PMID- 9938148 TI - Deep inelastic neutron scattering from single-crystal hcp 4He. PMID- 9938149 TI - Finite susceptibility of the Ising model on a hierarchical lattice. PMID- 9938150 TI - Phase-field methods for interfacial boundaries. PMID- 9938151 TI - Fixed points and domain growth for the Potts model. PMID- 9938152 TI - Mobility of positrons in polyethylene. PMID- 9938153 TI - New approach to enhanced heat exchange efficiencies at ultralow temperatures. PMID- 9938154 TI - Comments on Abraham's intrinsic interface structure. PMID- 9938156 TI - Nearest-neighbor exchange in solid 3He. PMID- 9938155 TI - Reply to "Comments on Abraham's intrinsic interface structure" PMID- 9938158 TI - Observation of muon-fluorine "hydrogen bonding" in ionic crystals. PMID- 9938157 TI - Comment on "Irrelevant variables, Landau expansions, and cubic anisotropy." PMID- 9938159 TI - ESR study of the temperature dependence of metallic complexes of alkali-metal doped polyacetylene. PMID- 9938161 TI - Neutron-diffraction evidence for ordering in the high-Tc phase of beta -di PMID- 9938160 TI - Pressure-induced superconductivity in high-pressure phases of Si. PMID- 9938162 TI - Effect of magnetic-field-induced frustration on the superconducting transition of proximity-coupled arrays. PMID- 9938163 TI - Surface term in the superconductive Ginzburg-Landau free energy: Application to thin films. PMID- 9938164 TI - Evidence for locally correlated spin canting in the reentrant spin-glass state of Au-Fe alloys. PMID- 9938166 TI - Finite-size scaling and the three-dimensional Ising model. PMID- 9938165 TI - Fractal dimensionality of percolation clusters in (FepNil-p)80P20. PMID- 9938167 TI - Macroscopic dynamics of randomly canted ferromagnets and skewed spin glasses. PMID- 9938168 TI - Elastic percolation models for cohesive mechanical failure in heterogeneous systems. PMID- 9938169 TI - Structural, electronic, and magnetic properties of Co: Evidence for magnetism stabilizing structure. PMID- 9938170 TI - Randomly ferromagnetic behavior of the mixed spinel system Cd Cr1.8In0.2S4. PMID- 9938171 TI - Monte Carlo study of a generalized-planar-model antiferromagnet with frustration. PMID- 9938172 TI - Fast heat-bath algorithm for the Ising model. PMID- 9938173 TI - Nonperturbative renormalization-group calculations for continuum spin systems. PMID- 9938175 TI - Photoemission spectroscopy for the spin-degenerate Anderson model. PMID- 9938174 TI - Velocity selection in dendritic growth. PMID- 9938176 TI - Evidence of a magnetic gaplike excitation in URu2Si2. PMID- 9938178 TI - Two-component model for the resistivity and noise of tunneling metal-insulator composites. PMID- 9938177 TI - Quantum Monte Carlo study of a lattice-atom model for excitonic fluids. PMID- 9938179 TI - Pressure dependence of the cyclotron mass of antimony. PMID- 9938180 TI - H-induced structural phase transitions on W(100) by surface infrared spectroscopy. PMID- 9938181 TI - Icosahedral aluminum-transition-metal alloys. PMID- 9938182 TI - Photoinduced luminescence from the noble metals and its enhancement on roughened surfaces. PMID- 9938183 TI - Numerical tests of high-precision multiple-scattering band theory. PMID- 9938185 TI - Plasma resonances in thin Bi films. PMID- 9938184 TI - Theoretical study of the cohesive and structural properties of Mo and W in bcc, fcc, and hcp structures. PMID- 9938186 TI - Optical absorption by clusters of small metallic spheres. PMID- 9938187 TI - Polarized-x-ray-absorption studies of graphite intercalated-bromine compounds. PMID- 9938188 TI - Embedded-atom-method functions for the fcc metals Cu, Ag, Au, Ni, Pd, Pt, and their alloys. PMID- 9938190 TI - Theory of inelastic electron tunneling intensities which includes a nonconstant barrier potential. PMID- 9938189 TI - Energy averaging and the flux-periodic phenomena in small normal-metal rings. PMID- 9938191 TI - Local-density total-energy supercell description of excited-state properties of solids: Ce photoemission and inverse photoemission spectra. PMID- 9938193 TI - Linearized atomic-cell orbital method for energy-band calculations. PMID- 9938192 TI - Generalized Langevin-equation approach to impurity diffusion in solids: Perturbation theory. PMID- 9938194 TI - Electronic heat capacity of the strongly exchange-enhanced metal USn3. PMID- 9938196 TI - Two-component lattice-gas model for surface segregation in liquid alloys. PMID- 9938195 TI - Comparative study of the formation of Cr/Ge and Ge/Cr thin-film interfaces. PMID- 9938197 TI - New approach to effective medium for composite materials: Application to electromagnetic properties. PMID- 9938198 TI - Determination of the electronic structure of transition-metal compounds: 2p x-ray photoemission spectroscopy of the nickel dihalides. PMID- 9938199 TI - Strong interference between decay channels and valence-electron rearrangements in core-hole spectroscopy. PMID- 9938200 TI - Elastic interactions between hydrogen atoms in metals. I. Lattice forces and displacements. PMID- 9938201 TI - Elastic interactions between hydrogen atoms in metals. II. Elastic interaction energies. PMID- 9938203 TI - Electronic structure of UPt3. PMID- 9938202 TI - Medium-energy ion-scattering analysis of the Cu(110) surface. PMID- 9938204 TI - Theoretical examination of the quantum-size effect in thin grey-tin films. PMID- 9938205 TI - Ordered hydrogen overlayers on metal surfaces. PMID- 9938206 TI - Experimental study of localization and electron-electron interaction effects in thin Au wires. PMID- 9938208 TI - Low-energy electron-loss spectroscopy of GaSe and InSe. PMID- 9938207 TI - Condensation transition in the one-dimensional extended Hubbard model. PMID- 9938209 TI - Large-amplitude quantum fluctuations and subgap optical absorption in trans polyacetylene. PMID- 9938210 TI - Analysis of photothermal ionization spectra of shallow impurities in silicon. PMID- 9938211 TI - Tight-binding Green's-function approach to off-center defects: Nitrogen and oxygen in silicon. PMID- 9938212 TI - High-resolution optical spectroscopy of nickel ions in II-VI semiconductors: Isotope shifts at the 3T1(F) 3T1(P) and 3T1(F) 3A2(F) Ni2+ transitions in CdS and ZnS crystals. PMID- 9938213 TI - Dependence of energy gap on x and T in Zn1-xMnxSe: The role of exchange interaction. PMID- 9938214 TI - Electron-electron interactions in GaAs-AlxGa1-xAs heterostructures. PMID- 9938216 TI - Semiempirical formalism for the calculation of deep-level wave functions in k space. PMID- 9938215 TI - Green's-function-quantum-defect treatment of impurity photoionization in semiconductors. PMID- 9938217 TI - Thermoelectric power of the two-dimensional electron gas in GaAs-AlxGa1-xAs heterostructures. PMID- 9938218 TI - Properties of shallow Li-related donors in GaP from optically detected magnetic resonance. PMID- 9938219 TI - General considerations on optical second-harmonic generation from surfaces and interfaces. PMID- 9938221 TI - Grating-coupler-induced intersubband resonances in electron inversion layers of silicon. PMID- 9938220 TI - Screened Coulombic impurity bound states in semi-infinite multiple-quantum-well systems. PMID- 9938222 TI - Energy-momentum relation for polarons confined to one dimension. PMID- 9938224 TI - Electronic structure of deep-lying sulfur centers in Si. PMID- 9938223 TI - Mobility of the two-dimensional electron gas at selectively doped n -type AlxGa1 xAs/GaAs heterojunctions with controlled electron concentrations. PMID- 9938225 TI - Solid-state analogue of the relativistic gases. PMID- 9938226 TI - Ultrasonic relaxation rates in palladium hydride and palladium deuteride. PMID- 9938228 TI - Hydrogenic energy levels in two dimensions at arbitrary magnetic fields. PMID- 9938227 TI - Quantitative analysis of streaks in reflection high-energy electron diffraction: GaAs and AlAs deposited on GaAs(001). PMID- 9938230 TI - k PMID- 9938229 TI - k PMID- 9938231 TI - Time decays of donor-bound excitons in GaAs under pressure-induced Gamma -X crossover. PMID- 9938232 TI - Phonon-induced shift in shallow donor levels of semiconductor quantum structures. PMID- 9938233 TI - Subbands and excitons in a quantum well in an electric field. PMID- 9938234 TI - Plasmons in semiconducting superlattices with a complex unit cell. PMID- 9938236 TI - Theory of the temperature dependence of Si(111)2 x 1 surface-state optical absorption. PMID- 9938235 TI - Raman scattering and optical-absorption studies of the metastable alloy system GaAsxSb1-x. PMID- 9938237 TI - Defect-enhanced annealing by carrier recombination in GaAs. PMID- 9938239 TI - Absorption effects in the determination of anomalous scattering factors using x ray refraction through a prism. PMID- 9938238 TI - High-pressure studies of GaAs-Ga1-xAlxAs quantum wells of widths 26 to 150 A PMID- 9938241 TI - First-principles determination of the sublinear dependence of the direct &) on hydrostatic pressure. PMID- 9938240 TI - Excess carrier densities in amorphous-silicon doping-modulated multilayers. PMID- 9938242 TI - New aspects of variable-range hopping in finite one-dimensional wires. PMID- 9938243 TI - Dissipative transport in transition regions between quantum Hall plateaus. PMID- 9938244 TI - Acoustic properties of heavily doped many-valley semiconductors in the weak localization regime. PMID- 9938245 TI - High-resolution spectroscopy of defect-bound excitons and acceptors in GaAs grown by molecular-beam epitaxy. PMID- 9938246 TI - Self-consistent electronic structures of polyacetylene. PMID- 9938248 TI - Drift and diffusion of paraexcitons in Cu2O: Deformation-potential scattering in the low-temperature regime. PMID- 9938247 TI - Coulomb effects in disordered solids. PMID- 9938249 TI - Strong electron-phonon coupling in defect luminescence in P-doped a-Si:H. PMID- 9938250 TI - Gallium-isotope fine structure of impurity modes due to defect complexes in GaAs. PMID- 9938251 TI - Nonresonant Faraday rotation in glassy semiconductors. PMID- 9938252 TI - Theory of conducting polymers with weak electron-electron interactions. PMID- 9938253 TI - Bound state of an external impurity at a semiconductor-semiconductor interface in the presence of a magnetic field. PMID- 9938254 TI - Electronic transport in molecular-beam-epitaxy-grown AlxGa1-xAs. PMID- 9938256 TI - Band-gap shifts in heavily doped n-type GaAs. PMID- 9938255 TI - Electron-hole liquid in layered InSe: Comparison of two- and three-dimensional excitonic states. PMID- 9938257 TI - Magnetophonon oscillations in quasi-two-dimensional quantum wells. PMID- 9938258 TI - Optical cross sections associated with deep-level impurities in semiconductors. PMID- 9938259 TI - Theoretical studies of metal disilicide-silicon interfaces. PMID- 9938260 TI - Phonon density of states, free energy, and anharmonicity of LiKSO4. PMID- 9938261 TI - High-pressure static and dynamic properties of the R3-barc phase of solid nitrogen. PMID- 9938262 TI - Polarized resonant Raman spectra of fully oriented trans-polyacetylene: Experiments and theory. PMID- 9938263 TI - Structural properties and electron density of NaCl. PMID- 9938264 TI - Dislocation dipoles in rare-gas monolayers. PMID- 9938265 TI - Electronic properties of glassy Pt-Si films. PMID- 9938266 TI - Time-resolved spectroscopy of the visible emission band in strontium titanate. PMID- 9938267 TI - Electro-optic contribution to Raman scattering from alkali halides. PMID- 9938268 TI - Scattering of high-energy phonons at irregular surfaces without and with liquid He. PMID- 9938269 TI - Polytypism: A controlled thermodynamic phenomenon. PMID- 9938270 TI - Potential-induced breathing model for the elastic moduli and high-pressure behavior of the cubic alkaline-earth oxides. PMID- 9938271 TI - Stability and instability in crystal growth. II. Asymmetric solutions of the thermodiffusion model. PMID- 9938272 TI - Electron energy bands and cohesive properties of CsCl, CsBr, and CsI. PMID- 9938273 TI - Initial growth of Ti on Si. PMID- 9938274 TI - Dynamical properties of copper halides. I. Interionic forces, charges, and phonon dispersion curves. PMID- 9938275 TI - Dynamical properties of copper halides. II. Theoretical study of the anomalies in the line shape of the transverse optic phonons. PMID- 9938276 TI - Calculation of anharmonic phonon couplings in C, Si, and Ge. PMID- 9938277 TI - Al-M+ centers (M=Li,Na,K) in a quartz crystal: Potential surfaces. PMID- 9938278 TI - Conductivity mode in blue bronze. PMID- 9938279 TI - Electronic structure of a GaAs quantum well in an electric field. PMID- 9938280 TI - Picosecond luminescence study of hot-carrier relaxation in 1.3- microm In0.72Ga0.28As0.6P0.4. PMID- 9938281 TI - Central-cell and screening effects on the binding energies of neutral chalcogen impurities in silicon. PMID- 9938282 TI - Isomerization-induced evolution of piezoreflectance structures in polyacetylene films. PMID- 9938283 TI - Effects of the e-e interaction on the localized modes of solitons in polyacetylene. PMID- 9938284 TI - Mechanism for spatial separation of charge carriers in inhomogeneous semiconductor alloys. PMID- 9938285 TI - FA centers in additively colored KI:Li crystals. PMID- 9938286 TI - Comment on "Thomas-Fermi-Dirac statistical theory of dispersive dielectric screening in undoped semiconductors at zero temperature." PMID- 9938287 TI - Comment on "Green's-function calculation of the lattice response near the vacancy in Si." PMID- 9938288 TI - Reply to "Comment on 'Green's-function calculation of the lattice response near the vacancy in Si'." PMID- 9938289 TI - Erratum: Application of a general self-cconsistenccy scheme in the linear combination of atomic orbitals formalism to the electronic and structural properties of Si and W PMID- 9938290 TI - Erratum: HgTe-CdTe superlattice subband dispersion PMID- 9938291 TI - Metal-insulator transition and the stability of rocksalt and zinc-blende crystal structures. PMID- 9938293 TI - Accurate and simple density functional for the electronic exchange energy: Generalized gradient approximation. PMID- 9938292 TI - Dimensional crossover of weak-localization and interaction effects in Nb0.53Ti0.47-Ge multilayers. PMID- 9938294 TI - Anomalous inelastic electron scattering from small metal particles. PMID- 9938295 TI - Henry's law of adsorption on a fractal surface. PMID- 9938296 TI - Direct observation of elastic strain and relaxation at a metal-metal interface by Auger electron diffraction: Cu/Ni(001). PMID- 9938298 TI - Observation of rotational anisotropy in the second-harmonic generation from a metal surface. PMID- 9938297 TI - Theoretical and experimental study of a surface state on Cr(110). PMID- 9938299 TI - Density-functional approximation for the correlation energy of the inhomogeneous electron gas. PMID- 9938300 TI - Diffusivities of Ni, Zr, Au, and Cu in amorphous Ni-Zr alloys. PMID- 9938301 TI - Impurity displacement by vacancy trapping in gold-implanted iron single crystals at low dose. PMID- 9938303 TI - Orientation of adsorbed CO on Pt(111)+K by x-ray photoelectron diffraction. PMID- 9938302 TI - Structure-induced electronic states for Hg overlayers on Ag(100). PMID- 9938304 TI - Quantum-interference contribution to the thermoelectric coefficient of degenerate and nondegenerate electron gases. PMID- 9938305 TI - Possibility for direct experimental determination of two-dimensional electron density of states. PMID- 9938306 TI - Interaction effects among two-dimensional electrons and holes. PMID- 9938308 TI - Photoemission study of the surface states that pin the Fermi level at Si(100)2 x 1 surfaces. PMID- 9938307 TI - Bolometric measurement of the charge-density-wave gap in TaS3. PMID- 9938309 TI - Zero-phonon line associated with the midgap level EL2 in GaAs: Correlation with the AsGa antisite defect. PMID- 9938311 TI - Two-dimensional hole-gas cyclotron line splitting in the extreme quantum regime. PMID- 9938310 TI - Light scattering determination of band offsets in GaAs-AlxGa1-xAs quantum wells. PMID- 9938312 TI - Evidence for germanium segregation on thin films of Ag on Ge(111). PMID- 9938313 TI - Ground-state variational wave function for the quasi-one-dimensional semiconductor quantum wire. PMID- 9938314 TI - Influence of doping on transport and recombination of excess charge carriers in a Si:H. PMID- 9938315 TI - Exactly exponential band tail in a glassy semiconductor. PMID- 9938316 TI - Microscopic calculation of the surface contribution to optical reflectivity: Application to Si. PMID- 9938318 TI - Influence of hydrostatic pressure on the platinum levels in silicon. PMID- 9938317 TI - Calculated superlattice and interface phonons of InAs/GaSb superlattices. PMID- 9938319 TI - Model supercell local-density calculations of the 3d excitation spectra in NiO. PMID- 9938321 TI - Interstitials in graphite and disordered carbons. PMID- 9938320 TI - Evidence for the absence of a c(2 x 2) superstructure for oxygen on Cu(100). PMID- 9938323 TI - Analysis of cermet films with large metal packing fractions. PMID- 9938322 TI - Statistical mechanics of the effective mass of the polaron. PMID- 9938324 TI - Scaling description of the dielectric function near the mobility edge. PMID- 9938325 TI - Comparison of transverse-electron-focusing and scanning-tunneling-microscopy measurements on Ag(001) and (011) surfaces. PMID- 9938326 TI - Layer-resolved shifts of photoemission and Auger spectra from physisorbed rare gas multilayers. PMID- 9938327 TI - Static properties of a uniform electron gas: A phenomenological approach. PMID- 9938328 TI - Efficient solution of Poisson's equation in linear combination of atomic orbitals calculations of crystal electronic structure. PMID- 9938329 TI - Rare-earth-metal-semiconductor interfacial reactions: Thermodynamic aspects. PMID- 9938330 TI - Photoemission from H adsorbed on Ni(111) and Pd(111) surfaces. PMID- 9938331 TI - Total-energy calculations for intermetallic compounds with a first-principles linear combination of atomic orbitals method. PMID- 9938332 TI - Electron momentum distribution in vanadium: Compton scattering measurements and band-structure calculation. PMID- 9938333 TI - Unoccupied surface states on Cu(001): A comparison of experiment and theory. PMID- 9938334 TI - Electronic densities of states of semi-infinite disordered chains: Comparisons of exact and analytic calculations. PMID- 9938335 TI - Deformation potentials and the electron-phonon interaction in metals. PMID- 9938336 TI - Anderson localization and delocalization in an electric field. PMID- 9938337 TI - Raman scattering and attenuated-total-reflection studies of surface-plasmon polaritons. PMID- 9938338 TI - Perturbation theory for the two-dimensional polaron in a magnetic field. PMID- 9938339 TI - High-pressure and low-temperature study of electrical resistance of lithium. PMID- 9938341 TI - Linear augmented-plane-wave calculation of the structural properties of bulk Cr, Mo, and W. PMID- 9938340 TI - Electronic structure of substoichiometric carbides and nitrides of titanium and vanadium. PMID- 9938343 TI - Dehancement of impurity and self-diffusion in niobium by tungsten additions. PMID- 9938342 TI - Practical method for full curved-wave theory analysis of experimental extended x ray-absorption fine structure. PMID- 9938344 TI - Theoretical examination of the trapping of ion-implanted hydrogen in metals. PMID- 9938346 TI - Interaction potential between rare-gas atoms and metal surfaces. PMID- 9938345 TI - Electronic structure of the Yb/Ge(111) interface. PMID- 9938347 TI - Optical and electrical properties of thin silver films grown under ion bombardment. PMID- 9938348 TI - Electronic-transport properties of amorphous Cu-Ti films. PMID- 9938349 TI - Calculation of elastic constants using isothermal molecular dynamics. PMID- 9938350 TI - Atomic structure of a {001} surface of Ni3Al. PMID- 9938352 TI - Highly accurate renormalized mode-coupling theory for the reflectivity of a diffraction grating. PMID- 9938351 TI - Experimental study of the three-dimensional ac conductivity and dielectric constant of a conductor-insulator composite near the percolation threshold. PMID- 9938353 TI - Core-electron binding energies of adsorbed metallic monolayers: Au/Ag(111). PMID- 9938354 TI - Metal-silicon interfaces and multiple scattering in their low-energy electron diffractions. PMID- 9938355 TI - Plasmon-pole and paramagnon-pole model of an electron liquid. PMID- 9938356 TI - High- and low-energy Auger-electron transitions in ytterbium and gold: Theory and experiments. PMID- 9938357 TI - Beyond the random-phase approximation in nonlocal-density-functional theory. PMID- 9938358 TI - Propagation of electromagnetic waves in displacively modulated crystals. PMID- 9938359 TI - Hopping conductivity in one dimension with asymmetric transfer rates. PMID- 9938361 TI - Random-phase-approximation study of the response function describing optical second-harmonic generation from a metal selvedge. PMID- 9938360 TI - Self-consistent calculation of electron-density profiles at strongly charged jellium surfaces. PMID- 9938362 TI - Electronic states in coupled random chains. PMID- 9938363 TI - Hybridization in correlated bands studied with the Gutzwiller method: Application to fluctuating valence and heavy fermions. PMID- 9938365 TI - Band structures of SixGe1-x alloys. PMID- 9938364 TI - Diffusion of an adsorbed particle: Dependence on the adatom-substrate interaction. PMID- 9938366 TI - Theory of the surface acoustic soliton. III. Effect of the anharmonic loss and surface inhomogeneities. PMID- 9938367 TI - Theory of cyclotron-resonance line shape for an electron-phonon system. PMID- 9938368 TI - Photon-drag experiment and the electromagnetic momentum in matter. PMID- 9938369 TI - Transient photovoltaic effect in semiconductor superlattices. PMID- 9938370 TI - Site symmetry and deformation-potential constants of Al-X acceptors in silicon. PMID- 9938371 TI - Transient photoinduced optical absorption spectroscopy in trigonal single-crystal selenium. PMID- 9938372 TI - Temperature dependence of the conductivity for the two-dimensional electron gas: Analytical results for low temperatures. PMID- 9938373 TI - Nonadiabatic phonon coupling for bound excitons in ZnTe. PMID- 9938375 TI - Hydrogen passivation of shallow-acceptor impurities in p-type GaAs. PMID- 9938374 TI - Temperature dependence of the optical spectra of Si, Ge, and Ge-Si alloys. PMID- 9938376 TI - Commutativity and transitivity of GaAs-AlAs-Ge(100) band offsets. PMID- 9938377 TI - Temperature dependence of the dielectric function and the interband critical points in orthorhombic GeS. PMID- 9938378 TI - Many-electron model of equilibrium metal-semiconductor contacts and semiconductor heterojunctions. PMID- 9938379 TI - Optical study of complex formation in Ag-doped CdTe. PMID- 9938381 TI - Raman scattering from the vibrational modes in Zn1-xMnxTe. PMID- 9938380 TI - Electrical study of Schottky barriers on atomically clean GaAs(110) surfaces. PMID- 9938382 TI - Plasmon-phonon-assisted electron-hole recombination in Si at very high carrier density. PMID- 9938383 TI - Electron charge densities at conduction-band edges of semiconductors. PMID- 9938384 TI - Many-body effects in the absorption, gain, and luminescence spectra of semiconductor quantum-well structures. PMID- 9938386 TI - Band tails in disordered systems. PMID- 9938385 TI - Experimental study of the current flow in the quantum Hall regime. PMID- 9938387 TI - Determination of the radius of convergence of the perturbation expansion using Pade approximants: Application to the Huckel limit of the Hubbard model for finite cyclic polyenes. PMID- 9938389 TI - Electric field dependence of the Hall effect in polar semiconductors: Streaming to accumulation transition. PMID- 9938388 TI - Synchrotron radiation study of Cd1-xMnxTe (0 <= x <= 0.65). PMID- 9938390 TI - Raman scattering from coupled plasmon-LO-phonon modes in n-type AlxGa1-xAs. PMID- 9938391 TI - Neutral (Cu-Li) complexes in GaP: The (Cu-Li)V bound exciton at 2.172 eV. PMID- 9938392 TI - Deep states associated with platinum in silicon: A photoluminescence study. PMID- 9938393 TI - Vibrational excitations in a-Ge:F,H alloys. PMID- 9938395 TI - Electronic properties of cubic crystals with an average of five valence electrons per atom. PMID- 9938394 TI - Instability mechanism in helicon-wave propagation in layered structures. PMID- 9938396 TI - Group-theoretical study of triple acceptors in group-IV semiconductors under uniaxial stress. PMID- 9938397 TI - Shubnikov-de Haas experiments on potassium-hydrogen graphite intercalation compounds (KHx-GIC's). PMID- 9938398 TI - Mechanical stress in a dielectric solid from a uniform electric field. PMID- 9938400 TI - Nonlinear coherent interaction and an instability of the polariton-biexciton system in CuCl. PMID- 9938399 TI - Electronic structure and stability of different crystal phases of magnesium oxide. PMID- 9938401 TI - Neutron diffraction study of potassium-graphite intercalation compounds at high pressure: Staging transitions and one-dimensional disorder. PMID- 9938403 TI - C 1s excitation studies of diamond (111). II. Unoccupied surface states. PMID- 9938402 TI - C 1s excitation studies of diamond (111). I. Surface core levels. PMID- 9938404 TI - Evidence of temperature-defect-induced first-order Raman scattering in pure NaCl crystals. PMID- 9938405 TI - Optical spectrum and Jahn-Teller splitting of Cu2+ sites in K2CuF4 based on ab initio studies of (CuF6)4- clusters. PMID- 9938406 TI - Nonlinear theory of domain walls and domain effective interactions in intercalation compounds. PMID- 9938408 TI - Brillouin spectroscopy of incommensurate Ba2NaNb5O15 at its 105-K phase transition. PMID- 9938407 TI - Laser spectroscopy of ion-size effects on point-defect equilibria in PbF2:Eu3+ PMID- 9938409 TI - X-ray intensity calculation in alkali-metal graphite intercalation compounds: Discommensuration-domain model. PMID- 9938410 TI - Bound magnetic polarons in diluted magnetic semiconductors: The high-temperature regime. PMID- 9938411 TI - Multilayer relaxation of a clean bcc Fe{111} surface. PMID- 9938413 TI - Plasmon bands in periodic conducting heterostructures. PMID- 9938412 TI - Temperature-dependent far-infrared absorption of a metal-insulator composite. PMID- 9938415 TI - Path-integral study of localization in the generalized polaron problem. PMID- 9938414 TI - Adsorption site of c(2 x 2) O on Ni(0001): An off-normal-direction energy dependent photoelectron-diffraction study. PMID- 9938416 TI - Three-body forces in the lattice dynamics of fcc nickel. PMID- 9938418 TI - Resonant carrier capture by semiconductor quantum wells. PMID- 9938417 TI - Phonon-emission rate in two-dimensional semiconductor microstructures. PMID- 9938419 TI - 3d photoemission study of the intermediate valence of Sm on Si(001). PMID- 9938420 TI - Correlation and competition between stimulated Raman and Brillouin scattering processes. PMID- 9938421 TI - Pseudopotential band structure of indium nitride. PMID- 9938422 TI - Anomalous ultrasonic attenuation in ammonium aluminum alum. PMID- 9938423 TI - Onset of oxidation of Al(111) at low temperatures: A study by electron-energy loss spectroscopy and Auger electron spectroscopy. PMID- 9938424 TI - Experimental observation of adsorbate orbital splitting at single-crystal metal surfaces. PMID- 9938425 TI - Hysteresis in the thermopower of 2H-TaSe2 in the charge-density-wave state. PMID- 9938426 TI - Comment on "Annihilation and creation of a Korteweg-de Vries soliton" PMID- 9938427 TI - Reply to "Comment on 'Annihilation and creation of a Korteweg-de Vries soliton' " PMID- 9938428 TI - Erratum: Computer simulation of local order in condensed phases of silicon PMID- 9938429 TI - New vacancy-related defects in n-type silicon. PMID- 9938430 TI - Noise spectra of three-dimensional random metal-insulator composites. PMID- 9938432 TI - Electronic-structure changes for " pi -bonded" CO chemisorbed on Cr(110). PMID- 9938431 TI - Observation of film states and surface-state precursors for Ag films on Si(111). PMID- 9938434 TI - Velocity dependence of binding energies and lifetimes of image states at surfaces. PMID- 9938433 TI - Surface Friedel oscillations and photoemission from simple metals. PMID- 9938435 TI - Electron-electron scattering in dirty three-dimensional aluminum films. PMID- 9938436 TI - Bulk and surface spin-orbit relaxation of the conduction electrons separated by weak-localization experiments. PMID- 9938437 TI - Analytic approach to the equation of Esbjerg and No-slashrskov. PMID- 9938438 TI - Constant-initial-state spectroscopy of black phosphorus: Reexamination of resonant photoemission. PMID- 9938439 TI - Localization and scaling in the quantum Hall regime. PMID- 9938440 TI - Pressure-induced first-order transition in layered crystalline semiconductor GeSe to a metallic phase. PMID- 9938441 TI - Nitrogen-carbon radiative defect at 0.746 eV in silicon. PMID- 9938443 TI - Localized phonons in stage-disordered graphite intercalation compounds. PMID- 9938442 TI - Absence of a Coulomb gap in a two-dimensional impurity band. PMID- 9938444 TI - Modeling a "tunneling" state in amorphous silicon dioxide. PMID- 9938445 TI - Vacancies in CsCl-type intermetallic compounds: Structural versus thermal. PMID- 9938446 TI - Bipolaron dynamics in nearly degenerate quasi-one-dimensional polymers. PMID- 9938447 TI - Observation of folded-zone acoustical phonons by Raman scattering in amorphous Si SiNx superlattices. PMID- 9938448 TI - Observation of the Nyquist phase-coherence time in thin Au-Pd wires. PMID- 9938449 TI - Observation of new set of anomalies in mass spectra of CsI cluster ions close to the ionization threshold. PMID- 9938450 TI - Raman study of phonons and intraband electronic excitations in antimony. PMID- 9938452 TI - Torsional-oscillation-induced spin-orbit coupling and ESR line broadening in tetramethyltetraselenafulvalenium salts PMID- 9938451 TI - Floating-gate technique applied to two-dimensional systems. PMID- 9938453 TI - Anisotropy of the electronic g factors for anomalous muonium in silicon and germanium. PMID- 9938454 TI - ESR studies of organic conductors with bis(ethylenedithio)tetrathiafulvalene (BEDT-TTF), (BEDT-TTF)2ClO4(C2H3Cl3)0.5, and (BEDT-TTF)3(ClO4)2, and their two dimensionality. PMID- 9938455 TI - Site-switched Tl0 atoms in Tl+-doped NaCl and KCl. PMID- 9938456 TI - Emission of thermal positrons from metal surfaces. PMID- 9938458 TI - Fermi superfluids at a rough surface. PMID- 9938457 TI - Possible existence of a Josephson effect in ferromagnets. PMID- 9938459 TI - Theory of superconductivity based on direct electron-phonon coupling. I. PMID- 9938460 TI - Theory of superconductivity based on direct electron-phonon coupling. II. PMID- 9938461 TI - Internal-magnetic-field distribution at the critical current of a type-II superconductor subjected to a parallel magnetic field. PMID- 9938462 TI - Structural, electronic, and magnetic properties of Au/Cr/Au(001) sandwiches: Theoretical total-energy studies. PMID- 9938463 TI - Electron tunneling into Nb3Sn, Nb3Ge, and Nb3Al. PMID- 9938465 TI - Plastic deformation, vacancy diffusion, and vacancy delocalization in bcc 3He. PMID- 9938464 TI - Inelastic polarized and unpolarized neutron scattering measurements on UBe13. PMID- 9938466 TI - Nonlinear wave propagation in periodic systems: The driven sine-Gordon chain. PMID- 9938468 TI - Real-space pairing in fermion systems. PMID- 9938467 TI - Superheating in He II and successive phase transitions in metastable states. PMID- 9938470 TI - Upper critical field and heat capacity in the reentrant superconducting system (Lu1-xErx)RuB2. PMID- 9938469 TI - Possible origin of the resistivity maximum in heavy-fermion systems. PMID- 9938471 TI - Polarized-neutron study of the paramagnetic scattering from CeCu2Si2. PMID- 9938472 TI - Evidence for an Anderson transition in granular Sn films. PMID- 9938473 TI - Magnetoconductance of thin-film superconductors near critical disorder. PMID- 9938474 TI - Theory for superconductivity in metallic multilayer compounds. PMID- 9938475 TI - Electronic structure of transition-metal impurities in copper. PMID- 9938477 TI - Soliton density in Rb2ZnBr4. PMID- 9938476 TI - Finite-size scaling study of the two-dimensional Blume-Capel model. PMID- 9938478 TI - Solitons in the one-dimensional Ising-like antiferromagnet CsCoBr3. PMID- 9938479 TI - Phase transitions in the Nb-D(H) system: Superlattice reflections near the alpha '- beta phase transition. PMID- 9938480 TI - Anisotropic Heisenberg interface between Ising bulk ferromagnets: A renormalization-group approach. PMID- 9938481 TI - Effects of substrate heterogeneity on adsorption isotherms near a two-dimensional gas-liquid critical point. PMID- 9938482 TI - Solitons in planar ferromagnets with biquadratic exchange. PMID- 9938483 TI - Surface ferromagnetism of Cr(001). PMID- 9938484 TI - Motion of damped sine-Gordon kinks in the presence of thermal fluctuations. PMID- 9938485 TI - Classification of continuous phase transitions and stable phases. I. Six dimensional order parameters. PMID- 9938486 TI - Effects of internal exchange fields on magnetization steps in diluted magnetic semiconductors. PMID- 9938488 TI - Linewidths in neutron scattering spectra of cerium Kondo compounds. PMID- 9938487 TI - Theory of the bound magnetic polaron in antiferromagnetic semiconductors. PMID- 9938489 TI - Interpolative solution for the periodic Anderson model of mixed-valence compounds. PMID- 9938490 TI - Slow equilibration in systems undergoing diffusion-controlled phase separation on a lattice. PMID- 9938491 TI - Phase diagrams for submonolayer films on weakly corrugated substrates. PMID- 9938492 TI - Valence fluctuations in ferromagnetic 4f systems. PMID- 9938493 TI - Gauge-symmetry breaking and phase transitions in strongly and weakly interacting Bose systems. PMID- 9938494 TI - Dielectric properties of dilute bcc antiferroelectric systems. PMID- 9938495 TI - Molecular-dynamics study of surface premelting effects. PMID- 9938496 TI - Evidence of a high-temperature dipole-glass phase in K2CrO4. PMID- 9938497 TI - Effect of hydrostatic pressure on the exchange interactions in a ferromagnetic spinel CdCr2Se4. PMID- 9938498 TI - Paramagnetic scattering from Fe(3.5 at. % Si): Neutron measurements up to the zone boundary. PMID- 9938499 TI - Finite-size study of the one-dimensional spin-(1/2) dimerized Heisenberg chain. PMID- 9938500 TI - Sine-Gordon kinks on a discrete lattice. I. Hamiltonian formalism. PMID- 9938501 TI - Sine-Gordon kinks on a discrete lattice. II. Static properties. PMID- 9938502 TI - Path-integral methods for treating quantal behavior in solids: Mean-field theory and the effects of fluctuations. PMID- 9938503 TI - Local magnetic field distributions. III. Disordered systems. PMID- 9938504 TI - Three-dimensional Anderson localization in nearly magnetic fermion systems. PMID- 9938505 TI - Crossover scaling in biased self-avoiding walks. PMID- 9938506 TI - Classical dynamics and quantum spectra for a nonintegrable three-spin system. PMID- 9938507 TI - Linear spin-wave theory of incommensurably modulated magnets. PMID- 9938508 TI - Analysis of extended series for bond percolation on the directed square lattice. PMID- 9938510 TI - Charge storage in spinless solitons in trans-(CH)x: In situ magnetic-resonance measurements during p-type electrochemical doping. PMID- 9938509 TI - Shear-induced superconductivity in beta -di PMID- 9938511 TI - Adequacy of lattice dynamics for high-temperature point-defect properties. PMID- 9938512 TI - Further study of the Kosterlitz-Thouless transition in 4He films. PMID- 9938513 TI - Josephson junction coupled to an open transmission line: An application to the theory of macroscopic quantum tunneling. PMID- 9938515 TI - Growth kinetics of the random-field Ising model cooled to zero temperature. PMID- 9938514 TI - Quasiparticle interaction in a nearly localized Fermi liquid: Application to 3He and heavy-fermion systems. PMID- 9938517 TI - Elastic moduli near percolation in a two-dimensional random network of rigid and nonrigid bonds. PMID- 9938516 TI - Mass renormalization of sine-Gordon systems on a finite support. PMID- 9938518 TI - Direct determination of the conductivity exponent in directed percolation. PMID- 9938519 TI - Erratum: Axial next-nearest-neighbor Ising (ANNNI) and extended-ANNNI models in external fields PMID- 9938520 TI - Disorder and spin correlations in an amorphous ferromagnet. PMID- 9938522 TI - Phonon peaks in magnetic neutron spectra. PMID- 9938521 TI - Crossover from relaxational to resonant tunneling dynamics for random-site interacting dipoles in (K1-xNax)TaO3. PMID- 9938524 TI - Vanishing coefficient in the nonanalytic free energy in superfluid 3He-A. PMID- 9938523 TI - Thermally detected EPR studies of Cr3+ ions in GaP. PMID- 9938525 TI - Dynamic nuclear polarization of liquid 3He in powered charcoal. PMID- 9938526 TI - Reentrant temperature dependence of the critical current in small tunnel junctions. PMID- 9938527 TI - Carrier-concentration dependence of critical superconducting current induced by the proximity effect in silicon. PMID- 9938528 TI - Specific heat of the ambient-pressure organic superconductor beta -di PMID- 9938529 TI - Competition between organic superconductivity and a displacive structural modulation in the molecular stacks in bis(ethylenedithio) tetrathiafulvalene perrhenate, (BEDT-TTF)2ReO4. PMID- 9938530 TI - Dimensional crossover and commensurability effect in V/Ag superconducting multilayers. PMID- 9938531 TI - Superlattice ordering in digenite, Cu2-xS. PMID- 9938533 TI - Frenkel-Kontorova model with anharmonic interactions. PMID- 9938532 TI - Critical correlation susceptibility relation in random-field systems. PMID- 9938534 TI - Spin-anisotropic electron-electron interactions in one-dimensional metals. PMID- 9938536 TI - Level repulsion and the dielectric relaxation in quadrupolar glasses. PMID- 9938535 TI - Resonant frequency dependence of spin relaxation in concentrated metallic spin glasses. PMID- 9938537 TI - Exponents for 1/f noise, near a continuum percolation threshold. PMID- 9938538 TI - Theory of phase-transition kinetics in systems with continuous symmetry. PMID- 9938539 TI - Local properties, long-range order, and quantum ferroelectricity in KTa1-xNgxO3. PMID- 9938540 TI - Local modes in dilute metal-hydrogen alloys. PMID- 9938541 TI - Anomalous electric and magnetic properties of V2O3 in the metallic state. PMID- 9938543 TI - Two- and three-dimensional Kronig-Penney model with delta -function-potential wells of zero binding energy. PMID- 9938542 TI - Gap in the spin excitations and magnetization curve of the one-dimensional attractive Hubbard model. PMID- 9938544 TI - Nonlocal pseudopotential calculation of lattice-dynamical properties of cesium metal. PMID- 9938545 TI - One-body models for transport properties of valence fluctuators: Exact results. PMID- 9938546 TI - Generation of nonequilibrium electron and lattice temperatures in copper by picosecond laser pulses. PMID- 9938547 TI - Mean-square atomic displacement of alkali-metal atoms: A comparison of the lattice-dynamics and molecular-dynamics results. PMID- 9938548 TI - Average square atomic displacement: A comparison of the lattice-dynamics, molecular-dynamics, and Monte Carlo results. PMID- 9938549 TI - Complex dielectric response of metal-particle clusters. PMID- 9938550 TI - Calculations of the driving force of electromigration in hcp metals: Zn, Cd, Mg. PMID- 9938551 TI - Frequency-dependent hopping conductivity in a static electric field in a random one-dimensional lattice. PMID- 9938552 TI - Electronic and vibrational spectra of two-dimensional quasicrystals. PMID- 9938553 TI - Photoemission study of the development of the Ti/GaAs(110) interface. PMID- 9938554 TI - Small-atom approximation in forward- and back-scattering photoelectron spectroscopies. PMID- 9938555 TI - Spherical-wave effects in photoelectron diffraction. PMID- 9938556 TI - Soliton-breather approach to classical sine-Gordon thermodynamics. PMID- 9938558 TI - Final-state effects in x-ray photoemission spectra. PMID- 9938557 TI - Monte Carlo evaluation of trial wave functions for the fractional quantized Hall effect: Disk geometry. PMID- 9938559 TI - Spectroscopy of image-potential states with inverse photoemission. PMID- 9938560 TI - Chemisorption on disordered binary alloys. PMID- 9938561 TI - Two-dimensional valence-electronic structure of a monolayer of Ag on Cu(001). PMID- 9938562 TI - Surface states in the epitaxial growth of titanium on copper (111). PMID- 9938563 TI - Quenching and electron-irradiation effects in ordered beta -PdH(D)0.63 around the resistivity anomaly near 50 K. PMID- 9938564 TI - e-e scattering in the presence of strong magnetic fields: Effect of the Landau quantization. PMID- 9938565 TI - Enhanced intersubband absorption due to impurity particles inside the insulator region of a metal-insulator-semiconductor system. PMID- 9938566 TI - Soliton dynamics of nonlinear diatomic lattices. PMID- 9938568 TI - Self-energy of a moving charge in the presence of a metal surface. PMID- 9938567 TI - Alkali-metal-induced changes in the multielectron excitations of CO/Cu(100). PMID- 9938569 TI - Volumetric and structural contributions to the interatomic potentials and elastic moduli of cubic metals. PMID- 9938570 TI - Microscopic model for propagation of shock-induced detonations in energetic solids. PMID- 9938571 TI - Angle-resolved uv photoemission of Ce(001). PMID- 9938572 TI - Electronic density of states and the x-ray photoelectron spectra of the valence band of Cu-Pd alloys. PMID- 9938573 TI - Elastic behavior and vibrational anharmonicity of a bulk Pd40Ni40P20 metallic glass. PMID- 9938574 TI - Low-amplitude breather and envelope solitons in quasi-one-dimensional physical models. PMID- 9938575 TI - Convergent scheme for light scattering from an arbitrary deep metallic grating. PMID- 9938576 TI - Theory of the exciton molecule bound to an isoelectronic impurity in GaP. PMID- 9938577 TI - Electronic structure of the high-pressure modifications of CuCl, CuBr, and CuI. PMID- 9938579 TI - Bonding in semiconducting Ag6-cluster compounds: PMID- 9938578 TI - Thermoreflectance studies of transition-metal dichalcogenides between 1 and 9 eV. PMID- 9938580 TI - Valence-band electronic structure of silicon nitride studied with the use of soft x-ray emission. PMID- 9938581 TI - Low-frequency dielectric response of the charge-density wave in (TaSe4)2I. PMID- 9938582 TI - Low-frequency response of pinned charge-density-wave condensates. PMID- 9938583 TI - Application of a general self-consistency scheme in the linear combination of atomic orbitals formalism to the electronic and structural properties of Si and W. PMID- 9938584 TI - Statistics for electrons, solitons, and polarons in trans-polyacetylene and consequences for conductivity. PMID- 9938585 TI - Lattice dynamics of layered-structure compounds: PdTe2. PMID- 9938586 TI - Magneto-roton theory of collective excitations in the fractional quantum Hall effect. PMID- 9938587 TI - Localization and screening anomalies in two-dimensional systems. PMID- 9938588 TI - Dynamics of the creation of light-induced defects in amorphous silicon alloys. PMID- 9938589 TI - NMR Study of Si:As and Si:P near the metal-insulator transition. PMID- 9938590 TI - Optical absorption of a soliton lattice and applications to trans-polyacetylene. PMID- 9938591 TI - Binding energy of the electron-hole liquid in quantum wells. PMID- 9938592 TI - Electroreflectance study of the Burstein-Moss shift in indium phosphide. PMID- 9938594 TI - Electronic structure of Sb overlayers on GaAs(110). PMID- 9938593 TI - Nonlocal exchange and correlation in surface calculations: An application to GaAs(110). PMID- 9938596 TI - Charge transfer, polarization, and relaxation effects on the Auger line shapes of Si. PMID- 9938595 TI - Temperature dependence of the Si and Ge (111)2 x 1 surface-state optical absorption. PMID- 9938597 TI - Differences in optical properties of (111) and (100) CdTe/(Cd,Mn)Te superlattices. PMID- 9938598 TI - HgTe-CdTe superlattice subband dispersion. PMID- 9938599 TI - Exciton trapping in molecular crystals by phonon emission at impurity sites. PMID- 9938601 TI - Interruption of conjugations of polyacetylene chains. PMID- 9938600 TI - Inverse-photoemission study of unoccupied electronic states in Ge and Si: Bulk energy bands. PMID- 9938602 TI - Lithium insertion in the two crystallographic forms of the binary-phase Mo15Se19. PMID- 9938603 TI - Low-temperature diffusion and solubility of Ni in P-doped Czochralski-grown Si. PMID- 9938604 TI - High-frequency conductivity of type-II superlattices. PMID- 9938605 TI - Theory of the multicenter bond. PMID- 9938606 TI - Transparent conducting PbO2 films prepared by activated reactive evaporation. PMID- 9938608 TI - Divacancy binding enthalpy and contribution of divacancies to self-diffusion in Si. PMID- 9938607 TI - Quasiparticle spectrum and thermodynamics of phi solitons (discommensurations) in the charge-density-wave state. PMID- 9938609 TI - Local symmetry of nitrogen pairs in GaP. PMID- 9938611 TI - Fracton contribution to the temperature dependence of the homogeneous linewidth of the 5D0-7F0 transition in Eu3+-doped glasses. PMID- 9938610 TI - Model calculation of nitrogen properties in III-IV compounds. PMID- 9938613 TI - d-d transfer in transition-metal monoxides and dihalides. PMID- 9938612 TI - Pseudosurface wave structures in phonon imaging. PMID- 9938614 TI - Electron-beam-induced damage and structure of SbCl5-graphite intercalation compounds. PMID- 9938615 TI - Frequency shifts of vibrational and rotational states of dilute H2, D2, and HD impurities in solid Ar under pressure. PMID- 9938616 TI - Quasielastic light scattering in oxygen-ion conductors. PMID- 9938618 TI - Theory of nonlinear resonant absorption in dielectric glasses at low temperatures. PMID- 9938617 TI - Pseudopotential theoretical study of the alkali metals under arbitrary pressure: Density, bulk modulus, and shear moduli. PMID- 9938619 TI - Donor dependence of polarizability and electron wave-function volume for shallow states in semiconductors. PMID- 9938621 TI - Quantum contribution to Henry's law of adsorption. PMID- 9938620 TI - Weak-localization and Coulombic interaction effects in the low-temperature resistivity and magnetoresistivity of Y-Al metallic glasses. PMID- 9938623 TI - Anisotropy of Dingle temperatures in magnesium. PMID- 9938622 TI - Orthogonality catastrophe and the x-ray photoemission spectrum: Critical amplitude at finite temperatures. PMID- 9938624 TI - van der Waals interaction between a tungsten surface and iridium and tantalum atoms. PMID- 9938625 TI - "Superlattices" in quenched Al-Si-Mn quasicrystals. PMID- 9938626 TI - Quantum effects in the trajectories of sputtered ions. PMID- 9938628 TI - 1/f noise in a d-dimensional hopping model with static disorder. PMID- 9938627 TI - Convergence properties as a function of spatial dimensionality of gradient expansions for the ground-state energy of an inhomogeneous electron gas. PMID- 9938629 TI - Blue shift of the dipolar plasma resonance in small silver particles on an alumina surface. PMID- 9938631 TI - Interpretation of the "sagittal resonance" in the surface vibrational spectrum of some alkali halides. PMID- 9938630 TI - Ground-state properties of polytypes of silicon carbide. PMID- 9938632 TI - Activation volumes in lead halides and other solids. PMID- 9938633 TI - Jahn-Teller effect in the electronic Raman scattering of Co2+ in MgO. PMID- 9938634 TI - Comments on "Electronic structure of hydrogenated and unhydrogenated amorphous SiNx (0 <= x <= 1.6): A photoemission study" PMID- 9938636 TI - Statistical estimation of the number of minima in a function with a finite number of variables. PMID- 9938635 TI - Reply to "Comments on 'Electronic structure of hydrogentated and unhydrogentated amorphous SiNx (0 <= x <= 1.6): A photoemission study' " PMID- 9938638 TI - Thermal fluctuations of the order parameter in charge-density waves. PMID- 9938637 TI - Erratum: Empty electronic states at the (100), (110), and (111) surfaces of nickel, copper, and silver PMID- 9938639 TI - Phonon-fracton crossover and scaling of the sound velocity. PMID- 9938641 TI - Theoretical study of the surface energy and surface relaxation of the W(001) surface. PMID- 9938640 TI - Vibrational analysis of water adsorbed on Pd(100): Sensitivity of the isotope shifts of bending modes to the bonding site. PMID- 9938642 TI - Subsurface core-level shifts for an Au monolayer buried in Ag(111). PMID- 9938643 TI - Electronic-structure and magnetic-moment calculation for Y2Fe14B. PMID- 9938644 TI - Transport properties of substitutionally disordered alloys. PMID- 9938645 TI - Formation of icosahedral Al-Mn by ion implantation into oriented crystalline films. PMID- 9938646 TI - Geometric structure and surface vibrational resonances: The bcc Fe(111) surface. PMID- 9938647 TI - Shapiro-step spectrum and phase-velocity coherence in NbSe3 in a uniform temperature gradient. PMID- 9938648 TI - Raman scattering from (AlAs)m(GaAs)n ultrathin-layer superlattices. PMID- 9938649 TI - Identification of the arsenic vacancy defect in electron-irradiated GaAs. PMID- 9938650 TI - Resonant magnetotunneling in GaAlAs-GaAs-GaAlAs heterostructures. PMID- 9938651 TI - Raman scattering study of acoustical zone-center gaps in GaAs/AlAs superlattices. PMID- 9938652 TI - Structural reactions of Si{111} with cobalt and formation of cobalt disilicide. PMID- 9938653 TI - Excitation gap in the fractional quantum Hall effect: Finite layer thickness corrections. PMID- 9938654 TI - Absence of coherence effects of carrier energy and velocity in GaAs+-AlGaAs-GaAs- tunnel structures. PMID- 9938656 TI - Plasma resonance in the high-frequency conductivity of a superlattice. PMID- 9938655 TI - Magnetoconductance of pinched silicon accumulation layers. PMID- 9938657 TI - Conductance anomaly in a GaAs/Ga0.77Al0.23As heterojunction. PMID- 9938658 TI - Raman spectra of shallow acceptors in quantum-well structures. PMID- 9938659 TI - Magnetic polaron effects for excitons in narrow CdTe-(Cd,Mn)Te quantum wells. PMID- 9938660 TI - Substrate-dependent valency of Yb chemisorbed onto Si(111)7 x 7, Si(100)2 x 1, and a-Si surfaces. PMID- 9938661 TI - Observation of a pulse-duration memory effect in K0.30MoO3. PMID- 9938662 TI - Thermally induced abrupt collapse of a shallow donor state in a ferromagnetic semiconductor. PMID- 9938663 TI - Fractional statistics and the quantum Hall effect of two-dimensional fermion and boson systems. PMID- 9938664 TI - Thermoelectric properties of a two-dimensional electron gas exhibiting the quantum Hall effect. PMID- 9938666 TI - Theoretical predictions for the surface states on Ge(111)2 x 1: The degree of antibonding surface-state filling and relative shifts of the two surface-state bands as functions of doping level. PMID- 9938665 TI - Direct observation of three-branch polariton dispersion in the A exciton of CdS by resonant Brillouin scattering. PMID- 9938667 TI - Band-structure determination of GaAs from hot-electron luminescence. PMID- 9938668 TI - Optically detected magnetic resonance of nonradiative recombination via the AsGa antisite in p-type GaAs. PMID- 9938669 TI - Prediction of a low-spin ground state in the GaAs:V2+ impurity system. PMID- 9938671 TI - New insight into the electronic structure of a As2Se3. PMID- 9938670 TI - Microwave Hall conductivity of the two-dimensional electron gas in GaAs-AlxGa1 xAs. PMID- 9938673 TI - Scaling dielectric data on Rb1-x(NH4)xH2PO4 structural glasses and their deuterated isomorphs. PMID- 9938672 TI - Evidence for a wide continuum of polymorphs in a-SiO2. PMID- 9938674 TI - Multielectron configurations in the x-ray-absorption near-edge structure of NiO at the oxygen K threshold. PMID- 9938675 TI - Kinetic many-body model of recrystallization of pure and doped amorphous silicon. PMID- 9938676 TI - New analysis of lone-pair binding-energy shifts in photoemission from adsorbed molecules: CO and NH3 on Cu(100). PMID- 9938677 TI - Formation and decomposition of GexSil-x(100)(2 x 1):H and GexSil-x(100)(1 x ):2H. PMID- 9938679 TI - Paramagnetic neutron scattering from the Heisenberg ferromagnet EuO. PMID- 9938678 TI - Hyperfine studies of dangling bonds in amorphous silicon. PMID- 9938680 TI - Role of quantum coherence in series resistors. PMID- 9938681 TI - Electron transmission in the energy gap of thin films of argon, nitrogen, and n hexane. PMID- 9938682 TI - Measurement and calculation of the pressure dependence of the Mossbauer isomer shift of metallic 119Sn for the pressure range 0 <= P <= 310 kbar. PMID- 9938684 TI - Dynamical features of a hydrogen-lithium complex in MgO:Li studied by EPR. PMID- 9938683 TI - Positron motion in metals. III. Effects of positron interactions with electrons and phonons. PMID- 9938685 TI - Vacancy and labeled-particle hopping with interactions. PMID- 9938687 TI - Iron-ion-implantation effects in forsterite (Mg2SiO4) and annealing behavior. PMID- 9938686 TI - Double-quantum nutations in a two-level spin system. PMID- 9938688 TI - Calculation of the spin-orbit-coupling parameter of deep impurities in semiconductors in the complete neglect of differential overlap approximation. PMID- 9938689 TI - Perpendicular upper critical field of thick proximity-coupled multilayers. PMID- 9938690 TI - Localization and resonant transmission of third-sound waves on a random substrate. PMID- 9938691 TI - Evidence for large-scale structures in granular superconductors. PMID- 9938692 TI - Josephson-junction ladders and quantum fluctuations. PMID- 9938694 TI - Elastic and plastic behavior of a fluxoid lattice in the saturation region of the global pinning force in superconducting Nb-Ta. PMID- 9938693 TI - Superconductivity, crystal-field effects, and magnetic order in the (Sm1 xYx)Rh4B4 mixed ternary system. PMID- 9938696 TI - Anderson localization and the theory of dirty superconductors. II. PMID- 9938695 TI - Quantum size effects in superfluid 3He films. PMID- 9938697 TI - Optimal three-body correlations and elementary diagrams in liquid 4He. PMID- 9938699 TI - Peak and history effects in two-dimensional collective flux pinning. PMID- 9938700 TI - Effect of a convex boundary on a rarefied classical or quantum gas: Flow past a stationary boundary and the effect of an oscillating boundary on the gas. PMID- 9938698 TI - Normal-state and superconducting properties of the heavy-fermion compound UBe13 in magnetic fields. PMID- 9938701 TI - Yang-Lee edge for the two-dimensional Ising model. PMID- 9938702 TI - Derivation of exact results for the single-ion Kondo problem with the use of diagrammatic methods. PMID- 9938703 TI - Magnetic properties of FexCu100-x solid solutions. PMID- 9938705 TI - Critical behavior of disordered degenerate semiconductors. I. Models, symmetries, and formalism. PMID- 9938704 TI - Theory of bulk and surface magnons in Heisenberg ferromagnetic superlattices. PMID- 9938706 TI - Critical behavior of disordered degenerate semiconductors. II. Spectrum and transport properties in mean-field theory. PMID- 9938707 TI - Equation of state of solid 4He. PMID- 9938709 TI - n-vector model in the limit n-->0 and the statistics of linear polymer systems: A Ginzburg-Landau theory. PMID- 9938708 TI - Effective-medium theory of percolation on central-force elastic networks. III. The superelastic problem. PMID- 9938710 TI - Defect-mediated melting and new phases in three-dimensional systems with a single soft direction. PMID- 9938711 TI - Landau theory of wetting in systems with a two-component order parameter. PMID- 9938712 TI - Magnetic properties of superlattices formed from ferromagnetic and antiferromagnetic materials. PMID- 9938713 TI - Low-temperature structures of Xe on graphite in the one- to two-layer regime. PMID- 9938714 TI - Interfacial tension and correlation lengths for the three-state Potts model in two dimensions. PMID- 9938715 TI - Crossover from contact propagation to chemical propagation in first-passage percolation. PMID- 9938717 TI - Intrinsic anharmonicities in the BX4 2- orthorhombic sublattice. PMID- 9938716 TI - Effective properties of two-phase disordered composite Media. I. Simplification of bounds on the conductivity and bulk modulus of dispersions of impenetrable spheres. PMID- 9938719 TI - Phonons, electronic transitions, and magnetic susceptibility in CeyS4. PMID- 9938718 TI - Model for the hybridization effect in disordered systems. PMID- 9938720 TI - Transport properties and localized spin fluctuations in PtNi alloys. PMID- 9938721 TI - Reentrant melting on an imperfect surface. PMID- 9938722 TI - Magnetic susceptibility of semimagnetic semiconductors: The high-temperature regime and the role of superexchange. PMID- 9938723 TI - Vortices and strings: Phase transition in anisotropic planar-rotor systems. PMID- 9938724 TI - Non-Gaussian models for critical fluctuations. PMID- 9938725 TI - Magnetic excitations in EuxSr1-xS in high magnetic fields. PMID- 9938727 TI - Monte Carlo study of the domain kinetics of the Ising model with random coupling constants. PMID- 9938726 TI - Solid and liquid carbon monoxide studied with the use of constant-pressure molecular dynamics. PMID- 9938728 TI - Two-dimensional spin-flop transition in CoCl2-graphite intercalation compounds. PMID- 9938729 TI - Static and dynamic critical behavior of extended-defect N-component systems in cubic anisotropic crystals. PMID- 9938730 TI - Fluctuation-induced first-order phase transition of extended-defect N-component systems in cubic anisotropic crystals. PMID- 9938731 TI - Internal-field distribution in spin-glasses with dipolar interactions. PMID- 9938732 TI - Very peculiar properties of kinks in a driven damped anisotropic spin chain. PMID- 9938733 TI - Influence of point defects on the lattice-site occupation of nonsoluble atoms implanted in vanadium. PMID- 9938734 TI - High-intensity transition in the low-energy part of the electron-energy-loss spectra of Yb and related metals. PMID- 9938735 TI - Reinterpretation of oxygen on Al samples by variable-energy positrons. PMID- 9938736 TI - Penetration depth of V3Si. PMID- 9938737 TI - Generalized nonlinear Langevin equation for a rotor. PMID- 9938738 TI - Magnetic susceptibility and low-lying crystal-field energies for CaF2:Ce3+ PMID- 9938740 TI - Three-dimensional percolation with removed lines of sites. PMID- 9938739 TI - Comparative study of the discrete and the continuous Hubbard-Stratonovich transformation for a one-dimensional spinless fermion model. PMID- 9938742 TI - Effects of trilinear symmetry breaking on the Potts-model transition of uniaxially stressed SrTiO3. PMID- 9938741 TI - Magnetic properties of dipolar crystals with rhombohedral symmetry. PMID- 9938743 TI - Uniaxial-biaxial phase transition in lyotropic nematic solutions: Local biaxiality in the uniaxial phase. PMID- 9938744 TI - Hopping diffusion across interfaces. PMID- 9938745 TI - Dzyaloshinsky-Moriya anisotropy in reentrant alloys. PMID- 9938747 TI - Comments on the antiferromagnetic ordering of TbCo2Si2 and DyCo2Ge2. PMID- 9938746 TI - Observation of the volume discontinuity in the insulator-to-metal transition in CsI in x-ray diffraction experiments. PMID- 9938749 TI - Erratum: Slow orientational-motional correlation-time measurements for anisotropic NMR centers in polycrystalline-amorphous condensed matter PMID- 9938748 TI - Erratum: Polaronic behavior of electrons on a liquid-helium film PMID- 9938750 TI - Destruction of superconductivity in quench-condensed two-dimensional films. PMID- 9938751 TI - Unexpected observation in measurements of transport coefficients in 3He-4He mixtures near T lambda. PMID- 9938752 TI - Phenomenological trends for heavy Fermi liquids and narrow-band metals. PMID- 9938753 TI - Effect of 4He on the magnetic susceptibility of 3He adsorbed on sintered silver powder. PMID- 9938754 TI - Interaction of superconductivity and itinerant-electron magnetism: Critical fields of Ni/V superlattices. PMID- 9938755 TI - Optical diffraction on fractals. PMID- 9938756 TI - Critical behavior of Mott variable-range hopping in Si:As near the metal insulator transition. PMID- 9938757 TI - Magnetotransport near the metal-insulator transition in Cd0.6Mn0.4Se. PMID- 9938758 TI - Magnetic properties of Al-Si-Mn and Al-Mn quasicrystals and amorphous films. PMID- 9938759 TI - Dynamics of the two-dimensional axial third-nearest-neighbor Ising model: Entrainment and diffusivity. PMID- 9938761 TI - Ordering and relaxation in spin glasses. PMID- 9938760 TI - Isothermal reversal of the remanent magnetization in Cu75Mn25. PMID- 9938762 TI - Dynamic scaling and the field-dependent critical line in a fractal cluster model of spin glasses. PMID- 9938763 TI - Nuclear-spin relaxation near the metal-insulator transition. PMID- 9938764 TI - Magnetic excitations on two-dimensional percolating clusters. PMID- 9938765 TI - Magnon-fracton crossover of the spin-wave density of states in the diluted two dimensional ferromagnet. PMID- 9938766 TI - Method of determining parameters of lattice models. PMID- 9938767 TI - Critical behavior of the transverse susceptibility in a CuMn spin glass. PMID- 9938769 TI - Excluded-volume explanation of Archie's law. PMID- 9938768 TI - Magnetic structure of the heavy-fermion compound U2Zn17. PMID- 9938770 TI - Quantization of the Hall conductance from density quantization alone. PMID- 9938771 TI - Autoionization in bulk, multilayer, and monolayer Cr. PMID- 9938772 TI - Angle-resolved photoemission study of the surface and bulk electronic structure of Mg(0001) and Mg(112-bar0). PMID- 9938773 TI - Structure and growth of crystalline superlattices: From monolayer to superlattice. PMID- 9938774 TI - Numerical comparison between the "channel model" and the "effective-electron model" descriptions of linear superexchange interactions in ionic solids. PMID- 9938775 TI - X-ray crystallographic studies of Pb monolayers on Cu(110) surfaces. PMID- 9938776 TI - Anomalously low PMID- 9938777 TI - Hydrodynamic-model calculation of second-harmonic generation at a metal surface. PMID- 9938778 TI - Surface acoustic waves in Ni/V superlattices. PMID- 9938779 TI - Comparative study of model potentials for the calculation of dielectric properties of small metal particles. PMID- 9938780 TI - Linearized augmented-plane-wave study of chemisorption of sulfur on Fe(001). PMID- 9938781 TI - Edge magnetoplasmons in a two-dimensional electron fluid confined to a half plane. PMID- 9938782 TI - Pairwise-additive models for atom-surface interaction potentials: An ab initio study of He-LiF. PMID- 9938783 TI - Thermoelectric power of Fe-Zr and Co-Zr metallic glasses. PMID- 9938784 TI - Unoccupied bulk, surface, and image states on Ni(001), Ni(111), and Ni(110). PMID- 9938785 TI - Observation of a size effect in laser-induced thermomagnetic potentials in bismuth thin films. PMID- 9938787 TI - Theory of second-harmonic generation by small metal spheres. PMID- 9938786 TI - Conduction-electron g-factor measurements in platinum. PMID- 9938788 TI - Theory of the perpendicular-field cyclotron-resonance anomaly in potassium. PMID- 9938789 TI - Channeling measurement of irradiation-induced lattice-site change of oxygen atoms in niobium at 10 and 293 K. PMID- 9938790 TI - Total-energy calculations of the structural properties of the group-V element arsenic. PMID- 9938792 TI - Percolation effects in the optical properties of Ni-MgO composites. PMID- 9938791 TI - Coupling of source and drain to a quantum Hall system. PMID- 9938793 TI - Itinerant antiferromagnetism in the nearly-heavy-fermion compound NpSn3. PMID- 9938794 TI - Magnetoplasma modes of the two-dimensional electron gas at nonintegral filling factors. PMID- 9938795 TI - Compositional dependence of the Raman frequencies and line shapes of Cd1-xZnxTe determined with films grown by molecular-beam epitaxy. PMID- 9938796 TI - Electronic structure of a self-interaction-corrected lithium cluster. PMID- 9938797 TI - Crystal truncation rods and surface roughness. PMID- 9938799 TI - Impurity effect, degeneracy, and topological invariant in the quantum Hall effect. PMID- 9938798 TI - Transport properties of an incommensurate system. PMID- 9938800 TI - Anomalous lattice dynamics of fcc lanthanum. PMID- 9938802 TI - Exchange and correlation energies in density-functional theory: Bounds from available data. PMID- 9938801 TI - Impact-collision ion-scattering spectroscopy of Cu(110) and Cu(110)-(2 x 1)-O using 5-keV 6Li+ PMID- 9938803 TI - Light scattering from a dipole near a rough metallic surface. PMID- 9938804 TI - Ground-state properties of dilute magnetic alloys. PMID- 9938805 TI - Thermodynamic Green's-function theory of quantum magnetic field effects in the dynamic, nonlocal longitudinal dielectric-response properties of a bounded solid state plasma. PMID- 9938806 TI - Zener tunneling in quantum sine-Gordon systems. PMID- 9938807 TI - Ground-state energy of a polaron in n dimensions. PMID- 9938808 TI - Relaxation and nonradiative decay in disordered systems. II. Two-fracton inelastic scattering. PMID- 9938809 TI - Fully relativistic energy bands and cohesive energy of ReSi2. PMID- 9938810 TI - Carrier transport through grain boundaries in semiconductors. PMID- 9938811 TI - Screening effect on the Landau-level broadening for electrons in GaAs-Ga1-xAlxAs heterojunctions. PMID- 9938812 TI - Self-trapping in quasi-one-dimensional solids. PMID- 9938813 TI - Generalized Kohn-Sham theory for electronic excitations in realistic systems. PMID- 9938814 TI - Quantum Hall effect in In0.53Ga0.47As-InP heterojunctions with two populated electric subbands. PMID- 9938815 TI - Theory of deep electronic levels of large chalcogen (S, Se, and Te) complexes in Si. PMID- 9938816 TI - Effect of nonparabolicity on the binding energy of a hydrogenic donor in a quantum well with a magnetic field. PMID- 9938817 TI - Reexamination of the structure of a laser-stabilized Si{111}1 x 1 surface. PMID- 9938819 TI - Disorder and the fractional quantum Hall effect: Activation energies and the collapse of the gap. PMID- 9938818 TI - Collective excitations of fractional Hall states and Wigner crystallization in higher Landau levels. PMID- 9938820 TI - Hall conductivity and Lorentz force law for two-band semiconductors. PMID- 9938821 TI - Decay kinetics of persistent photoconductivity in semiconductors. PMID- 9938822 TI - Polarization-dependent C(K) near-edge x-ray-absorption fine structure of graphite. PMID- 9938823 TI - Nonlinear Landau absorption in III-V semiconductors near the fundamental absorption edge. PMID- 9938824 TI - Dependence of the direct and indirect gap of AlSb on hydrostatic pressure. PMID- 9938825 TI - Theory of impurity-doping effect on electronic states in a quasi-two-dimensional structure semiconductor. PMID- 9938827 TI - Absorption edge of Zn1-xMnxTe under hydrostatic pressure. PMID- 9938826 TI - Vibrational properties of the Si(100)2 x 1 surface. PMID- 9938828 TI - MeV ion damage in GaAs single crystals: Strain saturation and role of nuclear and electronic collisions in defect production. PMID- 9938829 TI - Bound polaron in GaAs-GaAlAs quantum-well structures. PMID- 9938830 TI - Structural models of the amorphous alloy Ge0.20As0.40Se0.40 by a random technique. PMID- 9938831 TI - Recombination and impact-ionization peculiarities in many-valley semiconductors. PMID- 9938832 TI - Surface structure of epitaxial CoSi2 crystals grown on Si(111). PMID- 9938833 TI - Anisotropy of the fundamental absorption edge of TlSbS2. PMID- 9938834 TI - Quantum-limit laser-cyclotron pumping of spin waves in the europium chalcogenides assisted by Landau electrons. PMID- 9938835 TI - Theory of the excitation and amplification of longitudinal-optical phonons in degenerate semiconductors under an intense laser field. PMID- 9938836 TI - Picosecond spectroscopy of excitons and biexcitons in ZnO at high density. PMID- 9938837 TI - Electronic structure of point defects on oxide surfaces. PMID- 9938838 TI - Optical nonlinearity, band-structure parameters, and refractive indices of some mixed chalcopyrite crystals. PMID- 9938840 TI - Low-temperature optical dephasing of rare-earth ions in inorganic glasses. PMID- 9938839 TI - Staging structures of the intercalation compounds AgxTiS2. PMID- 9938841 TI - Effects of pressure on the VK center in KCl. PMID- 9938842 TI - Low-temperature thermal expansion and specific heat of KCl containing Li tunneling states. PMID- 9938843 TI - Low-temperature thermal expansion and specific heat of KBr containing CN. PMID- 9938845 TI - Phonon focusing in tellurium dioxide. PMID- 9938844 TI - He-atom interaction with the (001) surfaces of LiF and NaCl. PMID- 9938846 TI - High-temperature light scattering and the glass transition in vitreous silica. PMID- 9938848 TI - Electronic Zeeman and Stark spectroscopy of BaClF:Sm2+ using photon-gated hole burning. PMID- 9938847 TI - Photoelectron spectra of polysilanes. PMID- 9938849 TI - Theory of microwave absorption in wide-band-gap insulators: The role of thermal phonon lifetimes. PMID- 9938850 TI - High-pressure phase transitions and the equations of state of BaS and BaO. PMID- 9938851 TI - Quadrupole interactions in graphite-hafnium chloride. PMID- 9938852 TI - Water on Si(111)7 x 7: An in situ study with electron-energy-loss and photoemission spectroscopies. PMID- 9938853 TI - Theory for self-trapped holes in rare-gas solids. I. Formalism and result for solid argon. PMID- 9938854 TI - Theory for self-trapped holes in rare-gas solids. II. Systematic change in the series of Ne to Xe and its physical origin. PMID- 9938855 TI - Comparison of x-ray absorption with x-ray photoemission of nickel dihalides and NiO. PMID- 9938856 TI - Calculation of rotational T2 relaxation in solid parahydrogen and orthodeuterium. PMID- 9938857 TI - Effects of the off-center position of the Li+ ion on the optical properties of the FA center in KCl. PMID- 9938859 TI - Electronic polarizability of small sodium clusters. PMID- 9938858 TI - Natural birefringence in alkali halide single crystals. PMID- 9938861 TI - Theory of the quantum size effect in simple metals. PMID- 9938860 TI - Localization properties of incommensurate disordered one-dimensional systems. PMID- 9938862 TI - Vibrational excitation in gas-surface collisions. PMID- 9938863 TI - Conductances of filled two-dimensional networks. PMID- 9938864 TI - Aharonov-Bohm effect in thin, normal-metal films containing small voids. PMID- 9938866 TI - High-resolution infrared reflection absorption spectroscopy with a continuously tunable infrared laser: CO on Ru(001). PMID- 9938865 TI - Liquid Ge: A strongly coupled liquid with negligible bridge contributions to the structure factor. PMID- 9938867 TI - Metallization and Schottky-barrier formation. PMID- 9938869 TI - Interlayer acoustic phonons in the layered compound TiS2. PMID- 9938868 TI - Addendum to "Thomas-Fermi dielectric screening of pseudocharges in semiconductors" PMID- 9938870 TI - DX center: Crossover of deep and shallow states in Si-doped AlxGa1-xAs. PMID- 9938872 TI - Molecular-dynamics simulation of NH4 + reorientations in NH4Cl. PMID- 9938871 TI - Angle-resolved photoemission study of black phosphorus: Interlayer energy dispersion. PMID- 9938873 TI - Erratum: Model adsorption potentials for He and Ne on graphite PMID- 9938874 TI - Discontinuity of the exchange-correlation potential from a density-functional viewpoint. PMID- 9938875 TI - Surface phonon dispersion of platinum (111). PMID- 9938876 TI - Landau levels above the optical-phonon continuum in two and three dimensions. PMID- 9938877 TI - Evidence for bulk "narrow-band noise" in NbSe3: Thermal-gradient studies. PMID- 9938878 TI - Core-level and valence-band photoemission study of granular platinum films. PMID- 9938879 TI - Kinetics of staging transitions: A neutron diffraction study of pressure-quenched potassium-intercalated graphite. PMID- 9938880 TI - Electronic structure of the Bi(111) surface. PMID- 9938882 TI - Final-state mixing and charge neutralization by tunneling: A photoemission study of metal-rare-gas systems. PMID- 9938881 TI - Effects of dislocation scattering on the low-temperature thermal conductivity of pure Cu. PMID- 9938883 TI - Direct measure of surface impurity scattering by angle-resolved photoemission. PMID- 9938885 TI - Magnetotransport in the heavy-fermion compound U2Zn17. PMID- 9938884 TI - Impurity diffusion in icosahedral Al-Mn. PMID- 9938886 TI - Relativistic effects on the surface electronic structure of Cu(001): Observation of a spin-orbit-gap surface state. PMID- 9938887 TI - Correlation between ligand density of states and 5f delocalization in uranium intermetallic compounds. PMID- 9938888 TI - Photocurrent spectroscopy of GaAs/AlxGa1-xAs quantum wells in an electric field. PMID- 9938889 TI - Hot-electron transport in GaAs-AlGaAs heterojunctions. PMID- 9938890 TI - Photoluminescence, absorption, and Raman spectra of a polydiacetylene monolayer. PMID- 9938891 TI - Well-size dependence of exciton blue shift in GaAs multiple-quantum-well structures. PMID- 9938892 TI - Magnetoresistance in a two-dimensional impurity band. PMID- 9938893 TI - Photocarrier dynamics in compensated hydrogenated amorphous silicon. PMID- 9938894 TI - Self-compensation and the absence of doping in amorphous GaAs. PMID- 9938896 TI - (2 x 2) reconstructions of the {111} polar surfaces of GaAs. PMID- 9938895 TI - X-ray standing-wave determination of surface structure: Au on Si(111). PMID- 9938897 TI - Modulated-reflectance spectroscopy of InP doping superlattices. PMID- 9938899 TI - Anisotropy of magnetic polarons bound to acceptors in Cd1-xMnxSe. PMID- 9938898 TI - Quasiparticle states and the fractional quantum Hall effect. PMID- 9938900 TI - Strain-induced metal-insulator transition of the Ge(111) surface. PMID- 9938902 TI - Perturbative interpretation of the heterojunction band-offset problem. PMID- 9938901 TI - Electronic properties of an electron-attractive complex neutral defect in GaAs. PMID- 9938903 TI - Many-electron treatment of the off-center substitutional O in Si. PMID- 9938904 TI - Low-temperature homogeneous linewidths of Yb3+ in inorganic glasses. PMID- 9938905 TI - Conductivity and structure of thin oxide layers grown on a metal substrate: Scanning-tunneling microscopy in NiO on Ni(100). PMID- 9938906 TI - Structural significance of Raman spectra of OH- and F-doped vitreous silica. PMID- 9938907 TI - Anomalous electron-spin relaxation in amorphous silicon. PMID- 9938908 TI - Preliminary EPR study of a solid-solid critical point in CaCO3 near 200 degreesC and 1.5 GPa. PMID- 9938909 TI - Strain broadening of the dangling-bond resonance at the (111)Si-SiO2 interface. PMID- 9938910 TI - High-resolution angle-resolved positron reemission spectra from metal surfaces. PMID- 9938911 TI - Site-selective spectroscopy via energy up-conversion in CaF2:Pr3+ PMID- 9938912 TI - Quasistationary state and its decay to equilibrium in the pulsed spin locking of a nuclear quadrupole resonance. PMID- 9938913 TI - 151Eu Mossbauer study of the EuxLa PMID- 9938914 TI - Theoretical analysis of NMR and neutron scattering data in cerium compounds. PMID- 9938915 TI - Bipolaronic superconductivity: Thermodynamics, magnetic properties, and possibility of existence in real substances. PMID- 9938916 TI - Spin waves and spin diffusion in Fermi liquids: Bounds on effective diffusion coefficients. PMID- 9938917 TI - Far-infrared properties and characterization of superconducting Nb3Ge. PMID- 9938918 TI - Scattering of helium atoms by liquid helium. PMID- 9938919 TI - Random-walk approach to the two-component random-conductor mixture: Perturbing away from the perfect random resistor network and random superconducting-network limits. PMID- 9938920 TI - New superconducting scanning phonon spectroscopy. PMID- 9938921 TI - Hartree and Jastrow approximations for monolayer solids of Ne, D2, H2, 4He, and 3He. PMID- 9938922 TI - Elementary excitations in quantum Bose fluids: Application to liquid 4He. PMID- 9938923 TI - Dynamics of the intermediate state in nonequilibrium superconductors. PMID- 9938924 TI - Electromagnetic absorption for a superconductor with states in the gap. PMID- 9938925 TI - Theory of the upper critical field of superconducting superlattices. PMID- 9938926 TI - Criticality and superfluidity in a dilute Bose fluid. PMID- 9938927 TI - Hydrodynamic modes of superfluid helium adsorbed on Nuclepore. PMID- 9938928 TI - Superconductivity and magnetism of a body-centered tetragonal ErRh4B4 single crystal. I. Metamagnetism under the fourfold magnetic anisotropy. PMID- 9938929 TI - Superconductivity and magnetism of a body-centered tetragonal ErRh4B4 single crystal. II. Large anisotropy of Hc2. PMID- 9938931 TI - Vortex contribution to the specific heat in the two-dimensional XY model. PMID- 9938930 TI - Prediction of chaos in a Josephson junction by the Melnikov-function technique. PMID- 9938932 TI - Magnetization of Hg1-xMnxTe. PMID- 9938934 TI - Continuum percolation of permeable objects. PMID- 9938933 TI - Modified hyperscaling relation for phase transitions under random fields. PMID- 9938935 TI - New algorithm for high-temperature series: The planar rotator model. PMID- 9938936 TI - Effective discrete-time dynamics in Monte Carlo simulations. PMID- 9938937 TI - Electronic structure of ZnTe and CdTe under pressure. PMID- 9938939 TI - Kinetics of domain growth: The relevance of two-step quenches. PMID- 9938938 TI - Observation of isotropic critical spin fluctuations in Gd. PMID- 9938940 TI - Multilayer adsorption of oxygen on graphite near the triple point. PMID- 9938941 TI - Two-dimensional Ising model in an annealed random field: Exact results. PMID- 9938943 TI - Hysteresis of Neel-line motion and effective width of 180 degrees Bloch walls in bulk iron. PMID- 9938942 TI - Critical behavior of coupled XY models. PMID- 9938944 TI - Electronic-structure calculations of binary-alloy phase diagrams. PMID- 9938945 TI - Order parameter and critical exponent for the pressure-induced phase transitions in ReO3. PMID- 9938946 TI - Kondo state and pressure-induced ferromagnetism in CeZn. PMID- 9938949 TI - Conductivity in percolation networks with broad distributions of resistances. PMID- 9938947 TI - Saturation of Ruderman-Kittel-Kasuya-Yosida interaction damping in high resistivity spin glasses. PMID- 9938948 TI - Properties of one-dimensional quasilattices. PMID- 9938951 TI - Solitary waves in elastic ferromagnets. PMID- 9938950 TI - Thermodynamics of field-induced spin-density-wave states in Bechgaard salts. PMID- 9938953 TI - Segregation and shape stability in small bimetallic particles. PMID- 9938952 TI - Transverse-wave model of the distorted phases of the TaTe4 and NbTe4 structures. PMID- 9938954 TI - Magnetism in the linear-chain antiferromagnet RbCoCl3 PMID- 9938955 TI - Molecular-dynamic study of the molecular glass model for Rb1-x(ND4)xD2PO4. PMID- 9938956 TI - Low-temperature behavior of the S=(1/2) ferromagnetic Heisenberg chain. PMID- 9938957 TI - Proximity effects in magnetic interfaces. PMID- 9938958 TI - Thermodynamics of the metal-insulator transition: Discontinuous transitions in the paramagnetic phase. PMID- 9938960 TI - Thermodynamic properties of the two-dimensional quantum Heisenberg ferromagnet and the effects of bond dilution. PMID- 9938959 TI - Theory and experiment on the 1/f gamma noise in p-channel metal-oxide semiconductor field-effect transistors at low drain bias. PMID- 9938961 TI - Triangular-spin, kagome plane in jarosites. PMID- 9938963 TI - Fractal character of wave functions in one-dimensional incommensurate systems. PMID- 9938962 TI - Dynamical properties of long-wavelength interface fluctuations during nucleation dominated crystal growth. PMID- 9938964 TI - Kinetic growth of polyelectrolytes: Long-range true self-avoiding walks. PMID- 9938965 TI - Thermodynamic basis for dielectric relaxation in complex materials. PMID- 9938966 TI - Order of wetting transitions. PMID- 9938967 TI - Neutron scattering study of freezing in Rb1-x(ND4)xD2PO 4. PMID- 9938968 TI - Electronic structure of the strongly-exchange-enhanced paramagnet Ni3Ga. PMID- 9938970 TI - Percolation conductivity exponent t to second order in epsilon =6-d. PMID- 9938969 TI - Evidence for a magnetic contribution to the electrical resistivity in amorphous Fe80B20-xCx alloys. PMID- 9938971 TI - Phase transition to long-range ferromagnetism in Au82Fe18 and the associated critical exponents. PMID- 9938973 TI - Elastic and magnetic interactions in a narrow twofold-degenerate band. PMID- 9938972 TI - Experimental and theoretical investigations of the magnetic susceptibility and anisotropy of Na3Pr(C4H4O5)3 PMID- 9938974 TI - Verification of the Aharonov-Bohm effect in superconductors by use of a toroidal flux geometry. PMID- 9938975 TI - Knight shift and spin-lattice relaxation for 63Cu and 31P in amorphous Ni-Cu-P alloys. PMID- 9938976 TI - Estimation of T1 for Co2+ ions from the temperature variation of the ESR linewidths for Mn2+ in Cs2Co(SeO4)2 PMID- 9938977 TI - Theory of stimulated hyper-Raman scattering in noncentrosymmetric crystals. PMID- 9938978 TI - Vibrational energies from nuclear gamma resonant scattering: Measurement and comparison with neutron inelastic scattering. PMID- 9938980 TI - Correlation between the hyperfine-parameter distributions determined by 57Fe Mossbauer spectroscopy. PMID- 9938979 TI - Observation of new ESR signals in undoped, slowly deposited a-Si and a-Si:H. PMID- 9938981 TI - Ejection process in collisional sputtering. PMID- 9938983 TI - Cluster-method study of phase separation in 3He-4He mixtures. PMID- 9938982 TI - Experimental values of the gap exponents for the paramagnetic region. PMID- 9938985 TI - Fractal surface dimensionality and finite-size scaling at the superfluid transition of confined 4He. PMID- 9938984 TI - Superconductivity and electronic instability at high pressure in Sc5Co4Si10-type compounds. PMID- 9938987 TI - Magnetic properties of W-Fe alloys. PMID- 9938986 TI - Anomalous critical spin dynamics in Gd: A revision. PMID- 9938988 TI - Elusiveness of the prewetting transition. PMID- 9938990 TI - Evidence for depinning of a Wigner crystal in Hg-Cd-Te. PMID- 9938989 TI - Signs of magnetic surface anisotropy constants. PMID- 9938991 TI - Remanent magnetization of the infinite-range Ising spin glass. PMID- 9938992 TI - Validity of hyperscaling for the d=3 Ising model. PMID- 9938994 TI - Calculated equation of state of InAs. PMID- 9938993 TI - Dielectric breakdown in three dimensions: Results of numerical simulation. PMID- 9938995 TI - Monoclinic-amorphous-cubic phase transitions in tetracyanoethylene under high pressure. PMID- 9938996 TI - Comment on "Monte Carlo studies of the quantum XY model in two dimensions" PMID- 9938997 TI - Reply to "Comment on 'Monte Carlo studies of the quantum XY model in two dimensions' " PMID- 9938999 TI - Thermodynamic properties of the infinite-range Ashkin-Teller model. PMID- 9938998 TI - Comment on "Excitations in the one-dimensional anisotropic classical Heisenberg chain" PMID- 9939000 TI - Erratum: Thermal and nuclear hyperfine properties of Ho(OH)3 PMID- 9939001 TI - Flux sensitivity of a piecewise normal and superconducting metal loop. PMID- 9939002 TI - Dynamic charge states of energetic He ions in silicon single crystals. PMID- 9939003 TI - Direct evidence of stress-induced site change of H in V observed by the channeling method. PMID- 9939004 TI - Surfaces of superfluid 3He-B. PMID- 9939005 TI - Experiments on intrinsic and thermally induced chaos in an rf-driven Josephson junction. PMID- 9939006 TI - Critical cutting force between flux vortices in a type-II superconductor. PMID- 9939007 TI - Theory of superconductivity in palladium-noble-metal hydrides. PMID- 9939008 TI - Hall effect in the heavy-fermion superconductor UPt3. PMID- 9939009 TI - Effect of quantum fluctuations on one-dimensional electron-phonon systems: The Su Schrieffer-Heeger model. PMID- 9939011 TI - Melting transitions of CF4 on graphite. PMID- 9939012 TI - Model for chaotic dynamics of the perpendicular-pumping spin-wave instability. PMID- 9939010 TI - Multilayer adsorption and wetting: Ethylene on graphite. PMID- 9939014 TI - Angle-resolved photoemission study of the orientation and electronic interactions of romanCO+K/Ru(001) in the low-coverage regime. PMID- 9939013 TI - Confinement-deconfinement transitions in a model of interacting dislocations. PMID- 9939016 TI - Surface-polariton-like waves guided by thin, lossy metal films. PMID- 9939015 TI - Low-order anharmonic contributions to the internal energy of the one-component plasma. PMID- 9939017 TI - Fano core resonances and augmented continua of Zn adsorbed on and dissolved in alkali metals. PMID- 9939018 TI - Low-temperature specific heat of LixNbS2 intercalation compounds. PMID- 9939019 TI - Magnetoplasmons in a two-dimensional electron fluid: Disk geometry. PMID- 9939020 TI - Interpretation of electronic excitations in coordinated CO systems as observed by electron-energy-loss spectroscopy. PMID- 9939022 TI - Physical aspects of relaxation and shake-up effects in x-ray photoemission spectroscopy and core -->2 pi absorption spectra of CO chemisorbed on Ni(111). PMID- 9939021 TI - Hydrogenic image-potential states: A critical examination. PMID- 9939023 TI - Final-state effects in photoemission from filled, narrow bands in metals: A two level many-electron model. PMID- 9939024 TI - Invariant-imbedding approach to resistance fluctuations in disordered one dimensional conductors. PMID- 9939025 TI - Effects of electron correlation and geometrical structure on stability of metal clusters. PMID- 9939027 TI - Electronic properties of expanded cesium. PMID- 9939026 TI - High-resolution inverse-photoemission study of a clean and an oxidized Ag-Mn(111) random substitutional alloy. PMID- 9939028 TI - Multiple-scattering approach to the x-ray-absorption spectra of 3d transition metals. PMID- 9939029 TI - Surface dependence of the Cr(001) 3s photoemission line shape. PMID- 9939030 TI - Point defects in ordered metallic compounds. I. Electronic-structure calculation by the linear-muffin-tin-orbital method. PMID- 9939032 TI - Coherent orientation relationship between an icosahedral phase and a cubic alpha phase in melt-spun Al-Si-Mn. PMID- 9939031 TI - Point defects in ordered metallic compounds. II. Self-consistent studies of vacancies in FeAl. PMID- 9939034 TI - Structural transitions and metallization in compressed solid argon. PMID- 9939033 TI - Simple theory of atom-surface scattering. PMID- 9939035 TI - Reflectance of a rough insulating overlayer on a metal with a nonlocal optical response. PMID- 9939037 TI - Grain-size effects in the parallel-band absorption spectrum of aluminum. PMID- 9939036 TI - Off-shell self-energy effects and the dynamic structure factor of an electron liquid. PMID- 9939039 TI - Photoemission and high-resolution electron-energy-loss spectroscopy studies of CO chemisorption on thin Pd films on Au(111). PMID- 9939038 TI - Surface and soliton charge in insulating systems. PMID- 9939040 TI - Contributions of one- and two-phonon processes to the resistivity of tetrathiafulvalene-tetracyanoquinodimethane. PMID- 9939042 TI - Electronic structure of iridium silicides. PMID- 9939041 TI - Noble- and transition-metal clusters: The d bands of silver and palladium. PMID- 9939044 TI - Valence electronic structure of AuZn and AuMg alloys derived from a new way of analyzing Auger-parameter shifts. PMID- 9939043 TI - Theory of finite-temperature screening in a disordered two-dimensional electron gas. PMID- 9939045 TI - Neutron scattering in disordered alloys: Coherent and incoherent intensities. PMID- 9939046 TI - Structure of GeSsub2 glass: Spectroscopic evidence for broken chemical order. PMID- 9939047 TI - Quantitative model of reactive metal-semiconductor interface growth using high resolution photoemission results. PMID- 9939048 TI - Low-temperature divergence of the charge-density-wave viscosity in K0.30MoO3, (TaSe4)2I, and TaS3. PMID- 9939049 TI - Optical absorption in semiconducting quantum-well structures: Indirect interband transitions. PMID- 9939050 TI - Electron-phonon interactions and charge-density-wave formations in strong magnetic fields. PMID- 9939051 TI - Optical constants of GaAs-AlxGa1-xAs superlattices and multiple quantum wells. PMID- 9939052 TI - Resonant Raman scattering and interference effects of LO phonons at the E0+ Delta 0 gap of InP. PMID- 9939053 TI - Functional integral approach to positionally disordered systems. PMID- 9939054 TI - Real-space inversion of the dielectric-response function of a superlattice. PMID- 9939055 TI - Time evolution of Bloch electrons in a homogeneous electric field. PMID- 9939057 TI - Luminescence linewidths of excitons in GaAs quantum wells below 150 K. PMID- 9939056 TI - Phonon-induced lifetime broadenings of electronic states and critical points in Si and Ge. PMID- 9939058 TI - Influence of thin SiO2 interlayers on chemical reaction and microstructure at the Ni/Si(111) interface. PMID- 9939059 TI - Electronic properties and chemistry of Ti/GaAs and Pd/GaAs interfaces. PMID- 9939060 TI - In-diffusion of Pt in Si from the PtSi/Si interface. PMID- 9939061 TI - Diffusion and relaxation of energy in disordered organic and inorganic materials. PMID- 9939062 TI - New surface states on the annealed Ge(111) surface. PMID- 9939063 TI - Selective resonance enhancement at indirect gaps in GaP and GaAs0.11P0.89. PMID- 9939066 TI - Angular dependence of the quantum oscillations in the diluted magnetic semiconductor Hg1-xFexSe. PMID- 9939064 TI - Improved assessment of structural properties of AlxGa1-xAs/GaAs heterostructures and superlattices by double-crystal x-ray diffraction. PMID- 9939065 TI - Analytic solution of the Boltzmann equation with applications to electron transport in inhomogeneous semiconductors. PMID- 9939067 TI - Effect of the polaron-induced nonparabolicity of the energy-momentum relation on the dynamics of transport electrons. PMID- 9939068 TI - Monte Carlo study of electronic transport in Al1-xGaxAs/GaAs single-well heterostructures. PMID- 9939070 TI - Subspace Hamiltonian technique. PMID- 9939069 TI - Electronic subbands of a delta doping layer in GaAs in a parallel magnetic field. PMID- 9939071 TI - Transverse magnetoconductivity of quasi-two-dimensional semiconductor layers in the presence of phonon scattering. PMID- 9939073 TI - Nature of the state of stress produced by xenon and some alkali iodides when used as pressure media. PMID- 9939072 TI - Hot-electron luminescence and polarization in GaAs1-xPx alloys. PMID- 9939075 TI - Electron-energy-loss near-edge structure of Be2C. PMID- 9939074 TI - Specific-heat study of the phonon-fracton crossover in glassy ionic conductors. PMID- 9939076 TI - Effective masses and surface-corrugation energies of bound-state levels in atom surface scattering. PMID- 9939077 TI - Relative Raman scattering cross sections for chemisorbed and physisorbed pyridine molecules adsorbed on surface-enhanced Raman-scattering-active Ag films in ultrahigh vacuum: Local-field effects in the low-coverage regime. PMID- 9939078 TI - Coexistence of biholes and electron-bihole complexes in the photoemission final state in cuprous halides. PMID- 9939079 TI - Defect-mediated hydrogen-bond instability of poly(dG)-poly(dC). PMID- 9939081 TI - Mobility of cations in magnesium aluminate spinel. PMID- 9939080 TI - Characterization of insulators by high-resolution electron-energy-loss spectroscopy: Application of a surface-potential stabilization technique. PMID- 9939082 TI - Persistent spectral hole burning for R' color centers in LiF crystals: Statics, dynamics, and external-field effects. PMID- 9939083 TI - Orientation of nitrate molecules in graphite-HNO3 residue compounds. PMID- 9939084 TI - Relative Raman intensities of the folded modes in SiC polytypes. PMID- 9939085 TI - Resistive anomalies and phase transitions in potassium-intercalated benzene derived graphite fibers. PMID- 9939087 TI - Energy dependence of the mean free path of excess hot electrons in solid xenon in the elastic scattering region. PMID- 9939086 TI - Laser-induced metal cluster growth and segregation in granular metal-insulator systems. PMID- 9939088 TI - Optical reflectivity and electronic structure of layered cadmium halides. PMID- 9939089 TI - Structural properties of potassium-ammonia liquids in graphite. PMID- 9939090 TI - Unoccupied electronic states of graphite as probed by inverse-photoemission and tunneling spectroscopy. PMID- 9939092 TI - Brillouin-scattering investigation of the mixed system KBr1-x(CN)x. PMID- 9939091 TI - He-Si(100) potential: Charge superposition and model structures. PMID- 9939093 TI - Mechanism of nonresonant energy transfer between ions in SrF2:Er3+ PMID- 9939095 TI - Surface resonance states of physisorbed molecules. PMID- 9939094 TI - Acoustical activity in the framework of the rotation-gradient theory of elasticity. PMID- 9939096 TI - Calculation of three-body dispersive energies: Extrapolation method and application to crystals of isotropic and anisotropic bodies. PMID- 9939098 TI - Calculation of the mobility of electrons injected in liquid argon. PMID- 9939097 TI - Transition dipole-dipole coupling between the NO stretching vibrations of nitroprusside ions in Sr PMID- 9939099 TI - Formation of concentric rings on the flaked surface of Mylar due to 250-keV H+ ion implantation. PMID- 9939100 TI - Multiple steady states on an adsorbent surface. PMID- 9939101 TI - Model-potential approach to the lattice dynamics of barium. PMID- 9939102 TI - Sample length and frequency dependence of the voltage-oscillation amplitude in NbSe3. PMID- 9939103 TI - Effect of an oxide coating on the infrared and visible absorption of small silver particles. PMID- 9939104 TI - Anomalous scattering effects on the invariant phases in near-absorption-edge multiple diffraction of x rays. PMID- 9939105 TI - Superlattice with multiple layers per period. PMID- 9939106 TI - Magnetotransport properties and subband structure of the two-dimensional hole gas in GaAs-Ga1-xAlxAs heterostructures. PMID- 9939107 TI - Dielectric hysteresis and relaxation in the charge-density-wave compound K0.3MoO3. PMID- 9939108 TI - Weak-field g factor of the two-dimensional electron gas at the (In,Ga)As/InP interface. PMID- 9939109 TI - Structural map for the crystals with an average of five valence electrons per atom. PMID- 9939110 TI - Shallow donors in multiple-well GaAs-Ga1-xAlxAs heterostructures. PMID- 9939111 TI - Shallow donors in multiple-well GaAs-Ga1-xAlxAs heterostructures. PMID- 9939112 TI - Photoelastic coefficients and deformation-potential constants of ZnSe crystals. PMID- 9939113 TI - New vibrational modes in the far-infrared spectra of germanium diselenide. PMID- 9939114 TI - Antisite-related defects in plastically deformed GaAs. PMID- 9939115 TI - Temperature-induced commensurate-incommensurate transition of submonolayer krypton on graphite. PMID- 9939116 TI - Adsorption kinetics and thermal desorption measurements for oxygen layers on graphite. PMID- 9939118 TI - Effective elastic constants of superlattices of any symmetry. PMID- 9939117 TI - Vibronic properties of manganese in calcium fluoride. PMID- 9939120 TI - High-pressure study of photoluminescence in indium phosphide at low temperature. PMID- 9939119 TI - Two-level-system spectrum and extrinsic disorder. PMID- 9939121 TI - Elastic and electromechanical behavior of Cd1-xMnxTe. PMID- 9939122 TI - Positronium at surfaces. PMID- 9939123 TI - Low-temperature phonon-limited electron mobility in modulation-doped heterostructures. PMID- 9939124 TI - Unrenormalized ultrasound attenuation in the heavy-fermion state. PMID- 9939125 TI - Local bonding geometry of O(2 x 1) on Ni(110): A surface extended x-ray absorption fine-structure study. PMID- 9939126 TI - Multiple-scattering theory for clusters of nonoverlapping potentials of arbitrary shape. PMID- 9939128 TI - Electronic structure and sign reversal of the Hall coefficient in amorphous CuZr alloys. PMID- 9939127 TI - Surface-enhanced Raman scattering of obliquely evaporated Ag films. PMID- 9939129 TI - Positron-annihilation study of voids in a-Si and a-Si:H. PMID- 9939130 TI - Folded acoustic phonons in Si-SixGe1-x superlattices. PMID- 9939131 TI - High-resolution photoluminescence and reflection studies of GaAs-AlxGa1-xAs multi quantum-well structures grown by molecular-beam epitaxy: Determination of microscopic structural quality of interfaces. PMID- 9939132 TI - Magnetic-field-induced metal-nonmetal transition in GaAs-Ga1-xAlxAs heterostructures. PMID- 9939133 TI - Comparative study of the effect of an electric field on the photocurrent and photoluminescence of GaAs-GaAlAs quantum wells. PMID- 9939135 TI - Observation of strongly wave-vector-dependent Raman scattering by LO phonons in GaAs near the E0 band gap. PMID- 9939134 TI - Electronic Raman scattering of the negative charge state of the 78-meV double acceptor in GaAs. PMID- 9939136 TI - Anomalous Ce-valence-state disparity between crystalline and amorphous transition metal compounds. PMID- 9939137 TI - Carrier confinement and special crystallite dimensions in layered semiconductor colloids. PMID- 9939138 TI - Vibronic polymers: A novel chemical species. PMID- 9939139 TI - Phonon effects on the transport properties in the fractionally quantized Hall regime. PMID- 9939140 TI - Tunneling dynamics of photogenerated carriers in semiconduc- tor superlattices. PMID- 9939141 TI - Pressure effect on the luminescence from the deep level in gallium arsenide. PMID- 9939142 TI - Ab initio calculation of the low-frequency Raman cross section in silicon. PMID- 9939143 TI - Fundamental absorption edge of PbF2 and Cd1-xPbx PMID- 9939144 TI - Finite-band continuum model of polyacetylene. PMID- 9939145 TI - Determination of the quantum density matrix from experiment: An application to positron annihilation. PMID- 9939146 TI - Transport of magnetization in inhomogeneously broadened spin systems. PMID- 9939147 TI - 83Kr in solid krypton. I. Defects and diffusion. PMID- 9939149 TI - Electric field gradient at 57Fe in scandium and systematics of the electric field gradient at impurities in transition-metal hosts. PMID- 9939148 TI - 83Kr in solid krypton. II. Rotating-frame relaxation and spectral diffusion. PMID- 9939150 TI - Rainbow effect in ion channeling. PMID- 9939151 TI - Rainbow effect in axial ion channeling. PMID- 9939152 TI - Spin-wave spectra of insulating films: Comparison of exact calculations and a single-wave-vector model. PMID- 9939153 TI - Impurity resonances in LiY1-xRxF PMID- 9939154 TI - Microscopic calculations of the excitation spectrum of one 3He impurity in liquid 4He. PMID- 9939155 TI - Response functions and collective modes of superfluid 3He-B in strong magnetic fields. PMID- 9939156 TI - Flux periodicity in superconducting rings: Comparison to loops with Josephson junctions. PMID- 9939157 TI - Critical and tricritical microscopic exponents of a Fermi-Bose mixture. PMID- 9939158 TI - Superfluid transition of 4He films adsorbed in porous materials. PMID- 9939159 TI - Strong-coupling theory of the upper critical magnetic field Hc2. PMID- 9939160 TI - Origin of the anisotropic upper critical fields in single crystals of superconducting rare-earth ternary borides. PMID- 9939161 TI - Maximum 2 Delta 0/kBTc for electron-phonon superconductors. PMID- 9939162 TI - Strong-coupling corrections to Bardeen-Cooper-Schrieffer ratios. PMID- 9939163 TI - Theory of coexistence between itinerant-electron antiferromagnetism and superconductivity. PMID- 9939164 TI - Simple model for etching. PMID- 9939165 TI - Enhancement of the spin susceptibility in disordered interacting electrons and the metal-insulator transition. PMID- 9939166 TI - Structural stability of phases of black phosphorus. PMID- 9939168 TI - Hyperscaling, dimensional reduction, and the random-field Ising model. PMID- 9939167 TI - Free energy of a macromolecule in a confined domain. PMID- 9939169 TI - Renormalization-group classification of continuous structural phase transitions induced by six-component order parameters. PMID- 9939170 TI - Classification of continuous phase transitions and stable phases. II. Four dimensional order parameters. PMID- 9939171 TI - Static universality class implied by the critical exponents of Gd. PMID- 9939172 TI - Antiferromagnetic resonance in tetramethyltetrathiafulvalene (TMTTF) salts. PMID- 9939173 TI - Local-anisotropy and spin-nature effects in ferrimagnetic Ising chains: New compensation phenomena. PMID- 9939174 TI - Crystal structure and magnetic properties of piperazinium hexadichlorocuprate: A new S=(1/2) antiferromagnetic chain with alternating exchange. PMID- 9939176 TI - New results on Trotter-like approximations. PMID- 9939175 TI - Influence of a frozen defect density wave on an incommensurate modulation. PMID- 9939177 TI - Dynamics of branched domain structures. PMID- 9939178 TI - Biquadratic exchange from susceptibility data in classical one-dimensional Heisenberg systems. PMID- 9939179 TI - Anisotropic surface free energy and the roughening transition of the diffuse crystal-liquid interface. PMID- 9939180 TI - Lattice model for elastic ferroelectric crystals: Microscopic approach. PMID- 9939181 TI - Lattice model for elastic ferroelectric crystals: Continuum approximation. PMID- 9939182 TI - Critical behavior in the Ising antiferromagnet MnTe2. PMID- 9939183 TI - Critical ultrasonic behavior near the normal-incommensurate phase transition in NaNO2. PMID- 9939184 TI - Intrinsic domain-wall pinning and spatial chaos in continuum models of one dimensionally incommensurate systems. PMID- 9939185 TI - Thermodynamic properties of a three-dimensional defect system. PMID- 9939186 TI - Magnetic structure of beta -oxygen. PMID- 9939187 TI - Linear transverse susceptibility of Ising systems. PMID- 9939188 TI - Mean-field treatment of arbitrary anisotropic ferromagnetic spin Hamiltonians. PMID- 9939189 TI - Fractal sandstone pores: Automated measurements using scanning-electron microscope images. PMID- 9939191 TI - Pressure-induced electronic and structural phase transitions in solid hydrogen. PMID- 9939190 TI - Magnetic order in a dimerized singlet-triplet system: A neutron scattering study of Cs3Cr2I9. PMID- 9939192 TI - Spin freezing below the nearest-neighbor percolation concentration in Cd1-xMnxTe and Cd1-xMnxSe. PMID- 9939193 TI - Viscous relaxation in metallic glasses. PMID- 9939194 TI - Local environment of Li intercalated in Mo6SezS8-z as probed using electrochemical methods. PMID- 9939195 TI - Finite-size effects in the spherical model of ferromagnetism: Zero-field susceptibility under antiperiodic boundary conditions. PMID- 9939196 TI - Critical exponents, amplitudes, and correction to scaling in nickel measured by neutron depolarization. PMID- 9939197 TI - Effective properties of two-phase disordered composite media: II. Evaluation of bounds on the conductivity and bulk modulus of dispersions of impenetrable spheres. PMID- 9939198 TI - Ferroelectric microregions and Raman scattering in KTaO3. PMID- 9939199 TI - Neutron-diffraction study on the kinetics of the atomic order in Ni3Mn. PMID- 9939201 TI - Low-temperature phases of an Ising model on the hcp lattice with competing interactions. PMID- 9939200 TI - Percolation at the surface of semi-infinite two-dimensional lattices. PMID- 9939202 TI - Ising model on a quasiperiodic chain. PMID- 9939203 TI - Low-temperature martensitic phase transition of bcc lithium. PMID- 9939204 TI - Magnetic ordering in the randomly mixed quadratic-layer antiferromagnet with competing anisotropies K2CoxFe1-xF4. PMID- 9939205 TI - Integrability of a general model for intermediate valence. PMID- 9939206 TI - Measurement of acoustic phonons in UBe13. PMID- 9939207 TI - Stress effects on the ESR spectra of rare earths in polycrystalline thin films. PMID- 9939208 TI - Hydrogen-silicon nuclear spin correlations in alpha -Si:H: A two-dimensional NMR study. PMID- 9939209 TI - Zener tunneling and dissipation in small loops. PMID- 9939210 TI - Surface critical behavior near the Lifshitz point of a semi-infinite system. PMID- 9939211 TI - Extended universality and the question of spin on hierarchical lattices. PMID- 9939212 TI - Ground state of antiferromagnetic Heisenberg rings studied by the projector method. PMID- 9939213 TI - Polarized neutron scattering from CeCu2Si2 in applied magnetic fields. PMID- 9939214 TI - Low-temperature specific heat of the diluted magnetic semiconductors M1-x(IIb PMID- 9939215 TI - Truncation errors in the Monte Carlo renormalization group: A comparative study. PMID- 9939216 TI - Dipole-dipole interactions and two-dimensional magnetism. PMID- 9939218 TI - Kinetics of ordering in the order-disorder phase transition of AlCl3-intercalated graphite studied using ESR. PMID- 9939217 TI - Erratum: Determination of multicritical points for lattice-gas models by finite size scaling of the susceptibility PMID- 9939219 TI - Anisotropic electrical resistivity of the magnetic heavy-fermion superconductor URu2Si2. PMID- 9939220 TI - Spin-glass response near the glass temperature. PMID- 9939221 TI - Quenched disorder in Josephson-junction arrays in a transverse magnetic field. PMID- 9939222 TI - Effect of adsorbate binding sites on surface-reconstruction phase diagrams: O/W(001) and H/W(001). PMID- 9939223 TI - Anderson localization and breakdown of hydrodynamics in random ferromagnets. PMID- 9939224 TI - Finite-length calculations of eta and phase diagrams of quantum spin chains. PMID- 9939225 TI - Quantum versus classical polarizability in one-dimensional percolation models. PMID- 9939226 TI - Anisotropic magnetoresistance in a Fermi glass. PMID- 9939227 TI - Photon-gated spectral hole burning in LiGa5O8:Co2+ PMID- 9939228 TI - Lattice-location studies of cerium ions implanted into vanadium single crystals. PMID- 9939229 TI - Electronic structure and x-ray-absorption spectra of wustite Fe1-xO. PMID- 9939230 TI - NMR study of the metal-insulator transition in the compensated sodium-tungsten bronze, NaxTayW1-yO3. PMID- 9939231 TI - Lattice and electronic contributions to the quadrupole interaction of trivalent europium. PMID- 9939232 TI - Theory of charge exchange in the scattering of molecular ions from simple metals. PMID- 9939233 TI - Resonant transition rates for charge transfer between diatomic molecular ions and simple metals. PMID- 9939234 TI - Electron-spin-resonance-transient spectroscopy. PMID- 9939235 TI - Annealing of metastable defects in hydrogenated amorphous silicon. PMID- 9939237 TI - H and H2 NMR properties in amorphous hydrogenated silicon (a-Si:H). PMID- 9939236 TI - Energy and Z2 dependences of energy straggling for fast proton beams passing through solids. PMID- 9939238 TI - Quadrupole coupling and crystal-field shielding in CaF2:Eu3+:O2- under hydrostatic pressure. PMID- 9939240 TI - Diffusion of iron in copper studied by Mossbauer spectroscopy on single crystals. PMID- 9939239 TI - Erosion of solid neon by keV electrons. PMID- 9939241 TI - Conduction-electron-spin resonance in organic conductors: alpha and beta phases of di PMID- 9939242 TI - Two-photon excitation of the 4f5d band of Pr3+ and interconfigurational energy transfer in LaF3:(Pr3+,Gd3+). PMID- 9939243 TI - Symmetry and stationary points of a free energy: The case of superfluid 3He. PMID- 9939244 TI - Anion ordering and superconducting and spin-density-wave transition temperatures in Bechgaard salts. PMID- 9939245 TI - Superconducting fluctuations, weak localization, and electron interactions in three-dimensional Nb:Si. PMID- 9939247 TI - Lattice dynamics and phonon line shapes of Pd0.9Ag0.1D0.61 at 100 K. PMID- 9939246 TI - Effect of an arbitrary dissipative circuit on the quantum energy levels and tunneling of a Josephson junction. PMID- 9939248 TI - Magnetic properties of La(FexAl1-x)13 determined via neutron scattering and Mossbauer spectroscopy. PMID- 9939249 TI - Vibrational structure of Hg PMID- 9939250 TI - Phase transitions in high-pressure 4He: A study using molecular-dynamics and Monte Carlo methods. PMID- 9939251 TI - New method for studying disordered quantum systems. PMID- 9939252 TI - Coexistence of superconductivity and long-range magnetic order in ErPd2Sn. PMID- 9939253 TI - Nonequilibrium dynamics of quasiparticles in superconductors. PMID- 9939254 TI - Electron tunneling in tantalum surface layers on niobium. PMID- 9939255 TI - Third-sound propagation in 4He films adsorbed on silicon. PMID- 9939256 TI - Tunneling effects on the escape of particles from an extremely underdamped potential well. PMID- 9939258 TI - Phase diagrams of cubic systems under uniaxial quadratic symmetry-breaking fields. PMID- 9939257 TI - Binding-potential modeling of the structural instability in PrAg1-xCux. PMID- 9939259 TI - Depolarization of rotating spins by random walks on lattices. PMID- 9939260 TI - Behavior of optic phonons in the commensurate and incommensurate phases of potassium selenate. PMID- 9939261 TI - Critical behavior of the two-dimensional XY model: A Monte Carlo simulation. PMID- 9939263 TI - Nonlinear excitations in the classical one-dimensional antiferromagnet. PMID- 9939262 TI - Gauge-invariant spin glasses. PMID- 9939264 TI - Observation of striped phases in adsorbed helium monolayers. PMID- 9939265 TI - Phase diagram of the three-state chiral clock model studied by Monte Carlo renormalization-group calculations. PMID- 9939266 TI - Finite-size interaction amplitudes and their universality: Exact, mean-field, and renormalization-group results. PMID- 9939267 TI - Anomalous diffusion on and elastic vibrations of two square hierarchical lattices. PMID- 9939268 TI - Critical behavior of Ising models with static site dilution. PMID- 9939270 TI - Germanium at high pressures. PMID- 9939269 TI - Role of fluctuations in random compressible systems at marginal dimensionality. PMID- 9939271 TI - Total-energy local-density studies of the alpha - gamma phase transition in Ce. PMID- 9939272 TI - Magnetic properties of transition-metal atoms and thin layers deposited on nonmagnetic metals. PMID- 9939273 TI - Scaling behavior of the magnetization of insulating Si:P. PMID- 9939275 TI - Effect of topological frustration on the freezing temperature. PMID- 9939274 TI - Quasicrystalline structure in two dimensions: Structural and physical properties. PMID- 9939276 TI - Low-frequency dielectric response in cubic KNbO3 studied by hyper-Raman scattering. PMID- 9939277 TI - Anomalies of hypersound velocity and attenuation in ferroelectric tris-sarcosine calcium chloride (TSCC) for small-angle and right-angle Brillouin scattering and Brillouin backscattering. PMID- 9939278 TI - Magnetoresistivity and Monte Carlo studies of magnetic phase transitions in C6Eu. PMID- 9939279 TI - Electron localization in two-dimensional percolating gold films. PMID- 9939280 TI - Slow electrons in condensed matter. PMID- 9939281 TI - Transmitted positron reemission from a thin single-crystal Ni(100) foil. PMID- 9939283 TI - Vortex dynamics of superfluid 4He-3He mixture films. PMID- 9939282 TI - Anomalous ballistic diffusion. PMID- 9939284 TI - Crossover from random-exchange to random-field critical behavior in FexZn1-xF2. PMID- 9939286 TI - Erratum: Nonlinear wave propagation in periodic systems: The driven sine-Gordon chain PMID- 9939285 TI - Spectral dimension of a fractal structure with long-range interactions. PMID- 9939287 TI - Direct observation of a two-dimensional gas of spin-polarized atomic hydrogen. PMID- 9939289 TI - Specific heat of amorphous MoxGe1-x through the metal-insulator transition. PMID- 9939288 TI - Nuclear acoustic resonance via the dynamic electric quadrupole coupling in iridium. PMID- 9939290 TI - Dynamical susceptibility of spin glasses in the fractal cluster model. PMID- 9939291 TI - Orientational behavior of molecular liquids in restricted geometries. PMID- 9939292 TI - Critical behavior of the magnetization of a d=3 random-field Ising system. PMID- 9939294 TI - Anisotropic Heisenberg chain with composite spin. PMID- 9939293 TI - Heavy-fermion behavior in a pseudobinary system: U(In PMID- 9939296 TI - Dimensional crossover in collective flux pinning. PMID- 9939295 TI - Interaction of a Bloch domain wall with the helical anisotropy induced by itself. PMID- 9939297 TI - Magnetoresistance studies in the ternary spin glass (AuxCu1-x)0.99Mn0.01. PMID- 9939298 TI - Hydrogen and deuterium decoration of a vacancy complex in Ni. PMID- 9939299 TI - Simultaneous epitaxy and substrate out-diffusion at a metal-semiconductor interface: Fe/GaAs(001)-c(8 x 2). PMID- 9939300 TI - General expression for the Coulomb interaction in the presence of a surface. PMID- 9939301 TI - Thermal attenuation in atom-surface scattering: The multiphonon contribution. PMID- 9939302 TI - Impact of ion-host interactions on the 5d-to-4f spectra of lanthanide rare-earth metal ions. I. A phenomenological crystal-field model. PMID- 9939304 TI - Theoretical study of the electronic, structural, and cohesive properties of ruthenium. PMID- 9939303 TI - Impact of ion-host interactions on the 5d-to-4f spectra of lanthanide rare-earth metal ions. II. The Ce-doped elpasolites. PMID- 9939305 TI - Theoretical study of the Debye-Waller factor in surface extended x-ray-absorption fine structure: Influence of an adsorbed monolayer. PMID- 9939306 TI - Extension of the Kubo formula for the electrical-conductivity tensor to arbitrary polarizations of the electric field. PMID- 9939307 TI - Homogeneous intermediate valence of Sm on Al(111). PMID- 9939309 TI - Radiative decay of 4d94fn+1 excited states in LaB6 and CeB6. PMID- 9939308 TI - Lattice dynamics of fcc and bcc calcium. PMID- 9939310 TI - Surface barrier in W(110). I. Self-consistent film calculations. PMID- 9939311 TI - Surface barrier in W(110). II. Low-energy electron diffraction fine-structure analysis. PMID- 9939312 TI - Photoemission studies of CdTe(100) and the Ag-CdTe(100) interface: Surface structure, growth behavior, Schottky barrier, and surface photovoltage. PMID- 9939313 TI - Effective-mass theory of simple surface states. PMID- 9939315 TI - Vibrational density of states in amorphous Ni1-xBx alloys and c-Ni2B. PMID- 9939314 TI - Experimental observation of nonuniversal behavior of the conductivity exponent for three-dimensional continuum percolation systems. PMID- 9939316 TI - Theoretical x-ray-photoemission-spectroscopy intensities of the actinide compounds UIr3,UPt PMID- 9939317 TI - First-principles phonon spectrum in bcc Ba: Three-ion forces and transition-metal behavior. PMID- 9939318 TI - Extended x-ray-absorption fine-structure study of Al-Mn-Ru-Si icosahedral alloys. PMID- 9939319 TI - Calculation of fluctuations and photoemission properties in a tetrahedral-cluster model for an intermediate-valence system. PMID- 9939320 TI - Morphology and structural phase transitions of Pd monolayers on Ta(110). PMID- 9939322 TI - Atomic structure of alloy surfaces. II. Ni3Al{111} PMID- 9939321 TI - Self-consistent image potential in a metal surface. PMID- 9939323 TI - Atomic structure of alloy surfaces. III. Ni3Al{110} PMID- 9939324 TI - Background removal in x-ray photoelectron spectroscopy: Relative importance of intrinsic and extrinsic processes. PMID- 9939325 TI - Temperature dependence of x-ray photoelectron diffraction from copper: Surface and bulk effects. PMID- 9939326 TI - Effect of uniaxial stress on the transport properties of TaSe3. PMID- 9939327 TI - Theory of prism-coupled light emission from tunnel junctions. PMID- 9939328 TI - Thickness variations and the Corbino effect. PMID- 9939330 TI - Modulated phases of alpha -uranium: Theoretical considerations. PMID- 9939329 TI - Classically exact overlayer dynamics: Diffusion of rhodium clusters on Rh(100). PMID- 9939332 TI - Determination of the region of the local density of states of Mg that is probed by core-core-valence Auger transitions. PMID- 9939331 TI - Comparison of exact exchange energies with local-density approximations. PMID- 9939333 TI - Nonlocal exchange energy of many-fermion systems of arbitrary dimensionality and interparticle interaction. PMID- 9939334 TI - van der Waals interaction between an atom and a surface at finite separations. PMID- 9939335 TI - Hybridization interaction between helium and a metal surface. PMID- 9939336 TI - Properties of epitaxial Au on W(100). PMID- 9939337 TI - X-ray-photoelectron-spectroscopy study of the electronic structure of Ni-P metallic glasses. PMID- 9939339 TI - Structures of small alkali-metal clusters. PMID- 9939338 TI - Energy-level statistics of metallic fine particles: Analytical approach. PMID- 9939340 TI - Diffusion and chemical activity of Zr-Sn and Zr-Ti systems. PMID- 9939342 TI - Expansion-variational studies of hydrogenlike systems in arbitrary magnetic fields. PMID- 9939341 TI - Thermal relaxation of adsorbed atoms in an intense laser field. PMID- 9939343 TI - Titanium Knight shift in titanium hydride. PMID- 9939344 TI - Characterization and decoration of the two-dimensional Penrose lattice. PMID- 9939345 TI - Generalized Kadanoff-Baym ansatz for deriving quantum transport equations. PMID- 9939346 TI - Interband Faraday rotation in diluted magnetic semiconductors: Zn1-xMnx PMID- 9939347 TI - Plasmon and magnetoplasmon excitation in two-dimensional electron space-charge layers on GaAs. PMID- 9939348 TI - Picosecond-laser-induced transient dynamics of phonons in GaP and ZnSe. PMID- 9939349 TI - Electronic-transport behavior in single-crystalline Ba0.03Sr0.97TiO3. PMID- 9939350 TI - Free-exciton diffusion and decay in zero-stress Ge. PMID- 9939352 TI - Far-infrared spectra of bis-(tetramethyltetraselenafulvalene) hexafluoroarsenate PMID- 9939351 TI - Molecular-dynamics simulation of amorphous germanium. PMID- 9939353 TI - Quantum theory of thermal noises for steady-state hot-electron transport under a strong electric field. PMID- 9939354 TI - Optical dispersion relations for amorphous semiconductors and amorphous dielectrics. PMID- 9939355 TI - Uniaxial stress dependence of spatially confined excitons. PMID- 9939356 TI - rf-sputtered B-doped a-Si:H and a-Si-B-H alloys. PMID- 9939357 TI - Photogenerated high-density electron-hole plasma energy relaxation and experimental evidence for rapid expansion of the electron-hole plasma in CdSe. PMID- 9939358 TI - Solution of a new nonlinear equation for the distribution of charge carriers in a semiconductor. PMID- 9939359 TI - Si/InP(110) heterojunction. PMID- 9939360 TI - Spin-1 quasiparticle and spin polarization of the ground state in the fractional quantum Hall effect. PMID- 9939361 TI - Calculated electron densities and sp3-bonding character for binary and ternary Zintl phases. PMID- 9939363 TI - Dynamics of coherent optical phonon generation and decay in GaP. PMID- 9939364 TI - Effective dielectric and photoelastic tensors of superlattices in the long wavelength regime. PMID- 9939362 TI - Au-GaAs(110) interface: Photoemission studies of the effects of temperature. PMID- 9939366 TI - Ground-state energy of charged quantum fluids in two dimensions. PMID- 9939365 TI - Leakage-induced and disorder-activated modes from the folded acoustic branches in GaAs-AlAs superlattices. PMID- 9939367 TI - Electron-electron scattering and mobilities in semiconductors and quantum wells. PMID- 9939368 TI - Impurity levels induced by a C impurity in GaAs. PMID- 9939369 TI - Real-space force constants for lattice dynamics in silicon and germanium in the adiabatic bond-charge model. PMID- 9939370 TI - Self-consistent theory of electronic states and dielectric response in semiconductors. PMID- 9939371 TI - Electrical conductivity and thermoelectric power of highly graphitizable poly(p phenylene vinylene) films. PMID- 9939373 TI - Self-consistent one-electron states of substitutional and interstitial 5d transition-atom impurities in silicon. PMID- 9939372 TI - Dynamic Stark effect in interacting electron-hole systems: Light-enhanced excitons. PMID- 9939374 TI - Hydrogen adsorption on Ge(100) studied by high-resolution energy-loss spectroscopy. PMID- 9939375 TI - Identification of a defect in a semiconductor: EL2 in GaAs. PMID- 9939376 TI - Nonempirical cluster-model study of the chemisorption of atomic hydrogen on the (111) surface of diamondlike crystals. PMID- 9939377 TI - Combined photoacoustic and photoconductive spectroscopic investigation of nonradiative recombination and electronic transport phenomena in crystalline n type CdS. I. Experiment. PMID- 9939378 TI - Combined photoacoustic and photoconductive spectroscopic investigation of nonradiative recombination and electronic transport phenomena in crystalline n type CdS. II. Theory. PMID- 9939379 TI - Cyclotron and spin resonance in electron inversion layers on InSb. PMID- 9939380 TI - Magneto-optical absorption of polarons. PMID- 9939381 TI - ESR in layer-substrate structures: The line shape and nondestructive contactless measurements of the layer conductivity. PMID- 9939382 TI - Linewidth study of the dye molecule quinizarin in solid alcohol glasses. PMID- 9939383 TI - Transient small-polaron hopping motion. PMID- 9939384 TI - Spin memory in the 2A-bar-->E-bar relaxation in ruby. PMID- 9939385 TI - Electronic structure of the CaF2/Si(111) interface. PMID- 9939386 TI - Observation of persistent ir hole burning in the vibrational spectrum of CN- in KBr. PMID- 9939388 TI - Calculation of the mobility of electrons injected in liquid methane. PMID- 9939387 TI - Photoemission satellites and electronic structure of Fe2O3. PMID- 9939389 TI - Domain-wall modes for krypton monolayers on graphite. PMID- 9939390 TI - Lithium-insertion reactions in LixMo6Se8-yIy structural studies and the absence of triclinic distortions. PMID- 9939391 TI - Delocalized versus localized unoccupied 5f states and the uranium site structure in uranium oxides and glasses probed by x-ray-absorption near-edge structure. PMID- 9939392 TI - Satellite-intensity patterns from the charge-density wave in potassium. PMID- 9939394 TI - Quantum energy spectra and one-dimensional quasiperiodic systems. PMID- 9939395 TI - Transport and magnetic properties of icosahedral and glassy Pd-U-Si alloys. PMID- 9939393 TI - Relaxation-time effects in the transverse dielectric function and the electromagnetic properties of metallic surfaces and small particles. PMID- 9939396 TI - Neutron diffraction study of ScD1.8. PMID- 9939397 TI - Consequences of crystallographic equivalence between bct and fct indium. PMID- 9939398 TI - Plasmon band structure in a lateral multiwire semiconductor superlattice. PMID- 9939400 TI - Quenching of band-edge photoluminescence in InP by Cu. PMID- 9939399 TI - Hole subbands in semiconductor thin layers. PMID- 9939401 TI - Reduced symmetry and the band structure of semiconductor alloys. PMID- 9939402 TI - Two-dimensional magnetic polaron in the quantum well of dilute magnetic semiconductors. PMID- 9939403 TI - Low-temperature thermal conductivity of sodium borate glasses. PMID- 9939404 TI - Point-defect contribution to the low-frequency dielectric response of LiTaO3: Reanalysis. PMID- 9939405 TI - Crossover phenomenon in surface segregation of Cu-Ni alloys. PMID- 9939406 TI - Comment on "g-factor anisotropy of conduction electrons in InSb" PMID- 9939407 TI - Comment on "Effective-mass superlattice" PMID- 9939408 TI - Erratum: Voltage-dependent scanning-tunneling microscopy of a crystal surface: Graphite PMID- 9939410 TI - Orientation of small rafts of xenon atoms physisorbed on Pt(111): A molecular dynamics study. PMID- 9939409 TI - Orientational ordering induced by shear deformation in an amorphous Lennard-Jones solid. PMID- 9939412 TI - Delocalized quantum nature of hydrogen adsorbed on the Rh(111) crystal surface. PMID- 9939411 TI - Mg32(Zn,Al)49-type icosahedral quasicrystals formed by solid-state reaction and rapid solidification. PMID- 9939413 TI - Analysis of core-level shifts in some metallic Ni compounds. PMID- 9939415 TI - Electron-phonon backscattering and phonon dynamics in one-dimensional metals. PMID- 9939414 TI - Photoemission study of Ag monolayer systems: Effects of the substrate. PMID- 9939416 TI - Nature of the eigenstates on a Fibonacci chain. PMID- 9939418 TI - Low-temperature structures of xenon monolayers adsorbed on graphite. PMID- 9939417 TI - Photoluminescence study of a dilute two-dimensional electron gas in GaAs-AlxGa1 xAs quantum wells. PMID- 9939419 TI - Doubly resonant LO-phonon Raman scattering via the deformation potential with a single quantum well. PMID- 9939420 TI - Surface bands for single-domain 2 x 1 reconstructed Si(100) and Si(100): As. Photoemission results for off-axis crystals. PMID- 9939421 TI - Metastable impurities in semiconductors: Si:Mg and Si:Be. PMID- 9939422 TI - Interstitial chemisorption and interface formation of Pt on Si(111) observed by surface extended x-ray-absorption fine-structure and L2,3-edge x-ray-absorption resonance spectroscopies. PMID- 9939423 TI - Landau-level population inversion in crossed electric and quantizing magnetic fields. PMID- 9939424 TI - Cyclotron-resonance oscillations in InAs quantum wells. PMID- 9939425 TI - Surface Brillouin scattering in black phosphorus. PMID- 9939426 TI - CaF2/Si(111): Thin-film characterization by high-resolution electron-energy-loss spectroscopy. PMID- 9939428 TI - Defect structure of the solid solutions Ba1-xGdxF2+x. PMID- 9939427 TI - Low-temperature nuclear-spin relaxation times and line shapes for Hsub2 in solid nonmagnetic hosts. PMID- 9939429 TI - Observation of surface-initiated melting. PMID- 9939431 TI - Fundamental radiation-induced defect centers in synthetic fused silicas: Atomic chlorine, delocalized E' centers, and a triplet state. PMID- 9939430 TI - Analysis of the lowest 4f-->5d two-photon transition in Ce3+:CaF2. PMID- 9939432 TI - Interaction of rare-gas-halide excimers with simple cryogenic liquids. PMID- 9939434 TI - Electronic diffusion coefficient for fast-ion dechanneling. PMID- 9939433 TI - Many-state relaxation model for the Mossbauer spectra of superparamagnets. PMID- 9939435 TI - Optical study of hyperfine coupling in the 7F0 and 5D0 states of two Eu3+ centers in CaF2 and CdF2. PMID- 9939436 TI - Rayleigh scattering and weak localization: Effects of polarization. PMID- 9939437 TI - Magnetic relaxation in Fe-(SiO2) granular films. PMID- 9939438 TI - Fluorescence quenching in KNdxGd1-xP4O12 crystals studied using an isolated ion pair interaction. PMID- 9939439 TI - Josephson current in low-dimensional proximity systems and the field effect. PMID- 9939440 TI - Exchange and correlation contributions to superconducting electron pairing. PMID- 9939441 TI - Unusual temperature dependence of the upper critical field in superconducting heavy-fermion systems. PMID- 9939442 TI - Gapless superfluidity in 3He films. PMID- 9939443 TI - Pulse propagation in a resonant medium: Application to sound waves in superfluid 3He-B. PMID- 9939444 TI - Relaxation behavior in a tiling model for glasses. PMID- 9939446 TI - Crystal and electronic structure of metallic lithium at low temperatures. PMID- 9939445 TI - Helium in Vycor, constrained randomness, and the Harris criterion. PMID- 9939447 TI - Relaxation and recombination in spin-polarized atomic hydrogen. PMID- 9939448 TI - X-ray-edge studies and photoemission of MnxSn1-xMo6S8. PMID- 9939449 TI - Landau model for superfluid films and interfaces at T=0: Local interactions. PMID- 9939450 TI - Possible superconductivity in nearly antiferromagnetic itinerant fermion systems. PMID- 9939452 TI - Thermal conductivity of bis-tetramethyltetraselenafulvalene perchlorate PMID- 9939451 TI - Tunneling of H and D trapped by O(N) in niobium by anelastic relaxation measurements. PMID- 9939453 TI - Magnetism and spin fluctuation effects in heavy-fermion CeRu2Si2 induced by partial substitution of Ru and Si. PMID- 9939454 TI - Effective interactions for self-energy. I. Theory. PMID- 9939455 TI - Effective interactions for self-energy. II. Application to electron and electron hole liquids. PMID- 9939456 TI - Nonequilibrium model of the superconducting tunneling junction x-ray detector. PMID- 9939457 TI - Nonlinear quantum and classical renormalization-group trajectories for the interacting Bose fluid. PMID- 9939458 TI - Phenomenology and origin of growth oscillations: A simple stochastic model. PMID- 9939459 TI - Real-space renormalization-group investigation of the three-dimensional semi infinite Blume-Emery-Griffiths model. PMID- 9939460 TI - Spin-polarized photoemission from iron by pulsed laser radiation. PMID- 9939461 TI - Ferromagnetic resonance in a system composed of a ferromagnetic substrate and an exchange-coupled thin ferromagnetic overlayer. PMID- 9939462 TI - Diffusion noise of fractal networks and percolation clusters. PMID- 9939464 TI - Conductivity fluctuations and the amplitude of the long-time tail. PMID- 9939463 TI - Images, Landau expansions, and symmetry changes. PMID- 9939465 TI - High-resolution adsorption isotherm measurement of adsorbed krypton near the commensurate-incommensurate transition. PMID- 9939466 TI - Domain-growth kinetics in the two-dimensional three-state chiral clock model. PMID- 9939467 TI - Effects of a magnetic field on the thermodynamics of dilute classical spin chains. PMID- 9939469 TI - Classical limit of sine-Gordon thermodynamics using the Bethe ansatz. PMID- 9939468 TI - Corrections to late-stage behavior in spinodal decomposition: Lifshitz-Slyozov scaling and Monte Carlo simulations. PMID- 9939470 TI - Role of single-ion anisotropy in amorphous ferrimagnetic alloys. PMID- 9939472 TI - EPR linewidth (T >~ Tg) in amorphous transition-metal-metalloid spin glasses: Theory. PMID- 9939471 TI - Crystal optical studies of precursor and spontaneous polarization in PbTiO3. PMID- 9939473 TI - Two coupled semi-infinite systems near criticality. PMID- 9939474 TI - Vectorized coding for Monte Carlo simulation of the one-dimensional quantum spin system. PMID- 9939475 TI - Extension of the Lifshitz-point concept to first-order phase transitions: Incommensurate NaNO2 in a transverse electric field. PMID- 9939476 TI - New algorithm for the numerical simulation of fermions. PMID- 9939477 TI - Magnetic properties of praseodymium iron garnet and neodymium iron garnet. PMID- 9939479 TI - Pair approximation to describe magnetic properties of disordered spin systems. PMID- 9939478 TI - Hugoniot overtake sound-velocity measurements on CsI. PMID- 9939480 TI - Numerical study of the growth kinetics for a Langevin equation. PMID- 9939481 TI - Magnetic susceptibility of MnCl2- and CoCl2-graphite intercalation compounds. PMID- 9939482 TI - Temperature dependence of the intrinsic remanent magnetization and anisotropy energy in the spin glass Cu-Mn. PMID- 9939483 TI - Concentration dependence of the spin-glass temperature of metallic alloys. PMID- 9939484 TI - Crystal-field effect on the transverse susceptibility in spin-S Ising chains. PMID- 9939485 TI - Ising model on the Bethe lattice with competing interactions up to the third nearest-neighbor generation. PMID- 9939486 TI - Dynamics of discommensuration patterns. PMID- 9939487 TI - Formation of domains in the random-field Ising model. PMID- 9939488 TI - Quantum-mechanical states of dipolar crystals with two magnetic ions per unit cell. PMID- 9939489 TI - Quantum-mechanical ground state of dysprosium trichloride hexahydrate. PMID- 9939490 TI - Influence of third-nearest-neighbor interactions on the ground state of Heisenberg linear chains. PMID- 9939491 TI - Vibronic theory of a structural phase transition and a tricritical point in IV-VI compounds. PMID- 9939492 TI - Modified boundary conditions and finite-size scaling for the one-dimensional spin (1/2) dimerized XY model. PMID- 9939494 TI - Magnetic excitations in spin-density-wave systems. PMID- 9939493 TI - Phase diagram and phase transitions of monolayer and bilayer CF4 on graphite. PMID- 9939495 TI - Distribution of fractal clusters and scaling in the Ising model. PMID- 9939496 TI - Tracer correlation factor in a square-lattice gas with extended hard-core interactions. PMID- 9939497 TI - High-pressure and high-temperature electrical resistivity of ferromagnetic transition metals: Nickel and iron. PMID- 9939498 TI - Noise exponent in superconducting-normal metal mixtures. PMID- 9939499 TI - Growth anisotropy in the Nd-Y and Pr-Y iron garnets. PMID- 9939500 TI - Itinerant f-electron model of heavy-fermion systems. PMID- 9939501 TI - Comparison of dynamic and static scaling exponents for the Mn2Al2Si3O12 spin glass. PMID- 9939503 TI - Adsorption binding-energy variation resulting from substrate size effects. PMID- 9939502 TI - Extended and localized states in the periodic Anderson model. PMID- 9939504 TI - Bifurcation response in a KH2PO4 crystal near the ferroelectric transition. PMID- 9939505 TI - Finite-lattice extrapolations for the ground-state energies of antiferromagnetic Heisenberg rings. PMID- 9939506 TI - Diffusion in random structures with a topological bias. PMID- 9939507 TI - Microcanonical simulation of the three-dimensional random-field Ising model. PMID- 9939508 TI - Vibrational spectroscopic study of ferroelectric SbNbO4, antiferroelectric BiNbO4, and their solid solutions. PMID- 9939509 TI - Estimate of a universal critical-amplitude ratio from its epsilon expansion up to epsilon 2. PMID- 9939510 TI - Clarification of soliton diffusion in the phi4 theory. PMID- 9939512 TI - Reply to "Comment on 'Tunneling alpha 2F( omega ) from sputtered thin-film NbN.' " PMID- 9939511 TI - Comment on "Tunneling alpha 2F( omega ) from sputtered thin-film NbN." PMID- 9939513 TI - Erratum: Theory of coupled phason and sound-wave normal modes in the incommensurate phase of quartz PMID- 9939515 TI - Brillouin scattering studies of LaF3 at high temperatures. PMID- 9939514 TI - Energy spectra of secondary electrons from Al induced by heavy-ion impact. PMID- 9939516 TI - Spin-orbit scattering measurements from localization and superconducting tunneling. PMID- 9939517 TI - Fisher renormalization of the critical behavior in the random-field problem. PMID- 9939518 TI - Relaxation behavior of fractal-cluster spin glasses. PMID- 9939519 TI - Thermal expansion and specific heat of monocrystalline URu2Si2. PMID- 9939520 TI - Magnetization of the Coqblin-Schrieffer model in the large-N limit at nonzero field. PMID- 9939521 TI - Lattice and continuum percolation transport exponents: Experiments in two dimensions. PMID- 9939522 TI - Quantitative prediction of permeability in porous rock. PMID- 9939523 TI - Magnetic structure of erbium. PMID- 9939525 TI - d -wave pairing near a spin-density-wave instability. PMID- 9939524 TI - Ground-state structure of the one-dimensional Heisenberg antiferromagnet. PMID- 9939526 TI - Geometrical phase transitions on hierarchical lattices and universality. PMID- 9939527 TI - Dehybridization of the 4f shell in Si-substituted CeRh3B2. PMID- 9939529 TI - Discommensurations in icosahedral phases. PMID- 9939528 TI - Universal Poisson's ratio in a two-dimensional random network of rigid and nonrigid bonds. PMID- 9939531 TI - Sm M4,5 emission spectra of Sm metal and SmB6 with fluorescence-excitation and near-threshold electron-excitation methods. PMID- 9939530 TI - Iron on palladium (111) studied with photoemission, low-energy electron diffraction, and Auger-electron spectroscopy. PMID- 9939532 TI - Valence-electronic structure of potassium adsorbed on Cu(001) deduced from work function change and electron-energy-loss spectroscopy. PMID- 9939533 TI - Dimensionality and size effects in simple metals. PMID- 9939534 TI - Effects of spatial dispersion and damping on exciton absorption. PMID- 9939535 TI - Plasmon linewidth in metals and semiconductors: A memory-function approach. PMID- 9939536 TI - Local atomic environments in periodic and aperiodic Al-Mn alloys. PMID- 9939537 TI - Surface-polariton solitons. PMID- 9939538 TI - Electron transport in calcium-based metallic glasses. PMID- 9939540 TI - Microscopic stress tensors in quantum systems. PMID- 9939539 TI - Electron transport in La100-xAlx metallic glasses. PMID- 9939542 TI - Multiple-scattering treatment of surfaces and interfaces. PMID- 9939541 TI - Microscopic stress tensors in atoms. PMID- 9939543 TI - Electron-energy-loss studies of surface vibrations on Ni(100): Surface and bulk phonon contributions. PMID- 9939544 TI - Electron transmission in a one-dimensional quasicrystal. PMID- 9939545 TI - Theory of hopping conduction by the path-probability method. PMID- 9939546 TI - Effect of the surface condition on the deviation from Matthiessen's rule in thin copper samples. PMID- 9939547 TI - X-ray resonant Raman cross section and yield in nickel. PMID- 9939548 TI - Electronic theory of the chemical short-range order in liquid and amorphous transition-metal alloys. PMID- 9939549 TI - Lattice dynamics of LaB6 studied by ion channeling: La in the Einstein model. PMID- 9939550 TI - Electronic structure of the Fe/Ge(110) interface. PMID- 9939552 TI - Accelerating the convergence of self-consistent linearized augmented-plane-wave calculations. PMID- 9939551 TI - Surface segregation of Ni-Cu binary alloys studied by an atom-probe. PMID- 9939553 TI - Investigation of the electronic structure and phonon anharmonicity in beta - and gamma -NbH. PMID- 9939554 TI - Lattice dynamics of lithium at low temperature. PMID- 9939555 TI - Spectroscopy of the O-H and O-D stretching vibrations in SrTiO3 under applied electric field and uniaxial stress. PMID- 9939556 TI - Splitting of valence levels in Ag-Au alloys. PMID- 9939558 TI - Metal-insulator transition and effects of localization and correlation in amorphous FexSb100-x alloys. PMID- 9939557 TI - Linear augmented-Slater-type-orbital method for electronic-structure calculations. IV. 5d-5d alloys. PMID- 9939560 TI - Nonradiative lifetime of excited states near a small metal particle. PMID- 9939559 TI - Hybridization of electronic bands along the <110> axis in platinum observed by spin-polarized, momentum-resolved photoemission. PMID- 9939561 TI - Theoretical model for the Raman scattering by localized and magnon modes in mixed transition-metal fluorides. PMID- 9939562 TI - Effect of ion implantation on the electronic structure of bismuth. PMID- 9939563 TI - Collective excitations in metallic glasses: A model of dynamic structure. PMID- 9939565 TI - Interatomic interactions in solids: An effective-medium approach. PMID- 9939564 TI - Linewidths from sum rules in mixed crystals. PMID- 9939566 TI - Charge-density-wave conduction: Dynamics and finite-size effects. PMID- 9939568 TI - New layer method for the investigation of the electronic properties of two dimensional periodic spatial structures: First applications to copper and aluminum. PMID- 9939567 TI - Magnetoresistivity of the spin-fluctuation materials TiBe2 and UAl2. PMID- 9939569 TI - Novel method for studying large-scale coalescence. PMID- 9939570 TI - Correlated random walk on a bcc lattice with next-nearest-neighbor hops: Self consistent decoupling approximation. PMID- 9939571 TI - Mn(IV) and Cr(III) impurities in cubic BaTiO3: Theoretical study through a molecular-orbital model. PMID- 9939572 TI - Localization and phase coherence length in the Lloyd model. PMID- 9939573 TI - Polarization of hot-electron photoluminescence in GaAs-type semiconductors for recombination on a shallow acceptor. PMID- 9939575 TI - Nonequilibrium electron-phonon scattering in semiconductor heterojunctions. PMID- 9939574 TI - Electrical breakdown at semiconductor grain boundaries. PMID- 9939577 TI - Electron-hole exchange interaction for donor-acceptor pairs in CdS determined as a function of separation distance by optically detected magnetic resonance. PMID- 9939576 TI - First-principles study of the structural properties of Ge. PMID- 9939578 TI - Some consequences of the closure of the momentum Bloch functions. PMID- 9939579 TI - Band theory of superlattices. PMID- 9939580 TI - Pendellosung intensity-beat measurements with 0.0392- and 0.0265-A PMID- 9939582 TI - Low-temperature ac conductivity of semiconducting NbO2. PMID- 9939581 TI - Far-infrared absorption by shallow donors in multiple-well GaAs-Ga1-xAlxAs heterostructures. PMID- 9939583 TI - Hot-electron luminescence in AlSb. PMID- 9939584 TI - Optical properties and excitation-induced distortions of a trigonal Cu-related neutral complex with a bound exciton at 2.26 eV in ZnTe. PMID- 9939585 TI - Excess low-temperature specific heat in a model glass. PMID- 9939587 TI - Energy spectra of donors and acceptors in quantum-well structures: Effect of spatially dependent screening. PMID- 9939586 TI - Tunneling-assisted photon emission from quantum wells. PMID- 9939588 TI - Electronic structure of amorphous III-V and II-VI compound semiconductors and their defects. PMID- 9939590 TI - Persistent photocurrent in amorphous chalcogenides. PMID- 9939589 TI - Polarized hot-electron photoluminescence in highly doped GaAs. PMID- 9939591 TI - Kinetic study of the 830- and 889-cm-1 infrared bands during annealing of irradiated silicon. PMID- 9939592 TI - Crystalline As2Se3: Optical properties. PMID- 9939593 TI - Optical characterization and thermal dissociation of bound excitons in CdSexTe1 x. PMID- 9939595 TI - Picosecond band filling in highly excited In-Ga-As-P films. PMID- 9939594 TI - Photoluminescence in ultrathin a-Si:H layers. PMID- 9939597 TI - Empirical tight-binding calculation of dispersion in the linear optical properties of tetrahedral solids. PMID- 9939596 TI - Dynamical conductivity of soliton lattice and polaron lattice in the continuum model of polyacetylene. PMID- 9939598 TI - Hopping conduction in a two-dimensional impurity band. PMID- 9939600 TI - Low-lying excited states of a hydrogenic donor and resonant states in a quantum well. PMID- 9939599 TI - Bismuth-doped amorphous germanium sulfide semiconductors. PMID- 9939602 TI - Energy transfer among Yb3+ ions in a silicate glass. PMID- 9939601 TI - Theory of the cyclotron resonance spectrum of a polaron in two dimensions. PMID- 9939603 TI - Nonresonant energy transfer in a system with two different rare-earth sites: beta '-Gd2(MoO4)3:Eu3+ and beta 'Eu2(MoO4)3. PMID- 9939605 TI - Low-temperature properties of crystalline (KBr)1-x(KCN)x: A model glass. PMID- 9939604 TI - Transport and relaxation of hot conduction electrons in an organic dielectric. PMID- 9939607 TI - Energy up-conversion in the visible to ultraviolet range in LaF3:(Pr3+,Nd3+). PMID- 9939606 TI - Heat capacity of CH4 on graphite and the quantum cell model. PMID- 9939608 TI - Aftereffect investigations in mixed-valence indium chlorides. PMID- 9939610 TI - Volume expansion of diamond during ion implantation. PMID- 9939609 TI - Ordering of hydrogen overlayers on the (110) surfaces of nickel and palladium. PMID- 9939611 TI - Defect-induced hyper-Raman spectra in cubic zirconia. PMID- 9939612 TI - Two-photon-absorption cross section of Nd3+ in yttrium aluminum garnet and yttrium lithium fluoride near 1.06 microm. PMID- 9939613 TI - Nonlinear phonon generation via localized modes. PMID- 9939614 TI - Energy transfer by phonons undergoing resonance-elastic and inelastic scattering in an infinite medium. PMID- 9939615 TI - Analysis of the r dependence of self-consistent exchange parameters alpha i of different shells in neon, argon, and krypton. PMID- 9939616 TI - Phonons in the mixed crystal CdCl2(1-x)Br2x: n-mode behavior (n >= 10). PMID- 9939617 TI - Structure factor of a single linear chain of finite size. PMID- 9939618 TI - Solid solutions of alkali halide compounds: A new model. PMID- 9939620 TI - Nature of the electronic spectrum in positionally disordered systems with weak electron-ion potential. PMID- 9939619 TI - Anomalous transmission of x rays through a quasicrystal. PMID- 9939621 TI - New approach to minimal basis set with localized orbitals. II. Improvement of the single-site approximation. PMID- 9939622 TI - Electronic structure and properties of transition-metal-metalloid glasses: Ni1 xPx. PMID- 9939623 TI - Optical properties of orientationally disordered systems. PMID- 9939625 TI - Hall factor of doped n-type GaAs and n-type InP. PMID- 9939624 TI - Frequency modulation of the narrow-band noise in sliding charge-density-wave conductors. PMID- 9939627 TI - Type-II superlattice: Inversion of the dielectric function. PMID- 9939626 TI - Raman scattering from ultraheavily-ion-implanted and laser-annealed silicon. PMID- 9939628 TI - Barrier-width dependence of optical transitions involving unconfined energy states in GaAs-AlxGa1-xAs superlattices. PMID- 9939629 TI - Anisotropic electrical conductivity of the solid electrolyte Rb4Cu9Cl13. PMID- 9939630 TI - Field-enhanced electronic transport in solids. PMID- 9939631 TI - Comment on "Photoemission study of the existence of a valence-band satellite in Fe" PMID- 9939633 TI - Erratum: Coherence in singlet-exciton motion in anthracene crystals PMID- 9939632 TI - Reply to "Comment on 'Photoemission study of the existence of a valence-band satellite in Fe' " PMID- 9939634 TI - Erratum: Correlation effects on the oscillator strength of optical absorption: Sum rule for the one-dimensional Hubbard model PMID- 9939635 TI - Neutron scattering study of the vibrational density of states in icosahedral and crystalline Al0.80Mn0.20. PMID- 9939636 TI - Annealing behavior of hydrogen traps in Ne-implanted Ta. PMID- 9939637 TI - Resonance trapping of nonthermal positrons. PMID- 9939639 TI - Direct evidence of three-center-Auger recombination processes in ZnS:Cu,Fe. PMID- 9939638 TI - Unoccupied surface states on W(001) and Mo(001) by inverse photoemission. PMID- 9939640 TI - Electric field gradients of randomly disordered compounds. PMID- 9939641 TI - Collective spin waves in Fe-Pd and Fe-W multilayer structures. PMID- 9939642 TI - Localized phonon modes in Fe-Pd multilayer structures. PMID- 9939644 TI - Relation between the conductivity, the ultrasonic attenuation, and nonlinear sigma -model composite operators at the Anderson transition. PMID- 9939643 TI - Critical behavior of transverse sound attenuation at a mobility edge. PMID- 9939645 TI - Contamination-mediated deformation of graphite by the scanning tunneling microscope. PMID- 9939646 TI - Dynamics of photoexcited carriers sinking into an enlarged well in a GaAs/AlAs short-period superlattice. PMID- 9939647 TI - Spectroscopy of excited states in In0.53Ga0.47 As-InP single quantum wells grown by chemical-beam epitaxy. PMID- 9939648 TI - Optical dephasing of homogeneously broadened two-dimensional exciton transitions in GaAs quantum wells. PMID- 9939650 TI - Exact calculations of quasibound states of an isolated quantum well with uniform electric field: Quantum-well Stark resonance. PMID- 9939649 TI - Ambipolar drift-length measurement in amorphous hydrogenated silicon using the steady-state photocarrier grating technique. PMID- 9939651 TI - Origin of the dielectric relaxation frequency in sliding-charge-density-wave systems. PMID- 9939652 TI - Self-interaction correction to the local-density approximation in the calculation of the energy band gaps of semiconductors based on the full-potential, linearized, augmented-plane-wave method. PMID- 9939653 TI - Surface optical phonons in LiF(001) observed by inelastic helium scattering. PMID- 9939654 TI - Nonlinear Hall effect in K0.3MoO3 due to the sliding of charge-density waves. PMID- 9939656 TI - "Channel decomposition" of superexchange interactions in the valence-bond method. PMID- 9939655 TI - Resistivity minima in Ausub1-xNix alloys (0.30 <= x <= 0.42). PMID- 9939657 TI - Metastability of the Si(111)/Cu interface: A spatially resolved Auger line-shape spectroscopy investigation. PMID- 9939658 TI - Theory of electronic excitations in coated metal particles: Jellium-on-jellium model. PMID- 9939659 TI - Dielectric response of a semi-infinite electron gas: Independent-particle dynamic response function. PMID- 9939660 TI - Resistivities and mean free paths in individual layers of a metallic multilayered structure. PMID- 9939661 TI - Calculation of corrections to Fresnel optics from density response. PMID- 9939662 TI - Soft-x-ray photoemission study of Co-n-type InP(110) interface. PMID- 9939663 TI - Quasiperiodic lattice: Electronic properties, phonon properties, and diffusion. PMID- 9939664 TI - Resistivity of Ca-Al metallic glasses. PMID- 9939665 TI - Solubility of H, D, and T in Pd at low concentrations. PMID- 9939666 TI - Escape problem for particles with internal degrees of freedom out of a potential. PMID- 9939667 TI - Quasicrystals. I. Definition and structure. PMID- 9939668 TI - Quasicrystals. II. Unit-cell configurations. PMID- 9939669 TI - Self-consistent molecular-cluster calculations of the electric field gradient of 5sp impurities (47Ag- 54Xe) in cadmium. PMID- 9939670 TI - Electronic and structural properties of Lu under pressure: Relation to structural phases of the rare-earth metals. PMID- 9939671 TI - Ensemble and temperature averaging of quantum oscillations in normal-metal rings. PMID- 9939672 TI - Binding-energy shifts from alloying at metal-compound-semiconductor interfaces. PMID- 9939673 TI - Transition from bandlike to quasiatomic behavior in the N6,7O4,5O4,5 Auger spectra of iridium, platinum, and gold. PMID- 9939674 TI - Quantum-mechanical-model calculations of radiative properties of a molecular crystal. II. A transition to coherence in the spontaneous emission from disordered two-dimensional excitons. PMID- 9939676 TI - Surface-reconstruction-induced changes in free-carrier scattering from the W(100) surface: An infrared surface-electromagnetic-wave study. PMID- 9939675 TI - Fourth-order gradient expansion of the fermion kinetic energy: Extra terms for nonanalytic densities. PMID- 9939677 TI - Magnetic susceptibility of alpha and beta phases of di PMID- 9939678 TI - Relativistic spin-polarized electronic structure of Ce and Pu. PMID- 9939679 TI - Temperature dependence of noise processes in metals. PMID- 9939680 TI - Elastic jellium sphere in a static electric field. PMID- 9939681 TI - Energy-level statistics of metallic fine particles: Computer simulations. PMID- 9939682 TI - Baber scattering in strong magnetic fields: The effect of Landau quantization. PMID- 9939683 TI - Icosahedral order in glass: Acoustic properties. PMID- 9939684 TI - Empty surface states, image states, and band edge on Au(111). PMID- 9939686 TI - Volume versus surface origin of 1/f noise in metals. PMID- 9939685 TI - Structural and electronic properties of the Al-GaAs(110) interface. PMID- 9939687 TI - Theory of angle-resolved photoemission extended fine structure. PMID- 9939689 TI - Sphere packings and local environments in Penrose tilings. PMID- 9939688 TI - Atom diffraction from soft periodic scattering potentials: Calculation of diffraction intensities by an extended GR method. PMID- 9939690 TI - Kinetics of hydrogen absorption by Pd(110). PMID- 9939692 TI - Electronic damping of adsorbate motion: CO vibration on the Cu(100) surface. PMID- 9939691 TI - Dislocation studies on deformed single crystals of high-purity iron using positron annihilation: Determination of dislocation densities. PMID- 9939693 TI - Effect of surface scattering on optical properties of metallic double-layer films. PMID- 9939694 TI - Two-photon momentum density and angular correlation of positron annihilation radiation in Pd and PdH. PMID- 9939695 TI - Transferable nonorthogonal tight-binding parameters for silicon. PMID- 9939696 TI - Effect of high magnetic fields on the electronic structure of density-wave systems. PMID- 9939697 TI - Model of electronic states at the Si-SiO2 interface. PMID- 9939698 TI - Effects of electron-electron correlations on defect and interface states in amorphous Si and SiO2 systems. PMID- 9939699 TI - X-ray-emission-spectroscopy study of vacancy-induced electronic states in substoichiometric TiNx. PMID- 9939700 TI - Magneto-optical determination of the HgTe-CdTe superlattice band structure. PMID- 9939701 TI - Simulated annealing of silicon atom clusters in Langevin molecular dynamics. PMID- 9939702 TI - Localized surface optical phonons in a layered crystal: GaSe(001). PMID- 9939703 TI - High-temperature nucleation and silicide formation at the Co/Si(111)-7 x 7 interface: A structural investigation. PMID- 9939704 TI - Quantum oscillations in the magnetotransport of a finite two-dimensional Anderson model. PMID- 9939705 TI - Theory of alloy broadening of deep levels in semiconductor alloys: Nitrogen in AlxGa1-xAs. PMID- 9939706 TI - Rayleigh-Taylor instability in phonon-wind-driven electron-hole plasma. PMID- 9939707 TI - Optical-absorption spectrum of polyacetylene: Effect of lattice deformation, impurities, and end conditions. PMID- 9939708 TI - Far-infrared absorption profiles for shallow donors in GaAs-AlxGa1-xAs quantum well structures. PMID- 9939710 TI - Multiphoton absorption of intense electromagnetic laser radiation in narrow-gap semiconductors. PMID- 9939709 TI - Valence-band-structure determination of InSb by angle-resolved photoemission. PMID- 9939711 TI - Photoemission investigation of silicon chemisorbed on aluminum. PMID- 9939712 TI - Shallow donors in semi-insulating GaAs and their role in the excitation of the 0.64-eV photoluminescence. PMID- 9939713 TI - Dielectric function and plasmon structure of stage-1 intercalated graphite. PMID- 9939714 TI - Charge-density waves studied with the use of a scanning tunneling microscope. PMID- 9939716 TI - Spatial expansion of electron-hole plasma in Si. PMID- 9939715 TI - Effect of neutral donor scattering on the time-dependent exciton-polariton photoluminescence line shape in GaAs. PMID- 9939717 TI - Statistics of the fractionally charged excitations in the quantum Hall effect. PMID- 9939718 TI - Dimer-chain model for the 7 x 7 and the 2 x 8 reconstructed surfaces of reconstructed surfaces of Si(111) and Ge(111). PMID- 9939719 TI - Theory of the impurity-doping effect on electronic states in a quantum well of arbitrary depth of a semiconductor. PMID- 9939720 TI - Light scattering from a layered electron gas. PMID- 9939721 TI - Influence of dissipation on the accuracy of the integral quantum Hall effect. PMID- 9939722 TI - Efficient approach to the ab initio Hartree-Fock problem of solids, with application to diamond and silicon. PMID- 9939723 TI - Electronic and structural properties of BN and BP. PMID- 9939725 TI - Stacking fault and four-body interaction in the Si(111)7 x 7 structure. PMID- 9939724 TI - Excitons in semimagnetic semiconductor quantum-well systems: Magnetic polaron effects. PMID- 9939726 TI - Continuum model for vibrational excitations of conjugated polymers. PMID- 9939728 TI - Effect of electric fields on the propagation of ultrasonic pulses in o-TaS3. PMID- 9939727 TI - Electronic structure of pyrrole-based conducting polymers: An electron-energy loss-spectroscopy study. PMID- 9939729 TI - Ionization energy and mobility measurement in Si:B. PMID- 9939730 TI - Many-particle exchanges in a class of correlated Gaussian wave functions for the fractionally quantized Hall effect. PMID- 9939731 TI - Balance-equation analysis of linear and nonlinear electronic transport in quasi two-dimensional quantum-well superlattices. PMID- 9939732 TI - Influence of elastic and magnetic fields on the phonon scattering and thermal conductivity of acceptor defects in cubic semiconductors. PMID- 9939733 TI - Cyclotron mass of a polaron in two dimensions. PMID- 9939734 TI - Image potentials and an inverse dielectric response function for a semiconductor slab. PMID- 9939735 TI - Oxide traps in Si-SiO2 structures characterized by tunnel emission with deep level transient spectroscopy. PMID- 9939736 TI - Metastability and hysteresis in the low-frequency dielectric response of the charge-density wave in K0.3MoO3. PMID- 9939737 TI - Pseudopotential total-energy study of the transition from rhombohedral graphite to diamond. PMID- 9939738 TI - Theoretical calculation of the pure electronic spectrum of MnF6 4- in vacuo and in RbMnF3. PMID- 9939739 TI - Relationship between the Auger line shape and the electronic properties of graphite. PMID- 9939740 TI - Core-exciton decay and change in the valence-band spectra of LiCl and LiBr. PMID- 9939741 TI - Pressure-induced phase transition in SrF2: A Raman study. PMID- 9939742 TI - Dipolar and quadrupolar freezing in (NaCN)1-x(KCN)x. PMID- 9939743 TI - Band structure and heat capacity of low-coverage helium films on noble-gas-plated graphite. PMID- 9939744 TI - F -center production in alkali halide crystals by monochromatic x-ray and ultraviolet radiation. PMID- 9939746 TI - Polarized Raman study of phonon modes perturbed by the off-center Li+ impurity in KCl. PMID- 9939745 TI - Lifetime effects in low-stage intercalated graphite systems. PMID- 9939747 TI - Possibility of the simultaneous occurrence of potential minima along two crystallographic directions in an octahedral potential. PMID- 9939748 TI - Electron dynamics in a crystal. PMID- 9939749 TI - Green's functions for interstitial impurities. PMID- 9939750 TI - Cohesive energy of beryllium calculated with the use of the charge-shift model. PMID- 9939751 TI - Surface Brillouin scattering in polycrystalline gold. PMID- 9939753 TI - Dissociative valence force field potential for silicon. PMID- 9939752 TI - Electronic structure of free carriers in quantum wells calculated by density functional theory. PMID- 9939754 TI - Anisotropy in the reflectivity measurements of bismuth germanate. PMID- 9939755 TI - Capacitance transient studies of a metastable defect in silicon. PMID- 9939756 TI - First-principles calculation of the pressure coefficient of the indirect band gap and of the charge density of C and Si. PMID- 9939757 TI - Low-temperature thermal expansion of glassy solids. PMID- 9939758 TI - Comment on "Observation of an index-of-refraction-induced change in the Drude parameters of Ag films." PMID- 9939759 TI - Reply to "Comment on 'Observation of an index-of-refraction-induced change in the Drude parameters of Ag films.' " PMID- 9939760 TI - Exchange and correlation energy in a nonuniform fermion fluid. PMID- 9939761 TI - Erratum: Raman study of phonon anharmonicity in LaF3 PMID- 9939763 TI - Theory of intermediate-valence solids. PMID- 9939762 TI - Temperature-dependent electronic excitations of the Ge(111)-2 x 1 surface. PMID- 9939764 TI - Influence of coadsorbed K on near-edge resonances for core and valence photoionization of CO on Ni(111). PMID- 9939766 TI - Au surface density of states and surface core-level shifts in Cu3Au(001). PMID- 9939765 TI - Photoabsorption shape resonance in the adsorption system CO/K/Cu(100): A dilemma. PMID- 9939767 TI - Magnetoconductance oscillations of a quasi-one-dimensional electron gas in a parabolic transverse potential. PMID- 9939769 TI - Destruction of phase coherence by electron-phonon interactions in disordered conductors. PMID- 9939768 TI - Renormalization-group analysis of the spin susceptibility of an interacting disordered electron system. PMID- 9939771 TI - Identification of the arsenic-antisite-arsenic-vacancy complex in electron irradiated GaAs. PMID- 9939772 TI - Strain-induced ordering in silicon-germanium alloys. PMID- 9939770 TI - Thermally modulated photoluminescence in GaxIn1-xAs-InP quantum wells. PMID- 9939774 TI - Magnetoplasmon-phonon coupling in a two-dimensional electron gas. PMID- 9939773 TI - Structural studies of Si(111)2 x 1 surfaces using low-energy electron diffraction. PMID- 9939776 TI - Stacking sequences in close-packed metallic superlattices. PMID- 9939775 TI - Metastable states of the repinned charge-density wave and the approach to equilibrium. PMID- 9939777 TI - Paramagnetic resonance of a new-oxygen-donor related center in silicon. PMID- 9939778 TI - Low-voltage breakdown of the quantum Hall state in a laterally constricted two dimensional electron gas. PMID- 9939779 TI - Atomic and electronic contributions to Si(111)-(7 x 7) scanning-tunneling microscopy images. PMID- 9939780 TI - Lattice distortions for arsenic in single-crystal silicon. PMID- 9939781 TI - Impact ionization mechanism for self-generated chaos in semiconductors. PMID- 9939782 TI - Ground state for the fractional quantized Hall effect. PMID- 9939783 TI - Q-factors of quartz oscillator modes as a probe of submonolayer-film dynamics. PMID- 9939784 TI - Two-level systems in electron-irradiated quartz. PMID- 9939786 TI - Dangling bond in amorphous hydrogenated silicon: Anomalous spin relaxation. PMID- 9939785 TI - Shear modulus of Laughlin-type wave functions. PMID- 9939787 TI - Double electron-muon resonance of anomalous muonium in silicon. PMID- 9939789 TI - Experimental application of the new orientational dynamic theory of ESR fine structure centers in an amorphous matrix. PMID- 9939788 TI - Electronic structure and magnetic and hyperfine properties of Fe/V sandwiches and interfaces. PMID- 9939790 TI - Variable-energy positron-beam studies of Ni implanted with He. PMID- 9939791 TI - Exchange-coupled pairs of Yb3+ ions in SrF2. PMID- 9939792 TI - White lines in the L2,3 electron-energy-loss and x-ray absorption spectra of 3d transition metals. PMID- 9939793 TI - Muonium centers in the cuprous halides. PMID- 9939794 TI - Magnetic susceptibility and ESR of the organic conductor bis(ethylenedithiolo) tetrathiafulvalene perchlorate PMID- 9939795 TI - Theory of the transferred hyperfine interaction between well-separated atoms and the influence of soft-phonon modes. PMID- 9939796 TI - Superconducting-transition temperatures of rare-earth rhodium boride compounds, RRh4B4. PMID- 9939797 TI - Electron inelastic scattering in aluminum films and wires at temperatures near the superconducting transition. PMID- 9939798 TI - Ultrasonic attenuation and the resistive transition in a superconducting granular lead film. PMID- 9939800 TI - Nonperturbative theory of exchange and correlation in one-electron quasiparticle states. PMID- 9939799 TI - Effect of quantum noise and tunneling on the fluctuational voltage-current characteristics and the lifetime of the zero-voltage state in Josephson junctions. PMID- 9939801 TI - Temperature dependence of the dynamical response of an electron on a thin liquid helium film. PMID- 9939802 TI - Theory of the upper critical field of a magnetic superconductor. PMID- 9939803 TI - Polarization study of Raman scattering of liquid 4He under pressure. PMID- 9939805 TI - Far-infrared absorption of thin superconducting aluminum films in the pair breaking and paramagnetic limits. PMID- 9939804 TI - Master-equation approach to shot noise in Josephson junctions. PMID- 9939806 TI - Effect of elastic boundary conditions on morphotropic Pb(Zr,Ti)O3 piezoelectrics. PMID- 9939808 TI - Status of understanding of the hybridization-mediated anisotropic magnetic behavior of PuSb. PMID- 9939807 TI - Scaling relations for grain autocorrelation functions during nucleation and growth. PMID- 9939810 TI - Assumption of separability of the excluded-volume interaction in polymer physics: Flory-Huggins theory reviewed. PMID- 9939809 TI - Transfer-matrix approach to estimating coverage discontinuities and multicritical point positions in two-dimensional lattice-gas phase diagrams. PMID- 9939811 TI - Specific-heat spectroscopy of glycerol and propylene glycol near the glass transition. PMID- 9939812 TI - Macromagnetism and micromagnetism in Ni-Mo metallic superlattices. PMID- 9939813 TI - Time-differential perturbed-angular-correlation study of K2HfF6 polymorphism. PMID- 9939815 TI - Behavior of wave functions in smooth aperiodic potentials: Anderson localization in the continuum. PMID- 9939814 TI - Point-defect-induced nucleation of the omega phase. PMID- 9939816 TI - Order-disorder dynamics of the ferroelectric phase transition in tris-sarcosine calcium chloride crystals. PMID- 9939817 TI - Correlation functions of the antiferromagnetic Heisenberg model using a modified Lanczos method. PMID- 9939819 TI - Magnetic properties of ferromagnet-antiferromagnet superlattice structures with mixed-spin antiferromagnetic sheets. PMID- 9939818 TI - Ferromagnetism in reentrant PdFex PMID- 9939821 TI - Temperature dependence of the response time of dilute metallic spin glasses. PMID- 9939820 TI - High-temperature series and the random-field Ising model. PMID- 9939822 TI - Soft modes in the one-dimensional Heisenberg antiferromagnet near saturation. PMID- 9939823 TI - Evidence of strong electron correlation effects on thermal expansion in transition metals. PMID- 9939824 TI - Amorphization of the Ising model with a transverse field: Transverse susceptibility. PMID- 9939825 TI - Steady and oscillatory cellular morphologies in rapid solidification. PMID- 9939826 TI - Scaling theory of pore growth in a reactive solid. PMID- 9939828 TI - Stability of incomplete explosive crystal growth. PMID- 9939827 TI - High-temperature spin dynamics of a cubic ferromagnet Pd2MnSn. PMID- 9939829 TI - Spin waves in a strong tight-binding itinerant ferromagnet with a (100) surface. PMID- 9939831 TI - Ferromagnetic phases of bcc and fcc Fe, Co, and Ni. PMID- 9939830 TI - Free-energy analysis of the single-q and double-q magnetic structures of neodymium. PMID- 9939833 TI - Specific heat of YbBe13. PMID- 9939832 TI - Solid-liquid interfacial energy of Ni40Pd40P20 alloy glass. PMID- 9939834 TI - Spin-1 model of a microemulsion. PMID- 9939835 TI - Vapor-phase growth of amorphous materials: A molecular-dynamics study. PMID- 9939836 TI - Continuous-symmetry ferromagnet with weak random magnetic anisotropy: A numerical study. PMID- 9939837 TI - Potts lattice-gas model for the solid-liquid interfacial tensions of simple fluids. PMID- 9939838 TI - Clock-model description of incommensurate ferroelectric films and of nematic liquid-crystal films. PMID- 9939839 TI - Electric-quadrupole interactions in mixed spinels. PMID- 9939840 TI - Thermofield transfer-matrix method and its applications to quantum spin systems. PMID- 9939841 TI - Power-law behavior in the viscosity of supercooled liquids. PMID- 9939843 TI - Anisotropic magnetoresistance with cubic anisotropy and weak ferromagnetism: A new paradigm. PMID- 9939842 TI - Finite-size effects at temperature-driven first-order transitions. PMID- 9939844 TI - Specific-heat study of random-field and competing-anisotropy effects in Fe1 xCoxCl2. PMID- 9939845 TI - Analysis of quasielastic light scattering in LiTaO3 near TC. PMID- 9939846 TI - Spin coupling between magnetic impurities in metals. PMID- 9939847 TI - Morin transition of shock-modified hematite. PMID- 9939849 TI - Kondo lattice and the formation of a heavy-fermion state. PMID- 9939848 TI - Monte Carlo renormalization-group study of the dynamics of the kinetic Ising model. PMID- 9939850 TI - Fractal nature of electrical conductivity in ion-implanted polymers. PMID- 9939851 TI - Correlation functions in the solid-on-solid model of the fluctuating interface. PMID- 9939852 TI - Dynamics of the classical Heisenberg ferromagnet. PMID- 9939854 TI - Theoretical investigation of Mossbauer isomer shifts in compounds of Sn, Sb, and Zn. PMID- 9939853 TI - Generalization of the Lloyd model for calculation of electronic structure at disordered interfaces. PMID- 9939855 TI - Tc suppression and critical fields in thin superconducting Nb films. PMID- 9939856 TI - Decay of a metastable state: A variational approach. PMID- 9939857 TI - Superconductivity in Bi observed with point contacts. PMID- 9939858 TI - Numerical studies of the field dependence of the magnetic specific heat of Eu0.25Sr0.75S and Eu0.54Sr0.46S. PMID- 9939859 TI - Monte Carlo versus Langevin methods for nonpositive definite weights. PMID- 9939860 TI - Brillouin scattering of rubidium iodide under high pressure. PMID- 9939862 TI - Anomalous electrical resistivity of the Kondo system Ce(Rh1-xCox)3B2. PMID- 9939861 TI - Measurement of spin-spin relaxation of 0.05-wt. % ruby. PMID- 9939863 TI - Large-cell Monte Carlo renormalization-group method for a new type of environmental percolation. PMID- 9939864 TI - Effects of finite geometry and boundary conditions on scattering functions at two dimensional critical points. PMID- 9939866 TI - Magnetic field effects on the optical spectrum of the quasi-one-dimensional ferromagnet CsFeCl3. PMID- 9939865 TI - Temperature-dependent cubic-lattice-model simulation of polymer-chain dynamics. PMID- 9939867 TI - Background fluctuations and Wegner corrections. PMID- 9939868 TI - Finite cutoff and higher transient effects on critical behavior. PMID- 9939869 TI - Intermediate phase between the alpha and beta phases of quartz. PMID- 9939871 TI - Erratum: Fermi-liquid theory of a pair of interacting Anderson impurities PMID- 9939870 TI - Reply to "Intermediate phase between the alpha and beta phases of quartz" PMID- 9939873 TI - Erratum: Phenomenological trends for heavy Fermi liquids and narrow-band metals PMID- 9939872 TI - Erratum: Anisotropic Heisenberg interface between Ising bulk ferromagnets: A renormalization-group approach PMID- 9939874 TI - Cross-section analysis of surface and bulk phonons by electron scattering from Cu(100). PMID- 9939875 TI - Internal field distribution on Au in the Au-Fe system in the limit of very small concentration. PMID- 9939876 TI - Epitaxial regrowth of an InAs surface on InP: An example of artificial surfaces. PMID- 9939877 TI - Stacking structure and superconductivity in ruthenium-iridium bicrystal superlattices. PMID- 9939878 TI - Resistance oscillations in a Josephson-junction array in a magnetic field. PMID- 9939879 TI - Evidence for a reversible structural transformation in the metallic glass Co58Ni10Fe5B16 Si11. PMID- 9939880 TI - Novel ordering in the XY spin glass. PMID- 9939881 TI - Pressure dependence of proton glass freezing in Rb1-x(NH4)xH2PO4. PMID- 9939882 TI - Fractal clustering of reactants on a catalyst surface. PMID- 9939883 TI - Global scaling properties of the spectrum for a quasiperiodic Schrodinger equation. PMID- 9939884 TI - Role of fluctuations in determining finite-size effects in a system undergoing a phase transition. PMID- 9939885 TI - Model with roughening transition at low temperatures. PMID- 9939886 TI - Thermodynamics of first-order and continuous melting of xenon on graphite. PMID- 9939888 TI - Monte Carlo study of Ising spin dynamics on a fractal lattice. PMID- 9939887 TI - Nonwetting growth and cluster formation of CF4 on graphite. PMID- 9939889 TI - Thermodynamics of a ferroelastic phase transition. PMID- 9939890 TI - Response of a purely dissipative incommensurate chain to large driving pulses. PMID- 9939891 TI - Electronic structures of amorphous Ni1-xPx glasses. PMID- 9939892 TI - Orbital forces and chemical bonding in density-functional theory: Application to first-row dimers. PMID- 9939893 TI - Electron liquid at any degeneracy. PMID- 9939894 TI - Monte Carlo simulation of continuous-space crystal growth. PMID- 9939895 TI - Calculation of impurity-vacancy and impurity-impurity interactions from enhancement of solvent and solute diffusion. PMID- 9939896 TI - Direct measurement of kinetic data by time-resolved high-resolution electron energy-loss spectroscopy. PMID- 9939898 TI - Perturbation-theory method of calculating the energies and excitation energies of atomic, molecular, and solid-state systems. PMID- 9939897 TI - Regular-dimerized stack and neutral-ionic interfaces in mixed-stack organic charge-transfer crystals. PMID- 9939899 TI - Transport equation for weakly localized electrons. PMID- 9939900 TI - Density-functional calculation of the fragmentation of doubly ionized spherical jelliumlike metallic microparticles. PMID- 9939901 TI - Transport of electron-hole plasma in germanium. PMID- 9939902 TI - Nonanalytic behavior of ultrasonic attenuation in disordered electronic systems. PMID- 9939903 TI - Electronic configuration of cerium in amorphous alloys investigated by x-ray absorption spectroscopy. PMID- 9939904 TI - L2,3-M4,5M4,5 Auger-electron spectra of the metallic elements 47Ag to 51Sb: An analysis of the main and satellite structures. PMID- 9939905 TI - Structural calculations for bulk As. PMID- 9939906 TI - Electronic structure of the (2 x 2)C rho 4g carbidic phase on Ni{100} PMID- 9939908 TI - Inertial dynamics of pinned charge-density-wave condensates. I. NbSe3. PMID- 9939907 TI - Acoustic and electronic properties of one-dimensional quasicrystals. PMID- 9939909 TI - Inertial dynamics of pinned charge-density-wave condensates. II. Orthorhombic TaS3. PMID- 9939910 TI - Photoelectron and bremsstrahlung spectra of Ce metals. PMID- 9939911 TI - Grain-boundary energies in metals from local-electron-density distributions. PMID- 9939913 TI - Localization in three-dimensional systems by a Gaussian random potential. PMID- 9939912 TI - Observation of two surface-plasmon modes on gold particles. PMID- 9939914 TI - Superposition-model analyses for the Cr3+ 4A2 ground state. PMID- 9939915 TI - Influence of exciton motion on the shape of optical absorption lines: Applications to vibrations at surfaces. PMID- 9939916 TI - Bulk band structure of chromium. PMID- 9939917 TI - Dynamic properties and Debye temperatures of bulk Au and Au clusters studied using extended x-ray-absorption fine-structure spectroscopy. PMID- 9939918 TI - Electronic structure of ferromagnetic iron: Band structure and optical properties. PMID- 9939919 TI - Generalization of the Lloyd model for calculation of electronic structure at disordered interfaces. PMID- 9939920 TI - Schottky-barrier heights of Ti and TiSi2 on n-type and p-type Si(100). PMID- 9939921 TI - Electron transport and pressure coefficients associated with the L1C and Delta 1C minima of germanium. PMID- 9939922 TI - Atomic configuration of hydrogenated and clean Si(110) surfaces. PMID- 9939923 TI - Recursion method in the k-space representation. PMID- 9939924 TI - Matrix atomic losses and oxygen incorporation under ruby-laser irradiation of silicon in gaseous atmospheres. PMID- 9939925 TI - Possible identification of zinc-vacancy-donor-impurity complexes in zinc telluride by optically detected magnetic resonance. PMID- 9939926 TI - Surface and bulk electronic structure of Ge(111) c(2 x 8) and Ge(111):As 1 x 1. PMID- 9939927 TI - Calculation of carrier capture time of a quantum well in graded-index separate confinement heterostructures. PMID- 9939928 TI - Landau-level broadening due to electron-phonon interaction in multiple-quantum well structures. PMID- 9939929 TI - Initial stages of the Schottky-barrier formation for an abrupt Al-GaAs(100) interface. PMID- 9939931 TI - Effect of static charge on the infrared spectrum of amorphous silicon. PMID- 9939932 TI - Time-resolved reflectivity measurements on silicon and germanium using a pulsed excimer KrF laser heating beam. PMID- 9939930 TI - Mobility in a quasi-one-dimensional semiconductor: An analytical approach. PMID- 9939934 TI - Relationship between path-integral and scaling theories of small polarons. PMID- 9939933 TI - Zone folding, morphogenesis of charge densities, and the role of periodicity in GaAs-AlxGa1-xAs (001) superlattices. PMID- 9939935 TI - Density-of-states investigation of C8K and occurrence of the interlayer band. PMID- 9939936 TI - Minimal basis sets in the linear muffin-tin orbital method: Application to the diamond-structure crystals C, Si, and Ge. PMID- 9939937 TI - Absorption and emission of radiation by plasmons in two-dimensional electron-gas disks. PMID- 9939939 TI - Threshold energy for atomic displacement in InP. PMID- 9939938 TI - Temperature dependence of the dielectric function and the interband critical points of CdSe. PMID- 9939940 TI - Photoconductivity and light-induced change in a-Si:H. PMID- 9939942 TI - Extended-state mobility and its relation to the tail-state distribution in a Si:H. PMID- 9939941 TI - Spectroscopy of a high-mobility GaAs-Ga1-xAlxAs one-side-modulation-doped quantum well. PMID- 9939943 TI - Theory of well-width-dependent periodic variation in photoluminescence from AlxGa1-xAs/GaAs quantum wells. PMID- 9939944 TI - Indirect band gap and band alignment for coherently strained SixGe1-x bulk alloys on germanium (001) substrates. PMID- 9939945 TI - Temperature-dependent absorption of aromatic molecules on silicon. PMID- 9939947 TI - Electroabsorption measurements of interfaces in a-Si:H/a-SiOx:H and a-Si:H/a SiNx:H multilayer films. PMID- 9939946 TI - Electronic structure of the carbon vacancy in NbC. PMID- 9939948 TI - Valence-bond theory of off-center impurities in silicon: Substitutional nitrogen. PMID- 9939949 TI - Exciton linewidth in semiconducting quantum-well structures. PMID- 9939950 TI - Thermodynamics of strain-confined paraexcitons in Cu2O. PMID- 9939951 TI - Voltage-induced anomalies in the coplanar conductance of amorphous semiconductor insulator multilayers. PMID- 9939952 TI - Optical properties of pure and ultraheavily doped germanium: Theory and experiment. PMID- 9939954 TI - Modeling of nonequilibrium melting and solidification in laser-irradiated materials. PMID- 9939953 TI - Excitation spectroscopy of the In-related isoelectronic bound exciton under uniaxial stress and magnetic-field perturbations. PMID- 9939955 TI - Effect of screening on the optical absorption of a two-dimensional electron gas in GaAs-AlxGa1-xAs heterostructures. PMID- 9939956 TI - Elastic anomalies in (V1-xCrx)2O3: Electron-transfer effects. PMID- 9939957 TI - Recursion method applied to a finite GaP cluster. PMID- 9939959 TI - Relativistic corrections to the Fermi energy in s-dimensional semiconductors. PMID- 9939958 TI - Effect of hydrostatic pressure and alloy composition on sulfur- and selenium related impurity states in heavily doped n-type GaxIn1-xSb. PMID- 9939960 TI - Pseudofunction method: Application to a monolayer of CO and to the Si(111) surface. PMID- 9939961 TI - Theory of the DX center in AlxGa1-xAs and GaAs crystals. PMID- 9939962 TI - Configuration-interaction calculations on the fractional quantum Hall effect. PMID- 9939963 TI - Thermodynamic properties of an interacting two-dimensional electron gas in a strong magnetic field. PMID- 9939964 TI - Excitation and ionization of Mo and W in GaAs. PMID- 9939965 TI - Electronic structure and positron states at vacancies in Si and GaAs. PMID- 9939966 TI - Initial stage of thermal oxidation of the Si(111)-(7 x 7) surface. PMID- 9939967 TI - Exciton dynamics in highly excited CdSe studied by picosecond gain-absorption spectroscopy. PMID- 9939968 TI - Phonon-fracton anharmonic interactions: The thermal conductivity of amorphous materials. PMID- 9939969 TI - Thermal quenching of chromium photoluminescence in ordered perovskites. I. Temperature dependence of spectra and lifetimes. PMID- 9939970 TI - Thermal quenching of chromium photoluminescence in ordered perovskites. II. Theoretical models. PMID- 9939971 TI - Lattice dynamics of the A15 compound Mo3Si. PMID- 9939973 TI - Phase separation and dynamical scaling in borate glasses. PMID- 9939972 TI - Dispersion of surface polaritons in uniaxial Al2O3. PMID- 9939974 TI - Lattice dynamics and phonon line shapes in 36Ar at high temperatures. PMID- 9939975 TI - Localized nature of the chemisorption bond: Configuration-interaction calculations of the chemisorption energies for Lin-H systems employing various localization procedures. PMID- 9939976 TI - Overlap interactions and bonding in ionic solids. PMID- 9939978 TI - Elastic and photoelastic anisotropy of solid HF at high pressure. PMID- 9939977 TI - Long-range interaction between rare-gas atoms or simple molecules and the surfaces of LiF, CaF2, sapphire, and BN. PMID- 9939979 TI - Polaronic states in a slab of a polar crystal. PMID- 9939981 TI - Methane adsorbed on graphite. III. The bilayer and trilayer. PMID- 9939980 TI - Dynamics of rare-gas floating monolayers in the self-consistent phonon theory. PMID- 9939982 TI - Scattering of helium atoms from rare-gas-plated graphite. PMID- 9939983 TI - Low-energy electron diffraction study of submonolayer mixtures of carbon monoxide and nitrogen with argon physisorbed on graphite. PMID- 9939984 TI - Formation of phonon-focusing caustics in crystals. PMID- 9939985 TI - Parametrization of the relaxation time in crystalline graphite. PMID- 9939986 TI - Anharmonicity and x-ray forbidden reflections in V3Si. PMID- 9939988 TI - Coulomb pseudopotential in some disordered Zr-based alloys. PMID- 9939987 TI - L2,3 absorption edges in Ni2Si. PMID- 9939990 TI - Electromagnetic properties of small metallic spheres: Diffuse surface scattering. PMID- 9939989 TI - Temperature-dependent far-infrared absorption of silver smoke. PMID- 9939991 TI - Coverage dependence of the work function of metals upon alkali-metal adsorption. PMID- 9939992 TI - Determination of surface-polariton minigaps on grating structures: A comparison between constant-frequency and constant-angle scans. PMID- 9939993 TI - Twin-boundary energies and entropies in simple metals: A constant-pressure Monte Carlo calculation. PMID- 9939995 TI - Optical phonon frequencies in the quaternary CdTe1-x-ySexSy mixed system. PMID- 9939994 TI - Energy dissipation processes in scanning tunneling microscopy. PMID- 9939996 TI - Size dependence in small-system calculations for fractional quantum Hall states. PMID- 9939998 TI - Exciton absorption tails in one-dimensional systems. PMID- 9939997 TI - Optical properties of amorphous multilayer structures. PMID- 9939999 TI - Photoconductivity and optical absorption coefficients near the band edge of phenazine-tetracyanoquinodimethane. PMID- 9940000 TI - Spin-orbit splitting in semiconductors and insulators from the ab initio pseudopotential. PMID- 9940001 TI - Heterojunctions: Definite breakdown of the electron affinity rule. PMID- 9940002 TI - Spin-reversed quasiparticles in the fractional quantum Hall effect: Many-body approach. PMID- 9940003 TI - Chaos in inelastic light scattering in dielectric crystals. PMID- 9940004 TI - Polarization of the x-ray-induced blue luminescence in quartz. PMID- 9940005 TI - Two-photon spectroscopy in KCl:Eu2+ PMID- 9940006 TI - Directional Compton profiles and autocorrelation function of magnesium oxide. PMID- 9940007 TI - Specific heat of melanin at temperatures below 3 K. PMID- 9940008 TI - Surface states of ordered Au, Ag, and Cu overlayers on Si(111) studied by inverse photoemission. PMID- 9940009 TI - New type of surface atomic vibrational modes of the (100) surface of the NaCl type lattice. PMID- 9940010 TI - Multiple-scattering approach to the propagation of electromagnetic waves in heterogeneous media. PMID- 9940012 TI - Transition to Ohmic conduction in ultrasmall tunnel junctions. PMID- 9940011 TI - Erratum: Observation of the Nyquist phase-coherence time in thin Au-Pd wires PMID- 9940013 TI - Structure and magnetism of quasicrystalline and crystalline Al1-xMnx alloys. PMID- 9940015 TI - Characterization of the heavy-fermion system CeCu6 by high-energy electron spectroscopies. PMID- 9940014 TI - Induced torque of sodium. PMID- 9940016 TI - Final-state screening of core holes in metals. PMID- 9940018 TI - Structural changes in the discommensurate distortion waves of NbTe4 on cooling. PMID- 9940017 TI - Surface structural determination for a weakly ordered and a disordered phase of Cl on Ag(111). PMID- 9940019 TI - Time-differential perturbed-angular-correlation study of the electric field gradient in amorphous Zr68Hf PMID- 9940020 TI - Quasicrystalline transformation by ion irradiation. PMID- 9940021 TI - Triplet solitonic excitations in trans-polyacetylene. PMID- 9940022 TI - Photoluminescence line shape of excitons in alloy semiconductors. PMID- 9940023 TI - Two-dimensional density of states in the extreme quantum limit. PMID- 9940025 TI - Effect of quantum hopping on the Coulomb gap of localized electrons in disordered systems. PMID- 9940024 TI - Statistical model for inhomogeneities in a two-dimensional electron gas implying a background density of states between Landau levels. PMID- 9940026 TI - Polarization dependence of Si(111)-2 x 1 surface-phonon and surface-state excitations. PMID- 9940028 TI - Si(111)7 x 7-Ge and Si(111)5 x 5-Ge surfaces studied with angle-resolved photoemission. PMID- 9940027 TI - Angle-resolved photoelectron-spectroscopy study of the Si(111) sqrt 3-bar x sqrt 3-bar-Sn surface: Comparison with Ssi(111) sqrt 3-bar x sqrt 3-bar-Al, -Ga, and In surfaces. PMID- 9940029 TI - Integral quantum Hall effect in superlattices. PMID- 9940031 TI - Effective mass of a space-charge layer on GaAs in a parallel magnetic field. PMID- 9940030 TI - Systematic investigation of picosecond photoinduced absorption in hydrogenated amorphous silicon. PMID- 9940033 TI - Raman scattering involving umklapp processes in Si/GexSi1-x superlattices. PMID- 9940032 TI - Thermal equilibration in doped amorphous silicon. PMID- 9940034 TI - Microscopic wave functions for the fractional quantized Hall states at nu =2/3 and 2/7. PMID- 9940036 TI - Edge effects in Auger spectroscopy for the early transition metals. PMID- 9940035 TI - Nonradiative-recombination-enhanced defect-structure trans- formation in low temperature gamma -ray-irradiated InP. PMID- 9940037 TI - Incident beam effects in angle-resolved Auger electron spectroscopy. PMID- 9940039 TI - Production of energetic positronium at metal surfaces. PMID- 9940038 TI - EPR study of vanadium (4+) in the anatase and rutile phases of TiO2. PMID- 9940040 TI - Range profiles of 25-100-keV neon ions in eleven elemental solids. PMID- 9940041 TI - EPR of Mn2+ in Fe(NH4)2(SO4)2 PMID- 9940043 TI - Cluster distribution in paraelectric KH2AsO4. I. Dispersion of the proton spin lattice relaxation time. PMID- 9940042 TI - Electron-nuclear double-resonance experiments in hydrogenated amorphous silicon. PMID- 9940044 TI - Cluster distribution in paraelectric KH2AsO4. II. 75As spin-spin and spin-lattice relaxation. PMID- 9940046 TI - Observation of a fluxon-antifluxon collision in a Josephson transmission line. PMID- 9940045 TI - Two-photon absorption in lanthanide complexes. PMID- 9940047 TI - Strongly disordered superfluids: Quantum fluctuations and critical behavior. PMID- 9940048 TI - Field-induced reentrant superconductivity in the Heusler alloy system Pd2Y1 xDyxSn. PMID- 9940049 TI - Properties of superconducting high-pressure phases of silicon. PMID- 9940050 TI - Superconductivity in sulfur-based organic superconductors: A volume property. PMID- 9940051 TI - New phase diagram in superconducting superlattices. PMID- 9940052 TI - Renormalization and phase transitions in Potts phi3-field theory with quadratic and trilinear symmetry breaking. PMID- 9940054 TI - Antiferromagnetic planar-rotator model under hn fields. PMID- 9940053 TI - Phase transitions in two-dimensional uniformly frustrated XY spin systems. PMID- 9940055 TI - Ferromagnetic resonance studies of very thin cobalt films on a gold substrate. PMID- 9940056 TI - Thermal behavior of the two-exciton bands in MnF2 and RbMnF3. PMID- 9940057 TI - Correlations in the two-dimensional random-field Ising model. PMID- 9940058 TI - Spin-glass transition in amorphous Tb-Si films. PMID- 9940059 TI - Connection between world-line and determinantal functional-integral formulations of the Hubbard model. PMID- 9940060 TI - Correlated random walks on two-sublattice systems. I. Theory. PMID- 9940061 TI - Correlated random walks on two-sublattice systems. II. Monte Carlo simulations. PMID- 9940063 TI - Degeneracy and quantum effects in the Hubbard model. PMID- 9940062 TI - Ethylene on graphite: Heats of adsorption and phase diagram. PMID- 9940064 TI - Wetting of a binary liquid mixture on glass. PMID- 9940065 TI - Anisotropy of critical correlations in moderately delocalized cerium and actinide systems. PMID- 9940066 TI - Heavy-fermion state in the Anderson lattice. PMID- 9940068 TI - Randomly closed Cayley trees and fractal dimensionality. PMID- 9940067 TI - Soliton diffusion in polyacetylene: Memory-function formalism. PMID- 9940070 TI - Magneto-optical study of the spin freezing in Hg1-xMnxTe semimagnetic semiconductors. PMID- 9940069 TI - High resolution electron microscopy of the triply incommensurate phase of 2H TaSe2. PMID- 9940071 TI - Nature of the surface-reconstruction phase transition and the high-temperature phase of clean W(001). PMID- 9940072 TI - Model study of the effect of surface steps and adsorbate-induced perturbations on the clean W(001) reconstruction transition. PMID- 9940073 TI - Phonons, phasons, and dislocations in quasicrystals. PMID- 9940074 TI - Multiatom interactions in the fcc Ising binary alloy: Low-temperature behavior and Monte Carlo simulations. PMID- 9940075 TI - Thermodynamics of field-induced spin-density-wave states in Bechgaard salts. II. PMID- 9940077 TI - Directional solidification with buoyancy in systems with small segregation coefficient. PMID- 9940076 TI - Quantum Monte Carlo and transfer-matrix calculations for one-dimensional easy plane ferromagnets. PMID- 9940078 TI - Holographic interference electron microscopy for determining specimen magnetic structure and thickness distribution. PMID- 9940079 TI - Distribution of shortest path lengths in percolation on a hierarchical lattice. PMID- 9940080 TI - epsilon expansion for transport exponents of continuum percolating systems. PMID- 9940081 TI - Spin dynamics of bound magnetic polarons in antiferromagnetic semiconductors. PMID- 9940082 TI - Series analysis of randomly diluted nonlinear resistor networks. PMID- 9940083 TI - Resistance of random Kronig-Penney potentials and the effects of phase-disrupting collisions. PMID- 9940084 TI - Conductivity of dispersed ionic conductors: A percolation model with two critical points. PMID- 9940085 TI - Superconductivity and magnetism of bcc Cr-Ru alloys. PMID- 9940086 TI - Percolative conduction in iodine-sulfur melts. PMID- 9940088 TI - Arrott-plot criterion for ferromagnetism in disordered systems. PMID- 9940087 TI - Structure-sensitive magnetic properties of reentrant Ni78Mn22. PMID- 9940089 TI - Enhanced transient effects due to saturated absorption of recoilless gamma radiation. PMID- 9940090 TI - Quantum specific heat of the easy-plane ferromagnetic chain: Application to CsNiF3 and (C6H PMID- 9940091 TI - Improved upper bounds on the critical temperature of the 1/n2 Ising spin chain. PMID- 9940092 TI - Reanalysis of "Dilute random-field Ising models and uniform-field antiferromagnets" PMID- 9940093 TI - Estimation of electron mobilities near the critical point in simple nonpolar fluids. PMID- 9940094 TI - Erratum: Spin waves and spin diffusion in Fermi liquids: Bounds on effective diffusion coefficients PMID- 9940095 TI - Evaporative cooling of magnetically trapped and compressed spin-polarized hydrogen. PMID- 9940097 TI - Optically detected magnetic resonance and spin coherence of self-trapped hole centers in an excited spin-quartet state in calcium oxide. PMID- 9940096 TI - Competition between the charge-density-wave and singlet-superconducting phases in a quasi-one-dimensional system. PMID- 9940098 TI - Effects of spin-orbit interaction and crystal fields on superconducting p-wave pair states and their collective excitations in cubic systems. PMID- 9940099 TI - Phase fluctuations in Josephson junctions. PMID- 9940100 TI - Effect of dissipation on the phase transition in granular superconductors. PMID- 9940101 TI - Parallel nucleation field in thin superconducting films. PMID- 9940102 TI - Bulk superconductivity of Hg3- delta AsF6. PMID- 9940103 TI - Analytic solution for fluxons in a long Josephson junction with surface losses. PMID- 9940104 TI - Hysteresis in rf-driven large-area Josephson junctions. PMID- 9940105 TI - Static and dynamic critical phenomena in Fe1-xZnxF2. PMID- 9940107 TI - Excited states and the metal-insulator transition in monovalent systems. PMID- 9940106 TI - Crystallization of icosahedral phase from glassy Pd-U-Si alloys. PMID- 9940108 TI - Experimental evidence for predicted universal behavior in low-temperature Kondo lattices. PMID- 9940109 TI - Minimal spanning tree: A new approach for studying order and disorder. PMID- 9940110 TI - Pressure-temperature phase boundaries in KC24: Evidence for a kinetically hindered low-temperature staging transition. PMID- 9940112 TI - Nonuniversality of diffusion exponents in percolation systems. PMID- 9940111 TI - Crossover from a hexatic phase to a single first-order transition in a Laplacian roughening model for two-dimensional melting. PMID- 9940113 TI - Change from diverging to finite susceptibility below Tc of the Heisenberg ferromagnet EuS. PMID- 9940115 TI - Wetting in two-dimensional systems with axially competing interactions. PMID- 9940114 TI - Relaxational dynamics for a class of disordered ultrametric models. PMID- 9940116 TI - Random walks on Cayley trees as models for relaxation in a hierarchical system. PMID- 9940117 TI - Maximum-entropy method for electronic properties of alloys. PMID- 9940118 TI - Electronic structure of chromium and manganese impurities in copper. PMID- 9940119 TI - Electronic structure of gold: An angle-resolved photoemission study along the Lambda line. PMID- 9940120 TI - Effect of stacking faults on diffraction: The structure of lithium metal. PMID- 9940122 TI - Dipolar interactions between dangling bonds at the (111) Si-SiO2 interface. PMID- 9940121 TI - Electronic surface states in beryllium. PMID- 9940124 TI - Dynamic localization of a charged particle moving under the influence of an electric field. PMID- 9940123 TI - Valence bands of KHgC4 and KHgC8. PMID- 9940125 TI - Density matrix of interacting boson-fermion systems as functional integrals in the holomorphic representation. PMID- 9940127 TI - Mean-field approximation for the molecular polaron with q2 coupling. PMID- 9940126 TI - Functional integral for the molecular polaron with q2 coupling. PMID- 9940128 TI - Topological constraints on quasicrystal transformations. PMID- 9940129 TI - High-resolution inverse-photoemission study of the Pd(111) surface. PMID- 9940130 TI - Localization by electric fields in one-dimensional tight-binding systems. PMID- 9940132 TI - Unified theory of segregated-stack organic charge-transfer solids: Magnetic properties. PMID- 9940131 TI - Azimuthal dependence of angle-resolved photoemission cross section from adsorbate induced initial states. PMID- 9940134 TI - Chemical effect on K beta :K alpha x-ray intensity ratios. PMID- 9940133 TI - Local-field corrections for sum-frequency generation from centrosymmetric media. PMID- 9940136 TI - Electromagnetic response of an array of particles: Normal-mode theory. PMID- 9940135 TI - Golden-rule approach to the soft-x-ray-absorption problem. IV. Numerical analysis. PMID- 9940137 TI - X-ray-photoemission-spectroscopy and bremsstrahlung-isochromat-spectroscopy study of the (Y,U)B4 system. PMID- 9940138 TI - Interaction of oxygen with sodium at 80 and 20 K. PMID- 9940139 TI - Self-consistent model of hydrogen chemisorption on ferromagnetic transition metals. PMID- 9940140 TI - Overlap integral between two electron clouds at different sites. PMID- 9940142 TI - Photoemission from small palladium clusters supported on various substrates. PMID- 9940143 TI - Importance of vertex corrections for obtaining correct selection rules in the theory of photoemission. PMID- 9940141 TI - Theory of the dc conductivity for the two-dimensional superionic conductor AgCrS2. PMID- 9940144 TI - Adsorbate-geometry determination by measurement and analysis of angle-resolved photoemission extended-fine-structure data: Application to c(2 x 2)S/Ni(001). PMID- 9940145 TI - Electron-positron density-functional theory. PMID- 9940146 TI - Atom-phonon interactions studied using a consistent quantum treatment. PMID- 9940147 TI - Defect states in substoichiometric tantalum carbide. PMID- 9940148 TI - Electronic and vibrational modes on a Penrose lattice: Localized states and band structure. PMID- 9940150 TI - Magnetic properties of binary intermetallic Zintl phases of the B32 type. PMID- 9940149 TI - Practical implementation and remaining problems for the film linearized muffin tin orbital calculation of surface electronic structure. PMID- 9940152 TI - Screened electromagnetic propagators in nonlocal metal optics. PMID- 9940151 TI - Electronic structure of ScN. PMID- 9940153 TI - Optical properties of oxidized granular silver. PMID- 9940154 TI - Self-similar ground-state wave function for electrons on a two-dimensional Penrose lattice. PMID- 9940155 TI - Molecular-dynamics simulation of silicon clusters. PMID- 9940156 TI - Valence-band coupling and Fano-resonance effects on the excitonic spectrum in undoped quantum wells. PMID- 9940157 TI - Thermalization of photoexcited localized excitons in GaSe samples with stacking disorder. PMID- 9940158 TI - Theory of cyclotron resonance of a quasi-two-dimensional electron gas in a quantum well. PMID- 9940159 TI - Self-consistent calculations of depletion- and accumulation-layer profiles in n type GaAs. PMID- 9940160 TI - Imaging of large-k phonons in InSb. PMID- 9940162 TI - X-ray vibrational studies on (100)-oriented CdTe crystals as a function of the temperature (8-350 K). PMID- 9940163 TI - Analysis of electromagnetic modes of aluminum-aluminum-oxide-gold tunnel junctions. PMID- 9940161 TI - Field-induced exchange effects in (Cd,Mn)Te and (Cd,Mn)Se from photoluminescence measurements. PMID- 9940164 TI - Surface vibrational spectroscopy studies of aromatic-molecule fragmentation on silicon surfaces. PMID- 9940165 TI - Vibronic coupling and the near-infrared spectrum of Fe2+ in CdTe and ZnS. PMID- 9940167 TI - Soft-x-ray photoemission study of Cr-Ge intermixing on crystalline and amorphous Ge surfaces. PMID- 9940166 TI - Magneto-optics in GaAs-Ga1-xAlxAs quantum wells. PMID- 9940168 TI - Electric-field-induced Raman scattering: Resonance, temperature, and screening effects. PMID- 9940170 TI - Calculation of the mobility and the Hall factor for doped p-type silicon. PMID- 9940169 TI - Polar-optical-phonon contribution to the damping of the magnetophonon oscillations in multiple-quantum-well structures. PMID- 9940171 TI - Irradiation-induced defects in p-type GaAs. PMID- 9940172 TI - Crystalline As2Se3: Electronic and geometric structure. PMID- 9940173 TI - Ultrasonic attenuation in electron-hole liquids. PMID- 9940174 TI - Recombination at dangling bonds and steady-state photoconductivity in a-Si:H. PMID- 9940175 TI - Co1+(3d8) double acceptor state in GaAs. PMID- 9940176 TI - Electronic structure of generic semiconductors: Antifluorite silicide and III-V compounds. PMID- 9940177 TI - Effect of the Mn-Mn exchange interaction on the high-field magnetoresistance and magnetization in n-type Hg1-x-yCdxMnyTe. PMID- 9940178 TI - Surface generation and detection of phonons by picosecond light pulses. PMID- 9940179 TI - Solitons, polarons, and phonons in the infinite polyyne chain. PMID- 9940180 TI - Photoemission spectroscopy of Yb3Si5 and its connection with Si-Yb interfaces. PMID- 9940181 TI - Theory of pressure effects on nonradiative capture. PMID- 9940183 TI - Electronic structure of hydrogenated fluorinated amorphous GaAs alloys. PMID- 9940182 TI - Stark-Wannier resonances and delocalization in one-dimensional incommensurate systems with a finite electric field. PMID- 9940184 TI - Condon domains in the two-dimensional electron gas. I. Domain-to-vortex transition. PMID- 9940185 TI - Condon domains in the two-dimensional electron gas. II. Charging effects. PMID- 9940186 TI - Condon domains in the two-dimensional electron gas. III. Dynamical effects. PMID- 9940188 TI - FA(Li) centers in mixed crystals of alkali halides. PMID- 9940187 TI - Magnetoresistance and Hall effect near the metal-insulator transition of Cd1 xMnxSe. PMID- 9940189 TI - Laser-excited site-selective spectroscopy of Eu3+ in sphene (CaTiSiO5) and glasses and glass ceramics of the sodium-calcium-aluminum titanosilicate system. PMID- 9940191 TI - Thermodynamic character of the vibron frequencies and equation of state in dense, high-temperature, fluid N2. PMID- 9940190 TI - Laser-induced refractive-index gratings in Eu-doped glasses. PMID- 9940192 TI - Relaxation effects in graphite intercalation compounds. PMID- 9940193 TI - Anticorrelation between yields of recombination luminescence and recombination induced defect formation in alkali-metal halides. PMID- 9940194 TI - Dielectric parameters of alkali halides. PMID- 9940196 TI - Quantitative approach to the off-center model in CuCl. PMID- 9940195 TI - Raman and infrared spectra of the incommensurate crystal Na2CO3. PMID- 9940198 TI - Calculation of the mobility of electrons injected in liquid xenon. PMID- 9940197 TI - X-ray-absorption study of CuBr at high pressure. PMID- 9940199 TI - Synchrotron-radiation-excited angle-resolved photoemission from single-crystal graphite. PMID- 9940200 TI - Low-temperature anomalies in the thermoelectric power of highly oriented graphite. PMID- 9940201 TI - Acoustic symmetry and vibrational anharmonicity of rhombohedral Pb5Ge3O11 and Pb4.7Ba0.3Ge3O11. PMID- 9940203 TI - Mutual influence of energy transfer and lattice phonons. PMID- 9940202 TI - Optical study of the K-point pi -band dispersion in graphite-H2SO4. PMID- 9940204 TI - dc transport in metals. PMID- 9940206 TI - Cutkosky rules for condensed-matter systems. PMID- 9940205 TI - Electronic and structural investigations of palladium clusters by x-ray absorption near-edge structure and extended x-ray absorption fine-structure spectroscopies. PMID- 9940207 TI - Thermal diffusivity measurement using the photopyroelectric effect. PMID- 9940208 TI - Inapplicability of the Sugiyama phase sum rule to very thin films. PMID- 9940209 TI - New high-energy approximation for x-ray-absorption near-edge structure. PMID- 9940211 TI - Stability of the EL2 center in GaAs under electron-hole recombination conditions. PMID- 9940210 TI - Vibrational dephasing of terminally bonded CO on Ru(001). PMID- 9940212 TI - Localized states in the barrier of superlattices. PMID- 9940213 TI - Evolution of the lattice spacing and damage in tantalum tritide. PMID- 9940214 TI - Investigations of the transverse bulk polaritons in uniaxial Al2O3 by infrared reflection. PMID- 9940215 TI - Annealing and relaxation in the high-pressure phase of amorphous SiO2. PMID- 9940216 TI - Erratum: One-body models for transport properties of valence fluctuators: Exact results PMID- 9940217 TI - Influence of the electron-electron interaction on the Aharonov-Bohm effect. PMID- 9940218 TI - Specific-heat anomaly of Au(110)(1 x 2) studied by low-energy electron diffraction. PMID- 9940219 TI - Induced-moment magnetic form factor of the heavy-fermion superconductors UPt3, UBe13, and CeCu2Si2. PMID- 9940220 TI - Temperature dependence of photoelectron scattering from a monolayer. PMID- 9940222 TI - Probability distributions in the scaling theory of localization. PMID- 9940221 TI - Quasiperiodic metallic multilayers: Growth and superconductivity. PMID- 9940224 TI - Density-functional theory for two noninteracting spinless fermions. PMID- 9940223 TI - Electron spectroscopy study of the growth of Mo on Al at low temperature: Relevance for cluster physics. PMID- 9940225 TI - Self-consistent Hartree-Fock and screened-exchange calculations in solids: Application to silicon. PMID- 9940227 TI - Population relaxation time of nonequilibrium LO phonons and electron-phonon interactions in GaAs-AlxGa1-xAs multiple-quantum-well structures. PMID- 9940226 TI - Electron heating in a multiple-quantum-well structure below 1 K. PMID- 9940228 TI - States at epitaxial NiSi2/Si heterojunctions studied by deep-level transient spectroscopy and hydrogenation. PMID- 9940229 TI - 1/f noise in GaAs: Evidence of a new scale invariance. PMID- 9940230 TI - Quasi-two-dimensional excitons in a strongly localized regime in CdTe-ZnTe superlattices. PMID- 9940231 TI - Electronic g factor in Si inversion layers under parallel magnetic fields. PMID- 9940233 TI - Excess low-temperature specific heat in K0.3MoO3. PMID- 9940232 TI - Layer-thickness dependence of cw photoluminescence in single a-Si:H layers. PMID- 9940234 TI - Ionization of impurity bound states in the quantized Hall effect. PMID- 9940235 TI - Photofield-emission spectroscopy of bulk electronic states of tungsten. PMID- 9940236 TI - Channeling study of amorphous phase formation in Nisub3B by ion implantation. PMID- 9940237 TI - Anisotropic muonium with random hyperfine distortions: A new static relaxation theory. PMID- 9940238 TI - Temperature dependence of hyperfine magnetic fields in Fe-Ni. PMID- 9940239 TI - Inelastic gas-surface scattering. I. Formalism. PMID- 9940240 TI - Spin delocalization of interstitial iron in silicon. PMID- 9940241 TI - Dynamics of a disordered monatomic solid with continuous distribution of force constants. PMID- 9940243 TI - Theory of in situ measurement of wave-vector-dependent dynamic susceptibility and ESR spectroscopy using the ac Josephson effect. PMID- 9940242 TI - Determination of the electronic configuration of the ground state of iron dimer through analysis of 57mFe Mossbauer data. PMID- 9940245 TI - Superconductivity, normal-state resistivity, and magnetic susceptibility of amorphous Zr-Co alloys. PMID- 9940244 TI - Electron-phonon interactions and superconductivity in Si, Ge, and Sn. PMID- 9940246 TI - Superconductivity in the ternary rare-earth (Y, La, and Lu) compounds RPd2Si2 and RRh2Si2. PMID- 9940247 TI - Variational Monte Carlo calculations of ground states of liquid 4He and 3He drops. PMID- 9940248 TI - Inelastic electron-tunneling study of MgO barriers. PMID- 9940249 TI - Electronic phase transition and partially gapped Fermi surface in superconducting Lu5Ir4Si10. PMID- 9940250 TI - Magnetic field studies of superconducting UBe13 thin films. PMID- 9940251 TI - Extended x-ray-absorption fine-structure observation of collinear ordering of Fe Sn-Fe atoms in the Chevrel-phase superconductor SnFe0.05Mo6S8. PMID- 9940252 TI - Gravity effects on first-sound velocity near T lambda (P) in liquid 4He. PMID- 9940254 TI - Jump in current at the gap voltage in a superconducting junction. PMID- 9940253 TI - Quasiparticle magnetospectroscopy and penetration-depth anisotropy in superconducting aluminum. PMID- 9940256 TI - Critical-velocity effects in vibrating superleaks: Vortex nucleation processes. PMID- 9940255 TI - Strain-dependent magnetic anomalies in doped UPt3. PMID- 9940257 TI - ESR study of the concentrated spin glass a-MnSi. PMID- 9940258 TI - Powder EPR study of the Jahn-Teller effect and phase transition in Cu2+:ZnTiF PMID- 9940259 TI - Multiscaling approach in random resistor and random superconducting networks. PMID- 9940261 TI - Crystal data for high-pressure phases of silicon. PMID- 9940260 TI - Magnetic properties of various crystalline phases and amorphous Al-Si-Mn and Al Mn alloys. PMID- 9940262 TI - Diffraction from quasicrystals: Geometric structure factor. PMID- 9940264 TI - Lattice distortions and short-range magnetic order in classical magnetoelastic Heisenberg chains. PMID- 9940263 TI - Thermodynamic study of monolayer methane on graphite. PMID- 9940265 TI - Critical behavior of the three-dimensional site-random Ising magnet: MnxZn1-xF2. PMID- 9940266 TI - Elastic neutron and x-ray scattering studies of the incommensurate gamma phase of (C3H7NH3)2MnCl4. PMID- 9940267 TI - Microscopic theory of elastic softening in beta -NaN3. PMID- 9940269 TI - Monte Carlo studies of the dynamical response of quantum many-body systems. PMID- 9940268 TI - Mossbauer study of the local atomic environments in metastable crystalline Fe-B alloys. PMID- 9940270 TI - Minimum wave-localization length in a one-dimensional random medium. PMID- 9940272 TI - Multicritical points in an Ising random-field model. PMID- 9940271 TI - Transverse susceptibility for Ising systems: Direct calculation from the local magnetic field distribution. PMID- 9940273 TI - Experimental evidence and theoretical criteria for a local-field rotational correlation length in metallic spin glasses. PMID- 9940274 TI - Spin-disorder resistivity and crystalline field effects in TmH2. PMID- 9940275 TI - Effect of Coulomb repulsion between localized and extended states in the Anderson model. PMID- 9940276 TI - Thermopower and low-dc-field magnetization study of the layered FexZrSe2 compounds: Anderson-type localization and anisotropic spin-glass behavior. PMID- 9940277 TI - Critical behavior of a three-dimensional kinetic gelation model. PMID- 9940278 TI - Kinetics of phase transformation from PdSi to Pd2Si. PMID- 9940279 TI - Percolation at a surface: The surface fractal dimension. PMID- 9940280 TI - Phase transitions in a disordered granular superconductor near percolation. PMID- 9940281 TI - Short- and long-range correlations in the S=1/2 ferromagnetic chain system (C6D11ND3)CuBr3. PMID- 9940282 TI - Specific effect of hydrogen implantation in yttrium iron garnet and annealing behavior studied by conversion-electron Mossbauer spectroscopy. PMID- 9940283 TI - Unstable point domains in ferroelectrics. PMID- 9940285 TI - Determination of the 153Eu-151Eu quadrupole-moment ratio by excited-state optically detected nuclear magnetic resonance. PMID- 9940284 TI - Mean-field theory of structural phase transitions in the A'A"BX4-type compounds. PMID- 9940287 TI - f-wave correlations in superfluid 3He. PMID- 9940288 TI - Calculation of the pressure dependence of the superconducting transition temperature of aluminum. PMID- 9940286 TI - Magnetic field dependence of the critical superconducting current induced by the proximity effect in silicon. PMID- 9940289 TI - Calculation of magnetic transitions in RRh4B4 due to the Ruderman-Kittel-Kasuya Yosida interaction. PMID- 9940290 TI - Inverse-Cantor-bar model for the ac response of a rough interface. PMID- 9940291 TI - Effective dynamics in Monte Carlo simulations with multispin updatings. PMID- 9940292 TI - Internal structure of Neel lines in subdivided Bloch walls. PMID- 9940293 TI - Order of the phase transition in a three-dimensional Ising model with three-spin interactions. PMID- 9940294 TI - Order of phase transition for systems with multispin interactions: Monte Carlo simulations. PMID- 9940295 TI - Digital dynamics and chaotic behavior in Monte Carlo simulations of magnetic systems. PMID- 9940297 TI - Absence of small-scale structure in homogeneous superfluid turbulence. PMID- 9940296 TI - Spectral dimensionality and hyperscaling. PMID- 9940298 TI - Erratum: Electromagnetic absorption for a superconductor with states in the gap PMID- 9940299 TI - Electron-spin resonance in insulating doped semiconductors. PMID- 9940300 TI - Nonuniform local magnetism in Al-Mn quasicrystals. PMID- 9940301 TI - Upper critical field in anisotropic superconductors. PMID- 9940302 TI - Short-range order and phase diagram of a three-dimensional granular superconductor. PMID- 9940304 TI - Evidence for two superfluid transitions in 3He-4He films. PMID- 9940303 TI - Observation of inverse predissociation of spin-polarized atomic hydrogen at low temperatures. PMID- 9940305 TI - Threshold for superconductivity in ultrathin amorphous gallium films. PMID- 9940307 TI - Influence of spin-orbit scattering on the coexistence phase of the ferromagnetic superconductors ErRh4B4 and HoMo6S8. PMID- 9940306 TI - Effects of second sound on acoustic transmission at the solid-liquid 4He interface. PMID- 9940309 TI - Eigenfunctions of the small oscillations about the double-sine-Gordon kink. PMID- 9940308 TI - Random fields and the weakly first-order phase transition in superconductors. PMID- 9940310 TI - Higher-order phase field models and detailed anisotropy. PMID- 9940311 TI - Double-transition behavior induced by anisotropy. PMID- 9940312 TI - Low-temperature structural transition in KC24. PMID- 9940314 TI - Ferromagnetism, glassiness, and metastability in a dilute dipolar-coupled magnet. PMID- 9940313 TI - Theoretical explanation of the antiferromagnetic anisotropy in organic superconductors: A probe for the spin-density-wave amplitude and nesting vector. PMID- 9940315 TI - Self-trapping on a dimer: Time-dependent solutions of a discrete nonlinear Schrodinger equation. PMID- 9940316 TI - Quantum transverse Ising spin-glass model in the mean-field approximation. PMID- 9940317 TI - Yang-Lee edge singularity on fractals. PMID- 9940318 TI - Tunneling microscopy study of the graphite surface in air and water. PMID- 9940320 TI - Dynamical local-field factor in the response function of an electron gas. PMID- 9940319 TI - Lattice deformation in TaTx systems due to 3He production. PMID- 9940321 TI - First-principles study of the structural properties of alkali metals. PMID- 9940322 TI - Low-temperature polaron collision time. PMID- 9940325 TI - Hyperthermal alkali-ion scattering from a metal surface: A theoretical study of the potential. PMID- 9940323 TI - Positron-annihilation study of the half-metallic ferromagnet NiMnSb: Theory. PMID- 9940324 TI - Surface phonons of p(2 x 2) structures: The effect bond-stretching interactions. PMID- 9940326 TI - Localization problem and mapping of one-dimensional wave equations in random and quasiperiodic media. PMID- 9940327 TI - Void nucleation as a diffusive instability. PMID- 9940328 TI - Lattice thermal conductivity: A comparison of molecular dynamics and anharmonic lattice dynamics. PMID- 9940329 TI - Self-consistent calculation of electron-phonon couplings. PMID- 9940330 TI - Augmented partial sum rules for the analysis of optical data. PMID- 9940332 TI - Theoretical study of the molecular-to-nonmolecular transformation of nitrogen at high pressures. PMID- 9940331 TI - Soliton lattice structure and mid-gap band in nearly commensurate charge-density wave states. II. Self-similar band-structure and coupling-constant dependence. PMID- 9940334 TI - One- and two-hole excitation spectra of the Hubbard model in the non-half-filled case. PMID- 9940333 TI - Quantum adiabatic particle transport. PMID- 9940335 TI - Vibrational characteristics of silver clusters in surface-enhanced Raman scattering. PMID- 9940336 TI - Asymmetries in atomic intermixing at Au/Ge and Ge/Au interfaces. PMID- 9940337 TI - Identification of a metastable particle produced by electron-stimulated desorption: CO on W(100). PMID- 9940339 TI - Local order in quenched states of simple atomic substances. PMID- 9940340 TI - Analytical model for the dielectric response of brine-saturated rocks. PMID- 9940338 TI - Ligand-field theory of inductive effects in the photoelectron spectra of transition-metal compounds. PMID- 9940342 TI - Surface effects on the diamagnetic susceptibility and other properties of a low temperature electron gas. PMID- 9940341 TI - Investigation of the anisotropic deuterium ordering in alpha -LuD single crystals by resistivity and heat-capacity measurements. PMID- 9940344 TI - Role of electron-energy losses in bremsstrahlung isochromat spectroscopy. PMID- 9940343 TI - Numerical and analytic methods for the study of disordered alloy surfaces. PMID- 9940345 TI - Size-dependent valence change in small Pr, Nd, and Sm clusters isolated in solid Ar. PMID- 9940346 TI - Intraband and interband processes in the infrared spectrum of metallic aluminum. PMID- 9940347 TI - Phase shifts, image planes, and surface states at metal surfaces. PMID- 9940348 TI - Effective-range approximation for surface states in one dimension. PMID- 9940349 TI - Localization of electronic wave functions due to local topology. PMID- 9940350 TI - Disorder and coherence in heavy-fermion systems. PMID- 9940351 TI - Influence of the electron-phonon interaction on the Aharonov-Bohm effect. PMID- 9940352 TI - Angle-resolved x-ray photoemission from the valence bands of tungsten with high angular resolution and temperature variation. PMID- 9940354 TI - Application of the multiple-scattering X alpha self-consistent-field method to alloys: Fe-Te cluster. PMID- 9940353 TI - Exact results on optical bistability with surface plasmons in layered media. PMID- 9940355 TI - dc conductivity in one-dimensional incommensurate systems. PMID- 9940357 TI - Optical absorption edge in liquid semiconductor alloys Se1-xTlx. PMID- 9940356 TI - Illustration of the linear-muffin-tin-orbital tight-binding representation: Compact orbitals and charge density in Si. PMID- 9940358 TI - Self-consistent energy bands and formation energy of the (GaAs)1(AlAs)1(001) superlattice. PMID- 9940359 TI - Formation of localized electronic states in incommensurate one-dimensional charge density-wave systems due to phase and single-particle excitations. PMID- 9940360 TI - Chemical trends in the structural stability of binary crystals. PMID- 9940361 TI - Electronic structure of AlN. PMID- 9940362 TI - Plasmons in aperiodic structures. PMID- 9940364 TI - Momentum-dependent dielectric functions of oriented trans-polyacetylene. PMID- 9940363 TI - New technique in the calculation of defects in solids by molecular methods: Pure and Cu-doped ZnS. PMID- 9940365 TI - Effect of different cation-anion bond strengths on metal-ternary-semiconductor interface formation: Cu/Hg0.75Cd0.25Te and Cu/CdTe. PMID- 9940366 TI - Scanning tunneling microscopy of Si(001). PMID- 9940367 TI - Theory of the anharmonic damping and shift of the Raman mode in silicon. PMID- 9940368 TI - Optical properties of polytype semiconductor superlattices: Bulk and surface plasmons, Raman and electron-energy-loss spectra, and finite-size effects. PMID- 9940369 TI - High-pressure studies of luminescence from GaP and GaP:N diodes. PMID- 9940370 TI - Enhancement of Si oxidation by cerium overlayers and formation of cerium silicate. PMID- 9940372 TI - Electron correlation in semiconductors and insulators: Band gaps and quasiparticle energies. PMID- 9940371 TI - Phonon and plasmon deformation potentials of GaAs: Far-infrared study under uniaxial stress. PMID- 9940373 TI - Voltage-controlled dissipation in the quantum Hall effect in a laterally constricted two-dimensional electron gas. PMID- 9940374 TI - Photoproduction of neutral soliton pairs in trans-(CH)x. PMID- 9940375 TI - Indirect exchange interaction between Mn2+ ions in Pb1-xMnxTe. PMID- 9940376 TI - Optical constants of palladium silicides measured by a multiple-wavelength ellipsometer. PMID- 9940377 TI - Subpicosecond plasma dynamics and absorption saturation in GaAs. PMID- 9940378 TI - Dispersive corrections to continuum elastic theory in cubic crystals. PMID- 9940380 TI - Mechanism of current modulation by optic phonons in heterojunction tunneling experiments. PMID- 9940379 TI - Electric-dipole spin resonance in n-type Cd1-xMnxSe. PMID- 9940382 TI - Raman scattering in the presence of photoexcited nonequilibrium carriers in semiconductors: Theoretical considerations. PMID- 9940381 TI - Correlation effects and excited states in conjugated polymers. PMID- 9940383 TI - Evaluation of four-center integrals with the linear muffin-tin orbital tight binding method. PMID- 9940384 TI - Phonon-emission spectroscopy of a two-dimensional electron gas. PMID- 9940385 TI - Polarization and the Haldane-Anderson model of defects in nonmetals. PMID- 9940387 TI - Photogenerated exciton-breather state in trans-polyacetylene. PMID- 9940386 TI - Collective excitations in the fractional quantum Hall effect of a multicomponent fermion system. PMID- 9940388 TI - Experimental study of the band structure of GaP, GaAs, GaSb, InP, InAs, and InSb. PMID- 9940389 TI - Small-polaron conduction in Y2Ti2O7. PMID- 9940390 TI - Phonon scattering at electronically degenerate defect states: Theoretical approach and applications to acceptors in cubic semiconductors. PMID- 9940392 TI - Soliton width-relaxation effects in polyacetylene. PMID- 9940391 TI - Diffusion and relaxation of energy in disordered systems: Departure from mean field theories. PMID- 9940393 TI - Subband-Landau-level spectroscopy in GaAs-AlxGa1-xAs heterojunctions. PMID- 9940395 TI - Properties of the EL2 level in GaAs1-xPx. PMID- 9940394 TI - Termination of hierarchy of fractional quantum Hall states: Scaling of impurity effect. PMID- 9940397 TI - Theoretical calculations of heterojunction discontinuities in the Si/Ge system. PMID- 9940396 TI - Band-gap shifts in heavily p-type doped semiconductors of the zinc-blende and diamond type. PMID- 9940398 TI - Gate-controlled transport in narrow GaAs/AlxGa1-xAs heterostructures. PMID- 9940399 TI - Quasiparticle states in the fractional quantum Hall effect. PMID- 9940400 TI - Ordered-defect model for Si(001)-(2 x 8). PMID- 9940402 TI - Low-frequency modes in vitreous silica. PMID- 9940401 TI - Luminescence quenching in F centers under pressure. PMID- 9940403 TI - Velocity of moving edge dislocations in a crystalline solid. PMID- 9940404 TI - Phonon frequency shifts in an anharmonic lattice via the Wigner distribution function. PMID- 9940405 TI - Thermal conductivity of amorphous solids. PMID- 9940406 TI - Calculation of the FH(CN-)-center absorption bands in CsCl. PMID- 9940407 TI - Phonon localization in glasses. PMID- 9940409 TI - Influence of local-field effects upon the optical properties of trigonal selenium. PMID- 9940408 TI - Correlated ESR and thermoluminescence study of the PMID- 9940410 TI - Surface-phonon dispersion of the NbC(001) and TaC(001) surfaces: Double-shell model analysis. PMID- 9940411 TI - Indirect short-range interactions in insulators. PMID- 9940412 TI - Stochastic model of stage transformation in graphite intercalation compounds. PMID- 9940413 TI - Initial stages of hydride formation: Hydrogen on Ce(001). PMID- 9940414 TI - Density dependence of the dielectric constant of rare-gas crystals. PMID- 9940415 TI - Theory of the reionization process observed in low-energy He+-surface scattering. PMID- 9940416 TI - Luminescence polarization of dimer centers in KI:Tl+ crystals: Analysis of experimental data and structure of dimers. PMID- 9940417 TI - Multiple-scattering regime and higher-order correlations in x-ray-absorption spectra of liquid solutions. PMID- 9940418 TI - Classical dynamics study of the ion bombardment of ice. PMID- 9940419 TI - Phonon localization in aggregates. PMID- 9940420 TI - Brillouin scattering study of the phase transition in NaN3. PMID- 9940422 TI - Optical phonons and elasticity of diamond at megabar stresses. PMID- 9940421 TI - Raman scattering intensities of layered crystals. PMID- 9940423 TI - Simple model for the influence of impurity aggregates on the F-center production of alkali halides. PMID- 9940425 TI - Host lattices and superionic properties in beta - and beta "-alumina. I. Structures and local correlations. PMID- 9940424 TI - Profile structures of very thin multilayers by x-ray diffraction using direct and refinement methods of analysis. PMID- 9940426 TI - Host lattices and superionic properties in beta - and beta "-alumina. II. Homogeneity ranges and conductivities. PMID- 9940427 TI - Numerical solution of the Hartree-Fock equations for quasi-one-dimensional systems: Prototypical calculations on the (-H PMID- 9940428 TI - Interplanar binding in graphite studied with the Englert-Schwinger equation. PMID- 9940430 TI - Lattice dynamics of bcc Cs. PMID- 9940429 TI - Piezoelectricity and flexoelectricity in crystalline dielectrics. PMID- 9940432 TI - He-Ag(110) interaction potential by new bound-state-resonance measurements. PMID- 9940431 TI - Optical determination of the antiferromagnetic exchange constant between nearest neighbor Mn2+ ions in Zn0.95Mn0.05Te. PMID- 9940433 TI - Many-body effects on the appearance potential spectroscopy of metals. PMID- 9940435 TI - Disordered electron systems with Hubbard interaction. PMID- 9940434 TI - Quantum size effect in thin metal films. PMID- 9940436 TI - Surface segregation in the hydrogen-adsorbed Cu-Ni alloy. PMID- 9940437 TI - Ground-state symmetry of a generalized polaron. PMID- 9940438 TI - Electronic conductivity of Si(111)-7 x 7. PMID- 9940440 TI - Electric charge motion, induced current, energy balance, and noise. PMID- 9940439 TI - Charge-carrier dynamics in GaAs multiple quantum wells determined by contactless photoconductivity measurements. PMID- 9940441 TI - Cubic-crystal-field levels and functions: A group-theoretical computational approach. PMID- 9940442 TI - Comment on "Band nonparabolicity effects on weak-coupling polarons in compound semiconductors" PMID- 9940444 TI - Erratum: Magnetophonon oscillations in quasi-two-dimensional quantum wells PMID- 9940443 TI - Erratum: Electronic interlayer states in hexagonal boron nitride PMID- 9940445 TI - Non-muffin-tin potentials in multiple-scattering theory. PMID- 9940446 TI - Effective Landau theory for disordered interacting electron systems: Specific heat behavior. PMID- 9940447 TI - Modified Gutzwiller theory of the metal-insulator transition: Application to heavy-fermion systems. PMID- 9940448 TI - Infrared reflectivity and Raman scattering from midgap-state exciton-polaritons of X0.3MoO3 (X=K,Rb). PMID- 9940449 TI - Spectroscopy of single atoms in the scanning-tunneling microscope. PMID- 9940450 TI - High-resolution electron-energy-loss spectroscopy of hydrogen chemisorption at Nb(100) surfaces: Evidence for subsurface absorption sites. PMID- 9940451 TI - Cumulative disorder and x-ray line broadening in multilayers. PMID- 9940452 TI - Experimental discrimination of coherent and incoherent behavior in heavy-fermion materials. PMID- 9940454 TI - Disequilibration of the pinned charge-density-wave state by slight changes in temperature. PMID- 9940453 TI - Empty and occupied electronic states of CuxY PMID- 9940455 TI - Charge-density-wave magnetodynamics in NbSe3. PMID- 9940458 TI - Comparison of electronic properties of quasiperiodic and periodic lattices in two and three dimensions. PMID- 9940456 TI - Composition of Cu-Ni alloy surfaces. PMID- 9940457 TI - First-principles theory of tetrahedral bonding and crystal structure of lead. PMID- 9940459 TI - Spin-dependent momentum distribution in iron studied with circularly polarized synchrotron radiation. PMID- 9940460 TI - Current oscillations in charge-density-wave transport. PMID- 9940461 TI - Optical bowing in zinc chalcogenide semiconductor alloys. PMID- 9940462 TI - Magnetotransport properties of p-type HgTe-CdTe superlattices. PMID- 9940463 TI - Hole Hall-mobility enhancement of HgTe-Hg1-xCdxTe interfaces. PMID- 9940464 TI - Picosecond spectroscopy of hot anti-Stokes luminescence in GaAs. PMID- 9940465 TI - Unambiguous observation of the 2s state of the light- and heavy-hole excitons in GaAs-(AlGa)As multiple-quantum-well structures. PMID- 9940466 TI - Direct picture of the local electronic structure during the Si(111)7 x 7-Al Schottky-barrier formation process. PMID- 9940467 TI - Electronic transport in doped amorphous silicon. PMID- 9940468 TI - Picosecond time-resolved Raman studies of the expansion of the electron-hole plasma in GaAs-AlxGa1-xAs multiple-quantum-well structures. PMID- 9940469 TI - Observation of luminescence from the 2s heavy-hole exciton in GaAs-(AlGa)As quantum well structures at low temperature. PMID- 9940470 TI - Tunneling through indirect-gap semiconductor barriers. PMID- 9940471 TI - Theory of the hole subband dispersion in strained and unstrained quantum wells. PMID- 9940473 TI - Theory of off-center impurities in semiconductors. PMID- 9940472 TI - Resonant Raman scattering in p-type GaAs-AlxGa1-xAs-AlAs quantum wells. PMID- 9940474 TI - Arsenic overlayer on Si(111): Removal of surface reconstruction. PMID- 9940476 TI - Electron spin resonance in disordered metals. PMID- 9940475 TI - Phonon scattering at a crystal surface from in situ-deposited thin films. PMID- 9940477 TI - Electronic structure of the interstitial lithium-associated electron trap in crystalline quartz. PMID- 9940478 TI - Spectroscopy of dimerization in organic mixed-stack compounds and tetramethyl-p phenylene-diamine chloranil. PMID- 9940479 TI - Interstitial hydrogen in diamond: A detailed Hartree-Fock analysis. PMID- 9940480 TI - Secondary-electron emission and electron-energy-loss results on graphite single crystals. PMID- 9940481 TI - Optically detected low-field ESR in the metastable state of Tm2+:SrF2. I. ESR signals and cross relaxation. PMID- 9940482 TI - Optically detected low-field ESR in the metastable state of Tm2+:SrF2. II. Determination of the sign of the g factor. PMID- 9940483 TI - Electron energy loss by electron-hole excitations in ferromagnets: The near specular geometry. PMID- 9940484 TI - Spectroscopic studies of excited Tm3+ ions in CaF2 crystals. PMID- 9940486 TI - Positronium formation at physisorbed monolayer surfaces of argon, nitrogen, and oxygen on graphite. PMID- 9940485 TI - Spin-polarized Auger electron spectroscopy on Gd. PMID- 9940487 TI - Spin-polarization torsional spectroscopy in beta -phase palladium hydride. PMID- 9940489 TI - Microscopic probing of order-disorder versus displacive behavior in BaTiO3 by Fe3+ EPR. PMID- 9940488 TI - Luminescence of Cr3+ ions in mixed Na+-Cd PMID- 9940490 TI - Theory of the microwave-soliton or antisoliton interaction in Josephson tunnel junctions. PMID- 9940491 TI - Electrical transport properties of V3Si, V5Si3, and VSi2 thin films. PMID- 9940493 TI - Theory of condensates in superfluids. PMID- 9940492 TI - First and second sound in He films. PMID- 9940494 TI - Resistivity and magnetoresistance studies on superconducting A15 V3Ga, V3Au, and V3Pt compounds. PMID- 9940495 TI - Experiments with "doubly"-spin-polarized atomic hydrogen. PMID- 9940496 TI - Three-body recombination in spin-polarized atomic hydrogen. PMID- 9940497 TI - Solid helium. I. Ground-state energy calculated by a lowest-order constrained variation method. PMID- 9940499 TI - One-dimensional Ising model in a variety of random fields. PMID- 9940498 TI - Relativistic dynamics of sine-Gordon solitons trapped in confining potentials. PMID- 9940501 TI - Raman scattering study of the electronic and vibrational excitations in CeCu2Si2. PMID- 9940500 TI - Ground states of one-dimensional systems using effective potentials. PMID- 9940502 TI - Theory of the dynamic spin response function near the Kosterlitz-Thouless transition. PMID- 9940504 TI - Anisotropic exchange and spin dynamics in the type-I (-IA) antiferromagnets CeAs, CeSb, and USb: A neutron study. PMID- 9940503 TI - Magnetovolume in chromium. PMID- 9940506 TI - Generalized Langevin equation for an oscillator. PMID- 9940505 TI - Cluster-size distribution and the magnetic property of a Potts model. PMID- 9940507 TI - Dynamics of structural phase transitions in highly anisotropic systems. PMID- 9940508 TI - Corrections to power-law behavior in the Heisenberg antiferromagnet. PMID- 9940509 TI - Concentration dependence of hopping conductivity in granular metals. PMID- 9940510 TI - Triple-point wetting of neon films. PMID- 9940511 TI - Bispectral analysis of the driven sine-Gordon chain. PMID- 9940512 TI - Low-field magnetization and Mossbauer-effect investigations in (Fe65Ni35)1 x(Fe84Mn16)x alloys. PMID- 9940513 TI - Computer simulation of the three-dimensional short-range Heisenberg spin glass. PMID- 9940514 TI - Evidence for ferromagnetic order at gadolinium surfaces above the bulk Curie temperature. PMID- 9940515 TI - Microscopic theory of surface tension. PMID- 9940516 TI - Simulation of a charge-density-wave transition in a quasi-one-dimensional system. PMID- 9940517 TI - Phase diagrams and correlation exponents for quantum spin chains of arbitrary spin quantum number. PMID- 9940518 TI - Low-energy electron transmission and secondary-electron emission experiments on crystalline and molten long-chain alkanes. PMID- 9940520 TI - Lines and domain walls in dilute ferromagnets. PMID- 9940519 TI - Localization transition on the Bethe lattice. PMID- 9940521 TI - Effect of disordered concentrated nonmagnetic impurities on the periodic Anderson Hamiltonian in one dimension. PMID- 9940522 TI - Gutzwiller method for heavy electrons. PMID- 9940523 TI - Multicritical properties of uniaxial Heisenberg antiferromagnets. PMID- 9940524 TI - Antiferromagnetism and spin-glass order in Fe-, Ca-, and Al-substituted braunites Mn2+(Mn3+)6SiO12. PMID- 9940525 TI - Modified Migdal-Kadanoff renormalization for the Potts model. PMID- 9940526 TI - Phase separation: Statics and dynamics in a racemic molecular solid solution. PMID- 9940527 TI - Electronic conductivity of a charge-density-wave system in the presence of phi solitons. PMID- 9940528 TI - Significance of the bulk correlation length for wetting transitions. PMID- 9940529 TI - Three-dimensional Heisenberg ferromagnet: A series investigation. PMID- 9940530 TI - Actinide-3d-metal Laves-phase intermetallic compounds: Magnetism and electronic properties. PMID- 9940531 TI - Appearance of the itinerant-electron character in (Co0.6Ni0.4)78Si8B14 observed by the resonance-magnetic-field shift induced by current. PMID- 9940532 TI - Phason anisotropy and the nuclear magnetic resonance in potassium. PMID- 9940534 TI - Nuclear magnetic relaxation in fractal pores. PMID- 9940533 TI - ESR observation of temperature-dependent g shifts in submetallic P-doped Si at low temperatures. PMID- 9940535 TI - Superhyperfine structure in the EPR spectra of Mn2+ ions in PbTe. PMID- 9940536 TI - Bulk superconducting specific-heat anomaly in beta -di PMID- 9940537 TI - Observation of unexpected nonlinear effect in the magnetically generated superflow of 3He-A1. PMID- 9940538 TI - Elastic and plastic properties of the flux-line lattice in type-II superconductors. PMID- 9940539 TI - Effects of the phase periodicity on the quantum dynamics of a resistively shunted Josephson junction. PMID- 9940540 TI - Third sound and capillary condensation on a fractal surface. PMID- 9940541 TI - Exact Bethe-ansatz thermodynamics for the sine-Gordon model in the classical limit: Effect of long strings. PMID- 9940542 TI - Experimental proof of magnetic x-ray dichroism. PMID- 9940543 TI - EPR determination of three-dimensional correlations below the ferroelectric phase transition in pseudo-one-dimensional CsH2PO4:Cu2+ PMID- 9940545 TI - Analytical determination of the production rate of thermal sine-Gordon solitons. PMID- 9940544 TI - Solitons in the ferromagnetic antisymmetric exchange chain. PMID- 9940546 TI - Erratum: Coherence and pair-breaking effect in the heavy-fermion superconductor CeCu2Si2 PMID- 9940547 TI - Unusual low-temperature effects on the NMR line shapes in solid hydrogen. PMID- 9940548 TI - 19F nuclear relaxation at the interface between liquid 3He and a solid substrate at high field and low temperature. PMID- 9940549 TI - Electron-phonon coupling in UBe13: Absence of conventional superconductivity. PMID- 9940551 TI - Spin-fluctuation-mediated even-parity pairing in heavy-fermion superconductors. PMID- 9940550 TI - Measurement of thermal accommodation of spin-polarized hydrogen on a saturated 4He film at 0.18-0.4 K. PMID- 9940552 TI - Low-temperature phases of Xe on graphite. PMID- 9940553 TI - Heisenberg-Ising crossover in spin glasses. PMID- 9940555 TI - New phase-transition scenario for chiral and algebraic order in a generalized planar model. PMID- 9940554 TI - Antiferromagnetic order in U1-xThxPt3. PMID- 9940556 TI - Temperature dependence of paramagnetic neutron scattering from Heisenberg ferromagnets above Tc. PMID- 9940558 TI - Activated dynamic scaling in spin glasses above the freezing temperature. PMID- 9940557 TI - Internal dynamics of the double-sine-Gordon chain. PMID- 9940559 TI - Phonon and fracton vibrational modes in disordered harmonic structures: A self consistent theory. PMID- 9940560 TI - Domain-wall scaling near the Ising spin-glass transition. PMID- 9940561 TI - Critical fluctuations and phase transitions in the antiferromagnetic Potts model. PMID- 9940562 TI - Experimental application of the new orientational dynamic theory to resolved NMR quadrupole spectra in polycrystalline-amorphous matrices. PMID- 9940563 TI - Effective and Debye temperatures of Ti in TiC, TiO2, and TiH2. PMID- 9940564 TI - Temperature dependence of planar channeling radiation. PMID- 9940566 TI - Quantum-interference device without Josephson junctions. PMID- 9940565 TI - Optical spectroscopy of 3d7 and 3d8 impurity configurations in a wide-gap semiconductor (ZnO:Co,Ni,Cu). PMID- 9940567 TI - Superconductivity in the ferromagnetic phase of polycrystalline HoMo6S8 films. PMID- 9940568 TI - Effect of pressure on competing electronic correlations in the heavy-electron system URu2Si2. PMID- 9940569 TI - Effect of pressure and magnetic field on the electrical resistivity of UBe13. PMID- 9940571 TI - Static and dynamic properties of random-field systems. PMID- 9940570 TI - Influence of radiation-induced disordering on the superconducting transition temperature of Nb3Ir films. PMID- 9940572 TI - Dissociation of compound ions in a high electric field: Atomic tunneling, orientational, and isotope effects. PMID- 9940574 TI - X-ray determinations of the liquid-structure factor and pair-correlation function of 4He. PMID- 9940573 TI - Search for an ac Josephson effect in superfluid 4He using a low-frequency acoustic resonator. PMID- 9940576 TI - Electron tunneling spectroscopy of superconducting A15 V-Ga alloy films. PMID- 9940575 TI - Static properties of a particle coupled to a fermionic environment. PMID- 9940577 TI - Tunneling spectroscopy of a macroscopic variable. PMID- 9940579 TI - Multipair excitations and sum rules in interacting-electron systems. PMID- 9940578 TI - Electron and hole self-energy contributions to the dynamic structure factor in interacting-electron systems. PMID- 9940581 TI - Meissner effect in anisotropic superconductors. PMID- 9940582 TI - Cooper-pair states for heavy fermions in the atomic representation: UPt3. PMID- 9940580 TI - Vortex pinning in superlattices of ferromagnetic and nonmagnetic superconductors. PMID- 9940584 TI - Magnetostatic theory of collective excitations in ferromagnetic and antiferromagnetic superlattices with magnetization perpendicular to the surface. PMID- 9940583 TI - X-ray study of the order-disorder phase transition in the triiodide chain compound tetraphenyldithiapyranylidene iodide PMID- 9940585 TI - Transport properties of continuum systems near the percolation threshold. PMID- 9940586 TI - Monte Carlo study of a one-dimensional degenerate Hubbard model. PMID- 9940587 TI - Magnetic susceptibility of (VO)2P2O7: A one-dimensional spin-1/2 Heisenberg antiferromagnet with a ladder spin configuration and a singlet ground state. PMID- 9940588 TI - Time-dependent phase transformation in KTaO3:Li. PMID- 9940589 TI - Paramagnetic susceptibilities of the antiferromagnetic quantum chain copper chloride bis-dimethyl sulfoxide: Theory and experiment. PMID- 9940590 TI - Frequency-dependent equation of state of fused silica to 10 GPa. PMID- 9940591 TI - Model Hamiltonian for orientational order: Mean-field theory for hexagonal symmetry. PMID- 9940592 TI - Diffusion to nonoverlapping or spatially correlated traps. PMID- 9940593 TI - Soliton dynamics in a magnetic chain. I. Antiferromagnet. PMID- 9940594 TI - Soliton dynamics in a magnetic chain. II. Ferromagnet. PMID- 9940595 TI - Relaxation in spin glasses at weak magnetic fields. PMID- 9940596 TI - Paramagnetic spin fluctuations in an Fe65Ni PMID- 9940597 TI - Determination of the algebraic exponents near the melting transition of a two dimensional Lennard-Jones system. PMID- 9940598 TI - Parametric equation of state for the n-vector model and polymers. PMID- 9940599 TI - Langevin simulations of quantum systems. PMID- 9940600 TI - Mean-field renormalization group: Unified approach to bulk and surface critical behavior. PMID- 9940602 TI - Critical behavior of the n-vector model for 1= 10) in Mn2+-CdO which is treated in CS2 at 700 degreesC: An observation by ESR. PMID- 9940631 TI - Profiling multilayer structures with monoenergetic positrons. PMID- 9940632 TI - Theoretical investigation of the isomer shifts of the 119Sn Mossbauer isotope. PMID- 9940633 TI - EPR of Mn2+ in the Tutton salts M(NH4)2(SO4)2 PMID- 9940635 TI - Acoustic localization in one dimension in the presence of a flow field. PMID- 9940634 TI - Vortex dynamics in superfluid helium films. PMID- 9940637 TI - Temperature dependence of the critical Josephson current in superconductor insulator-normal-metal proximity junctions near Tc. PMID- 9940636 TI - Sound propagation in liquid helium near the lambda point. II. Ultrasonic attenuation. PMID- 9940638 TI - dc electrical resistivity and upper critical magnetic field of superconducting ternary silicides and germanides with the Sc5Co4Si10-type structure. PMID- 9940639 TI - Electron-phonon interaction and thermopower nonlinearities in Chevrel-phase compounds. PMID- 9940640 TI - Experimental tests for the quantum behavior of a macroscopic degree of freedom: The phase difference across a Josephson junction. PMID- 9940641 TI - Quasiparticle interaction in the Fermi liquid 3He. PMID- 9940642 TI - Solid helium. II. Pressure and compressibility calculated by a lowest-order constrained-variation method. PMID- 9940643 TI - Three-body correlations in liquid and solid 4He. PMID- 9940644 TI - Two competing interactions in the Anderson lattice model. PMID- 9940645 TI - Quantum effects in the current-voltage characteristic of a small Josephson junction. PMID- 9940646 TI - Ripplon dispersion and finite-range effects in the quantum-liquid surface. PMID- 9940647 TI - Abnormal threshold properties of fluxon propagation in a resistively coupled Josephson transmission line. PMID- 9940649 TI - Collective mode and structure factor of a Fermi-Bose mixture at tricriticality. PMID- 9940648 TI - Condensate fraction in superfluid 4He. PMID- 9940650 TI - Effect of spin scattering and magnetic order on the electronic heat capacity of magnetic superconductors. PMID- 9940651 TI - Strong-coupling theories for superconductors containing local spin fluctuations. PMID- 9940652 TI - Nature of the magnetic ground state in Fe-Ni Invar alloys. PMID- 9940653 TI - Spin-polarized Auger-electron spectroscopy. PMID- 9940654 TI - Morin temperature of annealed submicronic alpha -F2O3 particles. PMID- 9940655 TI - Structure factors associated with the melting of a (31) ordered phase on a centered-rectangular lattice gas: Effective scaling in a three-state chiral-clock like model. PMID- 9940656 TI - Electrical resistivity of icosahedral Mg-Al-Zn alloys. PMID- 9940657 TI - Neutron scattering and the critical behavior of the three-dimensional Ising antiferromagnet FeF2. PMID- 9940658 TI - Theory of nuclear spin-lattice relaxation of spin-polarized hydrogen on liquid helium-coated surfaces due to magnetic particles in the substrate. PMID- 9940659 TI - Theory of ferroelectricity: The polarizability model. PMID- 9940660 TI - Spin-wave gap in uniaxial spin glasses. PMID- 9940661 TI - Search for low-temperature staging transitions in stage-2 potassium-graphite intercalation compounds. PMID- 9940663 TI - Macroscopic theory of orientational ordering in rapidly solidified alloys. PMID- 9940662 TI - Effective-pair interactions in transition-metal alloys: A supercell total-energy approach. PMID- 9940664 TI - Commensurate-incommensurate transition of monolayer krypton on graphite by helium atom scattering. PMID- 9940665 TI - Helmholtz free energy of finite spin systems near criticality. PMID- 9940666 TI - Inelastic neutron scattering study of magnetic interactions in CsMnxMg1-xBr3. I. Spin waves in CsMnBr3. PMID- 9940667 TI - Inelastic neutron scattering study of magnetic interactions in CsMnxMg1-xBr3. II. Magnetic excitations in clusters of Mn2+ ions. PMID- 9940668 TI - Kondo effect versus indirect exchange in the two-impurity Anderson model: A Monte Carlo study. PMID- 9940669 TI - Magnetoresistance measurements on fractal wire networks. PMID- 9940671 TI - Metastable states in the random-field Ising model. PMID- 9940670 TI - Electron-spin-lattice relaxation of photoexcited triplet states in disordered organic solids. PMID- 9940672 TI - Random-anisotropy-axis magnet with infinite anisotropy. PMID- 9940673 TI - Symmetry analysis of the microstructure and phase transitions of a crystallographic space group: Applications. PMID- 9940674 TI - Interaction between localized moments in metals: A Monte Carlo study. PMID- 9940675 TI - High-resolution infrared spectroscopy of hydrogen impurities in strontium titanate. PMID- 9940677 TI - Thermodynamic analysis of interfacial transport and of the thermomagnetoelectric system. PMID- 9940676 TI - High-pressure x-ray-diffraction and optical-absorption studies of NH4I to 75 GPa. PMID- 9940678 TI - Finite-temperature magnetism of disordered Fe-Cr alloys. PMID- 9940679 TI - Branched polymers on fractal lattices. PMID- 9940680 TI - History effects, domains, and glass formation in the mixed cyanides. PMID- 9940681 TI - One-dimensional magnetism in copper phthalocyanine. PMID- 9940682 TI - Absolute measurement of the ordered magnetic moment in holmium-rich (Er1 xHox)Rh4B4. PMID- 9940684 TI - Magnetism and electronic transport in the concentrated Kondo system (UxLa1 x)2Zn17. PMID- 9940683 TI - Periodic Anderson model for four-site clusters. PMID- 9940685 TI - Z(N) model of grain-boundary wetting. PMID- 9940686 TI - Zeros of the partition function of Ising models on fractal lattices. PMID- 9940687 TI - Anomalous time correlations in quenched systems with continuous symmetry. PMID- 9940689 TI - Field-theoretic formulation of the randomly diluted nonlinear resistor network. PMID- 9940688 TI - Noise exponents of the random resistor network. PMID- 9940690 TI - Temperature, stress, and structural-relaxation dependence of the magnetostriction in (Co0.94/BFe0.06)75/BSi15B10 glasses. PMID- 9940691 TI - Mixed valence as an almost broken symmetry. PMID- 9940692 TI - Melting dynamics of NiSi2/Si under pulsed laser irradiation. PMID- 9940693 TI - 1/N expansion for the transport coefficients of the single-impurity Anderson model. PMID- 9940694 TI - Anderson localization of spin waves in random Heisenberg antiferromagnets. PMID- 9940696 TI - Inelastic neutron scattering study of the spin dynamics in Fe3Si above TC. PMID- 9940695 TI - Anomalous small-angle x-ray scattering determination of the partial structure factors and kinetic study of unmixed Cu-Ni-Fe alloys. PMID- 9940697 TI - Polymer correlation functions and spurious singularities in n=0 field theory. PMID- 9940698 TI - Magnetization transport across a ferromagnetic-paramagnetic interface. PMID- 9940699 TI - Theory of zero-field muon-spin relaxation in simple magnetic systems. PMID- 9940701 TI - Random walk on a chain with dynamic disorder due to correlations. PMID- 9940700 TI - Spin-wave modes in antiparallel magnetized ferromagnetic double layers. PMID- 9940702 TI - Three-body-interaction effects on the phase-transition and high-pressure behavior of divalent-metal oxides. PMID- 9940703 TI - Phase transitions in Rb2ZrF PMID- 9940704 TI - Theory of magnetic susceptibility of Bloch electrons in the presence of localized magnetic moments. PMID- 9940706 TI - Relaxation of muonium states in solids. PMID- 9940705 TI - Specific heat of pure and yttrium-doped dysprosium aluminum garnet (DAG) powder near TN. PMID- 9940708 TI - Third sound and superflow on a striped substrate. PMID- 9940707 TI - Crystalline electric field effects in UPt2Si2 and URu2Si2. PMID- 9940710 TI - Localization in a one-dimensional quasiperiodic Hamiltonian with off-diagonal disorder. PMID- 9940709 TI - Two-dimensional imaging of trapped magnetic flux quanta in Josephson tunnel junctions. PMID- 9940711 TI - One-dimensional randomness on a two-dimensional lattice: A soluble model. PMID- 9940713 TI - Low-temperature magnetoresistivity of Kondo systems: Comparison with experiments on Ce impurities in LaB6 and LaAl2. PMID- 9940712 TI - Models of magnetic-moment variation in alloys. PMID- 9940714 TI - Evidence for weak localization effects on the critical magnetic field for the amorphous alloys V1-xSix. PMID- 9940716 TI - Exact contact critical exponents of a self-avoiding polymer chain in two dimensions. PMID- 9940715 TI - Magnetic resonance line shape in the spin-glass Eu PMID- 9940717 TI - Continuum limit of the upper critical field Hc2 for superconducting networks. PMID- 9940718 TI - Erratum: White lines in the L2,3 electron-energy-loss and x-ray absorption spectra of 3d transition metals PMID- 9940719 TI - Erratum: Decay of a metastable state: A variational approach PMID- 9940720 TI - Differentiation of single versus multiple vibrational excitation processes on surfaces: An electron-energy-loss spectroscopy investigation of the Al2O3 vibrational modes. PMID- 9940721 TI - Positronium time-of-flight spectroscopy of dissimilar metals. PMID- 9940722 TI - Exact solution to a new anisotropic dimer model with domain-wall behavior. PMID- 9940724 TI - Time-of-flight spectroscopy of positronium emission from quartz and magnesium oxide. PMID- 9940723 TI - Extended fine structures in autoionization emission spectra of bulk chromium. PMID- 9940725 TI - Magnetization of superconducting lanthanum copper oxides. PMID- 9940727 TI - Energy gap in the high-Tc superconductor La1.85Sr0.15CuO4. PMID- 9940726 TI - Magnetic properties of a superconducting Ba-La-Cu oxide. PMID- 9940728 TI - Measurement of the superconducting energy gap in La-Ba-Cu oxide and La-Sr-Cu oxide. PMID- 9940729 TI - Far-infrared measurement of the energy gap of La1.8Sr0.2CuO4. PMID- 9940730 TI - Composition-dependent superconductivity in La2-xSrxCuO4- delta. PMID- 9940731 TI - Electronic properties of La2-xSrxCuO4 high-Tc superconductors. PMID- 9940732 TI - Normal- and superconducting-state properties of La1.85Sr0.15CuO4. PMID- 9940734 TI - Superconducting phase transitions in the La-M-Cu-O layered perovskite system, M=La, Ba, Sr, and Pb. PMID- 9940735 TI - Diatomic melting curves to very high pressure. PMID- 9940733 TI - Upper critical fields of high-Tc superconducting La2-xSrxCuO4-y: Possibility of 140 tesla. PMID- 9940736 TI - Direct observation of fluxon reflection in a Josephson transmission line. PMID- 9940737 TI - Weak localization effects on the upper critical field of bulk superconductors. PMID- 9940738 TI - Lattice instability and superconductivity in the Pb, Sn, and Ba Chevrel phases. PMID- 9940739 TI - CePtSi: A new heavy-fermion compound. PMID- 9940740 TI - Transverse sound in a magnetic field in UPt3. PMID- 9940741 TI - Hall-effect and resistivity study of the heavy-fermion system URu2Si2. PMID- 9940742 TI - Self-affine fractal model for a metal-electrolyte interface. PMID- 9940743 TI - Renormalization, self-similarity, and relaxation of order-parameter structure in critical phenomena. PMID- 9940745 TI - X-ray scattering study of charge-density waves in K3Cu8S6. PMID- 9940744 TI - Characterization of the microstructure of disordered media: A unified approach. PMID- 9940747 TI - Energy dispersion of image states and surface states near the surface-Brillouin zone boundary. PMID- 9940746 TI - Phase separation in amorphous Fe-Zr: Comparison of sputtered and solid-state reacted films. PMID- 9940748 TI - Continuum elasticity analysis of the enhanced modulus effect in metal-alloy superlattice films. PMID- 9940749 TI - Magnetite: Phonon modes and the Verwey transition. PMID- 9940750 TI - Two-level system with nonlinear coupling. PMID- 9940751 TI - Residual resistivity of defects in metals. PMID- 9940752 TI - Representation analysis of cooperative Jahn-Teller ordering. PMID- 9940753 TI - Enumeration of random packings for atomic substances. PMID- 9940754 TI - Green's-function calculations of 5s-5p x-ray photoemission spectra of Ra (Z=88) and Th (Z=90). PMID- 9940755 TI - Real-space formulation of the mixed-basis pseudopotential method: Bulk structural properties of elemental copper. PMID- 9940757 TI - Rudimentary quasicrystallography: The icosahedral and decagonal reciprocal lattices. PMID- 9940756 TI - Lattice relaxation at an aluminum surface: Self-consistent linear-electronic response approach. PMID- 9940758 TI - Hartree-Fock band-structure calculations with the linear muffin-tin-orbital method: Application to C, Si, Ge, and alpha -Sn. PMID- 9940759 TI - Monte Carlo evaluation of the diffusion correlation factor in concentrated lattices and comparison with an improved theory. PMID- 9940760 TI - Study of Bin p+ ions formed in liquid-metal ion sources. PMID- 9940762 TI - Defect recovery in aluminum irradiated with protons at 20 K. PMID- 9940761 TI - Photoemission studies of the initial adsorption and growth of Ag and Au on Ge and Si. PMID- 9940763 TI - Phonon dispersion curves in the lattice dynamics of iron. PMID- 9940764 TI - Surface reconstruction and vibrational excitations of Si(001). PMID- 9940765 TI - Surface-enhanced alloy effects on Hg1-xCdxTe(100) surface states and the site dependent coherent-potential approximation. PMID- 9940766 TI - Atomistic study of structural metastability in coherently strained Si-like layers. PMID- 9940767 TI - Inverse photoemission study of InP, InAs, and InSb. PMID- 9940769 TI - Temperature dependence of the shifts and broadenings of the critical points in GaAs. PMID- 9940768 TI - Inelastic light scattering by collective charge-density excitations in GaAs-Ga1 xAlxAs superlattices. PMID- 9940770 TI - Ab initio static dielectric matrices from the density-functional approach. I. Formulation and application to semiconductors and insulators. PMID- 9940771 TI - Ab initio static dielectric matrices from the density-functional approach. II. Calculation of the screening response in diamond, Si, Ge, and LiCl. PMID- 9940772 TI - Effects of local atomic arrangements on the densities of phonon states of Ga1 xInxAs, Ga1-xInxSb, GaAs1-xSbx, and InAs1-xSbx. PMID- 9940774 TI - Effect of hydrostatic pressure on GaAs-Ga1-xAlxAs microstructures. PMID- 9940773 TI - Theory of electron-energy-loss spectroscopy of surface and interface phonons in a two-medium target with a transverse boundary. PMID- 9940775 TI - Anomalous decay of photocurrent in amorphous thin films of Ge22Se78. PMID- 9940776 TI - Spin-orbit scattering time and dephasing time of carriers in two-dimensional HgTe CdTe superlattices and heterojunctions. PMID- 9940778 TI - Evidence of vacancy-induced surface states for nonstoichiometric TiNx(100). PMID- 9940777 TI - Vacancy-induced structures in the angle-resolved photoemission spectra of substoichiometric TiNx(100). PMID- 9940779 TI - Surface structure of (22) S/Ge(111) determined by angle-resolved photoemission fine structure. PMID- 9940780 TI - Detailed investigation of doping in hydrogenated amorphous silicon and germanium. PMID- 9940781 TI - Theory of the fractional quantum Hall effect. PMID- 9940782 TI - Electronic properties of a complex Cu-related acceptor with a bound exciton at 2.3423 eV in ZnTe. PMID- 9940783 TI - Electronic structure of a hole-attractive neutral Cu-related complex-defect bound exciton at 2.345 eV in ZnTe. PMID- 9940785 TI - Shifts and splittings of electron energy levels of A centers in silicon under uniaxial stress. PMID- 9940784 TI - Random walks in an exponential band. PMID- 9940787 TI - Influence of disorder on the electronic properties of the Si(111) surface. PMID- 9940786 TI - Voltage-controlled structure of certain p-n and p-i-n junctions. PMID- 9940788 TI - Lattice dynamics of the potential-induced breathing model: Phonon dispersion in the alkaline-earth oxides. PMID- 9940789 TI - Valence-band photoemission in UO2(111) near the 5d resonant photon energy. PMID- 9940790 TI - Hopping ionic conductivity in Ce-doped SrF2. I. Ionic thermocurrent results. PMID- 9940791 TI - Hopping ionic conductivity in Ce-doped SrF2. II. Results obtained from impedance measurements. PMID- 9940793 TI - Ab initio calculations of the excitonic spectra of the alkali iodides including relativistic effects. PMID- 9940792 TI - Surface dynamics of relaxed (001) slabs of alkali halides and MgO. PMID- 9940794 TI - Theory of F centers in the alkaline-earth oxides MgO and CaO. PMID- 9940795 TI - Magnetic specific heat of CoCl2 and FeCl3 intercalated in graphite. PMID- 9940796 TI - Interaction of SO2 with nearly perfect and defect TiO2(110) surfaces. PMID- 9940797 TI - Four-wave-mixing measurements of energy migration and radiationless relaxation processes in alexandrite crystals. PMID- 9940798 TI - Orientational order in nitrogen monolayers adsorbed on graphite at low temperature. PMID- 9940799 TI - Magnetic behavior and crystal field of Dy(BrO3)3 PMID- 9940801 TI - Modified Sjolander-Stott integral equation for the electron distribution around an impurity. PMID- 9940800 TI - Pressure coefficients of band gaps of diamond. PMID- 9940802 TI - Correlation between 1/f noise and grain boundaries in thin gold films. PMID- 9940803 TI - Ab initio phonon quantities of simple metals from Hartree-Fock cluster techniques. PMID- 9940804 TI - Response functions for single interfaces and layered structures. PMID- 9940805 TI - Two-photon absorption in semiconducting quantum-well structures. PMID- 9940806 TI - Formation of CrSi and CrSi2 upon annealing of Cr overlayers on Si(111). PMID- 9940807 TI - Defect-concentration dependence of the charge-density-wave transport in tetrathiafulvalene tetracyanoquinodimethane. PMID- 9940808 TI - Coupled intra- and intersubband plasmon-phonon modes in double heterostructures. PMID- 9940809 TI - Erratum: Au-GaAs(110) interface: Photoemission studies of the effects of temperature PMID- 9940810 TI - Evolution of a surface state into an interface state: A probe of the buried epitaxial Cr/Au(100) interface. PMID- 9940812 TI - Surface extended-x-ray-absorption fine-structure study at the carbon K edge: The p4g(22)-C/Ni(100) system. PMID- 9940811 TI - Characteristic times for the field-activated relaxation of the charge-density wave in K0.3MoO3. PMID- 9940814 TI - Effects of gravity on equilibrium crystal shapes: Droplets hung on a wall. PMID- 9940813 TI - Spectroscopic evidence for an unrealized heavy-electron state in CeAl2. PMID- 9940815 TI - Potassium-induced empty electronic states on Ag(110). PMID- 9940816 TI - Photoemission study of ammonia dissociation on Si(100) below 700 K. PMID- 9940817 TI - Photoconductivity in trans-polyacetylene. PMID- 9940818 TI - Hydrogen passivation of boron acceptors in silicon: Raman studies. PMID- 9940820 TI - Need for an acceptor level in the AsGa-Asi model for EL2. PMID- 9940819 TI - Free-carrier screening of the interaction between excitons and longitudinal optical phonons in InxGa1-xAs-InP quantum wells. PMID- 9940821 TI - Analysis of the asymmetry in Shubnikov-de Haas oscillations of two-dimensional systems. PMID- 9940823 TI - Role of coherences in the relaxation of adsorbates. PMID- 9940822 TI - Observation of driven surface-plasmon modes in metal particulates above tunnel junctions. PMID- 9940825 TI - Quantum theory of the sticking of an atom on a cold solid: Gettering-theory approach. PMID- 9940824 TI - Theory of cyclotron resonance in an electron-phonon system. PMID- 9940827 TI - Short-range-force indicator for closed-shell ions based on orbital moments: Crystal-structure preference. PMID- 9940826 TI - Quantum effects in sticking and inelastic scattering of hydrogen and deuterium on metals, with electron-hole pair excitations. PMID- 9940828 TI - Size and temperature effects on the Seebeck coefficient of thin bismuth films. PMID- 9940830 TI - Diffraction from disordered one-dimensional islands with domain boundaries: Intensity behavior for various statistical approximations. PMID- 9940829 TI - Surface electron-energy-loss fine-structure investigation on the local structure of copper clusters on graphite. PMID- 9940832 TI - Variation of the Pb and Bi 5d binding energies and branching ratios for thin Pb and Bi overlayers on Ni(110). PMID- 9940831 TI - Quantized Hall effect and geometric localization of electrons on lattices. PMID- 9940833 TI - Calculation of the Debye-Waller factor for atom-surface scattering: He on Ag(111). PMID- 9940834 TI - Electronic properties of perfect and nonperfect one-dimensional quasicrystals. PMID- 9940835 TI - Effect of chemical bonding on positive secondary-ion yields in sputtering. PMID- 9940837 TI - Hydrogen and deuterium decoration of In-vacancy complexes in nickel. PMID- 9940836 TI - Negative thermal expansion and valence fluctuation in quasi-one-dimensional platinum compounds. PMID- 9940838 TI - Point-defect anisotropic diffusion in strained hcp metals. PMID- 9940840 TI - Electronic transport in a superlattice with average periodic order. PMID- 9940839 TI - Energy-level correlation function and ac conductivity of a finite disordered system. PMID- 9940841 TI - Extended x-ray absorption fine structure of CO2 analyzed by a new algorithm. PMID- 9940842 TI - Moving discommensurations interacting with diffusing impurities. PMID- 9940843 TI - Raman line shifts of adsorbed molecules in surface Raman spectroscopy. PMID- 9940845 TI - One-dimensional theory for the lowest Landau level of a disordered two dimensional electron system. PMID- 9940844 TI - Quantum diffusion in a metallic environment. PMID- 9940846 TI - Electronic structure and binding energy of the AsGa-Asi pair in GaAs: EL2 and the mobility of interstitial arsenic. PMID- 9940847 TI - Interpretation of acceptor excitation spectra in uniaxially stressed germanium. PMID- 9940848 TI - Nonlinear density-matrix equation for the study of finite-temperature soliton dynamics. PMID- 9940849 TI - Acoustic deformation potentials and heterostructure band offsets in semiconductors. PMID- 9940850 TI - Electronic structure of MoSe2, MoS2, and WSe2. I. Band-structure calculations and photoelectron spectroscopy. PMID- 9940851 TI - Electronic structure of MoSe2, MoS2, and WSe2. II. The nature of the optical band gaps. PMID- 9940853 TI - Silicide formation at the Ti/Si(111) interface: Room-temperature reaction and Schottky-barrier formation. PMID- 9940852 TI - Optical evidence of the direct-to-indirect-gap transition in GaAs-AlAs short period superlattices. PMID- 9940854 TI - Fragmentation of silicon microclusters: A molecular-dynamics study. PMID- 9940855 TI - Energy cusps and incompressibility in the fractional quantum Hall effect. PMID- 9940856 TI - Use of few-domain classical models to study mode locking in charge-density-wave systems. PMID- 9940857 TI - Polaron mobility in trans-polyacetylene. PMID- 9940858 TI - Shallow donorlike impurity states in n-type InP in magnetic field and under hydrostatic pressure. PMID- 9940859 TI - Evolution of intermediate excitons in fluid argon and krypton. PMID- 9940860 TI - Nonlinear balance equations for hot-electron transport with finite phonon relaxation time. PMID- 9940861 TI - Deep-level transient spectroscopy studies of the interstitial carbon defect in silicon. PMID- 9940863 TI - Mixed conductivity and potential fluctuations in semi-insulating GaAs:Cr. PMID- 9940862 TI - Electrical study of Schottky-barrier heights on atomically clean p-type InP(110) surfaces. PMID- 9940864 TI - Thermalization and cooling processes in a dense photogenerated plasma in polar semiconductors: Effects of screening and phonon heating. PMID- 9940865 TI - Comparative study of Y and other transition metals on GaAs(110). PMID- 9940866 TI - Electron energy loss from collective excitations in superlattice structures: Sensitivity to the outermost layer. PMID- 9940867 TI - Surface mobility fluctuations in metal-oxide-semiconductor field-effect transistors. PMID- 9940869 TI - Charge-density-wave transport in quasi-one-dimensional conductors. II. ac-dc interference phenomena. PMID- 9940870 TI - Ballistic charge-carrier transport in semiconductor point contacts. PMID- 9940868 TI - Charge-density-wave transport in quasi-one-dimensional conductors. I. Current oscillations. PMID- 9940872 TI - Nonradiative energy transfer without lifetime quenching in doped Mn-based crystals. PMID- 9940871 TI - Balance equations for steady-state hot-electron transport in the approach of the nonequilibrium statistical operator. PMID- 9940873 TI - Sodium chloride structural properties: Linearized augmented-plane-wave calculations and pressure calibration. PMID- 9940874 TI - Influence of heat treatment on the relaxation ultrasonic attenuation due to two level systems in neutron-irradiated quartz. PMID- 9940875 TI - Ab initio calculations on bent-chain models of solid hydrogen fluoride. PMID- 9940876 TI - Structural model of Raman "defect" bands of vitreous silica. PMID- 9940877 TI - Photoemission from C8Rb and C4RbTl1.5: Effects of ternarization in donor graphite intercalates. PMID- 9940879 TI - Lattice spacing of hypothetical AgCl and AgBr with "switched-off" van der Waals interactions. PMID- 9940878 TI - Anisotropy and two-dimensional effects in the ESR properties of OsF6-graphite intercalation compounds. PMID- 9940880 TI - Mean-free-path concept in polycrystalline metals. PMID- 9940881 TI - Nonlinear elimination of magnetoresistance divergences due to Landau quantization. PMID- 9940882 TI - Magnetic field dependence of resonant tunneling in thin metal-oxide-semiconductor structures. PMID- 9940883 TI - Subbands in the gap in inverted-band semiconductor quantum wells. PMID- 9940884 TI - Analysis of pseudo-Jahn-Teller instability: O, S, and N- in silicon. PMID- 9940885 TI - Small-polaron transport in thin films of SiNx:H. PMID- 9940886 TI - Intensity oscillations for electron beams reflected during epitaxial growth of metals. PMID- 9940887 TI - Weak localization of photons and backscattering from finite systems. PMID- 9940889 TI - Heterojunction valence-band-discontinuity dependence on face orientation. PMID- 9940888 TI - Mass of a three-body complex on a lattice. PMID- 9940890 TI - 1H electron-nuclear-double-resonance-detected ESR of light-soaked undoped a-Si:H. PMID- 9940891 TI - Effect of chemical and elastic interactions on the phase diagrams of isostructural solids. PMID- 9940892 TI - Phonon sideband of quasi-two-dimensional excitons in GaAs quantum wells. PMID- 9940893 TI - New aspects of enhanced ion scattering near 180 degrees. PMID- 9940894 TI - Relaxation of nuclear and electronic magnetic moments in heavy-electron compounds. PMID- 9940895 TI - Rayleigh scattering and weak localization: Geometric effects and fluctuations. PMID- 9940896 TI - Theory of positronium formation with surface electrons for realistic band structures. PMID- 9940897 TI - Static quadrupolar perturbed NMR in structurally incommensurate systems. I. Electric-field-gradient tensor. PMID- 9940899 TI - Coherence lengths and neutron optics. PMID- 9940898 TI - Static quadrupolar perturbed NMR in structurally incommensurate systems. II. 87Rb satellite transitions in Rb2ZnBr4. PMID- 9940900 TI - Spin relaxation and diffusion in quasi-two-dimensional organic metals: The bis(ethylenedithiolo)tetrathiafulvalene compounds beta -(BEDT-TTF)2X (X=I PMID- 9940902 TI - Differential inelastic electron scattering cross sections from experimental reflection electron-energy-loss spectra: Application to background removal in electron spectroscopy. PMID- 9940901 TI - Damage processes and magnetic field orientation in ferrimagnetic oxides Y3Fe5O12 and BaFe12O19 irradiated by high-energy heavy ions: A Mossbauer study. PMID- 9940903 TI - Coulomb scattering in field and photofield emission. PMID- 9940904 TI - 61Ni Mossbauer study of the hyperfine magnetic field near the Ni surface. PMID- 9940905 TI - New evidence for the folding of surface phonon modes in quasimonatomic crystals from He time-of-flight measurements in NaF. PMID- 9940906 TI - Electron, muon, and nuclear spin dynamics in SmRh4B4 and ErRh4B4. PMID- 9940907 TI - NMR study of 1H and 205Tl in ammonium and thallium perchlorates in the rotating frame: Indirect measurement of the relaxation time of rare-spin 17O. PMID- 9940908 TI - 2H NMR studies of structural phase transitions in some members of the deuterated ABF6 PMID- 9940909 TI - Band-structure effects in photofield emission. PMID- 9940910 TI - Ambegaokar-Baratoff-Ginzburg-Landau crossover effects on the critical current density of granular superconductors. PMID- 9940911 TI - Functional derivatives of the current jump at the superconducting gap. PMID- 9940912 TI - Ortho-para dependence of the equation of state and the phonon frequency of solid hydrogen. PMID- 9940913 TI - Low-temperature heat-capacity study of superconducting ternary silicides and germanides with the Sc5Co4Si10-type structure. PMID- 9940915 TI - Theory of the effect of supercurrents on the low-voltage resistance of superconductor-insulator-normal-metal tunnel junctions. PMID- 9940914 TI - Wetting of gold-plated quartz by liquid 4He. PMID- 9940916 TI - Arbitrarily polarized model Fermi liquid. PMID- 9940918 TI - Interference effects in the R0(0) transition of solid HD. PMID- 9940917 TI - Fermi-surface instabilities and superconducting d-wave pairing. PMID- 9940920 TI - Crystal structure of the high-temperature superconductor La1.85Sr PMID- 9940919 TI - Gutzwiller-Hubbard lattice-gas model with variable density: Application to normal liquid 3He. PMID- 9940921 TI - Structural instability in single crystals of the high-Tc superconductor La2-x Srx CuO4. PMID- 9940922 TI - Two-phase sound in 3He-4He mixtures. PMID- 9940924 TI - Theory of the Kapitza resistance. PMID- 9940923 TI - Upper critical field of V-Ag multilayered superconductors. PMID- 9940926 TI - Self-consistent calculations of the pair potential and the tunneling density of states in proximity contacts. PMID- 9940925 TI - Maximum-overlap Jastrow wave function for liquid 4He. PMID- 9940927 TI - Control of a wetting transition by substrate surface chemistry: The interplay of long- and short-range forces. PMID- 9940928 TI - Supercooled liquids and solids in porous glass. PMID- 9940929 TI - Structure factors associated with melting of a p(22) ordered phase on a honeycomb lattice gas: Possible critical scattering at a first-order transition. PMID- 9940930 TI - Interface roughening and domain growth in the dilute Ising model. PMID- 9940931 TI - Anomalous thermal expansion of nonstoichiometric TmSe. PMID- 9940932 TI - Anisotropy in the paramagnetic phase of RAl2 cubic intermetallic compounds (R=Tb, Dy, and Er). PMID- 9940934 TI - Pressure-induced staging transitions and stage disorder in dilute potassium graphite intercalation compounds. PMID- 9940933 TI - Magnetic structure of Dy-Y superlattices. PMID- 9940935 TI - Linear crystal acoustics and piezoelectricity of incommensurate dielectrics. PMID- 9940936 TI - Magnetic structure of MnP as probed by 57Fe. PMID- 9940937 TI - Dynamics of droplet fluctuations in pure and random Ising systems. PMID- 9940938 TI - Percolation effects and magnetic properties of the randomly diluted fcc system CopMg1-pO. PMID- 9940939 TI - Quasiparticle spectrum of the Hubbard model. PMID- 9940940 TI - Magnetization of Zn0.95Mn0.05Te in magnetic fields up to 42 T. PMID- 9940941 TI - Elastic and magnetoacoustic effects in heavy-fermion CePb3. PMID- 9940942 TI - Investigation of the pressure-induced B3-B1 phase transition in Cd1-xMnxTe (0 <= x <= 0.70). PMID- 9940943 TI - Monte Carlo test of the Flory-Huggins theory for polymer mixtures. PMID- 9940944 TI - Random-field Ising model as a dynamical system. PMID- 9940945 TI - Ferromagnetism of CeSix at ambient and high pressure. PMID- 9940946 TI - High-field magnetization steps and the nearest-neighbor exchange constant in Cd1 xMnxS, Cd1-xMnxTe, and Zn1-xMnxSe. PMID- 9940947 TI - Localization and correlation effects in itinerant ferromagnets. PMID- 9940949 TI - Charge and magnetization perturbations around impurities in nickel. PMID- 9940948 TI - Effects of diffusing impurities on domain growth in the Ising model. PMID- 9940950 TI - Electron correlations in the effective-potential expansion method. PMID- 9940952 TI - Crystal structure, phase stability, and magnetism in Ni3V. PMID- 9940951 TI - Orientational order and solid-liquid coexistence in the two-dimensional Lennard Jones system. PMID- 9940953 TI - Ar-cluster-size distribution in a supersonic jet beam. PMID- 9940954 TI - Dynamics of magnetic-polaron formation in Cd1-xMnxSe and Cd1-xMnxTe. PMID- 9940956 TI - Randomly diluted xy and resistor networks near the percolation threshold. PMID- 9940955 TI - Ytterbium valence phase transition in YbxIn1-xCu2. PMID- 9940957 TI - Potts-model formulation of the random resistor network. PMID- 9940958 TI - Model study of the semiconductor-metal transition in BaBi1-xPbxO3 by use of a spatially inhomogeneous order-parameter approximation. PMID- 9940959 TI - Complete unbinding and quasi-long-range order in lamellar phases. PMID- 9940960 TI - Metastable phase equilibrium during solid-state amorphization reaction of Zr-Co layers. PMID- 9940961 TI - Dynamical corrections to density-functional theory for quasiparticles in ferromagnetic 4f systems. I. T=0 results for EuO. PMID- 9940963 TI - Low-temperature magnetic structure of FeSn2. PMID- 9940962 TI - Dynamical corrections to density-functional theory for quasiparticles in ferromagnetic 4f systems. II. Finite-temperature results for EuO. PMID- 9940964 TI - Directed percolation: "field" exponents and a test of scaling in two and three dimensions. PMID- 9940965 TI - Effect of oxygen on magnetism at the surface of Cr(100). PMID- 9940966 TI - Role of boundary conditions in the finite-size Ising model. PMID- 9940967 TI - Ferrimagnetism of Cu0.45Co0.55Cr2S4-ySey. PMID- 9940968 TI - Dimerization transition versus neutral-ionic transition in organic mixed-stack compounds. PMID- 9940969 TI - Real-space renormalization study of a quantum spin glass with Ruderman-Kittel Kasuya-Yosida interactions. PMID- 9940970 TI - Raman scattering in antiferromagnetic FePS3 and FePSe3 crystals. PMID- 9940971 TI - Kinetic theory of a quantum particle interacting with a dissipative environment. PMID- 9940973 TI - Test of s-wave pairing in heavy-fermion systems due to Kondo volume collapse. PMID- 9940972 TI - Glassy phase in an array of Josephson junctions. PMID- 9940974 TI - Superconductivity at 90 K in a multiphase oxide of Y-Ba-Cu. PMID- 9940975 TI - High-Tc superconductivity in regions of possible compound formation: Y2-xBaxCuO4 x/2+ delta and Y2-xBa1+xCu2O6-x/2+ delta. PMID- 9940976 TI - Bulk superconductivity at 36 K in La1.8Sr0.2CuO4. PMID- 9940977 TI - Determination of charge carriers in superconducting La-Ba-Cu-O by thermoelectric measurements. PMID- 9940978 TI - Two-dimensional plasmons in nonstoichiometric La2NiO PMID- 9940979 TI - Magnetic penetration depth and flux-pinning effects in high-Tc superconductor La1.85Sr0.15CuO. PMID- 9940980 TI - Magnetic field penetration depth of La1.85Sr0.15CuO4 measured by muon spin relaxation. PMID- 9940981 TI - Crystal structure of the high-Tc superconductor Ba2YCu3O9- delta. PMID- 9940982 TI - Temperature-dependent x-ray studies of the high-Tc superconductor La1.9Ba0.1CuO4. PMID- 9940983 TI - Neutron-diffraction and magnetization studies of UP0.80S0.20 single crystals: Observation of several incommensurate and field-induced ferrimagnetic phases. PMID- 9940984 TI - Localization in disordered chains with on-site Coulomb repulsion. PMID- 9940985 TI - Field quenching: A method to achieve a random initial state for aging experiments on spin glasses. PMID- 9940987 TI - Breakup of long-range order in the diluted antiferromagnet K2MnxZn1-xF4 in zero magnetic field. PMID- 9940986 TI - Electrical resistivity of amorphous Fe82B18-xGex alloys: Coherent electron-magnon scattering contribution. PMID- 9940988 TI - Monte Carlo renormalization-group study of the discrete Gaussian model. PMID- 9940989 TI - Localization properties of the one-dimensional Anderson model with a self-similar random potential. PMID- 9940990 TI - Resonant modes in Ising antiferromagnets at the critical magnetic field. PMID- 9940991 TI - Irreversibility lines in uniform anisotropic ferromagnets. PMID- 9940992 TI - Ground state of the uranium ion in a metal with large j PMID- 9940993 TI - Scaling theory of diffusion in the presence of large traps. PMID- 9940994 TI - Comment on "Amorphization of the Ising ferromagnet with a transverse field" PMID- 9940996 TI - Comment on "Temperature dependence of the response time of dilute metallic spin glasses" PMID- 9940995 TI - Reply to "Comment on 'Amorphization of the Ising ferromagnet with a transverse field' " PMID- 9940997 TI - Reply to "Comment on 'Temperature dependence of the response time of dilute metallic spin glasses' " PMID- 9940999 TI - Temperature and composition dependence of the tetragonal-orthorhombic distortion in La2-xSrxCuO4- delta. PMID- 9940998 TI - X-ray absorption studies of La2-x(Ba,Sr)xCuO4 superconductors. PMID- 9941000 TI - High-resolution synchrotron x-ray study of the structure of La1.8Ba0.2CuO4-y. PMID- 9941001 TI - Determination of valence of Cu in superconducting La2-x(Sr,Ba)xCuO PMID- 9941003 TI - Specific-heat measurements on two high-transition-temperature superconducting oxides: La1.85Ba PMID- 9941002 TI - X-ray-absorption studies of the high-Tc superconductors La1.8Sr0.2CuO4 and La1.8Ba0.2CuO4. PMID- 9941004 TI - Heat capacity of superconducting La1.85Sr0.15CuO4. PMID- 9941005 TI - Absence of specific-heat anomaly at the superconducting transition in La1.8Ba0.2CuO4-y. PMID- 9941006 TI - Local tunneling measurements of the high-Tc superconductor La2-xSrxCuO4-y. PMID- 9941007 TI - Measurements of the superconducting gap of La-Sr-Cu-O with a scanning-tunneling microscope. PMID- 9941008 TI - Energy gap in La1.85Sr PMID- 9941009 TI - Electron-tunneling studies of thin films of high-Tc superconducting La-Sr-Cu-O. PMID- 9941011 TI - X-ray identification of the superconducting high-Tc phase in the Y-Ba-Cu-O system. PMID- 9941010 TI - Observation of a low-energy infrared anomoly in superconducting La1.85Sr0.15CuO4. PMID- 9941012 TI - Crystallographic description of phases in the Y-Ba-Cu-O superconductor. PMID- 9941014 TI - Room-temperature structure of the 90-K bulk superconductor YBa2Cu3O8-x. PMID- 9941013 TI - Superconductivity above 90 K in the compound YBa2Cu3Ox: Structural, transport, and magnetic properties. PMID- 9941016 TI - Evidence of conventional superconductivity in La-Ba-Cu-O compounds. PMID- 9941015 TI - Upper critical fields of high-Tc superconducting Y2-xBax PMID- 9941017 TI - Effect of quasiparticle tunneling on quantum-phase fluctuations and the onset of superconductivity in granular films. PMID- 9941018 TI - Fermi surface of UPt3 within the local-density approximation. PMID- 9941020 TI - Replica symmetry breaking in random-field systems. PMID- 9941019 TI - Anelastic relaxation due to the tunneling of trapped D in Ta. PMID- 9941021 TI - Spectroscopy of glassy systems with a relaxation-time distribution: Application to Brillouin scattering on Rb0.65(NH4)0.35H2PO4. PMID- 9941022 TI - Ionic and electronic contributions to the Li chemical potential in LixRuzMo6 zSe8. PMID- 9941023 TI - Magnetic structure observed in an applied field in reentrant Au0.81Fe PMID- 9941024 TI - Characteristic pore sizes and transport in porous media. PMID- 9941025 TI - Magnetic phase transitions close to the bicritical concentration in EuSySe1-y. PMID- 9941027 TI - Modulated magnetic properties in synthetic rare-earth Gd-Y superlattices. PMID- 9941026 TI - Phase transitions of Josephson-tunnel-junction arrays at zero and full frustration. PMID- 9941028 TI - Stretched-exponential nuclear magnetization recovery in the proton pseudo-spin glass Rb1-x(NH4)xH2AsO4. PMID- 9941029 TI - Critical wetting in the presence of power-law surface fields. PMID- 9941030 TI - Properties of a spin-1 system with competing interactions and reentrant magnetic behavior. PMID- 9941032 TI - Helicon-wave propagation in a periodic structure. PMID- 9941031 TI - Self-consistent calculation of the eigenfrequencies for the electronic excitations in small jellium spheres. PMID- 9941033 TI - Aharonov-Bohm effect and weak localization in cylindrical Ag films. PMID- 9941034 TI - Numerical simulation of the dense random packing of a binary mixture of hard spheres: Amorphous metals. PMID- 9941035 TI - Image potential for a tunneling electron. PMID- 9941036 TI - Analytical calculation of stopping power for isolated small spheres. PMID- 9941037 TI - Influence of the pseudopotential on the properties of liquid rubidium at 315 K. PMID- 9941039 TI - Enhanced Raman scattering with one monolayer of silver. PMID- 9941038 TI - Fast-ion-induced erosion of leucine as a function of the electronic stopping power. PMID- 9941040 TI - Analytical models for positron annihilation at a vacancy in metals. PMID- 9941042 TI - Tight-binding analysis of the electronic structure of the Al(110) surface. PMID- 9941041 TI - Many-electron effects in x-ray photoelectron spectroscopy as a diagnostic tool for metallic glasses. PMID- 9941043 TI - Density-functional approach to second-harmonic generation at metal surfaces. PMID- 9941044 TI - Atom profiles of interfaces with polar-angle-dependent photoemission: Au/GaAs(100). PMID- 9941045 TI - Interatomic interactions in the effective-medium theory. PMID- 9941047 TI - Bonding or antibonding position of hydrogen in silicon. PMID- 9941046 TI - Magnetoplasmons in a two-dimensional electron gas: Strip geometry. PMID- 9941048 TI - Model dielectric constants of GaP, GaAs, GaSb, InP, InAs, and InSb. PMID- 9941049 TI - Theoretical and experimental investigation of the effective g factor of donor bound electrons in InSb. PMID- 9941050 TI - Small-oscillation theory of the one-dimensional large optic polaron. PMID- 9941051 TI - Spin-orbit coupling in superlattices. PMID- 9941052 TI - Screened potential for planar charged sheets within a semi-infinite Landau quantized plasma. PMID- 9941053 TI - Electronic structures of GeSe2 in crystalline, amorphous, and Ag-photodoped amorphous phases studied by photoemission and optical spectra. PMID- 9941054 TI - Photoionization cross section of the DX center in Si-doped AlxGa1-xAs. PMID- 9941055 TI - Divacancy production in low-temperature electron-irradiated silicon. PMID- 9941057 TI - Equation of state of InP to 19 GPa. PMID- 9941056 TI - Effect of picosecond-laser-driven shock waves on spontaneous and stimulated emissions in GaSe. PMID- 9941058 TI - Photoemission study of bonding at the CaF2-on-Si(111) interface. PMID- 9941059 TI - Interplay of disorder and electron-phonon coupling in models of polyacetylene. PMID- 9941060 TI - Many-body aspects of the optical spectra of bulk and low-dimensional doped semiconductors. PMID- 9941062 TI - Pressure dependence of impurity levels in semiconductors: The deep gold acceptor level and shallow donor and acceptor levels in silicon. PMID- 9941061 TI - Spin dephasing in disordered semiconductors and metals. PMID- 9941063 TI - Exciton binding energy in a quantum well with inclusion of valence-band coupling and nonparabolicity. PMID- 9941064 TI - High-frequency conductivity of superlattices with electron-phonon coupling. PMID- 9941065 TI - High-pressure phases of III-V zinc-blende semiconductors. PMID- 9941067 TI - Hopping conduction and luminescence relaxation due to donor-acceptor pairs. PMID- 9941066 TI - a-Si thin-film growth by sputtering: A Monte Carlo study. PMID- 9941069 TI - Thermal conductivity of a single polymer chain. PMID- 9941068 TI - Theoretical total-energy study of the transformation of graphite into hexagonal diamond. PMID- 9941070 TI - Optical properties and formation of oxygen-perturbed F2 + color center in NaCl. PMID- 9941071 TI - Thermodynamical behavior of the E' center in the optical-fiber drawing process. PMID- 9941072 TI - Exciton luminescence and polariton effects in alkali iodide crystals. PMID- 9941073 TI - La 4d-->4f resonance absorption in LaF3: Temperature dependence. PMID- 9941074 TI - Conduction-band structure of graphite studied by combined angle-resolved inverse photoemission and target current spectroscopy. PMID- 9941075 TI - Electronic structure of alumina and ruby. PMID- 9941077 TI - ir absorption of CN- defects in cesium halides rotationally aligned by alkali metal-ion impurities. PMID- 9941076 TI - Conduction noise in the charge-density-wave compound K0.3MoO3 at low temperatures. PMID- 9941078 TI - c-axis interaction and conductivity of a stage-2 SbCl5-graphite compound. PMID- 9941079 TI - Functional integral for the molecular polaron with q2 coupling: First-loop correction. PMID- 9941080 TI - Self-energy of image states. PMID- 9941081 TI - Optical absorption by aggregates of small particles. PMID- 9941082 TI - Analytical model for the neutralization probability in slow ion-surface collisions. PMID- 9941083 TI - Optical-phonon effects on the elastic constants of PdHx and PdDx. PMID- 9941084 TI - Inverse-photoemission observation of the shape resonance. PMID- 9941085 TI - Dynamic orbital forces and molecular geometry in the density-functional formalism. PMID- 9941086 TI - Electron-phonon interaction effects in a quasi-two-dimensional electron gas in the GaAs-Ga1-xAlxAs heterostructure. PMID- 9941087 TI - Theoretical calculation for a ZnSe-Ge(110) heterojunction with an ultrathin intralayer. PMID- 9941089 TI - g factor of electrons in an InAs quantum well. PMID- 9941088 TI - Hot-electron relaxation in quantum-well structures: Multisubband occupation. PMID- 9941090 TI - Optical absorption from polarons in a diatomic polymer. PMID- 9941091 TI - Erratum: Theory of classical diffusion jumps in solids PMID- 9941092 TI - Observation of dislocationlike images in large-grain quasicrystals of Li-Cu-Al. PMID- 9941094 TI - Mixing in charge-density-wave conductors. PMID- 9941093 TI - Evolution of adsorbate core-hole states after bound and continuum primary excitation: Relaxation versus decay. PMID- 9941096 TI - Comparison of neutral to ionic photodesorption in the valence region: CO/Ru(001). PMID- 9941095 TI - Energetics of charged small metal particles. PMID- 9941097 TI - Quantitative multiple-scattering analysis of near-edge x-ray-absorption fine structure: c(22)O on Cu(100). PMID- 9941098 TI - Spin-resolved angle-dependent photoemission study of ordered Fe3Pt(001) Invar. PMID- 9941099 TI - (11) to (15) surface reconstruction of Ir(001) by pulsed-laser heating: A field ion-microscope study. PMID- 9941100 TI - Steady-state photomodulation spectroscopy of a-Si:H/a-SiNx:H multilayer structures. PMID- 9941102 TI - Proposed use of a scanning-tunneling-microscope tunnel junction for the measurement of a tunneling time. PMID- 9941101 TI - Band nonparabolicity effects in semiconductor quantum wells. PMID- 9941103 TI - Light-induced defect creation in hydrogenated amorphous silicon: A detailed examination using junction-capacitance methods. PMID- 9941104 TI - Below-gap excitation spectroscopy of optically induced paramagnetic states in vitreous As2S PMID- 9941106 TI - Finite-temperature transition for the fractional quantized Hall effect. PMID- 9941105 TI - Transitions to confined states of the split-off band in GaAs-(Al,Ga)As multiple quantum-well heterostructures. PMID- 9941107 TI - Theory and observation of highly asymmetric atomic structure in scanning tunneling-microscopy images of graphite. PMID- 9941108 TI - Core-exciton-induced desorption from MgO. PMID- 9941109 TI - Surface waves in Au/Cr superlattices. PMID- 9941111 TI - Theory of helium diffraction from copper surfaces. PMID- 9941110 TI - Adsorption on stepped surfaces: The adsorbate concentration profile and its induced work-function change. PMID- 9941112 TI - Solid-state properties of one-dimensional metals based on bis(oxalato)platinate anions with divalent cations. PMID- 9941113 TI - Local-space approximation for treatment of chemisorption: Application to a model transition-metal system. PMID- 9941114 TI - Frequency-dependent current density in thin metallic films. PMID- 9941115 TI - Surface-sandwich segregation and multilayer relaxation on Pt0.5Ni0.5(110) measured by low-energy electron diffraction: An observation of face-related segregation reversal. PMID- 9941116 TI - Three states of a polaron on the surface of a liquid-helium film in a uniform magnetic field. PMID- 9941117 TI - Electron density-functional theory and x-ray structure factors. PMID- 9941119 TI - Evaluation of some effective-medium theories for liquid and amorphous metals. PMID- 9941118 TI - Angle-resolved photoemission study of the (100) surface of a ZrN0.93 single crystal. PMID- 9941120 TI - Influence of preparation technique on the electrical conductivity of Ag2HgI4. PMID- 9941121 TI - Ion-beam-induced epitaxial vapor-phase growth: A molecular-dynamics study. PMID- 9941122 TI - Effect of spin-orbit coupling on the conduction-electron Zeeman splitting in platinum-group metals. PMID- 9941123 TI - Valence-level photoemission spectra of the actinide intermetallic compounds ThPt3, UPt5, UAu3, and USn3. PMID- 9941124 TI - Photoemission study of the Al-Sb(111) interface. PMID- 9941125 TI - de Haas-van Alphen effect in MoSi2. PMID- 9941126 TI - Determination of the incommensurately modulated structure of alpha -uranium below 37 K. PMID- 9941127 TI - Step profiles predicted with the modified point-ion model for eight face-centered and body-centered-cubic surfaces. PMID- 9941128 TI - Macroscopic physics of the silicon inversion layer. PMID- 9941130 TI - Drift-velocity saturation of holes in anthracene at room temperature. PMID- 9941129 TI - Raman-scattering study of the high-pressure phase transition in Cd1-xMnxTe. PMID- 9941131 TI - Effect of valence dielectric screening on ionized-impurity-scattering-limited mobility in GaAs. PMID- 9941132 TI - Charge-density-wave states in the fractional quantum Hall regime. PMID- 9941133 TI - Conductivity relaxation time due to electron-hole collisions in optically excited semiconductors. PMID- 9941135 TI - NN2 trap in GaP: A reexamination. PMID- 9941134 TI - Midgap injection-induced absorption in amorphous silicon. PMID- 9941136 TI - Interpretation of experiments implying density of states between Landau levels of a two-dimensional electron gas by a statistical model for inhomogeneities. PMID- 9941138 TI - Pressure dependence of the permittivity of trigonal Se and Te. PMID- 9941137 TI - Comparative high-resolution electron-energy-loss spectroscopy study of hydrogen adsorption on GaAs and InP (111) and (1-bar 1-bar 1-bar) surfaces. PMID- 9941140 TI - Resonant Raman scattering by LO phonons in AlxGa1-xAs (x < 0.1): Alloying and interference effects. PMID- 9941139 TI - Optical reflectivity spectra of the mixed-stack organic charge-transfer crystal tetrathiafulvalene-p-chloranil under hydrostatic pressure. PMID- 9941141 TI - Direct calculation of interfacial energetics: Roles of axial commensuration and strain in epitaxial growth. PMID- 9941143 TI - Inter-quantum-well diffusion in semiconductor superlattices. PMID- 9941142 TI - Surface structure of Ge(100) studied by He diffraction. PMID- 9941145 TI - Tetrahedron model for the dielectric function of amorphous silicon-carbon alloys. PMID- 9941144 TI - Establishment of an effective-mass Hamiltonian for abrupt heterojunctions. PMID- 9941146 TI - Optical constants of a series of amorphous hydrogenated silicon-carbon alloy films: Dependence of optical response on film microstructure and evidence for homogeneous chemical ordering. PMID- 9941148 TI - Theory of the linear and nonlinear optical properties of semiconductor microcrystallites. PMID- 9941147 TI - One-dimensional exciton diffusion in a conjugated polymer. PMID- 9941150 TI - Classical description of laser-induced desorption rates. PMID- 9941149 TI - Simple model for resonant tunneling beyond the effective-mass approximation. PMID- 9941151 TI - Variational calculation of polarization of quantum-well photoluminescence. PMID- 9941153 TI - Kinetics of high-density plasmas generated in Si by 1.06- and 0.53- microm picosecond laser pulses. PMID- 9941152 TI - Theoretical study of band offsets at semiconductor interfaces. PMID- 9941155 TI - Photoemission surface core-level study of sulfur adsorption on Ge(100). PMID- 9941154 TI - Self-consistent linear-combination-of-Gaussian-orbitals approach for polymers: Application to trans-(CH)x. PMID- 9941156 TI - Theory of infrared absorption in silicon. PMID- 9941157 TI - Ab initio pseudopotential study of structural and high-pressure properties of SiC. PMID- 9941158 TI - Deuteron diffusion and photoluminescence in lithium-doped MgO crystals. PMID- 9941159 TI - Structural and electronic properties of graphite via an all-electron total-energy local-density approach. PMID- 9941160 TI - Dynamics and electronic properties of the Tl+-perturbed Tl0(1) center in KCl, KBr, and RbCl as probed by resonant Raman scattering. PMID- 9941161 TI - Oxygen vacancy and the E1' center in crystalline SiO2. PMID- 9941162 TI - Pressure-temperature phase diagrams of stage-2-4 potassium-graphite intercalation compounds deduced from anomalies in the basal-plane resistivity. PMID- 9941163 TI - Calculated normal photoemission from an unrelaxed NiAl(110) surface. PMID- 9941164 TI - Electronic structure of cubic sodium tungsten bronze. PMID- 9941165 TI - Inelastic proton-solid collisions. PMID- 9941166 TI - Positron diffusion in Mo: The role of epithermal positrons. PMID- 9941167 TI - Classical transport within the scattering formalism. PMID- 9941168 TI - Lattice vibrations in ternary II-VI compounds. PMID- 9941169 TI - Long-range interaction of a helium atom with intercalated graphite. PMID- 9941170 TI - Symmetry and rotational epitaxy of incommensurate Xe layers on Pt(111). PMID- 9941171 TI - Evidence for a critical composition in group-IV-VI chalcogenide glasses. PMID- 9941172 TI - Nonequilibrium cooling of thermalized electrons and holes in GaAs/AlxGa1-xAs quantum wells. PMID- 9941173 TI - Anomalous confinement effects in HgTe-CdTe superlattices. PMID- 9941174 TI - Giant oscillator strength of free excitons in GaAs. PMID- 9941175 TI - Yield of photofield emitted electrons from tungsten. PMID- 9941176 TI - Compositional dependence of radiation damage in ion-irradiated amorphous Ni-B. PMID- 9941177 TI - High-pressure Raman study of the vibrational modes in AlPO4 and SiO2 ( alpha quartz). PMID- 9941178 TI - Effect of magnetic order on the fluorescence dynamics of TbF3. PMID- 9941179 TI - Charge transfer in secondary-ion emission: Tight-binding studies in Si and Si:O clusters. PMID- 9941180 TI - Spectroscopic studies of excited Tm3+ ions in alkaline-earth fluorides. PMID- 9941181 TI - Auger neutralization spectroscopy of clean and adsorbate-covered transition-metal surfaces by deexcitation of metastable noble-gas atoms. PMID- 9941182 TI - Quantum theory of positronium formation at surfaces. PMID- 9941183 TI - Electron-spin-resonance studies of pristine and heavily doped polyacenic materials. PMID- 9941184 TI - Fluorescent emission spectra of lithium fluoride with use of synchrotron radiation. PMID- 9941185 TI - Electric-field-gradient tensor for cadmium impurities in alpha -gallium. PMID- 9941186 TI - Electric-field-gradient tensor orientation for As and Ge atoms in alpha -gallium. PMID- 9941187 TI - Landau parameters of almost-localized Fermi liquids. PMID- 9941188 TI - Superconducting phase boundary of aperiodic networks in a magnetic field. PMID- 9941189 TI - Weak localization in superconductors: A study of radiation-damaged Nb3Ir. PMID- 9941190 TI - Magnetic-field penetration depth and material parameters of V-Ag multilayered superconductors. PMID- 9941192 TI - Momentum-dependent scattering-amplitude model for liquid 3He. PMID- 9941191 TI - Magnetic studies of strontium lanthanum copper oxides. PMID- 9941194 TI - Comparison of the critical magnetic scattering from the Heisenberg system EuO with renormalization-group theory. PMID- 9941193 TI - Theory of ultrasonic attenuation in impure anisotropic p-wave superconductors. PMID- 9941195 TI - EuxSr1-xTe: Spin-glass behavior in a diluted antiferromagnet. PMID- 9941196 TI - Thermodynamics of field-induced spin-density-wave states in Bechgaard salts. III. PMID- 9941197 TI - Mean-field theory of local freezing in the Ising model. PMID- 9941198 TI - Simulation of normal Rb2ZnCl4 near the incommensurate transition. PMID- 9941199 TI - Spin and charge correlations around an Anderson magnetic impurity. PMID- 9941200 TI - Symmetry, phase transition, and polymer limit n=0. PMID- 9941201 TI - Isotope effect on BaTiO3 ferroelectric phase transitions. PMID- 9941202 TI - Classification of octahedral tilting phases in the perovskitelike A2BX4 structure. PMID- 9941203 TI - Dynamical scaling in the Q-state Potts model. PMID- 9941204 TI - Competition between the Kondo effect and exchange interactions in the system CeSix. PMID- 9941205 TI - Numerical simulation of dynamics in the XY model. PMID- 9941207 TI - Dynamics of strongly coupled model rotational-translational systems. PMID- 9941206 TI - Ground-state properties and neutral-to-ionic transformation of organic mixed stack compounds: Mean-field approximation. PMID- 9941208 TI - Ground-state properties of Heisenberg spin chains. PMID- 9941209 TI - Concentration fluctuations of polystyrene-polybutadiene blends. PMID- 9941210 TI - Anomalous diffusion and low-temperature spin-glass susceptibility. PMID- 9941211 TI - Site percolation on central-force elastic networks. PMID- 9941212 TI - Development of long-range order in Hg3- delta AsF6 and Hg3- delta SbF6. PMID- 9941214 TI - Magnetostriction of Ce in CexLa1-xAl2. PMID- 9941213 TI - Effects of defects on the incommensurate phase of sodium nitrite crystals. PMID- 9941216 TI - Linear elasticity theory of pentagonal quasicrystals. PMID- 9941215 TI - Exact solutions for perpendicular susceptibilities of kagome and decorated-kagome Ising models. PMID- 9941217 TI - Effects of edge pinning on the melting transition of a two-dimensional solid. PMID- 9941218 TI - Magnetic properties of iron-rich Fe-Zr glasses. PMID- 9941219 TI - Relation between the classical resistance of inhomogeneous networks and diffusion. PMID- 9941220 TI - Random and nonrandom anisotropy-induced crossover in vector spin glasses. PMID- 9941221 TI - Topological disorder hierarchically trapped at frustration sites: Physical picture for a glass. PMID- 9941222 TI - Nonlinear wave propagation in periodic systems: The driven sine-Toda chain. PMID- 9941223 TI - Crystal-field effects in the high-field magnetization of polycrystalline PrNi5. PMID- 9941224 TI - High-field magnetization of polycrystalline praseodymium. PMID- 9941226 TI - Critical behavior and metastability of the magnetization in the random-field Ising system Fe PMID- 9941225 TI - Molecular-dynamics simulation of a model with incommensurate phases. PMID- 9941227 TI - Influence of damping in an electron gas on vicinage effects in ion-cluster energy loss. PMID- 9941228 TI - Superconductivity of the single-phase compound Er1Ba2Cu3O9- delta : Transport and structural properties. PMID- 9941229 TI - Pressure dependence of the superconducting transition temperature in the 94-K superconductor YBa2Cu3O7. PMID- 9941230 TI - Tunneling spectroscopy of a La-Sr-Cu-O break junction: Evidence for strong coupling superconductivity. PMID- 9941232 TI - Critical temperatures of superconductors with low dimensionality. PMID- 9941231 TI - Electronic structure of Eu in the high-Tc superconductor Ba2EuCu PMID- 9941234 TI - Numerical simulation of the resonant valence-bond state. PMID- 9941233 TI - 1e and 2e superconductivity in spin liquids and spin crystals. PMID- 9941235 TI - Antiferromagnetic singlet pairs, high-frequency phonons, and superconductivity. PMID- 9941236 TI - Superconductivity in A15 compounds under nonhydrostatic stress. PMID- 9941237 TI - Symmetry considerations and physical properties of the order parameter of the 3He A-B interface. PMID- 9941238 TI - Weak localization in short wires: Influence of boundary conditions. PMID- 9941239 TI - Ni participation in the magnetism of Fe-Ni-Si-B amorphous alloys. PMID- 9941241 TI - Calorimetric and dilatometric study of the Curie transition in holmium. PMID- 9941240 TI - Potts glass on the Bethe lattice. PMID- 9941242 TI - Scher and Zallen criterion: Applicability to composite systems. PMID- 9941244 TI - Electrons bound on a liquid-helium surface in the presence of a laser field. PMID- 9941243 TI - Comment on "Carrier-concentration dependence of critical superconducting current induced by the proximity effect in silicon" PMID- 9941245 TI - Positron deformation potential and the temperature dependence of the electron and positron work functions. PMID- 9941246 TI - Nonuniqueness of the state of amorphous pure iron. PMID- 9941247 TI - Antiphase domain boundaries in the superconducting phase of the Y-Ba-Cu-O system. PMID- 9941248 TI - Oxygen ordering in the crystal structure of the 93-K superconductor YBa2Cu3O7 using powder neutron diffraction at 298 and 79.5 K. PMID- 9941249 TI - Effect of compositional variation and annealing in oxygen on superconducting properties of Y1Ba PMID- 9941250 TI - Neutron study of the crystal structure and vacancy distribution in the superconductor Ba2YCu PMID- 9941251 TI - Effect of transition-metal elements on the superconductivity of Y-Ba-Cu-O. PMID- 9941252 TI - Elasticity studies of La2-xSrxCuO4. PMID- 9941253 TI - Ultrasound studies of the high-Tc superconductor La1.85Sr0.15CuO4. PMID- 9941254 TI - Meissner effect in Y-Ba-Cu-O and La-Sr-Cu-O high-temperature superconductors. PMID- 9941255 TI - Thermoelectric power of some high-Tc oxides. PMID- 9941256 TI - Weak-field magnetization of superconducting Y1Ba2Cu3Ox: Relationship to microstructure. PMID- 9941257 TI - Transport properties of the superconducting oxide La1.85Sr0.15CuO4. PMID- 9941259 TI - Hall effect of La2-xSrxCuO4: Implications for the electronic structure in the normal state. PMID- 9941258 TI - Electronic structure of the high-Tc superconductor Sr0.2La1.8CuO4. PMID- 9941260 TI - Photoemission studies of the high-Tc superconductor Ba2YCu3O9- delta. PMID- 9941261 TI - Spectroscopic evidence for strongly correlated electronic states in La-Sr-Cu and Y-Ba-Cu oxides. PMID- 9941262 TI - Resonant photoemission study of superconducting Y-Ba-Cu-O. PMID- 9941263 TI - Thin superconducting oxide films. PMID- 9941264 TI - Superconductivity in (La0.9Sr PMID- 9941265 TI - Surface impedance measurements in La1.8Ba PMID- 9941266 TI - Far-infrared measurement of alpha 2( omega )F( omega ) in superconducting La1.84Sr PMID- 9941267 TI - Phonon density of states in La PMID- 9941268 TI - Phonon dispersion curves for La1.85Sr0.15CuO4. PMID- 9941269 TI - Phonon Raman scattering in superconducting La1.85Sr PMID- 9941271 TI - Tunneling and infrared measurements of the energy gap in the high-critical temperature superconductor Y-Ba-Cu-O. PMID- 9941270 TI - Far-infrared measurement of the gap of the high-Tc superconductor La1.85Sr PMID- 9941272 TI - Point-contact electron tunneling into the high-Tc superconductor Y-Ba-Cu-O. PMID- 9941273 TI - Tunneling measurement of the energy gap in Y-Ba-Cu-O. PMID- 9941274 TI - Break-junction tunneling measurements of the high-Tc superconductor Y1Ba2Cu3O9- delta. PMID- 9941276 TI - Optic breathing mode, resonant charge fluctuations, and high-Tc superconductivity in the layered perovskites. PMID- 9941275 TI - Macroscopic quantum phenomena in high-Tc superconducting material. PMID- 9941277 TI - Topology of the resonating valence-bond state: Solitons and high-Tc superconductivity. PMID- 9941278 TI - Plasmons and high-temperature superconductivity in alloys of copper oxides. PMID- 9941279 TI - Tunneling spectroscopy of the heavy-fermion superconductor CeCu PMID- 9941280 TI - Dipole-dipole interactions and the critical resistivity of gadolinium. PMID- 9941281 TI - Magnetic phase transitions in EuNi5P3: Unusual steps in the magnetization with field. PMID- 9941282 TI - Transmission-electron-microscopy observation of the memory effect through the pattern of discommensurations in barium sodium niobate. PMID- 9941283 TI - Chaos in spin glasses: A renormalization-group study. PMID- 9941284 TI - Effect of pressure on the electrical resistance of EuO. PMID- 9941286 TI - Intersection of two fractal objects: Useful method of estimating the fractal dimension. PMID- 9941285 TI - Coherent backscattering of neutrons. PMID- 9941287 TI - Surface-plasmon-enhanced Brillouin scattering on silver films: Double-resonance effect. PMID- 9941288 TI - Stark-ladder resonances in ordered and disordered electrified chains. PMID- 9941289 TI - Photoemission study of valence fluctuation in YbCu2. PMID- 9941291 TI - Longitudinal magnetoresistance of potassium. PMID- 9941290 TI - Electronically stimulated desorption from physisorbed layers on metal surfaces: Kinetic-energy distributions of desorbed neutral atoms. PMID- 9941292 TI - Transport properties of random and nonrandom substitutionally disordered alloys. I. Exact numerical calculation of the ac conductivity. PMID- 9941293 TI - Transport properties of random and nonrandom substitutionally disordered alloys. II. New cluster formulation of the ac conductivity and numerical applications. PMID- 9941294 TI - Scaling behavior and surface-plasmon modes in metal-insulator composites. PMID- 9941296 TI - Tight-binding coherent-potential-approximation study of the electronic states of palladium-noble-metal alloys. PMID- 9941295 TI - Magnetic-field and polarization dependence of the direct electromagnetic generation of ultrasound in potassium. PMID- 9941297 TI - Density-functional calculation of quadrupolar contributions to the atom-metal van der Waals interaction. PMID- 9941298 TI - Surface-structural analysis by use of spin-polarized low-energy electron diffraction: An investigation of the Cu(100) surface. PMID- 9941299 TI - Localized eigenstates of one-dimensional tight-binding systems: A new algorithm. PMID- 9941300 TI - Development of a three-dimensional valence-band structure in Ag overlayers on Cu(001). PMID- 9941302 TI - Chemical reaction and Schottky-barrier formation at the Ir/Si interface. PMID- 9941301 TI - Electrical conduction in low-resistivity (quasiamorphous) Ag1-xCux alloys. PMID- 9941304 TI - Fundamental difficulty in the use of second-harmonic generation as a strictly surface probe. PMID- 9941305 TI - Quantum theory of the double layer: Model including solvent structure. PMID- 9941303 TI - X-ray diffraction studies of the structure of nanometer-sized crystalline materials. PMID- 9941306 TI - Dispersionless states in random Cayley trees with multiple connectivity. PMID- 9941307 TI - Crystal-field model for acceptor-associated bound magnetic polarons in wurtzite semiconductors. PMID- 9941309 TI - Phase diagram of silicon by molecular dynamics. PMID- 9941308 TI - Folding effects in GaAs-AlAs superlattices. PMID- 9941310 TI - Electron-energy-loss study of the space-charge region at semiconductor surfaces. PMID- 9941312 TI - Nonradiative recombination via deep impurity levels in silicon: Experiment. PMID- 9941311 TI - Role of correlations in (GaSb)1-xGe2x alloys. PMID- 9941314 TI - Effective-mass change of electrons in Si inversion layers under parallel magnetic fields. PMID- 9941313 TI - Far-infrared reflectivity of bis-tetramethyltetraselenafulvalene hexafluoroarsenate PMID- 9941315 TI - Interband critical points of GaAs and their temperature dependence. PMID- 9941316 TI - Analytic relation between bulk moduli and lattice constants. PMID- 9941317 TI - Defect vibrational modes in germanium crystals. PMID- 9941318 TI - Electron-energy-loss rates in AlxGa PMID- 9941319 TI - Optical properties of the 1:2 compound of dimethylferrocenium with tetracyanoquinodimethanide: PMID- 9941320 TI - Benzene adsorption on low-temperature silicon: A synchrotron-radiation photoemission study of valence and core states. PMID- 9941321 TI - Photoluminescence in a-Si1-xGex:H alloys. PMID- 9941322 TI - Exact solution of a transport equation for hot-electron effects in semiconductors and metals. PMID- 9941323 TI - Raman study of phase transitions in ion-implanted and Q-switched neodymium-doped yttrium aluminum garnet laser annealed silicon. PMID- 9941324 TI - Interchain solitonic excitons in trans-polyacetylene. PMID- 9941325 TI - Asymmetry of the transient on-state characteristics of a threshold switching noncrystalline chalcogenide semiconductor. PMID- 9941327 TI - Small-polaron conductivity in magnetite. PMID- 9941326 TI - Determination of transition energies and oscillator strengths in GaAs-AlxGa1-xAs multiple quantum wells using photovoltage-induced photocurrent spectroscopy. PMID- 9941328 TI - Bipolarons in boron-rich icosahedra: Effects of carbon substitution. PMID- 9941329 TI - Static and dynamic contributions to the lowest 4f-->5d two-photon transition in CaF2:Ce3+ PMID- 9941330 TI - Ionic contributions to the Raman tensor of insulators. PMID- 9941332 TI - Strong-perturbation theory for impurities in semiconductors. PMID- 9941331 TI - Structural stabilities of layered materials: Pt-Ta. PMID- 9941333 TI - Localization and the density of states for an electron in a quantized elastic continuum. PMID- 9941334 TI - Interface polariton modes in semiconductor quasiperiodic superlattices. PMID- 9941335 TI - Constant-dipole-matrix-element model for Faraday rotation in amorphous semiconductors. PMID- 9941336 TI - Cyclotron-resonance linewidth due to electron-phonon interaction in multi-quantum well structures. PMID- 9941337 TI - Specific heat of deoxyribonucleic acid at temperatures below 5 K. PMID- 9941339 TI - Erratum: Invariant-imbedding approach to resistance fluctuations in disordered one-dimensional conductors PMID- 9941338 TI - Erratum: Electron charge densities at conduction-band edges of semiconductors PMID- 9941340 TI - Erratum: Linear and nonlinear electrical conduction in quasi-two-dimensional quantum wells PMID- 9941341 TI - Electronic structure of Cu overlayers on AlN. PMID- 9941342 TI - Self-energy of an electron in a gap between two metals and near a metallic slab. PMID- 9941343 TI - Set of five related photoluminescence defects in silicon formed through nitrogen carbon interactions. PMID- 9941344 TI - Epitaxial growth of a metastable modification of copper with body-centered-cubic structure. PMID- 9941345 TI - New quasicrystals of alloys containing s, p, PMID- 9941347 TI - Search for charge-density waves in a single crystal of potassium. PMID- 9941346 TI - Search for charge-density waves in potassium by neutron diffraction. PMID- 9941348 TI - Effect of layer-thickness fluctuations on superlattice diffraction. PMID- 9941349 TI - Model for a novel metal-restructuring procedure. PMID- 9941350 TI - Exciton binding energy in quantum-well wires. PMID- 9941351 TI - Two-dimensional magnetotransport in AlAs quantum wells. PMID- 9941353 TI - Bremsstrahlung-isochromat studies of conduction-band states in SnS2 and SnSe2. PMID- 9941352 TI - Temperature-dependent reaction and buried-interface movement for Ti/GaAs(100) and Cr/GaAs(100). PMID- 9941355 TI - High-resolution electron-energy-loss study of NH3 adsorption on Si(111)21 at room temperature. PMID- 9941354 TI - Effects of local disorder on donor states in amorphous silicon. PMID- 9941356 TI - Thickness dependence of optical gap and void fraction for sputtered amorphous germanium. PMID- 9941357 TI - Phonon stop bands in amorphous superlattices. PMID- 9941359 TI - Electron-nuclear double-resonance evidence for the soliton wave function in polyacetylene. PMID- 9941358 TI - Si-O bond-length modification in pressure-densified amorphous SiO2. PMID- 9941361 TI - Resonant tunneling in magnetic field: Evidence for space-charge buildup. PMID- 9941360 TI - Site symmetry of the EL2 center in GaAs. PMID- 9941362 TI - Shock launching in silicon studied with use of pulsed x-ray diffraction. PMID- 9941364 TI - Novel electronic structure of the hydrogen-potassium-graphite ternary intercalation compounds. PMID- 9941363 TI - Photoemission spectroscopy of ultrathin hydrogenated amorphous silicon layers. PMID- 9941365 TI - Barrier to oxygen penetration on metal and oxide surfaces. PMID- 9941367 TI - Inverse-photoemission studies of adsorbed diatomic molecules. PMID- 9941366 TI - Luminescence of fused silica: Observation of the O2- emission band. PMID- 9941368 TI - Systematic ab initio configuration-interaction study of alkali-metal clusters: Relation between electronic structure and geometry of small Li clusters. PMID- 9941369 TI - Electron-energy-loss study of clean and oxygen-exposed polycrystalline zirconium. PMID- 9941370 TI - Direct-space analysis of the Hartree-Fock energy bands and density of states for metallic extended systems. PMID- 9941371 TI - Size dependence of surface cluster models: CO adsorbed on Cu(100). PMID- 9941372 TI - Thermodynamics of copper and nickel: Band-structure effects and their disappearance at high temperatures. PMID- 9941373 TI - Anisotropic surface-enhanced Raman scattering at obliquely evaporated Ag films. PMID- 9941374 TI - Adsorbate densities and surface potentials of physisorbed systems: A density functional approach. PMID- 9941375 TI - Lattice dynamics of p4g c(22) structures: An application to reconstructed Ni(100). PMID- 9941376 TI - Phonon dispersion of the (22) phase of carbon on the reconstructed Ni(100) surface. PMID- 9941378 TI - Critical electronic wave functions on quasiperiodic lattices: Exact calculation of fractal measures. PMID- 9941377 TI - Thermal desorption of interacting molecules from heterogeneous surfaces. PMID- 9941379 TI - Incoherent tunneling in a double well. PMID- 9941380 TI - Molecular-dynamics study of self-interstitials in silicon. PMID- 9941381 TI - Stability and electronic properties of complex structures of silicon and carbon under pressure: Density-functional calculations. PMID- 9941382 TI - Exchange and correlation effects on the quasiparticle band structure of semiconductors. PMID- 9941383 TI - Exchange reaction, clustering, and surface segregation at the Al/InSb(110) interface. PMID- 9941385 TI - Zone folding and subband dispersions in GaAs-AlxGa1-xAs(001) superlattices. PMID- 9941384 TI - Transport properties of bismuth sulfide single crystals. PMID- 9941386 TI - Electronic structure of some beta -(C10H8S8)2X compounds as studied by infrared spectroscopy. PMID- 9941387 TI - Electron-electron correlations in one-dimensional conjugated polymers. PMID- 9941388 TI - Resonant Raman scattering by LO phonons near the E0+ Delta 0 gap of GaSb. PMID- 9941389 TI - Ab initio theory of polar semiconductor surfaces. I. Methodology and the (22) reconstructions of GaAs(111). PMID- 9941390 TI - Ab initio theory of polar semiconductor surfaces. II. (22) reconstructions and related phase transitions of GaAs(1-bar1-bar1-bar). PMID- 9941391 TI - Quantum transport for Bloch electrons in a spatially homogeneous electric field. PMID- 9941392 TI - LO-phonon oscillations and electron freeze-out in transport through In-InP and Sn InP contacts. PMID- 9941393 TI - Simple model for structural properties and crystal stability of sp-bonded solids. PMID- 9941394 TI - Electronic structure, defect states, and optical absorption of amorphous Si1-xNx PMID- 9941395 TI - Strain-induced confinement in Si0.75Ge0.25 (Si/Si0.5Ge0.5) (001) superlattice systems. PMID- 9941396 TI - Dielectric function of polyacetylene. PMID- 9941397 TI - Magneto-optics of semiconductors with double-hump and nonparabolic band structures. PMID- 9941398 TI - Nonequilibrium current fluctuations in semiconductors: A Boltzmann-equation-Green function approach. PMID- 9941399 TI - Thermally and optically induced metastabilities in doped hydrogenated amorphous silicon: ESR studies. PMID- 9941401 TI - Electron states in n-type inversion layers with periodic microstructure. PMID- 9941400 TI - Nonperturbative balance equations for the nonequilibrium electron-phonon-impurity system in an applied high electric field. PMID- 9941402 TI - Effects of alloy disorder on Schottky-barrier heights. PMID- 9941403 TI - Delta J=4 infrared transitions of solid D2 and a Raman study of H2, D2, and HD in their liquid and solid phases. PMID- 9941404 TI - Computer simulation of translational and rotational dynamics in LiKSO4. PMID- 9941405 TI - Acoustic radiation-induced static strains in solids. PMID- 9941406 TI - Radiation-sensitivity enhancement and annealing variation in densified, amorphous SiO2. PMID- 9941407 TI - Comparative optical study of the two-dimensional donor-type intercalation compounds graphite-KHx and their binary counterparts C8K and C24K. PMID- 9941408 TI - Identification of satellites due to resonant excitation and shake-off in the C KVV Auger line shape of polyethylene. PMID- 9941409 TI - Differential conductance in three-dimensional resonant tunneling. PMID- 9941410 TI - Susceptibility study of physisorbed oxygen layers on graphite. PMID- 9941411 TI - Exciton in a slab of polar crystal. PMID- 9941412 TI - Theoretical aspects of solid hydrogen halides under pressure. PMID- 9941413 TI - Magnetoplasma modes of semiconductor superlattices with integral Landau-level filling. PMID- 9941414 TI - Revised results for the structural properties of arsenic. PMID- 9941416 TI - rf quantum Hall effect in a superlattice. PMID- 9941415 TI - Integral and fractional quantization of a class of quantum systems. PMID- 9941417 TI - X-ray photoelectron diffraction at high angular resolution. PMID- 9941418 TI - Near-edge x-ray-absorption fine-structure observations of ordering and metalliclike behavior in organic conducting polymers grafted on a Pt surface. PMID- 9941419 TI - Electronic states and quantum Hall effect in GaSb-InAs-GaSb quantum wells. PMID- 9941420 TI - Interface phenomena at semiconductor heterojunctions: Local-density valence-band offset in GaAs/AlAs. PMID- 9941421 TI - Calculated transport properties of ultrasubmicrometer quasi-one-dimensional inversion lines. PMID- 9941422 TI - Structure of Al-Mn-Cr-Si quasicrystals studied by pulsed neutron scattering. PMID- 9941424 TI - Generating functional for electron-phonon systems from functional integrals with one-sided boundary conditions. PMID- 9941423 TI - Scattering of helium from O/Ni(001): Cluster-model studies. PMID- 9941425 TI - Microscopic theory of electrodynamic response of diffuse jellium surfaces. PMID- 9941426 TI - Fokker-Planck equation for physisorption kinetics: General formulation for isothermal desorption. PMID- 9941427 TI - Hole-induced shakedown process in the M4,5 fluorescent emission spectrum of lanthanum. PMID- 9941428 TI - Electron mean-free-path calculations using a model dielectric function. PMID- 9941429 TI - Estimates of the heats of adsorption for Pt and Pd monolayers on Ta(110). PMID- 9941430 TI - Vibrational spectroscopy of fluid N2 up to 34 GPa and 4400 K. PMID- 9941431 TI - Dynamic pseudopotential theory of phonon spectra in metals. PMID- 9941432 TI - Dynamic pseudopotential theory of phonons in twelve cubic metals. PMID- 9941433 TI - Linear augmented Slater-type-orbital study of Au-5d-transition-metal alloying. PMID- 9941435 TI - Optical response of a nonlinear dielectric film. PMID- 9941434 TI - Experimental determination of the Pd and Cu densities of states in Cu75Pd25. PMID- 9941436 TI - Light quantum particles in a metallic environment. PMID- 9941437 TI - Localization and electron-electron interaction effects in thin Au-Pd films and wires. PMID- 9941439 TI - 1/f gamma noise from single-energy-level defects. PMID- 9941438 TI - Close-packed (polytypic) structures in molecular-dynamics simulations. PMID- 9941440 TI - Sodium atom on copper clusters. PMID- 9941441 TI - Dynamic polarizability of small metal particles. PMID- 9941442 TI - Generalized set of elastic moduli and stability of deformed cubic crystals. PMID- 9941443 TI - Analytical determination of the density-of-gap-states distribution in amorphous semiconductors: Experimental results. PMID- 9941445 TI - Polaron and bipolaron excitations in doped polythiophene. PMID- 9941444 TI - Accuracy of various theories of band-gap narrowing in p -doped semiconductors. PMID- 9941447 TI - Thermally induced abrupt shrinking of a donor state in a ferromagnetic semiconductor. PMID- 9941446 TI - Silicide formation at the Ti/Si(111) interface: Diffusion parameters and behavior at elevated temperatures. PMID- 9941448 TI - Interband optical transitions in GaAs-Ga1-xAlxAs superlattices in an applied electric field. PMID- 9941449 TI - Electronic structure of the "chain" chalcogenide TlInSe2. PMID- 9941450 TI - Doubly resonant LO-phonon Raman scattering observed with GaAs-AlxGa1-xAs quantum wells. PMID- 9941451 TI - Magnetization and magnetoreflectivity measurements in Zn1-xMnxTe with 0.25 <= x<=0.71. PMID- 9941453 TI - Size effect of parallel silicide contact. PMID- 9941452 TI - Angle-resolved photoemission from step-related surface states on vicinal surfaces of Si(001). PMID- 9941454 TI - Higher excited states of acceptors in cubic semiconductors. PMID- 9941455 TI - Electronic states of BaPb1-xBixO3 in the semiconducting phase investigated by optical measurements. PMID- 9941456 TI - Comparative study of the electronic structure and conduction properties of polypyrrole, polythiophene, and polyfuran and their copolymers. PMID- 9941457 TI - Lattice distortions and vibrational modes of substitutional impurities in silicon. PMID- 9941458 TI - Valence-band structure of alpha -Sn determined by angle-resolved photoemission. PMID- 9941459 TI - Electronic transport properties of a two-dimensional electron gas in a silicon quantum-well structure at low temperature. PMID- 9941460 TI - Solitons in the Peierls condensate. II. Amplitude solitons. PMID- 9941461 TI - New approach to the problem of lattice dynamics of modulated structures: Application to superlattices. PMID- 9941463 TI - Pressure-induced structural instability of cesium halides from ab initio pseudopotential techniques. PMID- 9941462 TI - Electronic structure of CF3 radicals on GaAs(001). PMID- 9941464 TI - Oxygen-diffusion kinetics in densified, amorphous SiO2. PMID- 9941465 TI - Calculation of the FH(OH-)-center absorption bands in CsCl. PMID- 9941466 TI - Time dependence of desorbed ground-state lithium atoms following pulsed-electron beam irradiation of lithium fluoride. PMID- 9941468 TI - Tunneling current through a disordered insulator. PMID- 9941467 TI - Theoretical study of oxygen in silicon: Breaking of the Si-Si bond. PMID- 9941469 TI - Electronic structure of staging dislocations, electron scattering states, and the residual resistance of graphite intercalation compounds. PMID- 9941471 TI - Lattice dynamics of KTa1-xNbx PMID- 9941470 TI - Specific intermediate-valence state of insulating 4f compounds detected by L3 x ray absorption. PMID- 9941473 TI - Model description of the dephasing of optical impurities in glasses. PMID- 9941472 TI - Anisotropy of 39K binding in C8K studied by nuclear resonance photon scattering. PMID- 9941474 TI - Low-temperature structure of a HNO3-graphite intercalated compound: A neutron diffraction study. PMID- 9941475 TI - Symmetry and supersymmetry in crystals. PMID- 9941476 TI - Image-force effects on the barrier height for metal-metal tunneling electrons. PMID- 9941478 TI - Density-density response function in the fractional quantum Hall effect. PMID- 9941477 TI - Memory function and dynamic conductivity of a type-I superlattice in a magnetic field: Hydrodynamic theory of magnetoplasma resonance. PMID- 9941479 TI - Vibrational correlation functions for Si and Ge. PMID- 9941481 TI - Vacancies, dislocations, and carbon interstitials in Si. PMID- 9941480 TI - Surface collective charge-density excitations of a semiconductor superlattice. PMID- 9941482 TI - Relationship between Boussinesq and Cauchy radiation stresses in solids. PMID- 9941483 TI - Erratum: Lattice dynamics of bcc Sr PMID- 9941484 TI - Erratum: Temperature-dependent adsorption of aromatic molecules on silicon PMID- 9941485 TI - Pressure-induced metallization of BaSe. PMID- 9941486 TI - Velocity-dependent isotope fractionation in secondary-ion emission. PMID- 9941487 TI - Simulation of Au(100) reconstruction by use of the embedded-atom method. PMID- 9941488 TI - Brillouin scattering study of lattice-stiffness changes due to ion irradiation: Dramatic softening in Nb3Ir. PMID- 9941489 TI - Adsorbate-substrate vibrational coupling in physisorbed Kr films on Pt(111). PMID- 9941490 TI - Dynamical evidence for a change in hydrogen-diffusion behavior in transition metal hydrides at high temperatures. PMID- 9941492 TI - Hierarchy of current cumulants on a Sierpinski gasket. PMID- 9941491 TI - Mechanism of prebreakdown nonlinear energy deposition from intense photon fields at 532 nm in NaCl. PMID- 9941493 TI - Final-state effects in inverse photoemission from heavy-fermion compounds. PMID- 9941494 TI - Local-environment dependence of the electronic structure of a Penrose lattice. PMID- 9941495 TI - Electronic promoters and semiconductor oxidation: Alkali metals on Si(111) surfaces. PMID- 9941497 TI - Proposed experiment for the observation of surface plasmons in semiconductor superlattices. PMID- 9941496 TI - Two-photon photoemission study of the empty states of InP(100). PMID- 9941498 TI - Electronic and magnetic properties of the fcc Fe(001) thin films: Fe/Cu(001) and Cu/Fe/Cu(001). PMID- 9941499 TI - Generalized Ramsauer-Townsend resonance in angle-resolved photoemission extended fine-structure oscillations. PMID- 9941500 TI - Unoccupied surface states on Ta(100) observed with inverse photoemission. PMID- 9941501 TI - Ultrasonic attenuation and electron mean free path in aluminum from measurements in a high transverse magnetic field. PMID- 9941502 TI - Surface segregation in dilute binary fcc transition-metal alloys. PMID- 9941503 TI - Phase transitions in samarium at high pressures. PMID- 9941504 TI - Binding energy of image-potential states: Dependence on crystal structure and material. PMID- 9941505 TI - Effective mass of image-potential states. PMID- 9941506 TI - Localization and topological disorder. PMID- 9941507 TI - Screened-exchange functional for the uniform-density electron gas. PMID- 9941508 TI - Electronic structure, photoemission, and magnetism in Gd2Co and Er2Co glasses. PMID- 9941509 TI - Sound attenuation by electrons in metals. PMID- 9941510 TI - Critical wave functions and a Cantor-set spectrum of a one-dimensional quasicrystal model. PMID- 9941511 TI - Investigation of surface defects on Ni(110) with a low-energy positron beam. PMID- 9941513 TI - Electron scattering times from weak localization studies of Au-Pd films. PMID- 9941512 TI - Universal conductance fluctuations in metals: Effects of finite temperature, interactions, and magnetic field. PMID- 9941514 TI - Bond weakening by hydrogen in transition metals. PMID- 9941515 TI - Macroscopic approach to the theory of one-dimensional disordered conductors. PMID- 9941516 TI - Effect of plasma waves on the optical properties of metal-insulator superlattices. PMID- 9941517 TI - Critical cluster size for mixed valence in small matrix-isolated Sm clusters. PMID- 9941518 TI - Angle-resolved-photoemission extended-fine-structure spectroscopy investigation of c(2 x 2) S/Ni(011). PMID- 9941519 TI - Transferability and scaling of Slater-Koster parameters in transition metals. PMID- 9941520 TI - Phenomenological theory of optical second- and third-harmonic generation from cubic centrosymmetric crystals. PMID- 9941521 TI - Laser heating of a transparent crystal via adsorbed atoms. PMID- 9941522 TI - Nondirect transitions in variable-temperature angle-resolved photoemission from metals. PMID- 9941523 TI - Relaxation and nonradiative decay in disordered systems. III. Statistical character of Raman (two-quanta) spin-lattice relaxation. PMID- 9941524 TI - High-pressure phase transitions in diamond and zinc-blende semiconductors. PMID- 9941526 TI - Overlayer-cation reaction at the Pt/Hg1-xCdxTe interface. PMID- 9941525 TI - Variation of the electron-phonon mobility with carrier density for highly doped and highly excited semiconductors. PMID- 9941527 TI - Effects of alloying and hydrostatic pressure on electronic and optical properties of GaAs-AlxGa1-xAs superlattices and multiple-quantum-well structures. PMID- 9941529 TI - Nonparabolic behavior of GaSb-AlSb quantum wells under hydrostatic pressure. PMID- 9941528 TI - Fermi surface, effective masses, and energy bands of HfTe5 as derived from the Shubnikov-de Haas effect. PMID- 9941530 TI - Extended x-ray-absorption fine-structure Debye-Waller factors and vibrational density of states in amorphous arsenic. PMID- 9941531 TI - Electronic structure of PMID- 9941532 TI - Evolution of the vibrational spectra of hydrogenated-amorphous-silicon thin films having columnar morphology. PMID- 9941533 TI - Theoretical study of the electronic structure of the incoherent {211} Sigma =3 grain boundary in Ge by the recursion approach. PMID- 9941535 TI - Transient behavior of the second-order optical process in CdxZn1-xTe: Transformation from luminescence into Raman scattering. PMID- 9941534 TI - Transition from dispersive to nondispersive transport: Photoconduction of polyvinylcarbarzole. PMID- 9941537 TI - Theory of the surface acoustic soliton. IV. Superlattices. PMID- 9941538 TI - Theory of photoabsorption in modulation-doped semiconductor quantum wells. PMID- 9941536 TI - Si(111)-7 x 7 surface: Energy-minimization calculation for the dimer-adatom stacking-fault model. PMID- 9941539 TI - Thermal-equilibrium processes in amorphous silicon. PMID- 9941540 TI - Linear and nonlinear electrical conduction in quasi-two-dimensional quantum wells. PMID- 9941541 TI - Stochastic random network model in Ge and Si chalcogenide glasses. PMID- 9941542 TI - Raman phonon piezospectroscopy in GaAs: Infrared measurements. PMID- 9941543 TI - Nonequilibrium phonon effect on time-dependent relaxation of hot electrons in semiconductor heterojunctions. PMID- 9941545 TI - Conduction band of Si-GexSi1-x superlattices using the envelope-function approximation. PMID- 9941544 TI - Dielectric constant of a two-dimensional electron gas with a partially occupied Landau level. PMID- 9941547 TI - Testing shape selection in directional solidification. PMID- 9941546 TI - Conduction-band-edge charge densities in elemental and compound semiconductors. PMID- 9941549 TI - Theory of the orientational glass state in mixed crystals M(CN)xX 1-x. I. Statics. PMID- 9941548 TI - Specific heat and thermal expansion of Li+ ions in KCl: Evidence for the pair density of states. PMID- 9941550 TI - Theory of the orientational glass state in mixed crystals M(CN PMID- 9941551 TI - Melting studies of argon on ZYX graphite. PMID- 9941552 TI - Nitrogen-ion energy loss in Havar, nickel, Kapton, and Mylar foils. PMID- 9941554 TI - Correlation between charge and current corrugations in scanning-tunneling microscopy. PMID- 9941553 TI - Conversion-electron extended x-ray-absorption fine-structure measurements of ion damaged GaAs. PMID- 9941555 TI - Possible interpretation of the photoelectron spectrum for americium metal. PMID- 9941557 TI - Kinetics of the Staebler-Wronski effect. PMID- 9941556 TI - Thermoelectric power of barium up to 8 GPa. PMID- 9941559 TI - Transverse conductance fluctuations and magnetic field asymmetry. PMID- 9941558 TI - Simple method to estimate pressure of narrow full core levels. PMID- 9941560 TI - Formation and destruction of the heavy-electron ground state in U compounds with AuBe5 crystal structure. PMID- 9941561 TI - Two-dimensional Penrose lattice: dc conductivity. PMID- 9941562 TI - Quantized Hall effect in quasi-three-dimensional systems. PMID- 9941563 TI - Ethylene on cleaved silicon: High-resolution electron-energy-loss study of an unusual adsorption system in the temperature range 85-300 K. PMID- 9941565 TI - Nonlinear effects in quasielastic neutron scattering: Exact line-shape calculation for a dimer. PMID- 9941564 TI - Ubiquity of logarithmic scaling, 1/f power spectrum, and the pi /2 rule. PMID- 9941567 TI - Secondary-ion emission from clean and oxidized aluminum as a function of incident ion mass and energy. PMID- 9941566 TI - Secondary-ion emission from vanadium as a function of incident ion mass and energy in the range 25-275 keV. PMID- 9941568 TI - Hyperfine fields and local-moment formation at 3d-series impurities in terbium. PMID- 9941569 TI - Location of antimony in a halophosphate phosphor. PMID- 9941570 TI - Energy-loss probability in electron microscopy. PMID- 9941571 TI - Mossbauer spectrum for diffusing atoms including fluctuating hyperfine interactions. PMID- 9941572 TI - Interaction of metastable noble-gas atoms with transition-metal surfaces: Resonance ionization and Auger neutralization. PMID- 9941573 TI - Temperature dependence of the hyperfine interactions of 111Cd in silicon. PMID- 9941575 TI - Electronic and atomic structure of the boron-vacancy complex in silicon. PMID- 9941574 TI - Vacancy in silicon: Hyperfine interactions from electron-nuclear double resonance measurements. PMID- 9941576 TI - Ion-beam mixing at the Fe/Al2O3 interface as revealed by conversion-electron Mossbauer spectroscopy. PMID- 9941577 TI - Electronic structure, magnetic properties, Mossbauer isomer shifts, and hyperfine fields of disordered Fe-rich Fe-Al alloys. PMID- 9941578 TI - Nuclear spin-lattice relaxation in the randomly diluted magnetic system KNixMg1 xF3. PMID- 9941579 TI - Resonant-photoemission study of Fe(100). PMID- 9941580 TI - Transport properties of a multicomponent Fermi liquid. PMID- 9941581 TI - Variation of the critical order-parameter phase difference with temperature from 0.4 to 1.9 K in the flow of superfluid 4He through a tiny orifice. PMID- 9941582 TI - Theory for dirty superconductors. I. Strong-coupling equations. PMID- 9941583 TI - Theory for dirty superconductors. II. McMillan solution and Tc degradation. PMID- 9941584 TI - Multiple-quantum-flux penetration in a superconducting loop containing a Josephson junction: Temperature dependence. PMID- 9941585 TI - Critical fields of Nb-Ta multilayers. PMID- 9941586 TI - Positional disorder in a Josephson-junction array. PMID- 9941587 TI - Superconducting arrays in a magnetic field: Quantum effects. PMID- 9941588 TI - Simple approximation for the Bethe-ansatz solution of the one-dimensional Fermi gas. PMID- 9941589 TI - Response of Josephson junctions to far-infrared radiation near their plasma resonance frequencies. PMID- 9941591 TI - Critical-temperature enhancement in thin superconducting films due to field dependence of the coherence length. PMID- 9941590 TI - Origins of the attractive interactions for the Cooper pairs in dense Kondo systems. PMID- 9941592 TI - Model Fermi liquid interacting via a hard-core repulsive potential and an attractive tail. PMID- 9941594 TI - Anisotropy of the Fermi surface, Fermi velocity, many-body enhancement, and superconducting energy gap in Nb. PMID- 9941593 TI - Electron density in artificial metallic superlattices. PMID- 9941595 TI - Self-consistent hydrodynamical model for He II near absolute zero in the framework of stochastic mechanics. PMID- 9941596 TI - Many-polaron theory for superconductivity and charge-density waves in a strongly coupled electron-phonon system with quasi-two-dimensionality: An interpolation between the adiabatic limit and the inverse-adiabatic limit. PMID- 9941597 TI - Magnetic phase diagram of disordered Ni-Mn near the multicritical point. PMID- 9941598 TI - Ferro-spin-glass domain model for disordered Ni-Mn. PMID- 9941599 TI - Structure factors associated with the continuous melting of two-dimensional lattice gases: Models with ( sqrt 3 x sqrt 3)R30 degrees and p(2 x 2) ordered states on triangular nets. PMID- 9941600 TI - High-field specific-heat and susceptibility measurements: Relevance to the spin Peierls phase diagram and the validity of a soliton picture. PMID- 9941602 TI - Interfacial structure and kinetics of ordering in weak ferromagnets. PMID- 9941601 TI - Universal scaling form of the correlation length in Ising strips with periodic, free, fixed, and mixed boundary conditions. PMID- 9941604 TI - Effect of long-range forces on wetting near bulk critical temperatures: An Ising model study. PMID- 9941603 TI - Magnetic instability of a highly degenerate Kondo lattice. PMID- 9941605 TI - Relaxation functions, memory functions, and random forces in the one-dimensional spin-1/2 XY and transverse Ising models. PMID- 9941606 TI - Complex-temperature-plane zeros: Scaling theory and multicritical mean-field models. PMID- 9941607 TI - Hyperuniversality and the renormalization group for finite systems. PMID- 9941608 TI - Simulations of the three-dimensional Hubbard model: Half-filled band sector. PMID- 9941609 TI - Magnetic properties of graphite intercalation compounds. PMID- 9941610 TI - Phase diagrams of a disordered, ferromagnetic, binary Ising system. PMID- 9941611 TI - Finite-size scaling in the ground state of spin-1/2 antiferromagnetic XXZ rings. PMID- 9941612 TI - Onset of fractal growth: Statics and dynamics of diffusion-controlled polymerization. PMID- 9941614 TI - Measurement of nonuniversal critical behavior in a two-dimensional continuum percolating system. PMID- 9941613 TI - Polarized neutron studies of forbidden magnons in the two-dimensional ferromagnet K2CuF4. PMID- 9941615 TI - Transport properties and spin disorder in the degenerate ferro-spin-glass Sn1 xMnxTe. PMID- 9941616 TI - Evidence for free-electron-like Stoner excitations in Fe. PMID- 9941617 TI - Strong electronic correlations in a new class of Yb-based compounds: YbXCu4 (X=Ag,Au,Pd). PMID- 9941619 TI - Charge-density waves in the mixed-valence two-dimensional metal K3Cu8S6. PMID- 9941618 TI - Dipole-exchange spin-wave modes in very-thin-film antiferromagnets. PMID- 9941620 TI - Hyperfine-field dependence on temperature and concentration in Au-Fe alloys. PMID- 9941622 TI - Transverse spin susceptibility and nuclear spin-lattice relaxation rate of field induced spin-density waves in Bechgaard salts. PMID- 9941621 TI - Temperature effects on the universal equation of state of solids. PMID- 9941624 TI - Invariant geometry of spin-glass states. PMID- 9941623 TI - Orientational dynamics of molecular liquid oxygen. PMID- 9941625 TI - Magnetic properties of Pb1-xEuxTe grown by molecular-beam epitaxy. PMID- 9941627 TI - Coherent polaron superlattices and long-range Coulomb forces in quasi-one dimensional conductors. PMID- 9941626 TI - Light scattering from magnons in MnF2. PMID- 9941628 TI - Calculations of the local orbital moment in Y2Co17 using the recursion method. PMID- 9941629 TI - Band-structure calculations for Ni, Ni4H, Ni4H2, Ni4H3, and NiH. PMID- 9941630 TI - Symmetry breaking of a spin glass on a Bethe lattice of infinite coordination. PMID- 9941631 TI - Negative-muon spin precession in ferromagnetic iron and the hyperfine anomaly. PMID- 9941632 TI - Anomalous scaling and generalized Lyapunov exponents of the one-dimensional Anderson model. PMID- 9941633 TI - Multicritical behavior of a square-lattice-gas model with anisotropic repulsive interactions: A transfer-matrix scaling study. PMID- 9941634 TI - Electric-field-dependent average resistance and the resistance fluctuation in one dimensional disordered systems. PMID- 9941635 TI - Correlation functions at two-dimensional criticality and projective transformations. PMID- 9941637 TI - Scaling and deep inelastic neutron scattering from quantum liquids and solids. PMID- 9941636 TI - Characterization of the valence transition in YbxIn PMID- 9941638 TI - Superconductivity and random disorder in the zero-bandwidth limit. PMID- 9941639 TI - Relationship between Hamiltonian and one-spin transfer-matrix descriptions of Ising systems. PMID- 9941640 TI - Correlation functions of order-parameter fluctuations in a Fermi system. PMID- 9941641 TI - Wall orientation near the commensurate-incommensurate transition. PMID- 9941642 TI - Trimodal random-field Ising model on a Bethe lattice and the tricritical point. PMID- 9941643 TI - Phase diagram of the random-field Ising model with a trimodal distribution. PMID- 9941644 TI - Electronic structure of magnetic impurities in copper. PMID- 9941645 TI - Layering and mixing in coadsorbed xenon-ethylene films on graphite. PMID- 9941647 TI - Spiral-lattice-site animals: An exact enumeration study. PMID- 9941646 TI - Determination of the antiferromagnetic exchange constant between nearest-neighbor Gd3+ ions in Pb0.95Gd0.05Te. PMID- 9941648 TI - Time decay of the saturated remanent magnetization in a metallic spin glass. PMID- 9941650 TI - Temperature dependence of the positronium work function. PMID- 9941651 TI - Helium bubbles in metals: Molecular-dynamics simulations and positron states. PMID- 9941649 TI - Muon level-crossing resonance in antiferromagnetic MnF2. PMID- 9941652 TI - High-temperature series expansions to fourth order with a multiple-exchange Hamiltonian for both bcc and hcp phases of solid 3He. PMID- 9941653 TI - Resistance anomalies in the Kondo-lattice system CeCu2-xNixSi2. PMID- 9941654 TI - Random-field effects on Ising Jahn-Teller phase transitions. PMID- 9941656 TI - Automorphic properties of local height probabilities for integrable solid-on solid models. PMID- 9941655 TI - Analysis of critical-exponent data using Efron's bootstrap technique. PMID- 9941658 TI - Synchrotron-radiation-induced photoelectron study of some dilute Agsub1-xMnx alloys. PMID- 9941657 TI - From block-spin expectation values to renormalized couplings. PMID- 9941659 TI - Structural properties of the Ru(0001) surface. PMID- 9941660 TI - Theory of subsurface occupation, ordered structures, and order-disorder transitions for hydrogen on Pd(111). PMID- 9941661 TI - Evanescent absorption in kinematic surface Bragg diffraction. PMID- 9941663 TI - Experimental test of the Mie theory for microlithographically produced silver spheres. PMID- 9941662 TI - Statistical distribution of the resistance in a one-dimensional disordered electrified chain. PMID- 9941664 TI - Extra contribution of transition-metal solutes to the solid-solution hardening of nickel. PMID- 9941665 TI - Bond-orientational anisotropy in metallic glasses observed by x-ray diffraction. PMID- 9941666 TI - Electronic theory of the alloy phase stability of Cu-Ag, Cu-Au, and Ag-Au systems. PMID- 9941667 TI - Sputtering of chemisorbed nitrogen from single-crystal planes of tungsten and molybdenum. PMID- 9941668 TI - Quantum Hall effect with realistic boundary conditions. PMID- 9941669 TI - Noble-gas ion sputtering yield of gold and copper: Dependence on the energy and angle of incidence of the projectiles. PMID- 9941670 TI - Resonant Raman study of intrinsic defect modes in electron- and neutron irradiated GaAs. PMID- 9941671 TI - Generalization of the Landauer conductance formula. PMID- 9941672 TI - Effect of disorder on exciton binding in semiconductor alloys. PMID- 9941673 TI - Phonons in the alloy superlattice GaAs-AlxGa1-xAs. PMID- 9941674 TI - Folded acoustic phonons in Si/GexSi1-x strained-layer superlattices. PMID- 9941675 TI - Theory of magnetoconductivity in a two-dimensional electron-gas system: Self consistent screening model. PMID- 9941676 TI - Electron spectroscopy study of FeSi and CoSi. PMID- 9941677 TI - All-electron self-consistent variational method for Wannier-type functions: Applications to the silicon crystal. PMID- 9941678 TI - X-ray-absorption near-edge structure of titanium and vanadium in (Ti,V)O2 rutile solid solutions. PMID- 9941679 TI - Monte Carlo study of dispersive charge-carrier transport in spatially random systems with and without energetic disorder. PMID- 9941680 TI - Filamentation instability of an Alfven wave in a compensated semiconductor. PMID- 9941681 TI - Electronic properties and optical-absorption spectra of GaAs-AlxGa1-xAs quantum wells in externally applied electric fields. PMID- 9941682 TI - Time-resolved photoluminescence of dense electron-hole plasmas in In-Ga-As-P films. PMID- 9941683 TI - Atomic model for the EL2 defect in GaAs. PMID- 9941684 TI - Total-energy and band-structure calculations for the semimagnetic Cd1-xMnxTe semiconductor alloy and its binary constituents. PMID- 9941686 TI - Epitaxy, overlayer growth, and surface segregation for Co/GaAs(110) and Co/GaAs(100)-c(82). PMID- 9941685 TI - Structural and vibrational properties of a realistic model of amorphous silicon. PMID- 9941687 TI - Passivation of dangling bonds in amorphous Si and Ge by gas adsorption. PMID- 9941689 TI - Vibrational fluctuations of the hydrogen bonds around a nucleation defect of melting in poly(dG)-poly(dC). PMID- 9941688 TI - Impact excitation and bottleneck effects in the time-resolved far-infrared photoresponse of high-purity InP. PMID- 9941690 TI - Resonant Raman scattering and dynamics of the FA(Li+) modes in KCl. PMID- 9941691 TI - Site-selective laser spectroscopy of defect aggregation kinetics in KCl:Sm2+ PMID- 9941692 TI - Amorphous water ice and its ability to trap gases. PMID- 9941693 TI - Microstructure-derived macroscopic residual resistance of brominated graphite fibers. PMID- 9941694 TI - Composition range of binary amorphous alloys. PMID- 9941695 TI - Calculated x-ray photoemission spectrum of UBe13. PMID- 9941697 TI - Surface modes of a pair of unequal spheres. PMID- 9941696 TI - Low-temperature thermal conductivity of glassy and icosahedral Pd-U-Si alloys. PMID- 9941699 TI - Simple description of nonparabolic two-dimensional subbands. PMID- 9941698 TI - Raman coupling-parameter variation in amorphous germanium. PMID- 9941700 TI - Confined electron states in GaAs-Ga1-xAlxAs quantum wires. PMID- 9941702 TI - Comment on "T3 specific-heat anomaly in network solids" PMID- 9941701 TI - Interpretation of the "discrepancy" in the M-bar-point Rayleigh mode in the surface vibrations of LiF(001). PMID- 9941704 TI - Erratum: Theoretical calculation of the pure electronic spectrum of MnF6 4- in vacuo and in RbMnF3 PMID- 9941703 TI - Reply to "Comment on 'T3 specific-heat anomaly in network solids' " PMID- 9941705 TI - Erratum: Influence of the electron-electron interaction on the Aharonov-Bohm effect PMID- 9941707 TI - Incipient localization and the thermopower analog of the Mooij correlation. PMID- 9941706 TI - New surface mode on the (001) surfaces of RbBr and RbI. PMID- 9941708 TI - Point-contact spectroscopy in Al/In heterojunctions. PMID- 9941709 TI - Canonical description of electron states in random alloys. PMID- 9941710 TI - Medium-energy backscattered electron diffraction as a probe of elastic strain in epitaxial overlayers. PMID- 9941711 TI - Transport and superconducting properties of the Mg32(Al,Zn)49-type quasicrystalline and crystalline phases. PMID- 9941712 TI - Photoexcitation spectroscopy of polythiophene. PMID- 9941713 TI - Pressure dependence of the conduction-electron-spin-resonance linewidth of the alpha and beta phases of di-bis(ethylene- diothiolo)tetrathiafulvalene triiodide. PMID- 9941715 TI - Dynamics of excitons localized by stacking disorder in GaSe. PMID- 9941714 TI - Luminescence of multiple modulation-doped GaAs-AlxGa1-xAs heterojunctions in high magnetic fields. PMID- 9941716 TI - LoSurdo-Stark effect for a hydrogenic impurity in a thin layer: Two-dimensional model. PMID- 9941718 TI - Cyclotron-resonance determination of band offset in a PbTe quantum well. PMID- 9941717 TI - High-order resonant Raman scattering by combinations and overtones of interface phonons in GaAs-AlAs short-period superlattices. PMID- 9941719 TI - Fourier-transform infrared-absorption studies of intracenter transitions in the EL2 level in semi-insulating bulk GaAs grown with the liquid-encapsulated Czochralski technique. PMID- 9941720 TI - Coupled-mode stop bands of acoustic phonons in semiconductor superlattices. PMID- 9941721 TI - Electronic properties of the quaternary semiconductor alloy GaSb1-x-yAsxPy: Coherent-potential approximation. PMID- 9941722 TI - Persistent photoconductivity and field-enhanced conductivity in amorphous-silicon doping-modulated superlattices. PMID- 9941723 TI - Photoreflectance modulation mechanisms in GaAs-AlxGa1-xAs multiple quantum wells. PMID- 9941724 TI - Picosecond Raman scattering from photoexcited plasmas in InP with spatial and temporal resolution. PMID- 9941725 TI - Microscopic study of tunneling processes via localized states in amorphous Si/SiOx tunnel barriers. PMID- 9941726 TI - Magnetic-field-enhanced Raman scattering by confined and interface phonons in semiconductor superlattices. PMID- 9941727 TI - Valence- and conduction-band electronic structure of wurtzite CdSe. PMID- 9941728 TI - Pressure-induced bond-angle variation in amorphous SiO2. PMID- 9941729 TI - Optical second-harmonic generation from thallium on silver. PMID- 9941730 TI - Optical and electrical properties of niobium carbide. PMID- 9941731 TI - Dressed-atom approach to embedding and physisorption in metals. PMID- 9941732 TI - Growth of metastable fcc Co on Ni(001). PMID- 9941733 TI - Localization and tunneling effects in percolating systems. PMID- 9941734 TI - Ab initio calculation of extended x-ray-absorption fine structure in Br2. PMID- 9941736 TI - Universal scaling relations in compressibility of solids. PMID- 9941735 TI - Polarized light scattering investigation of UBe13. PMID- 9941738 TI - Perturbation theory for light diffraction with surface-polariton resonances on a bigrating. PMID- 9941737 TI - Force and total-energy calculations for a spatially compact adsorbate on an extended, metallic crystal surface. PMID- 9941739 TI - Dispersion anomalies of surface plasmons on corrugated metal-insulator interfaces. PMID- 9941740 TI - Near-edge x-ray-absorption fine structure in uranium compounds. PMID- 9941741 TI - Fe and Mn sites in noncrystallographic alloy phases of Al-Mn-Fe and Al-Mn-Fe-Si. PMID- 9941743 TI - Thermoelectric power and elastoresistance of TaSe3. PMID- 9941742 TI - Surface-plasmon excitation by electrons in microlithographically produced channels. PMID- 9941744 TI - Infrared-laser excitation of the internal vibrational mode of a diatomic molecule adsorbed on a metal surface. PMID- 9941745 TI - Nuclear-magnetic-resonance powder patterns in Al6Mn, Al4Mn, and Al12Mn polycrystals. PMID- 9941746 TI - Ab initio electronic structure calculations for point defects in CoAl and CoGa. PMID- 9941747 TI - Structural relaxation of amorphous Zr70Cu30 and its effect on the electronic properties. PMID- 9941749 TI - Beam-induced annealing of defects in silicon after light-ion implantation at 30 K. PMID- 9941748 TI - Dynamic local-field factor of an electron liquid in the quantum versions of the Singwi-Tosi-Land-Sjolander and Vashishta-Singwi theories. PMID- 9941750 TI - Optical absorption tails and structural disorder in SnxGe1-xSe2.5 and other chalcogenide alloy glasses and liquids. PMID- 9941751 TI - Potential fluctuations and density of gap states in amorphous semiconductors. PMID- 9941752 TI - Thomas-Fermi-Dirac dielectric function for GaAs and GaP. PMID- 9941753 TI - The 3942-cm-1 optical band in irradiated silicon. PMID- 9941754 TI - Properties of (GaAs)1-xGe2x and (GaSb)1-xGe2x: Consequences of a stochastic growth process. PMID- 9941756 TI - Development of a many-body Tersoff-type potential for silicon. PMID- 9941755 TI - Role of conformational disorder in the electronic structure of conjugated polymers: Substituted polydiacetylenes. PMID- 9941757 TI - Temperature dependence of electron mobility in GaAs-Ga1-xAlxAs modulation-doped quantum wells. PMID- 9941758 TI - Influence of the supercell structure on the folded acoustical Raman line intensities in superlattices. PMID- 9941759 TI - Photocarrier generation and transport in sigma -bonded polysilanes. PMID- 9941760 TI - Semiempirical band structure and partial density of states of CuCl. PMID- 9941762 TI - Temperature dependence of the high-frequency resistivity of a type-I superlattice due to impurity and phonon scatterings. PMID- 9941761 TI - Carrier kinetics in a surface-excited semiconductor slab: Influence of boundary conditions. PMID- 9941763 TI - Manganese-derived partial density of states in Cd1-xMnxTe. PMID- 9941765 TI - Capture of free excitons by phosphorus and boron in bilayered silicon crystals. PMID- 9941764 TI - Magnetoconductance due to parallel magnetic fields in silicon inversion layers. PMID- 9941767 TI - Anomalous magnetic properties of triplet excited states in crystalline and amorphous arsenic triselenide. PMID- 9941766 TI - Coupling between two dangling bonds in polycrystalline silicon. PMID- 9941768 TI - Resonance Raman scattering by optical phonons in GaAs near the E0 band gap. PMID- 9941770 TI - Behavior of the electron-hole gas in quantum wells in GaAs-AlxGa1-xAs heterostructures under in-plane magnetic fields. PMID- 9941769 TI - Resonant Raman study of low-temperature exciton localization in GaAs quantum wells. PMID- 9941771 TI - Theoretical approach for n-i-p-i silicon. PMID- 9941772 TI - Dielectric and neutron diffraction studies of radiation damage on modulated deuterated thiourea PMID- 9941773 TI - Optical spectroscopy of Pb2+ in doubly doped KCl:Sr(Pb): Detection of Sr precipitates. PMID- 9941774 TI - Origin of the characteristic electron density distribution in silver halides. PMID- 9941775 TI - Bipolarons in boron icosahedra. PMID- 9941776 TI - Dynamics of zirconium oxide thin-film growth and ion-beam etching. PMID- 9941778 TI - Electronic and atomic structure of amorphous carbon. PMID- 9941777 TI - Polaron in N dimensions. PMID- 9941779 TI - Electronic structure of stage-2 SbCl5-intercalated graphite. PMID- 9941780 TI - Nuclear magnetic resonance in higher-stage graphite intercalation compounds. PMID- 9941781 TI - Time-resolved photoluminescence in amorphous silicon dioxide. PMID- 9941782 TI - Thermal effects of the refractive index caused by the electron-phonon interaction. PMID- 9941783 TI - Tight-binding studies of Ga1-xAlxAs. PMID- 9941784 TI - Influence of surface corrugations on electron-stimulated desorption: Angular distributions of ions and neutral atoms from Ni(110)-CO. PMID- 9941785 TI - Systematics in bonding of simple adsorbates on a transition-metal surface. PMID- 9941786 TI - Light-scattering cross sections of Ca2+ and the calcium-cation-vacancy complex in KBr. PMID- 9941788 TI - X-ray diffraction and Mossbauer-effect study of the decagonal Al7(Mn1-xFex)2 alloy. PMID- 9941787 TI - Correlation effects on the third-frequency-moment sum rule of electron liquids. PMID- 9941789 TI - Exciton binding energy in a quantum-well wire. PMID- 9941790 TI - Low-electronegativity overlayers and enhanced semiconductor oxidation: Sm on Si(111) and GaAs(110) surfaces. PMID- 9941791 TI - Oscillations in the photoconductivity of Si:Au: Possible new evidence for chaos. PMID- 9941792 TI - Discrete symmetries and selection rules for the polyacetylene model. PMID- 9941793 TI - Bonding characteristics of the sqrt 3 PMID- 9941794 TI - Analysis of resonant Raman scattering spectra of fully oriented undoped and iodine-doped trans-polyacetylene: Experiments and theory. PMID- 9941796 TI - Scanning-tunneling-microscopy study of the Au(334) surface in air. PMID- 9941795 TI - Electron and quasiparticle density of states in the fractionally quantized Hall effect. PMID- 9941797 TI - Pressure-induced elimination of the hole gas in semimetallic GaSb-InAs-GaSb heterostructures. PMID- 9941798 TI - Detrapping of positrons and thermal stability of phosphorus-vacancy pairs in silicon. PMID- 9941799 TI - Surface vibrational spectroscopy by infrared-visible sum frequency generation. PMID- 9941800 TI - EPR and optical-absorption studies of Cmsup3+ in YPO4 and LuPO4 single crystals. PMID- 9941801 TI - Electronic excitations in the transition metals V, Zr, Nb, Mo, and Ta. PMID- 9941802 TI - Coherent quasielastic neutron scattering from NbDx. PMID- 9941803 TI - Unusual Mossbauer phenomenon in LixFePS3. PMID- 9941804 TI - Solid-effect rate equations for a spin-1 nucleus. PMID- 9941805 TI - Neutron scattering studies of the paramagnetic response in the mixed-valence alloy Ce1-xThx at high energy. PMID- 9941806 TI - Low-energy electron and positron diffraction measurements and analysis on Cu(100). PMID- 9941807 TI - Coherent anti-Stokes Raman scattering in PrF3. PMID- 9941808 TI - Tetragonal Ni+ ions in x-ray-irradiated KMgF3:Ni. PMID- 9941809 TI - Neutron scattering, magnetization, and Mossbauer measurements on EuPd2Si2 with enriched 153Eu isotopes. PMID- 9941811 TI - Subharmonic locking in Josephson weak links. PMID- 9941810 TI - Positron annihilation from F centers of alkali halide crystals. PMID- 9941813 TI - Intrinsic fluctuations of the vortex-line density in superfluid turbulence. PMID- 9941812 TI - High-velocity growth of solid 4He. PMID- 9941814 TI - Magnetic polarons in low-density solid 3He. PMID- 9941815 TI - Superconducting transitions in Hg3- delta SbF PMID- 9941816 TI - Fractal multilayered superconductors. PMID- 9941817 TI - 3He-4He mixture as a weak link for Josephson effects in superfluid 3He. PMID- 9941818 TI - Localization, superconducting fluctuations, and superconductivity in thin films and narrow wires of aluminum. PMID- 9941819 TI - Space-time pattern formation and conversion in the dc-driven, damped sine-Gordon equation. PMID- 9941820 TI - Superconducting properties of In-Ge mixture films. PMID- 9941821 TI - Toxen relation for the energy gap. PMID- 9941822 TI - Dependence of the upper critical field on the spectral density for arbitrary impurity concentrations. PMID- 9941823 TI - Anomalous behavior of the superconducting critical temperature of Mo-V superlattices. PMID- 9941824 TI - Superconductive quantum size effect in indium films. PMID- 9941825 TI - Effects of paramagnons in a proximity sandwich. PMID- 9941826 TI - Melnikov's method for nonperiodic perturbations and the bifurcations in a Josephson junction. PMID- 9941827 TI - Hyperfine fields of 3d and 4d impurities in nickel. PMID- 9941828 TI - Anisotropic electrical conductivity in heterogeneous solids with cylindrical conducting inclusions. PMID- 9941829 TI - Magnetic susceptibility and heat capacity of Ce2Sn5. PMID- 9941830 TI - Elastic effects in intercalation compounds: Comparison of lithium in graphite and TiS2. PMID- 9941831 TI - Phenomenology and neglect of irrelevant variables for ferromagnetic systems. PMID- 9941832 TI - High-field magnetization of (Cd,Mn)Te. PMID- 9941833 TI - Structure of high-stage potassium-intercalated graphite. PMID- 9941835 TI - Quantum statistics of easy-plane ferromagnetic chains and specific heat of CsNiF3 and (C6H PMID- 9941834 TI - Magnetic excitations in the longitudinally polarized antiferromagnetic phase of praseodymium. PMID- 9941836 TI - Monte Carlo study of the antiferromagnetic two-dimensional Blume-Capel model. PMID- 9941837 TI - Ising spin dynamics on fractal lattices. PMID- 9941838 TI - Two-dimensional Hubbard model with nearest- and next-nearest-neighbor hopping. PMID- 9941839 TI - Pressure dependences of the elastic moduli and the diffuse ferroelectric phase transition in PbMg1/3Nb2/3O3. PMID- 9941840 TI - Critical behavior in nonequilibrium phase transitions. PMID- 9941841 TI - Density-functional approach to phase transitions of submonolayer films. I. The role of the intrinsic and extrinsic ordering forces. PMID- 9941842 TI - Density-functional approach to phase transitions of submonolayer films. II. The role of the relaxation mechanisms. PMID- 9941843 TI - Large-orbital-degeneracy expansion for the lattice Anderson model. PMID- 9941844 TI - Effect of electron-phonon interaction on spin susceptibility in A15 compounds. PMID- 9941845 TI - Monte Carlo studies of Ising ferromagnets and the Villain model in transverse fields. PMID- 9941846 TI - Thomas-Fermi theory of screening of a positive point charge in an insulator. PMID- 9941847 TI - Close packings of uniform disks with perfect orientational order. PMID- 9941848 TI - Sine-Gordon system as a Toda lattice: Thermodynamics in the classical limit. PMID- 9941850 TI - Random exchange effects in antiferromagnetic quantum spin chains: A Monte Carlo study. PMID- 9941849 TI - Ferromagnets with weak random anisotropy. PMID- 9941852 TI - Frustrated XY model with screening. PMID- 9941851 TI - Transport anisotropy and percolation in the two-dimensional random-hopping model. PMID- 9941853 TI - Time-reversal invariance and universality of two-dimensional growth models. PMID- 9941855 TI - Monte Carlo study of glassy order in two-dimensional Lennard-Jones systems. PMID- 9941854 TI - Hamiltonian dynamics of the double sine-Gordon kink. PMID- 9941856 TI - Resistance fluctuations in randomly diluted networks. PMID- 9941858 TI - Cluster-variation calculation for random-field systems: Application to hydrogen in niobium alloys. PMID- 9941857 TI - Large-n -limit model for quantum structural phase transitions with correlated random fields. PMID- 9941859 TI - Physical significance of local-density-functional-theory eigenvalues. PMID- 9941860 TI - Critical surface free energies and universal finite-size scaling amplitudes of three-dimensional XY models by direct Monte Carlo sampling. PMID- 9941861 TI - Nuclear-quadrupole-resonance line shapes for spin 1 and the incommensurate structure of the 20r polytype of K3Co(CN)6 at low temperature. PMID- 9941862 TI - Thermofield quantum Monte Carlo method and its applications to quantum spin systems. PMID- 9941863 TI - Unusual magnetic response of intermediate-valent YbPd and Yb3Pd4 as studied by inelastic neutron scattering. PMID- 9941865 TI - Surface spin reorientation in thin Gd films on Fe in an applied magnetic field. PMID- 9941864 TI - Nonasymptotic critical behavior from field theory at d=3. II. The ordered-phase case. PMID- 9941866 TI - Critical behavior of a semi-infinite Ising model with an edge. PMID- 9941867 TI - Conformation of a polymer chain at the theta' point: Connection to the external perimeter of a percolation cluster. PMID- 9941868 TI - Dimerization model for the metal-semiconductor transition in BaPb1-xBix PMID- 9941870 TI - Quantum-mechanical derivation of the equations of motion for Davydov solitons. PMID- 9941869 TI - Pinning forces and defects as measured by critical currents in amorphous superconducting materials. PMID- 9941872 TI - Nonequilibrium phase transition to a time-dependent probability density for a model of charge-density waves. PMID- 9941871 TI - Pressure-induced phase transitions in KLiSO4. PMID- 9941873 TI - Use of scaling plots in phase-transition studies. PMID- 9941874 TI - Solitary waves in one-dimensional damped systems. PMID- 9941875 TI - Structure dependence of final-state effects in deep inelastic neutron scattering: Quasiclassical theory. PMID- 9941876 TI - Hard-core repulsive interactions in even-parity electron pairings for heavy fermion systems. PMID- 9941877 TI - Penetration depth of a superconducting superlattice. PMID- 9941878 TI - Magnetic properties of the two-dimensional n=0 vector model. PMID- 9941879 TI - Percolation on a random lattice. PMID- 9941880 TI - Composition modulation of K-Rb mixtures in graphite. PMID- 9941881 TI - Random-exchange Heisenberg antiferromagnetic chains in Langmuir-Blodgett films of N-docosylpyridinium-bistetracyanoquinodimethane. PMID- 9941882 TI - Frustrated nearest-neighbor d=2 Ising model: Exact results. PMID- 9941883 TI - Multilayer phase diagram of CF4 adsorbed on graphite. PMID- 9941884 TI - Random-field model of exchange anisotropy at rough ferromagnetic antiferromagnetic interfaces. PMID- 9941885 TI - Monte Carlo simulation of the growth of wetting layers. PMID- 9941887 TI - New wave-vector selection rule for photoemission from a semi-infinite crystalline solid. PMID- 9941886 TI - YbSi: A nearly localized heavy-fermion antiferromagnet. PMID- 9941888 TI - Ground-state and thermodynamic properties of the Hubbard model applied to small clusters. PMID- 9941890 TI - Multipolar response of small metallic spheres: Nonlocal theory. PMID- 9941889 TI - Formation and structure of icosahedral and glassy phases in melt-spun Al-Si-Mn. PMID- 9941891 TI - Resonances in the photoemission cross section of a surface state: Results for Ag(111). PMID- 9941893 TI - Observation of bulk tantalum oxide formation below 35 K. PMID- 9941892 TI - Electronic structure and chemical properties of Pt overlayers on Nb(110). PMID- 9941894 TI - Acoustical polaron in three dimensions: The impedance function. PMID- 9941895 TI - Substrate effects on surface-plasmon spectra in metal-island films. PMID- 9941896 TI - Optical properties of scandium thin films. PMID- 9941897 TI - Photoemission, inverse photoemission, and fluctuations in an exactly soluble many body cluster model of bcc iron. PMID- 9941899 TI - Modified form of the cluster-variation method. PMID- 9941898 TI - Geometry of (22)S/Cu(001) determined with use of angle-resolved-photoemission extended fine structure. PMID- 9941901 TI - Effective electron-density variation and atomic configuration of Al in AlxGa1 xAs. PMID- 9941900 TI - Dirac scattered-wave calculations on an icosahedral Au13 cluster. PMID- 9941902 TI - Uniaxial stress study of photoluminescence defects created by noble-gas implantation into silicon. PMID- 9941904 TI - Plasmon and electron-hole-pair damping of excited vibrational and electronic states in quasi-two-dimensional electron systems. PMID- 9941903 TI - EPR studies of heat-treatment centers in p-type silicon. PMID- 9941905 TI - Long-range order in (GaAs)1-xGe2x and (GaSb)1-xGe2x: Predictions for <111> growth. PMID- 9941906 TI - Optically induced long-lifetime photoconductivity in semi-insulating bulk GaAs. PMID- 9941907 TI - Spin relaxation of holes in the split-hole band of InP and GaSb. PMID- 9941908 TI - Non-muffin-tin formalism for random-semiconductor-alloy calculations. PMID- 9941909 TI - Lattice-dynamical and photoelastic properties of GaSe under high pressures studied by Raman scattering and electronic susceptibility. PMID- 9941911 TI - Magnetoplasma modes in thin films in the Faraday configuration. PMID- 9941910 TI - Effect of an applied magnetic field on interface excitations in finite layered structures. PMID- 9941912 TI - Theory of polar scattering in semiconductor quantum structures. PMID- 9941914 TI - Symmetry of Si(111)77 at an a-Si interface. PMID- 9941913 TI - Reduction of charge-center scattering rate in Hg1-xFexSe. PMID- 9941916 TI - Electronically stimulated deep-center reactions in electron-irradiated InP: Comparison between experiment and recombination-enhancement theories. PMID- 9941915 TI - Theory of bipolaron lattices in quasi-one-dimensional conducting polymers. PMID- 9941917 TI - Magnetophonon oscillation of the transverse magneto-Seebeck-coefficient in semiconductors. PMID- 9941918 TI - Electronic structure, atomic structure, and the passivated nature of the arsenic terminated Si(111) surface. PMID- 9941919 TI - Electronic structure of M3ISb-type filled tetrahedral semiconductors. PMID- 9941920 TI - Raman scattering study of coupled hole-plasmon-LO-phonon modes in p-type GaAs and p-type AlxGa1-xAs. PMID- 9941921 TI - Green's-function approach to transient hot-electron transport in semiconductors under a uniform electric field. PMID- 9941923 TI - Three-body contribution to the adsorption potential of atoms on graphite. PMID- 9941922 TI - Self-consistent calculations of the two-dimensional electron density in modulation-doped superlattices. PMID- 9941924 TI - New secondary relaxation in polymeric glasses: A possible common feature of the glassy state. PMID- 9941925 TI - Density-functional study of the NiO6 10- cluster. PMID- 9941926 TI - Laser-induced phonon-polariton coupling with x rays in the symmetric Bragg geometry. PMID- 9941927 TI - Enhancements of laser-induced phonon-polariton coupling with x rays in the symmetric Laue geometry. PMID- 9941928 TI - Photothermal analysis of synergistic radiation effects in ThF4 optical thin films. PMID- 9941929 TI - Tunneling dynamics of doped organic low-temperature glasses as probed by a photophysical hole-burning system. PMID- 9941931 TI - Raman spectroscopy of submicron KNO3 films. PMID- 9941930 TI - Photoconductivity of the nickel dihalides and the nature of the energy gap. PMID- 9941932 TI - Optical response and band-structure calculations of alkaline-earth tellurides under pressure. PMID- 9941933 TI - Optical spectra of two-dimensional butadiene iron tricarbonyl in the adsorbed state. PMID- 9941934 TI - Thermal conductivity of amorphous solids above the plateau. PMID- 9941935 TI - Image states of a corrugated metal surface. PMID- 9941936 TI - One-dimensional quantum electron system under a finite voltage. PMID- 9941937 TI - Stability of Cu3: A variational and perturbational configuration-interaction study. PMID- 9941938 TI - Icosahedral particles of an Al-Mn alloy produced by gas evaporation. PMID- 9941939 TI - Electronic band structure of rhombohedral arsenic studied by angle-resolved photoemission with synchrotron radiation. PMID- 9941940 TI - Observation of P1/2 resonant states and Fano resonances of the deep gold acceptor in silicon. PMID- 9941941 TI - Transport relaxation time of a two-dimensional electron gas due to scattering by surface acoustic waves. PMID- 9941942 TI - Quantum size effects in spherical semiconductor microcrystals. PMID- 9941943 TI - Vibrational modes around the soliton in strongly coupled one-dimensional electron lattice systems. PMID- 9941944 TI - Search for kinetic properties of solitons in polyacetylenes. PMID- 9941945 TI - Relationship between laser-induced gratings and vibrational properties of Eu doped glasses. PMID- 9941946 TI - Screening of the intermolecular van der Waals interaction at a metal surface. PMID- 9941947 TI - Sum rules for the nonlinear susceptibilities in the case of sum frequency generation. PMID- 9941948 TI - Erratum: Polaronic states in a slab of a polar crystal PMID- 9941949 TI - Orientation and bond length of molecular oxygen on Ag(110) and Pt(111): A near edge x-ray-absorption fine-structure study. PMID- 9941950 TI - Voltage fluctuations in small conductors. PMID- 9941951 TI - Elastic constants of Mo/Ta superlattices measured by Brillouin scattering. PMID- 9941952 TI - Minority-spin states for V and Mn on Ag(111) by inverse photoemission. PMID- 9941953 TI - Picosecond time-resolved Raman studies of the expansion of the electron-hole plasma in Si. PMID- 9941954 TI - Unoccupied surface states revealing the Si(111) sqrt 3 sqrt 3 -Al, -Ga, and -In adatom geometries. PMID- 9941955 TI - Observtion of an oxygen-related mobility-gap defect in ion-implanted hydrogenated amorphous silicon films. PMID- 9941956 TI - Intersubband energies in GaAs-Ga1-xAlxAs heterojunctions. PMID- 9941957 TI - Intersubband optical absorption in a quantum well with an applied electric field. PMID- 9941959 TI - Comparison of high-temperature and laser-quenched Si(111) using low-energy electron diffraction. PMID- 9941958 TI - Exciton binding energy in type-II GaAs-(Al,Ga)As quantum-well heterostructures. PMID- 9941961 TI - Noise-power temperature for steady-state hot-electron systems in semiconductors. PMID- 9941960 TI - Monte Carlo simulation of planar channeling in superlattices. PMID- 9941963 TI - Quasiparticle energies in GaAs and AlAs. PMID- 9941962 TI - Defects in single-crystal silicon induced by hydrogenation. PMID- 9941964 TI - Periodic negative conductance by sequential resonant tunneling through an expanding high-field superlattice domain. PMID- 9941965 TI - Local-density-functional results for the dimerization of trans-polyacetylene: Relationship to the band-gap problem. PMID- 9941966 TI - X-ray diffraction study of anharmonicity in Vsub3Si. PMID- 9941967 TI - Growth dynamics at a metal-metal interface. PMID- 9941968 TI - Electron scattering by electron holograms: The physical interpretation of the Coulomb anomaly in disordered electron systems. PMID- 9941969 TI - High-resolution photoemission study of Co/Si(111) interface formation. PMID- 9941970 TI - Quantum reflection and dissipation. PMID- 9941971 TI - Asymmetric line shapes and the electron-hole pair mechanism for adsorbed molecules on surfaces. PMID- 9941972 TI - Electron emission from a metal surface bombarded by slow highly charged ions. PMID- 9941974 TI - Optical properties of UBe13, CeBe13, and ThBe13. PMID- 9941973 TI - Adsorption of molecular nitrogen on clean and modified Ru(001) surfaces: The role of sigma bonding. PMID- 9941975 TI - Neutron diffraction and the structure of amorphous Ni0.95Tb0.05. PMID- 9941976 TI - Reconstructed W(001) surface: distortion and phonons at T=0. PMID- 9941977 TI - Photofield emission from transition-metal surface states. PMID- 9941979 TI - Proof of the nonexistence of (formal) phase transitions in polaron systems. II. PMID- 9941978 TI - Proof of the nonexistence of (formal) phase transitions in polaron systems. I. PMID- 9941980 TI - Localized 3p excitations in 3d transition-metal-series spectroscopy. PMID- 9941981 TI - Linear response of an inhomogeneous electron gas. PMID- 9941982 TI - Relativistic spin-polarized densities in a scattering-theory formulation: Applications to the electronic structure of plutonium. PMID- 9941984 TI - Surface-sandwich segregation in Pt-Ni and Ag-Ni alloys: Two different physical origins for the same phenomenon. PMID- 9941983 TI - Excitonic trions in a low magnetic field. PMID- 9941985 TI - Resonance Raman scattering from defects in CdSe. PMID- 9941986 TI - Radiation effects and anelastic loss in germanium-doped quartz. PMID- 9941987 TI - Fundamental absorption edge of SrTiO3 at high temperatures. PMID- 9941988 TI - Hot electrons in one dimension. II. Backscattering. PMID- 9941989 TI - Absorption edge of the amorphous (GeS2)x(As2S3)1-x system under hydrostatic pressure. PMID- 9941990 TI - Nonlinear electron-phonon dynamics: The appearance of solitary excitations and localized modes. PMID- 9941992 TI - Luminescence quenching of an ultrathin tetraphenylporphyrin film on a conductive SnO2 substrate. PMID- 9941991 TI - High-resolution 13C NMR investigation of the metal-semiconductor transition in an organic conductor. PMID- 9941993 TI - Interface polaron in a strong magnetic field. PMID- 9941994 TI - Ballistic electron transport in thin silicon dioxide films. PMID- 9941995 TI - Theoretical study of superionic SrCl2 below the critical temperature by a simple model. PMID- 9941996 TI - Local and nonlocal surface nonlinearities for surface optical second-harmonic generation. PMID- 9941997 TI - Fourth-order perturbation calculation of the cyclotron resonance frequency of the two-dimensional polaron. PMID- 9941999 TI - Defect clusters in wustite Fe1-xO. PMID- 9942000 TI - Central mode in hyper-Raman spectra of the quasi-one-dimensional hydrogen-bonded ferroelectric CsH2PO4. PMID- 9941998 TI - Polaron ground-state energy in two dimensions. PMID- 9942001 TI - Lattice dynamics of molecular calcite crystals. PMID- 9942002 TI - Optical properties of transition-metal ions in zirconium-based metal fluoride glasses and MgF2 crystals. PMID- 9942003 TI - Pressure dependence of the c-axis resistivity of graphite. PMID- 9942004 TI - Quasicrystallinity of icosahedral Pd58.8U20.6Si20.6. PMID- 9942005 TI - Theory for the low-temperature dependence of the ultrasonic attenuation in heavy fermion metals. PMID- 9942006 TI - Extended x-ray-absorption fine structure of a system of mixed phases. PMID- 9942007 TI - Lattice dynamics of gamma -Fe. PMID- 9942009 TI - Polaron effects on excitons in GaAs-Ga1-xAlxAs quantum wells. PMID- 9942008 TI - Evidence of two Bi sites from EPR of Mn2+ in Bi-doped amorphous germanium chalcogenides. PMID- 9942010 TI - Relativistic corrections to the semiconducting properties of selected materials. PMID- 9942012 TI - Linear, nonlinear optical, and related properties of some mixed Cu-BIII-C2VI chalcopyrites. PMID- 9942011 TI - Magneto-optical studies of GaAs-AlxGa1-xAs multi-quantum-well structures grown by molecular-beam epitaxy. PMID- 9942013 TI - Charge transfer in stage-1 OsF6- and MoF6-intercalated graphite compounds. PMID- 9942015 TI - Lifetime in a two-dimensional image-potential-induced electron band. PMID- 9942014 TI - Orientation relationship of decagonal quasicrystal and tenfold twins in rapidly cooled Al-Fe alloy. PMID- 9942016 TI - Nonlinear magnetoresistance and charge-density-wave depinning at liquid-helium temperatures in NbSe3. PMID- 9942017 TI - Inelastic scattering time in three-dimensional nearly magnetic disordered fermion systems. PMID- 9942018 TI - Interaction of optical phonons with electrons in an InAs quantum well. PMID- 9942019 TI - Moumlssbauer studies of Ta1-xFexS3 (0.0012 <= x <= 0.5) and their charge-density waves. PMID- 9942020 TI - Energy loss of MeV light ions specularly reflected from a SnTe(001) surface. PMID- 9942021 TI - 87Rb NMR study of the paraelectric-antiferroelectric phase transition in Rb0.22(ND4)0.78D2PO2. PMID- 9942022 TI - N-shell core-level widths for the elements 74W to 83Bi. PMID- 9942023 TI - Calculation of the energy spectrum and eigenfunctions for a model system of interacting XH3 groups in the low-temperature limit. PMID- 9942024 TI - Systematics in the ionization states of 57Fe following the electron-capture decay of 57Co in different rare-gas matrices. PMID- 9942026 TI - Theory of disorder-induced increase and degradation of superconducting Tc. PMID- 9942025 TI - Transferred hyperfine interaction in the ESR spectra of Eu2+ in CdTe. PMID- 9942028 TI - Resonant activation of a Brownian particle out of a potential well: Microwave enhanced escape from the zero-voltage state of a Josephson junction. PMID- 9942027 TI - Current-carrying state in a polar-phase superconductor at T=0. PMID- 9942030 TI - Effects of the dipole interaction in superfluid 3He-B. PMID- 9942029 TI - Variable superconducting quantum-interference device: Theory. PMID- 9942031 TI - X-ray study of phases and structures in 3He-4He solid solutions. PMID- 9942033 TI - Proximity effect and the thermodynamic properties of superconducting thin films. PMID- 9942032 TI - Specific heat of thin-film A15 superconductors: An anomalous inhomogeneity discovered. PMID- 9942035 TI - Strongly interacting fermions. PMID- 9942034 TI - Two-dimensional virial and spin-wave coefficients of spin-polarized gases (H PMID- 9942036 TI - Hydrodynamic description of collective modes in heavy-fermion superconductors. PMID- 9942037 TI - Superconductivity in the generalized periodic Anderson model with strong local attraction. PMID- 9942038 TI - Adsorption and capillary condensation of 4He on Nuclepore: Third-sound and capacitance measurements. PMID- 9942039 TI - Perturbation analysis of a parametrically changed sine-Gordon equation. PMID- 9942040 TI - Oxygen and rare-earth doping of the 90-K superconducting perovskite YBa2Cu3O7-x. PMID- 9942041 TI - Vortices with half magnetic flux quanta in "heavy-fermion" superconductors. PMID- 9942042 TI - Impedance of radio-frequency-biased resistive superconducting quantum interference devices. PMID- 9942043 TI - Green's-function theory of the anisotropic Heisenberg model in a transverse field. PMID- 9942044 TI - Monte Carlo study of a triangular Ising lattice-gas model with two-body and three body interactions. PMID- 9942045 TI - Residual entropy and validity of the third law of thermodynamics in discrete spin systems. PMID- 9942046 TI - Perturbation theory of impurity diffusion. PMID- 9942047 TI - Pulse-duration memory effect and deformable charge-density waves. PMID- 9942048 TI - Brillouin spectroscopy of polarization fluctuations in Rb1-x(NH4)xH2PO4 mixed crystals: Concentration dependence. PMID- 9942049 TI - Specific heat of the degenerate Kondo model: Exact results in the presence of crystal fields. PMID- 9942050 TI - Spin-fluctuation effects in CeSix alloys: High-field heat-capacity, magnetic susceptibility, and electrical resistivity studies, and a comment on TiBe2. PMID- 9942051 TI - Frequency dependence of the ac susceptibility in the random anisotropy system Dy(P1-xVx)O4. PMID- 9942053 TI - Breakdown properties of quenched random systems: The random-fuse network. PMID- 9942052 TI - Influence of an external magnetic field on the reentrant spin-glass transition temperature in a Cr75Fe25 alloy. PMID- 9942054 TI - Antiferromagnetic correlations in almost-localized Fermi liquids. PMID- 9942055 TI - Quantum Monte Carlo simulations of many-body phenomena in a single-impurity Anderson model. PMID- 9942056 TI - Experimental study of the critical scattering from a two-dimensional random Ising antiferromagnet. PMID- 9942058 TI - Grain boundaries with impurities in a two-dimensional lattice-gas model. PMID- 9942057 TI - Gap problem for the Hubbard chain at finite temperatures: Solution via the Bethe ansatz method. PMID- 9942059 TI - Equivalence of the dynamical and total-energy approaches in the calculation of elastic constants of magnetic metals. PMID- 9942060 TI - Theory of the Anderson lattice at finite temperatures. PMID- 9942061 TI - Electronic structure of the hydride Pd3FeH. PMID- 9942062 TI - Dielectric and electrothermal measurements on (Cd0.83Pb0.17)2Nb2O7 at liquid nitrogen temperatures. PMID- 9942063 TI - Critical behavior of the isotropic ferromagnetic Heisenberg chain with arbitrary spin S. PMID- 9942064 TI - Measurement of the B1-B2 transition pressure in NaCl at high temperatures. PMID- 9942065 TI - Pinning, metastability, and sliding of charge-density waves in an electric field. PMID- 9942066 TI - Resistivity from magnetic impurity pairs in metallic alloys. PMID- 9942067 TI - Nonuniversal critical dynamics of the alternating-bond Ising chain: Relaxational and diffusive kinetics. PMID- 9942068 TI - Longitudinal spin susceptibility and spin dynamics of field-induced spin-density waves in Bechgaard salts. PMID- 9942069 TI - Spin thermodynamics of periodically time-dependent systems: The quasistationary state and its decay. PMID- 9942070 TI - Magnetization in a quenched random-bond transverse Ising model with competing interactions. PMID- 9942071 TI - Nearest-neighbor frustrated random-bond model in d=2: Some exact results. PMID- 9942073 TI - High-temperature series expansion for spin glasses. II. Analysis of the series. PMID- 9942072 TI - High-temperature series expansion for spin glasses. I. Derivation of the series. PMID- 9942075 TI - Crystallization of dense magnetic polarons in degenerate magnetic semiconductors. PMID- 9942074 TI - Monte Carlo study of dynamic universality in two-dimensional Potts models. PMID- 9942077 TI - Anisotropic magnetic properties of single crystals of SmRh4B4. PMID- 9942076 TI - Multilattice microcanonical simulation of the three-dimensional three-state Potts model. PMID- 9942078 TI - Three-body interactions, scaling variables, and singular diameters in the coexistence curves of fluids. PMID- 9942079 TI - Proton and 45Sc nuclear-magnetic-resonance study of hydrogen diffusive hopping in hcp scandium. PMID- 9942080 TI - Dynamic spin susceptibility of semimagnetic semiconductors. PMID- 9942081 TI - Nonlinear travelling waves in ferroelectrics. PMID- 9942082 TI - Dynamical diffraction of x rays by perfect magnetic crystals. PMID- 9942083 TI - Domain-wall interactions. I. General features and phase diagrams for spatially modulated phases. PMID- 9942084 TI - Interface in an Ising model with a spatially varying coupling constant. PMID- 9942085 TI - Finite-temperature spectral density for the Anderson model. PMID- 9942086 TI - Diffusion and dynamical transition in hierarchical systems. PMID- 9942088 TI - Calculation of momentum distribution of positronium ejected from surfaces. PMID- 9942087 TI - Spin-density waves in heavy-fermion compounds: A theoretical study. PMID- 9942090 TI - New form of pair interaction in superconductivity in pressure-sensitive systems. PMID- 9942089 TI - Analysis of the electron paramagnetic resonance zero-field splitting for Fe3+ in sapphire. PMID- 9942091 TI - Magnetization and susceptibility studies of the superconductive compound Gd1Ba2Cu3Oz. PMID- 9942092 TI - Point-contact characteristics obtained with single-phase Y-Ba-Cu-O superconductors. PMID- 9942094 TI - Normal-state gap transition in Cu-O superconductors. PMID- 9942093 TI - Raman study of lattice modes in the high-critical-temperature superconductor Y-Ba Cu-O. PMID- 9942095 TI - Optical properties of La1.85Sr0.15CuO4: Evidence for strong electron-phonon and electron-electron interactions. PMID- 9942096 TI - Far-infrared reflectivity of La2-xSrx PMID- 9942097 TI - Paramagnetic resonance of Cu2+ ions in the superconductor Y0.2Ba0.8CuOx. PMID- 9942098 TI - High-Tc superconductivity in the La1.8Sr0.2CuO4 and Y1.2Ba0.8CuO4 systems. PMID- 9942100 TI - Theoretical description of spin-density waves in heavy-fermion systems. PMID- 9942099 TI - Implications of infrared instability in a two-dimensional electron gas. PMID- 9942101 TI - Noise rise in parametric amplifiers. PMID- 9942102 TI - Transport calculations in arbitrarily polarized liquid 3He. PMID- 9942103 TI - Mechanism of the anomalous increase of the specific heat of helium II near the lambda point. PMID- 9942105 TI - Explicit renormalization-group analysis of the D=2 random-bond Ising model. PMID- 9942104 TI - Mossbauer study of Ni0.01Fe0.99S. PMID- 9942106 TI - Critical amplitudes for correlated percolation. PMID- 9942107 TI - Ferromagnetic transition in dilute Pd-Co alloys. PMID- 9942109 TI - Phase transitions in asymmetric Potts models: Breakdown of the classical mean field picture. PMID- 9942108 TI - Defects and the first-order phase transitions in AgI. PMID- 9942110 TI - Splitting of the Neel transition in holmium in a magnetic field. PMID- 9942111 TI - Characterization of the mixed-valence to heavy-fermion transition in CeCu2 xCoxSi2 by susceptibility and resistance studies. PMID- 9942112 TI - Specific-heat behavior across the heavy-fermion to mixed-valence transition in CeCu2-xNixSi2 alloys. PMID- 9942113 TI - Hall effect in a three-dimensional percolation system. PMID- 9942114 TI - Anisotropy-induced phase transition in metallic spin-glass alloys. PMID- 9942115 TI - Ground-state zero-field splitting for the Fe3+ ion in a cubic field. PMID- 9942116 TI - Magnons and solitons in a spin-1 antiferromagnetic Heisenberg-Ising ring. PMID- 9942117 TI - Limit of ergodicity in dipolar glasses. PMID- 9942118 TI - Reply to "Limit of ergodicity in dipolar glasses" PMID- 9942119 TI - Conductivity of hierarchical networks with a broad distribution of resistors. PMID- 9942120 TI - Dynamic modes of one-dimensional Josephson tunnel junctions. PMID- 9942121 TI - Analytic solutions for bunched two-fluxon states in Josephson transmission lines. PMID- 9942122 TI - Electrical, structural, and superconducting properties of hydrogenated Nb-Ta superlattices. PMID- 9942123 TI - Photoemission resonances of the high-temperature superconductor Ba2YCu3O7+x. PMID- 9942124 TI - Confirmation of antiferromagnetism in La2CuO PMID- 9942125 TI - Antiferromagnetism and oxygen deficiency in single-crystal La2CuO4- delta. PMID- 9942126 TI - Superconducting shells in ceramic YBa2Cu PMID- 9942128 TI - Independent superconductivity and paramagnetism in HoBa2Cu3Oz. PMID- 9942127 TI - Thermodynamic fluctuations in the superconductor Y1Ba2Cu3O9- delta : Evidence for three-dimensional superconductivity. PMID- 9942129 TI - Magnetic properties of a high-Tc superconductor YBa2Cu3O7: Reentry-like features, paramagnetism, and glassy behavior. PMID- 9942130 TI - Tunneling measurements on the high-Tc superconductors La1.85Sr PMID- 9942131 TI - Far-infrared spectra of polycrystalline Ba2YCu3O9- delta. PMID- 9942132 TI - Cu-O vibrations of Ba2YCu PMID- 9942134 TI - Mean-field theory of high-Tc superconductivity: The superexchange mechanism. PMID- 9942133 TI - Superconductivity transition temperature enhancement due to Peierls instability. PMID- 9942135 TI - Structural chemistry and high-temperature superconductivity. PMID- 9942137 TI - Prediction of ferromagnetism in bcc Mn. PMID- 9942136 TI - Plasma oscillations in heavy-fermion materials. PMID- 9942139 TI - Negative evidence for a proton-tunneling mechanism in the phase transition of KH2PO4-type crystals. PMID- 9942138 TI - Switching time in Rb2(1-x)K2xZnCl4. PMID- 9942140 TI - Crossover from singular to regular thermodynamic behavior of fluids in the critical region. PMID- 9942142 TI - Positron work function and deformation potential. PMID- 9942141 TI - Propagating spin waves in Ni above Tc: Evidence against their existence. PMID- 9942144 TI - Improved age-diffusion model for low-energy electron transport in solids. II. Application to secondary emission from aluminum. PMID- 9942143 TI - Improved age-diffusion model for low-energy electron transport in solids. I. Theory. PMID- 9942145 TI - Mossbauer study of CuCr0.1Fe PMID- 9942147 TI - Silicon amorphization during ion implantation as a thermal phenomenon. PMID- 9942146 TI - Energy-transfer mechanisms in the KCl:Eu2+,Mn2+ system. PMID- 9942148 TI - Self-consistent medium polarization in spin-polarized 3He. PMID- 9942149 TI - Spin-orbit coupling in Fermi-liquid theory. PMID- 9942150 TI - Variational theory of multicomponent quantum fluids: An application to positron electron plasmas at T=0. PMID- 9942152 TI - Integrable narrow-band model with possible relevance to heavy-fermion systems. PMID- 9942151 TI - Role of final-state interactions in the inelastic structure function of quantum liquids. PMID- 9942154 TI - Near-equilibrium desorption of helium films. PMID- 9942153 TI - Behavior of anisotropic superconductors under uniaxial stress. PMID- 9942155 TI - New phonon structures observed by tunneling in granular NbN films. PMID- 9942157 TI - Brillouin-Wigner theory of mixed-valence rare-earth impurities in Bardeen-Cooper Schrieffer superconductors. PMID- 9942156 TI - Stability of the McCumber curve for long Josephson tunnel junctions. PMID- 9942158 TI - Anisotropy and drift of a vortex tangle in helium II. PMID- 9942159 TI - Thermodynamics in very strong coupling: A possible model for the high-Tc oxides. PMID- 9942160 TI - X-ray-absorption studies of YBa2Cu PMID- 9942162 TI - X-ray-absorption near-edge-structure study of La2-x(Ba,Sr)xCuO4-y superconductors. PMID- 9942161 TI - Effect of magnetic impurities on high-temperature superconductivity in La1.85Sr0.15CuO4. PMID- 9942163 TI - Normal-state reflectivity and superconducting energy-gap measurement of La2 xSrxCuO4. PMID- 9942165 TI - Pressure dependence of high-Tc superconductors. PMID- 9942164 TI - High-field measurements on the high-Tc superconductors La1.85Sr0.15CuO4- delta and YBa2Cu3O7- delta. PMID- 9942166 TI - Critical theory of quantum spin chains. PMID- 9942167 TI - Quasiparticle band structure of ferromagnetic EuS. PMID- 9942168 TI - Neutron diffraction study of PuSb: The critical regime. PMID- 9942169 TI - Polarization-analysis study of the atomic and spin-pair correlations in Ni0.76Mn0.24. PMID- 9942171 TI - Anisotropic growth rate of rough crystal faces. PMID- 9942170 TI - Magnetic behavior of the diluted magnetic semiconductor (Zn1-xMnx)3As2. PMID- 9942173 TI - Domain-wall interactions. II. High-order phases in the axial next-nearest neighbor Ising model. PMID- 9942172 TI - Crystal electric fields in heavy-electron metals: The specific heats of U2Zn17 and CeCu6 to 70 K. PMID- 9942174 TI - Domain-wall interactions. III. High-order phases in the three-state chiral-clock model. PMID- 9942176 TI - Critical dynamics of random-field Ising systems with conserved order parameter. PMID- 9942175 TI - Gapless phasons and transverse sound-wave asymmetries in K2SeO PMID- 9942178 TI - Nuclear-spin-lattice relaxation and magnetization of the ferromagnetic S=(1/2 chain system (C6H11NH3)CuBr3: Contribution of magnons and solitons. PMID- 9942177 TI - p-spin-interaction spin-glass models: Connections with the structural glass problem. PMID- 9942179 TI - Size and location of the largest current in a random resistor network. PMID- 9942180 TI - Long-range Coulomb interactions and the specific heat of the large-degeneracy version of the lattice Anderson model. PMID- 9942181 TI - Weak-localization effects in V1-xSix amorphous alloys with high Si content. PMID- 9942182 TI - Site-diagonal T-matrix expansion for anisotropic transport and percolation on bond-disordered lattices. PMID- 9942183 TI - Electronic structure, magnetic behavior, and stability of Ni-P. PMID- 9942184 TI - Reversed-spin excitations of the fractionally quantized Hall effect from finite size calculations. PMID- 9942185 TI - Improved cluster variation approximations by extension of local thermodynamic states. PMID- 9942186 TI - Long-range order in V2H near the beta - epsilon phase transition. PMID- 9942188 TI - Effects of quasiparticle screening on collective modes: Incommensurate charge density-wave systems. PMID- 9942187 TI - Observation of the highest ground-state magnetic moment of Ce in CeSi: Possibility of a quartet ground state. PMID- 9942189 TI - Ising spin system on the Fibonacci chain. PMID- 9942191 TI - Electronic structure and magnetic behavior of UMn2 and UFe2. PMID- 9942190 TI - New spin model for the biased self-avoiding walk. PMID- 9942193 TI - Surface effects on the melting transition. PMID- 9942192 TI - Variational approach to the thermodynamics of a quantum sine-Gordon field with out-of-plane fluctuations. PMID- 9942194 TI - Ground-state phases of polarized deuterium species. PMID- 9942196 TI - Surface magnons for ferromagnets with single-ion uniaxial anisotropy. PMID- 9942195 TI - Nonuniform magnetism and spin-glass properties of an Al-Mn-Si quasicrystal. PMID- 9942197 TI - Field-theoretic formulation of the Anderson transition in a magnetic field. PMID- 9942198 TI - Critical magnetization at antiphase boundaries of magnetic binary alloys. PMID- 9942199 TI - Ground state of the PMID- 9942201 TI - Acoustic C PMID- 9942200 TI - Chevrel-phase superconductor: Lattice-dynamical calculations. PMID- 9942202 TI - Superhyperfine structure of the H2- ion in MgO. PMID- 9942204 TI - Thermoelectric power of Y-Ba-Cu-O and Eu-Y-Ba-Cu-O. PMID- 9942203 TI - Temperature dependence of the elastic modulus of polycrystalline BaPb1-xBixO3. PMID- 9942205 TI - Photoemission search for the superconducting energy gap of high-TcYBa PMID- 9942206 TI - Measurement of the energy gap of YBa2Cu PMID- 9942207 TI - Crystallographic phases and transport properties in the superconducting Tm-Ba-Cu O compound system. PMID- 9942209 TI - Two-particle-resonance pairing mechanism of oxide superconductivity. PMID- 9942208 TI - Raman detection of the superconducting gap in Ba-Y-Cu-O superconductors. PMID- 9942210 TI - Crystal structure of the high-Tc superconductor Ba2YCu PMID- 9942211 TI - Pressure dependence of the Tc of YBa2Cu PMID- 9942213 TI - Magnetic x-ray scattering measurements on MnF2. PMID- 9942212 TI - Tunneling systems in superconducting YBa2Cu3O7. PMID- 9942214 TI - Crossover effects in a spin-(1/2 antiferromagnetic Heisenberg-Ising ring. PMID- 9942215 TI - Mills's model of a surface spin-flop transition. PMID- 9942216 TI - New phase diagram for the two-dimensional Coulomb gas. PMID- 9942217 TI - Universal conductance fluctuations as a probe of chaotic behavior in mesoscopic metallic spin glasses. PMID- 9942218 TI - Wetting on a spherical surface. PMID- 9942219 TI - Multifractal structure of the incipient infinite percolating cluster. PMID- 9942220 TI - Multifractal analysis of fluctuations for wave functions localized by disorder. PMID- 9942221 TI - Generalized effective-medium approximation for particle transport. PMID- 9942222 TI - Spin-fracton effects in dilute amorphous alloys. PMID- 9942223 TI - Accelerated dynamics in simulations of first-order phase transitions. PMID- 9942225 TI - Scatter-matrix approach to quantum transport. PMID- 9942224 TI - Raman studies on potassium-ammonium dihydrogen phosphate systems PMID- 9942226 TI - Observation of elastic scattering of positrons and electrons at glancing incidence. PMID- 9942227 TI - Weak localization and the conductivity of nondegenerate electrons. PMID- 9942228 TI - Strong-coupling calculation of the lower critical field in high-Tc superconductors. PMID- 9942229 TI - Domainlike defects observed in the high-temperature superconductor Y-Ba-Cu-O. PMID- 9942230 TI - Observed trends in the x-ray photoelectron and Auger spectra of high-temperature superconductors. PMID- 9942231 TI - Electronic transport in highly-doped La2-xSrxCuO4 superconductors. PMID- 9942232 TI - Thermal transport properties of YBa2Cu PMID- 9942233 TI - Thermal properties of the high-Tc superconductors La1.85Sr0.15CuO4 and YBa2Cu3O7. PMID- 9942235 TI - Nuclear quadrupole resonance and nuclear magnetic resonance of copper in the high Tc superconductor YBa2Cu PMID- 9942234 TI - Synchrotron-radiation photoemission study of the high-Tc superconductor YBa2Cu PMID- 9942236 TI - Superconductivity in HxYBa PMID- 9942237 TI - Ultrasonic attenuation and pore microstructure in a liquid-4He-filled ceramic. PMID- 9942238 TI - Temperature dependence of La spin-lattice relaxation time in the high-Tc superconductor La1.85Sr PMID- 9942239 TI - Fermi-liquid scaling in the paramagnetic spectral response of the compounds CeSn3 xInx. PMID- 9942240 TI - Stability analysis of special-point ordering in the basal plane of YBa2Cu PMID- 9942241 TI - Low-temperature structural phase transition in La2CuO PMID- 9942242 TI - Effect of nominal composition on the superconductivity in La2CuO4-y. PMID- 9942243 TI - Single-phase 60-K bulk superconductor in annealed Ba2YCu PMID- 9942244 TI - High-temperature order-disorder phase transition in the superconductor Y1Ba PMID- 9942246 TI - Structural and superconducting properties of orthorhombic and tetragonal YBa2Cu PMID- 9942245 TI - Nuclear magnetic resonance and nuclear quadrupole resonance study of copper in Ba2YCu PMID- 9942248 TI - Evolution of heavy-fermion behavior from mixed-valence state in the series Ce(Pt1 xNix)Si. PMID- 9942247 TI - Far-infrared composite-medium study of sintered La2NiO PMID- 9942250 TI - Spin-glass transition in three-dimensional random-anisotropy-axis model. PMID- 9942249 TI - Magnetic excitations and phonon anomalies in URu2Si PMID- 9942251 TI - Calorimetric investigations of scaling behavior in aluminosilicate spin glasses. PMID- 9942252 TI - Internal diffusion noise of fractals. PMID- 9942253 TI - Submonolayers of paramagnetic NO2 adsorbed on argon and xenon films. PMID- 9942254 TI - Renormalization-group treatment of the long-ranged one-dimensional Ising model with random fields. PMID- 9942255 TI - Surface segregation at metalndashIII-V-compound-semiconductor interfaces. PMID- 9942256 TI - Universal features of hydrogen absorption in amorphous transition-metal alloys. PMID- 9942257 TI - Quantum transport for a many-body system using a quantum Langevin-equation approach. PMID- 9942258 TI - High-resolution photoemission study of the electronic structure of the noble metal (111) surfaces. PMID- 9942260 TI - Modified method of variational calculations of Wannier functions: The Wannier functions for d bands of Cu and paramagnetic Ni. PMID- 9942259 TI - Adsorbate effects on a mixed-valence compound: Carbon monoxide chemisorption on CeIr2. PMID- 9942261 TI - Two-dimensional Yb on a Mo(110) surface. PMID- 9942263 TI - Relativistic screened orbital radii. PMID- 9942262 TI - Vibrational properties of beta 1-H and beta 1-D on W(001): Electron-energy-loss measurements and lattice-dynamical calculations. PMID- 9942264 TI - Dynamics of dense lattices. PMID- 9942265 TI - Resistance of a one-dimensional quasicrystal: Power-law growth. PMID- 9942267 TI - Measurement of the grain-boundary states in semiconductors by deep-level transient spectroscopy. PMID- 9942266 TI - Hole subbands in strained GaAs-Ga1-xAlxAs quantum wells: Exact solution of the effective-mass equation. PMID- 9942268 TI - Electronic and vibronic structure of the (GaAs)1(AlAs)1 superlattice. PMID- 9942269 TI - Physical nature of the InP near-surface defect acceptor and donor states. PMID- 9942271 TI - Screening of shallow impurities in germanium within the local-density approximation. PMID- 9942270 TI - Heterojunction band offsets and the interface dielectric function. PMID- 9942272 TI - Infrared absorption in Cd1-xMnxTe: Bound-magnetic-polaron effects on the photoionization of acceptors. PMID- 9942273 TI - Electron-induced extended-fine-structure measurements of thin-film growth and reaction. PMID- 9942274 TI - Elementary electronic excitations in a quasi-two-dimensional electron gas. PMID- 9942276 TI - Magnetoplasmons in thin films in the Voigt configuration. PMID- 9942275 TI - Scattering states and distribution functions for microstructures. PMID- 9942278 TI - Surface electronic structure of Si(111)7 x 7-Ge and Si(111)5 x 5-Ge studied with photoemission and inverse photoemission. PMID- 9942277 TI - Electronic structure of Pb1-xSnxTe semiconductor alloys. PMID- 9942279 TI - Temperature dependence of hyperfine coupling of the anion antisite in III-V compounds. PMID- 9942280 TI - Ionized-impurity scattering in the strong-screening limit. PMID- 9942281 TI - Electron-diffraction study of rubidium-intercalated graphite. PMID- 9942283 TI - Monte Carlo investigation of the electron-hole-interaction effects on the ultrafast relaxation of hot photoexcited carriers in GaAs. PMID- 9942282 TI - Inversion asymmetry in Hg1-xMnxSe. PMID- 9942285 TI - Triplet excitations in conjugated polymers. PMID- 9942286 TI - Phonon shifts and widths in dilute elemental semiconducting alloys. PMID- 9942284 TI - Theoretical analysis of plasmon, polar phonon, and hot-electron energy relaxation in nondegenerate semiconductors. PMID- 9942288 TI - Theoretical study of BN, BP, and BAs at high pressures. PMID- 9942287 TI - Resonant Raman scattering in GaAs-Ga1-xAlxAs quantum wells in an electric field. PMID- 9942289 TI - Propagating two-dimensional density fluctuations in the graphite intercalate C36Cs. PMID- 9942290 TI - Surface states and the exponential valence-band tail in a-Si:H. PMID- 9942291 TI - Tunneling microscopy of Ge(001). PMID- 9942292 TI - Free, quasifree, momentarily trapped, and self-trapped exciton states in molecular crystals. PMID- 9942293 TI - Excitons and biexcitons in semiconductor quantum wires. PMID- 9942294 TI - Bulk and surface electronic structure of hexagonal boron nitride. PMID- 9942295 TI - Interatomic Auger rates for the sodium fluoride crystal. PMID- 9942296 TI - Optical detection of a hydrogen complex responsible for the F phosphorescence in thermochemically reduced MgO crystals. PMID- 9942298 TI - Optical properties of GeO2. PMID- 9942297 TI - Analysis of the off-center effect of Cu+ in alkali halides using crystal-field theory. PMID- 9942299 TI - Tight-binding calculation of surface defects in SrTiO3. PMID- 9942301 TI - Trapping and oxidation of CO at surface step sites of MgO. PMID- 9942300 TI - Confined optical phonons in a GaAs single quantum well in a GaAs/AlxGa PMID- 9942302 TI - Interpolative solution for the Anderson model of an impurity. PMID- 9942303 TI - Enhancement of nonparabolicity effects in a quantum well. PMID- 9942304 TI - Stability and electronic structure of ultrathin-layer superlattices: (GaAs)n/(AlAs)n. PMID- 9942306 TI - Search for electric echoes in K0.3MoO PMID- 9942305 TI - Unoccupied surface-state band on Si(111) 2 x 1. PMID- 9942307 TI - Structure of the asymptotic exchange hole. PMID- 9942308 TI - Comment on the application of Kimball's formula for small values of rs. PMID- 9942309 TI - Reply to "Comment on the application of Kimball's formula for small values of rs" PMID- 9942310 TI - One-dimensional electron-phonon problem. PMID- 9942311 TI - Erratum: Piezoelectricity and flexoelectricity in crystalline dielectrics PMID- 9942312 TI - Spin-aligned momentum distributions of transition-metal ferromagnets studied with circularly polarized synchrotron radiation. PMID- 9942313 TI - Spin-dependent electron interactions in metals across the compressibility and spin-susceptibility anomalies. PMID- 9942315 TI - Lattice-dynamical analysis of the anomalous mode of W(001). PMID- 9942314 TI - Temperature-dependent surface morphology of Au/Cu(001). PMID- 9942316 TI - Scanning-tunneling microscopy at small tip-to-surface distances. PMID- 9942318 TI - Photoelectron paramagnetic resonance of Pt- in silicon. PMID- 9942317 TI - ESR linewidth behavior for barely metallic n-type silicon. PMID- 9942320 TI - Model for the energetics of Si and Ge (111) surfaces. PMID- 9942319 TI - Nonuniformity in void concentration between the initial and final growth stage of sputtered a-Ge films studied using spectroscopic ellipsometry. PMID- 9942321 TI - Cs and O adsorption on Si(100)2 x 1: A model system for promoted oxidation of semiconductors. PMID- 9942322 TI - Creation of near-interface defects in hydrogenated amorphous silicon-silicon nitride heterojunctions: The role of hydrogen. PMID- 9942323 TI - Indium-induced reconstructions of the Si(111) surface studied by scanning tunneling microscopy. PMID- 9942324 TI - New path-integral solution for the density of states of two-dimensional electrons in high magnetic fields. PMID- 9942325 TI - Hydrogen passivation of shallow acceptors in c-Si: An ab initio approach. PMID- 9942326 TI - Room-temperature growth of two-dimensional gold films on GaAs(001). PMID- 9942328 TI - Investigation of paraexcitons in KI. PMID- 9942327 TI - Picosecond dynamics of band-edge photoexcitation in trans-polyacetylene. PMID- 9942329 TI - Diffusive traversal time: Effective area in magnetically induced interference. PMID- 9942330 TI - Long-wavelength limit of the optical response of a metal surface. PMID- 9942331 TI - Optical response of nonlinear multilayer structures: Bilayers and superlattices. PMID- 9942332 TI - Electronic excited-state transport with infrared divergence in disordered systems. PMID- 9942333 TI - Strain-induced surface segregation and ordering in pseudomorphic metal-alloy overlayers. PMID- 9942334 TI - Adsorption-induced surface core-level shifts of Pt(110). PMID- 9942336 TI - Functional-integral approach to the polaron mass. PMID- 9942335 TI - Hypernetted-chain approximation and quasiparticle energies in the (1/3 fractional quantized Hall effect. PMID- 9942338 TI - Surface plasmons in two-sided corrugated thin films. PMID- 9942337 TI - Theoretical computation of coherent scattering intensities, partial structure factors, and diffusion coefficients of magnesium-bismuth melt. PMID- 9942339 TI - Surface effects in metal microclusters. PMID- 9942340 TI - New realization of the Pippard condition: Inelastic electron-impurity scattering for crystalline alloys at very low temperatures. PMID- 9942341 TI - Energy-band structure of NbC studied with angle-resolved photoelectron spectroscopy. PMID- 9942342 TI - Self-consistent calculations using canonical scaling in the linearized atomic cell orbital method: Energy bands of fcc Cu. PMID- 9942343 TI - Empty-lattice test of the linearized atomic-cell orbital method for energy bands. PMID- 9942344 TI - Perturbation-theoretic studies of the anomalous electronic structure and transport properties of quasicrystals. PMID- 9942345 TI - Treatment of lattice relaxations in dilute alloys within the Korringa-Kohn Rostoker Green's-function method. PMID- 9942346 TI - Photoemission study of the valence-band satellite of Ni(110). PMID- 9942347 TI - Chemisorption processes of transition metals Ti, Cr, and Fe on a Si(111) surface. PMID- 9942348 TI - Linear augmented Slater-type orbital study of Pt-5d-transition-metal alloying. PMID- 9942349 TI - Theory of second-harmonic generation by metal overlayers. PMID- 9942350 TI - Thermoelectric power of TiS2. PMID- 9942352 TI - Multiple-scattering effects in the K-edge x-ray-absorption near-edge structure of crystalline and amorphous silicon. PMID- 9942351 TI - Te and Cd nuclear-magnetic-resonance study of local structure and bonding in Cd1 xZnxTe. PMID- 9942353 TI - New classical models for silicon structural energies. PMID- 9942355 TI - Effects of cation vacancies and diffusion on the surface states of Hg1-xCdxTe. PMID- 9942354 TI - High-field transport phenomenology: Hot-electron generation at semiconductor interfaces. PMID- 9942356 TI - Electron transport in a one-side-modulation-doped single-quantum-well structure: Remote-ion-scattering contribution. PMID- 9942358 TI - Effect of interplane coupling on the quantized Hall effect in multilayer structures. PMID- 9942357 TI - Doping and annealing effects on persistent photoconductivity in doping-modulated amorphous-silicon superlattices. PMID- 9942359 TI - Trends in self-energy operators and their corresponding exchange-correlation potentials. PMID- 9942360 TI - Critical plasmons of a Fibonacci semiconductor superlattice: Spectrum and optical properties. PMID- 9942361 TI - Persistent photocurrent decay mechanisms by capture of photoelectrons in GaAs AlxGa1-xAs heterostructures. PMID- 9942362 TI - Ab initio linear combination of pseudo-atomic-orbital scheme for the electronic properties of semiconductors: Results for ten materials. PMID- 9942363 TI - Ion-channeling determination of the atomic-site location of antimony at the (111) silicon-silicon dioxide interface. PMID- 9942365 TI - Surface shifts in the In 4d and P 2p core-level spectra of InP(110). PMID- 9942364 TI - Vibrational spectrum of amorphous silicon: Experiment and computer simulation. PMID- 9942366 TI - Inclusion of collision broadening in semiconductor electron-transport simulations. PMID- 9942368 TI - Angle-resolved inverse photoelectron spectroscopy studies of CdTe(110), CdS(112 bar0), and CdSe(112-bar0). PMID- 9942367 TI - Phonon scattering at silicon crystal surfaces. PMID- 9942369 TI - Axial approximation in the calculation of the valence bands in semiconductor superlattices. PMID- 9942371 TI - Phase diagram and local correlations in pseudobinary alloys. PMID- 9942370 TI - Differential spectroscopy of GaAs-Ga1-xA PMID- 9942373 TI - Magnetoplasmons in tunneling semiconductor superlattices. PMID- 9942372 TI - Electronic structure of superlattices and quantum wells under uniaxial stress. PMID- 9942374 TI - Quantum kinetic equation for electronic transport in nondegenerate semiconductors. PMID- 9942375 TI - Energy shift and line broadening of three-dimensional excitons in electric fields. PMID- 9942376 TI - Influence of doping on the etching of Si(111). PMID- 9942377 TI - Temperature-dependent interface evolution for Ti/GaAs(100) and Cr/GaAs(100). PMID- 9942378 TI - Theory of the structural phase transition of GeTe. PMID- 9942379 TI - Equation-of-motion method for the study of defects in insulators: Application to a simple model of TiO2. PMID- 9942380 TI - Thermally stimulated luminescence and its related thermally stimulated currents in quartz. PMID- 9942381 TI - Inelastic electron-tunneling studies of the effect of hydrogen on the growth of MgO. PMID- 9942382 TI - Diffusivity and neutron scattering study of the Li-defect conversion in MgF2. PMID- 9942383 TI - Inelastic phonon scattering in LaF3 by resonant Raman processes. PMID- 9942384 TI - Determination of structural instabilities of atomic lattices by means of a Monte Carlo simulation. PMID- 9942385 TI - Electron correlations in semiconductor heterostructures. PMID- 9942386 TI - Co/Si(111) interface formation at room temperature. PMID- 9942388 TI - Ground-state splitting of the 78-meV double acceptor in GaAs. PMID- 9942387 TI - Effects of dihedral-angle disorder on the density of states of a-Si and a-Ge. PMID- 9942389 TI - Electronic structure of FexO. PMID- 9942391 TI - Anderson transition in the presence of the spin-orbit interaction: A crossover calculation. PMID- 9942390 TI - Observation of a dynamical propensity rule in rotationally inelastic gas-surface scattering: NH3 on Au(111). PMID- 9942393 TI - Optical response of an embedded atom: Resonant photoemission from uranium. PMID- 9942392 TI - Melting and nonmelting behavior of the Au(111) surface. PMID- 9942394 TI - Complete excitation spectrum for a charge-density-wave system. PMID- 9942395 TI - General relation between band-gap renormalization and carrier density in two dimensional electron-hole plasmas. PMID- 9942396 TI - Spectroscopy and four-wave mixing in Lisub4Ge PMID- 9942397 TI - Analysis of electron-energy-loss spectrum of Na on solid Cu: Cluster-model approach. PMID- 9942399 TI - Depression of the superconducting transition temperature by magnetic impurities: Effect of Kondo resonance in the f density of states. PMID- 9942398 TI - Positron-trapping mechanism at dislocations in Zn. PMID- 9942400 TI - Driven, dissipative superfluids: Radial counterflow of rotating 4He. PMID- 9942401 TI - Resonant scattering and Anderson localization of acoustic waves. PMID- 9942402 TI - Singular gradient free energy of superfluid 3He-A at T=0. PMID- 9942404 TI - Static and dynamic magnetic properties of 3He confined by fluorocarbon microspheres. PMID- 9942405 TI - Compression of spin-polarized hydrogen bubbles to thermal explosion. PMID- 9942403 TI - Experiments with supercooled liquid hydrogen. PMID- 9942406 TI - Current-voltage characteristics in collective pinning. PMID- 9942407 TI - Nuclear specific heat of bcc 3He near the magnetic ordering transitions. PMID- 9942408 TI - Satellite magnetic resonances of a bound pair of half-quantum vortices in rotating superfluid 3He-A. PMID- 9942409 TI - Resonance Raman investigations of the symmetric stretching mode of I3 - anions in alpha and beta phases of di-bis(ethylenedithio)tetrathiafulvalene tri-iodide. PMID- 9942410 TI - Tunneling and activated motion of a string across a potential barrier. PMID- 9942411 TI - Electronic structure of oxygen-deficient high-Tc superconductors: YBa2Cu PMID- 9942412 TI - Specific heat of GdBa2Cu3O7- delta in the normal and superconducting states. PMID- 9942413 TI - Nonlinear internal dynamics of the double-sine-Gordon soliton. PMID- 9942414 TI - Lattice-gas melting of two-dimensional alloys: Application to ternary graphite intercalation compounds. PMID- 9942415 TI - Model calculations of phase diagrams of magnetic alloys on the body-centered cubic lattice. PMID- 9942417 TI - Susceptibility and correlation functions in amorphous magnets. PMID- 9942416 TI - Magnetoquantum oscillations, magnetic breakdown, and Fermi-surface modifications in NbSe3. PMID- 9942419 TI - Simulated growth of wetting layers. PMID- 9942418 TI - Origin and orientation of the electric field gradient in ordered FeNi. PMID- 9942420 TI - Two-dimensional structural phase transitions in the stage-1 OsF6-graphite intercalated compound. PMID- 9942421 TI - Specific heat and collapse transition of branched polymers. PMID- 9942422 TI - Spin dynamics of YH2 and YD2. PMID- 9942424 TI - X-ray study of the modulation-wave structure in thiourea. PMID- 9942423 TI - Polariton and effective-medium theory of magnetic superlattices. PMID- 9942425 TI - Magnetic behavior of the diluted magnetic semiconductor Zn1-xMnxSe. PMID- 9942427 TI - Role of activated processes and boundary conditions in the domain growth of the Potts model. PMID- 9942426 TI - Magnons and fractons in the diluted antiferromagnet MnxZn PMID- 9942429 TI - Ordering in quasi-two-dimensional planar ferromagnets: A neutron scattering study of graphite intercalation compounds. PMID- 9942428 TI - Tiling model for glass formation with incremental domain-size kinetics. PMID- 9942430 TI - Thermomagnetic transport coefficients: Solitons in an easy-plane magnetic chain. PMID- 9942432 TI - Wetting in fcc Ising antiferromagnets and binary alloys. PMID- 9942431 TI - Ferromagnetic resonance method for determining the magnetic surface anisotropy of amorphous films. PMID- 9942433 TI - Alternative transfer-matrix approach to two-dimensional systems with competing interactions in one direction. PMID- 9942434 TI - Conformational disorder in the premelting phases of linear polymer layers. PMID- 9942435 TI - Trapping of nonthermal positrons in metals. PMID- 9942437 TI - Role of anharmonicity in the high-Tc superconductors. PMID- 9942436 TI - Electronic structure and properties of quasi-two-dimensional layered superconducting perovskites: La2-xMxCuO4 (M=Ba, Sr,.). PMID- 9942438 TI - Oxygen-vacancy ordering in the Ba2YCu PMID- 9942440 TI - Reexamination of the Y2O3-BaO-CuO phase diagram for solid solutions near Y1Ba2Cu3O7. PMID- 9942439 TI - Investigation of the energy gap of Y-Ba-Cu-O by point-contact Josephson-junction techniques. PMID- 9942441 TI - Possible Josephson oscillations spectra and electron paramagnetic resonance of Cu2+ in Y-Ba-Cu-O. PMID- 9942443 TI - Effects of oxygen deficiency on the infrared spectra in YBa2Cu3O7- delta. PMID- 9942442 TI - Low-dimensional magnetism in the high-Tc superconductor LBa PMID- 9942444 TI - Phonon density of states of the YBa2Cu PMID- 9942445 TI - Polarization-induced pairing in high-temperature superconductivity. PMID- 9942446 TI - Specific heat near TN in (Pr, Nd, Sm, Gd, and Dy)Ba2Cu3O7: Evidence for spin exchange-driven ordering. PMID- 9942447 TI - Observation of carboxylic groups in the lattice of sintered Ba2YCu3O7-y high-Tc superconductors. PMID- 9942449 TI - Magnetoresistive effects in the upper critical fields of heavy-fermion superconductors. PMID- 9942448 TI - Enhanced critical magnetization currents due to fast neutron irradiation in single-crystal YBa2Cu3O7- delta. PMID- 9942450 TI - New method for measuring induced magnetic anisotropy: Application to kinetic studies. PMID- 9942452 TI - Critical behavior of the N-component Ashkin-Teller model with bond impurities. PMID- 9942451 TI - Asymmetric Baxter phase in the symmetric Ashkin-Teller model. PMID- 9942453 TI - Effect of an applied electric field upon one-dimensional localization. PMID- 9942454 TI - Electronic properties of a one-dimensional hierarchical system. PMID- 9942455 TI - Chiral order in a two-dimensional XY spin glass. PMID- 9942456 TI - Evidence of memory effects in a commensurate ferroelectric phase. PMID- 9942457 TI - Erratum: d-orbital theory and high-pressure effects upon the EPR spectrum of ruby PMID- 9942459 TI - Erratum: Longitudinal spin susceptibility and spin dynamics o field-induced spin density waves in Bechgaard salts PMID- 9942458 TI - Erratum: Classification of octahedral tilting phases in the perovskitelike A2BX4 structure PMID- 9942461 TI - Valence-bond approach to two-dimensional broken symmetries: Application to La2CuO4. PMID- 9942460 TI - Fluxoid quantization in the resonating-valence-bond model. PMID- 9942463 TI - Structural basis for enhanced Tc in YBa2Cu3OyFx. PMID- 9942462 TI - Low-temperature neutron irradiation effects on superconducting Y-Ba-Cu oxides. PMID- 9942464 TI - Electrical properties of high-Tc superconducting single-crystal Eu1Ba2Cu3Oy. PMID- 9942466 TI - Energy gap and critical temperature in a resonating-valence-bond theory of high Tc superconductivity. PMID- 9942465 TI - Theoretical calculation of optical properties of Y-Ba-Cu-O superconductors. PMID- 9942467 TI - Current transport in high-Tc polycrystalline films of Y-Ba-Cu-O. PMID- 9942468 TI - Superconductivity in La-deficient and stoichiometric La2CuO PMID- 9942470 TI - Variation of superconductivity with carrier concentration in oxygen-doped YBa2Cu3O7-y. PMID- 9942469 TI - Raman study of La2CuO4: Possibility of local symmetry breaking. PMID- 9942471 TI - Indication of high local fields in the YBa2Cu2.9375Be0.0625O delta superconductor by Mossbauer spectroscopy. PMID- 9942472 TI - Susceptibility, crystal-structure, and Mossbauer study of the high-temperature superconductor YBa2Cu3O7- delta doped with iron. PMID- 9942474 TI - Nature of the pairing in a resonating-valence-bond superconductor. PMID- 9942473 TI - Antiferromagnetic order in DyBa2Cu PMID- 9942475 TI - Low-field microwave absorption in the superconducting copper oxides. PMID- 9942477 TI - Electronic properties of oxygen vacancies in La2CuO4-y. PMID- 9942476 TI - Current persistence and magnetic shielding properties of Y1Ba2Cu3Ox tubes. PMID- 9942478 TI - Direct evidence of the importance of electron-phonon coupling in La2CuO PMID- 9942479 TI - Observation of the thermal diffuse scattering in La2-xMxCuO4 (M=Sr,Ba). PMID- 9942480 TI - Normal-state resistivity of the high-Tc compound Y1Ba2Cu3O7- delta. PMID- 9942481 TI - Effect of oxygen desorption on electrical transport in YBa2Cu3O7- delta. PMID- 9942482 TI - Electron paramagnetic resonance of Gd3+ ions in the superconductor GdBa2Cu3Ox. PMID- 9942483 TI - Resistive transition and magnetic field response of a Penrose-tile array of weakly coupled superconductor islands. PMID- 9942484 TI - Suppression of superconductivity by antiferromagnetism in Tm2Fe PMID- 9942486 TI - Particle-size effect on the conductivity of dispersed ionic conductors. PMID- 9942485 TI - Observation of Al2O3:Cr3+ magnetic resonance via solitons in long Josephson junctions. PMID- 9942487 TI - Critical behavior of the Hall conductivity near the percolation threshold in granular Sn:Ar mixtures. PMID- 9942488 TI - Neutron scattering study of magnetic excitations in intercalated CoCl2. PMID- 9942489 TI - Critical-point dewetting. PMID- 9942490 TI - Sine-wave-to-helimagnetic transition in phosphorus-rich Eu(As1-xPx PMID- 9942491 TI - Two-dimensional ferromagnetic correlations in CoCl2-intercalated graphite. PMID- 9942492 TI - Continued exploration of the wetting phase diagram. PMID- 9942493 TI - Commensurate-incommensurate and rotational transitions of monolayer xenon on single-crystal graphite. PMID- 9942494 TI - Dynamics of fluctuations in the ordered phase of kinetic Ising models. PMID- 9942495 TI - Equilibrium properties of hcp titanium and zirconium. PMID- 9942496 TI - Electronic structure of a two-dimensional Penrose lattice: Single- and two component systems. PMID- 9942498 TI - Existence of Wannier-Stark localization. PMID- 9942497 TI - Comparison of the icosahedral and alpha structures of Al-Mn-Si with the use of soft-x-ray emission spectroscopy. PMID- 9942499 TI - Electronic properties of Nb and H-treated Nb surfaces. PMID- 9942501 TI - NiAl(110) surface: First-principles determination of the rippled relaxation. PMID- 9942500 TI - Estimate of repulsive interatomic pair potentials by low-energy alkali-metal-ion scattering and computer simulation. PMID- 9942503 TI - Model studies of the chemisorption of hydrogen and oxygen on Cu(100). PMID- 9942502 TI - Dynamical screening at simple-metal surfaces. PMID- 9942504 TI - Estimation of electron-electron interaction strengths for the rare-earth metals from X alpha calculations. PMID- 9942505 TI - Transport coefficients close to the mobility edge and nonlinear sigma -model composite operators. PMID- 9942506 TI - Anomalous high-temperature hopping in metal hydrides. PMID- 9942508 TI - Correlation effects on the L3VV Auger line shape of Cd1-xMnxTe. PMID- 9942507 TI - Auger-electron-spectroscopy analysis of a plasmon loss in palladium silicide formed from Pd deposits on silicon. PMID- 9942509 TI - Polarity in semiconductor compounds. PMID- 9942510 TI - Generation of amorphous-silicon structures with use of molecular-dynamics simulations. PMID- 9942511 TI - Generalized master equations and phonon-assisted hopping. PMID- 9942512 TI - Phonon-limited mobility in a quasi-one-dimensional semiconductor. PMID- 9942513 TI - Polaronic band tails in disordered solids: Combined effects of static randomness and electron-phonon interactions. PMID- 9942515 TI - Infrared photoexcitation and doping studies of poly(3-methylthienylene). PMID- 9942514 TI - Resonant Raman scattering by plasmons and LO phonons near the E1 and E1+ Delta 1 gaps of GaSb. PMID- 9942516 TI - Ellipsometric studies of the dielectric function of SnSe and a simple model of the electronic structure and the bonds of the orthorhombic IV-VI compounds. PMID- 9942517 TI - Primary-energy dependence of the momentum transfer in reflection inner-shell electron energy-loss spectra of layered transition-metal dichalcogenides. PMID- 9942518 TI - Surface-phonon dispersion curves of TiC(100). PMID- 9942519 TI - Coupled plasmon-LO-phonon modes in GaxIn PMID- 9942520 TI - Domain structure in epitaxial metastable zinc-blende (GaAs)1-x(Ge2)x(001) alloys. PMID- 9942521 TI - Picosecond dynamics of photogenerated charged solitons in trans-polyacetylene. PMID- 9942522 TI - Localized phonons associated with solitons in polyacetylene: Coupling to the nonuniform mode. PMID- 9942523 TI - Theory of interstitial transition atoms in GaAs. PMID- 9942524 TI - Hopping conductivity in lightly doped semiconductors. I. Two dimensions. PMID- 9942525 TI - Hopping conductivity in lightly doped semiconductors. II. Three dimensions. PMID- 9942526 TI - Collective excitation spectrum of the nu =(2/5 fractionally quantized Hall state. PMID- 9942527 TI - Transient photoconductivity in amorphous silicon. PMID- 9942528 TI - Indication of universal behavior of Hall conductivity near the metal-insulator transition in disordered systems. PMID- 9942529 TI - Model adsorption potentials of rare gases on boron nitride. PMID- 9942530 TI - Possible role of charged defects in molecular solids. PMID- 9942531 TI - Nontransferable van der Waals potentials: Insulators at high pressure. PMID- 9942532 TI - Electron-diffraction study of SbCl5-intercalated graphite. PMID- 9942533 TI - Spectroscopic studies of impurity-host interactions in dye-doped polymers: Hydrostatic-pressure effects versus temperature effects. PMID- 9942534 TI - Elastic behavior under hydrostatic pressure and acoustic-mode vibrational anharmonicity of single-crystal berlinite. PMID- 9942535 TI - Thermal conductivity and specific heat of glasses. PMID- 9942536 TI - "Clustering modes" in the vibrational spectra of Hg1-xCdxTe alloys. PMID- 9942537 TI - Temperature dependence of the resistivity in polymer-conducting-carbon-black composites. PMID- 9942538 TI - Plasma modes of a two-dimensional electron gas with a two-dimensional modulation of the charge density. PMID- 9942539 TI - Evidence for LO-phonon-emission-assisted tunneling in double-barrier heterostructures. PMID- 9942541 TI - Photoemission study of Cd1-xMnxF2 with fluorite (x <= 0.1) and rutile (x >= 0.925) structures. PMID- 9942540 TI - Exchange and correlation effects on screening in a two-dimensional electron gas. PMID- 9942542 TI - Raman spectroscopy study of Al0.48In PMID- 9942543 TI - Binding energies of hydrogenic impurities in parabolic quantum wells. PMID- 9942544 TI - Anomalous displacement of excitons in a quantum well. PMID- 9942545 TI - Au/InSb(110) interface profiles from synchrotron-radiation and polar-angle dependent x-ray photoemission. PMID- 9942547 TI - High-pressure studies of NaH to 54 GPa. PMID- 9942546 TI - Chemical and electronic properties of Ga on the InP(100) surface. PMID- 9942549 TI - Reply to "Comment on 'Identification of a defect in a semiconductor: EL2 in GaAs' " PMID- 9942548 TI - Comment on "Identification of a defect in a semiconductor: EL2 in GaAs" PMID- 9942550 TI - Erratum: Estimates of the heats of adsorption for Pt and Pd monolayers on Ta(110) PMID- 9942552 TI - Validity of the static approximation in the functional-integral approach to mixed valence systems. PMID- 9942551 TI - Depth profiling of elastic strains in lattice-mismatched semiconductor heterostructures and strained-layer superlattices. PMID- 9942553 TI - Thermodynamic properties and phase diagram of icosahedral AlxLi PMID- 9942554 TI - Tunneling systems and disorder in quasicrystals. PMID- 9942556 TI - Theory of the phonons and plasmons in mercury chain compounds. PMID- 9942555 TI - Structural determination of an adsorbate-induced surface reconstruction: p4g(2 x 2)N versus c(2 x 2)O on Ni(100). PMID- 9942557 TI - Characterization of the hybridized 4f states in YbAl3 by high-energy spectroscopies. PMID- 9942558 TI - Inelastic phase-coherence time in thin metal films. PMID- 9942559 TI - Dimensionality of electron-electron scattering and interaction effects in thin wires and films. PMID- 9942560 TI - Evidence for the existence of the inherent periodicity in the switched state at low temperatures in K0.3MoO PMID- 9942561 TI - Structural model of Si(100)-c(4 x 4). PMID- 9942562 TI - Arsenic atom location on passivated silicon (111) surfaces. PMID- 9942563 TI - Structure of oxygen adsorbed on the GaAs(110) surface studied using scanning tunneling microscopy. PMID- 9942564 TI - Frohlich interaction in two-dimensional GaAs/AlxGa PMID- 9942566 TI - Two-strain mechanism of pressure-induced body-centered-tetragonal to hexagonal close-packed transition in Hg and HgxCd PMID- 9942565 TI - Photoresponse of the FR3 electron-spin-resonance signal in GaAs. PMID- 9942567 TI - Model-potential-based simulation of Si(100) surface reconstruction. PMID- 9942569 TI - Photoinduced changes of ac transport in amorphous As2S PMID- 9942568 TI - Magnetic field dependence of persistent cyclotron-resonance half-width in pure n type CdTe. PMID- 9942570 TI - New method to study band offsets applied to strained Si/Si1-xGex(100) heterojunction interfaces. PMID- 9942571 TI - Field-dependent electrical conductivity in disordered Ge1-xAux alloys. PMID- 9942572 TI - Dephasing time and one-dimensional localization of two-dimensional electrons in GaAs/AlxGa1-xAs heterostructures. PMID- 9942574 TI - Bulk and surface diffusion of heavy particles in metals: A path-integral approach. PMID- 9942573 TI - Direct evidence for efficient energy transfer from N-related defects to PGa antisite complexes in GaP from optically detected magnetic resonance. PMID- 9942575 TI - Electron and positron energy levels in solids. PMID- 9942576 TI - Optical properties of molecular conductors: One-dimensional systems with twofold commensurate charge-density waves. PMID- 9942577 TI - Electromagnetic generation of gigahertz sound in ferromagnetic metals. PMID- 9942578 TI - Thermodynamic properties of tungsten. PMID- 9942579 TI - Propagation of surface acoustic waves across random gratings. PMID- 9942580 TI - Simple model for pyroelectric luminescence. PMID- 9942582 TI - Susceptibility of the two-dimensional electron gas: Diamagnetic spikes and gaps in the density of states. PMID- 9942581 TI - Spin-resolved inverse-photoemission study of Ni(001) and its chemisorption. PMID- 9942583 TI - Effects of the phonon structure on the elastic scattering probabilities of light particles from surfaces. PMID- 9942584 TI - Low-temperature electrical resistance and magnetoresistance of disordered Cu 72Y PMID- 9942586 TI - Determination of molecular orientations on surfaces from the angular dependence of near-edge x-ray-absorption fine-structure spectra. PMID- 9942585 TI - Enhanced specific-heat-capacity (cp) measurements (150-300 K) of nanometer-sized crystalline materials. PMID- 9942587 TI - Effect of correlation on conductivity and relaxation time. PMID- 9942588 TI - Activation energies and localization in the fractional quantum Hall effect. PMID- 9942590 TI - Conductivity and quenched-in defects in hydrogenated amorphous silicon. PMID- 9942589 TI - Magneto-optical evidence of the exchange interaction in a Hg1-xMnxTe-CdTe superlattice. PMID- 9942591 TI - Optical dephasing and migration of bound excitons in GaP:N. PMID- 9942593 TI - Long-lived excitons in InAs quantum wells under uniaxial stress. PMID- 9942592 TI - Electronic properties of a (Cu-Li)-related neutral complex defect with a bound exciton at 2.25 eV in GaP. PMID- 9942595 TI - Transmission coefficient of an electron through a saddle-point potential in a magnetic field. PMID- 9942594 TI - Bipolarons in poly(3-methylthiophene): Spectroscopic, magnetic, and electrochemical measurements. PMID- 9942596 TI - Properties of a magnetopolaron at the interface of polar-polar crystals. PMID- 9942597 TI - Magnetopolaron in a semiconductor quantum well. PMID- 9942598 TI - Electronic properties of metastable GexSn PMID- 9942599 TI - Trigonal hydrogen-related acceptor complexes in germanium. PMID- 9942600 TI - Conductance fluctuations near the localized-to-extended transition in narrow Si metal-oxide-semiconductor field-effect transistors. PMID- 9942601 TI - Raman study of the effects of annealing on folded LA and confined LO phonons in GaAs-AlAs superlattices. PMID- 9942602 TI - Solid-phase epitaxy of amorphous silicon induced by electron irradiation at room temperature. PMID- 9942603 TI - Atomic oxygen in silicon: The formation of the Si-O-Si bond. PMID- 9942604 TI - Process-induced and gold acceptor defects in silicon. PMID- 9942606 TI - Adatom electronic structure of the Si(111)7 x 7 surface. PMID- 9942605 TI - Exciton binding energies from an envelope-function analysis of data on narrow quantum wells of integral monolayer widths in Al0.4Ga PMID- 9942607 TI - Bulk and surface electronic bands of InP(110) determined by angle-resolved photoemission. PMID- 9942608 TI - Theory of the carrier-carrier and carrier-phonon interactions under double injection into undoped quantum wells and its application to a laser problem. PMID- 9942610 TI - Effect of valence-band hybridization on the exciton spectra in GaAs-Ga1-xAlxAs quantum wells. PMID- 9942609 TI - Hot-electron transport in silver halides in crossed electric and magnetic fields at 4.2 K. PMID- 9942611 TI - Coordination-number-induced morphological structural transition in a network glass. PMID- 9942612 TI - Energy transfer between europium and manganese close pairs in monocrystalline sodium bromide. PMID- 9942613 TI - X-ray-absorption spectroscopy studies of glassy As2S PMID- 9942614 TI - Skeleton-side-group interaction in organopolysilane. PMID- 9942615 TI - Properties of FeCl3-intercalated graphite film prepared by heat treatment of poly(p-phenylene vinylene) film. PMID- 9942617 TI - Helicon-wave damping in a periodic structure. PMID- 9942616 TI - Electrical conductivity and optical reflectance of potassium-intercalated graphitized poly(p-phenylene vinylene) films. PMID- 9942618 TI - Dynamical effects on phonon emission in a polar electron gas. PMID- 9942619 TI - Band structure and interband optical transitions in the sawtooth superlattice. PMID- 9942620 TI - Equivalence of Lei and Ting balance equations for nonlinear electronic transport and a Boltzmann approach. PMID- 9942621 TI - Balance-equation approach to high-field electronic transport: A linear-response theory in the scattering interactions. PMID- 9942622 TI - Large valence-band offset in strained-layer InxGa PMID- 9942623 TI - Coupling of vibrational modes of adsorbates: Application to field-induced shifts for CO and CN on Cu(100). PMID- 9942624 TI - Resistance of a one-atom contact in the scanning tunneling microscope. PMID- 9942625 TI - Cyclotron resonance in AlxGa PMID- 9942626 TI - Transient behavior of scattering, hot luminescence, and ordinary luminescence in a localized-electron-phonon system. PMID- 9942628 TI - Collective modes of a quasi-two-dimensional electron gas in a cylindrical quantum well. PMID- 9942627 TI - Far-infrared magnetoabsorption study of weakly bound electrons in GaAs/AlxGa PMID- 9942630 TI - NMR study of Fe hyperfine field assignments in Nd15Fe PMID- 9942629 TI - Quantum electron glass. PMID- 9942631 TI - Noble-gas bubbles in metals: Molecular-dynamics simulations and positron states. PMID- 9942632 TI - 4f multiplets in bremsstrahlung-isochromat spectroscopy as a probe for local electron density in Ce compounds. PMID- 9942633 TI - Synthesis of metastable phases via pulsed-laser-induced reactive quenching at liquid-solid interfaces. PMID- 9942634 TI - Excited-state photoionization of Ce3+ ions in Ce3+:CaF2. PMID- 9942635 TI - Influence of rare gases on cavity formation at indium impurities in copper. PMID- 9942636 TI - Temperature-dependent rare-earth impurity-site symmetries in CaF2. PMID- 9942638 TI - 23Na quadrupolar relaxation study of disorder effects in KTaO3:Na. PMID- 9942637 TI - Dynamical properties of LiI PMID- 9942639 TI - Electronic correlations in YBa2Cu PMID- 9942641 TI - Adsorption and desorption studies of 4He on Nuclepore by capacitance techniques. PMID- 9942642 TI - Antiferromagnetic order and high-temperature superconductivity. PMID- 9942640 TI - Structure of YBa2Cu3O7- delta versus temperature by x-ray-absorption spectroscopy. PMID- 9942643 TI - Microwave observation of magnetic field penetration of high-Tc superconducting oxides. PMID- 9942644 TI - Phonon characterization of YBa2(Cu1-xAlx)3O7- delta by Raman spectroscopy. PMID- 9942645 TI - Raman scattering in MBa PMID- 9942646 TI - Raman spectroscopy and normal-mode assignments for Ba2MCu3Ox (M = Gd,Y) single crystals. PMID- 9942647 TI - High-magnetic-field study of superconducting YBa2Cu PMID- 9942648 TI - Chaotic behavior in an array of coupled Josephson weak links. PMID- 9942650 TI - Path-integral computation of superfluid densities. PMID- 9942651 TI - Upper critical field of superconducting anisotropic polycrystals. PMID- 9942649 TI - Superconducting-normal phase boundary of quasicrystalline arrays in a magnetic field. PMID- 9942653 TI - Aluminum substitution in Ba2YCu3O7. PMID- 9942652 TI - Functional derivatives of Hc2 including Pauli paramagnetism. PMID- 9942654 TI - Surface properties of liquid 3He PMID- 9942656 TI - 3d-metal doping of the high-temperature superconducting perovskites La-Sr-Cu-O and Y-Ba-Cu-O. PMID- 9942655 TI - Dynamics of quantum liquids at high momentum. PMID- 9942657 TI - Extended x-ray-absorption fine-structure study of La2-xSrxCuO4-y superconductors. PMID- 9942658 TI - Experimental study of the effect of a supercurrent on high-resistance superconductor-insulator- normal-metal tunnel junctions. PMID- 9942660 TI - Noise simulations of an Ising model of glassy kinetics. PMID- 9942659 TI - Anderson Hamiltonian description of the experimental electronic structure and magnetic interactions of copper oxide superconductors. PMID- 9942661 TI - Growth and equilibration in the two-dimensional random-field Ising model. PMID- 9942662 TI - Melting and freezing of Lennard-Jones clusters on a surface. PMID- 9942663 TI - Percolation of order in frustrated systems: The dilute PMID- 9942664 TI - Magnetic susceptibilities of the random-site diluted XY antiferromagnet PMID- 9942665 TI - Spin correlations in Au0.85Fe PMID- 9942667 TI - Site-bond-correlated D-vector model on the Bethe lattice. PMID- 9942666 TI - Free energy and the relative stability of the phases of solid tetracyanoethylene with pressure and temperature. PMID- 9942668 TI - Mean-field theory of the proton glass. PMID- 9942670 TI - Lattice sums for dipolar systems. PMID- 9942669 TI - Long-wavelength spin-wave energies and linewidths of the amorphous Invar alloy Fe100-xBx. PMID- 9942671 TI - Random-strain fields in (KCl)1-x (KCN)x. PMID- 9942672 TI - Neutron scattering measurements of spin fluctuations in the heavy-fermion system UPt3. PMID- 9942673 TI - Comparative studies of electronic and magnetic structures in Y2Fe PMID- 9942674 TI - Pressure-induced structural transitions and valence change in TlReO4: A high pressure Raman study. PMID- 9942675 TI - Stable and metastable states in mean-field Potts and structural glasses. PMID- 9942677 TI - Magnetic properties of UBr3. PMID- 9942676 TI - Metamagnetic behavior of fcc iron. PMID- 9942678 TI - Ferromagnetic resonance in magnetic multilayer structures. PMID- 9942679 TI - Conformal anomaly and critical exponents of Heisenberg spin models with half integer spin. PMID- 9942680 TI - Magneto-optical properties of the competing-anisotropy model system Fe1-xCoxCl2. I. Linear birefringence and refractive index. PMID- 9942681 TI - Renormalization-group study of high-spin Heisenberg antiferromagnets. PMID- 9942682 TI - Random-field smearing of the proton-glass transition. PMID- 9942684 TI - Magnetism in Au82.5Fe17.5. PMID- 9942683 TI - Rare-earth contribution to the magnetocrystalline anisotropy energy in R2Fe14B. PMID- 9942685 TI - Gross magnetic resonance in small ferromagnetic particles. PMID- 9942686 TI - Hybrid molecular-dynamics algorithm for the numerical simulation of many-electron systems. PMID- 9942687 TI - Competing bilinear and biquadratic exchange couplings in spin-1 Heisenberg chains. PMID- 9942689 TI - Distribution of fracture strengths in disordered continua. PMID- 9942688 TI - Localization in quantum percolation: Transfer-matrix calculations in three dimensions. PMID- 9942690 TI - Low-temperature properties of rare-earth and actinide iron phosphide compounds MFe4P12 (M = La, Pr, Nd, and Th). PMID- 9942691 TI - Pressure-dependent magnetism and electrical resistivity of UFe4P PMID- 9942693 TI - Phonon anomalies and the magnetic transition in pure and Cr-doped V2O PMID- 9942692 TI - Observations of magnetic and structural ordering in TbH2+x compounds through electrical resistivity measurements. PMID- 9942694 TI - Linked-cluster series-expansion technique for quantum spin systems. PMID- 9942696 TI - Magnetic properties of alternate nonclassical polymers: The elementary excitation spectrum. PMID- 9942695 TI - Application of spin-wave theory to the ground state of XY quantum Hamiltonians. PMID- 9942697 TI - New type of two-dimensional phase transition. PMID- 9942698 TI - Wetting on cylinders and spheres. PMID- 9942699 TI - Variational ground state for the periodic Anderson model with an indirect hybridization. PMID- 9942700 TI - Diffusion on percolating clusters. PMID- 9942701 TI - Polarized neutron-diffraction study of spin-density distribution in chromium tribromide. PMID- 9942702 TI - Sensitivity of third sound to the 3He effective mass in 3He PMID- 9942703 TI - Theoretical explanation of zero-field splitting and its pressure, stress, and temperature dependence in NiSiF6 PMID- 9942704 TI - Bragg reflection of low-energy positrons from the surface of graphite. PMID- 9942705 TI - Specific heat of La1.8Sr0.2CuO4: Anomaly at the superconducting transition. PMID- 9942706 TI - Model-independent tests of excitonic enhancement in high-Tc superconductors. PMID- 9942708 TI - Processes yielding high superconducting temperatures. PMID- 9942707 TI - Low-temperature thermal conductivity of YBa2Cu3O7- delta. PMID- 9942709 TI - Magnetic ordering and magnetization in the high-temperature superconductor ErBa2Cu PMID- 9942710 TI - Excitations of a diamagnetic hole state in the copper-oxide superconductors. PMID- 9942711 TI - Superconducting HxYBa PMID- 9942712 TI - Superconducting energy gap of YBa2Cu3O9- delta measured by far-infrared reflection. PMID- 9942713 TI - Magnetic characterization of rare-earth barium cuprate superconductors. PMID- 9942714 TI - Structural behavior of the La2CuO4-based superconducting compounds. PMID- 9942715 TI - Structure of the high-Tc superconductor Ba2YCu3O7+x above (124 K) and below (71 K) Tc by neutron diffraction. PMID- 9942717 TI - Superconducting and nonsuperconducting phases of YBa2Cu PMID- 9942716 TI - Anomalous thermal conductivity of La2-xSrxCuO4: Possibility of a polaronic glass. PMID- 9942718 TI - Influence of Fe impurities on the Y-Ba-Cu-O superconducting system. PMID- 9942719 TI - Superconductivity and random disorder in the infinite-range hopping model. PMID- 9942720 TI - Hc2 spectroscopy of geometrical effects in La-S films. PMID- 9942721 TI - Condition for spin-rotational invariance in a semi-infinite itinerant-electron ferromagnet. PMID- 9942723 TI - Magnetic form factor and spin-density asphericity of Ni-Cu. PMID- 9942722 TI - Ruderman-Kittel-Kasuya-Yosida indirect interaction in two dimensions. PMID- 9942724 TI - Transport properties of the heavy-fermion compound CeCu6 down to 14 mK. PMID- 9942725 TI - Fast ionic conduction via site percolation in AgI-AgPO3 glasses. PMID- 9942726 TI - Effective medium versus critical behavior of the failure threshold in percolation. PMID- 9942728 TI - Temperature dependence of positron-annihilation parameters in YBa2Cu3O7-x above and below the superconducting transition. PMID- 9942727 TI - Generation of slow positive muons from solid rare-gas moderators. PMID- 9942729 TI - Electron paramagnetic resonance absorption in high-Tc superconducting GdBa2Cu3Ox. PMID- 9942731 TI - Cluster studies of the electronic structure of Cu-O chains in high-temperature superconductors. PMID- 9942730 TI - Hole formation in orthorhombic and tetragonal YBa2Cu PMID- 9942733 TI - Multiple-gap tunneling structure observed for the high-Tc superconductors: Charging effects as possible cause. PMID- 9942732 TI - Comparison of the electrodynamic properties of sintered YBa2Cu3O7-y and La1.85Sr0.15CuO4-y. PMID- 9942734 TI - Metal-insulator transition and superconductivity in Y1Ba2Cu3O7-x. PMID- 9942736 TI - Thermopower of YBa2Cu PMID- 9942735 TI - Stabilization of the tetragonal phase and superconducting behavior in RBa2(Cu1 xFex)3Oy (R=Y,Gd; 0 <= x <= 0.15). PMID- 9942737 TI - Infrared anisotropy of La1.85Sr PMID- 9942738 TI - Precautions when interpreting EPR and dc magnetization measurements of high-Tc RBa2Cu3Oy-phase superconducting materials. PMID- 9942739 TI - Correlation between superconductivity and optical excitations. PMID- 9942740 TI - Twin-boundary dynamics and properties of high-Tc superconductors. PMID- 9942741 TI - Probing electronic density of states and magnetic interactions at the rare-earth site in ErBa2Cu3O7. PMID- 9942742 TI - Properties of epitaxial films of YBa2Cu3O7- delta. PMID- 9942743 TI - Anelastic relaxation in the high-Tc superconductor YBa2Cu PMID- 9942744 TI - Magnetic isolation of Gd in superconducting GdBa2Cu3O7- delta. PMID- 9942745 TI - Magnetic microstructure and flux dynamics of high-Tc superconductors. PMID- 9942746 TI - Local distortions and reduction in Tc in the ceramic superconductor La1.8Sr0.2Cu1 xAgxO4. PMID- 9942747 TI - 3He melting curve below 15 mK. PMID- 9942748 TI - Multifractals and critical phenomena in percolating networks: Fixed point, gap scaling, and universality. PMID- 9942750 TI - Absence of the hump in the density of states of percolating clusters. PMID- 9942749 TI - Evolution of magnetism from mixed-valent CeIr3B2 to trivalent CeIr3Si2. PMID- 9942751 TI - Static and dynamic behavior of spin-glass films. PMID- 9942752 TI - Thermally induced two-level systems in glasses and nuclear spin-lattice relaxation. PMID- 9942753 TI - Phase diagrams of the spin-1 Ising Blume-Emery-Griffiths model: Monte Carlo simulations. PMID- 9942754 TI - Hyperbolic grain boundaries. PMID- 9942755 TI - Neutron observation of phase and amplitude modes in an n=4 incommensurate system. PMID- 9942756 TI - Mn local structure in the decagonal phase of Al-Mn alloys. PMID- 9942757 TI - Nernst-Ettingshausen coefficient measurements on Al below 1 K. PMID- 9942758 TI - Long-range excitation of electron-hole pairs in atom-surface scattering. PMID- 9942759 TI - Formation and structure of Fe/Cu(001) interfaces, sandwiches, and superlattices. PMID- 9942761 TI - Angular momentum branching ratios for electron-induced ionization: Atomic and model calculations. PMID- 9942760 TI - End-point energies of electrons ejected during Auger neutralization of slow, multicharged ions near metal surfaces. PMID- 9942762 TI - Charge transfer and coherent charge propagation in metal-insulator junctions. PMID- 9942763 TI - Effect of a magnetic field on weak localization and Coulomb interactions in acceptor graphite intercalation compounds. PMID- 9942764 TI - Temperature and impurity dependence of the electrical resistivity in dilute gallium-based alloys. II. a-axis crystals. PMID- 9942765 TI - Polaron in n dimensions. PMID- 9942766 TI - Effects of adsorption on equilibrium crystal shape: A zero-temperature calculation. PMID- 9942768 TI - Calculation of conduction-electron scattering rates from vacancies in copper and gold. PMID- 9942767 TI - Conduction-electron scattering from vacancies in copper. PMID- 9942769 TI - Phonons in broken-symmetry structures. PMID- 9942770 TI - Local lattice expansion around Pd impurities in Cu and its influence on the Pd density of states: An extended x-ray-absorption fine-structure and Auger study. PMID- 9942771 TI - Si(111)7 x 7 and Si(111) sqrt 3-bar x sqrt 3-bar-al surface-structure analysis by ion-induced Auger-electron spectroscopy. PMID- 9942772 TI - Electronic properties and superconductivity of rapidly quenched Al-Si alloys. PMID- 9942774 TI - Resonant Raman scattering in GaP: Excitonic and interference effects near the E0 and E0+ Delta 0 gaps. PMID- 9942773 TI - Equilibrium sites and electronic structure of interstitial hydrogen in Si. PMID- 9942775 TI - Nonlinear electronic transport in semiconductor systems with two types of carriers: Application to GaAs. PMID- 9942777 TI - Magnetophonon effect in Hg1-xCdxTe. PMID- 9942776 TI - Continuum-model acoustic and electronic properties for a Fibonacci superlattice. PMID- 9942779 TI - Cyclotron-resonance linewidth oscillations in the integer and fractional quantum Hall regimes. PMID- 9942778 TI - Impact-collision ion-scattering-spectrometry study of Ni layers deposited on Si(111) at room temperature. PMID- 9942780 TI - Measurement of local structural configurations associated with reversible photostructural changes in arsenic trisulfide films. PMID- 9942781 TI - Hydrogenation of low-pressure chemical-vapor-deposition silicon thin films. PMID- 9942782 TI - Electronic transport across a grain boundary in semiconductors. PMID- 9942783 TI - Atomistic simulation of defects in alkaline-earth fluorohalide crystals. PMID- 9942784 TI - In situ optical-reflectance study of H2 physisorption in C24K. PMID- 9942785 TI - Optical studies of methane under high pressure. PMID- 9942786 TI - Hyperpolarizabilities of alkali halide crystals using the local-density approximation. PMID- 9942787 TI - Neutron-scattering studies of phonons in disordered cubic zirconia at elevated temperatures. PMID- 9942788 TI - Structure and dynamics of amorphous water ice. AB - Further insight into the structure and dynamics of amorphous water ice, at low temperatures, was obtained by trapping in it Ar, Ne, H2, and D2. Ballistic water vapor deposition results in the growth of smooth, approximately 1 x 0.2 micrometer2, ice needles. The amorphous ice seems to exist in at least two separate forms, at T < 85 K and at 85 < T < 136.8 K, and transform irreversibly from one form to the other through a series of temperature-dependent metastable states. The channels formed by the water hexagons in the ice are wide enough to allow the free penetration of H2 and D2 into the ice matrix even in the relatively compact cubic ice, resulting in H2-(D2-) to-ice ratios (by number) as high as 0.63. The larger Ar atoms can penetrate only into the wider channels of amorphous ice, and Ne is an intermediate case. Dynamic percolation behavior explains the emergence of Ar and Ne (but not H2 and D2) for the ice, upon warming, in small and big gas jets. The big jets, each containing approximately 5 x 10(10) atoms, break and propel the ice needles. Dynamic percolation also explains the collapse of the ice matrix under bombardment by Ar , at a pressure exceeding 2.6 dyn cm-2, and the burial of huge amounts of gas inside the collapsed matrix, up to an Ar-to-ice of 3.3 (by number). The experimental results could be relevant to comets, icy satellites, and icy grain mantles in dense interstellar clouds. PMID- 9942789 TI - Effect of hybridization on 4d-->4f spectra in light lanthanides. PMID- 9942790 TI - Anisotropy of BN and Be x-ray-emission bands. PMID- 9942791 TI - Oxygen K x-ray-absorption near-edge structure of alkaline-earth-metal and 3d transition-metal oxides. PMID- 9942792 TI - Laser-induced anti-Stokes resonance Raman scattering: Probe for energy transfer in F-center-CN--molecule defect pairs in CsCl. PMID- 9942793 TI - Vibrational mode frequencies, phase diagram, and optical transmission of solid hydrogen iodide to 25 GPa. PMID- 9942794 TI - Electronic and magnetic properties of manganese impurities in aluminum. PMID- 9942796 TI - Tight-binding electrons on open chains: Density distribution and correlations. PMID- 9942795 TI - Structure and mechanism of alkali-metal-induced reconstruction of fcc (110) surfaces. PMID- 9942797 TI - Acoustic plasmons in Hg3- delta AsF6 in the long-wavelength limit. PMID- 9942798 TI - Concentration dependence of Raman scattering in superionic glasses (AgI)x(Ag2OH2O3)1-x. PMID- 9942799 TI - Spin-orbit coupling effects in CdGa2Se4:Co2+ single crystals. PMID- 9942800 TI - Raman scattering in a GaAs/Ga1-xAlxAs Fibonacci superlattice. PMID- 9942801 TI - Effective mass in an n-type HgTe-CdTe superlattice. PMID- 9942802 TI - Excitonic optical nonlinearity and exciton dynamics in semiconductor quantum dots. PMID- 9942803 TI - Direct evidence for screening of the Coulomb interaction in quasi-two-dimensional systems. PMID- 9942804 TI - Semiempirical equation of state of solid hydrogen iodide. PMID- 9942805 TI - Disclinations in pentagonal quasicrystals. PMID- 9942807 TI - Influence of surface step density on reflection high-energy-electron diffraction specular intensity during epitaxial growth. PMID- 9942806 TI - Heterogenous mixed-valence and compound formation in ordered Yb/Ni(100) overlayers. PMID- 9942808 TI - Neutron spectroscopic evidence for subsurface hydrogen in palladium. PMID- 9942809 TI - All-electron local-density theory of the rippled NiAl(110) surface. PMID- 9942810 TI - Backscattering of light near the optical Anderson transition. PMID- 9942811 TI - Aharonov-Bohm effect in the hopping conductivity of a small ring. PMID- 9942813 TI - Electronic inelastic lifetime near a mobility edge. PMID- 9942812 TI - Inelastic electron scattering of surface and bulk phonons on Cu(001)-p(2 x 2)S. PMID- 9942815 TI - Effect of charge-density waves on the x-ray emission edges of simple metals. PMID- 9942814 TI - Spin-orbit-interaction-induced surface resonance on W(011). PMID- 9942816 TI - Phonon anomaly in K1-xRbxC8. PMID- 9942817 TI - Thermal-equilibrium processes in undoped amorphous-silicon alloys. PMID- 9942818 TI - Weakly bound deuterium in a-Si:D,H. PMID- 9942819 TI - Unexplored properties of defects with triply degenerate gap states in semiconductors: The role of lattice distortion. PMID- 9942821 TI - Empirical laws and their theoretical justification for the crystal-field splitting and ionization energy of transition-metal ions in semiconductors. PMID- 9942820 TI - Spin-flip Raman scattering from Cd1-xMnxTe:In epilayers and modulation-doped Cd1 xMnxTe:In/CdTe superlattices grown by photoassisted molecular-beam epitaxy. PMID- 9942822 TI - Critical currents of the quantum Hall effect in the mesoscopic regime. PMID- 9942823 TI - Conduction-band offset determination in GaAs-AlxGa1-xAs through measurement of infrared internal photoemission. PMID- 9942824 TI - Critical criterion for axial models of defects in as-grown n-type GaAs. PMID- 9942825 TI - Light-induced perturbation of the high-temperature equilibrium in phosphorus doped a-Si:H. PMID- 9942826 TI - Observation of the transition associated with real-space transfer of a two dimensional electron gas to a three-dimensional electron distribution in semiconductor heterolayers. PMID- 9942827 TI - Conclusive evidence for miniband dispersion in the photoreflectance of a GaAs/Ga0.74Al PMID- 9942828 TI - Common-anion rule and its limits: Photoemission studies of CuInxGa1-xSe2-Ge and CuxAg1-xInSe2-Ge interfaces. PMID- 9942829 TI - Deep-level defects in silicon and the band-edge hydrostatic deformation potentials. PMID- 9942830 TI - Coherent Raman spectroscopy of spin transitions in semimagnetic Pb1-xMnxTe. PMID- 9942831 TI - Some novel effects of space charge and crossed electric fields on energy levels and low-temperature diamagnetism in two-dimensional electron systems. PMID- 9942832 TI - Electron-transport dynamics in quantized intrinsic GaAs. PMID- 9942833 TI - Relaxation and surface states on wurtzite cleavage faces: CdSe(101-bar0). PMID- 9942835 TI - Rapid intensity fluctuations of light scattered by glasses. PMID- 9942834 TI - Novel approach for structure analysis by x-ray Raman scattering. PMID- 9942836 TI - Role of lattice matching in epitaxy: Novel Ce phase and new fcc-bcc epitaxial relationship. PMID- 9942837 TI - Electronic states, bonding, and x-ray absorption spectra of Pd2Si. PMID- 9942838 TI - Cadmium-ion distribution and motion in beta -alumina: An x-ray-diffraction and Raman-scattering investigation. PMID- 9942839 TI - Jump rate of the fcc vacancy in the short-memory-augmented-rate-theory approximation. I. Difference Monte Carlo sampling for the Vineyard rate. PMID- 9942840 TI - Jump rate of the fcc vacancy in the short-memory-augmented-rate-theory approximation. II. Dynamical conversion coefficient and isotope-effect factor. PMID- 9942841 TI - Transport properties of Rb in high magnetic fields. PMID- 9942842 TI - Resonance photoemission for f-electron systems. PMID- 9942843 TI - Image-potential states on clean and hydrogen-covered Pd surfaces: Analysis of a one-dimensional model. PMID- 9942844 TI - Theory of acoustical activity. PMID- 9942845 TI - Angle-resolved photoemission study of the valence-band structure of VN0.89(100). PMID- 9942846 TI - Theoretical paramagnetic form factors for hcp transition metals. PMID- 9942847 TI - Effect of a spinodal decomposition on a resistivity anomaly in a binary alloy. PMID- 9942848 TI - Production and thermal annealing of neutrino-recoil-induced Frenkel pairs in copper. PMID- 9942849 TI - Diffusion and thermal stability of amorphous copper zirconium. PMID- 9942852 TI - Interface formation of GaAs with Si(100), Si(111), and Ge(111): Core-level spectroscopy for monolayer coverages of GaAs, Ga, and As. PMID- 9942851 TI - Fundamental optical properties of heavily-boron-doped silicon. PMID- 9942850 TI - Auger shifts in metal clusters. PMID- 9942853 TI - Effect of a finite-width barrier on binding energy in modulation-doped quantum well structures. PMID- 9942854 TI - Influence of the electric field on the fractional quantum Hall effect. PMID- 9942855 TI - Direct and indirect electron-hole plasmas in gallium selenide. PMID- 9942856 TI - Phonon renormalization effects in quantum wells. PMID- 9942857 TI - Electron trapping in quantum-well structures. PMID- 9942859 TI - Evaluation of semiempirical quantum-chemical methods in solid-state applications. II. Cyclic-cluster calculations of silicon. PMID- 9942858 TI - Evaluation of semiempirical quantum-chemical methods in solid-state applications. I. Molecular-cluster calculations of defects in silicon. PMID- 9942860 TI - Bipolaron lattices on multiply excited polymer chains of finite length. PMID- 9942861 TI - Theory of the Pb center at the <111> Si/SiO2 interface. PMID- 9942862 TI - Quantum transport in the coupled electron-acoustic-phonon system: Application to energy transport in Si and Ge. PMID- 9942863 TI - Electronic structure of the quaternary alloy GaxIn1-xAsyP1-y: A coherent potential-approximation calculation. PMID- 9942864 TI - Low-temperature infrared absorption of n-type GaP. PMID- 9942866 TI - Theory of optical transitions in Si/Ge(001) strained-layer superlattices. PMID- 9942865 TI - Quantum thermal noise of electrons in semiconductors under crossed magnetic and electric fields. PMID- 9942867 TI - Bonds in III-V quaternary alloy semiconductors of AIII1-xBIIIxCV1-yDVy type. PMID- 9942869 TI - Empirical tight-binding calculation of dispersion in the second-order nonlinear optical constant for zinc-blende crystals. PMID- 9942868 TI - Adsorption-induced enhanced photoconductivity: A reevaluation. PMID- 9942871 TI - Electron-energy-loss spectra of GaSe and Ga metal. PMID- 9942870 TI - Structure and properties of amorphous hydrogenated silicon carbide. PMID- 9942873 TI - Chemical and medium-range orders in As2S PMID- 9942872 TI - Quasielastic electron scattering as a probe of the silicon surface space-charge region. PMID- 9942874 TI - Optical transmission spectrum of incommensurate crystals: Application to Rb2ZnBr PMID- 9942875 TI - Effect of dynamical screening on the polaron cyclotron-resonance mass of a two dimensional electron gas in GaAs-AlxGa PMID- 9942876 TI - Temperature dependence of the polaron mass in a GaAs-AlxGa1-xAs heterostructure. PMID- 9942878 TI - Stopping of Havar, nickel, Kapton, and Mylar for 5-19-MeV 16O ions. PMID- 9942877 TI - Dipole-relaxation parameters for Ce3+-Fint PMID- 9942879 TI - Site-selective laser spectroscopy of CaF2:Pr3+ and CaF2:Pr3+,R3+ (R3+=Y PMID- 9942880 TI - High-pressure x-ray diffraction studies on rhenium up to 216 GPa (2.16 Mbar). PMID- 9942881 TI - Possibility of electron-neutron emission spectroscopy. PMID- 9942883 TI - Angle-resolved photoelectron-spectroscopy study of the Si(001)2 x 1-K surface. PMID- 9942882 TI - Vibrational spectroscopy of H on Pt(111): Evidence for universally soft parallel modes. PMID- 9942884 TI - Reaction mechanism for fluorine etching of silicon. PMID- 9942886 TI - Phase-resolved photoacoustic spectroscopy: Application to metallic-ion-doped glasses. PMID- 9942887 TI - Interface polaron in magnetic fields of arbitrary strength. PMID- 9942885 TI - Structural studies of Ga-adsorbed Si(111) sqrt 3-bar x sqrt 3-bar surfaces by low energy electron diffraction. PMID- 9942888 TI - Simple classical calculation of thermal expansion for rare-gas solids. PMID- 9942889 TI - Interactions of ethanol with clean and oxygen-preadsorbed surfaces of polycrystalline Ag studied by photoacoustic spectroscopy. PMID- 9942890 TI - Absence of two-electron resonances in valence-band photoemission from Cr, Mn, Fe, and Co. PMID- 9942892 TI - Spatial distribution of tunnel current and application to scanning-tunneling microscopy: A semiclassical treatment. PMID- 9942891 TI - Correlation correction to the Hartree-Fock total energy of solids. PMID- 9942894 TI - Interpretation of face-specific effects for atom adsorption on metal surfaces. PMID- 9942893 TI - Spin-polarized bands via the recursion method: FeNi3 as a test case. PMID- 9942895 TI - Angular and polarization dependence of surface-enhanced Raman scattering in attenuated-total-reflection geometry. PMID- 9942896 TI - Angle-resolved photoemission study of the Ni(110)(12)-H reconstructed surface at 80 K. PMID- 9942897 TI - Self-energy corrections to the ab initio band structure: Chromium. PMID- 9942898 TI - Angle-resolved photoemission study of the (100) surface of substoichiometric TiN: A vacancy-induced state. PMID- 9942900 TI - Evolution of the electronic and structural properties of microclusters. PMID- 9942899 TI - Gap solitons in nonlinear periodic structures. PMID- 9942902 TI - Electron-phonon interaction and phonon dynamics in one-dimensional conductors: Spinless fermions. PMID- 9942901 TI - Surface topography in scanning tunneling microscopy: A free-electron model. PMID- 9942903 TI - Determination of bond strengths of arsenic and arsenic chalcogen compounds using the temperature dependence of extended x-ray-absorption fine structure. PMID- 9942904 TI - Photoemission study of the valence band of Pb monolayers on Ge(111). PMID- 9942905 TI - Electronic structure and plasma excitations at the surface of small voids in jellium. PMID- 9942906 TI - Electromagnetic modes of corrugated thin films and surfaces with a transition layer: Basic formalism. PMID- 9942908 TI - Time-dependent theory of hot electrons using the discrete Boltzmann equation. PMID- 9942907 TI - Interface vibrational Raman lines in GaAs/AlxGa1-xAs superlattices. PMID- 9942909 TI - Bonding and ionicity in semiconductors. PMID- 9942910 TI - Surface plasmons on n-type semiconductors: Influence of depletion and accumulation layers. PMID- 9942911 TI - Atomistic simulation of silicon beam deposition. PMID- 9942912 TI - Chemical bonding in ordered Ce overlayers on Si(111). PMID- 9942913 TI - Dynamical conductivity in the infrared from impurity scattering in a polar semiconductor. PMID- 9942915 TI - Negative-U defect: Interstitial boron in silicon. PMID- 9942914 TI - Localization behavior of donor-related complexes in InP under hydrostatic pressure. PMID- 9942916 TI - Theoretical approach to heterojunction valence-band discontinuities: Case of a common anion. PMID- 9942917 TI - Molecular coherent-potential approximation for zinc-blende pseudobinary alloys. PMID- 9942918 TI - Band structure and electronic properties of native defects in cubic SiC. PMID- 9942919 TI - Cooling of an electron-hole plasma in a Ga0.47In0.53As multiple-quantum-well structure. PMID- 9942920 TI - Photoluminescence due to exciton-exciton scattering in GaSe under picosecond laser excitations. PMID- 9942921 TI - Influence of hydrogen on vibrational and optical properties of a-Si1-xHx alloys. PMID- 9942922 TI - Application of the linear-analytic tetrahedra method of zone integration to nonlinear response functions. PMID- 9942923 TI - Soft-x-ray emission spectroscopy study of the electronic structure of nonstoichiometric silicon nitride. PMID- 9942924 TI - Urbach rule in mixed single crystals of ZnxCd PMID- 9942925 TI - Temperature shift of the absorption edge in mixed single crystals of ZnxCd1-xSe. PMID- 9942926 TI - Hole-phonon relaxation time and Landau-level broadening due to hole-phonon interactions in multiple-quantum-well structures in the presence of a magnetic field and internal strains. PMID- 9942927 TI - Bent-band theory of conductivity in heavily doped semiconductors at low temperatures. PMID- 9942928 TI - Photoluminescence of CdSe: Evidence for selective etching of donor states. PMID- 9942929 TI - Structure and bonding of small semiconductor clusters. PMID- 9942930 TI - Theory of surface magnetoplasmon polaritons in truncated superlattices. PMID- 9942931 TI - Self-consistent study of confined states in thin GaAs-AlAs superlattices. PMID- 9942932 TI - Soft-mode spectroscopy and pyroelectricity in KTaO3:Na. PMID- 9942933 TI - Covalent insulator CeO2: Optical reflectivity measurements. PMID- 9942934 TI - Optical detection of metastable H2- defects and photoconversion of anion vacancies in thermochemically reduced CaO crystals. PMID- 9942935 TI - Low-energy electron diffraction study of molecular oxygen physisorbed on graphite. PMID- 9942936 TI - Channeling radiation from GaAs. PMID- 9942937 TI - Analysis of giant quantum attenuation of sound waves due to spin-split Landau levels in bismuth. PMID- 9942939 TI - Symmetry of the EL2 defect in GaAs. PMID- 9942938 TI - Microwave photoresistivity of a two-dimensional electron gas and the fractional quantum Hall effect. PMID- 9942941 TI - Erratum: Screening of the intermolecular van der Waals interaction at a metal surface PMID- 9942942 TI - Unoccupied electron band structure of Na overlayers on Al(111). PMID- 9942940 TI - Comment on "Solvated polaron in an ionic lattice" PMID- 9942944 TI - Transition from the tunneling regime to point contact studied using scanning tunneling microscopy. PMID- 9942943 TI - Spin- and angle-resolved photoemission study of ultrathin Gd films on Fe(100). PMID- 9942945 TI - Identification of underlayer components in the surface core-level spectra of W(111). PMID- 9942946 TI - Photoemission from supported metal clusters: The problem of the support. PMID- 9942947 TI - Electronic properties of the iron-boron impurity pair in silicon. PMID- 9942948 TI - Stark effect in GaAs-AlxGa PMID- 9942949 TI - Measurement of the weak-field conduction-electron g value in In0.53Ga PMID- 9942950 TI - Experimental evidence for coupled-mode phonon gaps in superlattice structures. PMID- 9942952 TI - Coherence of resonant tunneling in heterostructures. PMID- 9942951 TI - Indirect, quasidirect, and direct optical transitions in the pseudomorphic (44) monolayer Si-Ge strained-layer superlattice on Si(001). PMID- 9942953 TI - Picosecond Raman scattering from photoexcited plasmas in GaAs and InP: The important role of interfacial recombination. PMID- 9942954 TI - Electronic energy levels in InxGa PMID- 9942955 TI - Determination of the PIn antisite structure in InP by optically detected electron nuclear double resonance. PMID- 9942956 TI - Sb/GaAs(110) interface: A reevaluation. PMID- 9942957 TI - Arsenic antisite defect AsGa and EL2 in GaAs. PMID- 9942958 TI - Role of dangling bonds at Schottky barriers and semiconductor heterojunctions. PMID- 9942959 TI - Epitaxial growth of silicon: A molecular-dynamics simulation. PMID- 9942960 TI - Hydrogen-implantation-induced damage in silicon. PMID- 9942961 TI - Realization of the Esaki-Tsu-type doping superlattice. PMID- 9942962 TI - Velocity-field characteristics with two maxima in compensated GaAs. PMID- 9942963 TI - Molecular-dynamics simulation of the growth of strained-layer lattices. PMID- 9942964 TI - Electronic excitations of pure and doped rare-gas fluids: Theory and experiment. PMID- 9942965 TI - Extended x-ray-absorption fine structure of liquid water. PMID- 9942966 TI - High-resolution photoemission study of the interfacial reaction of Cr with polyimide and model polymers. PMID- 9942968 TI - T operators and their matrix elements for a general periodic potential. PMID- 9942967 TI - Energy-band equation for a general periodic potential. PMID- 9942970 TI - Nd1+ epsilon Fe4B4: A composition-modulated compound with incommensurate composite crystal structure. PMID- 9942969 TI - Friedel-type sum rule for a general periodic potential. PMID- 9942971 TI - Electron densities in VN. I. High-precision x-ray-diffraction determination of the valence-electron density distribution and atomic displacement parameters. PMID- 9942972 TI - Electron densities in VN. II. Theory. PMID- 9942973 TI - Effect of liquids on the Drude dielectric function of Ag and Au films. PMID- 9942974 TI - Phonon focusing in piezoelectric crystals. PMID- 9942975 TI - Effects of first-order spatial dispersion on phonon focusing: Application to quartz. PMID- 9942976 TI - Magnetic susceptibility of low-dimensional organic conductors with bis(ethylenedithio) tetrathiafulvalene: (BEDT-TTF)3(ClO4)2 and (BEDT TTF)2ClO4(C2H3Cl3)0.5. PMID- 9942978 TI - Molecular lifetimes in the presence of periodically roughened metallic surfaces. PMID- 9942977 TI - Densities of states, projected densities of states, and transfer-matrix methods from a unified point of view. PMID- 9942979 TI - Exact relativistic theory for electron diffraction from planar ideal crystals. PMID- 9942980 TI - Ballistic structure in the electron distribution function of small semiconducting structures: General features and specific trends. PMID- 9942981 TI - Below-band-gap luminescence in doping superlattices. PMID- 9942982 TI - Exciton-polaritons in InP: Magnetoreflectance investigation. PMID- 9942983 TI - Numerical studies of one-electron hydrogenic impurity states in doped semiconductors. II. Fully compensated systems. PMID- 9942984 TI - Long-range order in AlxGa1-xAs. PMID- 9942985 TI - Mixing between heavy-hole and light-hole excitons in GaAs/AlxGa1-xAs quantum wells in an electric field. PMID- 9942986 TI - Amplitude and phase modes in trans-polyacetylene: Resonant Raman scattering and induced infrared activity. PMID- 9942987 TI - New k PMID- 9942988 TI - Determination of single-particle relaxation time from light scattering spectra in modulation-doped quantum wells. PMID- 9942989 TI - Wigner-function model of a resonant-tunneling semiconductor device. PMID- 9942991 TI - Fast-particle energy loss in the vicinity of a two-dimensional plasma. PMID- 9942990 TI - Pressure dependence of direct and indirect optical absorption in GaAs. PMID- 9942993 TI - Chemical trapping and modification of the Au/GaAs(110) interface using Sm interlayers. PMID- 9942992 TI - Laser-induced crystallization of amorphous GeTe: A time-resolved study. PMID- 9942994 TI - Resonance Raman scattering in GaAs-AlxGa1-xAs superlattices: Impurity-induced Frohlich-interaction scattering. PMID- 9942995 TI - Cooperative ring exchange and the fractional quantum Hall effect. PMID- 9942996 TI - Schottky-barrier formation on a covalent semiconductor without Fermi-level pinning: The metal-MoS2(0001) interface. PMID- 9942997 TI - Ellipsometry and structure studies of chromium, molybdenum, and platinum silicides. PMID- 9942999 TI - Breathing-shell alloy model for the phonon dispersion relations of intermediate valence Sm1-xYxS. PMID- 9942998 TI - Atomistic nature of heterointerfaces in III-V semiconductor-based quantum-well structures and its consequences for photoluminescence behavior. PMID- 9943000 TI - Three-center Auger-type nonradiative recombination mechanism in the ZnS lattice. PMID- 9943001 TI - Heating of cold electrons by a warm GaAs lattice: A novel probe of the carrier phonon interaction. PMID- 9943002 TI - Hot-electron noise in two-valley semiconductors: An analytic model. PMID- 9943003 TI - Self-consistent pseudopotential calculation for the electronic structure of a (InAs)1(GaAs)1 monolayer superlattice. PMID- 9943004 TI - Drift mobility of steady-state photocarriers in a-Si:H. PMID- 9943006 TI - Drift mobility of doped a-Si:H at high temperatures. PMID- 9943005 TI - Photoinduced change in the density of localized states near the conduction band of doped a-Si:H. PMID- 9943007 TI - Theory of impurity vibrations due to isolated interstitials and interstitial substitutional pair defects in semiconductors. PMID- 9943008 TI - Density-of-states calculations within the recursion method. PMID- 9943009 TI - Dynamics, photoexcitation, and coherent anharmonicity in polyyne. PMID- 9943010 TI - X-ray absorption studies of CeO2, PrO2, and TbO2. I. Manifestation of localized and extended f states in the 3d absorption spectra. PMID- 9943011 TI - X-ray absorption studies of CeO2, PrO2, and TbO2. II. Rare-earth valence state by LIII absorption edges. PMID- 9943013 TI - Structure of the mixed crystal (KCN)0.7(KBr)0.3 determined by neutron powder diffraction. PMID- 9943012 TI - Elastic scattering from cubic lattice systems with paracrystalline distortion. PMID- 9943014 TI - Specific heat of hemoglobin solutions at temperatures between 1.3 and 10 K. PMID- 9943015 TI - Hohenberg-Kohn kernel K(r-r'). PMID- 9943017 TI - Translational mass of an exciton in a lattice. PMID- 9943016 TI - Effect of plasma waves on the optical properties of conducting superlattices. PMID- 9943018 TI - Metallic surfaces in the Thomas-Fermi-von Weizsacker approach: Self-consistent solution. PMID- 9943019 TI - Schrodinger problem for hierarchical heterostructures. PMID- 9943020 TI - X-ray diffraction study of the metastable charge-density-wave state of K0.3MoO3. PMID- 9943021 TI - Structure of the c(22) coverage of Cl on Ag(100): A controversy resolved by surface extended x-ray-absorption fine-structure spectroscopy. PMID- 9943022 TI - Rapid magnetic oscillations in bis-tetramethyltetraselenafulvalene perchlorate: Possibility of a new type of quantum oscillation. PMID- 9943023 TI - Two-mode radiation from light-emitting tunnel junctions. PMID- 9943024 TI - Third-order electron-correlation and crystal-field contributions to the amplitudes of two-photon absorption in fN systems. PMID- 9943025 TI - Perturbed angular-correlation experiments on 111In in oxidized fcc metals and their oxides. PMID- 9943026 TI - Structural characterization of the sliding charge-density-wave conductor, Rb0.30MoO3, by nuclear magnetic resonance. PMID- 9943027 TI - Electron-spin-resonance study of Pb2 3+ dimer centers in NaCl:PbCl2. PMID- 9943028 TI - Theory of positronium formation at metal surfaces. PMID- 9943029 TI - Crystal-field interactions and spin reorientation in (Er1-xDyx)2Fe14B. PMID- 9943031 TI - Cyclotron-resonance study of polarons in GaAs-AlxGa1-xAs heterostructures. PMID- 9943030 TI - Self-consistent trajectories for surface scattering via classical-quantal coupling. PMID- 9943032 TI - Bipartition model of ion transport: An outline of new range theory for light ions. PMID- 9943033 TI - Critical behavior of vicinal surfaces of 4He. PMID- 9943035 TI - Theory of the Hall effect in heavy-fermion compounds. PMID- 9943034 TI - Pinning by the local changes of the electron mean free path in anisotropic type II superconductors. PMID- 9943036 TI - Dissipation and quantum fluctuations in granular superconductivity. PMID- 9943037 TI - Quantum decay rates for dissipative systems at finite temperatures. PMID- 9943038 TI - Raman study of phonons in Chevrel-phase crystals. PMID- 9943040 TI - Transport measurements in granular niobium nitride cermet films. PMID- 9943039 TI - Nonuniversal breakdown behavior in superconducting and dielectric composites. PMID- 9943041 TI - Nuclear-spin noise and spontaneous emission. PMID- 9943044 TI - Superconductivity of binary and ternary compounds of Bi. PMID- 9943042 TI - Magnetic fluctuations in the magnetically ordering heavy-fermion compounds UCu5 and U2Zn17. PMID- 9943043 TI - Order parameter of superfluid 3He-B near surfaces. PMID- 9943045 TI - Quadrupolar coupling and structural instability in Ho1-xYxCu. PMID- 9943046 TI - Renormalization-group analysis of Lifshitz tricritical behavior. PMID- 9943048 TI - Effect of boundary conditions on the finite-size transverse Ising model. PMID- 9943047 TI - Nonlinear infrared response of antiferromagnets. PMID- 9943049 TI - Measurements of strain and the optical indices in the ferroelectric Ba0.4Sr0.6Nb2O6: Polarization effects. PMID- 9943050 TI - Self-consistent large-N expansion for normal-state properties of dilute magnetic alloys. PMID- 9943051 TI - Bulk, surface, and interface properties of the Ising model and conformal invariance. PMID- 9943054 TI - Molecular relaxation versus orientational ordering of H2 in a-Si:H. PMID- 9943052 TI - Hubbard model for a cubic cluster. PMID- 9943053 TI - Ground state of solid hydrogen at high pressures. PMID- 9943056 TI - Cauchy relations for central-force random networks. PMID- 9943055 TI - Stable trajectories during decomposition of a dilute alloy. PMID- 9943057 TI - Pulsations in optical directional melting of semiconductors. PMID- 9943058 TI - Scaling regimes and functional renormalization for wetting transitions. PMID- 9943060 TI - Specific heat of dilute Au-Fe and Cu-Mn spin-glass alloys below 30 K. PMID- 9943059 TI - Largest current in a random resistor network. PMID- 9943061 TI - NMR observation of temperature-dependent spin-lattice relaxation in trans polyacetylene. PMID- 9943062 TI - Localization, magnetism, and superconductivity in two-dimensional Pd1-yNiyHx films. PMID- 9943063 TI - Magnetic-electron Compton profiles of ferromagnetic Fe and ferrimagnetic Mn ferrite. PMID- 9943064 TI - Behavior of solutions in extended Klein-Gordon systems approaching asymptotically stationary outgoing solitary-wave solutions. PMID- 9943065 TI - Magnetic excitations in the itinerant antiferromagnets Mn3Si and Fe-doped Mn3Si. PMID- 9943066 TI - Kinetics of the complex order parameter in the Landau-Ginzburg model of spontaneous phase transitions. PMID- 9943067 TI - Ruderman-Kittel-Kasuya-Yosida interaction near the surface of a semi-infinite rare-earth metal. PMID- 9943068 TI - Summability of perturbation expansions in disordered systems: Results for a toy model. PMID- 9943069 TI - Theory of orientational relaxation in systems with continuous symmetry. PMID- 9943070 TI - Renormalized finite-cluster expansions. PMID- 9943071 TI - Incommensurate structural modulation and electronic localization in bis tetramethyltetraselenafulvalene thiocyanate. PMID- 9943073 TI - Peierls instability in spinless one-dimensional conductors. PMID- 9943072 TI - Backscattering of electromagnetic waves by a random dielectric medium. PMID- 9943074 TI - Symmetry-adapted Wannier functions in perfect antiferromagnetic chromium. PMID- 9943075 TI - Energy diffusion in disordered electronic systems near the Anderson transition. PMID- 9943076 TI - Electrons trapped in the wake of a negative muon. PMID- 9943078 TI - Raman scattering from Ba2YCu PMID- 9943077 TI - Superconducting transition in thin films of lead telluride doped with thallium. PMID- 9943079 TI - Thermally stimulated luminescence from rare-earth-doped barium copper oxides. PMID- 9943080 TI - Temperature-dependent change of Cu-O bond length in YBa2Cu3O7. PMID- 9943081 TI - Phonon density of states of superconducting YBa2Cu3O7 and the nonsuperconducting analog YBa2Cu3O6. PMID- 9943082 TI - Magnetic and superconducting properties of RBa2Cu PMID- 9943083 TI - Electrodynamic response of Y1Ba2Cu3Oy and La1.85Sr0.15CuO4- delta in the superconducting state. PMID- 9943084 TI - Superconductivity in single-phase Y1Ba PMID- 9943086 TI - Crystal structure and superconductivity of LaBaCu2O PMID- 9943087 TI - Superconductivity in La-Ba-Cu-O metallic oxide compounds above 50 K. PMID- 9943085 TI - Superconductivity in the system (AlxY1-x)Ba2Cu3O6.5+ delta. PMID- 9943089 TI - Peshkov transducer in superfluid 3He. PMID- 9943088 TI - Anomalies in the internal friction and sound velocity in the high-temperature superconductor La1.8Sr0.2CuO4. PMID- 9943091 TI - Spin polarization of secondary electrons from amorphous 3d metallic ferromagnets. PMID- 9943090 TI - Magnetic susceptibility of the Hubbard model in the strong-correlation limit. PMID- 9943092 TI - Neel regions in 180 degrees Bloch walls. PMID- 9943093 TI - Origin of Brown's coercive paradox in perfect ferromagnetic crystals. PMID- 9943094 TI - Effects of temperature on domain-growth kinetics of fourfold-degenerate (21) ordering in Ising models. PMID- 9943096 TI - Segregation of Sn at the Au(110) surface and its effect on the 12 11 phase transition. PMID- 9943095 TI - Quantum spin chains with alternation. PMID- 9943099 TI - Positron mobility edge in dense gaseous helium. PMID- 9943097 TI - Modeling 1/f noise via dynamical random networks. PMID- 9943098 TI - Erratum: Specific-heat measurements on two high-transition-temperature superconducting oxides: La1.85Ba0.15CuO4 and La1.8Sr0.2CuO4 PMID- 9943100 TI - Vector character of light in weak localization: Spatial anisotropy in coherent backscattering from a random medium. PMID- 9943101 TI - Free-carrier relaxation dynamics in the normal state of sintered YBa2Cu3O7-y. PMID- 9943102 TI - Microwave absorption in the superconducting and normal phases of Y-Ba-Cu-O. PMID- 9943104 TI - Temperature dependence of the far-infrared reflectivity spectrum of the high-Tc superconductor YBa2Cu3O7-y. PMID- 9943103 TI - Role of interlayer coupling in oxide superconductors. PMID- 9943105 TI - Photoemission study of YBa2Cu3O7 through the superconducting transition: Evidence for oxygen dimerization. PMID- 9943106 TI - Magnetic fluctuations and two-dimensional ordering in ErBa2Cu PMID- 9943107 TI - Energy gap and Korringa constant in the high-temperature superconductor La1.83Sr0.17CuO4 determined by NMR. PMID- 9943108 TI - Flux pinning and critical current density in YBa2Cu3O6+y and EuBa2Cu3O6+y superconductors. PMID- 9943109 TI - Temperature dependence of the magnetic penetration depth in the high-Tc superconductor Ba2YCu3O9- delta : Evidence for conventional s-wave pairing. PMID- 9943110 TI - Anisotropy of Hc2 and the breadth of the resistive transition of polycrystalline YBa2Cu PMID- 9943111 TI - Upper critical fields and anisotropy limits of high-Tc superconductors R1Ba2Cu3O7 y, where R=Nd, Eu, Gd, Dy, Ho, Er, and Tm, and YBa2Cu3O7-y. PMID- 9943112 TI - Heat capacity of YBa2Cu3O7- delta at the superconducting transition temperature. PMID- 9943113 TI - Measurement of the specific heat anomaly at the superconducting transition of YBa2Cu3O7- delta. PMID- 9943114 TI - Comparison of the pressure dependencies of Tc in the 90-K superconductors RBa2Cu3Ox (R=Gd, Er, and Yb) and YBa2Cu3Ox. PMID- 9943115 TI - Bulk-modulus anomalies at the superconducting transition of single-phase YBa2Cu3O7. PMID- 9943116 TI - Large "forbidden" change in elastic modulus at the superconducting transition of Y1Ba2Cu3O9-x. PMID- 9943117 TI - Persistent current in Ba-Y-Cu-O in liquid nitrogen. PMID- 9943118 TI - Effect of structural changes on the zero-resistance transition temperature of La1Ba2Cu3O9- delta. PMID- 9943120 TI - Oscillations and line shapes of S(Q, omega ) in quantum fluids. PMID- 9943119 TI - Xe and K coadsorption on Ag(110): Observation of a wetting-to-nonwetting phase transition. PMID- 9943121 TI - Tensor-boson condensation in superconductivity of heavy-fermion systems. PMID- 9943123 TI - Point-contact spectra of the heavy-fermion superconductors UBe13 and UPt3. PMID- 9943122 TI - Antiparallel coupling between Fe layers separated by a Cr interlayer: Dependence of the magnetization on the film thickness. PMID- 9943125 TI - Phase transitions in quasicrystalline Al6CuMg PMID- 9943126 TI - Phonon softening and the hydrogen-induced Ni(110) 12 reconstruction. PMID- 9943124 TI - Phase-transition problem and magnetic short-range order in Heisenberg spin glasses. PMID- 9943128 TI - New high-pressure spiral phase of EuAs3. PMID- 9943127 TI - In situ Brillouin scattering from surface-anisotropy-dominated Damon-Eshbach modes in ultrathin epitaxial Fe(110) layers. PMID- 9943129 TI - Mossbauer and magnetization studies of some neptunium heavy-electron intermetallics. PMID- 9943130 TI - Conductivity and noise critical exponents in thin films near the metal-insulator percolation transition. PMID- 9943131 TI - Nonanalytic polarization response of a dipolar glass. PMID- 9943132 TI - Ruderman-Kittel-Kasuya-Yosida interaction in disordered metals. PMID- 9943133 TI - Reevaluation of series expansions for roughening transitions. PMID- 9943134 TI - Noise tolerance of frequency-locked dynamics. PMID- 9943136 TI - Crystal-field splitting in icosahedral symmetry. PMID- 9943135 TI - Electronic structure and properties of NiSi2 and CoSi2 in the fluorite and adamantane structures. PMID- 9943137 TI - Electron-phonon interaction, ultrasonic attenuation, and Eliashberg function alpha 2F( omega ) in impure metals. PMID- 9943139 TI - Phonon-assisted hopping of an electron on a Wannier-Stark ladder in a strong electric field. PMID- 9943138 TI - Interaction of Hg overlayers with an Ag(100) surface. PMID- 9943141 TI - Pressure variation of 4f excitation energies in Eu and Tm metals. PMID- 9943140 TI - Direct observation of atomic structures in the surface reconstruction of Ir and Pt (001), (110), and (131) surfaces. PMID- 9943143 TI - Quantum transport equations for high electric fields. PMID- 9943144 TI - Theory of field evaporation of the surface layer in jellium and other metals. PMID- 9943142 TI - Emissions related to donor-bound excitons in highly purified zinc selenide single crystals. PMID- 9943145 TI - Slow-mode surface plasma oscillations in layered structures. PMID- 9943146 TI - Gutzwiller approach to the Anderson lattice model with no orbital degeneracy. PMID- 9943147 TI - Elastic properties of charge-density-wave conductors in applied electric fields. PMID- 9943149 TI - Metastable defects in hydrogenated amorphous silicon. PMID- 9943148 TI - Deformation potentials at the valence-band maximum in semiconductors. PMID- 9943151 TI - Molecular-dynamics computer simulation of amorphous molybdenum-germanium alloys. PMID- 9943150 TI - First-principles investigation of geometric and electronic structures of aluminum adsorbed on silicon surfaces. PMID- 9943152 TI - Theoretical study of the localization-delocalization transition in amorphous molybdenum-germanium alloys. PMID- 9943153 TI - Electronic structure and properties of d- and f-shell-metal compounds. PMID- 9943154 TI - Mobility enhancement of modulation-doped materials by low-temperature optical annealing of spacer-layer defect charge state. PMID- 9943156 TI - Relativistic corrections to the intrinsic concentration, the effective density of states, and the conductivity in s-dimensional semiconductors. PMID- 9943155 TI - Fluorine-incorporation scheme in fluorinated amorphous silicon prepared by various methods. PMID- 9943157 TI - Infrared-absorption properties of EL2 in GaAs. PMID- 9943158 TI - Microwave-perturbed static-magnetic-field delayed-fluorescence modulation experiments in anthracene. PMID- 9943159 TI - Intervalley scattering and shallow-deep instabilities of electronic levels in semiconductors. PMID- 9943161 TI - Solution of the linearized Boltzmann equation for the two-dimensional electron gas in heterojunctions. PMID- 9943160 TI - Theory of the radical-electron configurations and optical excitations in short chain polydiacetylene oligomers. PMID- 9943162 TI - Atomic and electronic structure of ZnS cleavage surfaces. PMID- 9943164 TI - Attenuated total reflectivity of semiconductors with wave-vector-linear band splitting. PMID- 9943163 TI - Zener transitions in dissipative driven systems. PMID- 9943166 TI - Electronic structure of hydrogenated-fluorinated a-Si1-xGex alloys. PMID- 9943165 TI - Simulation of silicon thermal oxidation. PMID- 9943167 TI - Electron gas in channels in strong magnetic fields. PMID- 9943168 TI - Self-consistent-field studies of core-level shifts in ionic crystals. II. MgO and BeO. PMID- 9943169 TI - Four-photon absorption cross section in potassium bromide at 532 nm. PMID- 9943171 TI - Enhancement of local field by a two-dimensional array of dielectric spheres placed on a substrate. PMID- 9943170 TI - Hydration states and phase transitions in vermiculite intercalation compounds. PMID- 9943173 TI - Quantum resistance fluctuations of a one-dimensional conductor with static disorder. PMID- 9943172 TI - Effect of tip morphology on images obtained by scanning tunneling microscopy. PMID- 9943174 TI - Hot electrons in one dimension: Electron velocity runaway. PMID- 9943175 TI - CdTe thermal parameters studied by single-crystal x-ray diffraction. PMID- 9943176 TI - Localized indirect excitons in a short-period GaAs/AlAs superlattice. PMID- 9943178 TI - Raman spectrum of a ZnSe/GaAs heterostructure. PMID- 9943177 TI - Anomalous exponents in thermally activated random walks. PMID- 9943179 TI - Resonant photoemission from NiI2. PMID- 9943180 TI - Optically detected magnetic-resonance studies of oxygen vacancy defects in the phosphorescent spin quartet state in CaO. PMID- 9943181 TI - Kinetics of ordering in graphite-SbCl5 studied by ESR. PMID- 9943183 TI - Reply to "Comment on 'Atomic structure and ordering in semiconductor alloys' " PMID- 9943182 TI - Comment on "Atomic structure and ordering in semiconducting alloys" PMID- 9943184 TI - Erratum: Acoustic deformation potentials and heterostructure band offsets in semiconductors PMID- 9943185 TI - Coulomb and pinning effects on the soliton-related phonon modes in polyacetylene. PMID- 9943186 TI - Elastic properties of charge-density-wave conductors. PMID- 9943188 TI - 5f-band width and resonant photoemission of uranium intermetallic compounds. PMID- 9943187 TI - Photochromism and photoinduced bond-structure change in the conjugated polymer polydiacetylene. PMID- 9943190 TI - Altshuler-Aronov anomalies in the density of states of substitutional alloys. PMID- 9943189 TI - Empirical electron-phonon lambda values from resistivity of cubic metallic elements. PMID- 9943191 TI - Avoided crossing of vibrational modes in Ag(110) observed by He time-of-flight measurements. PMID- 9943192 TI - Nonlinear ac dynamics of pinned charge-density waves: Third-harmonic generation. PMID- 9943193 TI - Momentum-mixing-induced enhancement of band nonparabolicity in GaAs-Ga1-xAlxAs superlattices. PMID- 9943195 TI - Effects of compressive uniaxial stress on the electronic structure of GaAs-Ga1 xAlxAs quantum wells. PMID- 9943194 TI - Detection of deep-lying defects in a-SiH:C alloy films. PMID- 9943196 TI - Saddle-point excitons in solids and superlattices. PMID- 9943197 TI - Infrared spectral hole burning of sulfur-hydrogen deep donors in a Si:Ge crystal. PMID- 9943198 TI - Carrier cooling in undoped and modulation-doped Ga0.47In0.53As multiple quantum wells. PMID- 9943199 TI - Charge transfer in Hg1-xCdxTe-CdTe heterostructures. PMID- 9943200 TI - Deep-level symmetry studies using ballistic-phonon transmission in undoped semi insulating GaAs. PMID- 9943201 TI - Metastable paramagnetism in hydrogenated amorphous silicon: Evidence for a new class of defects in tetrahedrally bonded amorphous semiconductors. PMID- 9943202 TI - Shear modulus of TaS3. PMID- 9943203 TI - L2 and L3 measurements of transition-metal 5d orbital occupancy, spin-orbit effects, and chemical bonding. PMID- 9943204 TI - Identification of C-H resonances in the K-shell excitation spectra of gas-phase, chemisorbed, and polymeric hydrocarbons. PMID- 9943205 TI - Non-Markovian line shapes of physisorbed atoms on a crystal. PMID- 9943207 TI - Localization in one-dimensional disordered systems with electric field: An analytical approach. PMID- 9943206 TI - Surface-phonon dispersion on Cu(110): A comparison of experiment and theory. PMID- 9943209 TI - Order and disorder in iron-titanium. PMID- 9943210 TI - Nonlocal theory for surface-plasmon excitation in simple metals. PMID- 9943208 TI - Incident beam effects in medium-energy backscattered electron diffraction. PMID- 9943212 TI - Scattering of phonons by dislocations in potassium. PMID- 9943211 TI - Stability of solitary-wave pulses in shape-memory alloys. PMID- 9943213 TI - Surface-plasmon-polariton mode conversion on rough interfaces. PMID- 9943214 TI - Photodesorption by resonant laser-vibrational coupling: Effects of coherent two quantum transitions, vibrational anharmonicity, and surface heterogeneity on yields. PMID- 9943215 TI - Localization, Coulomb interaction, and spin-orbit scattering in amorphous Cu-Ti Au alloys. PMID- 9943216 TI - Chemical and surface core-level shifts of barium studied by photoemission. PMID- 9943217 TI - Theory of classical diffusion jumps in solids. II. Isotope effect and first-order anharmonic terms. PMID- 9943218 TI - Exact Kohn-Sham direct gap at an insulator-metal transition. PMID- 9943219 TI - Semiempirical band structure of PtGa2. PMID- 9943220 TI - Structure of segregated Au layers on Ni(110)-0.8 at. % Au alloy by scanning tunneling microscopy. PMID- 9943221 TI - Screened dielectric response of sliding charge-density waves. PMID- 9943222 TI - Many-body tetrahedral-cluster model for binary and ternary alloys. PMID- 9943223 TI - Infrared optical properties and vibrational behavior of anisotropic crystals: Orthorhombic Ba PMID- 9943224 TI - Weak localization in inhomogeneous magnetic fields. PMID- 9943225 TI - X-ray scattering and condensed-matter experiments: Beyond the nonrelativistic approach. PMID- 9943226 TI - Charge-density-wave phase transition in the quasi-one-dimensional conductor Nb3Te PMID- 9943228 TI - Anharmonic dynamics of defect pairs in soft-mode systems. PMID- 9943227 TI - Prototype fcc-based binary-alloy phase diagrams from tight-binding electronic structure calculations. PMID- 9943229 TI - Ab initio calculations of the cohesive energy of Mo and W and heat of formation of MoSi2 and WSi2. PMID- 9943230 TI - Path-integral method for a heavy particle moving in a periodic potential and screened by a light degenerate Fermi gas. PMID- 9943231 TI - Electronic structure of ZnS, ZnSe, ZnTe, and their pseudobinary alloys. PMID- 9943232 TI - Ab initio (GaAs)3(AlAs)3 (001) superlattice calculations: Band offsets and formation enthalpy. PMID- 9943233 TI - New formalism of the Kronig-Penney model with application to superlattices. PMID- 9943235 TI - Laser-induced free-carrier and temperature gratings in silicon. PMID- 9943234 TI - Carrier confinement potential in quantum-well wires fabricated by implantation enhanced interdiffusion in the GaAs-Ga1-xAlxAs system. PMID- 9943236 TI - Interband transitions of thin-layer GaAs/AlAs superlattices. PMID- 9943238 TI - Excitation gap in the fractionally quantized Hall effect. PMID- 9943237 TI - Hydrogen microstructure in amorphous hydrogenated silicon. PMID- 9943239 TI - Ground-state energy of a shallow donor in a polar-crystal interface. PMID- 9943240 TI - Soliton mobility in trans-polyacetylene. PMID- 9943242 TI - Cyclotron resonance of polarons in a nonparabolic band. PMID- 9943241 TI - Adsorption on narrow-gap semiconductors. PMID- 9943243 TI - Photoelectron spectra from local-density-functional calculations: Application to chain polymers. PMID- 9943245 TI - Characterization of a-Si:H/a-Ge:H superlattices by Raman scattering. PMID- 9943244 TI - Structural properties of GeTe at T=0. PMID- 9943246 TI - Angle-resolved photoemission study of the alpha -Sn/CdTe(100) interface. PMID- 9943247 TI - Effect of grain boundaries on the Raman spectra, optical absorption, and elastic light scattering in nanometer-sized crystalline silicon. PMID- 9943248 TI - Electronic structure of a neutral Cu-related complex defect with a bound exciton at 2.3296 eV in ZnTe. PMID- 9943250 TI - Radiation-enhanced impurity aggregation in MgO. PMID- 9943251 TI - Polyazacetylene: Metallic conductor versus Mott insulator. PMID- 9943249 TI - Dispersion relation and critical wave vector of surface plasmons in a semi infinite superlattice. PMID- 9943253 TI - High-pressure structural and electronic properties of carbon. PMID- 9943252 TI - Off-normal infrared reflectivity in uniaxial crystals: alpha -LiIO PMID- 9943255 TI - Nature of defect structure in CoO. PMID- 9943254 TI - Elastic neutron scattering studies of the structure of graphite intercalated with potassium and ammonia. PMID- 9943256 TI - Calculated properties of monolayer and multilayer N2 on graphite. PMID- 9943257 TI - Predicted properties of the uniaxially incommensurate phase of N2 monolayers on graphite. PMID- 9943258 TI - Surface electronic structure and chemisorption on corundum transition-metal oxides: alpha -Fe2O3. PMID- 9943260 TI - Optical properties, reflectance, and transmittance of anisotropic absorbing crystal plates. PMID- 9943259 TI - Low-temperature ultrasonic attenuation by strongly dispersive transverse-acoustic phonons in alpha -quartz. PMID- 9943261 TI - Optical linewidths and photon-echo decays of impurities in glasses. PMID- 9943263 TI - Vibrational modes of a DNA polymer at low temperature. PMID- 9943262 TI - Resonant Raman scattering in stage-1 graphite acceptor intercalated compounds: C AsF5. PMID- 9943265 TI - Electronic shell structure of simple metal heteroclusters. PMID- 9943264 TI - Work function of metals upon alkali-metal adsorption: Overlayer relaxation. PMID- 9943266 TI - Quantum size effect in superlattices. PMID- 9943267 TI - Temperature effects in atomic diffusion in silicon. PMID- 9943268 TI - Nonlocal Kohn-Sham exchange corrections to Si band gaps and binding energy. PMID- 9943269 TI - Hartree-Fock energies for NaF6 cluster simulations of Na+ hole states in the NaF crystal. PMID- 9943270 TI - Folded acoustic phonons in (Al,Ga)As quasiperiodic superlattices. PMID- 9943272 TI - Defect dynamics and the Staebler-Wronski effect in hydrogenated amorphous silicon. PMID- 9943271 TI - Transport studies of protonated emeraldine polymer: A granular polymeric metal system. PMID- 9943273 TI - Evolution upon doping of the pi and sigma bands of poly-(3-methylthiophene) grafted on Pt electrodes as studied by near-edge x-ray-absorption fine-structure spectroscopy. PMID- 9943275 TI - Acoustic-phonon transmission in quasiperiodic superlattices. PMID- 9943274 TI - Photoreflectance and photoreflectance-excitation spectroscopy of a GaAs/Ga0.67Al0.33As multiple-quantum-well structure. PMID- 9943276 TI - Direct evidence of the onset of In surface segregation for Co/InP(110). PMID- 9943278 TI - Spectral hole burning by population storage in Zeeman sublevels of LaFsub3:Nd3+ PMID- 9943277 TI - Zone-center phonon frequencies for graphite and graphite intercalation compounds: Charge-transfer and intercalate-coupling effects. PMID- 9943279 TI - Energy and angular distributions of Rh atoms ejected due to ion bombardment from Rh{111}: A theoretical study. PMID- 9943280 TI - Impurity energy levels and stability of Cr and Mn ions in cubic BaTiO3. PMID- 9943281 TI - Electron-nuclear double resonance of interstitial chromium in silicon. PMID- 9943282 TI - EPR of Co2+-doped NiSO4 PMID- 9943283 TI - Zero-current persistent potential drop across small-capacitance Josephson junctions. PMID- 9943284 TI - Renormalization method for the resistive transition in Josephson networks. PMID- 9943285 TI - Anomalous behavior of superconducting samples with a fixed number of vortices. PMID- 9943286 TI - Internal structure of a Landau quasiparticle wave packet. PMID- 9943287 TI - Continuous-wave NMR in spin-polarized atomic hydrogen. PMID- 9943288 TI - Ginzburg-Landau theory of vortices in superfluid 3He-B. PMID- 9943289 TI - Simple model for the equilibrium shape of 4He crystals. PMID- 9943290 TI - Influence of magnetic rare-earth ion substitution on the magnetic susceptibility of high-Tc superconductors. PMID- 9943291 TI - Oxygen ordering and the orthorhombic-to-tetragonal phase transition in YBa2Cu PMID- 9943293 TI - Upper bound on the specific-heat jump: Application to the high-Tc oxides. PMID- 9943292 TI - Structural properties of Ba2RCu PMID- 9943294 TI - Thermodynamic and other properties of La1.85Sr0.15CuO4. PMID- 9943295 TI - Upper critical field for a high-Tc electron-phonon superconductor: Regime of Tc/ omega 1n~1. PMID- 9943296 TI - Influence of a magnetic field on the two-dimensional phase transition in thin film superconductors. PMID- 9943297 TI - Quantum effects and the dissipation by quasiparticle tunneling in arrays of Josephson junctions. PMID- 9943298 TI - Electronic properties of the half-metallic ferromagnetic NiUSn. PMID- 9943299 TI - Temperature dependence of the conductivity and the susceptibility in metallic Si:P reanalyzed from the paramagnon point of view. PMID- 9943300 TI - ac response near the percolation threshold: Transfer-matrix results in two and three dimensions. PMID- 9943301 TI - Solid physically adsorbed films: A Potts lattice-gas-model study. PMID- 9943303 TI - Square-lattice Ising model in a weak uniform magnetic field: Renormalization group analysis. PMID- 9943302 TI - Nucleation-field distribution of the Bloch-wall polarization reversal process. PMID- 9943304 TI - Commensuration and discommensuration in 2H-TaSe PMID- 9943305 TI - Critical behavior of a new class of statistical-mechanical models with continuous variables and discretely valued interactions. PMID- 9943306 TI - Determination of the glass-forming concentration range in binary alloys from a semiempirical theory: Application to Zr-based alloys. PMID- 9943307 TI - Binary phase diagrams of H2-He mixtures at high temperature and high pressure. PMID- 9943308 TI - Relativistic theory of neutron form factors. PMID- 9943310 TI - Brillouin scattering studies of the ferroelastic phase transition in LiCsSO4. PMID- 9943309 TI - Relationships between local order and magnetic behavior in amorphous Fe0.30Y0.70: Extended x-ray-absorption fine structure and susceptibility. PMID- 9943311 TI - Crossover renormalization-group approach to semi-infinite inhomogeneous critical behavior. PMID- 9943312 TI - Effect of adsorbates on the spin-polarized photoemission of itinerant ferromagnets. PMID- 9943313 TI - Spin-spin correlations in finite systems with O(n) symmetry: Scaling hypothesis and corrections to bulk behavior. PMID- 9943315 TI - Classical Heisenberg ferromagnet in two dimensions. PMID- 9943314 TI - Local spin and orbital moment in Nd2Fe14B and Y2Fe17. PMID- 9943316 TI - Mapping between random central-force networks and random resistor networks. PMID- 9943317 TI - Ground state of nuclear spins in fcc metals. PMID- 9943318 TI - Synthesis of band and model Hamiltonian theory for hybridizing cerium systems. PMID- 9943319 TI - Supersymmetrical approach to critical dynamics of relaxational models. PMID- 9943320 TI - Phenomenological theory of the magnetic transitions in CsNiCl3. PMID- 9943322 TI - Ferromagnetic random-bond Ising model: Metastable states and complexity of the energy surface. PMID- 9943321 TI - Calculation of specific heat and susceptibilities with the use of the Trotter approximation. PMID- 9943324 TI - Optical study of structural phase transition in organic charge-transfer crystals K- and Rb-tetracyanoquinodimethane. PMID- 9943323 TI - Percolation in spatially disordered systems. PMID- 9943325 TI - Elastic behavior of magnetic systems with a narrow twofold-degenerate band. PMID- 9943326 TI - Diffusion on fractals with singular waiting-time distribution. PMID- 9943327 TI - Separate migration and formation energies of vacancies in aluminum measured by NMR. PMID- 9943328 TI - Infrared molecular-vibration spectra of tetrathiafulvalene-chloranil crystal at low temperature and high pressure. PMID- 9943329 TI - Nuclear-magnetic-resonance evidence for a new phase induced by pressure in the superionic conductor Li3N. PMID- 9943330 TI - X-ray absorption measurements on high-Tc superconductors: Cu-valence and cation bond-length effects. PMID- 9943331 TI - High-temperature superconductivity in the presence of O 2p-Cu 3d holes: A spectroscopic study. PMID- 9943332 TI - Unoccupied electronic states and surface phenomena for YBa2Cu3O6.9. PMID- 9943333 TI - Oxygen-vacancy behavior in La2-xSrxCuO4-y by positron annihilation and oxygen diffusion. PMID- 9943334 TI - Microwave study of the high-Tc superconductor La1.8Sr PMID- 9943335 TI - Electron tunneling in the high-Tc superconductor Y-Ba-Cu-O. PMID- 9943336 TI - Normal-state properties of ABa2Cu3O7-y compounds (A=Y and Gd): Electron-electron correlations. PMID- 9943337 TI - Thermal conductivity of superconductive Y-Ba-Cu-O. PMID- 9943339 TI - Effects of substitution of O by S and Cu by Fe on superconductivity in YBa2Cu PMID- 9943338 TI - Twins and oriented domains in the orthorhombic superconductor YBa2Cu PMID- 9943341 TI - Critical fluctuations in high-Tc superconductors. PMID- 9943340 TI - Band-theory analysis of anisotropic transport in La2CuO PMID- 9943342 TI - Electron-phonon interaction in two dimensions: The case for strong coupling in high-Tc superconductors. PMID- 9943343 TI - Thermodynamic and other properties of a high-Tc excitonic superconductor. PMID- 9943344 TI - Superconductivity in shocked Cu2Mo6S8. PMID- 9943345 TI - Single-crystal x-ray diffraction of n-H2 at high pressure. PMID- 9943346 TI - Ruderman-Kittel-Kasuya-Yosida range function of a one-dimensional free-electron gas. PMID- 9943348 TI - Comparison of the S=(1/2 xy and antisymmetric exchange chains in an external field. PMID- 9943347 TI - Series analysis of randomly diluted nonlinear networks with negative nonlinearity exponent. PMID- 9943349 TI - Remanence on microscopic and macroscopic scales in the reentrant spin glass EuxSr1-xS. PMID- 9943350 TI - Critical behavior of Young's modulus for two-dimensional randomly holed metallized Mylar. PMID- 9943351 TI - Gap exponents determined from the pressure measurements of the nonlinear electric permittivity for triglycine sulfate in the paraelectric region. PMID- 9943352 TI - Erratum: Multilayer phase diagram of CF4 adsorbed on graphite PMID- 9943353 TI - Erratum: Crystallographic description of phases in the Y-Ba-Cu-O superconductor PMID- 9943355 TI - Inverse photoemission studies of the empty electronic states and surface stability of La1.85Sr0.15CuO4. PMID- 9943354 TI - Valence electronic structure of Y1Ba2Cu PMID- 9943356 TI - Reaction and disruption for Fe/La1.85Sr PMID- 9943358 TI - Soft x-ray absorption studies on high-Tc superconducting oxides. PMID- 9943357 TI - Oxygen withdrawal, copper valency, and interface reaction for Fe/La1.85Sr0.15CuO4. PMID- 9943359 TI - Effects of oxygen stoichiometry on the electronic structure of YBa2Cu PMID- 9943360 TI - Complete absence of isotope effect in YBa2Cu3O7: Consequences for phonon-mediated superconductivity. PMID- 9943362 TI - Quasiparticle excitations in the superconducting state observed in light scattering. PMID- 9943361 TI - Positron annihilation in the high-temperature superconductor YBa2Cu3O6+ delta. PMID- 9943363 TI - Vibrational spectra and lattice instabilities in the high-Tc superconductors YBa2Cu3O7 and GdBa2Cu3O7. PMID- 9943364 TI - Critical fields and the critical current density of La1.85Sr PMID- 9943366 TI - Low-field magnetic relaxation effects in high-Tc superconductors Sr-La-Cu-O and Ba-La-Cu-O. PMID- 9943365 TI - Influence of oxygen defects on the physical properties of La2CuO PMID- 9943368 TI - Magnetic ordering in GdBa2(Cu0.94Fe0.06)3O9- delta below the superconducting transition temperature. PMID- 9943367 TI - Longitudinal and transverse magnetoresistances of YBa2Cu3O7 in very high field up to 430 kG. PMID- 9943370 TI - Superconducting properties of aligned crystalline grains of Y1Ba2Cu3O7- delta. PMID- 9943369 TI - Large anisotropic critical magnetization currents in single-crystal YBa2Cu3O7- delta. PMID- 9943371 TI - Magnetism and critical fields in the high-Tc superconductors YBa2Cu3O7-xSx (x=0,1): An ESR study. PMID- 9943372 TI - Magnetic properties of Y-Ba-Cu-O superconductors. PMID- 9943374 TI - Structural and superconducting properties of orientation-ordered Y1Ba2Cu3O7-x films prepared by molecular-beam epitaxy. PMID- 9943373 TI - Superconductivity in bulk and thin films of La1.85Sr PMID- 9943375 TI - Evidence for antiferromagnetic interactions in the high-temperature superconductor La1.85Sr PMID- 9943377 TI - Linear temperature behavior of the resistivity in the new high-Tc superconductors. PMID- 9943376 TI - Correlation of Tc with hole concentration in La2-xSrx PMID- 9943378 TI - Direct evidence for positron annihilation from shallow traps. PMID- 9943379 TI - Local-density prediction of the Fermi surface of UBe13. PMID- 9943380 TI - Quasireentrant superconductivity near the metal-insulator transition of granular aluminum. PMID- 9943382 TI - Spin dynamics of paramagnetic nickel. PMID- 9943381 TI - Magnetic phase diagram of the half-filled Hubbard model for a simple cubic lattice. PMID- 9943383 TI - Structure determination for the intermediate-density S2 monolayer phase of ethane physisorbed on graphite. PMID- 9943384 TI - Dielectric breakdown in the presence of random conductors. PMID- 9943385 TI - Liquid-to-vapor homogeneous nucleation in liquid nitrogen. PMID- 9943386 TI - Ce(Cu0.9Ag0.1)6: Highest electronic specific-heat coefficient of the heavy fermion systems. PMID- 9943387 TI - Frequency and temperature dependence of conduction-electron spin resonance in a highly enhanced-susceptibility metal: TiBe2. PMID- 9943388 TI - Electron-phonon interaction effects in tantalum. PMID- 9943389 TI - All-electron local-density-functional theory of alkali-metal adsorption on transition-metal surfaces: Cs on Mo(001). PMID- 9943390 TI - Ion energy distributions from photon- and electron-stimulated desorption. II. The quasiclassical final state and reneutralization. PMID- 9943391 TI - Dephasing and Anderson localization in topologically disordered systems. PMID- 9943392 TI - Photoemission investigation of the electronic structure of amorphous and crystalline FexZr100-x (x=25,33,91). PMID- 9943393 TI - Nucleation calculations in a pair-binding model. PMID- 9943394 TI - First-principles calculations of the phase diagrams of noble metals: Cu-Au, Cu Ag, and Ag-Au. PMID- 9943396 TI - Numerical study of conductance fluctuations in disordered metals. PMID- 9943395 TI - Solid-solution strengthening: Substitution of V in Ni3Al and structural stability of Ni3(Al,V). PMID- 9943398 TI - Transmission and reflection times for scattering of wave packets off tunneling barriers. PMID- 9943397 TI - Finite-size effects in the electrical conduction of thin wires. PMID- 9943400 TI - Electronic mechanism of orthorhombic phase formation in some AIVB PMID- 9943399 TI - Three-dimensional quantum-size effect in chemically deposited cadmium selenide films. PMID- 9943401 TI - Amorphous-silicon formation by rapid quenching: A molecular-dynamics study. PMID- 9943403 TI - Phonon-drag effect in TiSe2-xSx mixed compounds. PMID- 9943402 TI - Thermal-noise temperature of GaAs heterosystems for steady-state hot-electron transport with nonequilibrium phonons. PMID- 9943404 TI - Bolometric infrared spectra of (TaSe4)2I. PMID- 9943405 TI - Dopant-type effects on the diffusion of deuterium in GaAs. PMID- 9943406 TI - Constraint theory and carrier-type reversal in Bi-Ge chalcogenide alloy glasses. PMID- 9943407 TI - Electrolyte electroreflectance study of the band offset in a GaAs/Ga0.69Al0.31As superlattice. PMID- 9943408 TI - Quasichemical approximation in binary alloys. PMID- 9943409 TI - Polarization dependence of transient photoconductivity in trans-polyacetylene. PMID- 9943410 TI - Absorption spectroscopy on Ga0.47In0.53As/Al0.48LIn0.52As multi-quantum-well heterostructures. I. Excitonic transitions. PMID- 9943411 TI - Absorption spectroscopy on Ga0.47In0.53As/Al0.48In0.52As multi-quantum-well heterostructures. II. Subband structure. PMID- 9943412 TI - Raman scattering from superlattices of diluted magnetic semiconductors. PMID- 9943414 TI - Electronic excitations in finite and infinite polyenes. PMID- 9943413 TI - Theory of the absorption of electromagnetic radiation by hopping in p-type Hg1 xMnxTe in strong magnetic fields. PMID- 9943415 TI - Gamma -X mixing in GaAs/AlxGa1-xAs and AlxGa1-xAs/AlAs superlattices. PMID- 9943416 TI - Tight-binding theory and elastic constants. PMID- 9943417 TI - Photoinduced interlayer diffusion in a-Ge/Se multilayers. PMID- 9943418 TI - High-temperature mobility of pure n-type InP epitaxial layers. PMID- 9943419 TI - Vibrational properties of the amide group in acetanilide: A molecular-dynamics study. PMID- 9943420 TI - Lattice dynamics of TiC(110) and TiC(111) surfaces. PMID- 9943421 TI - "Giant resonances" in luminescence soft-x-ray excitation spectra of phosphors. PMID- 9943422 TI - Inverse dielectric response function of a dielectric sphere. PMID- 9943423 TI - Evidence of electronic shell structure in RbN + (N=1-100) produced in a liquid metal ion source. PMID- 9943424 TI - Local-density-functional calculation of electrodynamic surface response. PMID- 9943425 TI - Multiphoton excitations in neodymium chlorides. PMID- 9943426 TI - He diffraction from W(112): A quantitative analysis. PMID- 9943427 TI - Partial densities of states of alloys: Cu3Au. PMID- 9943428 TI - Molecular-orbital interaction in isolated transition-metal atoms. PMID- 9943429 TI - Electrical transport properties and crystal structure of LiZnAs. PMID- 9943431 TI - Atomic reconstruction of the silicon (230) surface. PMID- 9943430 TI - Scaling relations between the two- and three-dimensional polarons for static and dynamical properties. PMID- 9943432 TI - Neutron-diffraction studies of BaC6: c-axis compressibility, carbon-carbon bond length, and charge transfer. PMID- 9943433 TI - Comment on "Comprehensive analysis of Si-doped AlxGa1-xAs (x=0 to 1): Theory and experiments" PMID- 9943434 TI - Reply to "Comment on 'Comprehensive analysis of Si-doped AlxGa1-xAs (x=0 to 1): Theory and experiments' " PMID- 9943435 TI - Comment on "Self-consistent-average-phonon equation of state. II. Comparison with solid-rare-gas experiments" PMID- 9943436 TI - Extreme-ultraviolet light emission from 50-MeV H0 impact on aluminum. PMID- 9943437 TI - Characteristic times for resonant tunneling in one dimension. PMID- 9943439 TI - Verification of the Esbjerg-No PMID- 9943438 TI - Effect of partial phase coherence on Aharonov-Bohm oscillations in metal loops. PMID- 9943440 TI - Electronic structure of a quasiperiodic system. PMID- 9943441 TI - Measurements of surface phonon frequencies on Al(110) for comparison with recent ab initio calculations. PMID- 9943443 TI - Wave-vector dispersion versus angular-momentum dispersion of collective modes in small metal particles. PMID- 9943442 TI - Quantitative "local-interference" model for 1/f noise in metal films. PMID- 9943444 TI - Formation of large local magnetic moments at the Cr/Au(100) interface: Evidence for a diffuse interface. PMID- 9943446 TI - Experimental test of the photoemission of adsorbed xenon model. PMID- 9943445 TI - Multiple-tip interpretation of anomalous scanning-tunneling-microscopy images of layered materials. PMID- 9943447 TI - Self-energy corrections in photoemission of Na. PMID- 9943449 TI - Thermoelectric power fluctuations. PMID- 9943448 TI - Normal versus exchange inelastic electron scattering in metals: Theory and experiment. PMID- 9943450 TI - Coverage dependence of the work function and charge transfer on the alkali-metal jellium surface. PMID- 9943451 TI - Universal conductance fluctuations and electron coherence lengths in a narrow two dimensional electron gas. PMID- 9943452 TI - Exciton states in strained quantum wells. PMID- 9943453 TI - Percolative aspects in photoconductivity. PMID- 9943454 TI - Light-induced changes of phosphorus bonding configurations in hydrogenated amorphous silicon. PMID- 9943455 TI - Fractional quantum Hall effect in tilted magnetic fields. PMID- 9943456 TI - Photocapacitance study of pressure-induced deep donors in GaAs:Si. PMID- 9943457 TI - Effects of band structure on the energy exchange rate between quasithermal electron and hole distributions in semiconductors. PMID- 9943459 TI - Phase transitions in GaSb to 110 GPa (1.1 Mbar). PMID- 9943458 TI - Structure of the boron-hydrogen complex in crystalline silicon. PMID- 9943460 TI - New optical transitions in strained Si-Ge superlattices. PMID- 9943462 TI - Raman scattering by acoustic phonons in Fibonacci GaAs-AlAs superlattices. PMID- 9943461 TI - Shubnikov-de Haas effect in submicron-width GaAs/Ga1-xAlxAs heterojunction wires. PMID- 9943463 TI - Resonance-induced quenching of luminescence and reduction of tunneling time in AlxGa1-xAs/GaAs multiple-quantum-well structures. PMID- 9943465 TI - Transition from one- to two-dimensional fluctuating variable-range-hopping conduction in microstructures. PMID- 9943464 TI - Effect of electric fields on excitons in a coupled double-quantum-well structure. PMID- 9943466 TI - Structure of laser-pulse-plasma-induced carbon clusters: Explanation of the magic numbers. PMID- 9943467 TI - ESR study of the electrochemical doping of polyacetylene with potassium. PMID- 9943469 TI - Ring exchange and the fractional quantum Hall effect. PMID- 9943468 TI - Positive-ion production by electron bombardment of alkali halides. PMID- 9943470 TI - Hyperfine-field spectrum of epitaxially grown bcc cobalt. PMID- 9943471 TI - Secondary relaxations due to fast-ion diffusion in AgI-rich borate glasses observed by Brillouin scattering. PMID- 9943473 TI - Nonlocal dipole model for the phonon dispersion in diamond-type lattices. PMID- 9943472 TI - Extended x-ray-absorption fine-structure study of amorphous (NixPt100-x)75P25 alloys. PMID- 9943474 TI - Configurational energies and effective cluster interactions in substitutionally disordered binary alloys. PMID- 9943475 TI - Conduction-electron Zeeman splitting on the X-pocket holes in platinum. PMID- 9943476 TI - Individual formation parameters of charged point defects in ionic crystals: Silver chloride. PMID- 9943478 TI - Energy-transfer theory for the classical decay rates of molecules at rough metallic surfaces. PMID- 9943477 TI - Local-density approach for calculation of electron-positron enhancement in transition metals. PMID- 9943480 TI - Angle-resolved photoemission study of the electronic band structure of the ZrC(100) surface. PMID- 9943479 TI - Thermal desorption of atoms from surfaces. PMID- 9943481 TI - Surface segregation and relaxation calculated by the embedded-atom method: Application to face-related segregation on platinum-nickel alloys. PMID- 9943483 TI - Singular behavior of phonon-phonon interactions in molecular crystals. PMID- 9943482 TI - Ab initio calculation of the lattice specific heat of lithium. PMID- 9943484 TI - Filling three-dimensional space with tetrahedra: A geometric and crystallographic problem. PMID- 9943485 TI - Change of the density of electron states caused by the surface of a layered crystal structure. PMID- 9943486 TI - Extended x-ray-absorption fine-structure study of the annealing effect on glassy Pd76B24: Comparison with x-ray diffraction and modeling results. PMID- 9943488 TI - Conductivity of n-type GaAs near the Mott transition. PMID- 9943487 TI - GaSb-InAs-GaSb heterostructures studied under hydrostatic pressure. PMID- 9943489 TI - Temperature-dependent interface evolution: Modeling of core-level photoemission results for V/Ge(111). PMID- 9943490 TI - Core-level binding-energy shifts, thermodynamic predictions, and morphologies for metal-Si and metal-Ge interfaces. PMID- 9943491 TI - Structure determination of the CoSi2:Si(111) interface by x-ray standing-wave analysis. PMID- 9943492 TI - Molecular-dynamics simulation of molecular-beam epitaxial growth of the silicon (100) surface. PMID- 9943493 TI - Renormalization formalism in the theory of the electronic structure of superlattices: Application to silicon superlattices. PMID- 9943494 TI - Cyclotron-resonance study of nonparabolicity and screening in GaAs-Ga1-xAlxAs heterojunctions. PMID- 9943495 TI - Electrodynamics of superlattices: Formalism. PMID- 9943496 TI - Effect of an applied magnetic field on interface excitations in finite layered structures. II. PMID- 9943497 TI - Temperature dependence of the interband critical-point parameters of InP. PMID- 9943498 TI - Temperature dependence of the dielectric function and interband critical points in silicon. PMID- 9943499 TI - Electronic structure of the 2.3149-eV complex defect in Ag-doped ZnTe. PMID- 9943500 TI - Effective-mass Hamiltonians for abrupt heterojunctions in three dimensions. PMID- 9943502 TI - Electronic properties and optical-absorption spectra of graded-gap GaAs-AlxGa PMID- 9943501 TI - Pressure dependence of deep electronic levels in semiconductors: The oxygen vacancy pair (or A center) in silicon. PMID- 9943504 TI - Light scattering from quantum confined and interface optical vibrational modes in strained-layer GaSb/AlSb superlattices. PMID- 9943503 TI - Frequency gaps for acoustic phonons in a-Si:H/a-SiNx:H superlattices. PMID- 9943506 TI - Multivalley electron gas in a strong magnetic field. PMID- 9943505 TI - Self-energy shifts in heavily doped, polar semiconductors. PMID- 9943507 TI - Stark shifts on exciton luminescence in quantum wells: Effect of Coulomb interaction. PMID- 9943508 TI - Phonon modes and Raman scattering in GaAs/Ga1-xAlxAs. PMID- 9943509 TI - Elastic constants of a superionic alpha -AgI single crystal determined by Brillouin scattering. PMID- 9943511 TI - Estimate of the barrier to and rate of dissociation of dense nitrogen under shock conditions. PMID- 9943510 TI - Elastic constants of a solid-electrolyte fcc Li2SO4 single crystal obtained by Brillouin scattering. PMID- 9943512 TI - Raman scattering study of the high-frequency graphitic intralayer modes in Li graphite and the stage dependence of the mode frequency in donor graphite intercalation compounds. PMID- 9943513 TI - Oblique-incidence absorption spectroscopy studies of the plasmon in potassium halides. PMID- 9943514 TI - Ionic and superionic conductivities of SrF2 crystals in a wide frequency range. PMID- 9943515 TI - Decay of the Na 2p core exciton in sodium halides studied by photoelectron spectroscopy. PMID- 9943516 TI - Exact evaluation of the Kubo formula for boundary resistance. PMID- 9943517 TI - Effects of gas-phase collisions on particles rapidly desorbed from surfaces. PMID- 9943518 TI - Calculation of the barrier for oxygen incorporation into metal and metal-oxide surfaces. PMID- 9943519 TI - Dipole radiation in a multilayer geometry. PMID- 9943520 TI - Absolute cross sections for hyper-Raman scattering by soft modes in oxygen octahedra ferroelectrics. PMID- 9943521 TI - pi bonding in the icosahedral C60 cluster. PMID- 9943522 TI - Hot-phonon effects in bulk GaAs. PMID- 9943523 TI - Comparative investigation of temperature-induced phonon-frequency shifts in CeSn3 and LaSn3. PMID- 9943524 TI - Asymptotic structure of the Slater-exchange potential at metallic surfaces. PMID- 9943527 TI - Monte Carlo calculation of the thermal expansion coefficient of Al. PMID- 9943525 TI - Separation of plasmon-polariton modes of small metal particles. PMID- 9943526 TI - Conductance fluctuations in small disordered conductors: Thin-lead and isolated geometries. PMID- 9943529 TI - Functionals of the ground-state energy and the band gaps of semiconductors and insulators. PMID- 9943528 TI - Structure analysis of Ge(111)11-H by low-energy electron diffraction. PMID- 9943531 TI - Lattice mechanics of monovalent metal nitrates. PMID- 9943530 TI - Ionicity in AIIB PMID- 9943532 TI - Electronic structure of the 1.429-eV complex neutral defect in GaAs from tunable dye-laser spectroscopy. PMID- 9943533 TI - Impact ionization of excitons and electron-hole droplets in silicon. PMID- 9943534 TI - PGa-antisite-related neutral complex defect in GaP studied with optically detected magnetic resonance. PMID- 9943535 TI - Quantum theory of the cyclotron-resonance line shape in the presence of hole phonon interactions in p-type multi-quantum-well structures. PMID- 9943536 TI - Impurity-shifted polaron energy in semimagnetic Cd1-xMnxTe-CdTe quantum wells. PMID- 9943537 TI - Self-consistent calculation of the electronic properties of a selectively doped AlxGa1-xAs-GaAs quantum well under high magnetic fields. PMID- 9943539 TI - Temporal fluctuations in wave propagation in random media. PMID- 9943538 TI - Optical-density effect in heterodyne-detected accumulated photon echo. PMID- 9943541 TI - Interaction of slow electrons with density fluctuations in condensed materials: Calculation of stopping power. PMID- 9943540 TI - Atomic relaxations around vacancy clusters in molybdenum and their effects on trapped-positron lifetime. PMID- 9943542 TI - Jahn-Teller effect in the emission and excitation spectra of the Sb3+ ion in LPO4 (L=Sc,Lu,Y). PMID- 9943544 TI - Mossbauer effect used to study rare-earth oxides synthesized by a high-pressure method. PMID- 9943543 TI - Analysis of the net charge-compensation contribution in the fine structure of EPR defect centers: Cr3+, Fe3+, and Gd3+ in A2MX4-, AMX3-, and MX2-type crystals. PMID- 9943545 TI - Low-temperature ion-beam mixing in metals. PMID- 9943547 TI - X-ray-absorption fine-structure study of the A15 superconductors Nb3(Sn,Sb). PMID- 9943546 TI - Ginzburg-Landau parameters for an ErRh4B PMID- 9943548 TI - Superconductivity and structure in sputtered Nb-Ta multilayers. PMID- 9943549 TI - Critical currents in sputtered Nb-Ta multilayers. PMID- 9943550 TI - Resonantly enhanced quantum decay: A time-dependent Wentzel-Kramers-Brillouin approach. PMID- 9943552 TI - I-V characteristics of coupled ultrasmall-capacitance normal tunnel junctions. PMID- 9943551 TI - Consequences of resonant impurity scattering in anisotropic superconductors: Thermal and spin relaxation properties. PMID- 9943553 TI - Electronic behavior of oxygen-deficient YBa2Cu3O7- delta. PMID- 9943554 TI - Resistivity of nonmetallic La2-ySryCu1-xLixO4- delta single crystals and ceramics. PMID- 9943555 TI - Theory of the Hall coefficient of polycrystals: Application to a simple model for La2-xMxCuO4 (M=Sr, Ba). PMID- 9943556 TI - Valence bands and electron correlation in the high-Tc superconductors. PMID- 9943557 TI - Magnetoresistance as a probe of superconducting islands in La-Sr-Cu-O. PMID- 9943558 TI - Dependence of magnetic properties of pellets of nominal composition YBa2Cu PMID- 9943560 TI - Lattice-instability-enhanced high-temperature superconductivity for the perovskite-family oxides. PMID- 9943559 TI - Magnetic form factor of Cu in La2CuO PMID- 9943562 TI - Variational theory of superconductivity and application to the low-density electron gas. PMID- 9943561 TI - Homogeneous nucleation temperature of liquid 3He. PMID- 9943563 TI - Domain growth and topological defects in an Ising model with competing interactions. PMID- 9943564 TI - Monte Carlo study of growth in the two-dimensional spin-exchange kinetic Ising model. PMID- 9943565 TI - Mean-field model of the Verwey transition in magnetite. PMID- 9943566 TI - Concentration inhomogeneities in random magnets. I. Characterization using optical birefringence. PMID- 9943567 TI - Concentration inhomogeneities in random magnets. II. Effects on critical phenomena studies. PMID- 9943569 TI - Magnetic field dependence of the spin dynamics in the reentrant spin glass Fe70.4Al PMID- 9943568 TI - Molecular-dynamics simulation of the structural phase transition in Rb2CaCl4. PMID- 9943570 TI - Finite-temperature behavior of the Anderson lattice. PMID- 9943572 TI - Neutron-diffraction study of the magnetic ordering in EuAs3, Eu(As1-xPx)3, and beta -EuP3. PMID- 9943571 TI - Static critical behavior of annealed disordered alloys: Fe1-xVx. PMID- 9943574 TI - Paramagnetic form factors for cubic itinerant electron systems. PMID- 9943573 TI - First-principles study of the pressure-induced bcc-hcp transition in Ba. PMID- 9943575 TI - Random-field effects on the kinetics of a magnetic system with continuous symmetry. PMID- 9943577 TI - Direct numerical solution of the master-equation transport on disordered lattices via the Lanczos algorithm. PMID- 9943576 TI - Highly efficient algorithm for percolative transport studies in two dimensions. PMID- 9943578 TI - Effective force constant for a central-force random network. PMID- 9943579 TI - Fractal model for disordered magnets. PMID- 9943580 TI - Anderson localization and interactions in one-dimensional metals. PMID- 9943582 TI - Phase transitions in a quasi-two-dimensional XY random magnetic system. PMID- 9943581 TI - Coherent Kondo-lattice state and the crossover transitions in the Anderson lattice model. PMID- 9943583 TI - Formation of deep grooves in directional solidification. PMID- 9943584 TI - Integrable spin-1 Heisenberg chain with impurity. PMID- 9943585 TI - Band-theoretical study of magnetism in Sc2CuO PMID- 9943586 TI - Glass and phase transitions in (KBr)1-x(KCN)x. PMID- 9943587 TI - Electron-electron interaction from the pressure dependence of the Mossbauer isomer shift of metallic tin. PMID- 9943588 TI - Monte Carlo evidence of a phase transition in the two-dimensional step model. PMID- 9943589 TI - Magnetic properties of Cu2Zn1-xMnxGeS4: Antiferromagnetic interactions in the wurtz-stannite structure. PMID- 9943590 TI - Scaling and crossover in a fermion-boson mixture. PMID- 9943591 TI - Exact-eigenstates study of the disordered Hubbard model. PMID- 9943592 TI - Magnetic exchange in disordered metals. PMID- 9943594 TI - Dielectric relaxation thermodynamics: Comparison with experiment. PMID- 9943593 TI - Finite-temperature contributions to the specific heat of the electron-phonon system. PMID- 9943595 TI - Magnetic susceptibility of the Suzuki phase formed in NaCl:Mn2+ in the 0.07-4.2-K temperature range. PMID- 9943597 TI - Analytic solution of the block-cluster theory of site and bond percolation in arbitrary dimension. PMID- 9943596 TI - Orbital effects in magnetic dynamics of thulium iron garnets. PMID- 9943598 TI - Two-magnon Raman scattering in CdxMn1-xF2 mixed crystals. PMID- 9943599 TI - Fluctuation and bifurcation of the path described by generalized random walks. PMID- 9943600 TI - Anomalous logarithmic slow-dynamics behavior on hierarchical and random systems. PMID- 9943602 TI - Estimation of expectation values formed with Jastrow wave functions. PMID- 9943601 TI - Quasi-one-dimensional solid-liquid phase transition in compounds containing iodine trimers. PMID- 9943603 TI - Structure of icosahedral Al-(M1-xFex) alloys (M= Cr, Mn, or Fe). PMID- 9943604 TI - Cu-induced surface disruption of La1.85Sr0.15CuO4. PMID- 9943605 TI - Interface formation of semiconductors with high-Tc superconductors: Ge/La1.85Sr0.15CuO4. PMID- 9943606 TI - Observation of alignment of superconducting YBa2Cu3O7 particles in a magnetic field using neutron diffraction. PMID- 9943608 TI - Model for the role of oxygen defects in oxygen-defect superconductors. PMID- 9943607 TI - Size of Josephson junctions in Ba-Y-Cu-O compounds. PMID- 9943610 TI - Effect of pair hopping and magnitude of intra-atomic interaction on exchange mediated superconductivity. PMID- 9943609 TI - Crystal structure of the oxides BaCuGd2O PMID- 9943611 TI - Thermodynamic fluctuations in the high-Tc perovskite superconductors. PMID- 9943612 TI - Model for the order-disorder transition in YBa2Cu PMID- 9943613 TI - Evidence of low-energy tunneling excitations in the high-Tc superconductor YBa2Cu3O7-x. PMID- 9943614 TI - Time-dependent magnetization of a superconducting glass. PMID- 9943616 TI - Evidence for possible stable superconductivity at 500 K. PMID- 9943615 TI - Heat capacity of the high-temperature superconductor Ba2DyCu PMID- 9943618 TI - High-resolution x-ray-scattering study of charge-density-wave modulation in chromium. PMID- 9943617 TI - Meissner effect up to 300 K in microscopic regions of Y-Ba-Cu-O. PMID- 9943619 TI - Easily evaluated expressions for second and fourth moments of resonant absorption spectra for spin systems. PMID- 9943620 TI - Phase diagram for a random mixture of competing Ising anisotropies. PMID- 9943621 TI - Mooij correlation in disordered metals. PMID- 9943622 TI - Comment on "Time decay of the saturated remanent magnetization in a metallic spin glass" PMID- 9943623 TI - Reply to "Comment on 'Time decay of the saturated remanent magnetization in a metallic spin glass' " PMID- 9943624 TI - Gauge theory of high-temperature superconductors and strongly correlated Fermi systems. PMID- 9943625 TI - Backscattering of high-energy electrons from disordered media: Antienhancement due to the spin-orbit interaction. PMID- 9943626 TI - Observation of intense two-beam positron diffraction and the precise determination of the positron band gap in rare-gas crystals. PMID- 9943628 TI - Charged boson condensation in high-Tc superconductors. PMID- 9943629 TI - Electron-phonon interaction in Ba2YCu PMID- 9943627 TI - Magnetic ordering of Gd and Cu in superconducting and nonsuperconducting GdBa2Cu3O7- delta. PMID- 9943630 TI - High-Tc superconductor YBa2Cu3O7- delta studied by positron annihilation. PMID- 9943631 TI - X-ray and neutron diffracton study of La1Ba2Cu3O9- delta : Influence of the Cu-O structure on Tc. PMID- 9943632 TI - Thermodynamic fluctuations in the superconductor Y1Ba2Cu3O9-y: Evidence for two dimensional superconductivity. PMID- 9943633 TI - Millimeter-wave absorption in La-Ba-Cu-O and Y-Ba-Cu-O superconductors. PMID- 9943634 TI - Critical-magnetic-field anisotropy in single-crystal YBa2Cu3O7. PMID- 9943636 TI - Neutral fermion, charge-e boson excitations in the resonating-valence-bond state and superconductivity in La2CuO PMID- 9943635 TI - Magnetism and microstructure of YBa2Cu3O7-x superconductors produced by rapid solidification. PMID- 9943637 TI - High-Tc superconductivity at twin boundaries in a Landau-Ginzburg superconductor oxide model. PMID- 9943638 TI - Anisotropy in the near-edge absorption fine structure of YBa2Cu PMID- 9943639 TI - Determination of the magnetic field penetration depth in superconducting yttrium barium copper oxide: Deviations from the Bardeen-Cooper-Schrieffer laws. PMID- 9943640 TI - Magnetic screening by a thin superconducting surface layer. PMID- 9943641 TI - Destruction of global superconductivity in quench-condensed metal films. PMID- 9943642 TI - Universal criterion for the onset of superconductivity in granular films. PMID- 9943643 TI - Superconducting energy gap in MBa PMID- 9943644 TI - Ground state of the strong-coupling Hubbard Hamiltonian: A numerical diagonalization study. PMID- 9943645 TI - Quasi-two-dimensional behavior of the surface magnetization in a ferromagnet with softened surface exchange. PMID- 9943646 TI - Temperature-induced phase transitions in TlReO4: A Raman spectroscopic and x-ray diffraction study. PMID- 9943647 TI - Enhanced magnetoresistance of ultrathin (Au/Co)n multilayers with perpendicular anisotropy. PMID- 9943648 TI - Percolation and Cosserat elasticity: Exact results on a deterministic fractal. PMID- 9943649 TI - Scenario for the Vogel-Fulcher "law" PMID- 9943650 TI - Isotope effect and pressure dependence of the freezing temperature in proton glasses. PMID- 9943651 TI - Internal modes of a soliton. PMID- 9943652 TI - Dendritic solidification of krypton. PMID- 9943653 TI - ESR pumping experiments in spin-polarized atomic hydrogen. PMID- 9943654 TI - Structural characterization of a high-temperature, ionic conducting ceramic using perturbed angular correlation spectroscopy. PMID- 9943655 TI - EPR in dysprosium aluminum garnet at far-infrared frequencies. PMID- 9943656 TI - Model calculations of the static distribution of the electric-field-gradient tensor elements in substitutionally disordered Rb1-x(NH4)XH2PO4. PMID- 9943657 TI - Positron annihilation spectroscopy of methane monolayers adsorbed on graphite. PMID- 9943658 TI - Helicon-excited electron paramagnetic resonance in Hg1-xMnxSe. PMID- 9943659 TI - Evidence of g=2.013 defect centers in a-Si:H. PMID- 9943660 TI - Paramagnetic resonance hyperfine structure of hexachloroprotactinate(IV). PMID- 9943661 TI - Modulated adiabatic passage of oriented nuclei. I. The theory. PMID- 9943662 TI - Modulated adiabatic passage of oriented nuclei. II. Experimental results for CoFe alloys. PMID- 9943664 TI - Spectral dimensionality of random superconducting networks. PMID- 9943663 TI - Calculations of the shear modulus of a two-dimensional quantum solid. PMID- 9943665 TI - Dilute Bose gas in two dimensions. PMID- 9943666 TI - Tight-binding study of the electron-phonon interaction in bcc transition metals and alloys. PMID- 9943667 TI - Single-particle orbitals in liquid-helium drops. PMID- 9943669 TI - Magnetic anisotropy of the organic tetramethyltetraselenafulvalene salts (TMTSF)2X (X=ClO PMID- 9943668 TI - Iterative analytic continuation of the electron self-energy to the real axis. PMID- 9943670 TI - Inelastic scattering and pair breaking in anisotropic and isotropic superconductors. PMID- 9943671 TI - Solutions of the magnetic Eliashberg equations for heavy-fermion superconductors. PMID- 9943672 TI - Phonon velocity and atomic interaction in superfluid 4He. PMID- 9943674 TI - NMR in superfluid 3He in a confined geometry. PMID- 9943673 TI - Quasiparticle density of states for a spin-glass superconductor. PMID- 9943675 TI - Andreev reflection and geometrical resonance effects for a gradual variation of the pair potential near the normal-metal-superconductor interface. PMID- 9943676 TI - Fermion simulations in systems with negative weights. PMID- 9943677 TI - Superconductivity of divalent Chevrel phases at very high pressures. PMID- 9943678 TI - Possible determination of spin-orbit coupling in a heavy-fermion liquid by longitudinal sound velocity in the presence of a magnetic field. PMID- 9943679 TI - Exact and numerical study of the effective hopping of a particle interacting with a fermionic bath in one dimension. PMID- 9943681 TI - X-ray studies of high-temperature defects in concentrated isotopic helium solid solutions. PMID- 9943680 TI - Superconducting microcircuit and fluxoid quantization: A new quantum interferometer. PMID- 9943682 TI - Pairing in the two-dimensional Hubbard model: A Monte Carlo study. PMID- 9943683 TI - Superconducting transition temperatures of strongly coupled electron-boson systems: A self-consistent method for fluctuation from the Bardeen-Cooper Schrieffer limit to the bipolaronic limit. PMID- 9943684 TI - Theory of the superconducting proximity effect near the critical temperature. PMID- 9943685 TI - Green's-function theory of the superconducting proximity effect. PMID- 9943686 TI - Evidence for double valence fluctuation in metallic oxides of lead. PMID- 9943688 TI - Thermodynamic properties and superconducting transition temperature of vanadium doped with heavy impurities. PMID- 9943687 TI - X-ray study of the incommensurate modulation of the organic superconductor beta di PMID- 9943689 TI - Effects of Ni-to-Cu substitution on the properties of the high-Tcsuperconductor La1.85Sr0.15CuO4-y. PMID- 9943690 TI - X-ray photoemission, bremsstrahlung isochromat, Auger-electron, and optical spectroscopy studies of Y-Ba-Cu-O thin films. PMID- 9943691 TI - Raman scattering from high-Tc superconductors. PMID- 9943692 TI - Domain and crystal structure of superconducting Ba2YCu PMID- 9943693 TI - Evidence for holes on oxygen sites in the high-Tc superconductors La2-xSrx PMID- 9943694 TI - Photoemission studies of high-temperature superconductors YBa2Cu3O7- delta, GdBa2Cu3O7- delta, and EuBa2Cu3O7- delta. PMID- 9943695 TI - Phonons in YBa2Cu3O7- delta -type materials. PMID- 9943696 TI - Effect of HCl on the normal magnetic susceptibility of YBa2Cu3O7- delta. PMID- 9943697 TI - Superconductivity and crystal structure in the La-Ba-Cu-O system. PMID- 9943698 TI - Spin gap and symmetry breaking in CuO2 layers and other antiferromagnets. PMID- 9943699 TI - Exact solutions for Ising-model even-number correlations on planar lattices. PMID- 9943701 TI - Phase transitions in a compressible antiferromagnet with biquadratic coupling. PMID- 9943700 TI - Real-space renormalization-group study of fractal Ising models. PMID- 9943702 TI - Spin dynamics of EuO in the paramagnetic phase. PMID- 9943704 TI - Spin-disorder resistivity in the paramagnetic state of the heavy rare-earth dihydrides. PMID- 9943703 TI - Optical properties of aggregate clusters. PMID- 9943705 TI - Structure of asymmetric small-angle grain boundaries. PMID- 9943706 TI - Wetting transitions near Tc for marginal and supermarginal potential ranges. PMID- 9943707 TI - Surface critical behavior of tricritical systems. PMID- 9943708 TI - Growth of an orientationally ordered incommensurate potassium overlayer and its order-disorder transition on the Cu(111) surface. PMID- 9943709 TI - Theoretical spin-orbit coupling constants for 3d ions in crystals. PMID- 9943711 TI - Micromagnetic stability criterion for inhomogeneous magnetization distributions. PMID- 9943710 TI - Reentrant spin-glass-like behavior as a consequence of constrained dynamics of magnetic clusters: A case study of Fe1.4Ru1.6Si. PMID- 9943712 TI - Dilatometric study of critical behavior in CsPbCl3: Bicritical point at 41 degreesC. PMID- 9943714 TI - Spin-injection experiment. PMID- 9943713 TI - Coupling of electronic charge and spin at a ferromagnetic-paramagnetic metal interface. PMID- 9943715 TI - Evidence for nuclear-spin order in double-hcp praseodymium by neutron diffraction. PMID- 9943716 TI - Mean-field soft-spin Potts glass model: Statics and dynamics. PMID- 9943717 TI - Translational-rotational modes in noncentrosymmetric lattices: A lattice dynamical interpretation of the phenanthrene phase transition. PMID- 9943719 TI - Character of the alpha - beta phase transition in solid oxygen. PMID- 9943718 TI - Giant magnetic Gruneisen parameters in nearly ferromagnetic and heavy-fermion systems. PMID- 9943720 TI - Preservation of the free energy in a Migdal-Kadanoff approximation for the spin 1/2 anisotropic Heisenberg model. PMID- 9943722 TI - Theory of magnetic polarons in antiferromagnetic semiconductors. PMID- 9943721 TI - Quantum and thermal fluctuations of the anisotropic two-dimensional electron gas in a magnetic field. PMID- 9943724 TI - Susceptibility formalism for magnetic and quadrupolar interactions in hexagonal and tetragonal rare-earth compounds. PMID- 9943723 TI - Spin waves of two-sublattice Heisenberg ferrimagnets. PMID- 9943725 TI - Magnetic phase diagram of FeCl2 PMID- 9943726 TI - Critical behavior of the electrical resistance of very thin Cr films. PMID- 9943727 TI - Microscopic theory of spin-wave instabilities in parallel-pumped easy-plane ferromagnets. PMID- 9943728 TI - Three-body-exchange interaction in dense rare gases. PMID- 9943729 TI - Triple-point wetting of H2 films adsorbed on silver. PMID- 9943731 TI - Magnetic properties of a three-dimensional Ising crystal with zero-point entropy. PMID- 9943730 TI - Vectorized Monte Carlo simulation of large Ising models near the critical point. PMID- 9943732 TI - Optical studies of thermal cycling and hysteresis effects in elastic order disorder phase transformations. I. Pure alkali-metal cyanide crystals. PMID- 9943733 TI - Optical studies of thermal cycling and hysteresis effects in elastic order disorder phase transformations. II. Cyanide-diluted and mixed alkali-metal cyanide crystals. PMID- 9943734 TI - Thermodynamic behavior of random-field Ising ferromagnets. PMID- 9943735 TI - Derivation and generalization of the Suhl spin-wave instability relations. PMID- 9943736 TI - First-principles electronic-structure approach for phase diagrams of binary alloys. PMID- 9943737 TI - Determination of the crossover exponent in the random-field system MnxZn PMID- 9943738 TI - Computer simulation of the Heisenberg spin glass with Ruderman-Kittel-Kasuya Yosida-like coupling. PMID- 9943739 TI - Elastic fracture in random materials. PMID- 9943741 TI - New approach to localization: Quantum connectivity. PMID- 9943740 TI - Monte Carlo study of relaxation and diffusion in glassy systems. PMID- 9943742 TI - Susceptibility of Si:P across the metal-insulator transition. I. Diamagnetism. PMID- 9943744 TI - Combined band-structure and Kondo-collapse calculations of the gamma - alpha transition in cerium. PMID- 9943743 TI - Susceptibility of Si:P across the metal-insulator transition. II. Evidence for local moments in the metallic phase. PMID- 9943745 TI - Percolation of elastic networks under tension. PMID- 9943746 TI - Relaxation of charge-density-wave metastable states at T<4.2 K in NbSe3 as evidenced in the Shubnikov-de Haas oscillations. PMID- 9943747 TI - Heavy-fermion system: An exact many-body solution to a periodic-cluster Hubbard model. PMID- 9943749 TI - Magnetic moments and Pu form factor in PuFe2. PMID- 9943748 TI - Theoretical model for the hcp-bcc transition in Mg. PMID- 9943750 TI - Edge melting in two-dimensional solid films. PMID- 9943751 TI - Correlations in the one-dimensional almost-half-filled band Hubbard model in the large-U limit. PMID- 9943752 TI - Electronic structure and magnetic properties of 3d impurities in ferromagnetic metals. PMID- 9943754 TI - Numerical studies of Ising spin glasses in two, three, and four dimensions. PMID- 9943753 TI - Electronic structure and magnetic properties of 3d impurities in antiferromagnetic metals. PMID- 9943755 TI - Exact results for the site-dilute antiferromagnetic Ising model on finite triangular lattices. PMID- 9943756 TI - Experimental and theoretical study of the Raman spectrum in KTa1-xNbxO3 solid solutions. PMID- 9943757 TI - Current-dependent resistance of dilute switching networks. PMID- 9943758 TI - Pressure, substitution, and magnetic-field dependence of the valence phase transition in Yb0.4In PMID- 9943760 TI - Effects of quasiparticle screening on collective modes. II. Superconductors. PMID- 9943759 TI - Third-sound velocity measurements in layered mixture films. PMID- 9943762 TI - Observation of positional disorder in LiNaSO4 crystals by the electron spin resonance of the SO4- free radicals. PMID- 9943761 TI - Reentrant phase transitions in a quantum spin system with random fields. PMID- 9943763 TI - Ferromagnetism of composites with two interfaces. PMID- 9943764 TI - Transport coefficients of Lennard-Jones fluids: A molecular-dynamics and effective-hard-sphere treatment. PMID- 9943765 TI - Finite-size studies of the neutral-ionic transition in organic mixed-stack compounds. PMID- 9943766 TI - Dynamics of roughening and complete wetting. PMID- 9943767 TI - Porosity fluctuations, tortuosity fluctuations, and other types of fluctuations: Long-time tails and localization in porous media. PMID- 9943768 TI - Exact decimation approach to the Green's functions of the Fibonacci-chain quasicrystal. PMID- 9943769 TI - Two-dimensional Hubbard model with strong electron repulsion. PMID- 9943770 TI - Conformal field theory and the Au(110) (1 x 2)-to-(1 x 1) phase transition. PMID- 9943772 TI - Zero-temperature phase diagram of mixed-stack charge-transfer crystals. PMID- 9943771 TI - Effective-field renormalization-group study for the diluted Ising model. PMID- 9943774 TI - Spin-Peierls transition in Heisenberg chains with quantum spin. PMID- 9943773 TI - Fictitious spin-(1/2 operators and multitransition nuclear relaxation in solids: General theory. PMID- 9943775 TI - Model for a glassy adsorbate: Two-level systems and specific heat. PMID- 9943776 TI - Reanalysis of the condensate fraction for 4He from neutron scattering data. PMID- 9943777 TI - 13C solid-state NMR study of polyacenic materials. PMID- 9943778 TI - Angular dependence of Hc3 for an anisotropic superconductor with proximity effect. PMID- 9943779 TI - Structural phase transition and structure refinement of triclinic EuMo6S8 at 14 K studied by x-ray powder diffraction. PMID- 9943780 TI - Antiferromagnetic resonance in La2-x PMID- 9943781 TI - Effect of sulfur on the superconductivity of RBa PMID- 9943782 TI - Electronic structure of fluorinated YBa2Cu PMID- 9943784 TI - Thermal diffuse scattering of YBa2Cu3O7-x. PMID- 9943783 TI - Transport critical current in rare-earth-substituted superconductors RBa PMID- 9943785 TI - Decay of trapped flux in the high-Tc superconducting compound Y1Ba2Cu3O6.5+ delta. PMID- 9943787 TI - Photon-stimulated desorption of O2 from YBa2Cu PMID- 9943786 TI - Coherent twin boundaries in high-Tc superconducting oxides. PMID- 9943788 TI - Structure of the high-Tc superconductor Ba2YCu3Ox at 750 degreesC using neutron diffraction. PMID- 9943789 TI - Crossover of the spectral weight function: A new interpretation of some neutron scattering data. PMID- 9943790 TI - Size effect on the ferroelectric phase transition in PbTiO3 ultrafine particles. PMID- 9943791 TI - Strain-induced quadrupolar ordering of dipole-glass-like K1-xLixTaO3. PMID- 9943792 TI - Existence of a limiting distribution for disordered electronic conductors. PMID- 9943793 TI - Magnetic phase diagrams of diluted fcc antiferromagnets CopMg1-pO and EupSr1-pTe. PMID- 9943794 TI - Ferromagnetic resonance study of Ni79Mn PMID- 9943796 TI - Domain-wall pinning in the incommensurate phase of sodium nitrite. PMID- 9943795 TI - Temperature dependence of the phase diagram of Cl/Ag(100). PMID- 9943797 TI - Renormalization group and fractal cluster model of spin glasses. PMID- 9943798 TI - Field-dependent susceptibility of a paramagnet. PMID- 9943800 TI - Erratum: Critical behavior of coupled XY models PMID- 9943799 TI - Magnetic splitting of energy bands. PMID- 9943801 TI - Resonant-valence-bond state on a finite cluster. PMID- 9943803 TI - Superconductivity in a quasi-two-dimensional Bose gas. PMID- 9943802 TI - Proportionality of the Mn2+ g shift to the magnetization of the Ni2+ host lattice in the electron paramagnetic resonance of Mn2+-doped NiK2(SO4)2 PMID- 9943804 TI - Interlayer pair hopping: Superconductivity from the resonating-valence-bond state. PMID- 9943805 TI - Anomalous ultrasound propagation in the high-Tc superconductors: La1.8Sr0.2CuO4-y and YBa2Cu3O7- delta. PMID- 9943807 TI - High-resolution heat capacity of YBa2Cu3O6.9 over the superconducting transition region. PMID- 9943806 TI - Oxygen-vacancy-formation enthalpy in YBa2(Cu0.985Fe0.015)3O7- delta oxide superconductor. PMID- 9943809 TI - Electronic anisotropy in single-crystal La2CuO PMID- 9943808 TI - Ba2-xLaxYCu3O7+/- delta perovskite compounds: Crystal chemistry. PMID- 9943810 TI - Raman scattering from superconducting gap excitations in single-crystal YBa2Cu3O7 delta. PMID- 9943811 TI - Thermopower and the electron-phonon interaction in high-Tc superconductors. PMID- 9943812 TI - Electric-field-gradient-tensor study in YBa2Cu3O7- delta high-Tc superconductors. PMID- 9943813 TI - Role of bond lengths in the 90-K superconductor: A neutron powder-diffraction study of YBa2Cu PMID- 9943814 TI - Small oxygen isotope shift in YBa2Cu3O7. PMID- 9943815 TI - Microwave absorption studies of Y-Ba-Cu-O. PMID- 9943816 TI - Acoustic plasmons in a coupled array of sheets and chains and their role in YBa2Cu PMID- 9943817 TI - Superfluid density tensor in unconventional superconductors. PMID- 9943818 TI - Measurement of the effect of moderate dissipation on macroscopic quantum tunneling. PMID- 9943820 TI - Magnetic channel of the Kapitza resistance for a dilute 3He-4He solution at temperatures below 1 mK. PMID- 9943819 TI - Phase transition of dissipative Josephson arrays in a magnetic field. PMID- 9943821 TI - Lifshitz-Allen-Cahn domain-growth kinetics of Ising models with conserved density. PMID- 9943822 TI - Positional disorder in Josephson-junction arrays: Experiments and simulations. PMID- 9943823 TI - Ce valence mixing and strong 3d antiferromagnetism in CeMn2Si PMID- 9943825 TI - Monte Carlo simulations of the spin-(1/2 Heisenberg antiferromagnet on a square lattice. PMID- 9943824 TI - Wetting phenomena with long-range forces: Exact results for the solid-on-solid model with the 1/r substrate potential. PMID- 9943826 TI - First-principles study of ordering properties of substitutional alloys using the generalized perturbation method. PMID- 9943827 TI - Monte Carlo determination of the critical temperature for the two-dimensional XY model. PMID- 9943828 TI - CuCo: A new surface Kondo system. PMID- 9943829 TI - Dynamics in multiplicative processes. PMID- 9943830 TI - Rare-gas impurities in alkali metals: Relation to optical absorption. PMID- 9943831 TI - 3d transition metals on InP(110): A comparative study of reactive interface evolution. PMID- 9943832 TI - Detection of short- and long-range order in Cu-Pt alloys. PMID- 9943833 TI - Asymmetric x-ray diffraction by strained crystal wafers: 8 x 8-matrix dynamical theory. PMID- 9943834 TI - Defect production in Bi and dilute alloys irradiated by electrons. PMID- 9943835 TI - Persistent currents in small one-dimensional metal rings. PMID- 9943836 TI - Electronic Raman scattering from spherical particles. PMID- 9943838 TI - Effect of atomic order on the electrical resistivity of CoxFe PMID- 9943837 TI - Extended one-dimensional Hubbard model: A small-cluster approach. PMID- 9943839 TI - Influence of stoichiometry on defect-related phenomena in LiNbO3. PMID- 9943840 TI - Static and dynamic properties of the classical XY chain in a transverse magnetic field. PMID- 9943841 TI - Time evolution of a Bloch electron in a constant electric field. PMID- 9943842 TI - Optical-transition-matrix elements between localized electronic states in disordered one-dimensional systems. PMID- 9943843 TI - Surface barrier for electrons in metals. PMID- 9943844 TI - Relationship between defect energies and embedded-atom-method parameters. PMID- 9943845 TI - Inelastic processes in extended x-ray-absorption fine structure. PMID- 9943846 TI - Diagonalization of large matrices in pseudopotential band-structure calculations: Dual-space formalism. PMID- 9943848 TI - Effect of hole-induced shakedown in the Auger spectrum of lanthanum. PMID- 9943847 TI - Effects of various cover electrodes on the tunneling characteristics of Mg-MgO metal junctions. PMID- 9943850 TI - Hydrogen adsorption on Al(100). PMID- 9943849 TI - Cyclotron-resonance studies of electronic properties in ZnSe. PMID- 9943851 TI - Energetics of charged metallic particles: From atom to bulk solid. PMID- 9943852 TI - Two-terminal resistance of quantum Hall devices. PMID- 9943853 TI - Nonretarded hydrodynamic-model calculation of second-harmonic generation at a metal surface. PMID- 9943855 TI - Fluctuation properties of thermal solitons. PMID- 9943854 TI - Anomalous optical properties of liquid Hg. PMID- 9943856 TI - Structure of an icosahedral Al-Mn quasicrystal. PMID- 9943858 TI - Quasicrystals, crystalline phases, and multiple twins in rapidly solidified Al-Cr alloys. PMID- 9943857 TI - Surface properties and electronic structure of amorphous Zr75Ni25 and Zr75Ni25 hydride studied by photoemission. PMID- 9943859 TI - Optical study of electron backdonation and localized states in the metal-ammonia layers of K(NH3)xC24. PMID- 9943860 TI - Comparative study of Ag growth on (111) Au and Cu substrates. PMID- 9943861 TI - Quantum origin of half-flux oscillations in the magnetoresistance of metal cylinders. PMID- 9943862 TI - Extended x-ray bremsstrahlung isochromat of Pd. PMID- 9943863 TI - Local density of states in double-barrier resonant-tunneling structures. PMID- 9943864 TI - Electronic properties of a realistic model of amorphous silicon. PMID- 9943866 TI - Semiconductor alloy theory: Internal strain energy and bulk modulus. PMID- 9943865 TI - Spectroscopic determination of the band discontinuity in GaSb/AlSb multiple quantum-well structures. PMID- 9943867 TI - Theory of hot-electron energy loss in polar semiconductors: Role of plasmon phonon coupling. PMID- 9943869 TI - Determination of the atomic structure of the epitaxial CoSi2:Si(111) interface using high-resolution Rutherford backscattering. PMID- 9943868 TI - Structural correlations in silicon microclusters. PMID- 9943870 TI - Magnetic properties of EuTe-PbTe superlattices. PMID- 9943871 TI - Effects of the Hubbard interaction and electrostatic pinning in polyacetylene. PMID- 9943872 TI - Optically detected magnetic resonance of native defects in AlxGa PMID- 9943874 TI - Analysis of d-core excitons and interband transitions in synchrotron-radiation reflectance spectra of Cd1-xMnxTe and Cd1-xZnxTe within the energy range from 11 to 20 eV. PMID- 9943873 TI - Experimental exciton binding energies in GaAs/AlxGa PMID- 9943875 TI - Theory of electronic, vibrational, and superconducting properties of fcc silicon. PMID- 9943876 TI - Fractal geometry of electron orbits in random systems with strong magnetic field. PMID- 9943877 TI - Interaction of deuterium with defects in silicon studied by means of channeling. PMID- 9943878 TI - Analysis of photoassisted thermal recovery of metastable EL2 defects in GaAs. PMID- 9943879 TI - Phonon-drag effect in GaAs-AlxGa1-xAs heterostructures at very low temperatures. PMID- 9943880 TI - Raman scattering from GaSb/AlSb superlattices: Acoustic, optical, and interface vibrational modes. PMID- 9943881 TI - Resonant Raman study of the LO-phonon energy fluctuation in III-V alloy semiconductors. PMID- 9943882 TI - Conduction-band nonparabolicity in p-type quantum wells and Fourier determination of the hole wave functions by resonant Raman scattering. PMID- 9943884 TI - Cleavage faces of wurtzite CdS and CdSe: Surface relaxation and electronic structure. PMID- 9943883 TI - Theoretical possibilities for the Peierls instability in polyalkylsilene. PMID- 9943885 TI - Band structure of compensated n-i-p-i superlattices. PMID- 9943886 TI - Exchange effects on excitons in quantum wells. PMID- 9943887 TI - Transmutation-induced tritium in LiNbO3 single crystals. PMID- 9943889 TI - Amplitude mode in K2SeO PMID- 9943888 TI - Scattering of electromagnetic waves by rough dielectric surfaces. PMID- 9943890 TI - Hydrogen diffusion in the metallic glass a-Zr PMID- 9943891 TI - Origin of graphitic bands in graphite intercalation compounds. PMID- 9943892 TI - Nonlinear susceptibilities as a function of several complex angular-frequency variables. PMID- 9943893 TI - Modification of SiO through room-temperature plasma treatments, rapid thermal annealings, and laser irradiation in a nonoxidizing atmosphere. PMID- 9943894 TI - Pressure dependence of the optical-absorption edge of solid hydrogen in a diamond anvil cell. PMID- 9943895 TI - Elastic constants of alpha '-phase PdHx over the temperature range 4-300 K. PMID- 9943897 TI - Variational approximation of the electronic density profile at the surface of jellium. PMID- 9943896 TI - Multiple-scattering approach to the x-ray-absorption spectra of perovskite-type compounds. PMID- 9943898 TI - Twinning and symmetry. PMID- 9943900 TI - Structure and self-similarity of silica aerogels. PMID- 9943899 TI - Precursor molecular-oxygen state in the initial catalytic oxidation of the InP(110) surface modified by alkali metals. PMID- 9943902 TI - Refractive index of rare-gas liquids: First-principles calculation. PMID- 9943901 TI - Ab initio pseudopotential-local-density description of the structural properties of small carbon clusters. PMID- 9943904 TI - High-pressure study of alpha -quartz GeO2 using extended x-ray-absorption fine structure. PMID- 9943903 TI - Thermodynamic criterion for the analysis of point-defect data in solids. PMID- 9943905 TI - Optical absorption of the soliton lattice in polyacetylene reexamined. PMID- 9943906 TI - Surface phonon dispersion on Al(100). PMID- 9943907 TI - Resistance fluctuations in multiprobe microstructures: Length dependence and nonlocality. PMID- 9943908 TI - Experimental evidence for the existence of enhanced density of states and canonical spin-glass behavior in Al-Mn (-Si) quasicrystals. PMID- 9943910 TI - Dependence of tracer diffusion on atomic size in amorphous Ni-Zr. PMID- 9943909 TI - Soft-x-ray, heat-capacity, and transport measurements on icosahedral and crystalline alloys. PMID- 9943911 TI - Electronic anisotropy of nonlinear properties in the low-temperature sliding charge-density-wave state of K0.3MoO PMID- 9943912 TI - Thermoelectric fluctuations in multilead devices. PMID- 9943913 TI - Flux-cancellation effect on narrow-channel magnetoresistance fluctuations. PMID- 9943914 TI - One-dimensional subbands of narrow electron channels in gated AlxGa PMID- 9943915 TI - Effect of substitutional impurities on the low-temperature specific heat of (TaSe4)2I. PMID- 9943916 TI - "Forbidden" electronic- and nuclear-spin transitions in optically detected magnetic resonance spectra of deep complex defects in GaP. PMID- 9943917 TI - Growth mechanism for molecular-beam epitaxy of group-IV semiconductors. PMID- 9943918 TI - Thermal decomposition of a silicon-fluoride adlayer: Evidence for spatially inhomogeneous removal of a single monolayer of the silicon substrate. PMID- 9943919 TI - Neutron irradiation effects on the infrared absorption of the EL2 defect in GaAs: New interpretation for the intracenter transition. PMID- 9943920 TI - Scanning tunneling microscopy of 1T-TiSe2 and 1T-TiS2 at 77 and 4.2 K. PMID- 9943921 TI - Band-structure effects on the femtosecond energy relaxation of photoexcited electrons in AlxGa1-xAs/GaAs quantum wells. PMID- 9943922 TI - Quantitative analysis of EPR and electron-nuclear double resonance spectra of D centers in amorphous silicon: Dangling versus floating bonds. PMID- 9943923 TI - Structural dissimilarities between small II-VI compound clusters: MgO and CaO. PMID- 9943924 TI - Multiplet structure in the L2,3 x-ray-absorption spectra: A fingerprint for high- and low-spin Ni2+ compounds. PMID- 9943926 TI - Transmutation of the vicinal surface exponent due to gravity. PMID- 9943925 TI - Effect of Sm valence changes on photoemission spectra. PMID- 9943927 TI - Method for analyzing the ground state of intermediate-valence systems: Application to metallic SmS. PMID- 9943928 TI - Effect of scattering on the dynamic localization of a particle in a time dependent electric field. PMID- 9943929 TI - Origins of the universal binding-energy relation. PMID- 9943931 TI - Zone-center gap in the frequency spectrum of a commensurate monolayer. PMID- 9943930 TI - Effect of impurity interaction on the Anderson localization. PMID- 9943932 TI - Thermoelectric power in disordered electronic systems near the Anderson transition. PMID- 9943934 TI - Epitaxial growth of fcc Cr on Au(100). PMID- 9943933 TI - Inertial transient dynamics of sliding charge-density-wave systems. PMID- 9943935 TI - Conductivity of Kondo-type systems in the presence of crystal fields. PMID- 9943936 TI - Surface electronic structure: Embedded self-consistent calculations. PMID- 9943937 TI - Long-range correlations in disordered metals. PMID- 9943938 TI - Nonlocal corrections to Fresnel optics: Model calculations from first principles for flat jellium. PMID- 9943939 TI - Slow quenches of high-quality single crystals of platinum and palladium. PMID- 9943940 TI - Electronic-structure study of Ni81Cr15B4 metallic glass using photoemission spectroscopy. PMID- 9943941 TI - Shakeup in soft-x-ray emission. I. The low-energy tail. PMID- 9943942 TI - Shakeup in soft-x-ray emission. II. Plasmon satellites and x-ray photoemission spectroscopy. PMID- 9943943 TI - Atom scattering from surface Einstein modes. PMID- 9943944 TI - Magnetism, electronic structure, and Fermi surface of Ni3Al. PMID- 9943945 TI - Optics of multilayered conducting systems: Normal modes of periodic superlattices. PMID- 9943946 TI - Momentum density of vanadium: A reconstruction from two-dimensional positron annihilation data. PMID- 9943948 TI - Theory of transport properties of random alloys. PMID- 9943947 TI - Temperature dependence of energy and entropy of formation of self-interstitials in Cu. PMID- 9943949 TI - Nonlocal response of a small coated sphere. PMID- 9943950 TI - Resonance Raman spectrum of HfS2 and ZrS2. PMID- 9943951 TI - Hydrogen diffusion in bcc TiHx and Ti1-yVy PMID- 9943952 TI - Compton profile of palladium. PMID- 9943954 TI - Ordered-vacancy-compound semiconductors: Pseudocubic CdIn2Se4. PMID- 9943953 TI - Magnetic moments and x-ray photoelectron spectroscopy splittings in Fe 3s core levels of materials containing Fe. PMID- 9943955 TI - Inversion asymmetry and hole magnetooptics in zinc-blende semiconductors. PMID- 9943956 TI - Convenient expressions of diffusion coefficients for free electrons in gases in the presence of Ramsauer effects. PMID- 9943957 TI - Screening and exciton binding in multiple quantum wells. PMID- 9943958 TI - State and motion of hydrogen in crystalline silicon. PMID- 9943959 TI - Structural and electronic properties of epitaxial thin-layer SinGen superlattices. PMID- 9943961 TI - Chalcogens in germanium. PMID- 9943960 TI - Evaluation of total and partial structure factors, self-diffusion coefficients, and compressibilities of the cadmium-gallium melt. PMID- 9943962 TI - Schottky-barrier heights of transition-metal-silicide-silicon contacts studied by x-ray photoelectron spectroscopy measurements. PMID- 9943963 TI - Photo-Hall investigation of p-type HgTe-CdTe superlattices. PMID- 9943964 TI - Electron-hole scattering in GaAs quantum wells. PMID- 9943965 TI - Polaron Landau levels in InSb: A study of the influence of band nonparabolicity. PMID- 9943966 TI - Density of states for an electron in a correlated Gaussian random potential: Theory of the Urbach tail. PMID- 9943967 TI - Effects of an optical phonon on excitons in quantum wells. PMID- 9943968 TI - Thermodynamic properties of Si-Ge alloys. PMID- 9943969 TI - New empirical approach for the structure and energy of covalent systems. PMID- 9943970 TI - Behavior of electron gas in selectively doped GaAs/AlxGa1-xAs multiple-quantum well structures by Raman scattering. PMID- 9943971 TI - Concentration dependence of surface diffusion coefficients in clustering systems. PMID- 9943972 TI - Off-axis configuration of FA (Li) centers in RbCl. PMID- 9943973 TI - Microscopic origin of low-energy excitations in superionic glasses. PMID- 9943974 TI - Vibrational correlation function in ordered and disordered covalent solids. PMID- 9943975 TI - Infrared absorption and rotational dynamics of OH- and OD- defects in cesium halides. PMID- 9943976 TI - Dynamical theory of low-energy ionization of inert-gas atoms at surfaces. PMID- 9943977 TI - Temperature dependence of two-photon absorption linewidths of Eu2+ in CaF2. PMID- 9943979 TI - Dielectric relaxation of the aluminum-hole center in alpha -quartz: An example of phonon-assisted tunneling. PMID- 9943978 TI - Lattice vibrations in thin-film carbon: Electron-Rayleigh-wave interaction. PMID- 9943981 TI - Energy and thickness dependences of optical coefficients for polycrystalline metallic double-layer films. PMID- 9943980 TI - Dimensional crossover for a quasi-one-dimensional polaron. PMID- 9943982 TI - Phonons at the surface of the nearly-free-electron metal Al(111): Realization of an ideal surface. PMID- 9943983 TI - Perturbation theory for the electrical conductivity of quasiperiodic lattices. PMID- 9943984 TI - Magnetoresistance of amorphous MoxGe PMID- 9943985 TI - Limiting response time of double-barrier resonant tunneling structures. PMID- 9943986 TI - D- center in GaAs. PMID- 9943987 TI - Monte Carlo calculations of transport parameters of one-dimensional hot electrons in quantum-well wires. PMID- 9943988 TI - Bound magnetic polarons below T=1 K. PMID- 9943989 TI - Simple analytic model for heterojunction band offsets. PMID- 9943990 TI - Bonding at the K/Si(100) 2 x 1 interface: A surface extended x-ray-absorption fine-structure study. PMID- 9943991 TI - Exactly solvable one-dimensional model for impurity binding energies in quantum wells. PMID- 9943993 TI - Band structure of an effective-mass superlattice. PMID- 9943992 TI - Reduced dimensionality of hot-carrier relaxation in GaAs quantum wells. PMID- 9943994 TI - Chemical trends in Schottky barriers: Charge transfer into adsorbate-induced gap states and defects. PMID- 9943995 TI - Correlation between the light- and heavy-hole free-exciton fine structure in AlxGa1-xAs-GaAs multiple-quantum-well structures using photoluminescence excitation spectroscopy. PMID- 9943996 TI - Picosecond Raman studies of the optical phonons in the AlxGa1-xAs layers of GaAs AlxGa1-xAs multiple-quantum-well structures. PMID- 9943997 TI - Optical band gap of the filled tetrahedral semiconductor LiZnP. PMID- 9943998 TI - Multiple-scattering effects in surface extended x-ray absorption fine structure. PMID- 9943999 TI - Similarity between quantum Hall transport coefficients. PMID- 9944000 TI - Deviation from the classical 4:2 coordination in very thin SiO2 films grown on silicon. PMID- 9944001 TI - Theory of plasmons in lateral multiwire superlattices. PMID- 9944002 TI - Grazing-incidence x-ray scattering on the Cu3Au(111) phase transition. PMID- 9944003 TI - Inelastic neutron scattering from Sendust. PMID- 9944004 TI - Equilibrium negative-charge fractions in swift proton beams emerging from freshly evaporated metal films. PMID- 9944005 TI - Perturbed-angular-correlation spectroscopy: Structural anomalies in (Sr,Ca)(Zr3.95Hf0.05)P6O24 ceramics. PMID- 9944007 TI - Proton Knight shift in the organic conductor (fluoranthenyl)2AsF6. PMID- 9944006 TI - Many-body embedded-atom potential for describing the energy and angular distributions of Rh atoms desorbed from ion-bombarded Rh{111} PMID- 9944008 TI - Order parameter in incommensurate Rb2ZnCl4 studied by Mn2+ electron paramagnetic resonance. PMID- 9944009 TI - Relaxation and equilibrium of a spin system coupled to a radiation field. PMID- 9944010 TI - Electronic structure and associated properties of europium-activated strontium tetraborate phosphor. PMID- 9944011 TI - Theory of free-bound transitions in channeling radiation. PMID- 9944012 TI - Investigation of lattice-dynamical effects and hyperfine interactions in ZnO by 67Zn Mossbauer spectroscopy. PMID- 9944013 TI - Effect of a free surface in ion backscattering and sputtering. PMID- 9944014 TI - Electron-nuclear double resonance of titanium in silicon: 47Ti and 49Ti ENDOR. PMID- 9944015 TI - NMR line shapes and order-parameter determination in proton pseudo-spin-glasses. PMID- 9944016 TI - Influence of vanadium on the 57Fe-site spin and charge densities in cobalt vanadium alloys. PMID- 9944017 TI - Planar channeling in superlattices: Theory. PMID- 9944018 TI - Inelastic gas-surface scattering. II. Results. PMID- 9944019 TI - Energy-loss rate of a positron in a metal. PMID- 9944020 TI - Weak exchange interaction in cis-Cu(NH2CH2COO)2 PMID- 9944021 TI - Ultrasonic propagation above and below the martensitic transition in solid D2. PMID- 9944023 TI - Effects of the anomalous energy dispersion on the attenuation coefficient of first sound in liquid 4He. PMID- 9944022 TI - Sturm-Liouville description of sine-Gordon soliton dynamics. PMID- 9944024 TI - Experimental study of the growth of liquid 4He films on graphite. PMID- 9944026 TI - Small-radiation-amplitude dynamical voltage model of an irradiated, externally unbiased Josephson tunnel junction. PMID- 9944025 TI - Pairing in the two-dimensional Hubbard model: An exact diagonalization study. PMID- 9944028 TI - Coherent versus noncoherent Bloch oscillations in the presence of direct and alternating fields. PMID- 9944027 TI - Analytic calculation of ground-state properties of correlated fermions with the Gutzwiller wave function. PMID- 9944029 TI - New type of Cooper pairing in systems with strong electron-phonon interaction. PMID- 9944031 TI - Phonon dispersion relation in YBa2Cu PMID- 9944030 TI - Effect of oxygen pressure on the orthorhombic-tetragonal transition in the high temperature superconductor YBa2Cu PMID- 9944032 TI - Static and dynamic spin correlations in pure and doped La2CuO PMID- 9944033 TI - Resistive and magnetic studies of Nd1Ba PMID- 9944035 TI - Magnetic interaction between rare-earth moments in high-temperature superconductors RBa2Cu3O7-x. PMID- 9944034 TI - Structural and physical properties of the metal (M) substituted YBa2Cu3-xMxO7-y perovskite. PMID- 9944036 TI - Oxygen vacancies and antiferromagnetism in La2CuO PMID- 9944037 TI - Transport properties of the oxides Y1-xPrxBa2Cu3O7- delta (0 <= x <= 1): Effects of band filling and lattice distortion on superconductivity. PMID- 9944038 TI - Anisotropic normal-state transport properties predicted and analyzed for high-Tc oxide superconductors. PMID- 9944039 TI - Field-dependent microwave absorption in high-Tc superconductors. PMID- 9944041 TI - Reentrant softening in perovskitelike superconductors. PMID- 9944040 TI - Atomic substitutions in YBa2Cu PMID- 9944042 TI - Photoexcitations in La2CuO4: 2-eV energy gap and long-lived defect states. PMID- 9944043 TI - Effect of substitution of Bi, Ga, and Fe on the structure and superconducting transition of Y1Ba2Cu3O6.5+ delta. PMID- 9944044 TI - Oxygen-stoichiometry dependence of the electronic structure of YBa2Cu3O7- delta with delta (0< delta <0.7): Possibility of a highly correlated mixed-valent state. PMID- 9944045 TI - Linear muffin-tin-orbital atomic-sphere-approximation calculations of the electronic structure of YBa2Cu PMID- 9944047 TI - Surface melting and the surface phase diagram. PMID- 9944046 TI - Directed percolation in 3+1 dimensions. PMID- 9944048 TI - Solution of the one-dimensional Hubbard model for arbitrary electron density and large U. PMID- 9944050 TI - Phase transition in positionally disordered Josephson-junction arrays in a transverse magnetic field. PMID- 9944049 TI - Equations of state of the Potts ferromagnet in an anisotropic square lattice: Renormalization-group approach. PMID- 9944051 TI - Ground-state properties of field-induced spin-density waves in Bechgaard salts. PMID- 9944052 TI - Phase transitions of frustrated XY models on deformed square lattices. PMID- 9944053 TI - Thermodynamics of the one-dimensional diluted classical spin Heisenberg model with single-ion anisotropy. PMID- 9944054 TI - Random fields and orientational order in models with a continuous-energy minimum set in q space and in magnetic systems favoring an incommensurate order. PMID- 9944055 TI - Correlated-particles expansion through third order: The Lennard-Jones solid. PMID- 9944056 TI - Modified asymptotic approach to modeling a dilute-binary-alloy solidification front. PMID- 9944057 TI - Scaling theory of tunneling diffusion of a heavy particle interacting with phonons. PMID- 9944058 TI - Roughening and facet formation in the presence of subharmonic potentials. PMID- 9944059 TI - Electrical breakdown in a fuse network with random, continuously distributed breaking strengths. PMID- 9944060 TI - Cayley-tree Ising model with antiferromagnetic nearest-neighbor and ferromagnetic equivalent-neighbor interactions. PMID- 9944061 TI - Charge and spin fluctuations in metals. PMID- 9944062 TI - Ising spin glass at zero temperature on the Bethe lattice. PMID- 9944064 TI - Coulomb correlation effects in the quasiparticle band structure of ferromagnetic rare-earth insulators. PMID- 9944063 TI - Anomalous-diffraction studies of modulated structures. PMID- 9944065 TI - Heisenberg-to-Ising crossover in a random-field model with uniaxial anisotropy. PMID- 9944066 TI - Magneto-optical properties of the competing-anisotropy model system Fe1-xCoxCl2. II. Faraday rotation. PMID- 9944068 TI - Intensity of nuclear multiphoton transitions for 57Fe in thin ferromagnetic films under static and radio-frequency magnetic fields. PMID- 9944067 TI - Lattice-dynamical calculations of N-methyl-N-ethyl-morpholinium bis(tetracyanoquinodimethane) above and below the spin-Peierls transition temperature. PMID- 9944070 TI - Nonlocal Landau free-energy functional: Application to the magnetic phase transition in CsNiF3. PMID- 9944069 TI - Eu2Ni3Si5: A new valence-fluctuation system. PMID- 9944071 TI - Effective-medium approximation for a percolation network: The structure factor and the Ioffe-Regel criterion. PMID- 9944072 TI - Evidence for martensiticlike phase transformations in metallic glasses. PMID- 9944074 TI - Monte Carlo study of the Coulomb-gas representation of frustrated XY models. PMID- 9944073 TI - Nonlinear friction in a homogenous electron gas: Exact results. PMID- 9944075 TI - Monte Carlo renormalization-group study of Ising spin glasses. PMID- 9944076 TI - Scattering by rough surfaces. PMID- 9944077 TI - Small-angle x-ray scattering study of phase separation in amorphous alloys during heating with use of synchrotron radiation. PMID- 9944078 TI - Low-temperature expansions for an Ising model on a hexagonal-close-packed lattice with competing interactions. PMID- 9944079 TI - Magnetic and thermodynamical properties of the simple-cubic Hubbard model. PMID- 9944080 TI - Magnetic properties of amorphous mixed alloys with low dimensionalities. PMID- 9944082 TI - Phase transitions in finite systems with O(n) symmetry: Magnetization and susceptibility in the presence of an external field. PMID- 9944081 TI - Equilibrium shape of NaCl crystals: A first-principles calculation. PMID- 9944083 TI - Mean-field hopping solution in the Anderson-Hubbard model. PMID- 9944084 TI - Annealing effects on the sound velocity and internal friction in the superconducting and normal states of the Cu30Zr PMID- 9944086 TI - Flux quantization with a high-Tc model. PMID- 9944085 TI - Criticality of the bond-diluted Ising ferromagnet in a semi-infinite simple-cubic lattice. PMID- 9944087 TI - Mossbauer study of CsFeBr3. PMID- 9944088 TI - New approach to characterizing the high-temperature superconducting transition. PMID- 9944089 TI - Tunneling spectroscopy of YBa2Cu3O6.5+x and Y0.95Al0.05Ba2Cu3O6.5+x with use of a scanning-tunneling microscope. PMID- 9944090 TI - Melt-textured growth of polycrystalline YBa2Cu3O7- delta with high transport Jc at 77 K. PMID- 9944091 TI - Layer plasmons and high-Tc superconductivity. PMID- 9944092 TI - Orthorhombic (II) superstructure phase in oxygen-deficient YBa2Cu3O7- delta prepared by quenching. PMID- 9944093 TI - Upper critical field, fluctuation conductivity, and dimensionality of YBa2Cu3O7 x. PMID- 9944095 TI - Compressibility of the high-Tc superconductor La1.7Ba PMID- 9944094 TI - Giant defect-enhanced electron-phonon interactions in YBa2Cu PMID- 9944096 TI - Electronic structure of high-temperature superconductors. PMID- 9944098 TI - Gd interactions in (Ce,Gd)Al3. PMID- 9944097 TI - Study of Hamiltonians with long-range interactions: The XY model. PMID- 9944099 TI - Constraints on high-temperature series expansions for spin correlations in the square Ising model. PMID- 9944101 TI - Energy flow during the soliton-antisoliton interaction in extended Klein-Gordon systems. PMID- 9944100 TI - Conformal invariance and critical behavior of a quantum Hamiltonian with three spin coupling in a longitudinal field. PMID- 9944102 TI - Comment on the conductivity exponent in continuum percolation. PMID- 9944103 TI - Reply to "Comment on the conductivity exponent in continuum percolation" PMID- 9944105 TI - Erratum: Thermal conductivity of 4He I near T lambda from vapor pressure to 28 bars: Comparison of experiment and theory PMID- 9944104 TI - Comment on "Self-trapping on a dimer: Time-dependent solutions of a discrete nonlinear Schrodinger equation" PMID- 9944106 TI - Anomalous vibrations of hydrogen isotopes in beta -phase vanadium hydride. PMID- 9944108 TI - Power-law fading of the frustration effect in a periodic rectangular superconducting network with increasing aspect ratio. PMID- 9944107 TI - Hot-electron diffusion lengths in the rare-gas solids. PMID- 9944110 TI - Quantum displacement-charge transitions in two-dimensional granular superconductors. PMID- 9944109 TI - Observation of phase fluctuations and electron-electron scattering in weakly disordered superconducting aluminum films. PMID- 9944111 TI - Schottky anomaly in the heat capacity of the high-Tc superconductor YBa2Cu PMID- 9944112 TI - X-ray-scattering study of finite-range order in Ba2YCu3O6.7. PMID- 9944113 TI - Oxygen defect in YBa2Cu PMID- 9944114 TI - Out-of-plane conductivity in single-crystal YBa2Cu PMID- 9944115 TI - Successive magnetic phase transitions in tetragonal YBa2Cu PMID- 9944117 TI - Ginzburg-Landau theory of resonating valence bonds and its U(1) phase dynamics. PMID- 9944116 TI - Initial stages of degradation of superconductor surfaces: O2, H2O, CO2, and CO chemisorption on La2-xSrxCuO4. PMID- 9944118 TI - Cu nuclear magnetic resonance of aligned single crystals of YBa2Cu3O7- delta. PMID- 9944120 TI - Angle-resolved photoemission studies of single-crystal YBa2Cu PMID- 9944119 TI - Electronic structure of high-Tc superconductors from core-level spectroscopies. PMID- 9944121 TI - Upper critical field and resistivity of single-crystal EuBa2Cu PMID- 9944122 TI - Joint x-ray and neutron refinement of the structure of superconducting YBa2Cu PMID- 9944123 TI - Observations on the thermopower of the high-Tc superconductors. PMID- 9944125 TI - Frequencies, eigenvectors, and single-crystal selection rules of k=0 phonons in YBa2Cu3O7- delta : Theory and experiment. PMID- 9944124 TI - 57Fe Mossbauer study of the superconductor YBa2(FexCu1-x)3Oy. PMID- 9944126 TI - Surface conduction and length scales in porous media. PMID- 9944127 TI - Hole propagation in correlated spin systems. PMID- 9944128 TI - Phase transition induced by a magnetic field in NbSe3. PMID- 9944130 TI - Optical and transmission-electron-microscopy characterization of metal precipitates in doped thermochemically reduced magnesium oxide. PMID- 9944129 TI - Magnetic transitions in bcc vanadium, chromium, manganese, and iron. PMID- 9944131 TI - Optical properties of submicrometer-size silver needles. PMID- 9944132 TI - Synchrotron-radiation photoemission studies of Cu/InSb(110) interface evolution and modification by Al interlayers. PMID- 9944133 TI - Interface-response theory of electromagnetism in dielectric superlattices. PMID- 9944134 TI - Electron density at the Ag(110) surface studied by He diffraction. PMID- 9944135 TI - Absence of phonon-induced localization for the free optical polaron and the corresponding Wannier exciton-phonon system. PMID- 9944136 TI - 2 pi resonance features in the electronic spectra of chemisorbed CO. PMID- 9944138 TI - Nonlinear optical response of superlattices: Multistability and soliton trains. PMID- 9944137 TI - Photoelectron diffraction on clean W(110) surface and bulk 4f core levels. PMID- 9944139 TI - Interpretation of photoemission and bremsstrahlung isochromat spectra of uranium compounds. PMID- 9944140 TI - Angle-resolved photoemission study of a thin FeO(111) layer formed on Fe(110). PMID- 9944141 TI - Structural basis of multistationary quantum systems. I. Effective single-particle dynamics. PMID- 9944142 TI - Structural basis of multistationary quantum systems. II. Effective few-particle dynamics. PMID- 9944143 TI - Evolution of the electronic structure of the Cr/Au(001) interface. PMID- 9944144 TI - Structural and valence properties of the amorphous-metallic high-pressure phase of SnI4. PMID- 9944145 TI - Symmetry breaking in the molecular-dynamics method for ab initio total-energy calculations. PMID- 9944147 TI - Inverse photoemission from Ag(111) calculated by a multiple-scattering method. PMID- 9944146 TI - Scale equivalence of quasicrystallographic space groups. PMID- 9944148 TI - Spin and orbital contributions to the dynamical structure factors of paramagnetic transition metals. PMID- 9944149 TI - Quantum-mechanical stress and a generalized virial theorem for clusters and solids. PMID- 9944150 TI - Interpolation formula for the energy of a two-dimensional electron gas in the lowest Landau level. PMID- 9944152 TI - Electronic structure of the Ge(111)-c(2 x 8) surface. PMID- 9944151 TI - Scattering of electromagnetic beams from rough surfaces. PMID- 9944154 TI - Electron-hole scattering and the negative absolute mobility of electrons in a semiconductor quantum well. PMID- 9944153 TI - Stark effect in strongly coupled quantum wells. PMID- 9944155 TI - Bond-orbital models for superlattices. PMID- 9944156 TI - Negative minority-electron mobility in a nonequilibrium electron-hole plasma. PMID- 9944157 TI - Diagonal and off-diagonal disorder in doped quantum wells. PMID- 9944159 TI - Energies of substitution and solution in semiconductors. PMID- 9944158 TI - Hydrogen desorption kinetics from monohydride and dihydride species on silicon surfaces. PMID- 9944160 TI - Critical behavior of the zero-temperature conductivity in compensated silicon, Si:(P,B). PMID- 9944161 TI - Properties of trans-polyacetylene with sp3 defects. PMID- 9944163 TI - One-dimensional hopping mobility in disordered layered semiconductors: Applications to InSe. PMID- 9944162 TI - Defect formation in H implantation of crystalline Si. PMID- 9944165 TI - Universal behavior near the band edges for disordered systems: Numerical and coherent-potential-approximation studies. PMID- 9944164 TI - Surface structure of As-stabilized GaAs(001): 2 x 4, c(2 x 8), and domain structures. PMID- 9944166 TI - Evidence for large lattice relaxation at the DX center in Si-doped AlxGa PMID- 9944167 TI - Initial stages of reaction and barrier heights in nickel silicide interface growth. PMID- 9944168 TI - Vibrational spectroscopy of acceptor-hydrogen complexes in silicon: Evidence for low-frequency excitations. PMID- 9944169 TI - Temperature-dependent multisubband polarizability and dielectric function for the two-dimensional electron gas in heterojunctions. PMID- 9944170 TI - First-principles calculation of highly asymmetric structure in scanning-tunneling microscopy images of graphite. PMID- 9944171 TI - Electronic states of doped semiconductor superlattices in magnetic and electric fields. PMID- 9944173 TI - Precise quasiparticle energies and Hartree-Fock bands of semiconductors and insulators. PMID- 9944172 TI - Anomalous telegraph noise in small-area silicon metal-oxide-semiconductor field effect transistors. PMID- 9944175 TI - Optical phonons in mixed-layer crystals of the series SnSxSe2-x (0 <= x <= 2). PMID- 9944176 TI - Double transitions in the Raman spectrum of the fundamental band of solid parahydrogen. PMID- 9944174 TI - Effects of oxidation on surface band-gap states in a-Si:H. PMID- 9944178 TI - Electronic structure of an oxygen vacancy in lithium niobate. PMID- 9944177 TI - Photoemission study of SiOx (0 <= x <= 2) alloys. PMID- 9944180 TI - Thermal conductivity in amorphous solids at temperatures below 1 K. PMID- 9944179 TI - Usefulness of the special q points in the study of rare-gas monolayers. PMID- 9944181 TI - Electronic and vibrational absorption and emission properties of F-center-OH- defect pairs in cesium halides. PMID- 9944183 TI - Neutron scattering study of phonon-libron coupling in potassium-ammonia intercalated graphite. PMID- 9944182 TI - Electron-energy-loss study of the TiO2(110) surface. PMID- 9944184 TI - Adsorption of potassium on the ideal Si(111) surface. PMID- 9944186 TI - Defects on Ne-bubble surfaces in Mo. PMID- 9944185 TI - Size effects on the vacancy-formation energy of small sodium clusters in the jellium model. PMID- 9944187 TI - Raman scattering from plasma excitations in a conducting double layer. PMID- 9944188 TI - Ultrasonic study of the martensitic phase transformation in sodium. PMID- 9944190 TI - Experimental study of nonlinear conductance in small metallic samples. PMID- 9944189 TI - Interface response theory of phonons in N-layer superlattices. PMID- 9944191 TI - X-ray and Raman scattering measurements in finite, pseudomorphically strained, Fibonacci lattices. PMID- 9944192 TI - Correlation between geometric and elastic parameters in structural modification of interfacial superstructures. PMID- 9944193 TI - Evidence for the intrinsic nature of light-induced defects in undoped a-Si:H. PMID- 9944194 TI - Search for narrow-band noise under pulsed electric fields in the nonlinear conduction regime of tetrathiafulvalene tetracyanoquinodimethane. PMID- 9944195 TI - Real-time dielectric relaxation in glassy polyvinylacetate. PMID- 9944196 TI - Erratum: Correlation correction to the Hartree-Fock total energy of solids PMID- 9944198 TI - X-ray photoemission study of delta -Pu stabilized by 1 wt. % Ga: Electronic structure and sputter-induced surface phase transformation. PMID- 9944197 TI - Quantitative experimental test for the theoretical gap energies in the fractional quantum Hall effect. PMID- 9944199 TI - Quasicrystal structure of rapidly solidified Ti-Ni-based alloys. PMID- 9944200 TI - Environmentally specific mechanical properties: Beyond atomic parameters. PMID- 9944201 TI - Electronic contributions to the hydrogen-induced reconstruction of W(110). PMID- 9944202 TI - Structure of icosahedral clusters in cubic Al5.6Li PMID- 9944204 TI - Enhanced magnetic surface scattering of weakly localized electrons. PMID- 9944203 TI - High-pressure structural phase transitions in tellurium. PMID- 9944205 TI - Defect states at floating and dangling bonds in amorphous Si. PMID- 9944206 TI - Optical spectroscopy of two-dimensional electrons in GaAs-AlxGa1-xAs single heterojunctions. PMID- 9944208 TI - Early-stage formation of metal-semiconductor interfaces. PMID- 9944207 TI - Atomic structure of one monolayer of GaAs on Si(111). PMID- 9944209 TI - Band-edge deformation potentials in a tight-binding framework. PMID- 9944211 TI - Excitonic optical nonlinearity of quantum-well structures in a static electric field. PMID- 9944210 TI - Breathing-mode lattice relaxation associated with the vacancy and phosphorous vacancy-pair (E-center) defect in silicon. PMID- 9944212 TI - Acoustic-phonon scattering in modulation-doped heterostructures. PMID- 9944214 TI - Occurrence of impurity bands in quantum-well wires. PMID- 9944213 TI - Four-terminal magnetoresistance of a two-dimensional electron-gas constriction in the ballistic regime. PMID- 9944215 TI - Sensitivity of the conductance to impurity configuration in the clean limit. PMID- 9944216 TI - Absorption spectra and energy levels of Gd3+, Nd3+, and Cr3+ in the garnet Gd3Sc2Ga3O12. PMID- 9944217 TI - Properties of amorphous Zr3RhHx prepared from glassy and crystalline alloys. PMID- 9944218 TI - Local-field correction in jellium. PMID- 9944219 TI - Electronic structure of the icosahedral and other phases of aluminum-manganese alloys studied by soft-x-ray emission spectroscopy. PMID- 9944220 TI - Nonequilibrium c(2 x 2) island formation during chemisorption: Scaling of spatial correlations and diffracted intensity. PMID- 9944222 TI - Failure of Migdal's approximation in electron transport. PMID- 9944221 TI - New method for evaluating the dc effective conductivities of composites with periodic structure. PMID- 9944224 TI - Calculation of the electron momentum density in Zr and ZrH2. PMID- 9944223 TI - Resistance oscillations and crossover in ultrathin gold films. PMID- 9944225 TI - Optical properties of thallium films studied with synchrotron radiation. PMID- 9944226 TI - Theory of interlayer spacing in ternary graphite intercalation compounds. PMID- 9944227 TI - Unoccupied electronic structure of Au and Ag on Ge(111). PMID- 9944228 TI - Absence of phase transitions in Holstein systems. PMID- 9944229 TI - Phase vortices in charge-density-wave conductors. PMID- 9944231 TI - Electrical transport properties of thin epitaxially grown iron films. PMID- 9944230 TI - Electronic structure of matter at high compression: Isostructural transitions and approach of the Fermi-gas limit. PMID- 9944232 TI - Work function and image-plane position of metal surfaces. PMID- 9944233 TI - Many-body small-cluster theory of bcc Fe, Co, and the Fe-Co alloy. PMID- 9944234 TI - High-pressure phases of uranium monophosphide studied by synchrotron x-ray diffraction. PMID- 9944235 TI - Nonlinear susceptibilities of granular matter. PMID- 9944237 TI - Electronic and structural properties of MgH2. PMID- 9944236 TI - Decay of "autoionizing" core-hole states in adsorbed CO molecules. PMID- 9944238 TI - Electronic transport properties of thin potassium wires below 1 K. I. Derivative of electrical resistivity, d rho /dT. PMID- 9944240 TI - Resonant tunneling through GaAs quantum-well energy levels confined by AlxGa1-xAs Gamma - and X-point barriers. PMID- 9944239 TI - Electronic transport properties of thin potassium wires below 1 K. II. Thermoelectric ratio G. PMID- 9944241 TI - Excitons in quantum boxes: Correlation effects and quantum confinement. PMID- 9944242 TI - Thermal properties of a tetrahedrally bonded amorphous solid: CdGeAs2. PMID- 9944243 TI - Auger recombination in direct-gap semiconductors: Effect of anisotropy and warping. PMID- 9944245 TI - Spin-forbidden Delta ms=2 transitions in the optically detected magnetic resonance spectra of excitons bound at complex neutral defects in GaP. PMID- 9944244 TI - Excitonic molecules in ZnSe quantum wells. PMID- 9944246 TI - Excitons near interfaces of polar crystals. PMID- 9944247 TI - All-electron local-density theory of covalently bonded material adsorbed on metallic substrate: p(1 x 1) Si monolayer on W(001). PMID- 9944248 TI - Domain structure and impurity length-scale effects in switching charge-density wave conductors. PMID- 9944250 TI - Optical investigation of a-Si:H/a-SiNx:H superlattices. PMID- 9944249 TI - Angular dependence of phonon transmission through a Fibonacci superlattice. PMID- 9944252 TI - Indirect exchange interaction in the zero-gap semiconductor Hg1-xMnxTe. PMID- 9944251 TI - Hydrogenation of semiconductor surfaces: Si and Ge (111). PMID- 9944253 TI - Effects of uniaxial stress on hole subbands in semiconductor quantum wells. I. Theory. PMID- 9944254 TI - Effects of uniaxial stress on hole subbands in semiconductor quantum wells. II. Numerical results. PMID- 9944255 TI - Experimental study of the dc conductivity mechanisms in amorphous SixSn1-x alloys. PMID- 9944257 TI - Fluctuations of the hot-carrier state-occupancy function in homogeneous semiconductors. PMID- 9944256 TI - Electron-diffraction study of chemical ordering in glow-discharge a-Si1-xCx:H. PMID- 9944258 TI - Dispersion theory for the two-dimensional polaron. PMID- 9944259 TI - Influence of the electron-electron interaction on the cyclotron resonance half width in bulk CdTe. PMID- 9944260 TI - Anisotropy of optical phonons and interface modes in GaAs-AlAs superlattices. PMID- 9944262 TI - Ab initio study of the interaction of polyoxymethylene with polyoxymethylene, ammonium perchlorate, and the aluminum (100) surface. PMID- 9944261 TI - Minigaps and high-density activated transport in n-channel Si inversion layers. PMID- 9944263 TI - Effects of nonequilibrium phonons on the energy relaxation and recombination lifetime of photogenerated carriers in undoped GaAs quantum wells. PMID- 9944264 TI - Disorder effects in alloy superlattices. PMID- 9944265 TI - Shallow donors in magnetic fields in zinc-blende semiconductors. III. Subtleties of the conduction band and spin doublets in GaAs. PMID- 9944266 TI - Electron-nuclear double resonance of interstitial positively charged iron in silicon. PMID- 9944267 TI - Role of metal d states in II-VI semiconductors. PMID- 9944269 TI - Dynamics of photoexcitations in cis-polyacetylene. PMID- 9944268 TI - Defect centers and changes in the electrical characteristics of Al/n-type Si Schottky diodes induced by hydrogen-ion implantations. PMID- 9944271 TI - Asymmetrical relaxation of simple E' centers in silicon dioxide isomorphs. PMID- 9944270 TI - Self-consistent energy-functional perturbation theory for an electron gas in a cylindrical quantum well. PMID- 9944272 TI - Computer studies of system densities of states and of correlations in the excitation spectra of interacting electrons in disordered insulators. PMID- 9944273 TI - Effective bond-stretching force constants in chalcopyrite CuGaSe2 by temperature dependence of extended x-ray-absorption fine-structure spectra. PMID- 9944274 TI - Dynamics of the spin-glass freezing in Cd0.6Mn0.4Te. PMID- 9944276 TI - Reflectivity of bismuth germanate. PMID- 9944275 TI - Electronic properties of stage-3 SbCl5-intercalated graphite. PMID- 9944277 TI - Tip electronic structure in scanning tunneling microscopy. PMID- 9944278 TI - Heat-transport Ward identity and effective Landau Fermi-liquid parameters in disordered systems. PMID- 9944279 TI - Calorimetric observations of amorphous and crystalline Ni-Zr alloy formation by solid-state reaction. PMID- 9944280 TI - NMR study of Li in Al-Li-Cu icosahedral alloys. PMID- 9944281 TI - Backscattering of light from a random medium: Application to the critical region. PMID- 9944282 TI - Energy dependence of the electron-phonon coupling in a thin-layer GaAs/AlAs superlattice. PMID- 9944283 TI - Electronic states of semiconductor-metal-semiconductor quantum-well structures. PMID- 9944285 TI - Quasielastic light scattering in (KBr)1-x(KCN)x. PMID- 9944284 TI - Theoretical estimation of static charge fluctuation in amorphous silicon. PMID- 9944286 TI - Local field in glass probed by laser-induced fluorescence-line narrowing in Ca(PO3)2:Eu3+ PMID- 9944287 TI - Observation of ( omega, omega ) backward-wave phonon echoes in quartz crystals after neutron irradiation, electrodiffusion, and annealing. PMID- 9944288 TI - Phase-shift problem in the study of the c(2 x 2)S/Ni(100) surface by surface extended x-ray-absorption fine-structure spectroscopy. PMID- 9944290 TI - Electric field dependence of the exciton binding energy in GaAs/AlxGa1-xAs quantum wells. PMID- 9944289 TI - Comment on "Ring exchange and the fractional quantum Hall effect" PMID- 9944291 TI - k gaps for surface polaritons on gratings. PMID- 9944292 TI - Isotopic effect in the formation of copper-ion clusters by neutral-argon-atom bombardment. PMID- 9944293 TI - Photoelectron diffraction study of Si(001)2 x 1-K surface: Existence of a potassium double layer. PMID- 9944295 TI - Many-electron theory of charge transfer in ion-surface scattering. PMID- 9944294 TI - In-plane quasi-isotropic organic superconductor di PMID- 9944296 TI - Preparation, structure, and spectroscopic properties of Nd3+:{La1-xLux}3 PMID- 9944297 TI - Time-differential perturbed-angular-correlation study of hyperfine interactions at 111Cd in a Li0.5Fe PMID- 9944298 TI - Relationship between microstructures and optoelectronic properties of Ag-O-Cs photoemitting surfaces: The S-1 photocathode. PMID- 9944299 TI - ESR study of the hydrogen-potassium-graphite ternary intercalation compounds. PMID- 9944300 TI - Positron annihilation study of deformed silver. PMID- 9944301 TI - Excited-state-absorption and laser parameters of V2+ in MgF2 and KMgF3. PMID- 9944302 TI - Excited-state absorption of Ni2+ in MgF2 and MgO. PMID- 9944304 TI - Polarization of protons by the spin-refrigerator mechanism in yttrium ethyl sulfate. PMID- 9944303 TI - Macroscopic description of fast heavy-ion-induced desorption yields. PMID- 9944306 TI - Electron paramagnetic resonance in Cd1-xMnxS, Cd1-xMnxSe, and Cd1-xMnxTe. PMID- 9944305 TI - Nuclear spin-lattice relaxation of dilute spins in semiconducting diamond. PMID- 9944307 TI - Neutron-scattering and Monte Carlo study of short-range order and atomic interaction in Ni0.89Cr PMID- 9944309 TI - Spin-Hamiltonian parameters of 6S-state ions. PMID- 9944308 TI - Stopping powers and energy loss of 3-22-MeV 12C ions in Havar, nickel, Kapton, and Mylar. PMID- 9944310 TI - Z3 correction to the stopping power of ions in an electron gas. PMID- 9944311 TI - Rate theory of dislocation motion: Thermal activation and inertial effects. PMID- 9944312 TI - Intermediate statistics for vortices in superfluid films. PMID- 9944313 TI - Nonuniversal critical behavior in the critical current of superconducting composites. PMID- 9944314 TI - Cosmiclike domain walls in superfluid 3He-B: Instantons and diabolical points in (k,r) space. PMID- 9944316 TI - Upper bound on strong-coupling corrections to the second upper critical field. PMID- 9944315 TI - Schrieffer-Wolff transformation for the Anderson Hamiltonian in a superconductor. PMID- 9944317 TI - Dynamics of fluxons in a system of coupled Josephson junctions. PMID- 9944318 TI - Thermoelectric effect as a test of exotic superconductivity. PMID- 9944319 TI - Effective-medium theory of an anisotropic conductor applied to the high-Tc superconductors. PMID- 9944320 TI - Single-crystal neutron-diffraction study of La2Cu0.95Li0.05O4. PMID- 9944322 TI - Numerical investigation of competing spin-spin interactions in a two-dimensional Ising model for La2-zCuO PMID- 9944321 TI - Ordered-defect structure in epitaxial YBa2Cu3O7-x thin films. PMID- 9944324 TI - Local structural variations in YBa2Cu PMID- 9944323 TI - Analysis of infrared reflection spectra of oxides of the La2CuO4 high -Tc superconductor family in polarized light. PMID- 9944325 TI - Crystal substructure and physical properties of the superconducting phase Bi4(Sr,Cr)6Cu4O16+x. PMID- 9944326 TI - Nearest-neighbor resonating-valence-bond state in two dimensions. PMID- 9944327 TI - Magnetic properties of oxygen-reduced, rare-earth based R1Ba2Cu3O7-x compounds with R=Gd, Dy, and Ho. PMID- 9944329 TI - Two-dimensional Heisenberg antiferromagnet: A numerical study. PMID- 9944328 TI - Muon depolarization and magnetic-field penetration depth in superconducting GdBa2Cu3Ox. PMID- 9944330 TI - Superconductivity in a narrow-band system with intersite electron pairing in two dimensions: A mean-field study. PMID- 9944331 TI - Canonical perturbation theory and the two-band model for high-Tc superconductors. PMID- 9944332 TI - Antiferromagnetic correlations of the resonating-valence-bond state. PMID- 9944333 TI - Real-space renormalization-group investigation of the randomly dilute q-state Potts model. PMID- 9944334 TI - Helium, tritium, and protium NMR studies of tritide-free aged PdTx. PMID- 9944335 TI - Quantum theory of nucleation in ferromagnets. PMID- 9944337 TI - Non-Peierls structural phase transitions in one-dimensional Peierls systems. PMID- 9944336 TI - Scaling properties of the elastic stiffness moduli of a random rigid-nonrigid network near the rigidity threshold: Theory and simulations. PMID- 9944339 TI - Rotational invariance and dipolar magnetoelastic effects: Application to TmSb. PMID- 9944338 TI - Classes for growth kinetics problems at low temperatures. PMID- 9944340 TI - Fractal dimension and scaling behavior of cracks in a random medium: "Frequency rank" distribution described by generalized random walks. PMID- 9944341 TI - Ground-state solutions of a frustrated Ising model in d dimensions. PMID- 9944342 TI - Specific-heat study of two-dimensional melting phenomena in the first oxygen layer on graphite. PMID- 9944343 TI - Extension theory for lattice Green functions. PMID- 9944344 TI - Macroscopic dynamics of uniaxial spin glasses. PMID- 9944345 TI - Peierls instability in the two-dimensional half-filled Hubbard model. PMID- 9944346 TI - Synchrotron magnetic x-ray measurements of the order parameter in Mn0.5Zn PMID- 9944347 TI - Temperature dependence of spin dynamics in the impurity-doped quasi-two dimensional antiferromagnet C2H5(NH3)2MnCl42+:Cu2+ PMID- 9944348 TI - Anomalously slow strain relaxation in quasicrystals and conventional crystals. PMID- 9944349 TI - Finite-size-scaling analysis of domain growth in the kinetic Ising model with conserved and nonconserved order parameters. PMID- 9944350 TI - Quantum Monte Carlo study of pressure melting in Yukawa systems. PMID- 9944351 TI - Influence of microstructure on the T-1/4 conductivity law of slowly deposited sputtered a-Si and a-Si:H. PMID- 9944353 TI - Critical exponents for an incommensurate structure with several length scales. PMID- 9944352 TI - Surface spin waves of semi-infinite two-sublattice ferrimagnets. PMID- 9944354 TI - Numerical study of the late stages of spinodal decomposition. PMID- 9944356 TI - Collective modes in an "ultraquantum crystal": Field-induced spin-density-wave phases. II. Coupling between longitudinal and transverse fluctuations. PMID- 9944355 TI - Collective modes in an "ultraquantum crystal." I. Field-induced spin-density-wave phases. PMID- 9944357 TI - Gap-exponent evolution near the upper critical dimension of directed percolation. PMID- 9944358 TI - Critical and scaling properties of the Aubry model in one-dimensional incommensurate systems. PMID- 9944359 TI - Electron-spin-relaxation times in Se-doped potassium dihydrogen phosphate ferroelectric crystals. PMID- 9944361 TI - Enhancement of exchange interactions in Bi- and La-substituted Y3Fe PMID- 9944360 TI - Free-energy formula for a superconducting alloy with localized states in the energy gap: Eliashberg formalism. PMID- 9944362 TI - Estimation of T1 for divalent cobalt ions from the temperature variation of the EPR linewidths for vanadyl in rubidium cobalt sulfate hexahydrate single crystals. PMID- 9944363 TI - Stark level 4T1(G) in MgO:Mn2+ PMID- 9944364 TI - Theory of how to distinguish a scalar from a tensor order parameter in the high Tc superconductors. PMID- 9944366 TI - High-pressure study on 60- and 90-K EuBa2Cu PMID- 9944367 TI - Anisotropic thermoelectric power and conductivity in single-crystal YBa22CuOy. PMID- 9944365 TI - Millimeter-wave surface resistance measurements in highly oriented YBa2Cu PMID- 9944368 TI - Tunneling measurements of the dependence of the energy gap on critical temperature in La2-xSrxCuO4-y. PMID- 9944369 TI - Magnetization of the 120-K Tl-Ca-Ba-Cu-O superconductor. PMID- 9944370 TI - Electronic structure changes and superconductivity in YBa2Cu PMID- 9944372 TI - t/U expansion for the Hubbard model. PMID- 9944371 TI - Evidence for homogeneous superconducting grains in high-Tc oxides. PMID- 9944373 TI - Epitaxial growth of YBa2Cu3O7 thin films on (100)-SrTiO3. PMID- 9944374 TI - Two-dimensional zone-center spin-wave excitations in La2CuO PMID- 9944375 TI - Superconductivity in the Y-Sr-Cu-O system. PMID- 9944376 TI - Theoretical calculation of the normal-state resistivity of the high-Tc oxide materials. PMID- 9944377 TI - Exploratory study of the electronic structure of fluorine-substituted YBa2Cu PMID- 9944379 TI - Electronic excitations of the YBa2Cu3O7-x superconductor: A study by transmission electron-energy-loss spectroscopy with an electron microprobe. PMID- 9944378 TI - Anelastic properties of single-phase YBa2Cu PMID- 9944380 TI - Electronic structure of high-Tc superconductors from soft-x-ray absorption. PMID- 9944381 TI - Photoemission study of single-crystalline (La1-xSrx PMID- 9944383 TI - Local lamellar structure in dense microemulsions. PMID- 9944382 TI - Exponential H and T decay of the critical current density in YBa2Cu3O7- delta single crystals. PMID- 9944384 TI - Critical exponents of spin-glass systems. PMID- 9944385 TI - Critical point of the second layer of CF4 adsorbed on graphite. PMID- 9944386 TI - "Proper" choice of the generalized scaling field for a mean-field spin glass. PMID- 9944387 TI - Influence functional and closed-time-path Green's function. PMID- 9944388 TI - Dipolar and quadrupolar phase transitions in the spin S=2 cubic crystal-field system. PMID- 9944389 TI - Topology of the lattice two-dimensional XY model. PMID- 9944390 TI - Migration volumes in PbF2 from recent elastic and expansivity data. PMID- 9944391 TI - Rigid spin rotation in amorphous rare-earth alloys. PMID- 9944392 TI - Two-stage feature of Hartmann-Hahn cross relaxation in magic-angle sample spinning. PMID- 9944393 TI - Low-field magnetic-relaxation effects in CeCu2Si PMID- 9944395 TI - Electron tunneling into the high-Tc superconductor Y-Ba-Cu-O. PMID- 9944394 TI - Incommensurate superlattice and 90 degrees twist boundaries in the superconducting phase of Bi-Sr-Ca-Cu-O. PMID- 9944396 TI - Symmetry breaking and nonlinear electrodynamics in the ceramic superconductor YBa2Cu3O7. PMID- 9944398 TI - Josephson-junction model of critical current in granular Y1Ba2Cu3O7- delta superconductors. PMID- 9944397 TI - Long-range antiferromagnetic order of the Cu in oxygen-deficient RBa PMID- 9944399 TI - Photon-stimulated desorption of neutral O2 from YBa2Cu3O7-x by core-level excitation. PMID- 9944400 TI - Incommensurate structure in the Bi-Sr-Ca-Cu-O 80-K superconductor. PMID- 9944402 TI - Magnetic field dependence of nonresonant microwave power dissipation in YBa2Cu PMID- 9944401 TI - Untwinned single crystals of YBa2Cu3O7- delta : An optical investigation of the a b anisotropy. PMID- 9944404 TI - Wetting across the antiferromagnetic layer. PMID- 9944403 TI - Infrared absorption of the paired-boson superconductor. PMID- 9944406 TI - New numerical transfer-matrix results for a quantum spin chain corresponding to (C6H11NH3)CuBr3 (CHAB). PMID- 9944405 TI - Accelerated simulations of XY spin glasses. PMID- 9944407 TI - Metamagnetic transition in the Kondo lattice compound CePt2Si PMID- 9944409 TI - Perturbation calculation around the two-dimensional Ising model. PMID- 9944408 TI - Calculation of spin waves in multilayered structures including interface anisotropies and exchange contributions. PMID- 9944410 TI - Frenkel-Kontorova model with nonconvex-interparticle interactions and strain gradients. PMID- 9944411 TI - New solvable model of polymer-chain adsorption at a surface. PMID- 9944412 TI - Spin-wave localization in ferromagnets with weak random-axes anisotropy. PMID- 9944413 TI - Spin polarons in the two-dimensional Hubbard model: A numerical study. PMID- 9944414 TI - Hole density and composition dependence of ferromagnetic ordering in Pb-Sn-Mn-Te. PMID- 9944416 TI - Thermal conductivity of some soliton-bearing magnetic systems. PMID- 9944415 TI - Possible evidence for a first-order magnetic phase transition on the Gd(0001) surface. PMID- 9944417 TI - Localization in the self-interaction-corrected density-functional formalism. PMID- 9944418 TI - Many-body perturbation theory applied to hydrogen interaction with lithium clusters. PMID- 9944419 TI - Tracer diffusion in amorphous Pd-Cu-Si. PMID- 9944421 TI - Classification of the phonon-focusing patterns of tetragonal crystals. PMID- 9944420 TI - Linear-muffin-tin-orbital (LMTO) supercell and LMTO recursion calculations for the electronic structure of metallic glasses: Ca7Al PMID- 9944422 TI - Characterization of surface and resonance phonons for the Ni(001)-c(2 x 2) system. PMID- 9944423 TI - Linear augmented-Slater-type-orbital method for electronic-structure calculations. V. Spin-orbit splitting in Cu3Au. PMID- 9944424 TI - Size effects in the electronic properties of hydrogen and helium embedded in small metal clusters: The self-consistent spherical-jellium-particle model. PMID- 9944426 TI - Density-functional theory for the dynamical response of molecules adsorbed on metal surfaces. PMID- 9944425 TI - Roughening of two-dimensional quasicrystal interfaces. PMID- 9944427 TI - Calculated lattice distortions at an isolated step on body-centered-cubic {100} surfaces. PMID- 9944428 TI - Dissociation energy of Mo2 and Mo2+ PMID- 9944429 TI - Polarization dependence of the near-edge x-ray-absorption fine structure for oxygen adsorbed on Ni(110). PMID- 9944430 TI - Local-density-approximation study of LaS and SmS. PMID- 9944431 TI - Local-density calculations of the magnetic and paramagnetic phases of TmSe and TmTe. PMID- 9944432 TI - ac-dc interference, complete mode locking, and origin of coherent oscillations in sliding charge-density-wave systems. PMID- 9944433 TI - Electron-phonon interaction and phonon dynamics in one-dimensional conductors. PMID- 9944434 TI - Observation of empty bulk states on Cu(100) by two-photon photoemission. PMID- 9944436 TI - Interface states in band-inverted semiconductor heterojunctions. PMID- 9944435 TI - Theory of conductivity in superlattice minibands. PMID- 9944437 TI - Resonance Raman scattering in pure and ultraheavily doped p-type germanium. PMID- 9944439 TI - Characterization of very narrow quasi-one-dimensional quantum channels. PMID- 9944438 TI - Properties of the optical transitions within the Mn acceptor in AlxGa PMID- 9944441 TI - Ground-state energy of the polaron gas in two-dimensional semiconductor microstructures. PMID- 9944440 TI - Conductance of an array of elastic scatterers: A scattering-matrix approach. PMID- 9944442 TI - Unified formalism for excess current noise in random-walk models. PMID- 9944444 TI - Structural relaxation and order in ion-implanted Si and Ge. PMID- 9944443 TI - Depopulation of subbands by magnetic and electric fields in gated AlxGa PMID- 9944445 TI - Self-energy operators and exchange-correlation potentials in semiconductors. PMID- 9944446 TI - Stress field in quantum systems. PMID- 9944447 TI - Fast-particle energy loss to a layered electron gas. PMID- 9944448 TI - Many-body effects in a layered electron gas. PMID- 9944449 TI - Origin of the optical transitions in ordered Si/Ge(001) superlattices. PMID- 9944450 TI - Further evidence for the C-line pseudodonor model in irradiated Czochralski-grown silicon. PMID- 9944451 TI - Silicon donor states in heavily doped thin GaAs-AlAs(001) superlattices. PMID- 9944452 TI - Band structure of ZnSe-ZnTe superlattices. PMID- 9944453 TI - Thermal modulation of the optical properties of amorphous semiconducting films. PMID- 9944455 TI - Magnetotransport in a two-dimensional electron gas with externally induced spatial inhomogeneities. PMID- 9944454 TI - Adsorption and growth of Sn on Si(100) from synchrotron photoemission studies. PMID- 9944456 TI - Nonlinear-process-induced period doubling of a picosecond transient grating in CdS. PMID- 9944457 TI - Band-gap tailoring of ZnO by means of heavy Al doping. PMID- 9944458 TI - Electrons and holes in InSb under crossed magnetic and stress fields. I. Theory. PMID- 9944459 TI - Electrons and holes in InSb under crossed magnetic and stress fields. II. Recombination radiation. PMID- 9944461 TI - Electrons and holes in InSb under crossed magnetic and stress fields. IV. Stimulated Raman scattering in the valence bands. PMID- 9944460 TI - Electrons and holes in InSb under crossed magnetic and stress fields. III. Magnetoreflection. PMID- 9944463 TI - Analytical approach to diffusion of hot carriers in n-type GaAs with Gamma -L-X band structure. PMID- 9944462 TI - Full-potential linear muffin-tin-orbital method. PMID- 9944464 TI - Temperature-dependent reaction and atomic redistribution for Ti/GaAs(100) interfaces. PMID- 9944465 TI - Time-resolved photoinduced absorption of oriented trans-polyacetylene in the picosecond to microsecond range. PMID- 9944466 TI - Effect of a parallel magnetic field on tunneling in GaAs/AlxGa PMID- 9944467 TI - Cluster polarization in Sr1-xCexF2+x: Hopping transport in fractal structures. PMID- 9944468 TI - Improved theoretical methods for studies of defects in insulators: Application to the F center in LiF. PMID- 9944469 TI - Time-resolved photoluminescence of Fe3+ ions in fluorozirconate glass. PMID- 9944470 TI - Nonlinear resonant attenuation in glasses and spectral diffusion. PMID- 9944471 TI - Localization of multivibrational excitations. PMID- 9944472 TI - Frequency-dependent transport properties of UPt3. PMID- 9944474 TI - Interpretation of activated resistivity in the quantum Hall regime by a statistical model of inhomogeneities. PMID- 9944473 TI - Screening of La core holes in LaAl2. PMID- 9944475 TI - Low-temperature specific heat of MoSi2. PMID- 9944477 TI - Electrical conduction and trapping distributions in tellurium oxide films. PMID- 9944476 TI - Quantum lattice fluctuation and subgap optical absorption in trans-polyacetylene. PMID- 9944478 TI - Measurement of the Debye-Waller factor for He-LiF(001). PMID- 9944479 TI - Erratum: Collective excitations of semi-infinite superlattice structures: Surface plasmons, bulk plasmons, and the electron-energy-loss spectrum PMID- 9944480 TI - Erratum: Wigner-function model of a resonant-tunneling semiconductor device PMID- 9944482 TI - Radiation-enhanced diffusion in amorphous Ni-Zr alloys. PMID- 9944481 TI - Lack of evidence for ferromagnetism in the vanadium monolayer on Ag(001). PMID- 9944483 TI - Correlation between electron loss and inverse photoemission measurements of alkali metals on metal surfaces. PMID- 9944485 TI - Apparent barrier height in scanning tunneling microscopy. PMID- 9944484 TI - Fluctuation effects on the cyclotron resonance spectrum for a two-dimensional electron gas. PMID- 9944486 TI - Benzene on Pd(110): The first example of nonparallel adsorption. PMID- 9944487 TI - Cohesive properties of solids calculated with the simplified total-energy functional of Harris. PMID- 9944488 TI - Resonant electron surface-barrier scattering on W(001). PMID- 9944489 TI - Equivalent-crystal theory of oscillatory surface relaxation. PMID- 9944490 TI - Electromodulation of the electronic structure and optical properties of PMID- 9944492 TI - Quantum Hall effect and helicon absorption in a superlattice. PMID- 9944491 TI - Role of elastic strain and relaxation on the molecular-beam epitaxial growth of III-V alloy pseudomorphic layers. PMID- 9944493 TI - Anisotropic drift mobility in hydrogenated amorphous silicon. PMID- 9944494 TI - Unoccupied surface-state band on Si(111)1 x 1-Ge. PMID- 9944495 TI - Observation of a metastable precursor for adsorption of oxygen on Si(111) and the activation energy for chemisorption. PMID- 9944496 TI - Dynamical correlation corrections to band-edge discontinuities in Si/GaP superlattices. PMID- 9944497 TI - Effects of spectral diffusion in incoherent photon-echo experiments. PMID- 9944498 TI - Distribution of barriers in (KBr)1-x(KCN)x: Dielectric response and specific heat. PMID- 9944499 TI - Exact eigenvalue equation for a finite and infinite collection of muffin-tin potentials. PMID- 9944500 TI - Cluster multiple-scattering theory for medium-energy electron diffraction. PMID- 9944501 TI - Mechanism for reactive chemistry at metal-semiconductor interfaces. PMID- 9944502 TI - Incommensurate charge-density wave and internal symmetries. PMID- 9944503 TI - Ellipsometric studies of magnetic phase transitions of Fe-Rh alloys. PMID- 9944505 TI - Hardening of the Coulomb gap by electronic polarons. PMID- 9944504 TI - Electronic structure of light-impurity-vacancy complex cluster in iron. PMID- 9944506 TI - Solvable model of multichannel localization. PMID- 9944507 TI - Photoemission from small particles of Ag and Au. PMID- 9944508 TI - Chemical and elastic effects on isostructural phase diagrams: The epsilon -G approach. PMID- 9944510 TI - Electronic structure of metallic liquid Se-Te alloys. PMID- 9944509 TI - Probability distributions in a two-parameter scaling theory of localization. PMID- 9944511 TI - Tensor-product structure of a new electromagnetic propagator for nonlocal surface optics of metals. PMID- 9944512 TI - Theoretical estimation of the electric-field gradient in amorphous alloys. PMID- 9944513 TI - Jahn-Teller effect and asymptotic behavior of the recursion-method coefficients. PMID- 9944514 TI - Electronic structure of cobalt disilicide. PMID- 9944515 TI - Electronic structure and properties of CoSi2. PMID- 9944516 TI - Ionization probability of sputtered atoms: Band-structure and collisional effects. PMID- 9944517 TI - High-resolution NMR in bistetramethyltetraselenafulvalenium salts PMID- 9944518 TI - Exact Hartree-Fock exchange in one-dimensional metals. PMID- 9944519 TI - Third-order elastic constants and energy convexity of deformed cubic crystals under different choices of strain measures. PMID- 9944520 TI - Cu/Ag(111) interface studied by surface electron energy-loss fine-structure spectroscopy. PMID- 9944521 TI - Electron-electron interaction and localization in d and f transition metals. PMID- 9944522 TI - Current- and spin-density-functional theory for inhomogeneous electronic systems in strong magnetic fields. PMID- 9944523 TI - Jump rates for vacancy diffusion in a Lennard-Jones solid under nonhydrostatic stress. PMID- 9944524 TI - Scattering-theoretic approach to elastic one-electron tunneling through localized barriers: Application to scanning tunneling microscopy. PMID- 9944525 TI - Power spectra of two-phonon surface polaritons. PMID- 9944526 TI - Vibrational excitations in a-Si1-xGex:F, a-Si1-xGex:H, and Ga1-xAlxAs alloys. PMID- 9944527 TI - Tuning the interaction between spin-singlet and spin-triplet states of double donors with stress. PMID- 9944528 TI - Long-wavelength optical phonons in polar superlattices. PMID- 9944529 TI - Atomic structure of the arsenic-saturated Si(111) surface. PMID- 9944530 TI - Theory of silicon inversion-layer impurity states derived from constant-energy ellipsoids oriented parallel to the interface. PMID- 9944532 TI - Surface structure of thin epitaxial CoSi2 grown on Si(111). PMID- 9944531 TI - Far-infrared and electrical transport studies of oxide-charge-induced localized states in a quasi-two-dimensional system. PMID- 9944533 TI - Polarized spectral emittance from periodic micromachined surfaces. I. Doped silicon: The normal direction. PMID- 9944534 TI - Polarized spectral emittance from periodic micromachined surfaces. II. Doped silicon: Angular variation. PMID- 9944536 TI - Study of the fundamental linewidths of 1S-->nP donor transitions in ultrapure germanium. PMID- 9944535 TI - Interchain decay of soliton pairs in polyacetylene. PMID- 9944538 TI - Quantum size effects in optical properties of CdS-glass composites. PMID- 9944537 TI - Zeeman splitting of double-donor spin-triplet levels in silicon. PMID- 9944539 TI - New global energy-minimization method. PMID- 9944540 TI - Exact propagator of a two-dimensional random system. PMID- 9944541 TI - Persistent photoconductivity in semiconductors with defect clusters. PMID- 9944543 TI - Indirect optical absorption and radiative recombination in silver bromoiodide. PMID- 9944542 TI - Temperature dependence of the hyperfine interactions of 111Cd in germanium. PMID- 9944544 TI - Charge-transfer satellites in the 2p core-level photoelectron spectra of heavy transition-metal dihalides. PMID- 9944545 TI - Spin-lattice relaxation below 1 K: A new mechanism for unexpected nuclear spin relaxation. PMID- 9944546 TI - Polytope models for local icosahedral packing: An electronic structure analysis. PMID- 9944547 TI - Indirect-exchange interaction in copper. PMID- 9944548 TI - Symmetry-induced local magnetic moments in icosahedral Al-Mn alloys. PMID- 9944549 TI - Self-energy of a positronium atom near a metal surface. PMID- 9944551 TI - Comment on "Evolution of intermediate excitons in fluid argon and krypton" PMID- 9944550 TI - Core-exciton absorption in the F K absorption spectra of 3d transition-metal fluorides. PMID- 9944553 TI - Comment on "Microscopic stress tensors in quantum systems" PMID- 9944552 TI - Quantum-defect method and valence excitons in rare-gas solids. PMID- 9944554 TI - Reply to "Comment on 'Microscopic stress tensors in quantum systems' " PMID- 9944556 TI - Anomalous Th M3O1 x-ray emission spectrum of ThO2. PMID- 9944555 TI - Relation between electron localization properties and infrared quenching of photoconductivity in hydrogenated amorphous silicon. PMID- 9944557 TI - Electromodulation mechanisms for the uncoupled and coupled states of a GaAs/Ga0.82Al PMID- 9944558 TI - Effect of bulk inversion asymmetry on PMID- 9944559 TI - Luminescence of quantum-well exciton polaritons from microstructured AlxGa PMID- 9944560 TI - Resonant Raman scattering in metals at the interband absorption threshold. PMID- 9944561 TI - Elastic constants of sodium from molecular dynamics. PMID- 9944562 TI - Dynamics of tunneling to and from small metal particles. PMID- 9944563 TI - Electron-beam-induced "explosive" crystallization of amorphous Se80Te20 alloy thin films and oriented growth of crystallites. PMID- 9944564 TI - Atomistic analysis of the enhanced-modulus effect in metallic superlattices. PMID- 9944565 TI - Noble-metal-CdTe interface formation. PMID- 9944566 TI - Resonant enhancement of ultrasound attenuation in mixed-valence metals. PMID- 9944567 TI - Structure of the Fermi hole at surfaces. PMID- 9944568 TI - Prebreakdown energy absorption from intense laser pulses at 532 nm in NaCl. PMID- 9944569 TI - Structural study of amorphous hydrogenated and unhydrogenated titanium carbide thin films by extended x-ray-absorption fine structure and extended electron energy-loss fine structure. PMID- 9944570 TI - Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. PMID- 9944571 TI - Calculated thermal properties of metals. PMID- 9944572 TI - Mean-field-theory study of the energetics of icosahedral, decagonal, and dodecagonal quasicrystals. PMID- 9944573 TI - Far-infrared spectrum of lithium deposited on a gold electrode: Interpretation with use of a cluster model. PMID- 9944574 TI - Anisotropy of ion-beam-induced self-diffusion in pyrolytic graphite. PMID- 9944575 TI - Scattering of evanescent waves with application to atom-surface interactions. PMID- 9944576 TI - Chemical bond as a test of density-gradient expansions for kinetic and exchange energies. PMID- 9944577 TI - Cluster growth and core-electron binding energies in supported metal clusters. PMID- 9944578 TI - Cyclotron resonance of high-mobility two-dimensional electrons at extremely low densities. PMID- 9944579 TI - Unoccupied surface states of (1 x 1) Sb overlayers on GaAs(110) and InP(110). PMID- 9944581 TI - Dielectric screening in semiconductors. PMID- 9944580 TI - Surface and size effects for impurities in Si clusters. PMID- 9944582 TI - A site-percolation threshold for the diamond lattice with diatomic substitution. PMID- 9944583 TI - Theoretical and experimental studies of optical absorption in strained quantum well structures for optical modulators. PMID- 9944584 TI - Low-temperature photoacoustic spectra of BiI3 single crystals. PMID- 9944585 TI - Analytical representation of impedance using the Boltzmann equation for nonlinear two-terminal device behavior. PMID- 9944586 TI - Optical properties and indirect-to-direct transition of GaP/AlP (001) superlattices. PMID- 9944587 TI - Electronic and optical properties of ultrathin Si/Ge (001) superlattices. PMID- 9944588 TI - Two-photon magnetoabsorption of ZnTe, CdTe, and GaAs. PMID- 9944589 TI - Exact and approximate results for the mass of a two-dimensional polaron. PMID- 9944590 TI - Acoustic plasmons in a conducting double layer. PMID- 9944591 TI - Nonequilibrium theory of the optical Stark effect and spectral hole burning in semiconductors. PMID- 9944592 TI - (AmBn)x copolymers: A computational study of electronic and excitonic properties of quasi-one-dimensional superlattices. PMID- 9944594 TI - Dynamics of xenon, krypton, and methane monolayers in registry with graphite. PMID- 9944593 TI - Influence of surface charge on free-carrier density profiles in GaAs films: Application to second-harmonic generation by free carriers. PMID- 9944595 TI - Dynamics of solid neon monolayers. PMID- 9944596 TI - Two-photon absorption spectroscopy of precipitated phases of Eu2+ in KCl single crystals. PMID- 9944597 TI - Excited-state absorption spectra of V2+ in KMgF3 and MgF2. PMID- 9944598 TI - Problems with the determination of elastic constants from higher-order surface waves: Results for Al on NaCl. PMID- 9944599 TI - Comment on "Spectroscopy of excited states in In0.53Ga0.47As-InP single quantum wells grown by chemical-beam epitaxy" PMID- 9944600 TI - Relationship between the pseudo-Jahn-Teller effect and chemical rebonding. PMID- 9944601 TI - Pseudo-Jahn-Teller effect and chemical rebonding: Two distinct physical phenomena. PMID- 9944602 TI - Erratum: Effect of an applied magnetic field on interface excitations in finite layered structures PMID- 9944604 TI - Soft-acoustic-phonon mode at the phase transition in quasi-one-dimensional (NbSe4)3I. PMID- 9944605 TI - In situ determination of the structure of an electrodeposited monolayer using optical second-harmonic generation. PMID- 9944606 TI - Pressure study of metastability in Ga1-xAlxAs/GaAs:Si heterojunctions. PMID- 9944603 TI - Evidence for hydrogen motion in annealing of light-induced metastable defects in hydrogenated amorphous silicon. PMID- 9944607 TI - Temperature dependence of the quantized states in a GaAs-Ga1-xAlxAs superlattice. PMID- 9944608 TI - Epitaxial growth of GexSi PMID- 9944610 TI - Coupling between single-particle and collective excitations in a charge-density wave system: Field dependence of nonlinear conduction in the blue bronze K0.3MoO3. PMID- 9944609 TI - Characterization of the DX center in the indirect AlxGa PMID- 9944611 TI - Geometric structure of the Si(111):As-1 x 1 surface. PMID- 9944612 TI - Density-functional calculations of the electronic properties of metals by the spherical cellular method. PMID- 9944613 TI - Eigenvalue equation for a general periodic potential and its multipole expansion solution. PMID- 9944614 TI - Time-resolved thermal transport in compositionally modulated metal films. PMID- 9944615 TI - Conductance fluctuations in one-dimensional quasicrystals. PMID- 9944616 TI - Virtual-bound-state effects in core-level spectra of light rare-earth alloys. PMID- 9944618 TI - Excitation of surface polaritons via optical nonlinearities: Threshold behavior. PMID- 9944617 TI - Experimental electron-density-distribution study of potassium iron disulfide, a low-dimensional material. PMID- 9944619 TI - Imaginary parts of coupled electron and phonon propagators. PMID- 9944620 TI - Structure of Al-(Li,Mg)-Cu icosahedral alloys studied by pulsed neutron scattering. PMID- 9944621 TI - Kinetics of hydrogen chemisorption by niobium on surfaces. PMID- 9944623 TI - Calculated optical properties of semiconductors. PMID- 9944622 TI - Light diffraction by KTiOPO4, a quasi-one-dimensional ionic conductor, under a dc field. PMID- 9944624 TI - Stimulated Brillouin scattering of Alfven waves in compensated semiconductors. PMID- 9944625 TI - Determination of the Gd3+-Gd3+ exchange constants from susceptibility measurements on Pb1-xGdxTe. PMID- 9944626 TI - Band offsets and excitons in CdTe/(Cd,Mn)Te quantum wells. PMID- 9944627 TI - Amorphous Si/Ge heterojunctions: Band discontinuities and local order studied by photoemission spectroscopy. PMID- 9944629 TI - Helical polyacetylene: A first-principles approach. PMID- 9944628 TI - Phonon-assisted indirect recombination of bound excitons in N-doped GaP, including near-resonant processes. PMID- 9944630 TI - Hot-electron relaxation in GaAs quantum wells. PMID- 9944632 TI - Two-level approach to saturation properties in semiconductor materials. PMID- 9944631 TI - Amorphous hydrogenated silicon-carbon-tin alloy films. PMID- 9944633 TI - Nonlinear optics as a probe of chiral ordering in amorphous semiconductors. PMID- 9944635 TI - Very large optical nonlinearity of semiconductor microcrystallites. PMID- 9944634 TI - Magnetophonon resonance under hydrostatic pressure in GaAs-Al0.28Ga0.72As and Ga0.47In0.53As-Al0.48In0.52As heterojunctions. PMID- 9944637 TI - Growth-front instabilities in solid-state recrystallization of amorphous GaAs films. PMID- 9944636 TI - Ab initio bond self-interaction correction calculation of tetrahedrally bonded semiconductors and its application to superlattices by the most localized linear muffin-tin orbital method. PMID- 9944638 TI - Exchange enhancement of the spin splitting in a GaAs-GaxAl PMID- 9944640 TI - Microscopic atomic structure and stability of Si-Ge solid solutions. PMID- 9944639 TI - First-principles calculations of atomic and electronic structure of the GaAs(110) surface. PMID- 9944642 TI - Local-environment approach for deep-level defects in semiconductors: Application to the vacancy in silicon. PMID- 9944641 TI - Thermal growth of SiO2-Si interfaces on a Si(111)7 x 7 surface modified by cesium. PMID- 9944643 TI - Intersubband Auger recombination in a superlattice. PMID- 9944644 TI - Spin-lattice relaxation in p-type gallium arsenide single crystals. PMID- 9944645 TI - Stability and electronic structure of ultrathin PMID- 9944647 TI - "Ordered" structure in colloidal silica particle suspensions as studied by small angle x-ray scattering. PMID- 9944646 TI - Sublevels and excitons in GaAs-AlxGa1-xAs parabolic-quantum-well structures. PMID- 9944648 TI - 4f-ligand hybridization in CeF4 and TbF4 probed by core-level spectroscopies. PMID- 9944649 TI - Fully relativistic Korringa-Kohn-Rostoker coherent-potential-approximation embedded-cluster-method evaluation of short-range-order effects in substitutional alloys containing heavy elements. PMID- 9944651 TI - Wake potential of a swift ion near a metal surface. PMID- 9944650 TI - Autoionization emission for x-ray-excited Auger spectra in the Compton-scattering process. PMID- 9944653 TI - Hierarchical structure of a one-dimensional quasiperiodic model. PMID- 9944652 TI - Spin-polarized electronic structure of Cr impurities in ZnS. PMID- 9944655 TI - Comment on "Determination of valence-band discontinuity via optical transitions in ultrathin quantum wells" PMID- 9944654 TI - Bound impurity in GaAs-Ga1- kappa Al kappa As quantum-well wires. PMID- 9944656 TI - Reply to "Comment on 'Determination of valence-band discontinuity via optical transitions in ultrathin quantum wells' " PMID- 9944657 TI - Reply to "Comment on 'Solvated polaron in an ionic lattice' " PMID- 9944658 TI - NMR study of electronic properties of the chemisorption of CO on supported Pt catalysts. PMID- 9944660 TI - Four-wave-mixing spectroscopy of a Cr3+-doped transparent glass ceramic. PMID- 9944659 TI - Platinum-induced changes in the electronic structure of iron. PMID- 9944661 TI - Test of diffusion models for the superionic conductor beta -Ag3SBr by silver NMR at 1 bar and 7 kbar. PMID- 9944662 TI - Quantum theory of local stopping power for fast channeled ions. PMID- 9944663 TI - Electronically stimulated sputtering and luminescence from solid argon. PMID- 9944664 TI - Ortho-to-para conversion in solid tritium. I. Theoretical models. PMID- 9944666 TI - Implications of a nonlinearity in the theory of second sound in solids. PMID- 9944665 TI - Ortho-to-para conversion in solid tritium. II. Experimental values. PMID- 9944668 TI - Superconductivity and spin-density waves: Application to heavy-fermion materials. PMID- 9944667 TI - Effect of long-range Coulomb interactions on the superconducting transition in Josephson-junction arrays. PMID- 9944669 TI - Magnetic-field dependence of resonance recombination in spin-polarized atomic hydrogen. PMID- 9944671 TI - Statistical thermodynamics of strongly correlated electrons in a narrow band: Fermi liquid versus spin liquid. PMID- 9944670 TI - Current distributions of thermal switching in extremely underdamped Josephson junctions. PMID- 9944672 TI - Path-integral theory of the scattering of 4He atoms at the surface of liquid 4He. PMID- 9944673 TI - Discussion of x-ray-absorption near-edge structure: Application to Cu in the high Tc superconductors La1.8Sr PMID- 9944674 TI - Fast-neutron irradiation of YBa2Cu PMID- 9944675 TI - Dimerization in the two-dimensional Hubbard model. PMID- 9944677 TI - Low-temperature specific heat of the high-Tc superconductors La1.8Sr0.2CuO4- delta and RBa2Cu3O7- delta (R=Y, Eu, Ho, Tm, and Yb). PMID- 9944676 TI - Far-infrared properties of ab-plane oriented YBa2Cu PMID- 9944678 TI - Temperature-dependent far-infrared reflectance of La-Sr-Cu-O and La-Ca-Cu-O: Bardeen-Cooper-Schrieffer electrodynamics but uncertain energy gap. PMID- 9944679 TI - Superconductivity in argon-treated Y-Ba-Cu-O system. PMID- 9944680 TI - Interaction of holes in a Hubbard antiferromagnet and high-temperature superconductivity. PMID- 9944681 TI - Thermal and electronic properties of rare-earth Ba2Cu3Ox superconductors. PMID- 9944683 TI - Theory of high-temperature superconductivity. PMID- 9944682 TI - Chemical composition and electronic structure of high-temperature superconductors: Ba2EuCu3O7-x and La2-xSrxCuO4. PMID- 9944684 TI - Quantum kinetics of a superconducting tunnel junction: Theory and comparison with experiment. PMID- 9944685 TI - Quasiparticle spectra and specific heat of a normal Fermi liquid in a spin fluctuation model. PMID- 9944686 TI - Structure and excitations of liquid-helium films. PMID- 9944687 TI - Effect of a quartic anisotropy energy on the "spiral magnetic" coexistence state of superconductivity and ferromagnetism. PMID- 9944688 TI - Comparison between the correlated-basis-functions method and the density functional theory for inhomogeneous systems. PMID- 9944689 TI - Electron-phonon coupling in the actinides. PMID- 9944690 TI - Comparative optical reflectance study of the superconducting KHg-graphite and CsBix-graphite intercalation compounds. PMID- 9944691 TI - Anisotropic Ising model on the hexagonal-close-packed lattice. PMID- 9944692 TI - Magnetic and magnetoelastic properties of PrNi5 single crystal. PMID- 9944693 TI - Wetting and layering in the nearest-neighbor simple-cubic Ising lattice: A Monte Carlo investigation. PMID- 9944694 TI - Corrections to scaling at two-dimensional Ising transitions. PMID- 9944696 TI - Dynamic specific heat of spin glasses: Studies of a spin cluster. PMID- 9944695 TI - Polarization dependence of magnetic x-ray scattering. PMID- 9944697 TI - Studies of the electronic phase transition in Lu5Ir4Si10 and Lu5Rh4Si10 by 175Lu NMR. PMID- 9944698 TI - Superionic phase transition of doped fluorites. PMID- 9944699 TI - Birefringence dispersion study in (C12H25NH3)2ZnCl4 crystal near its isotropic point. PMID- 9944701 TI - Structure analysis of modulated molecular crystals: The modulated phase of thiourea as described by a molecular displacement model. PMID- 9944700 TI - Generating-function approach to the resonating-bond state on the triangular and square ladders. PMID- 9944702 TI - Fractal structure of diffusion and invasion fronts in three-dimensional lattices through the gradient percolation approach. PMID- 9944703 TI - Effects of transport coherence on the mutual annihilation of excitons. PMID- 9944704 TI - Temperature dependence of the low-frequency magnetic excitations in USb. PMID- 9944705 TI - Magnetic susceptibility of diluted magnetic (semimagnetic) semiconductors: Further evidence for superexchange. PMID- 9944706 TI - Magnetic properties of a degenerate Anderson impurity. PMID- 9944707 TI - Anderson localization in Liouville space: The effective dephasing approximation. PMID- 9944708 TI - Coherent backscattering of light in the presence of time-reversal-noninvariant and parity-nonconserving media. PMID- 9944709 TI - Nonconvex interactions: A mechanism for the occurrence of modulated order in condensed matter. PMID- 9944710 TI - Thermodynamics of the anisotropic electron gas in a magnetic field. PMID- 9944712 TI - Density-wave theory of dislocations in crystals. PMID- 9944711 TI - Molecular-dynamics study of the local motion in a glass model for Rb1 x(ND4)xD2PO4. PMID- 9944714 TI - Magnetoresistance in heavy-fermion alloys. PMID- 9944713 TI - Commensurate phases and the devil's staircase. PMID- 9944716 TI - Random coupling crossover in Ising ferromagnets. PMID- 9944715 TI - Paraelectric-ferroelectric phase transitions of KH2PO PMID- 9944717 TI - Monte Carlo simulations of two-dimensional randomly diluted networks of nonlinear resistors. PMID- 9944718 TI - Equation of state of solid molecular H2 and D2 at 5 K. PMID- 9944719 TI - Theory of a two-level system interacting with a degenerate electron gas. I. Partition function. PMID- 9944720 TI - Theory of a two-level system interacting with a degenerate electron gas. II. Scaling theory of a one-dimensional Coulomb gas. PMID- 9944721 TI - Frequency-dependent electric conductivity of field-induced spin-density waves in Bechgaard salts. PMID- 9944722 TI - Magnetoelastic properties of dysprosium aluminum garnet: Theory. PMID- 9944723 TI - New variational approach to the periodic Anderson model. PMID- 9944724 TI - Planar classical dipolar system on a honeycomb lattice. PMID- 9944726 TI - Lattice dynamics of crystals with tetragonal BaTiO3 structure. PMID- 9944725 TI - Q-factor measurements of the bulk resistivity and nonmetal-metal transitions in LaHx and CeHx (x >= 2.70). PMID- 9944727 TI - Calculations of magnetic x-ray dichroism in the 3d absorption spectra of rare earth compounds. PMID- 9944728 TI - Two-level model for the nonexponential Williams-Watts dielectric relaxation. PMID- 9944729 TI - Raman scattering study of ammonia up to 75 GPa: Evidence for bond symmetrization at 60 GPa. PMID- 9944730 TI - Molecular-dynamics theory of the temperature-dependent surface phonons of W(001). PMID- 9944731 TI - Magnetization of erbium in the ordered and paramagnetic phases. PMID- 9944732 TI - Transitions and modulated phases in centrosymmetric ferroelectrics: Mean-field and renormalization-group predictions. PMID- 9944734 TI - Ground state of the one-dimensional chiral XY model in a field. PMID- 9944733 TI - Critical dynamics, finite-size effects, and supersymmetry. PMID- 9944735 TI - Momentum dependence of the Stoner excitation spectrum of iron using spin polarized electron-energy-loss spectroscopy. PMID- 9944736 TI - Asymptotic behaviors of the waiting-time distribution function psi (t) and asymptotic solutions of continuous-time random-walk problems. PMID- 9944737 TI - Alternative Feynman-diagram method for the general-spin Kondo problem. PMID- 9944738 TI - Quasichemical approximation for lattice models with nonadditive interatomic interactions. PMID- 9944739 TI - Ground-state analysis of ordered superstructures in the basal plane of YBa2Cu PMID- 9944740 TI - Incoherent inelastic neutron scattering study of the low-frequency phonons in superconducting La1.85Sr0.15CuO4 and antiferromagnetic La2CuO4. PMID- 9944741 TI - Inequalities for Delta (T)/kBTc: A test for weak-coupling theory applied to high Tc superconductors. PMID- 9944742 TI - Model for the ground state of La2-zCuO4-y. PMID- 9944743 TI - Phase diagram of the superconducting oxide YBa2Cu3O6+ delta. PMID- 9944744 TI - Enhancement of the superconducting critical temperature in layered compounds. PMID- 9944746 TI - Bond-energy variables for Ising spin-glass dynamics. PMID- 9944745 TI - Polarized light scattering study of UPt3. PMID- 9944747 TI - EPR determination of the critical exponent of Mn2+-doped (NH PMID- 9944748 TI - High-field magnetic resonances in Cd1-xMnxTe at far-infrared energies. PMID- 9944749 TI - Pressure-induced phase transitions in LiNH4SO PMID- 9944750 TI - Anomalous layering of Fe(CO)5 adsorbed on graphite. PMID- 9944751 TI - Dynamics of self-trapping on a dimer with anharmonic coupling. PMID- 9944752 TI - Domain-growth kinetics of systems with soft walls. PMID- 9944753 TI - Erratum: Low-temperature structural phase transition in La2CuO4 PMID- 9944754 TI - Nuclear spin-lattice relaxation in 3He- PMID- 9944755 TI - Thermoelectric power and superconducting properties of Y1Ba PMID- 9944756 TI - Magnetization near a Lifshitz point in the high-Tc superconductors. PMID- 9944757 TI - Soft x-ray absorption and emission spectra and the electronic structure of the Ba2YCu3O7-x superconductor. PMID- 9944758 TI - Ion-channeling study of single-crystal YBa2Cu PMID- 9944759 TI - High-resolution x-ray microstructural study of single crystals of YBa2Cu PMID- 9944760 TI - Effect of oxygen deficiency on the normal and superconducting properties of YBa2Cu PMID- 9944761 TI - Electronic structure of La4BaCu PMID- 9944762 TI - Electron paramagnetic resonance of single-phase pellets of the high-Tc superconductor YBa2Cu PMID- 9944763 TI - Diffraction evidence for oxygen-vacancy ordering in annealed Ba2YCu3O7- delta (0.3 <~ delta <~ 0.4) superconductors. PMID- 9944764 TI - Coexistence of antiferromagnetism and superconductivity in a mean-field theory of high-Tc superconductors. PMID- 9944765 TI - Large static dielectric constant in the high-temperature phase of polycrystalline YBa2Cu3Ox. PMID- 9944767 TI - Positron-annihilation studies of the superconductivity transition in YBa2Cu PMID- 9944766 TI - Implications of crystal-field and intra-atomic interactions for the electronic structure of high-Tc superconductors. PMID- 9944768 TI - Possible twin-boundary effect upon the properties of high-Tc superconductors. PMID- 9944769 TI - Electronic properties and magnetism in high-Tc superconductors. PMID- 9944770 TI - Magnetic ordering in the high-temperature superconductor GdBa2Cu PMID- 9944771 TI - Quantum structural diagrams and high-Tc superconductivity. PMID- 9944772 TI - Flux distribution and penetration depth measured by muon spin rotation in high-Tc superconductors. PMID- 9944773 TI - Dynamics of spin fluctuations in lanthanum cuprate. PMID- 9944774 TI - R0(0) transition in the absorption spectrum of solid hydrogen deuteride (HD). PMID- 9944775 TI - Flux quantization in periodic networks containing tiles with irrational ratio of areas. PMID- 9944776 TI - Aperiodic superconducting phase boundary of periodic micronetworks in a magnetic field. PMID- 9944778 TI - Stability of anisotropic superconducting phases in UPt3. PMID- 9944777 TI - Long-range magnetic ordering in the high-Tc superconductors RBa PMID- 9944780 TI - Ground-state staggered magnetization of two-dimensional quantum Heisenberg antiferromagnets. PMID- 9944779 TI - Critical exponents and corrections to scaling for the two-dimensional self avoiding walk. PMID- 9944781 TI - Equilibrium magnetic fluctuations in a Ruderman-Kittel-Kasuya-Yosida spin glass. PMID- 9944783 TI - Nonuniversal behavior of the cluster properties in continuum systems. PMID- 9944782 TI - Ferromagnetic resonance of exchange-coupled magnetic layers. PMID- 9944784 TI - Al L2,3 and Mg double-ionization emission spectra of dilute Al in Mg alloys. PMID- 9944785 TI - Surface dielectric response of a semimetal: Electron-energy-loss spectroscopy of graphite. PMID- 9944786 TI - Elastic model for the partially coherent growth of metallic superlattices. I. Interdiffusion, strain, and misfit dislocations. PMID- 9944787 TI - Elastic model for the partially coherent growth of metallic superlattices. II. Coherent to a partially coherent transition. PMID- 9944788 TI - Electronic structure and properties of sputtered Ta-Cu films. PMID- 9944789 TI - Solid-state reaction in Ce/Ni multilayers studied by x-ray-absorption spectroscopy. PMID- 9944790 TI - Local fluctuations and ordering in liquid and amorphous metals. PMID- 9944792 TI - Positronium desorption of positrons bound to alkali-metal-covered Ni surfaces. PMID- 9944791 TI - Total-electron-yield current measurements for near-surface extended x-ray absorption fine structure. PMID- 9944794 TI - Quantum diagrams of transition-metal-metalloid defect structures. PMID- 9944793 TI - Role of density in Raman scattering of iodine. PMID- 9944795 TI - Adsorption of molecules on free-electron-like metals: CO on Al(100). PMID- 9944796 TI - Metal-insulator transition of elemental iodine under pressure. PMID- 9944797 TI - Relation of transport properties to microstructure of implanted Ni PMID- 9944799 TI - In situ infrared spectroscopy of the oxide-liquid interface: Pyridine on aluminum oxide. PMID- 9944798 TI - Diamagnetic susceptibility of a dense electron gas. PMID- 9944800 TI - Observation of stress-tuned magnetic-field-induced anticrossing in As-doped germanium. PMID- 9944802 TI - Electric field dependence of intrasubband polar-optical-phonon scattering in a quantum well. PMID- 9944801 TI - Ab initio study of charged polyenes as charge-carrier models in conducting polymers. PMID- 9944803 TI - Dispersion and dipole activity of surface phonons on Si(111) 2 x 1. PMID- 9944804 TI - Optical-absorption coefficient of In1-xGaxAs/InP. PMID- 9944805 TI - Optically detected magnetic resonance studies of the 1.911-eV Cu-related complex in GaP. PMID- 9944806 TI - Two deep (PGa-Cu)-related neutral complex defects in GaP studied with optically detected magnetic resonance. PMID- 9944807 TI - Transfer processes for excitons bound to complex defects in GaP studied by optical detection of magnetic resonance. PMID- 9944808 TI - Effect of electron-electron scattering on nonequilibrium transport in quantum well systems. PMID- 9944810 TI - Nonradiative recombination via deep impurity levels in semiconductors: The excitonic Auger mechanism. PMID- 9944809 TI - Time dynamics of free- and bound-exciton luminescence in CdSe under low- and high intensity excitation. PMID- 9944812 TI - Phonon interactions at the deep platinum acceptor in silicon. PMID- 9944811 TI - Theoretical calculations of hyperfine interactions of the Jahn-Teller distorted single vacancy in silicon. PMID- 9944813 TI - Metallic CaSi2 epitaxial films on Si(111). PMID- 9944814 TI - Effects on vibrational and electronic properties of removing hydrogen atoms in hydrogenated amorphous silicon. PMID- 9944815 TI - Plasmon broadening and temperature effects on the plasmon-phonon-assisted recombination in silicon. PMID- 9944816 TI - Nonequilibrium phonon effects on hot-electron transport in semiconductor heterojunctions. PMID- 9944817 TI - Optical transitions in neutron-irradiated MgAl2O PMID- 9944819 TI - Simulation of the structure of amorphous silicon dioxide. PMID- 9944818 TI - Dynamic effects of the impurity potential and electron interactions on a soliton in trans-polyacetylene. PMID- 9944820 TI - Raman scattering from solid argon at high pressure. PMID- 9944822 TI - Asymptotic behavior of relaxation and reconstruction near crystalline surfaces. PMID- 9944821 TI - Use of local-density pseudopotentials in Hartree-Fock calculations. PMID- 9944824 TI - Multilayer reconstruction and vibrational properties of W(001). PMID- 9944823 TI - Valence of Sm adsorbed on Pd(001). PMID- 9944825 TI - Difference in total energy between bcc and fcc iron. PMID- 9944827 TI - Resonant and nonresonant polarons in semiconductors. PMID- 9944826 TI - Electromagnetic generation of acoustic waves in metals. PMID- 9944828 TI - Influence of oxygen in the formation of isoelectronic complexes in implanted Si:In. PMID- 9944829 TI - High-energy x-ray anomalous dispersion correction for silicon. PMID- 9944831 TI - Low-temperature conductivity of semiconductors doped heavily with nonhydrogenic impurities. PMID- 9944830 TI - Geometric structure of the Si(111) sqrt 3 x sqrt 3-Ga surface. PMID- 9944832 TI - Exciton-tunneling-lifetime enhancement by the Coulomb interaction in a quantum well with a perpendicular field. PMID- 9944834 TI - Observation of the wave-vector dependence of the central mode by hyper-Raman scattering and the Au-optical-phonon-central-mode coupling in CsH2PO PMID- 9944833 TI - Simple derivation of exponential tails in the density of states. PMID- 9944835 TI - Comment on "Atomic model for the EL2 defect in GaAs" PMID- 9944836 TI - Erratum: Magnetoplasma modes in thin films in the Faraday configuration PMID- 9944838 TI - Dynamics of the dissipative multiwell system. PMID- 9944837 TI - Resonance broadening of the light-hole exciton in GaAs/AlxGa PMID- 9944839 TI - Model dielectric matrices for quasiparticle self-energy calculations. PMID- 9944840 TI - Resonant Raman-active acoustic phonons in the mixed amorphous-microcrystalline phase of ion-implanted GaAs. PMID- 9944841 TI - Charge-density waves observed at 4.2 K by scanning-tunneling microscopy. PMID- 9944842 TI - Real-space and magnetic-field correlation of quantum-resistance fluctuations in the ballistic regime in narrow GaAs-AlxGa PMID- 9944843 TI - Structure of Si-Ge amorphous-semiconductor heterojunctions. PMID- 9944844 TI - Optically detected magnetic resonance in oxygen-doped GaP. PMID- 9944845 TI - Magnetoresistance in a GaAs-AlxGa1-xAs heterostructure with double subband occupancy. PMID- 9944846 TI - Theory of heavy-hole magnetoexcitons in GaAs-(Al,Ga)As quantum-well heterostructures. PMID- 9944847 TI - Surface phonon dispersion on Cu(111). PMID- 9944848 TI - Structural perfection of the Si(111)-(1 x 1) As surface. PMID- 9944849 TI - Donor-hydrogen complexes in passivated silicon. PMID- 9944850 TI - Fabrication of a GaAs quantum-well-wire structure by Ga focused-ion-beam implantation and its optical properties. PMID- 9944852 TI - First-principles calculation of the electric-field gradient in hcp metals. PMID- 9944851 TI - Theory of dielectric breakdown in metal-loaded dielectrics. PMID- 9944853 TI - Localized states and self-similar states of electrons on a two-dimensional Penrose lattice. PMID- 9944855 TI - Studies of angle-resolved photoelectron spectra from oriented NiCO: A model for adsorbed CO. PMID- 9944854 TI - Second-harmonic generation at metal surfaces using an extended Thomas-Fermi-von Weizsacker theory. PMID- 9944856 TI - Transport properties of TaSe3. PMID- 9944857 TI - Anisotropic packing and diffraction-peak shifts in icosahedral glasses. PMID- 9944858 TI - Local-environment effects on the density of states and substitutional impurities in random alloys. PMID- 9944859 TI - Resistivity study on the production and migration of helium in LuTr (r <= 0.20). PMID- 9944860 TI - Nonlocality in the density-functional description of bonding in Li2, N2, O2, and F2. PMID- 9944861 TI - Effect of peening on structure and volume in a liquid-quenched Pd0.835Si0.165 glass. PMID- 9944863 TI - Electronic structure and geometries of heteroatomic clusters. PMID- 9944862 TI - Observation of Kondo resonance in YbAl3. PMID- 9944864 TI - Empirical band calculations of the optical properties of d-band metals. V. Practical aspects of a bcc interpolation scheme. PMID- 9944866 TI - Two-dimensional boundary conditions and finite-size effects in angle-resolved photoelectron emission spectroscopy, low-energy electron diffraction, and high resolution electron-energy-loss spectroscopy. PMID- 9944865 TI - Empirical band calculations of the optical properties of d-band metals. VI. The optical conductivity of ferromagnetic iron. PMID- 9944867 TI - Interplay of surface misfit and monatomic steps on crystal surfaces. I. Basic theory. PMID- 9944868 TI - Interplay of surface misfit and monatomic steps on crystal surfaces. II. Dependence of energy of formation on step orientation. PMID- 9944869 TI - Interstitial migration of hydrogen and helium in platinum. PMID- 9944871 TI - Raman-scattering study of the high-pressure phase transition in Zn1-xMnxSe. PMID- 9944870 TI - Optical studies of porous glass media containing silver particles. PMID- 9944872 TI - Transient and steady-state electron transport in GaAs/AlxGa1-xAs heterojunctions at low temperatures: The effects of electron-electron interactions. PMID- 9944874 TI - Surface metallization of silicon by potassium adsorption on Si(001)-(2 x 1). PMID- 9944873 TI - Polaron band theory as linearized soliton theory. PMID- 9944876 TI - Electronic structure due to hydrogen and vanadium as substitutional impurities in InP. PMID- 9944875 TI - Thermal recovery of photoquenched EL2 infrared absorption in GaAs. PMID- 9944878 TI - Hot-electron transport for many-valley semiconductors by the method of nonequilibrium statistical operators. PMID- 9944877 TI - X-ray structural study of amorphous Mo-Ge films. PMID- 9944879 TI - Stability of bulk and pseudomorphic epitaxial semiconductors and their alloys. PMID- 9944880 TI - Dispersive-linear-chain approach to the interpretation of surface phonons: Application to GaSe(001) and TaSe2(001). PMID- 9944881 TI - Resonant Raman scattering on localized states due to disorder in GaAs1-xPx alloys. PMID- 9944882 TI - Excitonic transitions in GaAs/GaxAl1-xAs quantum wells observed by photoreflectance spectroscopy: Comparison with a first-principles theory. PMID- 9944884 TI - Molecular-cluster studies of defects in silicon lattices. III. Dangling-bond reconstruction at the core of a 90 degrees partial dislocation in silicon. PMID- 9944885 TI - Angle-resolved photoemission study of CuI. PMID- 9944883 TI - Landau-level width: Magnetic-field and temperature dependences. PMID- 9944886 TI - Picosecond radiationless electronic relaxation of the Ga0(1) and In0(1) defects in KCl. PMID- 9944887 TI - Mossbauer studies of the 6.2-keV gamma rays of 181Ta in 2H-LixTaS2 (0 <= x <= 0.95). PMID- 9944888 TI - Polaron effective mass. PMID- 9944890 TI - Filling-factor-dependent cyclotron mass in space-charge layers on GaAs. PMID- 9944889 TI - Lattice mechanics of divalent-metal carbonates. PMID- 9944892 TI - Ultrasonic velocity, attenuation, and nonlinearity constant in pure and Cd-doped KCl. PMID- 9944891 TI - Effective-mass-mismatch-induced intersubband absorption line broadening in semiconductor quantum wells. PMID- 9944893 TI - Monitoring the surface oxidation process with an energy-tunable monoenergetic positron beam. PMID- 9944894 TI - Electron correlation and magnetism in NiS: Implications of photoemission spectra. PMID- 9944895 TI - Vibrational-mode theory of acceptor-hydrogen complexes in silicon. PMID- 9944896 TI - Well-resolved higher excited states of the light- and heavy-hole free excitons in a 225-A PMID- 9944897 TI - Chemical bond at the Si(111)/Yb interface via Auger line-shape spectroscopy analysis. PMID- 9944899 TI - Difference between the quasiparticle and the Kohn-Sham-Fermi surfaces. PMID- 9944898 TI - Possibility of charge transfer between dimer atoms on Si(100)-(2 x 1). PMID- 9944901 TI - Calculation of electronic and structural properties of BC3. PMID- 9944900 TI - Theory of magnetoexcitons in quantum wells. PMID- 9944902 TI - Evidence of phonon drag in the thermopower of a GaAs-Ga0.68Al PMID- 9944903 TI - One-dimensional diffusion-limited staging transition in graphite intercalation compounds. PMID- 9944904 TI - Muon spin rotation and magnetic order in the heavy-fermion compound URu2Si2. PMID- 9944905 TI - Nuclear magnetic and quadrupole resonance in metallic powders in the presence of strong quadrupole interaction: Rhenium metal. PMID- 9944906 TI - Characterization of multilayer rough surfaces by use of surface-plasmon spectroscopy. PMID- 9944908 TI - Jahn-Teller effects in the near-infrared absorption spectrum of MgO:Fe2+ PMID- 9944907 TI - Desorption of neutrals by temporary ionization of atoms and molecules physisorbed on a metal surface: Quantum-mechanical versus classical approach. PMID- 9944909 TI - Distribution function for the orientational order parameters in solid H2 and D2. PMID- 9944911 TI - Structural and electronic properties of hydrogen in the potassium-hydrogen graphite ternary intercalation compound C8KH PMID- 9944910 TI - Fourier-transform method for accurate analysis of Mossbauer spectra. PMID- 9944912 TI - Optical and EPR investigations of Np4+ in single crystals of ZrSiO4. PMID- 9944914 TI - Structure, soft modes, and superconductivity in Cl-doped cadmium sulfide. PMID- 9944913 TI - Single-crystal Mossbauer measurement of the critical exponent beta in the random exchange Ising system Fe0.9Zn PMID- 9944915 TI - Quantum statistical mechanics of an array of resistively shunted Josephson junctions. PMID- 9944917 TI - Momentum-dependent electron self-energy in nearly ferromagnetic systems: Comparison of spin fluctuations and phonons. PMID- 9944916 TI - Elastic constants of NbC and MoN: Instability of B1-MoN. PMID- 9944918 TI - Superconductivity in primitive hexagonal germanium. PMID- 9944919 TI - Evolution and structure of hot drops in a cold fluid. PMID- 9944920 TI - Lagrangian of superfluid 3He. PMID- 9944921 TI - Novel tunneling technique for measuring electron scattering rates in superconductors: Application to Sn and Sn-In films. PMID- 9944922 TI - Andreev scattering at a rough surface of 3He-B. PMID- 9944923 TI - Suppression of heavy fermions by high fields in CeCu6. PMID- 9944925 TI - Phase separation in isotopic helium mixtures. PMID- 9944924 TI - Analog simulation of coupled superconducting weak links: Locking and chaos. PMID- 9944926 TI - Theory of the normal resistivity and specific heat of high-temperature superconducting materials. PMID- 9944927 TI - Far-infrared spectroscopy of RBa2Cu3Ox with variations in R and x. PMID- 9944928 TI - Extended x-ray-absorption fine-structure experiment on the high-Tc superconductor YBa2Cu PMID- 9944930 TI - Effect of disorder on the resonating-valence-bond model of high-temperature superconductivity: Relationship to experiments. PMID- 9944929 TI - Raman and infrared studies of Sr2TiO4: A material isomorphic to (La,Sr)2CuO4 superconductors. PMID- 9944931 TI - Correlation of dopant-induced optical transitions with superconductivity in La2 xSrxCuO4- delta. PMID- 9944932 TI - Dynamical response of antiferromagnets in an oblique magnetic field: Application to surface magnons. PMID- 9944933 TI - Effect of irradiation-induced defects in the lock-in transition of Rb2ZnBr4. PMID- 9944934 TI - Phase transitions in magnetic superlattices. PMID- 9944935 TI - Vibronically induced two-exciton bands in KMnF3 and RbMnF3. PMID- 9944936 TI - Tunneling through a spin-polarizing barrier: Boltzmann-equation study. PMID- 9944938 TI - Dipolar broadening in magnetically diluted lattices. PMID- 9944937 TI - Constant-phase-angle and power-law regimes in the frequency response of a general determinate fractal circuit. PMID- 9944939 TI - Topology and elastic properties of depleted media. PMID- 9944940 TI - Neutron scattering study of the itinerant-electron magnet YMn2. PMID- 9944941 TI - Combined extended x-ray-absorption fine structure and diffraction study of Kr adsorbed on graphite. PMID- 9944943 TI - Specific-heat measurements of HoxY PMID- 9944942 TI - Ordering in the quenched two-dimensional axial next-nearest-neighbor Ising model. PMID- 9944944 TI - Self-consistent full-potential linearized-augmented-plane-wave local-density electronic-structure studies of magnetism and superconductivity in C15 compounds: ZrZn2 and ZrV2. PMID- 9944946 TI - Dependence of the conductivity of a porous medium on electrolyte conductivity. PMID- 9944945 TI - High-field magnons in ferromagnets with random anisotropy axes. PMID- 9944947 TI - Phase transitions of ethylene on graphite. PMID- 9944948 TI - Two-dimensional crystalline phases of CF3H adsorbed on graphite. PMID- 9944949 TI - Anisotropic renormalization-group transformations. PMID- 9944950 TI - Lattice-soliton scattering in nonlinear atomic chains. PMID- 9944951 TI - Electron polaron effects in heavy-electron systems. PMID- 9944952 TI - Equilibrium thermodynamics of models of hydrogen bonding in lipid bilayer membranes: The amide model. PMID- 9944953 TI - Density of states of a sparse random matrix. PMID- 9944954 TI - Magnetic susceptibility and spin-glass behavior in the pseudo-one-dimensional mixed system PMID- 9944956 TI - Light scattering in strongly scattering media: Multiple scattering and weak localization. PMID- 9944955 TI - Yang-Lee edge singularity in systems with correlated disorder. PMID- 9944958 TI - Ferroelectric phase transition in RbH2PO PMID- 9944957 TI - Spin fluctuations in Y(Co1-xAlx PMID- 9944959 TI - Theory of the magnetization and exchange-enhanced susceptibility of alloys. I. Zero-temperature susceptibility of paramagnetic alloys in the random-phase approximation. PMID- 9944961 TI - Numerical solution of spin systems and the S=(1/2 Heisenberg antiferromagnet using guided random walks. PMID- 9944960 TI - Theory of the magnetization and exchange-enhanced susceptibility of alloys. II. Zero-temperature magnetization and susceptibility in the presence of moments. PMID- 9944962 TI - Coherent backscattering of light by disordered media: The vector nature of a photon. PMID- 9944963 TI - Raman spectroscopy in high-temperature superconducting materials. PMID- 9944964 TI - Transport mechanisms in Y1Ba2Cu3O6+ delta superconductors in the metallic and the semiconducting regimes. PMID- 9944966 TI - Resonating valence bonds and d-wave superconductivity. PMID- 9944965 TI - Raman spectra of YBa2Cu PMID- 9944967 TI - Field-induced anisotropy in high-Tc superconductors. PMID- 9944968 TI - Theory of the Jahn-Teller-Kondo effect. PMID- 9944969 TI - Ultrasonic-attenuation measurements in single-phased YBa2 PMID- 9944971 TI - Cooperative weak links in sintered Y-Ba-Cu-O superconductor. PMID- 9944970 TI - Oxygen order-disorder transition in the superconductor YBa2Cu3O6+ delta. PMID- 9944972 TI - Ultramicroanalysis of Y-Ba-Cu-O ceramics with the atom-probe microscope. PMID- 9944973 TI - Vibrating-reed studies of flux pinning in the superconducting metallic glass Zr70Cu PMID- 9944974 TI - Correction to acoustic transmission through a rough solid-superfluid 4He interface (due to coupling between pressure and temperature waves in the liquid). PMID- 9944975 TI - Effective-medium approach for the conductivity of dispersed ionic conductors. PMID- 9944976 TI - Crystal structure of Li2FeS2. PMID- 9944977 TI - Behavior of an Ising model with randomly mixed classical and quantal spins. PMID- 9944979 TI - Dynamic shear modulus for two-dimensional bond percolation. PMID- 9944978 TI - Static magnetic susceptibility of Zn1-xMnxSe. PMID- 9944980 TI - Finite-size scaling for the restricted solid-on-solid model of the two dimensional wetting transition. PMID- 9944981 TI - Stretched exponential decay of the spin-correlation function in the kinetic Ising model below the critical temperature. PMID- 9944982 TI - Theory of nonlinear standing waves in a two-dimensional system of charged particles. PMID- 9944983 TI - Erratum: Low-temperature neutron irradiation effects on superconducting Y-Ba-Cu oxides PMID- 9944984 TI - Preparation of superconducting YBa2Cu3O7 from the corresponding metal formates. PMID- 9944985 TI - Spin-fluctuation-induced superconductivity in YBa2Cu PMID- 9944987 TI - Inverse photoemission studies of the high-Tc superconductors. PMID- 9944986 TI - Evidence for peroxide formation in superconducting YBa2-xLaxCu3O7+/- delta. PMID- 9944988 TI - Synchrotron-radiation photoemission studies of interface formation between metals and superconductors: Al and In on YBa2Cu PMID- 9944989 TI - Superconductivity above 20 K in the Ba-K-Bi-O system. PMID- 9944990 TI - Interaction of H2O with a high-temperature superconductor. PMID- 9944991 TI - Topological defect condensation and high-temperature superconductivity. PMID- 9944992 TI - Ion-beam-induced destruction of superconducting phase coherence in YBa2Cu3O7- delta. PMID- 9944994 TI - Low-temperature specific heat of single-crystal YBa2Cu3O7- delta. PMID- 9944993 TI - Effective Hamiltonian for the superconducting Cu oxides. PMID- 9944995 TI - Softening of Cu-O vibrational modes as a precursor to onset of superconductivity in EuBa2Cu PMID- 9944996 TI - Mossbauer study of the lattice dynamics in 119Sn-doped superconducting and nonsuperconducting YBa2Cu PMID- 9944997 TI - Large-n limit of the Heisenberg-Hubbard model: Implications for high-Tc superconductors. PMID- 9944998 TI - Chaos in pulse-driven Josephson junctions. PMID- 9944999 TI - Charge fluctuations, spin fluctuations, and superconductivity in the Anderson lattice model of heavy-fermion systems. PMID- 9945000 TI - Systems with resonating-valence-bond ground states: Correlations and excitations. PMID- 9945001 TI - Theory of charge-imbalance relaxation in anisotropic heavy-fermion superconductors. PMID- 9945003 TI - Cell-dynamics approach to late-stage domain growth in phase-separating systems. PMID- 9945002 TI - Theory of deep inelastic neutron scattering on quantum fluids. PMID- 9945004 TI - Observed microscopic structure in the simulation of multilayers. PMID- 9945005 TI - High-field magnetoconductivity of electrons on hydrogen. PMID- 9945007 TI - Resonating-valence-bond state: Comments on the antiferromagnetic ordering of the two-dimensional Heisenberg model. PMID- 9945006 TI - Model for the orientation, magnetic field, and temperature dependence of the specific heat of CeCu6. PMID- 9945008 TI - Universality of surface critical behavior of the three-dimensional Ising model in a random surface field. PMID- 9945009 TI - First-order wetting transition in d=2 systems with short-range interactions: Exact solution. PMID- 9945010 TI - Monte Carlo study of nonuniversal wetting behavior in (2+1) dimensions. PMID- 9945011 TI - Nonexponential relaxation in spin glasses and glassy systems. PMID- 9945012 TI - Computer study of the electrical noise in high-dimensional percolating systems. PMID- 9945013 TI - Scaling in cascades of transitions. PMID- 9945014 TI - Interface at general orientation in a two-dimensional Ising model. PMID- 9945015 TI - Anharmonic vibrational modes of chemisorbed H on the Rh(001) surface. PMID- 9945017 TI - Nucleation and amorphous and crystalline growth: A dynamical model in two dimensions. PMID- 9945016 TI - Zener tunneling and localization in small conducting rings. PMID- 9945018 TI - Phase stability of ternary alloys in the four-sublattice Bragg-Williams approximation. PMID- 9945019 TI - Resistivity and transverse magnetoresistance in ultrathin films of pure bismuth. PMID- 9945020 TI - Triple-shell symmetry in alpha -(Al,Si)-Mn. PMID- 9945021 TI - Spectral momentum density of graphite from (e,2e) spectroscopy: Comparison with first-principles calculation. PMID- 9945022 TI - Analytic nearest-neighbor model for fcc metals. PMID- 9945024 TI - Crystallization of icosahedral Al86Mn PMID- 9945023 TI - Bargmann's theorem and position-dependent effective mass. PMID- 9945025 TI - Electron-phonon thermodynamic potential and magnetism of a metal. PMID- 9945026 TI - Real-space interpretation of x-ray-excited Auger-electron diffraction from Cu(001). PMID- 9945027 TI - Molecular dynamics of Rayleigh waves in Lennard-Jones crystals. PMID- 9945029 TI - Quasiperiodic packing densities. PMID- 9945028 TI - Electrical resistivity of polycrystalline niobium nitride films. PMID- 9945030 TI - Wave propagation in a one-dimensional quasiperiodic medium: Localization and intermittency. PMID- 9945031 TI - Initial growth modes of Ag on Ni(100) and Ni(111) determined by planimetry with adsorbed CO. PMID- 9945032 TI - Bonding and reconstruction of the W(001) surface. PMID- 9945033 TI - Magnetoexcitons in quasiperiodic superlattices. PMID- 9945034 TI - Self-consistent weighted-density approximation for the electron gas. I. Bulk properties. PMID- 9945035 TI - Self-consistent weighted-density approximation for the electron gas. II. The metal surface. PMID- 9945037 TI - Photoluminescence and photoconductivity measurements on band-edge offsets in strained molecular-beam-epitaxy-grown InxGa PMID- 9945036 TI - Electronic behavior of Ga2/3PS PMID- 9945038 TI - Polarons, bipolarons, and their effect on optical spectra in doped polyselenophene. PMID- 9945040 TI - Recombination in disordered semiconductors: The nearest-available-neighbor distribution. PMID- 9945039 TI - Electroreflectance and photoreflectance study of the space-charge region in semiconductors: (In-Sn-O)/InP as a model system. PMID- 9945042 TI - Allowed 3h-1e transition in semiconductor quantum wells. PMID- 9945041 TI - Continuum studies of magnetic polarons and bipolarons in antiferromagnets. PMID- 9945043 TI - Magnetooptics and excitation spectroscopy: Two efficient methods for distinguishing excitons bound to different acceptor centers in CdS. PMID- 9945045 TI - Coupled Brillouin-Raman study of direct and folded acoustic modes in GaAs-AlAs superlattices. PMID- 9945044 TI - Theory of light scattering by longitudinal-acoustic phonons in superlattices. PMID- 9945046 TI - Anomalous temperature-dependent band gaps in CuInS2 studied by surface-barrier electroreflectance. PMID- 9945047 TI - Model tunneling problems in a high magnetic field. PMID- 9945048 TI - Neutral donor-acceptor-pair recombination under a uniform electric field. PMID- 9945050 TI - Theory of exchange interactions and chemical trends in diluted magnetic semiconductors. PMID- 9945049 TI - Elastic constants and density of states of a molecular-dynamics model of amorphous silicon. PMID- 9945051 TI - Indium-doped GaAs: A very dilute alloy system. PMID- 9945052 TI - Mixing of valence subbands in GaAs/AlxGa1-xAs multiple quantum wells by uniaxial stress. PMID- 9945053 TI - Magnetoexcitons in a narrow single GaAs-Ga0.5Al0.5As quantum well grown by molecular-beam epitaxy. PMID- 9945054 TI - Effect of oxygen on the migration of the carbon interstitial defect in silicon. PMID- 9945055 TI - Lattice-simulation investigation of the migration of lithium in C6Li. PMID- 9945056 TI - High-resolution infrared study of the neutralization of silicon donors in gallium arsenide. PMID- 9945057 TI - Bremsstrahlung-isochromat study of the layered compounds InSe, TiSe2, SnSe2, SnS2, and Bi2Te3. PMID- 9945058 TI - Resonance tunneling in a periodic time-dependent external field. PMID- 9945059 TI - Mechanisms of thermal equilibration in doped amorphous silicon. PMID- 9945061 TI - Network dynamics of chalcogenide glasses. I. Germanium diselenide. PMID- 9945060 TI - X-ray photoemission spectroscopy of alkali-metal antimonide photocathodes: Valence-band spectra. PMID- 9945062 TI - Network dynamics of chalcogenide glasses. II. Silicon diselenide. PMID- 9945064 TI - High-pressure Raman study of CeO2 to 35 GPa and pressure-induced phase transformation from the fluorite structure. PMID- 9945063 TI - Interatomic radiative transition rates for the sodium fluoride crystal. PMID- 9945065 TI - Systematics of chemical and structural disorder on band-edge properties of semiconductor alloys. PMID- 9945066 TI - Experimental evidence for lattice instability of potassium at low temperatures. PMID- 9945067 TI - Field-ion-microscopy contradiction of the quasicrystal model based on twinning of a cubic crystal. PMID- 9945068 TI - Thermodynamic properties of defects in crystals calculated on the basis of the bulk elastic data. PMID- 9945069 TI - Erratum: Fourth-order gradient expansion of the fermion kinetic energy: Extra terms for nonanalytic densities PMID- 9945070 TI - Phase-formation diagram for precursors to epitaxial growth of NiSi2 on Si(111). PMID- 9945072 TI - Landauer-type formulation of quantum-Hall transport: Critical currents and narrow channels. PMID- 9945071 TI - Magnetic local-moment effects in the quasi-one-dimensional conductor Cu(triazatetrabenzporphyrinato)I. PMID- 9945073 TI - Microwave conductivity and dielectric constant of tetramethyltetrathiafulvalene salts PMID- 9945075 TI - Direct observations of the deuterium-induced surface reconstruction of the Ni(110) plane. PMID- 9945074 TI - Evidence for a covalent surface KCN species on Pd(100) from inter- atomic Auger transitions. PMID- 9945076 TI - Tunneling microscopy of 2H-MoS2: A compound semiconductor surface. PMID- 9945078 TI - Study of the single-particle and transport lifetimes in GaAs/AlxGa PMID- 9945077 TI - Structural and electronic properties of a surface alloy of Pd and Cu on Cu{001} PMID- 9945080 TI - Strain-induced conduction-band nonparabolicity of GaAs-GaAs1-xPx superlattices. PMID- 9945079 TI - Upper-subband transport in GaAs heterostructures. PMID- 9945081 TI - Luminescence from quantized exciton-polariton states in Cd1-xZnxTe/CdTe/Cd1 xZnxTe thin-layer heterostructures. PMID- 9945082 TI - Subband spacings of quasi-one-dimensional inversion channels on InSb. PMID- 9945083 TI - Quantum size effect in monolayer-doped heterostructures. PMID- 9945084 TI - Expansion of the electron-hole plasma in Si: A picosecond time-resolved Raman probe. PMID- 9945086 TI - Direct measurement of exchange as a function of separation for discrete donor acceptor pairs in ZnSe. PMID- 9945085 TI - Observation of strain in the Si(111) 7 x 7 surface. PMID- 9945087 TI - Minimal tight-binding Hamiltonian for semiconductors. PMID- 9945088 TI - Mechanism of nuclear spin-lattice relaxation in insulators at very low temperatures. PMID- 9945089 TI - Universality relationships in condensed matter: Bulk modulus and sound velocity. PMID- 9945090 TI - Concentration and temperature dependence of hydrogen vibrations along the c axis for hydrogen in yttrium: Evidence of dynamically coupled hydrogen pairs. PMID- 9945091 TI - Thermal attenuation in atom-surface scattering: A useful approximation. PMID- 9945092 TI - Systematic ab initio configuration-interaction study of alkali-metal clusters. II. Relation between electronic structure and geometry of small sodium clusters. PMID- 9945093 TI - Structure and electronic properties of Thue-Morse lattices. PMID- 9945094 TI - Extended x-ray-absorption fine-structure studies of diamond and graphite. PMID- 9945095 TI - Excimer formation as the relaxation of a nonlinear oscillator: Theory of Y states. PMID- 9945096 TI - Localization for correlated binary-alloy disorder. PMID- 9945097 TI - Growth and electronic structure of ultrathin palladium films on Al(111) and their interaction with oxygen and carbon monoxide. PMID- 9945098 TI - Elastic quantum resistance between metallic interfaces. PMID- 9945099 TI - Electronic transport properties of NiPS3. PMID- 9945100 TI - Diffusion and trapping of muons in aluminum: New experiments and comparison with Kondo theory. PMID- 9945101 TI - Density-functional theory of elastic moduli: Hard-sphere and Lennard-Jones crystals. PMID- 9945102 TI - Diffuse scattering from quasicrystals. PMID- 9945103 TI - Quantum size effect observed in ultrafine magnesium particles. PMID- 9945104 TI - Unoccupied-electronic-band structure of graphite studied by angle-resolved secondary-electron emission and inverse photoemission. PMID- 9945105 TI - Tunneling current between two nonplanar surfaces. PMID- 9945106 TI - 57Co Mossbauer study of the recovery process of electron-irradiated gold. PMID- 9945108 TI - Simultaneous measurements of resistivity and thermopower of orthorhombic TaS3 under pressure. PMID- 9945107 TI - Positive Hall effect in paramagnetic amorphous Zr-Fe. PMID- 9945109 TI - Electronic-structure and local-order study of GexSe PMID- 9945111 TI - Dipole effects and band offsets at semiconductor interfaces. PMID- 9945110 TI - Electronic structure of molecular-beam-epitaxy growth-induced defects in GaAs. PMID- 9945112 TI - Excitonic modes in a Bose-condensed electron-hole gas in the pairing approximation. PMID- 9945113 TI - Size and temperature effects on the thermoelectric power and electrical resistivity of bismuth telluride thin films. PMID- 9945115 TI - Soliton dynamics in trans-polyacetylene using the full Pariser-Parr-Pople Hamiltonian. PMID- 9945114 TI - Effect of phonon self-energy correction on hot-electron relaxation in two dimensional semiconductor systems. PMID- 9945116 TI - Phonon-assisted exciton tunneling in GaAsxP PMID- 9945118 TI - Density of states in a two-dimensional electron gas: Impurity bands and band tails. PMID- 9945117 TI - Electron-LO-phonon interaction in semiconductor double heterostructures. PMID- 9945119 TI - Donor transition energies and their line strengths in GaAs/AlxGa PMID- 9945120 TI - Raman-scattering depth profile of the structure of ion-implanted GaAs. PMID- 9945121 TI - Experimental self-energy corrections for various semiconductors determined by electron spectroscopy. PMID- 9945123 TI - Molecular-dynamics simulations of epitaxial crystal growth from the melt. I. Si(100). PMID- 9945122 TI - Gradient expansion of the exchange-energy density functional: Effect of taking limits in the wrong order. PMID- 9945124 TI - Molecular-dynamics simulations of epitaxial crystal growth from the melt. II. Si(111). PMID- 9945126 TI - Properties of thin strained Ga(As,P) layers. PMID- 9945125 TI - Preparation and melting of amorphous silicon by molecular-dynamics simulations. PMID- 9945128 TI - Correlated ground state of diamond reexamined. PMID- 9945129 TI - Oscillator strength and optical selection rule of excitons in quantum wells. PMID- 9945127 TI - Fundamental absorption edge in mixed single crystals of II-VI compounds. PMID- 9945131 TI - Evidence for differing short- and long-time decay behavior in the dynamic response of the insulating spin-glass Eu0.4Sr PMID- 9945130 TI - Normal and hot-electron magnetophonon resonance in a GaAs heterostructure. PMID- 9945132 TI - Profile structures of ultrathin periodic and nonperiodic multilayer films containing a disubstituted diacetylene by high-resolution x-ray diffraction. PMID- 9945134 TI - Neutron-scattering study of methane bilayer and trilayer films on graphite. PMID- 9945133 TI - Raman spectroscopy and theoretical modeling of BeO at high pressure. PMID- 9945135 TI - Time-differential perturbed-angular-correlation study of copper oxides. PMID- 9945136 TI - c-axis conduction in graphite intercalation compounds. PMID- 9945138 TI - K-shell electron binding energy of metallic Mg and Ca. PMID- 9945137 TI - Mechanism of Fermi-level stabilization in semiconductors. PMID- 9945139 TI - Ambipolar density and temperature profiles of an electron-hole plasma within a semiconductor slab. PMID- 9945140 TI - Intra-d excitations: Comparison between approaches for impurities in semiconductors. PMID- 9945141 TI - Functional-integral approach to the bound magnetic polaron in semimagnetic semiconductors. PMID- 9945143 TI - Discontinuous behavior of the localization properties in a finite-length incommensurate potential with weak applied electric fields. PMID- 9945142 TI - Site dependence of donor properties in ZnSe and validity of effective-mass theory. PMID- 9945144 TI - Ab initio calculations of static lattice properties for NaCl and a test of the Decker equation of state. PMID- 9945146 TI - Staging transitions in multiple-quantum-well systems. PMID- 9945145 TI - Asymmetry in the interior arachidic-acid bilayers within ultrathin multilayers fabricated via the Langmuir-Blodgett technique. PMID- 9945147 TI - Comment on "Pseudopotentials that work: From H to Pu" PMID- 9945149 TI - Metal-insulator transitions in doped silicon and germanium. PMID- 9945148 TI - Reply to "Comment on 'Pseudopotentials that work: From H to Pu' " PMID- 9945151 TI - Reply to "Comment on 'Heterojunction valence-band-discontinuity dependence on face orientation' " PMID- 9945150 TI - Comment on "Heterojunction valence-band-discontinuity dependence on face orientation" PMID- 9945152 TI - Many-body effects at the Si L2,3VV Auger line shape: The case of Ca silicides. PMID- 9945154 TI - Exact limits of the many-body local fields in a two-dimensional electron gas. PMID- 9945153 TI - Mixed valence of Sm on metal single-crystal surfaces. PMID- 9945155 TI - Fibonacci invariant and electronic properties of GaAs/Ga1-xAlxAs quasiperiodic superlattices. PMID- 9945156 TI - 5f-band width and hybridization in uranium silicides. PMID- 9945157 TI - Localization and electron-electron interaction effects in thin Bi wires and films. PMID- 9945158 TI - Hyperfine interaction between indium atoms and oxygen vacancies in stannic oxide. PMID- 9945159 TI - Depth dependence for extended x-ray-absorption fine-structure spectroscopy detected via electron yield in He and in vacuum. PMID- 9945160 TI - Nuclear-magnetic-resonance study of amorphous silicon-hydrogen-phosphorus alloys. PMID- 9945161 TI - NMR and EPR studies of the organic conductor PMID- 9945162 TI - Energy spectra of secondary electrons induced by fast ions under channeling conditions. PMID- 9945163 TI - Spin temperature applied to an inhomogeneously broadened pure quadrupolar resonance. PMID- 9945164 TI - Magnetic-flux dependence of the resistive transition in a square Josephson junction array. PMID- 9945166 TI - Pseudo-Coulomb potential in singlet superconductivity. PMID- 9945165 TI - Transition to superfluid turbulence in two-fluid flow of He II. PMID- 9945167 TI - Theory of the photon-drag effect in a two-dimensional electron gas. PMID- 9945168 TI - Lifetime of metastable voltage states of superconducting tunnel junctions. PMID- 9945169 TI - Impurity states in liquid-helium films. PMID- 9945170 TI - Perpendicular upper critical field and critical temperature of superconducting interphase-normal-metal multilayers. PMID- 9945171 TI - Solid-fluid phase transition of quantum hard spheres at finite temperatures. PMID- 9945172 TI - Realistic treatment of the self-energy formalism in heavy-fermion metals: Application to superconducting phases of CeRu2 and CeOs2. PMID- 9945173 TI - Pressure-induced noncrystalline phase of LiKSO4. PMID- 9945174 TI - Neutron scattering studies of the magnetic structure of cupric oxide. PMID- 9945175 TI - Penetration of a magnetic field in a very strong coupling superconductor. PMID- 9945176 TI - Lattice instability and soft phonons in single-crystal La2-xSrxCuO4. PMID- 9945177 TI - Electronic structure of Cu-O chains in the high-Tc superconductor YBa2Cu3O7. PMID- 9945178 TI - Electronic structure of Bi2Sr PMID- 9945179 TI - Microscopic model of hybrid pairing: A common approach to heavy-fermion and high Tc superconductivity. PMID- 9945180 TI - Core-level shifts on cleaved YBa2Cu3O7-x(001) surfaces observed in angle-resolved photoemission. PMID- 9945181 TI - Pairing interaction mediated by the Cu-O charge-transfer oscillations associated with LO phonons in oxide superconductors and their high-Tc superconductivity. PMID- 9945182 TI - Structures of the superconducting oxides Tl2Ba2CuO6 and Bi2Sr2CuO6. PMID- 9945184 TI - Transport properties, phase transition, and recovery near 200 K of proton irradiated YBa2Cu3O7 thin films. PMID- 9945183 TI - Disruption, segregation, and passivation for Pd and noble-metal overlayers on YBa2Cu3O6.9. PMID- 9945185 TI - Multiple-scattering analysis of K-edge x-ray-absorption near-edge spectrum of YBa2Cu PMID- 9945186 TI - Anisotropic superconducting properties of Ba2YCu PMID- 9945187 TI - Crystal-field interaction in the GdxEu1-xBa2Cu3OR7- delta superconductors. PMID- 9945189 TI - Superconductivity on a YBa2Cu PMID- 9945188 TI - Possibility of an increase in density of states to explain the Tc change from La2 xSrxCuO4 to YBa2Cu3O7. PMID- 9945190 TI - Raman study of the effect of oxygen stoichiometry on the phonon spectrum of the high-Tc superconductor YBa2Cu PMID- 9945191 TI - Role of long-range Coulomb interactions in granular superconductors. PMID- 9945192 TI - Upper critical magnetic field of superconductors with a dielectric gap on the Fermi-surface sections. PMID- 9945194 TI - Functional integral theories of low-dimensional quantum Heisenberg models. PMID- 9945193 TI - Critical exponents at the three-loop level from stochastic continuum regularization. PMID- 9945195 TI - Singular dynamic scaling on fractal lattices. PMID- 9945196 TI - Thermal conductivity of cerium compounds. PMID- 9945197 TI - From quasicrystals to icosahedral glass. PMID- 9945198 TI - Neutron diffraction study of the magnetic (H,T) phase diagrams of EuAs3 and Eu(As1-xPx)3. PMID- 9945199 TI - Two-dimensional crystalline electrons in the Hall configuration. PMID- 9945200 TI - Phase transitions and phase diagrams of K and Cs overlayers on a reconstructed and unreconstructed Cu(110) surface. PMID- 9945201 TI - Nonequilibrium dynamics of spin glasses. PMID- 9945202 TI - Equilibrium behavior of the spin-glass ordered phase. PMID- 9945203 TI - Random fields and orientational order in Rb(CN)xBr1-x mixed crystals: A study of static-shear elasticity. PMID- 9945204 TI - Magnetism in bcc and fcc manganese. PMID- 9945206 TI - Low-temperature specific heat in ferroelectric (Pb,Ba)5Ge3O11 crystals. PMID- 9945205 TI - Monte Carlo study of the symmetric Anderson-impurity model. PMID- 9945207 TI - Generalized moment expansion of dynamic correlation functions in finite Ising systems. PMID- 9945209 TI - Finite-temperature theory of local-environment effects in Fe-Ni alloys. PMID- 9945208 TI - Wetting in fcc Ising antiferromagnets and binary alloys. II. A Monte Carlo and renormalization-group study. PMID- 9945210 TI - Analysis of a dynamic renormalization-group technique. PMID- 9945211 TI - Diffusion and spin correlation in fractal percolation clusters. PMID- 9945212 TI - Phase transition in the Ising ferromagnetic model with fixed spins. PMID- 9945213 TI - Modified Migdal-Kadanoff renormalization for the spin-(1/2 anisotropic Heisenberg model. PMID- 9945214 TI - Rotationally invariant elasticity in a planar fractal network. PMID- 9945215 TI - Field theory for growth kinetics. PMID- 9945216 TI - Spin dynamics and the Haldane gap in the spin-1 quasi-one-dimensional antiferromagnet CsNiCl3. PMID- 9945217 TI - Compositional and orientational ordering of CO-Ar and N2-Ar on graphite. PMID- 9945218 TI - Universal finite-size-scaling amplitudes of the Potts model on a torus. PMID- 9945219 TI - Observation of itinerant-electron effects on the magnetic excitations of iron. PMID- 9945221 TI - Thermal sine-Gordon system in the presence of different types of dissipation. PMID- 9945220 TI - Wavelength dependence of cells of finite depth in directional solidification. PMID- 9945222 TI - Direct observation of relaxation modes in KNbO3 and BaTiO3 using inelastic light scattering. PMID- 9945223 TI - Dielectric properties of LiTaO3. PMID- 9945224 TI - Vibration of a Hubbard chain and its specific heat. PMID- 9945226 TI - Sequences of accumulation points in the phase diagram of the Frenkel-Kontorova model with a modified potential. PMID- 9945225 TI - Crystal-field analysis of the magnetization process in a series of Nd2Fe14B-type compounds. PMID- 9945227 TI - Double-chain approximation for the Ising model. PMID- 9945228 TI - Monte Carlo simulations of the periodic Anderson model on a square lattice. PMID- 9945229 TI - Role of three-body correlations in recombination of spin-polarized atomic hydrogen. PMID- 9945230 TI - Coherent states as solutions of the anisotropic Heisenberg antiferromagnetic chain. PMID- 9945231 TI - Low-temperature incommensurate-commensurate phase sequence of (C3H7ND3)2MnCl4. PMID- 9945233 TI - Green's-function theory of ferroelectric phase transitions in hydrogen-bonded triglycine sulfate with the pseudospin-lattice coupled-mode model: A unified theory of structural phase transitions. I. Static and dynamic properties. PMID- 9945232 TI - Mechanism for c-axis conduction in graphite intercalation compounds. PMID- 9945234 TI - Green's-function theory of ferroelectric phase transitions in hydrogen-bonded triglycine sulfate with the pseudospin-lattice coupled-mode model: A unified theory of structural phase transitions. II. Nonlinear properties. PMID- 9945236 TI - Interaction mechanisms contributing to spin-glass freezing in Au-Cu-Mn alloys. PMID- 9945235 TI - Strength of disordered solids. PMID- 9945238 TI - Family of diamond-type hierarchical lattices. PMID- 9945237 TI - Cluster-expansion method for the infinite-range quantum transverse Ising spin glass model. PMID- 9945239 TI - Proximity-effect bilayers with magnetic impurities: The Abrikosov-Gor'kov limit. PMID- 9945241 TI - Thermodynamic measurements of the multiple-exchange frequencies in bcc 3He. PMID- 9945240 TI - Vicinage effect in inner-shell ionization. PMID- 9945242 TI - Superconducting-normal phase boundary of a random network in magnetic fields. PMID- 9945244 TI - Staircase superconducting structure and oxygen intercalation in YBa2Cu3O7- delta single crystals. PMID- 9945243 TI - SU(2) gauge symmetry of the large-U limit of the Hubbard model. PMID- 9945245 TI - Raman scattering from the Bi2Sr PMID- 9945246 TI - Superconductivity in bismuth-strontium-copper oxides. PMID- 9945247 TI - Crystallographic, thermodynamic, and transport properties of the Bi2Sr3 xCaxCu2O8+ delta superconductor. PMID- 9945248 TI - Orientation-dependent x-ray-absorption near-edge studies of high-Tc superconductors. PMID- 9945249 TI - Superconducting properties of high-Tc Bi-Sr-Ca-Cu-O thin films. PMID- 9945250 TI - Polarized-neutron study of the YBa2Cu3O7 system: Granular versus bulk superconductivity. PMID- 9945251 TI - Oxygen diffusion in superconducting YBa2Cu3O7- delta oxides in ambient helium and oxygen. PMID- 9945252 TI - Electrical transport and superconductivity in a Au-YBa2Cu3O7 percolation system. PMID- 9945253 TI - Anomalous low-frequency vibrational dynamics in YBa2Cu3O7+ epsilon by micro-Raman spectroscopy. PMID- 9945254 TI - Critical analysis of a reported anomalous low-temperature susceptibility of solid 3He at high molar volume. PMID- 9945255 TI - Direct neutron observation of a single-q incommensurate phase of quartz at zero stress. PMID- 9945256 TI - Conserved-phase field system: Implications for kinetic undercooling. PMID- 9945258 TI - Field-induced transverse-sine-wave-to-longitudinal-sine-wave transition in EuAs3. PMID- 9945257 TI - Magnetic susceptibility of expanded fluid alkali metals. PMID- 9945259 TI - Power law and the viscosity of supercooled glass-forming metallic systems. PMID- 9945260 TI - Reentrant behavior of an in-plane antiferromagnet in a magnetic field. PMID- 9945261 TI - Universal equation of state. PMID- 9945262 TI - Freezing of the hard-sphere liquid. PMID- 9945263 TI - Acoustic plasmons in a two-dimensional, two-component electron liquid. PMID- 9945264 TI - Low-frequency noises of Josephson-junction arrays in transverse magnetic fields. PMID- 9945265 TI - Screening of a point charge in semiconductors and insulators. PMID- 9945267 TI - Comment on "Critical cutting forces between flux vortices in a type-II superconductor" PMID- 9945266 TI - Response to "Screening of a point charge in semiconductors and insulators" PMID- 9945269 TI - Superconductivity of itinerant electrons coupled to spin chains. PMID- 9945268 TI - Erratum: Self-consisteng large-N expansion for normal-State properties of dilute magnetic alloys PMID- 9945270 TI - Effect of valence mixing on multiplet structures in core photoabsorption spectra for Ce compounds. PMID- 9945271 TI - Properties of Y-Ba-Cu-O thin films with ordered defect structure: Y2Ba4Cu8O20-x. PMID- 9945272 TI - Evidence for the dependence of the magnetic ordering on the oxygen occupancy in the high-Tc superconductor GdBa2Cu PMID- 9945273 TI - Asymmetry in the normal-metal to high-Tc superconductor tunnel junction. PMID- 9945274 TI - Hall coefficient and oxygen stoichiometry in YBa2Cu3O7- delta ceramics at elevated temperatures. PMID- 9945275 TI - Temperature dependence of the positron annihilation lifetime in single-crystal YBa2Cu PMID- 9945276 TI - Freezing of spin and charge in La2-xSrx PMID- 9945277 TI - Effect of oxygen on the filamentary superconductivity of the La2-xCuO4- delta system. PMID- 9945278 TI - Microstructure and properties of the ~90-K superconductor Bi2Sr3-xCaxCu2O8+ delta. PMID- 9945279 TI - High-resolution electron-energy-loss spectroscopy of YBa2Cu PMID- 9945280 TI - Hole dynamics in the two-dimensional strong-coupling Hubbard Hamiltonian. PMID- 9945281 TI - Oxygen-deficiency-induced localized optical excitations in YBa2Cu PMID- 9945283 TI - Electron-phonon coupling in the two-dimensional Hubbard model: A Monte Carlo study. PMID- 9945282 TI - Anharmonic thermal motion in the 93-K superconductor Ba2YCu PMID- 9945284 TI - Photoemission study of the new high-temperature superconductor Bi-Ca-Sr-Cu-O. PMID- 9945285 TI - Effect of magnetic fields on the specific heat of a YBa2Cu3O7- delta single crystal near Tc. PMID- 9945286 TI - Anomalous variation of the c lattice parameter of a sample of YBa2Cu3O7- delta through the superconducting transition. PMID- 9945288 TI - Nature of the valence photoemission features of single-crystal YBa2Cu PMID- 9945287 TI - Structure and physical properties of single crystals of the 84-K superconductor Bi2.2Sr2Ca0.8Cu2O8+ delta. PMID- 9945289 TI - Magnetic defects in La2-xSrx PMID- 9945290 TI - Antisymmetric exchange and its influence on the magnetic structure and conductivity of La2CuO4. PMID- 9945291 TI - Systematic variation of magnetic-field penetration depth in high-Tc superconductors studied by muon-spin relaxation. PMID- 9945292 TI - Electronic structure studies of La2CuO PMID- 9945294 TI - Inelastic electron scattering in the high-Tc compound YBa2Cu PMID- 9945293 TI - Evidence for anisotropic excitonlike enhancement of the Raman scattering from La2CuO PMID- 9945295 TI - New theory of strong-coupling superconductors and high-temperature superconductivity of metallic oxides. PMID- 9945296 TI - Linear temperature dependence of the resistivity in the new superconductors. PMID- 9945297 TI - Superconductivity in correlated wave functions. PMID- 9945298 TI - Superconductivity in the dilute electron gas. PMID- 9945299 TI - Shubnikov-de Haas effect and the Fermi surface in an ambient-pressure organic superconductor PMID- 9945301 TI - Ising model with short-range correlated dilution. PMID- 9945300 TI - New universality class for gelation in a system with particle breakup. PMID- 9945302 TI - Wavelength dependence of static intensity correlation functions. PMID- 9945303 TI - Nonlocal percolation in an antiferromagnetic Potts model. PMID- 9945304 TI - Correlations between the kinetics of zinc electrodeposition and the fractal properties of the deposits. PMID- 9945305 TI - Spin-density-wave transitions in the many-component limit. PMID- 9945306 TI - Channeling effects on positron transmission through thin crystals. PMID- 9945307 TI - Influence of alternating magnetic fields on 67Zn Mossbauer resonance in ZnO. PMID- 9945308 TI - EPR and optical absorption of a self-trapped hole in Rb2ZnCl PMID- 9945309 TI - Sputtering transport theory: The mean energy. PMID- 9945310 TI - Neutron irradiation of heavy-fermion superconductors. PMID- 9945311 TI - Electric-field-induced memory effects in granular films. PMID- 9945312 TI - Spin waves in 3He-4He solutions. PMID- 9945313 TI - UPt5-xAux: A heavy-fermion system with a selectable m. PMID- 9945314 TI - Two-magnon Raman scattering in (La1-xSrx PMID- 9945315 TI - Intensities of zero-phonon Tv(0) and Vv(0) single transitions and Sv(0)+Rv'(0) and Sv(0)+Tv'(0) double transitions in solid HD. PMID- 9945316 TI - Exact behavior of the density and spin susceptibilities of a Fermi liquid for large wave vectors: Derivation from diagrammatic many-body theory. PMID- 9945317 TI - Theory of nonlinear quantum tunneling resistance in one-dimensional disordered systems. PMID- 9945318 TI - Valence charge fluctuations in YBa2Cu3O7- delta from core-level spectroscopies. PMID- 9945319 TI - Electronic structure of the new high-Tc superconductors Tl2Ba2CuO6, Tl2Ba2Cu2O8, Tl2Ba2Ca2Cu3O10, and Tl2BaCa3Cu4O12. PMID- 9945320 TI - Photoinduced self-localized structural distortions in YBa2Cu3O7- delta. PMID- 9945321 TI - X-ray absorption study of the O 2p hole concentration dependence on O stoichiometry in YBa2Cu3Ox. PMID- 9945322 TI - Remanent moment of high-temperature superconductors: Implications for flux pinning and glassy models. PMID- 9945324 TI - Theory of high-Tc superconductors within an Anderson lattice model. PMID- 9945325 TI - Model family of high-temperature superconductors: TlmCan-1Ba2CunO2(n+1)+m (m=1,2; n=1,2,3). PMID- 9945323 TI - Electronic structures of the YBa2Cu3O7-x surface and its modification by sputtering and adatoms of Ti and Cu. PMID- 9945326 TI - Observation of a narrow superconducting transition at 6 GHz in crystals of YBa2Cu3O7. PMID- 9945327 TI - Oxygen intercalation in the perovskite superconductor YBa2Cu3O6+x. PMID- 9945329 TI - d-wave superconducting condensation in the spin-density-wave background. PMID- 9945328 TI - Observation of triplet hole pairs and glassy spin waves in La2-x-zSrxCuO4-y by electron spin resonance. PMID- 9945330 TI - Lattice vibrational studies of superconducting YBa2Cu3O7 by polarized extended x ray-absorption fine-structure measurements. PMID- 9945331 TI - Neutron-powder-diffraction study of nuclear and magnetic structure in YBa2Cu3 xCoxO7+y with x=0.84 and y=0.32. PMID- 9945332 TI - Calculation of the isotope effect in La2-xMxCuO4 and YBa2Cu3O7-x. PMID- 9945333 TI - Insufficiency of O and Cu holes for oxide superconductivity: X-ray absorption spectroscopy. PMID- 9945334 TI - Atomistic model of orthorhombic YBa2Cu PMID- 9945335 TI - Ordering of O vacancies in YBa2Cu PMID- 9945336 TI - Superstructure along the c axis in YBa2Cu3O7-x single crystals having Tc=92 K. PMID- 9945337 TI - Antiferromangetic spin correlations in insulating, metallic, and superconducting La2-xSrx PMID- 9945339 TI - Doping dependence of antiferromagnetic correlations in high-temperature superconductors. PMID- 9945338 TI - Structure refinements of superconducting Tl2Ba2CaCu2O8 and Tl2Ba2Cu3O10 from neutron diffraction data. PMID- 9945340 TI - Neutron-scattering study of the transition from antiferromagnetic to weak ferromagnetic order in La2CuO PMID- 9945341 TI - Lower critical field of an anisotropic extreme type-II superconductor. PMID- 9945342 TI - Calculated effective Hamiltonian for La2CuO4 and solution in the impurity Anderson approximation. PMID- 9945343 TI - Site-selective doping and superconductivity in (La1-yPry)(Ba2-xLax)Cu3O7+ delta. PMID- 9945344 TI - Magnetic order and superconductivity in RBa2Cu3Oz. PMID- 9945346 TI - Exact solution of a lattice band problem related to an exactly soluble many-body problem: The missing-states problem. PMID- 9945345 TI - Infrared studies of ab-plane oriented oxide superconductors. PMID- 9945348 TI - Effective-medium theory of long-wavelength spin waves in magnetic superlattices. PMID- 9945347 TI - Shape crossover in the correlation function of isotropic ferromagnets above Tc. PMID- 9945349 TI - Impossibility of spontaneous current in equilibrium. PMID- 9945350 TI - Hamiltonian equations for multiple-collective-variable theories of nonlinear Klein-Gordon equations: A projection-operator approach. PMID- 9945351 TI - Collapse transition of branched polymers with a tunable number of loops. PMID- 9945353 TI - Three-stage melting in two dimensions initiated by the formation of grain boundaries: A molecular-dynamics study. PMID- 9945352 TI - Finite-size scaling analysis of the S=1 Ising model on the triangular lattice. PMID- 9945354 TI - Nonlinear density-functional approach to the crystallization of the classical one component plasma. PMID- 9945355 TI - Simulated equilibrium and nonequilibrium interfaces in a lattice model. PMID- 9945356 TI - Continuous-time random walks on a long-range hierarchical model. PMID- 9945357 TI - Extraordinary Hall effect in Kondo-type systems: Contributions from anomalous velocity. PMID- 9945358 TI - Monte Carlo simulation of adiabatic cooling and nuclear magnetism. PMID- 9945359 TI - Neutron-scattering spectra of noncubic cerium Kondo compounds. PMID- 9945360 TI - Resonating-valence-bond states with antiferromagnetic long-range order. PMID- 9945362 TI - Morphology of micromagnetics. PMID- 9945361 TI - Electronic structure, dynamic susceptibility, and Neel temperature of the heavy fermion magnet UCu5. PMID- 9945363 TI - Ground-state properties of generalized Heisenberg chains with composite spin. PMID- 9945365 TI - Monte Carlo investigation of the resonating-valence-bond ground state and a lattice statistical model. PMID- 9945364 TI - Ferromagnetic resonance studies of exchange-biased Permalloy thin films. PMID- 9945366 TI - Ground state of the two-dimensional antiferromagnetic Heisenberg model and the resonating-valence-bond states. PMID- 9945367 TI - Monte Carlo and mean-field study of antiferromagnetic ordering in cupric oxides. PMID- 9945368 TI - Stability of networks under tension and pressure. PMID- 9945369 TI - Instabilities in deeply supersaturated systems. PMID- 9945370 TI - Magnetic phase diagram of NiCl2 PMID- 9945371 TI - Scaling and domain growth in a model-C system. PMID- 9945372 TI - Weakly diluted n >= 2 Ising antiferromagnets: Loss of long-range order and crossover effects. PMID- 9945373 TI - Correlation functions for interacting fermions in the Gutzwiller ansatz. PMID- 9945375 TI - Magnetization and correlation length of the easy-plane ferromagnetic chain: Numerical analysis and application to (C6H PMID- 9945374 TI - Variational approach to finite-temperature magnetism in the degenerate-band Hubbard model. PMID- 9945377 TI - Spin fluctuations in the temperature-induced paramagnet FeSi. PMID- 9945376 TI - Stoner model of ferromagnetism and total-energy band theory. PMID- 9945378 TI - Lattice theory of surface melting. PMID- 9945380 TI - New types of reentrant phase transitions in the singlet-triplet model of antiferromagnets. PMID- 9945379 TI - Theory of the soliton-induced phase transition in quasi-one-dimensional magnets. PMID- 9945382 TI - Random local anisotropy in spin glasses. PMID- 9945381 TI - Variational ground state for the periodic Anderson model with an indirect hybridization. II. The Kondo-type singlet state compared with the magnetic state. PMID- 9945383 TI - Measurement of the oxygen content in high-Tc superconductors: Enhanced resonant ion-scattering analysis. PMID- 9945384 TI - Ordering phenomena in the tetragonal superconductor CaBaLaCu3O7- delta. PMID- 9945385 TI - Field-induced transitions in Y2Cu2O5. PMID- 9945386 TI - Hall effect of the high-Tc superconducting oxides Bi-Ca-Sr-Cu-O and Tl2Ca2Ba2Cu3Ox. PMID- 9945387 TI - rf surface resistance of Y-Ba-Cu-O thin films. PMID- 9945388 TI - Microwave surface resistance of bulk YBa2Cu PMID- 9945389 TI - Temperature dependence of the lattice parameters in the 30-K superconductor Ba0.6K0.4BiO3. PMID- 9945391 TI - Theory of high-Tc superconductors within a realistic Anderson lattice model. PMID- 9945390 TI - Millimeter-wave complex-conductivity measurements of Bi-Ca-Sr-Cu-O superconducting thin films. PMID- 9945392 TI - Exact mean-field solution of the two-particle resonance model of high-Tc superconductivity. PMID- 9945393 TI - Low-temperature specific heat of La1.85Sr0.15CuO4 and La2CuO4. PMID- 9945394 TI - Angular dependence of the magnetic-field-induced resistive transition in single crystal Bi2.2Sr2Ca0.8 Cu2O8+ delta. PMID- 9945395 TI - Uniaxial superconducting particle in intermediate magnetic fields. PMID- 9945397 TI - Pairing of holes in the spin liquid: Possible application to the high-temperature superconductors. PMID- 9945396 TI - Photoemission from single-crystalline Bi-Sr-Ca-Cu-O. PMID- 9945398 TI - Effects of inelastic electron scattering on properties of high-temperature superconductors. PMID- 9945399 TI - Statistical mechanics of CuO2 plane in the presence of localized holes. PMID- 9945400 TI - Thermoelectric power of the Tl-Ca-Ba-Cu-O superconductor. PMID- 9945401 TI - Low-temperature specific heat of PdPb2. PMID- 9945402 TI - Polytypoid structure of Pb-modified Bi-Ca-Sr-Cu-O superconductor. PMID- 9945403 TI - Superconductivity in the Tl-Sr-Ca-Cu-O system. PMID- 9945404 TI - Ultrasonic evidence for a structural phase transition at 220 K in YBa2Cu3O7- delta. PMID- 9945405 TI - Orthorhombic-tetragonal phase transition in LaBa2Cu3O7-y with zero resistance at 92 K. PMID- 9945406 TI - Effect of Ga addition to YBa2Cu3O7. PMID- 9945408 TI - Quasiperiodic dynamics for a generalized third-order Fibonacci series. PMID- 9945407 TI - Effect of oxygen distribution on the resistivity in YBa2Cu3O7- delta oxides (0 <= delta <0.8). PMID- 9945409 TI - Phase transitions in the random Gaussian model. PMID- 9945410 TI - Observation of a time-dependent spatial correlation length in a metallic spin glass. PMID- 9945411 TI - Magnetic field dependence of the resistivity and susceptibility of the above-100 K Bi-Sr-Ca-Cu superconductor. PMID- 9945412 TI - Effect of pressure on optical excitations in semiconducting MBa2Cu3O6 (M=Y,Sm,Gd). PMID- 9945414 TI - Exciton-phonon interaction in one dimension: Half-filled-band sector. PMID- 9945413 TI - New criticality in quantum models with pair interactions decaying as a power law. PMID- 9945416 TI - Erratum: Kondo effects versus indirect exchange in the two-impurity Anderson model: A Monte Carlo study PMID- 9945415 TI - Comment on "Random-field Ising model as a dynamical system" PMID- 9945417 TI - Electron-phonon interactions in energetic displacement cascades. PMID- 9945419 TI - Granular superconductivity in R1Ba PMID- 9945418 TI - Observation of crystal twinning of LaF3 with Raman heterodyne detection of NMR in Pr3+:LaF3. PMID- 9945420 TI - Oxygen intercalation homogeneity and electrical transport in superconducting Ba2YCu3O7- delta crystals. PMID- 9945421 TI - Light-scattering study of the superconducting energy gap in YBa2Cu3O7 single crystals. PMID- 9945422 TI - Anomalous in-plane paraconductivity in single-crystal YBa2Cu3O7. PMID- 9945423 TI - Hall effect in the heavy-fermion compound CePtSi. PMID- 9945424 TI - Occupied electronic states of single-crystal Bi2Ca1+xSr2+xCu2O8+y. PMID- 9945425 TI - Anomalous structural phase transition in stoichiometric La2NiO4. PMID- 9945426 TI - Electronic structure of Bi-Ca-Sr-Cu-O superconductors studied by photoelectron spectroscopy. PMID- 9945428 TI - Anisotropic thermopower in single crystals of the high-Tc superconductor YBa2Cu3O7. PMID- 9945427 TI - Broader perspective on the high-temperature superconduct- ing YBa2Cu3Oy system: The real role of the oxygen content. PMID- 9945429 TI - Magnetic penetration depth and specific heat of the paired-boson superconductor. PMID- 9945430 TI - Bi4Sr3Ca3Cu4O16 galss and superconducting glass ceramics. PMID- 9945431 TI - Magnetization profile near a wall in the planar Ising ferromagnet. PMID- 9945432 TI - Elastic properties of three-dimensional percolation networks with stretching and bond-bending forces. PMID- 9945433 TI - Mode-locking phase diagram in sliding-charge-density-wave conductors. PMID- 9945434 TI - Absence of the Hopf invariant in the long-wavelength action of two-dimensional quantum antiferromagnets. PMID- 9945435 TI - Kinetics of spinodal decomposition in one dimension. PMID- 9945436 TI - New approach to strongly correlated systems: 1/N expansions without slave bosons. PMID- 9945437 TI - Novel mechanism for superconductivity in the resonating-valence-bond ground state. PMID- 9945438 TI - Symmetry of the 3d9 ligand hole induced by doping in YBa2Cu PMID- 9945439 TI - New anelastic relaxation effect in Y-Ba-Cu-O at low temperature: A Snoek-type peak due to oxygen diffusion. PMID- 9945441 TI - Dynamical crossover to dipolar behavior in isotropic ferromagnets at and above Tc. PMID- 9945440 TI - Frequency dependence of the ac susceptibility in a Y-Ba-Cu-O crystal: A reinterpretation of Hc2. PMID- 9945442 TI - Simulation of dielectric failure by means of resistor-diode random lattices. PMID- 9945443 TI - Topological terms in one- and two-dimensional quantum Heisenberg antiferromagnets. PMID- 9945444 TI - Micropolar elastic percolation: The superelastic problem. PMID- 9945446 TI - Dielectric investigation of the sliding charge-density wave in Tl0.3MoO PMID- 9945445 TI - Stretched-exponential relaxation of birefringence in a critical binary mixture. PMID- 9945447 TI - Light-diffracted intensities from very deep gratings. PMID- 9945448 TI - Local-field method for resistivity and electromigration in metallic microstructures: Application to thin films. PMID- 9945449 TI - Structure determination of the (1 x 2) and (1 x 3) reconstructions of Pt(110) by low-energy electron diffraction. PMID- 9945450 TI - Local elastic constants for the Al(001) surface. PMID- 9945451 TI - Computer simulations of localization and quantum transport in a three-dimensional topologically disordered system. PMID- 9945452 TI - Absolute x-ray reflectivity study of the Au(100) surface. PMID- 9945453 TI - Atomic and electronic structure of crystalline and amorphous alloys. I. Calcium magnesium compounds. PMID- 9945454 TI - Atomic and electronic structure of crystalline and amorphous alloys. II. Strong electronic bonding effects in Ca-Al compounds. PMID- 9945455 TI - Structural studies of amorphous titanium diboride thin films by extended x-ray absorption fine-structure and extended electron-energy-loss fine-structure techniques. PMID- 9945457 TI - Angle-resolved photoemission study of the hydrogen-adsorbed Cr(110) surface at 80 K. PMID- 9945458 TI - Tunneling current density within Tersoff and Hamann's theory of the scanning tunneling microscope. PMID- 9945456 TI - Angle-resolved photoemission study of oxygen-adsorbed Cr(110). PMID- 9945459 TI - Lattice dynamics of CePd3. PMID- 9945460 TI - Lattice vibrational spectrum and possible existence of localized modes of the two dimensional Penrose lattice. PMID- 9945462 TI - Roughening transition on Cu(113): A quantitative analysis of new experimental results. PMID- 9945461 TI - Reversible faceting of the copper (110) surface: X-ray Fresnel reflectivity. PMID- 9945463 TI - Band dispersions of Ag(111) monolayers on various substrates. PMID- 9945465 TI - Phonon spectra and isothermal elastic constants of transition metals: A dynamical treatment. PMID- 9945464 TI - Second-harmonic generation with surface plasmons from a silvered quartz grating. PMID- 9945466 TI - Inhomogeneity expansion for the incommensurate charge-density-wave system. PMID- 9945467 TI - Atomic-layer by atomic-layer compositional depth profiling: Surface segregation and impurity cosegregation of Pt-Rh and Pt-Ru alloys. PMID- 9945468 TI - Specific-heat and transport properties of alloys exhibiting quasicrystalline and crystalline order. PMID- 9945469 TI - Experimental band structure of Cu3Au. PMID- 9945471 TI - Interaction of hydrogen and deuterium with CoTi surfaces. PMID- 9945470 TI - Observation of a surface state in overlayers of Au on Pt{001} PMID- 9945472 TI - Topological and thermal disorder in amorphous iron. PMID- 9945473 TI - Fluctuations in the optical spectra of disordered microstructures due to quantum interference effects. PMID- 9945474 TI - Charge-trapping model of metastability in doped hydrogenated amorphous silicon. PMID- 9945476 TI - Epitaxial growth and band bending of n- and p-type Ge on GaAs(001). PMID- 9945475 TI - Large interfacial charge density in unstrained GaAs-AlAs(111) superlattices. PMID- 9945477 TI - Determination of the density of states of the conduction-band tail in hydrogenated amorphous silicon. PMID- 9945479 TI - Bond-centered interstitial hydrogen in silicon: Semiempirical electronic structure calculations. PMID- 9945478 TI - Structural studies of argon-sputtered amorphous carbon films by means of extended x-ray-absorption fine structure. PMID- 9945481 TI - Effect of buffer-layer composition on new optical transitions in Si/Ge short period superlattices. PMID- 9945480 TI - GW approach to the calculation of electron self-energies in semiconductors. PMID- 9945482 TI - Chemical trend in silicide electronic structure and Schottky-barrier heights of silicide-silicon interfaces. PMID- 9945484 TI - Soft-x-ray photoemission study of chemisorption and Fermi-level pinning at the Cs/GaAs(110) and K/GaAs(110) interfaces. PMID- 9945483 TI - Asymmetric conductance and coherence effects in mesoscopic Si metal-oxide semiconductor field-effect transistors. PMID- 9945485 TI - Phonon radiative heat transfer and surface scattering. PMID- 9945486 TI - Effect of uniaxial stress on the electron spin resonance in zinc-blende semiconductors. PMID- 9945487 TI - Zeeman splitting of exciton and magnetization in Cd1-xMnxTe: Anomalous behavior at high x. PMID- 9945488 TI - Transient oscillations and dynamic Stark effect in semiconductors. PMID- 9945490 TI - Magnetophonon-resonance theory of the two-dimensional electron gas in AlxGa1 xAs/GaAs single heterostructures. PMID- 9945489 TI - Transient oscillations in the vicinity of excitons and in the band of semiconductors. PMID- 9945491 TI - Trapping of carriers in single quantum wells with different configurations of the confinement layers. PMID- 9945492 TI - First-principles study of the atomic reconstructions and energies of Ga- and As stabilized GaAs(100) surfaces. PMID- 9945493 TI - Periodic superstructures in tetrahedrally bonded homopolymers. PMID- 9945494 TI - Kinetic and hydrodynamic description of the electron-acoustic-phonon system in a double heterostructure. PMID- 9945496 TI - Optical-phonon modes in superlattices. PMID- 9945495 TI - Distribution of occupied near-surface band-gap states in a-Si:H. PMID- 9945497 TI - Raman and infrared phonon piezospectroscopy in InP. PMID- 9945498 TI - Analytical treatment of band-gap underestimates in the local-density approximation. PMID- 9945499 TI - Acoustic-wave transmission in semiconductor superlattices. PMID- 9945500 TI - Transition-metal impurities in semiconductors and heterojunction band lineups. PMID- 9945501 TI - Band offsets and lattice-mismatch effects in strained-layer CdTe/ZnTe superlattices. PMID- 9945502 TI - Trapping of gas mixtures by amorphous water ice. AB - Our studies on gas trapping in amorphous water ice at 24-100 K were extended, by using mixtures of CH4, CO, N2, and Ar, rather than single gases. In 1:1 gas:(water vapor) mixtures, the competition among these gases on the available sites in the ice showed that the trapping capacity for the various gases is determined not only by the structure and dynamics of the ice, but is also influenced by the gas itself. Whereas at 24-35 K all four gases are trapped in the ice indiscriminantly, at 50-75 K there is a clear enhancement, in the order of CH4 > CO > N2 > or approximately Ar. This order is influenced by the gas water interaction energy, the size of the trapped gas atom or molecule, the type of clathrate-hydrate formed (I or II) and, possibly, other factors. It seems that the gas can be trapped in the amorphous ice in several different locations, each being affected in a different way by the deposition temperature and gas composition. Once a gas atom or molecule is trapped in a specific location, it is predestined to emerge in one of eight different temperature ranges, which are associated with changes in the ice. The experimentally observed enhancements, together with the findings on the gas composition of comet Halley, might enable an estimation of the gas composition in the region of comet formation. PMID- 9945504 TI - Interaction of H and D with the (001) surfaces of LiF and NaCl. PMID- 9945503 TI - High-pressure x-ray diffraction study of CeO2 to 70 GPa and pressure-induced phase transformation from the fluorite structure. PMID- 9945505 TI - Diffusion and isotope effects in the diffusion of homovalent cations in cesium iodide. PMID- 9945506 TI - Fourier-transform spectroscopy in dye-doped polymers using the femtosecond accumulated photon echo. PMID- 9945507 TI - Negative magnetoresistance in some dimethyltrimethylene-tetraselenafulvalenium salts: A signature of weak-localization effects. PMID- 9945508 TI - 4f-derived photoemission and 4f-ligand hybridization in light rare-earth halides. PMID- 9945509 TI - Electric field dependence of exciton transition energies in GaAs-AlxGa PMID- 9945510 TI - Analytical solution for persistent-photoconductivity relaxation in layered semiconductors. PMID- 9945511 TI - Electrical transport properties of the aluminum-ruthenium icosahedral phase. PMID- 9945512 TI - Anomalous behavior of the Ni bonding strength in some LaNi5-xAlx PMID- 9945513 TI - New icosahedral phases in Ti-transition-metal alloys. PMID- 9945514 TI - Photoemission from small metal spheres: A model calculation using an enhanced three-step model. PMID- 9945515 TI - Structural stability of rhenium as a function of lattice compression: Theory. PMID- 9945516 TI - Surface-atom core-level shifts of W(111). PMID- 9945517 TI - Anomalous electrical behavior of n-type InP. PMID- 9945519 TI - Band-gap discontinuities for Ge/ZnSe(100) and Si/ZnSe(100): A photoemission study. PMID- 9945518 TI - Intersubband excitations in a periodic array of two-dimensional stripes. PMID- 9945520 TI - Brillouin scattering from amorphous materials at high pressures. PMID- 9945522 TI - Erratum: Dielectric parameters of alkali halides PMID- 9945521 TI - Line shift of two-photon transitions of Eu2+ in CaF2 as a function of temperature. PMID- 9945524 TI - Enhanced inelastic scattering and localization of excitons in In0.53Ga0.47As/InP alloy quantum wells. PMID- 9945523 TI - Erratum: Theory of exchange interactions and chemical trends in diluted magnetic semiconductors PMID- 9945525 TI - Thickness- and temperature-dependent spin anisotropy of ultrathin epitaxial Fe films on Ag(100). PMID- 9945527 TI - Low-temperature depinning of sliding charge-density waves. PMID- 9945526 TI - Localized states at metal-metal interfaces: An inverse photoemission study of Pd/Nb(110). PMID- 9945528 TI - Dopant incorporation, Fermi-level movement, and band offset at the Ge/GaAs(001) interface. PMID- 9945530 TI - Evidence of a mobility edge in the second subband of an Al0.33Ga0.67As-GaAs heterojunction. PMID- 9945529 TI - Hydrostatic and uniaxial pressure coefficients of CdTe. PMID- 9945531 TI - Excitonic transitions in lattice-matched Ga1-xInxAs/InP quantum wells. PMID- 9945532 TI - Exciton-polariton picture of the free-exciton lifetime in GaAs. PMID- 9945533 TI - Binding energy of shallow acceptors in InxGa1-xAs/GaAs strained quantum wells. PMID- 9945534 TI - Termination of the series of fractional quantum Hall states at small filling factors. PMID- 9945535 TI - Monolayer growth and structure of Ga on Si(111). PMID- 9945536 TI - Electron correlation in low-carrier-density metals: Photo- emission study of the hole-doped Mott insulator LixZn1-xV2O4. PMID- 9945538 TI - Multilayer relaxation of the Al(210) surface. PMID- 9945537 TI - Resistance fluctuations in a four-probe geometry with infinite leads. PMID- 9945539 TI - Depolarization effects due to the interaction between adsorbed dipoles on stepped surfaces. PMID- 9945540 TI - Third-order elastic constants from molecular dynamics: Theory and an example calculation. PMID- 9945541 TI - Elastic constants of KMnF3 as functions of temperature and pressure. PMID- 9945542 TI - Elastic constants of bcc shape-memory binary alloys: Effect of the configurational ordering. PMID- 9945543 TI - Electronic and structural properties of elemental copper: A pseudopotential-local orbital calculation. PMID- 9945544 TI - Extinction of electromagnetic waves by a small gyrotropic sphere. PMID- 9945545 TI - X-ray study of vanadium-doped blue bronze. PMID- 9945546 TI - Bulk contribution in surface second-harmonic generation. PMID- 9945548 TI - Electronic-structure study of RuS2. PMID- 9945547 TI - Optical nonlinear response of small metal particles: A self-consistent calculation. PMID- 9945549 TI - Photostimulated desorption of negative H- ions from a cesiated W(100) surface. PMID- 9945550 TI - Theory of the alkali-metal chemisorption on metal surfaces. PMID- 9945551 TI - Magnetic anisotropy in density-functional theory. PMID- 9945553 TI - Propagator study of the selvedge field in linear and nonlinear nonlocal jellium optics. PMID- 9945552 TI - Self-interstitial solute complexes in e--irradiated dilute Al-Ag and Al-Si alloys. PMID- 9945554 TI - Electric-field-dependent localization in a superlattice. PMID- 9945555 TI - Acoustic-wave propagation in quasiperiodic, incommensurate, and random systems. PMID- 9945556 TI - Optical activity in the incommensurate structure Rb2ZnBr PMID- 9945558 TI - Phonon dispersion in a metallic glass. PMID- 9945557 TI - Low-temperature resistivity and magnetoresistance of the quasicrystalline icosahedral Al80Mn20 and decagonal Al78Mn22 alloys. PMID- 9945559 TI - Crossover from dispersive to nondispersive transport in a trap-controlled hopping model. PMID- 9945560 TI - Friction coefficient of adatoms on metal surfaces at low temperatures. PMID- 9945561 TI - Microcrystalline and interface structure of metallic multilayers from x-ray spectra. PMID- 9945562 TI - Magnetoresistance of metallic point contacts. PMID- 9945563 TI - Dopant effect on intrinsic diffusivity in nickel silicide. PMID- 9945564 TI - Anomalous high-frequency modes of "missing-row" reconstructed (110) surfaces. PMID- 9945565 TI - Interchain order, soliton confinement, and electron-hole photogeneration in trans polyacetylene. PMID- 9945566 TI - Third-order optical nonlinearities in semiconductor microstructures. PMID- 9945568 TI - Size effects in multisubband quantum wire structures. PMID- 9945567 TI - Molecular-dynamics simulation of cluster and atom deposition on silicon (111). PMID- 9945569 TI - Configurational statistics in a-SixNyHz alloys: A quantitative bonding analysis. PMID- 9945570 TI - Band offsets in heterostructures with thin interlayers. PMID- 9945571 TI - Positron-annihilation spectroscopy of native vacancies in as-grown GaAs. PMID- 9945572 TI - Calculations of inelastic light scattering from surface plasmons with null critical wave vector in a metal-insulator semi-infinite superlattice. PMID- 9945573 TI - Oscillating magnetization of quantum-well electrons in a parallel magnetic field. PMID- 9945574 TI - Effect of gain nonlinearity in semiconductor lasers. PMID- 9945575 TI - Nature of the dominant deep trap in amorphous silicon nitride. PMID- 9945576 TI - Balance-equation analysis of hot-carrier transport in a type-II semiconductor superlattice. PMID- 9945577 TI - Surface-bonding geometry of (2 x 1)S/Ge(001) by the normal-emission angle resolved photoemission extended-fine-structure technique. PMID- 9945578 TI - Interaction-driven dimensional crossover for a superlattice in a strong magnetic field: Hartree-Fock theory. PMID- 9945579 TI - Structural and electronic properties of spinel semiconductors: An ab initio pseudopotential study of MgIn2S PMID- 9945580 TI - Bonding at the CaF2/Si(111) interface from tight-binding cluster and band theory. PMID- 9945581 TI - Semiconductor noise. PMID- 9945582 TI - Noise of junction devices. PMID- 9945584 TI - Ambipolar transport in amorphous semiconductors in the lifetime and relaxation time regimes investigated by the steady-state photocarrier grating technique. PMID- 9945583 TI - Effects of hydrostatic pressure and phosphorus alloying on the Ag acceptor level in GaAs. PMID- 9945585 TI - Quantum-confined interband absorption in GaAs sawtooth-doping superlattices. PMID- 9945586 TI - Excitonic transitions in ZnSe epilayers grown on GaAs. PMID- 9945587 TI - Plasmons in finite type-II semiconductor multilayers. PMID- 9945588 TI - One- and three-dimensional photoconductive response of highly oriented polyacetylene. PMID- 9945590 TI - Tunable absorption in a ssV-shaped multiple-quantum-well structure. PMID- 9945589 TI - Optical properties and Raman spectra of the quasi-one-dimensional gold complexes AuX2dibenzylsulfide (X2=Cl2,ClBr,Br2). PMID- 9945592 TI - Theoretical analysis of electronic structures of short-period superlattices (GaAs)m/(AlAs)n and corresponding alloys Aln/(m+n)Gam/(m+n)As. PMID- 9945591 TI - Six-probe resistance measurements. PMID- 9945593 TI - Theory of hole resonant tunneling in quantum-well structures. PMID- 9945594 TI - Thermally induced metastable defects in hydrogenated amorphous silicon and silicon-carbon alloy films. PMID- 9945595 TI - Intersubband optical absorption in coupled quantum wells under an applied electric field. PMID- 9945596 TI - Electronic structure of the 2.087-eV bound exciton related to the Lii-LiGa-OP complex defect in GaP. PMID- 9945597 TI - Cyclotron resonance of an interface polaron in polar-polar crystals. PMID- 9945598 TI - Electronic band structure and nonparabolicity in strained-layer Si-Si1-xGex superlattices. PMID- 9945599 TI - Wannier-Stark levels in the valence band of semiconductor multiple quantum wells. PMID- 9945601 TI - Infrared activity of alpha -AlPO4. PMID- 9945600 TI - Magnetic-ion-pair interaction in (Cd,Mn)Te and (Cd,Mn)Se using spin-flip Raman scattering and magnetization. PMID- 9945603 TI - Attenuated total-reflectance spectra of strongly absorbing anisotropic single crystals: Trigonal alpha -quartz. PMID- 9945602 TI - Mechanism of interaction of strain fields and two-level systems in amorphous dielectrics at low temperature. PMID- 9945604 TI - Effects of isolated atomic collision cascades on SiO2/Si interfaces studied by scanning tunneling microscopy. PMID- 9945605 TI - Azimuthally resolved optical second-harmonic generation from hydrogen on nickel (111). PMID- 9945606 TI - Study of magnetic susceptibility of CeNiAl and its hydrides. PMID- 9945607 TI - Polarons, bipolarons, and the bipolaron lattice in a linearly conjugated nondegenerate diatomic polymer. PMID- 9945608 TI - s-d transition and the universal equation of state. PMID- 9945609 TI - Photoelectron spectroscopy of single-size Au clusters collected on a substrate. PMID- 9945610 TI - New isoelectronic trap: Antimony in indium phosphide. PMID- 9945612 TI - Cyclotron mass of electrons in GaAs-Ga1-xAlxAs quantum wells. PMID- 9945611 TI - Optical studies in InxGa PMID- 9945614 TI - Raman scattering from TO phonons in (GaAs)n/(AlAs)n superlattices. PMID- 9945613 TI - Effect of shallow secondary impurities on the hopping activation energy in semiconductors. PMID- 9945615 TI - Nonlinear dc conductivity in disordered metals near the metal-insulator transition. PMID- 9945616 TI - Kinetic-energy and mass analysis of carbon cluster ions in pulsed-laser stimulated field evaporation. PMID- 9945617 TI - Uniaxial strain events in molecular-dynamics simulations of small rafts of xenon physisorbed on Pt(111). PMID- 9945618 TI - Functional-integral approach to an exactly soluble one-dimensional electron phonon system. PMID- 9945619 TI - 2 pi level of chemisorbed CO on Ni(111): Nearest-neighbor interactions versus bonding to the substrate. PMID- 9945620 TI - Electronic structure of fcc and bcc close-packed silver surfaces. PMID- 9945621 TI - Short-range order in a partially crystallized Fe0.86B0.14 amorphous alloy: A comparison between spin-echo NMR and Mossbauer-effect studies. PMID- 9945623 TI - Selection rules and extended x-ray bremsstrahlung isochromat spectra of Cu and Pd. PMID- 9945622 TI - Structure of micro-MnAl4, a crystalline phase with composition close to that of quasicrystalline phases. PMID- 9945624 TI - Vanishing Hall voltage in a quasi-one-dimensional GaAs-AlxGa1-xAs heterojunction. PMID- 9945625 TI - Photoluminescence study of confined donors in GaAs/AlxGa PMID- 9945626 TI - Surface plasmons on doped-semiconductor films: Influence of the depletion region. PMID- 9945628 TI - Dynamical mass effect on confined exciton states. PMID- 9945627 TI - Impact ionization of free excitons and electron-hole droplets in silicon in weak electric and magnetic fields. PMID- 9945629 TI - Optical and electron paramagnetic resonance studies of Fe impurities in yttrium aluminum garnet crystals. PMID- 9945631 TI - Rigorous theory for chemical shifts in crystal: Application to graphite. PMID- 9945630 TI - Radiation-enhanced diffusion in amorphous Pd-Cu-Si. PMID- 9945632 TI - X-ray fluorescence of layered synthetic materials with interfacial roughness. PMID- 9945633 TI - Theoretical Mossbauer isomer shift of antimony chalcogenides. PMID- 9945634 TI - Resplitting of exchange-merged NMR absorption lines at high spin polarizations. PMID- 9945636 TI - 39K and 77Se NMR study of the paraelectric-to-incommensurate phase transition of K2SeO4. PMID- 9945637 TI - Velocity and work-function dependence of secondary-ion emission. PMID- 9945635 TI - Nuclear-quadrupole induction of atomic polarization. PMID- 9945639 TI - Charge-state dependence of fast heavy-ion-induced desorption yields described in a thermal model. PMID- 9945638 TI - Desorption yield for valine as induced by fast heavy ions. PMID- 9945641 TI - Determination of azimuth angle, incidence angle, and contact-potential difference for low-energy electron-diffraction fine-structure measurements. PMID- 9945640 TI - Polarization effects in magnetic resonance: Application to a chainlike system. PMID- 9945642 TI - EPR of Gd3+-doped single crystals of LiY1-xYbx PMID- 9945644 TI - Electronic correlations and satellites in superconducting oxides. PMID- 9945643 TI - Monte Carlo calculation of the Gd3+ EPR linewidth due to the dipole-dipole interaction in YbCl3 PMID- 9945645 TI - Dependence of superconducting thermodynamics ratios on the shape of the electron phonon spectral density. PMID- 9945646 TI - Quantum fluctuations and the universal critical current in a granular superconducting film. PMID- 9945647 TI - Subharmonic energy-gap structure in superconducting weak links. PMID- 9945648 TI - Phase locking of Josephson-junction series arrays. PMID- 9945650 TI - Magnetism and superconductivity in (Er0.16Ho0.84)Rh4B4. PMID- 9945649 TI - Antiferromagnetic ordering of Cu ions in NdBa2Cu PMID- 9945652 TI - Crossover scaling in a dilute Bose superfluid near zero temperature. PMID- 9945651 TI - Monte Carlo simulations for a nonlocal sine-Gordon theory, vortex fluctuations, and connections to superconducting films. PMID- 9945653 TI - Complete wetting of helium on graphite. PMID- 9945654 TI - Perturbation theory of superconducting micronetworks near the phase-transition boundary. PMID- 9945655 TI - Evaporation and quantum tunneling of electrons from a helium surface. PMID- 9945656 TI - Fermi-liquid theory for the periodic Anderson model: Response functions. PMID- 9945657 TI - Field-dependent transport properties in paramagnon systems. PMID- 9945659 TI - Proximity effect of a ferromagnetic insulator in contact with a superconductor. PMID- 9945658 TI - Ground-state density profile of the weakly interacting Bose and Fermi gases confined in an arbitrary potential well. PMID- 9945660 TI - Coefficient of first viscosity via three-phonon processes in bulk liquid helium. PMID- 9945661 TI - Thermal conductivity and viscosity via phonon-phonon, phonon-roton, and roton roton scattering in thin 4He films. PMID- 9945663 TI - Exchange-driven ferric low-spin high-spin transition in iron-doped YBa2Cu3O7. PMID- 9945662 TI - Effects of Sr doping on the optical properties of polycrystalline La2-xSrxCuO4-y. PMID- 9945664 TI - Substitution for copper in YBa2Cu3Oy: The first 3% PMID- 9945665 TI - Structure and bonding of Bi-Sr-Ca-Cu-O crystal by x-ray photoelectron spectroscopy. PMID- 9945666 TI - Carrier location in high-Tc superconductors and the degree of Cu-O covalency. PMID- 9945667 TI - Magnetic polarons in the two-dimensional Hubbard model. PMID- 9945669 TI - Mixed valency, hole concentration, and Tc in YBa2Cu PMID- 9945668 TI - Preparation, structure, and properties of the superconducting compound series Bi2Sr2Can-1CunOy with n=1, 2, and 3. PMID- 9945670 TI - Response functions of a superlattice with a basis: A model for oxide superconductors. PMID- 9945671 TI - Superconductivity and lattice distortions in high-Tc superconductors. PMID- 9945672 TI - Crystal-field and exchange interactions of dilute Gd3+ ions in Eu2CuO4. PMID- 9945673 TI - Superconductivity in the Hubbard model. PMID- 9945674 TI - Mossbauer studies of the high-Tc superconductor YBa2(Cu1-xFex57)3O7- delta (x=0.033). PMID- 9945675 TI - Epitaxy and disorientations in the ferroelastic superconductor YBa2Cu3O7-x. PMID- 9945676 TI - Quasiparticle creation and condensation in a resonating-valence-bond superconductor. PMID- 9945678 TI - Simulation of vacancies in a two-dimensional Ising antiferromagnet. PMID- 9945677 TI - Phenomenological theory of ferromagnets without anisotropy. PMID- 9945679 TI - Surface melting of multilayer oxygen films on graphite studied by neutron diffraction. PMID- 9945680 TI - Renormalization-group technique applied to quenched systems. PMID- 9945681 TI - Static critical behavior of the two-dimensional Ising spin glass Rb2Cu1-xCoxF4. PMID- 9945682 TI - Amorphous magnetism in MnxSn PMID- 9945683 TI - First-order unbinding transition of an interface in two dimensions. PMID- 9945684 TI - Linear dielectric-breakdown electrostatics. PMID- 9945685 TI - Influence of charge-density-wave structure on paramagnetic spin waves in alkali metals. PMID- 9945686 TI - Domain growth in the field-theoretic version of the Potts model. PMID- 9945687 TI - Fractal approach in petrology: Small-angle neutron scattering experiments with volcanic rocks. PMID- 9945688 TI - Neutron diffraction study of alpha -MnC2O PMID- 9945689 TI - Pressure-temperature phase diagram of gamma -phase propylammonium tetrachloromanganate. PMID- 9945690 TI - Anomalous and subanomalous diffusion in stochastic trapping transport. PMID- 9945691 TI - Wetting layers caused by surface ionization in a near-critical binary liquid mixture. PMID- 9945693 TI - Constant-stress molecular dynamics: The phase diagram of silver iodide. PMID- 9945692 TI - Effective strong-coupling Hamiltonians for bipolaron centers and magnetic impurities with on-site electron-phonon coupling. PMID- 9945694 TI - Analysis of a new set of renormalization equations for the Kosterlitz-Thouless transition. PMID- 9945695 TI - Monte Carlo and high-temperature-expansion calculations of a spin-glass effective Hamiltonian. PMID- 9945696 TI - Monte Carlo simulations of the electron glass. PMID- 9945697 TI - Variational theory for the orbital-degenerate periodic Anderson model. PMID- 9945698 TI - Incommensurate phases in barium sodium niobate: Transmission-electron-microscopy study. PMID- 9945700 TI - Two-ion-interaction and crystal-field effects on the resistivity and susceptibility of hybridizing cerium systems. PMID- 9945699 TI - Magnetic susceptibility and exchange in IV-VI compound diluted magnetic semiconductors. PMID- 9945701 TI - Mechanism for the occurrence of paramagnetic planes within magnetically ordered cerium systems. PMID- 9945702 TI - Ferromagnetic strip domains in an atomic monolayer. PMID- 9945703 TI - Energy-density correlation function of the Ising model in small magnetic fields for T= Tg. PMID- 9946096 TI - Magnetic structures of fcc systems with nearest-neighbor and next-nearest neighbor exchange interactions. PMID- 9946095 TI - Magnetoconductivity near the percolation threshold in granular Sn:Ar mixtures. PMID- 9946097 TI - Low-temperature magnetic structure of MnO: A high-resolution neutron-diffraction study. PMID- 9946098 TI - Growth law of order-parameter fluctuation in a random interface system. PMID- 9946099 TI - Observable effects of the quantum adiabatic phase for noncyclic evolution. PMID- 9946100 TI - Nonlinear magnetic lattice and the modified Korteweg-de Vries equation. PMID- 9946101 TI - Further results for infinite conservation laws in the one-dimensional Hubbard model. PMID- 9946103 TI - Comment on "Magnons and solitons in a spin-1 antiferromagnetic Heisenberg-Ising ring" PMID- 9946102 TI - Comment on "Critical behavior of the three-dimensional site-random Ising magnet: MnxZn PMID- 9946104 TI - Pippard-coherence-length tensor for anisotropic superconductors. PMID- 9946105 TI - Comparative study of secondary-electron emission from positron and electron bombardment of Ni, Si, and MgO. PMID- 9946106 TI - Conversion-electron Mossbauer spectroscopy studies in amorphous Tb-Fe films. PMID- 9946108 TI - Quasiparticles in the copper-oxygen planes of high-Tc superconductors: An exact solution for a ferromagnetic background. PMID- 9946107 TI - Gap anisotropy and phonon self-energy effects in single-crystal YBa2Cu3O7- delta. PMID- 9946109 TI - Specific-heat measurements on superconducting Bi-Ca-Sr-Cu and Tl-Ca-Ba-Cu oxides: Absence of a linear term in the specific heat of Bi-Ca-Sr-Cu oxides. PMID- 9946110 TI - Orientation of the O 2p holes in Bi2Sr2Ca1Cu2O8. PMID- 9946111 TI - Elastic response of polycrystalline and single-crystal YBa2Cu3O7. PMID- 9946112 TI - Crystal structure of a new high-Tc TlBa2Ca3Cu4O11 superconductor by high resolution electron microscopy. PMID- 9946113 TI - Raman scattering spectra of superconducting Bi2Sr2CaCu2O8 single crystals. PMID- 9946114 TI - Reversible magnetization of high-Tc materials in intermediate fields. PMID- 9946115 TI - Systematic Raman study of Tl2Can-1Ba2 CunO4+2n (n=1,2,3) high-temperature superconductors. PMID- 9946116 TI - Photoemission from single crystals of EuBa2Cu3O7-x cleaved below 20 K: Temperature-dependent oxygen loss. PMID- 9946117 TI - Microwave transmission through films of YBa2Cu3O7- delta. PMID- 9946118 TI - Anisotropic microwave absorption of Bi-Sr-Ca-Cu-O single crystals. PMID- 9946119 TI - Superconducting fluctuations in specific heat in a magnetic field: Dimensional crossover. PMID- 9946120 TI - Far-infrared optical properties of Bi2Sr2CaCu2O8. PMID- 9946122 TI - Frequency-dependent ultrasonic attenuation of YBa2Cu3O7. PMID- 9946121 TI - Raman study of the phonon anomaly in single-crystal YBa2Cu3O7- delta in the presence of a magnetic field. PMID- 9946123 TI - Out-of-plane transport mechanism in the high-Tc oxide Y-Ba-Cu-O. PMID- 9946124 TI - Construction of a well-defined free energy from the harmonic approximation for Josephson junctions. PMID- 9946125 TI - Metal-insulator transition in random superconducting networks. PMID- 9946126 TI - Charge-e bosons, neutral fermions, and h/2e flux-field theory models. PMID- 9946127 TI - Magnetic ordering in GdBa2Cu3O6.14. PMID- 9946128 TI - Wetting of the PMID- 9946129 TI - Ferromagnetism of ultrathin films. PMID- 9946130 TI - Critical exponents of percolating wire networks. PMID- 9946132 TI - Universality of the dipolar dynamic crossover of cubic ferromagnets above Tc. PMID- 9946131 TI - Stable Monte Carlo algorithm for fermion lattice systems at low temperatures. PMID- 9946134 TI - Nature of the glass transition. PMID- 9946133 TI - Landau theory of coherent interphase interfaces. PMID- 9946135 TI - Melting transition of the S1 phase of ethane adsorbed on graphite. PMID- 9946136 TI - Bond-charge Coulomb repulsion in Peierls-Hubbard models. PMID- 9946137 TI - Pairing interaction in the heavy-fermion lattice. PMID- 9946138 TI - Ordered Fe3Pt Invar: No evidence for the transition from the high-spin to the low spin state. PMID- 9946139 TI - Application of the method of effective potentials to a model for twinning in elastic materials. PMID- 9946140 TI - Temperature dependence of the high-energy magnetic excitations for Ni. PMID- 9946141 TI - Determination of diatomic crystal bond lengths using atomic s-orbital radii. PMID- 9946142 TI - Lattice dynamics of layered MPX PMID- 9946143 TI - Lattice dynamics of lithium intercalated FePS3 compounds. PMID- 9946144 TI - Evidence for a temperature-dependent tunneling parameter. PMID- 9946145 TI - Low-energy electron diffraction study of potassium adsorbed on Ni(111). PMID- 9946146 TI - First-principles study of L10 Ti-Al and V-Al alloys. PMID- 9946147 TI - Universal distributions and scaling in disordered systems. PMID- 9946149 TI - Theory of surface resonant phonons on the (110) surface of silver. PMID- 9946148 TI - Interaction between adsorbed chalcogen and Al atoms on Al(001). PMID- 9946150 TI - Size effects in the magnetoresistance of rolled potassium films. PMID- 9946151 TI - Electronic structure of a hydrogen impurity near a (001) Pd surface. PMID- 9946152 TI - Structural, electronic, and magnetic properties of clean and Ag-covered Fe monolayers on W(110). PMID- 9946154 TI - Ground and excited states of the NaCl:Cu+ impurity system. PMID- 9946153 TI - Interface-state properties for strained-layer Ni adsorbed on Ru(0001). PMID- 9946155 TI - Damping of a crystal oscillator by an adsorbed monolayer and its relation to interfacial viscosity. PMID- 9946157 TI - Global mass dependence of the isotope effect in diffusion. PMID- 9946156 TI - Observation of near-surface damage by phonon scattering. PMID- 9946158 TI - Compton profile of polycrystalline tungsten. PMID- 9946159 TI - Electrical field effects near the metal-insulator transition. PMID- 9946161 TI - Spectroscopic results on the above and below EF electronic structure of TAl2, T=Au and Pt. PMID- 9946160 TI - Jellium work function for all electron densities. PMID- 9946162 TI - Electronic transmission coefficient for the single-impurity problem in the scattering-matrix approach. PMID- 9946163 TI - Synchrotron photoemission study of CO chemisorption on Cr(110). PMID- 9946164 TI - Unoccupied states on Pd(110) and the surface potential barrier. PMID- 9946165 TI - Interaction between tunneling impurities in metals. PMID- 9946166 TI - Diffuse low-energy electron diffraction study of disordered O/Ni(100). PMID- 9946168 TI - Anomalous field dependence of the Hall coefficient in disordered metals. PMID- 9946167 TI - Electrical resistance of nickel in the range 300-725 K and 0-2 GPa. PMID- 9946169 TI - Quantum size effects in transport properties of metallic films. PMID- 9946171 TI - Nonlinear effects in desorption of valine with fast incident molecular ions. PMID- 9946170 TI - High-pressure behavior of quasi-one-dimensional 2H-CsCdBr3. PMID- 9946172 TI - Lattice dynamics of Cu(110): High-resolution He-scattering study. PMID- 9946173 TI - Planar defects and surfaces in crystals undergoing structural phase transitions. PMID- 9946174 TI - Optical properties of AlxGa1-xAs alloys. PMID- 9946175 TI - Band structure of a semimagnetic semiconducting alloy: A photoemission study of Cd1-xMnxTe. PMID- 9946176 TI - Anisotropic magnetotransport in weakly coupled GaAs-AlxGa1-xAs multiple quantum wells. PMID- 9946177 TI - Phonon-polariton modes in superlattices: The effect of spatial dispersion. PMID- 9946178 TI - Oscillator strengths of shallow impurity spectra in germanium and silicon. PMID- 9946179 TI - Stress dependence of dislocation glide activation energy in single-crystal silicon-germanium alloys up to 2.6 GPa. PMID- 9946180 TI - Structure and bonding in photodiffused amorphous Ag-GeSe2 thin films. PMID- 9946181 TI - Capacitance measurements of magnetic localization and magnetic freezeout in n- type GaAs. PMID- 9946182 TI - Microscopic calculation of electric field effects in GaAs/AlxGa1-xAs/GaAs tunnel structures. PMID- 9946184 TI - Magnetoplasmons in thin films in the perpendicular configuration. PMID- 9946183 TI - Streaking images that appear only in the plane of diffraction in undoped GaAs single crystals: Diffraction imaging (topography) by monochromatic synchrotron radiation. PMID- 9946185 TI - Model for minority-carrier band-gap states in semiconductors. PMID- 9946186 TI - Optical investigation of confinement and strain effects in CdTe/Cd1-xZnxTe single quantum wells. PMID- 9946187 TI - Metastable effects in the dc conductivity of undoped glow discharge and sputtered hydrogenated amorphous silicon. PMID- 9946189 TI - Effect of biaxial strain on exciton luminescence of heteroepitaxial ZnSe layers. PMID- 9946188 TI - Dependence of Hg1-xCdxTe-CdTe superlattice band structure on well and barrier thickness, strain, valence-band offset, and well composition. PMID- 9946190 TI - Long-wavelength phonons in TlSbS2: Raman-active modes. PMID- 9946191 TI - Reversible photoinduced change of ac conduction in amorphous As2S3 films. PMID- 9946192 TI - Optical-absorption profile of a single modulation-doped AlxGa1-xAs/GaAs heterojunction. PMID- 9946193 TI - Complete tight-binding description of the empirical-local-pseudopotential Hamiltonian in zinc-blende semiconductors. PMID- 9946194 TI - Effective-mass approximation in semiconductor heterostructures: One-dimensional analysis. PMID- 9946195 TI - Interaction of F and Cl with silicon surfaces. PMID- 9946196 TI - Picosecond response of photoexcited GaAs in a uniform electric field by Monte Carlo dynamics. PMID- 9946197 TI - Optical detection of microwave-induced impact ionization of bound excitons in silicon. PMID- 9946199 TI - Polaritons in an n-i-p-i semiconductor superlattice: Bulk and surface modes. PMID- 9946198 TI - Energetic study of polarons and bipolarons in polythiophene: Importance of Coulomb effects. PMID- 9946200 TI - Hydrostatic-pressure dependencies of deep impurity levels in zinc-blende semiconductors. PMID- 9946201 TI - Investigation of the electronic structures and associated properties including hyperfine interactions for halogen-adsorbed silicon surfaces: Fluorine through iodine. PMID- 9946202 TI - Hot-electron transport through thin dielectric films: Boltzmann theory and electron spectroscopy. PMID- 9946203 TI - Conduction-band structure of graphite single crystals studied by angle-resolved inverse photoemission and target-current spectroscopy. PMID- 9946204 TI - Generalized dynamic-disorder transport rule with application to the study of temporal correlation effects. PMID- 9946205 TI - Quasielastic light scattering in the one-dimensional superionic conductor hollandites. PMID- 9946207 TI - Magnetic-susceptibility studies of graphite intercalation compounds. PMID- 9946206 TI - Resonant scattering and thermal transport in orientational glasses. PMID- 9946208 TI - Electronic charge transfer in stage-2 fluorine-intercalated graphite compounds. PMID- 9946210 TI - Fluctuations of ultrasonic attenuation in mesoscopic systems: A test for isolated geometries. PMID- 9946209 TI - Phase transitions in LiKSO4 below room temperature. PMID- 9946211 TI - Calculation of the thermal expansion of metals using the embedded-atom method. PMID- 9946212 TI - Comparison of calculations of dynamical screening at jellium surfaces. PMID- 9946213 TI - Ferromagnetic spin waves in quasiperiodic superlattices. PMID- 9946215 TI - Elastic properties of Si during amorphization. PMID- 9946214 TI - Anisotropies of Compton profiles in nickel. PMID- 9946216 TI - Effects of interlevel coupling on optically detected magnetic resonance spectra for complex defects in semiconductors. PMID- 9946218 TI - Microscopic structure of boron-hydrogen complexes in crystalline silicon. PMID- 9946217 TI - Interaction between two hole gases in a modulation-doped quantum well. PMID- 9946219 TI - Kink mechanism for formation of the Si(111)-(2 x 1) reconstructed surface. PMID- 9946220 TI - Ground-state and electronic properties of covalent solids. PMID- 9946222 TI - Effects of topological distortion on the properties of silicon. PMID- 9946221 TI - Quantum-mechanical effects in nonlinear magnetotransport. PMID- 9946223 TI - Possibility of heterostructure band offsets as bulk properties: Transitivity rule and orientation effects. PMID- 9946225 TI - Erratum: Atomic structure and ordering in semiconductor alloys PMID- 9946224 TI - Pressure-tuning resonance between the vibron and the libron in CH2BrI molecular solid. PMID- 9946226 TI - Examination of the Cu/Si(111) 5 x 5 structure by scanning tunneling microscopy. PMID- 9946228 TI - Surface-enhanced Raman scattering of the pyridine-KCl-water-copper system: Temperature dependence. PMID- 9946227 TI - Sulfur-induced occupation of Delta -bar Fe minority surface states in c(2 x 2) S/Fe(001). PMID- 9946229 TI - Resonant inverse photoemission involving transition-metal 3p-3d subshell interactions. PMID- 9946230 TI - Reaction of thin Pd films with Al(111) and Al(110) surfaces. PMID- 9946231 TI - Time-resolved photoluminescence study of excitonic relaxation in one-dimensional systems. PMID- 9946232 TI - Doubly resonant Raman scattering induced by an electric field. PMID- 9946233 TI - Negative resistance fluctuations at resistance minima in narrow quantum Hall conductors. PMID- 9946234 TI - delta doping in strained (Si)/(Ge) superlattices. PMID- 9946235 TI - Far-infrared response of one-dimensional electronic systems in single- and two layered quantum wires. PMID- 9946236 TI - New classical potential for accurate simulation of atomic processes in Si. PMID- 9946238 TI - Two-subband transport: A conundrum in scattering. PMID- 9946237 TI - Reversible and remanent charge-density-wave polarization at low temperatures. PMID- 9946239 TI - Gain measurements and band-gap renormalization in GaAs/AlxGa1-xAs multiple quantum-well structures. PMID- 9946241 TI - Composition pinning in epitaxial alloys. PMID- 9946240 TI - Formation energies, abundances, and the electronic structure of native defects in cubic SiC. PMID- 9946242 TI - Incoherent tunneling of electrons from three to two dimensions: Observation of conductance oscillations in a metal-insulator-semiconductor structure. PMID- 9946243 TI - Commutativity of the GaAs/AlAs(100) band offset. PMID- 9946244 TI - Screening properties of surface states at Si(111)2 x 1. PMID- 9946246 TI - Electronic and structural properties of LiBeH3. PMID- 9946245 TI - Two types of oxygen-deficient centers in synthetic silica glass. PMID- 9946247 TI - Atomically resolved scanning tunneling microscopy images of dislocations. PMID- 9946248 TI - Modified Broyden's method for accelerating convergence in self-consistent calculations. PMID- 9946249 TI - Optical behavior of a nonlinear thin film with oblique S-polarized incident wave. PMID- 9946251 TI - Local-density description of antiferromagnetic Cr. PMID- 9946250 TI - Surface properties of a heavy-fermion system: An exact many-body solution to a periodic-cluster Hubbard model. PMID- 9946252 TI - X-ray study of the structure of K1-xRbxC8. PMID- 9946253 TI - Determination of the off-center parameters in NaBr:Cu+ by pressure effects of the absorption bands. PMID- 9946254 TI - Electronic structure of the pseudobinary U(Rh1-yPdy PMID- 9946255 TI - Optical properties of metallic silicon. PMID- 9946256 TI - Freely-migrating-defect production during irradiation at elevated temperatures. PMID- 9946257 TI - Structural and magnetic properties of ultrathin Ni/Fe bilayers grown epitaxially on Ag(001). PMID- 9946258 TI - Surface-phonon calculations for the Al(110) surface. PMID- 9946259 TI - Strictly localized eigenstates on a three-dimensional Penrose lattice. PMID- 9946261 TI - Computer simulations of a distorted reciprocal lattice of an Al-Li-Cu single quasicrystal. PMID- 9946260 TI - Structural phase transition at 205 K in stoichiometric vanadium nitride. PMID- 9946262 TI - Electronic and superconducting properties of Mo-Ta superlattices. PMID- 9946264 TI - Screening effects on the quadrupole splitting in amorphous Fe-Zr alloys. PMID- 9946263 TI - Infinite screening and cluster calculations of ionization potentials. PMID- 9946265 TI - Stability of multiply positively charged homonuclear clusters. PMID- 9946266 TI - Rapid convergence of lattice sums and structural integrals in ordered and disordered systems. PMID- 9946267 TI - Prism-coupled light emission from tunnel junctions containing interface roughness: Theory. PMID- 9946269 TI - Model dielectric constants of Si and Ge. PMID- 9946268 TI - Prism-coupled light emission from tunnel junctions containing interface roughness: Experiment. PMID- 9946270 TI - Band structure of quantum wells under crossed electric and magnetic fields. PMID- 9946272 TI - Quantum-confined Stark effects on a GaAs cluster embedded in AlxGa PMID- 9946271 TI - Generalized master equations and other theories of the phonon-assisted hopping conduction. PMID- 9946273 TI - Structural and electronic properties of bulk ZnSe. PMID- 9946275 TI - Switching and charge-density-wave transport in NbSe3. II. ac characteristics. PMID- 9946274 TI - Switching and charge-density-wave transport in NbSe3. I. dc characteristics. PMID- 9946277 TI - Phase slips and switching in charge-density-wave transport. PMID- 9946276 TI - Switching and charge-density-wave transport in NbSe3. III. Dynamical instabilities. PMID- 9946279 TI - Theoretical investigation of collective excitations in HgTe/CdTe superlattices. II. Intersubband excitation and effects of magnetic field and electron-phonon coupling. PMID- 9946280 TI - Aluminum in complex luminescence defects in irradiated silicon. PMID- 9946278 TI - Theoretical investigation of collective excitations in HgTe/CdTe superlattices. I. Intrasubband excitation. PMID- 9946282 TI - Quantum transport in neutron-irradiated modulation-doped heterojunctions. II. Thermal neutrons. PMID- 9946283 TI - Superlattice k PMID- 9946281 TI - Quantum transport in neutron-irradiated modulation-doped heterojunctions. I. Fast neutrons. PMID- 9946285 TI - Ellipsometric study of optical transitions in Ag1-xInx alloys. PMID- 9946284 TI - Extended x-ray-absorption and electron-energy-loss fine-structure studies of the local atomic structure of amorphous unhydrogenated and hydrogenated silicon carbide. PMID- 9946286 TI - General comparison of the surface processes involved in nitridation of Si(100)-2 x 1 by NH3 and in SiNx film deposition: a photoemission study. PMID- 9946287 TI - Spatial and energetic distribution of Si-SiO2 near-interface states. PMID- 9946288 TI - Carrier-concentation-dependent electron-LO-phonon coupling observed in GaAs (Ga,Al)As heterojunctions by resonant-polaron cyclotron resonance. PMID- 9946289 TI - Piezo- and photomodulated reflectivity spectra of ZnSe/GaAs and CdTe/InSb epilayers. PMID- 9946290 TI - Noise spectroscopy of silicon grain boundaries. PMID- 9946291 TI - Disordering of the (111) surface of germanium crystal near its bulk melting temperature. PMID- 9946292 TI - Analysis of molecular-dynamics simulations of the (111) surface of germanium crystal near its bulk melting temperature. PMID- 9946293 TI - Interband Faraday effect in Cd1-xMnxSe. PMID- 9946294 TI - Stability of the (InAs)1/(GaAs)1 monolayer superlattice. PMID- 9946295 TI - Critical study of multivalley effective-mass equation for donors in silicon. PMID- 9946296 TI - Temperature dependence of photoluminescence in hydrogenated amorphous silicon. PMID- 9946297 TI - Pressure-induced Gamma -X transition in (Ga,In)P. PMID- 9946298 TI - X-ray diffraction study of the Ge(111)5 x 5-Sn and Ge(111)7 x 7-Sn surfaces. PMID- 9946300 TI - Optically detected magnetic resonance study of antisite-to-acceptor and related recombination processes in as-grown InP:Zn. PMID- 9946299 TI - Optical investigations on indirect-band-gap AlxGa1-xAs/AlyGa1-yAs superlattices. PMID- 9946301 TI - Electronic properties of the (100) (Si)/(Ge) strained-layer superlattices. PMID- 9946303 TI - Ab initio calculation of the mixing enthalpy of the GaAs-AlAs random alloy. PMID- 9946302 TI - Bistability of magnetic polarons bound to acceptors in a wurtzite semimagnetic semiconductor. PMID- 9946305 TI - Excitons near interfaces of polar-nonpolar crystals with strong interactions between the excitons and optical phonons. PMID- 9946304 TI - Band structure of carbonated amorphous silicon studied by optical, photoelectron, and x-ray spectroscopy. PMID- 9946306 TI - Local valence-band densities of states of AlxGa1-xAs. PMID- 9946307 TI - Auger-electron emission induced by Ar+ impact on silicides. PMID- 9946308 TI - Sulfur pair in silicon: 33S electron-nuclear double resonance. PMID- 9946309 TI - Influence of contacts on the magnetotransport in a two-dimensional electron gas. PMID- 9946310 TI - Formalism of the Kronig-Penney model for superlattices of variable basis. PMID- 9946311 TI - Exciton spectra in GaAs/Ga1-xAlxAs quantum wells in an externally applied electric field. PMID- 9946313 TI - Investigation of location, electronic structures, and associated properties of chalcogen atoms adsorbed on silicon surfaces: Sulfur and selenium. PMID- 9946312 TI - Energy relaxation of lower-dimensional hot carriers studied with picosecond photoluminescence. PMID- 9946314 TI - Anharmonic mixing between two phonons in red mercury iodide. PMID- 9946316 TI - Comparison between optically excited and electron-excited transitions above oxygen and nitrogen K edges in Cu2O, O/Al, O/Ni, SiO2, and Si3N PMID- 9946317 TI - Density-functional theory in insulators: Analytical model for Sigma xc, vxc, and the gap correction. PMID- 9946315 TI - Unoccupied electronic states of single-crystal graphite by angle-resolved ultraviolet inverse photoemission. PMID- 9946319 TI - Dielectric continuum model and Frohlich interaction in superlattices. PMID- 9946318 TI - Symmetric transmission electron momentum (e,2e) spectroscopy of an aluminum aluminum oxide thin foil. PMID- 9946320 TI - Polarons near the C PMID- 9946321 TI - Specific heat of poly(dG)-poly(dC) below 5 K. PMID- 9946322 TI - Early stages of the alkali-metal-promoted oxidation of silicon. PMID- 9946324 TI - Electronic stationary states in the presence of uniform electric and magnetic fields and a periodic potential. PMID- 9946323 TI - Effect of electrostatic screening on energy positions of electron spectra near SiO2/Si interfaces. PMID- 9946326 TI - Pressure studies of ZrO2-Al2O3 films grown by magnetron sputtering. PMID- 9946325 TI - Atomiclike behavior of the Mo 4d photoionization cross section in Mo islands grown on Al. PMID- 9946327 TI - Interface dipoles, surface work functions, and Schottky-barrier formation at Au/ZnSe(100) interfaces. PMID- 9946329 TI - Parallel channel to the Boltzmann band conduction: Scattering by charged screened impurities in semiconductors. PMID- 9946328 TI - Band structure of silicon from the semiempirical modified neglect of diatomic differential overlap method. PMID- 9946330 TI - Electron mobility in In0.53Ga0.47As quantum wells. PMID- 9946332 TI - Anomalous electrical resistivity and photovoltaic phenomenon in the fast-mixed conductor lithium silicide Li12Si PMID- 9946331 TI - Steady-state and transient photoconductivity in amorphous thin films of GexSe100 x. PMID- 9946333 TI - Coupling of electron gases in wide quantum wells. PMID- 9946335 TI - Epitaxial growth of metastable semiconductor alloys: A novel simulation. PMID- 9946334 TI - Optical nonlinearities in multiple quantum wells: New insight on band-gap renormalization. PMID- 9946337 TI - High-temperature light-induced effects in hydrogenated amorphous silicon. PMID- 9946338 TI - Surface electronic bands of GaAs(110) determined by angle-resolved inverse photoemission. PMID- 9946336 TI - Self-consistent band-edge deformation potentials in a tight-binding framework. PMID- 9946339 TI - Spectral behavior of the three-photon absorption coefficient in ionic crystals. PMID- 9946340 TI - Anomalous temperature dependence in the Raman spectra of l-alanine: Evidence for dynamic localization. PMID- 9946341 TI - Xe bubbles in Si observed by extended x-ray-absorption fine-structure spectroscopy. PMID- 9946343 TI - Sequential screening layers in a photoexcited In1-xGaxAs/InP superlattice. PMID- 9946342 TI - Multiphonon capture in the case of undistorted defects. PMID- 9946344 TI - Biexciton formation in GaAs/AlxGa1-xAs multiple quantum wells: An optical investigation. PMID- 9946346 TI - Anisotropy effects on excitonic properties in realistic quantum wells. PMID- 9946345 TI - Calculation of the diamagnetic shift in resonant-tunneling double-barrier GaAs/AlxGa1-xAs heterostructures. PMID- 9946348 TI - Energy levels and symmetries of palladium centers in silicon. PMID- 9946347 TI - Symmetry properties and band structure of surface states on the single-domain, hydrogen-chemisorbed Si(100)2 x 1:H surface. PMID- 9946349 TI - Intercalant depth profile in acceptor-type metal chloride graphite intercalation compounds. PMID- 9946351 TI - Line shape of an atom-crystal bond. PMID- 9946350 TI - Bonding of alpha -SiC basal planes to close-packed Ti, Cu, and Pt surfaces: Molecular-orbital theory. PMID- 9946352 TI - Retardation and many-body effects in multilayer-film adsorption. PMID- 9946353 TI - Semiclassical description of a two-dimensional electron in a strong magnetic field and an external potential. PMID- 9946355 TI - Relativistic calculations of 2p and 3d excitation energies in the actinide metals. PMID- 9946354 TI - Glancing-angle extended x-ray-absorption fine structure and reflectivity studies of interfacial regions. PMID- 9946356 TI - Theoretical calculations of core-core-valence Auger spectra: Applications to the L3M2,3V transitions of Ti in nonstoichiometric Ti-C, Ti-N, and Ti-O. PMID- 9946357 TI - Resonant-photoemission study of the mechanism for room-temperature-alloyed interface formation of Au and Ag on Si(111)-(2 x 1). PMID- 9946359 TI - Quantum-mechanical cluster-lattice interaction in crystal simulation: Hartree Fock method. PMID- 9946358 TI - Charge-state distribution of MeV He ions specularly reflected from a SnTe(001) surface. PMID- 9946360 TI - Quantum-mechanical cluster-lattice interaction in crystal simulation: Many-body effects. PMID- 9946361 TI - Thermal point-contact spectroscopy in UPt3. PMID- 9946362 TI - Temperature dependence of homogeneous spectral widths of the 2E-4A2 transition of Cr3+ in silver beta -alumina. PMID- 9946363 TI - Corrections to the effective-medium theory of embedding energies: Interstitial hydrogen in metals. PMID- 9946364 TI - Nucleation and growth of helium bubbles in aluminum between 20 and 900 K. PMID- 9946365 TI - Strong-coupling theory for the driving force in thermomigration. PMID- 9946367 TI - Hydrogen-induced phase separation in amorphous Cu0.5Ti0.5 alloys. II. Thermal evolution. PMID- 9946366 TI - Hydrogen-induced phase separation in amorphous Cu0.5Ti PMID- 9946368 TI - Jellium-model calculation for dimer decays of potassium clusters. PMID- 9946370 TI - Mechanical twinning in crystals. PMID- 9946369 TI - Angle-resolved photoemission from Cr(110): Observation of a bulk magnetic phase transition. PMID- 9946371 TI - Vacuum-ultraviolet spectra and band structure of BaPb1-xBix PMID- 9946372 TI - Theory of charge-density-wave dynamics. PMID- 9946373 TI - Invariant-embedding R-matrix scheme for reflection high-energy electron diffraction. PMID- 9946374 TI - Spin dynamics of Cd1-xMnxTe studied by muon spin relaxation and rotation. PMID- 9946376 TI - Optical properties of excitons in semi-infinite semiconductors. PMID- 9946375 TI - Investigation of the (Cu-Li)-related 2.172-eV bound exciton in GaP with optically detected magnetic resonance. PMID- 9946377 TI - Alloy broadening of the deep electronic levels associated with the As vacancy in AlxGa PMID- 9946378 TI - Reflectance spectroscopy on GaAs-Ga0.5Al0.5As single quantum wells under in-plane uniaxial stress at liquid-helium temperature. PMID- 9946379 TI - Transient resonant light scattering in a strongly coupled localized-electron phonon system. PMID- 9946380 TI - Rapid radiative decay and enhanced optical nonlinearity of excitons in a quantum well. PMID- 9946381 TI - Determination of the inversion-layer thickness from capacitance measurements of metal-oxide-semiconductor field-effect transistors with ultrathin oxide layers. PMID- 9946382 TI - Exciton-exciton interaction and optical nonlinearity in biased semiconductor quantum wells. PMID- 9946384 TI - Sensitivity of the absorption edge to applied electric fields in GaAs-Ga1-xAlxAs superlattices. PMID- 9946383 TI - Excitonic absorption in modulation-doped GaAs/AlxGa PMID- 9946386 TI - Remarkable effects of uniaxial stress on the far-infrared laser emission in p type Ge. PMID- 9946385 TI - Quantitative analysis of the effect of disorder-induced mode coupling on infrared absorption in silica. PMID- 9946387 TI - Effect of first-order phonon-assisted scattering on near-infrared free-carrier optical absorption in silicon. PMID- 9946388 TI - Valence-band structure and final states in photoemission from (112-bar0) surfaces of CdS and CdSe. PMID- 9946389 TI - n dependence of the valence-band offset in (GaAs)n(AlAs)n: Role of charge redistribution, interface dipoles, and cation 3d states. PMID- 9946390 TI - Magnetic polarons and electronic structure in semimagnetic superlattices: Application to CdTe/Cd1-xMnx PMID- 9946391 TI - Elastic constants of Zn1-xMnxSe: Tetrahedral bond weakening due to Mn 3d(t2)-Se 4p hybridization. PMID- 9946392 TI - Thin superlattices and band-gap discontinuities: The (110) diamond-boron nitride interface. PMID- 9946393 TI - Observation of decoupled heavy and light holes in GaAs-Ga1-xAlxAs quantum wells by magnetoreflectivity. PMID- 9946394 TI - Energetics of acceptor-bound magnetic polarons in diluted magnetic semiconductors. PMID- 9946395 TI - Density of states between Landau levels in a two-dimensional electron gas. PMID- 9946396 TI - Long-range atomic order in GaxIn1-xAsyP1-y epitaxial layers PMID- 9946397 TI - X-ray photoemission from small mercury clusters on II-VI semiconductor surfaces. PMID- 9946398 TI - Interaction of magnetoplasmons with optical phonons in polar semiconductors. PMID- 9946399 TI - Transient-photomodulation-spectroscopy studies of carrier thermalization and recombination in a-Si:H. PMID- 9946400 TI - Calculated electronic properties of tetragonal crystalline Si-Ge alloys: Comparison to amorphous phases. PMID- 9946401 TI - Monte Carlo studies of liquid semiconductor surfaces: Si and Ge. PMID- 9946402 TI - Full-potential linear-muffin-tin-orbital calculation of phonon frequencies in semiconductors. PMID- 9946403 TI - Electronic structure of the substitutional nitrogen NN1 pair in GaP from photoluminescence excitation and Zeeman spectroscopy. PMID- 9946404 TI - Nonequilibrium transport of an electron-phonon-hole system in a semiconductor quantum well. PMID- 9946405 TI - Optical characterization and band offsets in ZnSe-ZnSxSe PMID- 9946406 TI - Acoustic-phonon propagation in superlattices. PMID- 9946407 TI - Scattering-model calculation of the impurity-induced dephasing relaxation rates of the Raman-active J=2 rotons in solid parahydrogen. PMID- 9946408 TI - Raman study of the pressure-induced neutral-to-ionic transition in tetrathiafulvalene chloranil. PMID- 9946410 TI - Two-photon excitations of Ag- centers in RbBr. PMID- 9946409 TI - Fractal surface and cluster structure of controlled-pore glasses and Vycor porous glass as revealed by small-angle x-ray and neutron scattering. PMID- 9946412 TI - Energy surfaces and electronic properties of hydrogen fluoride. PMID- 9946411 TI - Temperature dependence of laser-induced bulk damage in SiO2 and borosilicate glass. PMID- 9946413 TI - Wannier excitons in semiconductor quantum wells with small valence-band offsets: A generalized variational approach. PMID- 9946414 TI - Ce 4f orbital coupling to transition-metal band structure: An ion-implantation study. PMID- 9946415 TI - Surface electronic structure of CoSi2(111). PMID- 9946416 TI - Threshold dependence in the electronic sputtering of condensed sulfur. PMID- 9946418 TI - Magic numbers for vacancy aggregation in crystalline Si. PMID- 9946417 TI - Observation of the surface vibrational resonances on Pd(110). PMID- 9946419 TI - Observation of the 2s state excitons in (111)-oriented GaAs/AlxGa PMID- 9946421 TI - Passivation of recombination centers on the WSe2 surface. PMID- 9946420 TI - High-field balance equations for electronic transport in weakly nonuniform systems. PMID- 9946422 TI - Elastic constants and phonon frequencies of Si calculated by a fast full potential linear-muffin-tin-orbital method. PMID- 9946423 TI - Pseudofunction theory of the electronic structure of InN. PMID- 9946424 TI - High-pressure neutron-scattering studies of graphite and stage-two graphite SbCl5. PMID- 9946425 TI - Correlation of the individual vacancy-formation parameters in NaCl. PMID- 9946426 TI - Dynamic light scattering at the nonequilibrium crystal-melt interface in biphenyl and naphthalene. PMID- 9946427 TI - Possible observation of transmission resonances in GaAs-AlxGa PMID- 9946428 TI - Fractional quantization in ultranarrow electron channels. PMID- 9946430 TI - Photoemission extended x-ray-absorption fine structure from clean and Al-covered InP(110) surfaces. PMID- 9946431 TI - First-overtone response in modulated photoluminescence emission in silicon at room temperature. PMID- 9946429 TI - Spectroscopic ellipsometry of sputtered amorphous Ni0.95Tb PMID- 9946433 TI - Pinning of charge-density waves to charged defects and an incomplete incommensurate-to-commensurate transition in the blue bronzes A0.3MoO3, A=Rb,K. PMID- 9946432 TI - Nonlinear optical properties of linear chains and electron-correlation effects. PMID- 9946434 TI - Hydrogen immobilization in silicon p-n junctions. PMID- 9946435 TI - Structure determination of the Ge(111)-c(2 x 8) surface by medium-energy ion scattering. PMID- 9946436 TI - Motional effects between on-center and off-center substitutional nitrogen in silicon. PMID- 9946438 TI - Localized and extended states in GaAs/AlxGa1-xAs superlattices probed by resonant optical excitation. PMID- 9946439 TI - dc conductivity and the Meyer-Neldel rule in a-Si:H. PMID- 9946437 TI - Negative magnetoresistance in uniaxially stressed Si(100) inversion layers. PMID- 9946441 TI - Magnetism in bcc 3d transition metals: Onset and approach to the Hund's-rule limit. PMID- 9946440 TI - Higher-harmonic bond-orientational correlations in a model planar hexatic glass. PMID- 9946442 TI - Strictly localized states on a two-dimensional Penrose lattice. PMID- 9946444 TI - Wavelength dependence of the 1s excitation spectrum of aluminum. PMID- 9946443 TI - Imaging of 5f densities of states in resonant photoemission measurements. PMID- 9946445 TI - Patterson Fourier analysis of the icosahedral (Al,Si)-Mn alloy. PMID- 9946446 TI - Six-dimensional Fourier analysis of the icosahedral Al73Mn PMID- 9946448 TI - Growth-induced phason strains in icosahedral quasicrystals of Al-Li-Cu. PMID- 9946447 TI - Time-dependent screening in the electron gas. PMID- 9946449 TI - Experimental determination of local-bonding configuration at the early stages of growth of the heterogeneous Pt/InP(110) interface by synchrotron-radiation spectroscopy. PMID- 9946450 TI - Narrow electronic bands in high electric fields: Static properties. PMID- 9946451 TI - Determination of the crystal structure of icosahedral Al-Cu-Li. PMID- 9946453 TI - Theory of the bcc-to-9R structural phase transformation of Li. PMID- 9946452 TI - Multiple-scattering calculations in two dimensions. PMID- 9946454 TI - Dependence of the positron reemission probability on the positron work function of a metal surface. PMID- 9946455 TI - Three classes of one-dimensional, two-tile Penrose tilings and the Fibonacci Kronig-Penney model as a generic case. PMID- 9946456 TI - Quantum theory of transient transport in a high electric field. PMID- 9946458 TI - Effect of defect structures on chemically active surfaces: A continuum approach. PMID- 9946457 TI - Multilayer relaxation at surfaces of body-centered-cubic transition metals. PMID- 9946459 TI - Exact solution of a periodic-cluster Hubbard model with an electron-lattice interaction. PMID- 9946460 TI - Solid-state binding, recombination, and Auger energy shifts of rare-earth metals. PMID- 9946462 TI - Angle-resolved photoemission studies of a surface state on a stepped Cu(332) surface. PMID- 9946461 TI - Observation of phonon anomalies in the intermediate-valence compound CePd3. PMID- 9946464 TI - Hole-subband mixing in quantum wells: A magnetooptic study. PMID- 9946463 TI - Chemisorption on binary alloys with long-range order. PMID- 9946466 TI - Relativistic band structure and spin-orbit splitting of zinc-blende-type semiconductors. PMID- 9946465 TI - Optical absorption from polarons and bipolarons in a tetrahedrally bonded homopolymer. PMID- 9946467 TI - Asymptotic localization of plasmons in a periodic array of stripes. PMID- 9946469 TI - Local-orbital basis for defect electronic structure calculations of an Al(100) film. PMID- 9946468 TI - Strained Si/Ge superlattices: Structural stability, growth, and electronic properties. PMID- 9946470 TI - Electron correlation and disorder in Hg1-xCdxTe in a magnetic field. PMID- 9946471 TI - Optical properties of crystalline semiconductors and dielectrics. PMID- 9946472 TI - Structure of a-GeSe2 from x-ray scattering measurements. PMID- 9946473 TI - Energy-band structure of CoSi2 epitaxially grown on Si(111). PMID- 9946474 TI - 119Sn Mossbauer study of shallow and deep states of Sn in Ga1-xAlxAs. PMID- 9946475 TI - Atomic distributions across metal-III-V-compound-semiconductor interfaces. PMID- 9946477 TI - Field theory for the one-dimensional optical polaron. II. Phonon-polaron scattering. PMID- 9946476 TI - Field theory for the one-dimensional optical polaron. I. Incorporation of the Goldstone mode and interaction with internal phonons. PMID- 9946478 TI - Extended x-ray-absorption fine-structure study of hydrogenated amorphous silicon germanium alloys. I. Analysis based on spherical waves of photoelectrons. PMID- 9946479 TI - Extended x-ray-absorption fine-structure study of hydrogenated amorphous silicon germanium alloys. II. Dependence of bond length and coordination on composition. PMID- 9946480 TI - Hot-carrier energy-loss rates in GaAs/AlxGa PMID- 9946481 TI - Deep-level-noise spectroscopy of ion-implanted polysilicon thin films. PMID- 9946482 TI - Nonlocal theory of thermal conductivity. PMID- 9946484 TI - Bound-exciton states of multiple-quantum-well structures in external fields. PMID- 9946483 TI - Structural and electronic properties of bulk GaAs, bulk AlAs, and the (GaAs)1(AlAs)1 superlattice. PMID- 9946485 TI - Temperature dependence of vicinal Si(111) surfaces. PMID- 9946487 TI - Special points for superlattices and strained bulk semiconductors. PMID- 9946486 TI - Theory of resonant tunneling in heterostructures. PMID- 9946488 TI - Time-resolved far-infrared magnetospectroscopy of hydrogenlike impurities in III V semiconductors. PMID- 9946489 TI - Successive phase transitions in the linear-chain semiconductor (NbSe4)3I studied by Raman scattering and electrical resistivity. PMID- 9946490 TI - Ballistic electron transmission through interfaces. PMID- 9946491 TI - Electronic structure of (InAs)m(GaAs)m (m=1-7) strained superlattices. PMID- 9946492 TI - Conductivity response of nonthermal hot carriers photoexcited by subpicosecond pulses in GaAs. PMID- 9946494 TI - Depletion regions and electronic surface states in doped semiconductor superlattices. PMID- 9946493 TI - Effect of sample doping level during etching of silicon by fluorine atoms. PMID- 9946495 TI - Three-dimensional numerical simulations for activated hopping conduction. PMID- 9946497 TI - Low-temperature specific heat of glasses: Temperature and time dependence. PMID- 9946496 TI - Oxygen vacancies and defect electronic states on the SnO2(110)-1 x 1 surface. PMID- 9946499 TI - Secondary-electron effects in photon-stimulated desorption. PMID- 9946498 TI - Corrections to the continuum approximation of the Frohlich polaron: The ground state energy. PMID- 9946500 TI - Interband transitions and core excitation in highly oriented pyrolytic graphite studied by inelastic synchrotron x-ray scattering: Band-structure information. PMID- 9946502 TI - Characterization of a nitrogen center in high-purity SiO2:OH glass. PMID- 9946501 TI - Low-temperature behavior of krypton monolayers on graphite. PMID- 9946503 TI - Energetics and lattice relaxation of light impurities in aluminum. PMID- 9946504 TI - Vibration modes of adsorbed fractal arrangements of atoms. PMID- 9946505 TI - New procedure for evaluating a large number of continued-fraction parameters in periodic structures. PMID- 9946507 TI - Cooling of hot carriers in highly photoexcited semiconductors. PMID- 9946506 TI - Exact k-q solution for a Bloch electron in a constant electric field. PMID- 9946508 TI - Optical absorption of ZnGa2Se PMID- 9946509 TI - Effect of lattice vibrations on scanning-tunneling-microscope images of graphite. PMID- 9946510 TI - Electronic spectroscopy of zero-dimensional systems. PMID- 9946512 TI - Density of states and energy spectra of hydrogenic impurities in quantum-well wires. PMID- 9946511 TI - Local-density-pseudofunction theory of bulk Si. PMID- 9946514 TI - Erratum: Electron states in n-type inversion layers with periodic microstructure PMID- 9946513 TI - Long-wavelength optic vibrations in a superlattice. PMID- 9946515 TI - Evidence for solute segregation on Cu-Mn alloy surfaces studied by low-energy ion scattering. PMID- 9946516 TI - Role of adsorption site on electron-energy-loss cross sections of single-layer substrate modes. PMID- 9946517 TI - Doubly and triply resonant Raman scattering by LO phonons in GaAs/AlAs superlattices. PMID- 9946518 TI - Experimental studies of the nu =1/5 hierarchy in the fractional quantum Hall effect. PMID- 9946519 TI - Ultrahigh electron and hole mobilities in zero-gap Hg-based superlattices. PMID- 9946520 TI - Raman intensities for collective excitations of a layered electron gas. PMID- 9946521 TI - Anisotropy and infrared response of the GaAs-AlAs superlattice. PMID- 9946522 TI - Nonlinear electric transport and switching phenomenon in the mixed-stack charge transfer crystal tetrathiafulvalene-p-chloranil. PMID- 9946523 TI - Mechanisms of recoil ejection of Ni+ ions from a Ni(100) surface. PMID- 9946524 TI - Electron-impact ionization in crystals. PMID- 9946525 TI - Derivation of the resonance frequency from the free energy of ferromagnets. PMID- 9946526 TI - Broadening of a resonant absorption line in the presence of simultaneous ion-ion and ion-electron relaxations: A first application of the continuous moments method. PMID- 9946527 TI - Simulation of the polarizable-ion dynamics of Rb2ZnCl PMID- 9946528 TI - Quantum reflection in the presence of dissipation. PMID- 9946529 TI - Order and disorder in pure and doped KTaO3: A 181Ta NMR study. PMID- 9946530 TI - Amorphous phase formation in Mn-implanted Al films and single crystals. PMID- 9946531 TI - Theory of deep inelastic neutron scattering: Hard-core perturbation theory. PMID- 9946532 TI - X-ray and neutron scattering from rough surfaces. PMID- 9946533 TI - Thermal conductivity and ultrasonic attenuation in heavy-fermion superconductors. PMID- 9946534 TI - Upper critical fields of periodic and quasiperiodic Nb-Ta superlattices. PMID- 9946535 TI - Superconducting properties of VNx sputtered films including spin fluctuations and radiation damage of stoichiometric VN. PMID- 9946537 TI - Magnetic properties of anisotropic superconductors. PMID- 9946536 TI - Dimensional phase transition in superconductors with short coherence length. PMID- 9946538 TI - Effects of ion irradiation on the normal state and superconducting properties of NbN thin films. PMID- 9946539 TI - Superfluid 3He in very confined regular geometries. PMID- 9946540 TI - Thermal enhancement of macroscopic quantum tunneling: Derivation from noise theory. PMID- 9946542 TI - Upper critical fields of superconductor-ferromagnet multilayers. PMID- 9946541 TI - Electronic structure of LiBeH3. PMID- 9946544 TI - Three-dimensional vortex dynamics in superfluid 4He: Homogeneous superfluid turbulence. PMID- 9946543 TI - Surface tension of a Fermi liquid. PMID- 9946545 TI - Monte Carlo study of 4He in two dimensions. PMID- 9946546 TI - Structural implications of nuclear electric quadrupole splittings in high-Tc superconductors. PMID- 9946547 TI - Synthesis and characterization of YBa2(Cu1-xMx)3O7- delta (M=Co,Ni): Crystal symmetry, superconductivity, and the role of oxygen. PMID- 9946548 TI - Vortex lattice structure in uniaxial superconductors. PMID- 9946549 TI - X-ray photoelectron investigation of the valence-band electronic structure of superconducting Y-Ba-Cu oxide. PMID- 9946550 TI - Orthorhombic-to-tetragonal transition in R1+xBa2-xCu3O7+ delta (R=Nd, Sm, and Eu). PMID- 9946552 TI - Systematic Raman study of effects of rare-earth substitution on the lattice modes of high-Tc superconductors. PMID- 9946551 TI - Meissner effect and critical fields in an inhomogeneous Ba2HoCu3O7-x high-Tc superconductor. PMID- 9946553 TI - Coupled even-parity superconducting states. PMID- 9946554 TI - Normal-state transport parameters of epitaxial thin films of YBa2Cu3O7- delta. PMID- 9946555 TI - Antiferromagnetism in YBa2Cu PMID- 9946556 TI - Effect of Fe on the superconductivity of the Ba-Y-Cu oxide system. PMID- 9946557 TI - Phenomenology of high-Tc oxides: New kind of anisotropic superconductors. PMID- 9946558 TI - Coupled-spin-mobile-hole model for high-Tc superconducting oxides. PMID- 9946559 TI - Origin of the 110-K superconducting transition in the Bi-Sr-Ca-Cu-O system. PMID- 9946560 TI - Assignment of prototype symmetry for the Y-Ba-Cu-O superconductor and some predictions based on this assignment. PMID- 9946561 TI - Total dielectric function: Algebraic sign, electron-lattice response, and superconductivity. PMID- 9946563 TI - Diamagnetism of percolative granular superconductors and diluted Josephson arrays. PMID- 9946562 TI - Response functions and collective modes of 3He in strong magnetic fields: Determination of material parameters from experiments. PMID- 9946564 TI - Phase diagram of the lattice superconductor. PMID- 9946565 TI - Effect of intersite band hybridization and on-site correlation on the magnetism of localized-moment systems. PMID- 9946566 TI - Heisenberg and Potts spin glasses: A renormalization-group study. PMID- 9946567 TI - Irradiation-induced formation of metastable phases: A master-equation approach. PMID- 9946568 TI - Cluster simulation of the lattice Anderson model. PMID- 9946569 TI - Size effects in phase-transition kinetics. PMID- 9946570 TI - Incipient magnetic order in CeCu6. PMID- 9946572 TI - Partially ordered states in Ginzburg-Landau-Wilson models with cubic-type anisotropy. PMID- 9946571 TI - Ferromagnetism in the strongly correlated Hubbard model. PMID- 9946574 TI - Resonant band-electron-f-electron scattering theory for highly correlated actinide systems. PMID- 9946573 TI - Fractal pore space and rock permeability implications. PMID- 9946575 TI - Magnetic properties of amorphous mixed Ising spin systems in a transverse field. PMID- 9946577 TI - Equivalence of dynamics in ultrametric and hierarchical spaces. PMID- 9946576 TI - Scaling in the kinetics of the order-disorder transition in Ni3Mn. PMID- 9946578 TI - Reinvestigation of the reentrant spin-glass phase of Fe26Cr PMID- 9946579 TI - Glassy relaxation in the Fukuyama-Lee-Rice model of charge-density waves. PMID- 9946580 TI - Electron spin resonances in field-induced spin-density waves in Bechgaard salts. PMID- 9946582 TI - Dynamical scaling, domain-growth kinetics, and domain-wall shapes of quenched two dimensional anisotropic XY models. PMID- 9946581 TI - Crystal-field anisotropy in the magnetic susceptibility of single-crystal CfCl3. PMID- 9946583 TI - Power-law relaxation of spatially disordered stochastic cellular automata and directed percolation. PMID- 9946584 TI - Smooth Fourier interpolation of periodic functions. PMID- 9946585 TI - Interface kinetics of freezing and melting with a density change. PMID- 9946586 TI - Finite-size scaling of O(n) models in higher dimensions. PMID- 9946587 TI - Low-temperature dynamics of sine-Gordon solitons. PMID- 9946589 TI - Percolation renormalization-group approach to the q-state Potts model. PMID- 9946588 TI - Diffusion on a one-dimensional structure with hierarchical waiting-time distribution. PMID- 9946590 TI - Nature of paramagnetic centers in a-Si and a-Si:H. PMID- 9946591 TI - Ultrasonic attenuation due to Mn2+ spins in Zn1-xMnxSe and Cd1-xMnxTe at low temperatures. PMID- 9946592 TI - Irreducible-Green's-function theory of an anisotropic Heisenberg ferromagnet. PMID- 9946594 TI - Frenkel-Kontorova model with anharmonic interactions. PMID- 9946593 TI - Classical statistical mechanics of the nonlinearly polarizable shell-model chain for ferroelectric materials. PMID- 9946595 TI - Scaling analysis of the collapse of branched polymers. PMID- 9946596 TI - Magnetic properties of Fe-Mn-Al alloys in the disordered phase. PMID- 9946597 TI - Optical interband transitions in semi- and superconducting La2-xSrx PMID- 9946598 TI - Anomalous temperature dependence of the electric field gradient at the Y site in In0.1Y0.9Ba2Cu3O9- delta : Evidence for soft vibrational modes. PMID- 9946599 TI - Conduction and Hall measurements of Ba2YCu3O6+ delta films at high temperatures: The role of oxygen. PMID- 9946600 TI - Copper nuclear quadrupole resonance in GdBa2Cu3O7: Determination of site assignment. PMID- 9946601 TI - Hyperfine interaction studies of antiferromagnetic order in CuO. PMID- 9946602 TI - Metallic to variable-range-hopping transition controlled by oxygen content in La Sr-Cu-O. PMID- 9946603 TI - Anisotropy of the lower critical field, magnetic penetration depth, and equilibrium shielding current in single-crystal YBa2Cu3O7- delta. PMID- 9946604 TI - Kosterlitz-Thouless transition of fluxless solitons in superconducting YBa2Cu3O7- delta single crystals. PMID- 9946605 TI - Electrical resistivity and magnetic susceptibility in BiCaSrCu2Oy. PMID- 9946606 TI - Charge-transfer strings in the extended Hubbard model for copper oxide superconductors. PMID- 9946607 TI - Thermogravimetric study of the La1Ba2Cu3O7- delta system: The correlation of Tc with oxygen content. PMID- 9946609 TI - Superconformal invariance in the tricritical O(N) model. PMID- 9946608 TI - Critical magnetic susceptibility of gadolinium. PMID- 9946610 TI - Erratum: Melting and freezing of Lennard-Jones clusters on a surface PMID- 9946611 TI - Positional disorder in superconducting wire networks and Josephson junction arrays. PMID- 9946612 TI - NMR study of the time evolution of the fractal geometry of cement gels. PMID- 9946614 TI - Ground-state properties of the free surface of liquid 4He. PMID- 9946613 TI - Proposed NMR determination of the exchange parameters in hexagonal-close-packed 3He. PMID- 9946615 TI - Positron annihilation study of Y-Ba-Cu-O high-Tc superconductors. PMID- 9946618 TI - Thermal conductivity of YBa2Cu3O7- delta below 1 K: Evidence for normal-carrier transport well below Tc. PMID- 9946616 TI - Spin dynamics in the Cu(2)-O planes of tetragonal and orthorhombic YBa2Cu3O7- delta as probed by 89Y NMR. PMID- 9946617 TI - Observation of oxygen-vacancy-ordered domains in oxygen-deficient single-crystal YBa2Cu3O6.7. PMID- 9946619 TI - Observation of orthorhombic-tetragonal phase equilibria in YBa2Cu3-xFexO7- delta. PMID- 9946620 TI - Synthesis and superconducting critical temperature of YBa2Cu PMID- 9946621 TI - Anomalously large Tc depression by Zn substitution in Y-Ba-Cu-O. PMID- 9946622 TI - Lattice dynamics of the high-Tc superconductor YBa2Cu PMID- 9946623 TI - Electronic properties of Ba2Y1-xPrxCu3O7- delta. PMID- 9946624 TI - High-temperature Raman measurements of single-crystal YBa2Cu PMID- 9946625 TI - Strongly anisotropic electrical properties of single-crystal YBa2Cu3O7-x. PMID- 9946627 TI - SU(2) gauge invariance and order parameters in strongly coupled electronic systems. PMID- 9946626 TI - 1/f-noise-power measurements of copper oxide superconductors in the normal and superconducting states. PMID- 9946628 TI - X-ray spectroscopy of EuBa2(Cu1-yZny)3O7-x: Suppression of superconductivity. PMID- 9946629 TI - Upper critical magnetic fields of pure and thoriated UBe13. PMID- 9946630 TI - Occurrence of chaotic transients during transitions between quasiperiodic states in yttrium iron garnet. PMID- 9946632 TI - Ferromagnetic enhancement in the hexagonal Ce(Rh1-xIrx)3B2 system. PMID- 9946631 TI - New configurations of rare-earth superlattices. PMID- 9946633 TI - Multifractal analysis of eigenstates in systems with off-diagonal disorder. PMID- 9946634 TI - Growth and thermal stability of Ag or Au films on Nb(110). PMID- 9946635 TI - Physisorption interaction of H2 with noble-metal surfaces: A new H2-Cu potential. PMID- 9946637 TI - Influence of H-C bonds on the stopping power of hard and soft carbonized layers. PMID- 9946636 TI - Effective potentials in density-functional theory. PMID- 9946638 TI - Voltage fluctuations in multilead devices. PMID- 9946639 TI - Voltage fluctuations in mesoscopic metal rings and wires. PMID- 9946640 TI - Theory of electronic structure and magnetic behavior of fcc iron grown on Cu(001). PMID- 9946642 TI - Empty electronic states of graphite and the growth of Au and Pd clusters. PMID- 9946641 TI - Formation rate of muonic molecules in an alloy of deuterium and tritium. PMID- 9946643 TI - Spectrum of surface-mode contributions to the differential energy-loss probability for electrons passing by a spheroid. PMID- 9946645 TI - Electrically driven metal-insulator transition in layered transition-metal dichalcogenides. PMID- 9946644 TI - Diffusion path and Haven's ratio of mobile ions in alpha -Ag2Te. PMID- 9946646 TI - Discrete valence-electron states for Na overlayers on Cu(111). PMID- 9946647 TI - Shear horizontal acoustic surface shape resonances. PMID- 9946648 TI - Evolution of a molecular exciton on a Davydov lattice at T=0. PMID- 9946649 TI - Auger neutralization rates of multiply charged ions near metal surfaces. PMID- 9946650 TI - Internal strain and dynamic effective charges in CuCl and CuBr. PMID- 9946652 TI - Phase singularities and quantum dynamics. PMID- 9946651 TI - Coupling of H vibration to substrate electronic states in Mo(100)-p(1 x 1)H and W(100)-p(1 x 1)H: Example of strong breakdown of adiabaticity. PMID- 9946653 TI - Correlation effects in photoemission from adsorbates: Hydrogen on narrow-band metals. PMID- 9946654 TI - Electron-momentum distribution in zirconium. PMID- 9946655 TI - Potassium graphite under pressure: Optical reflectivity of superdense phases. PMID- 9946657 TI - Phonon calculations in superperiodic structures: The surface Green-function matching approach. PMID- 9946656 TI - Branching ratio in x-ray absorption spectroscopy. PMID- 9946658 TI - Interaction, electron transfer, and work function of a chemisorbed alkali-metal submonolayer on a W(001) surface. PMID- 9946659 TI - Isochronal annealing of proton- or alpha -particle-irradiated Cu3Au at low temperatures. PMID- 9946660 TI - Density-functional formulation of the generalized pseudopotential theory. III. Transition-metal interatomic potentials. PMID- 9946661 TI - Boundary scattering and weak localization of electrons in a magnetic field. PMID- 9946662 TI - Theoretical study of the influence of quantum size effects and tunnel-barrier structure on the tunneling current in metal-semiconductor-metal junctions. PMID- 9946663 TI - Theoretical study of tunneling phenomena in double-barrier quantum-well heterostructures. PMID- 9946665 TI - Anomalous values of interaction constants in the two-dimensional electron gas of a silicon metal-oxide-semiconductor field-effect transistor measured by parallel- and perpendicular-field magnetoconductivity. PMID- 9946664 TI - Direct-energy-gap dependence on Al concentration in AlxGa PMID- 9946666 TI - Large- versus small-lattice-relaxation models of the DX centers in Ga1-xAlxAs. PMID- 9946668 TI - Larmor clock reexamined. PMID- 9946667 TI - Internal-stress effects on Raman spectra of InxGa PMID- 9946669 TI - Multielectron excitations in x-ray-absorption spectra of a-Si:H. PMID- 9946671 TI - Nonreciprocal propagation and localization of plasmons by a magnetic field in finite semiconductor n-i-p-i superlattices. PMID- 9946670 TI - Surface phonons in Si(111) + H(1 x 1). PMID- 9946673 TI - Study of compensation in insulating and metallic n-type CdSe using transport measurements. PMID- 9946672 TI - Proposed universal interatomic potential for elemental tetrahedrally bonded semiconductors. PMID- 9946674 TI - Energy and vibrational spectrum of the Si(111) (7 x 7) surface from empirical potentials. PMID- 9946676 TI - Energy levels of excitonic molecules. PMID- 9946675 TI - Effective Bloch equations for semiconductors. PMID- 9946677 TI - Influence of the resonant acceptor state on the magnetotransport properties of zero-band-gap Hg1-xMnxTe. PMID- 9946678 TI - Raman-scattering and electron-microscopy study of composition-dependent ordering in metastable (AIIIBV)1-x(CIII2)x alloys. PMID- 9946679 TI - Effects of electronic coupling on the band alignment of thin GaAs/AlAs quantum well structures. PMID- 9946680 TI - Photoreflectance study of narrow-well strained-layer InxGa1-xAs/GaAs coupled multiple-quantum-well structures. PMID- 9946682 TI - Ionized-impurity scattering due to clusters of correlated impurities. PMID- 9946681 TI - Magnetooptical investigations and four-wave-mixing spectroscopy of PbSe. PMID- 9946683 TI - Electrical and optical properties of defects in silicon introduced by high temperature electron irradiation. PMID- 9946684 TI - Thermal diffuse low-energy electron diffraction on the Si(111)2 x 1 structure. PMID- 9946685 TI - Inversion-asymmetry-induced magnetooptical transitions in HgTe/CdTe superlattices. PMID- 9946687 TI - Magnetic breakdown and the de Haas-van Alphen effect in Hg1-xFexSe. PMID- 9946686 TI - L-valley-derived states in (001) GaSb/AlSb quantum wells and superlattices. PMID- 9946688 TI - Many-body effects in praesodymium core-level spectroscopies of PrO2. PMID- 9946690 TI - Spin-phonon interaction in small particles of MgO:Ni2+ PMID- 9946689 TI - Three-photon absorption spectra in KI and RbI. PMID- 9946692 TI - Weak-coupling magnetopolarons in a slab of a polar crystal. PMID- 9946691 TI - Band gap in NiO: A cluster study. PMID- 9946693 TI - Dispersion of the photoanisotropy induced in an FA(II) KCl:Li crystal. PMID- 9946695 TI - Theoretical model for the electrodiffusion of M+ (M=Li,Na,K) ions in a quartz crystal. PMID- 9946694 TI - Dynamical Jahn-Teller effect and fluorescence line narrowing of the 4A2-4T2 zero phonon transition in KZnF3:Cr. PMID- 9946696 TI - Investigation of intrinsic optical damage in potassium bromide at 532 nm. PMID- 9946697 TI - Optical dielectric function of high-stage potassium graphite intercalation compounds: Experiment and theory. PMID- 9946698 TI - Laser vaporization of solids into an inert gas: A measure of high-temperature cluster stability. PMID- 9946699 TI - Size-dependent change in the d bands of Cu particles. PMID- 9946700 TI - Electron mobility in quasi-one-dimensional conductors: A theoretical study. PMID- 9946701 TI - Numerical study of conductance fluctuations based on the Kubo formula. PMID- 9946702 TI - Radiative decay of excitons bound to chalcogen-related isoelectronic impurity complexes in silicon. PMID- 9946703 TI - Anomalous surface reconstruction: Observation of Si(111) 2 x 1 on sputtered and annealed Si(111) surfaces. PMID- 9946704 TI - Thin PMID- 9946705 TI - Correlation of scanning-tunneling-microscope image profiles and charge-density wave amplitudes. PMID- 9946706 TI - Magnetic-field dependence of PbTe-EuTe transistor characteristics. PMID- 9946708 TI - Vibronic coupling for substitutional iron impurities in ZnTe. PMID- 9946707 TI - Potential-well shape U(z)=U0||z/(Lz/2)||2/3 with the GaAs/AlxGa1-xAs system. PMID- 9946709 TI - Erratum: Electronic properties and superconductivity of rapidly quenched Al-Si alloys PMID- 9946710 TI - Photoemission yields of coldly deposited silver films. PMID- 9946711 TI - Electronic-structure method for general space-filling cell potentials. PMID- 9946712 TI - Configuration dependence of hopping matrix elements in the Anderson model. PMID- 9946713 TI - Long-range order and lattice mismatch in metallic superlattices. PMID- 9946714 TI - Possibility of LiBeH3 being metallic. PMID- 9946715 TI - Interaction phenomena between deep levels and minibands in semiconductor superlattices. PMID- 9946716 TI - Optical investigation of biexcitons and bound excitons in GaAs quantum wells. PMID- 9946718 TI - Breakdown of the virtual-crystal approximation in Ge2x(GaAs)1-x. PMID- 9946717 TI - Resonant photoluminescence studies of the growth-induced defects in GaAs grown by molecular beam epitaxy. PMID- 9946719 TI - Connection between the Meyer-Neldel relation and multiple-trapping transport. PMID- 9946721 TI - Low-temperature charge-density-wave dynamics. PMID- 9946720 TI - Symmetrically strained Si/Ge superlattices on Si substrates. PMID- 9946722 TI - Identification of a second energy level of EL2 in n-type GaAs. PMID- 9946724 TI - Theory of collective excitations in a two-dimensional array of quantum dots. PMID- 9946723 TI - Relevance of persistent photoconductivity in semi-insulating and n-type semiconducting GaAs to the charge state of metastable EL2 defects. PMID- 9946726 TI - Spin dynamics in the mixed-valence compound HgSe:Fe. PMID- 9946725 TI - Excitonic interaction in GaAs/Ga1-xAlxAs quantum wells. PMID- 9946727 TI - Quantized conductance of magnetoelectric subbands in ballistic point contacts. PMID- 9946728 TI - Optical multistability in a nonlinear Fibonacci multilayer. PMID- 9946729 TI - X-ray interference method for studying interface structures. PMID- 9946731 TI - 57Fe Mossbauer-effect study of preferential site occupancy in quasicrystalline Al86Cr PMID- 9946730 TI - Connection between spin-singlet and hierarchical wave functions in the fractional quantum Hall effect. PMID- 9946732 TI - Chemical potential and carrier density in bismuth thin films under three dimensional quantizations. PMID- 9946734 TI - Bonding and magnetism in Fe-M (M=B,C,Si,N) alloys. PMID- 9946733 TI - Orientational order in dense random sphere packings. PMID- 9946735 TI - Electron-stimulated desorption of O+ ions from a gas-covered CdS(0001) surface. PMID- 9946736 TI - X-ray photoemission and Auger-electron spectroscopic study of the electronic structure of intercalation compounds MxTiS2 (M=Mn, Fe, Co, and Ni). PMID- 9946737 TI - Heats of solution and lattice-expansion and trapping energies of hydrogen in transition metals. PMID- 9946738 TI - Instability of quasicrystalline order in the local Kalugin-Kitaev-Levitov model. PMID- 9946739 TI - Extended appearance-potential fine-structure measurements of clean and oxidized iron surfaces. PMID- 9946741 TI - Electronic structure of KHgC4 and related materials. PMID- 9946740 TI - Local-field effects in Langmuir-Blodgett films of hemicyanine and behenic acid mixtures. PMID- 9946742 TI - Electronic structure of a modulation-doped spherical semiconductor heterostructure with mesoscopic dimensions. PMID- 9946743 TI - Electronic structure of small metal clusters: Thomas-Fermi statistical theory. PMID- 9946744 TI - Influence of electromagnetic field variations on the surface-effect mechanisms of photofield emission. PMID- 9946746 TI - High-energy-spectroscopy study of the Pd-Ce system. PMID- 9946745 TI - Short-range structure of Al-Mn and Al-Mn-Si aperiodic alloys. PMID- 9946747 TI - Linear ac response of a depinned charge-density wave. PMID- 9946748 TI - Thermopower and resistivity of amorphous metallic In-Sb near the metal-insulator transition. PMID- 9946749 TI - Structures and adsorption energies of commensurate rare-gas monolayers on MgO(100). PMID- 9946750 TI - Cluster coherent-potential approximation in ternary random alloys. PMID- 9946751 TI - Calculation of surface-polaron ground-state energy and effective potential. PMID- 9946752 TI - Total and surface density of states on the Bethe lattice. PMID- 9946754 TI - Simulated annealing with floating Gaussians: Hellmann-Feynman forces without corrections. PMID- 9946753 TI - Growth and characterization of epitaxial bismuth films. PMID- 9946756 TI - Single-impurity model for charge-density-wave dynamics. PMID- 9946755 TI - Electron-gas self-energy at metallic density. PMID- 9946758 TI - Photoemission spectra and band structures of simple metals. PMID- 9946757 TI - Self-consistent solution of the Kahana equation for a positron in an electron gas. PMID- 9946759 TI - Consistent treatment for a single electron in a thermal crystal with an applied electric field. PMID- 9946760 TI - c(2 x 2)S/Cr(001) surface and near-surface structure determined using angle resolved photoemission extended fine structure. PMID- 9946761 TI - Rate equations for dynamic processes at solid surfaces: Competition between charge transfer and thermalization of the adatom-metal-surface bond. PMID- 9946762 TI - Electronic structure of the light-impurity (boron)-vacancy complex in iron. PMID- 9946764 TI - Diffraction from domain-wall systems. PMID- 9946763 TI - Two-dimensional resonant tunneling. PMID- 9946765 TI - Core-level study of the phase transition on the Ge(111)-c(2 x 8) surface. PMID- 9946766 TI - Biexcitonic nonlinearity in GaAs/GaxAl1-xAs quantum wells and quantum-well wires. PMID- 9946767 TI - Photoemission studies of the reactions of ammonia and N atoms with Si(100)-(2 x 1) and Si(111)-(7 x 7) surfaces. PMID- 9946768 TI - Thermal and electron-beam-induced reaction of disilane on Si(100)-(2 x 1). PMID- 9946769 TI - Composition dependence of the Gamma 8- Gamma 6 transition in mercury cadmium telluride: A reexamination. PMID- 9946770 TI - Mechanism for photogeneration of metastable charged solitons in polyacetylene. PMID- 9946771 TI - Atomic configuration and electronic properties of the metastable state of the EL2 center in GaAs. PMID- 9946772 TI - Metastable conduction states in Mo2S3: Pulse conductivity and thermoelectric power. PMID- 9946774 TI - Resonant tunneling via Landau levels in GaAs-Ga1-xAlxAs heterostructures. PMID- 9946773 TI - Covalent and metallic bonding within the quasi-ion approach. PMID- 9946775 TI - Microscopic structure of the NL10 heat-treatment center in silicon: Study by electron-nuclear double resonance. PMID- 9946777 TI - Surface-structure analysis of Au overlayers on Si by impact-collision ion scattering spectroscopy: sqrt 3 x sqrt 3 and 6 x 6 Si(111)/Au. PMID- 9946776 TI - Excitonic molecule with electron-hole exchange interaction. PMID- 9946778 TI - Theory of quasiparticle surface states in semiconductor surfaces. PMID- 9946779 TI - Interference effects in nonlinear charge-density-wave dynamics. PMID- 9946780 TI - Second-order nonlinear effects in asymmetric quantum-well structures. PMID- 9946781 TI - Synthesis of diamonds by use of microwave plasma chemical-vapor deposition: Morphology and growth of diamond films. PMID- 9946782 TI - Phonon ionization of neutral donors in lightly doped GaAs: A model for the conductance oscillations in semiconductor-insulator-semiconductor tunnel structures. PMID- 9946784 TI - First- and second-nearest-neighbor divacancies in silicon: Origin and ordering of gap levels. PMID- 9946783 TI - Impurity states in a polar-crystal slab. PMID- 9946785 TI - Photoluminescence line shape in degenerate semiconductor quantum wells. PMID- 9946787 TI - Percolation threshold of thermal conduction in AxIVB PMID- 9946786 TI - Effect of Fe on the conduction band of HgSe. PMID- 9946788 TI - Plasmon- and phonon-assisted recombinations in germanium. PMID- 9946789 TI - Energy-resolved study of the spin precession in photoemission from activated (110) GaAs. PMID- 9946790 TI - Time-resolved recombination dynamics of photoionized hydrogenlike impurities. PMID- 9946792 TI - Evolution of the electronic structure of polyacetylene and polythiophene as a function of doping level and lattice conformation. PMID- 9946791 TI - Zeeman spectroscopy of the defect-induced bound-exciton lines in GaAs grown by molecular-beam epitaxy. PMID- 9946794 TI - Sequential resonant tunneling characteristics of AlAs/GaAs multiple-quantum-well structures. PMID- 9946793 TI - Infrared absorption studies of the divacancy in silicon: New properties of the singly negative charge state. PMID- 9946795 TI - Surface magnetoplasmon polaritons in truncated semiconductor superlattices. PMID- 9946796 TI - Magnetoplasmon-phonon coupling in a GaxIn PMID- 9946797 TI - Screening properties of the two-dimensional electron gas in the quantum Hall regime. PMID- 9946798 TI - Optical and analytical transmission-electron-microscopy studies of thermochemically reduced MgO crystals. PMID- 9946800 TI - Three-photon spectroscopy of excitons and polaritons in alkali halides. PMID- 9946799 TI - Dependence of the covalency of the (MnF6)4- complex ion upon the Mn2+-F- distance. PMID- 9946801 TI - Fourth-order relaxation processes in crystalline CO2. PMID- 9946802 TI - Chemical dependence of the multiple-tip effect in scanning tunneling microscopy. PMID- 9946803 TI - Self-consistent Sommerfeld droplet as a simple model for an accurate prediction of the electronic properties of small metal particles. PMID- 9946804 TI - Virial test of the interpolation formulas for the correlation energy of a paramagnetic electron liquid. PMID- 9946805 TI - Magnetoplasmons and the repeated magnetoroton spectrum. PMID- 9946807 TI - Relation of resonant Raman line shape to electronic structure in quantum wells. PMID- 9946806 TI - Quasi-two-dimensional electron gas in a cylindrical quantum well under a strong magnetic field. PMID- 9946808 TI - Dynamical group SO(3,2;r) of the polariton waves. PMID- 9946810 TI - Comments on the calculation of the thermodynamic properties of metals at high temperatures. PMID- 9946809 TI - Validity of the recursion method for calculating the energy gap of (GaAs)1-xGe2x: Comments on a paper by Gu, Newman, and Fedders. PMID- 9946811 TI - Bulk-plasmon-enhanced photoemission from Nb(100) surface resonances. PMID- 9946812 TI - Interpretation of the complete excitation spectrum for pinned charge-density waves. PMID- 9946813 TI - Picosecond infrared spectroscopy of hot carriers in a modulation-doped Ga0.47In0.53As multiple-quantum-well structure. PMID- 9946815 TI - Determination of valence-band effective-mass anisotropy in GaAs quantum wells by optical spectroscopy. PMID- 9946814 TI - Resonant-tunneling conductivity in one-dimensional disordered systems. PMID- 9946816 TI - Far-infrared study of confinement effects on acceptors in GaAs/AlxGa1-xAs quantum wells. PMID- 9946817 TI - Boundary conditions and interface states in heterostructures. PMID- 9946818 TI - Second-harmonic generation in submicrometer GaAs-AlxGa PMID- 9946819 TI - Thermoelectric power and thermal conductivity of first-stage graphite-acceptor intercalation compounds. PMID- 9946820 TI - Structure of a (RhCl6)4- defect in AgCl. PMID- 9946822 TI - Optical generation and bottlenecking of nonzero-wave-vector magnons via Er3+ centers in antiferromagnetic MnF2. PMID- 9946821 TI - Planar channeling radiation from 54-110-MeV electrons in diamond and silicon. PMID- 9946823 TI - Electronic structure, hyperfine interactions, and radial densities in the Fe1+ tetrahedral sulfide as calculated by the multiple-scattering method. PMID- 9946824 TI - Sign of the hyperfine parameters of anomalous muonium in diamond. PMID- 9946825 TI - Collapse of Mossbauer spectra in strong applied radio-frequency fields. PMID- 9946826 TI - Dechanneling and stopping power of relativistic channeled particles. PMID- 9946827 TI - Deuteron magnetic resonance in tantalum, niobium, and vanadium deuterides. PMID- 9946828 TI - Electronic structure investigated by NMR and superconductivity of cubic Laves phase hydrides: V2HfHx (0 <= x <= 4.5) and V2Hf0.5Zr0.5Hx (0 <= x <= 4.8). PMID- 9946829 TI - Perturbative results for the short-range order parameter, specific heat, and resistivity of granular superconductors. PMID- 9946830 TI - Determination of the zeroth moment of the effective roton-maxon interaction in liquid He II. PMID- 9946833 TI - Explanation of the phase diagram of beta -di PMID- 9946832 TI - High-resolution second-sound velocity measurements near the lambda point of helium. PMID- 9946831 TI - Magnetization and peak effect of several single crystals of V3Si. PMID- 9946834 TI - Neutron scattering study of the heavy-fermion compound CeRu2Si2. PMID- 9946835 TI - Superconducting and normal-state properties of MoNx thin films. PMID- 9946836 TI - Multiple-spin-exchange calculation of the T=0 properties of solid 3He. PMID- 9946837 TI - Quasiclassical theory of superconductivity near magnetically active interfaces. PMID- 9946838 TI - Shadow wave function for many-boson systems. PMID- 9946839 TI - Spin-dependent correlations in the ground state of liquid 3He. PMID- 9946840 TI - Hole polaron propagation and pairing in a model for doped CuO2. PMID- 9946841 TI - Mechanism for high-temperature superconductivity. PMID- 9946843 TI - New coherent states in periodic arrays of ultrasmall Josephson junctions. PMID- 9946842 TI - Lack of Cu3+, Pb4+, and Bi5+ ions in metallic and superconducting oxides. PMID- 9946844 TI - Effect of Mn on the superconductivity of YBa2Cu3O7- delta. PMID- 9946845 TI - Charge-transfer mechanisms for high-Tc superconductivity. PMID- 9946846 TI - Evidence of nonphononic superconductivity in Nb3Ge. PMID- 9946847 TI - Electron-spin-resonance studies of the Ag-, Eu-, and Gd-doped Y-Ba-Cu-O high-Tc superconductors. PMID- 9946849 TI - Intrinsic multipeak structure in quasiparticle tunneling conductance of high-Tc superconductors. PMID- 9946848 TI - Superconducting properties of La2-xBax PMID- 9946850 TI - Experimental study of La1Ba2Cu3Ox. PMID- 9946851 TI - Neutron spectroscopic determination of the crystalline electric field in HoBa2Cu3O7- delta. PMID- 9946852 TI - Wigner-Seitz local-environment study of the high-Tc superconductors. PMID- 9946853 TI - Electronic structure of CuO2 sheets and spin-driven high-Tc superconductivity. PMID- 9946854 TI - Evidence for anisotropic pairing in YBa2Cu3O7- delta from the Landau theory of fluctuation specific heat. PMID- 9946855 TI - Valence bands, oxygen in planes and chains, and surface changes for single crystals of M2CuO4 and MBa2Cu3Ox (M=Pr,Nd,Eu,Gd). PMID- 9946856 TI - Stability of fluxon motion in long Josephson junctions at high bias. PMID- 9946857 TI - Spin-exchange and dipole relaxation rates in atomic hydrogen: Rigorous and simplified calculations. PMID- 9946858 TI - Dynamic symmetry breaking in mixed-valence systems. PMID- 9946859 TI - Interfacial wetting transition in a model with competing multispin interactions. PMID- 9946860 TI - Monte Carlo method for the Ising model in a transverse field. PMID- 9946861 TI - Susceptibility and specific-heat studies on the directionally anisotropic Heisenberg antiferromagnets. PMID- 9946863 TI - Diffusion of spin order in inhomogeneous systems. PMID- 9946862 TI - Early stages of spinodal decomposition for the Cahn-Hilliard-Cook model of phase separation. PMID- 9946864 TI - Conductance fluctuations in disordered systems: Dependence on the degree of disorder. PMID- 9946865 TI - Domain-growth kinetics for the Q-state Potts model in two and three dimensions. PMID- 9946867 TI - Metastability of the uniform magnetization in three-dimensional random-field Ising model systems. I. Fe0.7Mg PMID- 9946868 TI - Metastability of the uniform magnetization in three-dimensional random-field Ising model systems. II. Fe0.47Zn PMID- 9946866 TI - Trapping problem on a line with a dichotomous disorder. PMID- 9946870 TI - Metal-spin-density-wave transition in a quasi-one-dimensional conductor: Pressure and magnetic field effects. PMID- 9946869 TI - Universality in two- and three-dimensional growth and deposition models. PMID- 9946872 TI - Effect of simultaneous heavy-ion and electron bombardment on the amorphization kinetics of intermetallics. PMID- 9946871 TI - Neutron scattering study of spin fluctuations in Y(Mn1-xAlx PMID- 9946873 TI - Magnetic properties of thin Pd1-yNiy PMID- 9946874 TI - Dynamics of kink-kink collisions in the double-sine-Gordon system. PMID- 9946875 TI - Thermodynamic description of depolarized light scattering from viscoelastic liquids. PMID- 9946878 TI - Modulated order in classical magnetoelastic chains. PMID- 9946876 TI - NbTe4: A model for a class of incommensurate-to-incommensurate phase transitions. PMID- 9946877 TI - Low-temperature properties of the PMID- 9946879 TI - Current oscillations in near-commensurate systems. PMID- 9946880 TI - Finite-temperature band theory of ferromagnetic-antiferromagnetic interfaces including exchange anisotropy. PMID- 9946881 TI - Linear spin-(1/2 magnetic chains: Susceptibilities, correlation functions, and applications to (C6H11NH3)CuBr3 and deuterated CuCl2 PMID- 9946882 TI - Mean-field Potts glass model: Initial-condition effects on dynamics and properties of metastable states. PMID- 9946884 TI - Localization of phonons in mixed crystals. PMID- 9946885 TI - Renormalization-group analysis of chiral transitions. PMID- 9946883 TI - Theory of auto-oscillations in high-power ferromagnetic resonance. PMID- 9946886 TI - Scaling of splay and total rigidity for elastic percolation on the triangular lattice. PMID- 9946887 TI - Spin excitations in multilayered ferromagnetic electron gases. PMID- 9946889 TI - Modeling of phase diagrams for bcc magnetic alloys. PMID- 9946888 TI - Series study of random animals in general dimensions. PMID- 9946890 TI - Critical dynamics of metallic spin glasses. PMID- 9946892 TI - Transfer-matrix scaling for anomalous dynamics of a vector spin-glass chain. PMID- 9946891 TI - Crystallization and melting in metal-semiconductor multilayers. PMID- 9946893 TI - Josephson effect and Anderson's theorem. PMID- 9946894 TI - Direct evidence for ambient-controlled hopping conduction in inhomogeneous a-Si and a-Si:H from gas-diffusion experiments. PMID- 9946895 TI - Energy distribution of electrons excited in solids by moving particles. PMID- 9946897 TI - Electron-energy-loss spectroscopy of cleaved single-crystal YBa2Cu3O7-x. PMID- 9946896 TI - Effect of oxygen stoichiometry on softening of Raman active lattice modes in YBa2Cu3Ox. PMID- 9946898 TI - Spin-singlet pairing mechanism in magnon-pairing theories. PMID- 9946899 TI - Microwave study of YBa2Cu PMID- 9946900 TI - Optical reflectivity studies of polycrystalline La4BaCu PMID- 9946901 TI - Simple model for the Hall effect in YBa2Cu PMID- 9946902 TI - Electronic band properties of CaSr2Bi PMID- 9946904 TI - Two-carrier percolation model of normal-state transport properties of single crystal YBa2Cu3O7-x. PMID- 9946903 TI - Zero resistance at 107 K in the (Bi,Pb)-Ca-Sr-Cu oxide system. PMID- 9946905 TI - Identification of a superoxide in superconducting La2CuO4+ delta by x-ray photoelectron spectroscopy. PMID- 9946906 TI - Oxygen isotope effect on critical temperature and phonon modes in YBa2Cu3O7. PMID- 9946907 TI - Transmission-electron-microscopy study of high-temperature superconducting phases in the Tl-Ba-Ca-Cu-O system. PMID- 9946908 TI - Superconducting properties of a 27-A PMID- 9946909 TI - Experimental features of the antiferromagnetism in Ba2GdCu3O7-y. PMID- 9946910 TI - Bond-percolation threshold and lattice structure. PMID- 9946911 TI - Interaction energy of disclinations in pentagonal quasicrystals. PMID- 9946912 TI - Critical exponents of the gauge glass. PMID- 9946914 TI - Free-electron-like Stoner excitations in Fe. PMID- 9946913 TI - Analytic approximation to the ground-state energy of the Anderson model. PMID- 9946915 TI - Kinetic behavior and memory effect in the lock-in phase of A2BX4 incommensurate ferroelectric compounds. PMID- 9946916 TI - Comment on "Multicritical behavior of a square-lattice-gas model with anisotropic repulsive interactions: A transfer-matrix scaling study" PMID- 9946918 TI - Erratum: Theory of charge-imbalance relaxation in anisotropic heavy-fermion superconductors PMID- 9946917 TI - Equivalences between a dimer, a vertex, and a spin model. PMID- 9946919 TI - Erratum: High-field magnetoconductivity of electrons on hydrogen PMID- 9946921 TI - Channeling measurement of solute vibration amplitude in an alloy. PMID- 9946920 TI - T4 to T2 resistivity transition and superconducting fluctuations in disordered VN films. PMID- 9946922 TI - Temporal fluctuations of multiply scattered light in a random medium. PMID- 9946924 TI - Simple theory of the reverse ac Josephson effect. PMID- 9946923 TI - Optical anisotropy of YBa2Cu3O7-x. PMID- 9946925 TI - Inhomogeneous excited states in superconductors. PMID- 9946926 TI - Zero-temperature properties of the two-dimensional Heisenberg antiferromagnet: A numerical study. PMID- 9946927 TI - X-ray-photoelectron-spectroscopy evidence for peroxide in 1:2:3 copper oxides containing disordered or excess oxygen. PMID- 9946928 TI - Superconducting properties of single-crystal Bi2Sr PMID- 9946930 TI - Angular dependence of the upper critical field of Bi2.2Sr2Ca0.8Cu2O8+ delta. PMID- 9946929 TI - Calculated photoemission and x-ray emission spectra of Bi2Sr2CaCu2O8. PMID- 9946931 TI - Microwave collective transport in single-crystal Eu2CuO PMID- 9946933 TI - Effect of structural instability between 80 and 300 K on superconductivity of YBa2Cu PMID- 9946932 TI - Raman scattering from single crystals of the 84-K superconductor Bi2.2Ca0.8Sr2Cu2O8+ delta. PMID- 9946934 TI - Thermal recovery of oxygen-deficient superconducting YBa2Cu PMID- 9946935 TI - Optical and electrical properties of an organic superconductor di PMID- 9946936 TI - Effect of microstructure on positron-annihilation parameters in YBa2Cu3O7. PMID- 9946937 TI - Oxygen-vacancy ordering and microstructure in annealed YBa2Cu3O7- delta superconductors. PMID- 9946938 TI - Two-band model for anisotropic Hall effect in high-Tc Y-Ba-Cu-O. PMID- 9946939 TI - Electronic band properties of Ba2Tl PMID- 9946940 TI - Superexchange mechanism and d-wave superconductivity. PMID- 9946942 TI - Charging effects in coupled superconducting tunnel junctions and their implications for tunneling measurements of high-Tc superconductors. PMID- 9946941 TI - Photoemission study of a high-Tc superconducting Bi-Sr-Ca-Cu oxide. PMID- 9946944 TI - Low-frequency dynamics of orientational glasses. PMID- 9946943 TI - Coherent phase slip in arrays of underdamped Josephson tunnel junctions. PMID- 9946945 TI - Random perturbations to the ordered quantum antiferromagnetic ground state. PMID- 9946947 TI - Surface exponent in percolation and central-force percolation: A test for splay rigidity. PMID- 9946946 TI - Layer critical points of multilayer ethane adsorbed on graphite. PMID- 9946948 TI - Quasiperiodic anisotropic XY model. PMID- 9946949 TI - Two-dimensional Heisenberg antiferromagnet: Effect of anisotropy on the ground state. PMID- 9946951 TI - Interface roughening due to random impurities at low temperatures. PMID- 9946950 TI - Quasiequilibrium states of spin glasses. PMID- 9946952 TI - Spin-correlation function of the S=1 antiferromagnetic Heisenberg chain at T=0. PMID- 9946954 TI - Multilayer reconstruction of the W(001) surface. PMID- 9946953 TI - Theoretical spin- and angle-resolved photoemission spectra from Fe(110). PMID- 9946955 TI - Two-band character of the first-order longitudinal Hall effect. PMID- 9946956 TI - Effect of isotope concentration on the lattice parameter of germanium perfect crystals. PMID- 9946957 TI - Spectral theory for two-component porous media. PMID- 9946959 TI - Specific heat of the dissipative two-state system. PMID- 9946958 TI - New method for calculation of quantum-mechanical transmittance applied to disordered wires. PMID- 9946961 TI - Quantum interference effects and the magnitude of the resistivity and thermopower of Ca-Al metallic glasses. PMID- 9946960 TI - Interpretation of diffuse He-atom scattering from steps. PMID- 9946962 TI - Quantum size and surface effects in the electrical resistivity and high-energy electron reflectivity of ultrathin lead films. PMID- 9946964 TI - Resonance Raman scattering and optical absorption studies of MnO4- in KClO4 at high pressure. PMID- 9946963 TI - Comparative high-energy photoelectron diffraction study of Pt(111), Ni(111), and Pt50Ni PMID- 9946965 TI - Vacancy properties in beta -Li-Al. PMID- 9946966 TI - Coexistence of strong 3d antiferromagnetism and mixed-valent Kondo regime transition in Ce(MnxCr PMID- 9946967 TI - Critical behaviors of melting and high-temperature structures in stage-1 rubidium graphite intercalation compounds. PMID- 9946969 TI - Stability and formation of Al-Cu-(Li,Mg) icosahedral phases. PMID- 9946968 TI - Palladium diffusion and cluster nucleation on Ta(110). PMID- 9946971 TI - Exchange-enhanced weak-localization and electron-electron interaction in amorphous paramagnetic Zr-Fe. PMID- 9946970 TI - Far-infrared absorptivity of UPt3. PMID- 9946972 TI - Theoretical study of the electronic structure of ordered and disordered Cu3Au. PMID- 9946973 TI - Cu{001}c(2 x 2)-Pd: An ordered surface alloy. PMID- 9946974 TI - Renormalized polarizability in the Maxwell Garnett theory. PMID- 9946975 TI - Electron-hole pair excitation in multilayered conducting heterostructures. PMID- 9946976 TI - Valence-band and surface electronic structure of CdTe. PMID- 9946977 TI - L2,3 edge of silicon: Theory and experiment. PMID- 9946978 TI - Structure of submonolayer gold on silicon (111) from x-ray standing-wave triangulation. PMID- 9946980 TI - Quantum theory of cyclotron-resonance line shape of a two-dimensional hole gas due to hole-phonon interaction in microstructures. PMID- 9946981 TI - Electronic properties of polyacene. PMID- 9946979 TI - Growth structure of chemisorbed oxygen on GaAs(110) and InP(110) surfaces. PMID- 9946982 TI - Polaritons in semiconductor multilayered materials. PMID- 9946983 TI - Electron-spin resonance in the two-dimensional electron gas of GaAs-AlxGa1-xAs heterostructures. PMID- 9946984 TI - Magnetoconductance in the variable-range-hopping regime due to a quantum interference mechanism. PMID- 9946986 TI - Static nontunneling models for the shallow donors D(H,O) and D(Li,O) in germanium. PMID- 9946985 TI - Optical properties of a neutral Cu-C complex defect in GaP. PMID- 9946987 TI - Photoexcitation and doping studies of poly(3-hexylthienylene). PMID- 9946988 TI - Photoluminescence of two-dimensional excitons in an electric field: Lifetime enhancement and field ionization in GaAs quantum wells. PMID- 9946989 TI - Piezospectroscopy of the ground and excited states of zinc double acceptors in germanium. PMID- 9946991 TI - Effects of external stress on the electronic structure and optical properties of PMID- 9946990 TI - Inelastic electron scattering in amorphous silicon nitride and aluminum oxide with multiple-scattering corrections. PMID- 9946992 TI - Ultrasonic propagation-time measurements in Zn1-xMnxSe down to low temperatures: Shear-wave anomalies and the spin-glass transition. PMID- 9946993 TI - Short-period GaAs-AlAs superlattices: Optical properties and electronic structure. PMID- 9946994 TI - High-order reconstructions of the Ge(100) surface. PMID- 9946995 TI - Soft-x-ray emission and inelastic electron-scattering study of the electronic excitations in amorphous and crystalline silicon dioxide. PMID- 9946996 TI - Optical vibrational modes of ZnSe-ZnSxSe PMID- 9946997 TI - Effective charge and ionicity in Cd1-xMnxTe. PMID- 9946999 TI - Activation of boron-dopant atoms in ion-implanted diamonds. PMID- 9946998 TI - Reformulated Hamiltonian for nonparabolic bands in semiconductor quantum wells. PMID- 9947002 TI - Acoustic phonons in multiconstituent superlattices. PMID- 9947000 TI - Magnetic-field-induced localization in narrow-gap semiconductors Hg1-xCdxTe and InSb. PMID- 9947001 TI - Electron drift mobility in doped amorphous silicon. PMID- 9947003 TI - Subpicosecond time-resolved Raman spectroscopy of LO phonons in GaAs-AlxGa1-xAs multiple-quantum-well structures. PMID- 9947004 TI - Collective excitations of a multiple-quantum-well system with barrier of finite height. PMID- 9947005 TI - Analytic correlation functions for the quantum Hall effect. PMID- 9947006 TI - Interpretation of "optical time-of-flight" measurements in Si. PMID- 9947008 TI - Shear elasticity of KxRb PMID- 9947007 TI - Doping-induced luminescence in polyacetylene. PMID- 9947009 TI - Electrodiffusion of alkali-metal ions and protons in quartz: A diffusion compensation model. PMID- 9947010 TI - Electron-gas theory of some phases of magnesium oxide. PMID- 9947011 TI - Imperfections in amorphous chalcogenides. I. Electrically neutral defects in liquid sulfur and arsenic sulfides. PMID- 9947012 TI - Imperfections in amorphous chalcogenides. II. Detection and structure determination of neutral defects in As-S, Ge-S, and Ge-As-S glasses. PMID- 9947014 TI - Selection of lamellar thickness in polymer crystal growth: A rate-theory model. PMID- 9947013 TI - Imperfections in amorphous chalcogenides. III. Interacting-lone-pair model for localized gap states based on a tight-binding energy-band calculation for As2S PMID- 9947015 TI - Ab initio calculation of the refractive indices and related properties of CaCO3. PMID- 9947016 TI - Hyper-Raman tensors of the zone-center optical phonons in SrTiO3 and KTaO3. PMID- 9947018 TI - Density-functional analysis of Wigner crystallization. PMID- 9947017 TI - Recursion-method study of the electronic states of a two-dimensional square quantum well. PMID- 9947019 TI - Kinetics of the hydrogen chemisorption process for Nb. PMID- 9947020 TI - (hk0) x-ray diffraction of stage-1 SbCl4F-intercalated graphite. PMID- 9947022 TI - Quantum size effects on the optical band gap of microcrystalline Si:H. PMID- 9947021 TI - Theoretical and experimental study of Raman scattering and infrared reflectivity in indium phosphide. PMID- 9947024 TI - Evidence for the onset of Frohlich-mode conductivity in K0.30MoO PMID- 9947023 TI - Thermoelectric power of a one-dimensional electron-gas system. PMID- 9947025 TI - Mass spectroscopy of SbCl5-intercalated graphite. PMID- 9947026 TI - Extended x-ray-absorption fine-structure spectroscopy study of glassy Fe79Si11B10. PMID- 9947027 TI - Pinned mode in polyacetylene: A distribution of soliton-lattice densities. PMID- 9947029 TI - First-principles study of the coverage dependence of the electronic structure of alkali-metal-metal surfaces: Na on Al(001). PMID- 9947028 TI - Novel ultrasonic attenuation peak in alpha '-PdDx. PMID- 9947030 TI - Nonlinear dynamics of localization in a class of one-dimensional quasicrystals. PMID- 9947031 TI - Simple theory of electronic structure: Clusters to crystals. PMID- 9947032 TI - Charge transfer and positron states at alkali-metal-covered nickel surfaces. PMID- 9947034 TI - Photoionization threshold of the deep donor in Si-doped AlxGa1-xAs. PMID- 9947033 TI - Origin and structural sensitivity of surface Auger extended fine structure. PMID- 9947035 TI - Localization and wave-vector conservation for optical phonons in AlxGa1-xAs and thin layers of GaAs. PMID- 9947036 TI - Oxidation of Si(111)-(7 x 7) as studied by scanning tunneling microscopy. PMID- 9947037 TI - Atomic nature of reconstructed Si(110). PMID- 9947038 TI - Picosecond imaging of photoexcited carriers in quantum wells: Anomalous lateral confinement at high densities. PMID- 9947039 TI - Angle-integrated photoemission studies of Ni/Nb(110) and modification of the surface by heat treatment. PMID- 9947040 TI - Multifractal spectral and wave-function properties of the quasiperiodic modulated spring model. PMID- 9947042 TI - Scattering of electrons from atomic surface defects near simple metal surfaces. PMID- 9947041 TI - Optical investigation of quasi-one- and two-dimensional systems A0.9Mo PMID- 9947043 TI - Outer-core emission spectra of heavy alkali metals. PMID- 9947044 TI - Surface lattice dynamics of Cu(111). PMID- 9947045 TI - Photoemission from Ar, Kr, and Xe on Pb(111). PMID- 9947047 TI - Bands and interbands in LaPd3 and CePd3. PMID- 9947046 TI - Magnetic susceptibility of tetrathiafulvalene tetracyanoquinodimethane under pressure. PMID- 9947049 TI - Inequivalence of the physical and Kohn-Sham Fermi surfaces. PMID- 9947048 TI - Temperature dependence of resistance noise in metal-insulator mixtures below the percolation threshold. PMID- 9947050 TI - Electrical conductivity, thermoelectric power, and ESR of a new family of molecular conductors, dicyanoquinonediimine-metal PMID- 9947051 TI - Point-contact spectroscopy in incommensurate chromium. PMID- 9947052 TI - Calculation of phonon dispersion in superlattices using the matching procedure. PMID- 9947053 TI - Bulk and surface phonons in fcc-fcc superlattices using the matching procedure. PMID- 9947055 TI - Bulk band dispersion in Ti2O PMID- 9947054 TI - Topological short-range disorder in Au1-xNix solid solutions: An extended x-ray absorption fine-structure spectroscopy and computer-simulation study. PMID- 9947057 TI - Exact eigenstates on a two-dimensional Penrose lattice and their fractal dimensions. PMID- 9947056 TI - Occupied quasiparticle bandwidth of potassium. PMID- 9947059 TI - Empty-lattice test for non-muffin-tin multiple-scattering equations. PMID- 9947058 TI - Partial densities of states of ordered Cu3Au. PMID- 9947060 TI - EL2 and the electronic structure of the AsGa-Asi pair in GaAs: The role of lattice distortion in the properties of the normal state. PMID- 9947062 TI - Photoconductivity in trans-polyacetylene: Transport and recombination of photogenerated charged excitations. PMID- 9947061 TI - Exciton mixing in quantum wells. PMID- 9947063 TI - Structure and single-phase regime of boron carbides. PMID- 9947065 TI - Time-resolved study of vibrations of a-Ge:H/a-Si:H multilayers. PMID- 9947064 TI - Interface roughness and the dispersion of confined LO phonons in GaAs/AlAs quantum wells. PMID- 9947067 TI - Microscopic structure of the SiO2/Si interface. PMID- 9947066 TI - Dimerization enhancement in one-dimensional Hubbard and Pariser-Parr-Pople models. PMID- 9947068 TI - Resonant Raman-active acoustic phonons in ion-implanted GaAs. PMID- 9947070 TI - Band structure of semiconductor alloys. PMID- 9947069 TI - Diffusion of impurities in amorphous silicon. PMID- 9947071 TI - Comparison of the structural, electrical, and optical properties of amorphous silicon-germanium alloys produced from hydrides and fluorides. PMID- 9947073 TI - Effect of doping percentages on the conductivity and energy gap of a-Si thin films. PMID- 9947072 TI - Experimental surface electronic band structure of the (101-bar0) surfaces of CdS and CdSe. PMID- 9947074 TI - Exciton binding energy in (Al,Ga)As quantum wells: Effects of crystal orientation and envelope-function symmetry. PMID- 9947075 TI - Transfer-matrix algorithm for the calculation of the band structure of semiconductor superlattices. PMID- 9947076 TI - Thermionic emission and Gaussian transport of holes in a GaAs/AlxGa1-xAs multiple quantum-well structure. PMID- 9947077 TI - Optical spectra in conducting polymers: Breaking of symmetries. PMID- 9947078 TI - Heat capacity of the two-dimensional electron gas in GaAs/AlxGa1-xAs multiple quantum-well structures. PMID- 9947079 TI - Electric-field-induced quenching of shallow and deep bound excitons in silicon. PMID- 9947080 TI - Ab initio study of graphite --> diamondlike transitions in BN. PMID- 9947081 TI - Simulations of atomic processes at semiconductor surfaces: General method and chemisorption on GaAs(110). PMID- 9947083 TI - Transient photoconductivity in oriented trans-polyacetylene prepared by the Naarmann-Theophilou method. PMID- 9947082 TI - Gauge-invariant two-photon transitions in quantum wells. PMID- 9947084 TI - Systematic calculations of the band structures of the rare-gas crystals neon, argon, krypton, and xenon. PMID- 9947085 TI - Laser-induced grating spectroscopy of alexandrite crystals. PMID- 9947086 TI - Distribution of tunneling-level barrier heights in (KBr)1-x(KCN)x: Comparison of dielectric response and specific heat. PMID- 9947087 TI - Equilibrium orientations of diatomic-molecular impurities in cubic crystals determined by a polarized Raman study of the stretching mode. PMID- 9947088 TI - Prediction of a high-pressure phase transition and other properties of solid CO2 at low temperatures. PMID- 9947089 TI - Ultrasonic attenuation peaks near the diffuse solid-electrolyte transition temperature in PbF2 and BaF2. PMID- 9947091 TI - Small-angle x-ray scattering study of aqueous solutions of sulfonated calix PMID- 9947090 TI - Second-harmonic generation in quinquethienyl monolayers. PMID- 9947092 TI - Transformation of spatially direct to spatially indirect excitons in coupled double quantum wells. PMID- 9947094 TI - Density matrices for states in the lowest Landau level of a two-dimensional electron gas. PMID- 9947093 TI - Final-state screening in photoemission from adsorbed xenon layers. PMID- 9947095 TI - Bound states trapped by the soliton in the Su-Schrieffer-Heeger model. PMID- 9947096 TI - Broadening of the Landau levels in quasi-two-dimensional conductors caused by impurity scattering. PMID- 9947097 TI - Tetrahedral semiconductors: Constancy of the midgap energies with respect to the vacuum level. PMID- 9947098 TI - EPR observation of a platinum pair complex in Si. PMID- 9947099 TI - Saturation of the density of states of tunneling systems in defective crystalline neutron-irradiated quartz. PMID- 9947100 TI - Comment on volume relaxation around defects in silicon upon electron emission. PMID- 9947101 TI - Reply to "Comment on volume relaxation around defects in silicon upon electron emission" PMID- 9947102 TI - Comment on "Filling three-dimensional space with tetrahedra: A geometric and crystallographic problem" PMID- 9947103 TI - Comment on "Time evolution of Bloch electrons in a homogeneous electric field" PMID- 9947104 TI - Reply to "Comment on 'Time evolution of Bloch electrons in a homogeneous electric field' " PMID- 9947105 TI - Comment on "Exact calculations of quasibound states of an isolated quantum well with uniform electric field: Quantum-well Stark resonance" PMID- 9947106 TI - Defect parameters obtained from positron-annihilation and self-diffusion experiments in silicon. PMID- 9947107 TI - Dependence of core-level photoemission spectra on overlayer growth mode: Al on InP(110). PMID- 9947109 TI - Ordering of isovalent intersemiconductor alloys. PMID- 9947108 TI - X-ray diffraction study of epitaxial Nb-Ta overlayers on sapphire. PMID- 9947110 TI - Carrier-sign reversal in Bi-doped bulk amorphous semiconductors Ge20Te PMID- 9947111 TI - Low-temperature phonon-drag thermoelectric power in heterojunctions. PMID- 9947112 TI - Raman scattering by interface-phonon polaritons in a GaAs/AlAs heterostructure. PMID- 9947114 TI - X-ray-induced secondary-electron emission from solid xenon. PMID- 9947113 TI - Silent soft mode in hexagonal barium titanate observed by hyper-Raman scattering. PMID- 9947115 TI - Anisotropic broadening of the linewidth in the EPR spectra of Cr3+ ions in various doped yttrium aluminum garnet single crystals. PMID- 9947116 TI - Deuterium NMR study of D2O dynamics in glassy and liquid LiCl:D2O. PMID- 9947118 TI - Excitation mechanism of cathodoluminescence of oxisulfides. PMID- 9947117 TI - Quantum diffusion of positive muons in copper. PMID- 9947119 TI - Mossbauer-effect-temperature study of 1,1'-diacetylferrocene in a cold smectic-B liquid crystal. PMID- 9947120 TI - Electronic structure and isomer shifts of Sn halides. PMID- 9947121 TI - Hydrogen trapping by solute atoms in Nb-Mo(3 at. %) alloys as observed by the channeling method. PMID- 9947122 TI - Elastic electron backscattering from surfaces. PMID- 9947123 TI - Ab initio study of electronic properties in free and matrix-isolated iron dihalides. PMID- 9947124 TI - Energy transfer between Er3+ and Tm3+ ions in a barium fluoride-thorium fluoride glass. PMID- 9947126 TI - Theory of the Knight shift in solids: Effect of electron-phonon interaction. PMID- 9947125 TI - Electric field dependence of capture and emission rates by truncated cascade recombination. PMID- 9947127 TI - Models of flux pinning in the quasistatic limit. PMID- 9947128 TI - Energetics and structure of 4He droplets at a finite temperature. PMID- 9947129 TI - X-ray measurements of thermal vacancies in hcp 4He. PMID- 9947130 TI - Intensities of multipole-induced zero-phonon transitions in solid parahydrogen. PMID- 9947131 TI - Destruction by fluctuations of superconducting long-range order in the Abrikosov flux lattice. PMID- 9947132 TI - Exact states and variational states of a periodic two-dimensional cluster of the Heisenberg model. PMID- 9947133 TI - Modulational instability of a boson system. PMID- 9947134 TI - Low-temperature heat-capacity study of the U6X (X=Mn, Fe, Co, Ni) compounds. PMID- 9947135 TI - Nonequilibrium conditions and diffusive transfer of primary excitations in superconducting tunnel-junction detectors. PMID- 9947136 TI - Hydrodynamics of superfluid 4He in a pseudospin model. PMID- 9947137 TI - Spin diffusion in paramagnetic quantum fluids. PMID- 9947138 TI - Theoretical study of lattice instabilities in YBa2Cu3O7. PMID- 9947140 TI - Positron annihilation in the high-Tc superconductors. PMID- 9947139 TI - Possibility of a common origin to ferroelectricity and superconductivity in oxides. PMID- 9947141 TI - Free energy of thallium-based superconductors. PMID- 9947142 TI - Susceptibility, crystal-structure, and specific-heat studies of the high-Tc superconductor and quenched YBa2(Cu0.91Fe0.09) 3Ox. PMID- 9947143 TI - Parallel valence- and core-level photoemission studies of the metal-to-nonmetal transition in YBa2Cu3O7-x. PMID- 9947145 TI - Pairing interaction in CuO clusters. PMID- 9947144 TI - Experimental electronic structure of Bi2CaSr2Cu2O8+ delta. PMID- 9947146 TI - Synthesis and properties of nonstoichiometric samples of YBa2Cu3O7-x; 0.04 <= x <= 1.00. PMID- 9947147 TI - Statistics of holons in the quantum hard-core dimer gas. PMID- 9947148 TI - Plasmons and high-temperature superconductivity. PMID- 9947149 TI - NMR measurement of the exchange coupling between Cu(2) atoms in YBa2Cu3O7- delta (Tc=90 K). PMID- 9947150 TI - Theory of upper critical field, fluctuation conductivity, and fluctuation specific heat for high-Tc superconductors in a magnetic field. PMID- 9947151 TI - Raman scattering from triple perovskites with the Ba2YCu3Ox structure: Normal mode assignments from substitutions on the Ba site. PMID- 9947152 TI - Charge-fluctuation mechanism of high-Tc superconductivity and the isotope effect in oxide superconductors. PMID- 9947154 TI - Diffusion of oxygen in superconducting YBa2Cu3O7- delta ceramic oxides. PMID- 9947153 TI - Anistropic Cu Knight shift and magnetic susceptibility in the normal state of YBa2Cu3O7. PMID- 9947156 TI - Normal modes of tetragonal YBa2Cu3O6 and orthorhombic YBa2Cu3O7. PMID- 9947155 TI - Correlation between superconductivity and normal-state properties in the La1.85Sr0.15 (Cu1-xZnx)O4 system. PMID- 9947157 TI - Metastability in EuBa2(Cu1-xSnx)3O7-y studied by 119Sn and 151Eu Mossbauer spectroscopy. PMID- 9947158 TI - Interfacial effects and superconductivity in high-Tc materials. PMID- 9947159 TI - Raman spectrum of the superconductor Bi2Sr2CaCu2O8. PMID- 9947161 TI - Evidence against a spin-glass transition in three dimensions. PMID- 9947160 TI - Magnetic and structural properties of YBa2Cu3O7-xFy as prepared by a NF3 gas anneal. PMID- 9947162 TI - Exact determination of the Peierls-Nabarro frequency. PMID- 9947163 TI - Finite-size effects in two-dimensional continuum percolation. PMID- 9947164 TI - Ground-state phase diagrams for one-dimensional chains with nonlinear interactions. PMID- 9947166 TI - Variational calculation for the spin-(1/2 Heisenberg antiferromagnet on a square lattice. PMID- 9947165 TI - Gorsky-Bragg-Williams approach to the study of long-period superlattice phases in binary alloys. PMID- 9947167 TI - Magnetic behavior and magnetic phase diagram of the insulating mixed ferromagnet Fe PMID- 9947168 TI - Magnetic transitions in helimagnets. PMID- 9947169 TI - Neutron investigation of incommensurability and metastability in NH4HSeO PMID- 9947170 TI - Lattice parameter and orientation of xenon on graphite at low pressures. PMID- 9947171 TI - Generalized Fibonacci superlattices, dynamical trace maps, and magnetic excitations. PMID- 9947173 TI - Dodecagonal order in a two-dimensional Lennard-Jones system. PMID- 9947172 TI - Finite-size effects at wetting transitions. PMID- 9947174 TI - Polymorphism phase transition and the relative stability of various phases in the LiIO3 crystal. PMID- 9947175 TI - Monte Carlo studies of critical free energies and the simple-cubic Ising model. PMID- 9947176 TI - Magnetism in fcc rhodium and palladium. PMID- 9947177 TI - Self-similarities in one-dimensional periodic and quasiperiodic systems. PMID- 9947178 TI - Phenomenological theory of incommensurate phases in biphenyl. PMID- 9947180 TI - Effects of spin-dependent impurity scattering in itinerant ferromagnets. PMID- 9947179 TI - Universality classes of the theta and theta ' points. PMID- 9947181 TI - Perturbing influence of doubly excited configurations upon the electric-dipole transition amplitudes of rare-earth ions in crystals. PMID- 9947182 TI - Reentrant and successive phase transitions in the Ising model with competing interactions. PMID- 9947183 TI - Magnetic resonance study and computer simulation for the induced unidirectional anisotropy of reentrant Ni-Mn alloys. PMID- 9947185 TI - Approach to the ground state in disordered magnetic systems: Simulated annealing study. PMID- 9947184 TI - Transport properties of a 100-A PMID- 9947186 TI - Squeezed-state approach for phonon coupling in tunneling systems at zero temperature. PMID- 9947187 TI - Q dependence of the magnetic response in URu2Si2. PMID- 9947188 TI - Magnetic properties of the semi-infinite Ising model with a surface amorphization. PMID- 9947189 TI - Mechanism of pressure-induced martensitic phase transformations: A molecular dynamics study. PMID- 9947190 TI - Monte Carlo study of the two-dimensional spin-1/2 quantum Heisenberg model: Spin correlations in La2CuO PMID- 9947192 TI - Dynamical correlations from mobile vortices in two-dimensional easy-plane ferromagnets. PMID- 9947191 TI - Neutron scattering measurements of critical exponents in CsMnBr3: A Z2 >= 1 antiferromagnet. PMID- 9947193 TI - Charge-density oscillations in intermediate-valence and Kondo systems. PMID- 9947194 TI - Magnetotransport of field-induced spin-density waves. PMID- 9947195 TI - Cubic zero-field splitting of a 6S-state ion. PMID- 9947196 TI - Small-angle neutron scattering study of adsorbed water in porous Vycor glass: Supercooling phase transition and interfacial structure. PMID- 9947197 TI - Fracture of disordered, elastic lattices in two dimensions. PMID- 9947198 TI - Percolation in negative field and lattice animals. PMID- 9947200 TI - de Haas-van Alphen effect in the Anderson lattice for large orbital degeneracy. PMID- 9947199 TI - Effects of a zinc-blende-diamond order-disorder transition on the crystal, electronic, and vibrational structures of metastable (GaAs)1-x(Ge2)x alloys. PMID- 9947201 TI - Structural phase transition and high-pressure elastic behavior of III-V semiconductors. PMID- 9947202 TI - Ferroelastic phase transition and phonons in a diatomic-molecular monolayer. PMID- 9947203 TI - q=5 Potts model on the quenched anisotropically site-diluted Penrose lattice. PMID- 9947205 TI - Theoretical determination of the superconducting phase of UPt3. PMID- 9947204 TI - Weyl-Heisenberg group and magnetic translations in finite phase space. PMID- 9947206 TI - Model for the 12.0-mT hydrogen hyperfine doublet in silica. PMID- 9947207 TI - Order parameters in the resonating-valence-bond model. PMID- 9947208 TI - Field-dependent viscosity in partially polarized normal liquid 3He. PMID- 9947209 TI - Tc enhancement in superconductor and spin-density-wave coexistence. PMID- 9947210 TI - Critical current anisotropy in high-Tc superconductors. PMID- 9947211 TI - Ultrasonic velocity anomalies in superconducting sinter-forged YBa2Cu3O7- delta. PMID- 9947212 TI - Significance of the Cu-O chain and a percolation model for superconductivity in YBa2Cu3O7- delta. PMID- 9947213 TI - Hall coefficient of single-crystal Bi2Sr2CaCu2Oy. PMID- 9947214 TI - Electron-energy-loss spectra of the high-Tc superconductors Y-Ba-Cu-O and La-Sr Cu-O. PMID- 9947215 TI - Dynamics of Gaussian interface models. PMID- 9947216 TI - Ordering in the centered-square-lattice Ising model. PMID- 9947218 TI - Nonuniversal Ising-like transition in two-dimensional XY spin systems induced by an external magnetic field. PMID- 9947217 TI - Critical behavior of two-dimensional magnetic systems with dipole-dipole interactions. PMID- 9947219 TI - Comment on "Magnetism in Au82.5Fe17.5" PMID- 9947220 TI - Reply to "Comment on 'Magnetism in Au82.5Fe17.5" PMID- 9947221 TI - Erratum: Fourier-transform method for accurate analysis of Mossbauer spectra PMID- 9947222 TI - Erratum: Cooperative weak links in sintered Y-Ba-Cu-O superconductor PMID- 9947224 TI - Integer charge transport in Josephson junctions. PMID- 9947223 TI - Erratum: Nature of the valence photoemission features of single-crystal YBa2Cu3O7 x PMID- 9947225 TI - Low-coverage alkali-metal-induced surface structural changes in III-V semiconductors: Photoemission extended x-ray absorption fine-structure study of the Na/InP(110) interface. PMID- 9947226 TI - Directional correlation between the primary particle and ejected molecular ions in electronic sputtering of large organic molecules. PMID- 9947228 TI - Near-neighbor defect contribution to the hyperfine field of Fe in Fe. PMID- 9947227 TI - New form of scanning optical microscopy. PMID- 9947229 TI - Temperature dependence of the Raman spectra for Bi2CaSr2Cu2O8. PMID- 9947230 TI - Chain-site versus plane-site Cu substitution in YBa2Cu3-xMxO7 (M=Co,Ni): Hall and thermopower studies. PMID- 9947231 TI - 17O NMR spectroscopy of magnetically ordered YBa2Cu3O7-x microcrystals. PMID- 9947232 TI - Power-law temperature dependence of the electrodynamic properties in oriented YBa2Cu3O7- delta and Y2Ba4Cu8O16- delta films. PMID- 9947233 TI - Specific heat of model high-temperature superconductors: Effects of magnetic fields. PMID- 9947234 TI - Character of doped oxygen holes in high-Tc Cu oxides. PMID- 9947235 TI - Low-field dependence of the microwave absorption in superconducting YBa2Cu3O7-x near Tc. PMID- 9947236 TI - Electron tunneling and the energy gap in Bi2Sr2CaCu2Ox. PMID- 9947237 TI - Thermal properties of single-crystal La2CuO4- Delta. PMID- 9947238 TI - Structure in the magnetic-field-dependent microwave absorption of Bi-Sr-Ca-Cu-O single crystals. PMID- 9947240 TI - Frequency-dependent conductivity from carriers in Mott insulators. PMID- 9947239 TI - Charge-density waves and superconductivity in the Ba1-xKxBiO3-y system. PMID- 9947241 TI - Possible role of the alkaline-earth ions in high-temperature superconductivity. PMID- 9947243 TI - Sound velocity and attenuation in single-crystal YBa2Cu3O7- delta. PMID- 9947242 TI - Nature of the states near the Fermi level of the layered superconductors of Bi2Ca1Sr2Cu2O8 and Bi2Sr2CuO6. PMID- 9947244 TI - Absence of metallic character at certain Cu sites in YBa2Cu PMID- 9947245 TI - Antiferromagnetism of CuO2 layers. PMID- 9947246 TI - Attractive and repulsive pairing interaction vertices for the two-dimensional Hubbard model. PMID- 9947247 TI - Ultrasonic attenuation measurements in sinter-forged YBa2Cu3O7- delta. PMID- 9947248 TI - Static magnetic order in Bi2Sr2YCu2Ox and spin freezing in Bi2SrYCaCu2Ox detected by muon-spin rotation. PMID- 9947250 TI - Instability of the long-range resonating-valence-bond state in the mean-field approach. PMID- 9947249 TI - Magnetic penetration depth in single-crystal YBa2Cu3O7- delta. PMID- 9947251 TI - Paramagnetic susceptibility of YBa2Cu3O7- delta at high temperatures. PMID- 9947252 TI - 130-K superconductivity and microwave absorption in Tl-Ba-Ca-Cu-O. PMID- 9947253 TI - Tight-binding approach to the orbital magnetic moment and magnetocrystalline anisotropy of transition-metal monolayers. PMID- 9947254 TI - Variational calculations for the Sutherland model. PMID- 9947255 TI - Magnetic correlations in random-anisotropy-axis models. PMID- 9947256 TI - Random resistor network with an exponentially wide distribution of bond conductances. PMID- 9947257 TI - Percolationlike exponent for the conductivity of highly disordered resistor networks. PMID- 9947258 TI - Phase boundary and magnetization in field-induced spin-density-wave systems. PMID- 9947259 TI - Self-ordering in diffusion-controlled reactions: Exciton fusion experiments and simulations on naphthalene powder, percolation clusters, and impregnated porous silica. PMID- 9947260 TI - Nonuniversality of transport exponents in continuum percolation systems: Effects of finite jump distance. PMID- 9947261 TI - Evidence for a temperature-induced order-disorder phase transition on W(100). PMID- 9947262 TI - Effect of the morphology of patterns on the scaling functions: Off-critical quenches. PMID- 9947263 TI - Polarized experimental and theoretical K-edge x-ray absorption studies of SO42-, ClO3-, S2O PMID- 9947264 TI - Secondary electron emission from thin foils under fast-ion bombardment. PMID- 9947265 TI - Isomer shift of 133Cs implanted in various elements. PMID- 9947266 TI - Nuclear spin-lattice relaxation times for mixtures of ortho- and para-H2. II. Low ortho-H2 concentration. PMID- 9947268 TI - Optically detected multipulse nuclear-quadrupole-resonance studies of trivalent praseodymium in zero and weak static magnetic fields. PMID- 9947267 TI - Ab initio calculations of NMR satellite data for 3d impurities in Cu. PMID- 9947269 TI - Resonant enhancement of direct two-photon absorption in Tb3+:LiYF4. PMID- 9947271 TI - Locally resolved isotropic and anisotropic 13C Knight shifts in the organic conductor (fluoranthenyl)2X (X=AsF6, PF6). PMID- 9947270 TI - Coil detection of optically generated magnons in MnF2:Er3+ PMID- 9947272 TI - Multiple small-angle scattering from a polydispersed random medium. PMID- 9947273 TI - Quantum effect of magnetic flux on the energy levels of rigid XH3 rotators. PMID- 9947274 TI - Molecular-dynamical calculations of irradiation-produced point defects in bcc metals. PMID- 9947275 TI - Optical study and analysis of Pu4+ in single crystals of ZrSiO4. PMID- 9947276 TI - Short-range order in Au-Fe alloys studied by high-temperature Mossbauer spectroscopy. PMID- 9947277 TI - Paramagnetic hyperfine interactions of iron in solid ammonia from Mossbauer spectroscopy. PMID- 9947278 TI - Crystal-field splitting and magnetic relaxation in CeCu20.2Si2. PMID- 9947279 TI - High-field specific heat of CeCu2Si2 and CeAl3. PMID- 9947280 TI - Cooper-pair mass. PMID- 9947282 TI - Quantum vortex dynamics in granular superconducting films. PMID- 9947281 TI - Superconductivity and spin-density waves. PMID- 9947283 TI - Suppression of the transition temperature in a one-dimensional superconductor. PMID- 9947284 TI - Upper critical field of organic superconductors. PMID- 9947285 TI - Charging effects and quantum properties of small superconducting tunnel junctions. PMID- 9947286 TI - Critical current of an inhomogeneous superconductor as a percolation-breakdown phenomenon. PMID- 9947287 TI - Perturbative analysis of long Josephson junctions having uniform bias and spatially varying penetration depth. PMID- 9947288 TI - Superconducting Tc enhancement due to negative-U impurities: Monte Carlo study of a local exciton model. PMID- 9947290 TI - Finite-size scaling and the convective conductance and specific heat of planar helium films near the superfluid transition. PMID- 9947289 TI - Intensities of zero-phonon Uv(0) and Qv(0)+Uv'(0) transitions in solid H2, D2, and HD. PMID- 9947291 TI - Healing length near the lambda point in liquid helium. PMID- 9947292 TI - Sounds in one-dimensional superfluid helium. PMID- 9947293 TI - Neutral fermions in effective-gauge-field theories of doped Mott insulators. PMID- 9947294 TI - Modifications of the physical properties of the high-Tc superconductors YBa2Cu3O7 delta (0.1 <= delta <0.7) by 3.5-GeV xenon ion bombardment. PMID- 9947295 TI - Temperature dependence of the local structure of YBa2Cu3O7- delta with varying oxygen content: An x-ray-absorption study. PMID- 9947296 TI - Transport in crystalline La2CuO4+ delta : Enormous anomalies at TN for small hole doping. PMID- 9947297 TI - Reflectivity and conductivity of YBa2Cu3O7. PMID- 9947298 TI - Formation of a large singlet bipolaron: Application to high-temperature bipolaronic superconductivity. PMID- 9947299 TI - Magnetic susceptibility of YBa2Cu3O6+x: Effects of spin frustration and correlation. PMID- 9947301 TI - Temperature-, magnetic-field-, and power-dependent microwave resistance of YBa2Cu3O7- delta. PMID- 9947302 TI - Oxygen concentration effect on Tc of the Bi-Ca-Sr-Cu-O superconductor. PMID- 9947300 TI - Interacting hole-spin model for oxide superconductors. PMID- 9947303 TI - Flux creep and activation energies at the grain boundaries of Y-Ba-Cu-O superconductors. PMID- 9947304 TI - Symmetry of holes in high-Tc superconductors. PMID- 9947305 TI - Photon-stimulated desorption and total-electron yield from DyBa2Cu3O7-x between 15-180 eV. PMID- 9947306 TI - Band structure of Bi2Sr2CaCu2O8 studied by angle-resolved photoemission. PMID- 9947307 TI - Superconductivity and electronic structure of Bi-based compounds. PMID- 9947308 TI - Superconductivity, intergrain, and intragrain critical current densities of materials. PMID- 9947309 TI - Magnetic properties of Gd2CuO4 crystals. PMID- 9947310 TI - Microstructure, lattice parameters, and superconductivity of YBa2(Cu1-xFex)3O7- delta for 0 <= x <= 0.33. PMID- 9947311 TI - Variation of electronic and atomic structures in YBa2(Cu1-xFex)3O7- delta. PMID- 9947312 TI - Oxygen isotope effect in YBa2Cu3O7 prepared by burning YBa2Cu3 in 16O and 18O. PMID- 9947313 TI - ESR experiments and spectra simulations in YBa2Cu3O7-x, Y2BaCuO5, and BaCuO2+x. PMID- 9947314 TI - Electronically driven instabilities of La2-xMxCuO4. PMID- 9947316 TI - Temperature dependence of far-infrared difference reflectivity of YBa2Cu PMID- 9947315 TI - Linear charge-density-wave instability in YBa2Cu3O7- delta and the pair-breaking effect from Coulomb scattering with superconducting electrons. PMID- 9947318 TI - Langevin and Fokker-Planck equation with nonconventional boundary conditions for the description of domain-wall dynamics in ferromagnetic systems. PMID- 9947317 TI - Oxygen-vacancy phase equilibria in YBa2Cu3Oz calculated by the cluster variation method. PMID- 9947319 TI - Field theory of the two-dimensional Ising model: Conformal invariance, order and disorder, and bosonization. PMID- 9947321 TI - 14N nuclear-quadrupole-resonance study of solitons and charge-density waves during the Peierls transition in potassium tetracyanoquinodimethane. PMID- 9947320 TI - Dynamics of diluted antiferromagnetic Ising spin systems on the fcc lattice. PMID- 9947323 TI - Monte Carlo calculation of the size distribution of supported clusters. PMID- 9947322 TI - Density-functional theory of crystal-melt interfaces. PMID- 9947324 TI - Nonlinear sigma models for triangular quantum antiferromagnets. PMID- 9947325 TI - Thue-Morse quantum Ising model. PMID- 9947326 TI - Measurement of the fourth moment of the current distribution in two-dimensional random resistor networks. PMID- 9947327 TI - Order-disorder critical behavior of orientationally ordered incommensurate overlayers of cesium and potassium on the Cu(111) surface. PMID- 9947328 TI - Infinite set of crossover exponents of the XY model and f( alpha ) approach. PMID- 9947329 TI - Surface retarded modes in multilayered structures: Parallel magnetization. PMID- 9947331 TI - Anisotropic Kondo effect in a valence-fluctuating system: CeNiIn. PMID- 9947330 TI - Bulk and surface retarded modes in multilayered structures: Antiparallel magnetization. PMID- 9947332 TI - Electron-phonon interaction mechanism of magnetovolume and magnetoelasticity effects in itinerant electron ferromagnets. PMID- 9947333 TI - Harmonic magnons in Cd1-xMnxTe and Zn1-xMnxTe. PMID- 9947334 TI - W{100} clean surface phase transition studied by core-level-shift spectroscopy: Order-order or order-disorder transition. PMID- 9947336 TI - Equilibrium polymerization on the equivalent-neighbor lattice. PMID- 9947335 TI - Motion of a single hole in a quantum antiferromagnet. PMID- 9947337 TI - Time evolution of the nonadiabatic nonlinear quantum dimer. PMID- 9947338 TI - Magnetism and local order: Ab initio tight-binding theory. PMID- 9947339 TI - Metastable states of Ising spin glasses and random ferromagnets. PMID- 9947340 TI - Critical scattering of electrons in CeSb1-xTex. PMID- 9947341 TI - Excited-state absorption by Eu2+ in KBr, KCl, and NaCl. PMID- 9947342 TI - Thickness and polarization dependence of the magnetooptic signal from ultrathin ferromagnetic films. PMID- 9947343 TI - Magnetovolume instabilities and ferromagnetism versus antiferromagnetism in bulk fcc iron and manganese. PMID- 9947344 TI - Band magnetism in the Hubbard model. PMID- 9947346 TI - Fluctuations in transmission of waves through disordered slabs. PMID- 9947345 TI - Electron-spin-resonance study of two-dimensional antiferromagnet stage-2 MnCl2 graphite intercalation compound. PMID- 9947347 TI - Conductance and exchange coupling of two ferromagnets separated by a tunneling barrier. PMID- 9947348 TI - Critical behavior in quantum spin chains with composite spin. PMID- 9947349 TI - Detection of spin-flip ESR transitions and Arrhenius behavior for the AsO4 4- center in the KH2AsO4-type ferroelectric compounds at high temperatures. PMID- 9947350 TI - Sublattice-ordered phases of Griffiths's three-component model. PMID- 9947351 TI - Global phase diagram for binary alloys with one magnetic component. PMID- 9947352 TI - Sublattice-ordered phases in a lattice model for a micellar solution. PMID- 9947354 TI - Correspondence between quasiperiodic Schrodinger equations and tight-binding Hamiltonians. PMID- 9947353 TI - Diffusion and localization in hierarchical potentials. PMID- 9947356 TI - Exact-diagonalization study of the effective model for holes in the planar antiferromagnet. PMID- 9947355 TI - Soliton dynamics and fluctuations in sine-Gordon-like magnetic chains. PMID- 9947357 TI - Magnetic phase diagram and anisotropy of pseudoternary (ErxDy1-x)2Fe14B compounds. PMID- 9947359 TI - Information dimension in fractal structures. PMID- 9947358 TI - Monte Carlo studies of anisotropic surface tension and interfacial roughening in the three-dimensional Ising model. PMID- 9947360 TI - Kohn-Sham density-functional approach to dense magnetic polarons in magnetic semiconductors. PMID- 9947361 TI - Orientational phase transitions in systems of adsorbed molecules. PMID- 9947362 TI - Effect of correlations on the localization properties of electrons and phonons in the long-wavelength limit. PMID- 9947363 TI - Potts model in a random field. PMID- 9947364 TI - Sequences of second-order, first-order, and reentrant phase transitions in anisotropic systems with cubic symmetry. PMID- 9947365 TI - Solitons in one-dimensional antiferromagnetic chains. PMID- 9947366 TI - Fluctuation effects in the herringbone orientational phase transition. PMID- 9947367 TI - Proton conductivity in quasi-one-dimensional hydrogen-bonded systems: Nonlinear approach. PMID- 9947368 TI - Finite-temperature real-time field theories for spin (1/2. PMID- 9947369 TI - Relevance of the imaginary-time branch in real-time formalisms for thermodynamic equilibrium: Study of the Heisenberg model. PMID- 9947370 TI - Collisions of solitary-wave-like objects in a damped driven ferromagnetic system: The Bloch wall. PMID- 9947371 TI - Numerical investigation of the role of topological defects in the three dimensional Heisenberg transition. PMID- 9947373 TI - Fluctuations in granular superconductors. PMID- 9947372 TI - Effective Lagrangian for holes in the spin-liquid state. PMID- 9947374 TI - Nuclear-spin-lattice relaxation in rhenium metal. PMID- 9947375 TI - Measurement of cross-relaxation times in Tm2+:SrF2 by optical means. PMID- 9947376 TI - Perturbation treatment of the reverse ac Josephson effect. PMID- 9947378 TI - Nature of the magnetic order of Gd in superconducting and nonsuperconducting GdBa2Cu3O7- delta. PMID- 9947377 TI - Superconductivity in the system Bi2Sr2-xLaxCuO6+ delta : Hole formation by (LaO)+ PMID- 9947379 TI - Percolation models in granular high-Tc superconductors in the transition region. PMID- 9947380 TI - Infrared reflectivity and vibrational structure of superconducting Bi2Sr2CaCu2O8+x. PMID- 9947381 TI - Enhanced pairing in the repulsive Hubbard model with next-nearest-neighbor hopping. PMID- 9947382 TI - Electric birefringence of a binary liquid mixture near the critical consolute point. PMID- 9947383 TI - Domain growth and scaling in the two-dimensional Langevin model. PMID- 9947384 TI - Exact ground state of a class of quantum spin systems. PMID- 9947385 TI - Effect of exchange interaction on spin reorientation in the Nd2Fe14B system. PMID- 9947386 TI - Influence of external dc electric bias on the nonlinear pyroelectric current. PMID- 9947387 TI - Application of real-space renormalization techniques to one-dimensional models. PMID- 9947388 TI - Electronic damping of spin waves in disordered itinerant ferromagnets. PMID- 9947389 TI - Isobaric electrical resistance along the critical line in nickel: An experimental test of universality. PMID- 9947390 TI - Scaling of the negative moments of the harmonic measure in diffusion-limited aggregates. PMID- 9947391 TI - Ultrasonic attenuation and fractal surfaces in porous media. PMID- 9947392 TI - Reply to comment "Ultrasonic attenuation and fractal surfaces in porous media" PMID- 9947393 TI - Erratum: Coexistence of antiferromagnetism and superconductivity in a mean-field theory of high-Tc superconductors PMID- 9947394 TI - Ferromagnetic spin interactions between benzene anions: Molecular-orbital analysis and the Hubbard model. PMID- 9947395 TI - Magnetic pairing in a lattice of Kondo ions: Application to UPt3. PMID- 9947396 TI - Flux creep and critcal-current anisotropy in Bi2Sr2CaCu2O8+ delta. PMID- 9947397 TI - Possibility of a resonating-valence-bond state in the high-Tc superconductor Bi4Ca3Sr3Cu4O16+x. PMID- 9947398 TI - Surface study of the 83-K superconductor Bi2Sr2CaCu2O8 by low-energy electron diffraction and angle-resolved inverse photoemission spectroscopy. PMID- 9947400 TI - Hall-effect anomaly in the high-Tc copper-based perovskites. PMID- 9947399 TI - Approaching the Mott-Hubbard insulator in the 85-K superconductor Bi2(Sr,Ca)3Cu2O8+d by doping with Tm. PMID- 9947401 TI - Empty states near the Fermi level in Bi2Sr2CaCu2O8. PMID- 9947402 TI - NMR evidence for localized spins on Cu(2) sites from Cu NMR in YBa2Cu3O7 and YBa2Cu3O6.75 single crystals. PMID- 9947404 TI - Flux creep in a polycrystalline Ba0.6K0.4BiO3 superconductor. PMID- 9947403 TI - Soft phonon mode in the high-Tc superconductor Tl-Ba-Ca-Cu-O. PMID- 9947405 TI - Photoemission and inverse resonant photoemission studies of Tl2Ba2Ca2Cu3O10+y. PMID- 9947407 TI - Phonon echoes in powders of high-Tc superconducting YBa2Cu3O7- delta. PMID- 9947406 TI - Eight new high-temperature superconductors with the 1:2:4 structure. PMID- 9947408 TI - Inverse photoemission study of Bi2Sr2CaCu2O8. PMID- 9947409 TI - Direct evidence for the quantum interlayer defect-assisted percolation model of cuprate high-Tc superconductivity. PMID- 9947410 TI - Resonant-photoemission study of Ba0.6K0.4BiO3. PMID- 9947411 TI - Theory for oxygen content and ordering in YBa2Cu3O6+x in equilibrium with oxygen gas. PMID- 9947412 TI - Origin of resonating-valence-bond states for a Hubbard-type model. PMID- 9947413 TI - Spin susceptibility in superconducting YBa2Cu3O7 from 63Cu Knight shift. PMID- 9947414 TI - Exact mapping from a two-band model for Cu oxides to the single-band Hubbard model. PMID- 9947416 TI - Spin-fluctuation resonance in mixed-valence materials. PMID- 9947415 TI - Low-temperature structure of Ba0.6K0.4BiO3. PMID- 9947417 TI - Neutron-spectroscopy measurement of a fracton density of states. PMID- 9947419 TI - Time-dependent local perturbation in a free-electron gas: Exact results. PMID- 9947418 TI - Multiple-scattering approach to oxygen K near-edge structures in electron-energy loss spectroscopy of alkaline earths. PMID- 9947421 TI - Exciton-polariton dynamics and photoluminescence line shapes in cadmium telluride. PMID- 9947420 TI - Electron localization and interaction effects in Au/Si multilayered systems. PMID- 9947423 TI - Effect of magnetic field on the heat capacity of Ni3Al alloys. PMID- 9947422 TI - Model of metallic cohesion: The embedded-atom method. PMID- 9947424 TI - Electronic structure of a NbC0.9(100) surface: Angle-resolved photoemission study. PMID- 9947426 TI - Atomistic simulation of defect-induced amorphization of binary lattices. PMID- 9947425 TI - Electron transmission across an interface of different one-dimensional crystals. PMID- 9947427 TI - Angle-resolved photoemission and inverse photoemission from Ag(100). PMID- 9947428 TI - Hole mobilities in hydrazone-polycarbonate dispersions. PMID- 9947429 TI - Electronic theory for solid-solution hardening and softening of dilute Al-based alloys: Elastic-moduli enhancement of Al-Li alloys. PMID- 9947430 TI - Dynamics of adsorbate core-hole decay. II. Lifetimes. PMID- 9947431 TI - Impurity effects on metallic cohesion: Lithium-row atoms in nickel clusters. PMID- 9947432 TI - Dynamics of the charge-density-wave mode in (NbSe4)2I. PMID- 9947433 TI - Exact solution of a quantum electron-phonon system for a two-site periodic cluster. PMID- 9947434 TI - Resonance electron scattering from adsorbed molecules: Angular distribution of inelastically scattered electrons and application to physisorbed O2 on graphite. PMID- 9947435 TI - Weak localization and enhanced electron-electron interaction in amorphous Ca70(Mg,Al)30. PMID- 9947437 TI - Hopping transport of localized pi electrons in amorphous carbon films. PMID- 9947436 TI - Surface-plasmon coupling in cylindrical pores. PMID- 9947438 TI - Raman scattering study of SbSBr at high pressure. PMID- 9947439 TI - X-ray Raman scattering as a substitute for soft-x-ray extended x-ray-absorption fine structure. PMID- 9947440 TI - Ordering kinetics of a chemisorbed overlayer: O/W(110). PMID- 9947441 TI - Hydrogen hopping rates and hydrogen-hydrogen interactions in PdHx. PMID- 9947442 TI - Coulomb interaction and optical absorption in polydiacetylene chains. PMID- 9947443 TI - Effect of impurities on the charge-density-wave dynamics in Ta1-xNbx PMID- 9947444 TI - Line asymmetry in the x-ray photoelectron spectra of Ar and K implanted in Al. PMID- 9947445 TI - Electrical conductivity of ZnS crystals: ZnS crystals as quasi-one-dimensional conductors. PMID- 9947446 TI - Coupled plasmon and phonon excitations in the space-charge layer on GaAs(110) surfaces. PMID- 9947447 TI - Dynamical screening in the cooling theory of high-density electron-hole plasmas. PMID- 9947449 TI - Classical-trajectory calculations on Ar+ sputtering of a Si(001) surface using an ab initio potential. PMID- 9947448 TI - Screening of positrons in semiconductors and insulators. PMID- 9947450 TI - Two-dimensional excitons in magnetic fields. PMID- 9947451 TI - Calculated optical and structural properties of InP under pressure. PMID- 9947452 TI - Perimeter magnetoplasmons in tunneling-ring semiconductor superlattices. PMID- 9947453 TI - Self-consistent study of the resonant-tunneling diode. PMID- 9947454 TI - Optical investigation of the exciton transfer between growth islands of different well widths in GaAs/AlxGa1-xAs quantum wells. PMID- 9947455 TI - Geometric and electronic structure of antimony on the GaAs(110) surface studied by scanning tunneling microscopy. PMID- 9947456 TI - Electronic structure of TiSi2. PMID- 9947457 TI - Optical properties of quinolinium ditetracyanoquinodimethanide PMID- 9947459 TI - Gauge-invariant tight-binding approach to magnetotunneling in superlattices. PMID- 9947458 TI - Electronic structure of the Si/GaP(110) interface. PMID- 9947460 TI - Photoluminescence of disorder-induced localized states in GaAs/AlxGa1-xAs superlattices. PMID- 9947461 TI - Electronic structure and deep impurity levels in structure-modulated zinc-blende wurtzite semiconductor superlattices. PMID- 9947462 TI - Interface electronic structures in an InAs/GaAs lattice-mismatched system. PMID- 9947463 TI - Model calculations of the quantum ballistic transport in two-dimensional constriction-type microstructures. PMID- 9947464 TI - Hot-electron magnetophonon resonance in a two-dimensional electron gas. PMID- 9947465 TI - Renormalization group and dynamical maps for the hierarchical tight-binding problem. PMID- 9947466 TI - Ab initio calculation of pressure coefficients of band gaps of silicon: Comparison of the local-density approximation and quasiparticle results. PMID- 9947467 TI - Growth mechanism and clustering phenomena: The Ge-on-Si system. PMID- 9947468 TI - Monte Carlo studies of nonequilibrium phonon effects in polar semiconductors and quantum wells. I. Laser photoexcitation. PMID- 9947470 TI - Vibrational excitations in a-Si1-xCx:H alloys. PMID- 9947469 TI - Monte Carlo studies of nonequilibrium phonon effects in polar semiconductors and quantum wells. II. Non-Ohmic transport in n-type gallium arsenide. PMID- 9947471 TI - Dependence on uniaxial stress of deep levels in III-V compound and group-IV elemental semiconductors. PMID- 9947472 TI - X-ray-absorption spectroscopy of ZnTe, CdTe, and HgTe: Experimental and theoretical study of near-edge structures. PMID- 9947474 TI - Effects of temperature on dislocation properties in Xe monolayers. PMID- 9947473 TI - Auger effect in the Mn2+ luminescence of CdF2:(Mn,Y) crystals. PMID- 9947476 TI - Hi0(Li) and Di0(Li) defects in CaO studied by EPR: Reorientational and vibrational features. PMID- 9947475 TI - Thermal transport near the glass transition in bulk As-Se glasses. PMID- 9947477 TI - Surface vibrations, soft modes, and structural phase transitions of (001) slabs of KMnF3 and KZnF3. PMID- 9947478 TI - Electronic structure of lithium beryllium hydride. PMID- 9947479 TI - Ab initio study of the x-ray edge in alkali metals and alloys. PMID- 9947480 TI - Observation of the effect of refraction on x rays diffracted in a grazing incidence asymmetric Bragg geometry. PMID- 9947481 TI - Photoacoustic measurement of the thermal diffusivity of Pb1-xSnxTe alloys. PMID- 9947482 TI - Fractional quantum Hall effect in tilted magnetic fields. PMID- 9947483 TI - Local empirical pseudopotential approach to the optical properties of Si/Ge superlattices. PMID- 9947484 TI - Structures of the heat-treatment centers NL8 and NL10 in silicon. PMID- 9947486 TI - dc conductivity and gap energies in the fractional quantum Hall effect. PMID- 9947485 TI - Intraband absorption of infrared radiation in a semiconductor quantum dot. PMID- 9947487 TI - Determination of atom positions at stacking-fault dislocations on Au(111) by scanning tunneling microscopy. PMID- 9947488 TI - Many-body optical-edge singularity in absorption spectra of GaAs/AlxGa1-xAs modulation-doped quantum wells. PMID- 9947489 TI - Temperature-induced structural phase transition in CaBr2 studied by Raman spectroscopy. PMID- 9947490 TI - Investigation with low-energy electron diffraction of the adsorbate-induced metal relaxations in the Cu(100)-(2 x 2)-S surface structure. PMID- 9947492 TI - Comment on "Binding and formation energies of native defect pairs in GaAs" PMID- 9947491 TI - Reply to "Investigation with low-energy electron diffraction of the adsorbate induced metal relaxations in the Cu(100)-(2 x 2)-S surface structure" PMID- 9947493 TI - Reply to "Comment on 'Binding and formation energies of native defect pairs in GaAs' " PMID- 9947494 TI - Erratum: Band structure of a semimagnetic semiconducting alloy: A photoemission study of Cd1-xMnxTe PMID- 9947495 TI - Influence of Au overlayers on valence-band offsets for buried CaF2/Si(111) interfaces. PMID- 9947497 TI - Co/Si(111) interface investigated by bremsstrahlung isochromat spectroscopy and x ray-induced photoemission spectroscopy. PMID- 9947496 TI - Surface-plasmon-induced desorption by the attenuated-total-reflection method. PMID- 9947498 TI - dc and ac soliton conductivity of disordered charge-density-wave systems and long Josephson junctions. PMID- 9947500 TI - Breakdown of the linear approximation to the Boltzmann transport equation in quasi-one-dimensional semiconductors. PMID- 9947499 TI - Asymptotic biexciton "binding energy" in quantum dots. PMID- 9947501 TI - Infrared photoelectron tunneling spectroscopy of strongly coupled quantum wells. PMID- 9947502 TI - Optical investigations of the high-density electron gas in pseudomorphic InxGa1 xAs quantum-well structures. PMID- 9947503 TI - Microstructure and Schottky-barrier height of the Yb/GaAs interface. PMID- 9947504 TI - Nonlinear conductance of quantum point contacts. PMID- 9947505 TI - Comparison of models for the even-denominator fractional quantum Hall effect. PMID- 9947506 TI - Direct evidence of the occupied valence states for adsorbed Cs atoms on the Si(111) surface. PMID- 9947507 TI - Structure and dynamics of the Be-H complex in GaAs. PMID- 9947508 TI - Excess elastic energy and the instability of bulk and epitaxial lattice mismatched monolayer (001) superlattices. PMID- 9947509 TI - Negative magnetoresistance in the variable-range-hopping regime in n-type GaAs. PMID- 9947510 TI - Dynamical conductivity of a quasi-one-dimensional electron gas. PMID- 9947512 TI - X-ray photoelectron spectroscopy studies of the chemical structure of polyaniline. PMID- 9947513 TI - Electronic properties of stable icosahedral alloys. PMID- 9947511 TI - Suppression of Shubnikov-de Haas resistance oscillations due to selective population or detection of Landau levels: Absence of inter-Landau-level scattering on macroscopic length scales. PMID- 9947514 TI - Calculated ground-state and optical properties of potassium under pressure. PMID- 9947515 TI - Electronic structure of the Ag/Si interface: Angle-resolved, energy-dependent, photoemission study. PMID- 9947517 TI - Damping and undamping in a simple model of quantum self-trapping. PMID- 9947516 TI - Pseudospherical integration scheme for electronic-structure calculations. PMID- 9947519 TI - Monte Carlo simulation study of a microscopic model for H diffusion in amorphous Pd1-ySiyHx alloys. PMID- 9947518 TI - Quasicrystallinity in the Ti2Ni(Si) system. PMID- 9947520 TI - Theoretical evaluation of structure factors and computation of coordination number, compressibility, and self- and mutual-diffusion coefficients of the Hg-Tl alloy. PMID- 9947522 TI - Low-temperature ultrasonic relaxation and resonance in RbCl:OH. PMID- 9947521 TI - Surface-plasmon dispersion relation for the inhomogeneous charge-density medium. PMID- 9947523 TI - Empty-electronic-state evolution for Sc and electron dynamics at the 3p-3d giant dipole resonance. PMID- 9947524 TI - Nonlocal resistance and magnetoresistance in bulk metals. PMID- 9947525 TI - Near-surface Ag distribution in intercalated Ag-TiS2. PMID- 9947526 TI - Structural dependence of the 5d-metal surface energies as deduced from surface core-level shift measurements. PMID- 9947527 TI - Applications of the quadratic Korringa-Kohn-Rostoker band-theory method. PMID- 9947529 TI - Quasiparticle excitation spectrum for nearly-free-electron metals. PMID- 9947528 TI - Connection between blazes from gratings and enhancements from random rough surfaces. PMID- 9947530 TI - Kramers-Kronig analysis of reflection electron-energy-loss spectra measured with a cylindrical mirror analyzer. PMID- 9947532 TI - 67Zn Mossbauer study of zinc metal at high pressure. PMID- 9947531 TI - Work function, optical absorption, and second-harmonic generation from alkali metal atoms adsorbed on metal surfaces. PMID- 9947533 TI - Relationship between Auger and autoionization processes. PMID- 9947535 TI - Photoconductivity measurements of x-ray-absorption spectra of tetramethyl tin in 2,2,4-trimethylpentane near the Sn K edge. PMID- 9947534 TI - Surface collective oscillations of metal clusters and spheres: Random-phase approximation sum-rules approach. PMID- 9947537 TI - Electron scattering by atomic chains: Multiple-scattering effects. PMID- 9947536 TI - Electronic structure of metallic and semiconducting alkali-metal-lead compounds. PMID- 9947538 TI - Interaction of light with an atom near the surface of a superlattice. I. Periodic case. PMID- 9947539 TI - Interaction of light with an atom near the surface of a superlattice. II. Quasiperiodic case. PMID- 9947540 TI - Influence of Coulomb correlation on Landau states in CdTe. PMID- 9947541 TI - Triply resonant second-order Raman scattering at the E0 and E0+ Delta 0 gap of GaP under uniaxial stress. PMID- 9947542 TI - Effects of thermal diffuse scattering and surface tilt on diffraction and channeling of fast electrons in CdTe. PMID- 9947543 TI - Time-dependent tunneling of electron wave packets in a transverse magnetic field. PMID- 9947544 TI - Interference photoconductivity and photoelectromagnetic effect in amorphous silicon. PMID- 9947545 TI - Possible coexistence of localized and extended states in the quantum Hall effect. PMID- 9947547 TI - Properties of the electron-hole plasma in GaAs-(Ga,Al)As quantum wells: The influence of the finite well width. PMID- 9947548 TI - Short-range order in amorphous germanium-nitrogen alloys studied by extended x ray-absorption fine-structure spectroscopy. PMID- 9947546 TI - Feynman-Haken path-integral approach for the two-dimensional surface optical polaron bound to a Coulomb impurity. PMID- 9947550 TI - Excitons in one-phonon resonant Raman scattering: Deformation-potential interaction. PMID- 9947549 TI - Transient optical reflectivity from bounded nonlocal media: Normal incidence. PMID- 9947551 TI - Electron spin resonance in amorphous silicon doped with Gd. PMID- 9947552 TI - Spatial dispersion effects on the optical properties of an insulator-excitonic semiconductor superlattice. PMID- 9947554 TI - Semiconductor-quasimetal transition of heavily doped trans-polyacetylene. PMID- 9947553 TI - Structural determination of crystalline silicon by extended energy-loss fine structure spectroscopy. PMID- 9947555 TI - Asymptotic forms of electrostatic potentials in zero-band-gap semiconductors: Bulk versus surface screening. PMID- 9947556 TI - Electron-lattice-interaction-induced localization in semiconducting compounds. PMID- 9947557 TI - Diffuse scattering of x rays at grazing angles from near-surface defects in crystals. PMID- 9947558 TI - Resonance Raman scattering in GaAs/AlAs thin-layer superlattices under high pressure. PMID- 9947559 TI - Hot-carrier screening in semiconductors: A Boltzmann-equation approach. PMID- 9947560 TI - Quantum kinetic-equation approach to semiconductor hot-carrier screening. PMID- 9947562 TI - Calculation and interpretation of the electronic properties of superlattices. PMID- 9947561 TI - Bias-induced nonlinearities in the dc I-V characteristics of neutron transmutation-doped germanium at liquid-4He temperatures. PMID- 9947563 TI - Phonon-assisted optical absorption by excitons in semiconductor quantum wells. PMID- 9947564 TI - Energetics and valence-band offset of the CaF2/Si insulator-on-semiconductor interface. PMID- 9947565 TI - Impurity levels, impurity bands, excited impurity bands, and band tails: The electronic density of states in quantum wells and heterostructures. PMID- 9947566 TI - Excited states and their relaxation dynamics in trans-polyacetylene. PMID- 9947567 TI - "Hall crystal" versus Wigner crystal. PMID- 9947568 TI - Spin relaxation in type-II GaAs/AlAs quantum wells. PMID- 9947570 TI - Raman scattering in GaAs/AlAs superlattices with Fibonacci structure. PMID- 9947569 TI - Coherent electron focusing with quantum point contacts in a two-dimensional electron gas. PMID- 9947571 TI - Empirical tight-binding force model for molecular-dynamics simulation of Si. PMID- 9947572 TI - Silicon (111) 2 x 1 surface states: K-edge transitions and surface-selective L2,3VV Auger line shape. PMID- 9947573 TI - Evaluation of the temperature-dependent dielectric function in the valence band of zinc-blende-type semiconductors. PMID- 9947574 TI - Subbands and excitons in GaAs/Ga1-xAlxAs quantum wells with different shapes in an electric field. PMID- 9947575 TI - Chemical activity of hydrogen in a Si lattice. PMID- 9947576 TI - Far-infrared spectra of N2-Ar alloys. PMID- 9947577 TI - Low-energy electron diffraction study of incommensurate H2, HD, and D2 monolayers physisorbed on graphite. PMID- 9947578 TI - Dynamics of a frustrated rare-gas monolayer adsorbed on a MgO(100) substrate. PMID- 9947580 TI - Raman-scattering study of the Li+ and FA(Li+) centers in KBr. PMID- 9947579 TI - Numerical simulation of the optical spectra of Frenkel excitons in disordered systems. PMID- 9947581 TI - Phonon dispersion and lattice dynamics of KTaO3 from 4 to 1220 K. PMID- 9947582 TI - Pressure effects on Raman scattering from solid HF and DF. PMID- 9947583 TI - Deactivation of Al-M+ and Al-OH- centers in quartz by use of the Smoluchowski approach. PMID- 9947584 TI - Luminescence of Cr3+ in sillimanite. PMID- 9947585 TI - Onset of rigidity in Se1-xGex glasses: Ultrasonic elastic moduli. PMID- 9947586 TI - Staging properties of potassium-ammonia ternary graphite intercalation compounds at high ammonia pressure. PMID- 9947588 TI - Electronic structure and magnetism in VPt3. PMID- 9947587 TI - Role of rediffused primary electrons in secondary-electron ejection from a Cu(100) surface. PMID- 9947589 TI - Mesoscopic conductance fluctuations in the presence of spin-orbit coupling and Zeeman splitting. PMID- 9947590 TI - Angular dependence of the magnetoresistance of potassium films at 4.2 K. PMID- 9947591 TI - Optical enhancement of a cold-evaporated silver surface studied with second harmonic generation. PMID- 9947593 TI - Ultrasonic properties of quasi-one-dimensional blue bronze K0.3MoO3. PMID- 9947592 TI - Scattering of a surface-skimming bulk transverse wave by an elastic ridge. PMID- 9947594 TI - Resonant-tunneling lifetime comparison between double-barrier and delta -doped barrier structures. PMID- 9947596 TI - Impurity photoconductivity spectra of ZnGa2Se4:Co2+ single crystals. PMID- 9947595 TI - Excitons in ZnSe-ZnS strained-layer superlattices. PMID- 9947597 TI - Photodarkening in amorphous Ge1-xSnxSe2 films. PMID- 9947598 TI - Raman study of the incommensurate structural phase transition in BaMnF4. PMID- 9947599 TI - Mossbauer study of the Al-Fe decagonal phase. PMID- 9947600 TI - Resonant-tunneling effects in a parabolic quantum well obtained by application of crossed magnetic and electric fields in a semiconductor quantum barrier. PMID- 9947601 TI - Magnetoconductance measurements in the variable-range-hopping regime. PMID- 9947602 TI - Broken-dimer model in a-Si:H. PMID- 9947603 TI - Novel features of quantum conduction in a constriction. PMID- 9947604 TI - Doping-induced suppression of dislocation formation in semiconductors. PMID- 9947605 TI - Exact solutions for hydrogenic donor states in a spherically rectangular quantum well. PMID- 9947606 TI - Glass in a stretched state formed by negative-pressure vitrification: Trapping in and relaxing out. PMID- 9947607 TI - Optical-absorption and photoionization measurements from the excited states of Ce3+:Y3Al5O12. PMID- 9947608 TI - ESR of Mn2+ in AlCl3-graphite intercalated compounds. PMID- 9947609 TI - Electronic structure and positron annihilation in LaB6 and CeB6. PMID- 9947610 TI - EPR of VO2+-doped K2C2O4 PMID- 9947611 TI - Many-electron effects in L gamma 2,3 x-ray emission spectroscopy spectrum of BaO. PMID- 9947612 TI - Many-electron effects in L gamma 2,3 x-ray emission spectroscopy of rare-earth elements. PMID- 9947613 TI - Forward-backward transport theories of ion-solid interactions: Variational approach. PMID- 9947614 TI - Spatial instabilities and dislocation-loop ordering in irradiated materials. PMID- 9947615 TI - Correlations in disordered crystals and diffuse scattering of x rays or neutrons. PMID- 9947616 TI - Diffuse scattering of x rays or neutrons from binary alloys and null matrices. PMID- 9947618 TI - Spin dynamics and magnetic properties of two-dimensional systems MPX3 from 31P NMR and relaxation. PMID- 9947617 TI - Excited-state absorption of Cr3+ in LiCaAlF6: Effects of asymmetric distortions and intensity selection rules. PMID- 9947619 TI - Dissipation in two-fluid flow of HeII. PMID- 9947620 TI - Kosterlitz-Thouless transition in helium films. PMID- 9947621 TI - Transport properties of anisotropic superconductors: Influence of arbitrary electron-impurity phase shifts. PMID- 9947622 TI - Coupled two-order-parameter approach to granular superconductors. PMID- 9947623 TI - Gapless fermions and gauge fields in dielectrics. PMID- 9947625 TI - Exact calculation of the two-electron interaction in the ground state of the Hubbard model. PMID- 9947624 TI - Dissipative quantum mechanics of a particle in the washboard potential: Application to the Josephson junction. PMID- 9947626 TI - Transport studies of La2-xSrxCuO4 near the insulator-metal-superconductor transition. PMID- 9947627 TI - Determination of dopant site occupancies in Cu-substituted YBa2Cu3O7- delta by differential anomalous x-ray scattering. PMID- 9947628 TI - Calculation of Coulomb-interaction parameters for La2CuO4 using a constrained density-functional approach. PMID- 9947629 TI - Effect of grain boundaries on magnetic field penetration in polycrystalline superconductors. PMID- 9947631 TI - Reproducible magnetic features of high-Tc superconductors in weak fields. PMID- 9947630 TI - Theory of Raman scattering from gap excitations in weakly coupled high temperature superconductors. PMID- 9947632 TI - Resistivity changes and defect mobility in ion-irradiated YBa2Cu3O7-x. PMID- 9947634 TI - Preparation, characterization, and superconducting properties of tetragonal LaBaCaCu3O7+ delta. PMID- 9947633 TI - Oxygen in-diffusion processes in tetragonal YBa2Cu3O7-x oxide. PMID- 9947636 TI - Formation of the 110-K superconducting phase via the amorphous state in the Bi-Sr Ca-Cu-O system. PMID- 9947635 TI - Angle-resolved photoemission investigation of the electronic band properties of YBa2Cu3O7-x(001). PMID- 9947637 TI - Low-dimensional magnetic ordering and Ising- and XY-like anisotropy of Er3+ in the system ErBa2Cu3Ox with 6Ce3+ energy transfer in yttrium aluminum garnet. PMID- 9947871 TI - Exact theories for light, x-ray, electron, and neutron diffractions from planar media with periodic structures. PMID- 9947872 TI - Surface-extended x-ray-absorption fine-structure experiments at atmospheric pressure by means of a photocathode proportional counter with monolayer sensitivity. PMID- 9947873 TI - Structure of the energy spectrum for a two-dimensional quasicrystal: Perturbation method. PMID- 9947875 TI - Fermi surface in local-density-functional theory and in gradient expansions. PMID- 9947874 TI - Valence admixture in the EuxRh1-x amorphous alloys. PMID- 9947876 TI - Surface transverse elastic waves in N-layer superlattices. PMID- 9947877 TI - Long-range carrier-mediated Cu-Cu interactions and low-temperature transitions in the quasi-one-dimensional CuxNi1-x(phthalocyanine)I alloys. PMID- 9947878 TI - Pressure-induced neutral-to-ionic phase transition in organic charge-transfer crystals of tetrathiafulvalene-p-benzoquinone derivatives. PMID- 9947879 TI - Spectroscopy and transient photoconductivity of partially crystalline polyaniline. PMID- 9947880 TI - Diffraction of He and Ne from Ni(113): A comparative study. PMID- 9947881 TI - Nonlocal corrections to Fresnel optics: How to extend d-parameter theory beyond jellium models. PMID- 9947883 TI - Reduction of low-frequency noise in metals by a magnetic field: Observability of the transition between random-matrix ensembles. PMID- 9947882 TI - Internal oxidation of In and Cd impurities in silver. PMID- 9947884 TI - Photoemission studies of interface chemistry and Schottky barriers for ZnSe(100) with Ti, Co, Cu, Pd, Ag, Au, Ce, and Al. PMID- 9947885 TI - Low-temperature resistivity from electron-dual-phonon processes for alkali metals. PMID- 9947886 TI - Energetics of transition-metal alloy formation: Ti, Zr, and Hf alloyed with the heavier 4d and 5d elements. PMID- 9947887 TI - X-ray photoelectron diffraction study of perpendicular and tilted CO on clean and potassium-modified Ni(110). PMID- 9947889 TI - Theory of hydrogen diffusion and reactions in crystalline silicon. PMID- 9947888 TI - Quantum theory of transient transport in semiconductors: A Monte Carlo approach. PMID- 9947890 TI - Microscopic structure of the hydrogen-boron complex in crystalline silicon. PMID- 9947891 TI - Optical free-carrier absorption of an electron-hole plasma in silicon. PMID- 9947892 TI - Structural and electronic properties of arsenic chalcogenide molecules. PMID- 9947893 TI - Stimulated recombination in highly excited GaAs. PMID- 9947894 TI - Intersubband Auger recombination and population inversion in quantum-well subbands. PMID- 9947895 TI - Influence of the pair distribution function on the site dependence of donor properties in ZnSe. PMID- 9947896 TI - Theory of line shapes of exciton resonances in semiconductor superlattices. PMID- 9947897 TI - Variations of energy gap, resistivity, and temperature coefficient of resistivity in annealed beta -Ag2Se thin films. PMID- 9947898 TI - Determination of subband structure, depolarization shift, and depletion charge in an AlxGa1-xAs-GaAs heterostructure. PMID- 9947899 TI - Electro-optical effects in InxGa1-xAs/GaAs strained-layer superlattices. PMID- 9947900 TI - Scattering experiments in two-dimensional systems in the presence of quantizing magnetic fields. PMID- 9947902 TI - Effects of irradiation on elastic properties of TaS3. PMID- 9947901 TI - Optical investigations on the mobility of two-dimensional excitons in GaAs/Ga1 xAlxAs quantum wells. PMID- 9947904 TI - Calculation of the band gap for small CdS and ZnS crystallites. PMID- 9947903 TI - Photoinduced magnetization in dilute magnetic (semimagnetic) semiconductors. PMID- 9947905 TI - Diamagnetism as a probe of exciton localization in quantum wells. PMID- 9947906 TI - Anomalies in the cyclotron resonance in high-mobility GaAs-Ga1-xAlxAs heterojunctions. PMID- 9947908 TI - Effect of carrier-carrier interaction on intervalley transfer rates of photoexcited electrons in GaAs. PMID- 9947907 TI - Variational calculation of two-dimensional-polaron energy levels in a magnetic field. PMID- 9947909 TI - Hierarchical structure in quasicrystal diffraction patterns: X-ray scattering on periodic approximants of Fibonacci superlattices. PMID- 9947910 TI - Photoluminescence in (Ga,In)P at high pressure. PMID- 9947911 TI - Mott transition of the excitons in GaSe. PMID- 9947913 TI - Breathing-mode lattice relaxation accompanying emission and capture by deep electronic levels in silicon. PMID- 9947912 TI - Stability of group IV-VI semiconductor alloys. PMID- 9947914 TI - Multisubband photoluminescence in sawtooth doping superlattices. PMID- 9947915 TI - Phonon softening of amorphous semiconductor superlattice films. PMID- 9947916 TI - Properties of the electron-hole plasma in II-VI compounds as a function of temperature. PMID- 9947917 TI - Electronic structure of Si-skeleton materials. PMID- 9947918 TI - Extrinsic contributions to photoreflectance of AlxGa1-xAs/GaAs quantum wells: An investigation of the "donor-related" feature. PMID- 9947919 TI - Many-body theory of magneto-optical spectra in doped quantum wells. PMID- 9947920 TI - Bias-induced metastable transverse conduction in doping-modulated amorphous silicon superlattices. PMID- 9947921 TI - Comprehensive study of the valence band of standard alkali-metal and indium phosphorus oxide salts through x-ray photoemission spectroscopy and extended Huckel theory tight-binding analysis: A contribution towards the elucidation of local order in oxides on InP surfaces. PMID- 9947922 TI - Time scales and optical dephasing measurements: Investigation of dynamics in complex systems. PMID- 9947923 TI - Diffusion of tritons, deuterons, and protons in LiNbO3 crystals. PMID- 9947924 TI - Simulation of ionic transition-metal crystals: The cluster model and the cluster lattice interaction in the light of the theory of electronic separability. PMID- 9947925 TI - Raman scattering and photoluminescence in Cu2O under hydrostatic pressure. PMID- 9947926 TI - Study of the F band in mixed ionic crystals using discrete lattice models. PMID- 9947928 TI - Theoretical calculations of He scattering intensities from MgO. PMID- 9947927 TI - Crystal-field splitting of core excitons in ionic crystals. PMID- 9947929 TI - Surface structure of donor graphite intercalation compounds by scanning tunneling microscopy. PMID- 9947930 TI - Screening of the electron-ion potential in metals. PMID- 9947931 TI - 4f binding-energy shifts of the light-actinide dioxides and tetrafluorides. PMID- 9947933 TI - Transition of interband optical absorption in reduced-dimensional semiconductor structures. PMID- 9947932 TI - Duality in Fermi-level pinning at Cu/InP(110) and Ag/InP(110) interfaces. PMID- 9947934 TI - Relationship between the conductivity and the glass temperature for hopping systems. PMID- 9947935 TI - Thermal activation energy of steady-state photoconductivity in undoped amorphous silicon and silicon-germanium alloys. PMID- 9947936 TI - Resonant photoemission in single-crystal black phosphorus. PMID- 9947937 TI - Helium diffraction from the MgO(001) surface. PMID- 9947938 TI - Preparation and observation of Si10 clusters on a Au(001)-(5 x 20) surface. PMID- 9947939 TI - Collective intersubband resonances of inversion electrons on GaAs. PMID- 9947940 TI - Electron paramagnetic resonance of thermal donors in germanium. PMID- 9947941 TI - Electrical depopulation of double quantum wells. PMID- 9947942 TI - Threshold energy for photogeneration of self-trapped excitons in SiO2. PMID- 9947943 TI - Quantum oscillations and negative differential resistance in nonresonant magnetotunneling. PMID- 9947945 TI - Mechanisms for the optically detected magnetic resonance background signal in epitaxial GaAs. PMID- 9947944 TI - Phonon coupling and X- Gamma mixing in GaAs-AlAs short-period superlattices. PMID- 9947947 TI - Electron-spin resonance of Mn2+ in Ge-rich bismuth-modified amorphous semiconductors (Ge42S58)99.5-xBixMn0.5. PMID- 9947946 TI - Mesoscopic properties of on-facet AlxGa1-xAs/GaAs submicron channels. PMID- 9947948 TI - Optical Ramsey fringes in photochemical hole burning. PMID- 9947949 TI - Mossbauer spectrometry study of the hyperfine fields and electronic structure of Fe-Co alloys. PMID- 9947950 TI - Level-crossing effects in N,N-diethylmorpholinium tetracyanoquinodimethane. PMID- 9947951 TI - Interference effect in electron-energy-loss spectroscopy. PMID- 9947952 TI - Ion neutralization in stimulated desorption. PMID- 9947953 TI - Electron paramagnetic resonance of Cr(CN)63- in NaCl: Evidence for motion of the associated cation vacancies. PMID- 9947954 TI - Weak localization in tunnel junctions. PMID- 9947955 TI - Vacancies in solid 3He. PMID- 9947956 TI - Theory of the superfluid density tensor in unconventional superconductors: Impurity scattering and band-structure effects. PMID- 9947957 TI - Thermal expansion of monocrystalline heavy-fermion CeCu6. PMID- 9947958 TI - Theory of superconducting-quasiparticle interface states. PMID- 9947959 TI - Metal-superconductor supercurrents in the scanning tunneling microscope. PMID- 9947960 TI - Transient electrodynamic response of thin-film superconductors to laser radiation. PMID- 9947961 TI - Muon spin rotation in the magnetic and superconducting ground states of (U,Th)Be13 and (U,Th)Pt3. PMID- 9947962 TI - Power spectra of noise-induced hopping between two overlapping Josephson steps. PMID- 9947963 TI - Rotational states of H2, HD, and D2 on graphite. PMID- 9947964 TI - Intensities of Rv'(0) transitions in solid HD. PMID- 9947966 TI - Fluctuations of critical current and phase slippage in Josephson junctions. PMID- 9947965 TI - Induced dipole-moment function of HD. PMID- 9947967 TI - Infrared conductivity and electron-molecular-vibration coupling in the organic superconductor di PMID- 9947968 TI - Thermodynamic properties of impure anisotropic quasi-one-dimensional superconductors. PMID- 9947969 TI - Field structure of vortex lattices in uniaxial superconductors. PMID- 9947970 TI - Chiral spin states and superconductivity. PMID- 9947971 TI - Equivalence of fractional quantum Hall and resonating-valence-bond states on a square lattice. PMID- 9947973 TI - Properties of localized condensation on a ladder superconducting network. PMID- 9947972 TI - Green's functions for the Bloch electrons on coupled chains in a magnetic field. PMID- 9947974 TI - Pressure dependence of the superconducting and Neel temperatures in a La2CuO4+ delta crystal. PMID- 9947975 TI - Structural and dynamic properties of the magnetic order in the 90-K superconductor HoBa2Cu3O7. PMID- 9947976 TI - Crystallographic thermal expansion and elasticity across the superconducting transition in YBa2Cu3O7- delta. PMID- 9947977 TI - Phase diagram of the Hubbard model: A variational wave-function approach. PMID- 9947979 TI - Charge fluctuations between CuO2 layers in high-temperature superconductors. PMID- 9947978 TI - Flux creep in Y(Gd)Ba2Cu3O7- delta : Magnetic field dependence. PMID- 9947980 TI - Chemical states of Ba in YBa2Cu3O7- delta studied by x-ray photoelectron spectroscopy. PMID- 9947982 TI - Plasmon dispersion relations and the induced electron interaction in oxide superconductors: Numerical results. PMID- 9947981 TI - Superconductivity in sulfur-containing R-Ba-Cu-O compounds. PMID- 9947983 TI - Superconducting state in an oxygen hole metal. PMID- 9947984 TI - Nonlinear electrodynamics in the granular superconductor YBa2Cu3O7: Experiments and interpretation. PMID- 9947986 TI - Thermal conductivity of Bi-Sr-Ca-Cu-O superconductors: Correlation with the low temperature specific-heat behavior. PMID- 9947985 TI - Large-n limit of the Hubbard-Heisenberg model. PMID- 9947988 TI - Electronic structure of high-Tc cuprates from core-level photoemission spectroscopy. PMID- 9947987 TI - Conductivity and Hall coefficient in La2CuO4+y near the insulator-metal transition. PMID- 9947989 TI - Superconductivity originating from a repulsive potential: Proposal of a new exciton mechanism of high-Tc superconductivity in the dilute electron gas. PMID- 9947990 TI - Structure and magnetic properties of nonsuperconducting doped Co and Fe Bi2Sr2Cu1 xMxOy phases. PMID- 9947991 TI - Ion-beam-induced metal-insulator transition in YBa2Cu3O7- delta : A mobility edge. PMID- 9947992 TI - Distorted chain sites for Co- and Fe-substituted YBa2Cu3O7- delta. PMID- 9947993 TI - Vertex correction to the Eliashberg equation for the superconducting critical temperature. PMID- 9947994 TI - Vibronic pairing models for high-Tc superconductors. PMID- 9947995 TI - Assessment of Fermi-liquid description for the normal state of high-Tc superconductors. PMID- 9947996 TI - Orthorhombic distortion and cation ordering in Y2Ba4Cu8O16 and Er2Ba4Cu8O16 high Tc thin films. PMID- 9947997 TI - Superconductivity in a narrow-band system with intersite electron pairing in two dimensions. II. Effects of nearest-neighbor exchange and correlated hopping. PMID- 9947999 TI - Influence of Ni, Fe, and Zn substitution on the superconducting and antiferromagnetic state of YBa2Cu3O7- delta. PMID- 9947998 TI - Dynamic spin fluctuations and the bag mechanism of high-Tc superconductivity. PMID- 9948001 TI - Evidence of frustrated magnetism in CeAl3 from muon-spin-rotation spectroscopy. PMID- 9948000 TI - Reversible and irreversible magnetization in the high-Tc superconductor Tl2CA2Ba2CU3O10. PMID- 9948002 TI - Cellular dynamics during directional solidification: Interaction of multiple cells. PMID- 9948003 TI - Computer algorithm for many-body wave functions. PMID- 9948004 TI - Spin dynamics of Gd at high temperatures. PMID- 9948006 TI - Experimental study of phase separation in films of molecular dimensions. PMID- 9948005 TI - Structures of the commensurate phases in TaTe4. PMID- 9948007 TI - Evolution of a magnetic bubble after quantum nucleation. PMID- 9948009 TI - Grain-boundary ordering, segregation, and melting transitions in a two dimensional lattice-gas model. PMID- 9948008 TI - Critical behavior of an array of Josephson junctions with variable couplings. PMID- 9948010 TI - Magnetic phases of EuxSr1-xAs3 investigated by specific-heat, susceptibility, and elastic neutron-scattering measurements. PMID- 9948011 TI - Universality, low-temperature properties, and finite-size scaling in quantum antiferromagnets. PMID- 9948012 TI - Magnetization steps in dilute magnetic semiconductors to 55 T: Mn2+ pair saturation in Cd1-xMnxTe and steps in Zn1-xMnxSe, Zn1-xMnxTe, and Cd1-xMnxSe. PMID- 9948013 TI - Quantization conditions for the periodic Toda chain: Inadequacy of Bethe-ansatz methods. PMID- 9948014 TI - Stochastic theory of diffusional planar-atomic clustering and its application to dislocation loops. PMID- 9948015 TI - X-ray diffraction and equation of state of solid neon to 110 GPa. PMID- 9948017 TI - Random-walk simulation of diffusion-controlled processes among static traps. PMID- 9948016 TI - Sherrington-Kirkpatrick model in a transverse field: Absence of replica symmetry breaking due to quantum fluctuations. PMID- 9948018 TI - Vortices in the classical two-dimensional anisotropic Heisenberg model. PMID- 9948020 TI - Mode locking in quasicrystals. PMID- 9948019 TI - Magnetic behavior in Mg-stabilized bcc beta -Gd and beta -Dy. PMID- 9948021 TI - Field dependences of surface magnetization in a semi-infinite Ising model with a nonrandom surface or surface amorphization. PMID- 9948022 TI - Theory of the spin liquid state of the Heisenberg antiferromagnet. PMID- 9948024 TI - Electronic structure of CO adsorbed on small Cu clusters: Theoretical study on excited states. PMID- 9948023 TI - Low-field Hall effect near the percolation threshold. PMID- 9948025 TI - Coexistence curve of fluoroform near its critical point. PMID- 9948027 TI - Internal stress tensor in constant-pressure molecular dynamics of anisotropic molecular solids. PMID- 9948026 TI - Phase transition in type-1 fcc Ising antiferromagnets. PMID- 9948028 TI - Monte Carlo study of finite-size effects at a weakly first-order phase transition. PMID- 9948030 TI - Structure-related induced anisotropy in metallic glasses. PMID- 9948029 TI - Zero modes and the quantized Hall conductance of the two-dimensional lattice in a magnetic field. PMID- 9948032 TI - Transport properties of disordered continuum systems. PMID- 9948031 TI - Numerical study of late-stage coarsening for off-critical quenches in the Cahn Hilliard equation of phase separation. PMID- 9948034 TI - Four-dimensional description of the structure and phase transitions of KFeF4 (phase II and superstructure phase III). PMID- 9948033 TI - Monte Carlo renormalization-group study of spinodal decomposition: Scaling and growth. PMID- 9948035 TI - Magnetization by rotation and gyromagnetic gyroscopes. PMID- 9948036 TI - Effect of interlayer exchange coupling on spin-wave spectra in magnetic double layers: Theory and experiment. PMID- 9948037 TI - Theoretical approach to magnetic force microscopy. PMID- 9948039 TI - First-principles calculations of dynamic permeability in porous media. PMID- 9948038 TI - First-principles calculation of crystal-field parameters in Nd2Fe14B. PMID- 9948040 TI - Correlation and exchange of three-dimensional and quasi-two-dimensional electron gases in a strong magnetic field. PMID- 9948041 TI - Incommensurate phase of Te adsorbed on (001) GaAs. PMID- 9948042 TI - Spectroscopic spin-boson model in the adiabatic limit: Application to optical line shapes. PMID- 9948043 TI - Possibility of coexistence of local-moment and itinerant-electron magnetism in alpha -manganese: A perturbed-angular-correlation study. PMID- 9948044 TI - Pseudospinodal critical phenomena, renormalized instantons, and the one-loop equation of state. PMID- 9948046 TI - Smectic elastic constants of lamellar fluid membrane phases: Crumpling effects. PMID- 9948045 TI - Correlation functions of the Ising spin glass on the Bethe lattice. PMID- 9948047 TI - New disordered phase of a ferromagnetic binary Ising system. PMID- 9948049 TI - Molecular-dynamics study of phase transitions between incommensurate and commensurate phases. PMID- 9948048 TI - Spin-disorder effects in the electrical resistivity of Ni-based amorphous alloys. PMID- 9948051 TI - Thermal melting of arachidic acid monolayers in ultrathin multilayers: A high resolution x-ray diffraction study. PMID- 9948050 TI - Scaling approach to two-magnon excitations in quantum spin chains. PMID- 9948052 TI - Classical statistical mechanics of the nonlinear adiabatic shell model: Monatomic chain with quartic core-shell interaction. PMID- 9948053 TI - Correlated random walks on lattices: A solvable alternative to Fokker-Planck equations in periodic potentials. PMID- 9948054 TI - One-dimensional Ising ferromagnet PMID- 9948055 TI - Thermodynamics of spin glasses in the Hartree-Fock approximation. PMID- 9948056 TI - Effect of crystal fields on the Hall effect in Kondo-type systems. PMID- 9948057 TI - Hole motion in a quantum Neel state. PMID- 9948058 TI - Thermally activated methyl and t-butyl group reorientation in solids. PMID- 9948059 TI - Critical behavior of the static and dynamic correlation functions near the optical Anderson transition. PMID- 9948060 TI - Fractionization phenomenon in the sine-Gordon system. PMID- 9948061 TI - Tunneling alpha 2F( omega ) in thin-film Nb as a function of thickness. PMID- 9948062 TI - Superconducting energy gap in Coulomb staircase tunneling structures. PMID- 9948064 TI - Specific heat of Bi2Sr2CuO6 and Bi2Sr2CaCu2O8 in the superconducting state. PMID- 9948065 TI - Vibrating-reed studies on non-single-phase Bi-Ca-Sr-Cu-O superconducting ceramics. PMID- 9948063 TI - Thermodynamic fluctuations in the 110-K Bi-Sr-Ca-Cu-O superconductor: Evidence for two-dimensional behavior. PMID- 9948067 TI - Substitution-induced superstructures in Cu(1)-doped YBa2(Cu1-xMx)3O7 ceramic (M=trivalent cation). PMID- 9948066 TI - Fluctuation conductivity of Tl-Ba-Ca-Cu-O thin films. PMID- 9948068 TI - Gadolinium interaction in GdBa2Cu3Oy compounds. PMID- 9948069 TI - Hole pairing within an extended Anderson impurity model applicable to the high-Tc cuprates. PMID- 9948070 TI - Coexistence of antiferromagnetism and superconductivity in YBa2(CU1-xFex)3O7 only for x around 0.10. PMID- 9948071 TI - Model for local para-Cooperons possibly relevant for high-temperature superconductors. PMID- 9948072 TI - Quantum effects and competing interactions in crystals of the mixed rubidium and ammonium dihydrogen phosphate system. PMID- 9948073 TI - Spin disorder in paramagnetic fcc iron. PMID- 9948074 TI - Monte Carlo study of surface critical behavior in the XY model. PMID- 9948075 TI - Surface anisotropy and surface spin canting in the semi-infinite ferromagnet. PMID- 9948076 TI - Volume-change phase transition in solids at valence instability. PMID- 9948077 TI - Pair correlations for double-chain and triple-chain Ising models with competing interactions. PMID- 9948078 TI - Properties of magnetic superlattices with antiferromagnetic interfacial coupling: Magnetization, susceptibility, and compensation points. PMID- 9948079 TI - Pyroelectric detection of high-order commensurate phases with a narrow range of stability in betaine calcium chloride dihydrate. PMID- 9948080 TI - Comment on "Peierls instability in the two-dimensional half-filled Hubbard model" PMID- 9948081 TI - Reply to "Comment on 'Peierls instability in the two-dimensional half-filled Hubbard model' " PMID- 9948082 TI - Comment on "Crystal structure of lithium beryllium hydride" PMID- 9948084 TI - Reply to "Comment on 'Identification of a superoxide in superconducting La2CuO4+ delta by x-ray photoelectron spectroscopy' " PMID- 9948083 TI - Comment on "Identification of a superoxide in superconducting La2CuO4+ delta by x ray photoelectron spectroscopy" PMID- 9948085 TI - Comment on simple scaling theory for three-dimensional critical wetting with short-ranged forces. PMID- 9948087 TI - Erratum: Possibility of a common origin to ferroelectricity and superconductivity in oxides PMID- 9948086 TI - Erratum: Perturbation theory of superconducting micronetworks near the phase transition boundary PMID- 9948088 TI - Universality in two-point functions at wetting: Exact scaling function for energy density correlations. PMID- 9948089 TI - Ejection of excimers from the surface of solid argon upon exciton self-trapping. PMID- 9948090 TI - 35Cl spin-lattice relaxation and temperature-dependent phason gaps in substitutionally disordered incommensurate systems. PMID- 9948092 TI - X-ray study of in-plane epitaxy of YBa2Cu3Ox thin films. PMID- 9948091 TI - Superconductivity and spin-density waves in heavy-fermion systems. PMID- 9948093 TI - Nonlinear optical response of granular Y-Ba-Cu-O films. PMID- 9948094 TI - Direct measurements of the effects of inhomogeneities on the normal-state transport properties of YBa2Cu3O7-x thin films. PMID- 9948095 TI - Oxygen-diffusion-induced phase boundary migration in copper oxide thin films. PMID- 9948096 TI - Collective excitations in the normal state of Cu-O-based superconductors. PMID- 9948097 TI - Magnetic transitions in the system YBa2Cu2.8Co0.2O6+y. PMID- 9948099 TI - Preparation and Raman analysis of single-phase Y1-xPrxBa2Cu3O7- delta. PMID- 9948098 TI - Plasmons and interband transitions in Bi2Sr2CaCu2O8. PMID- 9948100 TI - High-energy spectroscopic study of YBa2Cu2.7Fe0.3O6.9 with photon energy near the O 1s threshold. PMID- 9948101 TI - Low-temperature specific heat of single-crystal Bi2CaSr2Cu2O8 and Tl2Ca2Ba2Cu3O10. PMID- 9948102 TI - ac conductivity of the strongly correlated Hubbard model in the low-temperature limit. PMID- 9948103 TI - New class of frustrated quantum spin systems with an exactly known ground state. PMID- 9948104 TI - Geometric scaling of the optical memory effect in coherent-wave propagation through random media. PMID- 9948105 TI - Monte Carlo studies of the critical free energies for the three-dimensional Ising model with surfaces, edges, and corners. PMID- 9948106 TI - Critical-like behavior in quantum adsorption. PMID- 9948107 TI - Novel stochastic approach for Gutzwiller matrix elements: Two-dimensional Hubbard model. PMID- 9948109 TI - Quantum dynamics of a pulsed spin system: Long-time behavior of semiclassical wave functions. PMID- 9948108 TI - Instabilities in the quantum Sherrington-Kirkpatrick Ising spin glass in transverse and longitudinal fields. PMID- 9948110 TI - Comparison of nonlinear optical responses of periodic and quasiperiodic superlattices. PMID- 9948111 TI - Brillouin scattering from unsupported Al films. PMID- 9948112 TI - Electron transport properties of amorphous (ZR0.64Ni0.36)1-xAlx alloys. PMID- 9948114 TI - Elastic constants of nickel: Variations with respect to temperature and pressure. PMID- 9948113 TI - First-principles potentials in modeling structure and thermodynamics of Fe-Ni alloys. PMID- 9948115 TI - Nuclear quadrupole interaction in glassy Hf1-xCux alloys and their local structures. PMID- 9948117 TI - Tight-binding models and density-functional theory. PMID- 9948116 TI - Effect of pressure and crystal structure on energy levels of Pr3+ in LaCl3. PMID- 9948118 TI - Extended x-ray-absorption fine-structure study of copper under high pressure. PMID- 9948119 TI - Crystal-field effects and magnetic behavior in RNi5 and RCo5+x rare-earth compounds. PMID- 9948120 TI - Alloy models with the embedded-atom method. PMID- 9948122 TI - Excitonic states in pure and impurity-doped magnesium oxide. PMID- 9948121 TI - High-frequency rectification in UPt3 point contacts. PMID- 9948123 TI - Theory of phonons in three- and four-layer superlattices. PMID- 9948124 TI - Phonon-mediated indirect interactions between adatoms on surfaces. PMID- 9948125 TI - Adsorbed layer and multilayer materials: The energetics and bonding of Pd and Ag on Nb(001) and Nb(110). PMID- 9948126 TI - Graphite under pressure: Equation of state and first-order Raman modes. PMID- 9948127 TI - Comparative study of angle-resolved valence-band photoemission from half monolayer structures of C, N, and O on Ni(100). PMID- 9948128 TI - Optical properties of In1-xGaxAsyP1-y alloys. PMID- 9948129 TI - Thermal amplitudes of surface atoms on Si(111) 2 x 1 and Si(001) 2 x 1. PMID- 9948130 TI - Si-P-H complexes in crystal silicon: A theoretical study. PMID- 9948132 TI - Interaction of optical phonons with a one-component plasma. PMID- 9948131 TI - Dispersive nature of hole transport in polyvinylcarbazole. PMID- 9948133 TI - Empirical application of Dyson's equation to the L2,3 soft-x-ray-emission transition densities of states of c-Si and a-Si:H. PMID- 9948135 TI - Fermi-level movement and atomic geometry at the Al/GaAs(001) interface. PMID- 9948134 TI - Metallization and Fermi-level movement at the Cs/GaAs(110) interfaces. PMID- 9948136 TI - Saturation of intersubband transitions in p-type semiconductor quantum wells. PMID- 9948137 TI - Coupled plasmon and phonon in the accumulation layer of InAs(110) cleaved surfaces. PMID- 9948138 TI - Noble-metal adsorption on Si(111): Medium-energy ion-scattering results for the Ag ( sqrt 3 x sqrt 3)R30 degrees reconstruction. PMID- 9948139 TI - Intrawell and interwell coupling of plasmons in multilayer modulation-doped GaAs/AlxGa1-xAs quantum wells. PMID- 9948140 TI - Probing the Co coordination at the Si/CoSi2(111) interface by photoemission. PMID- 9948141 TI - Magnetic-field-induced localization in degenerately doped n-type Ge. PMID- 9948142 TI - Generalized quantum Langevin equations for high-electric-field transport. PMID- 9948143 TI - Stochastic simulation of molecular-beam epitaxial growth of a model compound semiconductor: Effects of kinetics. PMID- 9948144 TI - Photoemission study of CaF2- and SrF2-GaAs(110) interfaces formed at room temperature. PMID- 9948145 TI - Band bendings, band offsets, and interface instabilities in p+-GaAs/n--ZnSe heterojunctions. PMID- 9948146 TI - Adsorption of potassium and oxygen on GaAs(110): Charge transfer and enhanced oxidation. PMID- 9948147 TI - Adsorption and interaction of Sb on Si(001) studied by scanning tunneling microscopy and core-level photoemission. PMID- 9948148 TI - Pressure dependence of deep electronic levels in semiconductors: Phosphorus vacancy pair (or Si E center) and divacancy in silicon. PMID- 9948149 TI - Alkali-metal-promoted oxidation of the Si(100)2 x 1 surface: Coverage dependence and nonlocality. PMID- 9948150 TI - Operator ordering in effective-mass theory. PMID- 9948151 TI - Ab initio pseudopotential calculations of optical-phonon deformation potentials in zinc-blende semiconductors. PMID- 9948152 TI - Femtosecond dynamics of excitonic absorption in the infrared InxGa1-xAs quantum wells. PMID- 9948153 TI - Resonant tunneling of holes in double-barrier heterostructures in the envelope function approximation. PMID- 9948155 TI - Hyperpolarizabilities of conjugated polymers. PMID- 9948156 TI - Electron self-energy in two dimensions. PMID- 9948154 TI - Effect of nonparabolicity in GaAs/Ga1-xAlxAs semiconductor quantum wells. PMID- 9948157 TI - Surface-phonon dispersion curves of KBr(001) via helium-atom scattering: Comparison with calculations. PMID- 9948158 TI - Surface phonon modes of the RbBr(001) crystal surface by inelastic He-atom scattering. PMID- 9948159 TI - Characterization of the water of crystallization in CsMnCl3 PMID- 9948160 TI - Structural models of glassy As2S3: Intermediate-range order and photostructural changes. PMID- 9948161 TI - Electronic properties of fractal-glass models. PMID- 9948162 TI - Polarons in acetanilide. PMID- 9948163 TI - Determination of the dielectric, piezoelectric, and elastic constants of crystals in class 32. PMID- 9948164 TI - Relativistic effects in the electronic structure of Cu{001} PMID- 9948165 TI - Universal energy-level statistics for disordered metals. PMID- 9948166 TI - Comparison of optimization methods for electronic-structure calculations. PMID- 9948167 TI - Sequential precursors in dissociative chemisorption: O2 on Pt(111). PMID- 9948168 TI - Observation of graphitic and amorphous structures on the surface of hard carbon films by scanning tunneling microscopy. PMID- 9948169 TI - Behavior of magnesium clusters under electron attachment and detachment. PMID- 9948170 TI - Phonon dispersion of bcc transition metals using the temperature-dependent pair potential. PMID- 9948172 TI - Direct-band-gap absorption in germanium under pressure. PMID- 9948171 TI - Electron-energy-loss spectra of the Si(100)-(2 x 1) surface exposed to NH3. PMID- 9948174 TI - Tunneling-controlled photoluminescence in nonresonantly coupled single quantum wells. PMID- 9948173 TI - Electronic and structural properties of a discommensurate monolayer system: GaAs(110)-(1 x 1)Bi. PMID- 9948175 TI - Multiphonon hopping of electrons on defect clusters in amorphous germanium. PMID- 9948177 TI - Filamentation instability of electromagnetic waves in compensated magnetoactive semiconductors. PMID- 9948176 TI - Direct observation of tunneling between Landau levels in barrier-separated two dimensional electron-gas systems. PMID- 9948178 TI - Binding energies of excitons in semiconductor quantum wells: Quantum subband interference effect. PMID- 9948179 TI - Subband structure of PbTe quantum wells. PMID- 9948180 TI - Directional emission of nonthermal halogen atoms by electron bombardment of alkali halides. PMID- 9948182 TI - Erratum: Calculation of the diamagnetic shift in resonant-tunneling double barrier GaAs/AlxGa1-xAs heterostructures PMID- 9948181 TI - Glass transition in computer-simulated iron. PMID- 9948184 TI - Defractalization of films adsorbed on fractal surfaces. PMID- 9948183 TI - Multiple lattice phases and polaron-lattice-spinless-defect competition in polyaniline. PMID- 9948185 TI - Effect of high-energy ion irradiation on the elastic moduli of Ag/Co superlattices. PMID- 9948186 TI - Electronic instabilities of the quasi-two-dimensional monophosphate tungsten bronze P4W12O44. PMID- 9948187 TI - Biexciton lifetime in CuCl observed with weak picosecond pulse excitation. PMID- 9948189 TI - Quasiclassical behavior of ballistic electrons in a perpendicular magnetic field. PMID- 9948188 TI - Dopant concentration dependences and symmetric Fermi-level movement for metal/n type and p-type GaAs(110) interfaces formed at 60 K. PMID- 9948190 TI - Bonding of Se and ZnSe to the Si(100) surface. PMID- 9948191 TI - Two types of conductance minima in electrostatic Aharonov-Bohm conductance oscillations. PMID- 9948192 TI - Population process of the upper subband in AlxGa1-xAs-GaAs quantum wells. PMID- 9948194 TI - Photoquenching and photoinduced-recovery properties of the EL2 defect in GaAs: Evidence against the identification of EL2 with the isolated AsGa defect. PMID- 9948193 TI - Outgoing multiphonon resonant Raman scattering and luminescence near the E0+ Delta 0 gap in epitaxial CdTe films. PMID- 9948196 TI - ac response of the charge-density-wave mode in K0.3MoO3. PMID- 9948195 TI - Origin of surface anisotropies in the optical spectra of III-V compounds. PMID- 9948197 TI - Extended interstitials in silicon and germanium. PMID- 9948198 TI - Optical transitions in ultra-high-purity zinc selenide. PMID- 9948199 TI - Density of states in a two-dimensional electron gas in the presence of a one dimensional superlattice potential. PMID- 9948200 TI - Carrier-induced transition from excitonic to free-carrier-like radiative recombination in a semiconductor quantum well studied by magnetoluminescence. PMID- 9948201 TI - Symmetry breaking in nitrogen-doped amorphous carbon: Infrared observation of the Raman-active G and D bands. PMID- 9948202 TI - Properties of D- centers in polar crystals. PMID- 9948204 TI - Calculated electronic structure and magnetic properties of Y-Fe compounds. PMID- 9948203 TI - Solid-state amorphization in Al-Pt multilayers by low-temperature annealing. PMID- 9948206 TI - Stationary waves in a nonlinear periodic medium: Strong resonances and localized structures. II. The continuous model. PMID- 9948205 TI - Stationary waves in a nonlinear periodic medium: Strong resonances and localized structures. I. The discrete model. PMID- 9948207 TI - Electromodulation of the surface-plasmon dispersion relation and adsorption of anions at the electrochemical interface. PMID- 9948208 TI - Relativistic Stoner theory applied to PuSn3. PMID- 9948209 TI - Density-functional approach to nonlinear-response coefficients of solids. PMID- 9948210 TI - Ion-surface interaction potentials from alkali-ion-metal scattering below 500 eV. PMID- 9948211 TI - Nonlocal corrections to Fresnel optics: Jellium-model calculations above the bulk plasmon threshold. PMID- 9948212 TI - Interpretation of the optical properties of Nb. PMID- 9948213 TI - Surface states on NiAl(110). PMID- 9948215 TI - Molecular dynamics of a dilute solution of hydrogen in palladium. PMID- 9948214 TI - Intensity correlation function for light elastically scattered from a randomly rough metallic grating. PMID- 9948216 TI - Electronic structure of finite or infinite systems in the tight-binding model with overlap. PMID- 9948217 TI - Computer simulation of exciton trapping in Cu2+-doped crystals of (CH3)4NMnCl3 and (CH3)4NMnBr3 : Significance of trap efficiency in one-dimensional systems. PMID- 9948218 TI - Calculation of the electronic work function of Cu and Ag from an extended jellium model. PMID- 9948220 TI - Current-density-functional theory and the de Haas-van Alphen effect. PMID- 9948219 TI - Surface structure of the C(0001)-(2 x 2)Cs system: Low-energy electron diffraction dynamical calculation. PMID- 9948222 TI - Surface state and surface resonance at the center of the surface Brillouin zone Gamma -bar of Cu{001} PMID- 9948221 TI - Temperature and concentration variation of the Hall coefficient in amorphous Y-Al alloys. PMID- 9948223 TI - Correlation and clustering in the optical properties of composites: A numerical study. PMID- 9948224 TI - Transition of a Si-As solution to the amorphous phase induced by pulsed-laser quenching. PMID- 9948225 TI - Hydrogen passivation of shallow acceptors and donors in c-Si: Comparisons and trends. PMID- 9948226 TI - Point defects in GaAs-Ga1-xAlxAs superlattices. PMID- 9948228 TI - Phonon-assisted tunneling in persistent-photocurrent decay. PMID- 9948227 TI - Ultrafast mobility in photoinjected polar semiconductors. PMID- 9948229 TI - Theoretical and experimental studies of the photoemission current from GaAs(110). PMID- 9948230 TI - Spectroscopic study of an acceptor confined in a narrow GaAs/AlxGa1-xAs quantum well. PMID- 9948232 TI - Optical excitation of the metastable EL2() level. PMID- 9948231 TI - Temperature dependence of the cyclotron-resonance linewidth in GaAs-Ga1-xAlxAs heterojunctions. PMID- 9948234 TI - Fermi-level pinning at nickel disilicide-silicon interface. PMID- 9948233 TI - Interface-structure analysis of amorphous semiconductor heterojunctions by in situ x-ray photoelectron spectroscopy. PMID- 9948235 TI - Structure of the 0.767-eV oxygen-carbon luminescence defect in 450 degreesC thermally annealed Czochralski-grown silicon. PMID- 9948237 TI - Jahn-Teller effect with the recursion method: Dipole-carrying states and the absorption spectrum of CdTe:Fe2+ PMID- 9948236 TI - Discrete and continuous disorder in superlattices. PMID- 9948238 TI - Conformational effects in organopolysilanes: A first-principles approach. PMID- 9948240 TI - Cathodoluminescence of defects in diamond films and particles grown by hot filament chemical-vapor deposition. PMID- 9948239 TI - Submillimeter study of the cyclotron-resonance linewidth in CdTe. PMID- 9948241 TI - Resonant Raman scattering and piezomodulated reflectivity of InP in high magnetic fields. PMID- 9948243 TI - Numerical simulations of hopping conductivity using nonflat densities of states. PMID- 9948244 TI - Hydrogen passivation studies on Pd-n-type-Si diodes. PMID- 9948242 TI - Theory of structure and hyperfine properties of anomalous muonium in elemental semiconductors: Diamond, silicon, and germanium. PMID- 9948246 TI - Position-dependent effective mass for inhomogeneous semiconductors. PMID- 9948245 TI - Order of the X conduction-band valleys in type-II GaAs/AlAs quantum wells. PMID- 9948247 TI - Site occupancy and valence state of optically active cobalt ions in yttrium iron garnet. PMID- 9948248 TI - Brillouin-scattering study of the orientational glass transition in (KCl)1 x(KCN)x mixed crystals. PMID- 9948249 TI - Experimental and theoretical studies of energy transfer in F-center-OH-(OD-) defect pairs in KCl. PMID- 9948252 TI - Electrical properties of a LiTaO3 single crystal. PMID- 9948250 TI - Thermal conductivity of amorphous materials above the plateau. PMID- 9948251 TI - Photoemission study of the valence-band electronic structure in FexO, Fe3O4, and alpha -Fe2O3 single crystals. PMID- 9948253 TI - Temperature dependence of elastic constants of some fluorite crystals. PMID- 9948254 TI - Thermal conductivity of deformed potassium chloride. PMID- 9948256 TI - Hall mobility of positive carriers in the semimetallic compound LiGa. PMID- 9948255 TI - Ab initio calculations of magnetic states of a Mo monolayer. PMID- 9948257 TI - High-order corrections to the image potential. PMID- 9948258 TI - Peak mobilities in low-symmetry silicon inversion layers. PMID- 9948259 TI - Tight-binding prediction of tetrahedral semiconductor ionization potentials. PMID- 9948260 TI - Piezoelectric scattering at low lattice temperatures. PMID- 9948261 TI - Observation of an intrinsic 5 x 5 reconstruction on the clean Si(111) surface. PMID- 9948262 TI - Fermi-level tuning in Y1-xUxPd3. PMID- 9948263 TI - Dependence of the light-hole-heavy-hole splitting on layer thickness and substrate orientation in GaAs-(GaAl)As single-quantum wells. PMID- 9948265 TI - Even-denominator quantum Hall effect and the hierarchy of spin-singlet nu =2/(2q+1) fluids. PMID- 9948264 TI - Density dependence of radiative and nonradiative recombination rates in a gated GaAs/Ga1-xAlxAs modulation-doped quantum well. PMID- 9948266 TI - Nonlocal resonant optical phonons and the local properties of ultrathin Ge layers on Si(100). PMID- 9948267 TI - Dissociation energies of shallow-acceptor-hydrogen pairs in silicon. PMID- 9948268 TI - Temperature dependence and anharmonicity of the Debye-Waller factor in sodium metal using Mossbauer gamma -ray diffraction. PMID- 9948269 TI - Magnetoresistance in thin palladium-carbon mixture films. PMID- 9948271 TI - First-principles calculation of impurity-solution energies in Cu and Ni. PMID- 9948270 TI - Difference-equation approach to the electronic structures of surfaces, interfaces, and superlattices. PMID- 9948272 TI - Modification of the surface electronic structure of Cu(111) by monolayer Ni adsorption and the effects on H2 chemisorption. PMID- 9948273 TI - Screw dislocations and spiral growth in quasicrystals. PMID- 9948274 TI - Contributions from two-particle scattering to the extraordinary Hall effect in Kondo systems. PMID- 9948276 TI - Equilibrium faceting shapes for quasicrystals. PMID- 9948275 TI - Luminescence R-line spectrum of ruby crystals shocked to 125 kbar along the crystal c axis. PMID- 9948277 TI - Molecular-dynamics simulations of shock-induced detonations in solids. PMID- 9948278 TI - Surface-plasmon energy shifts due to submonolayer molecular adsorption on silver and aluminum. PMID- 9948279 TI - Oxidative bonding of (0001) alpha -Al2O3 to close-packed surfaces of the first transition-metal series, Sc through Cu. PMID- 9948280 TI - Adsorbate-induced reconstruction of Rh(110)1 x 2-H. PMID- 9948281 TI - Transport phenomena in polymer-graphite composite materials. PMID- 9948282 TI - Symmetry-dependent alignment of the electron-spin polarization vector due to electronic band hybridization observed in photoemission from Ag(100). PMID- 9948283 TI - Spin-dependent correlations and thermodynamic functions for electron liquids at arbitrary degeneracy and spin polarization. PMID- 9948284 TI - Sample-dependent resolution in scanning tunneling microscopy. PMID- 9948285 TI - Resonance photoemission at the 2p excitation threshold of Ni{001} PMID- 9948287 TI - Internal oxidation after coimplantation of antimony and oxygen in silver. PMID- 9948286 TI - Numerical study of optical absorption in two-dimensional metal-insulator and normal-superconductor composites. PMID- 9948288 TI - Determination of AB crystal structures from atomic properties. PMID- 9948289 TI - Structural changes and crystallization of amorphous hydrogenated silicon generated by laser irradiation. PMID- 9948290 TI - Theoretical analysis of Raman spectra of finite-stage Si/Si-Ge Fibonacci superlattices. PMID- 9948291 TI - Magnetotunneling measurement of space-charge accumulation in delta -doped quantum wells. PMID- 9948292 TI - Applicability of the deformation-potential approximation to deep donors in silicon. PMID- 9948293 TI - Low-field transport coefficients in GaAs/Ga1-xAlxAs heterostructures. PMID- 9948295 TI - Energy levels and charge distributions of nonideal dangling and floating bonds in amorphous Si. PMID- 9948294 TI - Angle-resolved ultraviolet photoelectron spectroscopic study of Si(001)-(2 x 1)/K and Si(001)-(2 x 1)/Cs surfaces. PMID- 9948296 TI - Temperature dependence of the Urbach optical absorption edge: A theory of multiple phonon absorption and emission sidebands. PMID- 9948298 TI - Role of hydrogen in the formation of metastable defects in hydrogenated amorphous silicon. PMID- 9948297 TI - Weak localization of polaritons and the generation of phase-conjugated light waves. PMID- 9948300 TI - Simulations of adatom geometries on the Si(111) surface using a model potential. PMID- 9948299 TI - Hot-phonon effects and interband relaxation processes in photoexcited GaAs quantum wells. PMID- 9948302 TI - Dwell time and phase times for transmission and reflection. PMID- 9948301 TI - Importance of carrier-carrier scattering for the ambipolar transport of optically generated carriers in a thin semiconductor slab. PMID- 9948303 TI - Long-wavelength optical phonons in Zn1-xMnxSe. PMID- 9948304 TI - Potential model for silicon clusters. PMID- 9948306 TI - Dynamical simulation of molecular-beam epitaxial growth of a model crystal. PMID- 9948305 TI - Oscillatory behavior in the photoluminescence excitation and photoconductivity spectra of GaAs-AlAs superlattices. PMID- 9948307 TI - Optical second-harmonic generation from magnetized surfaces. PMID- 9948308 TI - Core-level photoemission measurements of valence-band offsets in highly strained heterojunctions: Si-Ge system. PMID- 9948309 TI - Aharonov-Bohm and quantum Hall effects in singly connected quantum dots. PMID- 9948311 TI - Diffusivity and solubility of Ni (63Ni) in monocrystalline Si. PMID- 9948310 TI - Motional binding in InAs with a realistic surface potential. PMID- 9948312 TI - Localized vibrational modes in superlattices. PMID- 9948313 TI - Structural phase transitions in chalcogenide glasses. PMID- 9948314 TI - Structural phase transitions in GaAs to 108 GPa. PMID- 9948315 TI - Saturation of a resonant phonon-band mode by far-infrared excitation. PMID- 9948316 TI - Effects of charge-density-wave depinning on the elastic properties of NbSe3. PMID- 9948317 TI - X-ray standing-wave and tunneling-microscope location of gallium atoms on a silicon surface. PMID- 9948319 TI - Temperature dependence of the nonradiative decay of the Na 2p core exciton in sodium halides. PMID- 9948318 TI - Deuterium diffusion and magnetic resonance investigations in LiTaO3 single crystals. PMID- 9948320 TI - Determination of the number of scatterers in a finite volume by the statistical analysis of scattered light intensity. PMID- 9948321 TI - Electronic- and vibrational-structure calculations in models of the compressed SiO2 glass system. PMID- 9948322 TI - Solid krypton: Equation of state and elastic properties. PMID- 9948323 TI - Correlation of the 5.0- and 7.6-eV absorption bands in SiO2 with oxygen vacancy. PMID- 9948324 TI - Intermediate-coupling polaron in a polar-crystal slab. PMID- 9948325 TI - Thermal-diffuse scattering of x rays by phasons. PMID- 9948326 TI - Phason velocities in TaS2 by x-ray diffuse scattering. PMID- 9948327 TI - Optical absorption spectra for silver spherical particles. PMID- 9948328 TI - Low-temperature photocurrent studies of electron-state coupling in asymmetric coupled quantum wells. PMID- 9948329 TI - Absence of discontinuity in the exchange-correlation potential in the band-gap problem at finite temperature. PMID- 9948330 TI - Structural compromise of the arsenic-terminated silicon (111) surface. PMID- 9948331 TI - Resonant tunneling spectroscopy of two coupled quantum wells. PMID- 9948332 TI - Elastic properties of SixSe1-x glasses. PMID- 9948334 TI - Thermal desorption, indirect lateral interactions, and the 2 pi resonance model of CO chemisorbed on transition metals. PMID- 9948333 TI - Normally unoccupied states on C(111) (diamond) (2 x 1): Support for a relaxed pi bonded chain model. PMID- 9948336 TI - Brillouin cross sections and localized phonons in CaF2/Si heterostructures. PMID- 9948335 TI - Erratum: Anisotropy and infrared response of the GaAs-AlAs superlattice PMID- 9948337 TI - Ferromagnetism versus antiferromagnetism of the Cr(001) surface. PMID- 9948339 TI - Growth and magnetic characterization of Mn films and superlattices on Ag(001). PMID- 9948338 TI - Interference of surface relaxations in unsupported thin films. PMID- 9948341 TI - Electronic structure of CeCu6 and LaCu6. PMID- 9948340 TI - Pseudoexcitons in mixed-valence metals. PMID- 9948342 TI - Evidence for spin splitting in InxGa PMID- 9948343 TI - Plasmons and phonons bound to neutral donors in semiconductor quantum-well structures. PMID- 9948344 TI - Shubnikov-de Haas oscillations in HgTe/CdTe superlattices grown by laser molecular-beam epitaxy. PMID- 9948345 TI - Quantized hole states detected by photoemission in ultrathin epitaxial CoSi2 films on Si(111). PMID- 9948346 TI - Magnetoplasma effects in a quasi-three-dimensional electron gas. PMID- 9948347 TI - Evidence of a magnetic-field-induced insulator-metal-insulator transition. PMID- 9948348 TI - Surface phonon frequencies and eigenvectors on Si(111) sqrt 3 x sqrt 3:Al. PMID- 9948349 TI - Sb-induced bulk band transitions in Si(111) and Si(001) observed in synchrotron photoemission studies. PMID- 9948350 TI - Excited states of the light- and heavy-hole free excitons observed in photoreflectance. PMID- 9948351 TI - Time-resolved Raman scattering of nonequilibrium LO phonons in GaAs quantum wells. PMID- 9948352 TI - Theory of the structure of high-pressure GaAs II. PMID- 9948353 TI - One-dimensional molecular-dynamics simulation of the detonation of nitric oxide. PMID- 9948354 TI - Band dispersion of an interface state: CaF2/Si(111). PMID- 9948355 TI - Multiplet contributions to the 2p3/2 x-ray photoemission spectrum of CuO. PMID- 9948356 TI - Angular distribution of photoelectrons from silver bromide and metallic silver through the Cooper minimum. PMID- 9948357 TI - Nonsymmorphic icosahedral space groups and their realization by tetrahedrally coordinated quasicrystals. PMID- 9948358 TI - Systematic approach to the calculation of the polarization-dependent (and polarization-averaged) general term of the curved-wave multiple-scattering series in the x-ray-absorption cross section. PMID- 9948359 TI - Thermal attenuation of satellite reflections in modulated structures. PMID- 9948360 TI - Dynamics of phase separation in a model for diffusion-limited crystal growth. PMID- 9948361 TI - Elastic energy of interaction of a point defect with a grain boundary. PMID- 9948362 TI - Thin-source concentration-dependent diffusion: A full solution. PMID- 9948363 TI - Spin-resolved photoemission from the (111) face of a platinum. PMID- 9948364 TI - Symmetry-restricted anharmonicities and the CsCl-to-7R martensitic structural phase transformation of the NixAl1-x system. PMID- 9948365 TI - Studies of copper valence states with Cu L3 x-ray-absorption spectroscopy. PMID- 9948367 TI - Multiplet-dependent wave functions from the local-spin-density approximation with self-interaction correction. PMID- 9948366 TI - Formation of an interfacial alloy and epitaxial bcc Cr layers on Au(100). PMID- 9948368 TI - Experimental evidence for room-temperature intermetallic compound formation at the Pd/Al interface. PMID- 9948369 TI - Surface corrugation and surface-polariton binding in the infrared frequency range. PMID- 9948370 TI - First-principles determination of the bulk phase diagram for body-centered tetragonal copper: Application to epitaxial growth of Cu on Fe{100} PMID- 9948371 TI - Metallic state of the free-electron gas within the self-interaction-corrected local-spin-density approximation. PMID- 9948372 TI - Percolative c(2 x 2) adlayer structure in nonequilibrium adsorption models. PMID- 9948373 TI - Oxygen 2s spectroscopy. PMID- 9948375 TI - Hydrogen-induced phase separation in amorphous Cu0.5Ti0.5 alloys. III. Computer simulation studies. PMID- 9948374 TI - Effective electron-electron interaction in metals and superconductors. PMID- 9948376 TI - Electronic structure of the NiSi2(111) surface: Disorder effects. PMID- 9948377 TI - Effect of elastic tension on the electrical resistance of HfTe5 and ZrTe5. PMID- 9948378 TI - Dimer-adatom-stacking-fault (DAS) and non-DAS (111) semiconductor surfaces: A comparison of Ge(111)-c(2 x 8) to Si(111)-(2 x 2), -(5 x 5), -(7 x 7), and -(9 x 9) with scanning tunneling microscopy. PMID- 9948379 TI - Silicon electron-nuclear double-resonance study of the NL10 heat-treatment center. PMID- 9948380 TI - Phonon coupling to core spectra in homopolar semiconductors. PMID- 9948381 TI - Oscillatory photoconductivity and photomagnetoresistance in the diluted magnetic semiconductor Cd1-xMnxTe. PMID- 9948383 TI - Dynamical theory of transport phenomena in solids based on their electronic dielectric properties. PMID- 9948382 TI - New theoretical approach of transition-metal impurities in semiconductors. PMID- 9948384 TI - Densities of vibrational states in isotopically substituted polyacetylene by the renormalization-group technique. PMID- 9948385 TI - Resonant Raman studies of confined LO modes and interface modes in a small-period GaAs/AlAs superlattice. PMID- 9948386 TI - Correspondence between the dependence of frequencies and intensities of GaAs and AlAs longitudinal-optical modes on the photon energy in a thin-layer GaAs-AlAs superlattice. PMID- 9948387 TI - Density-functional calculation of the parameters in the Anderson model: Application to Mn in CdTe. PMID- 9948388 TI - Effect of temperature on the electron distribution in illuminated heterostructures. PMID- 9948389 TI - InSb(100) reconstructions probed with core-level photoemission. PMID- 9948390 TI - Velocity versus temperature relation for solidification and melting of silicon: A molecular-dynamics study. PMID- 9948391 TI - Anisotropic superexchange and spin-resonance linewidth in diluted magnetic semiconductors. PMID- 9948392 TI - Atomic arrangement and electronic structure of BC2N. PMID- 9948393 TI - Hole trapping, light soaking, and secondary photocurrent transients in amorphous silicon. PMID- 9948394 TI - Buildup of III-V-compound semiconductor heterojunctions: Structural and electronic properties of monolayer-thick III-V overlayers on III-V substrates. PMID- 9948396 TI - Vibrational Raman studies of amorphous solid interfaces. PMID- 9948395 TI - Electronic structure of AlAs-GaAs superlattices. PMID- 9948397 TI - Infrared quenching of persistent photoconductivity in GaAs/AlxGa1-xAs heterostructures. PMID- 9948398 TI - Interface response and rescaling approach to the eigenvectors of layered composite systems. I. Double-layer slab. PMID- 9948399 TI - Interface response and rescaling approach to the eigenvectors of layered composite systems. II. Triple-layer slab. PMID- 9948400 TI - Zero-resistance state in GaAs-Ga1-xAlxAs heterojunctions: Evidence for nearest neighbor hopping processes. PMID- 9948401 TI - Long-wavelength phonons in TlSbS2. II. Raman-active modes under hydrostatic pressure. PMID- 9948402 TI - Possibility of finding reliable solid-state tight-binding parameters for the Si-N bond through quantum-chemistry calculations. PMID- 9948403 TI - Lattice dynamics of isolated carbon in GaAs. PMID- 9948405 TI - Band lineups and deformation potentials in the model-solid theory. PMID- 9948404 TI - Phonon-wind-driven transport of photoexcited carriers in a semiconductor quantum well. PMID- 9948406 TI - Application of the linear muffin-tin-orbital band-structure method to calculate optical properties of solids. PMID- 9948407 TI - Calculation of optical properties of trans-polyacetylene by the linear muffin-tin orbital method. PMID- 9948408 TI - Defect structure of doped CaF2 at high temperatures. PMID- 9948410 TI - Metal-nonmetal transition induced by reorientation of the fluorine molecules in stage-2 graphite-fluorine compounds. PMID- 9948409 TI - Defect structure in transition-metal monoxides. PMID- 9948411 TI - Kramers-Kronig dispersive analysis and optical properties in the infrared, and revised vibrational behavior of orthorhombic Na2 PMID- 9948412 TI - Origin of the plateau in the low-temperature thermal conductivity of silica. PMID- 9948413 TI - Fractional quantum Hall effect in two-layered systems. PMID- 9948415 TI - Work function of Pt(111). PMID- 9948414 TI - Polarized curved-wave extended x-ray-absorption fine structure: Theory and application. PMID- 9948416 TI - Quasicrystalline Ti-Ni-Fe-Si: Mossbauer indications for high transition-metal site symmetry. PMID- 9948418 TI - Why solids are not really crystalline. PMID- 9948417 TI - Susceptibility line shape of a field-induced two-dimensional hole gas. PMID- 9948419 TI - Generalized model for the optical absorption edge in a-Si:H. PMID- 9948420 TI - Modified Thomas-Fermi theory for depletion and accumulation layers in n-type GaAs. PMID- 9948422 TI - Eu2+-->Mn2+ energy transfer in monocrystalline NaCl and NaBr. PMID- 9948421 TI - Photoemission studies of the metal-nonmetal transition of sodium on solid ammonia. PMID- 9948423 TI - Comment on "Quasicrystal structure of rapidly solidified Ti-Ni-based alloys" PMID- 9948425 TI - Reply to "Comment on 'Atomic model for the EL2 defect in GaAs" PMID- 9948424 TI - Comment on "Atomic model for the EL2 defect in GaAs" PMID- 9948426 TI - Exchange interaction in type-II quantum wells. PMID- 9948427 TI - Identification of a trigonal cation antisite defect in gallium arsenide. PMID- 9948428 TI - Resonant hyper-Raman scattering due to the forbidden LO phonon in SrTiO3. PMID- 9948430 TI - Nuclear spin-lattice relaxation times for mixtures of ortho- and para-H2: High ortho-H2 concentration. PMID- 9948429 TI - Optical dephasing, hyperfine structure, and hyperfine relaxation associated with the 580.8-nm 7F0-5D0 transition of europium in Eu3+:Y2O3. PMID- 9948431 TI - Electronic excitation spectra and energy losses of slow ions in solids. PMID- 9948433 TI - Low-temperature localized motion of hydrogen and electronic structure transition in hexagonal-close-packed scandium. PMID- 9948432 TI - Deuteron NMR and a model for phase transitions in monoclinic RbD2PO4. PMID- 9948434 TI - Initial state effects in deep inelastic neutron scattering. PMID- 9948436 TI - Mn2+ EPR study of phase transitions in dicalcium lead propionate Ca2Pb(C2H5COO)6: Determination of critical exponent below the ferroelectric phase transition and comparison with EPR studies on Ca2Ba(C2H5COO)6 and Ca2Sr(C2H5COO)6. PMID- 9948435 TI - Stage-III recovery in alpha -iron studied by means of nuclear magnetic resonance on oriented 131I nuclei. PMID- 9948438 TI - Technique for measuring the elementary pinning force in thin films. PMID- 9948437 TI - Secondary electron emission by channeled positrons and electrons. PMID- 9948439 TI - Tunneling in artificial Al2O3 tunnel barriers and Al2O3-metal multilayers. PMID- 9948441 TI - Path-integral simulation of the superfluid transition in two-dimensional 4He. PMID- 9948440 TI - Electromagnetic response of disordered superconductors. PMID- 9948442 TI - Angle dependence of the upper critical field of superconducting superlattices. PMID- 9948443 TI - Resistance anomaly near the localized-delocalized crossover point in the CeSix system. PMID- 9948444 TI - Fermi-surface geometry and pressure effects on the spin-fluctuation contributions to the specific heat: Anisotropic spin-fluctuation model for heavy-fermion UPt3. PMID- 9948446 TI - Localization of shear horizontal surface acoustic waves on a disordered surface. PMID- 9948445 TI - Van Hove correlation functions for identical fermions. PMID- 9948448 TI - Thermal detection of flux-flow noise in type-II superconductors. PMID- 9948447 TI - Theory of superconducting wire networks and Josephson-junction arrays in magnetic fields. PMID- 9948449 TI - Gutzwiller approximation for the Emery model. PMID- 9948450 TI - Ultrasonic attenuation investigation of the reentrant superconductor Er0.705H0.295Rh4B4. PMID- 9948451 TI - Shock-vortex interaction in superfluid helium. PMID- 9948452 TI - Quasispin-operator description of the Josephson tunnel junction and the Josephson plasma frequency. PMID- 9948453 TI - Specific heat of a d-wave superconductor stabilized by antiferromagnetic fluctuations. PMID- 9948455 TI - Phenomenological theory of the superconductivity phase diagram of U1-xThx PMID- 9948454 TI - Quasi-one-dimensional disordered bipolaronic superconductor. PMID- 9948456 TI - First-principles calculation of the superconducting gap function due to electron electron interaction for YBa2Cu PMID- 9948459 TI - Competing order parameters for increased Tc in "polytype" multilayer Cu-O systems. PMID- 9948457 TI - Neutron crystal-field spectroscopy and magnetic properties of DyBa2Cu3O7- delta. PMID- 9948458 TI - Temperature dependence of the critical current in high-Tc superconductors. PMID- 9948461 TI - Infrared study of anisotropy in single-crystal La2-xSrxCuO4. PMID- 9948460 TI - Raman-active phonons in the high-temperature superconductors and results in Bi2Sr2CuO6. PMID- 9948462 TI - Photoemission study of Bi2(Sr,Ca)3Cu2Oy. PMID- 9948463 TI - Point-contact tunneling in monophasic and polyphasic Y-Ba-Cu-O samples: Experiment and model. PMID- 9948465 TI - Theory of nuclear relaxation in superconducting high-Tc oxides. PMID- 9948464 TI - Oxygen isotope study of YBa2Cu3O7. PMID- 9948466 TI - Raman study of pure and doped (Li,Sr) single crystals of La2CuO4-y. PMID- 9948467 TI - Cyclic four-spin exchange on a two-dimensional square lattice: Possible applications in high-Tc superconductors. PMID- 9948469 TI - Quadrupolar relaxation and hopping motion of oxygen in YBa2Cu3O7-x. PMID- 9948468 TI - Angle-resolved photoemission from epitaxial YBa2Cu3O7-x(001) films. PMID- 9948470 TI - Hall coefficients and optical properties of La2-xSrxCuO4 single-crystal thin films. PMID- 9948471 TI - Cu nuclear quadrupole resonance of YBa2Cu3Ox with varying oxygen content. PMID- 9948472 TI - Synthesis and magnetic properties of the Bi-Sr-Ca-Cu oxide 80- and 110-K superconductors. PMID- 9948473 TI - Successive antiferromagnetic phase transitions in single-crystal La2CoO4. PMID- 9948475 TI - Multiple superconducting transition in ceramic YBa2Cu3O7- delta. PMID- 9948474 TI - Two-dimensional quantum Heisenberg antiferromagnet at low temperatures. PMID- 9948476 TI - Relaxation-time enhancement in the heavy-fermion systems CePd3 and UPt3. PMID- 9948477 TI - Conformal invariance and critical behavior of the O(n) model on the honeycomb lattice. PMID- 9948478 TI - Cascade effects in a nonequilibrium phase transition with metallurgical relevance. PMID- 9948479 TI - Molecular theory for the rheology of glasses and polymers. PMID- 9948480 TI - Ferromagnetic instability in the heavy-electron compound URu2Si2 doped with Re or Tc. PMID- 9948482 TI - Magnetic susceptibility and low-temperature heat capacity of CePd3B0.3. PMID- 9948481 TI - Dielectric and polarization measurements on BaTiO3 at high pressures to the tricritical point. PMID- 9948483 TI - Determination of effective-pair interactions in random alloys by configurational averaging. PMID- 9948484 TI - Neutron spin-echo study of sodium nitrite near the incommensurate transition. PMID- 9948485 TI - Thermodynamics of freezing in two dimensions: The compressibility of monolayer xenon on graphite. PMID- 9948486 TI - Elastic softening versus amorphization in a simple model of ion-induced radiation damage. PMID- 9948488 TI - Ground-state properties of the two-dimensional antiferromagnetic Heisenberg model. PMID- 9948487 TI - Dynamics of incommensurate structures and inelastic neutron scattering. PMID- 9948489 TI - Critical behavior of n-->0 gauge-invariant theory: Self-avoiding random surfaces. PMID- 9948490 TI - Simulated growth of wetting films with a conserved order parameter. PMID- 9948491 TI - Amplitude-mode polaritons in the incommensurate phase of quartz. PMID- 9948492 TI - Microwave conductivity of pinned spin-density waves and charge-density waves. PMID- 9948493 TI - Monte Carlo studies of slow relaxation in diluted antiferromagnets. PMID- 9948494 TI - Raman study of the alpha --> beta structural phase transition of solid N2. PMID- 9948495 TI - Ferromagnetism in hexagonal-close-packed elements. PMID- 9948497 TI - Magnetic dimensional resonances in Fe3O4 spheres. PMID- 9948496 TI - Role of noise in the initial stage of solidification instability. PMID- 9948498 TI - Weak localization in normal-metal loops: Influence of boundary conditions. PMID- 9948499 TI - 133Cs nuclear magnetic resonance study of one-dimensional fluctuations in CsH2PO4 and its ferroelectric and antiferroelectric transitions at high pressure. PMID- 9948500 TI - Crystal-field excitations in CeX2Si2 (X=Au, Ag, Pd, and Ru). PMID- 9948501 TI - Spin-(1/2 antiferromagnetic XXZ chain: New results and insights. PMID- 9948503 TI - P-T-H phase diagram of heavy-electron UCd11. PMID- 9948502 TI - Magnetic properties of the diluted magnetic semiconductor Zn1-xFexSe. PMID- 9948505 TI - Magnetic properties of interacting copper trimer systems. PMID- 9948504 TI - Magnetic excitations in semiconductor superlattices. PMID- 9948507 TI - Finite-size effects in Heisenberg antiferromagnets. PMID- 9948506 TI - Collective excitations in anisotropic ferromagnetic-nonmagnetic superlattices. PMID- 9948508 TI - Critical and paramagnetic spin fluctuations in Heisenberg magnets. PMID- 9948509 TI - Wetting in a two-dimensional random-bond Ising model. PMID- 9948510 TI - Diffusion in the Lennard-Jones glass model studied by equilibrium and nonequilibrium molecular dynamics. PMID- 9948511 TI - Compressibility and stability of icosahedral Al-Mn up to 28 GPa. PMID- 9948513 TI - Generalized master equations from the nonlinear Schrodinger equation and propagation in an infinite chain. PMID- 9948512 TI - Eu2CuO4: An anisotropic Van Vleck paramagnet. PMID- 9948514 TI - Dynamic structure factor for the Fibonacci-chain quasicrystal. PMID- 9948515 TI - Scaling and multiscaling laws in random fuse networks. PMID- 9948516 TI - Surface impurity problem in the Hubbard model: A renormalization-group study. PMID- 9948517 TI - Surface trapping of excitons in rare-gas solids. PMID- 9948518 TI - Difference in ranges of positrons and electrons in rare-earth metals. PMID- 9948519 TI - Antisymmetric part of the dynamic structure function of liquid 4He. PMID- 9948520 TI - Model-independent bounds for the potential and kinetic energy of liquid 4He at zero temperature. PMID- 9948521 TI - Observation of the persistent-current splitting of a third-sound resonator. PMID- 9948523 TI - Normal modes and nonlinear effects in Josephson arrays. PMID- 9948522 TI - van der Waals study of liquid-vapor coexistence in 4He. PMID- 9948524 TI - Pressure effect on superconducting transition-temperature relaxation behavior of the Zr70Cu30 amorphous alloy on annealing at elevated pressures. PMID- 9948525 TI - New type of superconductivity in very high magnetic fields. PMID- 9948526 TI - Slope of specific-heat jump at Tc in a very strong-coupling superconductor. PMID- 9948527 TI - Tunneling inversion with an excitonic contribution. PMID- 9948528 TI - Superconductivity in YBa1.95Cs0.05Cu3O7-y granular ceramics. PMID- 9948529 TI - Particle-size and temperature dependence of microwave noise in superconducting YBa2Cu3O7-y: Evidence for random Josephson junctions. PMID- 9948530 TI - Unoccupied electronic structure of single-crystal La2CuO4. PMID- 9948531 TI - Superconductivity and acoustic plasmons in the two-dimensional electron gas. PMID- 9948532 TI - Observation of trapped O2 in high-Tc metal oxide superconductors. PMID- 9948534 TI - X-ray, neutron-, and electron diffraction study of the incommensurate structure in single cystals of Bi2.2Sr1.9CaCu2O8+x. PMID- 9948533 TI - Muon-spin-rotation measurement of magnetic field penetration and flux pinning in superconducting EuBa2Cu3Ox. PMID- 9948535 TI - Correspondence between two-dimensional bosons and a bulk superconductor in a magnetic field. PMID- 9948536 TI - Enhancement of Cu-O vibrational modes and superconductivity in YBa2Cu3O7- delta studied by x-ray photoelectron spectroscopy and high-resolution electron-energy loss spectroscopy. PMID- 9948537 TI - Oxygen-deficiency dependence of the thermopower of YBa2Cu3O7-y. PMID- 9948538 TI - Fluctuation conductivity of high-Tc superconductors. PMID- 9948539 TI - Calculation of Raman- and infrared-active modes of Bi2CaSr2Cu2O8. PMID- 9948540 TI - Noise in the microwave absorption of YBa2Cu3O7- delta. PMID- 9948541 TI - c-axis thermal expansion of the Tl2Ba2CaCu2Ox superconductor. PMID- 9948543 TI - Oxygen stoichiometry, disordering, and the orthorhombic-to-tetragonal transition in YBa2Cu3O7- delta. PMID- 9948542 TI - Anisotropic electronic Raman scattering in untwinned YBa2Cu3O7- delta. PMID- 9948544 TI - Local structure distortion in a YBa2-0.52Sr0.52Cu3O7 superconductor. PMID- 9948546 TI - Evidence of Josephson junctions in sintered YBa2Cu3O7 samples by means of microwave absorption in a low magnetic field. PMID- 9948545 TI - Zero resistance up to 162 K in a multiphase Tl-Ca-Ba-Cu-O system. PMID- 9948547 TI - Superparamagnetic relaxation in Co0.7Cu0.15Fe0.15Cr2S4. PMID- 9948548 TI - Two-layer film of Fe(CO)5 adsorbed on a (0001) graphite plane: Mossbauer studies. PMID- 9948549 TI - Phase transition in random-anisotropy magnets. PMID- 9948551 TI - Critical behavior of the SU(3) ferromagnetic Heisenberg chain. PMID- 9948550 TI - Effective-medium theory for the fracture of fractal porous media. PMID- 9948553 TI - Effect of finite size on magnetoresistance. PMID- 9948552 TI - Computer studies of magnetization for amorphous Fe1-xZrxHy alloys. PMID- 9948554 TI - Observation of a metastable state in monolayers of carbon tetrafluoride on graphite. PMID- 9948556 TI - 1/n expansion for quantum Heisenberg antiferromagnets. PMID- 9948555 TI - Electron correlations in one dimension: The Hubbard model. PMID- 9948557 TI - Specific heat of disordered Xe films at low temperatures. PMID- 9948558 TI - Linear dichroism study of the structural phase transition of BaMnF4. PMID- 9948559 TI - Flory formula as an extended law of large numbers. PMID- 9948560 TI - Comment on a mean-field theory of quantum antiferromagnets. PMID- 9948561 TI - Current-driven plasma instabilities in superconductors. PMID- 9948563 TI - New paramagnetic center in amorphous silicon doped with rare-earth elements. PMID- 9948562 TI - Calculation of the paramagnetic host spin-lattice relaxation time from impurity ion EPR linewidth. PMID- 9948564 TI - Observation of the localized Si dangling-bond Pb defect at the Si/Si3N4 interface. PMID- 9948565 TI - Static and dynamic spin fluctuations in superconducting La2-xSrxCuO4. PMID- 9948566 TI - Bulk modulus and its pressure derivative of YBa2Cu3O7-x. PMID- 9948567 TI - Fermi-liquid versus non-Fermi-liquid behavior in a two-band model of high temperature superconductivity. PMID- 9948569 TI - Flux expulsion and penetration in superconducting YBa2Cu3O7- delta. PMID- 9948568 TI - Mean-field calculation for the weak ferromagnetic transition in La2-xSrxCuO4. PMID- 9948570 TI - Two-dimensional Heisenberg antiferromagnet with next-nearest-neighbor coupling. PMID- 9948572 TI - Calculated photoemission, inverse photoemission, and x-ray emission spectra of high-Tc superconductors: Tl2Ba2CaCu2O8 and Tl2Ba2Ca2Cu3O10. PMID- 9948571 TI - Reaction of Rb and oxygen overlayers with single-crystalline Bi2Sr2CaCu2O8+ delta superconductors. PMID- 9948573 TI - Magnetostriction of single-crystal La2CuO4. PMID- 9948574 TI - Static and dynamic Cu NMR tensors of YBa2Cu3O7- delta. PMID- 9948575 TI - Quantized topological point defects in two-dimensional antiferromagnets. PMID- 9948576 TI - Effect of Ag on the surface barrier for depletion of oxygen from polycrystalline YBa2Cu3O7 oxides. PMID- 9948577 TI - Hole concentrations, Hall number, and Tc relationships in substituted YBa2Cu3Oy. PMID- 9948579 TI - Critical current density obtained from particle-size dependence of magnetization in YBa2Cu3O7- delta powders. PMID- 9948578 TI - Superconductivity above 77 K in the R-Tl-Sr-Ca-Cu-O system (R represents rare earths). PMID- 9948580 TI - Attractive interactions from repulsive forces in a multiband Hubbard model. PMID- 9948582 TI - Extraordinary effect of aluminum substitution on the upper critical field of Ba2YCu3O7. PMID- 9948581 TI - Resonant inverse photoemission of Bi2Ca1+xSr2-xCu2O8+y and YBa2Cu3O7-x, unoccupied oxygen states, and plasmons. PMID- 9948583 TI - Temperature dependence of lower critical fields in Y-Ba-Cu-O crystals. PMID- 9948585 TI - Solvable models of corner wetting in two and three dimensions. PMID- 9948584 TI - Fermi-surface instabilities of a generalized two-dimensional Hubbard model. PMID- 9948587 TI - Current conservation and the nonlinear sigma model in mesoscopic systems. PMID- 9948586 TI - Percolation and phase transitions of hard-core particles on lattices: Monte Carlo approach. PMID- 9948589 TI - Magnetically driven lattice instabilities. PMID- 9948588 TI - Superconducting pairing of holes in the antiferromagnetic state of the two dimensional Hubbard model. PMID- 9948590 TI - Experimental Fermi surface of Mo(011). PMID- 9948591 TI - Force-balance theory of resistivity. PMID- 9948592 TI - Divergences in the force-balance theory of resistivity. PMID- 9948593 TI - Adiabatic and isothermal resistivities. PMID- 9948594 TI - Calculated electronic structure of Au13 clusters. PMID- 9948595 TI - Structural phase stability in lithium to ultrahigh pressures. PMID- 9948596 TI - Antilocalization and electron-electron interaction in thin granular palladium carbon mixture films. PMID- 9948597 TI - Persistence of the Au(100)-(1 x 1) M-bar3 surface state at the Cr/Au(100) interface: Epitaxial growth of a gold-chromium alloy. PMID- 9948599 TI - Fermi-surface structure of potassium in the charge-density-wave state. PMID- 9948598 TI - Noise and ac-dc interference phenomena in the charge-density-wave conductor K0.3MoO PMID- 9948600 TI - Static electric polarizabilities and collective resonance frequencies of small metal clusters. PMID- 9948601 TI - Structural phase transitions with little phonon softening and first-order character. PMID- 9948602 TI - Golden-rule approach to the soft-x-ray-absorption problem. V. Thermal broadening and comparison with experiments in quantum wells. PMID- 9948603 TI - Low-temperature properties of an Yb impurity in a metallic host with an axial crystalline field. PMID- 9948604 TI - Optical second-harmonic generation with grating-coupled surface plasmons from a quartz-silver-quartz grating structure. PMID- 9948606 TI - Phonon spectra of alkali metals in real space. PMID- 9948605 TI - Quantum oscillations in the point-contact magnetoresistance. PMID- 9948607 TI - Theory of ortho-para conversion in hydrogen adsorbed on metal and paramagnetic surfaces at low temperatures. PMID- 9948609 TI - Optical absorption of linear-chain gold complexes under pressure: AuX2 dibenzylsulfide (X2=Cl2,Br2,ClBr). PMID- 9948610 TI - Local environment of arsenic impurities in semi-insulating polycrystalline silicon. PMID- 9948608 TI - Adsorption distance of S on Ni(001): An electron-energy-loss-spectroscopy cross section analysis of the Ni(001)-c(2 x 2)S system. PMID- 9948612 TI - Resonant tunneling in zero-dimensional nanostructures. PMID- 9948611 TI - Photoluminescence spectra of oxygen-doped ZnSe grown by molecular-beam epitaxy. PMID- 9948614 TI - Theoretical phase stability of incommensurable spin structures on the {001} surfaces of MnO-type antiferromagnetic semiconductors. PMID- 9948613 TI - Optical characterization of a deep (Cu-C)-related complex defect in GaP. PMID- 9948615 TI - Brillouin-zone integration by Fourier quadrature: Special points for superlattice and supercell calculations. PMID- 9948617 TI - Effect of pressure on the optical absorption in GaP and GaxIn1-xP (x=0.36 and 0.5). PMID- 9948616 TI - Isoelectronic delta doping in a ZnSe superlattice: Tellurium as an efficient hole trap. PMID- 9948618 TI - Equilibrium theory of strained epitaxial layers. PMID- 9948620 TI - Optical detection of electron-nuclear double resonance for a donor in oxygen doped GaP. PMID- 9948619 TI - Theory of relative native- and impurity-defect abundances in compound semiconductors and the factors that influence them. PMID- 9948622 TI - Core-level photoemission studies of the alpha -Sn/InSb(100) heterostructure system. PMID- 9948621 TI - Optical transitions involving unconfined energy states in InxGa PMID- 9948623 TI - Cyclotron resonance of a magnetopolaron in a semiconductor quantum well. PMID- 9948625 TI - Stability of the strained-layer superlattice (GaP)1/(InP)1 (001). PMID- 9948624 TI - Infrared absorption properties of the EL2 and the isolated AsGa defects in neutron-transmutation-doped GaAs: Generation of an EL2-like defect. PMID- 9948627 TI - Pressure dependence of structural and electronic properties of polysilane alloys. PMID- 9948626 TI - Resonance Raman scattering induced by interface roughness in a short-period GaAs/Ga1-xAlxAs superlattice. PMID- 9948628 TI - Cr, Co, Pd, Au, and In overlayers on PbS(100): Adatom interactions and interface formation. PMID- 9948629 TI - Inelastic mean free paths for electrons at disordered interfaces. PMID- 9948630 TI - Band gaps and spin-orbit splitting of ordered and disordered AlxGa1-xAs and GaAsxSb1-x alloys. PMID- 9948632 TI - Pseudopotential approach to long-period narrow-gap superlattices. PMID- 9948631 TI - Quasiparticle lifetime of excited carriers in a semiconductor superlattice. PMID- 9948633 TI - Electronic structures and doping of InN, InxGa1-xN, and InxAl1-xN. PMID- 9948634 TI - Hydrogen-related center with tetrahedral symmetry in ion-implanted silicon. PMID- 9948635 TI - Nonlinear refractive index of optical crystals. PMID- 9948636 TI - First-principles calculation of the shock-wave equation of state of isotopic lithium hydrides. PMID- 9948639 TI - Anharmonic resonant modes and the low-temperature specific heat of glasses. PMID- 9948637 TI - High-temperature phase transitions in LiKSO4. PMID- 9948638 TI - X-ray absorption spectroscopy on solid krypton up to 20 GPa. PMID- 9948640 TI - Correlation satellites in deep metal 3p core x-ray photoemission of tetravalent oxides MO2 (M=Ce,Pr,Tb,Hf) and of LaF3. PMID- 9948641 TI - Exact asymptotic behavior of the charge and spin susceptibilities in an interacting Fermi liquid. PMID- 9948643 TI - Surface extended x-ray-absorption fine-structure spectroscopy measurement using the evanescent-wave effect of fluorescent x rays. PMID- 9948644 TI - Ab initio pseudopotential solid-state calculations of highly electronegative first-row elements. PMID- 9948642 TI - Cr-Gd exchange coupling constants in Cr-doped GdAlO3. PMID- 9948646 TI - Evidence of anomalous intermediate-range ordering in superionic borate glasses from neutron diffraction. PMID- 9948645 TI - Ground- and excited-state impurity bands in quantum wells. PMID- 9948647 TI - Comment on "Time-resolved photoluminescence of Fe3+ ions in fluorozirconate glass" PMID- 9948648 TI - Erratum: Short-range order in a partially crystallized Fe0.86B PMID- 9948649 TI - Luttinger parameters for GaAs determined from the intersubband transitions in GaAs/AlxGa PMID- 9948650 TI - Mean-field analysis of two antiferromagnetically coupled Anderson impurities. PMID- 9948651 TI - Localization-dependent thermalization of excitons in GaAs/AlxGa1-xAs quantum wells. PMID- 9948652 TI - Fluctuations in submicrometer semiconducting devices caused by the random positions of dopants. PMID- 9948654 TI - Pressure dependence of the Pb center at the <111> Si/SiO2 interface. PMID- 9948653 TI - Resonant tunneling in a transverse magnetic field: Transition from the electric to the magnetic quantum limit. PMID- 9948655 TI - Phase-coherent control of photocurrent directionality in semiconductors. PMID- 9948657 TI - Soliton contributions to the third-order susceptibility of polyacetylene. PMID- 9948656 TI - Magnetic field studies of elastic scattering and optic-phonon emission in resonant-tunneling devices. PMID- 9948658 TI - Effect of under- and overcoordination on the electronic structure of amorphous silicon. PMID- 9948659 TI - Neutralization of noble-gas ions at very low energies. PMID- 9948660 TI - Characterization of the incommensurate phase of PMID- 9948661 TI - Shadow-cone-enhanced secondary-ion mass-spectrometry studies of Ag{110} PMID- 9948663 TI - Theory of Auger core-valence-valence processes in simple metals. I. Total yields and core-level lifetime widths. PMID- 9948662 TI - pi -d backbonding band dispersion and final-state effects for the (2 x 1) p2mg phase of CO on Ni(110). PMID- 9948664 TI - Theory of Auger core-valence-valence processes in simple metals. II. Dynamical and surface effects on Auger line shapes. PMID- 9948665 TI - Calculation of Coulomb interaction strengths for 3d transition metals and actinides. PMID- 9948666 TI - Effects of the dispersion of sizes in the dielectric response of composites. PMID- 9948667 TI - Classical versus quantum models of charge-density-wave depinning in quasi-one dimensional metals. PMID- 9948668 TI - Multipole vibrations of small alkali-metal spheres in a semiclassical description. PMID- 9948670 TI - Elastic constants of the beta -Cu-Zn alloy system: A Monte Carlo study. PMID- 9948669 TI - Multipolar expansions for the empty-lattice problem. PMID- 9948671 TI - Half-integer and integer quantum-flux periods in the magnetoresistance of one dimensional rings. PMID- 9948672 TI - Computation of total and partial structure factors, coordination number, and compressibility with self- and mutual-diffusion coefficients of Hg-In alloy. PMID- 9948673 TI - ac conductivity of emeraldine polymer. PMID- 9948675 TI - Far-infrared absorption by aluminum small particles. PMID- 9948674 TI - Microwave transport in the emeraldine form of polyaniline. PMID- 9948676 TI - Exact results for the scattering of electromagnetic waves with a nonlinear film. PMID- 9948678 TI - Diffuse inelastic scattering of atoms from surfaces. PMID- 9948677 TI - Electronic structure of HfN0.93(100) studied by angle-resolved photoemission. PMID- 9948679 TI - Structural, thermal, and magnetic properties of icosahedral Al-Cr-Mn-Si alloys. PMID- 9948680 TI - Model for a vibrating disordered binary alloy. PMID- 9948681 TI - Incipient oxidation of magnesium: A high-resolution electron-energy-loss and photoemission study. PMID- 9948682 TI - Influence of misfit and bonding on the mode of growth in epitaxy. PMID- 9948684 TI - Formation of Frohlich bipolarons. PMID- 9948683 TI - Renormalization-group method for studying the spectra of disordered square lattices. PMID- 9948686 TI - Local density of states in double-barrier resonant-tunneling structures. II. Finite-width barriers. PMID- 9948685 TI - Comparative photoemission study of the adsorption of NO2, N2O, and NH3 on a-Si surfaces at low temperature. PMID- 9948687 TI - Picosecond photoinduced-absorption studies of band-tail thermalization in hydrogenated amorphous silicon-carbon alloys. PMID- 9948688 TI - Spectroscopy of bound excitons in cubic ZnS at moderate to high excitation densities. PMID- 9948689 TI - Transient photoconductivity in Ge:Be due to Be+ formation. PMID- 9948691 TI - Simulation of silicon clusters and surfaces via tight-binding molecular dynamics. PMID- 9948690 TI - Raman scattering on periodic Fibonacci superlattices: The building up of a quasiperiodic order. PMID- 9948692 TI - Optical third-harmonic generation in polyacetylene. PMID- 9948693 TI - Optical studies of bonding in coevaporated amorphous silicon-tin alloys. PMID- 9948694 TI - Initial stages of oxygen adsorption on Si(111): The stable state. PMID- 9948695 TI - Transport properties of polycrystalline Tl0.33MoO3 compounds. PMID- 9948697 TI - Valence-band levels and optical transitions in quantum wells in a parallel magnetic field. PMID- 9948696 TI - Electronic structure of Ge/Si monolayer strained-layer superlattices. PMID- 9948698 TI - Fermi-Dirac statistics and the nature of the compensating donors in boron-doped diamond layers. PMID- 9948699 TI - Harmonic generation of Alfven and helicon waves in semiconductors. PMID- 9948700 TI - Transmission spectroscopy on sawtooth-doping superlattices. PMID- 9948702 TI - Subband-Landau-level coupling in GaAs/Ga1-xAlxAs heterojunctions. PMID- 9948701 TI - Exact quantum-mechanical propagator for an electron in a saddle-point potential and a magnetic field. PMID- 9948703 TI - Electronic properties of micro-n-i-p-i structures in silicon. PMID- 9948704 TI - Photoemission spectroscopy of heterojunctions of hydrogenated amorphous silicon with silicon oxide and nitride. PMID- 9948705 TI - Influences of particle-hole Hartree interaction on magnetoresistances in disordered two-dimensional hole systems. PMID- 9948706 TI - Anomalous asymmetry of the electric field gradient at the Ti site in Ba2(Ti0.95Hf0.05) (Ge2xSi2-2x)O8 ceramics measured by perturbed-angular correlation spectroscopy. PMID- 9948707 TI - Temperature-dependent Raman study of ammonium perchlorate single crystals: Evidence for NH4+ quantum rotation below 30 K. PMID- 9948708 TI - Multiphonon dephasing of the 1086-cm-1 mode in calcite. PMID- 9948709 TI - Comparison of the interactions of H2 and rare-gas atoms with surfaces of insulators. PMID- 9948710 TI - Phenomenological piezoelectricity of polymer insulators. PMID- 9948711 TI - Electron-irradiation effects on the infrared absorption properties of the EL2 defect in GaAs. PMID- 9948712 TI - Spectral representation for the polarizability of a collection of dielectric spheres. PMID- 9948713 TI - Structure factor of alkaline-earth metals: Evaluation through the charged-hard sphere approximation. PMID- 9948715 TI - Dispersion relation for coupled surface plasmon and surface optical-phonon waves in polar semiconductors for some finite geometries. PMID- 9948714 TI - Connection between topology and pi -electron structure in amorphous carbon. PMID- 9948716 TI - Hydrogen vibrations in CdS. PMID- 9948717 TI - Analytic solution for the metal-insulator transition in a one-dimensional conductor. PMID- 9948718 TI - Dependence of energy shifts on the field direction in a graded Ga1-xAlxAs quantum well. PMID- 9948720 TI - Ultrasonic-phase-velocity measurements in electron-irradiated quartz. PMID- 9948719 TI - Selective adsorption in 4He-MgO scattering. PMID- 9948721 TI - Comment on "Luminescence of fused silica: Observation of the O2- emission band" PMID- 9948722 TI - Transient transport in a quasi-one-dimensional hopping model with a power-law distribution of transition rates. PMID- 9948723 TI - Onset of surface corrugation in molecular scattering from Ag(111). PMID- 9948724 TI - Atomic and electronic structure of the Na/Si(001)-2 x 1 surface. PMID- 9948725 TI - Resonant quasiconfined optical phonons in semiconductor superlattices. PMID- 9948726 TI - Ultraviolet photoemission study of the initial adsorption of Pb on Si(100)2 x 1. PMID- 9948727 TI - Grating-assisted Raman scattering of plasmons in layered two-dimensional electron systems. PMID- 9948728 TI - Effects of high atom densities on the NMR relaxation times in solid T2 and DT. PMID- 9948729 TI - Planar channeling in superlattices: Resonance channeling. PMID- 9948730 TI - Spontaneous interfacial polarization transfer between 19F and 1H. PMID- 9948731 TI - Two-dimensional angular correlation of annihilation radiation study of positron interactions with surfaces of aluminum. PMID- 9948732 TI - Two-dimensional physisorbed N2 on grafoil studied by positron annihilation spectroscopy. PMID- 9948733 TI - EPR studies of a new family of organic conductors: Dimethyl(ethylenedithio)diselenadithiafulvalene compounds (DMET)2X PMID- 9948734 TI - Electron paramagnetic resonance study of Fe3+ in alpha -quartz: Hydrogen compensated center. PMID- 9948735 TI - First-principles study of the conduction-electron-mediated interactions between nuclear spins in copper metal. PMID- 9948736 TI - Theory of deep inelastic neutron scattering. II. Application to normal and superfluid 4He. PMID- 9948737 TI - Population dynamics of a Bose gas near saturation. PMID- 9948738 TI - NMR investigation of the electronic structure of expanded liquid cesium. PMID- 9948740 TI - Reexamination of magnetic effects in the Bose gas. PMID- 9948739 TI - Fluorescence and magnetic resonance spectra of Nd3+ and Er3+ ions in single crystals of LaCl3. PMID- 9948741 TI - Critical properties of the Z(p)-symmetric spin models from an exact finite lattice approach. PMID- 9948742 TI - Calculation of the phase diagram of 3He-4He solid and liquid mixtures. PMID- 9948744 TI - Possibility of the vortex-antivortex transition temperature of a thin-film superconductor being renormalized by disorder. PMID- 9948743 TI - Influence of local correlations on dynamical susceptibilities of electronic systems. PMID- 9948745 TI - Isotope effects and pressure dependence of the Tc of superconducting stoichiometric PdH and PdD synthesized and measured in a diamond anvil cell. PMID- 9948747 TI - Vibrational analysis of tetragonal La2-xMxCuO4 (M=Sr,Ba). PMID- 9948746 TI - Crystal-field splittings in the cubic Heusler alloys HoPd2Sn and ErPd2Sn. PMID- 9948748 TI - Polaronic state of electrons on the surface of liquid-helium films: A self consistent treatment. PMID- 9948750 TI - Superconducting classes of heavy-fermion materials. PMID- 9948749 TI - Determination of the perpendicular penetration depth in superconducting thin films from the observation of nonuniform supercurrent flow. PMID- 9948751 TI - Spin dynamics of CeX2Si2 (X=Au, Pd, Rh, Ru). PMID- 9948752 TI - Low-temperature properties of an almost-localized Fermi liquid. PMID- 9948753 TI - Superfluid 3He-B in a weak link. PMID- 9948754 TI - 3He as an almost-localized Fermi liquid: The superfluid transition temperature. PMID- 9948755 TI - Density profile of the weakly interacting Bose gas confined in a potential well: Nonzero temperature. PMID- 9948757 TI - Pauli limiting of the upper critical magnetic field. PMID- 9948756 TI - Density profile of the weakly interacting Fermi gas confined in a potential well: Nonzero temperature. PMID- 9948758 TI - Correlation between electronegativity and superconductivity. PMID- 9948759 TI - Superconducting and normal-state properties of La1.85Sr0.15Cu1-xGaxBO4. PMID- 9948760 TI - c-axis stress dependence of normal and superconducting state properties of YBa2Cu3O7. PMID- 9948761 TI - Tight-binding Hamiltonians for high-temperature superconductors and applications to coherent-potential-approximation calculations of the electronic properties of La2-xBaxCuO4-y. PMID- 9948763 TI - In-plane paraconductivity in a single crystal of superconducting YBa2Cu3O7-x. PMID- 9948762 TI - Magnetic-field-dependent microwave properties of YBa2Cu3Ox single crystals. PMID- 9948765 TI - Mossbauer isomer-shift anomalies in a superconductor. PMID- 9948764 TI - dc transport and optical conductivity in a resonating-valence-bond crystal. PMID- 9948766 TI - Exact two-particle effective interaction and superconductivity in the two-level Hubbard model. PMID- 9948767 TI - Oxygen isotope effects in yttrium-barium-copper oxides. PMID- 9948768 TI - Magnetic ordering in the high-temperature superconductor ErBa2Cu3O7- delta. PMID- 9948769 TI - Photoelectron energy-loss study of the Bi2CaSr2Cu2O8 superconductor. PMID- 9948770 TI - Phase transformations in YBa2Cu3O7- delta. PMID- 9948771 TI - Phonon Raman scattering in (La1-xSrx)2CuO4 single crystals. PMID- 9948772 TI - Bismuth cuprate high-Tc superconductors using cationic substitution. PMID- 9948773 TI - Neutron scattering study of soft optical phonons in La2-xSrxCuO4-y. PMID- 9948775 TI - Dynamic spin susceptibility in the resonant-valence-bond state in high-Tc superconductors. PMID- 9948774 TI - Monte Carlo simulations of a disordered, three-dimensional system of Josephson junctions. PMID- 9948777 TI - Phenomenological description of piezoresistivity in semiconducting perovskite ferroelectrics. PMID- 9948776 TI - Magnetic neutron scattering study of single-crystal cupric oxide. PMID- 9948778 TI - Evidence for a phase transition in the zero-temperature anisotropic two dimensional Heisenberg antiferromagnet. PMID- 9948779 TI - Parametric excitation of Walker modes in ferromagnetic spheres. PMID- 9948780 TI - In situ study of staging disorder in cesium-intercalated graphite. PMID- 9948782 TI - Metamagnetism in La2CuO4. PMID- 9948781 TI - Late stages of spinodal decomposition in a three-dimensional model system. PMID- 9948783 TI - Two-magnon contribution to the ferromagnetic resonance linewidth in amorphous ferromagnetic metals. PMID- 9948784 TI - Field distributions and tricritical points in a random-field Ising model: Mean field renormalization-group approach. PMID- 9948785 TI - Specific heat of the random-field Ising system Fe0.46Zn0.54F2. PMID- 9948786 TI - New Li2-xCuxFeS2 (0 <= x <= 1) and CuxFeS2 (~0.25 <= x <= 1) phases. PMID- 9948787 TI - Critical x-ray scattering at the Peierls transition of the blue bronze. PMID- 9948788 TI - Monte Carlo study of the quantum spin-(1/2 Heisenberg antiferromagnet on the square lattice. PMID- 9948790 TI - Percolation renormalization-group calculations of equations of state for the Potts model. PMID- 9948789 TI - Melting of a free bilayer. PMID- 9948791 TI - Field-enhanced disorder in a ferromagnet with random-axis anisotropy. PMID- 9948792 TI - Raman activation of acoustic modes in commensurate A2BX4 crystals by zone folding. PMID- 9948794 TI - Goldstone and amplitude modes in incommensurate systems studied by 35Cl nuclear quadrupole resonance. PMID- 9948793 TI - Ground-state energy of the d=1,2,3 dimensional Hubbard model in the weak-coupling limit. PMID- 9948795 TI - Theory of photoinduced structure changes. PMID- 9948796 TI - Weak localization effects in the amorphous alloys V1-xXx (X=Si,Ge,Sn). PMID- 9948797 TI - Multicritical points in the magnetic phase diagrams of axial and planar antiferromagnets. PMID- 9948798 TI - Internal oscillation frequencies and anharmonic effects for the double sine Gordon kink. PMID- 9948800 TI - Critical-point wetting near grain boundaries and defect planes. PMID- 9948799 TI - Effective conductivity of anisotropic two-phase composite media. PMID- 9948801 TI - Exact mapping of the resonant-valence-bond state to a classical O(4) model in a logarithmic potential: Mean-field theory, magnetic correlations, and excitations. PMID- 9948802 TI - Current distribution in random resistor networks. PMID- 9948803 TI - Nonlinear oscillations in electrochemical growth of Zn dendrites. PMID- 9948804 TI - Computer simulations of epitaxial growth. PMID- 9948805 TI - Long-range order without broken symmetry: Two-dimensional Heisenberg antiferromagnet at zero temperature. PMID- 9948806 TI - Monte Carlo study of the spin-1 antiferromagnetic chain with both bilinear and biquadratic exchange interactions. PMID- 9948807 TI - Finite-size scaling theory for domain growth in the time-dependent Ginzburg Landau model: Layered system. PMID- 9948808 TI - Magnetic scattering in AuCo and AgCo with weak localization. PMID- 9948809 TI - New growth model: The screened Eden model. PMID- 9948810 TI - Transport properties of CoCl2-graphite intercalation compounds. PMID- 9948811 TI - Analysis of small-angle scattering patterns from precipitating alloys. PMID- 9948812 TI - Destruction of chiral ordering by a random field in the f=1/2 frustrated XY model. PMID- 9948813 TI - Nonlinear behavior and 1/f noise near a conductivity threshold: Effects of local microgeometry. PMID- 9948814 TI - Magnetic line groups. II. Corepresentations of the magnetic line groups isogonal to the point groups Cn, S2n, and Cnh. PMID- 9948815 TI - Correlation functions of one-dimensional quantum systems. PMID- 9948816 TI - Gutzwiller dynamic susceptibility: Consequences for the transport properties of transition metals. PMID- 9948817 TI - Ground-state morphology of random frustrated XY systems. PMID- 9948819 TI - Ferromagnetic q=4,5 Potts models on the two-dimensional Penrose and square lattices. PMID- 9948818 TI - Fulton-Gouterman ground states for soft tunneling systems. PMID- 9948821 TI - Microwave absorption of a superconducting lead sphere. PMID- 9948820 TI - Generalized Smoluchovski equation with gelation. PMID- 9948822 TI - High-temperature lattice-liquid in-plane structure of LiC6: A neutron scattering study. PMID- 9948823 TI - Superfluid transition of 4He films adsorbed on multiply connected surfaces. PMID- 9948824 TI - Pressure dependence of superconductivity in amorphous ZrxNi100-x alloys. PMID- 9948826 TI - Two-band model with an occupation-influenced hopping rate: Kondo enhancement and superconductivity. PMID- 9948825 TI - Size difference of anisotropic muonium relaxation rates in n- and p-type semiconductors. PMID- 9948827 TI - Incommensurate superlattices in the Pb-substituted Bi-Sr-Ca-Cu-O superconductors. PMID- 9948828 TI - Superconductivity in the Tl-Nd-Sr-Cu-O and the Tl-Pb-Nd-Sr-Cu-O systems. PMID- 9948829 TI - Tunneling measurements on Bi2CaSr2Cu2O8. PMID- 9948830 TI - Effect of annealing in oxygen on the structure formation of Bi-Sr-Ca-Cu-O thin films. PMID- 9948831 TI - Copper isotope effect in Raman scattering on superconducting YBa2Cu3O7-x. PMID- 9948832 TI - Transport hysteresis of the oxide superconductor Y1Ba2Cu3O7-x in applied fields. PMID- 9948833 TI - Extension of Bean's model for high-Tc superconductors. PMID- 9948834 TI - Contact angle for two-dimensional Ising ferromagnets. PMID- 9948835 TI - Phase diagram of the half-filled 3D Hubbard model. PMID- 9948836 TI - Relation between half-width of neutron spectra and transport properties of fluids. PMID- 9948837 TI - Molecular dissociation in a two-dimensional model fluid: Evidence of a diffuse transition. PMID- 9948839 TI - Resonant activation of a Brownian particle out of a potential well: Remarks on some recent theoretical and experimental investigations. PMID- 9948838 TI - Cancellation of orbital and spin magnetism in UFe2. PMID- 9948840 TI - Erratum: "Self-consistent full-potential linearized-augmented-plane-wave local density electronic-structure studies of magnetism and superconductivity in Cl5 compounds ZrZn2 and ZrV2" PMID- 9948841 TI - Coexisting static magnetic order and superconductivity in CeCu2.1Si2 found by muon spin relaxation. PMID- 9948843 TI - Configurational dephasing in a weak-localization experiment. PMID- 9948842 TI - Direct determination of cobalt site preferences in Nd2Fe14B at infinite dilution. PMID- 9948844 TI - Low-temperature properties of superconducting materials on sublattice structures. PMID- 9948845 TI - Theoretical and experimental analysis of the superconducting transition effects on the Fermi-edge photoemission spectra. PMID- 9948847 TI - Determination of the critical exponents of superconducting Y-Ba-Cu-O. PMID- 9948846 TI - Exact diagonalization study of the frustrated Heisenberg model: A new disordered phase. PMID- 9948849 TI - Magnetoresistance and thermodynamic fluctuations in single-crystal YBa2Cu3Oy. PMID- 9948848 TI - Electronic structure of high-Tc Ba0.6K0.4BiO3 by x-ray photoelectron spectroscopy. PMID- 9948850 TI - Effects of interlayer interactions on the critical temperature of high-Tc compounds. PMID- 9948852 TI - Resonant excitation of an oxygen valence satellite in photoemission from high-Tc superconductors. PMID- 9948851 TI - Diffuse scattering in YBa2Cu PMID- 9948853 TI - Harmonic generation and flux quantization in granular superconductors. PMID- 9948854 TI - Possible high-Tc superconductivity in thin wires. PMID- 9948855 TI - Electronic band properties of Pb2Sr2YCu3O8. PMID- 9948856 TI - Magnetic relaxation in sintered Tl2Ca2Ba2Cu3Ox and YBa2Cu3O7-x superconductors. PMID- 9948857 TI - Angle-resolved photoemission spectra of single-crystal Bi2Sr2CaCu2Ox. PMID- 9948858 TI - Nonlinear electrodynamics and nonresonant microwave absorption in ceramic superconductors. PMID- 9948860 TI - Low-field flux-flow resistivity in Bi2.2Sr2Ca0.8Cu2BO8(+) delta. PMID- 9948859 TI - Oxygen partial-density-of-states change in the YBa2Cu3Ox compounds for x PMID- 9948861 TI - Synchronization of perturbed sine-Gordon soliton oscillators. PMID- 9948862 TI - Ferromagnetism in icosahedral Al-Mn-Si alloys. PMID- 9948863 TI - Approach to metallic behavior in metal-molten-salt solutions. PMID- 9948865 TI - Support for the Haldane conjecture: Gap for magnetic excitations in the quasi-one dimensional S=1 Heisenberg antiferromagnet AgVP2S6. PMID- 9948864 TI - Permeability versus conductivity for porous media with wide distribution of pore sizes. PMID- 9948866 TI - Kinetic equation for noninteracting electrons in the presence of strongly disordered magnetic impurities. PMID- 9948868 TI - CeRhIn: A new mixed-valent cerium compound. PMID- 9948867 TI - Enhanced magnetoresistance in layered magnetic structures with antiferromagnetic interlayer exchange. PMID- 9948870 TI - Magnetic anisotropy of Gd(0001)/W(110) monolayers. PMID- 9948869 TI - Dynamics on ultrametric spaces with random transfer rates. PMID- 9948871 TI - Electronic-structure calculation for metals by local optimization. PMID- 9948872 TI - Optical effects of methylated hydrazine intercalation in lead iodide. PMID- 9948873 TI - First-principles calculational methods for surface-vacancy formation energies, heats of segregation, and surface core-level shifts. PMID- 9948874 TI - Dynamical evaluation of Hartree-Fock exchange approximations. PMID- 9948875 TI - Corrections to the continuum approximation for the large polaron bound to a defect: The ground-state energy. PMID- 9948876 TI - Unoccupied electronic states of CuO: An oxygen 1s x-ray-absorption spectroscopy investigation. PMID- 9948877 TI - Mobility, interdiffusion, and tracer diffusion in lattice-gas models of two component alloys. PMID- 9948878 TI - Unoccupied surface states on Pd(111) observed in very-low-energy electron diffraction and inverse photoemission: Theoretical interpretation. PMID- 9948879 TI - Pd2: A dimer with two Kohn-Sham triplet ground states. PMID- 9948881 TI - Koshino-Taylor coefficient in electrical resistivity. PMID- 9948880 TI - Ground-state properties of fcc and bcc lanthanum. PMID- 9948883 TI - Dynamic correlations in electron liquids. II. Single-particle Green's functions. PMID- 9948882 TI - Dynamic correlations in electron liquids. I. General formalism. PMID- 9948884 TI - Total energies and bonding for crystallographic structures in titanium-carbon and tungsten-carbon systems. PMID- 9948885 TI - Theoretical analysis of orbital and correlation effects on the electronic absorption spectrum of the MnS4 center in zinc-blende crystals. PMID- 9948886 TI - Nonclassical particle dynamics in high magnetic fields. PMID- 9948887 TI - Electromigration and the local transport field in mesoscopic systems. PMID- 9948888 TI - Conjugate gradient minimization of the energy functional: A new method for electronic structure calculation. PMID- 9948889 TI - Ground state of the two-dimensional electron gas. PMID- 9948890 TI - Interplay of surface misfit and monatomic steps on crystal surfaces. III. Model for the {110} surface of an anisotropic bcc crystal. PMID- 9948891 TI - Direct determination of the self-diffusion mechanism in bcc beta -titanium. PMID- 9948892 TI - First-principles total-energy study of hydrogen adsorption on Be(0001). PMID- 9948893 TI - Lattice relaxation around substitutional defects in semiconductors. PMID- 9948895 TI - Influence of thin interfacial silicon oxide layers on the Schottky-barrier behavior of Ti on Si(100). PMID- 9948894 TI - Quantum Monte Carlo calculations of electron dynamics in dissipative solid-state systems using real-time path integrals. PMID- 9948896 TI - Schottky-barrier formation and atomic mixing at Au/ZnSe(100) and Co/ZnSe(100) interfaces with Co and Au interlayers. PMID- 9948898 TI - Intense small wave-vector scattering from voids in amorphous silicon: A theoretical simulation. PMID- 9948897 TI - Atom-resolved surface chemistry studied by scanning tunneling microscopy and spectroscopy. PMID- 9948899 TI - Dangling bonds in doped amorphous silicon: Equilibrium, relaxation, and transition energies. PMID- 9948901 TI - Transient photomodulation spectroscopy of nanocrystalline hydrogenated silicon. PMID- 9948902 TI - Fermi-level pinning and intrinsic surface states in cleaved GaP. PMID- 9948900 TI - Failure of the transitivity rule for (GaAs)3/(Ge)6 (110) and (AlAs)3/(Ge)6 (110) superlattice valence-band offsets. PMID- 9948903 TI - Correlated defect creation and dose-dependent radiation sensitivity in amorphous SiO2. PMID- 9948904 TI - Metastable conduction states in Mo2S3: Conductivity fluctuations. PMID- 9948905 TI - Quantum lattice fluctuations and optical properties of nondegenerate conjugated polymers. PMID- 9948906 TI - Electron correlations in the ground state of silicon. PMID- 9948907 TI - Band-edge states in short-period (GaAs)m/(AlAs)n superlattices. PMID- 9948909 TI - Inelastic electron scattering from the surfaces of semiconductor multilayers: Study of subband structure within the quantum well. PMID- 9948908 TI - Optical and electrical studies of interface traps in the Si/SiO2 system by modified junction space-charge techniques. PMID- 9948910 TI - Magnetocapacitance measurements of subband separation in an accumulation layer on n--type GaAs. PMID- 9948912 TI - Interaction of Si2H6 with a Si(111)-77 surface. PMID- 9948911 TI - Band-gap-dependent electron and hole transport in p-type HgTe-CdTe superlattices. PMID- 9948913 TI - Cooling of hot carriers in three- and two-dimensional Ga0.47In0.53As. PMID- 9948915 TI - Photopyroelectric spectroscopy of a-Si:H thin semiconducting films on quartz. PMID- 9948914 TI - High-resolution electron-energy-loss spectroscopy study of the uv-laser photodissociation of adsorbed Al2(CH3)6 on Si(100)21 and Si(111)77 surfaces. PMID- 9948916 TI - Lattice dynamics of Si calculated with a semiempirical approach. PMID- 9948917 TI - Electronic structure of CdTe(110) as studied by angle-resolved photoemission. PMID- 9948918 TI - Electron scattering by confined LO polar phonons in a quantum well. PMID- 9948920 TI - Local moments near the metal-insulator transition. PMID- 9948919 TI - Shallow positron traps in GaAs. PMID- 9948921 TI - Spatially resolved and energy-resolved defect kinetics in a-Si:H: A comprehensive study by phase-shift analysis of modulated photocurrents. PMID- 9948923 TI - Binding energy of ionized-donor-bound excitons in two-dimensional semiconductors. PMID- 9948922 TI - Electronic structures of polymeric CSe2, CSe, and C2Se. PMID- 9948925 TI - Dependence of transient resonant-tunneling characteristics on barrier thickness in AlAs/GaAs multiple-quantum-well structures. PMID- 9948924 TI - Correlations in phonon-transmission spectra in periodic and quasiperiodic superlattices. PMID- 9948926 TI - Thermal effects in the equilibrium structure and size distribution of small Si clusters. PMID- 9948927 TI - Vibron solitons. PMID- 9948928 TI - Theory of anisotropic donor states in quantum-well structures. PMID- 9948929 TI - Pseudo-Jahn-Teller effect for distortions involving oxygen and nitrogen impurities in silicon. PMID- 9948930 TI - Molecular-dynamics simulation of positive-ion and neutral halogen desorption following Na K-shell Auger cascades in the NaF crystal. PMID- 9948931 TI - Auger-induced valence processes in alkali halides following alkali core-hole creation. PMID- 9948932 TI - Thermal irreversibility in optically labeled low-temperature glasses. PMID- 9948933 TI - Methane adsorbed on graphite. IV. Multilayer growth at low temperature. PMID- 9948935 TI - Intercalant vibrations in a graphite intercalation compound observed by infrared reflectivity at a graphite-germanium interface. PMID- 9948934 TI - Hydrogen-bond melting in B-DNA copolymers in a mean-field self-consistent phonon approach. PMID- 9948936 TI - Light-induced oxidation and band-edge shifts in thermally evaporated films of germanium chalcogenide glasses. PMID- 9948938 TI - Localized-orbital approach to the electronic structure of anomalous muonium in diamond. PMID- 9948937 TI - Near-infrared photoluminescence bands in diamond. PMID- 9948939 TI - Vibrational properties of large-period crystals with finite-range interactions. PMID- 9948940 TI - Erratum: Metal-insulator transitions in doped silicon and germanium PMID- 9948941 TI - Quantum bound states in a classically unbound system of crossed wires. PMID- 9948943 TI - Conductance oscillations in two-dimensional Sharvin point contacts. PMID- 9948942 TI - Lack of mirror symmetry between x-ray absorption and emission edges of simple metals. PMID- 9948944 TI - Spin-polarized metastable-atom deexcitation spectroscopy: A new probe of the dynamics of metastable-atom-surface interactions. PMID- 9948945 TI - Electronic structure of alkali-metal overlayers on the semi-infinite jellium surface. PMID- 9948946 TI - Scanning tunneling microscopy of charge-density waves in NbSe3. PMID- 9948947 TI - Structural effects on the superconducting and magnetic behavior of aluminum-rich metallic glasses. PMID- 9948948 TI - Lattice-recoil effects in stimulated desorption from metal surfaces. PMID- 9948949 TI - Hall effect in quantum wires. PMID- 9948951 TI - Band-gap renormalization in quasi-two-dimensional systems induced by many-body electron-electron and electron-phonon interactions. PMID- 9948950 TI - Coupling of excitons with free electrons in light scattering from GaAs quantum wells. PMID- 9948952 TI - Core-level electron-energy-loss spectroscopy as a local probe for the electronic structure of the Co/Si(111) interface. PMID- 9948953 TI - Electronic structure of the single-domain Si(001)21-K surface. PMID- 9948954 TI - Radial distribution functions of amorphous silicon. PMID- 9948956 TI - Electronic transport through very short and narrow channels constricted in GaAs by highly resistive Ga-implanted regions. PMID- 9948955 TI - Excitonic transitions in strained-layer InxGa1-xAs/InP quantum wells. PMID- 9948957 TI - Unification of the properties of the EL2 defect in GaAs. PMID- 9948959 TI - Pressure dependence of the valence-band discontinuity in GaAs/AlAs and GaAs/AlxGa1-xAs quantum-well structures. PMID- 9948958 TI - Many-polaron interaction effects in two dimensions. PMID- 9948960 TI - Symmetry of conduction states for GaAs-AlAs type-II superlattices under uniaxial stress. PMID- 9948961 TI - Electron-paramagnetic-resonance measurements of Si-donor-related levels in AlxGa1 xAs. PMID- 9948962 TI - Phonon sideband of photoluminescence as a probe of exciton states in a quantum well. PMID- 9948963 TI - Excitons associated with subband dispersion in GaAs/AlxGa1-xAs superlattices. PMID- 9948964 TI - Modeling solid-state chemistry: Interatomic potentials for multicomponent systems. PMID- 9948965 TI - Surface rotational phonon and its role in the reconstruction of cleavage surfaces of tetrahedrally coordinated compound semiconductors. PMID- 9948966 TI - Band bending and the apparent barrier height in scanning tunneling microscopy. PMID- 9948967 TI - Metallic properties of the Ge(001) surface. PMID- 9948968 TI - Photoemission study of the growth and modification of the Al/Ta(110) interface. PMID- 9948969 TI - Self-consistent calculation of the surface electronic structure of the (1 x 2) reconstructed Au(110) surface. PMID- 9948971 TI - Vibrational properties of epitaxial films on metals. I. fcc Cu on the Ni(001) surface. PMID- 9948970 TI - Hydrogen ordering in alpha -LuDx investigated by diffuse neutron scattering. PMID- 9948972 TI - Vibrational properties of epitaxial films on metals. II. fcc Ni on the Cu(001) surface. PMID- 9948974 TI - Spherical-wave corrections in photoelectron diffraction. PMID- 9948973 TI - Theoretical study of hydrogen adsorption on Ru(0001): Possible surface and subsurface occupation sites. PMID- 9948975 TI - Band-narrowing effects in URh3Bx. PMID- 9948977 TI - Random-deposition models for thin-film epitaxial growth. PMID- 9948976 TI - Electronic structure, cohesive, and magnetic properties of the actinide-iridium Laves phases. PMID- 9948978 TI - Inelastic neutron scattering of amorphous Ni0.95Tb0.05. PMID- 9948979 TI - Effective dielectric constant of dilute suspensions of spheres. PMID- 9948980 TI - Dephasing effects in a two-dimensional magnetic-breakdown linked-orbit network: Magnesium. PMID- 9948981 TI - Molecular orbital theory for chemisorption and physisorption: The case of He on metals. PMID- 9948982 TI - Electromagnetic modes of corrugated thin films and surfaces with a transition layer. II. Minigaps. PMID- 9948984 TI - Medium-energy ion scattering study of the initial stage of oxidation of Fe(001). PMID- 9948983 TI - Polarons and soliton pairs (bipolarons) in halogen-doped quasi-one-dimensional mixed-valence platinum complexes. PMID- 9948985 TI - Structural, electronic, and magnetic properties of a Ni monolayer on Ag(001): Ni adsorption versus Ag surface segregation. PMID- 9948987 TI - Dynamical diffraction of x rays at grazing angle. PMID- 9948986 TI - Brillouin scattering in incommensurate Rb2ZnBr PMID- 9948988 TI - Compound formation and superconductivity in Au-Si: X-ray absorption measurements on ion-beam-mixed Au-Si films. PMID- 9948990 TI - Nonlinear lattice relaxation of photogenerated charge-transfer excitation in halogen-bridged mixed-valence metal complexes. I. Soliton and self-trapped exciton. PMID- 9948989 TI - Optical properties of Mo. PMID- 9948991 TI - Nonlinear lattice relaxation of photogenerated charge-transfer excitation in halogen-bridged mixed-valence metal complexes. II. Polaron channel. PMID- 9948993 TI - Measurement of the effect of uniaxial stress on the spectrum of CaF2:Pr3+:D- using spectral hole burning. PMID- 9948992 TI - Phase stabilities of the Co3Ti and Ni3V alloys. PMID- 9948994 TI - Electromagnetic-resonance-induced optical response of a thin nonlinear dielectric film. PMID- 9948996 TI - Local modes in Rb1-cKc alloys using microscopic force constants. PMID- 9948995 TI - Structure and melting of lead overlayers on Cu(100) studied with thermal-energy atom scattering. PMID- 9948997 TI - Electronic theory for phase stability of nine AB binary alloys, with A=Ni, Pd, or Pt and B=Cu, Ag, or Au. PMID- 9948998 TI - Anisotropic magnetoconductivity of a three-dimensional disordered electron gas. PMID- 9948999 TI - Photon localization in a disordered multilayered system. PMID- 9949000 TI - Structure of the Cs-induced (1 x 3) reconstruction of Au(110). PMID- 9949001 TI - Finite-element method for electronic structure. PMID- 9949003 TI - Three-dimensional Patterson function for the Al6CuLi3 quasicrystal. PMID- 9949002 TI - Cantor spectra and scaling of gap widths in deterministic aperiodic systems. PMID- 9949004 TI - Raman scattering in (GaP)1/(InP)1 strained-layer superlattices. PMID- 9949005 TI - Temperature effects on the band-gap energy in p-type III-V semiconductors. PMID- 9949006 TI - Electronic Raman scattering in Cd1-xCoxSe. PMID- 9949008 TI - Collective and vibrational excitations on the n-doped GaAs(110) surface. PMID- 9949007 TI - Conductivity as a function of conjugation length: Theory and experiment for conducting polymer complexes. PMID- 9949009 TI - Shell-model interpolation of frozen phonons in cubic silicon carbide. PMID- 9949010 TI - Resonant Raman scattering from diluted polyacetylene chains. PMID- 9949011 TI - LO-phonon confinement and polaron effect in a quantum well. PMID- 9949012 TI - Intrinsic exciton states in indirect-band-gap GaAsxP1-x: Composition dependence and effects of impurities. PMID- 9949013 TI - Semiconductor photoelastic constants measured by light scattering in superlattices. PMID- 9949014 TI - Quantum-mechanical resonant tunneling in the presence of a boson field. PMID- 9949016 TI - Electron transport in a disordered semiconductor superlattice. PMID- 9949015 TI - Indium-doped GaAs: Investigation of deep traps. PMID- 9949017 TI - Fractional quantum Hall effect in a two-dimensional hole gas. PMID- 9949018 TI - Phase transitions in polypyrrole and polythiophene conducting polymers demonstrated by magnetic susceptibility measurements. PMID- 9949019 TI - Anisotropy of the electronic structures of the GaP(110) surface: A high resolution electron-energy-loss spectroscopy study. PMID- 9949021 TI - Effect of relaxation of the second-nearest neighbors on the thermodynamic properties of semiconducting alloys: Application to GaAsySb1-y. PMID- 9949020 TI - Surface segregation in pseudobinary alloys. PMID- 9949022 TI - Quantum theory of plasmons in lateral multiwire superlattices in the presence of subband quantization: Intersubband plasmons. PMID- 9949024 TI - Antisites, antistructures, and bond-switching reactions in layered chalcogenides. PMID- 9949023 TI - Photoemission and inverse photoemission of transition-metal silicides. PMID- 9949026 TI - Structural correlations and phonon density of states in GeSe2: A molecular dynamics study of molten and amorphous states. PMID- 9949025 TI - Phonons in GaAs/AlAs superlattices. PMID- 9949027 TI - Photon-energy-sensitive Si L2,3VV Auger satellite. PMID- 9949028 TI - Defects at the Si(111)/SiO2 interface investigated with low-energy electron diffraction. PMID- 9949029 TI - k PMID- 9949030 TI - New interpretation of activation enthalpies for electrical conductivity and nuclear spin relaxation in glassy ionic conductors. PMID- 9949031 TI - Properties of laser-induced gratings in Eu-doped glasses. PMID- 9949032 TI - Alkali-metal oxides. I. Molecular and crystal-field effects in photoemission. PMID- 9949033 TI - Alkali-metal oxides. II. Unoccupied and excited states. PMID- 9949034 TI - Raman and infrared studies of the CN- stretching-mode anharmonicity and its relation to phase transitions in pure alkali cyanides. PMID- 9949036 TI - Spin-resolved photoemission from the (100) face of tantalum carbide. PMID- 9949035 TI - Molecular-dynamics study of the temperature-dependent two-dimensional Rb liquid in graphite. PMID- 9949037 TI - Electron emission due to positronium annihilation in solid Ar, Kr, and Xe. PMID- 9949038 TI - Multiple-scattering approach to the M-edge x-ray-absorption spectra of UO2 and UCl4. PMID- 9949039 TI - Absolute thermoelectric power in ferromagnetic amorphous FexNi80-xB20 alloys. PMID- 9949040 TI - 1H NMR study of residual HNO3-intercalated graphite. PMID- 9949041 TI - Electronic properties of CoO(100) surfaces: Defects and chemisorption. PMID- 9949042 TI - Correlation between the activation enthalpy and Kohlrausch exponent for ionic conductivity in alkali aluminogermanate glasses. PMID- 9949043 TI - Neutron inelastic scattering from fumed silica. PMID- 9949044 TI - Neutron powder diffraction study in the mixed molecular system (NaCN)1-x(KCN)x. PMID- 9949045 TI - Photoemission studies of the interaction of Li and solid molecular oxygen. PMID- 9949047 TI - Anisotropic introduction of intrinsic defects in GaAs monitored by Raman scattering. PMID- 9949046 TI - Photoemission study of the bulk magnetic phase transition in Cr. PMID- 9949048 TI - Current bistability in double-barrier resonant-tunneling devices. PMID- 9949049 TI - Two-stream instability in two-dimensional degenerate systems. PMID- 9949050 TI - Hot-carrier quantum distribution function in crossed electric and magnetic fields. PMID- 9949051 TI - Theory of time-resolved luminescence of bound excitons in semiconductor alloys. PMID- 9949052 TI - Raman coupling-parameter variation in amorphous silicon. PMID- 9949053 TI - Surface core-level binding-energy shifts for the cleaved GaP(110) surface. PMID- 9949054 TI - Suppression of the Aharonov-Bohm effect in the quantized Hall regime. PMID- 9949056 TI - Phase stability of ZrO2-Al PMID- 9949055 TI - Heat capacity of magnetite in the range 0.3 to 10 K. PMID- 9949058 TI - Highly anisotropic metals in magnetic fields: Localization and critical point. PMID- 9949057 TI - Transition from commensurate to incommensurate xenon rafts on platinum (111) observed with molecular dynamics. PMID- 9949059 TI - Scanning tunneling microscopy and the electronic and structural properties of intercalated graphite surfaces. PMID- 9949060 TI - Electron resonances in alkali-metal overlayers on metals. PMID- 9949061 TI - Electron paramagnetic resonance identification of the SbGa heteroantisite defect in GaAs:Sb. PMID- 9949062 TI - Excitonic lifetimes in thin InxGa1-xAs/InP quantum wells. PMID- 9949064 TI - Electron-hole liquids and band-gap renormalization in short-period semiconductor superlattices. PMID- 9949063 TI - Quantum Hall effect in wide parabolic GaAs/AlxGa1-xAs wells. PMID- 9949065 TI - Cyclotron resonance in donor and acceptor delta -doped AlxGa1-xAs/GaAs heterostructures. PMID- 9949067 TI - Transport of the photoexcited electron-hole plasma in GaAs quantum wells. PMID- 9949066 TI - Negative differential conductance in GaAs/AlAs superlattices. PMID- 9949068 TI - Negative spin-orbit bowing in semiconductor alloys. PMID- 9949070 TI - Spin-orbit splitting of the valence bands in silicon determined by means of high resolution photoconductive spectroscopy. PMID- 9949069 TI - Empirical relation between gate voltage and electrostatic potential in the one dimensional electron gas of a split-gate device. PMID- 9949071 TI - Erratum: Liquid-solid transition and the fractional quantum-Hall effect PMID- 9949072 TI - Erratum: Precision determination of small energy shifts in Mossbauer spectroscopy PMID- 9949073 TI - Erratum: Density of states for interacting tunneling units in the absence of long range order PMID- 9949075 TI - Erratum: Spin-orbit and paramagnon effects on magnetoconductance and tunneling PMID- 9949074 TI - Erratum: Electron mobility in modulation-doped heterostructures PMID- 9949076 TI - Erratum: Magnetoresistance maximum at the metal-insulator transition of granular aluminum PMID- 9949077 TI - Erratum: Connection between the formation volume and formation Gibbs energy in noble-gas solids PMID- 9949078 TI - Erratum: Reference-plane position for atom-surface van der Waals interactions PMID- 9949080 TI - Erratum: Hybridization and screening effects in the Mg KL1V Auger spectra of Mg Ni, Mg-Cu, Mg-Zn, Mg-Pd, Mg-Ag, and Mg-Al alloys PMID- 9949079 TI - Erratum: Role of elastic and electronic interactions in trapping of hydrogen by impurities in transition metals PMID- 9949081 TI - Erratum: Chain model of Si (111)2 x 1 surface: Optical properties and surface state excitons PMID- 9949082 TI - Erratum: Surface phonon dispersion of c(2 x 2) S on Ni(100) PMID- 9949083 TI - Erratum: Exciton transfer at low temperature in GaxIn1-xP:N and GaAs1-xPx:N PMID- 9949084 TI - Erratum: Screening of polar interaction in quasi-two-dimensional semiconductor microstructures PMID- 9949086 TI - Erratum: Analytic continuation and appearance of a new phase for n<1 in n component ( phi2)2 field theory PMID- 9949085 TI - Erratum: Temperature dependence of spin dynamics in the impurity-doped one dimensional antiferromagnetic (CH3)4NM2+C13:Cd2+ PMID- 9949087 TI - Erratum: Band offsets from two special GaAs-AlxGal-x As quantum-well structures PMID- 9949088 TI - Erratum: Incompressible states of the fractionally quantized Hall effect in the presence of impurities: A finite-size study PMID- 9949090 TI - Erratum: Eigenstates of Wannier exccitons near a semiconductor surface PMID- 9949089 TI - Erratum: Fermi surface, effective masses, and Dingle temperatures of ZrTe5 as derived from the Shubnikov-de Haas effect PMID- 9949091 TI - Erratum: Theoretical study of the surface energy and surface relaxation of the W(001) surface PMID- 9949092 TI - Erratum: Indirect band gap of coherently strained GexSil-x bulk alloys on <001> silicon substrates PMID- 9949093 TI - Erratum: Diffuse interface model of diffusion-limited crystal growth PMID- 9949094 TI - Erratum: Second-order quadrupolar echo PMID- 9949095 TI - Erratum: Analysis of quasielastic light scattering in LiNbO3 near TC PMID- 9949096 TI - Erratum: Inverse dielectric function of a periodic superlattice PMID- 9949097 TI - Erratum: Quasiclassical approximation to final-state effects in the scattering of neutrons from a hard-core fluid PMID- 9949098 TI - Erratum: Wetting of a glass substrate by a binary liquid mixture PMID- 9949100 TI - Erratum: Density-functional approximation for the correlation energy of the inhomogeneous electron gas PMID- 9949099 TI - Erratum: Electronic response function of coupled chains of finite radius PMID- 9949102 TI - Erratum: Electron-phonon interactions and charge-density-wave formations in strong magnetic fields PMID- 9949101 TI - Erratum: Photoemission study of the hydrogenation of the intermetallic compounds YFe3 and YFe2 PMID- 9949103 TI - Erratum: Electrical study of Schottky barriers on atomically clean GaAs(110) surfaces PMID- 9949104 TI - Erratum: Numerical simulations of modulated systems PMID- 9949105 TI - Erratum: Criterion for the observability of macroscopic quantum coherence PMID- 9949106 TI - Erratum: Effect of adsorbate binding sites on surface-reconstruction phase diagrams: O/W(001) and H/W(001) PMID- 9949107 TI - Erratum: Dipole-dipole interactions and two-dimensional magnetism PMID- 9949108 TI - Erratum: Optical nonlinearity, band-structure parameters, and refractive indices of some mixed chalcopyrite crystals PMID- 9949110 TI - Erratum: Electronic and vibrational spectra of two-dimensional quasicrystals PMID- 9949109 TI - Erratum: Electron-phonon interactions and charge-density-wave formations in strong magnetic fields PMID- 9949111 TI - Erratum: Correlation functions of the antiferromagnetic Heisenberg model using a modified Lanczos method PMID- 9949112 TI - Erratum: Electron correlation and the band gap in ionic crystals PMID- 9949113 TI - Erratum: Quantum-mechanical theory of stress and force PMID- 9949114 TI - Erratum: Relaxation of the rocksalt (001) surface: Alkali halides, MgO, and PbS PMID- 9949115 TI - Erratum: Influence of the electron-phonon interaction on the Aharonov-Bohm effect PMID- 9949116 TI - Erratum: Localization by electric fields in one-dimensional tight-binding systems PMID- 9949117 TI - Erratum: Oxide traps in Si-SiO2 structures characterized by tunnel emission with deep-level transient spectroscopy PMID- 9949118 TI - Erratum: Electrical resistivity of icosahedral Mg-Al-Zn alloys PMID- 9949119 TI - Erratum: Conduction-band-edge charge densities in elemental and compound semiconductors PMID- 9949120 TI - Erratum: Localization, superconducting fluctuations, and superconductivity in thin films and narrow wires of aluminum PMID- 9949121 TI - Erratum: Correlation effects in S=12 random-exchange Heisenberg antiferromagnetic chains PMID- 9949122 TI - Erratum: Green's-function calculations of 5s-5p x-ray photoemission spectra of Ra (Z=88) and Th (Z=90) PMID- 9949123 TI - Erratum: Embedded-atom-method functions for the fcc metals Cu, Ag, Au, Ni, Pd, Pt, and their alloys PMID- 9949125 TI - Erratum: Density-functional approach to second-harmonic generation at metal surfaces PMID- 9949124 TI - Erratum: Influence of doping on the etching of Si(111) PMID- 9949127 TI - Erratum: Photoemission from supported metal clusters: The problem of the support PMID- 9949126 TI - Erratum: Surface plasmons on n-type semiconductors: Influence of depletion and accumulation layers PMID- 9949128 TI - Erratum: Comment on "Solvated polaron in an ionic lattice" PMID- 9949129 TI - Erratum: Superconductivity from nonphonon interactions PMID- 9949130 TI - Erratum: Far-infrared spectroscopy of RBa2Cu3Ox with variations in R and x PMID- 9949131 TI - Erratum: X-ray absorption measurements on high-Tc superconductors: Cu-valence and cation-bond-length effects PMID- 9949133 TI - Erratum: Long-range order in AlxGa1-xAs PMID- 9949132 TI - Erratum: Photon-stimulated desorption of neutral O2 from YBa2Cu2O7-x by core level excitation PMID- 9949134 TI - Erratum: Universality relationships in condensed matter: Bulk modulus and sound velocity PMID- 9949135 TI - Erratum: Stopping of Havar, nickel, Kapton, and Mylar for 5-19-MeV 16O ions PMID- 9949136 TI - Erratum: Nitrogen-ion energy loss in Havar, nickel, Kapton, and Mylar foils PMID- 9949137 TI - Erratum: Surface electromagnetic modes in metal spheres PMID- 9949138 TI - Erratum: Light scattering in strongly scattering media: Multiple scattering and weak localization PMID- 9949139 TI - Erratum: Hyperuniversality and the renormalization group for finite systems PMID- 9949140 TI - Erratum: Temperature dependence of spin dynamics in the impurity-doped quasi-two dimensional antiferromagnet C2H5(NH3)2MnCl4 2+:Cu2+ PMID- 9949141 TI - Erratum: Vortex lattice structures in uniaxial superconductors PMID- 9949143 TI - Erratum: Resonant Raman studies of confined LO modes and interface modes in a small-period GaAs/AlAs superlattice PMID- 9949142 TI - Erratum: Self-consistent-field X alpha scattered-wave calculation of the electronic structure of arsenic chalcogenide molecules PMID- 9949144 TI - Erratum: Temperature dependence and anharmonicity of the Debye-Waller factor in sodium metal using Mossbauer gamma -ray diffraction PMID- 9949146 TI - Erratum: Analytic calculation of ground-state properties of correlated fermions with the Gutzwiller wave function PMID- 9949145 TI - Erratum: Effective-medium theory of long-wavelength spin waves in magnetic superlattices PMID- 9949147 TI - Erratum: Theory of interlayer spacing in ternary graphite intercalation compounds PMID- 9949149 TI - Erratum: Electron-diffraction study of SbCl5-intercalated graphite PMID- 9949148 TI - Erratum: Diffusion path and Haven's ratio of mobile ions in alpha -Ag2Te PMID- 9949151 TI - Erratum: Current- and spin-density-functional theory for inhomogeneous electronic systems in strong magnetic fields PMID- 9949150 TI - Erratum: "Theoretical explanation of zero-field splitting and its pressure, and temperature dependence in NiSIF6 PMID- 9949152 TI - Sentinel-lymph-node biopsy. PMID- 9949153 TI - Sentinel-lymph-node biopsy. PMID- 9949154 TI - Hepatitis viruses and hematopoietic cell transplantation: A guide to patient and donor management. PMID- 9949155 TI - Interferon-gamma upregulates CCR5 expression in cord and adult blood mononuclear phagocytes. AB - The C-C chemokine receptors CCR5 and CCR3 are fusion coreceptors for human immunodeficiency virus (HIV) entry into macrophages. The regulation of their expression influences infectivity by HIV. We report here that interferon-gamma (IFN-gamma) a cytokine that has bidirectional effects on HIV infection of macrophages, significantly upregulated CCR5 and CCR3 cell surface expression in human mononuclear phagocytes isolated from placental cord blood and adult peripheral blood. Monocytes treated with IFN-gamma showed increased chemotaxis to the CCR5 ligands macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP 1beta, confirming the functional relevance of IFN-gamma-induced CCR5 expression. However, IFN-gamma suppressed HIV entry into macrophages. Interestingly, we demonstrated that IFN-gamma inhibited cell surface expression of CD4, the major receptor for HIV. This finding may explain the suppressive effect of IFN-gamma on HIV entry into macrophages, despite its enhancing effect on the expression of CCR5 and CCR3 by these cells. In addition, IFN-gamma-induced secretion of C-C chemokines (RANTES, MIP-1alpha, and MIP-1beta) by mononuclear phagocytes may also suppress HIV entry into macrophages. These data provide further evidence for cytokine-mediated regulation of CCR5 expression and are consistent with a novel paradigm in which cytokines regulate HIV infection and leukocyte migration by reciprocal and opposing effects on the expression of CD4 and chemokine receptors. PMID- 9949156 TI - Coreceptor/chemokine receptor expression on human hematopoietic cells: biological implications for human immunodeficiency virus-type 1 infection. AB - The recent discovery of chemokine receptors as coreceptors for human immunodeficiency virus-type 1 (HIV-1) entry offers new avenues for investigating the pathogenesis of acquired immunodeficiency syndrome (AIDS)-related cytopenias. To this end, we sought to (1) phenotype human hematopoietic cells for CD4 and the HIV-1 coreceptors CXCR4, CCR5, CCR3, and CCR2b; (2) correlate CD4 and chemokine receptor expression with their susceptibility to HIV-1 infection; and (3) examine any potential interplay between inflammatory cytokines released during HIV-1 infection and regulation of chemokine receptor expression. Fluorescence-activated cell sorting (FACS) analysis of bone marrow mononuclear cells (BMMNC), cells derived from serum-free expanded hematopoietic lineages (colony-forming unit granulocyte-macrophage [CFU-GM], colony-forming unit-megakaryocyte [CFU-Meg], and burst-forming unit-erythroid [BFU-E]), and CD34(+) cells showed differential expression of chemokine receptors and CD4 with some lineage specificity. Significantly, FACS-sorted CXCR4(+)/CD34(+) cells had the same clonogeneic potential as CXCR4(-)/CD34(+) cells. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of FACS-sorted human candidate stem cells (HSC; CD34(+), c-kit+, Rho123(low)) showed the presence of CXCR4 mRNA but not CD4 mRNA. Infection studies with HIV-1 Env-pseudotyped luciferase reporter viruses indicated that X4 Env (CXCR4-using) pseudotypes infected megakaryocytic cells, whereas R5 Env (CCR5-using) pseudotypes did not. Similarly, R5 but not X4 Env pseudotyped viruses infected granulocyte-macrophage cells in a CD4/CCR5-dependent manner. Erythroid cells were resistant to R5 or X4 viral infection. Finally, we found that gamma-interferon treatment upregulated CXCR4 expression on primary hematopoietic cells. In summary, the delineation of chemokine receptor expression on primary hematopoietic cells is a first step towards dissecting the chemokine chemokine receptor axes that may play a role in hematopoietic cell proliferation and homing. Furthermore, susceptibility of hematopoietic cells to HIV-1 infection is likely to be more complicated than the mere physical presence of CD4 and the cognate chemokine receptor. Lastly, our results suggest a potential interplay between gamma-interferon secretion and CXCR4 expression. PMID- 9949157 TI - Endogenous interleukin-8 (IL-8) surge in granulocyte colony-stimulating factor induced peripheral blood stem cell mobilization. AB - The relationship between stem cell mobilization with granulocyte colony stimulating factor (G-CSF) and the endogenous production of interleukin-8 (IL-8), macrophage inflammatory protein-1alpha (MIP-1alpha), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) was studied in normal donors for allogeneic peripheral blood stem cell (PBSC) transplantation. G-CSF was administered to 20 normal donors at a dose of 10 microg/kg/d for 5 days with aphereses on days 5 and 6 of G-CSF treatment. Cytokine serum levels were measured using an enzyme-linked immunosorbent assay (ELISA) before and during G-CSF treatment. Before treatment, the average level of IL-8 was 7.1 pg/mL, increasing to 207.0 pg/mL on day 5 and 189.1 pg/mL on day 6. Serum IL-8 levels correlated CD34(+) cell numbers (P =.0151 and P =.0005 on days 5 and 6, respectively) and colony-forming unit-granulocyte-macrophage (CFU-GM) numbers (P =.0019 and P =.0010 on days 5 and 6, respectively). Furthermore, preapheresis serum IL-8 levels correlated with the yield of CD34(+) cells (P =.0027). In contrast, before treatment, the average levels of MIP-1alpha, TNF-alpha, and IFN-gamma were 70.1, 4.03, and 3.84 pg/mL, respectively, and no significant changes in the levels of these cytokines were observed during G-CSF treatment. These studies suggest that IL-8 production may be critical to G-CSF-induced stem cell mobilization, although the underlying mechanism could not be clarified. PMID- 9949158 TI - Bone marrow transplantation in adult thalassemic patients. AB - One hundred seven adult patients with thalassemia aged from 17 through 35 years and transplanted from HLA-identical siblings between November 1988 and September 1996 were evaluated on December 31, 1997. The outcome experience of 20 consecutive patients transplanted between November 13, 1988 and January 10, 1991 and reported in September 1992 is updated after 5 additional years. The experience on 87 patients transplanted between May 1991 and September 1996 is described and evaluated as of the end of December 1997. Of 107 patients, 69 survive between 1.5 and 9 years after transplantation. Sixty-six of these patients do not have thalassemia and are identified as ex-thalassemic after bone marrow transplantation. The youngest survivor is 20 years old, 6 are older than 30 years, and the oldest is 37 years of age. Patients with chronic active hepatitis at the time of transplant were significantly more likely to die than patients without (P =.05; relative risk, 2.05). Marrow transplantation is a valid treatment option for older patients with thalassemia who have suitable donors and show deterioration with conventional therapy. PMID- 9949159 TI - Expression of alpha4-integrin defines the earliest precursor of hematopoietic cell lineage diverged from endothelial cells. AB - Embryonic stem cells can differentiate in vitro into hematopoietic cells through two intermediate stages; the first being FLK1(+) E-cadherin- proximal lateral mesoderm and the second being CD45(-) VE-cadherin+ endothelial cells. To further dissect the CD45(-) VE-cadherin+ cells, we have examined distribution of alpha4 integrin on this cell population, because alpha4-integrin is the molecule expressed on hematopoietic stem cells. During culture of FLK1(+) E-cadherin- cells, CD45(-) VE-cadherin+ alpha4-integrin- cells differentiate first, followed by alpha4-integrin+ cells appearing in both CD45(-) VE-cadherin+ and CD45(-) VE cadherin- cell populations. In the CD45(-) VE-cadherin+ cell population, alpha4 integrin+ subset but not alpha4-integrin- subset had the potential to differentiate to hematopoietic lineage cells, whereas endothelial cell progenitors were present in both subsets. The CD45(-) VE-cadherin- alpha4 integrin+ cells also showed hematopoietic potential. Reverse transcription polymerase chain reaction analyses showed that differential expression of the Gata2 and Myb genes correlated with the potential of the alpha4-integrin+ cells to give rise to hematopoietic cell differentiation. Hematopoietic CD45(-) VE cadherin+ alpha4-integrin+ cells were also present in the yolk sac and embryonic body proper of 9.5 day postcoitum mouse embryos. Our results suggest that the expression of alpha4-integrin is a marker of the earliest precursor of hematopoietic cell lineage that was diverged from endothelial progenitors. PMID- 9949160 TI - Lineage-restricted expression of protein kinase C isoforms in hematopoiesis. AB - The pattern of expression of several protein kinase C (PKC) isoforms (alpha, betaI, delta, epsilon, eta, and zeta) during the course of hematopoietic development was investigated using primary human CD34(+) hematopoietic cells and stable cell lines subcloned from the growth factor-dependent 32D murine hematopoietic cell line. Each 32D cell clone shows the phenotype and growth factor dependence characteristics of the corresponding hematopoietic lineage. Clear-cut differences were noticed between erythroid and nonerythroid lineages. (1) The functional inhibition of PKC-epsilon in primary human CD34(+) hematopoietic cells resulted in a twofold increase in the number of erythroid colonies. (2) Erythroid 32D Epo1 cells showed a lower level of bulk PKC catalytic activity, lacked the expression of epsilon and eta PKC isoforms, and showed a weak or absent upregulation of the remaining isoforms, except betaI, upon readdition of Epo to growth factor-starved cells. (3) 32D, 32D GM1, and 32D G1 cell lines with mast cell, granulo-macrophagic, and granulocytic phenotype, respectively, expressed all the PKC isoforms investigated, but showed distinct responses to growth factor readdition. (4) 32D Epo 1.1, a clone selected for interleukin-3 (IL-3) responsiveness from 32D Epo1, expressed the epsilon isoform only when cultured with IL-3. On the other hand, when cultured in Epo, 32D Epo1.1 cells lacked the expression of both epsilon and eta PKC isoforms, similarly to 32D Epo1. (5) All 32D cell lines expressed the mRNA for PKC-epsilon, indicating that the downmodulation of the epsilon isoform occurred at a posttranscriptional level. In conclusion, the PKC isoform expression during hematopoiesis appears to be lineage-specific and, at least partially, related to the growth factor response. PMID- 9949161 TI - Inhibitory effect of the transcription factor encoded by the mi mutant allele in cultured mast cells of mice. AB - The mi locus of mice encodes a transcription factor of the basic-helix-loop-helix leucine zipper protein family (MITF). The MITF encoded by the mutant mi allele (mi-MITF) deletes 1 of 4 consecutive arginines in the basic domain. The mice of mi/mi genotype express mi-MITF, whereas the mice of tg/tg genotype have a transgene at the 5' flanking region of the mi gene and do not express any MITF. To investigate the function of mi-MITF in cultured mast cells (CMCs), we took two approaches. First, mRNA obtained from mi/mi CMCs or tg/tg CMCs was subtracted from complementary (c) DNA library of normal (+/+) CMCs, and the (+/+-mi/mi) and (+/+-tg/tg) subtraction libraries were obtained. When the number of clones that hybridized more efficiently with +/+ CMC cDNA probe than with mi/mi or tg/tg CMC cDNA probe was compared using Southern analysis, the number was larger in the (+/+-mi/mi) library than in the (+/+-tg/tg) library. Second, we compared mRNA expression of six genes between mi/mi and tg/tg CMCs by Northern analysis. The transcription of three genes encoding mouse mast cell proteases was impaired in both mi/mi and tg/tg CMCs. On the other hand, the transcription of three genes encoding c-kit receptor, tryptophan hydroxylase, and granzyme B was markedly reduced in mi/mi CMCs, but the reduction was significantly smaller in tg/tg CMCs. These results indicated the inhibitory effect of mi-MITF on the transactivation of particular genes in CMCs. PMID- 9949162 TI - The nuclear topography of ABL, BCR, PML, and RARalpha genes: evidence for gene proximity in specific phases of the cell cycle and stages of hematopoietic differentiation. AB - The mechanisms whereby chromosomal translocations are consistently associated with specific tumor types are largely unknown. A generally accepted hypothesis is that the physical proximity of the involved chromosomal regions may be one important factor in the genesis of these phenomena. Accordingly, a likely possibility is that such a proximity may occur in a cell-lineage and cell differentiation stage-specific manner. In this work, we have addressed this issue using as models the ABL and BCR genes of t(9;22) and the PML and RARalpha genes of t(15;17). By using in situ hybridization and confocal microscopy, we have measured the distances between these two pairs of genes in three-dimensionally preserved hematopoietic cells belonging to different cell lineages, at various stages of differentiation, and at various stages of the cell cycle, with the following results. (1) Intergenic distances vary periodically during the cell cycle and a significant association of ABL with BCR and of PML with RARalpha is seen at the transition between S and G2, which persists during G2 and prophase (such a behavior is not observed for distances between ABL or PML and the beta globin genes, used as a control). (2) The proportion of cells in which PML and RARalpha or ABL and BCR are closely associated is higher in hematopoietic precursors than in B-lymphoid cells (whereas the distances between ABL or PML and the beta-globin genes are not affected by cell type). (3) When intergenic distances in unstimulated bone marrow CD34(+) cells were compared with those in CD34(+) cells treated with interleukin-3 (IL-3), a trend towards a higher proximity of the ABL and BCR genes in the former and of the PML and RARalpha genes in the latter is observed. (4) Analysis of B-lymphoid cells during mitosis shows that intergenic distances at metaphase are strongly influenced by physical constraints imposed by the chromosomal location of the gene, by the size of the respective chromosome, and by the geometry of the metaphase plate. These findings suggest that intrinsic spatial dynamics, established early in hematopoiesis and perpetuated differentially in distinct cell lineages, may facilitate the collision of individual genes and thus reciprocal recombination between them at subsequent stages of hematopoietic differentiation. PMID- 9949163 TI - Transforming growth factor-beta1 polarizes murine hematopoietic progenitor cells to generate Langerhans cell-like dendritic cells through a monocyte/macrophage differentiation pathway. AB - We have recently demonstrated that CD11b-/dullCD11c+ and CD11b+hiCD11c+ dendritic cell (DC) precursor subsets represent two distinct DC differentiation pathways from murine bone marrow lineage-phenotype negative (Lin-)c-kit+ hematopoietic progenitor cells (HPCs) stimulated with granulocyte-macrophage colony-stimulating factor (GM-CSF) + stem cell factor (SCF) + tumor necrosis factor alpha (TNFalpha). We show here that transforming growth factor-beta1 (TGF-beta1) significantly inhibits the generation of these CD11b-/dullCD11c+ and CD11b+hiCD11c+ DC precursors. Phenotypically, this inhibitory effect was accompanied by markedly suppressed expression of Ia and CD86 antigens as well as major histocompatibility complex (MHC) class II transactivator (CIITA) and CC chemokine receptor 7 (CCR7) mRNAs in Lin-c-kit+ HPC cultures stimulated with GM CSF + SCF + TNFalpha at day 6. TGF-beta1 could also suppress mature DC differentiation from CD11b+hiCD11c+ DC precursors, but not the differentiation from CD11b-/dullCD11c+ DC precursors. In the absence of TNFalpha, TGF-beta1 markedly suppressed the expression of CIITA and CCR7 mRNAs in GM-CSF + SCF stimulated Lin-c-kit+ HPCs at either day 6 or day 12 and induced the differentiation solely into monocytes/macrophages as evident in morphology, active phagocytic, and endocytic activities. These cells expressed high levels of F4/80 and E-cadherin antigens, but low or undetectable levels of Ia, CD86, and CD40 molecules. However, upon the stimulation with TNFalpha + GM-CSF, these cells could further differentiate into mature DCs expressing high levels of Ia and E cadherin, characteristics for Langerhans cells (LCs), and gained the capacity of enhancing allogenic MLR. Taken together, all of these findings suggest that TGF beta1 polarizes murine HPCs to generate LC-like DCs through a monocyte/macrophage differentiation pathway. PMID- 9949164 TI - Cooperative activity of alpha4beta1 and alpha4beta7 integrins in mediating human B-cell lymphoma adhesion and chemotaxis on fibronectin through recognition of multiple synergizing binding sites within the central cell-binding domain. AB - We have quantitated the relative contributions of the constitutively active alpha4beta1 and alpha4beta7 integrins and the domains embodying their cognate binding sites in mediating human B-cell lymphoma adhesion and chemotaxis on fibronectin. By cooperating, the central cell-binding and IIICS carboxy-terminal domains were entirely responsible for the adhesion activity displayed by fibronectin, and their relative contribution to this process was estimated to be 30% versus 70%. Assessment of the leukocyte-substrate binding strength (ie, dynes/cell) indicated a 10-fold higher avidity of the cell-IIICS domain interaction. The two integrins interchangeably recognized both domains, but differed quantitatively in their participation in the adhesive event, as well as in domain preference. The use of 3Fn (according to the nomenclature proposed by Bork and Koonin [Curr Opin Struct Biol 6:366, 1996] for the type III fibronectin modules) module-specific antibodies and recombinant polypeptides showed that alpha4 integrins recognized both the RGD sequence (3Fn10) and an apparently novel synergistic site located within the 3Fn8 module; even in this case, the integrins displayed a distinct binding site preference. Interleukin-1beta (IL-1beta)/IL-2 induced chemotaxis also involved cooperative function of the central cell-binding and IIICS domains, but the mechanisms regulating this phenomenon differed markedly from those controlling cell adhesion. First, the relative contribution of the individual domains was comparable, but neither of the individual domains promoted migration to the extent observed on intact fibronectin. Secondly, alpha4beta1 and alpha4beta7 integrins were both involved in the domain-binding necessary for initiation of migration, but the relative contribution of each receptor in the chemotactic process was less disparate than for initial cell adhesion. Thirdly, the mode by which chemotactic B-lymphoma movement was supported by the central cell-binding domain differed from that sustaining cell adhesion in that it involved independent recognition of either the 3Fn8 or the 3Fn9 module, which acted in synergy with the 3Fn10 module. Our data provide novel evidence concerning the relative importance of the constitutively active alpha4beta1 and alpha4beta7 integrins for the interaction of B-cell lymphoma cells with fibronectin, and they emphasize a multiple and diverse recognition of sites responsible for either anchorage or locomotion of tumor leukocytes on this matrix molecule. PMID- 9949165 TI - A histomorphometric evaluation of heparin-induced bone loss after discontinuation of heparin treatment in rats. AB - Although it is well established that long-term heparin therapy causes osteoporosis, it is unknown whether heparin-induced bone loss is reversible when heparin treatment is stopped. To address this question, we randomized rats to once daily subcutaneous injections of either unfractionated heparin (1.0 U/g or 0.5 U/g) or saline for 28 days and then followed the rats for an additional 28 days off treatment. Based on histomorphometric analysis of the distal third of the right femur proximal to the epiphyseal growth plate, 1.0 U/g heparin caused a 30% loss in cancellous bone volume over the first 28 days. This was accompanied by a 137% increase in osteoclast surface and a 60% decrease in both osteoblast and osteoid surface. One month after cessation of heparin treatment, no recovery in these parameters was observed. Similarly, serum levels of alkaline phosphatase, a biochemical marker of bone formation, which continued to decrease over the course of heparin treatment, showed no signs of recovery in the subsequent 28 days off treatment. To explore the mechanism responsible for the prolonged effect of heparin on bone, we repeated the experiment giving 125I labeled heparin in place of unlabeled heparin. 125I-labeled heparin was found to accumulate in bone during the course of its administration, and be retained in bone for at least 56 days after stopping heparin treatment. These findings suggest that heparin-induced osteoporosis is not rapidly reversible because heparin is sequestered in bone for an extended period. PMID- 9949166 TI - Characterization of two naturally occurring mutations in the second epidermal growth factor-like domain of factor VII. AB - We investigated the mechanisms responsible for severe factor VII (FVII) deficiency in homozygous Italian patients with either Gly97Cys or Gln100Arg mutations in the second epidermal growth factor domain of FVII. Transient expression of complementary DNA coding for the mutations in COS-1 cells showed impaired secretion of the mutant molecules. Using stably transfected Chinese hamster ovary (CHO) cells, we performed pulse-chase labeling studies, immunohistochemistry, and experiments with inhibitors of protein degradation, showing that FVII-Cys97 did not accumulate intracellularly but was degraded in a pre-Golgi, nonlysosomal compartment by a cysteine protease. In stably transfected CHO cells expressing FVII-Arg100, the level of intracellular FVII was not increased by several inhibitors of protein degradation, but FVII-Arg100 was retained in the endoplasmic reticulum for a longer period of time than wild-type FVII. FVII-Arg100 had a lower apparent molecular weight than did wild-type FVII under nondenaturing conditions, which is attributable to misfolding due to abnormal disulfide bond formation. PMID- 9949168 TI - Maturation of embryonic stem cells into endothelial cells in an in vitro model of vasculogenesis. AB - A primitive vascular plexus is formed through coordinated regulation of differentiation, proliferation, migration, and cell-cell adhesion of endothelial cell (EC) progenitors. In this study, a culture system was devised to investigate the behavior of purified EC progenitors in vitro. Because Flk-1(+) cells derived from ES cells did not initially express other EC markers, they were sorted and used as EC progenitors. Their in vitro differentiation into ECs, via vascular endothelial-cadherin (VE-cadherin)+ platelet-endothelial cell adhesion molecule-1 (PECAM-1)+ CD34(-) to VE-cadherin+ PECAM-1(+) CD34(+) stage, occurred without exogenous factors, whereas their proliferation, particularly at low cell density, required OP9 feeder cells. On OP9 feeder layer, EC progenitors gave rise to sheet like clusters of Flk-1(+) cells, with VE-cadherin concentrated at the cell-cell junction. The growth was suppressed by Flt-1-IgG1 chimeric protein and dependent on vascular endothelial growth factor (VEGF) but not placenta growth factor (PIGF). Further addition of VEGF resulted in cell dispersion, indicating the role of VEGF in the migration of ECs as well as their proliferation. Cell-cell adhesion of ECs in this culture system was mediated by VE-cadherin. Thus, the culture system described here is useful in dissecting the cellular events of EC progenitors that occur during vasculogenesis and in investigating the molecular mechanisms underlying these processes. PMID- 9949167 TI - Sialylation of the sialic acid binding lectin sialoadhesin regulates its ability to mediate cell adhesion. AB - The macrophage-specific cell surface receptor sialoadhesin, which is a member of the newly recognized family of sialic acid binding lectins called siglecs, binds glycoprotein and glycolipid ligands containing a2-3-linked sialic acid on the surface of several leukocyte subsets. Recently, the sialic acid binding activity of the siglec CD22 has been demonstrated to be regulated by sialylation of the CD22 receptor molecule. In the present work, we show that desialylation of in vivo macrophage sialylconjugates enhances sialoadhesin-mediated lectin activity. Herein, we show that receptor sialylation of soluble sialoadhesin inhibits its binding to Jurkat cell ligands, and that charge-dependent repulsion alone cannot explain this inhibition. Furthermore, we show that the inhibitory effect of sialic acid is partially dependent on the presence of an intact exocyclic side chain. These results, in conjunction with previous findings, suggest that sialylation of siglecs by specific glycosyltransferases may be a common mechanism by which siglec-mediated adhesion is regulated. PMID- 9949169 TI - Enhanced endothelial cell apoptosis in splenic tissues of patients with thrombotic thrombocytopenic purpura. AB - Idiopathic thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy of obscure etiology. The fundamental pathologic lesion is a hyaline thrombus composed of platelets and some fibrin accompanied by endothelial cell proliferation and detachment, in the absence of an inflammatory response. We have previously demonstrated that plasmas from patients with both idiopathic TTP and a related disorder, sporadic hemolytic-uremic syndrome (HUS), induce apoptosis and expression of the apoptosis-associated molecule Fas (CD95) in vitro in those lineages of microvascular endothelial cells (MVECs) that are affected pathologically. We now demonstrate the presence of enhanced MVEC apoptosis in splenic tissues from patients with TTP, documented by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) and morphology. This is accompanied by elevated Fas expression. It contrasts with the absence of apoptosis in splenic tissues obtained after splenectomy for trauma or immune thrombocytopenic purpura. TUNEL-positive cells, identified by immunohistochemistry as MVECs or macrophages, presumably engulfing apoptotic ECs, are noted in numerous areas, including those apart from microthrombi. Thus, it is unlikely that EC apoptosis is simply a sequela of thrombus formation. Based on these data, we propose that MVEC apoptosis is of pathophysiologic significance in idiopathic TTP/sporadic HUS. PMID- 9949170 TI - A reduced sensitivity for activated protein C in the absence of factor V Leiden increases the risk of venous thrombosis. AB - Activated protein C (APC) resistance caused by the factor V Leiden mutation is associated with an increased risk of venous thrombosis. We investigated whether a reduced response to APC, not due to the factor V point mutation, is also a risk factor for venous thrombosis. For this analysis, we used the Leiden Thrombophilia Study (LETS), a case-control study for venous thrombosis including 474 patients with a first deep-vein thrombosis and 474 age- and sex-matched controls. All carriers of the factor V Leiden mutation were excluded. A dose-response relationship was observed between the sensitivity for APC and the risk of thrombosis: the lower the normalized APC sensitivity ratio, the higher the associated risk. The risk for the lowest quartile of normalized APC-SR (<0.92), which included 16.5% of the healthy controls, compared with the highest quartile (normalized APC-SR > 1.05) was greater than fourfold increased (OR = 4.4; 95% confidence interval, 2.9 to 6.6). We adjusted for VIII:C levels, which appeared to affect our APC resistance test. The adjusted (age, sex, FVIII:C) odds ratio for the lowest quartile was 2.5 (95% confidence interval, 1.5 to 4.2). So, after adjustment for factor VIII levels, a reduced response to APC remained a risk factor. Our results show that a reduced sensitivity for APC, not caused by the factor V Leiden mutation, is a risk factor for venous thrombosis. PMID- 9949171 TI - CD8 T-cell infiltration in extravascular tissues of patients with human immunodeficiency virus infection. Interleukin-15 upmodulates costimulatory pathways involved in the antigen-presenting cells-T-cell interaction. AB - Interleukin (IL)-15 regulates the proliferative activity of the CD8(+) T-cell pool in human immunodeficiency virus (HIV)-infected patients, thereby contributing to the maintenance of the CD8(+) T-cell-mediated immune response against HIV in extravascular tissues, including the lung. However, the effects of IL-15 on antigen-presenting cells (APC) during HIV infection are still unclear. In this study, we evaluated whether IL-15 regulates the macrophage stimulatory pathways governing inflammatory events that take place in the lung of patients with HIV infection. As a first step we evaluated the in vitro effects of IL-15 on lung macrophages retrieved from the respiratory tract of eight normal subjects. Although macrophages from uninfected individuals expressed the IL-15 binding proteins (IL-15Ralpha and the common gammac) at resting conditions, they did not express IL-15 messenger RNA (mRNA). However, a 24-hour stimulation with IL-15 induced the expression of interferon-gamma (IFN-gamma) and IL-15 itself, suggesting a role for this cytokine in the activation of the pulmonary macrophage pool during inflammation. As a confirmation of the role of IL-15 in this setting, at resting conditions, alveolar macrophages of patients with HIV infection and T cell alveolitis expressed IL-15, IFN-gamma, and IL-15 binding proteins; showed an upmodulation of costimulatory molecules, B7 and CD72, which are involved in the APC of macrophages; and behaved as effective accessory cells because they elicited a strong proliferation of T cells. The accessory effect was inhibited by pretreatment with anti-CD72, anti-B7 (CD80 and CD86), and anti-IL-15 monoclonal antibodies (MoAb). We then investigated the relationship between IL-15 and the expression of costimulatory molecules by macrophages. A 24-hour stimulation of IL 15Ralpha+/gammac+ macrophages with IL-15 upregulated the expression of CD80 and CD86. The evidence that IL-15 upregulates the expression of coligands that favor the contact between T cells and APC, per se, triggers T-cell activation and proliferation and acts as a chemoattractant for T cells, suggests that IL-15 plays a key role in Tc1-mediated defense mechanisms taking place in extravascular tissues of patients with HIV disease. PMID- 9949172 TI - Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone. AB - Monoclonal antibodies (MoAbs) that selectively identify Muc-1 core protein (MoAbs DF3-P, VU-4H5) determinants were used to identify the Muc-1 glycoform present on 7 multiple myeloma (MM) cell lines, 5 MM patient plasma cells, 12 MM patient B cells, as well as 32 non-MM cell lines and normal hematopoietic cells. Flow cytometry studies demonstrated that all MM cell lines, MM patient plasma cells, and MM patient B cells expressed Muc-1 core protein epitopes. Circulating B cells from 4 normal donors also expressed Muc-1 core protein. In contrast, Muc-1 core protein was absent on 28 of 32 non-MM neoplastic cell lines, 17 of which expressed Muc-1. Splenic and tonsillar B cells, CD34(+) stem cells, resting T cells, and bone marrow plasma cells obtained from normal donors both lacked Muc-1 glycoforms. We next studied the effects of estrogen, progesterone, and glucocorticoid receptor agonists and antagonists on Muc-1 expression, because consensus sequences for the response elements of these steroids are present on the Muc-1 gene promoter. These studies showed that dexamethasone (Dex) induced Muc-1 expression on MM cell lines, as determined by both flow cytometry and Western blot analyses. Dex also induced upregulation of Muc-1 on prostate and ovarian cancer cell lines. Time and dose-response studies demonstrated that Dex induced maximal cell surface Muc-1 expression by 24 hours at concentrations of 10(-8) mol/L. Dex induced Muc-1 upregulation could be blocked with a 10-fold excess of the glucocorticoid receptor antagonist RU486, confirming that Dex was acting via the glucocorticoid receptor. No changes in Muc-1 expression were observed on MM cells treated with estrogen and progesterone receptor agonists and antagonists or with RU486. These studies provide the framework for targeting Muc 1 core protein in vaccination and serotherapy trials in MM. In addition, the finding that Muc-1 expression on MM cells can be augmented by Dex at pharmacologically achievable levels suggests their potential utility in enhancing treatments targeting Muc-1 in MM. PMID- 9949173 TI - Interleukin-4 (IL-4) and IL-13 enhance the effect of IL-1beta on production of IL 1 receptor antagonist by human primary hepatocytes and hepatoma HepG2 cells: differential effect on C-reactive protein production. AB - Interleukin-1 receptor antagonist (IL-1Ra) is produced by hepatocytes with characteristics of an acute-phase protein. To examine the role of IL-4 and IL-13 in production of IL-1Ra, human primary hepatocytes and HepG2 human hepatoma cells were cultured in the presence of IL-4 or IL-13 in combination with IL-1beta and/or IL-6. The results indicated that both IL-4 and IL-13 amplified the stimulatory effect of IL-1beta on production of IL-1Ra protein and messenger RNA (mRNA) by both human primary hepatocytes and HepG2 cells. IL-1Ra refers to three different peptides, one secreted (sIL-1Ra) and two intracellular (icIL-1RaI and icIL-1RaII), derived from the same gene. sIL-1Ra and icIL-1RaI are the products of two different mRNA, whereas icIL-1RaII is synthesized by alternative translation initiation mainly from sIL-1Ra mRNA. Our results show that both sIL 1Ra and icIL-1RaII, but not icIL-1RaI, are produced by HepG2 cells and human hepatocytes. Transient transfection experiments as well as mRNA stability studies indicated that IL-4 stimulated sIL-1Ra production primarly at the level of transcription. Gel retardation assays showed that IL-4 induced the formation of a STAT6-DNA complex with a STAT6 binding element within the sIL-1Ra promoter, but had no effect on IL-1-induced NF-kappaB binding activity. In contrast to IL-1Ra, production of C-reactive protein by human primary hepatocytes was stimulated by IL-6 and decreased by the addition of IL-4. PMID- 9949174 TI - Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach. AB - We recently demonstrated that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme of de novo cholesterol synthesis, was a potential mediator of the biological effects of retinoic acid on human neuroblastoma cells. The HMG-CoA reductase inhibitor, lovastatin, which is used extensively in the treatment of hypercholesterolemia, induced a potent apoptotic response in human neuroblastoma cells. This apoptotic response was triggered at lower concentrations and occurred more rapidly than had been previously reported in other tumor-derived cell lines, including breast and prostate carcinomas. Because of the increased sensitivity of neuroblastoma cells to lovastatin-induced apoptosis, we examined the effect of this agent on a variety of tumor cells, including leukemic cell lines and primary patient samples. Based on a variety of cytotoxicity and apoptosis assays, the 6 acute lymphocytic leukemia cell lines tested displayed a weak apoptotic response to lovastatin. In contrast, the majority of the acute myeloid leukemic cell lines (6/7) and primary cell cultures (13/22) showed significant sensitivity to lovastatin-induced apoptosis, similar to the neuroblastoma cell response. Of significance, in the acute myeloid leukemia, but not the acute lymphocytic leukemia cell lines, lovastatin-induced cytotoxicity was pronounced even at the physiological relevant concentrations of this agent. Therefore, our study suggests the evaluation of HMG-CoA reductase inhibitors as a therapeutic approach in the treatment of acute myeloid leukemia. PMID- 9949175 TI - Activating mutation in the catalytic domain of c-kit elicits hematopoietic transformation by receptor self-association not at the ligand-induced dimerization site. AB - The c-kit receptor tyrosine kinase (KIT) is constitutively activated by naturally occurring mutations in either the juxtamembrane domain or the kinase domain. Although the juxtamembrane domain mutations led to ligand-independent KIT dimerization, the kinase domain mutations (Asp814 --> Val or Tyr) did not. In an effort to determine if the kinase domain mutant could transfer oncogenic signaling without receptor dimerization, we have constructed the truncated types of c-kitWild and c-kitTyr814 cDNAs (c-kitDel-Wild and c-kitDel-Tyr814 cDNAs, respectively), in which ligand-binding and ligand-induced dimerization domains were deleted. When c-kitDel-Wild and c-kitDel-Tyr814 genes were introduced into a murine interleukin-3 (IL-3)-dependent cell line Ba/F3, KITDel-Tyr814 was constitutively phosphorylated on tyrosine and activated, whereas KITDel-Wild was not. In addition, Ba/F3 cells expressing KITDel-Tyr814 (Ba/F3(Del-Tyr814)) grew in suspension culture without the addition of exogenous growth factor, whereas Ba/F3 cells expressing KITDel-Wild (Ba/F3(Del-Wild)) required IL-3 for growth. The factor-independent growth of Ba/F3(Del-Tyr814) cells was virtually abrogated by coexpression of KITW42 that is a dominant-negative form of KIT, but not by that of KITWild, suggesting that KITDel-Tyr814 may not function as a monomer but may require receptor dimerization for inducing factor-independent growth. Furthermore, KITDel-Tyr814 was found to be coimmunoprecipitated with KITWild or KITW42 by an ACK2 monoclonal antibody directed against the extracellular domain of KIT. Moreover, KITW42 was constitutively associated with a chimeric FMS/KITTyr814 receptor containing the ligand-binding and receptor dimerization domain of c-fms receptor (FMS) fused to the transmembrane and cytoplasmic domain of KITTyr814, but not with a chimeric FMS/KITWild receptor even after stimulation with FMS-ligand. These results suggest that constitutively activating mutation of c-kit at the Asp814 codon may cause a conformation change that leads to receptor self-association not in the extracellular domain and that the receptor self association of the Asp814 mutant may be important for activation of downstream effectors that are required for factor-independent growth and tumorigenicity. PMID- 9949176 TI - Molecular analysis of 11q13 breakpoints in multiple myeloma. AB - The t(11;14)(q13;q32) chromosomal translocation, which is the hallmark of mantle cell lymphoma (MCL), is found in approximately 30% of multiple myeloma (MM) tumors with a 14q32 translocation. Although the overexpression of cyclin D1 has been found to be correlated with MM cell lines carrying the t(11;14), rearrangements of the BCL-1/cyclin D1 regions frequently involved in MCL rarely occur in MM cell lines or primary tumors. To test whether specific 11q13 breakpoint clusters may occur in MM, we investigated a representative panel of primary tumors by means of Southern blot analysis using probes derived from MM associated 11q13 breakpoints. To this end, we first cloned the breakpoints and respective germ-line regions from a primary tumor and the U266 cell line, as well as the germ-line region from the KMS-12 cell line. DNA from 50 primary tumors was tested using a large panel of probes, but a rearrangement was detected in only one case using the KMS-12 breakpoint probe. Our results confirm previous findings that the 11q13 breakpoints in MM are scattered throughout the 11q13 region encompassing the cyclin D1 gene, thus suggesting the absence of 11q13 breakpoint clusters in MM. PMID- 9949177 TI - GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway. AB - The Bcr-Abl oncogene, found in Philadelphia chromosome-positive myelogenous leukemia (CML), activates Ras and triggers the stress-activated protein kinase (SAPK or Jun NH2-terminal kinase [JNK]) pathway. Interruption of Ras or SAPK activation dramatically reduces Bcr-Abl-mediated transformation. Here, we report that Bcr-Abl through a Ras-dependent pathway signals the serine/threonine protein kinase GCKR (Germinal Center Kinase Related) leading to SAPK activation. Either an oncogenic form of Ras or Bcr-Abl enhances GCKR catalytic activity and its activation of SAPK, whereas inhibition of GCKR impairs Bcr-Abl-induced SAPK activation. Bcr-Abl mutants that are impaired for GCKR activation are also unable to activate SAPK. Consistent with GCKR being a functional target in CML, GCKR is constitutively active in CML cell lines and found in association with Bcr-Abl. Our results indicate that GCKR is a downstream target of Bcr-Abl and strongly implicate GCKR as a mediator of Bcr-Abl in its transformation of cells. PMID- 9949178 TI - Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells. AB - A unique subclone of a bone marrow-derived stromal cell line, BMS2.4, produces soluble factors that inhibit proliferation of several types of hematopoietic cell lines. An understanding of these molecules may be informative about negative regulatory circuits that can potentially limit blood cell formation. We used expression cloning to identify interleukin-6 (IL-6) as one factor that suppressed growth of a pre-B-cell variant line, 1A9-M. Moreover, IL-6 induced macrophage differentiation and apoptosis of 1A9-M cells. During this process, IL-6 downregulated expression of BCL2 in 1A9-M cells and stimulated BCL-XL expression, but had no effect on p53, Bax, or Bak gene expression. Mechanisms for transduction of IL-6-induced signals were then evaluated in IL-6-stimulated 1A9-M cells. Whereas the signal transducer and activator of transcription 3 (Stat3) was phosphorylated and activated, there was no effect on either Stat1 or Stat5. The importance of BCL2 and Stat3 on IL-6-induced macrophage-differentiation and apoptosis was studied with 1A9-M cells expressing human BCL2 or a dominant negative form of Stat3, respectively. IL-6-induced apoptosis, but not macrophage differentiation, was blocked by continuously expressed BCL2. A dominant-negative form of Stat3 inhibited both macrophage-differentiation and apoptosis induced by IL-6. However, diminished Stat3 activity did not prevent IL-6-induced downregulation of the BCL2 gene. Therefore, activation of Stat3 is essential for IL-6-induced macrophage-differentiation and programmed cell death in this model. Whereas overexpression of BCL2 abrogates the apoptotic response, Stat3 independent signals appear to downregulate expression of the BCL2 gene. PMID- 9949179 TI - Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25). AB - Chromosome translocations involving band 12p13 are known to be involved in a variety of hematologic malignancies, some of them resulting in rearrangement of the ETV6/TEL gene. Applying the fluorescence in situ hybridization (FISH) method, we found a cryptic translocation t(12;15)(p13;q25) in an adult acute myeloid leukemia (AML) patient. Hybridization with cosmid probes showed that the ETV6 gene was rearranged in this translocation. A patient-specific cDNA library was screened with ETV6 cDNA, and a novel fusion transcript was identified between the ETV6 and TRKC/NTRK3 gene located on 15q25. TRKC is a receptor tyrosine kinase that is activated by neurotrophin-3 (NT-3). It is known to be expressed broadly in neural tissues but not in hematologic cells, so far. ETV6-TRKC chimeric transcript encoded the pointed (PNT) domain of the ETV6 gene that fused to the protein-tyrosine kinase (PTK) domain of the TRKC gene. Two types of fusion transcript were determined, one that included the entire PTK domain of TRKC and the other in which the 3'-terminal 462 bp of TRKC was truncated within the PTK domain. Western blot analysis showed the expression of both chimeric proteins of 52 and 38 kD in size. Our results suggest that chimeric PTK expressed in the leukemic cells may contribute to cellular transformation by abnormally activating TRK signaling pathways. Moreover, this is the first report on truncated neurotrophin receptors associated in leukemia. PMID- 9949180 TI - Proliferation and apoptosis-related gene expression in experimental acquired immunodeficiency syndrome-related simian lymphoma. AB - Lymphomas in 10 cynomolgus monkeys infected with a simian immunodeficiency virus (SIVsm) were studied with regard to proliferative activity and apoptosis-related gene expression. All were diffuse large-cell lymphomas, showed mono or oligoclonality and a 9/10 diploid cellular DNA content. Expression of a simian homologue to Epstein-Barr virus (HVMF-1) was shown in nine cases. The lymphomas showed moderate to high proliferative activity by Ki67 immunostaining and DNA flow cytometry, and a low number of apoptotic cells detected by TdT-mediated dUTP nick-end labeling (TUNEL). Immunohistochemistry showed abundant tumor infiltrating TIA-1(+) cytotoxic lymphocytes (CTL) and macrophages. Bcl-2, Mcl-1, and also Bax and Bak, but not p53 were demonstrable in the tumor cells by immunostaining. Our findings suggest a causal relationship between HVMF-1 infection and a low apoptotic index of the lymphomas due to the expression of Bcl 2. The apparent inefficient function of tumor-infiltrating CTL could be due to inactivation of CTL and/or resistance of the lymphoma cells to CTL effects. The tumors showed immunoreactivity for CD18, CD29, and CD49d, but not for CD11a, mimicking the phenotype of human Epstein-Barr virus (EBV)-related lymphomas. In summary, our observations indicate a high similarity between this simian model of acquired immunodeficiency syndrome (AIDS)-related lymphomas (ARL) and human ARL and other immunosuppression-related lymphomas. PMID- 9949181 TI - Cytogenetic profile of lymphoma of follicle mantle lineage: correlation with clinicobiologic features. AB - Conventional chromosome analysis (CCA) and interphase fluorescence in situ hybridization (FISH) was performed in 42 patients with mantle-cell lymphoma (MCL), with BCL1 rearrangement. The t(11;14)(q13;q32) or 11q abnormalities were detected by CCA in 34 cases, 20 of which had additional aberrations. A normal karyotype was observed in 8 cases. Probes detecting the chromosome aberrations that were observed in at least 3 cases by CCA, ie, +12, 13q14 deletion, and 17p deletion, were used for interphase FISH analysis. FISH detected total or partial +12, 13q14 deletion and 17p- in 28.5%, 52.4%, and 26% of the cases, respectively. The presence of these anomalies was not a function of karyotype complexity. Based on the results of CCA/FISH, three groups of increasing karyotype complexity were recognized: group 1, including 11 patients without detectable aberrations in addition to BCL1 rearrangement; group 2, including 14 patients with 1 to 2 additional anomalies; and group 3, including 17 patients with three or more additional anomalies. Clinical parameters associated with shorter survival were male sex (P =.006) and primary lymph-node involvement compared with primary bone marrow involvement (P =.015). Trisomy 12 was the only single cytogenetic parameter predictive of a poor prognosis (P =.006) and the best prognostic indicator was the derived measure of karyotype complexity (P <.0001), which maintained statistical significance in multivariate analysis (P<.0001). We arrived at the following conclusions: 13q14 deletion occurs at a high incidence in MCL; 17p deletion and total/partial +12 are relatively frequent events in MCL, the latter aberration being associated with a shorter survival; and the degree of karyotype complexity has a strong impact on prognosis in this neoplasia. PMID- 9949182 TI - The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. AB - In patients with an atypical stem-cell myeloproliferative disorder with lymphoma (B or T cell), myeloid hyperplasia, and eosinophilia, the chromosome 8p11-12 region is the site of a recurrent breakpoint that can be associated with three different partners, 6q27, 9q32-34, and 13q12. Rearrangements are supposed to affect a pluripotent stem cell capable of myeloid and lymphoid differentiation and to involve the same 8p11-12 gene. The t(8;13) translocation has recently been shown to result in a fusion between the FGFR1 gene that encodes a tyrosine kinase receptor for fibroblast growth factors and a novel gene, FIM (also called RAMP or ZNF198), belonging to a novel family of zinc finger genes. In the present study, we have cloned the t(6;8)(q27;p11) translocation in two patients and found a fusion between FGFR1 and a novel gene, FOP (FGFR1 Oncogene Partner), located on chromosome band 6q27. This gene is alternatively spliced and ubiquitously expressed. It encodes a protein containing two regions of putative leucine-rich repeats putatively folding in alpha-helices and separated by a hydrophobic spacer. The two reciprocal fusion transcripts were evidenced by reverse transcription-polymerase chain reaction in the tumoral cells of the patients. The predicted chimeric FOP-FGFR1 protein contains the FOP N-terminus leucine-rich region fused to the catalytic domain of FGFR1. It may promote hematopoietic stem cell proliferation and leukemogenesis through a constitutive phosphorylation and activation of the downstream pathway of FGFR1. PMID- 9949183 TI - p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells. AB - A recent hypothesis suggests that tumor-specific killing by radiation and chemotherapy agents is due to defects or loss of cell cycle checkpoints. An important component of some checkpoints is p53-dependent induction of p21(cip 1/waf-1). Both p53 and p21 have been shown to be required for microtubule damage checkpoints in mitosis and in G1 phase of the cell cycle and they thus help to maintain genetic stability. We present here evidence that p21(cip-1/waf-1) deficiency relaxes the G1 phase microtubule checkpoint that is activated by microtubule damage induced with nocodazole. Reduced p21(cip-1/waf-1) expression also results in gross nuclear abnormalities and centriole overduplication. p53 has already been implicated in centrosome regulation. Our findings further suggest that the p53/p21 axis is involved in a checkpoint pathway that links the centriole/centrosome cycle and microtubule organization to the DNA replication cycle and thus helps to maintain genomic integrity. The inability to efficiently upregulate p21(cip-1/waf-1) in p21(cip-1/waf-1) antisense-expressing cells in response to microtubule damage could uncouple the centrosome cycle from the DNA cycle and lead to nuclear abnormalicies and polyploidy. A centrosome duplication checkpoint could be a new target for novel chemotherapy strategies. PMID- 9949184 TI - Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. AB - Because arachidonate metabolites are potent mediators of inflammation, we have studied the effects of leukotriene B4 (LTB4) and the cysteinyl leukotrienes C4 and D4 (LTC4 and LTD4) on the release of nitric oxide (NO), in vitro, by human polymorphonuclear granulocytes (PMN). Two independent and highly sensitive real time methods were used for these studies, ie, the NO-dependent oxidation of oxyhemoglobin (HbO2) to methemoglobin and a NO-sensitive microelectrode. When activated with LTB4, LTC4, or LTD4, but not with other lipoxygenase products such as 5S-HETE, 5-oxo-ETE or 5S, 12S-diHETE, PMN produced NO in a stimulus- and concentration-dependent manner. The rank order of potency was LTB4 = LTC4 > LTD4, corresponding to 232 +/- 50 pmol of NO/10(6) PMN for 100 nmol/L LTB4 after 30 minutes. The kinetic properties of the responses were similar for all three leukotrienes with a maximum response at 13 +/- 3 minutes. Cysteinyl leukotriene and LTB4 antagonists inhibited the agonist-induced NO production by 70%, and treatment with Bordetella pertussis toxin, or chelation of cytosolic Ca2+, [Ca2+]i, also efficiently inhibited this response. In contrast, treatment of PMN with cytochalasin B (5 microg/mL) enhanced the LTB4-induced NO formation by 86%. Thus, this is the first demonstration that the cysteinyl leukotrienes LTC4 and LTD4, as well as LTB4, activate NO release from human PMN by surface receptor, G protein and [Ca2+]i-dependent mechanisms. This effect differs from activation of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, for which only LTB4 is an activator. PMID- 9949185 TI - Previous uptake of apoptotic neutrophils or ligation of integrin receptors downmodulates the ability of macrophages to ingest apoptotic neutrophils. AB - Clearance of apoptotic neutrophils (polymorphonuclear leukocyte [PMN]) by macrophages is thought to play a crucial role in resolution of acute inflammation. There is increasing evidence that ingestion of apoptotic cells modulates macrophage behavior. We therefore performed experiments to determine whether ingestion of apoptotic PMN modulated the uptake process itself. Rat bone marrow-derived macrophages (BMDM) ingested apoptotic PMN by a process that was enhanced by tumor necrosis factor (TNF) and attenuated by interferon (IFN)-gamma, interleukin (IL)-4, and IL-10. It was inhibitable by the tetrapeptide arg-gly-gln ser (RGDS), therefore implicating the alphavbeta3/CD36/thrombospondin pathway. Interaction of apoptotic PMN with BMDM for 30 minutes, 48 hours before rechallenge reduced uptake of apoptotic PMN by 50% compared with previously unchallenged BMDM. Blocking initial uptake with RGDS abrogated the effect of preexposure. Comparable and sustained attenuation of uptake was obtained by ligating alphavbeta3 with the monoclonal antibody (MoAb), F11, after a delay of more than 90 minutes, whereas MoAbs to CD25 and CD45 had no effect. Ligation of alpha6beta1 and alpha1beta2, integrins not previously implicated in the engulfment of apoptotic cells also decreased uptake with similar kinetics to F11. Therefore, apoptotic PMN regulate their own uptake through an integrin-dependent process, which can be reproduced by ligation of other integrins expressed by macrophages. PMID- 9949186 TI - Oncostatin M production and regulation by human polymorphonuclear neutrophils. AB - Oncostatin M (OSM) is an interleukin-6 (IL-6) family cytokine known in particular to induce the synthesis of acute-phase proteins by hepatocytes. Because human polymorphonuclear neutrophils (PMN) can secrete numerous cytokines, the potential production of OSM by PMN was investigated. Highly purified PMN were found to contain an intracellular stock of preformed OSM that was rapidly mobilized by degranulating agents such as phorbol myristate acetate and granulocyte-macrophage colony-stimulating factor (GM-CSF). Moreover, PMN produced OSM after a few hours of stimulation by various agonists. The most potent effect was observed with the combination of lipopolysaccharide and GM-CSF, which had a concentration- and time dependent effect at both the protein and mRNA levels. Actinomycin D strongly reduced OSM mRNA induction, suggesting the involvement of gene transcription. Cycloheximide inhibited OSM protein synthesis but did not affect the release of preformed stores. In addition, OSM production was downregulated by dexamethasone, whereas IL-10 had no effect. The OSM produced by PMN was biologically active, as demonstrated by its ability to induce alpha1-acid glycoprotein synthesis by HepG2 cells. OSM secretion thus occurs through a two-step mechanism in PMN, consisting of early release of a preformed stock, followed by de novo protein synthesis. This would allow rapid and sustained OSM release to occur at inflammatory sites, and may contribute to the modulation of local inflammation. PMID- 9949187 TI - Anionic polysaccharides inhibit adhesion of sickle erythrocytes to the vascular endothelium and result in improved hemodynamic behavior. AB - The abnormal adherence of sickle red blood cells (SS RBC) to vascular endothelium may play an important role in vasoocclusion in sickle cell anemia. Thrombospondin (TSP), unusually large molecular weight forms of von Willebrand factor, and laminin are known to enhance adhesion of SS RBC. Also, these endothelial proteins bind to sulfated glycolipids and this binding is inhibited by anionic polysaccharides. Reversible sickling may expose normally cryptic membrane sulfatides that could mediate this adhesive interaction. In this study, we have investigated the effect of anionic polysaccharides, in the presence or absence of TSP, on SS RBC adhesion to the endothelium, using cultured human umbilical vein endothelial cells (HUVEC) (for the adhesion assay) and the ex vivo mesocecum of the rat (for hemodynamic evaluation). The baseline adhesion (ie, without added TSP) of SS RBC to HUVEC was most effectively inhibited by high molecular weight dextran sulfate (HDS), whereas low molecular weight dextran sulfate (LDS) and the glycosaminoglycan chondroitin sulfate A (CSA) also had significant inhibitory effects. Heparin was mildly effective whereas other glycosaminoglycans (chondroitin sulfates B and C, heparan sulfate, and fucoidan) were ineffective. Similarly, HDS and CSA resulted in an improved hemodynamic behavior of SS RBC. Soluble TSP caused significant increases in SS RBC adhesion and in the peripheral resistance. Both HDS and CSA prevented TSP-enhanced adhesion and hemodynamic abnormalities. Thus, anionic polysaccharides can inhibit SS RBC-endothelium interaction in the presence or absence of soluble TSP. These agents may interact with RBC membrane component(s) and prevent TSP-mediated adhesion of SS RBC to the endothelium. PMID- 9949188 TI - Tenascin-C inhibits beta1 integrin-dependent cell adhesion and neurite outgrowth on fibronectin by a disialoganglioside-mediated signaling mechanism. AB - We have previously shown that the extracellular matrix molecule tenascin-C inhibits fibronectin-mediated cell adhesion and neurite outgrowth by an interaction with a cellular RGD-independent receptor which interferes with the adhesion and neurite outgrowth promoting activities of the fibronectin receptor(s). Here we demonstrate that the inhibitory effect of tenascin-C on beta1integrin-dependent cell adhesion and neurite outgrowth is mediated by the interaction of the protein with membrane-associated disialogangliosides, which interferes with protein kinase C-related signaling pathways. First, in substratum mixtures with fibronectin, an RGD sequence-containing fragment of the molecule or synthetic peptide, tenascin-C inhibited cell adhesion and spreading by a disialoganglioside-dependent, sialidase-sensitive mechanism leading to an inhibition of protein kinase C. Second, the interaction of intact or trypsinized, i.e., cell surface glycoprotein-free, cells with immobilized tenascin-C was strongly inhibited by gangliosides or antibodies to gangliosides and tenascin-C. Third, preincubation of immobilized tenascin-C with soluble disialogangliosides resulted in a delayed cell detachment as a function of time. Similar to tenascin C, immobilized antibody to GD2 (3F8) or sphingosine, a protein kinase C inhibitor, strongly inhibited RGD-dependent cell spreading. Finally, the degree of tenascin-C-induced inhibition of cell adhesion was proportional to the degree of disialoganglioside levels of expression by different cells suggesting the relevance of such mechanism in modulating integrin-mediated cell-matrix interactions during pattern formation or tumor progression. PMID- 9949189 TI - Bovine mammary gland UDP-GalNAc:GlcNAcbeta-R beta1-->4-N acetylgalactosaminyltransferase is glycoprotein hormone nonspecific and shows interaction with alpha-lactalbumin. AB - We have identified a novel N -acetylgalactosaminyltransferase activity in lactating bovine mammary gland membranes. Acceptor specificity studies and analysis of products obtained in vitro by 400 MHz1H-NMR spectroscopy revealed that the enzyme catalyses the transfer of N -acetylgalactosamine (GalNAc) from UDP-GalNAc to acceptor substrates carrying a terminal, beta-linked N acetylglucosamine (GlcNAc) residue and establishes a beta1-->4-linkage forming a GalNAcbeta1-->4GlcNAc ( N, N '-diacetyllactosediamine, lacdiNAc) unit. Therefore, the enzyme can be identified as a UDP-GalNAc:GlcNAcbeta-R beta1-->4-N acetylgalactosaminyltransferase (beta4-GalNAcT). This enzyme resembles invertebrate beta4-GalNAcT as well as mammalian beta4-galactosyltransferase (beta4-GalT) in acceptor specificity. It can, however, be clearly distinguished from the pituitary hormone-specific beta4-GalNAcT by its incapability of acting with an elevated activity on a glycoprotein substrate carrying a hormone-specific peptide motif. Furthermore, the GalNAcT activity appeared not to be due to a promiscuous action of a beta4-GalT as could be demonstrated by comparing the beta4-GalNAcT and beta4-GalT activities of the mammary gland, bovine colostrum, and purified beta4-GalT, by competition studies with UDP-GalNAc and UDP-Gal, and by use of an anti-beta4-GalT polyclonal inhibiting antibody. Interestingly, under conditions where mammalian beta4-GalT forms with alpha-lactalbumin (alpha-LA) the lactose synthase complex, the mammary gland beta4-GalNAcT was similarly induced by alpha-LA to act on Glc with an increased efficiency yielding the lactose analog GalNAcbeta1-->4Glc. This enzyme thus forms the second example of a mammalian glycosyltransferase the specificity of which can be modified by this milk protein. It is proposed that the mammary gland beta4-GalNAcT functions in the synthesis of lacdiNAc-based, complex-type glycans frequently occurring on bovine milk glycoproteins. The action of this enzyme is to be considered when aiming at the production of properly glycosylated protein biopharmaceuticals in the milk of transgenic dairy animals. PMID- 9949190 TI - Incorporation of 15N from ammonium into the N-linked oligosaccharides of an immunoadhesin glycoprotein expressed in Chinese hamster ovary cells. AB - Elevated ammonium concentrations in the medium of cultivated cells have been shown to increase the intracellular levels of uridine-5'-diphospho-N acetylglucosamine (UDP-GlcNAc) and uridine-5'-diphospho-N-acetylgalactosamine (UDP-GalNAc; Ryll et al., 1994). These sugar nucleotides are substrates for glycosyltransferases in the glycosylation pathway. In our experiments, recombinant Chinese hamster ovary cells producing an immunoadhesin glycoprotein (GP1-IgG) have been cultivated under controlled cell culture conditions in the presence of different ammonium concentrations.15N-Labeled ammonium chloride (15NH4Cl) was added exogenously to the cell culture media to determine if ammonium was incorporated into UDP-GlcNAc and cytidine-5'-monophospho-N acetylneuraminic acid (CMP-NANA) pools, and subsequently incorporated into GP1 IgG as N-linked glycans. The intracellular pools of UDP-activated hexosamines (UDP-GNAc) were followed during the time course of the experiment. To assess the extent of15NH4+incorporation into the glycans of GP1-IgG, the glycoprotein was first purified to homogeneity by protein A chromatography. Enzymatically released N-glycans were then analyzed by matrix-assisted laser desorption/ionization time of-flight mass spectrometry. N-Glycans synthesized in the presence of15NH4Cl revealed an N-glycan-dependent increase in mass-to-charge of 2.5-4.8 Da. These results indicate that 60-70% of the total nitrogen containing monosaccharides had incorporated15N. Presumably,15NH4+was incorporated into GlcNAc and N acetylneuraminic acid as proposed earlier (Ryll et al., 1994). This might be a universal and previously not described reaction in mammalian cells when exposed to nonphysiological but in cell culture commonly found concentrations of ammonium. The data presented here are of significance for glycoprotein production in mammalian cell culture, since it has been shown previously that elevated levels of UDP-activated hexosamines affect N-glycan characteristics such as branching and degree of amino sugar incorporation. In addition, our results demonstrate that isotope labeling in combination with MALDI-TOF-MS can be used as an alternate tool to radioactive labeling of sugar substrates in metabolic studies. PMID- 9949191 TI - Coexpression of alpha1,2 galactosyltransferase and UDP-galactose transporter efficiently galactosylates N- and O-glycans in Saccharomyces cerevisiae. AB - We have studied in vivo neo-galactosylation in Saccharomyces cerevisiae and analyzed the critical factors involved in this system. Two heterologous genes, gma12(+) encoding alpha1, 2-galactosyltransferase (alpha1,2 GalT) from Schizosaccharomyces pombe and UGT2 encoding UDP-galactose (UDP-Gal) transporter from human, were functionally expressed to examine the intracellular conditions required for galactosylation. Detection by fluorescence labeled alpha-galactose specific lectin revealed that 50% of the cells incorporated galactose to cell surface mannoproteins only when the gma12(+) and hUGT2 genes were coexpressed in galactose media. Integration of both genes in the Delta mnn1 background cells increased galactosylation to 80% of the cells. Correlation between cell surface galactosylation and UDP-galactose transport activity indicated that an exogenous supply of UDP-Gal transporter rather than alpha1,2 GalT played a key role for efficient galactosylation in S.cerevisiae. In addition, this heterologous system enabled us to study the in vivo function of S. pombe alpha1,2 GalT to prove that it transfers galactose to both N - and O -linked oligosaccharides. Structural analysis indicated that this enzyme transfers galactose to O -mannosyl residue attached to polypeptides and produces Galalpha1,2-Man1-O-Ser/Thr structure. Thus, we have successfully generated a system for efficient galactose incorporation which is originally absent in S. cerevisiae, suggesting further possibilities for in vivo glycan remodeling toward therapeutically useful galactose containing heterologous proteins in S. cerevisiae. PMID- 9949192 TI - Interactions of neural glycosaminoglycans and proteoglycans with protein ligands: assessment of selectivity, heterogeneity and the participation of core proteins in binding. AB - The method of affinity coelectrophoresis was used to study the binding of nine representative glycosaminoglycan (GAG)-binding proteins, all thought to play roles in nervous system development, to GAGs and proteoglycans isolated from developing rat brain. Binding to heparin and non-neural heparan and chondroitin sulfates was also measured. All nine proteins-laminin-1, fibronectin, thrombospondin-1, NCAM, L1, protease nexin-1, urokinase plasminogen activator, thrombin, and fibroblast growth factor-2-bound brain heparan sulfate less strongly than heparin, but the degree of difference in affinity varied considerably. Protease nexin-1 bound brain heparan sulfate only 1.8-fold less tightly than heparin (Kdvalues of 35 vs. 20 nM, respectively), whereas NCAM and L1 bound heparin well (Kd approximately 140 nM) but failed to bind detectably to brain heparan sulfate (Kd>3 microM). Four proteins bound brain chondroitin sulfate, with affinities equal to or a few fold stronger than the same proteins displayed toward cartilage chondroitin sulfate. Overall, the highest affinities were observed with intact heparan sulfate proteoglycans: laminin-1's affinities for the proteoglycans cerebroglycan (glypican-2), glypican-1 and syndecan-3 were 300- to 1800-fold stronger than its affinity for brain heparan sulfate. In contrast, the affinities of fibroblast growth factor-2 for cerebroglycan and for brain heparan sulfate were similar. Interestingly, partial proteolysis of cerebroglycan resulted in a >400-fold loss of laminin affinity. These data support the views that (1) GAG-binding proteins can be differentially sensitive to variations in GAG structure, and (2) core proteins can have dramatic, ligand specific influences on protein-proteoglycan interactions. PMID- 9949193 TI - An essential saccharide binding domain for the mAb 2C7 established for Neisseria gonorrhoeae LOS by ES-MS and MSn. AB - A study of bacterial surface oligosaccharides were investigated among different strains of Neisseria gonorrhoeae to correlate structural features essential for binding to the MAb 2C7. This epitope is widely expressed and conserved in gonococcal isolates, characteristics essential to an effective candidate vaccine antigen. Sample lipooligosaccharides (LOS), was prepared by a modification of the hot phenol-water method from which de-O-acetylated LOS and oligosaccharide (OS) components were analyzed by ES-MS-CID-MS and ES-MSnin a triple quadrupole and an ion trap mass spectrometer, respectively. Previously documented natural heterogeneity was apparent from both LOS and OS preparations which was admixed with fragments induced by hydrazine and mild acid treatment. Natural heterogeneity was limited to phosphorylation and antenni extensions to the alpha chain. Mild acid hydrolysis to release OS also hydrolyzed the beta(1-->6) glycosidic linkage of lipid A. OS structures were determined by collisional and resonance excitation combined with MS and multistep MSn which provided sequence information from both neutral loss, and nonreducing terminal fragments. A comparison of OS structures, with earlier knowledge of MAb binding, enzyme treatment, and partial acid hydrolysis indicates a generic overlapping domain for 2C7 binding. Reoccurring structural features include a Hepalpha(1-->3)Hepbeta(1- >5)KDO trisaccharide core branched on the nonreducing terminus (Hep-2) with an alpha(1-->2) linked GlcNAc (gamma-chain), and an alpha-linked lactose (beta chain) residue. From the central heptose (Hep-1), a beta(1-->4) linked lactose (alpha-chain), moiety is required although extensions to this residue appear unnecessary. PMID- 9949194 TI - Purification and characterization of Dolichos lablab lectin. AB - The mannose/glucose-binding Dolichos lablab lectin (designated DLL) has been purified from seeds of Dolichos lablab (hyacinth bean) to electrophoretic homogeneity by affinity chromatography on an ovalbumin-Sepharose 4B column. The purified lectin gave a single symmetric protein peak with an apparent molecular mass of 67 kDa on gel filtration chromatography, and five bands ranging from 10 kDa to 22 kDa upon SDS-PAGE. N-Terminal sequence analysis of these bands revealed subunit heterogeneity due to posttranslational proteolytic truncation at different sites mostly at the carboxyl terminus. The carbohydrate binding properties of the purified lectin were investigated by three different approaches: hemagglutination inhibition assay, quantitative precipitation inhibition assay, and ELISA. On the basis of these studies, it is concluded that the Dolichos lablab lectin has neither an extended carbohydrate combining site, nor a hydrophobic binding site adjacent to it. The carbohydrate combining site of DLL appears to most effectively accommodate a nonreducing terminal alpha-d mannosyl unit, and to be complementary to the C-3, C-4, and C-6 equatorial hydroxyl groups of alpha-d-mannopyranosyl and alpha-d-glucopyranosyl residues. DLL strongly precipitates murine IgM but not IgG, and the recent finding that this lectin interacts specifically with NIH 3T3 fibroblasts transfected with the Flt3 tyrosine kinase receptor and preserves human cord blood stem cells and progenitors in a quiescent state for prolonged periods in culture, make this lectin a valuable tool in biomedical research. PMID- 9949195 TI - Protein glycosylation mutants of procyclic Trypanosoma brucei: defects in the asparagine-glycosylation pathway. AB - We employed a genetic approach to study protein glycosylation in the procyclic form of the parasite Trypanosoma brucei. Two different mutant parasites, ConA 1-1 and ConA 4-1, were isolated from mutagenized cultures by selecting cells which resisted killing or agglutination by concanavalin A. Both mutant cells show reduced concanavalin A binding. However, the mutants have different phenotypes, as indicated by the fact that ConA 1-1 binds to wheat germ agglutinin but ConA 4 1 and wild type do not. A blot probed with concanavalin A revealed that many proteins in both mutants lost the ability to bind this lectin, and the blots resembled one of wild type membrane proteins treated with PNGase F. This finding suggested that the mutants had altered asparagine-linked glycosylation. This conclusion was confirmed by studies on a flagellar protein (Fla1) and procyclic acidic repetitive protein (PARP). Structural analysis indicated that the N- glycan of wild type PARP is exclusively Man5GlcNAc2 whereas that in both mutants is predominantly a hybrid type with a terminal N- acetyllactosamine. The occupancy of the PARP glycosylation site in ConA 4-1 was much lower than that in ConA 1-1. These mutants will be useful for studying trypanosome glycosylation mechanisms and function. PMID- 9949196 TI - Expression of human alpha-l-fucosyltransferase gene homologs in monkey kidney COS cells and modification of potential fucosyltransferase acceptor substrates by an endogenous glycosidase. AB - Previous investigations on the monkey kidney COS cell line demonstrated the weak expression of fucosylated cell surface antigens and presence of endogenous fucosyltransferase activities in cell extracts. RT-PCR analyses have now revealed expression of five homologs of human fucosyltransferase genes, FUT1, FUT4, FUT5, FUT7, and FUT8, in COS cell mRNA. The enzyme in COS cell extracts acting on unsialylated Type 2 structures is closely similar in its properties to the alpha1,3-fucosyltransferase encoded by human FUT4 gene and does not resemble the product of the FUT5 gene. Although FUT1 is expressed in the COS cell mRNA, it has not been possible to demonstrate alpha1,2-fucosyltransferase activity in cell extracts but the presence of Le(y) and blood-group A antigenic determinants on the cell surface imply the formation of H-precursor structures at some stage. The most strongly expressed fucosyltransferase in the COS cells is the alpha1,6 enzyme transferring fucose to the innermost N -acetylglucosamine unit in N glycan chains; this enzyme is similar in its properties to the product of the human FUT8 gene. The enzymes resembling the human FUT4 and FUT8 gene products both had pH optima of 7.0 and were resistant to 10 mM NEM. The incorporation of fucose into asialo-fetuin was optimal at 5.5 and was inhibited by 10 mM NEM. This result initially suggested the presence of a third fucosyltransferase expressed in the COS cells but we have now shown that triantennary N- glycans with terminal nonreducing galactose units, similar to those present in asialo-fetuin, are modified by a weak endogenous beta-galactosidase in the COS cell extracts and thereby rendered suitable substrates for the alpha1,6-fucosyltransferase. PMID- 9949197 TI - Distribution of emerin and lamins in the heart and implications for Emery Dreifuss muscular dystrophy. AB - Emerin is a nuclear membrane protein which is missing or defective in Emery Dreifuss muscular dystrophy (EDMD). It is one member of a family of lamina associated proteins which includes LAP1, LAP2 and lamin B receptor (LBR). A panel of 16 monoclonal antibodies (mAbs) has been mapped to six specific sites throughout the emerin molecule using phage-displayed peptide libraries and has been used to localize emerin in human and rabbit heart. Several mAbs against different emerin epitopes did not recognize intercalated discs in the heart, though they recognized cardiomyocyte nuclei strongly, both at the rim and in intranuclear spots or channels. A polyclonal rabbit antiserum against emerin did recognize both nuclear membrane and intercalated discs but, after affinity purification against a pure-emerin band on a western blot, it stained only the nuclear membrane. These results would not be expected if immunostaining at intercalated discs were due to a product of the emerin gene and, therefore, cast some doubt upon the hypothesis that cardiac defects in EDMD are caused by absence of emerin from intercalated discs. Although emerin was abundant in the membranes of cardiomyocyte nuclei, it was absent from many non-myocyte cells in the heart. This distribution of emerin was similar to that of lamin A, a candidate gene for an autosomal form of EDMD. In contrast, lamin B1 was absent from cardiomyocyte nuclei, showing that lamin B1 is not essential for localization of emerin to the nuclear lamina. Lamin B1 is also almost completely absent from skeletal muscle nuclei. In EDMD, the additional absence of lamin B1 from heart and skeletal muscle nuclei which already lack emerin may offer an alternative explanation of why these tissues are particularly affected. PMID- 9949198 TI - Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism. AB - A mouse model of Rubinstein-Taybi syndrome (RTS) was generated by an insertional mutation into the cyclic AMP response element-binding protein (CREB)-binding protein (CBP) gene. Heterozygous CBP-deficient mice, which had truncated CBP protein (residues 1-1084) containing the CREB-binding domain (residues 462-661), showed clinical features of RTS, such as growth retardation (100%), retarded osseous maturation (100%), hypoplastic maxilla with narrow palate (100%), cardiac anomalies (15%) and skeletal abnormalities (7%). Truncated CBP is considered to have been acting during development as a dominant-negative inhibitor to lead to the phenotypes of RTS in mice. Our studies with step-through-type passive avoidance tests and with fear conditioning test showed that mice were deficient in long-term memory (LTM). In contrast, short-term memory (STM) appeared to be normal. These results implicate a crucial role for CBP in mammalian LTM. Our CBP +/- mice would be an excellent model for the study of the role of CBP in development and memory storage mechanisms. PMID- 9949199 TI - Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. AB - Huntington's disease (HD) is an inherited, neurodegenerative disorder caused by the expansion of a glutamine repeat in the N-terminus of the huntingtin protein. To gain insight into the pathogenesis of HD, we generated transgenic mice that express a cDNA encoding an N-terminal fragment (171 amino acids) of huntingtin with 82, 44 or 18 glutamines. Mice expressing relatively low steady-state levels of N171 huntingtin with 82 glutamine repeats (N171-82Q) develop behavioral abnormalities, including loss of coordination, tremors, hypokinesis and abnormal gait, before dying prematurely. In mice exhibiting these abnormalities, diffuse nuclear labeling, intranuclear inclusions and neuritic aggregates, all immunoreactive with an antibody to the N-terminus (amino acids 1-17) of huntingtin (AP194), were found in multiple populations of neurons. None of these behavioral or pathological phenotypes were seen in mice expressing N171-18Q. These findings are consistent with the idea that N-terminal fragments of huntingtin with a repeat expansion are toxic to neurons, and that N-terminal fragments are prone to form both intranuclear inclusions and neuritic aggregates. PMID- 9949200 TI - An alpha-tectorin gene defect causes a newly identified autosomal recessive form of sensorineural pre-lingual non-syndromic deafness, DFNB21. AB - In our efforts to identify new loci responsible for non-syndromic autosomal recessive forms of deafness, DFNB loci, we have pursued the analysis of large consanguineous affected families living in geographically isolated areas. Here, we report on the study of a Lebanese family comprising nine members presenting with a pre-lingual severe to profound sensorineural isolated form of deafness. Linkage analysis led to the characterization of a new locus, DFNB21, which was assigned to chromosome 11q23-25. Already mapped to this chromosomal region was TECTA. This gene encodes alpha-tectorin, a 2155 amino acid protein which is a component of the tectorial membrane. This gene recently has been shown to be responsible for a dominant form of deafness, DFNA8/12. Sequence analysis of the TECTA gene in the DFNB21-affected family revealed a G to A transition in the donor splice site (GT) of intron 9, predicted to lead to a truncated protein of 971 amino acids. This establishes that alpha-tectorin mutations can be responsible for both dominant and recessive forms of deafness. Comparison of the phenotype of the DFNB21 heterozygous carriers with that of DFNA8/12-affected individuals supports the hypothesis that the TECTA mutations which cause the dominant form of deafness have a dominant-negative effect. The present results provide genetic evidence for alpha-tectorin forming homo- or heteromeric structures. PMID- 9949201 TI - The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis. AB - Expansions of an intronic GAA repeat reduce the expression of frataxin and cause Friedreich's ataxia (FRDA), an autosomal recessive neurodegenerative disease. Frataxin is a mitochondrial protein, and disruption of a frataxin homolog in yeast results in increased sensitivity to oxidant stress, increased mitochondrial iron and respiration deficiency. These previous data support the hypothesis that FRDA is a disease of mitochondrial oxidative stress, a hypothesis we have tested in cultured cells from FRDA patients. FRDA fibroblasts were hypersensitive to iron stress and significantly more sensitive to hydrogen peroxide than controls. The iron chelator deferoxamine rescued FRDA fibroblasts more than controls from oxidant-induced death, consistent with a role for iron in the differential kinetics of death; however, mean mitochondrial iron content in FRDA fibroblasts was increased by only 40%. Treatment of cells with the intracellular Ca2+chelator BAPTA-AM rescued both FRDA fibroblasts and controls from oxidant-induced death. Treatment with apoptosis inhibitors rescued FRDA but not control fibroblasts from oxidant stress, and staurosporine-induced caspase 3 activity was higher in FRDA fibroblasts, consistent with the possibility that an apoptotic step upstream of caspase 3 is activated in FRDA fibroblasts. These results demonstrate that FRDA fibroblasts are sensitive to oxidant stress, and may be a useful model in which to elucidate the FRDA mechanism and therapeutic strategies. PMID- 9949202 TI - Allele-specific late replication and fragility of the most active common fragile site, FRA3B. AB - FRA3B at 3p14.2 is the most active of the common fragile sites in the human genome and is expressed when cells are exposed to the DNA replication inhibitor, aphidicolin. Several lines of evidence suggest that fragile sites are regions of late replication. To elucidate the relationship between the timing of replication across the FRA3B region and its corresponding fragility, we labeled cells with 5 bromo-2'-deoxyuridine (BrdU) and adopted an immunofluorescent procedure to visualize late replicating DNA (BrdU-substituted DNA) in metaphase chromosomes. We also chose 21 markers along the FRA3B region and analyzed the timing of replication using BrdU-labeled DNA from different stages of the cell cycle sorted by flow cytometry. Our results show that there are two distinct alleles that replicate at different stages in the cell cycle and that breaks/gaps preferentially occurred on the chromosome 3 with the late replication allele. These results provide direct evidence that allele-specific late replication is involved in the fragility of the most active common fragile site, FRA3B. PMID- 9949203 TI - Human cochlear expressed sequence tags provide insight into cochlear gene expression and identify candidate genes for deafness. AB - To identify candidate genes for human hearing disorders and to understand better human hearing at the molecular level, we constructed a human cochlear cDNA library. An aliquot of the unsubtracted cochlear library was contributed to the IMAGE Consortium at Lawrence Livermore National Laboratory for the generation of expressed sequence tags (ESTs) by the Merck/WashU EST project. Over 4000 ESTs were developed from the cochlear cDNA library and deposited in the GenBank EST database. Sequence clustering shows that the majority of clones are in low copy numbers, demonstrating the high complexity of the library. The sequences of 1388 cochlear ESTs (33%) match 517 known human genes. Among these are genes previously shown to cause both syndromic and non-syndromic hearing loss. A number of the cochlear ESTs show high homology to non-human genes, suggesting new gene family members or human homologs of animal genes. We also report the chromosomal map positions of 437 cochlear ESTs. These provide positional candidate genes for 18 different non-syndromic hearing disorders. A Human Cochlear EST Database web site (http://www.bwh.partners. org/pathology ) has been created to provide access to the cochlear clone data for gene discovery investigations. PMID- 9949204 TI - Single sperm analysis of the CAG repeats in the gene for dentatorubral pallidoluysian atrophy (DRPLA): the instability of the CAG repeats in the DRPLA gene is prominent among the CAG repeat diseases. AB - Dentatorubral-pallidoluysian atrophy (DRPLA) is known to show the most prominent genetic anticipation among CAG repeat diseases. To investigate the mechanism underlying the meiotic instability of expanded CAG repeats in the gene for DRPLA, we determined the CAG repeat sizes of 427 single sperm from two individuals with DRPLA. The mean variance of the change in the CAG repeat size in sperm from the DRPLA patients (288.0) was larger than any variances of the CAG repeat size in sperm from patients with Machado-Joseph disease (38. 5), Huntington's disease (69.0) and spinal and bulbar muscular atrophy (16.3), which is consistent with the clinical observation that the genetic anticipation on the paternal transmission of DRPLA is the most prominent among CAG repeat diseases. The variance of the change in CAG repeat size was significantly different between the two DRPLA patients (F-test, P < 0.0001). However, the segregation ratio of single sperm with an expanded allele to ones with a normal allele is not statistically different ( P = 0.161) from the expected 1:1 segregation ratio, and thus segregation distortion of expanded alleles in meiosis in male patients with DRPLA was not demonstrated. PMID- 9949205 TI - Methylation profiling of CpG islands in human breast cancer cells. AB - CpG island hypermethylation is known to be associated with gene silencing in cancer. This epigenetic event is generally accepted as a stochastic process in tumor cells resulting from aberrant DNA methyltransferase (DNA-MTase) activities. Specific patterns of CpG island methylation could result from clonal selection of cells having growth advantages due to silencing of associated tumor suppressor genes. Alternatively, methylation patterns may be determined by other, as yet unidentified factors. To explore further the underlying mechanisms, we developed a novel array-based method, called differential methylation hybridization (DMH), which allows a genome-wide screening of hypermethylated CpG islands in tumor cells. DMH was used to determine the methylation status of >276 CpG island loci in a group of breast cancer cell lines. Between 5 and 14% of these loci were hypermethylated extensively in these cells relative to a normal control. Pattern analysis of 30 positive loci by Southern hybridization indicated that CpG islands might differ in their susceptibility to hypermethylation. Loci exhibiting pre existing methylation in normal controls were more susceptible to de novo methylation in these cancer cells than loci without this condition. In addition, these cell lines exhibited different intrinsic abilities to methylate CpG islands not directly associated with methyltransferase activities. Our study provides evidence that, aside from random DNA-MTase action, additional cellular factors exist that govern aberrant methylation in breast cancer cells. PMID- 9949206 TI - Dystonia associated with mutation of the neuronal sodium channel Scn8a and identification of the modifier locus Scnm1 on mouse chromosome 3. AB - The mouse mutant medJ contains a splice site mutation in the neuronal sodium channel Scn8a that results in a very low level of expression. On a C57BL/6J genetic background, medJ homozygotes exhibit progressive paralysis and juvenile lethality. The C3H genetic background has an ameliorating effect, producing viable adults with a novel dystonic phenotype. The dystonic mice exhibit movement induced, sustained abnormal postures of the trunk and limbs. A dominant modifier locus responsible for the difference between strains was mapped to a 4.5 +/- 1.3 cM interval on mouse chromosome 3. Our findings establish a role for ion channels in dystonia and demonstrate the impact of genetic background on its severity and progression. This new model suggests that SCN8A on chromosome 12q13 and SCNM1 on chromosome 1p21-1q21 may contribute to human inherited dystonia. PMID- 9949207 TI - Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy. AB - The pathogenic mechanisms underlying myotonic dystrophy (DM), which results from a (CTG) n repeat expansion mutation in the 3'-untranslated region (3'-UTR) of the myotonic dystrophy protein kinase gene ( DMPK ), remain obscure. The multisystemic nature and variable expressivity of the symptoms are unlikely to be explained by a defect in this gene alone. However, the location of the DM associated (CTG) n repeat in the promoter region of SIX5, immediately downstream of DMPK, implicates it as a second candidate with a pathological role in DM. We hypothesize that dysfunction of SIX5, which is homologous to the Drosophila eye development gene sine oculis ( so ), is primarily responsible for the ophthalmic features of DM. We report an expression pattern for SIX5 in the normal adult eye that matches the sites of the ocular pathology in DM. SIX5 transcripts were detected in the adult corneal epithelium and endothelium, lens epithelium, ciliary body epithelia, cellular layers of the retina and the sclera. SIX5 expression was not detected in fetal eyes. We also report a restricted but partially overlapping expression pattern for DMPK transcripts and DMPK protein in normal fetal and adult eyes. DMPK transcripts were detected in fetal eyes and in adult conjunctival and corneal epithelia, uvea, cellular layers of the retina, optic nerve and in the sclera. DMPK protein was detected in the adult retina, conjunctival and ciliary body epithelia and in the smooth muscle of the ciliary body, pupillary sphincter and uveal blood vessels. We propose that the expression patterns of these two genes indicate their relative contribution to the ophthalmological dysfunction seen in DM. Furthermore, the expression of SIX5 and not DMPK in the adult lens implicates a role for SIX5 dysfunction in the development of adult onset cataracts, the most frequently occurring eye phenotype in DM. PMID- 9949208 TI - Circular dystrophin RNAs consisting of exons that were skipped by alternative splicing. AB - Exon skipping by alternative splicing and circular RNA formation are proposed to be interrelated events. Since multiple patterns of alternative splicing have been demonstrated in both the 5' and 3' regions of the dystrophin gene, the dystrophin transcript in skeletal muscle cells provides a model system in which this idea is tested. Nine circular RNAs that were expected to result from known exon skipping patterns in the 5' region of this gene were in fact identified, but three other circular RNAs expected to result from other known exon skipping reactions in this region could not be detected. The identification of two unexpected circular RNAs led to the discovery of two novel alternative splicing reactions. One circular RNA originating in the 3' region of the gene was identified but it lacked one small sized exon compared with the expected exon structure. Circular RNAs from the 5' region of the dystrophin gene could not be detected in Duchenne muscular dystrophy patients who have deletions of one or more exons in this segment of the gene, even though alternative splicing products were identified. These results showed that circular RNA formation is not necessarily linked to exon skipping and suggest that an undetermined factor regulates circular RNA formation. PMID- 9949209 TI - Genetic mapping of the copper toxicosis locus in Bedlington terriers to dog chromosome 10, in a region syntenic to human chromosome region 2p13-p16. AB - Abnormal hepatic copper accumulation is recognized as an inherited disorder in man, mouse, rat and dog. The major cause of hepatic copper accumulation in man is a dysfunctional ATP7B gene, causing Wilson disease (WD). Mutations in the ATP7B genes have also been demonstrated in mouse and rat. The ATP7B gene has been excluded in the much rarer human copper overload disease non-Indian childhood cirrhosis, indicating genetic heterogeneity. By investigating the common autosomal recessive copper toxicosis (CT) in Bedlington terriers, we have identified a new locus involved in progressive liver disease. We examined whether the WD gene ATP7B was also causative for CT by investigating the chromosomal co localization of ATP7B and C04107, using fluorescence in situ hybridization (FISH). C04107 is an anonymous microsatellite marker closely linked to CT. However, BAC clones containing ATP7B and C04107 mapped to the canine chromosome regions CFA22q11 and CFA10q26, respectively, demonstrating that WD cannot be homologous to CT. The copper transport genes CTR1 and CTR2 were also excluded as candidate genes for CT since they both mapped to canine chromosome region CFA11q22. 2-22.5. A transcribed sequence identified from the C04107-containing BAC was found to be homologous to a gene expressed from human chromosome 2p13 p16, a region devoid of any positional candidate genes. PMID- 9949210 TI - Germinal and somatic mutations in the PKD2 gene of renal cysts in autosomal dominant polycystic kidney disease. AB - Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in one of three genes: PKD1 on chromosome 16 accounts for approximately 85% of cases whereas PKD2 on chromosome 4 accounts for approximately 15%. Mutations in the PKD3 gene are rare. All patients present with similar clinical phenotypes, and the cardinal symptom is the formation of fluid-filled cysts in the kidneys. Previous work has provided data supporting the notion that cysts in ADPKD1 are focal in nature and form after loss of function of polycystin 1. This became evident by demonstrating that the normal PKD1 allele was inactivated somatically by loss of heterozygosity or by mutagenesis in a subset of renal or liver cysts examined. We show in this report, for the first time, multiple novel somatic mutations within the PKD2 gene of epithelial cells, in both kidneys of an ADPKD2 patient. From a total of 21 cysts examined, seven (33%) had the same C insertion within the inherited wild-type allele. In two other cysts, a nonsense mutation and a splice site AG deletion had occurred in a PKD2 allele that could not be identified as the inherited wild-type or mutant. We suggest that the autosomal dominant form of ADPKD2 occurs by a cellular recessive mechanism, supporting a two-hit model for cyst formation. PMID- 9949211 TI - Distinct mutation patterns of breast cancer-associated alleles of the HRAS1 minisatellite locus. AB - DNA sequence analysis of 130 alleles of the HRAS1 minisatellite has demonstrated that breast cancer-associated variants arise as a consequence of both replication errors and gene conversions. Unlike mutations at other variable number of tandem repeats (VNTRs), high-risk variants of the HRAS1 minisatellite do not demonstrate positional polarity. Instead, most mutations occur at three hotspots, with replication errors confined to one hotspot, gene conversions to a second and a mixed pattern of mutation at the third. DNA sequence analysis of 66 low-risk a1 alleles revealed no evidence for hypermutation. Therefore, while the HRAS1 minisatellite may serve as a reporter for a broad-based group of mutational mechanisms, these results are consistent with a direct pathogenetic contribution by high-risk alleles as the biological basis underlying cancer association of this VNTR. PMID- 9949212 TI - The Batten disease gene product (CLN3p) is a Golgi integral membrane protein. AB - Batten disease (juvenile neuronal ceroid lipofuscinosis) is a recessive neurodegenerative disorder of childhood. The gene, CLN3, was recently identified and found to encode a novel 438 amino acid protein of unknown function. In order to gain insight into the function of the Batten disease protein (CLN3p), we investigated its subcellular localization. Protein constructs incorporating CLN3p fused to the green fluorescence protein or an eight amino acid peptide tag were transiently expressed in fibroblasts, HeLa and COS-7 cells. A juxtanuclear, asymmetric localization pattern was observed that correlated with the Golgi apparatus in all three cell types. However, a proportion of transiently transfected cells exhibited a punctate vesicular distribution throughout the cytoplasm in addition to or without the Golgi localization. In order to account for localization patterns arising from intracellular protein transport disruption due to exaggerated overexpression in transiently transfected cells, we isolated a stably transfected cell line expressing only one copy of the CLN3 -GFP DNA construct. Fluorescence and biochemical analyses using this cell line demonstrated that CLN3p is an integral membrane protein that localizes primarily in the Golgi apparatus. The functional implications of this finding are discussed. PMID- 9949213 TI - The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities. AB - Transcribed, low-copy repeat elements are associated with the breakpoint regions of common deletions in Prader-Willi and Angelman syndromes. We report here the identification of the ancestral gene ( HERC2 ) and a family of duplicated, truncated copies that comprise these low-copy repeats. This gene encodes a highly conserved giant protein, HERC2, that is distantly related to p532 (HERC1), a guanine nucleotide exchange factor (GEF) implicated in vesicular trafficking. The mouse genome contains a single Herc2 locus, located in the jdf2 (juvenile development and fertility-2) interval of chromosome 7C. We have identified single nucleotide splice junction mutations in Herc2 in three independent N-ethyl-N nitrosourea-induced jdf2 mutant alleles, each leading to exon skipping with premature termination of translation and/or deletion of conserved amino acids. Therefore, mutations in Herc2 lead to the neuromuscular secretory vesicle and sperm acrosome defects, other developmental abnormalities and juvenile lethality of jdf2 mice. Combined, these findings suggest that HERC2 is an important gene encoding a GEF involved in protein trafficking and degradation pathways in the cell. PMID- 9949214 TI - Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein. AB - Previous studies have shown sequence similarity between a region of the autosomal dominant polycystic kidney disease (ADPKD) protein, polycystin-1 and a sea urchin sperm glycoprotein involved in fertilization, the receptor for egg jelly (suREJ). We have analysed sequence databases for novel genes encoding PKD/REJ-like proteins and found a significant region of homology to a large open reading frame in genomic sequence from human chromosome 22. Northern analysis showed that this is a functional gene [termed the polycystic kidney disease and receptor for egg jelly related gene ( PKDREJ )], but unlike polycystin-1, has a very restricted expression pattern; the approximately 8 kb transcript was found exclusively in testis, coincident with the timing of sperm maturation. The PKDREJ transcript was cloned by screening a testis cDNA library and RT-PCR which revealed a 7660 bp mRNA terminating with a 900 bp 3'UTR and a polyA tail. Comparison with genomic sequence showed that PKDREJ is intronless; sequencing the mouse orthologue revealed a similar structure. The predicted human PKDREJ protein has 2253 amino acids (calculated molecular mass 255 kDa) and sequence similarity over approximately 2000 amino acids with polycystin-1, corresponding to the predicted membrane associated region and the area of homology ( approximately 1000 amino acids) with the suREJ protein (the REJ module). The suREJ protein binds the glycoprotein coat of the egg (egg jelly), triggering the acrosome reaction, which transforms the sperm into a fusogenic cell. The sequence similarity and expression pattern suggests that PKDREJ is a mammalian equivalent of the suREJ protein and therefore may have a central role in human fertilization. PMID- 9949215 TI - Editorial: The changing landscape of pediatrics. PMID- 9949216 TI - Basement membranes in development. PMID- 9949217 TI - Cervical ribs: useful marker of monosomy X in fetal hydrops. AB - Cervical ribs were observed in six hydropic fetuses with 45X karyotype. To test the usefulness of this observation in the macerated hydropic fetus where chromosome culture is problematic, a group of 36 hydropic fetuses was examined. Cases were chosen to include fetuses with several karyotypic and pathological abnormalities known to be associated with fetal hydrops. Whole-body anteroposterior radiographs were evaluated without knowledge of the fetal karyotype or pathological findings. Twenty-five fetuses had an abnormal karyotype, seven had a normal karyotype and in four culture failed. In the last group, the number of X, 21 and 18 chromosomes per nucleus was estimated using FISH. Radiographic analysis demonstrated that among the 16 fetuses with 45,X karyotype or a single copy of X and female phenotype, 12 had a pair of cervical ribs. Three other fetuses had a single cervical rib. Only one fetus had no cervical ribs. The last fetus had tubular hypoplasia of the aortic arch and persistent mesocolon. Twelve of the sixteen 45,X fetuses had tubular hypoplasia of the aortic arch. Seven had other cardiovascular anomalies, five had renal anomalies, and five had anomalies of intestinal rotation. Cervical rib appears to be more common than other frequently recorded associations of 45,X. It is a useful and easily demonstrated mark in the evaluation of the macerated hydropic fetus. PMID- 9949218 TI - Abnormalities in central nervous system development in osteogenesis imperfecta type II. AB - Osteogenesis imperfecta (OI) type II is a perinatally lethal condition resulting from mutations in type I collagen genes. In addition to characteristic skeletal anomalies, OI type II has recently been shown to be associated with neuropathological alterations, specifically perivenous microcalcifications, and impaired neuroblast migration. In light of these findings, and because type I collagen promotes neuritic maturation both in vitro and in vivo, we sought to determine if additional central nervous system (CNS) developmental anomalies could be found in previously autopsied OI type II cases, and if specific abnormalities correlate with OI subtypes. We retrospectively studied brains of nine patients diagnosed with OI. Of these, seven were OI type II: five were OI type IIA, one was type IIB, and one was type IIC. One OI type I specimen and one OI type III brain were included for comparison, as well as five controls. The IIC brain showed hippocampal malrotation, agyria, abnormal neuronal lamination, diffuse hemorrhage, and periventricular leukomalacia (PVL). The IIB brain had white matter gliosis, PVL, and perivascular calcifications, but was normally developed. Of the five type IIA brains, two showed migrational defects with coexisting PVL and gliosis, two were normally developed with similar white matter injuries, and one was grossly normal. These findings support the contention that collagen mutations might negatively impact CNS development. PMID- 9949219 TI - Correlation of prenatal ultrasound diagnosis and pathologic findings in fetal anomalies. AB - This retrospective study compared the prenatal ultrasound (US) diagnosis with autopsy findings in 61 intact fetuses following induced abortion and 36 fragmented fetuses from dilatation and evacuation (D&E). In intact fetuses, complete agreement between US diagnosis and autopsy findings was achieved in 65.6% of cases in the central nervous system (CNS) and 47.5% in other somatic organ systems (SOS). There were major differences between US and autopsy findings involving the CNS in 6.5% of cases and SOS in 27.9%. Correlation was better for evaluation of renal anomalies (complete agreement in 63.6% of 11 suspected cases, 2 false-positive and no false-negative cases) than congenital heart disease (complete agreement in 27.3% of 11 suspected cases, 5 false-positive and 3 false negative cases). In D&E specimens, a prenatal diagnosis of neural tube defect (NTD) was confirmed in 90% of cases. However, due to fragmentation of fetal parts, the US diagnosis in the CNS could not be confirmed totally (69.4%) or partially (2.8%) in fetuses with chromosomal abnormalities (ChA) or multiple congenital anomalies (MCA). Nonetheless, the US diagnosis of SOS was confirmed in six cases on D&E, including Meckel-Gruber syndrome, cystic hygroma, renal agenesis with contralateral renal dysplasia, cardiac defect, fetal hydrops, and tracheal atresia. Our results show that a thorough autopsy of an intact fetus after abortion is necessary to confirm prenatal diagnosis and allow proper management and counseling. The pathologic examination of D&E specimens can reliably confirm the US diagnosis of NTD, but it is very limited in identifying other fetal anomalies. PMID- 9949220 TI - Effects of cocaine on the placenta. AB - Adverse perinatal outcomes of gravidas using cocaine is well documented, but the effects on the placenta have been difficult to elucidate due to confounding factors such as concurrent use of other drugs. This study compares pathologic findings of 26 placentas from women who used only cocaine during pregnancy with findings from 26 controls. All women were from a similar socioeconomic class and were controlled for gestational age and tobacco use. None of the cocaine placentas were from women whose toxicology screens were positive for drugs other than cocaine. In the 26 cocaine placentas, there was 1 infarct, 3 chronic villitis, and 1 segmental fibrosis, with none present in the controls. In the control group, there was 1 decidual vasculopathy and 1 thrombus in a maternal vessel, but none were in the cocaine placentas. Each group had 1 thrombus in a fetal vessel. The study group showed 6 cases of chorioamnionitis and 1 funisitis; the control group had 10 and 4 cases, respectively. None of the above or seven other features showed a statistically significant difference between the cases and controls. Cocaine is a potent vasoconstrictive agent that blocks re-uptake of norepinephrine at the adrenergic nerve terminals. Our study suggests that cocaine does not cause an increased incidence of any of the 15 clearly recognizable placental features examined. PMID- 9949221 TI - Immunohistochemical localization of erythropoietin and its receptor in the developing human brain. AB - We have previously shown erythropoietin (Epo) and its receptor (Epo-R) to be present in the fetal human central nervous system (CNS), and Epo to be present in the spinal fluid of normal preterm and term infants. To investigate the cellular specificities and developmental patterns of expression of these polypeptides in the human brain-areas that have not been well researched-we designed the following study. Human brains ranging in maturity from 5 weeks post-conception to adult were preserved at the time of elective abortion, surgical removal (tubal pregnancy, or removal for temporal lobe epilepsy), or autopsy. Immunohistochemistry was used to localize Epo and Epo-R reactivity in brains of different stages of development. Astrocytes, neurons, and microglia were identified in sequential tissue sections by specific antibodies. At 5 to 6 weeks post-conception, both Epo and Epo-R localized to cells in the periventricular germinal zone. At 10 weeks post-conception, Epo immunoreactivity was present throughout the cortical wall, with the most intense immunoreactivity present in the ventricular and subventricular zones. Epo-R, in contrast, was localized primarily to the subventricular zone, with little staining evident in the ventricular zone. In late fetal brains, Epo-R reactivity was most prominent in astrocytic cells, although modest reactivity was observed in certain neuron populations. In contrast, Epo staining localized primarily to neurons in fetal brains, although a subpopulation of astrocytes was also immunoreactive. In postnatal brains, both astrocyte and neuron populations were immunoreactive with antibodies to Epo-R and Epo. From these results it is clear that Epo and its receptor are present in the developing human brain as early as 5 weeks post conception, and each protein shows a specific distribution that changes with development. We speculate that Epo is important in neurodevelopment, and that it also plays a role in brain homeostasis later in life, functioning in an autocrine or paracrine manner. PMID- 9949222 TI - Malignant peripheral nerve sheath tumor of bone in children and adolescents. AB - Malignant peripheral nerve sheath tumor (MPNST) of bone is a rare entity. We have examined three lesions that fit standard histopathologic criteria for MPNST of soft tissues but that arose in the skeleton of three children aged 6 to 13 years. None was affected by neurofibromatosis 1 (NF1). Histologic features typical of MPNST included spindle cells with comma-shaped nuclei, tactoid bodies, nuclear palisading, hyaline bands, and schwannoma-like and curlicue foci. Epithelioid foci were seen in two cases, and heterologous differentiation in one. Immunohistochemistry revealed positivity for S-100 (1 positive/3 tested), vimentin (3/3), glial fibrillary acidic protein (2/3), CD34 (1/1), and CD68 (1/2). Studies for CD99 (0/3), epithelial membrane antigen (0/3), cytokeratin (0/3), CD57 (0/3), and HMB-45 (0/2) were negative. Ultrastructural findings in one of two cases examined included interlacing, attenuated cytoplasmic processes, microtubules, and rare dense-core granules. We conclude that MPNST may arise as a primary bone neoplasm in children without NF1. PMID- 9949223 TI - Cerebral mantle thickness: a measurement useful in anatomic diagnosis of fetal ventriculomegaly. AB - The ultrasonographic diagnosis of cerebral ventriculomegaly carries grave implications, in that affected fetuses may suffer abnormal postnatal development or therapeutic abortion. It is important for pathologists to corroborate the clinical diagnosis, but because diagnostic methodologies and criteria differ so radically, this can be problematic. The clinical diagnosis is made primarily by serial ultrasound examinations of the cerebral ventricles, spaces that can be altered postmortem, particularly when the brain is autolysed or deformed artifactually. We therefore sought to learn if examination of tissue, rather than spaces, can identify accurately those fetuses diagnosed with cerebral ventriculomegaly by prenatal ultrasound. The thickness of the cerebral mantle was obtained in 100 control fetuses aged 14 to 26 postmenstrual weeks. Statistical analysis revealed significant correlation of cerebral mantle thickness with crown rump length, foot length, and head circumference. Twenty fetuses diagnosed with ventriculomegaly showed mantle thicknesses that were less than the control mean. In a few cases, mantle thickness fell between the mean and -1 SD; in several others, thickness was diminished by -1 SD to -2 SD; in one-half of cases, mantle thickness was 2 SDs or more below the expected mean. Head circumference was within 2 SDs of the control mean in most cases, and increased beyond 2 SDs in only two cases. Head circumference is an unreliable indicator of ventriculomegaly in the midgestational fetus. By contrast, cerebral mantle thickness is a simple and useful way of corroborating ultrasonographic diagnoses at autopsy and may also prove useful in clinical settings. PMID- 9949224 TI - Unusual case of tracheal agenesis. AB - We describe the clinical presentation and pathological features of an unusual case of tracheal agenesis. The axial derivatives of the primitive foregut between the larynx and stomach were represented by a single structure featuring sequential segmentation into regions showing exclusively tracheal or esophageal differentiation in a pattern that is not easily classified by existing nosologic systems nor explained by the conventional hypothesis of dysontogenesis. PMID- 9949225 TI - Seckel-like syndrome in three siblings. AB - Seckel syndrome has been described as the prototype of the primordial bird-headed type of dwarfism. Since Seckel originally defined the disorder, less than 60 cases have been reported. In addition to the characteristic craniofacial dysmorphism and skeletal defects, abnormalities have been described in the cardiovascular, hematopoietic, endocrine, and central nervous systems. This pleiotropy has implied genetic heterogeneity and prompted reviews of previously reported cases of Seckel syndrome. As a result, the characteristic diagnostic features of Seckel syndrome have been highly debated. Although deletions in chromosome 2q have been described, to date, no genetic defect has been defined. We report three cases of Seckel-like syndrome in siblings from nonconsanguinous Caucasian parents. In addition to the typical Seckel phenotypic features, all three cases were characterized by severe hydrocephalus. We review the literature and propose that there is a spectrum of Seckel conditions that share some common key features, but also demonstrate a wide range of phenotypic features. PMID- 9949227 TI - ABSTRACTS: abstracts from the interim meeting of the society for pediatric pathology, toronto, canada, september 18, 1998 PMID- 9949226 TI - Variant EWS-WT1 chimeric product in the desmoplastic small round cell tumor. AB - Chromosome translocations found in neoplasms often result in the creation of hybrid genes encoding chimeric proteins. Desmoplastic small round cell tumor (DSRCT) is a recently described aggressive malignancy associated with a unique chromosomal translocation t(11;22)(p13;q12). This translocation has recently been characterized, revealing the rearrangement and fusion of the WT1 gene on chromosome 11 to the EWS gene on chromosome 22. Fusion of these two genes results in the production of a putative oncogenic protein composed of the zinc finger DNA binding domains of WT1 linked to the potential transcriptional regulatory domains of EWS. The typical chimeric transcript consists of the first 7 exons of EWS and the last 3 exons of WT1. We report here the first case of DSRCT with a variant EWS-WT1 chimeric product that includes 9 exons of EWS and 3 exons of WT1. PMID- 9949228 TI - Tuberous sclerosis. PMID- 9949230 TI - [Presinilin 1 gene polymorphism and Alzheimer's disease in Chinese]. AB - OBJECTIVE: To detect the relationship between Presinilin 1(PS1) intronic polymorphism and Alzheimer's disease(AD) in Chinese. METHODS: PS1 intronic polymorphism was genotyped in 58 early-onset AD cases(EOAD), 65 late-onset AD cases (LOAD) and 157 age-matched controls by using PCR methods and RFLP typing. Then the association between PS1 polymorphism and AD was analyzed. RESULTS: (1) In EOAD cases, the frequency of allele 1 increased and the frequencies of allele 2 and genotype 2/2 decreased markedly, but in LOAD cases, no differences were observed. (2) EOAD was significantly associated with allele 1 (RR=2.29), P< 0.05), allele 2 (RR=0.44) and genotype 2/2(RR=0.23, P<0.05) of PS1 polymorphism, while LOAD showed no association with PS1 polymorphism. (3)PS1 polymorphism was associated with AD predominantly in non-ApoE epsilon4, female, early-onset cases. CONCLUSION: PS1 polymorphism was only associated with EOAD in Chinese, and this may be influenced by age of onset and sex. PMID- 9949231 TI - [Linkage studies of a familial spastic paraplegia pedigree from Tibet]. AB - OBJECTIVE: To study the location of disease-related gene in a hereditary spastic paraplegia family with autosomal dominant inheritance in Tibet. METHODS: The AD HSP family in Tibet was analyzed by linkage studies using 9 highly polymorphic microsatellite DNA markers at three chromosomal regions. RESULTS: The maxium Lod- Score of D14S264 was 0.5163(theta=0.05); of D14S75, 2. 1072 (theta=0);+D14S69, 0.2840 (theta=0.10); of D14S266, 0.9311 (theta=0);of D14S66, 0.7991(theta=0);OF GABRB3, 0(theta =0.40);of D15S128, 0(theta=0.40); of D2S2255, 0 (theta=0.40);and of D2S2347,0(theta=0.40). CONCLUSION: In this Tibetian family, the disease related gene is linked to D14S75 locus of SPG3 region. PMID- 9949232 TI - [Identification of mutations in the phenylalanine hydroxylase gene and exon 5 novel mutation Y166X(C-->G) in Yunnan]. AB - OBJECTIVE: To identify the mutations of the phenylalanine hydroxylase gene in Yunnan so as to enhance the gene diagnosis of classical phenylketonuria (PKU) in that south-western province of China. METHODS: Exons 4,5,6,7,10,11 and 12 of the phenylalanine hydroxylase(PAH) were analyzed in 13/14 children affected with classical PKU from Yunnan by using PCR-single strand conformation polymorphism (PCR-SSCP),PCR-ASO dot blot hybridization,allele specific polymerase chain reaction(ASPCR) and PCR-direct sequencing. RESULTS: Five missense mutations, i.e. R243Q. (5/26), Y204C(3/28), G247V(1/26),R413P(2/28) and T418P(1/28);three nonsense mutations,i.e. Y166X(C-->G)(2/26),W326X(1/28) and Y356X(2/26);and one silent mutation(V399V)(2/26) were identified. The nonsense mutation Y166X(C-->G) should be a novel mutation as compared with the PAH Mutation Database. CONCLUSION: Five kinds of popular PAH gene mutation (R243Q,Y204C,V399V,Y356X and R413P) identified in the people of Yunnan are similar to those in the northern people, but such characteristic is different from that in the southern people. This finding will enhance the efficacy in gene diagnosis of PKU and will be of reference value for studies of population and regional difference in the pattern of PAH mutation distribution. PMID- 9949233 TI - [Inhibition of Bcl-2 expression in HL60 cells by incubation with antisense phosphorothioate oligodeoxynucleotides]. AB - OBJECTIVE: To observe whether the expression of Bcl-2 mRNA and protein in HL60 cells could be decreased by incubation with antisense phosphorothioate oligodeoxnucleotides (ASPO) at different concentrations (5micromol/L,10micromol/L,and 20micromol/L). METHODS: The expressions of Bcl-2 protein and mRNA in HL60 cells were individually determined by immunocytochemistry, flow cytometry and RT-PCR. RESULTS: In the presence of ASPO, the levels of Bcl-2 mRNA and protein could be decreased. The inhibitory effect appeared in the first 24 hours of incubation and became intense as the concentration increased and the time prolonged,but it abated after 72 hours of incubation. Inhibition was not noted in the presence of sense phosphorothioate oligodeoxynucleotides(SPO). CONCLUSION: The data suggested that ASPO could inhibit the expression of Bcl-2 mRNA and protein in HL60 cells and the inhibitory effect depended on the specific sequences, the concentration and the time of incubation, but it could not last very long. PMID- 9949234 TI - [Mutations of the fibroblast growth factor receptor 3 gene in achondroplasia]. AB - OBJECTIVE: To evaluate whether mutation in the exon 10 of the fibroblast growth factor receptor 3(FGFR3) gene in common in Chinese patients with achondroplasia. METHODS: Genomic DNA from seven sporadic cases of achondroplasia was studied by using PCR-SSCP and restriction enzymes. RESULTS: All patients carried the same glycine-to-arginine mutation at codon 380(G380R) of the transmembrane domain of FGFR3. CONCLUSION: The results suggest that the G380R mutation of FGFR3 is also a frequent mutation causing achondroplasia in Chinese. Detecting FGFR 3 gene mutation with PCR-SSCP and restriction enzymes analysis is a convenient, rapid and reliable molecular diagnostic assay for prenatal and early diagnosis of achondroplasia. PMID- 9949235 TI - [Long-term follow-up of combined therapy with large-dose zinc sulfate and low dose penicillamine in children with hepatolenticular degeneration]. AB - OBJECTIVE: To summarize the long-term effect of combined treatment with large dose zinc sulfate and low-dose penicillamine in children with hepatolenticular degeneration (HLD). METHODS: The patients who had symptoms were treated with large-dose zinc sulfate (100-150mg, <6yr; 150-200mg, 6-8yr; 200-300mg, 9-10yr; 300mg,>10yr; 3 times a day) in addition to low-dose penicillamine(8-10mg/kg/d) at the beginning of treatment. Zinc sulfate alone was given to the presymptomatic patients and it was used as maintenance therapy when clinical improvement was obtained. 31 children were followed up for 4-11 years. RESULTS: In 3 presymptomatic patients, no clinical abnormalities were found. Among 28 patients with symptoms, 23 patients (82%) had their symptoms and signs subsided or much improved, 2 patients(7%) remained unchanged, and 3(11%) died. Blood concentrations of copper were persistently lower than normal. Urine copper excretion of 24 hours was significantly lower than that before the combined therapy in all patients, and it became normal in 5 cases(16%) after 6 months of treatment, and in 26 cases(84%) after 1-2 years of treatment. Higher blood concentrations of zinc were found in 20 cases(65%), and higher urine zinc excretion was noted in 25 cases(81%) once or more times during the therapy. CONCLUSION: Combined therapy of large-dose zinc sulfate and low-dose penicillamine is an effective, safe and cheap treatment for children with HLD. PMID- 9949236 TI - [Pathogenic gene linkage analysis and hemopoietic characteristics in a kindred with sideroblastic anemia]. AB - OBJECTIVE: Analysis of pathogenic gene linkage and hemopoietic characteristics in a kindred with sideroblastic anemia. METHODS: PCR amplification of the microsatellites DXS991,DXS1199 in chromosome Xp11.22 linked gene ALAS2 and of the microsatellite DXS1226 in Xp22. 13 linked another irrelevant gene and analysis of gene linkage in a kindred with 2 patients and 7 normal persons. The bone marrow hemopoietic cells from 2 patients were cultured in condition culture matrix with various cytokines added in and the CFU-E, CFU-GM and CFU-Meg formations were observed at different times. RESULTS: The kindred study revealed that pathogenic gene linked with DXS991 and DXS1199 but did not link with DXS1226.Hemopoietic cell culture showed that erythroid colonies of the two patients grew more vigorously than controls and they could grew in the absence of Epo except in common condition matrix. The erythroid colonies withered after a week and were smaller than the controls after 13 days. CONCLUSION: The kindred is subject to an X-linked sideroblastic anemia(XLSA) with the pathogenic gene ALAS2 involved. In XLSA,the function of stem cells is primarily normal before erythropoiesis, then the erythroid progenitors become dysplasia. PMID- 9949237 TI - [Genetic polymorphisms of CYP1A1 and susceptibility of lung cancer]. AB - OBJECTIVE: To assess the possible association between the polymorphisms of CYP1A1 and the susceptibility of lung cancer so as to provide clues for genetic markers of lung cancer. METHODS: CYP1A1 rare genotypes MspI C and VV were detected with the methods of PCR-RFLP and ASA in a case-control study including 59 cases of lung cancer, 59 hospital controls and 73 healthy controls. RESULTS: The frequencies of rare genotypes C and VV of the lung cancer cases were not significantly different from those of the controls, though the frequency of C(25.4%) of the lung cancer cases was higher than that (16.5%) of the controls. However, in the non-smoking group with genotype(C),the risk of lung cancers was 2.43-2.91 times greater than that of the controls. Heterozygote B was overpresented in healthy controls (61.6%),compared to that of lung cancer cases(37.3%), P <0.01,odds ratio 0.37 (95% confidence interval 0.17-0.80). CONCLUSION: Genotype C may be one of the susceptibly genetic markers of lung cancer in the non-smoking population. The risk of lung cancer can be decreased in persons with heterozygote. PMID- 9949238 TI - [Detection of insertion/deletion polymorphism of angiotensin converting enzyme gene in preeclampsia]. AB - OBJECTIVE: To establish a method for sensitive, specific and rapid detection of the angiotensin converting enzyme(ACE) genotypes and to study the relationship between the ACE gene polymorphism and preeclampsia. METHODS: Sixty patients with preeclampsia and 76 normal pregnant women as controls were investigated. A pair of primers, for the intron 16 of ACE gene was designed. A sensitive and specific method for detecting the ACE polymorphism of the insertion/deletion was established. Determined by polymerase chain reaction (PCR),a 490bp(I) and 190bp(D) PCR product was identified,corresponding to the PCR amplification of the allele with or without the insertion. RESULTS: The subjects were classified, according to the presence or absence of a 287bp insertion in intron 16 of the ACE gene, as II, DD, or heterozygotes for deletion/insertion (DI). The frequency of allele gene (0.75) and the percentage of the ACE DD genotype (65%) in the preeclampsia group were significantly higher as compared with the frequency 10.308 and the percentage (10.5%) in the control group respectively. CONCLUSION: Genotype II of ACE is a marker for reduced risk for preeclampsia and DD is a risk gene. PMID- 9949239 TI - [A DNA probe suitable for the detection of chromosome 21 copy number in human interphase nuclei by fluorescence in situ hybridization]. AB - OBJECTIVE: To prepare DNA probe which can be used to accurately detect chromosome 21 copy number in human interphase nuclei by fluorescence in situ hybridization (FISH). METHODS: A probe was produced by universal primer PCR from YAC clone 881D2 and characterized by FISH to metaphases and interphase nuclei of peripheral lymphocytes from 8 normal individuals and 5 patients suffering from trisomy 21. RESULTS: A DNA probe was produced and its characteristics were :(1) Most of the probes ranged in size from 350bp to 750bp; (2) The hybridization signals of the probes were located near centromere on long arm of human chromosome 21; (3) In 1524 metaphases scored, about 99.95% of hybridization signals were located on chromosome 21; (4) The signals were very bright and recognizable easily in both metaphases and interphases nuclei; (5) The expected copy number of chromosome 21 was detected by FISH with the probe in more than 98.40% of interphase nuclei and 99.60% of metaphases. CONCLUSION: The DNA probe reported here is suitable for the detection of chromosome 21 copy number in interphase nuclei and for the study of segregation of chromosome 21 during mitoses of human lymphocytes in culture. PMID- 9949240 TI - [Rapid detection of an HPFH deletion by PCR amplification with three primers bridging the breakpoint]. AB - OBJECTIVE: To establish a rapid and reliable PCR method for detecting a deletional hereditary persistence of fetal hemoglobin (HPFH) found in Chinese. METHODS: Based on some novel DNA sequences across the 3'breakpoint of a HPFH deletion observed in our laboratory, we designed a PCR amplification with three primers bridging the breakpoint. In this system, oligonucleotide primers have been chosen which allow specific identification of both normal and deletional chromosomes under identical condition in either the same or parallel PCR reactions. RESULTS: The expected two specific amplification bands were produced; one was 565bp in length and stood for the normal alleles,the other,37bp in length represented the mutant alleles of beta-globin gene cluster. This duplex system could directly genotype DNA samples bearing this type of HPFH deletion. CONCLUSION: This rapid and inexpensive method could be used as a routine method in the molecular screening of carriers and for the prenatal diagnosis of this disease. PMID- 9949241 TI - [Isolating the ends of yeast artificial chromosome by inverse polymerase chain reaction]. AB - OBJECTIVE: To establish a highly efficient method for isolating yeast artificial chromosome(YAC) ends. METHODS: Based on the sequence of TAC vector, the frequent cutting enzymes were used to cleave within the vector and the genomic insert to generate relatively small fragments,which were ligated and subsequently amplified using vector primers that are in inverse orientation. The PCR products were purified and sequenced. RESULTS 8 YAC termini were isolated from YAC 776E2,964C5,11D8 and 8D1. CONCLUSION: The results suggest that inverse PCR be an efficient method for isolating YAC termini. PMID- 9949242 TI - Posttraumatic headache: caveats and controversies. AB - Posttraumatic headache (PTHA) although quite common, is still poorly understood in many ways. This article will provide opinions, insights, and analysis of some of the ongoing controversies and issues in PTHA assessment and treatment. Topics germane to nomenclature problems, classification criteria, paradoxes regarding headache incidence relative to injury severity, lack of identified medical specialty for referral of patients with PTHA, medicolegal issues, PTHA perpetuating factors, impairment and disability assessment, and research needs are addressed. Recommendations for addressing some of the concerns brought up in this commentary will be focused on in the article's concluding comments. These caveats and controversies will hopefully serve to familiarize readers with some of the inherent difficulties in PTHA management and treatment. PMID- 9949243 TI - Epidemiology and pathogenesis of posttraumatic headache. AB - This article presents an overview of the epidemiology and pathophysiology of posttraumatic headache. It reviews definitions of mild head injury (MHI), mild traumatic brain injury (MTBI), and concussion, and discusses the confusion that often occurs with these terms. Headache types and their pathophysiology are examined in detail. Just as the exact pathophysiology is unknown for migraine and other types of headache, the exact pathophysiology of headache after trauma is also still unknown in many cases. Possible connections between head or neck injuries and headache are reviewed, as well as hypothesized neurochemical changes that may occur in both migraine and traumatic brain injury (TBI). Psychological and legal factors are also considered. PMID- 9949244 TI - Clinical assessment of posttraumatic headaches. AB - The evaluation of the person with posttraumatic headache remains a difficult clinical task. The rehabilitation clinician seeing the person with posttraumatic headache may encounter a large spectrum of potential etiologies for cephalgia. We believe an ordered approach to the history, physical, and laboratory examination may lead to a more accurate and focused diagnosis in some cases. In an attempt to provide a directed approach to posttraumatic headaches, this discussion is divided into extracranial and intracranial sources. A brief table guide to the etiology of pain by site is presented, and the key eight steps of examination are reviewed. PMID- 9949245 TI - Medical management of posttraumatic headaches: pharmacological and physical treatment. AB - Posttraumatic headache can be a very difficult syndrome to manage, especially if chronic. As with most other types of headache, medications are the primary treatment modality, although there is very limited evidence-based data to support any given approach. A number of physical interventions also are available to be used in conjunction with medication, particularly for headaches with a musculoskeletal component. This article will review the general principles of pharmacological treatment for headache and the physical approach to treatment of headaches and head and facial pain. The major categories of medications commonly used for treatment of many varieties of headache will be discussed. In addition, the problems encountered in diagnosing and treating chronic daily headache and analgesic rebound headache are addressed. The approach to treatment of such syndromes as myofascial pain, cervico-zygapophyseal joint pain, neuritic pain, and craniocervical somatic pain are outlined. PMID- 9949246 TI - Posttraumatic headache: neuropsychological and psychological effects and treatment implications. AB - Posttraumatic headache (PTHA) is a frequent occurrence following trauma to the head, brain, and/or neck. Estimates of persistence for 6 months are as high as 44%. Review of available studies examining the effect of headache on neuropsychological test findings reveals that chronic headache pain, and chronic pain generally, exerts a significant and negative effect that poses a challenge to differential diagnostic efforts in the evaluation of mild brain injury. Given that PTHA is the most common postconcussive symptom and most frequent type of posttraumatic pain associated with mild traumatic brain injury (TBI), it follows that resolution of the postconcussion syndrome, and successful posttraumatic adaptation, may frequently rely on success in coping with PTHA symptomatology. Viewing PTHA from a biopsychosocial perspective, a general outline is offered for improving both assessment and treatment of PTHA. In addition, the most promising psychology-based treatment interventions are reviewed. PMID- 9949247 TI - Headache level during neuropsychological testing and test performance in patients with chronic posttraumatic headache. AB - This study addresses (1) the relationship between headache presence/intensity at time of testing and neurocognitive performance, and (2) the probability that testing triggers or intensifies pain. Subjects were 125 patients with chronic posttraumatic headache (mean = 2.67 years post injury) who completed a 4-hour test battery emphasizing memory. Comparisons of 34 individual tests/subtests and the five Wechsler Memory Scale-Revised (WMS-R) indices of relative memory impairment for 73 patients with no headache or mild headache versus 52 patients with moderate to severe pain revealed no significant differences. Testing intensified existing headaches for 55% but triggered headache for only 1 of 20 (5%; P =.00003). Results support the validity of neuropsychological test performance regardless of pain level, although testing can be painful. PMID- 9949249 TI - The Wireless Communications and Public Safety Act of 1998. PMID- 9949248 TI - Posttraumatic tension pneumocephalus. AB - This case presentation will review tension pneumocephalus as a rare etiology of delayed posttraumatic headache (PTHA). It demonstrates that clinicians must be aware of even the uncommon causes of PTHA if appropriate diagnostic assessment and treatment are to be rendered. The case involves a 26-year-old right-handed white male who was 4 years post severe traumatic brain injury with facial fractures and an initial Glasgow Coma Scale score of 5. The patient's main postinjury functional impairments were cognitive-behavioral dysfunction, dysmetria, left hemiparesis, and posttraumatic epilepsy. Approximately 3 years post injury, the patient started to have complaints of right unilateral frontal headache. This complaint was addressed conservatively by several treating physicians. Due to the progressive nature of the patient's complaints, a second opinion was obtained with the author. On assessment, the patient complained of unilateral right headache and described the pain as making him feel as if his head was going to "bust open." A computed tomography (CT) scan showed findings consistent with a tension pneumocephalus. The patient was referred to neurosurgery, at which time the tension pneumocephalus was evacuated and a dural leak, felt to be responsible for the condition, patched. The patient's headache complaints resolved postoperatively. Clinicians should be aware of uncommon conditions that may be present in patients presenting with late PTHA, particularly conditions such as tension pneumocephalus which may have a significant clinical morbidity. PMID- 9949250 TI - A view from the inside: the diving bell and the butterfly. PMID- 9949251 TI - Reliability of the Agitated Behavior Scale. AB - OBJECTIVE: The objective of this study was to investigate the interrater reliability of the Agitated Behavior Scale. DESIGN: Ratings made by research assistants and nursing staff were compared. PARTICIPANTS AND SETTING: Forty-five persons with brain injury and 23 persons with progressive dementia were studied at an acute rehabilitation unit and a long-term-care facility. RESULTS: Ratings of persons with brain injury by research assistants yielded a correlation coefficient for the Total score of.920. The correlation coefficients for the factors Disinhibition, Aggression, and Lability were.902,.909, and.726, respectively. Lower coefficients were obtained when the ratings of the research assistants and nursing staff were correlated; these ranged from.364 to.604. The ratings by research assistants of long-term-care facility residents yielded coefficients ranging from.860 to.906 for the Total and factor scores. CONCLUSION: This study shows that the Agitated Behavior Scale is a reliable instrument for measuring agitation in persons with traumatic brain injury, as well as with long term-care facility residents experiencing dementia. PMID- 9949252 TI - Management of spasticity in children: part 1: chemical denervation. PMID- 9949253 TI - Health care is too important to all of us to be treated as a commercial commodity. PMID- 9949254 TI - Ion channels, cell volume, and apoptotic cell death. PMID- 9949255 TI - Rat renal expression of mRNA coding for aldose reductase and sorbitol dehydrogenase and its osmotic regulation in inner medullary collecting duct cells. AB - Sorbitol plays an important role in the osmoregulation of several renal cell types, especially the inner medullary collecting duct (IMCD) cells. Very little information is available concerning the expression of the enzymes of sorbitol metabolism (aldose reductase (AR) and sorbitol dehydrogenase (SDH)) on the RNA level under different osmotic conditions. We employed a RT-PCR-based strategy to investigate the regulation of mRNA coding for AR and SDH. For AR two primers (derived from the sequence of the rat eye lens) were chosen which amplify a 668 bp product. For SDH (considering the sequence of rat liver) three primers were chosen, amplifying a 367- and a 1, 068-bp fragment. Digestion with restriction enzymes and sequencing of the products clearly indicate that the specific mRNA of AR and SDH was amplified. By relative quantitative determination of the amplification products a more than 4-fold increase in mRNA for AR in IMCD cells was observed within 24 h after increasing the extracellular osmolarity from 600 to 900 mosm/l. Decreasing the osmolarity from 600 to 300 mosm/l resulted in a reduction in the mRNA level by 70%. The complete adaptation of the AR activity needed 3 (increasing osmolarity) and 6 days (decreasing osmolarity). Osmotically induced alterations in the levels of mRNA coding for SDH could not be observed. These results suggest that the adaptation of sorbitol synthesis occurs by a rapid regulation of transcription or stability of specific mRNA. For a complete synthesis or degradation of AR 3-6 days are necessary. Thus sorbitol synthesis in IMCD is more rapidly adapted to increasing osmolarities than to decreasing osmolarities. PMID- 9949256 TI - Expression of IGF-I and IGF-II receptors in rat C6 glioma cells as a function of the growth phase. AB - In the present study, we examined the specific binding of IGF-I and IGF-II to their receptors in C6 glioma cells taken during different growth phases in culture: phase A, early stage of the exponential growth (48 h after seeding); phase B, late stage of the exponential phase (96 h after seeding); phase C, confluent phase (at 144 h after seeding); and phase D, stopped at 48 h post confluence. Scatchard analysis revealed higher Ka values for the IGF-IR during the exponential phases (A and B). The affinity of IGF-I for its receptor during the post-confluent phase (D) decreased to about half that at phase A (p < 0.01). Although lower at the later phase (D), the number of binding sites of the IGF-IR in the different tested growth stages in culture (A, B, and C) was not statistically different (p > 0.05). Conversely, the number of binding sites of the IGF-II/mannose-6-phosphate receptor appeared to increase during time in culture. The Ka values of the IGF-II/mannose-6-phosphate receptor decreased significantly during the culture time, phase D showing the largest decrease (50%) as compared with phase A (p < 0.005). These binding data suggest that IGF-I and IGF-II receptors are differentially expressed in rat C6 glioma cells in culture and are a function of the growth phase. PMID- 9949257 TI - Sodium, PMA and calcium play an important role on intracellular pH modulation in rat mast cells. AB - In a series of experiments aimed to understand the signaling pathways that regulate intracellular pH (pHi) in rat mast cells, the effect of different intracellular mechanisms on the activity of the Na+/H+ exchanger was studied. After promoting an artificial acidification with sodium propionate we determined the variations on pHi rate recovery. pHi was measured with the dye 2, 7 bis(carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester. We studied the effect that the inhibition of some cellular exchangers with different drugs induced on pHi. When the Na+/H+ exchanger was inhibited in the presence of amiloride, the recovery rate constant was twofold smaller than the control value. After the recovery, the final pH was lower than the initial value when the cells were treated either with amiloride or with 4, 4'-diisothiocyanatostilbene-2,2' disulfonic acid (an anionic antiport inhibitor). No effect was observed when the Na+/K+-ATPase or the Na+/Ca2+ exchanger were inhibited. The suppression of intracellular and extracellular calcium did not induced any change in pHi. The addition of thapsigargin, an activator of capacitative calcium influx, or the phorbol esther 12-O-tetradecanoylphorbol-13-acetate (PMA), a protein kinase C (PKC) activator, increased the activity of the antiporter. Both effects were abrogated by inhibition of the Na+/K+-ATPase with ouabain. The increase in cAMP levels did not affect the effect of PMA on pHi recovery, but it blocked the effect of thapsigargin. Our results indicate that rat mast cells regulate pHi by the combination of some anionic exchanger and the Na+/H+ antiporter. And also that the modulation of this exchanger is the consequence of the connection between different intracellular mechanisms, Na+/K+-ATPase-PKC-calcium, among which cAMP seems not to have a direct role. PMID- 9949258 TI - Effect of phenobarbital treatment on characteristics determining susceptibility to oxidants of homogenates, mitochondria and microsomes from rat liver. AB - This study was designed to investigate the possible oxidative changes associated with alterations in cytochrome P450 levels in rat liver. Accordingly, extent of peroxidative processes, cytochrome and antioxidant content, capacity to face an oxidative stress were determined in liver microsomes, mitochondria, and homogenates from normal and phenobarbital (PB)-treated rats. Liver content of microsomal and mitochondrial proteins was also determined by the values of the activities of marker enzymes (glucose-6-phosphatase and cytochrome oxidase, respectively) in liver homogenate and in two cellular fractions. The increase in the liver content of microsomal and mitochondrial proteins indicated that PB caused proliferation of both smooth endoplasmic reticulum and mitochondrial population. Treatment with PB also gave rise to a general increase in peroxidative reactions (evaluated measuring malondialdehyde and hydroperoxides (HPs)), in the different cell compartments, even though HPs were not found significantly increased in mitochondrial fraction. The increase in peroxidative processes was associated with significant decreases in antioxidant concentration (expressed in terms of equivalent concentration of an antioxidant, such as the desferrioxamine), in all preparations from PB-treated rats. The response to oxidative stress in vitro (evaluated determining the parameters characterizing light emission from preparations stressed with sodium perborate) showed a substantial PB-induced increase in the susceptibility to oxidative challenge only in liver homogenate. The lack of changes in the mitochondrial preparations is likely due to decrease in concentration of both free radical producing species and antioxidants. The lack of changes in microsomal fraction is apparently in contrast with its lower oxidant capacity and higher content of cytochromes which are able to determine sensitivity to pro-oxidants. However, it could be due to the ability of cytochrome P450 to interact with the active oxygen species formed at its active center. PMID- 9949259 TI - Possibilities and shortcomings of maintenance therapy in gastroesophageal reflux disease. AB - An overview is given of the current possibilities and shortcomings of medical therapy in reflux disease. With H2-receptor antagonists and prokinetics, roughly 60% of the patients can be maintained in remission; with proton pump inhibitors, remission can be maintained in approximately 90%. Whether there is a specific symptom pattern that benefits from cisapride is insufficiently evaluated. H2 receptor antagonists insufficiently reduce food-stimulated acid secretion and suffer from a degree of tachyphylaxis. Proton pump inhibitors suffer from acid rebound and occasionally cannot prevent nocturnal acid breakthrough. In general, medical intractability is virtually nonexistent with the current pharmaceutical possibilities and is therefore no longer per se an indication for surgery. PMID- 9949260 TI - Laparoscopic antireflux surgery--It's a wrap! AB - The surgical management of gastroesophageal reflux disease has been simplified by the availability of minimally invasive techniques to treat this condition. The indications and selection of patients remain the same as for open surgery and initial results with laparoscopic antireflux surgery show long-term results equal to, or better than open procedure. These procedures are technically demanding requiring surgeons skilled in advanced laparoscopy. The evaluation of patients, selection of patients for surgery, surgical techniques and anticipated outcomes are discussed. PMID- 9949261 TI - Left colon substitution with His' angle following total gastrectomy. Surgical technique using stapling devices. AB - To resolve the disadvantages of jejunal Roux-en-Y reconstruction following total gastrectomy, we attempted the use of left colon substitution with all anastomoses conducted using mechanical stapling devices. A His' angle was formed to reduce regurgitation esophagitis. About 25 cm of the left colon with the ascending branch of the left colic artery with an adequate blood supply was brought up to the remnant esophagus without tension on the mesentery. The colon graft was interposed between the esophagus and duodenum in an isoperistaltic fashion. Three anastomoses, esophagocolic, duodenocolic and colocolic, were completed with a circular stapling device. An end-to-side esophagocolonostomy was positioned about 3 cm distal from the blind end of the proximal colon stump. The proximal end of the left colon was pexied to the esophagus using 3-4 stitches to make a new His' angle. Gastrointestinal continuity was restored by a side-to-end colonoduodenostomy and an end-to-end colonocolonostomy. Fifteen gastric cancer patients underwent left colon substitution following total gastrectomy. The circular staple used for esophagocolonostomy and colonoduodenostomy was 25 mm in all patients, and for colonocolonostomy was 29 mm in 9 patients and 33 mm in 6 patients. No problems were encountered in any steps of the procedure, and faulty stapling was avoided. Neither anastomotic leakage nor necrosis of the interposed colon segment was seen, nor was late anastomotic stricture, in any patient. Barium radiograms of the interposed colon segment showed that the capacity and passage of the interposed colon were adequate, and regurgitation did not occur. Diet volume was satisfactory and weight loss minimal. PMID- 9949262 TI - Glucagon ameliorates pancreatic subcellular redistribution of lysosomal enzyme in rats with acute pancreatitis of closed duodenal loop. AB - The protective effects of glucagon on the exocrine pancreas were investigated in rats with a closed duodenal loop (CDL). A CDL in rats caused marked hyperamylasemia, pancreatic edema and pancreatic histological damage such as acinar cell vacuolization and interstitial edema. A CDL also caused redistribution of the lysosomal enzyme, cathepsin B, from the lysosomal fraction to the zymogen fraction as well as the activation of trypsinogen in pancreatic tissue. Moreover, a CDL caused a marked motality rate (40% at 48 h). However, treatment with glucagon at a dose of 1.0 mg/kg (subcutaneous injection) every 8 h (3 times) significantly inhibited these pancreatic injuries, improving the survival rate (95% at 48 h). These results indicate the important role of lysosomal enzymes in the pathogenesis of severe acute pancreatitis, and also suggest the possible usefulness of glucagon in the treatment of clinical pancreatitis. PMID- 9949263 TI - Duodenal leiomyosarcoma. AB - Malignant stromal tumours of the duodenum are rare. The efficacy of surgical resection for duodenal leiomyosarcoma was assessed in 5 patients treated over an 11-year period, probably the largest series treated by a single surgeon. There were 3 women and 2 men with an age range of 27-52 years. Tumours were large (8.5 21 cm diameter) and partly cystic (4 cases). They arose from the second (2), third (2) and fourth parts of the duodenum. Resection was a major undertaking and comprised either partial duodenectomy (n = 4) or Whipple resection. Two patients required a right hemicolectomy in addition. Two patients with positive resection margins had adjuvant radiotherapy. Operative time ranged from 4.0 to 6.25 h and blood loss from 1.8 to 4.5 litres. Two patients developed complications: a transient low-output biliary fistula and an infected haematoma requiring percutaneous drainage. The 2 patients with incomplete resection died of recurrent disease at 3 and 15 months. The 3 survivors are free of disease at 24, 60 and 66 months. The results support a policy of aggressive resection despite the technical difficulties posed by these large and vascular tumours. PMID- 9949264 TI - Management of common bile duct stones by laparoscopic cholecystectomy and endoscopic sphincterotomy: pre-, per- or postoperative sphincterotomy? AB - BACKGROUND/AIMS: The aim of this study was to evaluate the treatment of common bile duct stones (CBDS) by endoscopic sphincterotomy (ES) and laparoscopic cholecystectomy (LC), ES being performed either pre-, per- or postoperatively. METHODS: Between January 1990 and June 1997, 386 patients with a median age of 60 (range 18-92) years were treated for suspected or confirmed CBDS. The CBDS were uncomplicated in 264 cases (70%) but associated with a complication in 122 cases (30%), namely, cholangitis (69 cases) or acute pancreatitis (53 cases). ES combined with LC was carried out in 233 cases (60%): ES was preoperative (sequential treatment in two stages) in 197 cases (51%); peroperative in 30 cases (7%), or postoperative in 6 cases (2%). Laparoscopic extraction was performed in 58 cases (15%) and conventional surgery in 82 cases (21%). RESULTS: With respect to sequential treatment, endoscopic retrograde cholangiography showed the presence of CBDS in 117 cases (60%) and preoperative ES allowed the release of the CBDS in 82% of these cases. The complication rate of sequential treatment was 8% (15 cases) after ES and 7% (13 cases) after LC, with 1 death (0.5%). A peroperative ES performed after LC enabled evacuation of the CBDS in 28 cases (93%) without any complications or mortality. Postoperative ES was successful in 100% of cases with residual lithiasis in 16% (1 case) and a complication rate of 16% (1 case). CONCLUSION: Along with conventional surgery and laparoscopic extraction, ES combined with LC represents an effective alternative in the management of CBDS. Since it can be performed peroperatively, it allows a one stage, minimally invasive treatment of most uncomplicated CBDS. PMID- 9949265 TI - Role of chemoembolization in synchronous liver metastases from pancreatic endocrine tumours. AB - Endocrine tumours of the pancreas, even in case of liver involvement, are generally characterized by a slower evolution and a better prognosis, if compared with ductal carcinoma. This fact gives reason to a radical surgical approach, whenever possible, and to the research of any effective adjuvant treatment. For this purpose, hepatic transarterial chemoembolization (TACE) has been proposed in recent years for the treatment of metastatic endocrine tumours. Out of 80 patients suffering from endocrine tumours of the pancreas, observed between January 1985 and December 1996, 28 (35%) presented liver metastases at the time of diagnosis. Twelve of these patients were submitted to palliative resection of pancreatic tumour and one or more cycles of TACE. Overall survival was 50% (6/12); median survival was 35.4 months (range 4-75). These results suggest that chemoembolization, combined with surgical resection of primary malignancy, appears to be able to control the disease for a certain time and to increase the survival rate. PMID- 9949266 TI - Diagnostic accuracy in 2,351 patients undergoing appendicectomy for suspected acute appendicitis: A retrospective study 1986-1993. AB - AIMS: To investigate the pre-operative findings, accuracy, perforation rate and complication rate in 2,351 patients who underwent appendicectomy during 1986 1993. METHOD: The 2,351 records from patients who underwent surgery were analysed to determine whether the pre-operative investigations introduced can improve the diagnostic accuracy when analysed in total. RESULTS: The total diagnostic accuracy which was 70.9% in 1986 increased to a statistically significant figure of 87.1% in 1993. In female patients, the figure increased from 61.7 to 82.4% and in males from 82.0 to 91.2% during the studied period. The complication rate was in total 10.4% including a mortality of 0.21% (5 patients). CONCLUSION: We believe that with a combination of increased interest in patients with acute appendicitis, a wider use of active in-hospital observation, a more standardised pre-operative laboratory investigation and the use of ultrasonography, a high diagnostic accuracy could be reached without an increased rate of complications and perforations. PMID- 9949267 TI - Laparoscopic colorectal surgery: A five-year experience. AB - OBJECTIVE: The aim of this study was to assess the feasibility and outcome of 300 laparoscopic colorectal procedures performed within 5 years for both benign and malignant disorders. The specific purpose was to identify the impact of the learning curve on reducing morbidity and on improving the outcome of laparoscopic colorectal surgery. PATIENTS AND METHODS: All cases were divided into 3 groups: the first 100, the second 100 and the third 100 procedures were analyzed. Statistical analysis was performed by Student's t test and chi2 test. RESULTS: The laparoscopic procedure had to be converted to open surgery in 22 cases (mean conversion rate 7.3%). Thus, a total of 278 procedures could be performed laparoscopically. The mean major complication rate was 8.6%, minor complications occurred in 9.7%. The overall morbidity rate was 18.3%. In 44 cases, laparoscopic resections were performed for the cure of colorectal malignancy. The mean lymph node harvest was 12.8 nodes, no port-site recurrence was documented at a mean follow-up of 22 months. Analyzing our 5-year experience, the incidence of conversion showed a decline from 8.0% (1st and 2nd 100) to 6.0% in the last 100 procedures (p > 0.05). The major complication rate was significantly decreased from 15 to 6.0% (1st vs. 2nd 100) and was 5.0% in the 3rd group. The minor complication rate, overall morbidity rate and laparotomy rate have also been reduced (p > 0.05). The duration of surgery was shortened from 251.4 to 213.5 min (1st vs. 2nd 100, p < 0.05) and was 196.9 min in the last 100 procedures. Postoperative hospital stay was decreased from 16.3 to 14.3 days (1st 100 vs. 2nd 100, p > 0.05) and could be shortened to 11.2 days (2nd vs. 3rd 100, p < 0.05). CONCLUSION: With increasing experience, laparoscopic colorectal surgery can be performed with reduced morbidity and improved outcome. To evaluate the role of laparoscopic colorectal procedures, particularly for the cure of malignancy, prospective randomized trials are necessary. PMID- 9949268 TI - Long-term results after 75 anastomoses in the upper extraperitoneal rectum with the biofragmentable anastomosis ring. AB - BACKGROUND: Anastomoses in the rectum have a higher risk for complications compared with other gastrointestinal regions. Stapling devices and sophisticated developments in surgical suture materials did not lead to a substantial decrease of local complications. The bioabsorbable anastomosis ring (BAR) is a new alternative technique for creating gastrointestinal anastomoses. Accordingly, the aim of this prospective study was to evaluate the postoperative course and long term results of patients after anterior rectum resection using BAR. METHODS: From 1991 to 1996 75 BAR anastomoses were performed in the upper rectum at the Department of Surgery, University Hospital Wurzburg. Thirty-eight patients suffered from malignant, 37 from benign disease. Mean age was 61.4 years with no relevant differences in the gender. Mean follow-up was 31 months (4-63 months). The clinical course was evaluated, a questionnaire completed and/or a 3-monthly reevaluation with endoscopy conducted. Mortality, anastomostic bleeding, leakage and development of anastomotic stenosis were evaluated. RESULTS: Sixty-seven patients could be reexamined. There was no postoperative mortality and no anastomotic bleeding. Six patients (8%) developed an anastomotic leakage, of whom 3 (4%) required reoperation. None of the patients revealed a detectable stenosis in the anastomotic region during follow-up. CONCLUSION: The BAR procedure is a safe and suitable anastomotic technique after anterior rectum resection. PMID- 9949269 TI - Increased risk of wound complications and poor healing following laparotomy in HIV-seropositive and AIDS patients. AB - The number of individuals in the UK who are HIV seropositive is increasing as is their presentation with abdominal complications. Poor wound healing following anorectal surgery in HIV-positive patients has been well reported. This study reviews the incidence of wound complications following laparotomy. The hospital records of all HIV-positive patients who underwent laparotomy at a London teaching hospital over a 10-year period were reviewed and compared to an equal number of matched non-HIV patients. Between April 1986 and April 1996, 64 laparotomies were carried out on 53 patients. There was a significantly greater incidence of wound complications (chi2 = 12.75, 1 d.f., p = 0.0003) and wound breakdown (chi2 = 10.45, 1 d.f., p = 0.012) in the HIV group following laparotomy than in the non-HIV control group. PMID- 9949270 TI - Glucagonoma syndrome: survival 24 years following diagnosis. AB - The symptoms of necrolytic migratory erythema, diabetes, stomatitis, weight loss and diarrhoea represent the glucagonoma syndrome which has been recognized since the early 1970s. Because of its rarity (1 case/20-200 million population) late diagnosis is frequent which leads to a poor prognosis. The case described, originally reported in 1974, is the longest survivor to be documented in the literature, and is one of the original patients with a glucagonoma that helped to define the syndrome. PMID- 9949271 TI - Arterial ring encircling the bile duct with coexisting anomalous liver irrigation. AB - Analysis of the arterial system of the liver in a 64-year-old male cadaver revealed an anomaly of the branching of the proper hepatic artery. The right branch of the hepatic artery was missing, replaced by two segmental arteries, so that a 'trifurcation' occurred, consisting of two segmental arteries, anterior segmental and posterior segmental, and the left branch of the hepatic artery. These segmental arteries formed an arterial ring around the common hepatic duct, completely encircling it. A single cystic artery unusually originated from the posterior segmental artery. An extremely rare anatomical variation of the dorsal liver segment irrigation proves the fact that anatomical anomalies are usually multiple. The arterial blood supply for the dorsal liver segment is through four separate vessels ('quadruple type'), two originating from the left branch of the hepatic artery and two from the posterior segmental artery. These four arteries presented numerous anastomotic bridges among themselves. PMID- 9949272 TI - Effective intra-arterial chemotherapy for acinar cell carcinoma of the pancreas. AB - A 41-year-old man with a huge pancreatic tumor (acinar cell carcinoma) was treated by intra-arterial infusion chemotherapy with 5-fluorouracil (5-FU), mitomycin C (MMC) and cisplatin (CDDP). The tumor was significantly reduced, and he underwent a pancreaticoduodenectomy with complete excision of the tumor. Unfortunately multiple metastatic liver tumors were noted 5 months after resection. These tumors could also be markedly reduced by intra-arterial chemotherapy and the survival period was prolonged to 18 months. He suddenly died of sepsis but not from the pancreatic carcinoma. This case shows that intra arterial infusion chemotherapy with 5-FU, MMC and CDDP can be an effective regimen for the treatment of acinar cell carcinoma of the pancreas. PMID- 9949273 TI - Pseudomyxoma peritonei: Sudden cardiac death complicating post operative intraperitoneal treatment with 5-fluorouracil. AB - BACKGROUND: Pseudomyxoma peritonei, a tumor which spreads chiefly along peritoneal surfaces, has recently been treated by resection followed by intraperitoneal infusion of 5-fluorouracil (5-FU). Reports on the cardiotoxicity of this drug, given intravenously, indicate an incidence of 1.4-2.9%. Although several deaths have been reported following 5-FU therapy by continuous intravenous infusion, none has apparently been reported following bolus intravenous injection. METHOD: Radical resection of an extensive pseudomyxoma peritonei was performed. Following convalescence, intraperitoneal infusion of 5 FU was initiated in a daily dose of 20 mg/kg body weight (1,440 mg), planned for administration in multiple 5-day cycles. RESULTS: After three uneventful daily infusions of 5-FU, the patient suddenly died, apparently of a sudden cardiac event. Autopsy provided no explanation for his death. The coronary arteries were free of disease and no residual tumor was found. A review of the literature reveals no report of a cardiac death from 5-FU following its intraperitoneal administration. CONCLUSIONS: The fatality suggests the potential toxicity of 5- FU when administered intraperitoneally, a factor to be considered in decisions to use this drug intraperitoneally. PMID- 9949274 TI - The influence of the maternal heart rate on the uterine artery pulsatility index in the pregnant ewe. AB - We investigated the influence of the maternal heart rate on the uterine artery pulsatility index in pregnant ewes. We used an external pacemaker to alter the heart rate of 5 pregnant ewes at 16-17 weeks of pregnancy and examined the effect of changes in the maternal heart rate on the uterine artery flow velocity waveforms and the pulsatility index, as determined by Doppler velocimetry. The uterine artery pulsatility index showed a significant negative correlation with the maternal heart rate. There were no significant changes in other hemodynamic parameters. The maternal heart rate had a significant influence on the uterine artery pulsatility index. PMID- 9949275 TI - The complexity of pregnancy anemia in Dar-es-Salaam. AB - OBJECTIVES: To investigate the main causes of anemia in pregnancy in Dar-es Salaam and identify appropriate investigations at all levels of care. MATERIALS: All pregnant women booking for antenatal care at 2 clinics (n = 2,235) were screened for anemia. Investigations for etiology of anemia were done in all anemic women (Hb <10.5 g/dl) (n = 361). METHODS: Blood cell counts, microscopy of blood films, S-ferritin, C-reactive protein, HIV, stool parasite and bone marrow analysis were performed. RESULTS: Iron deficiency dominated in 86% and malaria in 1/3 of anemia cases. Since 42% had indication of ongoing inflammation, S-ferritin was less useful as indicator of iron deficiency but blood film microscopy identified most cases. PMID- 9949276 TI - Factors influencing vaginal fetal fibronectin concentrations during pregnancy. AB - In order to evaluate factors influencing fetal fibronectin concentrations during pregnancy a total of 312 vaginal samples for fetal fibronectin measurements and microbiological culture were collected and later included in a stepwise regression analysis. Preterm premature rupture of membranes, a modified Bishop score >/=6 (p < 0.0001), a low vaginal polymorphonuclear leukocyte count (p < 0. 002), the presence of Enterococcus faecalis (p < 0.0001), Prevotella species (p < 0.05), a bacterial vaginosis-associated flora (p < 0. 05), and a non-lactobacilli dominated vaginal flora (p < 0.05) were associated with an elevated vaginal fetal fibronectin concentration. PMID- 9949277 TI - Total fibronectin in maternal plasma as a predictor for preeclampsia. AB - OBJECTIVE: To assess the ability of measuring total maternal plasma fibronectin in predicting the risk of developing preeclampsia. METHOD: In a cohort of 657 initially normotensive pregnant nulliparous women blood samples were collected at 26, 30 and 34 weeks of gestation. After delivery 3 groups were selected for measurement of total plasma fibronectin. The first group comprised 24 women who developed preeclampsia; the second 21 women who developed gestational hypertension, and the third 89 age-matched controls who remained normotensive. RESULTS: In women who developed preeclampsia the fibronectin levels were higher at 26 (p < 0.01), 30 (p < 0.001) and 34 weeks of gestation (p < 0.001) than in pregnant controls. In the general population of pregnant nulliparous women the estimated risk of subsequent preeclampsia correlated with the fibronectin level at each measurement. In women with fibronectin levels within the 25th percentile at the 26th week of gestation, the risk was /=6.2%. The change in fibronectin levels between 26 and 34 weeks of gestation was the only variable that remained statistically associated with preeclampsia (p = 0.0002) in multivariate analysis. In this model the risk figures for the corresponding percentiles were /=5.8%, respectively. CONCLUSION: Longitudinal assessment of the change in total fibronectin levels predicted preeclampsia slightly better than cross-sectional analysis of fibronectin at any gestational age. Nevertheless, measurement of total fibronectin in maternal plasma could not be proven to be a useful clinical predictor for preeclampsia in a general obstetric population of nulliparous women. PMID- 9949278 TI - Endothelial cell lesion in preeclampsia. Morphofunctional study using umbilical endothelial cells. AB - Morphofunctional study of umbilical cords from pregnancies complicated by preeclampsia shows both activation and lesion of endothelium. The cellular findings in umbilical cords from pregnancies complicated by preeclampsia can be summarized as: (i) higher number of cells with secretion bladders and increase in the number and size of both secretion bladders and microvilli-like protrusions; (ii) increase in collagen, fibrin, fibronectin and lipidic vesicles in the vessel wall; (iii) vacuolization of endothelial cells; (iv) presence of lipidic vacuoles and lipophages in the vessel wall; (v) erosion and disorganisation of the endothelium that exposes extracellular proteins to the blood flow. Endothelial cell cultures from preeclamptic pregnancies show kinetic disorders and cell detachment. The results confirm that an endothelial cell lesion occurs in preeclampsia and this cellular disorder can be reproduced in vitro. PMID- 9949279 TI - Characterization of 5-hydroxytryptamine receptors mediating circular smooth muscle contraction in the human umbilical artery. AB - The study was performed to characterize pharmacologically the contractile 5 hydroxytryptamine (5-HT) receptors in the circular smooth muscle of the isolated human umbilical artery. Effects of agonists and antagonists for different 5-HT receptor subtypes were studied in intact endothelium vessel segments. All agonists induced concentration-dependent circular smooth muscle contractions. The potency was in declining order 5-HT > alpha-methyl-5-HT > sumatriptan >/= 2 methyl-5-HT. The effects of 5-HT and alpha-methyl-5-HT were antagonized by ketanserin, as well as methiothepin. The contractile effect of sumatriptan was antagonized by methiothepin but not by ketanserin. The 5-HT3 receptor antagonist, MDL 72222, did not affect the contraction by any of the agonists, including 2 methyl-5-HT. It is concluded that the 5-HT-induced contraction in the circular smooth muscle of the human umbilical artery seems to be mediated by a mixed population of 5-HT1-like receptors and 5-HT2 receptors. PMID- 9949280 TI - Clinical application of intrauterine sonography with high-frequency, real-time miniature transducer in gynecologic disorders. Preliminary report. AB - Our purpose was to determine whether intrauterine sonography with high-frequency, real-time miniature transducer (20 MHz) is useful for the diagnosis of gynecologic disorders. The study consisted of 37 women: 8 normal volunteers, 2 with molar pregnancy, 4 fibromyoma, 4 endometrial polyp, 1 intrauterine adhesion, 1 septate uterus, 5 atypical hyperplasia, 8 endometrial cancer, and 4 with cervical cancer. Comparison of diagnostic efficacy for gynecologic disorders between transvaginal and intrauterine sonography was made. The probe was easily introduced into the endometrial cavity in all patients. No notable complications were encountered. In subjects with a normal uterus, higher resolution for endometrial texture was obtained with intrauterine sonography than with transvaginal scanning. In patients with molar pregnancy, typical vesicular echoes were clearly identified. In patients with fibromyoma, myoma nodules were not clearly visualized because of poor attenuation of ultrasound. In subjects with endometrial polyp, intrauterine adhesion, and septate uterus, intrauterine lesions were clearly identified. In patients with atypical hyperplasia, high echogenicity of the endometrium was characterized. Myometrial invasion of the endometrial cancer was estimated correctly in 6 of 8 patients (75%). Intrauterine sonography could clearly detect early cervical invasion of the cervical cancer in all 4 patients, but transvaginal sonography could not do it. Intrauterine sonography with a high-frequency, real-time miniature transducer might be a useful diagnostic modality in gynecologic disorders, especially in the evaluation of early cervical cancer, endometrial cancer, and possibly in infertility practice. PMID- 9949282 TI - Regional localization of immunoreactive c-fos and prolactin in human endometrium during the normal menstrual cycle. AB - The objective of the present study was to evaluate the cyclic changes and regional localization of immunoreactive c-fos and prolactin (PRL) in the human endometrium, using immunohistochemistry. Immunoreactive PRL was found in the epithelium of 9.1% of the proliferative specimens and in 55.6% of the secretory specimens (p < 0.05, Fisher's exact test). In the endometrial stroma, immunoreactive PRL was present in 9.1 and 66.7% of the proliferative and secretory samples, respectively (p < 0.01). Immunoreactive c-fos predominated in the stroma and was identified in 54.5% of the specimens in the proliferative phase, but in only 7.1% of those in the secretory phase (p < 0.05). The progesterone/estradiol ratio was lower in the patients expressing immunoreactive c-fos (median = 13.1 ng/ml) compared to those who did not (median = 84.5 ng/ml, p < 0.05). We conclude that immunoreactive c-fos is found mostly in stromal cells during the proliferative phase of the menstrual cycle, and is sharply reduced during the secretory phase, when the endometrium is under progesterone stimulation - attested by PRL production. PMID- 9949281 TI - Glutathione S-transferase in human endometrium: quantitation and interindividual variability in isoform content. AB - OBJECTIVES: The goals of the present study were to determine whether human endometrium contains glutathione S-transferases (GSTs), to identify the isoforms present (if any) and to assess the causes of any intersubject variability which was observed. METHOD: Hysterectomy patients (n = 32, 13 with endometrial carcinoma) were examined in the core study. The ability of cytosol from these endometria to conjugate 1-chloro-2,4-dinitrobenzene was measured. Additional studies with chemical inhibitors and monoclonal antibodies to GSTpi were also performed. RESULTS: The pattern of inhibition caused by ethacrynic acid and cibacron blue strongly suggests substantial interindividual variability in type (alpha and pi dominant) and amount ( approximately 10-fold) of this important group of enzymes. Significantly lower GST activity was seen in cancer patients who were smokers when compared with all other subjects (p < 0.05). CONCLUSION: There are substantial interindividual differences in the GST content of human endometrium. Furthermore, lower GST activity in tissues from endometrial carcinoma patients with a history of smoking may have contributed to the neoplastic transformation of this tissue. PMID- 9949283 TI - The role of oxytocin in relation to female sexual arousal. AB - Oxytocin is clearly involved in human reproduction and serves an important role in sexual arousal. Oxytocin serum levels were measured before and after sexual stimulation in 12 healthy women. Values of oxytocin 1 min after orgasm were significantly higher (p < 0.05) than baseline levels. This finding supports the hypothesis that oxytocin plays a major part in human sexual response both in neuroendocrine function and postcoital behavior. PMID- 9949284 TI - Recurrence and survival analyses of 1,115 cervical cancer patients treated with radical hysterectomy. AB - Many clinicopathological factors of cervical cancer are still controversial in their prognostic significance. The case records of 1,115 patients who received radical hysterectomy at the Veterans General Hospital, Taipei, from 1980 to 1989 were collected to evaluate prognosis-related factors by univariate and multivariate analyses. The pathology was reviewed retrospectively by one pathologist. Ten parameters known to be prognostic in the literature were included for analysis. Univariate analysis showed that patients with all these factors had higher recurrence rates. However, when the effects of parametrial invasion, progressive stage and stromal invasion were weighed against the presence of lymph node metastasis, their influence on recurrence became unimportant. Nevertheless, these factors still influenced prognosis when there was no lymph node metastasis. Multivariate analysis of both recurrence and survival time in the patients with squamous cell carcinoma shared a consensus that pelvic lymph node metastasis and deep stromal invasion were significant risk factors. We conclude that these simplified and consistent results obtained by multivariate analysis provide a basis for subclassification of patients to predict prognosis and change therapy. PMID- 9949286 TI - Intermittent cisplatin therapy for stage-III ovarian cancer patients following clinical remission. AB - Intermittent cisplatin (CDDP) administration as consolidation therapy for stage III ovarian cancer was studied. No patients with residual disease at surgery or at second-look operation or patients with <8 U/ml of CA125 after remission induction chemotherapy were enrolled in this study. Fifteen subjects received intermittent chemotherapy, and 10 control patients did not. CDDP of 20 mg/m2 for 5 days was administered every 3-4 months for 5 years. A significant increase in 5 year survival rate was found in the intermittent chemotherapy group when compared with the control group. Side effects from the intermittent chemotherapy were controllable. Intermittent CDDP therapy seems to be an effective consolidation therapy for stage-III ovarian cancer patients. PMID- 9949285 TI - Granulosa cell tumor of the ovary. Immunohistochemical evidence of low proliferative activity and virtual absence of mutation of the p53 tumor suppressor gene. AB - BACKGROUND AND METHODS: Because the use of immunohistochemistry in the diagnosis of granulosa cell tumor (GCT) has not been fully explored, routinely processed (formalin-fixed, paraffin-embedded) tissue from 11 GCT, adult type, was investigated immunohistochemically (ABC method) with a broad spectrum of antibodies against various markers, including p53 and Ki-67. All of the tumors exhibited typical morphology, were limited to the ovary (stage I), and 7 cases followed a benign clinical course. RESULTS: All the tumors exhibited strong expression of vimentin, but most other antigens (including smooth muscle actin) were expressed infrequently by a minority of tumor cells or not at all. Tumor cells in 9 GCT expressed inhibin A. All the tumors exhibited very low proliferative activity, fewer than 10% of the tumor cell nuclei being stained by the antibody MIB-1 (Ki-67 antigen). The antibody D07 revealed marked overexpression of p53 protein in only one tumor. Clinical outcome was not found to be related to immunophenotypic differences. CONCLUSIONS: The diagnosis of GCT should be based primarily on the typical morphology revealed by conventional stains, but additional immunohistochemical staining with a small panel of selected antibodies (for example, against keratin, vimentin, and inhibin A) may be helpful in a few cases. The very low proliferative activity and the lack of overexpression of p53 protein are consistent with the benign clinical behavior of the majority of GCT. PMID- 9949287 TI - Endoscopic management of a case of complete septate uterus with unilateral pyometra. AB - We report a case with an unusual mullerian anomaly: complete uterine septum and pyometra in the right hemicavity and pyocolpos along with a longitudinal vaginal septum. A patient with recurrent low-grade fever and lower abdominal pain was admitted. Pyometra and pyocolpos were detected in the right uterine hemicavity and in the right hemivagina. The septa were resected, the cavities were irrigated, and the patient was treated with antibiotics. The patient conceived 8 months later. Patients with abnormal vaginal findings should be approached with caution; precise knowledge of urogenital anatomy and urogenital anomalies is necessary in the management of these patients. PMID- 9949288 TI - Sequential steps in hematogenous metastasis of cancer cells studied by in vivo videomicroscopy. AB - Understanding metastatic spread of cancer is of upmost importance to developing successful strategies to treat this disease. In this review, we present a picture of the process of hematogenous metastasis from the initial arrest of cancer cells, their extravasation, postextravasation migration, and their replication to form tumors, based on experimental results using in vivo videomicroscopy. The cancer cells are initially arrested by size constraints within minutes of entering the circulation and with little hemodynamic destruction. Within 24-48 h >80% of these cancer cells extravasate as single cells by adhesion to and spreading along the vessel wall, often using pseudopodial projections to move into the surrounding tissue without disrupting the microcirculation. Some of the extravasated cells also use pseudopodial projections to migrate to specific structures in the tissue where they can replicate. Many cancer cells can persist as dormant cells, neither dividing nor undergoing apoptosis. Only a small fraction of extravasated cells begin to divide to form micrometastases, and only a very small fraction of these micrometastases continue to grow to form tumors. Possible clinical implications are that (1) initial arrest and extravasation may be difficult to prevent and thus may be poor therapeutic targets; (2) dormant single cells will not be affected by conventional cancer therapies which are designed to treat actively growing cells; and (3) regulation of growth of cells after extravasation is key to determining whether clinically evident metastases form - this stage of metastasis thus offers promising targets for new antimetastasis drugs. PMID- 9949289 TI - Hyaluronidases in tissue invasion. AB - Hyaluronidases are broadly distributed enzymes with varying substrate specificities, a wide range of pH optima, and different catalytic mechanisms. They may be used by organisms to invade one another. Hyaluronidases have also been invoked as mechanisms for tumor invasion and metastatic spread. In this review, we will concentrate more on the different kinds of hyaluronidases involved in tissue invasion other than cancer metastasis, present some of the rapidly accumulating new data, and address the paradox that both hyaluronidase as well as its hyaluronan substrate are associated with invasion. PMID- 9949290 TI - Use of tetracycline as an inhibitor of matrix metalloproteinase activity secreted by human bone-metastasizing cancer cells. AB - Bone metastases are a common complication in prostate and breast cancer patients. It leads to extensive morbidity and eventually mortality. Matrix metalloproteinases are implicated in various steps of development of metastasis, through their ability to degrade the extracellular matrix. Increased matrix metalloproteinase activity of tumor cells has been associated with a higher metastatic potential. Inhibitors of metalloproteinases have been shown to effectively reduce or prevent the formation of metastases. The family of tetracyclines is able to inhibit matrix metalloproteinase activity through chelation of the zinc ion at the active site of the enzyme. Using tumor cell lines relevant to bone metastases, i.e. PC-3, MDA-MB-231, Hs696, B16/F1, we showed that tetracycline and derivatives of tetracycline, namely doxycycline and minocycline, also induced cytotoxicity. The effective concentrations are relatively high for plasma, but are clinically achievable in the bone, since tetracyclines are osteotropic. All four bone-metastasizing tumor cells produced and secreted various matrix metalloproteinases. Doxycycline was able to inhibit the activity of 72- and 92-kDa type IV collagenase secreted by bone-metastasizing cells by 79-87%. These characteristics could make tetracycline a unique candidate as a therapeutic agent to prevent bone metastases in cancer patients with a high likelihood for development of bone metastasis. Studies using animal models of experimental bone metastasis will be necessary to confirm this. PMID- 9949293 TI - Complications of subcutaneous infusion port in the general oncology population. AB - Subcutaneous infusion ports (SIPs) represent a valid method for long-term chemotherapy. The SIPs have several advantages over other methods of venous access: they are easy to implant under local anaesthesia, have less discomfort for the patients, allow low costs, can be implanted in day hospital, and can be managed ambulatorily. However, SIPs have delayed complications, frequently related to clinical conditions of the neoplastic patients, and immediate complications, often due to the placement technique. From March 1992 to March 1997 we placed, under local anaesthesia and under fluoroscopic control, 102 SIPs in 99 general oncology patients for long-term chemotherapy (88% solid, 12% haematological tumours). The percutaneous venous access devices were in the subclavian vein in 96% of the cases and in the internal jugular vein in 4% of them. Immediate complications were: 1 haemopneumothorax, which required thoracic aspirations and two blood transfusions, 1 loop of the tunneled part of the catheter without alterations in SIP function, and 1 left jugular thrombosis in a patient with subclavian veins already thrombosed. The venous access was in the subclavian vein in the first 2 cases, and it was not necessary to suspend the therapeutic program. In the third instance, implanted in jugular vein, it was necessary to remove the SIP. Delayed complications were: 1 necrosis of the skin over the port, 1 infection of subcutaneous pocket, 2 infections of the system, 1 catheter deconnection, and 3 catheter ruptures with embolization of the catheter tip. The SIPs were removed in all cases but 1 in whom infection was successfully treated by appropriate antibiotic therapy. Embolization of the catheter required removal from the pulmonary artery under fluoroscopic guidance in the cardiac catheterization laboratory. In conclusion, infection and thrombosis are the two major complications of SIP in general oncology patients. In these cases it is not necessary to remove systematically the system, but a correct therapy (antibiotic, fibrinolytic agents) can be utilized with good results. The catheter rupture is often due to the wear over the costoclavicular angle. The interventional radiology is the method of choice in the treatment of the catheter embolization by rupture or dislocation. The experience of the surgical and nursing staff is probably the most important factor in decreasing the total rate of complications. PMID- 9949291 TI - Modulation of tumor cell motility by plasmin. AB - Using a pure chemotactic model, we investigated the effect of plasmin on tumor cell motility. In the presence of various extracellular matrix proteins, plasmin facilitated motility of human melanoma LOX and lung cancer Lu-99 cells. Laminin contributed most to the action of plasmin. The cell motility induced by plasmin and laminin was chemokinetic in nature and was almost completely suppressed by alpha2-antiplasmin. To further characterize the action of plasmin, various signal transduction kinase inhibitors were tried out. The results suggested that plasmin may modulate cell motility through protein kinase C and mitogen-activated protein kinase cascades in cooperation with laminin. PMID- 9949292 TI - Detection and clinical correlations of ras gene mutations in human ovarian tumors. AB - In epithelial ovarian neoplasms K-ras codon 12 gene mutations show a wide variation fluctuating between 4-39% in invasive carcinomas and 20-48% in borderline malignant tumors. In this study, we showed the pattern of point mutations in codon 12 of the K-ras, H-ras and N-ras genes, using polymerase chain reaction restriction fragment length polymorphism analysis in 74 tissue specimens of Greek patients with epithelial ovarian tumors. K-ras and H-ras gene mutations were detected in 11/48 (23%) and 3/48 (6%) cases with primary invasive ovarian carcinomas, respectively, while N-ras gene mutations were not found. No mutation of K-, H- and N-ras genes was detected in 23 ovarian cystadenomas. In 1 out of 3 borderline ovarian tumors (33%) we found an H-ras gene mutation. The prevalence of mutations in K-ras gene was 1/8 (13%) in mucinous, 7/29 (24%) in serous, 1/3 (33%) in endometrioid and 2/8 (25%) in clear-cell adenocarcinomas and in H-ras gene 1/8 (13%) in mucinous and 2/29 (7%) in serous adenocarcinomas. Analysis of the results revealed no significant correlation between ras gene mutations and clinicopathological parameters or clinical outcome of this primary invasive ovarian carcinoma population. Our present data suggest that ras gene mutations in invasive ovarian carcinomas occur in 29% of Greek patients and are not associated with the differentiation of the epithelial cells or the response of patients to adjuvant platinum-based chemotherapy. PMID- 9949294 TI - Intensified adjuvant cyclophosphamide, methotrexate and 5-fluorouracil therapy: a dose-finding study for ambulatory patients with breast cancer. AB - Escalating doses of cyclophosphamide were given every 3 weeks as adjuvant treatment for women operated for breast cancer to determine the maximum tolerated dose of cyclophosphamide that can be given with constant doses of methotrexate (40 mg/m2) and 5-FU (600 mg/m2; CMF) as an outpatient treatment without the routine use of granulocyte colony-stimulating growth factor (G-CSF). The dose of cyclophosphamide was increased by 250 mg/m2 starting from the dose of 1,000 mg/m2. Mesna was given to prevent cystitis. The criteria for dose-limiting toxicity were grade IV granulocytopenia lasting for longer than 48 h, granulocytopenic infection or other grade IV toxicities. G-CSF and ofloxacin were used if grade IV granulocytopenia continued for longer than 48 h or if granulocytopenic infection occurred. At the dose level of 1,500 mg/m2 (500 mg/m2/week) 22 (92%) of the 24 patients had grade IV granulocytopenia during the 6 CMF cycles given, but only 3 (13%) had granulocytopenic fever. G-CSF was used in 28% of the cycles at this dose level. Other toxicities included complete alopecia (79%), nausea and vomiting. Sixteen (80%) of the premenopausal women became postmenopausal. At the dose level of 1,750 mg/m2 all 3 patients treated had to be hospitalized after the first cycle due to neutropenic infection (n = 2) or intractable vomiting even though prophylactic G-CSF was used. We conclude that intravenous CMF with a cyclophosphamide dose of 1,500 mg/m2 given at 3-week intervals with the selective use of prophylactic G-CSF is feasible as adjuvant treatment for patients with breast cancer. PMID- 9949295 TI - Elevation of the pacing threshold: a side effect in a patient with pacemaker undergoing therapy with doxorubicin and vincristine. AB - A 56-year-old female patient with an IgG plasmocytoma first diagnosed 5 years before underwent 3 cycles of chemotherapy according to the VAD scheme. A VVI pacemaker had been implanted 3 years earlier. After each cycle, the output of the pacemaker had to be increased as the pacing threshold had increased, resulting in a slow pulse. This case demonstrates that patients with a pacemaker that undergo chemotherapy with cardiotoxic agents must be followed carefully. PMID- 9949296 TI - Hemolytic-uremic syndrome during therapy with estramustine phosphate for advanced prostatic cancer. AB - 3 weeks after commencing treatment with estramustine phosphate, typical manifestations of hemolytic-uremic syndrome occurred in a 66-year-old patient with prostate cancer. Urinary tract obstructions were excluded and no renal damage could be identified. An improvement in renal function was achieved by stopping estramustine phosphate and infusing adequate amounts of fluids and electrolytes. Anemia and thrombocytopenia also progressively improved after the discontinuation of chemotherapy. Nausea and vomiting, hepatotoxicity, impotence, reduced libido and hypercalcemia are major side effects of estramustine phosphate, and would be difficult to explain our observations without considering the role played by estramustine phosphate. Our observations suggest that estramustine phosphate might play either a direct role or produce a side effect within the context of latent paraneoplastic syndrome. The improvement in renal function which occurred when treatment stopped might confirm our hypothesis. PMID- 9949297 TI - Rivizor--a new third-generation aromatase inhibitor for the treatment of advanced breast cancer after tamoxifen failure. AB - Rivizor (vorozole) is a new, highly potent and selective third-generation aromatase inhibitor for treatment of advanced breast cancer. In an open-label study, 30 postmenopausal women failing tamoxifen therapy received Rivizor 2.5 mg once daily until disease progression. Rivizor produced clinical benefit (partial response or no change) in 16 of 27 evaluable patients (59.3%). Five patients (18.5%) had a partial response (UICC criteria) which lasted for a median of 15 months (range 14-42.5 months), 11 patients had disease stabilization for a median of 14 months (7-24 months), and 11 patients had disease progression. Median time to first response was 3.9 months (3-27.5 months): estimated median survival time for all patients was 22.8 months (2-52.8 months) and estimated median time to disease progression was 10.8 months (1.4-42.4 months). Estradiol levels decreased to below limits of detection from 1st month of treatment until study end. Androstenedione, 17alpha-hydroxyprogesterone, dehydroepiandrosterone, and free testosterone levels were unaffected by Rivizor. ACTH stimulation tests demonstrated that Rivizor does not interfere with adrenal mineralocorticoid and glucocorticoid steroid synthesis. Adverse events were mild-to-moderate. Rivizor might be an effective and well-tolerated alternative treatment for postmenopausal advanced breast cancer patients following tamoxifen failure. PMID- 9949298 TI - nm23 in the primary and metastatic sites of gastric carcinoma. Relation to AFP producing carcinoma. AB - Tumor metastasis is the major cause of treatment failure and death in cancer patients. The present study was designed to extrapolate the association of nm23 expression with acquisition of metastatic potential of gastric carcinoma with special reference to the alpha-fetoprotein-producing gastric carcinoma (APGC). The primary tumor with surrounding normal mucosa and metastatic lymph nodes of 30 patients with APGC and 29 randomly selected matched controls of non-AFP gastric carcinoma (NAGC) were immunostained for nm23 and an image analyzer system was used for quantitative evaluation. Overexpression of nm23 was noted in 71% (42/59) of the primary tumors and 18% (10/55) of the metastatic tumors and there was no difference between the APGC and NAGC groups. The overexpression of nm23 in the primary tumors correlated with tumor invasion, metastasis and progression in all cases and similar results were obtained in the APGC and NAGC groups except for the tumor stage which was insignificant in the APGC group. The patient survival was adversely affected by the overexpression of nm23 in the primary sites and downregulation in the metastatic sites in all cases but lost their significance in the multivariate analysis. However, nm23 status did not affect patient survival in the APGC group. PMID- 9949299 TI - Infrequent presence of anti-c-Myc antibodies and absence of c-Myc oncoprotein in sera from lung cancer patients. AB - To clarify the host immune response and explore a new serological marker of lung cancer, we examined serum c-Myc antigens and auto-antibodies against c-Myc in 68 lung cancer patients and 30 healthy volunteers using bacterially synthesized glutathione S-transferase c-Myc fusion proteins and immunoblotting. The detection rate of anti-c-Myc antibodies was 13.2% (9/68) in lung cancer patients and 3.3% (1/30) in healthy volunteers. These anti-c-Myc antibodies were directed toward exon 2 alone (4/68), exon 3 alone (1/68), and both exon 2 and exon 3 (4/68) of c Myc. Circulating c-Myc antigen was not detected in any individuals with lung cancer and normal controls. Age, sex, performance status, histology, stage, smoking history, and prior treatment of the patients with and without anti-c-Myc antibodies were not significantly different. The low incidence of anti-c-Myc antibodies and c-Myc antigens in peripheral blood suggests that these examinations are not useful in the serological diagnosis of lung cancer. PMID- 9949300 TI - Expression of DCC protein in colorectal tumors and its relationship to tumor progression and metastasis. AB - A loss of heterozygosity (LOH) at the DCC gene locus was detected in colorectal tumors, and this LOH might be related to metastasis. The aim of this study was to determine DCC protein expression in colorectal cancer and to evaluate its prognostic value. Allelic loss of the DCC locus was observed in 16 of the 23 patients (66.7%). In all 16 patients with LOH, DCC expression was decreased in the cancer tissue compared with the adjacent normal mucosa. All 23 colorectal tumors had decreased expression of this protein relative to the adjacent normal colonic mucosa in Western blot analysis. The levels of DCC protein were significantly lower in cancer tissues than in adenoma tissues. Decreased DCC protein expression was also observed by immunohistochemistry in the colorectal cancer cases. There were significant correlations between DCC protein expression and histologic type, venous invasion, and hematogenous metastasis. Patients with DCC-protein-negative tumors had a greater relative risk of recurrence compared with those whose tumors were DCC protein-positive. The 5-year survival rate was 91.0% in patients with DCC-protein-positive tumors, and 58.8% in those with DCC protein-negative tumors; these differences between the two groups of patients were significant (p < 0.01). In multivariate analysis using the Cox regression model, DCC protein expression emerged as an independent prognostic indicator. These findings suggested that a decrease in DCC expression may have an important role in the progression of colorectal cancers and may be a biologic marker of prognostic significance. PMID- 9949301 TI - N-acetyl-beta-hexosaminidase activity and isoenzymes in human gastric adenocarcinoma. AB - The enhancement of lysosomal beta-hexosaminidase degradative activity in different human cancer tissues is fairly well documented. Gastric tumors have attracted considerable attention on the basis of their social incidence and clinical recurrence. Here we report a comparative study of beta-hexosaminidase activity and of its isoenzymes beta-hexosaminidase A (HA) and beta-hexosaminidase B (HB) from gastric adenocarcinoma and normal mucosa. Tumor beta-hexosaminidase activity from crude extracts and chromatographically resolved HA and HB forms were analyzed as regards their physicochemical and enzymatic properties and were compared to similar samples obtained from control tissue. The existence of one active site in the beta-hexosaminidase enzyme responsible for both N-acetyl-beta D-glucosaminidase and N-acetyl-beta-D- galactosaminidase activities was determined. Apart from their relative contributions to beta-hexosaminidase activities, two major differences appeared in tumor HA and HB forms with respect to the corresponding controls: (1) the presence of an atypical heat-stable HB isoenzyme in gastric adenocarcinoma, and (2) a significantly increased Vmax of the HA form acting on both p-nitrophenyl-N-acetyl-beta-D-glucosaminide and p nitrophenyl-N-acetyl-beta-D-galactosaminide substrates. The results show that the beta-hexosaminidase HA and HB isoenzymes from gastric adenocarcinoma display different patterns of response from the same forms from other human tumors. PMID- 9949302 TI - Human small cell lung cancer cells produce brain natriuretic peptide. AB - The tumoral production of brain natriuretic peptide (BNP) was studied using 9 small cell lung cancer (SCLC) cell lines which were established from patients with small cell lung cancer. BNP cDNA fragment was generated from 20 microg total RNA which was prepared from the human right cardiac atrium by reverse transcription-based polymerase chain reaction. Expression of BNP mRNA was detected in 30 microg total cellular RNA from these cell lines by RNase protection assays in 5 of 9 SCLC cell lines. Radioimmunoassays using 125I radiolabeled human BNP(1-32) and antihuman BNP(1-32) antibody detected immunoreactivity in cell pellets from SCLC cell lines which had detectable BNP mRNA. BNP immunoreactivity in the cell pellets corresponds with the data from BNP mRNA analyses. We conclude that SCLC cells have detectable BNP mRNA by RNase protection assay and BNP immunoreactivity in the cells. PMID- 9949304 TI - Detection of loss of heterozygosityat microsatellite loci in esophageal squamous cell carcinoma. AB - Microsatellite alterations at 3 genetic loci (chromosomes 2p, 3p and 17p) were analyzed in 25 tumors (20 primary tumors and 5 metastatic lymph nodes) from 20 patients after surgical treatment for esophageal cancer. DNA samples from tumors were compared with control DNA from lymphocytes obtained from the peripheral blood of the individual patients. Microsatellite alterations [microsatellite instability (MSI) and loss of heterozygosity (LOH)] were detected in 15% of 20 primary tumors with marker D2S123 (chromosome 2p), 55% with marker D3S1067 (chromosome 3p) and 50% with marker TP53 (chromosome 17p). The 3-year disease free survival rate of the 10 patients who had tumors without alterations or with an alteration at only 1 of 3 microsatellite loci was 75% and it was better than that of the 10 patients who had tumors with alterations at 2 or 3 microsatellite loci (48%, p = 0.049). This finding suggests that esophageal cancer with alterations at multiple microsatellite loci might have strong malignant potential. However, MSI was only detected in one of 20 patients, which suggests that MSI might not play an important role in the development of this cancer. Three of 5 metastatic lymph nodes showed no LOH even though primary tumors of these patients exhibited LOH with 1 or 2 markers, and 1 metastatic lymph node had LOH that was detected with D3S1067 even though the primary tumor of this patient had no LOH with all markers. Thus, clonal heterogeneity might exist in esophageal squamous-cell carcinomas. PMID- 9949303 TI - Ovarian cancer: loss of heterozygosity frequently occurs in the ATM gene, but structural alterations do not occur in this gene. AB - Ataxia-telangiectasia is a multisystem recessive disease characterized clinically by cerebellar ataxia, oculocutaneous telangiectasias, immunodeficiency, sensitivity to radiomimetic agents and an increased predisposition to cancer. This pleiotropic disorder is caused by mutations in the ATM gene, which is located at the human chromosomal region 11q23. Loss of heterozygosity (LOH) at 11q22-q23 is a frequent event in ovarian cancer, suggesting the presence of a tumor suppressor gene in this region. We have found that LOH in the ATM gene occurred in 44% of informative cases in a series of 22 primary ovarian tumors. LOH of this region occurred at the same frequency during the advanced stages (III IV; 3/9, 33%) as in the early stages (I-II; 4/13, 31%) of ovarian cancer. To investigate the role of ATM in ovarian cancer, we used a PCR-based single-strand conformation polymorphism assay for mutation detection of the entire coding sequence of the ATM gene (65 exons) in 22 ovarian tumors. No somatic alterations of the ATM gene were found in these ovarian cancer samples including those with LOH present in the ATM gene. Our study has identified a region (11q23) which probably contains a frequently altered tumor suppressor gene in ovarian cancer, and this gene does not appear to involve the coding sequences of the ATM gene. PMID- 9949305 TI - Serial transplants of DMBA-induced mammary tumors in Fischer rats as a model system for human breast cancer. VI. The role of different forms of tumor associated stress for the regulation of pineal melatonin secretion. AB - Previous studies on human breast cancer patients showed a decline in circulating melatonin levels corresponding to primary tumor growth and an increase when relapse occurred. The aim of the current investigation was to study in an experimental model possible mechanisms involved. Inbred female F344 Fischer rats were used for serial passages derived from a chemically induced mammary adenocarcinoma. Animals with slow-growing carcinosarcomas at passage 2 showed a significant elevation of nocturnal urinary melatonin (23. 00-07.00 h; +50%, p < 0.05) and a nominal increase in plasma melatonin (+41%; 02.00-03.00 h). By contrast, these parameters were significantly depressed in animals with fast growing sarcomas (urinary melatonin: -22%, p < 0.025; plasma melatonin: -56%, p < 0. 01). At passage 2 nocturnal pineal N-acetylserotonin (02.00-03.00 h) was significantly enhanced (+62%, p < 0.05) probably due to an increased activity of serotonin-N-acetyltransferase (SNAT, +45%), the rate-limiting step of pineal melatonin biosynthesis converting serotonin to N-acetylserotonin. The activation of SNAT may be due to a stimulation of the sympathetic nervous system (urinary noradrenaline; NA: +243%, p < 0.005) when the cellular immune system responded towards tumor growth (urinary biopterin, +214%, p < 0.005). At passage 12 SNAT and N-acetylserotonin were unaffected but a depletion of plasma tryptophan (-34%, p < 0.0001), the precursor amino acid of melatonin, was found. The marginal decline in pineal serotonin (-18%, p < 0.05) disputes that the drastic depletion in circulating melatonin (-56%, p < 0.01) can be exclusively explained by a reduced availability of tryptophan. Therefore, the involvement of an additional mechanism has to be postulated, such as a degradation of melatonin via indoleamine 2,3-dioxygenase, an extrahepatic enzyme which has been detected in tumor tissue and is related to tryptophan 2,3-dioxygenase (TDO). TDO occurs only in the liver, is highly specific for L-tryptophan and is induced by glucocorticoids which would account for the observed depletion of plasma tryptophan resulting from a tumor-associated activation of the hypothalamo pituitary-adrenal axis (urinary corticosterone +208%, p < 0.01). These findings present first explanations for the previously observed modulation of melatonin levels in cancer patients but also illustrate the high degree of complexity of mechanisms involved in the interactions between tumor growth and the immunoneuroendocrine system. PMID- 9949306 TI - Methods and effectiveness of environmental control. AB - In recent years the role of allergen exposure and atopy, and the interaction between them in the clinical expression of allergic disease, has been examined in a quantitative manner in epidemiologic studies. Such analyses suggest that avoidance of exposure to domestic allergens is a critical element in integrated strategies for both the prevention and the management of asthma. The promise of primary intervention in high-risk infants, as shown in the Isle of White study, has been confirmed in a recent study in Japan, and at least 4 similar trials are in progress. Applying these principles to the management of symptoms in patients with chronic asthma has proved more difficult, and it is likely that many earlier studies were poorly designed to test the hypothesis that allergen avoidance was clinically useful. Recent studies with patients moved to high altitudes during seasonal reductions in mite exposure and randomized controlled interventions in houses have all shown improvements in clinical manifestations of asthma. These recent trials have also demonstrated something that was less certain-that massive reductions in domestic allergen exposure can be achieved and that people will adopt the significant changes to their domestic environment and lifestyles if the risks and benefits are known. In the future, it seems likely that better study designs, as well as improvements in methods to monitor exposure and clinical outcomes, will provide further support for the role of allergen avoidance in the prevention and management of asthma. PMID- 9949307 TI - Molecular mechanisms of CD8+ T cell-mediated delayed hypersensitivity: implications for allergies, asthma, and autoimmunity. AB - Delayed-type hypersensitivity (DTH) is defined as the recruitment of T cells into tissues to be activated by antigen-presenting cells to produce cytokines that mediate local inflammation. CD8+ T cells are now known to mediate DTH responses in allergic contact dermatitis, drug eruptions, asthma, and autoimmune diseases. This inflammatory effector capability of CD8+ cytotoxic T cells was previously poorly recognized, but there is now considerable evidence that these diseases may be mediated by CD8+ DTH. The difference between CD8+ T cells and CD4+ T cells mediating DTH relates to the molecular mechanisms by which antigens are processed and presented to the T cells. Antigens external to the cell are phagocytosed and processed for presentation on MHC class II molecules (eg, HLA-DR) to CD4+ T cells. In contrast, internal cytoplasmic antigens are processed by the endogenous pathway for presentation on MHC class I molecules (eg, HLA-A, -B, and -C) to CD8+ T cells. External allergens can also enter the endogenous pathway to be presented to CD8+ T cells. These include many contact sensitizers, chemical and protein respiratory allergens, viral antigens, metabolic products of drugs, and autoantigens. The resulting CD8+ T-cell response explains the role of CD8+ T-cell DTH mechanisms in allergic contact dermatitis, asthma, drug eruptions, and autoimmune diseases. PMID- 9949308 TI - The gelatin story. PMID- 9949309 TI - A murine model of IgE-mediated cow's milk hypersensitivity. AB - BACKGROUND: Cow's milk allergy (CMA) is one of the leading causes of food allergy in children. Understanding the mechanisms involved in the development of CMA has been hampered by the lack of suitable animal models. OBJECTIVE: We sought to develop a mouse model of IgE-mediated cow's milk hypersensitivity (CMH) that mimics the clinical features of immediate CMA in humans. METHODS: Three-week-old C3H/HeJ mice were sensitized by intragastric administration of cow's milk (CM) plus cholera toxin and boosted 5 times at weekly intervals. RESULTS: CM-specific IgE antibody levels were significantly increased at 3 weeks and peaked at 6 weeks after the initial feeding. Intragastric challenge with CM at week 6 elicited systemic anaphylaxis accompanied by vascular leakage, significantly increased plasma histamine, and increased intestinal permeability to casein. Histologic examination of intestinal tissue revealed marked vascular congestion, edema, and sloughing of enterocytes. The role of IgE in mediating CMH was confirmed by abrogation of passive cutaneous anaphylaxis reactions by heat inactivation of immune sera. Development of IgE-mediated CMH in this model is likely to be TH2 cell mediated because in vitro stimulation of spleen cells from mice allergic to CM induced significant increases in the levels of IL-4 and IL-5, but not IFN gamma. CONCLUSION: This model should provide a useful tool for evaluating the immunopathogenic mechanisms involved in CMA and for exploring new therapeutic approaches. PMID- 9949310 TI - Gene expression of the GATA-3 transcription factor is increased in atopic asthma. AB - BACKGROUND: High expression of IL-5 by T cells in the airways of asthmatic individuals is believed to play a fundamental role in the eosinophilia associated with this disease. Recently, the transcription factor GATA-3 was shown to be critical for IL-5 gene expression in TH2 cells in vitro. OBJECTIVE: Our aim was to examine the expression of GATA-3 mRNA and its colocalization within the airways of asthmatic and nonasthmatic individuals. METHODS: We investigated the association between GATA-3 gene expression, airway inflammatory cells, and IL-5 gene expression in bronchoalveolar lavage fluid and bronchial biopsy specimens from atopic asthmatic subjects (n = 10) and normal control subjects (n = 10). RESULTS: We report that GATA-3 mRNA expression is significantly increased in the airways of asthmatic subjects compared with those of normal control subjects (P <.001). Numbers of cells expressing GATA-3 transcripts correlated significantly with reduced airway caliber (P <.05) and airways hyperresponsiveness (P <.05) in asthmatic subjects. Colocalization studies showed that the majority (approximately 60% to 90%) of GATA-3 mRNA+ cells in asthmatic airways were CD3(+) T cells, with smaller contributions from major basic protein+ eosinophils and tryptase+ mast cells. The density of GATA-3 mRNA+ cells correlated significantly with the numbers of cells expressing IL-5 mRNA (P <.001, r = 0.879 for bronchoalveolar lavage fluid; P <. 05, r = 0.721 for biopsy specimens). Furthermore, double in situ hybridization demonstrated that approximately 76% of GATA-3 mRNA+ cells coexpressed IL-5 mRNA and that 91% of IL-5 mRNA+ cells coexpressed GATA-3 mRNA. CONCLUSION: The results of this study provide the first evidence of increased GATA-3 gene expression in association with IL-5 mRNA+ cells in asthmatic airways. These findings support a causal association between augmented GATA-3 expression and dysregulated IL-5 expression in atopic asthma. PMID- 9949311 TI - The clinical pharmacology of brompheniramine in children. AB - BACKGROUND: Brompheniramine has been widely used in the treatment of allergic rhinitis and other disorders during the past 4 decades. There are no published studies of its clinical pharmacology in children. OBJECTIVES: This study was performed to test the hypothesis that brompheniramine would have a prompt onset of action and a 24-hour duration of action in children. METHODS: Before brompheniramine 4 mg was ingested, and at intervals from 0.5 to 30 hours thereafter, blood samples were obtained for quantitation of plasma brompheniramine concentrations by means of HPLC. Concurrently, epicutaneous tests with histamine phosphate were performed; wheals and flares were traced at 10 minutes, and the areas were measured by using a computerized digitizing system. RESULTS: In 14 children, mean age 9.5 +/- 0.4 years (SEM), the peak brompheniramine concentration was 7.7 +/- 0.7 ng/mL, and the time at which peak concentrations occurred was 3.2 +/- 0.3 hours. The terminal elimination half-life was 12.4 +/- 1.1 hours, and the oral clearance was 20.2 +/- 2.1 mL/min/kg. Compared with predose areas, the wheals and flares produced by histamine phosphate 1 mg/mL were significantly decreased from 0.5 to 30 hours and from 1 to 30 hours, respectively (P <.05), with mean maximum inhibition at 12 (52% +/- 9%) and 6 hours (72% +/- 10%), respectively. CONCLUSIONS: In children a single dose of brompheniramine produces prompt, long-lasting peripheral H1 -blockade. Revised dosage regimens may be needed in this population. PMID- 9949312 TI - Evaluation of materials used for bedding encasement: effect of pore size in blocking cat and dust mite allergen. AB - BACKGROUND: Mattress and pillow encasings are recommended for patients allergic to dust mites. Many encasements block allergen and are vapor permeable but do not allow free passage of air through the material. Recently, breathable fabrics made from tightly woven synthetic fibers or nonwoven synthetics have been recommend as encasements. OBJECTIVE: The purpose of this study was to develop a method for testing encasement materials made of breathable fabrics. METHODS: Dust samples containing a known quantity of allergen (Der f 1, Der p 1, and Fel d 1) were pulled across a variety of fabrics using a modified dust trap. Airflow through the dust trap was controlled with a vacuum pump. Five minutes after dust was introduced, the pump was shut off. A filter located downstream of the fabric collected allergen passing through the fabric during the test and was assayed with ELISA for the relevant allergen. Fabrics to be tested were obtained from manufacturers and specialty catalogs. RESULTS: As the average pore size decreases, the airflow through a fabric becomes restricted, and the pressure differential created by the vacuum pump increases. Dust mite allergens (Der f 1 and Der p 1) were blocked below detectable limits by fabrics of less than 10 microm in pore size. Fabrics with an average pore size of 6 microm or less blocked cat allergen (Fel d 1). CONCLUSION: The method we developed provided a rigorous and reliable test for leakage of common indoor allergens through breathable barrier fabrics. Our results show that tightly woven fabrics and nonwoven synthetic fabrics can block common indoor allergens but still allow airflow. PMID- 9949313 TI - Sputum analysis, bronchial hyperresponsiveness, and airway function in asthma: results of a factor analysis. AB - BACKGROUND: Recent studies have shown weak associations among FEV1, bronchial hyperresponsiveness (BHR), sputum eosinophils, and sputum eosinophil cationic protein (ECP), suggesting that they are nonoverlapping quantities. The statistical method of factor analysis enables reduction of many parameters that characterize the disease to a few independent factors, with each factor grouping associated parameters. OBJECTIVE: The purpose of this study was to demonstrate, by using factor analysis, that reversible airway obstruction, BHR, and eosinophilic inflammation of the bronchial tree, as assessed by cytologic and biochemical analysis of sputum, may be considered separate dimensions that characterize chronic bronchial asthma. METHODS: Ninety-nine clinically stable patients with a previous diagnosis of asthma underwent spirometry, sputum induction, and histamine inhalation tests. RESULTS: Most patients were nonobstructed (FEV1, 91% +/- 20%); a low level of bronchial reversibility (FEV1 increase after beta2 -agonist, 7.8% +/- 9.2%) and BHR (histamine PC20 FEV1 geometric mean, 0.98 mg/mL) were found. Sputum eosinophil differential count (12.4% +/- 17.7%) and sputum ECP (1305 +/- 3072 microg/mL) were in the normal range of our laboratory in 38 and 22 patients, respectively. Factor analysis selected 3 different factors, explaining 74.8% of variability. Measurements of airway function and age loaded on factor I, PC20 FEV1 and beta2 -response loaded on factor II, and sputum ECP and eosinophils loaded on factor III. Additional post hoc factor analyses provided similar results when the sample was divided into 2 subgroups by randomization, presence of airway obstruction, degree of BHR, percentage of sputum eosinophils, or concentration of sputum ECP. CONCLUSIONS: We conclude that airway function, baseline BHR, and airway inflammation may be considered separate dimensions in the description of chronic asthma. Such evidence supports the utility of routine measurement of all these dimensions. PMID- 9949314 TI - IL-4 and IL-5 mRNA expression in induced sputum of asthmatic subjects: comparison with bronchial wash. AB - BACKGROUND: The local production of TH2 -type cytokines is thought to orchestrate the ongoing eosinophilic inflammation and contribute to the pathophysiologic features of allergic asthma. Previous studies investigating cytokine expression in asthmatic individuals have used invasive fiberoptic bronchoscopy techniques. To date, there have been no reports of cytokine mRNA expression in induced sputum as a means of quantifying local inflammatory events. OBJECTIVES: We examined whether IL-4, IL-5, and IFN-gamma mRNA expression could be detected in cells from induced sputum in subjects with mild asthma and normal control subjects. In addition, we compared the profile of inflammatory cells and cytokine mRNA in sputum and bronchial wash fluid. METHODS: Cells positive for IL-4, IL-5, and IFN gamma mRNA were determined by using in situ hybridization on cytospun aliquots of sputum induced by successive inhalations of hypertonic saline. Inflammatory cells were quantified by using immunologic cell surface markers and immunocytochemistry. RESULTS: IL-4 and IL-5 mRNA were detected in the sputum of all asthmatic subjects, and the number of cells expressing these cytokines was significantly higher than that found in control subjects. Colocalization studies showed CD3-positive T cells were the major sources of IL-4 and IL-5 mRNA. CONCLUSIONS: This study demonstrates that induced sputum can be used to detect mRNA for TH2 -type cytokines in bronchial asthma and that the increase in IL-4 and IL-5 mRNA expression is similar to that seen with more invasive techniques. The qualitative differences in inflammatory cell numbers between sputum induction and bronchial wash are consistent with their sampling of different airway compartments. PMID- 9949315 TI - An evaluation of zafirlukast in the treatment of asthma with exploratory subset analyses. AB - BACKGROUND: Consensus asthma guidelines recommend antileukotriene agents as alternative therapy to existing anti-inflammatory medications; however, the full therapeutic potential of these medications has not yet been determined. OBJECTIVE: The purpose of this study was to assess the efficacy and safety of the oral leukotriene receptor antagonist zafirlukast (20 mg twice daily) in subgroups of patients who have asthma with the use of integrated data from four 13-week trials. METHODS: The trials had comparable designs, entry criteria, and clinical assessments. Patient subgroups were characterized by demographic and baseline asthma characteristics. Analysis of covariance models were tested for overall treatment effect and for interactions between treatment and subgroup characteristics. RESULTS: Patients with mild-to-moderate asthma (12 to 76 years old) who were treated with albuterol alone were randomized (nZ = 879; nP = 605) and included in subset analyses. Significant overall treatment effects, favoring zafirlukast, were noted for measures of daytime and nighttime symptoms, beta2 agonist use, and pulmonary function (P <.05). A significant, quantitative, treatment-by-age interaction was noted for beta2 -agonist use (P <. 03), suggesting greater reductions in rescue medication use with increasing patient age. Compared with placebo, similar size and/or direction of response was noted with zafirlukast in the various subgroups, indicating a benefit with zafirlukast regardless of subgroup. Significant treatment-by-strata interactions (P <.05), favoring zafirlukast, were noted for various outcome measures in subgroups with the greatest amount of baseline beta2 -agonist use (>8 puffs/day) and with greater baseline peak flow variability (>/=20%) and baseline airflow obstruction (FEV1 /forced vital capacity ratio, <0.70). The overall treatment failure rate was significantly lower in the zafirlukast group compared with the placebo group (P <.003). No associations were observed between any adverse events and subgroups defined by demographic characteristics. CONCLUSIONS: Exploratory subset analyses showed that zafirlukast is similarly efficacious in patients with asthma who have differing demographic characteristics and degrees of subjective symptoms. Additionally, zafirlukast appears to be incrementally beneficial in patients with more moderate disease, defined by a greater requirement for as-needed rescue medication and more abnormal pulmonary function at baseline. Over 13 weeks, zafirlukast was well tolerated and demonstrated a safety profile clinically indistinguishable from placebo. PMID- 9949316 TI - T-cell receptor contact and MHC binding residues of a major rye grass pollen allergen T-cell epitope. AB - BACKGROUND: T cells are pivotal in the elicitation of allergic diseases. Analogues of T-cell epitope peptides with a modification at a T-cell receptor (TCR) contact site can alter selected T-cell effector functions. Thus the ability to modulate allergen-specific T-cell responses towards TH1 -like by stimulation with peptide analogues may downregulate allergic inflammation. OBJECTIVES: The purpose of this study was to characterize the minimal epitope recognized by cloned T cells of a dominant Lol p 5 epitope, p105-116, and identify the critical residues involved in TCR and MHC contact. METHODS: Using peptides with progressive truncation of N- and C-terminal residues in T-cell proliferation assays, we identified the core epitope recognized by cloned CD4(+) T cells. An additional series of peptides with single amino acid substitutions were used in T cell proliferation and live-cell MHC binding assays. Taken together, these results allowed identification of MHC binding and TCR contact residues of p105 116. RESULTS: The core epitope of p105-116 was identified as residues 107-114. Within this core epitope, 3 residues were found to be important for MHC binding, positions 107, 110, and 112, whereas those at positions 108, 109, 110, 111, and 113 were putative TCR contact residues. CONCLUSIONS: The identification of the TCR and MHC contact residues of a dominant Lol p 5 T-cell epitope and analogues of this peptide capable of modulating T-cell responses will allow the evaluation of these peptides' potential as immunotherapeutic agents for rye grass pollen allergic disease. PMID- 9949317 TI - Rhinoconjunctivitis and asthma caused by vine pollen: a case report. AB - BACKGROUND: The vine (Vitis vinifera) is a cultivated plant that is found in some European and American countries. Its pollen gathers in small quantities during a short pollination period in the months of May and June. Allergy to vine pollen has not been previously documented. OBJECTIVE: We sought to describe a case report of allergy to vine pollen documented on the basis of anamnesis, cutaneous, provocation, and specific IgE determination tests. METHODS: An allergenic extract was obtained from collected V vinifera pollens by aqueous standard procedures. Pollen counts and pollination periods of this and other common pollens in the area where the patient became symptomatic were studied. Cutaneous tests and the presence of specific IgE to the pollen extracts were performed by prick, CAP, and RAST techniques. Bronchial and conjunctival tests with the involved pollen extracts were also carried out to identify the sensitizing allergens. Five healthy subjects and 5 pollinic patients were used as control subjects and underwent the same tests. RESULTS: Skin prick test responses with vine pollen at different concentrations were positive for the studied patient and negative for the control subjects. Patient serum revealed a total IgE titer of 334 IU/mL and a specific IgE value of 1.3 PRU/mL (RAST class 2) to vine pollen. Bronchial and conjunctival provocation test responses were also positive when the patient was challenged with V vinifera extract. CONCLUSION: Exposure to the pollen of the vineyard plants (V vinifera) can induce immunologic sensitization and rhinoconjunctivitis/asthma. PMID- 9949318 TI - Fluticasone propionate powder: oral corticosteroid-sparing effect and improved lung function and quality of life in patients with severe chronic asthma. AB - BACKGROUND: Many patients with severe asthma are dependent on oral corticosteroids for maintenance control of their disease. Treatments that allow patients to be weaned off oral corticosteroids may help to minimize the risk of side effects associated with their chronic use. OBJECTIVE: This study evaluated whether inhaled fluticasone propionate powder could maintain pulmonary function while reducing the dose of oral prednisone in patients with chronic, severe asthma. METHODS: Oral prednisone-dependent (5 to 40 mg/day) adolescents and adults with asthma (n = 111; mean FEV1 = 61% of predicted value) were randomized to placebo or twice daily fluticasone propionate 500 or 1000 microg administered by means of a multidose powder inhaler for 16 weeks in a double-blind, parallel group study. Patients underwent controlled prednisone reduction on the basis of predetermined asthma stability criteria. RESULTS: Oral prednisone was eliminated by 75% and 89% of patients in the twice daily 500 and 1000 microg fluticasone propionate groups, respectively, versus 9% of the placebo group (P <.001). FEV1, morning and evening peak expiratory flow, asthma symptoms, albuterol use, and nighttime awakenings improved with fluticasone propionate treatment, achieving statistical significance (P or = 0.01) with vestibulo-ocular tests in 5 of 6 comparisons among BVH patients. Posturography SOT results, however, correlated poorly with other vestibulospinal measures: correlations were statistically significant for only 7 of 18 comparisons with clinical balance and gait function (r < or = 0.69, P > or = 0.01) and with 2 of 12 comparisons for gait laboratory dynamic stability measures (r < or = 0.55, P > or = 0.01) among the BVH patients. When both the platform and visual surround moved (SOT 6), however, correlations were statistically significant with static standing clinical measures (r = 0.51 to 0.69, P < 0.01) and with whole-body maximum moment arm during paced gait (r = 0.55, P < 0.01). Posturography scores for the UVH patients did not significantly correlate with any vestibulo-ocular or other vestibulospinal measures. These data indicate that among patients with BVH posturography SOT scores relate at best modestly with accepted measure of vestibulo-ocular function, less well with clinical measures of balance control, and poorly with dynamic gait-performance measures. We conclude that posturography SOT does not assess vestibulospinal function. PMID- 9949348 TI - Morphometric analysis of horizontal canal nerves of chronically diabetic rats. AB - Horizontal canal nerves of 3-, 6-, 9-, and 12-month-diabetic rats were compared with those of age-matched controls. The myelin sheaths of the horizontal canal nerves in diabetic rats were thinner than those of age-matched controls (mean +/- SD 0.63 +/- 0.04 micron (n = 16) vs. 0.71 +/- 0.05 micron (n = 9); p < 0.0001, one-tailed t test). Regression analysis revealed that myelin sheath thickness did not correlate with severity of diabetes, but myelin thinning did occur as a function of the duration of diabetes (p < 0.05, regression ANOVA). The progression of myelin thinning over time is consistent with the possibility of an accelerated decline in vestibular function with age in diabetic patients. That myelin thinning did not correlate with the severity of diabetes suggests that this thinning is not directly related to the aging effects attributed to nonenzymatic glycosylation of myelin proteins. Multivariate analysis revealed a significant difference between diabetic and control groups when fiber diameter and intrasheath diameter were considered together (p < 0.008, canonical discriminant-function analysis). Diabetic and control groups did not differ significantly in total nerve fiber counts. In the diabetic group, however, nerve fiber counts were higher in animals with higher blood glucose levels (p < 0.02, linear-regression ANOVA; r2 = 0.49). The finding of higher nerve fiber counts in more severely diabetic rats is consistent with an earlier transmission electron microscopic finding of false myelinated nerve fiber profiles in micrographs from more severely diabetic rats. These false profiles are believed to represent phagocytosis-like Schwann cell reactions against their own myelin, triggered by excess myelin glycosylation. PMID- 9949349 TI - Tracheal transplantation: defining the vascular territory of the canine cranial thyroid artery. AB - The management of long-segment tracheal stenosis remains an unsolved clinical problem that has significant implications for the survival of some patients and the quality of life of others. However, recent advances in microvascular tissue transfer may allow tracheal transplantation to be used as a treatment option. Studies in dogs have demonstrated that the reanastomosis of the cranial thyroid artery (CTA) after the transplantation of a short segment of trachea sustains cartilage viability. However, the distal perfusion zone of the CTA within the canine trachea has not been described. Hence it is unclear what length of trachea can be safely harvested, with use of the CTA as the donor artery, without risking ischemia of the distal trachea. This study determined the perfusion territory of the CTA by use of latex or dye infusion via the thyroid branches of the CTA. Findings in five perfusion-fixed cadaver mongrel dogs (8 to 12 kg) were studied. In each dog, both common carotid arteries were dissected and the CTAs identified. The right CTA was ligated and the left common carotid artery was ligated cranial to the CTA. The left common carotid artery was perfused for 10 minutes under 100 mm Hg pressure with black india ink/saline solution (20:1000 ml) or with blue latex solution. Perfusion territories were determined by grossly and microscopically measuring the region of stain in the endolaryngeal and endotracheal airways. The results demonstrated that up to 18 ipsilateral rings of the canine trachea are perfused after injection of dye under physiologic pressure into the CTA. Contralateral staining was also noted, but to a lesser degree. These results suggest that the canine CTA may perfuse, on average, a 16- to 17 ring tracheal segment. PMID- 9949350 TI - Mohs '98: single-procedure Mohs surgery with immediate reconstruction. AB - For more than 50 years, the Mohs technique has offered both the highest cure rate for skin cancers and the maximum preservation of surrounding normal tissue. Mohs skin cancer excision is traditionally performed by a Mohs dermatologist, followed by a secondary repair by a head and neck or plastic surgeon. This study comprises a review of 300 cases involving single-procedure Mohs therapy with immediate one anesthetic reconstruction. The data reviewed include types of reconstructions, cosmetic results, complications, and recurrence rates. In addition to offering the psychologic and quality advantages of immediate closure, the procedure allows patients to return to work sooner. With changes in technique ranging from the chemosurgery of the 1930s to the fresh-tissue methods of the 1970s, single procedure Mohs is the logical next step in the evolution of Mohs surgery. PMID- 9949351 TI - Microscopic detection of occult malignancy in the adult tonsil. AB - Microscopic evaluation of all adult tonsillar specimens has been considered essential despite the low incidence of unsuspected pathologic conditions. We evaluate whether routine histologic examination of clinically benign adult tonsillar specimens is indicated. We retrospectively reviewed pathology results from all tonsillectomies performed on patients ages 18 years or older at our institution from 1989 through 1996. Three groups were created on the basis of indications for tonsillectomy: (1) routine tonsillectomies for benign disease, (2) asymmetric tonsils, and (3) search for unknown primary lesions. Demographic data and pathologic findings in each group were analyzed. In 1280 tonsillectomies performed for benign disease there were no malignancies (0%) and 32 cases (2.50%) with clinically unsuspected benign pathologic conditions. In 31 cases of tonsillar asymmetry, two cases with malignant lymphoma (6.5%) and three cases with benign pathology (9.7%) were identified. In nine patients with squamous cell carcinoma metastatic to the neck, two occult primary lesions were identified in the ipsilateral tonsil. Our results suggest that histologic evaluation of adult tonsils removed for benign disease may be clinically unnecessary. The elimination of microscopic examination of tonsils removed from patients whose clinical presentation is entirely consistent with benign disease poses minimal risk of missing clinically significant pathologic conditions. Substantial costs for negative examinations may be avoided. PMID- 9949352 TI - Percutaneous endoscopic gastrostomy: avoiding complications. AB - This study evaluates our complications arising directly or indirectly from placement or management of percutaneous endoscopic gastrostomy (PEG) tubes and provides recommendations for avoidance of complications. Seventy-one patients received PEG tube placement by otolaryngologists between January 1991 and May 1997. Records were reviewed for diagnoses, combined procedures, and complications. Addressing potential causes of complications prompted modification of our technique of PEG tube placement and management. Twenty-three patients received PEG for dysphagia/aspiration unrelated to neoplasia, 11 received PEG with staging endoscopy, 11 received PEG after treatment for head and neck neoplasm, and 26 received PEG at the time of primary resection. Major complications included retained PEG hub and delayed colon abscess ultimately resulting in death. Minor complications included skin abscesses, cellulitis, and early and late vasovagal response with PEG tube removal. An airway emergency, on attempted oral airway intubation, resulted in an aborted PEG attempt and constituted another complication outside the 4 groups stated above. The major complication was not found within a literature review. We have modified our management for avoidance of this complication. We believe the causes of the minor complications have been identified, and with additional modifications in our technique, we have not had any similar complications recently. The recommended techniques are discussed in detail. PMID- 9949353 TI - Cyclin D1 expression as a prognostic parameter in papillary carcinoma of the thyroid. AB - Papillary carcinoma of the thyroid is the most common thyroid cancer. At the time of clinical presentation, most papillary carcinomas are still confined to the thyroid gland, and appropriate surgical treatment achieves a 95% 5-year survival rate. Certain carcinomas, however, behave in a much more aggressive fashion. Because specific therapies do not exist, for those tumors that have escaped local control, patients with disseminated disease have little or no chance of permanent cure or long-term survival. Cyclin D1, a protein that plays a critical role in the control of the cell cycle, has been shown to be overexpressed in a variety of human neoplasias and may serve as a prognostic parameter of disease progression. To explore the role played by cyclin D1 in the pathogenesis of thyroid papillary carcinoma, we have quantitated, by computerized image analysis, the immunohistochemical expression of cyclin D1 in formalin-fixed, paraffin-embedded tissue from 35 conventional papillary carcinomas of the thyroid and correlated the results with established clinicopathologic parameters and available survival data. PMID- 9949355 TI - Learning curve in endoscopic sinus surgery. AB - The existence of a long learning curve for endoscopic sinus surgery has been proposed as a reason for rigorous and extensive training to prepare physicians to perform this surgery. In this article, the author--who participated in this type of training program--examines his experience over a 5-year period to assess the effect of rigorous training on the learning curve for endoscopic sinus surgery. Beginning with the first day of practice after training, 5 years with 393 cases were evaluated for complications and the need for revision surgery. The results were analyzed in 100-case groups. The results show no difference in major and serious complications or revision surgery rates. However, a statistically significant difference in the minor-complication rate, specifically frontal-sinus stenosis, was found from the first half to the second half of the experience. These findings show that, with rigorous training of the physician, the learning curve can largely be completed during residency training, allowing the new practitioner to perform endoscopic sinus surgery safely and with good results. PMID- 9949354 TI - Role of gastroesophageal reflux in pediatric upper airway disorders. AB - Gastroesophageal reflux (GER) into the laryngopharynx causes or contributes significantly to a variety of upper respiratory problems in children. The pH probe, laryngeal examinations, and broncholveolar lavage results for children with subglottic stenosis, recurrent croup, apnea, chronic cough, laryngomalacia, recurrent choanal stenosis, vocal fold nodules, and chronic sinusitis/otitis/bronchitis were reviewed in an effort to quantify the role of GER in each of these disorders. This review suggests that GER plays a causative role in subglottic stenosis, recurrent croup, apnea, and chronic cough. It is an important inflammatory cofactor in laryngomalacia and possibly in true vocal cord nodules and problematic recurrent choanal stenosis. GER is also an important inflammatory cofactor in chronic sinusitis/otitis/bronchitis but may be the result of chronic illness in the older patients. PMID- 9949356 TI - Alternative to endoscopic sinus surgery in the management of pediatric chronic rhinosinusitis refractory to oral antimicrobial therapy. AB - We determined the safety, feasibility, and efficacy of a treatment regimen consisting of maxillary sinus aspiration and irrigation with or without adenoidectomy, followed by culture-directed intravenous antibiotics and oral prophylaxis, for children with chronic rhinosinusitis refractory to oral antimicrobial therapy. Twenty-seven children (age 1-12 years, mean 6.7 years) with symptomatic (mean duration 16 months) and computed tomography-proven sinus disease, which persisted despite at least 1 month of oral antibiotics, were treated. Twenty-four patients (89%) had complete resolution of their presenting symptoms after intravenous therapy; in 3 (11%), intravenous therapy failed and endoscopic sinus surgery was required. Follow-up data were available for 26 of the children (96%); 23 of them had initial complete resolution. At last follow-up (mean 282 days, range 26-1095 days), 10 of these 23 patients (44%) remained asymptomatic, and 13 (57%) had had at least one other episode of sinusitis (mean 1.0, range 1-3) treated with oral antibiotics, with resolution. Treatment-related complications included superficial thrombophlebitis (7%), diarrhea (7%), intravenous catheter guide-wire kink requiring venotomy (4%), and serum sickness like syndrome (4%). These preliminary results suggest that this treatment plan is relatively safe and feasible and that it may be a reasonable alternative to endoscopic sinus surgery in children with chronic rhinosinusitis unresponsive to orally administered antimicrobial therapy. PMID- 9949357 TI - Ozone effects on the immediate-phase response to allergen in the nasal airways of allergic asthmatic subjects. AB - Epidemiologic and clinical trials have suggested that exposure to ozone increases airway hyperresponsiveness and inflammatory response to inhaled nasal allergen challenge in allergic asthmatic subjects. Previous studies have demonstrated an increased late-phase response to nasal allergen challenge; however, the early phase response is unknown. We sought to characterize the early-phase response by measuring mast-cell inflammatory mediators and cellular influx at time points immediately following ozone exposure and subsequent allergen challenge. A cohort of mild, asymptomatic dust mite--sensitive asthmatic subjects was identified. Each subject underwent two separate exposures to both 0.4 ppm ozone and clean air in a randomized manner. Nasal lavage was performed before and after each exposure. Nasal allergen was then administered to a defined clinical end point, followed by nasal lavage. Differential cell counts and mast-cell products were identified in each lavage specimen. The mast-cell mediators tryptase and prostaglandin D2 were analyzed, as was a marker of epithelial cell permeability, albumin. Although allergen produced an increase in early-onset mediator release (mast cell-derived), no enhancement was noted after exposure to ozone. Neutrophil and eosinophil inflammatory mediators were not increased after ozone exposure or enhanced after allergen exposure, although ozone did enhance eosinophilic influx after exposure to allergen. Ozone exposure does not promote early-phase--response mediator release or enhance the response to allergen challenge in the nasal airways of extrinsic asthmatic subjects. Ozone, however, may promote an inflammatory cell influx, which helps induce a more significant late-phase response in this population. PMID- 9949358 TI - In vitro testing in pediatric food allergy. AB - Food allergies are an important cause of morbidity in the pediatric population. We used a questionnaire to assess the value of in vitro testing in evaluating children for food allergy. The patient population was divided into two groups: those who tested positive (Class I or greater) for food allergy (combined food/inhalant allergy or food allergy alone) and those who tested negative for food allergy (inhalant only or negative test). Although we recognize that a significant proportion of food allergies may not be IgE-mediated, for the purposes of this study we considered a patient food allergy--positive if in vitro testing was positive and food allergy--negative if testing was negative. Thirty eight of 77 patients tested (49%) were positive for food allergies. Those with food allergies did not have pretreatment scores significantly different from those of patients negative for food allergies (55 vs. 65, p = 0.11). Similarly, we detected no statistically significant difference between the symptom improvement scores of the two groups (37 vs. 40, p = 0.57). We conclude that in vitro testing for food allergies is warranted in children with allergic symptoms, for several reasons: The prevalence of IgE-mediated food allergy in children may be higher than previously thought, and children with food allergies experience the same severity of symptoms as those without. It must be remembered that in vitro testing only detects IgE levels, and therefore a negative test does not mean that the patient does not have food allergies. However, when positive, in vitro testing gives the physician the opportunity to modify the treatment plan, helping avoid time-consuming and demanding oral food challenges. Our questionnaire also showed that food allergy and non-food allergy patients had similar pretreatment and posttreatment symptom scores. PMID- 9949359 TI - Detection of the nasal cycle with acoustic rhinometry: techniques and applications. AB - Acoustic rhinometry is an appropriate method for detecting and recording the nasal cycle in normal subjects in terms of the cross-sectional areas and volume of the nasal cavity. In this study, we tried to detect and to define the nasal cycle in normal subjects so that we might develop a reliable and reproducible technique to be used in conjunction with studies on the physiology and pathology of nasal disease. We used normal volunteer adult subjects and performed bilateral acoustic rhinometry measurements every 15 minutes over 4 hours, along with the use of a visual analog scale for assessment of the subjective feeling of congestion (or patency) just before each acoustic rhinometry measurement. Volume and cross-sectional area changes were observed along with subjective patency score changes in each subject. The subjective feeling of patency was not related to the volume and cross-sectional area changes measured simultaneously. The technique of recording the nasal cycle with acoustic rhinometry in nasal research is presented. PMID- 9949360 TI - Obstructive sleep apnea in children with achondroplasia: surgical and anesthetic considerations. AB - OBJECTIVE: To evaluate the prevalence of obstructive sleep apnea in a large population of children with achondroplasia and to evaluate the effectiveness of adenoidectomy and/or tonsillectomy as treatment. METHODS: Retrospective review of 95 children with achondroplasia. RESULTS: Thirty-six patients (38%) had clinical evidence of obstructive sleep apnea. Thirty-four patients underwent surgery, with more than 1 procedure required in 10 children (29%). Adenotonsillectomy was the initial procedure for 22 of 34 patients, and further therapy was required in only 18% of this group. Adenoidectomy was the initial procedure for 10 of 34, with 90% requiring further surgery for recurrent obstructive sleep apnea. Tonsillectomy alone was performed in 2 patients: 1 was effectively treated and 1 later required adenoidectomy. Endotracheal intubation was accomplished in all patients without complication; 53% required a smaller endotracheal tube than would be predicted by their age. Eight postoperative complications were recorded. CONCLUSIONS: Obstructive sleep apnea is very common in children with achondroplasia. Surgery is effective, but recurrent symptoms are common, particularly when the initial procedure is adenoidectomy. The complication rate is higher than that observed in a general pediatric population but is readily managed with standard therapy. Anesthesia can be given safely to these patients with special consideration for limited neck extension and appropriate endotracheal tube size. PMID- 9949361 TI - Association of adhesive macromolecules with terminal sprouts at the neuromuscular junction after botulinum treatment. AB - Small quantities of botulinum toxin (BTX) are useful in the treatment of certain movement disorders, such as laryngeal spasmodic dysphonia, blepharospasm, and cervical dystonia. However, the corrective paralytic effects of BTX are only temporary, in part because of the formation of remodeled neuromuscular junctions. Here, we questioned whether various factors within and near the neuromuscular junction could contribute to the remodeling seen after BTX treatment. BTX was injected subcutaneously in the region of the levator auris longus muscle. At 1 week intervals, levator auris longus muscles were removed and examined histochemically. As previously described, BTX treatment results in a progressive elongation of end plates. The neural cell adhesion molecule was not associated with the elongated end plates but was associated with the BTX-induced nerve sprouts after long intervals (3 to 4 weeks). Similarly, after BTX, laminin-1 (composed of alpha 1, beta 1, and gamma 1 chains) reactivity was associated with the nerve sprouts, but not with the end plates. Laminin beta 2 reactivity at the end plate dispersed somewhat within 1 week but remained diffusely associated with the elongating end plates for up to 5 weeks. Together these results suggest that neural cell adhesion molecule and laminins may participate in the sprouting observed after BTX treatment and that alterations in laminin beta 2 expression may participate in initial loss of contacts. PMID- 9949362 TI - Effects of estrogen and tamoxifen on growth of human vestibular schwannomas in the nude mouse. AB - Vestibular schwannomas have been noted to have increased frequency and aggressivity in female patients, suggesting a possible role of estrogen. This study evaluated the effects of estrogen and tamoxifen on the growth of human vestibular schwannoma tissue implanted in subcutaneous pockets of nude mice. Animals were implanted with 1 of 3 human vestibular schwannomas and observed for 28 days. Mice were then separated into 3 treatment groups: controls, estrogen (receiving 1.7 mg of 17B-estradiol), and estrogen + tamoxifen (receiving 1.7 mg of 17B-estradiol + 10 mg of tamoxifen), and treated for 28 days. Mice treated with estrogen showed increased growth that was statistically significant (P < 0.05) when compared with that of both the controls and the animals treated with estrogen + tamoxifen. Controls and animals treated with estrogen + tamoxifen showed a general trend of decreased volume during the treatment period. These early results support the hypothesis that estrogen modulates the growth of vestibular schwannomas in the nude mouse model and that these effects can be blocked by tamoxifen administration. PMID- 9949363 TI - Multiple otopathologic disorders: a diagnostic dilemma. PMID- 9949364 TI - Seasonal patterns of idiopathic facial paralysis: a 16-year study. AB - The annual frequency of Bell's palsy in 16 consecutive years was investigated in a 465,000-person health area in Madrid, Spain. The annual incidence of Bell's palsy per 100,000 population was found to be 24.1. The male-to-female ratio was 46:54. Seasonal difference in the incidence was noted in our series with fewer cases during summer. According to these results, the illness in Spain seems to have a similar incidence to that in Western countries. In addition to this, Bell's palsy does not have an infectious epidemiologic pattern in our country, but its frequency decreases in warm weather. PMID- 9949366 TI - Medialization laryngoplasty. AB - Medialization laryngoplasty was performed in 25 patients between 1993 and 1997. The underlying pathology resulting in glottal incompetence was vocal cord paralysis in 22 patients and vocal cord bowing in 3 patients. Two types of implants were used: self-carved Proplast in 19 patients and prefabricated hydroxyapatite prostheses in 6 patients. Preoperative and postoperative results were compared in terms of dysphagia, vocal quality as graded by three experienced voice specialists, and computer measurements of the glottal gap. All patients showed improvement both subjectively and on the objective measurements used. Swallowing returned to normal in all patients who had isolated recurrent laryngeal nerve paralysis. The voice improved in all patients but was rarely judged as entirely normal. PMID- 9949365 TI - Effect of parenteral pentoxifylline and topical nitroglycerin on skin flap survival. AB - Flap necrosis is still a significant complication in all types of flap surgery. The effect of parenteral pentoxifylline and nitroglycerin in improving survival of ischemic skin flaps was tested in Wistar rats. In the control group (n = 15) the mean viable length of the flaps was calculated to be 6.160 +/- 0.936, and nonnecrotic flap area was found to be 1859.1 +/- 269.3. In the group treated with pentoxifylline and nitroglycerin (n = 15), the mean viable length of the flap was calculated to be 6.907 +/- 0.617, and the mean nonnecrotic flap area was found to be 2078.5 +/- 172.7. In this study results showed that the use of parenteral pentoxifylline and topical nitroglycerin is effective on skin flap survival. PMID- 9949367 TI - Microbiology of sinusitis in patients undergoing bone marrow transplantation. AB - As a result of increasing use of bone marrow transplantation and new cytotoxic chemotherapy, more patients have become susceptible to sinus disease caused by unusual organisms. Sinusitis caused by fungi and gram-negative bacteria can be difficult to treat, may lead to severe complications, and should be managed promptly in the bone marrow transplant patient. Here we present the results of 41 cultures of the paranasal sinuses obtained from 18 bone marrow transplant patients in whom sinusitis developed. The most common agents were gram-negative bacteria (56.7%), followed by gram-positive bacteria (26.7%) and fungi (16.6%). In 13 samples the cultures were negative. Nasal cultures were performed ipsilateral to the sinus drained in 28 cases. Concordance was obtained in only 5 (17.8%) samples. The antibiogram of the isolated agents from the maxillary sinuses in this series revealed that the most efficient antibiotics were those that covered gram-negative bacteria. Treatment was usually prolonged in these patients, and different antibiotics were necessary to clear infections from the sinuses. In conclusion, treating sinusitis in bone marrow transplant patients may be challenging. Considerations about the microbiology and antibiogram susceptibilities of this specific population should be kept in mind when dealing with such cases. PMID- 9949368 TI - Fibrous dysplasia as a cause of periorbital abscess. PMID- 9949369 TI - Merkel cell carcinoma of the pinna. PMID- 9949370 TI - Amyloidosis of the palate. PMID- 9949371 TI - Infection control in long-term care: news from the front. PMID- 9949372 TI - Infection control programs in skilled nursing long-term care facilities: an assessment, 1995. AB - BACKGROUND: In 1989 the Health Care Financing Administration mandated that long term care facilities (LTCFs) maintain infection control programs; however, few data are available to guide the design of these programs. The purpose of this study was to assess the current status of infection control programs in LTCFs by using methodology adapted from Phase I of the Centers for Disease Control and Prevention Study on the Efficacy of Nosocomial Infection Control. METHODS: A descriptive study of infection control programs in skilled nursing LTCFs was undertaken in a representative sample of 136 New England skilled nursing LTCFs that have >/=25 beds, with use of a self-report Infection Surveillance and Control Questionnaire. RESULTS: Nearly all (98%) the LTCFs reported having personnel responsible for infection control, with a median of 8 hours per week spent on infection control activities. Ninety percent of these persons were registered nurses; 52% had formal training in infection control. Twenty-five percent of the respondents reported that their infection control program was either "inactive" or nonexistent in 1988, and 60% rated their programs as either "moderately active" (43%) or "very active" (17%) during that year. By 1994, most LTCFs (67%) rated themselves as "very active," and only 3% as inactive or nonexistent. The mean scores on the questionnaire's surveillance and control indices were 23 (out of a possible 30) and 47 (out of a possible 60), respectively, which indicates medium infection surveillance and control activity. On the basis of the data provided by 72% of the respondents (n = 98), a crude estimate of 13.97 infections per 1000 resident-days was calculated, which is a higher rate than previously reported for LTCFs. CONCLUSIONS: Findings from the study indicate that it is feasible to use methodology adapted from Phase I of the Centers for Disease Control and Prevention Study on the Efficacy of Nosocomial Infection Control to assess infection control programs in LTCFs; however, further research into the efficacy of nosocomial infection control in skilled nursing LTCFs is needed. PMID- 9949373 TI - Antimicrobial prescribing in long-term care facilities: prospective evaluation of potential antimicrobial use and cost indicators. AB - BACKGROUND: Few studies exist regarding methods of monitoring antimicrobial prescribing in the long-term care setting. METHODS: Data were collected monthly in 4 long-term care facilities (LTCFs) for 20 to 26 months. The data included incidence (No. of antimicrobial courses started per 1000 resident care days) of antimicrobial use, antimicrobial utilization ratio (ratio of the number of antimicrobial-days to the number of resident care days), cost of antimicrobial day, and cost of therapy per resident care day. In one facility, physician specific data were also collected. RESULTS: Seasonal variation in the incidence of antimicrobial use was identified, with the highest rates occurring in the winter months. Significant differences in the mean incidence of antimicrobial use, mean antimicrobial utilization ratio, mean cost per antimicrobial-day, and mean cost per resident care day were identified among the 4 LTCFs during the study period. A significant correlation existed between incidence of antimicrobial use or antimicrobial utilization ratio and the overall infection rate or site-specific rates when the data from all 4 LTCFs were aggregated for analysis. Monthly variation in cost per antimicrobial-day was best explained by the monthly variation in prescribing of high-cost (>$15 per day) agents. With these same parameters for use and cost, considerable variation in prescribing and cost of therapy was noted among 7 physicians in the same facility. CONCLUSIONS: The parameters evaluated detected significant differences in prescribing and cost of antimicrobials among 4 LTCFs. If these findings are verified in larger studies, these parameters may be useful for monitoring trends in prescribing and for interfacility comparisons after adjustment for case-mix differences. PMID- 9949375 TI - Joint Commission standards for long-term care infection control: putting together the process element. Joint Commission on Accreditation of Healthcare Organizations. AB - Infection control in long-term care is being recognized more and more as the essential entity it has always been. As a surveyor for the long-term care program of the Joint Commission on Accreditation of Healthcare Organizations, I have noted that some confusion exists in the field as to what aspects of an infection control program are to be surveyed at specific standards. The standards are designed to allow flexibility to ensure that infection control programs meet the specific needs of the resident population and that these programs can continue to evolve. This article attempts to provide some clarity for the infection control professionals who are preparing for Joint Commission survey. PMID- 9949374 TI - Regional data set of infection rates for long-term care facilities: description of a valuable benchmarking tool. AB - BACKGROUND: Surveillance for nosocomial infections has been clearly established as a key element of all infection control programs. Surveillance programs in long term care facilities (LTCFs) have been described, but published infection rates vary widely depending on the type of facility studied, nature of resident population, definitions used for LTCF-acquired infections, and type of data analysis. The aim of this initial study was to create a standardized regional data set of infection rates that could provide an external benchmark for interfacility comparison. METHODS: The study included 6 LTCFs in close geographic proximity with similar patient populations. Surveillance in each facility was conducted by a licensed nurse supervised by an infectious diseases physician. Standard definitions for infections and uniform reporting forms were used. Data were pooled in an aggregate cumulative fashion, and data analysis was patterned after the National Nosocomial Infection Surveillance System. RESULTS: The data set consisted of 328,065 resident-days of care during 30 months, with a total of 1252 infections for a pooled mean rate of 3.82 infections per 1000 resident-days of care. Infections for specific categories were 496 urinary tract infections (rate 1.51), 376 respiratory tract infections (rate 1.15), 88 gastroenteritis infections (rate 0.27), 283 skin and soft tissue infections (rate 0.86), 2 bloodstream infections (rate 0.06), and 3 unexplained febrile illnesses (rate 0. 09). Data analysis for comparison included interfacility means +/-2 standard deviations and percentiles of distribution. CONCLUSIONS: A regional data set of infection rates for LTCFs allowed for meaningful interfacility comparison of overall and specific endemic rates and is a valuable benchmarking tool for participating facilities. PMID- 9949376 TI - Guide to writing for publication in AJIC: American Journal of Infection Control. PMID- 9949377 TI - APIC position paper: immunization. Association for Professionals in Infection and Epidemiology, Inc. AB - The Association for Professionals in Infection Control and Epidemiology, Inc. (APIC) is a multidisciplinary organization of more than 11,000 health care professionals who practice infection control and epidemiology within a variety of health care settings. As an authority in infection control, APIC endorses the Advisory Committee on Immunization Practices (ACIP) recommendations that are published by the Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report. APIC supports the immunization initiative of the Healthy People 2000: National Health Promotion and Disease Prevention Objectives, which contains a national strategy for significantly improving the health of the nation, including preventing infectious diseases through immunization. PMID- 9949379 TI - APIC position paper: responsibility for interpretation of the PPD tuberculin skin test. Association for Professionals in Infection Control and Epidemiology, Inc. AB - The Association for Professionals in Infection Control and Epidemiology, Inc (APIC) is a multidisciplinary, voluntary, international organization of professionals who practice infection control and the application of epidemiology in all health settings. APIC is an international leader in prevention and control of infection transmission. PMID- 9949378 TI - APIC position paper: hepatitis C exposure in the health care setting. Association for Professionals in Infection Control and Epidemiology, Inc. AB - The Association for Professionals in Infection Control and Epidemiology, Inc (APIC), is a multidisciplinary, voluntary, international organization of professionals who practice infection control and the application of epidemiology in all health settings. APIC is an international leader in prevention and control of infection transmission. PMID- 9949380 TI - Faucet aerators: A source of patient colonization with Stenotrophomonas maltophilia. AB - BACKGROUND: Multiple nosocomial outbreaks have been linked to contaminated water sources within the hospital. We report in this article a cluster of patients in a surgical intensive care unit who were colonized or infected with Stenotrophomonas maltophilia. METHODS: This study was conducted at an acute care academic hospital. Patients colonized or infected with S maltophilia were identified by prospective surveillance. Environmental isolates were obtained by culturing multiple water sources by using standard techniques. Patient and environmental isolates were examined by pulsed-field gel electrophoresis. RESULTS: Patients were colonized with 2 isolates of S maltophilia, which were found by pulsed-field gel electrophoresis to be identical to strains isolated from the faucet aerators present in sinks in the patients' rooms. Multiple different strains, as defined by pulsed-field gel electrophoresis, were isolated from patients during this outbreak. CONCLUSIONS: We believe that low level contamination of our potable water led to contamination of the faucet aerators with subsequent bacterial amplification on the aerator, which led to contamination of water after aeration. Cultures should be performed on faucet aerators when water sources are suspected as the reservoir for a nosocomial outbreak. If additional clusters of infected or colonized patients are linked to contaminated aerators, consideration should be given to routine disinfection or removal of the aerators. PMID- 9949381 TI - Team approach to infection prevention and control in the nursing home setting. PMID- 9949382 TI - Efficacy of triclosan. PMID- 9949386 TI - Phenotypic and genotypic heterogeneity in familial Milroy lymphedema. AB - Familial Milroy lymphedema (ML) is classified as an autosomal dominant disorder characterized by peripheral edema of the lower extremities at birth or in early childhood. The variety of phenotypes are not well described, and the genomic location and functional expression of the gene or genes underlying this and related familial lymphedema syndromes remain largely unknown. In this collaborative study between the University of Arizona and the University of Sao Paulo, we collected clinical pedigrees on 6 ML families, carried out clinical examination of affected and unaffected individuals, and, in representative affected members of two of the families performed dynamic lymphangioscintigraphy (LAS) of the lower and upper limbs to delineate further the ML lymphangiodysplastic phenotype. To localize the gene for ML, we conducted a genome-wide search in 4 of the families using 387 polymorphic dinucleotide-repeat markers at approximate 10 cM spacing in 54 subjects (affected, unaffected bloodline relatives, and spouses). In all 6 families (86 subjects), we specifically examined the suggested linkage to the vascular endothelial growth factor (VEGF)-C receptor (Flt4) gene localized to the chromosome region 5q34-q35. The findings provide evidence for a spectrum of ML clinical and LAS phenotypes and also suggest ML locus heterogeneity. PMID- 9949387 TI - Liposuction reduces arm lymphedema without significantly altering the already impaired lymph transport. AB - In a prospective study, 20 patients with arm lymphedema after breast cancer treatment underwent liposuction combined with Controlled Compression Therapy (CCT) or CCT alone. Indirect lymphoscintigraphy (ILS) was used to study lymph kinetics before and after intervention. Lymphoscintigrams from the contralateral, non-edematous arm were characterized by prompt transit of the radiotracer (99mTc albumin nanocolloid) to the axillary nodes, whereas tracer accumulation as dermal backflow characterized tracer transport in the lymphedematous arm. Neither liposuction with CCT nor CCT alone, changed this ILS profile. Liposuction combined with CCT reduced arm edema volume by (median) 115% (range 92-179%), whereas CCT alone decreased arm edema volume by only 54% (range 7-81%) (p = 0.008). Because liposuction in conjunction with CCT was not associated with further impairment to an already restricted lymph transport, we recommend this therapy (liposuction with external compression) for chronic arm lymphedema, as it reduces edema volume safely, rapidly, and more efficiently than external compression alone. Moreover, it does not worsen an already impaired lymph transport in the lymphedematous upper extremity. PMID- 9949388 TI - Changes of tissue fluid hyaluronan (hyaluronic acid) in peripheral lymphedema. AB - Hyaluronan (hyaluronic acid or HA) is an important component of the extracellular matrix which is synthesized in the tissue, transported in lymph and catabolized mainly in lymph nodes and the liver. In 39 patients with chronic peripheral lymphedema, the HA content in lymphedematous interstitial fluid was measured using radioimmunoassay. For comparison, the concentration of HA in serum and normal tissue fluid were also determined. These samples were also tested for protein concentration. The results showed that the HA concentration in interstitial fluid of a lymphedema limb was 22 x 10(3) +/- 10(3) (aspiration) and 30 x 10(3) +/- 4 x 10(3) (wick) ng/ml which were significantly higher than that in interstitial fluid, serum and lymph of normal limbs (control) and interstitial fluid of limbs with venous edema (p < 0.001). The protein concentration in these fluids did not show significant differences between lymphedema and those with normal limbs. The findings suggest that HA stagnates in the limb with impaired lymph drainage which may exert a deleterious effect on the interstitium. PMID- 9949389 TI - Transaxial computer tomography of lower extremity lymphedema. AB - We examined retrospectively 11 patients with isolated unilateral lower limb lymphedema (clinical criteria confirmed by isotope lymphography) using computer tomography. In conjunction with earlier observations, the findings of soft tissue stranding, skin thickening, fat deposition in the epifascial compartment and perimuscular fascial thickening and edema relate to lymph stasis. This noninvasive and relatively simple imaging technique allows analysis of soft tissue changes in leg lymphedema and can be used to evaluate lymphatic insufficiency and its extent as well as document the response to treatment. PMID- 9949390 TI - Levels of eicosanoids (6-oxo-PGF1 alpha and 8-epi-PGF2 alpha) in human and porcine lymphatics and lymph. AB - Prostaglandin (PG)I2 is the primary eicosanoid synthesized by human lymphatics and 8-epi-PGF2 alpha, an isoprostane formed during free radical catalyzed peroxidation, is the most potent stimulator of lymphatic contraction tested thus far. We now examine the respective concentrations in the lymphatic wall of both human and porcine lymphatics and lymph fluid using specific immunoassays. Although both compounds are detectable in the lymphatic wall and lymph fluid, PGI2- (via its main metabolite 6-oxo-PGF1 alpha) is greater in the lymphatic wall whereas 8-epi-PGF2 alpha dominates in lymph fluid. Because inflammation is associated with oxidative injury, which in turn stimulates release of isoprostane, eicosanoid derivatives may modulate lymphatic tone during acute tissue reaction. PMID- 9949392 TI - In the next decade automated computer analysis will be an accepted sole method to separate "normal" from "abnormal" radiological images. PMID- 9949391 TI - Excision of subcutaneous tissue and deep muscle fascia for advanced lymphedema. AB - In advanced peripheral lymphedema particularly involving the legs, complex physical therapy (massage/bandage-wrapping compression, remedial exercises, and maintenance use of a low stretch elastic compression garment), is not uniformly successful. In six patients with morbid lymphedema of the legs, we described our positive experience using a modified Auchincloss/Homans excisional operation. PMID- 9949393 TI - Multi-slice helical CT: scan and reconstruction. AB - The multi-slice CT scanner refers to a special CT system equipped with a multiple row detector array to simultaneously collect data at different slice locations. The multi-slice CT scanner has the capability of rapidly scanning large longitudinal (z) volume with high z-axis resolution. It also presents new challenges and new characteristics. In this paper, we study the scan and reconstruction principles of the multi-slice helical CT in general and the 4 slice helical CT in particular. The multi-slice helical computed tomography consists of the following three key components: the preferred helical pitches for efficient z sampling in data collection and better artifact control; the new helical interpolation algorithms to correct for fast simultaneous patient translation; and the z-filtering reconstruction for providing multiple tradeoffs of the slice thickness, image noise and artifacts to suit for different application requirements. The concept of the preferred helical pitch is discussed with a newly proposed z sampling analysis. New helical reconstruction algorithms and z-filtering reconstruction are developed for multi-slice CT in general. Furthermore, the theoretical models of slice profile and image noise are established for multi-slice helical CT. For 4-slice helical CT in particular, preferred helical pitches are discussed. Special reconstruction algorithms are developed. Slice profiles, image noises, and artifacts of 4-slice helical CT are studied and compared with single slice helical CT. The results show that the slice profile, image artifacts, and noise exhibit performance peaks or valleys at certain helical pitches in the multi-slice CT, whereas in the single-slice CT the image noise remains unchanged and the slice profile and image artifacts steadily deteriorate with helical pitch. The study indicates that the 4-slice helical CT can provide equivalent image quality at 2 to 3 times the volume coverage speed of the single slice helical CT. PMID- 9949394 TI - Moving segments region of interest attenuator for x-ray fluoroscopy. AB - Region of interest (ROI) imaging has previously been proposed as a means of reducing x-ray fluoroscopy radiation dose. Previous ROI attenuators made of partially attenuating metal plates change beam quality, which may lead to uncertainty in image restoration procedures. The design and construction of a prototype moving segments ROI attenuator (MS-ROI), which maintains beam quality across the whole field of view is described. The x-ray beam intensity is halved by 36 lead segments which are rapidly rotated between the x-ray tube and patient, with a central hole projecting a circular ROI at full intensity. Image processing techniques with automatic detection of the ROI boundary were used to homogenize image brightness across the whole image. Images restored using these techniques were judged to be visually acceptable, with a good match between pixel values inside and outside the ROI. Image contrast within the ROI was improved by 18% due to reduced scatter and veiling glare from the periphery. The introduction of the MS-ROI attenuator also results in a 48% increase in statistical noise in the area outside the ROI, with no significant change in object contrast. The patient entrance dose measured using the dose area product (DAP) method was reduced by 53.4% under manual exposure control, with the dose to operators reduced by 48.4% under automatic brightness control. Further work is needed to determine whether the attenuator can be used with pulsed fluoroscopy, and to reduce vibrational effects on the ROI boundary. The MS-ROI attenuator provides a more constant ratio of central-to-peripheral image intensity, and maintains uniform beam quality and image contrast across the whole image in comparison to simple metal plate attenuators. PMID- 9949395 TI - Performance characteristics of a Kodak computed radiography system. AB - The performance characteristics of a photostimulable phosphor based computed radiographic (CR) system were studied. The modulation transfer function (MTF), noise power spectra (NPS), and detective quantum efficiency (DQE) of the Kodak Digital Science computed radiography (CR) system (Eastman Kodak Co.-model 400) were measured and compared to previously published results of a Fuji based CR system (Philips Medical Systems-PCR model 7000). To maximize comparability, the same measurement techniques and analysis methods were used. The DQE at four exposure levels (30, 3, 0.3, 0.03 mR) and two plate types (standard and high resolution) were calculated from the NPS and MTF measurements. The NPS was determined from two-dimensional Fourier analysis of uniformly exposed plates. The presampling MTF was determined from the Fourier transform (FT) of the system's finely sampled line spread function (LSF) as produced by a narrow slit. A comparison of the slit type ("beveled edge" versus "straight edge") and its effect on the resulting MTF measurements was also performed. The results show that both systems are comparable in resolution performance. The noise power studies indicated a higher level of noise for the Kodak images (approximately 20% at the low exposure levels and 40%-70% at higher exposure levels). Within the clinically relevant exposure range (0.3-3 mR), the resulting DQE for the Kodak plates ranged between 20%-50% lower than for the corresponding Fuji plates. Measurements of the presampling MTF with the two slit types have shown that a correction factor can be applied to compensate for transmission through the relief edges. PMID- 9949396 TI - Signal formation and decay in CdTe x-ray detectors under intense irradiation. AB - The response of Cd(Zn)Te Schottky and resistive detectors to intense x-rays is investigated in a commercial computed tomography (CT) system to assess their potential for medical diagnostics. To describe their signal height, responsivity, signal-to-noise ratio (SNR), and detective quantum efficiency the devices are modeled as solid-state ionization chambers with spatially varying electric field and charge collection efficiency. The thicknesses and pixel areas of the discrete detector elements are 0.5-2 mm and a few mm2, respectively. The incident spectrum extends from 26 to 120 keV and comprises 10(10) quanta/s cm2. It photogenerates a carrier concentration in the semiconductor that is two to three orders of magnitude above the intrinsic concentration, but remains to a similar extent below the charge densities on the device electrodes. Stable linear operation is achieved with the Schottky-type devices under high bias. Their behavior can be modeled well if negatively charged near-midgap bulk defects with a concentration of 10(11)-10(13) cm-3 are assumed. The bulk defects explain the amount and time constant (about 100 ms) of the detrapping current measured after x-ray pulses (afterglow). To avoid screening by the trapped space charge the bias voltage should exceed 100(V) x [detector thickness/mm]2. Dark currents are of the order of the generation-recombination current, i.e., 300 pA/mm3 detector volume. With proper device design the signal height approaches the theoretical maximum of 0.2 A/W. This high responsivity, however, is not exploited in CT since the SNR is determined here by the incident quantum noise. As a consequence of the detrapping current, the response speed does not meet CT requirements. A medium-term effort for crystal growth appears necessary to achieve the required reduction of the trap density by an order of magnitude. Scintillation based detectors are, therefore, still preferred in fast operating medical diagnostic systems. PMID- 9949397 TI - Method for determining photonuclear production of radioisotopes using high-energy electron beams. AB - Linear accelerators can produce electrons at high power and energy. These electrons can be targeted at materials to produce radionuclides. Monte Carlo simulation is used to follow the path of the linac electrons (15-35 MeV) through materials. The production of photons and their passage through the material is modeled. The method of using this Monte Carlo information to calculate activation in the materials is presented. It is found that kilowatt power levels can produce mCi amounts of radioactivity in minutes. This work permits systematic evaluation of the potential for designing linear accelerators for in-house production of radionuclides. PMID- 9949398 TI - Characterization of the output for helical delivery of intensity modulated slit beams. AB - The UW tomotherapy workbench utilizes a convolution/superposition based dose calculation and optimization program. It specifies the energy fluence that must be delivered from each leaf for each phantom projection angle. This requires that the spectrum of the radiation emitted from the one-dimensional MLC (multileaf collimator) attached to the linear accelerator be determined. The steps involved in that process are described. The spectrum along the central axis of the slit beam was determined, as well as the softening with off-axis position. Moreover, the magnitude of the energy-fluence output had to be quantified on a per MU (monitor unit) basis. This was done for a single leaf along the central axis of the beam. Factors, which modify that energy-fluence output, were investigated. The output increases with off-axis position due to the horns of the beam. The output for a leaf of interest will also increase if additional leaves are open due to the absence of the tongue-and-groove effect and penumbra blurring. The energy-fluence increase per leaf increase by 4.9% if an adjacent leaf is open. No other factors related to the state of additional leaves were found to significantly increase the energy-fluence output for an individual leaf. PMID- 9949399 TI - Physical characteristics of a miniature multileaf collimator. AB - A preliminary study of the physical characteristics of a miniature multileaf collimator (mMLC) used with 4 MV x rays is reported. The mMLC attached to the accessory mount of a class C or D Varian linear accelerator (Varian Oncology Systems, Palo Alto, CA) with a source to aperture distance of 65 cm. The field penumbra using the small leaves was found to be consistent with the anticipated field penumbra using photon jaws at the same source to aperture distance as the mMLC. The percentage depth dose values of square fields were found to be consistent with the fields collimated with the upper and lower jaws. Output factors for the very small fields were found to vary rapidly. Circular fields could be produced with depth dose characteristics similar to those produced using conical tertiary collimators, commonly used for radiosurgery, but with a broader penumbra. PMID- 9949400 TI - Design for an accelerator-based orthogonal epithermal neutron beam for boron neutron capture therapy. AB - This paper is concerned with the proposed Birmingham accelerator-based epithermal neutron beam for boron neutron capture therapy (BNCT). In particular, the option of producing a therapy beam at an orthogonal direction to the incoming protons is considered. Monte Carlo radiation transport simulations, both with and without a head phantom, have shown that an orthogonal beam geometry is not only acceptable but is indeed beneficial, in terms of a lower mean neutron energy and an enhanced therapeutic ratio for the same useful neutron fluence in the therapy beam. Typical treatment times for various beam options have been calculated, and range from 20 to 48 min with a 5 mA beam of 2.8 MeV protons, if the maximum photon equivalent dose delivered to healthy tissue is to be 12.6 Gy Eq. The effects of proton beam diameter upon the therapy beam parameters have also been considered. PMID- 9949401 TI - Toward a final design for the Birmingham boron neutron capture therapy neutron beam. AB - This paper is concerned with the proposed Birmingham accelerator-based epithermal neutron beam for boron neutron capture therapy (BNCT). Details of the final moderator design, such as beam delimiter, shield, and beam exit surface shape are considered. Monte Carlo radiation transport simulations with a head and body phantom have shown that a simple flat moderator beam exit surface is preferable to the previously envisioned spherical design. Dose rates to individual body organs during treatment have been calculated using a standard MIRD phantom. We have shown that a simple polyethylene shield, doped with natural lithium, is sufficient to provide adequate protection to the rest of the body during head irradiations. The effect upon the head phantom dose distributions of the use of such a shield to delimit the therapy beam has been evaluated. PMID- 9949402 TI - Experimental determination of the thermal neutron flux around two different types of high intensity 252Cf sources. AB - The application of neutron emitting radioisotopes in brachytherapy facilitates the use of the higher biological effectiveness of neutrons compared to photons in treating some cancers. Different types of high intensity 252Cf sources are in use for the treatment of different cancers. To improve the therapy of bulky tumors the dose can be augmented by the additional use of the boron capture reaction of thermal neutrons. This requires information about the thermal neutron dose component around the Cf source. In this work, a Mg/Ar-ionization chamber internally coated with 10B was used to measure the thermal neutrons. These measurements were performed on two different 252Cf sources, one in use in the Gershenson Radiation Oncology Center at Harper Hospital in Detroit, MI, and one at the University Hospital of Chiang Mai in Chiang Mai, Thailand. The results of these measurements are compared and indicate that the differences in the construction of the sources influence the thermal dose component. PMID- 9949403 TI - Clinical brachytherapy with neutron emitting 252Cf sources and adherence to AAPM TG-43 dosimetry protocol. AB - Using Monte Carlo methods, neutron dosimetry for 252Cf Applicator Tube (AT) type medical sources available from Oak Ridge National Laboratory (ORNL) has for the first time been determined in terms of TG-43 formalism. This approach, as compared to previous "along-away" formalisms, demonstrates the relative angular independence of dose rate data, when the geometry factor has been removed. As the ORNL-made 252Cf AT type sources are considerably physically larger than most clinical sources used today, the radial dose function increases for radii less than 3.0 mm due to breakdown of the line source model. A comparison of the 252Cf neutron radial dose function with those for other medical sources revealed similarities with that from 137Cs. Differences with respect to previous 252Cf AT source neutron dosimetry data generally increased at increasing distances. This was attributed to differences in the various 252Cf AT source models and phantom compositions. The current status of 252Cf medical source fabrication and calibration procedures at ORNL is presented. PMID- 9949404 TI - Scatter and attenuation measurements at distances greater than 10 cm from an 192Ir source. AB - Most algorithms developed by various investigators for use in brachytherapy treatment planning have typically been designed to calculate the dose within a 10 cm range of a radiation source. These algorithms predict the dose well at distances < 10 cm from the source but were not developed and should not be utilized to predict the dose at distances > 10 cm. On the contrary, treatment planning systems and manual calculations will produce erroneous results when dose points > 10 cm are calculated using these algorithms. The spread in the data generated by the above algorithms is 16% at 15 cm and 42% at 20 cm. Physical measurements were performed at distances between 5 and 50 cm from a high activity 192Ir source in water. The measured data correlated well with the predicted data from 5 to 10 cm, which had a 5% spread. Beyond 10 cm the measured data fell central to the range of the predicted data, with the spread of the predicted data increasing from 5% to 80% with increasing distance from the source. The measured data was fitted with a model incorporating a buildup factor and an attenuation factor. The best fit values are in reasonable agreement with those obtained by two of the investigators, Thomason and Tripathi. PMID- 9949405 TI - Commissioning a p-type silicon diode for use in clinical electron beams. AB - Commissioning measurements were carried out on a p-type silicon diode detector for use in patient monitoring in high energy electron beams. Characteristics specific to the diode were examined. The variation in diode sensitivity with dose per pulse was found to be less than 1% over a range 0.069-0.237 mGy/pulse. The diode exhibited a sensitivity variation with accumulated dose of 10% per kGy and a sensitivity variation with surface temperature of 0.26%/degree C. The dependence of the diode response on the direction of the incident electron beam was investigated. Results were found to exceed the manufacturer's specifications. Output factors measured with the diode agree to within 1.5% of those measured with an NACP-02 air ionization chamber. The detector showed a variation in response with energy of 0.8% over the energy range 4-15 MeV. Prior to introducing the diode into clinical use, an assessment of beam perturbation directly behind the diode was made. The maximum reduction in local dose directly behind the diode at a depth of 1.0 cm below the surface was approximately 13% at 4 and 15 MeV. PMID- 9949406 TI - Bad blood and biologicals: the need for new radiopharmaceutical source materials. PMID- 9949407 TI - PET imaging using dual-headed gamma cameras: an update. AB - Interest in clinical fluorodeoxyglucose (FDG) imaging with dual-headed gamma cameras continues to grow. In 1996, Jarritt and Acton published a review article of the use of gamma-camera systems for FDG imaging [1]. Since that article was published, considerable progress has been made in the adaptation of dual-headed camera systems for coincidence imaging. We review the basic principles of dual headed coincidence imaging and some of the major limitations and challenges in the development of such technology. Since much of the current clinical experience with FDG imaging is based on the use of dedicated position emission tomographic (PET) systems, some comparisons of the performance limitations between dual headed gamma-camera and dedicated PET systems are provided. PMID- 9949408 TI - Whole-body 18F-FDG PET for the evaluation of patients with Hodgkin's disease and non-Hodgkin's lymphoma. AB - Whole-body metabolic information provided by 18F-FDG PET could help in the evaluation of lymphoma patients at diagnosis and follow-up. We studied 60 patients, 42 at initial presentation and 18 for disease recurrence (23 aggressive non-Hodgkin's lymphoma, 21 low-grade non-Hodgkin's lymphoma and 16 Hodgkin's disease). All patients underwent a clinical examination, computed tomography (CT) and a non-attenuated PET scan within 1 week. The patients received 222-296 MBq (6 8 mCi) 18F-FDG intravenously and emission scans were recorded 45-90 min later. 18F-FDG PET detected more lymph nodes than the clinical examination or CT, but this rarely resulted in upstaging (two patients). The concordance between PET and CT for the evaluation of the spleen, liver and digestive tract was quite good. Discordance was noted in 12 patients for the evaluation of bone marrow infiltration, but confirmation by MRI or focal biopsy was not always obtained. We conclude that non-attenuated 18F-FDG PET is an easy and efficient whole-body method for the evaluation of patients with lymphomas. Compared with conventional techniques, however, it does not appear to offer much improvement for staging but provides a satisfactory base for follow-up. PMID- 9949409 TI - The practice of medical and surgical synovectomy: a UK survey. AB - Radiation, chemical and surgical synovectomy are therapeutic options in the treatment of chronic synovitis, but the evidence for their efficacy is limited. The aim of this survey was to compare the frequency of, and the factors affecting the use of, the three types of synovectomy in the last 2 years in the UK. Questionnaires were sent to all consultant rheumatologists and orthopaedic surgeons in the UK. Completed questionnaires were received from 294 rheumatology and 832 orthopaedic NHS consultants currently practising in the UK. Replies from the rheumatologists showed that surgical synovectomy was used most frequently, followed by radiation synovectomy (175 and 160 consultants respectively). Only 33 consultants had used chemical synovectomy. Only 314 of the 832 (38%) orthopaedic consultants who replied had performed surgical synovectomies in the last 2 years; 195 had used an arthroscopic procedure and 193 an open procedure. For all three therapies, the knee was the most commonly treated joint. PMID- 9949410 TI - Detection of CBF deficits in neuropsychiatric disorders by an expert system: a 99Tcm-HMPAO brain SPET study using automated image registration. AB - The aims of this study were to develop an objective method for assessing rCBF deficits using a statistical image analysis protocol and to validate its effective use in clinical practice. 99Tcm-HMPAO brain SPET images were acquired for 40 normal subjects, 10 patients with Alzheimer's disease and 10 patients with depression. Automated image registration was used to standardize the size and shape of the brain structures for all subjects. The images of the first 30 normal subjects were used to construct a normal database. The CBF images of the other 10 normal subjects and the 20 patients were compared voxel by voxel with the normal database to map CBF abnormalities by statistical evaluation. The results were compared with the clinical reports of CBF images. The expert system detected all rCBF deficits reported by the nuclear physicians. Some additional areas with special information, like atrophy and bilateral asymmetry, were also identified by the expert system. We conclude that this expert system can delineate CBF deficits with sufficiently high accuracy, differentiating normal from abnormal CBF images using voxel-based comparisons. The use of an expert system improves rCBF SPET image evaluation. PMID- 9949411 TI - Variability study of a non-invasive approach to the absolute quantification of cerebral blood flow with 99Tcm-ECD using aortic activity as the arterial input estimate. AB - The absolute measurement of regional cerebral blood flow can be made non invasively if dynamic scanning is performed immediately following the intravenous injection of 99Tcm-labelled HMPAO or ECD. By application of an elementary one step kinetic model in which the arterial input curve is estimated from a region of interest over the anterior aortic arch projection, a brain perfusion index (BPI) can be calculated which is correlated to the total hemispheric blood flow. The aim of this study was to assess the variability of the BPI approach as applied to the calculation of cerebral blood flow. For 46 patients (30 men, 16 women) aged 23.7-74.4 years (mean 60.3), we calculated hemispheric BPI factors. For two subgroups of 10 patients chosen at random, several data-processing parameters, including the number of noise suppression steps and the linear slope interval for the Patlak fit, were assessed. To determine the influence of region of-interest selection and to estimate intra- and inter-observer differences, three independent observers conducted a repeat analysis of all 46 patients. From five patients who underwent the same injection procedure twice, an estimate of intra-subject reproducibility was calculated. Temporal noise reduction of the input data significantly decreased the intra-observer variability. Visual estimation of the linear interval in the Patlak curve is much less reproducible than automatic interval selection; very high interval borders in particular significantly decrease the calculated BPI. The intra-observer coefficients of variation for the BPI were 5.3, 5.6 and 7.9% respectively, corresponding to 2.8, 3.0 and 4.1% when converted to hemispheric CBF. The slight inter-observer differences found could be attributed to differing processing parameters. For the five patients in whom the procedure was repeated, the hemispheric BPI reproducibility index was on average 2.6%. Determination of absolute hemispheric blood flow can be performed in a precise manner by means of a dynamic scan during the first 2 min after tracer injection after careful optimization of the processing parameters. PMID- 9949412 TI - Assessment of chemotherapy-induced changes in bone sarcomas: clinical experience with 99Tcm-MDP three-phase dynamic bone scintigraphy. AB - The aim of this study was to evaluate the value of three-phase dynamic bone scintigraphy (TPBS) in the assessment of the response of bone sarcomas to pre operative chemotherapy and to correlate serial scintigraphic changes with histological findings. The study group comprised 27 patients (osteogenic sarcoma, n = 20; Ewing's sarcoma, n = 5; malignant fibrous histiocytoma, n = 2) with a mean age of 19.2 years. All patients received 99Tcm-methylene diphosphonate TPBS before and after pre-operative chemotherapy. Each phase of the imaging procedure was interpreted qualitatively and quantitatively. The percentage of tumour necrosis was analysed on resection materials following surgery. Histologically, 12 patients were non-responsive (tumour necrosis less than 90%) and 15 patients were responsive (tumour necrosis more than 90%). A decrease in the tumour blood flow ratio and extension were the most notable findings in the responders. The mean change in the tumour blood flow ratio following therapy was 58.7 +/- 8.3% and 19.9 +/- 26.6% (P < 0.005) in responders and non-responders respectively. The accuracy of three-phase imaging and static bone scintigraphy was 88% and 74% respectively. Since bone scintigraphy is a valuable technique owing to its ability to detect distant metastases in clinically early disease, TPBS should be helpful in monitoring therapy effects without any additional cost or radiation dose. PMID- 9949413 TI - The use of image registration in the analysis of bone scans for the assessment of temporomandibular joint uptake. AB - Bone scanning is a commonly used technique in the assessment of patients with facial asymmetry. Uptake in the temporomandibular joints can be assessed quantitatively, either as a right-to-left ratio or as the uptake in the joint relative to some other bony structure. We used image registration techniques in the development of an automatic method of quantitative analysis and compared this with a manual region of interest method. Both image warping and region warping were studied. Normal ranges were established in a series of 25 subjects with no evidence of temporomandibular disorder. The results of this study indicate that, by using image registration and standard regions of interest, the results from normal subjects show a smaller standard deviation and improved correlation between observers when compared with manual analysis. PMID- 9949414 TI - Effects of alternative reconstitution procedures on the labelling efficiency and in vitro stability of 99Tcm-labelled radiopharmaceuticals. AB - Adding normal saline (NS) separately before 99Tcm-sodium pertechnetate to MDP cold kits has been shown to reduce substantially the radiation dose to the hand. A similar dose reduction will probably prove to be valid with the preparation of most other 99Tcm-labelled radiopharmaceuticals. However, it is unknown how this altered reconstitution procedure may affect the labelling efficiency and in vitro stability of the 99Tcm-labelled radiopharmaceuticals. We have evaluated the effects on the labelling efficiency and in vitro stability of 99Tcm-labelled MDP, mertiatide and sestamibi reconstituted with three different methods: adding normal saline before 99Tcm activity (NS/Tc); adding 99Tcm activity before normal saline (Tc/NS); and the standard reconstitution method of adding both 99Tcm activity and normal saline together. The labelling efficiency and in vitro stability were evaluated by measuring the radiochemical purity of each radiopharmaceutical tested at 0, 1, 3, 6, 12 (except 99Tcm-MDP) and 24 h after reconstitution. For 99Tc-mertiatide, there was a very slight difference in the labelling efficiency, mostly due to the Tc/NS method being approximately 0.29% lower across time post-reconstitution than the standard method. For 99Tcm labelled MDP and sestamibi, there were no differences between the three methods in terms of labelling efficiency and in vitro stability. In conclusion, both alternative methods (i.e. NS/Tc and Tc/NS) appear not to have any detrimental effect on the labelling efficiency and in vitro stability of the 99Tcm-labelled radiopharmaceuticals that we tested. However, of the two alternative kit reconstitution methods, we recommend the NS/Tc method, since it may reduce the hand radiation dose. PMID- 9949415 TI - In vivo stability and metabolism of 99Tcm-labelled anti-CD4 monoclonal antibodies and Fab' fragments. AB - In a comparative study, the in vivo metabolic profile of 99Tcm-anti-CD4 monoclonal antibodies (MAb) and Fab' fragments (direct thiol-reduction method) was investigated in rats with adjuvant arthritis. Plasma samples were obtained 1, 4 and 15 h following intravenous injection and urine was collected over 15 h. The composition of the radiolabelled molecules was analysed by gel filtration chromatography. The profile of the complete MAb was as follows. (1) Serum: a predominant peak of 150 kDa (complete MAb; approximately 80%); three minor peaks of 125, 100 and 50 kDa (presumably H2L1, H2 and H1 chains; 14%); and two small peaks of approximately 1500 and 300 Da (presumably 99Tcm-glutathione and Cys 99Tcm-Cys; 5%). (2) Urine: minor peaks of 125, 100 and 50 kDa (15%), major peaks of 1500 and 300 Da (50%), and an additional 25-kDa peak (30%). The profile of the Fab' was as follows. (1) Serum: three minor peaks of 150 kDa [conceivably F(ab')2 plus soluble-CD4], 110 kDa [F(ab')2] and 95 kDa (Fab' plus soluble-CD4; together 30%); a predominant peak of 55 kDa (Fab'; 61%); and two minor peaks of 1500 and 300 Da (8%). (2) Urine: predominantly a 55 kDa (16%) and 1500 and 300 Da peaks (74%). Also, the anti-CD4 Fab' showed higher urine excretion and lower plasma levels than the complete anti-CD4 MAb, but still more favourable tissue-to-blood ratios following scintigraphy of the arthritic joints. Thus, the complex metabolic profile of the anti-CD4 Fab' does not appear to interfere with specific targeting of the inflamed synovial membrane. PMID- 9949416 TI - Effects of the method of drawing regions of interest on the differential diagnosis of extrapyramidal syndromes using 123I-iodolisuride SPET. AB - Various parameters are currently used for the semi-quantitative assessment of dopamine D2 receptors and differ according to the delineation of the striatal region of interest (ROI) and the choice of the reference ROI. The aim of this study was to assess the value of different ROI approaches in differentiating patients with normal or increased numbers of D2 dopamine receptors (group 1 = Parkinson's disease, n = 8) from patients with decreased dopamine D2 receptors (group 2 = other extrapyramidal syndromes, n = 9) using 123I-iodolisuride SPET (ILIS-SPET). 123I-iodolisuride (190 +/- 31 MBq) and 99Tcm-ethyl cysteinate dimer (99Tcm-ECD) perfusion SPET were performed in the same position, with a dual headed gamera camera equipped with fan beam collimators. Both a geometric approach (ellipse, circle or rectangle) and an anatomical approach using the CT scan and perfusion SPET as anatomical guides were used to draw striatal and reference ROIs. A total of 33 different parameters were calculated for each patient, indicating the ratio of counts between the striatal and reference ROIs (frontal, occipital cortex or cerebellum) and the asymmetry between the right and left striatum. More significant differences between group 1 and group 2 were found by using geometric ROIs than by using anatomical ROIs. The most discriminant ratios were the caudate/occipital, caudate/frontal and striatum/occipital ratios (P = 0.001, P = 0.002, P = 0.003 respectively). A close correlation was found between the striatum/caudate and striatum/occipital ratios, but not between the striatum/frontal and striatum/occipital ratios or between the striatum/frontal and striatum/caudate ratios. We conclude that the occipital cortex is the best reference for the semi-quantitative evaluation of dopamine D2 receptors as the frontal cortex could include some dopamine D2 receptor-bound radioligand, and that the caudate/occipital ratio is an appropriate parameter for differentiating Parkinson's disease from non-Parkinson extrapyramidal syndrome by 123I-iodolisuride SPET. PMID- 9949417 TI - The use of delay tanks in the management of radioactive waste from thyroid therapy. AB - An underground system of tanks was installed to delay the discharge of 131I waste from the thyroid therapy unit to the on-site sewage treatment plant. As a consequence, the level of radioactivity discharged to sewage has fallen by a factor of 530, reducing the radiation dose to hospital and auxiliary service staff. Cancer patients are no longer required to collect their urine, hence increasing the hygiene for all concerned. A model was developed of iodine waste which estimates the dose rate above the delay tanks and the activity of iodine discharged. The maximum effective dose to a member of the public due to the holding tanks is 40 microSv.year-1. There is now better management of the radioactive waste from the iodine therapy ward. PMID- 9949418 TI - A 'one-stop' vascular clinic: initial experience of an out-patient immediate access radioisotope limb blood flow service. AB - The availability of an 'immediate-access' nuclear medicine service has facilitated the introduction of a 'one-stop' vascular clinic, enabling radioisotope limb blood flow and Doppler ankle:brachial index tests to be performed within 2 h of each other for new patient referrals. The test results are available to assist clinical management decisions during the same clinical session. A patient satisfaction survey was undertaken in 71 patients to assess their perspective of this service provision. Fifty-one (72%) patients returned the questionnaire. All respondents preferred to have attended the 'one-stop' clinic to having to return for investigations on a separate occasion. The patient satisfaction survey has identified patient perceived advantages of improved diagnostic efficiency, reduced number of visits, reduced patient worry and the minimization of patient travel costs. During the study period, 83% of allocated gamma-camera imaging slots were utilized, demonstrating that immediate-access nuclear medicine service provision linked to specific clinics can be a practicable solution to reducing waiting times for investigative tests. This is believed to be the first reported immediate-access nuclear medicine service, as opposed to the emergency investigations normally offered to clinically urgent requests. PMID- 9949419 TI - A way to reduce the radius of rotation in brain SPET with a single-head system. AB - To optimize spatial resolution in single photon emission tomography (SPET), it is essential to minimize the radius of rotation. In brain studies, different methods have been used to avoid shoulder interference when the radius of rotation is minimized: rectangular fields of view, modifications to the shielding around circular detectors and fan or cone beam collimators. However, few single-head systems can adopt these developments, particularly older cameras. A non-standard image acquisition method to reduce the radius of rotation in brain SPET with a single-head gamma camera is presented. The method applies a defined transformation to the original acquired images, maintaining the whole of the brain inside the field of view without shoulder interference and meeting the condition: pixel size < or = FWHM/3. With this method, it is possible to reduce the radius of rotation to 16 cm and to obtain a transaxial spatial resolution of 15.98 mm, which is 3.5 mm less than with the standard method used in our laboratory. This procedure was implemented for a Siemens Gammasonics ZLC 3700 gamma camera and has been validated in single-slice brain phantom studies. The method has the advantage of not requiring any complex or costly hardware. PMID- 9949420 TI - Radiopharmaceutical kit modification. PMID- 9949421 TI - Volumetric bone mineral density derived from dual-energy X-ray absorptiometry measurements. PMID- 9949422 TI - The 1998 Wendell Hughes Lecture. Evisceration: is sympathetic ophthalmia a concern in the new millennium? AB - PURPOSE: To investigate a possible relationship between evisceration and sympathetic ophthalmia. METHODS: Data from Mt. Sinai Medical Center and University Hospitals of Cleveland were collected and histopathologic specimens were reviewed for 51 of 90 patients who underwent evisceration between 1980 and 1996 and who returned for follow-up examinations. Additionally, a survey was sent to members of the American Society of Ophthalmic Plastic and Reconstructive Surgery, the Uveitis Society, and the Eastern Ophthalmic Pathology Society to determine the number of enucleations and eviscerations performed and the documented incidence of sympathetic ophthalmia after evisceration. RESULTS: No clinical or histopathologic evidence of sympathetic ophthalmia after evisceration was found among patients treated at the two medical centers. The collective surveys showed a strong preference for enucleation over evisceration, but did not document evidence of sympathetic ophthalmia after evisceration. CONCLUSIONS: Evisceration is an effective and safe procedure with a low risk for sympathetic ophthalmia. PMID- 9949424 TI - Use of mitomycin C in repeat dacryocystorhinostomy. AB - PURPOSE: The usefulness of a single intraoperative application of mitomycin C was investigated in repeat dacryocystorhinostomy for membranous failure. METHODS: Mitomycin C (0.3 mg/ml for 3 minutes) was topically applied to the fistula site in eight patients undergoing repeat dacryocystorhinostomy for membranous failure. RESULTS: All patients remain asymptomatic and anatomic patency confirmed by probe and irrigation with a mean follow-up period of 14.6 months (range, 6-26 months). No postoperative complications associated with the use of mitomycin C were observed. CONCLUSIONS: In patients who do not maintain a patent fistula after dacryocystorhinostomy because of membranous occlusion of the rhinostomy site, the adjunctive use of mitomycin C may increase the success rate of repeat dacryocystorhinostomy. PMID- 9949423 TI - Eyelid crease incision for lateral orbitotomy. AB - PURPOSE: The authors describe a surgical incision and technique for lateral orbitotomy that is intended to minimize visible scarring and deformity. METHODS: This is a noncomparative, interventional, retrospective case series. Other surgical approaches for lateral orbitotomy are briefly reviewed. The authors' technique includes incision placement within the natural upper eyelid crease, with minimal extension in a relaxed skin tension line; dissection to the superior and lateral orbital rims in the submuscular plane; and wide dissection within the subperiosteal space. Criteria are described for inclusion of a bone flap in the technique. RESULTS: The eyelid crease incision has been used for exposure of the superolateral diagonal half of the orbit in approximately 600 cases. A variety of pathologic conditions affecting the orbital bones or the subperiosteal, extraconal, or intraconal spaces have been treated. Surgical exposure has been adequate to achieve the goals of surgery in individual cases, and the cosmetic results have been preferable to those the authors achieved using other surgical incisions. CONCLUSIONS: The eyelid crease incision for lateral orbitotomy allows dissection in relatively avascular planes, involves minimal transection of orbicularis muscle and lymphatic channels, and results in negligible postoperative scarring. Depending on the size and location of the lesion and the goal of surgery, the eyelid crease incision may be used without a bone flap. However, when a bone flap is needed, the incision does not restrict its size. PMID- 9949425 TI - Positron emission tomography in patients with benign essential blepharospasm. AB - PURPOSE: To identify possible abnormalities in regional cerebral glucose metabolism in patients with benign essential blepharospasm or Meige syndrome using positron emission tomography. METHODS: Ten patients with benign essential blepharospasm and one patient with Meige syndrome were examined using positron emission tomography with deoxyglucose labeled with fluorine 18. The severity of muscle spasm at the time of positron emission tomography was recorded in each patient. In five patients, positron tomography was performed on two occasions (once before and again 1 to 2 weeks after botulinum injection) to look for reproducibility of the findings on positron emission tomography also to see if there was any correlation between the severity of symptoms and positron emission tomography findings. RESULTS: The mean reference ratio for fluorodeoxyglucose F18 metabolism was significantly elevated in the striatum compared with the frontal, temporal, or parietal regions. Glucose metabolism was also elevated in the thalami. There was no correlation between the severity of blepharospasm and the degree of hyperactivity in the striatum. In the patients who underwent positron emission tomography scanning on two occasions, there was no significant difference between the two studies in any of the regions analyzed. CONCLUSIONS: The authors' findings support the hypothesis that benign essential blepharospasm and Meige syndrome may be associated with overactivity of the striatum and the thalamus. Positron emission tomography may prove to be a useful research tool and a possible adjunct diagnostic technique for benign essential blepharospasm and Meige syndrome. PMID- 9949427 TI - Orbital development after enucleation in early childhood. AB - PURPOSE: To identify growth retardation in the orbits of children who have undergone enucleation and orbital implantation. METHODS: Children who underwent unilateral enucleation for retinoblastoma were examined. Any patient who had received external beam radiation or chemotherapy was excluded. Follow-up time was 5.5 to 10 years (mean, 8.33 years). Several linear measurements were made on the enucleated orbit and the fellow orbit. These measurements were compared using the paired Student t test and multivariate analysis of variance. RESULTS: There was no statistically significant difference in any of the measured orbital dimensions between the enucleated and fellow orbits. CONCLUSIONS: Enucleation in children, when combined with a large orbital implant, does not cause orbital growth retardation. PMID- 9949426 TI - Role of local amphotericin B therapy for sino-orbital fungal infections. AB - PURPOSE: Sino-orbital fungal infections are serious complications of diabetes and immunosuppression. Standard treatments include surgical debridement of the involved tissues with possible orbital exenteration, intravenous antifungal therapy, and improvement of the host's immunocompetence and metabolic state, when possible. The role of conservative orbital debridement combined with local amphotericin B irrigations in the treatment of these patients was evaluated. METHODS: The records of seven consecutive patients with sino-orbital fungal infections, who were treated with limited surgical debridement and local and systemic amphotericin B therapy, were reviewed. The underlying disorders of these patients included acute lymphoblastic leukemia, immunosuppression after renal transplantation, diabetes mellitus, and acquired immunodeficiency syndrome. The fungal species identified included Rhizopus, Mucor, and Aspergillus. RESULTS: Follow-up ranged from 4 months to 4 years. All patients retained their preoperative visual acuities. Only one patient ultimately underwent an orbital exenteration for progressive orbital fungal infection. The remaining patients had either complete or incomplete (without further progression) resolution of their fungal infection. Two of the seven patients died of unrelated causes, and no patient died of uncontrolled fungal spread. CONCLUSIONS: Conservative orbital debridement with local amphotericin B irrigations is an effective adjunct in the control of sino-orbital fungal infections, especially in patients with reversible immunosuppression and good preoperative visual acuities. PMID- 9949428 TI - Predicting the ideal implant size before enucleation. AB - PURPOSE: This study of volume replacement in anophthalmic sockets compares the volume replaced by the implant and prosthesis with the volume removed from the socket and evaluates A-scan ultrasonography as a tool to predict an ideal implant size before enucleation. METHODS: In this retrospective study of 59 anophthalmic patients, the volume replaced by the implant and the prosthesis was compared with the volume of the enucleated eye. The volume removed was estimated by calculating the volume of the fellow eye using A-scan ultrasonography. Enophthalmos and superior sulcus deformity were measured and correlated with the percent volume replacement in the anophthalmic sockets. RESULTS: Greater enophthalmos and superior sulcus deformity were found in patients with less than 100% volume replacement compared with those with 100% or more volume replacement. The axial length determined by A-scan ultrasonography of the fellow eye suggested that a larger implant size should have been placed in 76.3% of those patients with less than 100% volume replacement. Sixty-three percent of adult patients could have received an implant more than 22 mm in diameter to fill 80% of the volume removed at enucleation. CONCLUSIONS: A-scan ultrasonography of the fellow eye provides a useful tool for predicting the implant size before surgery for optimal volume replacement. PMID- 9949429 TI - Unusual orbital foreign bodies. AB - PURPOSE: To describe the clinical features of patients with unusual orbital foreign bodies. METHODS: The clinical histories, preoperative photographs, imaging studies, and surgical pathologic findings of five patients with unusual orbital foreign bodies are presented. Additionally, published reports pertaining to similar cases were reviewed. RESULTS: The five patients treated by the authors had good outcomes. CONCLUSIONS: An orbital foreign body may be overlooked because a small penetrating wound may be accompanied by minimal or no signs of inflammation early in the clinical course. A careful history and physical examination, imaging studies, and a strong suspicion are helpful for establishing the diagnosis of an orbital foreign body. PMID- 9949430 TI - Bilateral eyelid edema: an uncommon presentation of Rosai-Dorfman disease. AB - PURPOSE: Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) is a rare entity with ophthalmic manifestations in 11% of patients. Orbital and eyelid involvement as the presenting features is even more unusual. METHODS: The authors report the clinical findings of a 41-year-old man with Rosai-Dorfman disease presenting as eyelid edema. Biopsy of the involved tissue was analyzed by light microscopy. RESULTS: Histologically the orbicularis muscle contained a patchy infiltrate of lymphocytes, plasma cells, and large pale histiocytes. The histiocytes had lymphocytes within them, a condition referred to as lymphocytophagocytosis. CONCLUSIONS: Rosai-Dorfman disease is a rare clinical entity that may occasionally manifest with eyelid edema. Biopsy reveals a characteristic histopathologic picture. PMID- 9949431 TI - Porous polyethylene channel implants: a modified porous polyethylene sheet implant designed for repairs of large and complex orbital wall fractures. AB - PURPOSE: To evaluate the effectiveness of a modified porous polyethylene implant in orbital fracture repair. A porous polyethylene channel implant (PPCI) has internal channels that accept mini- or microplates from conventional plating systems, facilitating fixation to bone in the reconstruction of large, complex orbital fractures. METHODS: The authors used 29 PPCIs to repair 25 orbits. Seventeen cases involved repair of an acute (less than two weeks after injury) fracture of one or more orbital walls. Eight cases represented delayed reconstruction of orbital walls for late enophthalmos or for residual defects after previous operations. RESULTS: A PPCI provides a stable platform for orbital soft tissue. Excellent results were obtained in all patients with acute orbital fractures, whereas good or excellent corrections of enophthalmos and hypoglobus were achieved in all patients who underwent late repair. There were no instances of orbital infection, implant exposure or migration, worsening diplopia, visual loss, or loss of structural support during 31 months of follow-up. CONCLUSIONS: A PPCI allows controlled placement of a porous polyethylene sheet with secure fixation to stable bone. The implant design allows it to be cantilevered from the orbital rim to serve as a stable platform when fractures are too large to support the implant in the posterior orbit. PPCIs are ideally suited for reconstruction of defects resulting from displacement of orbital walls and for repair of posterior floor fractures, medial wall fractures, and combined floor and medial wall defects. PMID- 9949432 TI - Management of relative proptosis with a porous polyethylene orbital rim onlay implant. AB - PURPOSE: The position of the globe relative to the orbital rim plays a significant role in the relationship between the eyelids and the cornea. A prominent globe (relative proptosis) may cause eyelid retraction and exposure keratopathy. Simple horizontal lower eyelid tightening exacerbates eyelid retraction. Optimal correction with an orbital decompression or advancement of the orbital rim entails considerable risk. A technically simpler alternative, placement of an orbital rim onlay implant, was evaluated. METHODS: Fourteen patients with symptomatic relative proptosis underwent placement of a porous polyethylene orbital rim onlay implant. RESULTS: Lower eyelid position, exposure keratopathy, and ocular discomfort were improved in all patients. Two patients required minor surgical revisions. CONCLUSIONS: Porous polyethylene orbital rim onlay implants are a satisfactory option to treat the sequelae of relative proptosis. PMID- 9949433 TI - Recent advances in molecular and molecular cytogenetic techniques have enabled the diagnosis of some inherited diseases from a single cell. PMID- 9949434 TI - Clinical evaluation of preimplantation genetic diagnosis. PMID- 9949435 TI - Genetic concerns for the subfertile male in the era of ICSI. AB - The treatment of severe male factor infertility has seen remarkable advances in the last five years with the introduction and widespread use of intracytoplasmic sperm injection (ICSI). Although ICSI represents one of the most important advances in the treatment of the subfertile male, significant concerns exist regarding the potential for transmission of abnormal genes to the offspring because many of the natural barriers to conception have been bypassed. Because these couples were not able to conceive prior to ICSI, the long-term genetic consequences in these offspring are largely undefined at this time. Genetic abnormalities related to male infertility need to be considered in terms of being (1) causative for male infertility and (2) potentially transmissible to the offspring. Reasons for pursuing a genetic evaluation include (1) establishing a diagnosis, (2) establishing a possible genetic origin, (3) clarifying the pattern of inheritance, and (4) providing information on natural history, variation and expression. The three most common known genetic factors related to male infertility are cystic fibrosis gene mutations leading to congenital absence of the vas deferens, Y-chromosome microdeletions leading to spermatogenic impairment, and karyotype abnormalities. When congenital bilateral absence of the vas deferens with azoospermia is encountered, cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations are commonly the underlying cause. When testicular failure is manifest by azoospermia or severe oligoszoospermia, Y chromosome microdeletions may be present in approximately 10-15 per cent of otherwise normal appearing men. Karyotyping can uncover potentially transmissible genetic abnormalities in the infertile male including structural chromosomal disorders such as Klinefelter's (classic 47,XXY), mixed gonadal dysgenesis, chromosomal translocations and XYY syndromes. Finally, potential male infertility genes in animal models are reviewed. Without question, advances in clinical and basic research raise scientific and social issues that must be addressed. PMID- 9949436 TI - The expression of genes in human preimplantation embryos. AB - The study of gene expression in human preimplantation embryos is establishing itself as a necessary dimension of developmental biology and medical genetics. Transcripts identified in human preimplantation embryos include housekeeping genes, transcription and growth factor genes, sex-determining genes, tissue specific genes and novel genes, as well as genes of unknown function. Strategies are being developed which will eventually permit the most sophisticated gene expression studies on single human embryos of co-ordinated transcription and translational regulation. There is both a need for international co-operation for the systematic construction of expression maps and a need to establish databases of expression patterns during different stages of human development. Understanding how genes are regulated in humans is essential for understanding both normal development and disease. Until recently, studies of gene expression and regulation during embryogenesis were almost exclusively limited to prokaryotes and to eukaryotes other than man. The introduction of artificial reproductive technologies in conjunction with the development of recombinant molecular technologies applicable to single cells has made possible the study of human development at its earliest stages (Pergament and Bonnicksen, 1994). Although there are still enormous technical challenges, robust strategies have been, and continue to be, developed for connecting DNA sequence to such endophenotypes as timing and level of genes expression at the single cell level. Questions currently being asked in human developmental genetic studies concern the pronucleus, the zygote and the preimplantation embryo: what genes are expressed? When are they expressed? What functions do they perform and how, in sequence or in combination? And, what elements control and regulate their expression? This review provides an overview of current knowledge about the expression of different embryonic genes during early human development and discusses future prospects, which includes a need for international co-operation similar to the Human Genome Project. PMID- 9949437 TI - Results of a survey of the legal status and attitudes towards preimplantation genetic diagnosis conducted in 13 different countries. AB - Considerable differences in the regulatory oversight of preimplantation genetic diagnostic (PGD) services exist among countries, ranging from total bans on any embryo manipulation to the almost complete absence of any regulations or authority. A survey of centres offering PGD services revealed common concerns about the creation of embryos for research, altering the pattern of normal embryo development and the potential for misuse in the clinical application of PGD. PMID- 9949438 TI - Application of single-needle blastomere biopsy in human preimplantation genetic diagnosis. AB - We have tested and subsequently successfully applied a single-needle approach to obtain blastomere biopsies from human preimplantation embryos for preimplantation genetic diagnosis (PGD). The method was first evaluated in a mouse system and shown to be compatible with a high degree of in vitro and in vivo development of biopsied mouse embryos. Furthermore, we showed that biopsied mouse embryos after transfer to recipient mice underwent implantation, normal development and delivery. Litters were followed through puberty and adulthood and shown to be normal with regard to sexual function and also a panel of biochemical and morphological parameters including organ histology. Successful human preimplantation diagnosis, followed by pregnancies and birth of healthy babies, was established with two out of three couples carrying a risk to transmit chromosomal abnormalities leading to severe disease. This is the first report of the successful use of a single-needle approach in human PGD. Considering its simplicity, we conclude that the single-needle approach is an attractive alternative for biopsies in PGD. PMID- 9949439 TI - Strategies for preimplantation genetic diagnosis of single gene disorders by DNA amplification. AB - Preimplantation genetic diagnosis (PGD) is an alternative to prenatal diagnosis for ensuring the genetic health of offspring born to families affected by inherited disease. This paper sets out to review current protocols for the diagnosis of single gene defects in human preimplantation embryos. These methods, which depend on DNA amplification using PCR, are subject to a variety of pitfalls, such as allele dropout (ADO), contamination and reduced amplification efficiency. Advances in single cell DNA amplification, such as improved multiplex PCR protocols, fluorescent-PCR and whole genome amplification (WGA), can be applied to address some of these problems. Different PGD strategies are discussed in the context of their clinical application. PMID- 9949440 TI - Assessment of the reliability of single blastomere analysis for preimplantation diagnosis of the delta F508 deletion causing cystic fibrosis in clinical practice. AB - Following the birth of a baby girl confirmed to be homozygous normal for the delta F508 deletion causing cystic fibrosis (CF), many single-gene defects have been diagnosed by polymerase chain reaction (PCR) for preimplantation genetic diagnosis (PGD). A few misdiagnoses have been reported but no large-scale studies have been performed to assess the accuracy of diagnosis in a clinical setting. Here we focus on a series of 15 delta F508 PGD cycles performed at the Hammersmith hospital in an 18 month period. All the spare embryos that had not been selected for transfer after clinical diagnosis were disaggregated and the blastomeres were analysed individually to confirm the clinical results and assess the reliability of single blastomere analysis by the nested PCR method. A total of 484 blastomeres from 112 embryos of different delta F508 genotypes were analysed. The amplification rate for nucleated blastomeres was 95 per cent and the overall accuracy of diagnosis was 89 per cent. Using these figures, we calculate that the chance of selecting an affected embryo instead of a homozygous unaffected or heterozygous carrier is 1.3 per cent, and 0.3 per cent of selecting an affected embryo as unaffected when heterozygotes were not considered for transfer. Misdiagnoses risks were negligible when embryos were considered for transfer after obtaining two concordant results from the same embryo. This study highlights the fact that heterozygous carrier embryos are more often associated with misdiagnoses, due to the failure of amplification of one of the two alleles in heterozygous cells (allele dropout (ADO)) and undetected contamination. In a recessive condition such as CF, ADO cannot result in a serious error. Misdiagnoses due to contamination are potentially more dangerous, they, however, can be limited by only selecting homozygous unaffected embryos for transfer as the risks are quadrupled when heterozygotes are also considered for transfer. For diagnoses of dominant conditions we strongly recommend the systematic analysis of two blastomeres per embryo and the transfer of only embryos with two independent concordant results. PMID- 9949441 TI - Multiple genetic diagnoses from single cells using multiplex PCR: reliability and allele dropout. AB - We used a multiplex fluorescent PCR system containing seven primer sets on single cells from three different cell types (buccal, corneal and blastomere cells) and more than 3500 heterozygous alleles to investigate reliability and extent of allele dropout in multiplex PCRs at the single cell level. All three cell types gave similarly high reliability, accuracy and allele dropout rates, with similar reliability between singleplex and multiplex PCRs. Allele dropout was also consistent between the three cell types and did not significantly increase as allele size increased. These results indicate that multiplex fluorescent PCR is a reliable and accurate method of obtaining multiple diagnosis (eight chromosomes simultaneously) from single cells and maximizes the information available from single cell analysis. PMID- 9949442 TI - Non-disclosure preimplantation genetic diagnosis for Huntington's disease: practical and ethical dilemmas. AB - Prenatal diagnosis of Huntington's Disease (HD) is controversial. Selective abortion is considered unacceptable by some, since, being a late-onset disorder, any child born carrying the HD mutation might still expect many years of disease free life. The test result itself has implications for the parents and other members of the family who may have decided not to be tested but who know that they may be at risk because a family member is affected. For this reason some potential carriers do not want to know their carrier status and may prefer prenatal exclusion testing. However, since half the fetuses carrying the affected grandparental allele may be normal, aborting these fetuses is also controversial. Preimplantation genetic diagnosis (PGD) has been suggested as an alternative by which asymptomatic individuals who are at high risk of carrying HD can avail themselves of antenatal genetic testing without incurring the emotional, social and financial burdens that might result from the presymptomatic disclosure of their own carrier status. However, non-disclosure testing of embryos in vitro presents specific practical difficulties. Assurance of absolute secrecy is difficult in the large team required for in vitro fertilization biopsy and diagnosis, and changes in practice which may be required to maintain the deception may be unethical. PMID- 9949443 TI - Preimplantation diagnosis for Huntington's disease (HD): clinical application and analysis of the HD expansion in affected embryos. AB - Huntington's disease (HD) is an autosomal dominant disease characterized by motor disturbance, cognitive loss and psychiatric manifestations, starting between the fourth and the fifth decade, followed by death within 10-20 years of onset of the disease. The disease-causing mutation is an expansion of a CAG triplet repeat at the 5' coding end of the Huntington gene. We have developed a single-cell PCR assay for the HD gene in order to propose preimplantation genetic diagnosis (PGD) for the couples at risk. We present here our first results with our first nine PGD cycles and also discuss the behaviour of the disease-causing expansion in pre implantation embryos. PMID- 9949444 TI - Chromosome translocations: segregation modes and strategies for preimplantation genetic diagnosis. AB - Preimplantation genetic diagnosis (PGD) offers polymerase chain reaction tests for an increasing range of single gene defects, and fluorescence in situ hybridization tests for sex determination (for X-linked conditions) and for aneuploidy detection. Patients carrying chromosome translocations with a high reproductive risk are increasingly seeking to increase their chances of a normal pregnancy with the help of PGD, for which they present a special challenge. This paper describes the behaviour of reciprocal translocations at meiosis, discusses current methods of detecting meiotic outcomes at the preimplantation stage and outlines ways forward for preimplantation diagnosis of these common rearrangements. We also propose a more general strategy using recently developed chromosome-specific sub-telomeric probes, combined, if possible, with proximal probes, to form a strong diagnostic tool. PMID- 9949445 TI - Case report: chromatid exchange and predivision of chromatids as other sources of abnormal oocytes detected by preimplantation genetic diagnosis of translocations. AB - Preimplantation genetic diagnosis of translocations can be performed on first polar bodies (PB) at metaphase stage using FISH with whole-chromosome painting DNA probes. Here we report the use of this method in a couple in which the female was a carrier of a balanced translocation 46,XX,t(11;16)(q21;q22). This case unusual in that two polar bodies showed recombination events between the homologue chromosomes of 11 and 16 pairs, resulting in M-II oocytes with monovalent chromosomes having a normal and a derivative chromatid. For this type of case, PGD analysis on polar bodies cannot give a useful result, because, at the second meiotic division, either of these chromatids could remain in the oocyte, resulting in a normal, balanced or unbalanced embryo. PGD analysis on blastomeres can provide a solution. 11 previous cases of PGD of translocations performed by metaphase PB analysis are reviewed. PMID- 9949446 TI - Preimplantation diagnosis of the aneuploidies most commonly found in spontaneous abortions and live births: XY, 13, 14, 15, 16, 18, 21, 22. AB - The present preimplantation diagnosis test is able to screen for the most common aneuploidies from single blastomeres in about five hours with a 15 per cent misdiagnosis. This means that the risk of spontaneous abortion and trisomic offspring for women of advanced maternal age could be reduced to the same level as younger women for whom prenatal diagnosis is usually not necessary. Better probes and more fluorochromes could improve the success rate of the test. PMID- 9949447 TI - [Secondary immune deficiency]. PMID- 9949448 TI - [Extrahepatic manifestations of chronic hepatitis C]. AB - AIM: To study incidence, special features and mechanisms underlying onset of extrahepatic lesions in HCV-infection. MATERIALS AND METHODS: Extrahepatic symptoms of chronic hepatitis C and its outcome--hepatic cirrhosis were studied in 157 patients. HCV-infection was confirmed by ELISA II and polymerase chain reaction (detection in the serum of anti-HCV and HCVRNA, respectively). Morphological studies of the liver were made in 134 patients, of other organs and tissues--in 20 patients. Immunological tests were made in 124 patients. Thyroid hormones, antibodies to thyroglobuline were measured with radioimmunoassay in 74 patients. RESULTS: Extrahepatic manifestations were found in 70(44.6%) patients with chronic hepatitis C (more frequently in hepatic cirrhosis), for the most part in women and in long-lasting disease. 54(43.5%) women had cryoglobulinemia, 27 of them showed it clinically. Patients with cryoglobulinemia and free of it exhibited varying frequency cutaneous vasculitis, Raynaud's syndrome, affection of the muscles and joints, nodular periartheritis, lesions of the lungs, myocarditis, autoimmune thyroiditis, Sjogren's syndrome, lichen ruber planus, porphyria cutanea tarda, immune cytopenia, autoimmune hemolytic anemia, hypoplastic anemia, monoclonal immunoglobulinopathy, B-cell lymphoma. Of high frequency were activity of rheumatic factor (66.9%), hypocomplementemia (31.8%), antinuclear antibodies (9.8%) and other immunological disorders. CONCLUSION: Some extrahepatic lesions in HCV-infection are detailed: frequent mixed cryoglobulinemia and associated vasculitides of different sites, malignant lymphoproliferative diseases, more frequent than in HBV-infection involvement of the thyroid and salivary glands, some skin lesions. PMID- 9949449 TI - [Epidemiological and clinical features of viral hepatitis in convicts of penitentiaries]. AB - AIM: Investigation of epidemiological and clinical features of viral hepatitides (VH) in convicts treated in clinics of penitentiaries. MATERIALS AND METHODS: VH were studied in 352 patients of the infection department of the special hospital in one of the penitentiaries of Russian Federation. 97 VH patients were followed up. Incidence of VH was also considered in 144 patients of the somatic department. Mean age of the patients was 24 years, mean duration of the last stay in the penitentiary 19 months. Forms of VH were diagnosed clinically, using EIA, ultrasound, laboratory tests. RESULTS: Serological markers HC-, HB-, HA- of viral infections were detected in 34.3, 32.3 and 11.4% of patients, respectively. VH of mixed etiology was found in 17.6% of cases. 52.1% of patients had previously injected narcotic drugs, 60.4% of them had concomitant infectious or parasitic diseases. 22.9% of the patients had serum proteins below 65 g/l. CONCLUSION: Convicts in the penitentiaries were infected primarily with hepatitis C, many of them had mixed infections and chronic hepatitis. More than half of them had associated infections infectious and/or parasitic diseases. At least one-fifth of the patients suffered from protein insufficiency. The causative agents can be transmitted through different routes, two or more at a time, iatrogenically among them. VH in convicts display special clinical features which allow to consider them as an independent syndrome. PMID- 9949450 TI - [Characteristics of viral hepatitis in addicts with consideration of lymphocyte membrane condition]. AB - AIM: To study changes in the condition of lymphocyte membranes of patients with acute viral hepatitis B (AVHB) in narcotic addicts. MATERIALS AND METHODS: 136 patients with AVHB have been examined for endogenic intoxication (plasma levels of middle-size molecular peptides, urine levels of red cells). 74% of the examinees had practiced parenteral injections of opium substitutes. Measurements were made of lymphocyte levels of malonic dialdehyde and superoxide dismutase activity characterizing free radical lipid peroxidation, enzymes of the main metabolic cycles. RESULTS: AVHB addicts often display antibodies to hepatitis C virus, high indices of endogenic intoxication. CONCLUSION: Viral hepatitis was associated with enhanced intensity of lymphocyte membrane lipid peroxidation correlating with the disease severity and duration irrespective of concomitant drug addiction. Early convalescence in drug addicts ran with persisting metabolic disturbances in the immunocompetent cells. This is a pathogenetic sign of the disease transformation to the chronic form. PMID- 9949451 TI - [Treatment of sever polyneuropathy caused by hepatitis B virus with interferon alpha]. PMID- 9949452 TI - [Plasma middle mass molecules in viral hepatitis]. AB - AIM: The study of the level of middle mass molecules (MMM) in blood plasma of patients in different periods of viral hepatitis; their relation to some routine markers of viral hepatitides; appropriateness of MMM test in differential diagnosis with other jaundices. MATERIALS AND METHODS: Plasma MMM content was measured in 123 patients aged 17-65. 28 of them had mild form of viral hepatitis, 56 had moderately severe and severe hepatitis, 39 had jaundice of other etiology. Healthy donors with MMM levels 1.18 +/- 0.02 optic units served as control. Computer correlation analysis discovered a rise in blood levels of MMM in the phase of jaundice development, a fall in the phase of the disease peak, rise again in the phase of jaundice attenuation and normalization in convalescents. The changes were small in mild disease, great in moderate and grave disease. In the absence of intoxication MMM made up 1.27 +/- 0.0.02 OU, in dramatic intoxication MMM level rose to 1.47 +/- 0.04 OU (p < 0.05). Correlation was not noted between MMM content and conventional markers of viral hepatitides. There was no rise in concentration of MMM in non-viral jaundice. CONCLUSION: MMM concentrations in plasma in viral hepatitides can be used as a prognostic and differential-diagnostic sign. PMID- 9949453 TI - [Isoenzymes of transferases in serum from diphtheria patients]. AB - AIM: Investigation of serum spectrum of isoenzymes AlAT, AsAT, GGT in diphtheria in adults. MATERIALS AND METHODS: The serum spectrum of cytoplasmic and mitochondrial isoenzymes AlAT, AsAT, GGT were studied in 12 bacterium carriers and 65 patients with diphtheria. Quite original evidence has been obtained on mechanism of hyperenzymemia. RESULTS: Diphtheria is associated with enhanced activity of cytoplasmic isoenzymes in correlation with intoxication severity. Spectrum of isoenzymes AlAT and especially GGT shifted to the side of mitochondrial fractions. There were no statistically significant differences in the activity and spectrum of isoenzymes in myocarditis and in its absence. In clinical recovery the spectrum of isoenzyme activity remained changed. CONCLUSION: It is suggested that dysisoenzymemia is related to active role of hepatocytes in utilization of diphtheria toxin, that carriers are not healthy people as hyperenzymemia is associated with morphological changes in the myocardium. PMID- 9949454 TI - [First case in Russia of coinfection of visceral leishmaniasis and HIV infection]. PMID- 9949455 TI - [Systemic affections in cytomegaloviral infection (cytomegaloviral disease) (case report)]. PMID- 9949456 TI - [Interferons and inductors of their synthesis (review)]. PMID- 9949457 TI - [Immune mechanisms in pathogenesis of hemorrhagic fever with renal syndrome (review)]. PMID- 9949458 TI - [Clinical and laboratory characteristics of cryptosporidiosis in Turkmenistan]. AB - AIM: The study of clinical symptoms of gastrointestinal lesions in subjects invaded with cryptosporidia. MATERIALS AND METHODS: From 1994 to 1997 383 patients with monocryptosporidiasis were observed. 75.7% of them were children. Cryptosporidia oocysts were identified in fecalia using Fulleborn technique. The specimens were stained according to Cill-Nilsson. RESULTS: Clinically, the invasion was characterized by acute onset, severe course in children, involvement of the whole gastrointestinal and respiratory tracts. CONCLUSION: Monocryptosporidiasis runs in Turkmenistan a more severe course compared to countries with moderately hot climate. PMID- 9949459 TI - [Clinico-epidemiological analysis of imported malaria in Donetsk region (1979 1997)]. AB - AIM: The study of possibility of reappearance of malaria foci in the Donets region. MATERIALS AND METHODS: 322 cases of imported malaria (IM) in the Donets region registered in 1979-1997 have been analysed clinically and epidemiologically. Malaria was diagnosed in immigrants from and visitors to Africa, Asia and Latin America, malaria-endemic Azerbaidjan, Tadzhikistan, Afghanistan. RESULTS: Late diagnosis of malaria occurred in immigrants and businessmen who got infected during their business trips. Causative agents of malaria imported from Azerbaijan and Asia were resistant to chemoprophylaxis with delagil and primaxine. Clinical forms of IM are described. CONCLUSION: There is a real danger of malaria reappearance in the Donetsk region as the residents are at risk of being infected from late-diagnosis foreign tourists, immigrants, refugees. PMID- 9949460 TI - [Terminology of systemic vasculitis (lecture)]. PMID- 9949461 TI - [Clinical problems of nonspecific aortic arteritis]. AB - AIM: The insight into the causes of late diagnosis and analysis of clinical variants of nonspecific aortic arteritis (NSAA) including rare forms--with involvement of the kidneys, intestine, lungs, heart. MATERIALS AND METHODS: Physical, laboratory and immunological tests, angiography, ultrasound dopplerography were employed in examination of 65 NSAA patients observed in 1955 1996. RESULTS: Accurate diagnosis of NSAA is made late (5 years from the first symptoms, on the average) when ischemic damage has become irreversible. The causes of such situation are outlined with special emphasis on NSAA variants running with affection of the lesser circulation vessels, coronary flow, kidneys (nephritis, amyloidosis), intestine (Crohn's disease, nonspecific ulcerative colitis). Men suffer more than women: they develop more frequently myocardial infarctions, thromboembolism. However, their arteries look better. Mechanisms of NSAA onset and progression may be related to defects in vascular endothelium, hyperproduction of antibodies to cardiolipin, antiendothelial antibodies. CONCLUSION: Management of NSAA meets with the problem of late diagnosis which means greater risk of severe vascular complications and deterioration of the prognosis. PMID- 9949463 TI - [Vasculitis and vasculopathies: common signs and special features (lecture)]. PMID- 9949462 TI - [Treatment of patients with systemic vasculitis (review)]. PMID- 9949464 TI - [Role of cryoglobulinemia in rheumatic diseases as illustrated by citizens of Moscow (resident population) and Tynda (migrants to Siberia)]. AB - AIM: To determine occurrence of cryoglobulinemia (CGE) in residents of Moscow with various rheumatic diseases and healthy subjects, in Tynda population (migrants to Siberia) with rheumatic arthritis (RA) and healthy ones. MATERIALS AND METHODS: CG screening was performed according to the WHO recommendations among 243 rheumatic patients from Moscow, 500 healthy subjects living in Moscow, 72 RA patients from Siberia and 1750 healthy Siberia migrants. RESULTS: CGE occurred more frequently among Moscovites with SLE and RA (28 and 19%, respectively). In RA Siberians CGE was present in 52%. In healthy Siberians CGE occurred in 8.4% of the examinees, in Moscovites it was extremely rare. In all the examinees CGE was associated with cryoglobulinemia syndrome. SLE and RA Moscovites had mixed CGE with monoclonal components (type II), RA Siberial migrants had CGE type II and III (mixed polyclonal). CONCLUSION: The study of CGE incidence in healthy migrants to Siberia with different duration of residence, measurements of metal ions in RA Siberians with and without CGE in the serum, blood cells and cryoprecipitates provided the authors with information for a new hypothesis of CGE origin and design of new policy of treating CGE. PMID- 9949465 TI - [Can local therapy of joint syndrome with Dolgit cream be used as an alternative to systemic nonsteroid antiinflammatory drugs in rheumatic diseases?]. AB - AIM: The trial of therapeutic effect of local therapy with dolgit cream of the joint syndrome in rheumatoid arthritis (RA), osteoarthrosis (OA) and juvenile chronic arthritis (JCA). MATERIALS AND METHODS: Cream dolgit was used locally with assessment of its effect by pains at rest, movement, palpation, swelling in 169, 98 and 102 patients with RA, OA and JCA, respectively. RESULTS: Subjective improvement was recorded in 75.6% of RA and 90% of OA patients, objective--in 80.9 and 87.2%, respectively. The cream enables a 30-50% reduction in daily dose of nonsteroid antiinflammatory drugs in 1/3 and 1/4 OA and RA patients, respectively. In JCA patients dolgit relieved symptoms of local inflammation. The response was growing in combination of dolgit with dimexide or magnetotherapy. Some of the OA patients experienced local skin itch which was not registered in children. No other side effects arose. CONCLUSION: Cream dolgit is effective in the treatment of joint syndrome in rheumatic patients, is well tolerated and may replace systemic nonsteroid antiinflammatory drugs in some patients. PMID- 9949467 TI - [Osteoporosis in elderly patients suffering form rheumatoid arthritis]. PMID- 9949466 TI - [Combined therapy of thrombocytopenia in SLE patient with antiphospholipid syndrome]. PMID- 9949468 TI - [Clinico-biochemical effectiveness of emoxpine in patients with bacterial bronchial asthma]. AB - AIM: To determine effectiveness of a synthetic antioxidant drug emoxipine in combined treatment of bacterial bronchial asthma (BBA). MATERIALS AND METHODS: A total of 59 BBA patients were treated who had the disease for 1-14 years. The previous treatment consisted of bronchodilating, mucolytic and expectorant drugs. 19 of them received i.m. adjuvant emoxipine for 10 days in daily dose 0.3 mg/kg as a 1% aqueous solution. Metabolic activity of alveolar macrophages (AM) was measured. RESULTS: Emoxipine-treated patients had reduced content of primary lipid peroxidation products and schiff bases in AM, catalase level in them returned to normal, blood levels of alpha-tocopherol went up. CONCLUSION: Emoxipine is beneficial for AM antioxidant defence system in BBA patients. PMID- 9949469 TI - [Pathogenetic aspects of hemolysis and changes of blood rheology in hereditary hemochromatosis]. AB - AIM: To establish changes of and correlations between erythrodieresis and blood rheology in hereditary hemochromatosis (HHC). MATERIALS AND METHODS: Hemorheologic indices (asymptomatic blood and plasma viscosity, that of blood at low shift speed, red cell deformity and aggregation) were studied in 42 HHC patients and 23 healthy donors. The patients were divided into groups by homozygous (groups 1 and 2) or heterozygous (groups 3 and 4) allel genes and sex (females-groups 2 and 4, males-groups 1 and 3). RESULTS: All the patients had increased resistance of red cells in high percentage of their high-resistance populations (correlation index 0.8-0.9) due to destruction and elimination from the circulation. These changes were more pronounced in males, similar in homo- and heterozygotes. The presence in the peripheral blood of red cells with high resistance is associated with a 25-30% decrease in the red cell rigidity, in groups 1 and 3 this decrease reached 30-40%. To a certain degree high deformity and aggregation of red cells is explained by high plasma viscosity (correlation index 0.4). Plasma viscosity was high in all the patients of all groups. CONCLUSION: HHC runs with rejuvenascence of erythroid cells. Changed activity of erythrodieresis and damage to red cells at the level of microcirculation may be involved in iron metabolism disturbance and development of tissue hemosiderosis. PMID- 9949470 TI - [Chronic adrenal insufficiency in female with myeloblastic leukemia]. PMID- 9949471 TI - [Clexane in prevention of acute venous thrombosis and pulmonary thromboembolism]. PMID- 9949472 TI - [Cardiovascular disorders in chronic renal failure]. PMID- 9949473 TI - [Current views on pheochromocytoma]. PMID- 9949475 TI - Experimental Rhazya stricta toxicosis in rats. AB - Saudi Rhazya stricta is used in folkloric medicine for the treatment of various disorders. R stricta leaves were fed to male Wistar albino rats at 2%, 10% or 50% of the diet for 6 w. Decreased growth rate, soft feces, dullness, ruffled hair and hepatonephrotoxicity were observed in rats on 10% and 50% Rhazya diet. Fifty percent Rhazya was fatal to rats, and hepatorenal lesions at 3 and 6 w confirmed changes in serum enzyme activity and in total protein, albumin, bilirubin and urea concentrations. Serum copper was decreased and zinc was increased in rats on 50% R stricta at 3 and 6 w, and were accompanied by anemia and neutropenia. Two percent Rhazya diet promoted growth as the plant leaves contained 28.3% crude protein and 16.6% crude fat and were not deficient in copper, zinc or iron. PMID- 9949474 TI - Toxic effects to mink of moniliformin extracted from Fusarium fujikuroi culture material. AB - Acute and subacute effects of i.p. exposure to moniliformin in mink (Mustela vison) were investigated. Moniliformin was extracted from Fusarium fujikuroi culture material containing 9,174 ppm moniliformin. An acute LD50 between 2.2 and 2.8 mg moniliformin/kg bw was determined for 9-mo-old female mink. Subacute exposure to 1.5 to 3.2 mg total moniliformin/kg bw resulted in dilated (right side) hearts rounded in appearance. Statistical differences observed in serum chloride and albumin, amylase activities, spun packed-cell volumes, red blood cell counts, hemoglobin concentrations, and hematocrit values between control and moniliformin-dosed mink were considered biologically insignificant because values were within ranges reported for normal mink. Electron microscopic examination of the right ventricular free heart wall of mink receiving acute or subacute doses of moniliformin revealed ultrastructural damage to myofibers, mitochondria, nuclei, Z- and M-lines and sarcoplasmic reticula, and increased extracellular collagen deposition. These results showed that mink are among the more sensitive mammals to moniliformin and that this mycotoxin specifically targets and damages the hearts of mink. PMID- 9949476 TI - Fructose-1,6-diphosphate in the treatment of oleander toxicity in dogs. AB - Oleander, a flowering plant that grows in the Mediterranean and southern US, contains the cardiac glycosides oleandrin, digitoxigenin and nerium, which inhibit Na(+)-K+ ATPase. Clinical manifestations of oleander toxicity include gastrointestinal irritation, marked hyperkalemia, A-V block, ventricular dysrhythmia, and not uncommonly death. Because fructose-1,6-diphosphate (FDP) has been shown to attenuate digoxin toxicity, we determined whether this agent would be effective in the treatment of the toxicity of these similarly-structured cardiac glycosides. Anesthetized dogs (n = 12) were infused i.v. for 5 min with 40 mg oleander extract/kg and then 6 dogs randomly selected from that group received a 50 mg/kg bolus of 10% FDP followed by a constant infusion. The other control animals received the same dosage of 10% dextrose. Within 5 min after oleander administration, all dogs developed dysrhythmias. The FDP-treated animals reverted to sinus rhythm within 1.58 +/- 0.15 h; none in the control group returned to sinus rhythm. One control dog died at 3 h from ventricular fibrillation. Marked hyperkalemia was observed in the control group; plasma K+ remained unchanged in the FDP group. Throughout the 4 h experimental period the FDP group maintained normal arterial pressures; in the control dextrose group, pressures were profoundly depressed. Cardiac output declined in both groups but remained higher in the FDP group. To determine the mechanism whereby FDP attenuates oleander toxicity, we studied the in vitro effect of FDP on oleander poisoned myocardial sarcolemmal membranes. At concentrations of 1 and 2 mg oleander inhibited Na(+)-K+ ATPase activity and addition of 500 microM FDP restored myocardial sarcolemmal Na(+)-K+ ATPase function. FDP effectively prevented hyperkalemia, reversed dysrhythmias and improved hemodynamics in vivo in this canine model of oleander toxicity and also restored sarcolemmal Na(+)-K+ ATPase activity in vitro. PMID- 9949477 TI - Adsorption effects of activated charcoal on metaldehyde toxicity in rats. AB - Metaldehyde has been widely used as a main ingredient of solid fuel for making fire and slug baits in Japan. It is also marketed as a color flame tablet for party goods (ENGELFIRE). Consequently, children have been poisoned by eating such tablets which they mistook for candy. As a result, poison information center calls are increasing. According to POISINDEX, the treatment for metaldehyde poisoning consists in prevention of adsorption by activated charcoal, seizure control and airway protection. However, the optimum dose of charcoal is not established. We studied the quantitative adsorption capacity of activated charcoal for acute oral toxicity of metaldehyde in rats. In vivo toxicity and absorption tests for metaldehyde in Wister rats were done. The detoxifying effect of activated charcoal on metaldehyde toxicity and inhibition of metaldehyde absorption were investigated. Ratios used of po activated charcoal given 30 min after dosing to 400 mg metaldehyde/kg po were 5:1, 2:1, 1:1, 0.5:1. Serum metaldehyde was determined by gas chromatography in the control group (no charcoal) and the various experimental groups. Metaldehyde mortality was completely prevented at the ratio of 5:1. Gastrointestinal absorption of metaldehyde was reduced significantly by 45.3% in comparison to the control rats. There was no acetaldehyde detected in the serum of the metaldehyde-dosed rats. Metaldehyde poisoning may be prevented by early po administration of activated charcoal in a ratio of > 5:1 compared to metaldehyde. The theory that acetaldehyde is the primary toxic agent in metaldehyde poisoning should be re evaluated. PMID- 9949478 TI - Fifteen cases of atropine poisoning after honey ingestion. AB - Fifteen persons developed atropine poisoning following consumption of wasp honey. Clinical signs, antidotal response and the presence of Datura plants near the wasp nests supported that the intoxications were caused by ingestion of atropine contaminated honey. Two deaths occurred from heatstroke because of the poisoning and high environment temperatures and intensive physical activity. PMID- 9949479 TI - Non-fatal clozapine (LEPONEX) intoxication with toxicokinetic evaluation. AB - A 29-y-old male attempted suicide with 3000 mg clozapine, 150 mg zopiclone, alprazolam and unknown quantities of alcohol. He was admitted in a deep hypotonic coma with respiratory depression, inhalation pneumonia and vascular collapse. Symptomatic treatment involved mechanical ventilation, vascular filling and antibiotics. The patient was discharged from the Intensive Care Unit 72 h after the suicide attempt with no sequelae. To detect and quantify clozapine in plasma, high-pressure liquid chromatography showed a 4 h absorption phase and a peak serum concentration of 5200 ng/ml. Three successive elimination t1/2 values of 38, 24 and 13 h were calculated. PMID- 9949480 TI - Forensic analysis of acute fatal poisonings in the southern districts of Trinidad. AB - A prospective autopsy study was undertaken at General Hospital in San Fernando, Trinidad, to analyze deaths that occurred from poisoning during 1996 and 1997. During that period 105 deaths occurred from acute poisoning. The major poisons used were: paraquat (80 cases), organophosphate/carbamate insecticides (10 cases), and anti-psychotic drugs (6 cases). Much less frequently, battery acid, ETHREL[Ethephon; (2-chloroethyl)phosphonic acid], phenols, ethanol, kerosene and flavine were the agents of choice. Suicide accounted for 99 (94.29%) deaths. Of these, 44.44% occurred in the 10-29 y-age-group. Ingestion of paraquat seems almost always fatal, since the large volumes ingested make treatment universally ineffective. Aspiration pneumonitis (100% of cases), and pneumothorax with pneumomediastinum (18.75% of cases), were remarkable autopsy findings in those dying from paraquat poisoning, while asphyxia due to respiratory paralysis was the mode of death from pesticide ingestion. Efforts to prevent suicide by poisoning may be more useful than treatment protocols. PMID- 9949481 TI - Intoxication in cattle from Cestrum diurnum. AB - Twenty-six Holstein calves with clinical and pathological effects suggesting a toxic plant intoxication were studied. A view of the plants in the region and blood examination (hemogram, albumin, total protein, calcium and phosphorus) and determination of bone calcium were done. Five calves were slaughtered and pathological examinations were performed. Observed metabolic, pathological and clinical alterations were compatible with intoxication from Cestrum diurnum. PMID- 9949482 TI - Methamphetamine overdose: experience with six cases. AB - We describe experience with 6 cases of methamphetamine overdose. Because of its low cost, easy availability and longer duration of action compared to cocaine, methamphetamine has become the drug of choice in various communities. Marked change in mental status was observed in all of our patients. One patient had a myocardial infarction that responded well to thrombolytic therapy. Clinicians should be familiar with the medical effects and treatment of acute methamphetamine toxicity. PMID- 9949483 TI - Effect of aluminum phosphide on blood glucose level. AB - Aluminum phosphide (AlP), a poison extensively used as a grain fumigant and rodenticide, can cause an increase or decrease in blood glucose levels Both hypo- and hyper-glycemic effects of AlP can be attributed to the wide variety of changes in magnesium, calcium, phosphate, citrate and cortisol levels. These biochemical changes can act as active stimulatory or inhibitory modulators to enzymes and hormones that catalyze and regulate glucose metabolism. According to the type of biochemical changes, AlP can cause either elevation, decrease or no change in blood glucose levels. A case of AlP-caused death is reported. PMID- 9949484 TI - Retama raetam W: a poisonous plant of North Africa. AB - Poisoning of livestock by ingestion of Retama raetam W, a common plant in arid countries of North Africa, is reviewed. PMID- 9949485 TI - Toxicity and adverse reactions to some drugs in dromedary (Camelus dromedarius). AB - Dromedaries are particularly susceptible to toxicity from certain drugs at doses harmless to other ruminants. The pharmacokinetics of drugs may be different in dromedary and in cattle. This paper reviews the toxicity and adverse reactions of certain therapeutic agents to dromedary. PMID- 9949486 TI - Deer velvet antler: some unanswered questions on toxicology. AB - Deer velvet antler is marketed as a remedy for a wide range of disorders. However, there is a lack of information in the scientific literature to support these claims, and there is also a lack of information on potential toxicity. Areas of potential concern include drug residues, possible deleterious androgenic effects on fetuses and neonates and allergic reactions. PMID- 9949487 TI - Calls on reproductive and developmental toxicants to a regional poison center. AB - We sought to characterize calls received by a regional Poison Center concerning reproductive hazards and to assess the quality of the responses. Data was extracted for a 3 mo period from all calls regarding reproductive or in utero developmental effects. The Poison Center responses were evaluated based on completeness of information gathered and final recommendations made. Two hundred seventy-one calls regarding 335 products were received. Ninety-seven percent of the calls concerned exposures during a pregnancy. Fifty-nine percent of the substances of concern were drugs; 32% were other chemicals; 7% were biological agents. Eleven percent of the exposures were occupational; 22% were environmental. Thirty-four percent of the exposures had not yet occurred. Sixty two percent were characterized as no or minimal risk. For 13% of exposures, callers were advised to avoid initiating or continuing the exposure. Callers were referred to physicians or specialty services for 11% of exposures. The majority of responses were felt to be appropriate. Problematic areas included inconsistent advice and lack of referral. Discussion of exposures in light of other risk factors for and background rates of adverse reproductive outcomes, as well as more frequent referral to a specialist with expertise in reproductive toxicology was recommended. PMID- 9949488 TI - Trends in ipecac use: a survey of poison center staff. AB - The steady decline in syrup of ipecac used by poisoned victims from a peak of 15% in 1985 to 2.3% in 1995 is of concern. A survey compared syrup of ipecac use by CSPI, ABAT, and ABMT/ACMT members as the first response decontamination. The survey asked CSPI, ABAT, and ABMT/ACMT members their professional opinion on the use of syrup of ipecac in a potentially toxic ingestion. The scenario was "Your 2 y-old child/grandchild accidentally ingested a potentially lethal dose of poison (i.e. colchicine) 5 min ago and you have syrup of ipecac at home. Would you consider using it?" Of the 171 CSPI's who responded, 34.5% favored the use of syrup of ipecac while 63% were against and 2.3% needed more information. Of the 26 ABAT's who responded, 50% favored it's use, 42.3% would not and 7.6% needed more information. From the 55 ABMT/ACMT members who responded, 81.8% would use ipecac while 18.1% would not. ABMT/ACMT members favored the use of syrup of ipecac in this scenario (P < 0.005), while the CSPI's did not (P < 0.005), and the ABAT's did not have statistical difference. With CSPI's providing the treatment recommendations from poison centers, it is important that ABMT/ACMT members influence the recommended treatment protocols. PMID- 9949489 TI - Equine granulomatous enteritis linked with aluminum? PMID- 9949490 TI - [Detection of tetracycline- and erythromycin-resistant urogenital Mycoplasma strains using PCR]. AB - The use of PCR made it possible to obtain data on the occurrence of genital mycoplasms in subjects with different pathological states of their urogenital system. The detection rate of U.urealyticum was 10.7-25.1% in males and 23.0 61.9% in females. The detection rate of Mycoplasma hominis was 6.2-11.4% in males and 3.8-22.9% in females. The detection rate of M.genitalium was 6.2-29.6% in males and 4.7-30.0% in females. The study carried out by means of amplification test systems for the detection of genes controlling resistance to tetracycline (tet-M and tet-O) and to erythromycin (erm) demonstrated that U.urealyticum contained the tet-determinant in 60% of cases and M.hominis, in 57.14% of cases. As revealed with the use of PCR techniques, the occurrence of erythromycin resistant Ureaplasma strains was not high and was equal to 2.1%. PMID- 9949491 TI - [Experimental evaluation of the antibacterial activity of tomato pulp oil extract]. AB - The antibacterial action of the oil extract obtained from tomato pulp has been studied with the use of museum strains Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 5638-P and Candida albicans ATCC 885-653, recommended for the determination of the antibacterial activity of medicinal preparations (State Pharmacopoeia, edition XI), as well as Enterobacter, Streptococcus, Staphylococcus, Klebsiella and Escherichia clinical strains. As revealed in this study, tomato pulp oil extract produces a wide-spectrum antibacterial effect on Gram-positive and Gram-negative microorganisms and on fungi of the genus Candida. The study has determined that this antibacterial action is linked with the presence of a complex of organic acids (succinic, citric, tartaric, etc.). PMID- 9949492 TI - [Capsule formation in Pasteurella multocida, serovar A]. AB - In this work the process of capsule formation in P.multocida bovine strain, serovar A, has been studied. The cultures were grown on liquid and solid nutrient media prepared on the basis of Hottinger hydrolysate and synthetic culture medium 199. Extracellular material was detected by the method electron cytochemistry with ruthenium red and polycationic ferritin. As revealed by specific staining and labeling, P.multocida capsule of serovar A was found to contain material of the polysaccharide nature. But the capsular structures of obtained from agar grown and broth cultures were different. The capsular layer on the surface of cells grown in Hottinger's broth was found to be more pronounced. PMID- 9949493 TI - [Effect of the thermostable toxin of Yersinia pseudotuberculosis on the oxidant and antioxidant activity of human blood leukocytes]. AB - Y.pseudotuberculosis thermostable lethal toxin as shown to affect the functional activity of human blood leukocytes. Still neutrophils and monocytes exhibited different reaction to the introduction of the toxin. In monocytes, the toxin in a dose of 0.2 microgram/4 x 10(4) cells inhibited the formation of active forms of oxygen (AFO) and activated the production of superoxide dismutase (SOD). In neutrophils, the toxin affected only the activity of glutathione reductase, inducing a decrease in its activity. The toxin, depending on its dose, stimulated a rise in the level of cyclic adenosine monophosphate (cAMP) in mononuclear cells, but inhibited it in neutrophils. When the toxin was introduced together with indomethacin (10(-7) M), the level of cAMP increased in mononuclears and decreased in neutrophils in comparison with the action of the toxin, introduced alone. Indomethacin prevented the action of the toxin on mononuclears with respect to AFO, SOD and cAMP, which was indicative of the mediating role of prostaglandins in the mechanism of the action of the toxin. PMID- 9949494 TI - [Immunosuppressive action of lipopolysaccharide S- and R-forms of Salmonella and the role of lipid A]. AB - The immunosuppressive activity of extracellular and water-phenol lipopolysaccharides (LPS) of S.minnesota in S- and R-forms, as well as their gel filtration, polysaccharide and lipid fractions, was studied in mouse experiments on the model of delayed type hypersensitivity (DTH). The study revealed that the extracellular LPS of S-form S.minnesota was capable of suppressing DTH with lipid A playing the decisive role in this immunosuppressive activity. The extracellular LPS of Reform S.minnesota did not possess the capacity for immunosuppression, but acquired it after redox treatment. PMID- 9949495 TI - [Effect of technogenic pollution on bacterial biocenoses of a water reservoir]. AB - The industrial pollution of a water reservoir (the Volga), both indirect and direct, not exceeding the highest admissible level, has been shown to lead to the transformation of water microbial associations. The total amount of bacteria increases simultaneously with the decrease of their specific diversity, the ratio of the members of different microbiocenoses changes towards an increase in the proportion of bacteria, resistant to stress influences, which may lead to the growth of the epidemic danger of the polluted areas of the water reservoir. PMID- 9949496 TI - [Interactions between bacteria of the genus Yersinia in a water environment]. AB - Under the conditions of a prolonged experiment in sterile water at 4-6 degrees with no outside supply of any substances pathogenic Y.pseudotuberculosis, Y.enterocolitica and other Yersinia species in pure and binary cultures remained viable for the period of 12-24 months (the term of observation). In monocultures, all Yersinia actually returned to their initial amounts. In associations with Y.enterocolitica O:3, Y.frederiksenii and Y.intermedia, a delay in the lag-phase (1-2 weeks) was observed in Y.pseudotuberculosis, while in the other pair they stimulated the lag- and log-phase in Y.enterocolitica O:8. In other associations, the growth of different cultures was balanced; 12 and 24 months later their amount characteristics exceeded the initial ones by 2-4.9 and 1-3.5 orders respectively. The possibility of interaction with the signs of protocooperation between different Yersinia cells under natural conditions is discussed. PMID- 9949497 TI - [Analysis of Vibrio cholerae hemolysins using monolayer continuous cell cultures]. AB - The comparative study of the preparations of V.cholerae hemolysins of different serovars with the use of continuous cell lines CHO-K1, Vero, Hela, L-929 was carried out. The preparations of hemolysins isolated from such strains as V.cholerae 569B, V.eltor 9949, V.cholerae O-mut 461/67-34 differed in their biological activity on experimental animal models and had different cytotoxic activity. The preparations exhibiting no activity when tested in vivo (V.cholerae and V.eltor hemolysins) were cetotoxins, but in lower doses (1000 and 100 times respectively) than the preparation of V.cholerae O-mut hemolysin, active in vivo. Hemolysins induced the formation of anticytotoxic antibodies in low titers. PMID- 9949498 TI - [Persistence factors in the biological characterization of Neisseria gonorrhoeae]. AB - The study revealed the existence of differences between various representatives of the genus Neisseria gonorrhoeae, as well as intraspecific variations of N.gonorrhoeae by the spectrum of biological characteristics, including antilusozyme and anticomplement activity and resistance to the bactericidal action of blood serum and to the preparation of human leukocyte interferon. In contrast to other Neisseria species, all N.gonorrhoeae were characterized by a high level of anticomplement activity and resistance to the host's bactericidal systems, while a high level of antilysozyme activity, significantly exceeding that of gonococci, was found to be characteristics of other species of the genus Neisseriaceae. Within the species N.gonorrhoeae, the properties under study were associated into a single factor, closely correlated to the duration of the infectious process, which served as the basis for the development of a mathematical algorithm for the identification of persisting gonococcal strains. PMID- 9949499 TI - [The main trends in the improvement of the activity of plague control institutions in the prevention of quarantine infections]. PMID- 9949500 TI - [Organization and tactics of anti-epidemic measures under conditions of natural disasters (as exemplified by the earthquake of 1988 in Armenia)]. PMID- 9949501 TI - [Legal basis of vaccine prophylaxis in Russia]. PMID- 9949502 TI - [Vaccine prophylaxis of measles, rubella and epidemic parotitis]. PMID- 9949503 TI - [Proteins of the complement system in normergy and anergy on mycobacterial antigens]. AB - The influence of the immunization of mice with different doses of BCG (Mycobacterium bovis) vaccine strain on the state of their complement system was studied. The presence of essential differences in the functional activity of proteins in the development of the state of anergy and in normal immune response was established. The animals with the opposite sensitivity to M.bovis were found to have not only initially different levels of the activity of complement proteins, but also different variants of the reaction of their complement system in response to the injection of BCG vaccine. The state of anergy was characterized by an increase in the total activity of the classical activation path and simultaneously by the tendency to a decrease in functionally active molecules of some components of the classical path. The states of anergy and normal response differed in the links and character of relationships between components. Thus the functional state of the complement system was closely linked with the type of immunobiological processes in the cell element of immunity. PMID- 9949504 TI - [Comparative analysis of general and local immunoreactivity in patients with chronic vulvovaginitis of mixed etiology]. AB - The clinical and pathogenetic importance of local immunity in patients with chronic vulvovaginitis (CVV) caused by fungi of the genus Candida or by mixed microflora was studied. 73 patients were examined during the period of exacerbation and 11 patients, at the phase of the remission of the disease. The levels of interferon, interleukin 1 beta, interleukin 8 and tumor necrosis factor alpha in vaginal washings (VW) were determined for the evaluation of local reactiveness and the subpopulation composition of peripheral blood lymphocytes was established. Patients with CVV in the phases of exacerbation and remission were found to have essential differences in the content of cytokines in VW, while the results obtained in the groups of patients at the stage of remission and control subjects were found to be highly similar. PMID- 9949506 TI - [Use of specific antibodies, labeled with colloidal gold particles, for the detection of Brucella antigens using dot-immunoassay]. AB - The method of dot immunoassay with the use specific antigens, labeled with colloidal gold particles, for the detection of brucellar antigens was developed and tested under laboratory and field conditions. In this work soluble antigens isolated from different Brucella species and corpuscular antigens (13 strains belonging to 7 species of the genus Brucella, most pathogenic for humans and animals in the S- and R-forms) were used. The method was tested in the study of pathological material obtained from sick animals and humans in a farm with unfavorable situation for brucellosis in the Irkutsk Region. The sensitivity of the proposed assay system was found to be high and constituted 10 pg/ml to 1 ng/ml for soluble brucellar antigens and 200 CFU/ml to 13.5 x 10(6) CFU/ml for corpuscular antigens of Brucella S- and R-forms. The specificity of the method was tested with the use of 10 heterologous microorganisms. False positive results were observed only with Yersinia enterocolitica 0:9 at a concentration of 1 x 10(6) CFU/ml due to similarity of their polysaccharide-containing surface antigens. The newly developed dot immunoassay is simple for use, rapid and does not require expensive reagents and equipment. PMID- 9949505 TI - [Specificity of a panel of monoclonal antibodies to group A Streptococcus polysaccharide and search for cross reactions with mammalian tissues]. AB - A panel of monoclonal antibodies (McAb) to different determinants of group A Streptococcus polysaccharide (A-PS) has been studied. As revealed in this study, A-PS contains at least 4 determinants, common with different epidermal antigens. McAb, cross-reacting (CR) with different mammalian tissue antigens, have not been found to be group-specific. Experiments on the inhibition of the immunoenzyme reaction of McAb with A-PS indicate that CR determinants include rhamnose and beta-N-acetyl-D-glucosamine of rhamnose alone. In addition, we have confirmed our earlier suggestion that group-specific high-affinity precipitating antibodies acted on different sites of A-PS. Contrary to earlier opinions, antibodies to group-specific determinants of A-PS have been found not to react with epidermal antigens. PMID- 9949507 TI - [Safety of bacteria of the genus Bacillus, forming the base of some probiotics]. AB - The study of the safety of bacillary strains forming the base of new probiotics (biosporin and subalin) was made. For control, the safety of Bacillus sp. IP5832 (the base of the preparation of bactisubtil) was studied. The results obtained in this investigation demonstrated that the strains contained in biosporin and subalin were safe when injected intravenously and intraperitoneally into animals in dose of 5 x 10(9) cells per 0.5 ml of physiological saline. The introduction of Bacillus sp. IP5832 in the same dose produced 100% lethal effect. PMID- 9949508 TI - [Importance of the eradication of the focus of infection and the synchronized correction of disturbed intestinal microflora in shigellosis patients]. AB - The dynamic study of the characteristics of serum specific Shigella endotoxinemia was carried out in 60 patients with S.flexneri infection by EIA techniques. In addition, the level of Re-glycolipid in the blood of patients was determined in EIA with the use of Re-antibodies with the simultaneous study of the rectal microbiocenosis. The degree of dysbiotic disturbances in the intestine was found to be directly related to the levels of LPS of S.flexneri 2a O-antigens and Re glycolipid of Gram-negative bacteria, circulating in the blood. In the presence of decompensation disturbances of intestinal microflora, delayed Shigella elimination was observed in 15% of the patients and the prolongation of clinical manifestions, in 79.2% of the patients. This investigation demonstrated the expediency of complex therapy with the use of the probiotic bifidumbacterin forte, containing bifidobacteria adsorbed on activated carbon and capable of decreasing the level of endotoxinemia and correcting damaged microbiocenosis. PMID- 9949509 TI - [Viral hepatitis delta in the republic of Belarus]. AB - 26,740 blood donors and persons of high risk groups with respect to HBV infection, residing in different regions of Belarus, were examined for the presence of HBsAg in 1983-1997. Of these, 1372 persons (5.1%) were found to have HBsAg, and out of 1081 HBsAg-positive persons anti-HDV antibodies (Ab) were detected in 96 persons (8.9%). In spite of a decrease in acute virus hepatitis B morbidity and in HBsAg carriership, the occurrence of anti-HBV Ab remained stable during the period of 16 years and was equal, on the average, about 4% among asymptomatic HBsAg carriers. Patients having tuberculosis, rheumatoid arthritis, diabetes mellitus, hematological diseases, chronic hepatitides and cirrhosis of the liver were an important reservoir of HBV and HDV infections for regions with the low level of the spread of HBV. A decrease in the detection rate of anti-HDV Ab in patients with cirrhosis of the liver from 47.6% to 15.4% was noted. In 1991 1997 a decrease in the detection rate of anti-HDV Ab in patients with chronic hepatic lesions in comparison with 1983-1990 was observed, and in the age group older than 50 years this decrease was from 33.3% to 8.3%. This difference was particularly pronounces in patients with cirrhosis of the liver: 53.9% and 7.7% respectively. PMID- 9949510 TI - [Comparative evaluation of the level of diphtheria antitoxin in blood serum using four methods]. PMID- 9949511 TI - [Biological tests for the differentiation of Leptospira species]. PMID- 9949512 TI - [Occurrence of clinical strains of Klebsiella pneumoniae inactivating secretory IgA]. PMID- 9949513 TI - [Effect of hydroxylamine hydrochloride on the bacterium Shigella dysenteriae 1 and antigens isolated from them]. PMID- 9949514 TI - [Fraction composition and immunochemical properties of acellular pertussis vaccine]. PMID- 9949515 TI - [Practical use of adapted Salmonella bacteriophage for the treatment and prevention of nosocomial infections]. PMID- 9949516 TI - [Comparative capacity of human mononuclear phagocytes loaded with small doses of antigen to bind it and to induce a lymphocyte proliferative response]. PMID- 9949517 TI - [Modern views on the molecular biological foundations of the pathogenesis of Shigella infections]. PMID- 9949518 TI - [Mechanisms of the uropathogenicity of bacteria]. PMID- 9949519 TI - [Protein antigens of Branhamella (Moraxella) catarrhalis and Neisseria meningitidis]. PMID- 9949520 TI - [Yeast-like fungi of the genus malassezia (Pityrosporum) and their role in human pathology]. PMID- 9949521 TI - [Effect of pectin on the microflora of the gastro-intestinal tract]. PMID- 9949522 TI - [Microbiologic and population-genetic aspects of the pathogenicity of bacteria]. PMID- 9949524 TI - [An outbreak of hospital salmonellosis]. PMID- 9949523 TI - [A rare epidemic outbreak of acute intestinal infections among adults (Part 1)]. PMID- 9949525 TI - [A rare epidemic outbreak of acute intestinal infections among adults (Part 2)]. PMID- 9949526 TI - [Festschrift in honor of Leonid Grigor'evich Voronin (1908-1983)]. PMID- 9949527 TI - [The specific nature of the color and brightness components of the human visual evoked potential]. AB - In order to gain an insight into the electrophysiological cortical mechanisms of color discrimination and to compare the results with psychophysiological data summarized in the previous publications as the spherical model of color discrimination a problem was specified to identify color and brightness components of human evoked potentials. The experiments were carried out with alternating pairs of light flashes constituted of five colors (white and four main colors; red, blue, yellow, and green). Each of the light stimuli varied by seven brightness levels. Color and brightness components (N87 and P120, respectively) were reasonably reliably detected in all cases of substitution of stimuli with identical or different spectra. However, the latency and amplitude analysis of N87 and P120 components in these cases showed that N87 reflects not only color but also brightness information. It makes it possible to draw on the analogy between the N87 as one of the earliest components and N1 in primate cortical evoked potential and suggest that these components reflect the activity of cells receiving information directly from the lateral geniculate body. This process can be considered as the first stage of cortical analysis of chromatic and achromatic light characteristics. The brightness component P120, probably, represents the activity of cortical cells related to the analysis of nonchromatic stimuli characteristics, such as form, movement, orientation, etc. These characteristics are also based on luminance gradients and contrasts, however, in contrast to N87, these characteristics are not directly related with brightness of light. PMID- 9949528 TI - [The characteristics of the color perceptive space in protanomals]. AB - Color vision of three protanomal subjects was studied by means of direct paired comparison technique using 25 colors with different brightness. It was shown that the characteristics of their color vision could be completely and adequately described in the frames of the four-dimensional spherical model of color perception. The spatial axes could be identified as the two color-opponent mechanisms (red-green and blue-yellow) and the two achromatic mechanisms (brightness and darkness). Deformation of the color axes in protanomals (as compared with the normal trichromatics) was demonstrated in the "red" and "yellow" spectral region. The visual disturbance in protanomal subjects involves not only color but also achromatic mechanisms. This is manifested in the a deformation of perceptual brightness scale. In comparison with normal trichromatic subjects, the protanomals perceive the red and adjacent colors as achromatic while green, yellow-green, and orange as more bright but low-saturated colors. PMID- 9949529 TI - [Human visual evoked potentials during the recognition of facial emotional expression]. AB - Visual evoked potentials (VEPs) were recorded in 22 right-handed healthy subjects in the occipital, parietal, central, frontal and posterotemporal cortical areas during recognition and passive viewing of positive, negative, and neutral emotional facial expression. Peak latencies of N90, P150, and N180 VEP components appeared to be significantly shorter in response to the negative emotional expression than during administration of other facial stimuli. The differences were observed both during active recognition and passive viewing. Correct recognition was characterized by involvement of both hemispheres and high level of interhemispheric correlation between the peak latencies of P150 in the posterotemporal and of N180 in the frontal areas. It is suggested that the facial expressions are primarily recognized at the subthreshold level with participation of the posterotemporal areas. The role of the frontal areas is discussed in the completion of this process and making the correct decision about the image. PMID- 9949530 TI - [Visual evoked potentials to illusory contours (Kanizsa's square)]. AB - Visual evoked potentials (VEP) were studied in 10 subjects to presentation of illusory Kanizsa's square and control visual stimulus with similar spatial organization, which did not produce a visual illusion. The VEPs to the applied stimuli were expressed in the occipital, parietal, and inferiotemporal areas. It was shown that during presentation of the illusory configuration the amplitude of VEP variation between the N180 and P230 peaks was higher and the N300 latency lower than during presentation of stimuli with real configuration. The difference between VEPs in amplitude were observed in the left and right occipital and left inferiotemporal areas, and differences in latency were pronounced in the left occipital derivation. It is suggested that there exist two contour-encoding regions in the visual system which participate in different kinds of the visual analysis. First, associative visual fields which encode the information on single sings and their complexes and inferiotemporal fields which compare the sensory and memory codes. PMID- 9949531 TI - [The temporal consistency of phasic conversions in the basic frequency components of the EEG]. AB - The study is dedicated to the problem of piecewise description of stationary segments of the EEG basic rhythms. Temporal consistency was studied of the moments of sharp changes in characteristics of the individual basic EEG frequency components within the same realization. In 6 human subjects (in the state of quiet wakefulness with eyes closed) a rather high number was shown of nonrandom paired coincidences of the moments of sharp changes in characteristics of 5 EEG basic rhythms. Such between-component consistency was most expressed for a combination of alpha2-beta1 frequency ranges. The main topographic feature of this phenomenon was a substantial (2-4 times) increase in the indices of between frequency consistency from the occipital to frontal areas. The character of changes in these indices was closely the same in 10 paired combinations of the EEG frequency bands, at least in the frontal and central derivations. The obtained results suggest the existence of a special operational synchrony of the EEG basic rhythms. In contrast to the classical phase-frequency synchronization, this kind of synchrony reflects the temporal consistency of quasistationary modes of brain activity. PMID- 9949532 TI - [The neurophysiological aspects of the recurrent functioning of the "hidden" variables of the speech apparatus]. AB - The "hidden" recurrent structure is established of temporal organization of acoustic speech signal. Such "hidden" recurrence can be revealed only due to experimentally established existence of two qualitatively different modes in the temporal organization of stutterers' speech. A theoretical model of speech generation is developed with a logistical property of "hidden" parameters in order to explain this phenomenon. This model is stated in terms of chaotic dynamics and is based on the neurophysiological striopallidal mechanisms which are realized under conditions of polysensory afferent impulsation. The effects of speech memory and actualization of its traces are explained on the basis of our earlier concept of perception of the rhythmical speech sequence. This concept allowed us to discuss the experimentally observed phenomenon of inhibitory modulation under conditions of both ipsi- and contralateral global negative feedback. PMID- 9949533 TI - [The retrieval of attention-dependent long-term memory traces]. AB - Phenomenon of memory dissociation is proposed as a paradigm for studying the retrieval processes of the long-term memory. The memory-dissociated states of brain are produced by external influence and result in selective reversible disturbances of the retrieval processes without substantial changes in perception and storage of new information. Analysis of dissociated states induced by pharmacological influences has led us to the following conclusions: 1) the reversible failures of the retrieval processes are usual for the attention dependent form of long-term memory, 2) hippocampus is the key structure in brain mechanisms that realize the engram selection during memory retrieval, 3) the central cholinergic and GABAergic systems regulate the retrieval of information, 4) steady disturbances of retrieval of the long-term attention-dependent memory are accompanied by strongly pronounced changes in hippocampal cells including those at the membrane and genomic levels. PMID- 9949534 TI - [The cytochemical indices of the sensorimotor cortex neurons in rats differing in their trainability in a food-acquiring habit]. AB - Comparative study of protein metabolism in neurons of layers III and V of the sensorimotor cortex was carried out in two groups of Wistar rats, which differed in learning results: "bad" (60% of population) and "good" learners (40%). It was found out that the associative neurons (layer III) were most sensitive to cognitive load. In "bad" learners, an increase in nuclear and cytoplasmic dimensions and rise in protein concentration and content took place in these neurons, while in the efferent neurons (layer V) the protein content increased only in the cytoplasm. In "good" learners, the cognitive load led to a decrease in all the cytochemical parameters in neurons of the layer III while in the neurons of the layer V the content and concentration of proteins increased both in nuclei and cytoplasm. It is suggested that the character of protein metabolism changes produced by information load can be considered as a reflection of individual peculiarities of cognitive activity, and the extent of cytochemical changes as a reflection of complicity of a cognitive task. PMID- 9949535 TI - [Teaching hooded crows (Corvus cornix L.) the abstract rule of choice by the matching/oddity of the sample]. AB - Six hooded crows (Corvus cornix) were trained in alternative simultaneous matching-to-sample and oddity-from-sample tasks with visual stimuli. Bird's ability to acquire the abstract same/different concept was investigated. For this purpose three stimulus sets of the following categories were used: color (black and white cards), shape (Arabic numerals "1" and "2"), and numerousness (heterogeneous arrays of 1 or 2 elements). These three sets were used for training successively and repeatedly; each time the stimulus set was changed for the next one after the criterion (80% correct or better over 30 successive trials) was reached with the previous one. The training procedure was repeated until the criterion could be reached for each of the three stimulus sets within the initial 30-50 trials. After that, the abstractness of the rule acquired by birds was tested. First, the "partial" transfer tests were conducted, which consisted in presentation of novel stimuli with familiar ones (numerals and arrays in the range from 1 to 4). At the final stage, only sets of novel numerals and arrays in the range from 5 to 8 were presented. The crows demonstrated successful transfer in all of these tests, including the test with absolutely novel stimuli (in the first 24 presentations: min 75.0%, p < 0.02; max 83.3%, p < 0.01). The level of correct choices did not differ from the baseline (p > 0.05). This allows us to conclude that birds are capable for formation of the abstract same/different concept. PMID- 9949536 TI - [The dynamics of the integral parameters of orienting-exploratory and searching behaviors in rats]. AB - Multiple five-day testing of rats in the open field and elevated plus-maze revealed a regressive dynamics of the integral characteristics of the exploratory behavior. The integral quantitative indices of searching activity in Henderson's test of extrapolation deliverance (modified by N. A. Bondarenko) and in active shock avoidance in N. R. Grigor'ev's problem box, on the contrary, displayed a progressive dynamics, like quantitative characteristics of cognitive activity. We established the differences between the determinants and control mechanisms of exploratory behavior and searching activity. This allowed us to differentiate these forms of behavior as different functional states. PMID- 9949537 TI - [The mechanism of movement instrumental learning in a Hopfield environment in the feline motor cortex]. AB - A model of the neuronal processes in the motor cortex is proposed, which provides the mechanism for instrumentalization (voluntary reproduction) of movements primarily evoked by stimulation of the parietal cortex. The main propositions of the model are as follows: the late NMDA-dependent response of the motor cortex neurons to stimulation of the parietal cortex reflects the discharges in the recurrent collaterals of the pyramidal cell axons; learning processes in the motor cortex are based on the long-term potentiation of the efficiency of the recurrent collaterals; the Hopfield's theory of neuronal nets is applied to the processes of motor learning in the cortex. The movement instrumentalization is viewed as the stable state formation in the collaterally linked neuronal structure; the voluntary reproduction of the previously learned movement in considered as the process of transition of the neuronal structure into the stable state. The data on acetylcholine and dopamine modulatory influences on the reactions of motor cortex neurons are discussed. PMID- 9949538 TI - [Reciprocal suppression of the AMPA and NMDA components of the excitatory postsynaptic potentials in the CA1 area of the rat hippocampus in vitro]. AB - The interaction between N-methyl-d-aspartate (NMDA)- and alpha-amino-3-hydroxy-5 methyl-4-isoxazole propionic acid (AMPA)-dependent components of excitatory postsynaptic potentials (EPSP) was studied in rat hippocampal slices. Responses evoked by stimulation of the collateral commissural fibers were recorded in the radial layer of the CA1 area. Contribution of the NMDA component was changed by application of solutions with different concentrations of magnesium. In solutions with low magnesium concentration, when both AMPA and NMDA components contribute significantly to EPSP, suppression of one of the components by application of selective antagonist resulted in increase in the area of another component. Thus, the sum of pharmacologically isolated AMPA and NMDA components was significantly higher than the control EPSP. For example, at 0.1 mM of magnesium in the extracellular solution the sum of the components was 340 +/- 120% of the control EPSP (p < 0.01, N = 6). The data imply that under the control conditions the EPSP components suppress each other. The mutual suppression of the AMPA and NMDA component of the EPSP can be an important factor which influences the conductivity and plastic properties of central glutamatergic synaptic pathways. PMID- 9949539 TI - [The effect of atropine on the ultrastructural postsynaptic plasticity of the associative type in the rat neocortex]. AB - The effect of muscarinic antagonist atropine on thickness of postsynaptic density of axodendritic synapses was studied in the sensorimotor region of the brain cortex of rats during paired repeated microapplication of glutamate and acetylcholine. In the applied conditioning paradigm atropine significantly decreased morphological dimensions of the postsynaptic density, however, the control values were not reached. This finding testifies to participation of both muscarinic and nicotinic cholinoreceptors in associative postsynaptic plasticity. PMID- 9949540 TI - [Electrode implantation for the recording of brain electrical activity causes long-term changes in rat behavior]. AB - Comparative evaluation was carried out of behavior of rats with implanted brain electrodes and animals without electrodes. In rats with implanted electrodes the anxiety-phobic level was increased, open-field locomotor activity and rearings were decreased, novelty reactions on illumination changes and zoosocial interactions were deranged. The behavior remained altered for at least 3 weeks after surgery. PMID- 9949541 TI - [Motor and sensory asymmetry in rabbits]. AB - The obtained results testify to the existence of motor asymmetry in rabbit population: right turns in free behavior dominated in 58% of animals (31 rabbits were examined), left turns dominated in 23%. Sensory asymmetry (preference of a certain eye in exploratory activity) was found in a small number of animals, right eyes dominated in 23% of them, and left eyes in 10%. PMID- 9949543 TI - Is there a borderline between reconstructive and aesthetic surgery? AB - Plastic and reconstructive surgery is frequently mistaken for aesthetic and cosmetic surgery. At present, plastic surgery is a very broad discipline in which aesthetic surgery is an integral part. The majority of reconstructive operations, in particular on the body surface, include an aesthetic component. Their purpose is not only the restoration of function but also the achievement of optimal aesthetic results. The authors demonstrate examples on the vague borderline between functional and aesthetic reconstruction and present their views on the medical indication for these operations. PMID- 9949542 TI - [Spatially selective neurons of the prefrontal cortex of monkeys in delayed reaction to stimulus approach/removal]. AB - The neurons which selectively reacted to approaching vs. removal of the visual stimulus were described. These selective properties were shown to be fixed in the operative memory. PMID- 9949544 TI - Surgical treatment of ankyloses of the temporomandibular joint in children. AB - Ankylosis of the temporomandibular joint leads in children to serious disorders such as loss of dentition, growth retardation of the lower jaw, facial asymmetry etc. During the period from 1993 till 1997 we treated 12 children incl. eight who had unilateral and four bilateral ankylosis. In six patients, after elimination of the ankylosis, reconstruction of the head was made with a total of nine costochondral grafts. In entire all patients the temporal muscle or a silicone plate was interposed between the skull base and mandible. Postoperative complications were minimal. Surgical treatment, which is only half of the issue of treatment, must be followed by long-term careful rehabilitation. The results which were achieved contributed in a significant way to a more favourable further development of the children. PMID- 9949545 TI - Bacteriological monitoring in the Prague Burns Center. AB - The microbiological aspect of the prevention of nosocomial infections at the Burn Center consists primarily in the surveillance of bacterial flora and its antibiotical resistance. The Prague Burn Center is regularly monitoring the microbial flora. Patients are examined not only by the conventional methods of taking swabs of burned sites, but also by printing method, which allows a semiquantitative assessment of the colonization of burned areas. Simultaneously, investigation of bacterial contamination in the external environment of the department is carried out and the colonization of nursing staff is investigated. In all isolated strains the sensitivity to antibiotics is examined; this is significant from the point of view of current knowledge about therapeutic possibilities and for the antibiotic policy. The typing of bacterial strains makes possible to determine their epidemiological markers, and thus to investigate their spread within the department. The most frequent isolate is S. aureus and the prevalence of MRSA is relatively high. Among gramnegative rods the strains of P. aeruginosa, K. pneumoniae and E. cloacae are most often isolated. Various typing methods revealed endemic spread of particular strains of rarely isolated species (E. agglomerans, S. marcescens, A. baumannii, etc.). PMID- 9949546 TI - Congenital contracture of the superficial flexor of the hand. AB - The authors describe a case of an inborn contracture of the superficial flexors of the three-phalangeal fingers in a 15-year-old girl and treatment of the condition. For clinical purposes a classification on congenital deformities in the proximal part of the flexor complex was proposed in which the described case is included. The classification was derived from the ontogenetic development of flexor tendons. There are three types of deformities: S1--the muscular belly of the superficial flexor of the fingers is only in the palm; S2--the muscle is attached to the area between the wrist and medial epicondyle; S3--the palmaris longus of the fingers is on the medial epicondyle, however the m. palmaris longus is lacking; Pl-1 the superficial flexor exists only in the form of a proximal muscular belly of varying length; Pl-2--the palmaris longus is on the wrist and the insertion tendon may be thinner than on the contralateral side. The described contracture deformity was classified as type S2. PMID- 9949547 TI - Environmental pollution and the occurrence of congenital defects in a 15-year period in a south Moravian district. AB - We have made a simple 15-year retrospective epidemiological study of a part of South Moravia, district Breclav, on the basis of genetic documentation of 245 congenital defects and 28 spontaneous abortions. The whole area was worked up by computer-geographical methods, and the occurrence of congenital defects was compared both in areas of severe chronic air pollution and in less contamined areas. There were three municipal areas, Mikulov, Breclav-Postorna, Velke Bilovice and their surroundings, in which an increased number of congenital defects was recorded. In the municipal area of Breclav-Postorna there was also a greater occurrence of organic solvents and phosphoric acid and a significantly higher occurrence of spontaneous abortions and at the same time a higher occurrence of heart defects. PMID- 9949548 TI - Roentgencephalometric analysis of the skulls of the Luxemburgs, the second Bohemian Royal Dynasty. AB - X-ray films of the skull of the king and emperor Charles IV and his four wives and two sons were made under standard conditions with the mandibles fixed in a centric occlusion. The results of roentgenocephalometric analysis were compared with norms valid for the contemporary Czech population. Consistent with the somatic condition of Charles IV, the findings indicate an above-average large face with the usual anteriorotational developmental type. The facial skeleton is structurally harmonious, but the sagittal intermaxillary relations belong into skeletal class II with a relatively retruded lower jaw in relation to the upper one. This is associated with a greater maxillary overjet of the upper incisors. The disharmony was caused by a fracture of the mandibular condyles. Reconstruction of the condition before the injury revealed an originally normal anteroposterior relationship of the jaws (skeletal class I) and occlusion of the incisors. As to the shape of the cranium, Charles IV's wives differ in basic features. In two, for different reasons, we find skeletal class II (retrogenia), in one skeletal class III (progenia) and only in Elizabeth of Pomerania, with marked flattening of the cranial base and posteriorotation of the face are the anteroposterior relations of the two jaws normal (skeletal class I). Wenceslas IV differs from his parents Charles IV and Anne of Svidnic by a flat cranial base which pushes the lower jaw backwards, however, it does not cause its posteriorotation; we find, similarly as in the father and mother, an anteriorotational growth type of the face. In the other basic parameters of the cranium there are no marked differences between son and parents. In evaluating the similarity of the facial structure of John of Gorlitz to that of his parents, disagreement is caused by the flat cranial base of the mother Elizabeth of Pomerania associated with posteriorotation of the face. In the son we find, conversely, an even more marked anteriorotation than in the father and also other parameters of the facial configuration indicating plausible agreement with the findings in Charles IV. The curving of the cranial base has an impact on the shape of the whole cranium, but the results indicate that the heritability of the rotational growth type of face and the degree of cranial base curvature probably is not very marked. PMID- 9949549 TI - Effects of caffeine on NMDA-evoked 45Ca2+ release in the rate dentate gyrus in vivo. AB - Caffeine in 10(-2) M concentration per se activates ryanodine receptors (RyR) in vitro, thereby increasing the intracellular concentration of Ca2+ ([Ca2+]i). In general opinion, caffeine applied in vivo in much lower doses does not affect [Ca2+]i in neurones. However, it was recently demonstrated that caffeine in low concentrations in vitro potentiates evoked Ca2+ release in neurones via RyR. Microdialysis of the rat dentate gyrus (DG), combined with measurement of 45Ca2+ efflux, has been used in our laboratory to study in vivo NMDA-evoked calcium induced calcium release (CICR) via RyR. The aim of the present microdialysis study was to investigate in vivo effects of caffeine, applied systemically in a pharmacologically-relevant dose, and locally in the dialysis medium in very high concentration, on the NMDA-evoked CICR in DG neurones. To ensure steady brain concentration of caffeine, its systemic (i.p.) administration in a dose of 40 mg/kg was followed by a continuous i.p. infusion of 80 micrograms/kg/min and application of 0.4 mM caffeine in the dialysis medium. The results demonstrated that in the rat DG, local administration of 50 mM caffeine significantly stimulates a spontaneous 45Ca2+ efflux and its release induced by 5 mM NMDA. However, systemic administration of caffeine had no effect on spontaneous and NMDA-induced 45Ca2+ release in the rat DG, which supports the view that caffeine, applied in vivo, even in high doses, does not influence CICR in brain neurones. PMID- 9949550 TI - Phosphorylation of protein kinase C substrate proteins in rat hippocampal slices- effect of calpain inhibition. AB - Incubation of the acutely dissected rat hippocampal slices in calcium-containing media resulted in spontaneous activation-translocation of classical PKC isoforms and their subsequent (especially gamma-type) proteolytic degradation. These changes were blocked by calpain inhibitor MDL 28 170 in 100 microM concentration. Rat hippocampal slices were metabolically prelabelled with 32Pi and stimulated with NMDA/glycine, depolarization or phorbol dibutyrate (PDBu) treatment. The basal phosphorylation of specific PKC substrates (MARCKS, neuromodulin and neurogranin) was significantly reduced in non-stimulated slices by MDL pretreatment. In contrast, only the slices where calpain activity was inhibited responded to further NMDA or phorbol dibutyrate stimulation by a substantial increase of PKC-dependent protein phosphorylation. It is concluded that the PKC phosphorylation system is severely affected by non-specific activation and a subsequent, calpain-dependent proteolysis in the acutely prepared hippocampal slices. Calpain inhibition by 100 microM MDL partially prevented these changes and increased stimulus-dependent phosphorylation of PKC-specific protein substrates. PMID- 9949551 TI - Collateral projections of trigeminal sensory neurons to both cerebellar paramedian lobules in the rabbit: demonstration by fluorescent double labeling study. AB - Neurons in the trigeminal sensory nuclei (TSN) were indicated to project simultaneously to the cerebellar paramedian lobule (PML) of both sides by way of axon collaterals in the rabbit. Injections of Fast Blue and Diamidino Yellow made in twelve rabbits into the regions of the left and right PML cortex, respectively, resulted in retrograde double labeling of neurons in the principal trigeminal (Vp) and spinal trigeminal nuclei including subnucleus oralis (Vo), and rostral (Vir) and caudal (Vic) subnucleus interpolaris. Sparse labeling was seen among the root fibers of the facial nerve immediately adjacent to Vp. The data indicated that out of the total population of ipsilateral and contralateral single labeled neurons in TSN subdivisions, double labeled neurons constituted about 11% in Vo, 2% in Vp and Vir, and 1% in Vic. Thus, it seems that out of TSN neurons sending collateral projections to PML of both hemispheres, those in Vo project more frequently than those in Vp, Vir and Vic. The homotopic (corresponding) middle (c and d) PML sublobules receive collateral projections from neurons of all these TSN subdivisions, whereas the caudal (a and b) and rostral (e and f) sublobules seem to be targets of the projection from Vp and Vir. The findings suggest that some TSN neurons may exert simultaneous bilateral modulatory influences upon the regions in various sublobules of both PML. PMID- 9949552 TI - Differential effects of non-REM and REM sleep on sensory gating in rats. AB - Sensory gating in rats can be measured with a double click paradigm. The diminished response towards the second click is a physiological manifestation of reduced sensory input. This physiological process seems to be disturbed in human psychoses. It is thought that gating, as measured with this paradigm, is a preattentive, involuntary phenomenon which is not modulated by attention. If this is indeed the case, than it is hypothesized that gating should not be modulated by non-REM sleep. In the present experiment pairs of clicks (500 ms interval) were presented during wakefulness, non-REM as well as REM sleep and cortical auditory evoked potentials (AEP's) were recorded in chronically implanted rats. Rather similar AEP's were found after the first and second stimulus. However, the amplitudes of the various components of the second AEP were smaller than those of the first AEP, suggesting a gated response. This was the case during all three levels of vigilance. The amplitudes of both AEP's showed the more often reported changes in amplitude during sleep and REM sleep. Clear differences were seen in gating: compared to wakefulness a decrease in gating was found during REM sleep while gating was unchanged during non-REM sleep. The latter outcome seems to confirm that gating in rats is indeed a preattentive process. Finally, results were discussed in terms of neuronal properties of thalamic relay cells and it is suggested that firing properties of thalamic relay cells are not involved in this type of sensory gating. PMID- 9949553 TI - Synaptic excitation of principal cells in the cat's lateral geniculate nucleus during focal epileptic seizures in the visual cortex. AB - Principal cells of the lateral geniculate nucleus are intensely activated during focal seizures in the visual cortex. The intracellular recordings technique from geniculate cells was used to show that this activity is induced by a strong excitatory synaptic input from discharging cortico-geniculate neurones in layer 6 of the cortex. PMID- 9949554 TI - Clock-spiking cells not only in the eye of the fly, but also in the antenna! AB - During the course of single cell olfactory recordings from the funicular part of the antenna of Drosophila virilis we encountered a pair of cells firing synchronously and consistently at a rate of about 9 to 14 spikes per second. Every spike was seen to consist of a spike complex made up of two separate biphasic components thought to originate from two separate cells. The larger action potential, appearing first, had a peak-to-peak (ptp) amplitude of up to 200 microV followed closely by a smaller spike with an amplitude of about 60 microV. The repetitive firing pattern was not affected by air or odour puffs. This kind of consistent spontaneous spiking activity of two closely associated cells resembles remarkably closely the clock-spikes hitherto known only from the eyes of flies. Our encounter with such cells in a sense organ other than the eye poses many new questions and could lead to a renewed effort to understand the role(s) of the clock-spiking cells as possible oscillatory components of the dipteran pacemaking system in particular and the insect nervous systems, generally. PMID- 9949555 TI - Insulin impairs the anticonvulsive activity of carbamazepine against maximal electroshock-induced seizures in mice. AB - In view of the data indicating that insulin can modify penetration of some drugs across cell membranes and tissue barriers, particularly the blood-brain barrier, the aim of the present study was to evaluate the effect of insulin on both the anticonvulsant activity and the brain concentration of carbamazepine in mice suffering from seizures induced by maximal electroshock. The antiepileptic drug was administered per os in single doses either alone or in combination with insulin given as single intraperitoneal injections. To assess the anticonvulsant activity of carbamazepine the ED50 values were calculated. The results indicate that insulin given in doses up to 2 units/kg did not affect the convulsive threshold, whereas insulin applied at 2 units/kg led to a significant reduction in the anticonvulsant activity of carbamazepine, as judged by an increase in the ED50 value from 16.2 to 41.3 mg/kg. This effect was accompanied by the marked reduction in both the brain and blood concentrations of the drug. It is likely, therefore, that the inhibitory activity of insulin on the anticonvulsive function of carbamazepine is related not only to the effect of the former on the blood brain transport of the latter, but also to insulin-induced modulation of the serum concentration of the drug. PMID- 9949556 TI - Possible natural circaseptan rhythm in the beach beetle Chaerodes trachyscelides white. AB - Activity rhythms in groups of captive beach beetles (Chaerodes trachyscelides White) have been recorded in an actograph over a period of 29 days. Under constant illumination and when no sand was provided for the beetles to burrow in abnormal behaviour occurred. With sand and in constant darkness a strictly nocturnal activity period with apparently circaseptan components superimposed was observed. The beetles in their natural habitat are confined to the debris zone where they feed on washed up seaweed and this debris zone moves up and down depending on the heights of the tides. Circaseptan elements in the beetles' activity may act as adaptations to the weekly alternations between spring- and neap-tides. PMID- 9949557 TI - Effect of experimental setting on learning and performance of Auditory Delayed Matching-to-Sample task in dogs. AB - Twelve dogs were trained in a new task for auditory recognition memory: auditory Delayed Matching-to-Sample (DMS). The animals were tested in two experimental settings using approach (Setting 1) or bar-press (Setting 2) responses. At the early stages of training, the learning took more trials in Setting 2, which was caused by different instrumental response and/or different relationship among manipulanda, stimuli, and reward in these two settings. The performance of the final task did not differ between settings and showed a gradual decline with extended delays. No differences were found in responding patterns or in dynamics of learning. Therefore, we conclude that the auditory DMS, trained in either setting, offers a valuable and reliable tool for studies of neural substrate of auditory recognition memory. The detailed analyses of the dogs' behaviour will allow to evaluate the subtle effects of experimental manipulations in future experiments, and for many reasons the data obtained from these two settings may be combined in further analyses. PMID- 9949558 TI - Experience-dependent changes in vibrissae evoked responses in the rodent barrel cortex. AB - A change in vibrissae complement in rodents leads to long-term changes in vibrissae dominance. These changes involve both potentiation of spared vibrissae responses and suppression of deprived vibrissae responses in adolescent animals. In adult animals only potentiation of spared vibrissae responses was detected. Suppression exhibits hetero- and homosynaptic components and appears to be cortical in origin, as is potentiation. The time course for potentiation and suppression in the barrel cortex of adolescent rats is different, with suppression preceeding potentiation by at least one week. There seems to be no critical period for potentiation in superficial layers of barrel cortex, but there is a critical period for suppression. Suppression cannot be evoked if plasticity is induced later than at 6 months of age nor maintained if experimental manipulations begin later than at three months. The molecular mechanisms that underlie plastic changes in the barrel cortex still remain unclear, although alpha-CamKII and to lesser extend alpha/beta-CREB appear to be involved. PMID- 9949559 TI - Effects of conditioned and predictive stimuli on the fly-away escape response in a two-way shuttle box. PMID- 9949560 TI - [Autism and inter-subjectivity]. AB - The concept of autism as a fundamental symptom of schizophrenia has been lacking of psychiatric eminence in the course of time, just because of its absence of univocal sense, and its extraordinary richness, hardly to be apprehended by deterministic procedures. However, the experience which it refers to, is still present in the daily clinical practice. In its attempt of apprehend this reference, the psychopathology has developed several concepts, as diverse and unspecific as "Praecoxfeeling", "self disorders", or "contact disturbances". In this paper, we start from "Intersubjectivity" as the viewpoint from which we try to comprehend the immediate experience of the Other as a whole. Finally, our purpose would be to offer an interpretation of autism that could serve as a comprehensive substrate for many of the manifestations of the schizophrenic condition. PMID- 9949561 TI - [A study of personality in eating disorders]. AB - Some evidence suggests that temperament and personality traits could influence the development and severity of eating disorders. This study was designed to study these aspects. METHODS: 72 patients with DSM-IV eating disorders including 25 anorexia nervosa restricting type, 17 with anorexia nervosa binge eating purging type and 30 with bulimia nervosa were studied and compared with thirty healthy controls. Personality disorders and temperament were studied with the Eysenck's EPQ, Cloninger's TCI and SCID-II. Impulsive and clinical features were studied with specific rating scales. RESULTS: 61.8% of patients had at least one personality disorder. Avoidant personality disorder was the most commonly diagnosed in anorexia restricting type (25%). Borderline personality disorder was the most frequent in bulimia nervosa and in the binge eating-purging type of anorexia nervosa. Dimensionally, the group of eating disorders presented high scores in neuroticism and low scores in self-directedness. Higher harm avoidance was found in bulimic patients and higher persistence was associated with anorectic patients. Bulimic patients were significantly more impulsive than anorectic and controls. CONCLUSIONS: Temperament and personality traits differ in anorectic and bulimic patients. Bulimic symptoms are linked to impulsive temperament traits and to impulsive personality features. Anorectic symptoms are linked to persistent temperament traits and anxious personality features. PMID- 9949562 TI - [Panic disorder in the elderly]. AB - The existence of panic disorder (PD) in old population is a source of debate. OBJECTIVES: This study is aimed at studying the sociodemographic and clinical characteristics of panic disorder in patients over 60 years of age seen in two outpatient psychiatric clinics. METHOD: All consecutive cases of PD (DSM-III-R) who contacted with two outpatient clinics in a three-year period were assessed by the same team. Those patients aged 60 or more at the time of interview were grouped and compared with a young and adult group. PASS and Marks-Matthews' Phobia Scale were administered to the sample. RESULTS: Fifty-three (15.6%) out of 341 PD patients were over 60 years of age. Elderly patients reported less frequency and severity of symptoms, less comorbidity with social phobia (p < 0.01) and alcoholism disorders (p < 0.01) and more with dysthymia (p < 0.05). The elderly patients with PD reported fewer family histories of alcoholism (p < 0.05), depression (p < 0.05) and PD (p < 0.05). CONCLUSIONS: The rate of PD patients over 60 years of age who get in touch with outpatient psychiatric clinics is variable but not uncommon. Some clinical characteristics of PD in the elderly such as medical comorbidity and less symptom severity may enhance misdiagnosis in clinical settings. PMID- 9949563 TI - [Influence of maternal feeding restrictions on the mother-daughter dyad]. AB - Alimentary restraint, cognitive variable related to eating behavior and obesity, is reportedly a valuable predictor for the development of therapeutic strategies. This paper addresses the relationship between maternal restraint and several psychological variables in their daughters (alexithymia, neuroticism, extraversion). From the study of 35 mother-daughter dyads it can be concluded that daughters of highly restrained mothers tend to present high scores in the Restraint scale of the Three Factor Eating Questionnaire of Stunkard and Messick, translated into Spanish and validated as Cuestionario de Conducta Alimentaria. Daughters of highle restrained mothers present also higher scores in the Neuroticism scale of the revised version of the Eysenck Personality Questionnaire. Daughters of mothers with low Restraint scores are in average higher than those of their mothers, although lower than those belonging to daughters of highle restrained mothers. Previous observations on the positive correlation between Disinhibition and Hunger of the Three Factor Eating Questionnaire are confirmed. These results add an additional risk factor for obesity (mothers with high Restraint) and contribute to delineate a set of psychometric indicators which might be useful in the diagnosis and prognosis of eating and body weight disorders. PMID- 9949564 TI - [Biological markers of schizophrenic symptoms: functional neuroimaging]. AB - Despite heterogeneous phenotype, lack of pathognomonic symptoms and great variability of symptoms during the course of the illness, functional neuroimaging studies have showed specific patterns of activation associated to particular schizophrenic symptoms or symptom dimensions. Negative symptoms have been associated to hypofrontality; auditory hallucinations seem to be related to abnormalities in brain regions involved in language and, reality distortion dimension has been associated to left temporal lobe impairments. PMID- 9949565 TI - [Origin, cognitive meaning and clinical applications in psychiatry of the P300 component]. AB - The P300 component studies, have been generated discussion about his source, cognitive meaning and clinical applications. Since the first point of view, different structures have been proposed as a probable source of P3a or P3b in oddball and memory task and in scalp and in a intracraneal recordings. There are many papers that lucubrate about cognitive meaning of P300 and the applications of this component in the diagnostic process of psychiatric pathology. We make critic analysis and different points of view about this component. PMID- 9949566 TI - [Cerebral infarction in an adolescent girl following an overdose of paroxetine and caffedrine combined with theodrenaline]. AB - Selective serotonin reuptake inhibitors (SSRI) have demonstrated to be effective, well tolerated and relatively safe drugs in cases of overdosage. However, and related to the potentiation of the serotonergic transmission elicited by them, these drugs have been associated by some authors with the possibility of causing vascular complications. Serotonin is a vasoactive substance with complex actions on vessel wall as a result of its interaction with specific receptors existing at this level. We present the case of an adolescent girl who suffered a cerebral infarction after consuming a toxic dose of paroxetine and two other products, one of them containing caffedrine and theodrenaline, and the other one a phlebotonic agent. In connection with the possible pathophysiological mecanism the implied products as well as the serotonergic vascular receptors are briefly reviewed. Finally, a reference is made to Calls syndrome as a possible entity related to the unfortunate event suffered by the patient. As a conclusion risks of the combined pharmacotherapy, especially in cases of overdosage and in child and adolescent populations, are underlined. PMID- 9949567 TI - [Guirod's hebephrenic syndrome: a case report]. AB - Schizophrenia, a psychiatric disease that is highly prevalent among the general population, has polymorphic clinical manifestations at onset and during its evolution. The most frequent manifestations are an abrupt onset with positive symptoms, perception and thought disorders, which were included by Kurt Schneider in the first range symptoms. However, on other occasions the onset is insidious and the so-called negative symptoms are present, resulting in clinical manifestations that are similar to the state of absence and a less favorable patient prognosis. Since the last century when Kraepelin defined early dementia, various authors have tried to explain the nature of this disease, resulting in Bleauler's definition of the fundamental symptoms. A clinical case of hebephrenic schizophrenia is presented in which disorders in thought, affect and volition predominated. We discuss the psychopathological views of less well-known, but not for that reason less important, authors, such as Guirod and Dice, and the similarities and differences between their views and current classifications. PMID- 9949568 TI - [Optimizing intravesical B.C.G]. PMID- 9949569 TI - [High incidence of chromosome 8 monosomy and chromosome 7 trisomy in prostatic primary tumor and its related lymphatic metastasis. Preliminary results]. AB - INTRODUCTION: The research on tumoral aggressivity parameters in prostate cancer, such DNA ploidy detected by fluorescence in situ hybridization, has significant relevance to refine prognostic on an individualized patient. OBJECTIVES: To identify chromosome numeric alterations by FISH in primary prostate cancer focus and its corresponding lymph node metastases. b) To describe a cytogenetic tumoral progression pathway. METHODS: So far, we have retrospectively studies eight patients with prostate cancer and lymph node metastases performing FISH analysis on the primary prostate cancer focus and its metastatic lymph node. DNA probes for chromosomes 7, 8, 10 and 12 have been used for FISH analysis. RESULTS: a) Seven out of eight tumours (85%) were aneuploid when studied by FISH and the most frequent chromosome alterations found were monosomy 8 (100%) and trisomy 7 (85.7%). All the lymph nodes were aneuploid being monosomy 8 (87.5%) and trisomy 7 (62.5%) the most common chromosome alterations. b) Monosomy 8 and trisomy 7 appeared to be in the same cytogenetic tumoral progression pathway. CONCLUSION: Although we report about a preliminary study, monosomy of chromosome 8 and trisomy 7 are related with poor evolution, probably because of the loss of a suppressor gene or a proto-oncogen overexpression. The presence of any of them in a prostate cancer focus is related with poor prognosis. PMID- 9949570 TI - [Urologic neoplasms in patients with renal transplantation. Experience and review of the literature]. AB - The presence of neoplasms in patients with renal transplant in a higher frequency than in general people is known since a long time. The most frequent tumours were the skin tumours, followed by other tumours common in immunosuppressed patients. The ain of this work has been study the frequency, type, diagnosis, treatment and evolution of the urinary system tumours in patients with renal transplant and an exhaustive review of literature. We have found 11 tumours of the urinary system over 57 tumours in 41 patients, with a frequency 26.8%. 6 were kidney tumours, 3 of prostate and 3 of the bladder. We have analyzed the incidence, diagnosis, treatment and evolution of tumour and its effects on the graft. We believe that the posttransplant follow-up of the patient, overcoat in males, who have tumours in more frequency, is important for the early diagnosis. PMID- 9949571 TI - [Studer's type ileal neobladder. Study of complications and continence]. AB - Analysis of early and late post-surgical complications in 44 cases of Studer's type bladder replacement due to carcinoma of the bladder performed over a 6-year period. Follow-up ranges between 6 months and 6 years. 4 patients died during the post-operative (9.09%): 1 myocardial infarction, 1 pulmonary embolism and 2 intestinal fistula. 28 patients (63.64%) had post-operative complications: 4 GI fistula (9.09%) 5 ileus (11.36%), 2 GI bleeding (4.54%), 1 ureteral fistula (2.27%), 1 ureteral stenosis, 6 urethro-intestinal fistula (13.36%), 1 tubular necrosis, 1 ruptured ureteral catheter, 5 wound infections (11.36%), 12 urine infections (27.27%), 6 sepsis (13.63%), 1 lymphocele, 1 evisceration and 2 eventrations. Repeat surgery was required in 6 cases. Within 6 months from discharge, 7 of 40 patients (17.5%) had some complication: 3 acute pyelonephritis, 4 episodes of acidosis-dehydration and 1 ureter stenosis. After 6 months, 7 of 38 patients (18.4%) had complications: 1 acidosis, 3 vesical lithiasis, 2 ureteral stenosis and 1 urethro-intestinal, plus 2 cases of chronic urinary retention. Daytime continence was 97.2% and nighttime continence 30%; after 6 months evolution, no further changes were seen. PMID- 9949572 TI - [Effect of finasteride on the percentage of free PSA: implications in the early diagnosis of prostatic cancer]. AB - OBJECTIVE: To analyze the behaviour of free PSA percentage in finasteride-treated patients and to evaluate whether this ratio allows an increased PSA specificity in the early diagnosis of prostate cancer. MATERIAL AND METHODS: Evaluation of PSA serum levels and free PSA ratio in 336 patients initially diagnosed with prostate benign hyperplasia (PBH). A group of 82 patients were treated with finasteride for 14 to 58 months. A second group of 254 patients received no treatment. All patients were within the same age range and had similar PSA serum levels. In total, 141 prostate biopsies were performed: 19.5 (16/82) and 49.1 (125/254) respectively. RESULTS: Median PSA level in PBH patients was 1.6 ng/mL for the finasteride-treated group and 3.5 for the untreated group, p < 0.0001. Free PSA ratio was 18.6 and 18.8%, respectively, p > 0.05. Carcinoma detection rate was 25% (4/16) for the finasteride group and 27.2% (34/125) for the untreated group. If biopsy had been requested when PSA percentage was below 25%, 17.7 and 19.8% respectively would have been prevented and all carcinoma detected. CONCLUSION: Long-term treatment with finasteride reduces PSA serum concentration about 50% without changing the free PSA ratio. Carcinoma detection rate was similar in finasteride-treated and untreated patients. Free PSA ratio allows to increase PSA specificity and avoid unnecessary biopsied also in finasteride treated patients. PMID- 9949573 TI - [Post-transplantation renal rupture]. AB - INTRODUCTION: Renal allograft rupture in the transplanted patient represents a usually early postoperatory complication threatening graft and patient survival. Urgent management is often required. MATERIAL AND METHODS: Renal transplanted patients which had rupture of the renal allograft have been reviewed retrospectively. Between February 1980 and June 1996 a total of 868 renal transplants were performed, and 21 (2.41%) suffered from allograft rupture. Diagnosis was based mainly on the symptoms, blood analysis to test hematocrit value, and ultrasounds. RESULTS: Men age of the patients was 34 years old (21 49), 15 (71.4%) males and 6 (28.6%) females. Evolution was as follow: 4 patients underwent extracapsular nephrectomy due to non-functioning kidney; in 16 patients the graft could be preserved using different methods of renal corsetage (lyophilized human dura was applied in 8 cases, fascia lata in one, fascia lata and lyophilized human dura in 3 cases, and polyglycolic acid mesh in other 4 patients); and finally one patient was managed conservatively. There was no intra and post-operatory mortality. Four patients died lately of other causes not related to renal transplantation. Other 4 patients underwent chronic rejection and fail of the renal function. Two of these four patients have already received their second graft. A total of 13 patients have a good renal function (61.9%). CONCLUSIONS: Early diagnosis of the renal allograft rupture must be the main objective in order to initiate as soon as possible therapeutic measures that firstly should be aimed to preserve the graft (medically or surgically). Nephrectomy must be reserved for renal allograft rupture secondary to venous thrombosis and other situations threatening life. PMID- 9949574 TI - [Usefulness of posterior capsulectomy in the treatment of bladder neck disease]. AB - RATIONALE: Presentation of 12-year experience accrued in the surgical treatment of the acquired bladder neck disease. Based on Riches' experience (1961), posterior capsulotomy, although exceptional in terms of indication, was effective in the treatment of 26 patients with early failure of standard endoscopic techniques. MATERIALS AND METHOD: Over a 12-year period, 945 prostatectomies were entered in a protocol, 305 (32.2%) open surgery and 640 (67.8%) transurethral resections. Incidence of sclerosis was 5.03% (48 patients). Treatment of second group with TUR and/or cervicotomy failed in 26 (45-58%) patients. Posterior capsulotomy was effective in 100% patients. RESULTS: Mean follow-up has been productive, and exceeds 4 years based on clinical, radiologic, endoscopic and urodynamic parameters. PMID- 9949575 TI - [Albuginea plication in the treatment of penile curvature]. AB - Presentation of the results obtained by our team in the treatment of 22 cases of penial incurvation (11 congenital and 11 secondary to Peyronie's Disease) using the albuginea plication technique. Evaluation of post-operative results taking into account both subjective (extent of satisfaction, comfort during the post operative etc.) and objective (post-operative complications, degree of correction, reincurvation or failure etc.) factors was done by a follow-up programme through the out-patients practices using a Questionnaire-Survey system. Presentation of results obtained and detailed discussion of each case. The conclusions were as follows: Albuginea plication is a safe technique that achieves total penis redressment, with no post-operative complications. The extent of satisfaction and success obtained exceed 85%, and can be increased by improving the pre-operative selection and providing correct and precise information on what can be resolved with this technique. PMID- 9949576 TI - [Renal carcinoma revealed by sternal metastasis and posterior contralateral adrenal metastasis]. AB - We report a exceptional case of renal cell carcinoma whose first manifestation was bone metastases located in the sternum. Three years after radical nephrectomy solitary contralateral adrenal metastasis appeared. Exeresis bone metastasis, radical nephrectomy and adrenalectomy were performed. The patient is alive with no evidence of disease with hormonal substitute treatment 5 years and 2 months after esternal metastasis exeresis and 1 year and 3 months after right adrenalectomy. PMID- 9949577 TI - [Renal leiomyosarcoma]. AB - Presentation of one case of renal leiomyosarcoma, a tumour with little incidence, focusing the interest of this paper in the treatment and follow-up carried out. Incidence of this type of tumour in the kidneys is scarce, but even more so the number of patients treated with post-nephrectomy chemotherapy. It is therefore unsuitable to draw any conclusions from the review of available publications. However, we believe to have obtained a good result in this case treated with nephrectomy and chemotherapy. PMID- 9949578 TI - [Bone metaplasia of the bladder associated with urothelial tumor. A clinical case]. AB - One case report of bone metaplasia of the bladder wall associated to urothelial tumour located on the urothelium coating the lesion. Suspicion diagnosis started from findings identified in the transurethral resection. A stone-like mass attached by a pedicle to the bladder wall was found during the examination. The pathoanatomical study confirmed the diagnosis of bone metaplasia of the bladder wall, identifying nests of urothelial tumour adjacent to the urothelium. No report of similar cases has been found in the literature referring to the association of urothelial tumour and bone metaplasia of the bladder wall. PMID- 9949579 TI - [Mucinous adenocarcinoma. Unusual prostatic tumor]. AB - We report a case of mucinous adenocarcinoma of the prostate. A 80 years-old patient was diagnosed with a transrectal multiple biopsy. We comment on the special histological patterns of the tumor as well as the established criterion for an appropriate diagnosis. PMID- 9949580 TI - [Adrenal gland myelolipoma. Report of a new case]. AB - OBJECTIVE: We report a new case of symptomatic myelolipoma of the adrenal gland. We analyse clinical, diagnostic, histopathologic and therapeutic aspects. METHOD AND RESULTS: Surgical excision was performed by lumbotomy. The patient was asymptomatic after surgery. DISCUSSION: Adrenal myelolipoma is norfunctioning benign tumour constituted by fat tissue and small islands of haemathopoyetic in a variable rate. The patients are usually asymptomatic. In symptomatic patients the most common symptoms are nonspecific abdominal pain, haematuria and hypertension. The diagnosis is achieved by ultrasound, CT and PAFF. The management is controversial: Surgical treatment or watching are options depending on the size and/or symptoms. PMID- 9949581 TI - [Parameatal cysts of the penis]. AB - Parameatal cysts of the penis are highly infrequent, benign cysts of varied sizes usually unilateral. Contribution of two cases of parameatal cysts of the penis, one and epidermoid inclusion, allegedly post hypospadias surgery, while the other one is similar to the middle raphe cysts and appears to derive from the endodermal debris following a defective closure of the urogenital folds. Treatment is by surgical excision; simple aspiration or marsupialization may result in relapse and unsatisfactory cosmetic results. PMID- 9949582 TI - [Recent advances in the treatment of laryngitis]. PMID- 9949583 TI - [Recommendations for the management of lactose intolerance]. PMID- 9949584 TI - [Prevention and therapy of bronchiolitis: current status]. PMID- 9949585 TI - [Reduction in the number of hospitalizations for asthma. Quality assurance program for the management of asthma crises in a district hospital]. AB - OBJECTIVE: The purpose of this study was to analyze the impact of a quality assurance program intended to improve the care of children with acute asthma in the emergency ward of a first level hospital. PATIENTS AND METHODS: New guidelines for acute asthma management in children were developed and applied beginning 1-1-1997. The ways to deal with an asthma crisis in 1996 and 1997 were compared. The quality guarantee cycle was the method for application of the guidelines, health workers being aware of the starting point (1996) and which areas could be improved. The quality of the clinical assessment of the asthma crisis, the adequacy of treatment, and the final destination of the patients (discharge or admission) were evaluated. RESULTS: Seventy-seven and 68 asthma crises were attended to during 1996 and 1997, respectively. We noticed significant improvements in the clinical assessment of the crisis (p < 0.001), in the correct usage of the term "asthma crisis" (p < 0.001) and in the description of the crisis severity (p < 0.001). The number of improper therapeutic procedures was reduced (p < 0.0001). Children with a mild crisis, except for those associated with risk factors (14% in 1996 and 6% in 1997), were discharged from the hospital. All children with severe crises were admitted to the hospital. Of the children with moderate crises, 75% need hospitalization in 1996, while only 45.1% did during 1997 (p = 0.05). CONCLUSIONS: Following appropriate guidelines during acute asthma attacks implies better care of the asthmatic child and reduces the number of hospital admissions. The quality guarantee cycle is a proper way to achieve these goals. PMID- 9949586 TI - [Ambulatory monitoring of arterial pressure in a group of children with reflux nephropathy of different degrees]. AB - OBJECTIVE: The purpose of this study was to search for risk factors for the evolution reflux nephropathy by comparing the results of the ambulatory blood pressures in a group of children with reflux nephropathy of different degrees. PATIENTS AND METHODS: Out-patient blood pressure monitoring was performed in 31 children (15 males and 15 females) affected to different degrees by reflux nephropathy. This was done during a 24-hour period on a normal schoolday by using a Spacelabs 90207 oscilometric monitor. An appropriately sized armband was chosen for each case with the readings being programmed for every 20 minutes between 8:00 a.m. and 23:00 p.m. and every 30 minutes for the remaining readings. The mean blood pressure, blood pressure load and hyperbaric index over the 24 hour period (on all the readings obtained), activity period (0800 to 2200 hours) and the resting period (midnight to 6:00 a.m.) were calculated. The circadian variability (difference and ratio between the mean values of active and resting periods and the nocturnal fall in blood pressure as a percentage of the daytime mean value) was also determined. The children were classified into subgroups according to their degree of reflux nephropathy: Group 1) Degrees A and B of unilateral reflux nephropathy. Group 2) Degrees C and D of unilateral reflux nephropathy and Group 3) Bilateral nephropathy. Those monitorings with a percentage of erroneous readings over 30% were excluded. RESULTS: Two children were excluded because of a high percentage of erroneous readings. We could not find any significant difference among the three groups in casual blood pressure. We observed significant differences between the group formed by children with unilateral reflux nephropathy and children with bilateral reflux nephropathy in the blood pressure during the resting period. No significant differences were found among the three groups in the tensional load, hyperbaric index or the variables that determine the nightly descent in blood pressure. CONCLUSIONS: Ambulatory blood pressure monitoring allow the detection of risk factors for the evolution of reflux nephropathy; i.e., higher risk of blood pressure elevation, especially during the resting period and mainly for bilateral reflux nephropathy. PMID- 9949587 TI - [Comparative study of bone mineralization in children and adolescents with familial short stature and a control group]. AB - OBJECTIVE: Our objective was to study children with familial short stature (FSS) to observe whether they develop bone mineralization similar to that seen in healthy children with an adequate height for their age and sex. PATIENTS AND METHODS: The study included 70 FSS patients (39 boys and 31 girls) between 6 and 20 years of age and 246 control patients with the same mean age and sex of the study group. Bone mineral density was measured in the lumbar spine and forearm by performing dual energy X-ray absorptiometry using a Hologic ADR-1000. RESULTS: The main difference between the FSS population and the control group was in the final adult bone mass, which was 20% less in the lumbar spine and 15% less in the forearm in the FSS group. CONCLUSIONS: A large difference in bone mineralization was observed among the FSS population compared to the control group during infancy and adolescence and this becomes accentuated with age or growth resulting in bone mineralization that is not optimum for facing the losses which occur during adulthood. PMID- 9949588 TI - [Recurrent epistaxis in children as an indicator of hemostatic disorders]. AB - OBJECTIVE: To distinguish which nosebleeds in children hide an underlying coagulation disorder, characteristics of recurrent epistaxis were evaluated correlating the severity with a battery of specific tests on primary and secondary hemostasis. PATIENTS AND METHODS: Epistaxis of fifty-eight children were classified as mild or severe according to frequency, duration, amount of blood lost, proportion of life that nosebleeds have been recurrent and uni- or bilateral bleeding. Epidemiological characteristics were evaluated, as well as hemostatic tests including: platelet count, mean platelet volume, plasmatic fibrinogen level, prothrombine time, activated partial thromboplastin time, thrombin time, bleeding time, von Willebrand factor antigen and ristocetin cofactor, factor VIII coagulant, and platelet aggregation to different agents. The effect of drugs or the presence of tumors was discarded. RESULTS: In the group of children with mild epistaxis (n = 39) there were three cases with laboratory abnormalities (10.3%). In severe epistaxis (n = 19) abnormalities were found in eleven cases (57.9%) and specific entities were detected in six of them (three children with von Willebrand's disease, one Bernard-Soulier syndrome, one autoimmune thrombocytopenic purpura and one Rendu-Osler-Weber disease). Epistaxis labeled as mild needed less cauterizations and packings, were more related to seasonal prevalence and self-handling, and poorly influenced iron metabolism. CONCLUSIONS: The five qualities pointed out on recurrent epistaxis in children allow the identification of who must be thoroughly studied by means of specific tests to rule out any kind of hemostatic disorder. PMID- 9949589 TI - [Septic osteoarthritis in children]. AB - OBJECTIVE: Our objectives were to assess the clinical and microbiological aspects of septic osteoarthritis in children admitted to our center from 1987 until July 1997 and to determine the sensitivity of ultrasound in this age group. PATIENTS AND METHODS: The medical records of 36 children diagnosed as having septic osteoarthritis of the hip were reviewed retrospectively. The diagnosis had been based on clinical criteria, along with synovectomy and drainage of purulent material from the affected joint. An X-ray and/or ultrasound had been performed when the diagnosis was suspected. RESULTS: Nineteen children were diagnosed during the neonatal period, 8 between the ages of 1 and 12 months and 9 older than one year of age. Mean age at diagnosis was 16.8 +/- 6.2 months (median 29 days, range 6 days to 13 years). The hip was involved in 32 children, the ankle in 3 and the elbow in 1. A microbiological diagnosis was achieved in 22 cases (61%) by culture from blood, CSF, and/or synovial fluid. The most common isolates were Gram positive cocci (S. aureus in 9 cases and coagulase negative Staphylococcus in 3). The diagnostic value of the X-rays was very low (18%). The ultrasound was initially considered abnormal in 64.5% of the patients, with a lower sensitivity in the neonatal period. After a mean follow-up period of 36 months, the outcome was good in 86% of the cases, although three children continue with sequelae. Two preterm infants died due to sepsis associated with the osteoarthritis. CONCLUSIONS: At the time of diagnosis of septic arthritis of the hip, the ultrasound is frequently normal. Due to the poor outcome when there is a delay in surgery, we suggest immediate synovectomy and drainage when there is clinical suspicion of septic arthritis despite an apparently normal ultrasound. PMID- 9949590 TI - [Effectiveness of brain imaging in children with headache]. AB - OBJECTIVE: Headache is a common complaint in children and brain imaging has become widely used to evaluate this clinical condition. We studied the value of neuroimaging in children with chronic headaches. PATIENTS AND METHODS: A retrospective chart review was conducted of all children referred to the pediatric outpatient clinic for evaluation of headache over a 3-year period. The charts were reviewed for headache characteristics, clinical indications for performing neuroimaging, and imaging results. Special attention was paid to evidence of space-occupying lesions. RESULTS: A total of 160 records were studied, with subjects ranging in age from 4 to 14 years. Most patients were diagnosed as having migraine headaches (60%) or chronic tension headaches (29.5%). Other diagnoses were post-traumatic (6%) and unclassified (4%). Sixty six patients (41%) had computed tomography imaging performed. In most cases, brain imaging studies were performed because of clinical data (41%) like atypical pattern, sleep-related headache or increase of headache, because of the parents' concerns about brain lesions (38%) and because of an age less than 5 years (14%). Structural changes were found on brain imaging in 4 patients, but none indicated the presence of a treatable space-occupying lesion and all were deemed unrelated to the headache. Our findings of no relevant abnormalities in a series of 66 neuroimaging studies indicate that the maximal rate at which such abnormalities might appear in this population is 4.4%. CONCLUSIONS: These results indicate that neuroimaging studies have very limited value in the clinical evaluation of pediatric patients with chronic headache and should be reserved for those patients with clinical evidence suggestive of underlying structural lesion. PMID- 9949591 TI - [Ovarian tumors in childhood: apropos of a review of cases]. AB - OBJECTIVE: Our objective was to evaluate the incidence and behavior of ovarian tumors in our population. PATIENTS AND METHODS: Between 1984 and 1994, all clinical charts with the diagnosis of ovarian tumors were reviewed retrospectively. Of 158 tumors in females below 14 years of age, 7 were located in the ovary (4.4%). Clinical presentation, diagnostic methods, histology, treatment and survival were evaluated. RESULTS: The mean age of the patients was 11.3 years (range: 7 months-13.5 years). One child was asymptomatic, 4 complained of abdominal pain, 3 with vomiting and 3 with urinary symptoms. Palpable abdominal masses were found in all, with abdominal distension in 2, ascytes, general malaise and precocious puberty each in one case. Alpha-fetoprotein was elevated in 3 cases and CA 125 in 1. Image studies revealed pleural effusion in one X-ray abdominal mass in 6 abdominal X-rays, which was confirmed by echography in all girls. Histology revealed benign teratoma (3), endodermal sinus tumor (1), malignant teratoma (1), granulosa cell tumor (1) and mixed teratoma and dysgerminoma (1). Treatment consisted in surgical resection (7), total in 5 cases (stage I) and subtotal in 2 (one malignant teratoma and one TSE, stages III). Chemotherapy was added initially in 2 stage III tumors and after relapse in 3. Radiotherapy was not given. Six girls survived. CONCLUSIONS: We comment on the low incidence of these tumors, which can be well diagnosed by using echography. Mixed histology may be misdiagnosed. Chemotherapy may rescue the worse prognostic cases. PMID- 9949593 TI - [Localized scleroderma: lesion "en coup de sabre". Review of the literature and report of a case]. PMID- 9949592 TI - ["Kangaroo method" in the care of premature infants admitted to a neonatal intensive care unit]. AB - OBJECTIVE: More and progressively smaller preterm infants are taken out of the incubator and placed skin-to-skin (kangaroo care) on their mother's chest to promote bonding and breastfeeding. The aim of our study was to know the tolerance to kangaroo care and its security for preterm infants and their mothers, as well as its relationship to breastfeeding. PATIENTS AND METHODS: We studied 445 sessions of 38 stable preterm newborns in our Neonatal Intensive Care Unit (NICU). Their mean birth weight was 1,452 +/- 415 g and gestational age 31.5 +/- 2 weeks (mean +/- SD). The preterm infants, dressed in a diaper and cotton cap, were placed in skin-to-skin contact between their mother's breasts in an upright position and covered with a towel. The kangaroo care duration, temperature, heart rate, respiratory rate, StcO2, and the mother and infant behavioral responses were recorded. During kangaroo care, the preterm infants were nourished by their mother's milk directly by breastfeeding or by intermittent tube feeding, depending on their sucking reflex. The kangaroo care lasted 30-90 minutes, one to eight times a day depending on the availability of the mother. RESULTS: During the kangaroo care, body temperatures, heart rate, respiratory rate and StcO2 remained stable. In the majority of cases, In the majority of cases, the preterm infants showed conduct patterns that indicated good tolerance toward this method, including open hand, sleeping, alert tranquility and even smiles. The breastfeeding sessions were longer than normal because the premature infants alternated short periods of sucking with longer sleep periods. Mothers participated actively looking, talking, touching, smiling and even playing with their preterm infants. CONCLUSIONS: Kangaroo care is a safe and well-accepted method for preterm infants admitted to a NICU and their mothers. Intermittent kangaroo care does not allow for breastfeeding by demand, therefore with the smallest preterm infants, we are obligated to supplement feeding with the mother's milk by tube gavage. PMID- 9949594 TI - [Proteus syndrome and encephalo-cranio-cutaneous lipomatosis, are they the same hamartoma? Apropos of a case]. PMID- 9949595 TI - [Retrograde diastolic flow in the distal aortic arch in a newborn infant with transposition of the great vessels]. PMID- 9949596 TI - [A patient with Pearson and Kearns-Sayre syndrome and a common 4.9 Kb deletion of mitochondrial DNA in blood]. PMID- 9949597 TI - [Goltz syndrome: report of a case in a male]. PMID- 9949598 TI - [Gaucher disease:: evaluation of the response to enzymatic therapy. Apropos of a case]. PMID- 9949599 TI - [Acute diarrhea as a leading symptom of ganglioneuroblastoma]. PMID- 9949600 TI - [Pseudo-Bartter syndrome as a complication of an undiagnosed intestinal malrotation]. PMID- 9949601 TI - [What is your diagnosis? Fever, cough and mediastinal mass (benign thymic hyperplasia)]. PMID- 9949602 TI - [Epidemiology and scientific methodology applied to Pediatrics II: designs in epidemiologic experimentation]. PMID- 9949603 TI - [Continuous treatment with G-CSF in a case of infantile congenital neutropenia]. PMID- 9949604 TI - [Amplification of the clinical spectrum of Robinow syndrome]. PMID- 9949605 TI - [Pica as a form of presentation of celiac disease]. PMID- 9949606 TI - [Growth hormone therapy in short bowel syndrome]. PMID- 9949608 TI - Gatekeepers need education. PMID- 9949607 TI - [Prenatal diagnosis and follow-up of a simple renal cyst]. PMID- 9949609 TI - Misleading advertisement. PMID- 9949610 TI - More on old grades. PMID- 9949611 TI - An ASHA dues increase--a proposal. PMID- 9949612 TI - Is hypernasality a voice disorder? PMID- 9949614 TI - Exploring the damaged ear. The NIDCD National Temporal Bone Registry. PMID- 9949615 TI - Aging & medications. An overview. PMID- 9949616 TI - Rural service delivery: unique challenges, creative solutions. PMID- 9949617 TI - Normal communication changes in older adults. PMID- 9949619 TI - Recent increases in influenza and other respiratory infections. PMID- 9949620 TI - The state of the journal: 1998 achievements and future objectives. PMID- 9949621 TI - Regulation of the proliferative potential of cord blood long-term culture initiating cells (LTC-IC) by different stromal cell lines: implications for LTC IC measurement. AB - BACKGROUND AND OBJECTIVE: Long-term culture-initiating cells (LTC-IC) are the best available approximation to an in vitro assay of stem cells in humans although they still represent a heterogeneous population in terms of proliferative capacity and sensitivity to different growth factors. Human umbilical cord blood (CB) is rich in hemopoietic progenitor cells, as measured by clonogenic assays and contains stem cells capable of reconstituting the marrow after ablation in clinical transplantation. We evaluated the influence of culture conditions on the in vitro behavior of LTC-IC from CB. DESIGN AND METHODS: LTC-IC were evaluated in long-term cultures, comparing two types of murine stromal cell lines: M2-10B4 and M2-10B4 transfected with cDNAs for human G-CSF and IL-3. RESULTS: Two and five fold higher numbers of terminally differentiated cells were produced during nine weeks of culture of CB mononuclear or CD34+ cells respectively, in cultures containing a M2-10B4 IL-3 G-CSF cell line compared to cultures containing the parental cell line. Likewise, a higher number of colony forming cells (CFC) were detected in the supernatant of cultures with the transfected cell line. In contrast, the number of CFC generated within the stromal layer, after 5 or 9 weeks of culture, was significantly higher in cultures on M2-10B4 cells than those on M2-10B4 IL-3 G-CSF. INTERPRETATION AND CONCLUSIONS: Our results show that the proliferative capacity of CB LTC-IC can be strongly influenced by culture conditions and that the frequency of LTC-IC estimated using these cell lines as stromal support is not identical. PMID- 9949622 TI - High incidence of the CD8/9 (+G) beta 0-thalassemia mutation in Spain. AB - BACKGROUND AND OBJECTIVE: In Spain, as in other Mediterranean regions the most common beta-thalassemia mutations are due to point mutations in gene regions that are critical for production of mRNA, such as [IVS-I-nt1 (G-->A), IVS-I-nt6 (T- >C), IVS-I-nt110 (G-->A)] which interrupt normal RNA processing or nonsense mutations [CD39 (C-->T)] which interrupt the translation of mRNA. The frameshift mutation CD8/9 (+G) is a very common allele in Asian Indians but is rare in the Mediterranean regions in which isolated alleles with this mutation have been found in Israel, Greece, Portugal and Turkey. DESIGN AND METHODS: We performed a molecular analysis of 175 chromosomes corresponding to 233 beta-thalassemia patients (221 heterozygous, 10 homozygous and 2 compound heterozygous) who belong to 169 Spanish families. The study of beta-thalassemia was made by PCR-ARMS, the alpha genes by Southern blot, the phenotype of Hb Lepore by enzymatic amplification and the presence of -158 gamma G C-->T mutation by PCR and digestion with the restriction enzyme XmnL. RESULTS: Twenty of these 233 patients showed the beta-thalassemia mutation CD8/9 (+G) (17 were heterozygous, 2 homozygous and in one patient the mutation was associated with a structural variant Hb Lepore Boston). INTERPRETATION AND CONCLUSIONS: These data reveal the heterogeneity of beta-thalassemia in Spain and the relatively high frequency (8.6%) of the frameshift mutation CD8/9 (+G). It is surprising that homozygotes for beta zero-thalassemia due to this mutation with very high Hb F values (around 90%) present a phenotype of intermediate thalassemia. PMID- 9949623 TI - Immunophenotypic analysis of CD19+ precursors in normal human adult bone marrow: implications for minimal residual disease detection. AB - BACKGROUND AND OBJECTIVE: Normal B-cell differentiation has been characterized extensively, but discrepancies persist regarding the exact sequence of antigen expression. Few systematic studies focusing on identification of the minor or undetectable B-cell subsets in normal human bone marrow (BM) which are frequently found in leukemic cells have been performed. Such studies could help to monitor minimal residual disease (MRD) in precursor-B-acute lymphoblastic leukemia (precursor-B-ALL). The aim of the present study was to analyze the sequence of antigen expression among normal human CD19+ B cells from adult BM. Our major goal was to identify infrequent and undetectable B-cell phenotypes that could be used for the detection of MRD in patients with precursor-B-ALL. DESIGN AND METHODS: Adult BM samples from a total of 33 healthy volunteers were analyzed using triple stainings, and measured by flow cytometry. A sensitive method based on the two step acquisition procedure was used for the identification and characterization of cells present at very low frequencies. RESULTS: Five different subsets of CD19+ cells were identified in normal BM samples according to their degree of maturation: 1) CD19+/CD34+/CD10-/CD20-/CD22dlm+ (0.5 +/- 0.4% B cells); 2) CD19+/CD34-/CD10++/CD20-/CD22dlm+ (3.4 +/- 2.7%); 3) CD19+/CD34-/CD10+/CD20 /CD22dlm+ (3.5 +/- 2.2%); 4) CD19+/CD34-/CD10+/CD20+,++/CD22dlm+ (21 +/- 11%), and 5) CD19+/CD34-/CD10-/CD20++/CD22+ (73 +/- 19%). We observed that several B cell phenotypes are frequent among precursor-B-ALL, but are infrequent or undetectable in normal human B cell differentiation. Accordingly, in all normal BM samples analyzed, less than 4 x 10(-5) cells co-expressed CD19 and CD117; CD20strong+/CD34+ and CD22strong+/CD34+ events were found at frequencies less than 5 x 10(-4), while CD20+/CD34+ phenotypes were found in less than 1 x 10(-3) BM cells. Although both CD19+/CD13+ and CD19+/CD33+ events were found at frequencies of up to 3 x 10(-3), they never formed a well-defined population of cells and therefore these latter phenotypic patterns could also be of use for MRD investigation in CD13+ and/or CD33+ precursor-B-ALL cases. INTERPRETATION AND CONCLUSIONS: Our results show that in adult BM normal B-cells display constant patterns of maturation as regards both their phenotypic characteristics and their relative distribution. Abnormalities in these patterns provide a potentially useful tool for monitoring MRD in precursor-B-ALL patients who achieve cytomorphologic complete remission. PMID- 9949624 TI - Influence of marrow erythropoietic activity on serum erythropoietin levels after autologous hematopoietic stem cell transplantation. AB - BACKGROUND AND OBJECTIVE: Serum erythropoietin (sEpo) concentration depends primarily on the rate of renal production in response to hypoxia. However, sEpo levels increase inappropriately after conditioning for autologous stem cell transplantation (ASCT) before progressively returning to adequate levels. We investigated the possible influence of erythropoietic activity on these observations. DESIGN AND METHODS: Forty patients undergoing an ASCT, 8 with bone marrow (BMT) and 32 with peripheral blood stem cells (PBSC), were separated into 3 groups. Group 1 was formed of the 8 BMT patients (median time to 1% reticulocytes: 39 days), group 2 of 16 PBSC patients with relatively slow erythroid engraftment (> or = 15 days to 1% reticulocytes, median 19 days) and group 3 of 16 PBSC patients with prompt erythroid recovery (< 15 days to 1% reticulocytes, median 13 days). Marrow erythroid activity was assessed by serum transferrin receptor levels (sTfR). Serum Epo (sEpo) levels were expressed in relation to the degree of anemia as observed/predicted (O/P) ratios of (O/P) log (sEpo). RESULTS: Serum sTfR levels decreased by more than 50% in all 3 groups after conditioning, reaching their nadir on day 7. Nadir values doubled by day 28 in group 3, day 60 in group 2, but not within 100 days in group 1. O/P sEpo ratios increased inappropriately in all 3 groups after conditioning but then declined at very differing speeds in the 3 groups. In group 1, ratios remained above 1.10 through to day 28 and above 1.00 through to day 42, before leveling off at around 1.00 thereafter. In group 2, ratios remained above 1.00 through to day 14, than decreased to a minimum of 0.89 by day 42 before returning to 1.00 by day 100. In group 3, ratios decreased to 0.84 by day 21 and remained below 0.90 thereafter. INTERPRETATION AND CONCLUSIONS: We conclude that sEpo levels are not only influenced by tissue oxygenation but also depend on the mass of erythroid precursors in the bone marrow. This may be the main explanation for the observed changes in sEpo levels during ASCT. PMID- 9949625 TI - IL-6 and IL-8 levels in plasma during hematopoietic progenitor transplantation. AB - BACKGROUND AND OBJECTIVE: The relationship between cytokine concentrations and transplant-related complications has been studied in bone marrow transplant patients. The changes in TNF-alpha, IL-1 and IL-6 concentrations after transplantation are well documented in the literature but this is not the case for IL-8. The purpose of the present study was to investigate prospectively the plasma concentration of these cytokines and their relationship to transplant related complications. DESIGN AND METHODS: Pro-inflammatory cytokine (TNF-alpha, IL-1, IL-6 and IL-8) levels in plasma were determined in a group of 53 patients undergoing hematopoietic progenitor transplantation. Plasma samples were collected weekly from day -7 to day +35 and stored at -70 degrees C until assayed by ELISA. The major transplant-related toxicities registered were: veno-occlusive disease (VOD), acute graft-versus-host disease (GVHD), infectious episodes, renal failure and mucositis. RESULTS: In spite of the great variability of plasma cytokine profiles between the different patients, we came to various conclusions. Patients' TNF-alpha and IL-1 concentrations correlated well over time. IL-6 and IL-8 profiles were similar and correlated well with febrile episodes. In some cases, an increase in IL-6 preceded hematologic recovery. In our study, increased levels of TNF-alpha, IL-6 and especially IL-8 correlated with hepatic or renal dysfunction as evaluated by increased bilirubin and creatinine in plasma, while pulmonary complications correlated only with increased IL-6 levels. Allogeneic transplant patients had a tendency to have higher TNF-alpha concentrations than autologous transplant patients, probably because an allogeneic transplant is associated with more transplant-related toxicity. Basal disease usually had no effect on cytokine profiles. INTERPRETATION AND CONCLUSIONS: IL-6 and IL-8 were the only cytokines studied whose increase correlated with febrile episodes. High IL-8 values may be a useful predictor of renal dysfunction and pulmonary disease and seems to trigger off high IL-6 levels. Plasma TNF-alpha and IL-1 concentrations during the posttransplant period have not been shown to be predictive of the development of transplant-related complications, and none of the profiles was recognized to be specific for a particular complication in this study. PMID- 9949626 TI - Functional and clinical relevance of CD44 variant isoform expression on B-cell chronic lymphocytic leukemia cells. AB - BACKGROUND AND OBJECTIVE: Recent studies have shown that expression of adhesion molecules of the Ig superfamily, of integrins and of selectins allows definition of high vs low risk B-cell chronic lymphocytic leukemia (B-CLL). The proteoglycan CD44 is an adhesion molecule that may be expressed as a standard form of 85-95 KD or as several variant isoforms. The presence of certain CD44 variant (v) isoforms on neoplastic cells indicates poor prognosis in epithelial and lymphoid malignancies, as it is associated with tumor progression and metastasis. DESIGN AND METHODS: The expression of CD44 v3, 4, 5, 6, 7, 9 and 10 was analyzed in cells from 85 B-CLL patients. Indirect immunofluorescence and flow cytometry were used to identify CD44v. Functional studies were performed by analysis of adhesion to hyaluronate (HA), one CD44 ligand, and HA-induced Ca2+ influx. A variety of statistical methods were used to define phenotypic and functional differences between the various clones, to calculate survival curves, and for multivariate analyses. RESULTS: In 17/85 B-CLL (20%), one or more CD44v were detectable by indirect immunofluorescence, whereas in 68/85 cases (80%) this technique yielded negative results. However, moAb "mixes" against CD44v and patching of surface molecules on B-CLL cells have shown that all B-CLL clones express CD44v. This has been confirmed by Western blot in a number of cases. Thus, two groups of patients whose cells bear CD44v at high or low density, are distinguished. Functions of the two clonotypes were investigated, namely their adhesion to a CD44 ligand and hyaluronate (HA), and effect on HA-induced Ca2+ influx. Cells expressing high density CD44v adhere to HA-coated substrates more efficiently than cells with low density CD44v. In all clones, HA-signaling via CD44 yields Ca2+ influx. This indicates that CD44 mediates activatory signals following interaction with the ligand. INTERPRETATION AND CONCLUSIONS: The clinical relevance of these findings has been ascertained. The 17/85 cases whose cells bore high density CD44v had significantly worse prognostic features than those of patients with low density CD44v, namely more advanced disease stage, LDT < 12 months and therapy requirement. Moreover, the median survival in the former group of patients was < 5 years as opposed to > 12 years in the latter. Therefore, analysis of CD44v expression provides indications of biological and clinical relevance also in low grade lymphoproliferative disorders. PMID- 9949627 TI - WWW accessible system for national/regional registries of clinical results of cord blood transplants: a tool to facilitate cooperative clinical research. AB - A system, accessible via internet, has been developed to support the Spanish Registry of Cord Blood Transplants (RETSCU). The system includes a database of clinical results directly accessible by transplant centers (TCs) and cord blood banks (CBBs) (restricted to own cases regarding primary data and unrestricted regarding statistics derived from validated data) and gives open access to Web pages containing results approved for publication. It also includes internal mail for two-way and broadcast messages. Patients' data are essentially those included in Eurocord forms. Additional features of the system are: confidentiality; inalterability of validated primary data; identifiability of data sources. The Unix central computer is accessible via the WWW. For security, data transmission is encrypted and passwords are required for access. Copies are regularly updated. Data can be loaded from CBBs and TCs. The procedure for creating and updating records is user-friendly, with the possibility of errors being minimized by extensive automated checks. Validation of patients' records by a manager is required before making data available for general statistical analysis. TCs and CBBs may retrieve data on their own cases, regardless of validation, as individual records or in tables directly transferable to common statistical programs. Statistical analysis may be done on validated data from all the patients in the Registry or from groups selected according to HLA compatibility and disease, type of transplant (related/unrelated), or protocol. Several similarly designed and managed national/regional Registries might be networked and their data integrated into a multinational Registry. Our system would require some additional developments to be used in this way. PMID- 9949628 TI - Surface marker abnormalities in myelodysplastic syndromes. AB - BACKGROUND AND OBJECTIVE: The myelodysplastic syndromes (MDS) are clonal stem cell disorders associated with a variety of abnormalities of mature and maturing cells, including surface antigen abnormalities. Granulocytes and monocytes function as members of the immune system. Surface antigens serve as biological sensors allowing various cells to interact with different stimuli. Abnormalities of surface antigens may be associated with defective cell function and may indicate a more severe or more advanced stage of the disease. INFORMATION SOURCES: The author has a great interest in bone marrow changes in MDS and has several previous publications in this field. In addition, relevant articles published since 1966 were retrieved using Medline of English literature and were included. STATE OF THE ART AND PERSPECTIVES: Several surface antigens in MDS have shown abnormal expression either in the intensity of fluorescence or the percentage of positive cells. These abnormalities include increased, decreased or lineage-aberrant expression. Abnormalities of several surface markers have prognostic significance. MDS patients with a low percentage of bone marrow cells expressing CD11b had a higher risk of evolution to acute myeloid leukemia and shorter survival compared to patients with more than 53% of marrow cells expressing CD11b (29 weeks versus 160 weeks). On the other hand, an increased percentage of bone marrow cells expressing early or immature markers, such as CD 13, CD33, CD34 and HLA-DR, has been associated with a worse outcome and with progression to a higher risk MDS or to acute myeloid leukemia. However, there are numerous discrepancies and inconsistencies in the literature when reviewing surface marker changes in MDS. These discrepancies may be related, at least in part, to the presence of an intracellular storage compartment of numerous surface antigens in the granulocytes and monocytes. Because of these storage pools, the techniques of preparing more mature granulocytes and monocytes, such as density gradient separation, and the interpretation of results must be carefully evaluated. Furthermore, various methods have been used to express abnormal results including percentage of positive or negative cells, fluorescent intensity (FI) of individual patients or a group of patients using a mean fluorescent channel (256 or 1024 channel mode), and finally the expression of FI as molecules of equivalent soluble fluorochromes or antibody binding capacities. Several mechanisms may be involved in the abnormal expression of surface antigens in MDS including defective granulopoiesis, defective intracellular storage pool, abnormal membrane of cytoplasmic granules, and the effect of high levels of marrow cytokines such as tumor necrosis factor alpha and transforming growth factor-beta. Standardization of the methods of preparing and studying mature and maturing granulocytes and monocytes in MDS has to be achieved in order to produce comparable results, thus allowing surface marker studies to be utilized as diagnostic and prognostic tools in MDS. PMID- 9949629 TI - Ocular presentation and successful outcome of invasive sphenoid sinus aspergillosis in acute myelogenous leukemia. AB - We report the case of a 73-year-old male with acute myelogenous leukemia, who progressively developed a cavernous sinus syndrome during the aplastic phase after induction chemotherapy. Although the clinical, serological and radiological findings suggested an invasive sphenoid sinus aspergillosis, endoscopic ethmoido sphenoidectomy allowed definitive diagnosis of the infection. After surgery, fungal eradication and reversal of the neurophtalmological damage paralleled complete hematologic remission. The differential diagnoses of the patient ocular symptoms are discussed. Early recognition, prompt intervention and immunologic reconstitution are essential for successful outcome of paranasal mycoses in immunosuppressed patients. PMID- 9949630 TI - Unusual bone marrow metastases in a breast cancer patient. PMID- 9949631 TI - Increased bcl-2/bax ratio in B-cell chronic lymphocytic leukemia is associated with a progressive pattern of disease. AB - In order to evaluate clinical implications of altered expression of bcl-2 and bax proteins in B-cell chronic lymphocytic leukemia (CLL) we studied 27 patients with this disease. Cytofluorometric levels of bcl-2 did not reflect the status of disease. In contrast bax expression was lower in progressive than in non progressive disease, therefore leading to a higher bcl-2/bax ratio in patients of the former group. If confirmed in longitudinal studies, quantitative cytofluorometric evaluation of bcl-2 and bax protein might help to identify patients with progressive disease who could possibly benefit from early therapy. PMID- 9949632 TI - Reversal of bone marrow fibrosis in idiopathic myelofibrosis after treatment with alpha-interferon. AB - A 14-year-old boy presenting with primary myelofibrosis (MMM) was treated with alpha-interferon (IFN). After 6 months his spleen was no longer palpable and blood counts had returned to normal. A reversal of bone marrow fibrosis was histologically documented. Although improvement in symptoms and blood counts has been reported, this is only the second description of reversal of bone marrow fibrosis in MMM after treatment. PMID- 9949633 TI - Moderate hyperhomocysteinemia is a highly prevalent defect in Spanish patients with venous thromboembolic disease. AB - Recent studies suggest that mild hyperhomocysteinemia may be a risk factor for venous thromboembolic disease (VTED). In this work we evaluated the prevalence of moderate hyperhomocysteinemia in patients with VTED in our area. We found hyperhomocysteinemia in 23.4% of 64 patients studied compared with 7.35% of 68 healthy controls (p = 0.014). Our results suggest that moderate hyperhomocysteinemia is one of the most prevalent abnormalities associated with VTED. PMID- 9949634 TI - Percutaneous umbilical blood sampling in the management of immune thrombocytopenic purpura during pregnancy. AB - Severe neonatal thrombocytopenia occurs in about 15% of deliveries from women with immune thrombocytopenic purpura (ITP). Conflicting data exist about the real usefulness of percutaneous umbilical blood sampling (PUBS) in evaluating the fetal platelet count. We report successful experience, using PUBS, in the management of 12 pregnant women with ITP. PMID- 9949635 TI - Adenovirus pneumonitis successfully treated with intravenous ribavirin. AB - Adenovirus infections are a frequent cause of severe complications in the post allogeneic bone marrow transplantation period, and to date, no established form of treatment exists. We report the case of an autologous bone marrow transplant recipient who developed adenovirus pneumonitis which was successfully treated with intravenous ribavirin. PMID- 9949637 TI - We've been good citizens. PMID- 9949636 TI - Portal and mesenteric venous thrombosis in a patient heterozygous for the 20210 A allele of the prothrombin gene. AB - We give the first description of portal and mesenteric venous thrombosis associated with the 20210 A allele of the prothrombin gene in a 48-year-old woman after splenectomy. PMID- 9949640 TI - HCFA: Y2K is top priority. PMID- 9949639 TI - Time is running out! Are you Y2K compliant? PMID- 9949638 TI - Slicing the Medicaid pie. PMID- 9949641 TI - Medicaid payment for pharmaceutical care? PMID- 9949642 TI - Treating family members? Ethics caution against it. PMID- 9949643 TI - Early retirement? Is it possible? PMID- 9949644 TI - Physician-assisted suicide: reflections on Oregon's first case. AB - The authors analyze Oregon's first reported assisted suicide of Mrs. A as a real life application of the Oregon Death with Dignity Act. They critique the effectiveness of the Act's safeguards as illustrated by the case of Mrs. A. They point out that the Act does not require that physicians be adequately trained in palliative care in order to participate in assisted suicide. Most physicians do not have such training. Without it, they are not able to effectively present alternatives to patients requesting assisted suicide. Most physicians also lack the expertise to assess patients' decision-making capacity. Nor does the Act ensure that physicians will be in a position to assess coercion of patients' decisions. The Act requires physicians to report only minimal information about their cases, and there are no enforcement provisions to see that even this is done. Under the Act, a good faith standard rather than the more usual negligence standard immunizes physicians from civil or criminal liability even when they act negligently. The authors demonstrate that the Act protects physicians more than patients, and encourages secrecy. The authors conclude that secrecy will need to be replaced by openness to permit the kind of examination the practice of assisted suicide warrants. PMID- 9949645 TI - Assisted suicide: a disability perspective. National Council on Disability. PMID- 9949646 TI - Physician-assisted suicide and euthanasia in The Netherlands: a report to the House Judiciary Subcommittee on the Constitution. PMID- 9949647 TI - The Oregon Death with Dignity Act. PMID- 9949648 TI - A model of primary HIV-1 infection. AB - We construct a model based on biological principles of the interaction of HIV-1 with the CD4+ T cells at primary infection. Most of the parameters are obtained from the literature, the remainder from fitting the output of the model to data from seven patients. On the basis of the model we find that initial viral containment is due to an effective immune response. The viral level after the initial peak, a surrogate marker of disease progression, was determined by the rate of reactivation of memory cells. Differences in this rate may occur because of inter- or intra-individual differences in the capability of memory cells to recognise and dispose of variants of HIV, either due to immune escape mutations within the virus or because the virus directly inhibits reactivation. With no choice of parameters could direct and indirect killing produce the gradual loss in CD4+ T cells with the observed viral behaviour. The loss of CD4+ T cells is perhaps due to defective expansion of activated cells of both HIV specific and nonspecific cells. As less memory cells are produced as a result then this compartment decreases and hence so do naive numbers through less reversion of memory cells to the naive phenotype. PMID- 9949649 TI - On the coexistence of three microbial populations competing for two complementary substrates in configurations of interconnected chemostats. AB - We examine the question of coexistence of three microbial populations competing for two complementary rate-limiting substrates in configurations of interconnected chemostats. It is known that coexistence of two populations competing for two rate-limiting substrates is possible in a single chemostat, but coexistence is not possible when three populations are involved. We examine whether coexistence of three populations becomes possible by considering configurations of two or three interconnected chemostats, thus allowing for effects of spatial heterogeneity. Computational analysis of the model equations indicates that in the case of two chemostats coexistence is possible only for specific discrete parameter values where the system is structurally unstable and therefore the coexistence state is not practically attainable, whereas in the case of three chemostats coexistence is possible for a whole range of parameter values where the system is structurally stable and therefore the coexistence state can be realized in practice. PMID- 9949650 TI - A novel algorithm for tracing the interaction of a track with molecular targets- use of Delaunay triangulation. AB - This paper describes an efficient method for tracing interactions between a radiation track and molecular targets in a cell or nucleus. The method is efficient because it ensures that a minimal subset of interactions in the track needs to be tested for each score. It is most useful for high-energy particles since the number of interactions and range of the tracks increase with particle energy. In this method, the set of interactions, i.e. the track, is considered as a collection of points in three-dimensional space. This set, together with the eight vertices of a bounding box, is discretised as a collection of tetrahedra, each of which satisfies the Delaunay criterion. Because of the geometric properties of these tetrahedra, only those points which are connected to vertices of tetrahedra through which the target passes need be tested for scoring. An efficient algorithm is used to follow the track through the cell or the nucleus. The main benefit of the method is that it eliminates the need to test those interactions which are geometrically distant from the target. In particular, in cases where there are no interactions in the target, very few interactions need to be checked. PMID- 9949651 TI - The effect of random vaccine response on the vaccination coverage required to prevent epidemics. AB - The response people have to vaccination varies because their immune systems differ and vaccine failures occur. Here we consider the effect that a random response, independent for each vaccinee, has on the vaccination coverage required to prevent epidemics in a large community. For a community of uniformly mixing individuals an explicit expression is found for the critical vaccination coverage (CVC) and the effect of the vaccine response is determined entirely by the mean E(AB), where A and B, respectively, reflect the infectivity and susceptibility of a vaccinated individual. This result shows that the usual concept of vaccine efficacy, which focuses on the amount of protection the vaccine provides the vaccinee against infection, is not adequate to describe the requirements for preventing epidemics when vaccination affect infectivity. The estimation of E(AB) poses a problem because A and B refer to the vaccine response of the same individual. Similar results are found when there are different types of individual, but now the mean E(AB) may differ between types. However, for a community made up of households it is shown that the CVC also depends on other characteristics of the vaccine response distribution. In practice this means that estimating a single measure of vaccine effectiveness is generally not enough to determine the CVC. For a specific community of households it is found that the vaccination coverage required to prevent epidemics decreases as the variation in the vaccine response increases. PMID- 9949652 TI - Sleepless in New Jersey. PMID- 9949654 TI - Planning for compliance. PMID- 9949653 TI - Pain in the back. PMID- 9949655 TI - Simulating memory. PMID- 9949656 TI - Pain management. The mind matters. PMID- 9949657 TI - Recommendations for occupational exposures to HIV. PMID- 9949658 TI - Ethical dimensions. Medical decisions for EMS. PMID- 9949659 TI - Chronic disseminated infection and intravesical bacillus Calmette-Guerin. PMID- 9949660 TI - Toward hospitals without paper. PMID- 9949661 TI - [Heparin therapy: 1998 (current use of the 80-year-old heparin)]. AB - The 80th anniversary of the best known glycosaminoglycan, a mixture of mucopolysaccharides, named heparin by Howell and Holt in 1918 is celebrated this year. It was widely used during the last six decades in prevention and treatment of venous thromboembolism causing a significant decrease of death from pulmonary embolism and the morbidity of deep venous thrombosis. Conventional, unfractionated heparin is also administered on many other topics. Some more than ten years ago the fractionated, low-molecular-weight heparins were introduced into clinical practice and it seems increasingly likely that the fractionated preparations of this classic drug will take over the dominating role. The present study intends to summarize the today's possibilities of prevention and treatment of thromboembolism mostly on the venous side of circulation. PMID- 9949662 TI - [Polysomnographic screening of infants at risk for SIDS]. AB - The authors present a Sudden Infant Death Syndrome prevention program. The study analyses the data of 92 children having participated in the complex prevention program, including polysomnography, between May 1997 and February 1998. The role of polysomnography and its use as a clinical method is described through the statistical analysis of the results of the study. PMID- 9949663 TI - [Paraneoplastic nephropathy associated with adult renal carcinoma (immunologic and clinicopathologic study)]. AB - Rare "paraneoplastic nephropathies" are associated with a wide variety of human tumors. Little is known about the pathogenetical background. To our knowledge no systematic study about the association of potentially "immunogenic" renal cell cancer (RCC) and "paraneoplastic nephropathy" has been published so far. An immunohistochemical analysis of native kidneys and a nephrological follow up of 60 patients with renal cell cancer (RCC) treated at the Department of Urology, medical University, Pecs (Hungary) between 1993-1998 has been performed. Cellular and humoral immunity was analysed by immunohistochemistry. Clinical/laboratory parameters of the patients with tumor associated nephropathy were pre- and postoperatively registered. Eleven IgA-nephropathy (IgA-NP) and 5 focal segmental glomerulosclerosis (FSGS), manifested in preoperative clinical signs in 11 out of 16 cases were found. Clinical symptoms disappeared in 6 out of 8 IgA-NP patients by tumor nephrectomy in a follow up of 38.7 (18-51) months. Eleven out of 16 tumors were stained with the identical anti human immunoglobulin (IgA or IgM) present in the glomerular immune complexes. The RCC-associated VHL (von Hippel Lindau) protein was detectable in 3 out of 8 IgA-NP patients as an antigen component of their nephritogenic immune complexes. Tumor infiltrating lymphocytes (TIL) considered as a local sign of cellular tumor immunity were more frequently present in tumors associated with nephropathy than without it (69% vs 25%). Pathogenetic correlation between the tumor immunity in renal cell carcinoma and "paraneoplastic IgA-nephropathy" has been demonstrated in some of the cases. Tumor nephrectomy excluding the need of post-operative single kidney biopsies should be a safe tool in the differential diagnosis of tumor-associated nephrological conditions. PMID- 9949665 TI - [Opening of the university medical school in Ghana]. PMID- 9949664 TI - [Additive effect of marihuana and retrovirus in the anergy of natural killer cells in mice]. AB - Among the immunosuppressive effects of marijuana, impairment of natural killer cell activity is significant. HIV also inhibits these cells. Friend leukemia virus complex and its helper component Rowson-Parr virus induce early immunosuppression in mice resembling human AIDS, and late leukemia, providing a small animal AIDS model. Leukemia susceptible BALB/c and resistant C57BL/6 mice were infected with these viruses. At different time points, their natural killer cells separated from spleens were treated with 0 to 10 micrograms/ml tetrahydrocannabinol, subsequently mixed with Yac-1 target cells for 4 and 18 h. The natural killer cell activity in both mouse strains infected by either virus complex or helper virus weakened on days 2 to 4 postinfection, normalized by day 8 and enhanced on days 11 to 14. Natural killer cell activity upon the effect of low concentration (1.0 to 2.5 micrograms/ml) of tetrahydrocannabinol slightly increased in BALB/c, was unaffected in C57BL/6, especially in 18 h assays. In the combined effects of marijuana and retrovirus, damages by marijuana dominated over those of retroviruses. Inhibition or reactive enhancement of natural killer cell activity on the effect of viruses are similar to those of infected but marijuana free counterparts, but on the level of uninfected cells treated with marijuana. The effects of marijuana and retrovirus are additive resulting in anergy of natural killer cells. PMID- 9949666 TI - [Medals of Hungarian gerontology]. PMID- 9949667 TI - Epidemiology and prognosis of Pseudomonas aeruginosa bacteremia in a tertiary care center. AB - OBJECTIVE: To describe the epidemiology and prognosis of P. aeruginosa bloodstream infections in a tertiary-care center. DESIGN: Retrospective analysis. SETTING: Tertiary-care teaching hospital in Mexico City. PATIENTS: All cases of P. aeruginosa bacteremia diagnosed from 1981 to 1994. DATA: Relevant demographic, clinical and therapeutic variables were analyzed. RESULTS: A total of 153 bacteremias were found between 1981 and 1994, with a mean prevalence of 4.1 episodes per 1000 hospital discharges. Twenty-five percent of the infections derived from the biliary tract, and the most frequent underlying diseases were hematologic malignancies. The overall crude mortality was 46% (70/153) whereas mortality in the nosocomially-acquired episodes was 47% (58/124). Mortality within the first 72 h was 24% (37/153). A multivariate analysis showed six risk factors associated with a fatal outcome: age > or = 40 years, shock, mechanical ventilation, prior use of antibiotics, splenectomy and inappropriate selection of antibiotics. CONCLUSION: The identification of risk factors, and therefore a prompt instauration of specific antibiotic therapy, improved the prognosis of these severely ill patients. PMID- 9949668 TI - Effects of metformin on fibrinogen levels in obese patients with type 2 diabetes. AB - OBJECTIVE: To determine fibrinogen levels in obese patients with type 2 diabetes and assess its changes with the use of metformin. METHODS: 60 obese patients (BMI > 27) with type 2 diabetes were studied in an open, two phase, prospective, randomized and comparative study. The pre-treatment phase was a period of four weeks of a controlled diet. In the treatment phase they were divided in two subgroups of 30. One received metformin as a daily single tablet of 850 mg and increasing the dosage to two or three tablets depending on their metabolic control. The second subgroup received 24 units of DNA-recombinant insulin subcutaneously (two thirds of dose before breakfast, and the remaining third before dinner). The insulin dosage was adjusted according to the metabolic response. A control group was formed by 60 non diabetic obese patients with only the controlled diet. RESULTS: The mean values of plasma glucose, fibrinogen levels and body mass index did not change in the pretreatment phase in controls and diabetics. These parameters decreased significantly in the metformin subgroup in the treatment phase (p < 0.001). Only glucose decreased in the insulin subgroup. There were no changes in the controls. CONCLUSIONS: In addition to improving metabolic control, metformin showed to be a good therapeutic alternative in modifying fibrinogen levels in type 2 diabetic patients. PMID- 9949669 TI - Alpha-thalassemia in a selected population of Mexico. AB - OBJECTIVE: To identify by molecular biology the alleles of alpha-Thal in selected hospital populations. METHODS: Eighteen propositi with hematological and biochemical data suggestive of alpha-thalassemia, selected from 356 patients of four hospitals in two cities with probable hemoglobinopathy were investigated for six common alpha-Thal alleles. Molecular studies were done by PCR and digestion with specific restriction enzymes. RESULTS: The alpha 3.7 allele was identified in two cases and the family study revealed the same allele in the mother; HbS heterozigocity was also detected in one of them. An analysis with Apa I demonstrated a class I deletion in both patients. The present study showed 2/356 (0.6%) of alpha 3.71 carriers which is a low frequency as compared with other countries. As no other common alpha-thalassemia alleles were found, we suspect that alpha-Thal in Mexico is as heterogeneous at a molecular level as beta-Thal. PMID- 9949670 TI - [Laparoscopic adrenalectomy in a mexican institution]. AB - AIM: To analyze the general characteristics and outcome of laparoscopic adrenalectomy in our institution. METHODS: The clinical and intraoperative characteristics, complications and outcome of 29 consecutive patients undergoing lateral transperitoneal laparoscopic adrenalectomy between February 1995 and January 1998 were analyzed. RESULTS: Their mean age was 34 +/- 11 years, 6 were males and 23 females. The most common preoperative diagnosis was recurrent Cushing's disease followed by functioning adenomas and pheochromocytomas. There were 17 unilateral and 12 bilateral adrenalectomies. The mean operative time was 2.5 +/- 1 hours for each gland. Two patients were converted to the open technique. There were two complications: a wound infection and a postsurgery hypoglycemia. The hypoglycemic patient also developed massive upper gastrointestinal bleeding 18 days after surgery and died. The mean postoperative hospital stay was 5 days. In a mean follow-up of one year, recurrence of one pheochromocytoma was seen. CONCLUSION: Laparoscopic adrenalectomy was a safe operation that favored early recovery. PMID- 9949671 TI - [Free amino acids in plasma and milk of mexican rural lactating women]. AB - OBJECTIVE: To determine the free amino acid pool in plasma and milk in Mexican rural lactating women. METHODS: Twenty-eight women with an age 24 +/- 5.0 (+/- SD) years, weight 50 +/- 4.9 kg and height 148 +/- 4.8 cm were studied under metabolic balance conditions. Subjects were divided into five groups (three groups of lactation at 1st, 3rd and 6th month, one post-weaning group and a control group of non pregnant, non lactating women). Amino acid analyses of the diet and of plasma and milk samples were performed using an automated amino acid analyzer. RESULTS: Differences were observed between the lactation groups and the other groups: aspartate increased at the 6th month (p < 0.05) while leucine, valine and isoleucine declined in the 3rd month (p < 0.05). In milk, valine, proline and taurine decreased at 6 months (p < 0.05), while serine and threonine raised at 3 months. Plasma levels were > 4 fold greater than milk levels for branched chain amino acids and for the basic, aromatic and neutral amino acids. In contrast, glutamate was 40 fold higher in milk than plasma and it was the predominant amino acid in the free pool of milk. CONCLUSIONS: Our results suggest that the metabolic use of amino acids and the presence of specific amino acid transport systems during lactation, contribute to specific concentrations of free amino acids in milk that were not associated with the pool of free amino acids in plasma. PMID- 9949672 TI - [Hematopoietic growth factors induce proliferation of non-hematopoietic tumor cells]. AB - OBJECTIVE: To evaluate the effect of hematopoietic growth factors (HGF) on the proliferation of non-hematopoietic cells such as fibroblasts and epithelial cells of normal and tumoral origin. METHODS: The lymphoid factor IL-2 and the myeloid HGF assayed were IL-3, G-CSF, GM-CSF and M-CSF. The cellular proliferation was determined by measuring the amount of crystal violet dye incorporation by cells through spectrophotometry. RESULTS: All myeloid HGF tested stimulated the proliferation of cell lines 5637, CaLo and L-929. These results suggest that the stromal cells can be induced to proliferate by myeloid growth factors hinting to a bilateral interaction between these two types of cells as it is known that stromal cells in turn secrete HGF. We also observed that for the mouse fibroblastic and epithelial cells, IL-2 was unable to induce proliferation in normal cells but had a strong effect on transformed cells. Finally we discuss our observation that tumour cells responded to IL-2 as a possible mechanism for an immune escape by these cells through IL-2 depletion. PMID- 9949673 TI - [Antibodies against Toxoplasma gondii in patients with HIV in Yucatan]. AB - OBJECTIVE: To determine the prevalence of antibodies type IgG to T. gondii in patients with HIV infection type 1 in the Yucatan peninsula. METHODS: 95 patients with HIV and 100 blood donors as controls were studied. The search for IgG antibodies to T. gondii was done with a third generation solid-phase enzyme immunoassay. Clinical and demographic data were obtained. RESULTS: The prevalence of antibodies was higher (p = 0.003) in controls (69%, CI95 = 59-78%) than in patients (47%, CI = 36-57%). No relation was found between seroreactivity and the variables evaluated (gender, urban or rural home, age) nor with CD4 T-cell counts and clinical categories. CONCLUSIONS: The high prevalence of T. gondii antibodies in both groups suggests that the zoonosis is endemic in the Yucatan peninsula. This justifies the routine determination of antibodies and the use of therapeutic protocols for preventing encephalitis by toxoplasma in HIV patients as a high percentage of them would be at risk of developing it. PMID- 9949674 TI - [Testicular lymphoma in two patients with AIDS and two without AIDS]. AB - OBJECTIVE: To describe the clinical, morphological and inmunophenotypic characteristics and followup of testicular non Hodgkin lymphomas seen in a referral center. METHODS: We reviewed the cases of testicular lymphoma seen from 1987 to 1997. We obtained data of laboratory tests, radiological findings, clinical course, treatment and new immunohistochemical studies (CD45, CD20, CD43, Epstein-Barr virus latent membrane protein and antibodies UCHL-1). We performed a blind analysis to identify the morphological variables associated to the clinical course. The Fisher exact test was used for statistical significance identification. RESULTS: 53 patients with testicular tumors were seen. Four of them were lymphomas (7.5%) with a mean age of 47 years (range 33-73) and two of the four had AIDS. A comparative analysis showed major local invasion of surgical margins and systemic progression in the AIDS cases. Immunohystochemical testing showed that the neoplasia was formed by B cells negative for Epstein-Barr virus latent membrane protein. The two patients without AIDS showed no evidence of the disease after 64 and 144 months of followup. The AIDS cases died one and three months after the diagnosis of testicular lymphoma was made. CONCLUSIONS: The four cases of testicular lymphoma were of B cell lineage without immunohystochemical expression for Epstein-Barr virus latent membrane protein. There was a more aggressive clinical course in the cases associated with AIDS. PMID- 9949675 TI - [First two years of an external quality assurance program for urinalysis]. AB - OBJECTIVE: To analyze the first two years of a strip uroanalysis quality assurance scheme operating in Mexico. METHODS: The participants received 8 shipments of four controls each as dried tablets to be dissolved and analyzed with urine strips. The number of participants increased from < 50 in the 1st shipment to > 200 in the 8th. They assayed 6-10 analytes depending on the strip used and sent in 763 reports. For each report we calculated a score per analyte (n = 4), per shipment (n = 24 to 40) and a global score in the 8 shipments (n = 707 to 763 reports). The scores ranged from zero (excellent accuracy) to a maximum of 400 and were calculated by comparison with the modal value of about 600 American and Canadian laboratories which assayed the same controls using exclusively Bayer strips and instrumental readings. RESULTS: The best score was for nitrites (global score of 3 in 741 reports) and the worst for specific gravity (58 in 744 reports); the other analytes had scores from 11 to 19 (Table 1). The scores of four types of methods (Table 2) showed the best results with Bayer strips and instrumental readings (score of 13 in 469 reports) and the worst with strips of other suppliers (scores of 28 for visual and 31 for instrumental readings) and intermediate with visual readings of Bayer strips (score of 21). CONCLUSIONS: 1. Our results led us to the decision to exclude from the program participants who do not use Bayer strips as our program may disorient them instead of helping to improve their assays. 2. We confirmed that instrumental readings perform better than visual readings. 3. The causes of suboptimal performance in specific gravity need to be explored. PMID- 9949676 TI - [Interpretation of negative clinical trials]. AB - Randomized clinical trials without statistically significant differences between treatment groups may provide useful information for clinicians. However, negative trials must be interpreted cautiously, since the absence of evidence of treatment effect is not the same as evidence of absence of treatment effect. Before the reader of a negative article can conclude that one intervention was not better than the other, the potential causes of a negative study should be explored. The objective of this manuscript is to critically describe some of the most common methodological problems that can explain the lack of difference between studied groups in randomized clinical trials. PMID- 9949677 TI - [Role of renal interstitial pressure on chronic control of arterial blood pressure]. AB - Several lines of evidence support the hypothesis that the kidney is involved in the generation and maintenance of arterial hypertension. The evidence comes from: 1) experimental models of hypertension showing that induction of all secondary forms of hypertension require some maneuvers to reduce the renal sodium and water excretion; 2) the existence of several rat models with genetic hypertension exhibiting a shift of the pressure-natriuresis relationship toward higher pressures; 3) renal transplantation experiments between normal and genetically hypertensive rats showing that hypertension follows the kidney; and 4) human genetic disease with chronic changes in arterial blood pressure levels in which all identified genes so far are part of a common pathway for renal sodium reabsorption. It is well known that pressure-natriuresis is the mechanisms by which any changes in arterial pressures are followed by changes in renal sodium excretion. However, it has been recognized now that the interstitial pressure in renal medulla is the linkage between arterial pressure levels and the amount of sodium reabsorption. Thus, the medullary interstitial pressure might be involved in the long-term control of systemic arterial pressure. Part of these new lines of evidence associating the renal medullary interstitial pressure in the control of arterial pressure are due to the availability of new methods such as laser doppler flowmetry and videomicroscopy, that allows the measurement of blood flow in renal cortex and medulla separately. Several studies with this methodology show that medullary, but not cortical pressure and blood flow correlate positively with natriuresis. What still remains unsolved is the mechanism by which renal sodium reabsorption increases or decreases after changes in the medullary interstitial pressure occur. PMID- 9949678 TI - [Clinical competence and incompetence]. PMID- 9949679 TI - G-protein-coupled, extracellular Ca(2+)-sensing receptor: a versatile regulator of diverse cellular functions. PMID- 9949680 TI - Peptide hormones, steroid hormones, and puffs: mechanisms and models in insect development. PMID- 9949681 TI - Nuclear matrix and steroid hormone action. PMID- 9949682 TI - Coregulatory proteins in nuclear hormone receptor action. PMID- 9949683 TI - Molecular action of androgen in the normal and neoplastic prostate. PMID- 9949684 TI - Regulation of androgen action. PMID- 9949685 TI - Regulation of estrogen action: role of 17 beta-hydroxysteroid dehydrogenases. PMID- 9949686 TI - Steroidogenic acute regulatory protein. PMID- 9949687 TI - Regulated expression of the bone-specific osteocalcin gene by vitamins and hormones. PMID- 9949688 TI - Benevolence. PMID- 9949689 TI - Release records and manage confidentiality? PMID- 9949690 TI - Pancreas divisum--the role of ERCP in children. AB - Pancreas Divisum (PD) is the most common congenital anomaly of the pancreas leading to chronic pancreatitis in children. The best diagnostic procedure to establish this diagnosis is Endoscopic Retrograde Cholangiopancreatography (ERCP). Utilizing ERCP as a therapeutic modality (sphincterotomy, stone removal), enables the clinician to improve symptoms and reduce morbidity. In this report, we describe the clinical presentation and outcome of three children with chronic pancreatitis who were subsequently diagnosed with PD by ERCP. We recommend that ERCP should be considered in children with chronic pancreatitis of unknown etiology. PMID- 9949691 TI - Carotid artery dissection: a challenging diagnosis. AB - Spontaneous extracranial internal carotid artery dissection (ICAD) is a rare vascular event. Even in the presence of existing signs and symptoms, the diagnosis can be missed by experienced clinicians of all specialties. This is a report of a patient who presented with symptomatic bilateral dissection manifested as partial Horner's syndrome. The diagnosis was made after several clinical evaluations with the use of duplex ultrasound and angiography. PMID- 9949692 TI - Guidelines for treating depression using non-selective serotonin reuptake inhibitors. AB - While the Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants are safe and effective agents that are frequently prescribed for the treatment of depression, non-SSRI antidepressants also have potential benefits to offer the depressed patient. A review of the literature offers guidelines for choosing between these two therapeutic categories. PMID- 9949693 TI - Women's health, chronic disease, and disease management: new words and old music? PMID- 9949694 TI - Chronic disease, women's health, and "disease management": the latest trend? PMID- 9949695 TI - Strategies for follow-up and treatment services in state breast and cervical cancer screening programs. AB - This report describes strategies used to provide diagnostic follow-up and treatment services to low-income women screened through the National Breast and Cervical Cancer Early Detection Program. PMID- 9949696 TI - Self-esteem differences as a function of race and weight preoccupation: findings and implications. AB - The relationship of weight and diet preoccupation and self-esteem among black and white college females is examined. PMID- 9949698 TI - Sib mating designs for mapping quantitative trait loci. AB - The power to separate the variance of a quantitative trait locus (QTL) from the polygenic variance is determined by the variability of genes identical by descent (IBD) at the QTL. This variability may increase with inbreeding. Selfing, the most extreme form of inbreeding, increases the variability of the IBD value shared by siblings, and thus has a higher efficiency for QTL mapping than random mating. In self-incompatible organisms, sib mating is the closest form of inbreeding. Similar to selfing, sib mating may also increase the power of QTL detection relative to random mating. In this study, we develop an IBD-based method under sib mating designs for QTL mapping. The efficiency of sib mating is then compared with random mating. Monte Carlo simulations show that sib mating designs notably increase the power for QTL detection. When power is intermediate, the power to detect a QTL using full-sib mating is, on average, 7% higher than under random mating. In addition, the IBD-based method proposed in this paper can be used to combine data from multiple families. As a result, the estimated QTL parameters can be applied to a wide statistical inference space relating to the entire reference population. PMID- 9949697 TI - Correlates of condom coupon redemption among urban sexually transmitted disease clinic patients. AB - This study expands upon coupon distribution strategies used to measure male condom acquisition in HIV/AIDS prevention by incorporating both female and male condoms and examining factors related to coupon redemption among urban STD clinic patients. PMID- 9949699 TI - Genetic analysis of extended life span in Drosophila melanogaster. I. RAPD screen for genetic divergence between selected and control lines. AB - Using lines selected for long life by Luckinbil and his co-workers, we screened two selected and two control lines for allelic frequency differences at 1200 randomly chosen RAPD marker loci. Twenty-three marker loci showed frequency differences in excess of 80%, and five were greater than 90%. Age-specific effects of the five most differentiated loci were estimated by collecting complete survival data in segregating backcross populations. Alleles at four of the five marker loci were associated with significant extension of life span in males, while two marker loci had significant effects in females. Eighty percent of the total selection response in males can be explained by the identified QTL's, under the assumption of additivity. The N14+ marker allele accounted for a 12-day life span extension in males, but had little effect in females. Both sex limited and sex-shared effects were observed. Analysis of age-specific mortality rates suggests that life span extension occurs by a combination of genetic factors that moderate both the level of mortality and the rate at which mortality increases with age. PMID- 9949700 TI - Genetic analysis of extended life span in Drosophila melanogaster. II. Replication of the backcross test and molecular characterization of the N14 locus. AB - We are interested in localizing chromosomal regions that extend life span in Drosophila. Using stocks artificially selected for long life by Luckinbill and his colleagues, we have identified marker loci that are highly divergent in allelic frequencies between replicated long-lived lines and controls (Curtsinger et al., 1998). Several of the most divergent loci have been found to be associated with effects on life span in segregating backcross populations. Here we report an independent replication of the backcross test for the N14 marker locus, previously reported to extend male life spans by 12 days. The life span effect successfully replicates in males. N14 accounts for 30% of the total selection response in males. Life span extension occurs by a decrease in age specific mortality rates at all ages, and is not attributable to modification of the slope of the age-specific mortality curve. The effect in females is small or nonexistent. Sequencing of the N14 locus shows that it is non-coding and not obviously regulatory, suggesting that the phenotypic effect arises from linkage disequilibrium with another locus or loci that directly affect life span. N14 DNA hybridizes to 63F/64A on the left arm of chromosome 3. The location is consistent with previous whole-chromosome substitution studies, and suggests new candidate genes for life span extension in Drosophila, including ras2. PMID- 9949701 TI - Identification of enhancer-like elements in the ribosomal intergenic spacer of Odontophrynus americanus 2n and 4n (Amphibia, Anura). AB - Repetitive elements are found in the ribosomal intergenic spacer (IGS) of most organisms. A particularly complex pattern of internal repetition occurs in the IGSs of O. americanus 2n and 4n, which are composed of several types of BamHI subrepeats (B-SRs). The most repetitive one is approximately 87 bp long, and is highly represented in the IGS variants of these amphibians. Sequence analyses of six diploid and two tetraploid B-SRs show 87% and 86% homology, respectively, and related secondary structure predictions. The comparison of the 2n and 4n B-SR sequences aligned with the 81 bp enhancer of Xenopus laevis reveals 36% homology. Furthermore, other B-SR features like size, number, and secondary structures resemble those of Xenopus enhancers, suggesting that B-SRs may function as regulators of O. americanus rDNA transcription. The present data also corroborate the close evolutionary relationship between 2n and 4n O. americanus species. PMID- 9949702 TI - Origin and decay of the P element-associated latitudinal cline in Australian Drosophila melanogaster. AB - The latitudinal cline in P transposable element-associated characteristics in eastern Australian populations of Drosophila melanogaster has changed between 1986 and 1991-1994. New collections were made in 1991-1994 from localities along the eastern coast of Australia. P element-associated properties of 256 isofemale lines from 43 localities were evaluated using gonadal dysgenesis and/or singed weak hypermutability assays. The overall results indicate that both P activity and P susceptibility have declined, with all populations showing a tendency towards a state with little P activity potential but with P repressor function (neutral or 'Q'). P repressor function is strong in all populations except some of the most southernly. P activity potential peaks at about 27 degrees SLat, and drops off to the south (as in 1983-1986 collections) and to the north (in contrast to 1983-1986 collections); thus the cline is no longer a simple P-to-Q to-M pattern from north to south, but is now Q-P-Q-M. A mtDNA RFLP that putatively distinguishes North American and European populations varies in frequency among the populations but the frequency does not vary clinically with latitude, ruling out massive introductions from North America and Europe as causing the cline. PMID- 9949703 TI - RNA expression from a site-specific non-LTR retrotransposon microinjected into Xenopus oocytes. AB - Tx1L is a site-specific non-LTR retrotransposon (NLR) that has been identified in the genome of Xenopus laevis. Using microinjection into Xenopus oocytes, several aspects of RNA expression by these elements were investigated. With constructs carrying various parts of the element we saw no evidence of promoter activity, unlike what has been shown for several other elements of this class. Tx1L transcription was induced by linking a whole element to a promoter that is active in oocytes. Among the RNAs produced, about half had 3' ends located near the end of the element, suggesting that instruction for 3' end formation are encoded in the element or its target. Deletion of the 3' UTR of Tx1L and of surrounding target sequences indicated that these regions are not required for termination or processing of the RNA. PolyA or very A-rich sequences were added at these 3' ends, despite the absence of canonical polyA addition signals. A significant proportion of non-A residues was found in the 3' untemplated tails, and this is reminiscent of non-templated insertions often found at the 3' junction of new genomic copies of some NLRs. PMID- 9949704 TI - Population database of STRs in west Africa: a genetic study of TPOX, HUMVWA31/A, HUMTH01, and CYP19. AB - Four tetrameric STRs (TPOX, HUMVWA31/A, HUMTH01, and CYP19) were analysed in a West African population (Cabo Verde). No significant deviations from Hardy Weinberg proportions were observed, either in conventional or exact tests. Pairwise comparisons confirmed allelic independence for all the combinations of loci. Data is provided for the first time about CYP19 in Black populations. In comparisons between African and Afro-American populations, significant frequency differences for several alleles at the TH01 and VWA31/A loci were observed. The allele frequencies provided in this study contribute to a better knowledge of the variability of these markers among the main human groups, especially in the context of Subsaharan African populations. PMID- 9949705 TI - Ironic effects of repetition: measuring age-related differences in memory. AB - Four experiments examined ironic effects of repetition, effects opposite to those desired (cf. D. M. Wegner, 1994). For an exclusion task, participants were to respond "yes" to words heard earlier but "no" to words that were read earlier. Results from young adults given adequate time to respond showed that false alarms to earlier-read words decreased with their repetition. An opposite, ironic effect of repetition was found for elderly adults--false alarms to earlier-read words increased with repetition. Younger adults forced to respond quickly or to perform a secondary task while reading words showed the same ironic effect of repetition as did elderly adults. The process-dissociation procedure (L. L. Jacoby, 1991, 1998) was used to show that factors that produce ironic effects do so by reducing recollection while leaving effects of repetition on familiarity unchanged. PMID- 9949706 TI - Age, testing at preferred or nonpreferred times (testing optimality), and false memory. AB - Two experiments investigated whether age and testing at preferred (optimal) times of day or nonpreferred (nonoptimal) times affected the ability to select relevant from irrelevant but thematically related alternatives in a verbal false memory paradigm. A 3rd experiment pursued the same issues with a visual false memory paradigm. In all 3 experiments, younger adults (n = 195) correctly recalled studied items more often than older adults (n = 121), whereas the 2 age groups correctly recognized about the same numbers of previously studied items. In all 3 experiments, nonoptimally tested older adults had more difficulty excluding nonstudied but thematically related items than the other groups; thus, they showed the greatest evidence of false memory, although all groups did so to a significant extent. The results suggest that optimality and its circadian determinants need to be considered with some tasks for the elderly. Various models and mechanisms are discussed. PMID- 9949707 TI - Priming of visual and functional knowledge on a semantic classification task. AB - Several lines of evidence suggest that semantic memory may be organized according to domain-specific attributes (e.g., visual or functional). Repetition priming both within and across these semantic knowledge domains was measured in 4 experiments to determine whether retrieval of one attribute can occur independently of retrieval of other attributes. The authors found a strong same attribute priming advantage that persisted even when the classification task differed between study and test. Also evident was a small but consistent cross attribute priming effect. Cross-attribute priming was not affected by changes in the modality of the test item, suggesting that the effect reflects the repetition of conceptual, and not perceptual, processes. On the basis of these results, the authors suggest that conceptual priming reflects the recapitulation of both domain-specific and nonspecific semantic processing. PMID- 9949708 TI - The effects of perceptual interference at encoding on organization and order: investigating the roles of item-specific and relational information. AB - Interfering with the perceptual processing of a stimulus can improve memory. The perceptual-interference effect was investigated from the perspective of the item specific/relational encoding distinction. This perspective suggests that perceptual interference enhances item-specific encoding but disrupts the encoding of relational and order information. The results of 6 experiments were largely consistent with this view. In Experiments 1 and 2, perceptual interference (a hypothesized item-specific manipulation) and list organization (a relational manipulation) both enhanced free recall but had opposite effects on a measure of relational processing (category clustering). Increasing list organization increased clustering, whereas perceptual interference decreased clustering. In addition, perceptual interference typically decreased memory for order. Finally, when order information was an important determinant of free recall, the perceptual-interference effect was eliminated or reversed. When reliance on order information was lessened, the perceptual-interference effect reemerged. PMID- 9949709 TI - Dimensions of mood in mood-dependent memory. AB - In this investigation of the roles of 2 different dimensions of mood (pleasantness and arousal) in mood-dependent memory (MDM), participants generated words while listening to a selection of independently rated mood music (normative study and Experiment 5). Then they recalled the words while listening to another mood-music selection (Experiments 1-3) or to a verbal-mood scenario (Experiment 4). Changing only the dimension of mood pleasantness from generation to recall decreased memory whether the intended moods were explicitly defined or not. However, changing only arousal decreased memory only when moods were defined. Thus, pleasantness-dependent memory, but not arousal-dependent memory, occurred consistently. Although MDM also occurred with simultaneous changes in both dimensions, the effect was not significantly greater than that of pleasantness dependent memory. The results are discussed in terms of 2-dimensional theories of emotion as applied to memory. PMID- 9949710 TI - Phonotactic influences on short-term memory. AB - The impact of phonotactic probabilities on serial recall was investigated in a series of experiments. In Experiments 1A and 1B, 7 and 8 year olds were tested on their serial recall of monosyllabic words and of nonwords varying in phonotactic frequencies. A recall advantage to words over nonwords remained when stimuli were balanced for phonotactic probability, but nonword recall showed superior accuracy for high over low probability nonwords, as in Experiment 2. The nonword frequency effect appears to reflect the frequency of constituent syllables rather than biphones. Both lexicality and high phonotactic frequency led to increased proportions of full over partial recall of the memory stimuli. These findings indicate that decayed memory traces in phonological short-term memory can be reconstructed using either lexical or phonotactic knowledge. PMID- 9949711 TI - Dissociating judgment from response processes in statement verification: the effects of experience on each component. AB - This research used the stochastic judgment model of statement verification to demonstrate a dissociation between judgment and response processes and investigated hypotheses about the effects of practice on each component. Data from respondents judging statements as true or false under various payoffs supported the dissociation and the following conclusions: Their ability to discriminate true from false depended on knowledge domain but not on payoffs. Experience with the domain did not improve this ability but did decrease the trial-by-trial confidence variability associated with memory search. Practice in a different domain had no such effect. Response criteria depended only on payoffs and experience. Criterion variability decreased with cumulative practice over domains. Most respondents had a bias to say "true" under symmetric payoffs, which did not dissipate with experience. Theoretical implications of the results are discussed. PMID- 9949712 TI - Mental representations of perspective and spatial relations from diagrams and models. AB - In previous research (D. J. Bryant, B. Tversky, & N. Franklin, 1992; N. Franklin & B. Tversky, 1990), the authors showed that spatial knowledge conveyed by descriptions and direct experience induces participants to take the perspective of a character surrounded by objects. In this study, the authors used models and diagrams to convey the same information. With models, as with descriptions and experience, participants adopted the character's perspective (the spatial framework analysis). With diagrams, participants took an outside perspective (the intrinsic computation analysis). Even when informationally equivalent, different depictions made salient different aspects of the world. When instructed, however, participants were able to take either the inside or the outside perspective in memory for both diagrams and models. Depth cues in depictions also govern participants' perspective. When diagrams contained rich pictorial depth cues, participants used the spatial framework analysis, and when models were viewed without access to depth cues, participants relied on the intrinsic computation analysis. PMID- 9949713 TI - The relationship between skill learning and repetition priming: experimental and computational analyses. AB - Skill learning and repetition priming are considered by some to be supported by separate memory systems. The authors examined the relationship between skill learning and priming in 3 experiments using a digit entering task, in which participants were presented with unique and repeated 5-digit strings with controlled sequential structure. Both skill learning and priming were observed across a wide range of skill levels. Performance reflected the effects of learning at 3 different levels of stimulus structure, calling into question a binary dichotomy between item-specific priming and general skill learning. Two computational models were developed which demonstrated that previous dissociations between skill learning and priming can occur within a single memory system. The experimental and computational results are interpreted as suggesting that skill learning and priming should be viewed as 2 aspects of a single incremental learning mechanism. PMID- 9949714 TI - Unusual modality effects in less-skilled readers. AB - University students who were skilled or less-skilled readers were compared on tests of auditory information processing and immediate serial recall of auditory and visual digits. Reading skill was defined by performance on a pseudoword reading task. The good readers exhibited typical modality effects with higher recall of auditory than visual items from the last 3 serial positions. On the terminal list item, the less-skilled readers showed a modality effect comparable with that of the skilled readers, but on other list items the modality effect reversed and a visual superiority was obtained. Results were discussed in terms of C. G. Penney's (1989) separate-streams model of short-term verbal memory. PMID- 9949715 TI - Building syntactic structure in speaking. AB - We investigated how people produce simple and complex phrases in speaking using a newly developed immediate recall task. People read and tried to memorize a target sentence, then read a prime sentence, then did a distractor task involving the prime sentence. Despite the delay and activity between memory and recall, people could still recall the target sentence although the syntactic form of the recalled sentence was influenced by the syntactic form of the prime sentence. This result replicates the syntactic priming effect found with other experimental paradigms. Using this task, we tested how people used abstract syntactic plans to produce simple and complex noun phrases. We found syntactic priming both when targets and prime sentences matched in complexity and when they did not match, suggesting that simple and complex noun phrases are built by the same syntactic routines during speech production. PMID- 9949716 TI - The effect of Arabic vowels on the reading comprehension of second- and sixth grade native Arab children. AB - This study investigated the effect of Arabic vowels on the reading comprehension of native Arabic speakers. This issue has not been addressed yet. Two groups of native Arabic speakers were randomly sampled, one from two elementary schools in the Haifa area, and the other from two elementary schools in Nazareth. Both groups in both experiments read Arabic texts in two reading conditions, vowelized and unvowelized; the older group (n = 74) answered 10 multiple-choice comprehension questions about each story, and the younger group (n = 71) answered seven multiple-choice comprehension questions. The results revealed that vowels were a significant facilitator of reading comprehension in both age groups. Considering these results, reading in Arabic orthography is not an autonomous word recognition process. An alternative approach is suggested for reading Arabic. PMID- 9949717 TI - Distraction of attention and the slope of the psychometric function. AB - The influential uncertainty model [J. Opt. Soc. Am. A 2, 1508 (1985)] attributes nonlinear contrast sensitivity near threshold to the inability of the observer to discriminate between the signal from stimulated locations and the noise from nonstimulated locations. We introduce an alternative interpretation, the distraction model, to describe the behavior of an observer who knows exactly which location was stimulated but may miss the test stimulus because attention has been distracted by irrelevant (noise) signals. For any stimulus sample, the observer is assumed to be certain of whether this sample is relevant or irrelevant to the stimulus. The non-linear effects predicted by the distraction model without uncertainty are similar to those predicted by the uncertainty model. PMID- 9949718 TI - Aging and the saturation of colors. 1. Colorimetric purity discrimination. AB - Colorimetric purity (Pc) discrimination functions were measured for 21 color normal observers (11 younger and 10 older observers with mean ages of 30 and 74 years, respectively). On each two-alternative-forced-choice trial, observers saw two flashes of light, a broadband white light [CIE(x, y) = (0.33, 0.35)] and a mixture of broadband and monochromatic light (420-680 nm). The observer's task was to choose the flash that had a chromatic component. Foveally viewed, circular, 1.2 degrees-diameter stimuli were presented as 1.5-s flashes with 3-s interstimulus intervals in Maxwellian view. Stimuli [250 trolands (td) and 10 td] were equated on the basis of individual heterochromatic flicker photometry functions. Measured Pc discrimination sensitivity was lower in the older group than in the younger group at both light levels, and the performance difference between the age groups was approximately constant across the spectrum. The difference between discrimination at 10 and 250 td was relatively small for the younger group but larger for the older group, indicating a selective performance decrement for older observers at low light levels. The data were modeled as a sum of differential responses from S-cone and L/M-cone chromatic channels. The model and the data indicate similar age-related losses of sensitivity in the two channels, perhaps secondary to receptorial sensitivity losses. PMID- 9949719 TI - Aging and the saturation of colors. 2. Scaling of color appearance. AB - Saturation of two sets of stimuli was scaled by 21 color-normal observers (ten younger and 11 older observers, mean ages: 30 and 73 years). Circular fields, 1.2 degrees in diameter, were presented in Maxwellian view as 1.5-s flashes with 3-s interstimulus intervals. Stimuli were mixtures of broadband light [CIE(x, y) = (0.35, 0.39), 200 trolands (td)] and monochromatic light (420-700 nm, 50 td). Monochromatic lights were equated by the 1978 2 degrees fundamental observer's luminosity function in one set of stimuli [J. J. Vos, Color Res. Appl. 3, 125 (1978) and by each observer's heterochromatic flicker photometry function in the other set of stimuli. Comparing the two age groups reveals no sizable differences in saturation for either set of stimuli, neither supporting nor refuting neural compensation for age-related increases in ocular media density (OMD). Examining short-wavelength saturation as a continuous function of estimated OMD reveals a more complicated pattern of results, however, suggesting substantial compensation over a certain range of OMD values but incomplete compensation for observers with the highest OMD values. PMID- 9949720 TI - Prophylactic octreotide reduces the severity of histopathologic changes and hemodynamic shock in early taurodeoxycholate-induced experimental pancreatitis. AB - The findings related to the effects of somatostain and octreotide in experimental and clinical acute pancreatitis are so far inconclusive. In this study, we examined the early effects of prophylactic octreotide in acute experimental pancreatitis. Serum levels of amylase and lipase, pancreatic histopathology and systemic hemodynamic profiles, including mean arterial pressure, cardiac index, systemic vascular resistance and heart rate, were evaluated 5 hours after glycodeoxycholic acid (GDOC) or sodium taurodeoxycholate (TDC)-induced pancreatitis with or without prophylactic octreotide (10 micrograms/Kg) in rats, GDOC and TDC induced mild and severe pancreatitis, respectively. Octreotide significantly reduced serum levels of amylase and lipase at 5 hours in GDOC and TDC-induced pancreatitis. Octreotide significantly reduced the severity of pancreatic edema, necrosis and hemorrhage in TDC-induced pancreatitis. In addition, hemodynamic shock in TDC-induced pancreatitis was improved significantly by the administration of octreotide (mean arterial pressure 70.3 +/ 7.7 vs. 95.0 +/- 3.5 mmHg, p < 0.05; cardiac index 16.7 +/- 2.5 vs. 24.0 +/- 5.1 ml.min-1. 100 g-1, p < 0.05). However, octreotide did not show significant beneficial effect in pancreatic histopathology and hemodynamics in GDOC-induced pancreatitis. Thus we conclude that prophylactic octreotide improves pancreatic histopathology and hemodynamic shock in TDC-induced pancreatitis. PMID- 9949721 TI - A statistical approach to data analysis and 3-D geometric description of the human head and face. AB - Many analytical biomechanical methods require extensive three-dimensional statistical description of anatomical geometry. In particular, to design personal protective items for the human head and face, where good fit is critical, it is inevitable that a three-dimensional statistical description of this complicated structure will be needed. The work here offers an approach to this problem. This approach consists of three steps: (1) osteometric scaling, (2) normative specimen accumulation and (3) statistical testing. Three groups of facial data (24 Asian, 29 Black, and 29 White) were digitized. The effectiveness and accuracy of the statistical approach was tested on these three different experimental specimen sets. The method was found to be very accurate in modelling the most complicated human body parts--head and face. The availability of this detailed geometric information will also open many doors for future research and development of muscle controlled prostheses, repair of ligament damage, and in-vivo bone remodelling. PMID- 9949723 TI - Identification of a novel family of human Rab-like small GTP-binding proteins. AB - The presence of a novel family of Rab-like proteins (Rlp) in the human genome is reported. The gene encoding the Rlp-2 was isolated from a human lymphocyte genomic library. The Rlp-2 gene is intronless and was mapped to chromosome Xq21.3 using fluorescence in situ hybridization. Several cDNA clones encoding the Rlp-1 were identified in a human hippocampus lambda library. Northern analysis revealed a 2.1-kb transcript of Rlp-1 expressed predominantly in brain, heart and skeletal muscle. The transcript was also observed in all examined regions of the human brain at a similar level. An additional gene, termed Rlp-3, which is highly related to Rlp-1 and Rlp-2, was found in the GenBank Data Base. The predicted molecular mass for Rlp is approximately 31 kDa and is consistent with that of Rlp 1 synthesized in Escherichia coli. PMID- 9949722 TI - The structural, biochemical, and genetic characterization of a new radiation induced, variegated leaf mutant of soybean [Glycine max (L.) Merr]. AB - A variegated leaf mutant in soybean [Glycine max (L.) Merr.] has been identified and characterized. E25-10 was derived by exposure of seeds of the "Williams' 82" cultivar to gamma-radiation. In this mutant, yellow leaf sectors contain defective chloroplasts, in which the thylakoid membranes are presented as long, parallel structures with little or no overlap. No starch grains have been detected in the mutant chloroplasts. Small vesicles and plastoglobuli can be found within the defective chloroplasts. Genetic studies revealed that a single nuclear-encoded gene is responsible for the mutation in E25-10. The total chlorophyll content is reduced in yellow leaf tissue by 70-80%. However, the chlorophyll a/b ratio is not altered. The absorbance spectrum of pigments in the mutant leaf tissue differed from that of the green extracts in the range of 400 500 nm. This reduction in total chlorophyll and the change in the absorbance spectrum pattern in the yellow tissue is related to a loss of certain photosynthetic complexes. Green gel analysis revealed that four major pigment protein complexes (CP1, LHCP1, LHCP2, and CPa) of the thylakoid membranes were absent in the E25-10 mutant. Lithium dodecyl sulphate polyacrylamide gel analysis showed that at least 5-6 polypeptides (51, 44, 25, 15, 13, and 12 kDa) were missing in the thylakoid membranes of chloroplasts from the yellow tissue. Changes in chloroplast- and nuclear-encoded gene message levels were detected. The psaA transcripts which code for the P700 apoprotein in PSI were reduced in chloroplasts from the E25-10 mutant yellow tissue. The levels of the large subunit of ribulose bisphosphate carboxylase (rbcL) and light harvest complex protein (LHCP) of PSII mRNA appeared to be reduced slightly in the mutant plants. However, a much more significant reduction in the 16S rRNA and the small subunit of ribulose bisphosphate carboxylase (rbcS) expression was detected in the yellow leaf sectors. Our results suggest that the possible lesion in E25-10 is located in the photosystem I even though fewer grana were observed in the defective chloroplasts. PMID- 9949724 TI - ESI/ion trap/ion mobility/time-of-flight mass spectrometry for rapid and sensitive analysis of biomolecular mixtures. AB - An ion trap/ion mobility/time-of-flight mass spectrometry technique is shown to be a rapid and sensitive means of analyzing peptide/protein mixtures. In this approach, an ion trap is used to accumulate ions that have been electrosprayed from a mixture into concentrated packets. The ion packets are injected into a drift tube where components of the mixture are separated based on differences in mobility through a buffer gas. Ions that exit the drift tube are dispersed in a time-of-flight mass spectrometer for mass-to-charge (m/z) determination. The gas phase separation strategy reduces congestion in the mass spectrum, and experimental mobilities complement m/z measurements in assigning peaks. Examples of the application of the approach to identification of peptides (from tryptic digests) and to separation of charge-state distributions from electrospray of a mixture containing ubiquitin and myoglobin are presented. Most peptides that are observed from tryptic digests of proteins such as cytochrome c and myoglobin can be identified from data that are acquired in under 1 min; studies of mixtures with known compositions indicate that detection limits are approximately 0.5-3 pmol for individual components. Factors that may influence the distributions that are observed, such as storage time in the trap, injection voltages used for the mobility experiment, and variations in ion cross section with charge state, are discussed. PMID- 9949726 TI - Micellar liquid chromatography: a worthy technique for the determination of beta antagonists in urine samples. AB - Several beta-antagonists (acebutolol, atenolol, celiprolol, labetalol, metoprolol, nadolol, propranolol) were determined in urine samples with fluorometric detection after direct injection, in less than 15 min, with a micellar mobile phase of 0.1 M sodium dodecyl sulfate (SDS), 15% propanol, and 1% triethylamine at pH 3. The limits of detection (38 criterion) were usually between 3 and 30 ng/mL. The addition of propanol and triethylamine and the reduction of the pH of the mobile phase improved the efficiency of the chromatographic peaks that was rather low in pure micellar eluents. The selection of the composition of the mobile phase was easily performed through the use of an interpretive procedure which considered the retention times and peak shapes of the beta-antagonists in six chromatograms, obtained at varying concentrations of SDS (0.05-0.15 M) and propanol (5-15% v/v). The chromatograms of urine samples from healthy volunteers, which were administered atenolol, metoprolol, and propranolol, showed only one peak for the former drug and several peaks for the other two. These peaks corresponded to the parent drug and metabolites, which indicated the partial and the extensive degradation of metoprolol and propranolol, respectively. PMID- 9949725 TI - Monoclonal antibody-based ELISAs for part-per-billion determination of polycyclic aromatic hydrocarbons: effects of haptens and formats on sensitivity and specificity. AB - As a first step toward developing sensitive enzyme-linked immunosorbent assays (ELISAs) for multianalyte detection of polycyclic aromatic hydrocarbons (PAHs), haptens with different lengths of carboxylic acid spacers at various positions were derived from naphthalene, fluorene, anthracene, phenanthrene, pyrene, fluoranthene, chrysene, and benzo[a]pyrene (BaP). These haptens were coupled with bovine serum albumin (BSA) to form competitor conjugates. All of these haptens were recognized to different extents by monoclonal antibodies (MAbs) 4D5 and 10C10 originally derived by Gomes and Santella (Chem. Res. Toxicol. 1990, 3, 307 310). The most sensitive indirect ELISAs were obtained by coating wells with the least competitive conjugates. Direct ELISAs using horseradish peroxidase conjugates of pyrene and BaP were less sensitive. The MAbs bound BaP with spacers at either C1 or C6. The cross-reactivity profiles of the eight PAHs were different with each PAH-BSA conjugate used as coating antigen. The ELISA results for BaP closely correlated with those by gas chromatography (GC), but the detection limit of the ELISA was approximately 150-fold more sensitive than that of GC, with 2-600 nM spike recoveries of 80-127% from human urine and canal and tap water. PMID- 9949727 TI - DNA biochip using a phototransistor integrated circuit. AB - This work describes the development of an integrated biosensor based on phototransistor integrated circuits (IC) for use in medical detection, DNA diagnostics, and gene mapping. The evaluation of various system components developed for an integrated biosensor microchip is discussed. Methods to develop a microarray of DNA probes on nitrocellulose substrate are discussed. The biochip device has sensors, amplifiers, discriminators, and logic circuitry on board. Integration of light-emitting diodes into the device is also possible. To achieve improved sensitivity, we have designed an IC system having each phototransistor sensing element composed of 220 phototransistor cells connected in parallel. Measurements of fluorescent-labeled DNA probe microarrays and hybridization experiments with a sequence-specific DNA probe for the human immunodeficiency virus 1 system on nitrocellulose substrates illustrate the usefulness and potential of the DNA biochip. PMID- 9949728 TI - Polymer-based lanthanide luminescent sensor for detection of the hydrolysis product of the nerve agent Soman in water. AB - The techniques of molecular imprinting and sensitized lanthanide luminescence have been combined to create the basis for a sensor that can selectively measure the hydrolysis product of the nerve agent Soman in water. The sensor functions by selectively and reversibly binding the phosphonate hydrolysis product of this agent to a functionality-imprinted copolymer possessing a coordinatively bound luminescent lanthanide ion, Eu3+. Instrumental support for this device is designed to monitor the appearance of a narrow luminescence band in the 610-nm region of the Eu3+ spectrum that results when the analyte is coordinated to the copolymer. The ligand field shifted luminescence was excited using 1 mW of the 465.8-nm line of an argon ion laser and monitored via an optical fiber using a miniature spectrometer. For this configuration, the limit of detection for the hydrolysis product is 7 parts per trillion (ppt) in solution with a linear range from 10 ppt to 10 ppm. Chemical and spectroscopic selectivities have been combined to reduce the likelihood of false positive analyses. Chemically analogous organophosphorus pesticides tested against the sensor have been shown to not interfere with determination. PMID- 9949729 TI - Characterization of allosteric insulin hexamers by electrospray ionization mass spectrometry. AB - Electrospray mass spectrometry is used at pH 8.0 in combination with accurate mass measurements to confirm the multiplicity of insulin in stable noncovalent complexes with Zn(II) ions. Determination of the nature and number of ligands involved in Zn(II) chelation is in agreement with crystal and solution structures. Counting the number of ligands participating in each center allows deduction of the geometric configuration of the ligand field and gives indirect information about the conformational state of the insulin monomers in solution. PMID- 9949730 TI - Postcolumn reaction detection with dual-electrode capillary electrophoresis electrochemistry and electrogenerated bromine. AB - This is the first report of postcolumn amperometric reaction detection for capillary electrophoresis and dual-electrode detection. Bromide present in the run buffer is oxidized to bromine at the first electrode and subsequently detected at a second electrode downstream. Analytes that react with bromine cause a decrease in signal at the downstream electrode that is proportional to analyte concentration. Bromine is known to react with a variety of compounds, including thiols, thioethers, disulfides, amines, and unsaturated organic compounds. In this paper, the development of a new wire--wire on-capillary dual electrode that is well suited to bromine-based post-column reaction detection is described. System performance was evaluated using glutathione, cysteine, and methionine as test analytes. The final optimized system could be operated continuously for 24 h and was stable for day-to-day use for at least two weeks. The response for cysteine was linear from 0.5 to 20 microM with a limit of detection of approximately 80 nM. PMID- 9949731 TI - An array immunosensor for simultaneous detection of clinical analytes. AB - A fluorescence-based immunosensor has been developed for simultaneous analysis of multiple samples. A patterned array of recognition elements immobilized on the surface of a planar waveguide is used to "capture" analyte present in samples; bound analyte is then quantified by means of fluorescent detector molecules. Upon excitation of the fluorescent label by a small diode laser, a CCD camera detects the pattern of fluorescent antigen:antibody complexes on the sensor surface. Image analysis software correlates the position of fluorescent signals with the identity of the analyte. This immunosensor was used to detect physiologically relevant concentrations of staphylococcal enterotoxin B (SEB), F1 antigen from Yersinia pestis, and D-dimer, a marker of sepsis and thrombotic disorders, in spiked clinical samples. PMID- 9949732 TI - Characterization of transthyretin mutants from serum using immunoprecipitation, HPLC/electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry. AB - A mass spectrometry approach for the detection and identification of variants of the plasma protein transthyretin (TTR) is presented. The single amino acid substitutions found in TTR are closely associated with familial transthyretin amyloidosis (ATTR), a hereditary degenerative disease. A definitive diagnosis of ATTR relies on the detection and identification of TTR variants. The approach presented here is based on isolation of serum TTR using immunoprecipitation. The detection of the variant is achieved by mass measurement of the intact protein with electrospray ionization mass spectrometry (ESIMS). The liquid chromatography/ESIMS analysis of the tryptic digest of the protein followed by subsequent matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry and MALDI postsource decay of the relevant recovered chromatographic fraction containing the variant peptide allows the identification of unknown variants. The method was successfully tested using serum from ATTR patients with known variants (Val30-->Met and Val122-->Ile). A new TTR variant, Ser23-->Asn, was detected and identified using the above method where isoelectric focusing and restriction enzyme analysis failed to identify the nature of the variant. PMID- 9949733 TI - Phase correction for collision model analysis and enhanced resolving power of fourier transform ion cyclotron resonance mass spectra. AB - Phase correction of FT-ICR data yields an absorption spectrum that offers a gain by up to a factor of 2 in mass resolving power (at half-maximum peak height), compared to conventional magnitude-mode display. That improvement is equivalent to doubling the applied magnetic field strength, without loss in signal-to-noise (S/N) ratio, provided that the time-domain data are padded with an equal number of zeroes before FFT. Our simple, visual, user-interactive algorithm quickly corrects for zero-order and first-order variation of phase with frequency. We find that the theoretical mass resolving power enhancement for pressure-limited absorption-mode over magnitude-mode line shape depends on the collision mechanism: factor of 1.40 for hard sphere vs 3(1/2) for Langevin (ion: induced dipole). Thus, the experimental enhancement in mass resolving power (factor of 1.43 +/- 0.09) for isotopically resolved peaks in the FT-ICR mass spectra of electrosprayed bovine carbonic anhydrase (approximately 29 kDa) directly supports the hard-sphere collision model. Optimal implementation of phasing requires the following: (a) a delay between excitation and detection of less than half of one sampling interval to avoid baseline "roll" and Gibb's oscillations; (b) accurate analog-to-digital conversion; (c) a sufficiently long acquisition period to yield several data points per absorption-mode peak width at half-maximum peak height; and (d) avoidance of FT-ICR apodization functions (e.g., Hamming and Hanning) that suppress the initial time-domain data. Pulsed single-frequency excitation (duration much less than the reciprocal of the Nyquist bandwidth) can eliminate higher than first-order variation of phase with frequency. Phased FT-ICR spectra should prove especially desirable for analysis of complex mixtures, for resolving isotopic distributions in electrosprayed multiply charged macromolecules and for characterizing ion collisions (and thus ion size and shape). PMID- 9949734 TI - Structural analysis of glycoconjugates by on-target enzymatic digestion and MALDI TOF-MS. AB - Exoglycosidase digestion combined with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has been demonstrated to be an effective method for the structural characterization of glycoconjugates and oligosaccharides in picomolar amounts. A sample preparation method is described, in which 6-aza-2-thiothymine (ATT) in water is used as matrix and enzymes are dialyzed before use against a low concentration of volatile buffer such as ammonium acetate. Under these conditions, a series of sequential on-target exoglycosidase treatments was carried out in one single analyte spot in the presence of ATT matrix. Subsequent mass spectrometric analysis of the resulting products yielded information on both the completeness of the reaction and structural features of the glycoconjugates such as monosaccharide sequence, branching pattern, and anomeric configurations of the corresponding glycosidic linkages. The results show that all exoglycosidases used retain their activity in the presence of ATT matrix. Hence, structural analysis of carbohydrates or mixtures thereof can be performed very fast, without intermediate desalting steps or sample splitting. This approach is illustrated by the analysis of underivatized glycans, oligosaccharide derivatives, glycopeptides, and glycolipids. Depending on the analyte, amounts of sample required could be limited to a few picomoles. PMID- 9949735 TI - Utility of wiring nitrate reductase by alkylpyrroleviologen-based redox polymers for electrochemical biosensor and bioreactor applications. AB - The purpose of this work was to see if the alkylpyrroleviologen redox polymer technology previously developed for a reagentless nitrate biosensor based on nitrate reductase (NaR) from Escherichia coli (Cosnier, S.; Innocent, C.; Jouanneau, Y. Anal. Chem. 1994, 66, 3198-3201) could be applied to the isozyme from Aspergillus niger. In particular, the enzyme viability after immobilization was of great interest, as Cosnier et al. reported a residual activity of only 0.33% of the amount initially applied. The present work showed that A. niger NaR lost 99.2% of soluble activity on vacuum-drying in the presence of 2.5 nM N methyl-N'-(12-[pyrrol-1-yl]dodecyl)-4,4'-bipyridinium ditetrafluoroborate monomer (C12V2+) and that most of this loss was due to monomer inhibition (91%). The loss due to dehydration was only 8%. In the biosensor configuration, the enzyme gave a residual activity of 0.18% of the amount originally applied and a specific response of 1.7 mA M-1 cm-2, but all activity was lost after 4 d storage at 4 degrees C in phosphate buffer. It was concluded that for practical biosensors and bioreactors, modification of the redox polymer format was needed, for example by covalent immobilization, to effect higher loading of viable NaR and improved enzyme stability. PMID- 9949736 TI - Use of poly(tetrafluoroethylene)s as a sample support for the MALDI-TOF analysis of DNA and proteins. AB - Matrix-assisted laser desorption/ionization mass spectrometry of DNA and proteins, directly deposited on the poly(tetrafluoroethylene) (Teflon) surface, is demonstrated. For DNA analysis, this technique apparently produces a more homogeneous coverage of the matrix/DNA over the sample surface. Moreover, it enhances the sensitivity and salt tolerance. As described here, this technique can also achieve an excellent mass resolution, similar to that observed using a metal probe for DNA up to 62mer. We also examined the use of Teflon as a sample support for protein analysis since Teflon has been used as a transfer membrane. Less than 25 fmol of myoglobin has been detected with this technique. In addition, effective MALDI-TOF analysis of salt-contaminated protein samples can also be accomplished by loading the protein sample onto Teflon, followed by steps of washing away salts, adding the matrix, and desorbing sample directly from Teflon. PMID- 9949737 TI - Assessment of risk from multimedia exposures of children to environmental chemicals. PMID- 9949738 TI - Medical waste treatment and disposal methods used by hospitals in Oregon, Washington, and Idaho. AB - This study investigated medical waste practices used by hospitals in Oregon, Washington, and Idaho, which includes the majority of hospitals in the U.S. Environmental Protection Agency's (EPA) Region 10. During the fall of 1993, 225 hospitals were surveyed with a response rate of 72.5%. The results reported here focus on infectious waste segregation practices, medical waste treatment and disposal practices, and the operating status of hospital incinerators in these three states. Hospitals were provided a definition of medical waste in the survey, but were queried about how they define infectious waste. The results implied that there was no consensus about which agency or organization's definition of infectious waste should be used in their waste management programs. Confusion around the definition of infectious waste may also have contributed to the finding that almost half of the hospitals are not segregating infectious waste from other medical waste. The most frequently used practice of treating and disposing of medical waste was the use of private haulers that transport medical waste to treatment facilities (61.5%). The next most frequently reported techniques were pouring into municipal sewage (46.6%), depositing in landfills (41.6%), and autoclaving (32.3%). Other methods adopted by hospitals included Electro-Thermal-Deactivation (ETD), hydropulping, microwaving, and grinding before pouring into the municipal sewer. Hospitals were asked to identify all methods they used in the treatment and disposal of medical waste. Percentages, therefore, add up to greater than 100% because the majority chose more than one method. Hospitals in Oregon and Washington used microwaving and ETD methods to treat medical waste, while those in Idaho did not. No hospitals in any of the states reported using irradiation as a treatment technique. Most hospitals in Oregon and Washington no longer operate their incinerators due to more stringent regulations regarding air pollution emissions. Hospitals in Idaho, however, were still operating incinerators in the absence of state regulations specific to these types of facilities. PMID- 9949739 TI - Impact of residential nitrogen dioxide exposure on personal exposure: an international study. AB - Nitrogen dioxide (NO2) concentrations were measured during two-day winter periods in indoor and outdoor environments, and these concentrations were compared with simultaneously measured personal exposures in 18 cities in 15 countries around the world. Information was also gathered on activity patterns and household characteristics in order to determine the influences of these factors on personal exposures. All NO2 measurements were taken using passive filter badges. Personal exposures were found to vary greatly among the array of cities, with mean concentrations ranging between 11.0 ppb and 51.5 ppb. Personal NO2 exposures were more strongly correlated with indoor concentrations (r = 0.75) than with outdoor concentrations (r = 0.57) when all countries were considered simultaneously. Use of a gas stove in the home was the dominant activity influencing NO2 concentrations, with a 67% increase in mean personal NO2 exposure and an increase in indoor-outdoor ratios from 0.7 to 1.2 for participants using gas stoves, although preliminary evidence indicates the importance of combustion space heaters as well. These associations indicate the global nature of the correlation between personal NO2 exposures and indoor NO2 sources such as gas stoves or space heaters, demonstrating that this relationship is not dependent on country specific parameters. PMID- 9949740 TI - Promoting the health and well-being of future generations. PMID- 9949741 TI - Annotation: children's disengagement from medical homes--a neglected public health imperative. PMID- 9949742 TI - Who should be offered prenatal diagnosis? The 35-year-old question. AB - Prenatal diagnosis of chromosomal disorders is generally offered to women who will be 35 years or older at the time of delivery or who have been determined via serum screening to be at risk similar to that of a woman older than 35 years. This age threshold was based on 4 major rationales that reflect considerations of resources and effectiveness. In this paper, we explore the current screening recommendations and consider new information that calls the 35-years threshold into question. We conclude that guidelines regarding use of prenatal diagnosis account for the preferences of the individual patient as well as for individual risk. PMID- 9949743 TI - The role of state policies and programs in buffering the effects of poverty on children's immunization receipt. AB - OBJECTIVES: This study assessed the influence of public policies on the immunization status of 2-year old children in the United States. METHODS: Up-to dateness for the primary immunization series was assessed in a national sample of 8100 children from the 1988 National Maternal and Infant Health Survey and its 1991 Longitudinal Follow-Up. RESULTS: Documented immunization rates of this sample were 33% for poor children and 44% for others. More widespread Medicated coverage was associated with greater likelihood of up-to-dateness among poor children. Up-to-dateness was more likely for poor children with public rather than private sources of routine pediatric care, but all children living in states where most immunizations were delivered in the public sector were less likely to be up to date. Poor children in state with partial vaccine replacement programs were less likely to be up to date than those in free-market purchase states. CONCLUSIONS: While state policies can enhance immunization delivery for poor children, heavy reliance on public sector immunization does not ensure timely receipt of vaccines. Public- and private-sector collaboration is necessary to protect children from vaccine-preventable diseases. PMID- 9949744 TI - The impact of physician bonuses, enhanced fees, and feedback on childhood immunization coverage rates. AB - OBJECTIVES: The purpose of this study was to examine the effects on immunization coverage of 3 incentives for physicians--a cash bonus for practice--wide increases, enhanced fee for service, and feedback. METHODS: Incentives were applied at 4-month intervals over 1 year among 60 inner-city office-based pediatricians. At each interval, charts of 50 randomly selected children between 3 and 35 months of age were reviewed per physician. RESULTS: The percentage of children who were up to date for diphtheria, tetanus, and pertussis and Haemophilus influenzae type b; polio; and measles-mumps-rubella immunization in the study's bonus group improved by 25.3 percentage points (P < .01). No significant changes occurred in the other groups. However, percentage of immunizations received outside the participating practice also increased significantly in the bonus group (P < .01). Levels of missed opportunities to immunize were high in all groups and did not change over time. Physicians' knowledge of contraindications was low. CONCLUSIONS: Bonuses sharply and rapidly increased immunization cover-age in medical records. However, much of the increase was the result of better documentation. A bonus is a powerful incentive, but more structure or education may be necessary to achieve the desired results. PMID- 9949745 TI - The effectiveness of the Reach for Health Community Youth Service learning program in reducing early and unprotected sex among urban middle school students. AB - OBJECTIVES: This study evaluated the effectiveness of a community youth service (CYS) program in reducing sexual risk behaviors among African American and Latino urban young adolescents. METHODS: A total of 1061 students at 2 urban middle schools were surveyed at baseline and 6-month follow-up. Students at one school were randomly assigned by classroom to receive either the Reach for Health CYS program or the Reach for Health classroom curriculum only. Students at the other school served as controls. RESULTS: At follow-up. CYS participants reported significantly less recent sexual activity (P < .05) and scored lower on a sexual activity index than those in the control condition (P < .03). The greatest effect was among eighth graders, who received the most intensive service program (P < .03). The benefit of the curriculum-only intervention appeared greatest among students in special education classes. CONCLUSIONS: Well-organized CYS that couples community involvement with classroom health instruction can have a positive impact on the sexual behaviors of young adolescents at risk for HIV, sexually transmitted diseases, and unintended pregnancy. This study also suggests the importance of including students in special education classes in health education programs. PMID- 9949746 TI - The impact of condom availability [correction of distribution] in Seattle schools on sexual behavior and condom use. AB - OBJECTIVES: Ten Seattle high schools made condoms available through vending machines, baskets in school clinics, or both. This study measured the number of condoms that students obtained and subsequent changes in sexual behavior and condom use. METHODS: Schoolwide surveys were administered in spring 1993 and in spring 1995, before and during the condom availability program. These data were compared with data from nationally representative surveys administered at the same time. RESULTS: Seattle students obtained an average of 4.6 condoms per year, the vast majority from baskets and very few from vending machines. Relative to the national samples, the percentage of Seattle students who had ever had sex remained stable after the program began; current sexual activity decreased significantly; and the percentage of sexually experienced students who used a condom the last time they had sex decreased significantly, particularly in the 5 schools with baskets of condoms in clinics. CONCLUSIONS: Making condoms available in Seattle schools enabled students to obtain relatively large numbers of condoms but did not lead to increases in either sexual activity or condom use. PMID- 9949747 TI - Interior surface materials in the home and the development of bronchial obstruction in young children in Oslo, Norway. AB - OBJECTIVES: This study assessed the role of polyvinyl chloride (PVC) plastics and textile materials in the home in the development of bronchial obstruction during the first 2 years of life. METHODS: The study was a matched pair case-control study based on a cohort of 3754 newborns in Oslo in 1992 and 1993 who were followed up for 2 years. The case group consisted of 251 children with bronchial obstruction; the control group was matched one-to-one for date of birth. RESULTS: In conditional logistic regression analysis, the risk of bronchial obstruction was related to the presence of PVC flooring (adjusted odds ratio [OR] = 1.89; 95% confidence interval [CI] = 1.14, 3.14) and textile wall materials (adjusted OR = 1.58; 95% CI = 0.98, 2.54). The reference category was wood or parquet flooring and painted walls and ceiling. Further analysis revealed an exposure-response relationship between the assessed amount of PVC and other plasticizer-containing surface materials and the risk of bronchial obstruction. CONCLUSIONS: This study provides new evidence of the role of PVC and textile wall materials in the development of bronchial obstruction in young children. PMID- 9949748 TI - Measurement of the validity of a preschool vision screening program. AB - OBJECTIVES: The validity (sensitivity and specificity) of a preschool vision screening program was measured over a 3-year period to determine how well strabismus and significant refractive errors could be detected. METHODS: Public health nurses were trained to administer tests of visual acuity, stereoacuity, and ocular alignment. Failure on any test, visual acuity of 6/9 or less, stereoacuity of less than 100 seconds of arc, or an apparent misalignment of the eyes resulted in referral to an eye care practitioner. An age-matched control was also referred. Analysis of practitioner reports used predefined study-based criteria for ocular abnormalities. RESULTS: More than 1100 children were screened each year. The annually calculated prevalence of vision problems ranged between 10.5% and 13.8%. The estimated sensitivity varied from 60.4% to 70.9% (specificity, 69.6% to 79.9%). The yield indicated that a very high percentage of children with vision problems were identified for the first time. CONCLUSIONS: The validity of this screening is comparable to that of other school screenings. The limitations are predictable. Consideration should be given to replacing visual acuity tests with a rapid, objective measure of refractive error and ocular alignment. PMID- 9949749 TI - Roe v Wade and American fertility. AB - OBJECTIVES: This article examines the effect of abortion legalization on fertility rates in the United States. METHODS: Fertility rates were compared over time between states that varied in the timing of abortion legalization. RESULTS: States legalizing abortion experienced a 4% decline in fertility relative to states where the legal status of abortion was unchanged. The relative reductions in births to teens, women more than 35 years of age, non-White women, and unmarried women were considerably larger. If women did not travel between states to obtain an abortion, the estimated impact of abortion legalization on birth rates would be about 11%. CONCLUSIONS: A complete recriminalization of abortion nationwide could result in 440,000 additional births per year. A reversal of the Roe v Wade decision leaving abortion legal in some states would substantially limit this impact because of the extent of travel between states. PMID- 9949750 TI - Implementation of condom social marketing in Louisiana, 1993 to 1996. AB - OBJECTIVES: This article describes the implementation and impact of the first statewide condom social marketing intervention in the United States. METHODS: A statewide social marketing program made condoms freely available in 93 public health clinics, 39 community mental health centers, 29 substance abuse treatment sites, and more than 1000 businesses in neighborhoods with high rates of sexually transmitted diseases (STDs) and HIV. Surveys about condom use were conducted annually. RESULTS: Between 1994 and 1996, more than 33 million condoms were distributed without significant opposition. Over time, self-reported condom use at the last sexual encounter increased among African American women (from 28% in 1994 to 36% in 1996), particularly African American women with 2 or more sex partners (from 30% to 48%). Condom use at the last sexual encounter increased among African American men (from 40% in 1994 to an average of 54% in 1996). The number of reported sex partners did not increase. CONCLUSIONS: Condom social marketing can be successfully implemented in the United States. The widespread availability of free condoms is associated with increased condom use, particularly among persons at high risk for STDs and HIV. PMID- 9949751 TI - Prevalent urinary incontinence as a correlate of pregnancy, vaginal childbirth, and obstetric techniques. AB - OBJECTIVES: This study examined the association between pregnancy, vaginal childbirth and obstetric techniques, and the prevalence of urinary incontinence among adult women aged 20 to 59 years. METHODS: A cross-sectional survey enrolled a random sample of 6240 women aged 20 to 59 years who were mailed a self administered questionnaire focusing on urinary incontinence and other health variables. More than 75% of the women responded. The present analysis includes 4345 women who were not pregnant and did not experience a vaginal childbirth during 1994. RESULTS: Multivariate prevalence odds ratios showed increases in relation to urinary incontinence during pregnancy, urinary incontinence immediately after a vaginal childbirth, and age of 30 years or more at the second vaginal childbirth. No multivariate associations were found for forceps delivery or vacuum extraction delivery, episiotomy, or perineal suturing. CONCLUSION: Not only the process of childbirth itself but also processes during pregnancy seem to be strongly associated with prevalent urinary incontinence. Perineal suturing may be associated with prevalent urinary incontinence, whereas other obstetric techniques inspected do not seem to be so. PMID- 9949752 TI - Errors in gestational age: evidence of bleeding early in pregnancy. AB - OBJECTIVES: This study explored the extent of errors in gestational age as ascertained by last menstrual period. METHODS: More than 1.5 million birth records (covering the years 1967-1994) from the population-based Medical Birth Registry of Norway were used to study variation in gestational age within strata of birthweight. RESULTS: Within 100-g strata of birthweight, it was found that the observed gestational age distribution could be divided into 3 distinct underlying distributions separated by approximately 4 weeks. This pattern was present through all birthweight strata, from 200 g up to 4700 g. In addition, the apparent misclassification causing a gestational age 4 weeks too short was much more common among low-birthweight births than among heavier births. CONCLUSIONS: The separation of the gestational age distributions by intervals of close to 4 weeks suggests that errors in gestational age measurements are caused by factors related to menstrual bleeding. Furthermore, there is evidence for a strong relation between bleeding at the time of the next menstrual period after conception and low birthweight. This conclusion should be approached with caution because of the retrospective nature of the data. PMID- 9949753 TI - Acculturation and breast cancer screening among Hispanic women in New York City. AB - OBJECTIVES: This study investigated whether acculturation was associated with the receipt of clinical breast examinations and mammograms among Colombian, Ecuadorian, Dominican, and Puerto Rican women aged 18 to 74 years in New York City in 1992. METHODS: A bilingual, targeted, random-digit-dialed telephone survey was conducted among 908 Hispanic women from a population-based quota sample. Outcome measures included ever and recent use of clinical breast examinations and mammograms. Multivariate logistic regression models were used to assess the effect of acculturation on screening use. RESULTS: When demographic, socioeconomic, and health system characteristics and cancer attitudes and beliefs were controlled for, women who were more acculturated had significantly higher odds of ever and recently receiving a clinical breast examination (P < or = .01) and of ever (P < or = .01) and recently (P < or = .05) receiving a mammogram than did less acculturated women. For all screening measures, there was a linear increase in the adjusted probability of being screened as a function of acculturation. CONCLUSIONS: Neighborhood and health system interventions to increase screening among Hispanic women should target the less acculturated. PMID- 9949754 TI - Smokeless tobacco cessation intervention for college athletes: results after 1 year. AB - OBJECTIVES: The purpose of this study was to determine the efficacy of a college based smokeless tobacco cessation intervention targeting college athletes. METHODS: Sixteen colleges were matched for prevalence of smokeless tobacco use in their combined baseball and football teams and randomly assigned within college pairs to the intervention or the control group. One-year prevalence of cessation among smokeless tobacco users was determined by self-report of abstinence for the previous 30 days. Differences between groups were analyzed in a weighted version of the Fisher 1-sided permutation test for paired samples after adjustment for significant predictors of quitting other than the intervention (i.e., smokeless tobacco uses per week and most frequently used brand). RESULTS: Cessation prevalences were 35% in the intervention colleges and 16% in the control colleges when subjects with unknown quit status were defined as nonquitters. After adjustment for other significant predictors of quitting, the difference of 19% increased to 21%. The intervention effect increased with level of smokeless tobacco use. CONCLUSIONS: This intervention was effective in promoting smokeless tobacco cessation, especially among those who were more frequent users. PMID- 9949755 TI - Community measures of low-fat milk consumption: comparing store shelves with households. AB - OBJECTIVES: This study examined the relationship between the proportion of milk in food stores that is low-fat and consumption of low-fat milk in the community. METHODS: Data were gathered from 503 stores across 53 New York State zip codes. In 19 zip codes, a telephone survey measured household low-fat milk use. Census data were obtained to examine sociodemographic predictors of the percentage of low-fat milk in stores. RESULTS: The proportion of low-fat milk in stores was directly related to low-fat milk consumption in households and to the median income and urban level of the zip code. CONCLUSIONS: These results support using food store shelf-space observations to estimate low-fat milk consumption. PMID- 9949756 TI - Predictors of injury among adult recreational in-line skaters: a multicity study. AB - OBJECTIVES: This study examined risk factors for injury, injury prevalence, safety gear use, and skating habits of adult recreational in-line skaters. METHODS: Randomly selected in-line skaters in 6 major US cities were interviewed. RESULTS: Only 6% of skaters consistently wore all 4 recommended types of safety gear. Skaters with greater skating experience were more likely to perform tricks, wear less safety gear, and sustain an injury. CONCLUSION: More experienced adult recreational in-line skaters are at increased risk for injury. Safety gear use in alarmingly low in adult recreational in-line skaters, especially experienced skaters. Safe skating education programs should consider targeting this newly recognized at-risk skating population. PMID- 9949757 TI - Wife abuse among women of childbearing age in Nicaragua. AB - OBJECTIVES: This study measured the prevalence, frequency, and severity of physical wife abuse and its risk factors in Leon, Nicaragua. METHODS: A cross sectional survey was conducted with a representative sample of 488 women 15 to 49 years of age. RESULTS: The lifetime prevalence of spousal violence was 52% among ever-married women (n = 360). Spousal violence was significantly positively associated with poverty, parity, urban residence, and history of violence in the husband's family. No significant associations were found between spousal violence and women's age, education, marital dependency, or occupation. CONCLUSIONS: Wife abuse constitutes a major public health problem in Nicaragua, requiring urgent measures for prevention and treatment for victims. PMID- 9949758 TI - The influence of race on approaching families for organ donation and their decision to donate. AB - OBJECTIVES: This study examined whether patients' race was associated with their families' being approached for organ donation and agreeing to donation. METHODS: Logistic regression models were applied to data collected from records at 112 hospitals. RESULTS: The odds that a family of a White patient was approached for donation were nearly twice those for a family of an African American. The odds of donation also differed by race, but the magnitude varied by patient and hospital characteristics. CONCLUSIONS: Much attention directed toward racial disparity in donation has focused on attitudes of the public. The behavior of hospital staff also may be related to differences in rates. PMID- 9949759 TI - From socialist principles to motorcycle maintenance: the origin and development of the salaried physician model in the Israeli Public Health Services, 1918 to 1998. AB - For more than 70 years, physicians in the Israeli health care system have been employed on a fixed salary rather than on a fee-for-service basis. The present report is a brief review of the origin and development of this unique salaried physician model and its effect on the terms of physicians' employment. Archival documents were reviewed. The salaried physician model was introduced to ensure egalitarian health care for patients rather than equal payment for physicians. It was accepted by physicians because it guaranteed their employment and income. However, over the years, the salaried physician model has evolved into a complex wage scale, with multiple fringe benefits that bypass formal agreements in order to reward individual physicians. In addition, the salaried physician model has encouraged illegal private practice, which is viewed today as one of the major problems of the Israeli Public Health Services. PMID- 9949760 TI - Mammography screening. PMID- 9949761 TI - Ethics and HIV trials. PMID- 9949762 TI - Celecoxib for arthritis. PMID- 9949763 TI - Drugs for chronic heart failure. PMID- 9949764 TI - Structure-mutation analysis of the ATPase site of Dictyostelium discoideum myosin II. AB - Three loop structures called the P-loop, switch I loop and switch II loop of myosin are major components of its ATPase site, and share structural and functional homology with the loop structures in other ATPases and GTPases such as kinesin and G-protein. Using the alanine scanning mutagenesis, structure-function relationship of the switch I and switch II loops in Dictyostelium myosin II was examined. Based on crystal structures of Dictyostelium myosin motor domain, functions of each residue in those loops are discussed. PMID- 9949765 TI - The structural study of membrane proteins by electron crystallography. AB - A high-resolution electron cryo-microscope equipped with a top-entry specimen stage has been refined by modifying a previously described superfluid helium stage. Instruments equipped with such a cryo-stage achieve a resolution of better than 2.0 A and have proved extremely powerful in the high-resolution structure analysis of membrane proteins. Improvement of the electron microscopic system in combination with improved specimen preparation techniques allowed the structure of bR to be analyzed to a resolution of 3.0 A. The 3D structure of bR, especially the surface features, revealed the structural basis for the efficient guidance of protons to the entrance of the transmembrane channel. Based on the characteristic difference of the atomic scattering factors for electrons of ionized atoms versus neutral atoms as well as the data analysis, charged and uncharged amino acid residues could be discriminated. Thus, electron crystallography is providing us with new and exciting insights into the structure of membrane proteins because it not only enables us to determine the structure of a membrane protein, but allows us to study its interaction with the surrounding lipid molecules and to determine its ionization state. PMID- 9949766 TI - Neural systems for control of voluntary action--a hypothesis. AB - Action is the means by which we and animals survive. It consists of a complex combination of movements which are either innately endowed or acquired by learning. In this article, I propose a hypothesis on the relationship between the organization of action and the organization of the brain. Innate and learned actions are controlled by different levels of neural networks: innate actions are controlled by reflex mechanisms and pattern generators in the spinal cord and brainstem, while learned actions are controlled by the cerebral cortex, basal ganglia, and cerebellum. However, these mechanisms are by no means independent. Phylogenetically, animals have acquired progressively more complex actions by gaining neural connections between different neural mechanisms. This is accomplished by the connection from newly evolving brain structures, particularly the cerebral cortex, to reflex or pattern generator mechanisms, as typically observed in the neural mechanism for saccadic eye movement. The cerebral cortex is a general purpose device which can be used in different ways depending on biological demands; in other words, it is used for learned actions. In consequence, a given movement (e.g., saccade) can be produced by different neural circuits, all converging onto the movement generation mechanism (e.g., s.c.) in an excitatory manner. However, such converging inputs that promote actions are likely to produce a chaotic explosion of neural signals. There must be some way to prevent the explosion and select signals that are most appropriate for the current behavioral context. The basal ganglia system evolved to accomplish this goal. It exerts a powerful inhibition on its targets in the brainstem (e.g., s.c.) and the thalamo-cortical system, thereby closing the gate for the action promoting excitatory inputs; it also removes the sustained inhibition using another inhibition originating in the striatum (input structure of the basal ganglia), thereby opening the gate so that an appropriate action is executed. There are at least two additional functions of the basal ganglia. First, the selection mechanism of the basal ganglia is used also for the selection of simulated actions (e.g., thoughts) which are largely controlled by the association cortices. Second, it is used for learning of behavioral procedures: various kinds of signals from the cerebral cortex converge onto neurons in the basal ganglia to generate temporary association of neural signals, whose behavioral significance is evaluated by signals from the limbic system via dopaminergic neurons. The procedural memories thus created (perhaps in the cerebral cortex, particularly premotor cortices) are then used to guide learning of individual movements in which the cerebellum plays a crucial role. Thus, the implementation of learned actions is carried out by two distinct neural systems, each forming a loop circuit: 1) cerebral cortex and basal ganglia; 2) cerebral cortex and cerebellum. Although these neural systems are independent structurally, they work in parallel and cooperatively to acquire and execute learned procedures (actions). PMID- 9949767 TI - The neuronal basis of visual memory and imagery in the primate: a neurophysiological approach. AB - To understand the biological basis of memory is one of the most exciting frontiers of science. Single unit recording is a powerful method to investigate neuronal correlates of various brain functions such as memory in awake animals. Anatomical, neuropsychological, and neurophysiological evidence indicates that the IT has an important role not only for synthesizing the analyzed visual attribute into a unique configuration, but also for the storehouse of visual memory in humans and primates. We performed single unit recordings in the primate IT, and found neuronal correlates of visual long-term memory: the IT neurons could reflect learned associative relations among stimuli. The findings reviewed here support the hypothesis that the IT is a region of the brain where visual perception meets memory and imagery. PMID- 9949768 TI - Design of protein function by physical perturbation method. AB - Based on three-dimensional structure of proteins, a rational strategy to design the protein function by physical perturbation method was proposed and tested on one of the well-examined enzymes, thermolysin for higher catalytic activity. An attempt was made to change the electrostatic potential and the dynamic property of three-dimensional structure around the active sites by single-amino-acid mutations, and the physical property of the mutants was then evaluated. Several mutants were found to have remarkably higher enzymatic activity than wild type. The multiple mutation was introduced and the logarithm of the activity was found to be almost additive. A ten times higher active mutant was realized by simultaneously introducing three single-mutations. This strategy can be easily extended to not only other enzymes but also other kinds of proteins than enzymes to modify or control the protein function based on their three-dimensional structures. PMID- 9949769 TI - In memoriam Frank Morrell 1926-1996. PMID- 9949770 TI - Brain stimulation combined with electrocorticography in the surgery of epilepsy: historical highlights. PMID- 9949771 TI - Electrocorticography. Historical comments on its development and the evolution of its practical applications. PMID- 9949772 TI - Role of ECoG in 'en bloc' temporal lobe resection: the Maudsley experience. PMID- 9949773 TI - Role of the ECoG in tailored temporal lobe resection: the University of Washington experience. PMID- 9949774 TI - ECoG findings in extratemporal epilepsy: the MNI experience. PMID- 9949775 TI - Chronic electrocorticography: Cleveland clinic experience. PMID- 9949776 TI - Pharmacological activation. AB - Despite the disparate results in clinical studies a few conclusions can be made. Pharmacologic activation during ECoG serves a minor role in determining the limits of a cortical excision during surgical treatment for intractable partial epilepsy. The extensive preoperative evaluation including long-term EEG monitoring to assess the electroclinical correlation and MRI are of primary importance. There is sufficient information at some epilepsy centers demonstrating a putative beneficial effect of ECoG that its continued use can be justified. Pharmacologic activation of epileptiform discharges is never preferred to spontaneous alterations occurring in the pre-excision ECoG. It would seem reasonable to consider pharmacologic activation at the time of the pre-excision ECoG if no discharges are present. Further studies will be needed to decide on the 'drug of choice', but for now methohexital would be most reasonable given the enormous amount of information regarding its induction properties. One must keep in mind the clear limitations associated with the use of these drugs especially the possibility of 'misleading' informations as documented by Fiol et al. (1990). The use of post-excision ECoG in general is sufficiently dubious that the practice of pharmacologic activation during this recording cannot be recommended. Perhaps the most reasonable view of pharmacologic activation is the position articulated by our Dr. Norman So (1995): 'There are many who advocate the injection of a short-acting barbiturate like methohexital to activate spiking during ECoG, but given the difficulty already encountered in interpreting the spontaneous ECoG it seems foolhardy to complicate the picture with potentially non-specific drug effects'. PMID- 9949777 TI - The significance of electrocorticographic findings in focal cortical dysplasia: a review of their clinical, electrophysiological and neurochemical characteristics. PMID- 9949778 TI - Post-excision residual spiking after frontal lobe removal: outcome. PMID- 9949779 TI - Increased neocortical spiking and surgical outcome after selective amygdalo hippocampectomy. PMID- 9949780 TI - Direct intraoperative recordings from the hippocampal formation: relation with quantitative volumetric MRI. PMID- 9949781 TI - Correlation between mesial temporal and temporal neocortical interictal spiking in acute ECoG and chronic depth electrode recordings. PMID- 9949782 TI - ECoG findings in hemispherectomy. PMID- 9949783 TI - Applications of image-guided surgery to intraoperative electrophysiology. PMID- 9949784 TI - Alcohol and cardiovascular diseases: a historical overview. AB - Evident disparities in relationships make it desirable to consider several disorders separately. (1) Alcoholic cardiomyopathy was perceived 150 years ago, but understanding was clouded by recognition of beriberi and of synergistic toxicity from alcohol with arsenic or cobalt. (2) A report of a link between heavy drinking and hypertension in WWI French soldiers was apparently ignored for > 50 years. Epidemiological and intervention studies have now firmly established this association, but a mechanism remains elusive. (3) The 'holiday heart syndrome', an increased risk of supraventricular tachyarrhythmias in alcoholics, has been widely known to clinicians for 25 years; data remain sparse about the total role of heavier drinking in cardiac rhythm disturbances. (4) Failure of earlier studies to distinguish types of stroke impeded understanding; it now seems probable that alcohol drinking increases risk of haemorrhagic stroke but lowers risk of ischaemic stroke. (5) Heberden reported angina relief by alcohol in 1786, and an inverse alcohol-atherosclerosis association was observed by pathologists early in this century. Recent population studies and plausible mechanisms support a protective effect of alcohol against coronary disease. International comparisons dating back to 1819 suggest beverage choice as a factor, but this issue (the 'French Paradox') remains unresolved. PMID- 9949785 TI - Metabolic consequences of alcohol ingestion. AB - Many of the pathophysiological effects of alcohol ingestion relate to the pathways of ethanol metabolism. However, some of the acute and chronic effects of ethanol use are also attributable to the direct effects of ethanol, e.g. on membrane fluidity. Oxidation of ethanol to acetaldehyde is catalysed by alcohol dehydrogenase (ADH). There are at least six classes of ADH, some of which show inter-individual variation, i.e. genetic polymorphism, that influences the rate of ethanol oxidation. A consequence of ethanol oxidation is an increase in the NADH/NAD redox potential within the cytosol and mitochondria with subsequent alteration in several tissue metabolites. The popular hypothesis that most, if not all, of the consequences of chronic alcohol ingestion can be explained by these redox changes is still unproven. This should be considered in the context that most metabolic pathways of the liver are affected by alcohol, as are several endocrine axes in the whole body. In fact most, if not all, tissues and organs are deleteriously affected by chronic ingestion. Acetaldehyde, the product of ethanol oxidation, is chemically highly reactive, toxic and immunogenic. However, the concentrations achieved in vivo usually fall short of those used to produce these toxic effects in experimental situations. Oxidation of acetaldehyde is also coupled to redox changes, although primarily affecting the intra-mitochondrial redox. In addition, further oxidative pathways of ethanol metabolism can lead to the formation of fatty acid ethyl esters, hydroxyethyl free radicals and reactive oxygen species via the ethanol-specific cytochrome P450-2E1 system. There is no conclusive evidence that nutrient supplementation has beneficial effects on overall ethanol-mediated tissue damage. PMID- 9949786 TI - Alcohol and the myocardium. AB - Structural and functional abnormalities are prominent in alcoholic cardiomyopathy (ACM). Histological features in affected subjects are almost identical to the characteristics of dilated cardiomyopathy. Quantitative morphometry, however, can distinguish between ACM and dilated cardiomyopathy. Biopsies from patients with ACM show increases in the activities of some myocardial enzymes (alpha hydroxybutyric dehydrogenase, creatine kinase, lactate dehydrogenase, malic dehydrogenase) which are correlated with the bimodal distribution of alcohol intake and may represent an adaptive response. One-third of patients with ACM have serum antibodies against cardiac acetaldehyde-protein adducts. Animal models of ethanol toxicity have shown that acutely, alcohol and acetaldehyde reduce the synthesis of cardiac contractile proteins in vivo. Two-dimensional SDS-PAGE has also shown that in rats chronically fed alcohol, the relative amounts of over 10% of heart muscle proteins are altered. The heat shock proteins (HSP) Hsp60 and Hsp70 are decreased in alcohol-fed rats, as is desmin. Reduction in HSPs may indicate reduced myocardial protection whilst a fall in desmin may indicate structural defects. In conclusion, ACM is a complex process that is due to altered protein synthesis, the formation of acetaldehyde adducts and a reduction of cardiac HSPs and desmin. Both acetaldehyde and alcohol are myocardial perturbants. PMID- 9949787 TI - Alcohol, free radicals and antioxidants. AB - Antioxidants in alcoholic beverages, especially polyphenolic compounds in red wine, have been proposed as an important contributory factor to the protective effect of regular alcohol use against atherosclerotic cardiovascular disease. The postulated mechanism involves quenching of free radicals with decreased oxidative damage to low density lipoprotein (LDL) hence reducing its potential atherogenicity. There is definitive in vitro evidence that extracts of red wine, white wine, grape juice and beer can inhibit the oxidation of LDL, the degree of inhibition being directly proportional to beverage polyphenolic content and able to be abolished by prior stripping of the polyphenolics from the alcoholic beverage. These in vitro antioxidant effects have not been reliably reproduced in vivo after acute or short-term administration of alcoholic beverages. In fact, in some studies where white wine or beer have been given over 2-4 week periods, enhanced oxidizability of LDL cholesterol has been reported. Such findings are consistent with the possibility that, depending on the beverage, a predominant pro-oxidant effect of alcohol itself may outweigh any antioxidant effect of beverage polyphenolics. Increased oxidant stress and enhanced lipid peroxidation with alcohol have several biologically plausible explanations and have been reported as possible mechanisms for alcohol-related toxicity and injury in various tissues. Therefore, before the promotion of any particular benefits of ingestion of polyphenolics from alcoholic beverages (especially red wine) for prevention of atherosclerotic cardiovascular disease, the balance of redox effects in vivo will need careful further clinical and laboratory evaluation. PMID- 9949788 TI - Alcohol, cardiac arrhythmias and sudden death. AB - Studies in experimental animals have shown varying and apparently opposite effects of alcohol on cardiac rhythm and conduction. Given acutely to non alcoholic animals, ethanol may even have anti-arrhythmic properties whereas chronic administration clearly increases the animals' susceptibility to cardiac arrhythmias. Chronic heavy alcohol use has been incriminated in the genesis of cardiac arrhythmias in humans. The evidence has come from clinical observations, retrospective case-control studies, controlled studies of consecutive admissions for arrhythmias, and prospective epidemiological investigations. Furthermore, electrophysiological studies have shown that acute alcohol administration facilitates the induction of tachyarrhythmias in selected heavy drinkers. The role of alcohol appears particularly conspicuous in idiopathic atrial fibrillation. Occasionally, ventricular tachyarrhythmias have also been provoked by alcohol intake. Several lines of evidence suggest that heavy drinking increases the risk of sudden cardiac death with fatal arrhythmia as the most likely mechanism. According to epidemiological studies this effect appears most prominent in middle-aged men and is only partly explained by confounding traits such as smoking and social class. The basic arrhythmogenic effects of alcohol are still insufficiently delineated. Subclinical heart muscle injury from chronic heavy use may be instrumental in producing patchy delays in conduction. The hyperadrenergic state of drinking and withdrawal may also contribute, as may electrolyte abnormalities, impaired vagal heart rate control, repolarization abnormalities with prolonged QT intervals and worsening of myocardial ischaemia or sleep apnoea. Most of what we know about alcohol and arrhythmias relates to heavy drinking. The effect of social drinking on clinical arrhythmias in non alcoholic cardiac patients needs to be addressed further. PMID- 9949789 TI - Alcohol intake, lipids and risks of myocardial infarction. AB - The health effects of alcohol consumption remain complex for several reasons: the risks and benefits accrue over many years, assessment of drinking is generally based on self-report, drinking habits change over time and studies estimate average daily drinking disregarding how or when the beverage was consumed. In addition, alcohol consumption is associated with lifestyle factors which may confound relationship with disease. Despite these methodological difficulties, epidemiological studies are surprisingly consistent, showing that light to moderate intake is associated with a lower risk of total mortality compared with those who drink heavily or do not drink at all. Thus there is a J-shaped association of alcohol intake with risk of total mortality whose basis is likely to be the effect of summing the cause-specific effects at the various drinking levels. Studies using a diversity of methods and populations have consistently reported an inverse relationship between coronary heart disease and light to moderate drinking, with the depth and width of the J-shaped mortality curve depending on the underlying risk of coronary heart disease for that population. The higher risk of death at heavy drinking levels is due to increased risk of cancer, liver diseases, cardiomyopathy and stroke. The precise mechanisms behind these effects of alcohol are only now beginning to be understood. The most plausible mechanism by which alcohol reduces the risk of coronary heart disease is by its effects on blood lipids, particularly increases in high density lipoprotein (HDL) cholesterol: about 50% of the risk reduction attributable to alcohol is explained by changes in total HDL. Further support for the HDL hypothesis comes from the lack of a differential effect of alcohol by beverage type. While the association of alcohol and cardiovascular disease is likely to be causal, any public health recommendations must consider the complexity of alcohol's metabolic, physiological and psychological effects. PMID- 9949790 TI - Alcohol, coagulation and fibrinolysis. AB - Despite the solid evidence for thrombosis playing a key role in coronary heart disease (CHD) mortality, identifying specific haemostatic risk factors for CHD has been difficult except for fibrinogen. Excessive alcohol consumption clearly affects platelet function. Moderate alcohol consumption may affect several haemostatic factors, including fibrinogen concentration, platelet aggregability and the fibrinolytic factors tissue-type plasminogen activator and plasminogen activator inhibitor. These changes support the hypothesis that moderate alcohol beneficially affects the haemostatic balance in a way that decreases the risk of CHD mortality. PMID- 9949791 TI - Alcohol, blood pressure and hypertension. AB - In the last 30 years a large number of cross-sectional studies, a smaller number of prospective cohort studies and several intervention studies have addressed the alcohol-blood pressure relationship. Although a number of questions--such as the validity of measurement of alcohol intake, shape of the alcohol-blood pressure relationship, threshold dose for hypertension, and plausible pathophysiological mechanisms--have not yet been answered satisfactorily, it is clear that a causal association exists between chronic intake of > or = 30-60 g alcohol per day and blood pressure elevation in men and women. To call the alcohol-blood pressure relationship causal is justified because chance and, to a large degree, bias and confounding, have been ruled out as plausible explanations in most observational studies. More importantly, the intervention studies support the observational studies and show a remarkable consistency in demonstrating a potentially valuable decrease in blood pressure when heavy drinkers abstain or restrict their alcohol intake. From the different studies a rule of thumb can be derived: above 30 g of alcohol intake per day an increment of 10 g of alcohol per day increases on average systolic blood pressure by 1-2 mmHg and diastolic blood pressure by 1 mmHg. PMID- 9949792 TI - Do known cardiovascular risk factors mediate the effect of alcohol on cardiovascular disease? AB - The association between alcohol intake and atherosclerotic cardiovascular disease (CVD) in epidemiological studies is consistent and shows some protection from CVD at consumption levels of one to two drinks per day, but a sharp increase in CVD associated with three or more drinks per day. Analyses of potential mediators of effects of alcohol on CVD show that it increases high density lipoprotein (HDL) cholesterol levels and favourably influences thrombotic factors, especially fibrinogen, and also fibrinolytic factors. Some evidence also suggests moderate alcohol consumption may reduce insulin resistance. However, studies also show an adverse effect of alcohol, particularly at higher doses, on blood pressure (leading to hypertension) and directly on the myocardium (leading to arrhythmias and myocardiopathy). Statistical modelling of the alcohol-CVD relationship is consistent in several studies, with a protective pathway via elevated HDL cholesterol and an adverse pathway through elevated blood pressure. Other possible mediators influenced by alcohol have not yet been examined in this type of analysis. The French Paradox has led to speculation that wine is the only protective alcoholic beverage for CVD, or at least that it has a stronger effect. Multiple non-ethanol components of wine have been studied in the laboratory and have been shown to have antioxidant or anticoagulant effects. Although wine does appear more protective in ecological studies, studies within cohorts show similar effects across alcoholic beverages, suggesting confounding in ecological studies by diet, lifestyle, or other variables. The key component of alcoholic beverages thus appears to be ethanol, consistent with the known potent effects of ethanol on HDL cholesterol and thrombotic factors. The upswing in CVD risk with three or more drinks per day is sharp and emphasizes that benefit from alcohol is limited to moderate consumption only. This upswing also cautions against any public health recommendation to drink alcohol, since many persons will not or cannot limit their intake to moderate levels. PMID- 9949793 TI - The J-shaped curve and changes in drinking habit. AB - The accepted interpretation of the J-shaped curve relating alcohol intake to mortality or coronary heart disease is that the lowest point on the curve (light/moderate drinking) represents optimum exposure to alcohol and that the increased risk in non-drinkers reflects the consequence of sub-optimum exposure. However, non-drinkers, both ex-drinkers and lifelong teetotallers, consistently show an increased prevalence of conditions likely to increase morbidity and mortality compared with occasional or light drinkers. In addition, regular light drinkers tend to have characteristics extremely advantageous to health. Changes take place in alcohol intake in individuals over time, with a strong downward drift from heavy or moderate drinking towards non-drinking, affected to a considerable extent by the accumulation of ill health. Reduction in alcohol intake or giving up drinking is associated with higher rates of new diagnoses than remaining stable in alcohol intake and also with higher rates of both cardiovascular and non-cardiovascular mortality. The use of non-drinkers as a baseline, and failure or inability to adequately take into account the characteristics of subjects in the different alcohol intake categories, exaggerates the risk of coronary heart disease events and all cause mortality in non-drinkers and the benefits of light/moderate alcohol intake. PMID- 9949794 TI - Mechanisms of alcohol-related strokes. AB - Epidemiological investigations have shown a linear positive correlation between the risk of haemorrhagic stroke and level of alcohol consumption. Ischaemic stroke shows a weaker relationship, which is J-shaped, suggesting that regular light-to-moderate alcohol consumption may carry a decreased risk. Case reports and case-control studies indicate that heavy recent drinking, but not heavy former drinking, increases the risk for both types of stroke. Larger amounts of alcohol are needed to trigger aneurysmal subarachnoid haemorrhage than spontaneous intracerebral haemorrhage. The increased risk caused by recent heavy drinking may be partly due to elevated systolic blood pressure, but alcohol may also provoke cerebral arterial vasospasm, as observed in animal experiments. Alcohol-induced fluctuation in haemostatic and fibrinolytic factors has not been proved to precipitate alcohol-related strokes, but may contribute to both an increase and a decrease of the risk. Subtypes of ischaemic stroke associate differently with alcohol consumption. A recent series of patients with ischaemic brain infarction showed that of the victims having a high and medium risk for cardiogenic embolism, 50% and 45% were intoxicated, respectively. This suggests that cardiogenic embolism is a significant mechanism leading to ischaemic stroke during heavy drinking of alcohol. PMID- 9949795 TI - The French paradox and wine drinking. AB - Despite a high level of risk factors such as cholesterol, diabetes, hypertension and a high intake of saturated fat, French males display the lowest mortality rate from ischaemic heart disease and cardiovascular diseases in Western industrialized nations (36% lower than the USA and 39% lower than the UK). By contrast, mortality from all causes is only 8% lower than in the USA and 6% than in the UK, owing to a high level of cancer and violent deaths. In a recent study of 34,000 middle-aged men from Eastern France with a follow-up of 12 years we have observed that for 48 g of alcohol (mostly wine) per day as the mean intake, mortality from cardiovascular diseases was lower by 30%, all-cause mortality was reduced by 20%, but mortality by cancer and violent death was increased compared with abstainers. Thus the so-called 'French Paradox' (a low mortality rate specifically from cardiovascular diseases) may be due mainly to the regular consumption of wine. PMID- 9949796 TI - Alcohol and all-cause mortality: an overview. AB - The relationship between alcohol consumption and all-cause mortality is J-shaped in most industrialized countries. The J-shape is the result of the combination of adverse and beneficial effects of alcohol consumption. Adverse effects include several types of cancer (oropharyngeal, oesophageal, liver, laryngeal and breast cancer), other diseases of the aerodigestive tract, diseases of the heart (alcoholic cardiomyopathy, haemorrhagic stroke, arrhythmia, hypertension), addiction-related mental disorders, and accidents and injuries. Beneficial effects are for ischaemic heart disease and ischaemic stroke. The exact shape of the all-cause mortality curve in a given region depends upon the proportion of the population consuming alcohol at different levels, especially heavy consumption, and on the prevalence of the disorders named above. Thus regions with a relatively low prevalence of ischaemic cardiovascular disease show almost no benefits of consumption, and an all-cause mortality curve which is almost exponential. Females experience a minimum mortality risk at a level of alcohol intake which is lower than that associated with the minimum risk for men. Similarly, an upturn in mortality risk occurs at lower intake levels for women than for men. At present, there is no satisfactory explanation for the observation that the shape of the mortality curve varies with the consumption level of the cohort under study. Heavier-drinking cohorts tend to display their minimum risk at relatively higher levels of alcohol intake than cohorts with lower alcohol consumption. PMID- 9949797 TI - Alcohol, cardiovascular diseases and public health policy. AB - Public health policy should aim to reduce the harm done by alcohol use, whilst recognizing its real and perceived benefits. The reduced risk of coronary heart disease (CHD) with the consequent reduction of mortality for some people in older age is one such benefit. The increased risk of sudden coronary death from acute alcohol intoxication is one such harm. A number of policies have been demonstrated to be effective in the reduction of the harm done by alcohol use, at least in industrialized countries. These are: enforcement of a minimum drinking age; drink-drive deterrence; enforced prevention of intoxication in public drinking places; controls on access to alcohol, including restrictions on numbers of licensed premises and hours and days of sale; and taxation policy to regulate the affordability of alcohol. Many of these strategies seem unlikely to have a direct effect on drinking relevant for reduced risk of CHD, but are likely to have a direct beneficial effect on drinking relevant for sudden coronary death. The level of alcohol consumption associated with the lowest mortality rate for a population will vary depending on patterns of ill health and causes of death. In countries with high rates of CHD the per capita level may be in the order of about three litres of absolute alcohol per year among drinking adults. In countries with low rates of CHD, the level is likely to be substantially lower. Many countries in which alcohol is readily available are consuming at a level substantially above three litres per capita of drinking adults per year and in these countries public health policy should continue to advise action to reduce per capita consumption. PMID- 9949798 TI - Host genetic susceptibility to human tuberculosis. AB - Convincing evidence exists that host genes influence the outcome of infection in human tuberculosis. We are employing two complementary strategies to find the genes involved: a linkage-based, comprehensive genome screen and an association based candidate gene study. In a genome screen of 282 markers on 92 affected sib pairs we have found evidence of co-segregation of disease with five markers, but further studies are required to replicate these results. The absence of a single strongly linked marker demonstrates that susceptibility to human tuberculosis is not controlled by a single major gene. Using a candidate gene approach investigating over 400 tuberculosis cases and 400 ethnically matched healthy controls we have found evidence that NR AMP1 and vitamin D receptor gene (VDR) polymorphisms are associated with tuberculosis. It is hoped that by identifying the genes that account for why only a minority of those exposed to tuberculosis develop disease, we will develop new insights into potential therapeutic and preventative strategies. PMID- 9949799 TI - The epidemiology of tuberculosis in South Africa. AB - Reports by reliable observers indicate that tuberculous disease did not occur to any great extent amongst South Africa's indigenous peoples prior to European colonization. Colonization introduced sources of infection and caused rapid urbanization for purposes of commerce and trade. By the start of the 20th century tuberculosis was recognized as a common health problem amongst the Black and Coloured peoples of South Africa. National notification commenced in 1921 and an incidence of 43 per 100,000 rose to 365 per 100,000 in 1958 and declined to 162 per 100,000 in 1986 before rising again to 221 per 100,000 in 1993. High incidences have been consistently recorded amongst the Coloured population of the Western Cape Province: in 1993 713 per 100,000 compared to the national incidence of 225 per 100,000. Using a computerized geographical information system the precise distribution of tuberculosis in two adjacent underprivileged, mainly Coloured communities, with a combined population of 34,000, is being studied. From 1985 to 1994 4044 notified tuberculosis cases gave an incidence of about 1200 per 100,000, varying from 78 to 3150 per 100,000 for the 39 enumerator subdistricts used for census purposes, and was highest in those with the lowest income. Of 5345 housing units 1835 (34%) housed at least one case of tuberculosis and 483 (9%) three or more cases. IS6110 DNA fingerprinting of strains from this community has shown a high degree of strain diversity (209 out of 334 strains evaluated). Clustering, indicative of recent transmission, was found in only 30% of isolates in this high tuberculosis incidence community. PMID- 9949800 TI - Using conventional and molecular epidemiological analyses to target tuberculosis control interventions in a low incidence area. AB - To consolidate the gains made in controlling tuberculosis in industrialized countries in the past five years, we must analyse carefully the epidemiology of the disease and the effectiveness of various control interventions. In San Francisco we have performed conventional and molecular epidemiological analyses that have shown that there are in essence two parallel epidemiological patterns, one in the foreign-born population and the second among US-born persons, with little interaction between them. Most tuberculosis in the foreign-born population is a result of endogenous reactivation of latent infection, whereas recent infection with rapid progression to illness is a more frequent course in US-born cases. Among the US-born cases specific risk factors--homelessness, HIV infection, drug abuse--are highly prevalent. Although there has been a progressive reduction in the number of cases and in the proportion resulting from recent infection in San Francisco in the past five years, there continues to be a high proportion of cases that result from recent infection among US-born persons. These findings suggest that existing control interventions should be tailored to specific target groups and that new interventions are needed to provide for increased efficacy. PMID- 9949801 TI - Vaccines, genes and trials. AB - This symposium takes place at the intersection of an acute success (the extraordinary recent developments in genetical research relevant to mycobacteria) and a chronic failure (the embarrassing failure of Bacillus Calmette-Guerin [BCG], the world's most widely used vaccine, to control tuberculosis). I will summarize the arguments that the variable efficacy of BCG is attributable, at least in part, to genetic differences in either the vaccine, the host populations or Mycobacterium tuberculosis. I will then address the problem of building upon our experience with BCG in order to develop and evaluate an improved vaccine against tuberculosis. The fact that the great burden of tuberculosis is associated with pulmonary disease in adults, much of which is associated either with reactivation of old infection or else with relatively recent reinfection, poses an immense problem for vaccine strategy and evaluation. One approach may be to vaccinate early in life, prior to initial infection with the tubercle bacillus, and then to follow up individuals for many decades. The alternative is to develop vaccines to boost appropriate protective immune mechanisms in individuals who have already been infected, and/or who have already been vaccinated (e.g. with BCG), and/or who may also have been sensitized to various environmental mycobacteria that influence the immune response to tubercle bacilli. The latter approach is novel, and may ultimately prove impossible, but its potential logistic and public health advantages are so great that it warrants serious attention by the research community before being abandoned. PMID- 9949802 TI - Immunological and endocrinological characteristics of tuberculosis that provide opportunities for immunotherapeutic intervention. AB - Immunity to tuberculosis requires a T helper 1 (Th1) response which can be compromised by excessive release of inflammatory cytokines or Th2 activity. Environmental saprophytes can protect against tuberculosis by inducing Th1 recognition of the common antigens, or make mice more susceptible to tuberculosis than unimmunized controls by evoking a Th2 response. A mixed Th1 + Th2 response increases the local toxicity of tumour necrosis factor alpha (TNF-alpha). Some saprophytes are potent immunogens. A killed preparation of Mycobacterium vaccae can cause systemic activation of spontaneously Th1 cytokine-secreting cells in humans, and can non-specifically suppress pre-existing IgE formation and interleukin 5 (IL-5) production in murine models of allergy. These effects, and the Th2-inducing effects of other species, may explain the variable efficacy of Bacillus Calmette-Guerin, and suggest the need for new approaches to the screening of vaccines before trial in humans. The balance of Th1 to Th2 and the function of inflammatory cytokines are also regulated by cortisol. Glucocorticoid metabolism is abnormal in tuberculosis, suggesting overactivity of 11-beta hydroxysteroid reductase enzymes. The reductase activity of these enzymes is enhanced by TNF-alpha and IL-1 beta. The roles of Th2, inflammatory cytokines, common antigens and changes in cortisol metabolism suggest several strategies for immunotherapy, and several sites where genetic polymorphisms may affect susceptibility. PMID- 9949803 TI - Recombinant interleukin 2 adjunctive therapy in multidrug-resistant tuberculosis. AB - Multidrug-resistant tuberculosis patients respond poorly to antituberculosis therapy and therefore require new modalities of treatment to overcome the infection. Administration of low dose recombinant human interleukin 2 (rhuIL-2) in combination with chemotherapy to multidrug-resistant tuberculosis patients resulted in reduced or cleared sputum acid-fast bacilli in about 60% of the patients in association with enhanced activation of the immune system. Daily rhuIL-2 administration for 30 days induced increases in CD25+ and CD56+ cells in the blood. rhuIL-2 therapy also resulted in increased expression of gamma interferon and IL-2 mRNA at the site of a delayed-type hypersensitivity (DTH) response to purified protein derivative of tuberculin. Differential display reverse transcriptase PCR revealed several genes expressed at the DTH skin test site that were up- or down-regulated during rhuIL-2 treatment. The differentially regulated genes included components of endocytic vacuoles, enzymes of the respiratory pathway and other regulators of cellular function. The physiological importance of the differential expression of these genes is under investigation to determine their roles in leukocyte activation and in the development of an antimycobacterial response. PMID- 9949804 TI - Cellular and genetic mechanisms underlying susceptibility of animal models to tuberculosis infection. AB - I shall propose a new working hypothesis regarding the immunopathogenesis of tuberculosis infections in the mouse and guinea-pig models of pulmonary disease which differs from the current dogma that the development of caseous and potentially liquefied lesions in the susceptible guinea-pig lung is due to excessive expression of delayed-type hypersensitivity. I intend to show that the mouse is resistant because T cells entering the granulomatous lesions create highly organized wedges into the epithelioid macrophage fields, thus potentially saturating the tissues with cytokines. Where local necrosis does occur, it is contained by an efficient fibrotic response. In the guinea-pig, however, T cells remain in a peripheral mantle and do not invade the lesion. As a result, central macrophages are not activated, allowing bacterial growth and destructive caseation. I will describe data from the mouse system which show that certain mouse strains (C57BL/6, C5BL/10) are highly resistant to aerosol challenge, whereas other strains (DBA/2, AKR, CBA) are less so. These latter strains initially control the infection, but are subject to reactivation disease 50-200 days later. The histological data so far tend to support the hypothesis that these strains only induce acquired immunity during the reactivation phase, and upon initial exposure rely mainly on innate immunity to control the infection. This may be an important factor underlying the onset of reactivation disease in humans. PMID- 9949805 TI - Susceptibility to tuberculosis as a complex genetic trait: analysis using recombinant congenic strains of mice. AB - Previous advances in the genetics of infectious diseases derived principally from identification of single genes and their isolated effects on the progression of infection. Modern genetic analysis represents a powerful means of understanding the interplay among different pathways activated in the course of infection, their hierarchy and interactions in terms of the development of an optimal protective strategy. By utilizing both whole-genome scanning of (C3HxC57BL/6)F2 and a set of the recombinant congenic strains, produced by backcrossing B10 onto a C3H background, we demonstrated that susceptibility to tuberculosis is a multigenic trait. We have identified two distinct groups of susceptible mice: one that dies within four to six weeks of infection (supersusceptible) and another that dies within seven to 10 weeks (comparable to the susceptible parental strain). Our preliminary genetic analysis suggests that the susceptibilty of those groups is controlled by different genetic factors. Supersusceptible mice exhibit dramatic lung pathology, not observed in either parental strain, and their survival after infection with virulent Mycobacterium tuberculosis is comparable to that of mice rendered immunodeficient by disruption of essential immune genes. Further genetic and functional analyses of these strains offer possibilities for understanding the control of transmission, preferential growth of the pathogen in the lung, and mechanisms of local and systemic protective immune responses. PMID- 9949806 TI - Signals that regulate the host response to Mycobacterium tuberculosis. AB - An appropriate T helper (Th) 1 immune response is required for the elimination of Mycobacterium tuberculosis. The factors regulating the polarization of mouse or human T cells to produce Th1 or Th2 cytokines are briefly reviewed. These factors include host genetics, cytokines present at the site of T cell activation, the type, dose and localization of antigen, the type of antigen-presenting cells, the engagement of different costimulatory molecules, steroid hormones and age. T cells of children produce low levels of gamma-interferon and we hypothesize that this may partly explain the differences in the clinical manifestations of tuberculosis in children and adults. Given that Th2 cytokines inhibit Th1 responses, the question arises of whether individuals mounting prominent Th2 responses, manifested by high serum IgE levels, are more susceptible to M. tuberculosis. In a community with a high incidence of tuberculosis, serum IgF levels, a marker of prominent Th2 responses, correlate with disease incidence and with socioeconomic deprivation. We propose that Th2 immune dominance, probably induced by intestinal parasites, enhances susceptibility to tuberculosis. Furthermore, our finding that serum IgE declines in patients following active tuberculosis argues that tuberculosis down-regulates Th2 responses. PMID- 9949807 TI - Analysis of the genome of Mycobacterium tuberculosis H37Rv. AB - The powerful combination of genomics and bioinformatics is providing a wealth of information about Mycobacterium tuberculosis, the aetiological agent of human tuberculosis, that will facilitate the conception and development of new therapies. The starting point for genome sequencing was the integrated map of the 4.4 Mb circular chromosome of the widely used, virulent reference strain, M. tuberculosis H37Rv. Cosmids and bacterial artificial chromosomes were selected from ordered libraries and subjected to systematic shotgun sequence analysis. This approach simplified sequence assembly as the genome is rich in repetitive DNA. In common with most bacteria, > 90% of the potential coding capacity is used, and probable or tentative functions could be attributed to > 70% of the genes. The potential biological roles of two of the principal driving forces in genome dynamics, insertion sequence elements and polymorphic multigene families are discussed. PMID- 9949808 TI - Bacterial genetics and strain variation. AB - An entire genome sequence will provide valuable information, but the genome of only one individual will limit interpretation of that information. Knowledge concerning genome variation in both eukaryotic and prokaryotic organisms such as Mycobacterium tuberculosis is likely to yield information of equal value and provide fundamental insights concerning the function of the genome. The variability in the genome between individual strains may be small and well defined, but it may cause large phenotypic changes (e.g. point mutations causing drug resistance). Clinical and epidemiological observations have led to the development of hypotheses, assumptions and models concerning disease dynamics. However, genome variation studied by molecular epidemiology has made new insights possible, which have allowed us to examine prevailing dogmas concerning tuberculosis. Recent results suggest that historical dogmas may well hold true in some communities, but not all. The information gathered from studying strain variation can be used for modelling disease dynamics, prediction of epidemics, policy planning and for monitoring the outcome of new interventions, as well as for gaining insight into the life processes of the organism. However, molecular epidemiology has its own limitations, some of which result from our lack of understanding of genome variation. We need further information in order to understand clonality and evolution of this organism so that our use of molecular tools in epidemiology and drug development may become more relevant and accurate. PMID- 9949809 TI - Antibiotic resistance in mycobacteria. AB - Multiple drug resistance in mycobacteria compromises the use of antibiotics. Although the genetic and biochemical bases of antibiotic resistance in mycobacteria are largely understood, a number of questions remain to be addressed. This chapter discusses the potential roles of hypermutability and compensatory mutations in establishing stable resistant phenotypes in the pathogenic mycobacteria. PMID- 9949810 TI - Mechanisms for isoniazid action and resistance. AB - Isoniazid is the most widely used antituberculosis drug. Genetic studies in Mycobacterium smegmatis identified the inhA-encoded, NADH-dependent enoyl acyl carrier protein reductase as the primary target for this drug. A reactive form of isoniazid inhibits InhA by reacting with the NAD(H) cofactor bound to the enzyme active site forming a covalent adduct (isonicotinic acyl NADH) that is apt to bind with high affinity. Resistance can occur by increased expression of InhA or by mutations that lower the enzyme's affinity to NADH. Both of these resistance mechanisms are observed in 30% of clinical tuberculosis isolates. Mutation in katG, which encodes catalase peroxidase, is the most common source for resistance. Another mechanism for isoniazid resistance, in M. smegmatis, occurs by defects in NADH dehydrogenase (Ndh) of the respiratory chain. Genetic data indicated that ndh mutations confer resistance by lowering the rate of NADH oxidation and increasing the intracellular NADH/NAD+ ratio. An increased amount of NADH may prevent formation of isonicotinic acyl NADH or may promote displacement of the isonicotinic acyl NADH from InhA. While our studies have identified this mechanism in M. smegmatis, results reported in early literature lead us to believe that it can occur in Mycobacterium tuberculosis. PMID- 9949811 TI - The impact of genomics on the search for novel tuberculosis drugs. AB - The emergence of multidrug-resistant strains of Mycobacterium tuberculosis has highlighted the need for new drugs to treat tuberculosis. Drugs that either shorten the overall duration of therapy or that simplify the regimen would significantly improve compliance and hence reduce treatment failure rates. The drug development process begins with identification and validation of specific targets. These may be relevant for inhibiting growth of the bacterium in vitro, and hence yield novel bactericidal agents, or they may be required at other stages of growth, such as survival in host macrophages. With the availability of the complete genome sequence of M. tuberculosis, the primary sequence of every drug target in the pathogen is known. A combination of approaches is being employed to exploit the information contained in the genome and thereafter to identify lead compounds that may yield new drugs. PMID- 9949813 TI - Grasping an object: one movement, several components. AB - The visuomotor transformations for producing a grasping movement imply simultaneous control of different visual mechanisms. The object size, orientation and 3D characteristics have to be encoded for the selection of the appropriate opposition space, within which the opposition forces will be applied on the object surface. These mechanisms also have to combine with those of the transport of the hand to the object location. Finally, biomechanical constraints impose categorical visuomotor decisions for positioning the opposition space according to object changes in size, orientation and spatial location. This paper examines possible interactions between the specialized structures for visuomotor transformation and the internal model that adapts prehension to its goals. PMID- 9949812 TI - DNA vaccines against tuberculosis. AB - DNA plasmids encoding Mycobacterium tuberculosis antigen 85 (Ag85) were tested as vaccines in animal models. Ag85 DNA induced relevant immune responses (i.e. T helper (Th) cells, Th1 cytokines and cytotoxic T lymphocytes) and was protective in mouse and guinea pig models of mycobacterial disease. Therefore, DNA vaccination holds promise as an effective means of preventing tuberculosis in humans. Furthermore, this technique is amenable to identifying the protective antigens of M. tuberculosis. PMID- 9949814 TI - Vision for perception and vision for action in the primate brain. AB - Visual systems first evolved not to enable animals to see, but to provide distal sensory control of their movements. Vision as 'sight' is a relative newcomer to the evolutionary landscape, but its emergence has enabled animals to carry out complex cognitive operations on perceptual representations of the world. The two streams of visual processing that have been identified in the primate cerebral cortex are a reflection of these two functions of vision. The dorsal 'action' stream projecting from primary visual cortex to the posterior parietal cortex provides flexible control of more ancient subcortical visuomotor modules for the production of motor acts. The ventral 'perceptual' stream projecting from the primary visual cortex to the temporal lobe provides the rich and detailed representation of the world required for cognitive operations. Both streams process information about the structure of objects and about their spatial locations--and both are subject to the modulatory influences of attention. Each stream, however, uses visual information in different ways. Transformations carried out in the ventral stream permit the formation of perceptual representations that embody the enduring characteristics of objects and their relations; those carried out in the dorsal stream which utilize moment-to-moment information about objects within egocentric frames of reference, mediate the control of skilled actions. Both streams work together in the production of goal directed behaviour. PMID- 9949815 TI - Sensory input and control of grip. AB - When we use our digits to manipulate objects the applied fingertip forces and torques tangential to the grip surfaces are a result of complex muscle activity. These patterns are acquired during our ontogenetic development and we select them according to the manipulative intent. But the basic force coordination expressed in these patterns has to be tuned to the physical properties of the current object, e.g. shape, surface friction and weight. This takes place primarily by parametric adjustments of the force output based on internal models of the target object, i.e. implicit memory systems that represent critical object properties. From visual or haptic information we identify objects and automatically retrieve the relevant models. These models are then used to adapt the motor commands prior to their execution. The formation of models and their swift updating with changes in object properties depend, however, on signals from tactile sensors in the fingertips. PMID- 9949816 TI - Motor areas on the medial wall of the hemisphere. AB - The primary motor cortex (M1) receives input from four premotor areas on the medial wall of the hemisphere: the supplementary motor area (SMA) and three cingulate motor areas located on the banks of the cingulate sulcus (CMAr, CMAd and CMAv). All four premotor areas have maps of the body containing distinct proximal and distal representations of the arm. Surprisingly, the size of the distal representation is comparable to or larger than the size of the proximal representation in each area. Thus, contrary to some previous hypotheses, the anatomical substrate exists for the premotor areas on the medial wall to be involved in the control of distal, as well as proximal arm movements. Each of the premotor areas on the medial wall also has substantial direct projections to the spinal cord. Corticospinal axons from these premotor areas terminate in the intermediate zone of the spinal cord. Some corticospinal axons from SMA, CMAd, and CMAv terminate around motoneurons. In this respect, these motor areas are like M1 and appear to have direct connections with spinal motoneurons, particularly those innervating muscles of the fingers and wrist. These results suggest that the premotor areas on the medial wall are an important source of descending commands for the generation and control of movement. In recent experiments we examined the pattern of functional activation in the premotor areas on the medial wall during the performance of sequences of pointing movements. The patterns of activation were then compared with the body maps revealed by our anatomical studies. Overall, our initial results indicate that the attributes of motor control are unequally represented across the premotor areas. For example, one of the areas on the medial wall, the CMAd, was strongly and selectively activated during the performance of highly practised, remembered sequences of movement. Further insights into the function of the premotor areas are likely to come from examining their participation in a broad range of behavioural paradigms. These initial results support our hypothesis that each premotor area makes some unique contribution to the planning, initiation and/or execution of movement. PMID- 9949817 TI - Grasping objects and grasping action meanings: the dual role of monkey rostroventral premotor cortex (area F5). AB - Monkey area F5 consists of two main histochemical sectors, one buried inside the arcuate sulcus, the other located on the cortical convexity. Neurons of both sectors discharge during hand movements. Many of them also fire in response to the presentation of visual stimuli. However, the visual stimuli effective for triggering the neurons in each sector are markedly different. Neurons located in the bank of the arcuate sulcus respond to the observation of 3D objects, provided that object size and shape is congruent with the prehension type coded by the neuron ('canonical' F5 neurons). Neurons of the convexity discharge when the monkey observes hand actions performed by another individual, provided that they are similar to the motor action coded by the neuron ('mirror' neurons). What do the canonical F5 neurons and the surprising mirror neurons have in common? The interpretation we propose is that these two categories of F5 neurons both generate an internal copy of a potential hand action. In the case of 'canonical' neurons, this copy gives a description of how to grasp an object; in the case of mirror neurons it gives a description of an action made by another person. Because the individuals know the consequences of their actions, we propose that the internal motor copies of the observed actions represent the neural basis for understanding the meaning of actions made by others. PMID- 9949818 TI - Posterior parietal areas specialized for eye movements (LIP) and reach (PRR) using a common coordinate frame. AB - The posterior parietal cortex (PPC) has long been considered a sensory area specialized for spatial awareness and the directing of attention. However, a new, far reaching concept is now emerging that this area is involved in integrating sensory information for the purpose of planning action. Moreover, experiments by our group and others over the last two decades indicate that PPC is in fact anatomically organized with respect to action. PPC also is an 'association' cortex which must combine different sensory modalities which are coded in different coordinate frames. We have found, at least for two different cortical areas within PPC, that different sensory signals are brought into a common coordinate frame. This coordinate frame codes locations with respect to the eye, but also gain modulates the activity by eye and body position signals. An interesting feature of this coordinate representation at the population level is that it codes concurrently target locations in multiple coordinate frames (eye, head, body and world). Depending on how this population of neurons is sampled, different coordinate transformations can be accomplished by the same population of neurons. PMID- 9949819 TI - How do visual instructions influence the motor system? AB - The paper distinguishes the use of visual cues to guide reaching and grasping, and the ability to learn to associate arbitrary sensory cues with movements. Using positron emission tomography (PET), we have shown that the arbitrary association of visual cues and movements involves the ventral visual system (prestriate, inferotemporal and ventral prefrontal cortex), the basal ganglia and the dorsal premotor cortex. Using functional magnetic resonance imaging (fMRI), we have shown that the evoked haemodynamic responses in the ventral visual system are time-locked to the presentation of the visual cues, that the response in the motor cortex is locked to the time of response, and that the response in the dorsal premotor cortex shows cuerelated, movement-related and set-related components. Using PET we have shown that there are learning-related changes in activation in both the ventral prestriate cortex and the basal ganglia (globus pallidus) when subjects learn a visuomotor associative task. We argue that the basal ganglia may act as a flexible system for learning the association of sensory cues and movements. PMID- 9949820 TI - Online visual control of the arm. AB - The psychophysical and cerebrocortical mechanisms in visually guided reaching movements and isometric force pulses are discussed. The results of psychophysical studies of pointing movements have demonstrated a tight coupling between the visual information and the direction of the movement, and those of studies of directed isometric force pulses have documented the sensitive dependence of the motor system on the continuous availability of visual information for the ongoing correction of directional deviations from the instructed direction. Recordings of the activity of single cells in the motor cortex and parietal areas 2 and 5 have revealed the same tight, online coupling between visual information and cell discharge, and have partially elucidated the neural mechanisms underlying this function at the cortical level. PMID- 9949821 TI - Cortical control of whole-arm motor tasks. AB - Making an arbitrary motor response to a sensory signal would appear to require at least two sequential steps--planning the appropriate response and generating a motor command to implement it. However, neuronal correlates of these two putative steps do not occur in strict serial order, nor are they subserved by separate cortical regions. Instead, they are distributed in a continuous, overlapping and non-uniform manner across the cerebral cortex, including primary motor, premotor and parietal regions. These processes take the form of temporal and spatial gradients of cell activity that are distributed within and across cortical regions. Instead of two serial steps, these neuronal events may be better described in terms of two parallel functions--action specification and action selection. These processes occur continuously, both before and during movement. Recent studies show that the activity of single cells in the caudal part of the primary motor cortex is strongly modulated by arm geometry and by task dynamics during whole-arm isometric and reaching tasks. This indicates that these cells contribute to the transformation between neural representations of the global attributes of motor actions and of the mechanical details of their implementation. PMID- 9949822 TI - The importance of the cortico-motoneuronal system for control of grasp. AB - Our recent work has revealed new evidence of the importance of direct cortico motoneuronal (CM) connections for voluntary control of the hand. Most of these connections are derived from corticospinal neurons located in the M1 hand area, although there are some much smaller contributions from other secondary motor areas, such as the supplementary motor area (SMA). Intracellular recordings show that 75% of upper limb motoneurons in the chloralose-anaesthetized macaque monkey receive a monosynaptic projection from the corticospinal tract; evidence for non monosynaptic, propriospinal excitatory influences from the corticospinal tract was conspicuously lacking in these anaesthetized preparations. Moreover, in the conscious monkey, hand and arm muscle motor unit responses to corticospinal tract input are dominated by single, brief peaks compatible with monosynaptic excitation. CM excitatory post-synaptic potentials, recorded from a comparable sample of hand and arm motoneurons in anaesthetized macaque and squirrel monkeys, were found to be larger and faster rising in the macaque, which is by far the more dexterous of the two species. CM cells facilitating a given muscle in the conscious macaque are distributed over a wide region of M1 cortex, and each contributes a particular pattern of discharge during a skilled task. In addition to their direct effects on target muscles there may be weaker but potentially important effects that derive from the synchronous binding of assemblies of output neurons. Synchronous oscillations between these neurons are particularly prevalent during steady grip, but disappear during digit movement. PMID- 9949823 TI - Combination, complementarity and automatic control: a role for the cerebellum in learning movement coordination. AB - We have examined several different paradigms of adaptation and of 'acquisition of skill'--skill defined as a movement specialized to meet a certain goal and gained through practice. In each paradigm, change occurs through trial-and-error performance. In some of the tasks, damage of cerebellar cortex impairs adaptation and not performance. The deficits in performance cannot explain the deficits in adaptation. In some of the tasks, the discharge of Purkinje cells and, by inference, the discharge of inferior olive cells and mossy fibres has behaved in a manner consistent with the Marr-Albus theory of motor learning. We extend the theory to show how parallel fibres could implement both the coordination of complex movements and the learning of new movements. The size of the response combinations would be proportionate to the length of parallel fibres. The mechanism proposed here would permit optimized complex movement behaviours to respond to specific behavioural contexts rapidly, stereotypically and automatically. The mechanism would permit storage of many context-response couplings, and many complex responses. The mechanism would permit privacy, individuality and a large number of behavioural responses. PMID- 9949824 TI - Construction of a reach-to-grasp. AB - Reaching out to grasp an object requires the coordinated action of many different areas of the brain. Each area probably makes a unique contribution to the control of limb movement. We have studied the discharge of interpositus, the output nucleus of intermediate cerebellum, and magnocellular red nucleus, which connects interpositus to the spinal cord. The neurons in these areas discharge at high rates only if a hand movement is included with the reach, and discharge pattern is similar regardless of reach direction. Therefore, interpositus and magnocellular red nucleus are involved primarily in grasp control during the reach-to-grasp; other areas must be controlling the reach. Several other areas of the brain, including the reticular formation, rostral mesencephalon, superior colliculus and motor cortex, are active during reaching. The output from these descending systems converges on interneurons at spinal level C1 and C2 which, in turn, project to level C6, where motor neurons innervating shoulder muscles are located. We hypothesize that reach control is achieved by the convergence of multiple descending pathways onto a complex spinal interneuronal system. PMID- 9949825 TI - Cerebellum and the sensory guidance of movement. AB - By the end of the 19th century the locations of the primary visual and motor areas of the cerebral cortex were well recognized. At that time it was generally assumed that for the visual control of movement visual areas must be linked to motor areas by way of a series of cortico-cortical fibres. Subsequent experimental evidence showed clearly, however, that skilled visuomotor performance is still possible after complete disconnection of interhemispheric and intracortical fibre systems. Preservation of skilled visuomotor performance after such lesions has often been thought to be mediated by ipsilaterally descending motor pathways. However, the evidence indicates that there must also be subcortical pathways that link sensory to motor areas of the brain. One such pathway involves the cerebellum. There is a massive input from cortical and subcortical visual areas to the pontine nuclei. Cells in the pontine nuclei respond vigorously to appropriate visual targets and they distribute their axonal terminals bilaterally in the cerebellar cortex. A cortico-ponto-cerebellar circuit would have remained intact in all cases in the literature in which there was complete disconnection of cortico-cortical fibres between visual and motor cortex. Lesions of the cortical sensory areas that project to the pons or interruption of the fibres within the internal capsule or basis pedunculi, that link cortical sensory areas with the pontine nuclei, can severely impair the sensory guidance of movement. This paper reviews the evidence for sensory input to the cerebellum and the possible role of a cortico-ponto-cerebellar circuit in the sensory guidance of movement. PMID- 9949826 TI - The cerebellum, predictive control and motor coordination. AB - I argue that the cerebellum has at least two related roles, both sub-served by its operation as a 'forward model' of the motor system. First, it provides an internal state estimate or sensory prediction that is used for online control of movements; second, these predictive state estimates are used to coordinate actions by different effectors in the normal coordination of eye and hand, reach and grasp, etc. Preliminary electrophysiological data from cerebellar cortical neurons in the monkey supports the hypothesis that a proportion of cells code for the sensory consequences of movement. In a contrast between normal visually guided movement of a cursor and mirror reversed movement, approximately half the sample of 47 directionally sensitive cells were found to code for the movement of the cursor controlled by the monkey's limb, and not the limb movement itself. Functional imaging of the human cerebellum further supports the hypothesis that the cerebellum is involved in motor coordination. Subjects were tested performing ocular tracking, manual tracking without eye movement, or combined eye and hand tracking. Activation of cerebellar areas related to movement of eyes or hand alone was significantly enhanced when the subjects performed coordinated eye and hand tracking of a visual target. PMID- 9949828 TI - The apraxias are higher-order defects of sensorimotor integration. AB - The classical features of motor disorders due to neurological disease affecting the pyramidal pathways, cerebellum and basal ganglia in humans are well known. What is less understood is the clinical world of apraxia--'inability to perform purposeful skilled movements in the absence of any elementary motor (weakness, akinesia, abnormal posture or tone) or sensory deficits, or impaired comprehension or memory'. Much of what clinicians call apraxia is a failure of gesture production to command, due to problems of transcoding language into motor action, without motor deficit in ordinary life. However, damage to premotor regions and superior parietal lobules provokes devastating spontaneous higher order motor deficits, including limb-kinetic apraxia, diagnostic apraxia, visuomotor apraxia and ideational apraxia. PMID- 9949827 TI - Internal models for motor control. AB - The process of moving the hand to a target in space involves a series of sensorimotor transformations that translate visual and other sensory information about the location of the target object and the limbs into a set of motor commands that will bring the hand to the desired position. Recent work at various laboratories has provided strong support for the hypothesis that the CNS learns and maintains internal models of sensorimotor transformations. An internal model is a neural system that mimics the behaviour of the sensorimotor system and objects in the external environment. Internal models enable the CNS to predict the consequences of motor commands and to determine the motor commands required to perform specific tasks. In this chapter, we first summarize recent computational, behavioural and neurophysiological studies that address the theoretical necessity of internal models, the locations of internal models, and the neural mechanism for acquiring internal models through learning. Then, we propose a new computational model of multiple internal models. PMID- 9949829 TI - Caspases in cell death. PMID- 9949830 TI - Proteolytic targets in cell death. PMID- 9949831 TI - The point of no return: mitochondria, caspases, and the commitment to cell death. AB - Apoptosis is a specialized mode of cell death finely regulated at the molecular level and conserved throughout evolution. In many instances during normal development or in order to maintain the homeostasis of a multicellular organism, a strategic intracellular program is initiated ensuring the fate of unwanted cells. Interference with this program has been implicated in many pathologies, particularly in cancer and autoimmune diseases. What is most important, from the organism's point of view, is that the dismissal of the outcast cells is accomplished serenely, i.e., the dying cells resign their existence without causing an inflammatory reaction. Therefore, the ability to manipulate the cell death machinery is an obvious goal of medical research. Here, we debate the idea of the point-of-no-return and propose models for the role of "initiator" and "executioner" caspases in the death program. We argue that, in many circumstances, the cells are committed to die before the execution phase of apoptosis starts. This commitment event is coordinated by the mitochondria and can be blocked by anti-apoptotic oncogenes. PMID- 9949832 TI - Serpins and regulation of cell death. AB - Proteolysis is a key feature of programmed cell death. Extracellular proteinases can activate cell surface receptors which trigger apoptosis, and the effector machinery requires the activation and activity of numerous intracellular proteinases (primarily caspases). Effective control of proteolysis is essential for homeostasis and can occur at two levels: regulation of proteinase activation, and regulation of the activated proteinase. Serpins control activated proteinases and several have been implicated in the regulation of cell death. Serpins that inhibit intracellular processes include the viral proteins CrmA and SPI-1, as well as the granzyme B inhibitor, PI-9. Another endogenous serpin, PN-I, prevents the delivery of an apoptotic signal by inhibiting an extracellular proteinase from cleaving a cell surface receptor. There is evidence to suggest that PAI-2 may target an extracellular as well as an intracellular proteinase. Much of our knowledge of proteolysis within apoptotic cells has come from studies using the poxvirus serpin CrmA/SPI-2. CrmA prevents cytokine processing by inhibiting caspase-1, and protects against Fas-, TNF- and TRAIL-mediated apoptosis by inhibiting an unidentified proteinase specific to these pathways. Work with CrmA has also clearly demonstrated that there are separable effector mechanisms within cells, and that those triggered by growth factor withdrawal, matrix dissociation or cytotoxic ligands are different in several respects to those triggered by radiation, chemicals or steroid hormones. It is likely that analysis of other poxvirus serpins with different inhibitory profiles (especially SPI-1) will yield further insights into these processes. Prospecting for intracellular serpin genes in other virus species may also be fruitful. Finally, all of the serpins known to regulate intracellular proteolysis are members of the ovalbumin subgroup. It remains to be seen whether the more recently described "orphan" ovalbumin serpins (Riewald and Schleef 1995; Sprecher et al. 1995; Sun et al. 1997) also have roles in the regulation of cell death. PMID- 9949833 TI - The IAP family of apoptotic regulators. PMID- 9949834 TI - Apoptosis versus necrosis: the shape of neuronal cell death. PMID- 9949835 TI - Prevention of neuronal cell death by Bcl-2. PMID- 9949836 TI - CD95 (APO-1/Fas) in hematopoietic diseases. PMID- 9949837 TI - The cornified envelope: a model of cell death in the skin. PMID- 9949838 TI - Radiation-induced cell death and its implications in human disease. PMID- 9949840 TI - [Total parenteral nutrition in cancer patients]. PMID- 9949839 TI - T cell apoptosis in HIV infection: mechanisms and relevance for AIDS pathogenesis. PMID- 9949841 TI - [Total parenteral nutrition in the treatment of postoperative entero- and biliary cutaneous fistula]. PMID- 9949842 TI - [Lipid feeding in oncology]. PMID- 9949843 TI - [Effect of FDP on adenylic coefficient of charges]. PMID- 9949844 TI - [Use of fructose diphosphate to correct altered oxyphoretic hemoglobin in seriously ill patients]. PMID- 9949845 TI - [Rapid infusion of fructose-1,6-diphosphate (FDP) in total parenteral nutrition (TPN). Control of some metabolic effects and possibility of reducing administration of exogenous insulin]. PMID- 9949846 TI - [Preliminary clinical results with fructose-1,6-diphosphate in patients with hyperinsulinism]. PMID- 9949847 TI - [Hepatic scintigraphy during total parenteral nutrition (TPN). Preliminary study]. PMID- 9949848 TI - [Programmed perfusion anesthesia with althesin. Preliminary clinical results]. PMID- 9949849 TI - [Programmed perfusion anesthesia with ketamine. Preliminary clinical results]. PMID- 9949850 TI - [Possible use of althesin in neurosurgery for extra-intracranial arterial anastomosis]. PMID- 9949851 TI - [Prevention of hypertensive crisis by narcosis induction in vascular surgery]. PMID- 9949852 TI - [Evaluation of dopamine and serotonin turnover induced by some intravenous anesthetics]. PMID- 9949853 TI - [Electroanalgesia in childbirth pain]. PMID- 9949854 TI - [Use of intravenous flunitrazepam. Minimal dose for loss of conciousness]. PMID- 9949855 TI - [Pharmacokinetic profile of etomidate]. PMID- 9949856 TI - [Use of etomidate in continuous perfusion. Preliminary clinical experience]. PMID- 9949858 TI - Development of HIV protease inhibitors: a survey. AB - In the treatment of infections caused by rapidly mutating viruses like human immunodeficiency virus (HIV), combination therapy with multiple drugs acting by different mechanisms offers several advantages over monotherapy. It may provide: synergistic effect, possible reduction of dosages and side-effects, and reduction of the chance of drug resistance. In the past few years, hundreds of HIV protease inhibitors have been synthesized and tested in order to overcome the limitations of reverse transcriptase inhibitors like zidovudine and others. In this review, emphasis is placed on the development of HIV protease inhibitors as antiviral agents against HIV, and structure-activity relationship analysis of saquinavir and related compounds. Limitations of some protease inhibitors and ways to overcome the shortcomings are presented. Among these many protease inhibitors four have been marketed during 1995-1997. They are saquinavir, ritonavir, indinavir and nelfinavir. Their different structural features, important physicochemical, pharmacokinetic and clinical profiles are presented in a table form for easy comparison. It is hoped that in the future new drugs based on additional mechanisms can be developed for the treatment of AIDS. PMID- 9949857 TI - [Parenteral nutrition treatment in serious eclampsia]. PMID- 9949859 TI - Insulin resistance, impaired glucose tolerance and non-insulin-dependent diabetes, pathologic mechanisms and treatment: current status and therapeutic possibilities. AB - Impaired glucose tolerance and non-insulin-dependent diabetes (NIDDM) are the pathologic consequence of two co-incident and interacting conditions, namely insulin resistance and relative insulin deficiency. Recognised by the World Health Authority as a global health problem there are at 1995 estimates at least 110 million diagnosed diabetics world wide with at least the same number undiagnosed. Diabetes is the 4th leading cause of death in developed countries and its management exerts a vast economic and social burden. Insulin resistance is established as the characteristic pathologic feature of patients with glucose intolerance and NIDDM describing a state in which insulin stimulated glucose uptake and utilisation in liver, skeletal muscle and adipose tissue is impaired and coupled to impaired suppression of hepatic glucose output. Although the biochemical mechanisms underpinning both defects are becoming better understood, the genetic and molecular causes remain elusive; and whether insulin resistance or relative insulin deficiency represents the primary defect in patients with NIDDM is the matter of some debate. In this article we review the biochemical and molecular nature of the defects in insulin sensitivity and glucose uptake, and discuss some of the potential causative mechanisms. The genetic and environmental basis of insulin resistance is reviewed and presented, and potential therapeutic targets including thiazolidinediones are discussed. PMID- 9949860 TI - Peptide drug delivery into the central nervous system. AB - The microvasculature of the central nervous system (CNS) is characterized by tight junctions between the endothelial cells and, thus, behaves as a continuous lipid bilayer that prevents the passage of polar and lipid-insoluble substances such as peptides. Highly active enzymes expressed in the morphological components of the microcirculation also represent a metabolic component that contributes to the homeostatic balance of the CNS. Peptides generally cannot enter the brain and spinal cord from the circulating blood because they are highly polar and lipid insoluble, metabolically unstable, and active transport systems only exist for very few of them in this membraneous barrier separating the systemic circulation from the interstitial fluid of the CNS. This blood-brain barrier is, therefore, the major obstacle to peptide-based drugs that are potentially useful for combating diseases affecting the brain and spinal cord. This review discusses and critically evaluates invasive, chemical-enzymatic (prodrug and chemical delivery/targeting system) and biological carrier-based approaches to overcome the blood-brain barrier for these highly active and versatile molecules that are very attractive as a future generation of neuropharmaceuticals. PMID- 9949861 TI - Abnormalities of protein kinases in neurodegenerative diseases. AB - In neurodegenerative diseases such as ALS and AD there is evidence for abnormal regulation of protein kinases. In these diseases, altered activities and protein levels of several specific kinases suggest that abnormal phosphorylation is present and this aberrant phosphorylation may be involved in the pathogenesis of these diseases. The observation that regulation of the NMDA receptor ion channel is altered in tissue from ALS patients may arise from the abnormal phosphorylation state of the protein kinase regulating NMDA receptor function. Whether the abnormalities of these protein kinases is a primary event leading to altered receptor regulation or vice versa is still poorly understood. The seemingly multiple pathogenic mechanisms of ALS and AD create complexity in assessing a primary cause that may lead to cell death. The mechanisms causing cell death (apoptosis or necrosis) may be overlapping with integrated events among the components interacting and contributing to a final pathway for neuron death. Thus, evidence of impairment in protein kinase signalling in these diseases may be a primary cause, a secondary event, or a compensatory mechanism. To further study this issue, different model systems could be beneficial to obtain a better understanding of these diseases. PMID- 9949862 TI - Biomimicry as a basis for drug discovery. AB - Selected works are discussed which clearly demonstrate that mimicking various aspects of the process by which natural products evolved is becoming a powerful tool in contemporary drug discovery. Natural products are an established and rich source of drugs. The term "natural product" is often used synonymously with "secondary metabolite." Knowledge of genetics and molecular evolution helps us understand how biosynthesis of many classes of secondary metabolites evolved. One proposed hypothesis is termed "inventive evolution." It invokes duplication of genes, and mutation of the gene copies, among other genetic events. The modified duplicate genes, per se or in conjunction with other genetic events, may give rise to new enzymes, which, in turn, may generate new products, some of which may be selected for. Steps of the inventive evolution can be mimicked in several ways for purpose of drug discovery. For example, libraries of chemical compounds of any imaginable structure may be produced by combinatorial synthesis. Out of these libraries new active compounds can be selected. In another example, genetic system can be manipulated to produce modified natural products ("unnatural natural products"), from which new drugs can be selected. In some instances, similar natural products turn up in species that are not direct descendants of each other. This is presumably due to a horizontal gene transfer. The mechanism of this inter-species gene transfer can be mimicked in therapeutic gene delivery. Mimicking specifics or principles of chemical evolution including experimental and test-tube evolution also provides leads for new drug discovery. PMID- 9949863 TI - Serotonin in migraine: theories, animal models and emerging therapies. AB - A role for serotonin in migraine has been supported by changes in circulating levels of serotonin and its metabolites during the phases of a migraine attack, along with the ability of serotonin-releasing agents to induce migraine-like symptoms. The development of serotonin receptor agonists with efficacy in the clinic for the alleviation of migraine pain further implicates serotonin as a key molecule in migraine. Several theories regarding the etiology of migraine have been proposed. The vasodilatory theory of migraine suggested that extracranial arterial dilation during an attack was related to migraine pain; a theory supported when vasoconstrictors such as sumatriptan alleviated migraine pain. The neurological theory of migraine proposed that migraine resulted from abnormal firing in brain neurons. Cortical spreading depression, one facet of the neurological theory, could explain the prodrome of migraine. The neurogenic dural inflammation theory of migraine supposed that the dural membrane surrounding the brain became inflamed and hypersensitive due to release of neuropeptides from primary sensory nerve terminals. Substance P, calcitonin gene related peptide and nitric oxide are all though to play a role in the dural inflammatory cascade. Animal models of migraine have been utilized to study the physiology of migraine and develop new pharmaceutical therapies. One model measures the shunting of blood to arteriovenous anastomoses based on a proposal that migraine primarily involves cranial arteriovenous vasodilation. Another model utilizes electrical stimulation of the trigeminal ganglion to induce neurogenic dural inflammation quantified by the resulting extravasation of proteins. Pharmacological agents such as meta-chlorophenylpiperazine (mCPP) and nitroglycerin have also been used to induce dural extravasation in animals. Both compounds also induce migraine attacks in individuals with a history of migraine. In addition, Fos, a protein produced by activation of the c-fos gene, has been measured as an index of migraine-like pain transmission to the CNS following chemical or electrical stimulation of the trigeminal nerve. A role for serotonin in migraine is further supported by the efficacy of serotonin receptor ligands. Sumatriptan is an agonist at 5-HT1D and 5-HT1B receptor subtypes, and effective in treating migraine pain and associated symptoms. Recently, selective 5-HT1F agonists have been proposed for the treatment of migraine, without the side effects associated with the present 5-HT1D and 5-HT1B receptor agonists. A role for 5-HT2B receptors has also been suggested the initiation of migraine, supporting use of selective 5 HT2B receptor antagonists in migraine. Thus, agents that modulate 5-HT1B, 5-HT1D, 5-HT1F and 5-HT2B receptors either have or may have clinical utility in the therapy of migraine headache. PMID- 9949864 TI - The application of high-throughput screening to novel lead discovery. AB - The ability to discover new lead compounds for novel therapeutic targets is a pivotal step in drug discovery programmes. High-throughput screening (HTS) utilises a number of platforms for the rapid screening of novel targets to accelerate this process. Key issues in HTS include assay configuration and the ability of a high-throughput screen to predict drug-target interactions accurately. This review highlights a number of issues in the HTS process and describes three key target areas that are likely to be sources of novel, therapeutically important drugs. Particular emphasis is placed on the mechanistic basis of drug-target interactions that are of prime importance in the design of HTS approaches. Critical aspects of information management related to HTS are summarised. PMID- 9949865 TI - Characterization and analysis of D-amino acids. AB - The need to screen a large number of natural extracts, with the aim of detecting D-amino acids or isolating and characterizing peptides containing them, has stimulated the development of novel and improved procedures for the analysis of amino acid enantiomeric mixtures, with special attention paid to automation. Different methods for the analysis of D-amino acids are described and discussed. PMID- 9949866 TI - Occurrence and function of D-amino acid-containing peptides and proteins: antimicrobial peptides. AB - Antimicrobial peptides are widely distributed in living organisms, where they represent a constitutive defence system acting as a first line of response against infections. The number of such peptides discovered has increased rapidly in the last few years, and more than 100 have been described from different sources. So far, antimicrobial peptides containing a D-amino acid have only been found in the skin secretions of frogs belonging to the genus Bombina. In the second position of the sequence of the mature peptides either D-alloisoleucine or D-leucine were detected. The D-amino acids are derived from the corresponding L forms by an as yet unknown posttranslational reaction. PMID- 9949867 TI - Molluscan neuropeptides. AB - Achatin-I, fulicin, fulyal, Mytilus-FFRFamide and Helix CCAP-RP-III are D-amino acid-containing neuropeptides from molluscs. Achatin-I, fulicin and fulyal from Achatina showed excitatory and/or modulatory actions on the penis retractor, radula retractor or ventricular muscles and neurons, though their L isomers were devoid of activity. On the other hand, both Mytilus-FFRFamide and its L isomer showed excitatory effects on the anterior byssus retractor muscle. Moreover, in contrast to Achatina neuropeptides, Helix CCAP-RP-III exhibited no remarkable activities on any of the muscles tested; instead, its L isomer possessed various excitatory effects. The molecular structures of these short peptides would be affected by the L-->D conversion and could influence activity. Molecular biological studies on the fulicin precursor suggest that fulicin, fulyal and related peptides are produced in Achatina ganglia and heart by processing of the ribosomally made precursor, and that L-isomeric fulicin and fulyal further undergo epimerization to yield the D-isomers. PMID- 9949868 TI - Opioid peptides from frog skin. AB - The skin of the South American frogs Phyllomedusa secretes, in addition to numerous mammalian-like hormones and neuropeptides, several gene-encoded opioid peptides that contain a D-amino acid in position 2 of their sequence. Dermorphin, Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2, dermenkephalin/deltorphin A, Tyr-D-Met-Phe-His Leu-Met-Asp-NH2 and the deltorphins, Tyr-D-Ala-Phe-Xaa-Val-Val-Gly-NH2 (where Xaa is either Asp or Glu) are highly potent at, and exquisitely selective, for the mu and delta-opioid receptors. D-Ala and D-Met present in dermorphin and related peptides are coded for by the usual codons in the corresponding messenger RNAs. Prepro-dermorphin/dermenkephalin and prepro-deltorphins have considerable sequence identities to precursors encoding 10-46-residue-long antimicrobial peptides--dermaseptins, brevinins, temporins, esculentins and gaegurins- originating from various amphibian species. The similarity between the prepro regions of precursors encoding end products with strikingly different structures and biological activities supports the suggestion that the genes encoding these peptides are all members of the same family. PMID- 9949869 TI - D-amino acids in crustacean hyperglycemic neurohormones. PMID- 9949870 TI - Biosynthesis of D-amino acid-containing peptides: exploring the role of peptide isomerases. AB - The discovery of D-amino acid residues in a growing number of gene-encoded peptides suggests that such biochemical modifications are more common than initially thought. In fact, the extent to which D-amino acids are incorporated into peptides by multicellular organisms probably has not been fully realized, since routine Edman sequencing does not provide the absolute stereochemistry of amino acid residues. Unless both the D and L isomers of a particular peptide sequence are isolated, D-amino acid-containing peptides are often identified only after synthesis of naturally-occurring peptide fails to yield the desired activity. To date, D-amino acid residues (e.g., alanine, methionine, leucine, isoleucine, phenyl alanine, asparagine, tryptophan and serine) have been identified in peptides from a variety of species, including frogs, snails, clams, lobsters and spiders. While most have a single D-amino acid residue located near their N-termini, an exception is found with omega-Aga IVB. The examples highlighted in this chapter are the result of a unique strategy of multicellular organisms to circumvent stereochemical limitations imposed by the genetic code in an effort to increase molecular diversity. The presence of D-amino acids permits the generation of novel tertiary structure that could not be accessed from L amino acids alone. Moreover, advantages of increased potency and protease stability are often observed. Our understanding of the biosynthesis of these D amino acid-containing peptides is still in its infancy. Nevertheless, the discovery of a novel peptide isomerase from the venom of the Agelenopsis aperta spider provides some important clues to explain the incorporation of single D amino acid residues within a peptide chain. Given its high homology with other serine proteases, the isomerase may represent an opportune mutation in response to evolutionary pressures. Yet, is the isomerase a unique exception or simply the first in a class of enzymes of varying substrate specificity capable of synthesizing D-amino acid-containing peptides? To be sure, much more remains to be explored about the precise timing and mechanism of the isomerization process, in addition to obtaining further structural data on the enzyme itself. Therein lies the continuation of this fascinating story in enzyme biochemistry. PMID- 9949871 TI - Appearance of D-amino acids during aging: D-amino acids in tumor proteins. AB - In 1939 Kogl and Erxleben [1-4] reported that tumor proteins contain appreciable amounts of D-amino acids, specifically glutamic acid, valine, leucine and lysine, implying that both the initiation and autonomous character of tumors depends on the formation and maintenance of these D-amino acids in the cell proteins. This postulate remained highly controversial for over 10 years, during which time several papers both supporting and refuting this hypothesis were published. The dispute existed almost entirely between Kogl, a vigorous and able protagonist at the University of Utrecht, Netherlands, and an impressive array of equally vigorous and able dissenters in the United Kingdom and Germany. An excellent review of both sides of this controversy was written by Miller in 1950 [5]. After many years and much effort the controversy then seemed to be put to rest. However, more than 40 years later the development of much more refined analytical techniques for the resolution and detection of amino acid enantiomers provided more definitive evidence that D-amino acids are not common to all tumor tissues and probably are not integral to the cancer process. This is not surprising when one considers that a tumor consists of fast-growing cells. Thus, there would not be sufficient time for any L-amino acid to racemize to the D isomer. Some D-amino acids may originate in foods consumed, but it is uncertain whether enzyme systems are able to incorporate D-amino acids into tumor proteins during growth. Nevertheless, if significant levels of D-amino acids were to be found in tumor proteins, the implications could be far-reaching. Confirmation of the presence of D-amino acids at any concentration in tumors would provide new insights into the mechanism for autogenesis and maintenance of tumors. PMID- 9949872 TI - D-amino acids in aging erythrocytes. AB - Mature human erythrocytes are highly differentiated cells which have lost the ability to biosynthesize proteins de novo. During cell aging in circulation, erythrocyte proteins undergo spontaneous postbiosynthetic modifications, regarded as "protein fatigue" damage, which include formation of isomerized and/or racemized aspartyl residues. These damaged proteins cannot be replaced by new molecules; nevertheless, data support the notion that they can be repaired to a significant extent, through an enzymatic transmethylation reaction. This repair reaction has therefore been used as a means to monitor the increase of altered aspartyl residues in erythrocyte membrane proteins during cell aging. The relationship between protein repair and aspartyl racemization in red blood cell stress and disease is discussed. PMID- 9949873 TI - D-amino acid hydrolysing enzymes. AB - Only a few enzymes that hydrolyse peptide bonds involving D-amino acids effectively have been discovered and characterised in multicellular organisms. Mammalian renal dipeptidase hydrolyses various dipeptides with a D-amino acid only at the C-terminal with similar efficiency to their L-amino acid diastereomers, but not dipeptides with an N-terminal D-amino acid residue. Nor does the enzyme act on tripeptides. Dipeptides similar to those hydrolysed by the enzyme are also hydrolysed by cytosolic leucine aminopeptidase, but much less effectively than their L-amino acid diastereomers. Peptidyl-D-amino acid hydrolase from cephalopods has a somewhat broader substrate specificity than the renal dipeptidase and hydrolyses, as well, some dipeptides with a D-amino acid at the N-terminal. It also acts on larger peptides than dipeptides, albeit slowly. Carnosinase is specific to dipeptides containing L-His as the C-terminal residue, and hydrolyses D-Ala-L-His about as well as carnosine. PMID- 9949874 TI - Homochirality and life. AB - After clarifying the frequently misused term homochirality, the crucial importance of homochirality and chiral purity in the development and maintenance of the essential biopolymers of life--proteins and nucleic acids--is discussed. The harsh and forbidding prebiotic environment during the era of cometary impact after formation of the Earth approximately 4.5 Gyr ago is described, after which the most important abiotic mechanisms proposed historically for the genesis of chiral molecules on the primitive Earth are enumerated. Random and determinate terrestrial mechanisms are each evaluated with regard to the environmental restraints imposed during the impact era, and it is concluded that all such mechanisms would be inapplicable and implausible in the realistic prebiotic environment. To circumvent these limitations, an extended hypothesis is presented describing an extraterrestrial source of homochiral terrestrial molecules. Illustrated in Figure 2, this scenario involves the partial asymmetric photolysis of the racemic constituents of organic mantles on interstellar dust grains by the circularly polarized ultraviolet components of the synchrotron radiation emanating from the neutron star remnants of super-novae. The resulting homochiral constituents with low enanantiomeric excesses (e.e.s) so produced in the organic mantles are subsequently conveyed to Earth either by direct accumulation or, more likely, after coalescence into comets or asteroids, followed by repetitive impingement during the impact era. Finally, the low e.e.s of the extraterrestrial homochiral molecules so introduced are amplified by terrestrial autocatalytic or polymerization mechanisms into a state of chiral purity, then are ultimately concentrated and protected by sequestration in the interiors of spontaneously formed protocellular vesicles--there to await further chemical evolution toward the biomolecules of life. Recent observations of the excess of L-over D-amino acids in the Murchison meteorite are cited as validation for the early stages of the proposed hypothesis. PMID- 9949875 TI - Fish cell lines as a tool in aquatic toxicology. AB - In aquatic toxicology, cytotoxicity tests using continuous fish cell lines have been suggested as a tool for (1) screening or toxicity ranking of anthropogenic chemicals, compound mixtures and environmental samples, (2) establishment of structure-activity relationships, and (3) replacement or supplementation of in vivo animal tests. Due to the small sample volumes necessary for cytotoxicity tests, they appear to be particularly suited for use in chemical fractionation studies. The present contribution reviews the existing literature on cytotoxicity studies with fish cells and considers the influence of cell line and cytotoxicity endpoint selection on the test results. Furthermore, in vitro/in vivo correlations between fish cell lines and intact fish are discussed. During recent years, fish cell lines have been increasingly used for purposes beyond their meanwhile established role for cytotoxicity measurements. They have been successfully introduced for detection of genotoxic effects, and cell lines are now applied for investigations on toxic mechanisms and on biomarkers such as cytochrome P4501A. The development of recombinant fish cell lines may further support their role as a bioanalytical tool in environmental diagnostics. PMID- 9949876 TI - Architectural pattern, tissue and cellular morphology in livers of fishes: relationship to experimentally-induced neoplastic responses. AB - The teleost liver is one of the most sensitive organs to show alteration in biochemistry, physiology and structure following exposure to various types of environmental pollutants. Despite the importance of this organ to environmental toxicology and to ecotoxicology where biomarkers of exposure and of deleterious effect are found, the architectural pattern is not well known. This chapter reviews an architectural plan for teleost liver and compares that to the often cited mammalian pattern. Hepatic tubules composed principally of hepatocytes and biliary epithelial cells are in close proximity to lacunae which are of mesodermal origin. As is described, the tubule and lacunae concepts provide a means to better interpret morphologic alterations following exposure. These concepts are used to illustrate features of the chronic toxicity following exposure to proven carcinogens. PMID- 9949877 TI - Immunochemical approaches to studies of CYP1A localization and induction by xenobiotics in fish. AB - There is an increasing understanding that polynuclear aromatic hydrocarbons (PAHs) and organochlorine compounds (like polychlorinated biphenyls (PCBs), certain pesticides and dioxins) in the aquatic environment may lead to physiological and pathological effects such as immunological disturbances, effects on reproduction and development, and even neoplasms. Exposure to pollutants may have consequences at all levels in the biological organization, from the cellular level over effects on the individual organism, population, to the entire ecosystem. The cytochrome P450 system (CYP or P450) has an essential function in the biotransformation of endogenous and exogenous compounds. The fact that many different environmental pollutants induce de novo synthesis of cytochrome P450 1A (CYP1A) proteins in fish, gives these enzymes an interesting position in aquatic toxicology. Many investigations concerning the CYP1A system in fish have been performed over the last two decades, demonstrating its usefulness as a biomarker for aquatic pollution. A general overview of the biochemical and toxicological aspects concerning the cytochrome P450 system will be given here, followed by a more detailed description of CYP1A induction responses in fish. Ecotoxicological consequences of CYP1A induction and the use of immunochemical techniques for CYP1A detection as a biomarker in environmental monitoring will be discussed. PMID- 9949878 TI - Origin of cadmium and lead in clear softwater lakes of high-altitude and high latitude, and their bioavailability and toxicity to fish. AB - As a consequence of atmospheric deposition, effects of pollutants such as acidification and metal contamination are evident even in remote aquatic ecosystems of mountain and polar regions. Due to similar environmental characteristics (e.g., oligotrophy, low buffering capacity, long ice-cover, high precipitation rates), clearwater high altitude and high latitude lakes represent very sensitive ecosystems, which are extremely susceptible to even slight changes of the environment. Thus, the environmental relevance of Cd and Pb for both types of lakes is discussed in relation to their extraordinary sensitivity to environmental changes. The impact of Cd and Pb on fish from high altitude and high latitude lakes is reviewed and biotic and abiotic factors controlling bioavailability and toxicity of metals to fish are summarized. Apart from direct toxic effects of low pH, acidification increases the bioavailability of metals for fish. Furthermore, low concentrations of dissolved organic carbon and suspended particles take influence on the uptake and toxicity of metals in fish from clear high altitude and high latitude lakes. Since even very low concentrations of Cd and Pb may result in high metal concentrations in fish, evaluation of critical metal loads for clear high altitude and high latitude lakes is of major importance. PMID- 9949879 TI - Multiple stressors in the Sacramento River watershed. AB - Aquatic biota in the Sacramento River watershed are stressed by diversion of river flows, by historical mining resulting in cadmium, copper, zinc, and mercury, and, more recently, contamination by agricultural and urban chemical runoff. In addition, the proposed redirection of drainage of saline waters- containing selenium--from the western slope of the San Joaquin River into the Delta formed by the confluence of the Sacramento and San Joaquin Rivers could add to the stress on resident organisms. These combined stressors have led to deterioration in surface water quality and the aquatic habitat. The potential interaction of these stressors, coupled with invasions of foreign species and the export of juvenile fish into aqueducts, has driven several species of fish to near extinction in the system. Effects of historical contamination by heavy metals are potentially exacerbated by presence of organophosphate pesticides, at concentrations exceeding National Academy of Sciences recommendations, throughout the lower watershed and the San Francisco Bay. The Asian clam, Potamocorbula amurensis, an introduced non-indigenous species has apparently become a preferred food item of the sturgeon, Accipenser transmontanus, an important sport and aquaculture species. Since this introduction, sturgeon body burdens for selenium have increased dramatically and analytical chemistry of P. amurensis indicates that these organisms are effective bioaccumulators of selenium. This review examines potential ecotoxicity associated with multiple stressors in the watershed. Data from field monitoring, laboratory toxicity assays with ambient water, and ecotoxicologic investigations are reviewed. Potential designs for multiple stressor investigations are discussed. The information presented on this watershed illustrates the challenge to investigators seeking to evaluate multiple stressor effects on riverine and estuarine organisms. PMID- 9949880 TI - Effects of estrogenic substances in the aquatic environment. AB - This review describes the research that has been carried out into estrogenic effects occurring in aquatic environments, both freshwater and marine, and the substances found to be responsible. In summary, estrogenic (and probably some anti-androgenic) activity has mainly been detected in a variety of treated sewage and other effluents, but also as a result of certain chemical spills and deliberate applications. This activity has resulted in a number of effects in vertebrate wildlife that can best be described as feminization, although the severity of these effects ranges from biomarkers of exposure such as vitellogenin induction in males through to morphological changes in sex organs and complete sex reversal. The implications of these changes for the future of aquatic wildlife populations have not yet been thoroughly explored. It is unlikely that all the causative substances have yet been discovered, but those which have been positively identified include natural and synthetic estrogenic hormones, natural plant sterols, synthetic alkylphenols, and certain organochlorine substances. The review concludes that there is now a need to investigate the consequences for wildlife populations of exposure to these materials, by means of a variety of field experiments and investigations. PMID- 9949881 TI - Bioaccumulation of contaminants in fish. AB - The term bioaccumulation is defined as uptake, storage, and accumulation of organic and inorganic contaminants by organisms from their environment. Bioaccumulation therefore results from complex interactions between various routes of uptake, excretion, passive release, and metabolization. For fish, the bioaccumulation process includes two routes of uptake: aqueous uptake of water borne chemicals, and dietary uptake by ingestion of contaminated food particles. The contribution to bioaccumulation that results from aqueous exposure and is taken up by the gills is called bioconcentration. The contribution to bioaccumulation resulting from dietary exposure via uptake by intestinal mucosa is termed biomagnification. In both cases, important co-determinants for bioaccumulation are the various elimination mechanisms. This chapter presents a short historical survey of the problem of bioaccumulation with particular reference to fish and of the various approaches to study bioaccumulation. This is followed by an overview of our present knowledge about basic physico-chemical determinants that either increase or reduce the bioaccumulation potential of various chemicals, and about the physiological basis of gills, blood circulation and intestines, as far as they are crucial for our understanding of uptake and accumulation. Finally, selected quantitative data and modelings of bioaccumulation in fish will be discussed, with regard to such problems as the relative importance of aqueous and dietary uptake. PMID- 9949882 TI - ART success and in vivo sperm cell selection depend on the ultramorphological status of spermatozoa. AB - Management of male infertility has recently shifted from treatment of the subfertile man towards techniques of assisted reproduction (ART). This study aimed to evaluate the possible role of the ultramorphological status of the spermatozoon with respect to sperm selection in vivo and prediction of ART success. Ultramorphological sperm parameters were assessed retrospectively for 92 males with sufficient sperm density (10(7) spermatozoa ejaculate-1) whose wives conceived following a stepwise discarding of the female genital tract barriers, using intra-uterine insemination (IUI) (n = 26), in vitro fertilization (IVF) (n = 45) or intracytoplasmic sperm injection (ICSI) (n = 21). In parallel, sperm samples of 71 fertile males were examined. Normal ultramorphology of all head and tail subcellular organelles was found to be essential for the ability of spermatozoa to pass the lower female genital tract. The ultramorphological migration threshold for this barrier is apparently higher than that essential for oocyte fertilization. No specific indication associated with passage through the upper genital tract was found. A high prevalence of axonema defects was found to impair the ability of sperm cells to penetrate the oocyte investment. The natural fertility index, based on routine sperm parameters and the ultrastructural status of the spermatozoon's subcellular organelles was confirmed to be beneficial for directing patients to ART. A discriminative score based on axonema integrity was found to contribute additional information for the first choice decision between conventional ART and ICSI (75% prediction ability). Thus it may be helpful in finding the simplest and least expensive procedure with the greatest long-term chance for pregnancy. PMID- 9949883 TI - Pentoxifylline stimulates various sperm motion parameters and cervical mucus penetrability in patients with asthenozoospermia. AB - Pentoxifylline (PTX) was incubated in vitro with human spermatozoa to examine its effects on sperm motility characteristics and bovine cervical mucus penetrability (BCMP). Sperm motion parameters were assessed by computer-assisted motion analysis (CASA) using HTM-IVOS and BCMP was evaluated using the Penetrak kit. In vitro incubation with PTX (1 mg ml-1; 3.6 mM, 30 min) did not significantly change percentage motility, average path velocity (VAP), straight-line velocity (VSL) or beat cross frequency (BCF) of spermatozoa from normozoospermic or asthenozoospermic samples. However, it significantly increased curvilinear velocity (VCL), amplitude of lateral head displacement (ALH) and hyperactivated motility (HA), and significantly decreased linearity (LIN) of spermatozoa from both samples. Pentoxifylline was found to increase BCMP scores for spermatozoa from asthenozoospermic samples, but did not affect scores for spermatozoa from normozoospermic samples. Bovine cervical mucus penetrability (BCMP) was found to be positively and significantly correlated with the percentage motility of both non-PTX-treated and PTX-treated spermatozoa for asthenozoospermic samples. These results demonstrated that PTX enhanced several motion sperm parameters as well as BCMP in asthenozoospermic samples and suggest a potential use of the methylxanthine in infertile patients with motility defects undergoing artificial insemination. PMID- 9949884 TI - Lipid peroxidation in human spermatozoa and maintenance of progressive sperm motility. AB - Washed and deep frozen spermatozoa of 46 patients from an infertility clinic were separated into 3 different groups depending on their progressive motility (expressed as the sperm motile efficiency index according to Ishii et al., 1977), determined 0 and 3 h after liquefaction, and were examined for their lipid peroxidation (LPO) potential by means of the thiobarbituric acid assay. Spontaneous and iron-catalysed generation (after 15, 30 and 60 min incubation) of thiobarbituric acid-reactive substances (TBARS) was measured spectrophotometrically. Spontaneous LPO revealed the highest generation of TBARS in the group of spermatozoa with initially normal progressive motility and decreased maintenance of progressive motility after 3 h of aerobic incubation. Iron-catalysed LPO generally revealed the highest amounts of TBARS after 60 min, especially in the aforementioned group with decreased motility maintenance. The differences between this group and the two other groups were highly significant. Consequently, spermatozoa with initially normal progressive motility but decreased maintenance of motility, generated higher amounts of stable LPO products than others, which suggests that loss of motility under aerobic incubation seems to be the consequence of enhanced LPO processes. PMID- 9949885 TI - Morphometrical comparison of human spermatozoa obtained from semen and swim-up methodology. AB - Because morphology is regularly established in semen smears, but not in swim-up spermatozoa, we were interested in comparing some morphological parameters of semen and swim-up spermatozoa to establish if the cells selected by the swim-up method were morphologically similar to those considered normal in semen. Normal human semen samples were divided into two aliquots. One of these aliquots was washed by centrifugation with B2 medium and sperm smears were prepared with the resulting pellet as a control. The other aliquot was used to perform swim-up separation and the spermatozoa from the supernatant were used as experimental smears. Both groups were stained according to the triple stain technique and spontaneous acrosome reaction and viability were determined. Video microscopy and computer-assisted image processing of live and non-reacted sperm cells were used to establish morphometrical parameters of the sperm head in both populations. The following set of morphometrical parameters were considered: width, length, width/length ratio, acrosome area, head area, and acrosome area/head area ratio. An increase in head width, a decrease in head length and a subsequent increase of width/length ratio were found in swim-up cells compared with the control group. A slight increase in acrosome area/head area ratio was also observed in swim-up supermatozoa. Through the swim-up methodology we were able to select a subpopulation of oval shaped heads with spermatozoa having a bigger acrosome area in comparison to semen. PMID- 9949886 TI - Treatment-related stresses and depression in couples undergoing assisted reproductive treatment by IVF or ICSI. AB - The purposes of the study were to compare treatment-related stresses of couples undergoing IVF or ICSI treatment (ejaculated, epididymal or testicular spermatozoa) and to identify sex differences and risk factors for depression. A one-year cohort of couples was retrospectively sent questionnaires on infertility and treatment-related distress and depression (Depression Scale, D-S). Two hundred and eighty-one women and 281 men (61% of those eligible) were included. As determined by analysis of the medical charts, successful couples were more likely to participate. Treatment-related distress was generally higher for women than for men. Treatment by ICSI carried additional burdens for the men: they reported a greater subjective responsibility for the infertility, impact of childlessness on daily life, treatment-related stresses (particularly for MESA/TESE) and time demands. Even when clinical differences between treatments (e.g. age, previous treatments) were controlled statistically, depression scores did not differ. Independent of the treatment, women were significantly more depressed than their age-matched female controls from the general population and their husbands. The men only reported marginally elevated depression scores compared to their controls. Meaningful characteristics were identified that could guide clinicians to give psychological support to those couples at risk for depression, e.g. an unsuccessful treatment outcome, repeated treatment cycles, a low socioeconomic status, foreign nationality, or, for women, a lack of partner support. PMID- 9949887 TI - Localisation of enzymes in live spermatozoa by CellProbe reagents (preliminary results). AB - As a new approach, various synthetic fluorogenic substrates, the CellProbe reagents, were applied to examine the topography of their cleavage in vital human spermatozoa. These substrates are able to enter the cells without requiring previous cell permeabilization and can produce a fluorescent dye after cleavage, depending on enzyme activity. Vital spermatozoa from samples with normal spermiogram parameters showed fluorescence in different areas and intensity after incubation with a variety of substrates for aminopeptidase A, peroxides, subtilisin, dipeptidylpeptidase IV (DPP IV), cathepsin D, glucosidase and glucuronidase, but not with the substrate for galactosidase. Fluorescence was mainly located in the acrosomal cap (substrates for DPP IV, subtilisin, cathepsin D, glucosidase and glucuronidase) in the middle piece and head (substrates for peroxides, glucosidase), in the sperm head (substrates for aminopeptidase A) and occasionally in the tail (substrate for glucosidase). The substrate for subtilisin may play a role in andrology, because subtilisin is a serine protease like acrosin. This substrate may possibly be used to determine the acrosin activity in vital spermatozoa. The CellProbe reagents for fluorescence cytoenzymology may serve advanced methods in both clinical andrology and spermiological research, presuming that the characteristics and qualities of the synthetic substrates are correct. Therefore, more extended studies will be necessary to determine their clinical utility and significance under physiological and pathological conditions. PMID- 9949888 TI - Direct effect of alcohol on the motility and morphology of human spermatozoa. AB - Excessive alcohol consumption has been associated with impaired reproductive function by causing the inhibition of penile tumescence and ejaculatory capability. Alcohol intoxication has also been implicated in impaired spermatogenesis and an increase in sperm structural anomalies. The aim of this study was to determine the direct effects of alcohol on sperm motility and morphology in vitro. Semen samples from 67 subjects were prepared using density centrifugation. Ethanol was added, at concentrations in serum equivalent to social, moderate and heavy drinking, to the medium in which the spermatozoa were cultured. Sperm motility was assessed using computer assisted semen analysis and morphology was assessed by Tygerberg strict criteria after 0, 15, 30, 60, 120, 180 and 240 min exposure. Each concentration of ethanol produced significant decreases in the percentage progressive motility, straight line velocity and curvilinear velocity. The amplitude of lateral head displacement was also depressed by 300 and 500 mg dL-1 of ethanol. A significant decrease in the number of spermatozoa with normal morphology and an increase in irreversible tail defects were observed after exposure to 300 mg dL-1 ethanol. When alcohol is added directly to sperm, at concentrations equivalent to those in serum after moderate and heavy drinking, damaging effects are observed in both sperm motility and morphology. PMID- 9949889 TI - Laser-assisted cryopreservation of single human spermatozoa in cell-free zona pellucida. AB - Improved procedure for efficient cryopreservation of single human spermatozoa in cell-free human zona pellucida is reported. We used a diode laser system for efficient and precise creation of a single hole into the zona pellucida of a degenerated or immature human oocyte. This allowed the extraction of the cytoplasm using a micropipette with a diameter of 10-15 microns. Through the same opening, human spermatozoa were inserted into the empty zona. We used motile and laser immobilized spermatozoa. Immobilized sperm were obtained by a single laser irradiation delivered in the vicinity of the sperm tail prior to insertion. This new immobilization procedure was shown to have no deleterious effect on membrane integrity and sperm viability. Following sperm transfer into the zona, the laser drilled hole was closed with an oil droplet which was expelled from the micropipette during withdrawal to avoid loss of spermatozoa. This facilitated detection of the otherwise translucent zona during the cryopreservation procedure. After thawing, all cryopreserved zonae (20/20) could be successfully retrieved. Spermatozoa were recovered from the zona pellucida through the hole used for insertion. The rate of sperm recovery for initially motile spermatozoa was 80% vs. 92% for laser immobilized spermatozoa. Sperm viability was 81% and 84%, respectively, detected by a Hoechst stain. This technique makes cryopreservation of single human spermatozoa easy and feasible and appears beneficial for couples with severe male infertility and for those facing repeated surgical sperm extraction. PMID- 9949890 TI - Conception rate after treatment of male idiopathic infertility with pure human follicle stimulating hormone. PMID- 9949891 TI - [Pituitary adenylate cyclase-activating polypeptide]. AB - Pituitary adenylate cyclase-activating polypeptide (PACAP) has been originally isolated from the sheep hypothalamus on the basis of its ability to stimulate cAMP formation in anterior pituitary cells. Post-translational processing of the PACAP precursor generates two biologically active molecular forms, PACAP38 and PACAP27, and a novel peptide called PACAP-related peptide whose activity remains unknown. The primary structure of PACAP has been remarkably conserved during evolution, from protochordates to mammals, suggesting that the peptide exerts important activities throughout the vertebrate phylum. The sequence of PACAP27 exhibits substantial similarities with those of vasoactive intestinal polypeptide (VIP), glucagon and secretin. The gene encoding the PACAP precursor is widely expressed in the brain and in various peripheral organs, notably in endocrine glands, the gastro-intestinal and uro-genital tracts and the respiratory system. In vivo and in vitro studies have shown that PACAP exerts multiple activities as a hormone, neurohormone, neurotransmitter or trophic factor. For instance, PACAP triggers the release of insulin and glucagon, activates steroidogenesis in the adrenal gland and gonads, and stimulates the secretion of most hypophysial cells. PACAP exerts a potent relaxant activity on smooth muscle fibers in blood vessels, lung and gut. In the brain, PACAP stimulates the electrical activity of various populations of neurons and increases tyrosine hydroxylase gene expression. Recent studies have shown that PACAP exerts a trophic activity during ontogenesis, notably in the adrenal medulla and in the central nervous system. The biological effects of PACAP are mediated through three distinct receptor subtypes which exhibit differential affinities for PACAP and VIP. The PAC1 receptor, which shows high selectivity for PACAP, is coupled to several transduction systems. In contrast, VPAC1 and VPAC2, which bind with the same affinity PACAP and VIP, are mainly coupled to the adenylyl cyclase pathway. The bronchodilatator and vasorelaxant effects of PACAP, as well as the antiproliferative and neuroprotective actions of the peptide, make it a valuable target for new drug development. PMID- 9949892 TI - [Treatment of diabetes insipidus with Minirin. Switch from nasal to oral administration]. AB - DDAVP (desmopressin, Minirin is now available in tablet form. We studied the switch from nasal to oral administration in patients taking DDAVP for diabetes insipidis. A retrospective analysis included 56 patients. Mean nasal dosage was found to be 20.4 micrograms desmopressin and mean oral dosage was 417 micrograms. This gave a dosage ratio of about 20, in agreement with current data on the drug's bioavailability. In addition, the daily dose was fractioned more often with oral administration than with nasal administration. This study prepares the way for a prospective study needed to better define the conditions for oral administration of DDAVP (Minirin). PMID- 9949894 TI - [Delayed puberty (in a boy)]. PMID- 9949893 TI - [Biological and clinical safety of nomegestrol acetate administered alone then associated in inverse sequence with transdermal 17 beta estradiol, in women at risk of dyslipoproteinemia type IIa]. AB - In this study including 26 patients with dyslipoproteinemia classified IIa, we evaluated biochemical and clinical safety of Nomegestrol acetate (Lutenyl) used for its antigonadotrophin property. It was administered alone, during 3 cycles at the dose of 5 mg/d for 21 days by cycle and then it was associated (at the same sequence and dose), without any wash out, for the next 6 cycles, with a 17 beta estradiol patch (Estraderm TTS 50), 50 micrograms/d from the 11th to the 21st day of each cycle. Nomegestrol acetate, alone, had no significant effect on glycemia, antithrombin III, triglycerides, total cholesterol, apoprotein A1, and LpA1 values compared to those at baseline but apoprotein B and Lp (a) values tended to decrease slightly. Serum progesterone levels were collapsed, and FSH values were low. Weight and blood pressure remained constant. Adding 17 beta estradiol enabled to significantly decrease and normalize the apoprotein B values after the first 3 cycles compared to the baseline values, then these values remained constant during the next 3 cycles. There was no effect on the other parameters (except for a significant increase in plasmatic estradiol values) on the antigonadotrophin property of Nomegestrol acetate, nor on weight and blood pressure which remained constant. Moreover, we observed an important decrease in the rate of amenorrheic cycles compared to those with Nomegestrol acetate alone. PMID- 9949895 TI - [Acromegaly: retrospective study of 104 patients]. PMID- 9949896 TI - [A comparative study of the evolution of atherosclerosis in men over a 25-year period in 11 European and Asiatic cities]. AB - Repeated epidemiologic study of atherosclerosis in males on the basis of autopsy material with 25-year interval (1963-66 and 1985-89) has been performed in 7 European cities (Malmo, Praha, Riga, Tallinn, Tartu, Kharkov, Yalta) and 4 Asia cities (Ashkhabad, Bishkek, Irkutsk, Yakutsk). Accelerated development of atherosclerosis in the 2nd study has been revealed in males in the majority of cities except Malmo and Praha. No significant differences in atherosclerosis of aorta and coronary arteries were found in these two cities. An increase of the calcinosis surface in the coronary arteries combined with a higher incidence of coronary stenosis was typical for the 2nd study. Atherosclerosis was less pronounced in the indigenous population of Ashkhabad, Bishkek and Yakutsk in both studied than in non-indigenous populations. There was a positive correlation in males between lethality of coronary heart disease and other cardiovascular diseases and the degree of coronary atherosclerosis. Thus, the course of atherosclerosis can change within the life of one generation. PMID- 9949897 TI - [The role of hyperplasia of the arterial intima in human atherogenesis]. AB - Arteries predisposed and resistant to atherosclerosis development were studied. Arteries predisposed to atherosclerosis show a high degree of intima hyperplasia and various alterations of elastic structures. Hyperplasia of the vascular intima followed by disturbance of plasma perfusion through the arterial wall and increase of its cellularity (lymphocytes, monocytes/macrophages) determines possibility of atherosclerosis development (crucial factor of atherosclerosis pathogenesis) in man. Accumulation of lipids in the intima occurs not only in pronounced disturbances of lipid metabolism but at its "normal" indices as well this resulting in atherosclerosis development in all members of the population. PMID- 9949898 TI - [The morphology of the myocardium in the Wolff-Parkinson-White syndrome]. AB - Myocardium of the right atrium from 5 patients with the above syndrome was studied at the light and EM level. Apoptotic degeneration of myocytes was demonstrated for the first time. The alterations observed may be secondary and due mainly to microcirculatory disturbances produced by tachyarrhythmia which appear during the excitation waves circulation. Metabolic changes and ischemization of myocytes may trigger the program of cell death (apoptosis) this aggravating the myocardium state and producing widespread fibrosis. These changes may serve a cause of lethal arrhythmia and sudden death of patients. PMID- 9949899 TI - [Destructive changes in the mitochondria of human cardiomyocytes in alcoholic heart lesion]. AB - Destructive changes in cardiomyocyte mitochondria of patients with diagnosis of alcoholic heart lesion were observed by the ultrastructural analysis of the endocardial biopsies serial sections. The appearance of mitochondria with the third additional compartment and mitochondria having two zones of different electron density not separated into the special compartments are described for the first time. The development of megamitochondria having different morphology is demonstrated. Mitochondrial origin of lipophuscin granules is suggested on the basis of the ultrastructural changes. Unusual structure of atypical mitochondria may provide new properties of these organelles this being considered by the authors as an adaptive cell and mitochondria response to the new metabolic conditions. PMID- 9949900 TI - [A quantitative analysis of the ultrastructures of the blood polymorphonuclear neutrophils in patients with ischemic heart disease after a session of intravenous laser therapy]. AB - Circulating neutrophilic granulocytes before and after laser therapy were studied in 10 patients with ischemic heart disease and 5 healthy persons. The patients had severe cytoplasm vacuolization, specific granules number increase, a decrease in thickness of the submembranous actin layer and decrease of surface = volume ratio. Neutrophils indices in patients with ischemic heart disease become closer to those in donor cells after blood irradiation with a helium-neon laser. The results indicate a normalizing effect of helium-neon laser irradiation on the mechanisms of non-specific reactivity in some forms of ischemic heart disease. PMID- 9949901 TI - [The status of the heart and coronary artery bed in experimental subclavian pulmonary anastomosis and after its removal]. AB - Subclavian-pulmonary anastomosis was made in 33 young dog. In 15 dogs anastomosis was ligated and they were sacrificed 1 year after the surgery. The anastomosis was shown to result in the adaptive and pathologic restructurization of the heart and its vascular bed. The former consists of the myocardial hypertrophy, coronary arteries hyperplasia and hypertrophic-hyperplastic alterations of their walls muscles. The latter manifested with angio- and cardiosclerosis. Anastomosis elimination initiates the process of reversibility of alterations that appeared earlier. PMID- 9949902 TI - [The importance of a new classification of chronic glomerulonephritis for determining the prognosis of the disease]. AB - Dependence of chronic glomerulonephritis upon its clinical type was studied on the basis of observation in 165 patients of chronic renal failure incidence during 7 years after the beginning of the disease. PMID- 9949903 TI - [The pathomorphology of the kidneys in the fetuses of mothers suffering from late gestosis, type-1 diabetes mellitus and chronic glomerulonephritis]. AB - Fetal kidneys from mothers with late gestosis, diabetes mellitus-1 and chronic glomerulonephritis were studied. There were features of the maturation slowing down and some disturbances in differentiation of rental tissue were revealed. Local degenerative, membranous, proliferative and fibroplastic changes with formation of immune complexes including IgM and C3-complement in late gestosis, IgA, G, C3-complement fractions IgG, M, C3-complement fraction and traces of membranous and proliferative alteration were observed in chronic glomerulonephritis, they were less frequent in diabetes mellitus in mothers, and not so often in late gestosis. Activation of collagen production of types I, III, IV and V was most commonly observed in diabetes mellitus, in chronic glomerulonephritis and late gestosis, it being more rare. PMID- 9949904 TI - [An evaluation of the degree of the morphological activity and the stage of the process in patients with chronic liver diseases caused by coinfection with the hepatitis B, C and/or D viruses]. AB - In order to determine the differences in histological grade of activity and the stage of fibrosis in patients with chronic liver diseases due to multiple hepatitis virus infection and single infection of HBV and HCV we assessed the 68 liver biopsies samples according to Knodell and Scheuer scoring systems. Retrospectively, 216 liver biopsies reports from consecutive patients with chronic viral hepatitis were analysed. Histological activity index (HAI) in HBV/HCV coinfection was higher than in a single HCV infection; it did not differ in groups of HBV/HBC and HBV. The difference was due to the interface hepatitis; lobular activity and portal inflammation were the same. In HDV superinfection HAI was high due to both portal-periportal and lobular hepatitis. HAI depended mainly upon the presence of HBV replication; in patients with chronic hepatitis C with HBV-DNA HAI was also higher than in single HCV group. No difference in HAI between triple and dual hepatitis virus infection was found. In patients with HBV/HCV coinfection and especially with HDV superinfection the advanced stages occurred more than often than in patients with single infections. PMID- 9949905 TI - [An immunohistochemical study of the expression of the epithelial antigen Ber-EP4 and other tissue-specific antigens in primary and metastatic brain tumors]. AB - The expression of the Ber-EP4 epithelial antigen is shown to be a valuable criterion for differential diagnosis of primary and metastatic brain tumors. An important role for immunological typing of brain tumors belongs to verification of the acid glial fibrillar protein, synaptophysin, vimentine, common leucocytic antigen and melanoma HMB-45 antigen. The use of the above antibodies spectrum is most valid both for differential diagnosis of metastatic and primary brain tumors and for specification of histogenetic origin of different poorly differentiated intracranial tumors. PMID- 9949906 TI - [An ultrastructural analysis of the postmortem changes in the sinoauricular area of the canine heart]. AB - The EM study of all tissues and myocyte components in the sinus node (SN) and adjacent working myocardium of the right atrium was performed in normal dogs and in dogs 1, 2, and 3 hours after death. A quantitative evaluation of the myocyte density, connective tissue components, vessels and nerve fibers in the SN and working myocardium of this region was performed. Destructive changes having mosaic appearance were observed in the conducting and working myocytes, myelinated and non-myelinated, nerve fibers, in vessels and partly in components of connective tissue of both SN and working myocardium. Possible mechanism of development of the ultrastructural pathology in the sinoauricular region of the heart during autolysis are discussed. PMID- 9949907 TI - [Malignant lymphoproliferative lesions of the trachea]. AB - Detailed review of literature and analysis of 4 authors's cases of the trachea non-Hodgkin lymphoma and lymphogranulomatosis are presented. PMID- 9949908 TI - [A comparative density gradient analysis of the smooth myocytes of different internal organs]. AB - Method of the bronchi and colon smooth myocytes dissociation in living rats with separation of cell fraction in the density gradient is worked out. Precise parameters of relative density of the bronchi and colon muscle cells are established. Smooth myocytes being a part of different organ-systems are shown to be characterized by different parameters of relative density. PMID- 9949909 TI - [The founder of a clinico-experimental direction in pathology A. B. Fokht (1848 1930): on the 150th anniversary of his birth]. PMID- 9949910 TI - [Atherogenesis and the acute-phase reaction of the liver]. AB - Data from literature are given on the role of "acute phase" proteins in inflammation and their connection with lipoproteins. Intensive production of acute phase proteins is shown to take place in modelling of experimental atherosclerosis. The hypothesis is proposed that allows to consider the acute phase reaction of the liver as a very important condition of modified lipoproteins formation acquiring autoantigenic properties. PMID- 9949911 TI - Historical aspects of complementary medicine. PMID- 9949912 TI - Acupuncture in dermatology. PMID- 9949913 TI - Aromatherapy in dermatology. PMID- 9949914 TI - Bioclimatology and balneology in dermatology: a Dead Sea perspective. PMID- 9949915 TI - High mountain climatotherapy. PMID- 9949916 TI - Biofeedback, cognitive-behavioral methods, hypnosis: "alternative psychotherapy"? PMID- 9949917 TI - Biofeedback in dermatology. PMID- 9949919 TI - Hypnosis in dermatology. PMID- 9949918 TI - Cognitive-behavioral techniques. PMID- 9949920 TI - [Approach of psychology to health]. PMID- 9949921 TI - [Iatrogenic psychopathology and cancerology]. PMID- 9949922 TI - [Bearing witness. "To pretend"]. PMID- 9949923 TI - [Psychological aspects of cancer in the child]. PMID- 9949924 TI - [Diagnostic disclosure. Psychological impact and practical aspects]. PMID- 9949925 TI - [Measure of negative life events before onset of cancer]. PMID- 9949926 TI - [The case of Colette D. 59 years of age, representative, 2 children, and without any medical problem until....]. PMID- 9949927 TI - [Listening to the moment or the communication is lost]. PMID- 9949928 TI - [Images and representations of cancer]. PMID- 9949929 TI - [Cancer and depression: epidemiologic aspects]. PMID- 9949930 TI - [Anxiety, depression, cancer: clinical aspects]. PMID- 9949931 TI - [Depression and cancer: therapeutic aspects]. PMID- 9949932 TI - [Interaction of psychological and social factors in the care of AIDS virus carriers]. AB - This clinical study of social issues focuses on the interaction of psychological with social factors that affect the behavior toward the care in AIDS. This first part of the research concerns the nurses' representations and the nurses' unconscious suffering in work. The analysis of twenty interviews and twenty five days of observation in an hospital shows that: the work environment is created, partly based on individual psychological problems and interactions of their representation of care with the organizational necessities; the principal nurses' representation of care concerns an idealization of a good familial world they have not themselves; their interpersonal familial disturbances are compensated for their work investment; however, these familial idealisations of care hide their work suffering and patients have to adapt to the nurses' representation otherwise they will be thrown back. PMID- 9949933 TI - [Consent: between legality and legitimacy or between "formal" and "informed" consent]. AB - As shown by a recent decree of the supreme court, the legal aspect of information given before consent is more and more important. At beginning, the written consent was reserved to particular cases, as biomedical research for example. It concerns now all the fields of care, since it is considered as a proof of the existence of a prior information. The informed consent changes in a formal consent: the consequence is a modification of the relation between the physician and the patient. We may imagine that this evolution paradoxically results in a worse integration of subjectivity. Then, it seems necessary to stress the clinical aspect so as to give to the consent concept its legitimity back: it consists in an ethical and humanistic acknowledgement of alterity. PMID- 9949934 TI - [Psychiatric hospitalizations after the June 27 1990 Law in a French department]. AB - The law, edicted on the 27th june 1990, has introduced in France the without consent hospitalization, to replace the law of 30th june 1838 which was composed of confinements or psychiatric placings. On of the both new types of a without consent admission, called "by a third person request" hospitalization (HDT) containing a procedure called "usual" and another one called "situation emergency", appeared to us more and more used in our practice, particularly the "situation emergency" HDT. Therefore we compared on three periods, one before the law, the two others ones 3 and 6 years after it, the different types of psychiatric admissions in all of the seven psychiatric sectors of a french department. All the hospitalization's forms increase with the chronologic time in Cote d'Or. We notice too in this department an important increase of the HDT, but especially in the "situation emergency" ones, and this, with a statistically revealing way compared to the other types of admission. If this phenomena wasn't purely localized, which only the departmental commissions of psychiatric hospitalization, created by the 1990's law, can reveal by proceeding to an expected assessment of the law consequences, the legislator should fastly take this evolution into account. PMID- 9949935 TI - [Multicenter trials in the treatment of depression: some methodological issues]. AB - In recent year, multicenter psychopharmacological trials have met an increasing interest since through them it has become easier, in a relatively short time, to collect large samples of patients. Methodological problems common to all psychopharmacological trials may be sharpened in this kind of investigation. Others, that are specifically related to multicenter studies, may also arise. Methodological difficulties addressed in this paper are those related to patients selection procedure, to strategies for data analysis and to issues about design or management of the study. Strictly speaking, the results of a such a trial could only be generalised to patients exhibiting the characteristics of the studied sample. Moreover, before pooling the data obtained at each center, preliminary analyses should demonstrate that centers do not differentiate themselves on the basis of patient characteristics. The new drug has to be compared to both a placebo and a reference compound. In this way, and through the replication of the expected difference between the placebo and the reference drug, the methodological validity of the trial could be ascertained. The treatment with a placebo is warranted by the facts that illness natural course and non specific treatment effects have to be taken into account. Satisfactory levels of inter-rater reliability have to be achieved and maintained through training sessions with the participation of all the centers involved in the trial. Statistical analyses generally focus on the intent to treat sample. However, due to the delayed activity of antidepressant drugs, efficacy analyses could be limited to patients treated at least 14 days. Multivariate analysis of variance is particularly well suited for data analysis but can be invalidated by an excess of dropouts. To overcome this problem, other techniques such as survival analysis and random regression models have been proposed. This latter procedure seems to be particularly promising for analysing data of multicenter trials since it can assess treatment difference while adjusting for inter-center variability. PMID- 9949936 TI - [Depression scales in schizophrenia: a critical review]. AB - Depressive syndromes frequently occur during the evolution of schizophrenia. The evaluation of depression in schizophrenic patients is difficult because of an overlap between depressive, negative and extrapyramidal symptoms. The scales usually employed to evaluate depression have not been validated in schizophrenic populations, therefore, some authors developed specific depression scales for schizophrenics. In this work, we present the available data about the metrologic and psychometric properties of the Hamilton (HDRS), Montgomery Asberg (MADRS) and Widlocher (ERD) depression scales in schizophrenic populations. We further present the validation works of the Psychotic Depression Scale (PDS) and the Calgary Depression Scale (CDSS). Non specific depression scales are unsatisfactory, since negative and extrapyramidal symptoms overlap with depressive symptoms. The ERD allows a distinction of the three symptom groups, when motor, ideic and subjective subscores are used. The two specific scales actually distinguish depression with a minimal level of contamination. Nevertheless, the factorial structure of the PDS comprises several non depressive factors that are of questionable interest. The CDSS is a well documented and validated tool, with an unidimensional structure, a good internal consistency, a high inter-rater reliability, and good external validity and specificity. PMID- 9949937 TI - [Further clinical evaluations elicited by functional biological investigations in childhood autism]. AB - As childhood autism is usually considered as a developmental disorder, complete assessment of each patient requires non only clinical examination but various biological investigations: EEG and evoked potentials recordings, biochemical dosages and sometimes, cerebral blood flow measures, molecular biologic explorations.... These investigations help to understand neurophysiological dysfunctionings which underly different autistic syndromes. It therefore seems necessary to develop quantified clinical tools which could allow closer matching between clinical evaluations and biological numerical data. These complementary evaluations must be both simple and quick to perform in medical practice, as they are added to an already heavy clinical examination. The main tools used in our bioclinical Department are described here. For each child, psychiatric, pediatric and neurological examination was performed. Different scales were progressively elaborated and validated to complete and precise behavioral parameters. Attention and perception were evaluated by a Behavior Summarized Evaluation (BSE) scale, association and imitation by appropriate scales, language by the Pre-Verbal Behavior Summarized Evaluation (PV-BSE) scale, early symptoms by the Infant Behavior Summarized Evaluation (t-BSE) scale. The main neurophysiological dysfunctionings were grouped in a Behavioral Functional Inventory (BFI). Clinical genetic data were scored in a summarized assessment carrying both on the antecedents and on the somatic abnormalities. The completed clinical data were gathered in a Quantified Multidimensional Assessment (QMA), with four axes: socialization, communication, cognition and neurological observation. These clinical evaluations provide behavioral details that can be integrated into a bioclinical database and give an objective approach to the heterogeneity of autism. They invite both clinicians and biologists to deepen the description of individual profiles which allow better understanding of physiopathological mechanisms in autistic children. PMID- 9949939 TI - [Stress and anxiety: what are they?]. AB - Although anxiety and stress were two distinguished concepts, they were used confusedly by medical and psychological talks. Whereas anxiety is currently a well-known psychopathological notion, stress remains blurred and unclear. The aim of the study was of course to exhibit the relationships between stress and anxiety, but also to show by which mechanisms anxiety would have a role in the stress-response modulation. Three groups of subjects, paired in age and sex, were compared: 28 paid controls (13 male) aged 37 +/- 12 years, 25 subjects (12 male) aged 38 +/- 8 who consulted in a framework of CITES Prevert (clinic of stress) but without mental disorders, and 28 subjects (13 male) aged 37 +/- 12, out patients suffering from anxiety disorders (generalized anxiety disorders according to DSM IV). All of subjects were drug free when examined. They were submitted to auto-evaluation psychological tests: Amiel-Lebigre life events, Spielberger anxiety trait and state, Plutchik and Van Praag depression and finally Chapman anhedonia. After that, two ERPs were recorded, the P300 by using the classical "Oddball experimental paradigm" in auditive modality and the Contingent Negative Variation (CNV) by using a reaction time task with warning stimulus. A close relationships between stress and anxiety could be an evidence as showed by the positive correlations between life events and psychological data (anxiety and depression). In addition, the results displayed correlations between anxiety trait and CNV reaction time (positive correlation) and early P300 (P3a) component amplitude (negative correlation). This could support the hypothesis according to the anxiety would disturb the behavior (slow motor response) and the cognitive processes (attentional changes), and therefore would have a role in the stress-response modulation. Nevertheless, anxiety trait were not correlated to the late P300 component (P3b) amplitude, thus to controlled attention processes. Moreover P3b amplitude were reduced exclusively in subjects who suffered from anxiety disorders. This could mean that anxiety trait would not be solely involved in cognitive changes. Pathological states, as anxiety disorders, could involve another logic of the mental functioning. These results will be discussed according to the cognitive psychology and psychophysiology knowledges. PMID- 9949938 TI - [Basic cognitive-perceptive module in schizophrenics]. AB - A specific deficit in gaze discrimination has been hypothesized for schizophrenic patients (Rosse et al., 1994). Gaze discrimination is a basic ability for animals as well as for human beings. It plays an important role in mutual control of social interactions. According to Baron-Cohen (1995), sensitivity to eye gaze relies on a specific cognitive module, the Eye Direction Detector (EDD). The author distinguishes three basic functions of the EDD; first, the EDD is involved in eyes detection; second, the EDD is used in order to establish direction of gaze, and specially to compute whether the eyes one is looking at are directed to the subject or somewhere else; third, the EDD is implied in interpretation of gaze as seeing. Rosse et al. (1994) tested subjective impressions concerning gaze discrimination in a group of schizophrenic patients. Schizophrenics reported the subjective impression of being looked at by the portraits significantly more often than controls. The authors concluded that a specific impairment in gaze detection is present in the patients, and that it may be responsible for the paranoid symptoms often reported in schizophrenia. However, it seems difficult to assert that a response bias in schizophrenics toward perceiving faces as looking at them results from the deficit of an elementary perceptual module responsible for the detection of eye-direction. Rather we suspect such a bias to be the consequence of an impairment of the more complex level of mindreading, responsible for the interpretation of gaze as seeing in terms of mental states. The aim of the present experiment was to test in a more specific way the elementary gaze discrimination system. A series of portraits of models looking at five different directions (-30 degrees, -15 degrees, 0 degree, 15 degrees, 30 degrees), have been presented to 22 schizophrenic patients and 36 normal control subjects. In each trial one portrait was presented. Subjects were asked to determine the direction of its gaze by pressing the "z-key" (left side of the keyboard) if the portrait was looking to the left, and the "/-key" (right side of the keyboard) if the portrait was looking to the right. For each trial, we recorded both the side of the response (left key or right key) and the corresponding reaction time (RT). For the purpose of the analysis, the mean numbers of left responses were computed for each subject. The mean numbers of left responses recorded for each direction of gaze did not significantly differ between patients and controls. That is schizophrenic patients are not impaired in the gaze discrimination task used in the present study. In Rosse's experiment, subjects were required to decide whether the portrait on the screen was looking at them or not. On the contrary, in our task, subjects were simply required to state whether gaze was directed to the right or to the left. No explicit judgment was required as to whom or what gaze was directed. Therefore, we can assume that the present paradigm investigated the functioning of a more basic process than that tested by Rosse et al. Our data are consistent with those reporting that basic cognitive processes are unimpaired in schizophrenia, whereas explicit processes are extensively affected. PMID- 9949940 TI - [Treatment of adjustment disorder with anxiety: efficacy and tolerance of etifoxine in a double-blind controlled study]. AB - Adjustment disorder with anxiety is defined as a clinically significant anxiety that occurs within 3 months after the onset of an identifiable psychological stressor. Recent studies indicate that this disorder is not uncommon and must be quickly identified and treated. However, few therapeutic trials have been done in relation with this disorder. According to the criteria set by DSM IV, 170 patients with a primary diagnosis of adjustment disorder with anxiety have been enrolled in a double blind multicenter controlled trial. Patients were treated for 4 weeks with etifoxine (150-200 mg/d), or buspirone (15-20 mg/d). Also both etifoxine and buspirone show clinical efficacy and safety, the two treatments are not equivalent. The global improvement score and the efficacy index are significantly improved in the etifoxine group. These results show the interest of using etifoxine in the treatment of adjustment disorder with anxiety and should be confirmed by further studies. PMID- 9949941 TI - [Pharmacological approach to failures of antidepressant treatment]. AB - Depression, a chronic disease and a leading cause of disability worldwide, will generate increasing needs in terms of public health in the coming years. Many antidepressants are now available. However, these molecules present real limitations and disadvantages. Thus there are great expectations on the part of the clinicians for more efficient drugs that are better tolerated. How can we satisfy such hopes and innovate in this domain today? One original and most promising strategy for developing new antidepressants that are more efficient and better tolerated involves antagonizing both alpha 2-noradrenergic and 5HT2 and 5HT3 serotonergic receptors, without blocking 5HT1A serotonergic receptors. The technology now available in pharmacological research allows the development of such molecules. PMID- 9949942 TI - [Risperidone-induced tardive dystonia: a case of torticollis]. AB - Tardive dystonia is one of the most serious adverse events of typical neuroleptic treatments. They differ from tardive dyskinesia by their clinical and evolutive features. The occurrence of tardive dystonia due to new antipsychotics remained unknown. For the first time in the literature, we report a case of typical tardive dystonia occurring in a young male schizophrenic patient treated for 8 months with risperidone. No remission was observed despite several therapeutics including botulinic toxin. PMID- 9949943 TI - Differential expression of MHC class II genes in lung tumour cell lines. AB - Molecular characterization of HLA class II expression was investigated in five lung tumour cell lines at the protein and mRNA levels. The cell lines exhibited a differential expression of HLA-DR, HLA-DP and HLA-DQ products and also showed differences in the inducibility of HLA class II genes by gamma-IFN. Gamma-IFN stimulation induced only HLA-DR expression to varying degrees in three cell lines, while only one cell line showed stimulation for HLA-DP and none for HLA-DQ antigens. These results suggest locus-specific regulation for the three loci. The presence of DR protein on the cell-surface membrane was always positively correlated with the presence of HLA-DR mRNA in the cells. After treatment with 5 azacytidine in the A549 cell line, which expressed the lowest values, there was no effect on HLA class II levels. This suggested that methylation does not play an important role in the lack of MHC class II antigen expression. In addition to studying mRNA levels of HLA class II antigens, we analysed mRNA of the proto oncogene c-myc and observed a positive correlation of two mRNA: the increments in HLA-DR expression were associated with increments in c-myc expression. This suggests a relationship between the regulatory and HLA-DR antigens control the expression of c-myc and HLA-DR antigens in lung tumour cell lines. PMID- 9949944 TI - Functional characterization and exon 2-intron 2-exon 3 gene sequence of HLA B*2712 as found in a British family. AB - The HLA-B*27 group of alleles has been extensively studied due to the association of particular B*27 alleles with ankylosing spondylitis (AS). We describe here an HLA-B*27 allele (B*2712) encoding an antigen that lacks reactivity with B27 monoclonal antibodies (moabs) and alloantisera but reacts with some B40/B60 moabs and alloantisera and expresses the Bw6 public epitope. This allele was discovered by the segregation of an HLA-B allele undetectable by PCR-SSP within a Caucasian family from the British population referred for routine bone marrow transplant HLA typing and found in the haplotype A*29; B*2712; Cw*1203; DRB1*13; DQB1*0603. Serological typing showed a lack of reactivity with four B27 moabs and four alloantisera but positive reactivity with moabs and alloantisera specific for B40/B60 and Bw6 public epitopes. Subsequent sequencing showed the closest homology was with B*2708 with three mismatches in exon 2 at positions 204, 209 and 210. The intron 2 sequence was identical with other B*27 lineage alleles including a 2 base pair deletion at positions 95 and 96. The relationship between HLA-B*2712 and reported B60 associations with susceptibility to AS remains to be determined. PMID- 9949945 TI - Tumour necrosis factor beta gene polymorphisms in myasthenia gravis. AB - Genetic analyses indicate that genes within the major histocompatibility complex (MHC) can be involved in susceptibility to autoimmune disease. To investigate the role of the tumour necrosis factor beta (TNFB) gene in myasthenia gravis (MG) susceptibility, we analysed an NcoI polymorphism within the TNFB gene in 63 MG patients and 93 healthy individuals. When patients were subdivided according to thymic pathology, we found differences between MG patients with thymic hyperplasia and thymoma versus controls. In MG patients with thymic hyperplasia we found a positive association with the TNFB*1 allele [Relative risk (RR): 2.6; P < 0.001] and phenotype (RR: 1.8; P < 0.005) and a negative association with the TNFB*2/2 genotype (RR: 0.2; P < 0.001) when compared to the controls. On the other hand, in MG patients with thymoma we found a positive association with the TNFB*2/2 genotype (RR: 5.6; P < 0.01) and a negative association with the TNFB*1 allele (RR: 0.3; P < 0.05) and *1/2 genotype (RR: 0.2; P < 0.01). These data suggest that the two different forms of MG can have different pathogenesis and that the TNFB gene could influence susceptibility to MG. PMID- 9949946 TI - Description of two Mhc-C-related sequences in the New World monkey Saguinus oedipus. AB - Two new Mhc class I partial exon 1, intron 1, exon 2, intron 2 and partial exon 3 DNA sequences from the New World monkey Saguinus oedipus (Saoe) are described. These two sequences show certain Mhc-C sequence-specific changes. The only difference between these two new sequences is a productive substitution at position 152 [GCG (Ala)-->GAG (Glu)]. This change occurs in a position which in Mhc classical class I molecules affects the interaction between the peptide and the T-cell receptor. A dendrogram with Mhc sequences from different loci and different species was constructed, which clearly shows that these two new sequences cluster closer to Mhc-C sequences than to others. These data suggest that the new sequences may be related to the Mhc-C locus, and they have been named Mhc-Saoe-CR*01 and -CR*02. However, they share only a few of the conserved residues (from gorilla to human) of Mhc-C sequences, which suggests that the relationships with an ancestor of the Mhc-C lineage are very distant or that these two sequences are products of convergent evolution to perform a C locus related function. Furthermore, in the fragment of DNA sequenced, there is a loss of two invariant residues conserved in antigen-presenting molecules from reptiles to humans; thus, it is unlikely that these two Mhc-C-like sequences have an antigen-presenting function, or even that they are two alleles of a pseudogene; however, the G + C percentage (86.1%) at the third base of codons approaches that of an expressed gene in Saoe. It is concluded that Mhc molecules with C-locus characteristics existed in primates 50 million years ago and that this does not support a more recent origin of Mhc-C genes. PMID- 9949947 TI - Two novel biallelic polymorphisms in the IL-2 gene. AB - We have detected two novel single nucleotide polymorphisms in the IL-2 gene, at positions -330 and +166 relative to the transcription start site. The +166 change occurs within the leader peptide and does not affect amino acid sequence. The 330 polymorphism has two common alleles, making it an ideal marker for genetic association studies. PMID- 9949948 TI - The murine Cd48 gene: allelic polymorphism in the IgV-like region. AB - The murine CD48 molecule is a member of the immunoglobulin superfamily which regulates the activation of T lymphocytes. prior cloning experiments using mRNA from two different mouse strains had yielded discrepant sequences within the IgV like domain of murine CD48. To resolve this issue, we have directly sequenced genomic DNA of 10 laboratory strains and two inbred strains of wild origin. The results of our analysis reveal an allelic polymorphism within the IgV-like domain of murine CD48. PMID- 9949949 TI - Nomenclature for factors of the HLA system, update August 1998. PMID- 9949950 TI - Nomenclature for factors of the HLA system, update September 1998. PMID- 9949951 TI - The rotavirus vaccine. AB - BACKGROUND: Rotavirus gastroenteritis is an important cause of morbidity and mortality worldwide. OBJECTIVES: To review the biology, immunology, and virology of rotavirus infections and describe the efforts towards the construction of vaccines using human and animal rotaviruses. STUDY DESIGN: A review of the literature and provision of the author's understanding and speculation of vaccination of infants against rotavirus disease. RESULTS: In August 1998 the Food and Drug Administration in the United States approved the licensure of a rotavirus vaccine. Both the Advisory Committee of Immunization Practices and the American Academy of Pediatrics are likely to recommend that the vaccine be given to all children by mouth as a series of three doses at 2, 4, and 6 months of age. The vaccine is made by combining a simian rotavirus strain (RRV) with several human strains representing different rotavirus serotypes. An understanding of the biology, immunology, and virology of rotavirus will help to explain the strengths and limitations of the rotavirus vaccine. CONCLUSION: If used as recommended, the rotavirus vaccine should cause a significant decrease in the number of deaths, hospitalizations, and office visits of children infected with rotavirus. PMID- 9949952 TI - Comparative evaluation of the use of immunoblots and of IgG avidity assays as confirmatory tests for the diagnosis of acute EBV infections. AB - BACKGROUND: Despite the availability of several different markers for Epstein- Barr virus (EBV) serology, the EBV status of some patients cannot be resolved from a single serum sample with routine testing. To avoid the requirement of follow-up samples, supplementary tests have to be used in these cases. OBJECTIVE: To evaluate the usefulness of avidity and immunoblot assays as supplementary tests for the diagnosis of acute EBV infections. STUDY DESIGN: Three groups of samples for which a definite diagnosis on the EBV status could not be obtained with the routine serological tests were further examined by an EBV IgG avidity assay, by an immunoblot based on a lysate of EBV infected cells, and by a second immunoblot based on recombinant EBV antigens. The three groups consisted of 38 samples with negative/borderline EB nuclear antigen 1 (EBNA-1) antibodies, negative/borderline EBV IgM and positive EBV IgG; 10 samples with indeterminate EBNA-1 and/or EBV IgM assays because of control antigen reactions; and 4 samples with positive EBV IgM results that were not plausible. RESULTS: The avidity assay differentiated between acute and past infections for all samples. In contrast, some cases remained unresolved with both the recombinant and the lysate immunoblot. Two samples were incorrectly classified with the lysate immunoblot. Interpretation of the lysate immunoblot banding patterns was complicated when anticellular antibodies were present. CONCLUSION: Avidity testing appears to be the confirmatory method of choice to differentiate between acute and past EBV infections. PMID- 9949953 TI - Distribution of CD4+ T-lymphocytes levels in patients with clinical symptoms of AIDS in three west African countries. AB - OBJECTIVES: To study the CD4 T-lymphocyte distribution in patients with clinical signs suggestive of AIDS in West Africa. DESIGN AND METHODS: Selected patients had clinical AIDS, according to the WHO clinical definition of AIDS in Africa. Serum samples were tested for the presence of HIV antibodies with two different enzyme immunoassays (EIA), and whole blood was used to determine the CD4 lymphocyte levels of each patient, using the TRAx CD4 Test Kit. RESULTS: In patients with AIDS, the mean CD4+ cell level was 466/microliter; 34% of patients had less than 200/microliter and 62.1% less than 400/microliter. In patients with clinical AIDS but without HIV antibodies, the mean CD4+ cell level was 807/microliter; with 4% below 200/microliter and 14.7% below 400/microliter. The optimal CD4+ cell cut-off between the two groups of patients (with and without antibody to HIV) was 400/microliter. CONCLUSIONS: The mean CD4 cell levels of AIDS patients was more than twice the 200 CD4+ cells/microliter which, alone or associated with clinical criteria is used to differentiate HIV seropositive patients with and without AIDS. A cut-off of 400 T-lymphocyte equivalents per microlitre (TLE/microliter) will be more appropriate. Only 4% of the anti-HIV negative patients had < 200 CD4 TLE/microliter, and could be infected with unknown immunodeficiency viruses. PMID- 9949954 TI - Lack of evidence for an association between TTV infection and severe liver disease. AB - BACKGROUND: In 1997 a new human virus, TTV, was identified. The clinical significance of the TTV infection, however, remains unknown. OBJECTIVE: Establishment of the prevalence of TTV DNA in different population groups in Germany and the assessment of the possible clinical significance of TTV infection. STUDY DESIGN: Detection of the TTV DNA by PCR in blood donors, patients with end-stage liver disease, and multiple transfused patients with haemotological disorders. RESULTS: TTV DNA was detected in 16 of 122 (13.1%) volunteer blood donors, in 34 of 77 (44.2%) patients with end-stage liver disease, and in 21 of 38 (55.3%) multiple transfused patients. There was no difference in the prevalence of the TTV DNA in end-stage liver disease patients with regard to sex, age, presence of HCV and HBV infection markers, and etiology of liver disease. Phylogenetic analysis of the amplified DNA fragments from 12 randomly selected TTV infected subjects demonstrated that in Germany at least two putative TTV genotypes and four subtypes are circulating. CONCLUSIONS: (i) TTV is widely spread in German population; (ii) one of the possible ways of its transmission is blood transfusion; (iii) TTV infection most probably does not generally lead to the development of the end-stage liver disease. PMID- 9949955 TI - Amplicor HIV monitor, NASBA HIV-1 RNA QT and quantiplex HIV RNA version 2.0 viral load assays: a Canadian evaluation. AB - BACKGROUND: HIV-1 viral load quantitation is now recognized as a useful tool to monitor the efficiency of antiviral treatment and a powerful predictor of disease outcome. Three HIV-1 viral load quantitation methods have been currently available as commercial kits in Canada since 1996. OBJECTIVE: To evaluate the ability to quantify HIV-1 RNA in plasma of the Amplicor HIV Monitor Test, the NASBA HIV-1 RNA QT Assay and the Quantiplex HIV RNA Assay, version 2.0, at comparable lower detection limits. STUDY DESIGN: Blood was collected from 50 HIV 1-infected patients at various stages of infection and therapy. CD4+ cell count were estimated by flow cytometry. Plasma was isolated and tested in duplicate on four occasions using viral load kits from a single lot. HIV RNA data, performance, sensitivity and intra- and inter-assay variability were compared. RESULTS: RNA could be quantified in 33 patients by each technique. An inverse correlation was observed between viral load level and CD4+ cell counts in patients with counts below 200. Monitor could detect RNA in 94% of patients, but it showed the greatest variability and failure rate. Quantiplex 2.0 could detect HIV-1 RNA in 78%, and NASBA in 88% of the patients at theoretically equivalent lower detection limits, suggesting that the detection limit of Quantiplex 2.0 may be higher than 500 HIV-1 RNA copies per ml. NASBA had the fewest invalid tests and good reproducibility, comparable to that of Quantiplex 2.0. The mean values from NASBA and Monitor were the most similar but the best correlation was observed between Monitor and Quantiplex 2.0 results. CONCLUSIONS: Monitor, NASBA and Quantiplex results were comparable, although those obtained by Quantiplex were significantly lower. Performing this study at comparable detection limits showed that the detection limit of Quantiplex 2.0 may be higher than stated by the manufacturer. PMID- 9949956 TI - Isoelectricfocusing and reverse blotting as a diagnostic tool in pediatric HIV infection. AB - BACKGROUND: Early diagnosis of perinatally acquired HIV-infection is based on either direct HIV detection--by means of viral culture and/or PCR--or anti-HIV antibody detection. However, due to the passive, transplacental passage of maternal immunoglobulin G, antibody detection is nor reliable until 15-18 months of age. In this regard, clonotypic analysis of specific antibodies performed by isoelectricfocusing and reverse blotting (IEF-RB) can be very helpful, as it recognizes possibly different patterns between mother and infant. OBJECTIVES: We used IEF-RB in order to analyze the kinetics of development of anti-HIV antibodies in infants born to seropositive mothers. STUDY DESIGN: Sera from ten mother/infant pairs (all mothers were HIV-infected) were retrospectively analyzed in order to detect different patterns, between mother and infant, in anti-gp120 V3-loop clonotype. RESULTS: We diagnosed the real HIV status of the examined infants no later than month 6 and in one case as early as month 2. CONCLUSIONS: Considering the small size of sample number, these data are preliminary and should be confirmed by larger scale studies. However, they show IEF-RB, when applied to infants born to seropositive mothers, may be useful in evaluating the infants' dynamics of anti-HIV humoral immune response. PMID- 9949957 TI - Microbiological aspects of clinical waste. AB - It is a requirement that hospitals and other areas that generate clinical waste must comply with good practice and legislation regarding its disposal. To meet the stringent European emission standards enforced in October 1995, there is a need to find an alternative to local incineration for dealing with clinical waste. The options included technologies such as gasification, steam sterilization or heat disinfection which can be used to process certain categories of clinical waste prior to landfill--all have advantages and disadvantages. Segregation of clinical and domestic wastes in healthcare settings is important to avoid accidents and litigation and to contain costs. Evidence that most clinical waste (other than perhaps waste from patients with certain infections and sharps) is a significant hazard to the public is lacking. More still needs to be done in the area of clinical waste management to assess the real risks and hazards of this waste. PMID- 9949958 TI - Is infection control an academic study? AB - This editorial aims to answer the question of whether infection control is an academic specialty. By considering the consequences of a lack of infection control in terms of patient morbidity and mortality and hence cost, it is easy to establish the importance of the area. Infection control embraces not only developing policies for preventing the physical spread of a micro-organism but also prophylactic therapy such as vaccination and therapeutic measures such as antibiotics. Infection control not only applies to localized infection in hospital due to antibiotic resistant microbes but also to the community. Bacteria such as Helicobacter pylori and Chlamydia pneumoniae and the viruses hepatitis B, hepatitis C, human lymphotropic virus type 1, Epstein-Barr viruses and human papilloma virus have been implicated in diseases not previously thought to have an infectious origin. Coping with these problems is clearly an academic area. PMID- 9949960 TI - An outbreak of Bacillus cereus respiratory tract infections on a neonatal unit due to contaminated ventilator circuits. AB - An outbreak of Bacillus cereus respiratory tract infections affecting six ventilated preterm neonates over a two-week period is described. Reusable ventilator circuits were identified as the cause of the outbreak. Ordinarily these were reprocessed on the Neonatal Unit (NNU), first through a washing machine and then through a low-temperature steam (LTS) disinfector. The onset of the outbreak coincided with a breakdown of the LTS facility, which necessitated sending the washed circuits off site for LTS disinfection. The washing machine was shown to be contaminated with the same serovars of B. cereus as those isolated from patients. Two critical steps in the off site LTS disinfection process allowed exsporulation and multiplication of B. cereus: the circuits were inadequately dried after processing, whilst return of the moist circuits to the NNU was often delayed. The outbreak was terminated by withdrawal of the heat disinfected ventilator circuits. This outbreak emphasizes the need for high standards where medical equipment is reprocessed, especially for use in vulnerable patients. PMID- 9949959 TI - Repeated multi-centre prevalence surveys of hospital-acquired infection in Greek hospitals. CICNet. Cretan Infection Control Network. AB - Three prevalence studies for the estimation of hospital-acquired infections (HAIs) were carried out in eight Greek hospitals on an annual basis during the years 1994-1996. The overall prevalence of HAI was 6.8, 5.5 and 5.9% for the three years, respectively. Among these, urinary tract infections ranged from 22.4 to 38.2%, lower respiratory tract infections ranged from 21.1 to 32.6%, surgical site infections ranged from 14.6 to 22.7% and bloodstream infections ranged from 9.0 to 13.2%. The prevalence of antibiotic usage among the hospitalized patients was found to be 49.3% in 1994, 47.3% in 1995 and 52.7% in 1996. Unjustified prescription of prophylactic usage was found to be the major component of these high percentages. Appropriate use of antibiotics for prophylaxis is one of the priorities of the current infection control programmes. The development of a nationwide network for the surveillance of HAIs in Greece is planned using the experience gained. PMID- 9949961 TI - Contaminated lithium heparin bottles as a source of pseudobacteraemia due to Pseudomonas fluorescens. AB - Pseudobacteraemia might be responsible for up to 50% of all positive blood cultures and its early recognition is important in order to avoid unnecessary treatment with antibiotics and delay in the search for the true cause of the fever. We describe pseudobacteraemia outbreak of Pseudomonas fluorescens related to contaminated lithium heparin bottles in a paediatric ward. Twelve patients were involved in this outbreak from December 1996-January 1997. All patients had no clinical evidence of sepsis, nevertheless most children were treated with antibiotics. Blood collection bottles were suspected as source of pseudobacteraemia and only lithium heparin bottles were found to be contaminated with P. fluorescences indistinguishable from the blood isolates taken from these children. Withdrawal of these bottles led to the termination of the pseudobacteraemia. Following discussion with the manufacturer, the contaminated batch of lithium heparin bottles was sent back for testing, and replaced with bottles containing dried lithium heparin. A hazard report was sent to the Medical Devices Agency (MDA). In order to minimize the possibility of this problem occurring again, the manufacturer has informed MDA that all lithium heparin solution is to be filtered to 0.2 micron prior to issue, in order to minimize bacterial contamination. Continued monitoring after the pseudobacteraemia showed no isolates of P. fluorescens from the blood of paediatric patients. PMID- 9949962 TI - Improved recognition of MRSA case clusters by the application of molecular subtyping using pulsed-field gel electrophoresis. AB - Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly common in hospital and community populations, making the recognition of true nosocomial outbreaks more difficult. We have used pulsed-field gel electrophoresis (PFGE) with Sma I digestion to analyse retrospectively two perceived outbreaks of epidemic methicillin-resistant Staphylococcus aureus 15 (EMRSA 15) colonization. The first cluster of cases in patients and staff on a general ward (ward D) revealed three different antibiograms based on differences in ciprofloxacin and rifampicin sensitivities. All isolates typed using PFGE, which was more discriminatory than phage-typing. One PFGE banding profile labelled type 5 was predominant, but 12 isolates proved to be subtypes of type 5 and two were PFGE type 11. Four staff members carried a strain not found in patients, three carried strains found in patients and transient carriage was highlighted as a problem when screening staff. PFGE enhanced the epidemiological data and proved that the cases on this ward did not comprise one large outbreak but numerous sporadic cases and smaller clusters. In contrast, isolates from a second cluster of cases which occurred on ward F were indistinguishable using antibiograms, phage-typing and PFGE, confirming this was more likely to be a true outbreak of colonization. We conclude that PFGE usefully augments epidemiological information and allows more logical infection control decisions to be made, with better utilization of scarce resources. PMID- 9949963 TI - An MRSA outbreak in a urology ward and its association with Nd:YAG coagulation laser treatment of the prostate. AB - An outbreak of methicillin resistant Staphylococcus aureus (MRSA) involving 88 patients in a general urology ward is described. Symptomatic bacteraemia and epididymo-orchitis occurred in 10 and 8% of patients respectively. Patients had a particularly high risk of acquiring serious MRSA infection after endoscopic neodymium yttrium aluminium garnet (Nd:YAG) laser treatment of the prostate. Appreciation of the mode of transmission of MRSA, a programme of continuing education for all medical and nursing staff, simple changes in ward protocol and advances in surgical laser technique contributed to the control of the outbreak. PMID- 9949964 TI - An in-vitro evaluation of the activity of chlorine against environmental and nosocomial isolates of Aeromonas hydrophila. AB - A chlorine preparation was tested against 34 strains of Aeromonas hydrophila isolated from a hospital water facility and patients with nosocomial infections in a French medical school hospital. In-vitro bactericidal activity was determined by a macro- and micromethod, using specific interfering substances over a range of dilutions and temperatures, after 1 and 5 minute exposure times. A 10(5)-fold reduction in the challenge inoculum was taken as the criterion of efficacy. Results obtained by both methods agreed and indicated a median minimal bacterial concentration of chlorine of from 0.95 ppm without interfering substances to 297 ppm in the presence of interfering substances. These data indicate that Aeromonas hydrophila isolates are relatively resistant to chlorine, thus precluding the use of chlorine alone as a disinfectant for water supplies contaminated with Aeromonas spp. PMID- 9949965 TI - Inactivation of feline calicivirus, a Norwalk virus surrogate. AB - Norwalk and Norwalk virus-like particles (NVLPs) [also known as small round structured viruses (SRSVs)] are members of the family Caliciviridae and are important causes of gastroenteritis in humans. Little is known about their survival in the environment or the disinfection procedures necessary to remove them from contaminated settings. As NVLPs cannot be grown in tissue culture, survival studies require the use of a closely related cultivable virus. This study assesses the survival of the surrogate feline calicivirus (FCV) after exposure to commercially available disinfectants and a range of environmental conditions. Disinfectants tested included glutaraldehyde, iodine, hypochlorite, a quaternary ammonium-based product, an anionic detergent and ethanol. Complete inactivation of FCV required exposure to 1000 ppm freshly reconstituted granular hypochlorite, or 5000 ppm pre-reconstituted hypochlorite solution. Glutaraldehyde and the iodine-based product effectively inactivated FCV whereas the quaternary ammonium product, detergent and ethanol failed to completely inactivate the virus. The stability of FCV in suspension and in a dried state was assessed after exposure to 4 degrees C, room temperature (20 degrees C) and 37 degrees C. With increasing temperature, the stability of FCV was found to diminish both in suspension and in the dried state. FCV in the dried state did not survive for one day at 37 degrees C. This study provides a basis for establishing guidelines for disinfection protocols to decrease the spread of NVLPs in a community setting. PMID- 9949966 TI - Evaluation of the antimicrobial activity of a new super-oxidized water, Sterilox, for the disinfection of endoscopes. AB - The antimicrobial activity of a new super-oxidized water, Sterilox, has been tested against Mycobacterium tuberculosis, Mycobacterium avium-intracellulare, Mycobacterium chelonae, Escherichia coli (including type O157), Enterococcus faecalis, Pseudomonas aeruginosa, Bacillus subtilis var niger spores, methicillin resistant Staphylococcus aureus, Candida albicans, poliovirus type 2 and human immunodeficiency virus HIV-1. Under clean conditions, freshly generated Sterilox was found to be highly active against all these micro-organisms giving a 5 log10 (99.999%) or greater reduction in two minutes or less. PMID- 9949968 TI - Revised guidelines for the control of methicillin-resistant Staphylococcus aureus infection in hospitals. PMID- 9949969 TI - Prevalence and antibiotic sensitivity pattern of methicillin-resistant Staphylococcus aureus in Ibadan, Nigeria. PMID- 9949970 TI - Decreased consumption of antimicrobial drugs after implementation of a new antibiotic policy in 1990. PMID- 9949967 TI - A hospital outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae. PMID- 9949971 TI - Weight loss is often a problem in late PD. PMID- 9949972 TI - External ventriculostomy devices EVDs. PMID- 9949973 TI - Building a support group for parents of children with brain tumors. AB - When parents are faced with the possibility of death or disability from their child's brain tumor, it manifests as a daily crisis. Some seek comfort and reassurance in sharing similar experiences within a support group. These groups have much to offer people who derive support from group interaction. Pediatric neuroscience nurses are in a unique position to coordinate and facilitate the development of a support group for parents of children with brain tumors. Although the literature identifies many reasons people join support groups, little has been explored among parents of children with a life-threatening illness. The literature stresses that the success of a group is in knowing why people attend groups and the ability to address the group's needs. PMID- 9949975 TI - Home care by and for relatives of MS patients. AB - Relatives and family members are the core of the care provided in the home. This also applies to relatives of multiple sclerosis (MS), patients who are dependent on assistance by others. If we want to keep the system of home care going, nurses must keep these care-providing relatives on their feet. We can only do this if we give timely support to these relatives in carrying out their care task and the problems that may arise from it. Once the relatives are overburdened, help is too late. Thus, prevention is an important task for home care nurses. It is crucial that the support the nurses offer fits the specific chemistry of MS patients and their relatives; their efforts will therefore be substantial. PMID- 9949974 TI - A case of rapid deterioration: acute multiple sclerosis of the Marburg type. AB - Multiple sclerosis (MS) is a chronic, progressive, degenerative, autoimmune disease that usually follows a relapsing-remitting course. In most cases of MS, the clinical course is variable with the vast majority of patients having mild to moderate disabilities that develop over the course of years. A subset of acute forms of MS exist and may be relatively unknown to neuroscience nurses. The acute forms follow a virulent course and are associated with high morbidity and mortality. A case presentation of a patient with the Marburg variant of MS raises the neuroscience nurse's understanding of the challenges associated with caring for patients with this unusual form of MS. PMID- 9949976 TI - Investigational neuroprotective drugs in traumatic brain injury. AB - Primary neuronal injury due to acute traumatic brain-injury may cause significant damage to the CNS. However, impaired cognitive and behavioral function also occurs following secondary neuronal injury. Neuroprotective agents should be administered soon after the acute event to prevent this secondary phase. NMDA receptor antagonists, free radical scavengers and bradykinin antagonists are designed to protect the neuron from the damaging effects of mediators. Calcium channel blocking agents and drugs promoting anaerobic glycolysis are designed to stop the intracellular processes causing ischemia. The standard treatment options for patients with brain injuries are limited. Thus, the possibility exists for poor outcomes. At this time, since there are no approved neuroprotective drugs available, experimental treatment offers a chance for improved outcomes. PMID- 9949977 TI - Getting the right tool for the job. AB - In summary, getting the right tool for the job requires several steps prior to using the tool in an anticipated study. Finding obtaining and evaluating the tool are all critical to a successful use of the tool in the study. If any of these factors are not followed, the researcher could be ethically or legally in trouble. Most tool developers want their tools to be used. It is up to the researchers to ensure that credit is given where credit is due, and that due process is followed. PMID- 9949978 TI - [Current role of x-ray technology in medical introscopy]. AB - The current role of X-ray equipment in medical introscopy is considered in the context of answers to the following questions: Why are there so many types of imaging? Does each unit of radiation diagnosis need they all? Which is the comparative clinical value of different methods of introscopy and what part is assigned to the routine X-ray equipment at present? Now the traditional X-ray equipment is shown to be transforming into the digital systems of X-ray imaging; however, progress in this branch is associated with the limited use of X-ray in some diagnostic fields. PMID- 9949979 TI - [Portable microfocal radiographic devices for medical diagnosis]. AB - The paper outlines two portable microfocal X-ray medical diagnostic devices which have a designing principle in common. The basic features of the devices are as follows: a thin long fight-path tube at whose end there is a massive or shooting target, a three-electrode electron gun, a private-line tungsten loop-shaped cathode, and a magnetic focusing system. PMID- 9949980 TI - [Surgical radiographic devices RTS-812 series]. AB - Surgical PTC-612 X-ray apparatuses are considered, their comparative characteristics and features are presented. PMID- 9949981 TI - [Intensifiers of radiographic image with digital output]. AB - The comparative parameters and characteristics of X-ray image intensifiers made by some Russian and foreign firms are given. It is noted that the 612 X-ray apparatus (Russia) are not inferior to its foreign analogues and they may be used for the equipping of rotating holding tables of all modifications, made both in Russia and foreign countries. PMID- 9949982 TI - [Renex-fluoro device for digital fluorography]. AB - The paper deals with the introduction of computer technologies into X-ray equipment. It gives data on various digital hardware components for digital fluorography, characterizes the digital fluorographs made in Russia. A new approach to designing a digital fluorograph is proposed by changing mechanical scanning via the use of a special fluorographic chamber having a supersensitive matrix photodetector. This approach has been applied in designing a Renex-fluoro apparatus. PMID- 9949983 TI - [X-ray image detectors in stomatology]. AB - The paper analyzes the technical level of the intraoral tooth films made in Russia and foreign countries, the potentialities of use of screen-amplifying film sets for periapical survey. PMID- 9949985 TI - [X-ray diagnostic complexes Medix-R and Telemedix-R with digital image recording]. AB - The paper outlines X-ray diagnostic sets made in Russia, whose modular principle allows one to choose the optimum price and quality delivery at different financing levels. The sets are equipped with up-to-date high-frequency X-ray image generators and intensifiers with a charge communication device-matrix as a television signal transducer. PMID- 9949984 TI - [Choice of the optimum intersection point for beam radiation axis in the planning of radiotherapy]. AB - A method has been developed to search for the optimum radiation regimen including the optimum radiation directions, the optimum duration of exposure, and the optimum point (center) of intersection of the central axes of radiation bundles. To solve the goal of determining the optimum radiation regimen for central lung cancer has indicated that variations in the intersection center of radiation bundles improves the radiation regimen. The optimum position of the intersection center of radiation bundles may greatly differ from the routine choice of the center. To standardize the optimum radiations in central lung cancer, it is necessary to solve special extreme tasks that minimize the numbers of the optimum radiation directions, which thus allows the main (structural) radiation directions to be identified. PMID- 9949986 TI - [Characteristics of dosimetric tests of x-ray diagnostic equipment]. AB - Some aspects of dosimetric tests in roentgenology are considered by taking into account the requirements developed by the IEC and ISO. PMID- 9949988 TI - [Substantiation of the choice of technical means in reduction of implementation costs of the project "Full automation of a central municipal hospital"]. AB - A way of reducing the cost price of hospital automation is proposed. It is not necessary for it to update the whole equipment, but only a small part--the workstations used by programmers for their work, which support the stability of hospital automation; the working places of operators should be kept without modifications, but to allot them properties to inherit a potency and modernity of the purchased equipment; for this purpose they should be equipped with virtual machines copying properties of workstations being arrange in accordance with the pyramidal structure. A UNIX which represents a multi-user, multitask operational operative system providing an access on several pseudoterminals is simultaneously installed on the PENTIUM 100/133 workstation. A graphic terminal of the AMR "UnTerminal" firm (USA) is proposed for use as working places. Their advantage is that they have a special adapter connected directly to the bus of PC extension. Each user is allotted a video adapter, a keyboard controller, sequential and parallel interfaces for connection of the printer and manipulator. Each working place supports multitasking and it can be equipped with a printer, a "mouse" or modem. The image is transmitted on work places with a very high velocity-77 mehabits/sec that supports not only a text mode, but also VGA or SVGA graphics. Certainly, graphic terminals are more expensive than text terminals, but their capacities are similar to those of the main computer, here, the workstation. They may be located from the main computer at a distance of up to 75 meters or more and do not require adjustment during their installation. PMID- 9949987 TI - [An orthogonal model of operative adjustment control of intraocular pressure parameters]. AB - This paper presents the algorithm developed by the authors for operative adjustment of parameters of an orthogonal model of intraocular pressure control. PMID- 9949990 TI - [Photo laboratory equipment for outfitting x-ray photo laboratory]. AB - The paper presents the equipment of the up-to-date photo laboratory set developed and delivered by the closed joint stock company "Roentgen-Komplekt" jointly with the closed joint stock company "Amico" (Russia). Devices for manual development of X-ray films, drying cabinets, negatoscopes, a lantern, developing frames, a laboratory assistant's X-ray table, etc. are described. PMID- 9949989 TI - [Detoxication and disinfection by sodium hypochlorite]. AB - Sodium hypochlorite electrochemically derived from aqueous sodium chloride solutions is the most convenient and physiological source of active oxygen. It is not toxic, easily excreted, has low molecular weight, small sizes, which allows it to readily penetrate through the cellular membranes and hence can oxidize toxins that are present not only in blood, but also in tissues, which is of great clinical practical value. The high reactivity and nonspecificity of sodium hypochlorite open ample scope for its wide medical applications. PMID- 9949991 TI - [Problems of technologic re-equipment of X-ray diagnostic services in the Russian Federation]. AB - The paper presents the data that characterize the engineering re-equipping of therapeutical- and-prophylactic institutions with various-purpose X-ray diagnostic apparatuses in the Russian Federation. It is concluded that there is a need for and a possibility of re-equipping Russia's X-ray diagnostic service by using latest home developments. It is shown that the diagnostic properties of equipment with the minimum expenditures can be enhanced provided that the main elements of the X-ray image formation pathway, which are enlisted in the paper, are primarily replaced. PMID- 9949992 TI - [Evaluation of the stability of parameters of direct radiographic devices]. PMID- 9949993 TI - [Clinical use of an instrument for measuring intraocular pressure]. PMID- 9949994 TI - [Biomaterials in an osteo-articular environment. Report of 129 anatomoclinical cases]. AB - Actually, there is a range of biomaterials which are synthetic or metallic (or the both). They are employed as prosthesis (biostability property) or as bone graft (bioresorbability property). To understand the interactions between cells and such materials, we studied with human bone cellular cultures the cytologycal, immunohistochemical, cytogenetical and ultrastructural aspects of biomaterials in cell cultures. This paper concerns bioceramics like Pyrost, coral, biosorb, oxbone and polymers like polyethylene and silicones. The aim of this work is to evaluate the efficiency of some biomaterials. We found that porosity is primordial to promote biodegradation of bone substitutes. In fact, the biomaterials is integrated and lead to an osteoconduction, an osteoformation and finally an osteoinduction. Our observations show the implant resorption and ossification occurring in the matrix which penetrate it. PMID- 9949996 TI - [THe Laumonier wax model of the ear (Collections of the Museums of the Anatomy Laboratory of Saints Peres, Paris)]. AB - Authentified by the name of Laumonier (fecit), written on the zygomatic process of the temporal bone, a model in wax of the medial, middle and lateral ears, belongs to the collection of the "Musees Delmas, Orfila et Rouviere" in Paris. This model presents large dimensions with a great anatomical rightness. The entire temporal bone is represented with the upper part of the endocranial petrous bone removed in order to demonstrate the main elements of the internal ear (cochlea and semi-circular canals) and of the middle ear (malleus and incus). Also were represented the temporal muscle and temporal vessels, the emergency of right cranial nerves, the superior orbital fissura and its elements; the internal carotid artery and the internal jugular vein, the upper part of the sterno-cleido mastoidal muscle and of the styloid muscles; the middle internal part of the basis of the cranium with the trunk of the trigeminal nerve, the Gasser's ganglion with its trifurcation, the sigmoid sinus. The dimensions are greater than the real size: total highness: 22 cm; total length: 46.5 cm; maximal highness of the ear cartilage: 16.5 cm; hemicranium width: about 22 cm. Thus the magnification of size is 2 or 3 if calculated on the basis of the external ear and 3 or 4 with reference to the half width of the cranium. The sample is fixed by two screws on a single wood board measuring 46.5 cm on 29.2 cm with two supplementary boards of 2.4 cm width under the two extreme of width, with a thickness of 1 cm. PMID- 9949995 TI - Comparison of the liver and biliary duct development in man and in the rat at the end of the embryonic period. AB - Hepatic and biliary structures present during embryonic Carnegie stage 23 were analyzed and compared in OFA-IOPS rat and human embryos. The group of embryos was composed of 3 rat specimens-crown rump length (CRL) 16 mm, age 16 days 5 hours post coltus- and of 1 human embryo- CRL 31 mm, age 57 days PC-. The specimens were submitted to serial histological sections with graphic reconstruction. In both species, the basic architecture of liver parenchyma was established including parenchymal cords or plates alternating with hepatic sinusoids. Veinous channels were clearly defined. The intrahepatic biliary system, referred as ductal plates (DP) developed into the periportal connective tissue while the portal spaces were not yet existing. DP was recognized either as a single layered cuboidal structure or as a double layered one dilated to form mature tubular ducts. The latter layout was more frequent in the rat. Except for gallbladder which is never present in the rat, similarity and presence of the same hepatic structure in both species at the end of the embryonic period (stage 23) suggest that the rat is a good experimental model for liver development and will be useful to understand the mechanism of congenital anomalies and specially the involvement of ductal plates in the congenital diseases of intrahepatic bile ducts. PMID- 9949997 TI - [The origins of embryology. Epistemologic and cultural viewpoints]. AB - Embryology is exemplar from an epistemologic point of view, due to its close relation with philosophy as studying an immediately accessible link in the process of generation. It has evolved to its present form following the development of the microscopical techniques at the end of the 18th century, but remains close to the ancient approaches of generation. The roots of modern Embryology are still to be found in the presocratic philosophers, and the works of Aristotle represent a major step in its foundation. Embryology also had a prominent place in the reappraisal of Aristotle's work by Albertus Magnus in the middle ages, following the islamic influences. This reappraisal opened the way to the scientific movement of the Renaissance, when Leonardo da Vinci played an essential role, approaching the development of the human embryo. Embryology is therefore linked to the major influence exerted by Aristotle on occidental civilization, it has then a prominent place from a cultural point of view. PMID- 9949998 TI - [Resistance of the the coraco-clavicular ligaments to traction: clinical application]. AB - One method for treating chronic incapacitating acromioclavicular dislocation is to resect the external extremity of the clavicle and to stabilise the stump by ligamentoplastic procedures, using the coracoclavicular ligament. The purpose of this work was to evaluate the mechanical quality of the ligamentoplastic approach. Twelve fresh cadavers, average age 80 years, were studied. The samples taken were 24 coracoclavicular ligaments, 24 coraco-acromial ligaments, 9 tendons from the palmaris longus muscle and 9 iliotibial tracts. The ligaments removed were tested in a Instron traction machine at a speed of 10 cm/mn. The mechanical properties of the coracoclavicular and coraco-acromial ligaments were studied. For comparison, those of the tendon of the palmaris longus muscle and the iliotibial tract were also studied. The results show the pre-rupture resistance of the coraco-acromial ligament to be 50% lower than that of the trapezoid and conoid parts of the coracoclavicular ligaments taken together. These results suggest the validity of ligamentoplastic treatment using the coraco-acromial ligament, but that reinforcement, using a tendon from the palmaris longus muscle or a piece of the iliotibial tract, may also be necessary, especially for subjects taking part in sports or with well-developed musculature. PMID- 9949999 TI - Annual update of how each state stands on legislative issues affecting advanced nursing practice. PMID- 9950000 TI - HEDIS for the primary care provider: getting an "A" on the managed care report card. AB - In 1999, quality in primary care will be measured more closely than ever before. Quality will not only be measured--but also reported-- and reported in a form that consumers can use to compare health plans. A health plan's accreditation will depend on its performance on a series of 14 performance measures, referred to as the Health Plan Employer Data and Information Set, Version 3.0 (HEDIS 3.0), which the National Committee for Quality Assurance, an organization that accredits health plans, has developed, quantified, refined, and publicized. This article introduces the primary care clinician to HEDIS quality measures and recommends tools clinicians can use to score well in performance evaluations. PMID- 9950001 TI - Effectively managing asthma in young and middle adulthood. AB - Revised national guidelines for managing asthma in nonpregnant young adults and adults stress education for self-management and include provisions for stepped care. These guidelines also include education on asthma pathophysiology; measures to control exacerbations; medications available to treat the disease; use of inhalers, spacers, holding chambers and self-monitoring; and peak expiratory flow meters. Treatment is based on frequency of exacerbations and readings from the peak flow meter. The stepped-care approach means aggressively treating patients at a higher step than current signs and symptoms may warrant, to gain rapid control over these signs and symptoms. The new guidelines suggest that patients with intermittent asthma use inhaled, short-acting bronchodilators, whereas those with persistent asthma should begin with daily inhaled, antiinflammatory medicines. Once control is maintained for weeks or months, dosages can gradually be reduced to the minimum effective level. PMID- 9950002 TI - Treating Alzheimer's disease with cholinergic drugs, Part 2. PMID- 9950003 TI - Overview of the 1996 Professional Liability Survey. PMID- 9950004 TI - The management of unexplained infertility. AB - Unexplained infertility is a diagnosis made by exclusion after all of the standard investigations have revealed no abnormality (1). The range of the prevalence is from 6 to 60 percent (23), depending on the diagnostic criteria. This article reviews the literature in the management of unexplained infertility; published data suggest no benefit of danazol or bromocriptine. The empirical use of clomiphene citrate suggests that ovarian stimulation using clomiphene citrate can double the spontaneous pregnancy rate (52, 58, 59). Induction of ovulation with human menopausal gonadotrophin (hMG) yields an overall pregnancy rate between 2 and 26 percent per cycle (68, 74). These results seem to be lower than those reported for in vitro fertilization (IVF) or gamete intrafallopian transfer (GIFT) procedures in similar patients (25-30 percent (92, 95)). Based on the literature, a rational treatment plan for treating infertility in couples with unexplained infertility includes up to four cycles of clomiphene citrate with or without intrauterine insemination (IUI). Superovulation with hMG and IUI or stimulated intrauterine insemination (SIUI) is the next step for three-cycle treatments and if unsuccessful, one of the variants of assisted reproductive techniques (ART) should be considered. TARGET AUDIENCE: Obstetricians & Gynecologists, Family Physicians. LEARNING OBJECTIVES: After completion of this article, the reader will understand the appropriate tests and work up for unexplained infertility, the various treatment options for the unexplained infertility couple including which drugs are effective and not effective, and to be able to outline an appropriate treatment plan for such patients. PMID- 9950005 TI - Lower genital tract intraepithelial neoplasia in HIV-infected women: guidelines for evaluation and management. AB - Human immunodeficiency virus (HIV) and human papillomavirus (HPV) are both sexually transmitted viruses with many risk factors in common. Studies have found that HIV-seropositive women are at least five times as likely to be infected with HPV as seronegative controls. In immunocompromised HIV-seropositive women, the risk of cervical intraepithelial neoplasia (CIN) is almost as high as in women with squamous intraepithelial lesions on their Pap smear. Some studies have shown the false-negative rate of cervical cytology in HIV-seropositive women to be very high, although others have shown it to be comparable with the rate in seronegative controls. However, given the prevalence of CIN in this population, even a "normal" false-negative rate may result in many missed CIN lesions. Among HIV-seropositive women and especially among those who are immunocompromised, CIN is more likely to progress and recur after treatment. Recurrence rates may reach 87 percent 36 months after treatment in markedly immunosuppressed women. Cryotherapy is especially ineffective in these patients. Vulvar condyloma and vulvar intraepithelial neoplasia (VIN) are much more prevalent in HIV seropositive women and especially in those who are markedly immunosuppressed or who have been immunosuppressed for a prolonged period of time. It is recommended that all HIV-seropositive women undergo periodic evaluation at intervals no less than every 6 months. Immunocompromised women should be followed with cytology and colposcopy of the cervix and vulva, although those with normal immune systems may be followed with cytology alone. Because the rates of recurrence and progression are so high after treatment of these women, they should be followed with colposcopy and cytology every 6 months. New approaches to treatment need to be explored in this population. TARGET AUDIENCE: Obstetricians & Gynecologists, Family Physicians. LEARNING OBJECTIVES: After completion of this article, the reader will understand the association between the immune suppression of HIV and HPV-related diseases, be familiar with the treatment options for the HIV seropositive woman with cervical intraepithelial neoplasia (CIN), understand the natural history of CIN in the patient with HIV-seropositivity, and become aware of the appropriate surveillance of the HIV-seropositive woman treated for CIN. PMID- 9950006 TI - Vasa previa: an avoidable obstetric tragedy. AB - Vasa previa is a rarely reported condition in which the fetal blood vessels, unsupported by either the umbilical cord or placental tissue, traverse the fetal membranes of the lower segment of the uterus below the presenting part. The condition has a high fetal mortality due to fetal exsanguination resulting from fetal vessels tearing when the membranes rupture. Despite improvements in medical technology, vasa previa often remains unsuspected until this fatal fetal vessel rupture occurs. Significant reduction in the fetal mortality from this condition depends on a high index of suspicion leading to antenatal diagnosis, and elective delivery by cesarean. We believe transvaginal ultrasound in combination with color Doppler is the most effective tool in the antenatal diagnosis of vasa previa and should be utilized in patients at risk, specifically those with bilobed, succenturiate-lobed, and low-lying placentas, pregnancies resulting from in vitro fertilization, and multiple pregnancy. Where there has been antepartum or intrapartum hemorrhage, especially when associated with fetal heart irregularities, we also recommend a test to exclude fetal blood in the vaginal blood. Similarly, amnioscopy before amniotomy may help to diagnose this condition. Cesarean delivery is the method of delivery of choice, and aggressive resuscitation of the affected neonate may be life saving. With a high index of suspicion, antenatal diagnosis using transvaginal sonography in combination with color Doppler, elective delivery by cesarean, and aggressive resuscitation of the neonate where fetal vessel rupture has occurred, the mortality from this complication may be considerably reduced. TARGET AUDIENCE: Obstetricians & Gynecologists, Family Physicians. LEARNING OBJECTIVES: After completion of this article, the reader will be able to identify the risk factors and associated conditions for vasa previa, to identify the various clinical presentations and management of vasa previa, and to be aware of the diagnostic tools available to make the antepartum diagnosis of vasa previa. PMID- 9950007 TI - Ambiguities in office-related injury: the poverty of present approaches. AB - This is a straightforward entry into the fray over the association of upper extremity disorders with the modern workplace. The authors point out that successful intervention and prevention efforts are underway around the world, despite the continuing debate on theory. PMID- 9950008 TI - Risk factors for musculoskeletal disorders among computer users. AB - This investigation of current epidemiologic and ergonomic research demonstrates consistent relationships between certain computer-related factors and musculoskeletal disorders. PMID- 9950009 TI - Multiple nerve entrapment syndromes in office workers. AB - Reports of nerve compression syndromes have been increasing in frequency. The authors discuss evaluation, management, and surgical repair of these multifactorial disorders. PMID- 9950010 TI - The changing nature of office work: effects on repetitive strain injuries. AB - This historical perspective underscores that there is rarely a simple connection between the demands of a particular technology and the risk of occupational disease. PMID- 9950011 TI - Surveillance and the problems of assessing office-related injury. AB - Early reporting of work-related musculoskeletal disorders (WMDs) may be the key to a successful prevention program. Dr. Morse discusses active versus passive surveillance, models for estimating costs of WMDs, and psychosocial issues. PMID- 9950012 TI - RSI: a perspective from its birthplace. AB - The Australian experience is a tale of two RSIs--an endemic condition and an epidemic condition. PMID- 9950013 TI - Office technology and musculoskeletal disorders: building an ecological model. AB - Symptoms drive health care utilization. Therefore, health care costs are reduced by reducing musculoskeletal injuries through job redesign, ergonomics, or changes in work scheduling. PMID- 9950014 TI - Musculoskeletal disorders in visual display unit work: gender and work demands. AB - In addition to physiologic differences between men and women, differences in pain reporting and medical care-seeking behavior, job assignments and ergonomic exposures (including work in the home), and strategies for performing various physical tasks must be considered. PMID- 9950015 TI - A low-cost, effective approach to office ergonomics. AB - Much discomfort can be eliminated simply by adjusting lighting and work station components. PMID- 9950016 TI - Psychosocial elements in the work environment of a large call center operation. AB - The author investigates psychosocial factors that prevent early detection of injuries and the effect of late reporting on the long-term health of workers. PMID- 9950017 TI - Economic losses from repetitive strain injuries. AB - Lost employment income and inability to perform household activities can have a devastating impact on the individual suffering from repetitive strain injury. PMID- 9950018 TI - Training and retraining of office workers and musicians. AB - Both ergonomic and biomechanical principles must be applied to avoid and correct overuse syndromes. Equipment should be fitted to the user, but the user's interaction with the equipment should be examined, as well. PMID- 9950020 TI - Advanced systolic heart failure: emerging pathophysiology and current management. AB - Systolic heart failure leads to progressive left ventricular impairment, has a poor prognosis and negatively affects the patient's quality of life, especially when the disease advances to the point where it causes refractory symptoms. Ventricular remodeling, one of the consequences of advanced systolic heart failure, results from complex pathophysiologic mechanisms and leads to hemodynamic compromise, clinical deterioration and death. The nursing literature on heart failure has focused on neuroendocrine changes and the pharmacologic management in response to these changes. Little emphasis has been placed on other pathophysiologic mechanisms that lead to a worsening of ventricular function or on advances in clinical research that may influence current and future nursing management of the patient throughout the continuum of care. For therapy to be individualized, it is necessary for nurses to understand the pathophysiology of systolic heart failure and the importance that nursing actions have on augmenting medical management to alleviate symptoms and to deter the progression of the pathophysiologic state. Such an understanding should ultimately reduce morbidity and mortality and optimize quality of life. PMID- 9950019 TI - Effect of dressings on saphenous vein harvest incision pain, distress and cosmetic result. AB - Little research has examined the healing and pain associated with saphenous vein (SV) harvest incisions, and no literature has addressed the associated distress and cosmetic result. The purpose of this study was to determine whether dry sterile gauze dressings, transparent film dressings or no dressings were more effective in hospitalized patients undergoing coronary artery bypass graft (CABG), in terms of minimizing leg incisional pain, minimizing the distress of a leg scar and improving the cosmetic appearance of the leg incision scar. Patients were randomized to dressing type on postoperative day (POD) 1, completed a pain and distress visual analogue scale (VAS) on PODs 1, 3 and 5, and a cosmetic result VAS upon discharge. Overall, leg incisional pain decreased over time (p < 0.05). Females reported decreasing pain between PODs 1 and 3, while males reported increasing pain between PODs 1 and 3 (p < 0.05). The film-dressing group reported decreasing pain from PODs 1 to 3, while the no-dressing and gauze dressing groups reported increasing pain from PODs 1 to 3 (p < 0.05). Pain on POD 5 was positively correlated with an unfavorable cosmetic result (r = 0.42, p < 0.05), and distress on POD 5 was positively correlated with an unfavorable cosmetic result (r = 0.44, p < 0.05). The results of this study are encouraging and support the continued testing of dressings to minimize pain and distress, as well as enhancing cosmetic result. PMID- 9950021 TI - Fast tracking in cardiac surgery: implications for practice. AB - Even though economic incentives might have been the impetus for its revival, fast tracking offers numerous other benefits, not the least of which is improved patient care. However, its benefits can be realized only through specific perioperative management, including preoperative assessment, identification and selection of appropriate candidates, optimal intra- and postoperative management and interdisciplinary discharge planning. Through interdisciplinary collaboration, the maximum benefits of fast tracking can be reaped by both the patient and the healthcare team. PMID- 9950022 TI - Use of epoprostenol (Flolan) in the management of primary pulmonary hypertension. PMID- 9950023 TI - Secondary prevention and treatment of hypercholesterolemia in women. PMID- 9950024 TI - Help, I am being sued!! PMID- 9950025 TI - Differential diagnosis of wide QRS complex tachycardia. PMID- 9950026 TI - A personal account of events leading to the definition of the apoptosis concept. PMID- 9950027 TI - Molecular mechanisms of apoptosis: an overview. PMID- 9950028 TI - The death receptors. PMID- 9950030 TI - Lymphocyte-mediated cytolysis: dual apoptotic mechanisms with overlapping cytoplasmic and nuclear signalling pathways. PMID- 9950029 TI - Lipid and glycolipid mediators in CD95-induced apoptotic signaling. PMID- 9950031 TI - Granule-mediated cytotoxicity. PMID- 9950032 TI - The cell cycle and apoptosis. PMID- 9950033 TI - The p53 tumor suppressor gene: structure, function and mechanism of action. PMID- 9950034 TI - The Bcl-2 protein family. PMID- 9950035 TI - Apoptosis and the proteasome. AB - The ubiquitin-proteasome pathway is responsible for the regular turnover of a wide variety of proteins and is a critical regulator of many cellular processes. Although this pathway is abundant and ubiquitous, it is also discriminating. This specificity is achieved because there are multiple levels of regulation at work in the pathway. X-ray crystallographic data on the eukaryotic 20S proteasome suggest that substantial rearrangement of the alpha rings, probably mediated by the association of additional regulatory complexes, is required to allow access of substrates into the inner core of the complex. The associated complexes also confer a ubiquitin-dependence on the proteasome, requiring that potential substrates be tagged with chains of ubiquitin proteins. The presence of multiple ubiquitinating enzymes that favor distinct substrates provides a way for a cell to regulate what proteins are to be ubiquitinated. In some cases ubiquitination is not required, but we now know that other modifications, such as phosphorylation and protein-protein interactions, are also important for targeting proteins for degradation. Even with the existence of so many regulatory controls, it is difficult to imagine how one complex can perform so many tasks. As more information is gathered about the proteasome, we begin to understand that all proteasomes are not exactly the same. For example, there is strong evidence that proteasomes involved in antigen presentation differ in both composition and function from proteasomes involved in other processes. The past image of the proteasome as a static structure is being shed, and a new image is emerging that portrays the complex as dynamic and flexible, able to tailor its composition and function to meet a particular need. With this new image of the proteasome in mind, investigators are looking at the potential involvement of the proteasome in cell death. Inhibitor studies have demonstrated a requirement for proteasomes during apoptosis in noncycling and differentiated cells. Similar studies in cycling cells suggest that the proteasome may regulate a cell's decision to proliferate, differentiate, or die. It will be necessary in the future to supplement the peptide and lactacystin studies with work that is not inhibitor driven since the specificity of an inhibitor for a particular protease is always in question. In addition, a real understanding of how proteasomes may regulate this process awaits the identification of its substrates. With cell death investigators showing increased interest in proteasomes, it may be possible in the next few years to determine the precise role of the proteasome in the pathways that lead to the death of a cell. PMID- 9950036 TI - [Rapid diagnosis and susceptibility of Mycobacterium tuberculosis to antibiotics using MGIT system]. AB - New technologies for rapid detection and drug susceptibility testing of mycobacteria are needed in clinical laboratories in order to attempt a rapid diagnosis and effective treatment of tuberculosis (TB) specially of cases resistant to isoniazid (H) and rifampin (RMP) (MDR-TB). A total of 218 pulmonary specimens from 132 HIV coinfected patients were processed and inoculated into the Mycobacterial Growth Indicator Tube system (MGIT, Becton Dickinson, MD) and on Lowenstein-Jensen (L-J) and Stonebrink (SB) solid media. The average time for recovering Mycobacterium tuberculosis (MTB) from MGIT was 18.3 days and 31.0 days from solid media. Of the patients 14.4% (19/132) were only diagnosed by MGIT. In another experiment susceptibility tests by the classical proportion method (PM) in L-J medium with H, RMP, streptomycin (SM), para-aminosalycilic-acid and ethambutol (EMB) were carried out on 120 isolates. The results were later compared with those obtained by determining the minimal inhibitory concentration (MIC) for each drug in MGIT against the above mentioned isolates. MIC results from MGIT method were available in an average of 5 days (3-10) and they correlated (correlation index 0.9974) with those of drug susceptibility obtained by the PM. A 4.7% (2/42) of disagreement among detecting isolates resistant to H and SM was found between PM and MGIT. Our results showed MGIT as a useful, safe and timesaving culture system, specially for detecting TB resistance. It might be used in clinical laboratories to improve the proper management of TB patients. PMID- 9950037 TI - Effect of fortification of concentrated whey on growth of Kluyveromyces sp. AB - The effect of fortification of concentrated whey with 0.5% inorganic nitrogen viz. NH4Cl, (NH4)2SO4, NaNO3 and urea, organic nitrogen viz. tryptone, tryptose, peptone and yeast extract and 0.1% metal ions viz. K2HPO4, MgSO4 and FeSO4, on growth stimulation of Kluyveromyces marxianus subsp. marxianus NRRL Y-665, NRRL Y 1195, NRRL Y-2415 and Kluyveromyces marxianus subsp. lactis NRRL Y-1193 were studied. Supplementation with 0.5% (NH4)2SO4, peptone, yeast extract or 0.1% K2HPO4 individually increased the biomass production by 8-20%, 17-25%, 13-14% and 14-17%, respectively. Addition of 0.5% each of (NH4)2SO4, peptone, yeast extract and 0.1% K2HPO4 together is recommended to increase the biomass production by 81 98% for commercial production of single cell protein. PMID- 9950038 TI - [Prevalence of Flavivirus antibodies in young voluntary recruits to military service in the province of Formosa, Argentina]. AB - The aim of the present study was to investigate the seroprevalence to Flavivirus, in young people living in risk areas. We analyzed 189 human sera from 3 towns in the Province of Formosa. This area corresponds to the border that limits Brasil and Paraguay and the aim was to search for a possible introduction of Dengue and Yellow Fever from these countries. Serological tests such as haemagglutination inhibition (HI), complement fixation (CF) and neutralization (NT) were performed using St. Louis encephalitis (SLE), Bussuquara, Ilheus, Yellow fever and dengue 1 and 2 viruses. No definite evidence for HI antibodies to dengue and Ilheus was obtained. One serum cross-reacted only with yellow fever and two sera only for Bussuquara by the HI test. Only one serum was confirmed to be positive for Bussuquara by NT test. A total of 22 sera from 189 were positive for SLE by the HI test and 40 were also reactive by the NT test. The seroprevalence measured by HI and NT antibodies was similar in the three departments studied. These results show that SLE virus is present in the North of Argentina with an important value of prevalence so that this agent could play an important role in the febrile infections not virologically confirmed. PMID- 9950039 TI - [Mucormycosis: Study of five cases found in San Juan de Dios hospital and Sor Maria Ludovica hospital in La Plata, Argentina]. AB - Hospital San Juan de Dios and Sor Maria Ludovica in La Plata, between 1980 and 1997. Mucormicosis is a frequently fatal, opportunistic fungal infection, that affects immunocompromised patients. The risk factors include diabetes mellitus, leukemia, lymphoma, burns, etc. We present three cases of cutaneous mucormicosis in children 3, 10 and 11 years old, who had been sent to the hospital due to compound fractures in a car crash; one case of pulmonary mucormicosis in an adult 28 years old with prolonged corticotherapy and rhinocerebral mucormicosis in a patient 38 years old with a diagnosis of acute lymphoid leukemia. PMID- 9950040 TI - [Salmonella: comparison of methods for its detection in bird feed]. AB - The Gene Trak colorimetric hybridization method (GENE TRAK Systems, 31 New York Avenue, Framingham, M.A.) was compared with conventional methodology proposed by International Commission for Microbiological Standard Foods (ICMSF) for the detection of Salmonella in samples of broiler feed and raw materials of vegetal and animal origin used in its formulation. In this study 249 samples which included inoculated samples and 9 uninoculated samples were studied. On 240 uninoculated samples, 62.9% resulted free of Salmonella, 27.9% were positive for both methods and 9.2% were positive by Gene Trak but it couldn't be confirmed by conventional methodology after five determinations. This methodology is presented as an interesting method of screening with important advantages in comparison to conventional methodology: facility for processing a big number of samples with few material expenses, less time to get results and high sensibility. PMID- 9950041 TI - [Effect of cyclophosphamide in experimental histoplasmosis in the rat]. AB - Histoplasmosis is a fungal disease caused by the dimorphous fungus Histoplasma capsulatum (Hc). Cyclophosphamide (Cy) was used as an immunomodulator capable of modifying the course of the disease, as well as of regulating the mechanisms involved in T-lymphocyte mediated immune response. Rats were subjected to intracardiac inoculation of Hc followed by a fractionated treatment with a 100 mg/kg body weight dose of Cy on days +4, +5, +6, +7 and +11 pi. Until day 26 pi, treatment with Cy caused 85% mortality whereas no mortality was observed among animals only inoculated with Hc. On day 14 pi, the group of Hc animals showed a delayed hypersensitivity test (DH) of 26.60 + 13.96 as determined by the swelling of the leg. Conversely, DH was significantly depressed in rats inoculated with Hc and treated with Cy: 3.88 +/- 1.00 (p < 0.01). Colony forming units count in this group was 2020 CFU/g of spleen, and 24 CFU/g of spleen (p < 0.01) in controls. A macroscopic study of the organs revealed that the animals in the Hc+Cy group had spleenomegaly and lungs with granuloma and hemorrhagic spots. The controls only presented small lung abscesses. These findings lead to the conclusion that Cy causes a deterioration of cell mediated immune response which results in the manifestation of an acute, fatal experimental mycosis. PMID- 9950042 TI - Characterization of hepatitis C virus genotypes in an hemodialysis unit in Paysandu, Uruguay. AB - Hepatitis C virus types were investigated by using samples from eight sero reactive and PCR positive patients attending our Hemodialysis Unit en Paysandu, Uruguay. After HCV RNA detection by reverse transcription and polymerase chain reaction, HCV genotyping was carried out by a nested PCR amplification, using type specific primers of HCV core region. These results were confirmed using a method based upon reverse hybridation of amplified products by enzyme-labeled type-specific probes to portions of the 5' UTR region. HCV genotypes were assigned according to Simmonds' classification. Type 1b was found in five patients, type 3a was found in one and one patient was not classified. There was a patient who became PCR negative at the moment the genotyping was carried out. PMID- 9950044 TI - Epidemiology and the European Commission. PMID- 9950043 TI - [Growth in species of the genus Ascobolus (Pezizales-Ascomycetes)]. AB - The kinetics of growth of eight heterothallic species of the genus Ascobolus was studied in liquid culture media. The results obtained showed variation among the species in the duration of the different phases of the growth cycle. Three groups can be recognized considering the extension of the exponential phase of growth. The stationary phase, which differs in its length, is frequently very short, entering quickly in the phase of death, accompanied by autolysis of the mycelium. PMID- 9950045 TI - Improvement of the quality and comparability of causes-of-death statistics inside the European Community. EUROSTAT Task Force on "causes of death statistics". AB - BACKGROUND: Cause-of-death statistics are widely used for comparing health characteristics of European Community (EC) countries. Before attempting to interpret between-country differences, it is essential to assess the biases affecting the comparability of the data. EUROSTAT decided to address globally this problem with the objective to improve the quality and comparability of cause of-death data within the EC. METHODS: The material is based on a review of results of international comparative cause-of-death studies and on specific inquiries among EC. Both cause-of-death certification and codification practices are analysed. Certification is studied comparing the models of death certificates, the type of information captured, certifiers training and querying practices. The different coding systems are analysed (International classification of diseases (ICD) in use, interpretation of the ICD rules, implementation of automated coding systems). RESULTS: International studies on comparability of certification and coding practices between countries are rare. These studies are based on certification of cases histories and recoding of samples of death certificates. Recent studies on respiratory diseases, cancers and diabetes outline differences that influenced on the reported level of mortality. The specific EUROSTAT investigation (1997) outline general discrepancies: models of death certificates, nature and amount of information entered, way to establish the diagnosis, degree of consistency of the certification process, autopsy practices, certifiers practices, implementation of ICD-10 and implementation of automated coding systems. CONCLUSION: EUROSTAT studies are now focused on causes of death requiring special attention for comparability (e.g. suicide, accidental deaths, drug and alcohol related deaths, unknown and ill-defined causes), on procedures to improve the homogeneity of certifiers training and querying practices, on the effect of the transition to ICD-10. The international model of death certificate recommended by the World Health Organization should be adopted as widely as possible. Uniform complementary information (e.g. surgery, pregnancy, autopsy, place of occurrence of accidental deaths, work accident) should also be adopted. The EUROSTAT investigations must result in definitions of common recommendations and guidelines to EC. PMID- 9950046 TI - [European surveillance of infectious diseases: the case of AIDS and tuberculosis]. AB - In 1992, the Maastricht treaty gave specific responsibilities to the European Community in the field of research, information and health education. Several European surveillance systems for infectious diseases have been organised. The surveillance of AIDS was set up in 1984 after the emergence of this new disease. Seven western European countries participated initially. The system currently covers 48 of the 51 countries of the WHO European region. Based on a common case definition, it enables analysis of trends and comparisons which considerably facilitate the understanding of the epidemic and its determinants, and the evaluation of preventive actions. European countries have now decided to set up a reporting system for HIV infection. The surveillance of tuberculosis started in 1996 in response to the reversal of trends in reported cases observed in western Europe and to the threat of multi-drug resistant tuberculosis epidemics. Common recommendations on definitions and data collection procedures facilitated its establishment. Most countries of the WHO European region participated in the first year, revealing a very heterogeneous epidemiological situation. The next objective is to set up a surveillance system for antituberculosis drug resistance. The European surveillance of AIDS and tuberculosis are examples of systems adapted to the specific characteristics of Europe: similarities in diagnostic procedures, similarities in access to treatments, and common requirements regarding both the exchange of information and the coordinated response to public health threats. They are not simply looking for a common denominator. They are creating a real momentum among participating countries towards a better quality and a higher level of pertinence of the information. PMID- 9950047 TI - Socio-economic inequalities in mortality. Methodological problems illustrated with three examples from Europe. AB - BACKGROUND: Studies from most European countries have been able to demonstrate that lower socioeconomic groups have higher risks of disease, disability and premature death. Uncertain is, however, whether these studies have also been able to estimate the precise magnitude of these inequalities, their patterns and their trends over time. The purpose of this paper is to illustrate the extent to which results of descriptive studies can be biased due to problems with the data that are commonly available to European countries. METHODS: Three illustrations are presented from a project on socio-economic inequalities in premature morbidity and mortality in Europe. These illustrations concern three problems often encountered in data on social class differences in mortality among middle aged men: the numerator/denominator bias in cross-sectional studies (illustrated for France), the exclusion of economically inactive men (illustrated for 4 countries), and the use of approximate social class schemes (illustrated for Sweden). RESULTS: In each illustration, inequalities in mortality among middle aged men could be demonstrated, but data problems appeared to bias estimates of the precise magnitude of inequalities in mortality, their patterns by social class and cause of death, and their trends over time. The bias was substantial in most cases. Usually, it was difficult to predict in which ways and to what extent inequality estimates would have been biased. CONCLUSIONS: When the aim of a study is to determine the precise magnitude, patterns or time trends of health inequalities, the results should be evaluated carefully against a number of potential data problems. Investments are needed, e.g. in data sources and in the measurement of socio-economic status, to secure that future studies can describe socio-economic inequalities in health in Europe in more detail and with more reliability. PMID- 9950048 TI - Health observation and health reporting in Europe. AB - The need and demand for comparable comprehensive health data and health information is growing in Europe. Many countries have intensified development of their health information systems and health reporting. The World Health Organization (WHO), the Organization for Economic Cooperation and Development (OECD) and other international organizations collect health data and publish comparative health reports. The European Union (EU) has initiated several new activities to improve health statistics and to develop health monitoring. Sometimes they overlap with other international activities. Also, EU Agencies have been set up in several health related fields. EU public health programmes on specified health problems also monitor health. The Health Monitoring Programme (HMP) adopted in 1997 is intended to pave the way for permanent EU health monitoring. After an unfortunate delay, the first HMP decisions to fund projects were made in July 1998. A feasibility analysis resulting in proposals for the organization of EU health monitoring was carried out in 1997. Other recent developments in the EU are the establishment of a communicable disease network, and the Commission's communication on future public health policy. The Amsterdam Treaty attaches more importance to public health. Much work needs to be done before a coherent EU health monitoring system can be put in place. The current momentum must be used to speed up positive developments. The HMP should support projects which pave the way for permanent EU health monitoring and its work should be clearly prioritised. Also, the expertise in health monitoring and the ability to steer the HMP and related EU developments should be strengthened. This can best be done by close collaboration with experienced expert institutes from the Member States, and by collaboration with WHO and OECD. PMID- 9950049 TI - Ten years of research on asthma in Europe. The European Community Respiratory Health Survey. AB - The European Community Respiratory Health Survey was designed to provide basic information on the prevalence and distribution of asthma in Europe, to asses whether any variation noted could be explained by the distribution of atopy and other risk factors, and to determine the distribution of therapy for asthma. The project has developed a methodology for studying these factors in different settings and has provided a mechanism for quality control in the collection and analysis of the data. Initially funded to look within the European Community, it has been expanded to include selected areas outside Europe. The descriptive analyses are now almost complete, but there is still a great deal of further analysis to be undertaken on the relation between risk factors and atopy and asthma within the data set. PMID- 9950050 TI - [Management of risk factors after coronary heart disease in European countries]. AB - BACKGROUND: Despite clinical and epidemiological evidence of benefits from sustained management of vascular risk factors following coronary heart disease, the implication of physicians in secondary prevention remains limited. In 1994, several European scientific societies published jointly guidelines for the prevention of coronary heart disease in clinical practice, ranking as the highest priority the reduction of risk factors in coronary patients. METHODS: The European Society of Cardiology launched at the same period a study on the prevalence and management of vascular risk factors of coronary patients in Europe, the EUROASPIRE project. Six months after a coronary event 3,569 patients, from a total population of 4,863 affected individuals recruited in hospitals of 9 European countries, were interviewed and examined to estimate the levels and management of their vascular risk factors. RESULTS: At least six months after discharge, one patient out of five kept on smoking, one out of four was still obese, one out of two had high blood pressure levels and 44% total cholesterolemia over 5.5 mmol/L. More than 8 smoking patients out of 10 attempted to stop smoking and 8 obese patients out of 10 attempted to lose weight. More than 40% of patients, treated or not for hypertension, had systolic blood pressure levels over 140 mm Hg, and almost one patient out of two, treated or not treated for dyslipemia, a total cholesterolemia over 5.5 mmol/L. CONCLUSIONS: Given the high prevalence of vascular risk factors in coronary patients, efficient secondary prevention aiming at the reduction of the levels of these risk factors, may have a major impact on the decrease of morbidity and mortality of these patients. Thus, joined European efforts to elaborate, diffuse and evaluate secondary prevention strategies towards physicians and patients should be rapidly developed to facilitate the achievement of such benefits for coronary patient health. PMID- 9950051 TI - [Epidemiologic research and road traffic accidentology in Europe]. AB - Every year there are 1.7 million road casualties on EU roads, of which 46,000 are fatal. With reference to the three main sources of information available (the police, the medical profession, and insurance companies), we have extracted epidemiological results for this important public health issue, taking into account the relevance of this approach in terms of its exhaustiveness and representativity. Finally, referring to different ad hoc etiological and evaluative research, we have put forward some ideas on the possible contribution that epidemiology could make to a better understanding of road traffic accidents. Given that current research is coordinated at an EU level, we have confined our analysis to the 15 member countries of the EU. PMID- 9950053 TI - [European Program for Intervention Epidemiology Training (EPIET): a training epidemiologic intervention in Europe]. AB - The European programme for interventional epidemiology training (EPIET) offers a two year practical training in European national institutes mandated for the surveillance and control of communicable diseases. The training, closely supervised by senior epidemiologists, allows each EPIET fellow to learn while serving and conducting tasks devoted to intervention epidemiologists (surveillance, investigation, research, aid to decision making, and communication with the public, the media, the health authorities and the scientific community). The programme is equally funded by the European Commission, the 15 member states, Norway and the World Health Organisation. This training, derived from the North American and British experiences offers a practical complement to knowledge acquired from European universities. EPIET fellows, their supervisors and colleagues from training institutes have rapidly formed a network of intervention epidemiologists necessary for conducting and coordinating the surveillance of communicable diseases in Europe. PMID- 9950052 TI - [Evaluation and comparison of tobacco control legislation in member states of the European Union]. AB - BACKGROUND: Nowadays, tobacco use represents the main cause of avoidable deaths in Europe. Public health authorities have several means at their disposal to fight against this epidemic. For instance, legislative action can operate on the supply side as well as on the demand side, with the aim of reducing tobacco consumption in the targetted populations. METHODS: A systematic data collection of all legislative texts dealing with tobacco control was carried out within the framework of the EuroLego project. This was done, either through direct contact with the countries or through a systematic computer and manual search of data bases concerning the 15 member states of the European Union. RESULTS: At present, the legislative context varies widely from one country to another, whether regarding the number of texts adopted or the subject that is covered. Since the 1950s, a marked increase in the number of legislative texts has been noted as well as a trend towards harmonization of the texts among the different member states. CONCLUSIONS: Several health recommendations can be put forward in the context of public health activities with priority to be given to the protection of the children and the young and to the defense of the rights of non-smokers. PMID- 9950054 TI - [The risk in epidemiology and in public health: risk management. 1988]. PMID- 9950055 TI - [Long term intellectual and behavioral outcomes of children with febrile convulsions]. PMID- 9950056 TI - A di-synaptic projection from the superior colliculus to the head of the caudate nucleus via the centromedian-parafascicular complex in the cat: an anterograde and retrograde labeling study. AB - Centromedian-parafascicular (CM-Pf) complex of the thalamus receives inputs from the superior colliculus (SC). The CM-Pf neurons, in turn, project to the neostriatum. In order to establish a circuitry that the efferent terminals of SC neurons make direct synaptic contacts with thalamostriatal neurons in the CM-Pf complex, the anterograde tracer (biocytin) was injected into the unilateral SC and the retrograde tracer (wheat germ agglutinin conjugated to horseradish peroxidase, WGA-HRP) into the ipsilateral head of the caudate nucleus of the cat. The anterogradely labeled SC fibers and their terminals and retrogradely labeled CM-Pf neuronal elements were examined under light and electron microscope. At the light microscopic level, biocytin-labeled terminal-like varicosities were observed densely in the latero-dorsal part of the CM and the dorsal part of the Pf lateral to the fasciculus retroflexus. These varicosities were often in close proximity to HRP-labeled somata and dendrites of CM-Pf neurons. Electron microscopic analysis revealed that the biocytin-labeled synaptic boutons contained mainly round synaptic vesicles and established asymmetrical synaptic contacts with retrogradely labeled thalamostriatal neuronal elements, including perikarya, and small and large dendrites. In addition, anterogradely labeled terminals made synaptic contacts with unlabeled somata, small and large dendrites, and spines as well as profiles containing synaptic vesicles. These vesicle-containing profiles were considered to be pre-synaptic elements contacting on thalamostriatal neurons or the vesicle-containing dendrites of local circuit neurons. These results demonstrate that the neurons of the CM-Pf complex of the thalamus is involved in a di-synaptic tecto-striatal circuit. PMID- 9950058 TI - Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module. AB - Neuroglycan C (NGC) is a 150 kDa transmembrane chondroitin sulfate proteoglycan with a 120 kDa core glycoprotein that was originally isolated from the developing rat brain. A rabbit antiserum, raised against a recombinant polypeptide representing a protein of the rat NGC core protein, recognized an NGC homolog in homogenates of brains of various vertebrates including humans. Because of the possible involvement of this proteoglycan in the etiology of a human neuronal disease, we cloned a complete coding sequence from a human brain cDNA library using a rat NGC cDNA as a probe. The predicted protein contains 539 amino acids and shows 86% homology with the rat counterpart. The domain structure characteristic of rat NGC was completely conserved in human NGC, which consisted of an N-terminal signal sequence, a chondroitin sulfate-attachment domain, an acidic amino acid cluster, an EGF-like domain, a transmembrane domain and a cytoplasmic tail. Northern blot analysis revealed that a single transcript of 2.4 kb was detectable in the brain, but not in other human tissues. By fluorescence in situ hybridization (FISH) analysis, the human NGC gene was assigned to the chromosomal 3p21.3 band, where the Sotos syndrome has been mapped. Involvement of the NGC gene in the etiology of the Sotos syndrome remains to be examined. PMID- 9950057 TI - Immunohistochemical localization of serotonin transporter in normal and colchicine treated rat brain. AB - Distribution of serotonin transporter (SET) was examined immunohistochemically in the rat brain using two specific polyclonal antibodies raised against oligopeptides corresponding with 15 amino acids of carboxyl terminus and 14 amino acids of amino terminus of rat SET. The distribution and density of SET immunoreactive varicose fibers were quite similar to those of serotonin immunoreactive fibers, however no neuronal cell bodies in the brainstem raphe nuclei was stained in normal rat brain. Electron microscopic study showed that SET immunoreactivity was predominantly localized in the presynaptic terminals. After intraventricular infusion of colchicine, neuronal perikarya of dorsal, median, and pontine raphe nuclei became visible. These results suggest that SET is likely present at the synaptic terminals of serotonergic neurons and such localization may be in good agreement with its pharmacological action which includes reuptake of serotonin at presynaptic nerve terminals. PMID- 9950059 TI - NMDA receptor-mediated inspiratory off-switching in pneumotaxic-disconnected cats. AB - The pneumotaxic center is thought to govern inspiratory off-switching (IOS), and blockade of N-methyl-D-aspartate (NMDA) receptors by dizocilpine impairs IOS causing apneusis. The present study is to examine whether the NMDA receptor mediated IOS mechanism functions in the medullary respiratory network after disconnecting the pneumotaxic center. In decerebrate and vagotomized cats, the nucleus parabrachialis medialis (NPBM) and vagus nerves were stimulated to evoke IOS and a dorsal pontine transection was performed while the central respiratory activity was recorded in phrenic neurogram. The transection eliminated the NPBM stimulated IOS but not the vagally evoked IOS, and developed two types of respiration; eupnea in 12 and apneusis in six out of 18 cats. Apneustic respiration was not changed into eupneic one by changing the end-tidal CO2 level. In animals displaying eupnea after the transection, dizocilpine (0.3 mg/kg i.v.) produced apneusis, characterized by a prolonged inspiration, a shortened stage 1 expiration and an unchanged stage 2 expiration. Dizocilpine caused no further change in the apneustic pattern induced by the transection. The present results suggest that the medullary respiratory network is able to generate a eupneic respiration after disconnecting the pontine pneumotaxic center, and the NMDA mechanism plays an important role in the medullary respiratory network. PMID- 9950060 TI - Comparison of the expression of two immediate early gene proteins, FosB and Fos in the rat preoptic area, hypothalamus and brainstem during pregnancy, parturition and lactation. AB - Medial preoptic area (MPA), supraoptic nucleus (SON), magnocellular (MaPVN) and parvocellular (PaPVN) paraventricular hypothalamic nuclei, and mesencephalic lateral tegmentum (MLT) are involved in maternal behavior, parturition and lactation. This study investigated the FosB and Fos immunoreactivity in these regions of virgin, pregnant, parturient, lactating, and lactating-arrested rats. The patterns of FosB and Fos expression were compared between the sections taken from the same animals. Quantitative immunohistochemistry revealed a significant increase in the numbers of FosB-positive neurons in the MPA, SON, MaPVN, and MLT of parturient and lactating females as compared with pregnant or virgin animals. In lactating rats, the numbers of FosB-positive neurons in the MPA, PaPVN, and MLT were increased, but the numbers in the SON and MaPVN were decreased as compared with parturient females. Many Fos-positive neurons were also seen in parturient and lactating rats, and the patterns of Fos expression in each region were quite similar to those of FosB. Moreover, double-labeling immunohistochemistry revealed that: (1) many FosB-positive nuclei were observed in oxytocin and vasopressin neurons of the SON and PVN in parturient rats; (2) within FosB-positive neurons, 89.5% in the MPA, 86.8% in the MLT of parturient rats, and 92% in the MPA and 90.8% in the MLT of lactating animals were also Fos positive. Only a small number of FosB and Fos-positive neurons were seen in females that were killed in the early stage of parturition. Removal of the litters immediately after parturition completely eliminated FosB and Fos expression in each region in the dams. Taken together, the present results suggest that FosB expression is co-involved with Fos in the neural activation during parturition and lactation in rats. PMID- 9950061 TI - Postnatal changes in locomotor movements after labyrinthectomy in rats. AB - The influence of unilateral or bilateral labyrinthectomy on the postnatal development of locomotor movements was studied in newborn rats. Locomotor movements of the rats were measured on the surface of a digitizer table by attaching a miniature resonance coil to the abdomen of the rat. Labyrinthectomy was performed in rats on postnatal day (PND) 11. From PND 10 to PND 14, the total distance and mean velocity of locomotor movements were significantly lower in the labyrinthectomized rats than in the control rats. From PND 17 to PND 20, the total distance and mean velocity of the locomotor movements of the unilateral labyrinthectomized rats gradually recovered to an almost normal level. However, those of the bilateral labyrinthectomized rats remained at insufficient levels even at PND 20. PMID- 9950062 TI - Neonatal reversible focal cerebral ischemia: a new model. AB - While numerous animal models exist for studying neonatal brain injury after cerebral ischemia-hypoxia, an adequate model for assessing reversible focal ischemia in the neonatal rat has not been reported. This paper describes in detail a new surgical procedure for creating a non-hemorrhagic, reperfused focal ischemic lesion in the neonatal, 7-day-old rat pup. PMID- 9950063 TI - High-field (3.0 T) functional MRI sequential epoch analysis: an example for motion control analysis. AB - The widely accepted method of blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI) is a subtractive approach of state related analysis based on pictorial statistics, analogous to its predecessor, H2O(15) positron emission tomography (H2O(15)-PET). Although BOLD-fMRI has been shown to have several definite advantages over H2O(15)-PET, it has also been found to be much more artifact prone. This is primarily due to pixel misalignment of raw image data. Furthermore, similar to H2O(15)-PET, conventional means for pictorial analysis in BOLD-fMRI tends to be limited by the relatively low specificity of the observed activation. To overcome this limitation, we investigated a technique for BOLD-fMRI, sequential epoch analysis (SEA), on a high-field (3.0 T) system. The method allows for experimental designs comparable to neurophysiological techniques in primates and enables determination of activation of a selected cerebral cortical region of interest corresponding to a specific task. Utilizing SEA, we successfully identified a specific area within the premotor cortex which is activated complementary to the contralateral hand motion. The findings have strong implications regarding the neurological substrate responsible for the well described clinical phenomenon of physiological mirror movements in infants. The current study validated SEA BOLD-fMRI on a high-field system as a complementary method in the pictorial analysis of conventional fMRI, effectively offsetting the inherent problems of the conventional method, principally pixel misalignment and the relatively low specificity of the observed activation. PMID- 9950064 TI - Simultaneous optical imaging of intracellular Cl- in neurons in different layers of rat neocortical slices: advantages and limitations. AB - Simultaneous recording of changes in intracellular Cl- concentration ([Cl-]i) in individual neurons situated in different layers (e.g. II/III-VI) of neocortical slices was found to be feasible by means of optical fluorescence measurements using 6-methoxy-N-ethylquinolinium iodide (MEQ). Gamma-aminobutyric acid (GABA) caused a measurable increase in [Cl-]i in adult neocortical neurons, but a decrease in immature neurons. Developmental changes in the function of the Cl- pump and cation-Cl- co-transporters were evaluated using inhibitors such as furosemide (FURO), ethacrynic acid (ETA), and bumetanide (BMT). However, it was found that these inhibitors absorb and/or emit light of the wavelength that is used for the optical imaging of MEQ. In addition, quenching of MEQ fluorescence by Cl- and leakage of loaded MEQ was significantly enhanced at a higher temperature, which will limit experimentation at > 30 degrees C. Estimation of [Cl-]i in individual neurons in slices was made possible by calibrating intracellular MEQ fluorescence signals at known Cl- concentrations ([Cl-]) in the presence of tributyltin, a Cl(-)-OH- antiporter, nigericin, a K+-H+ antiporter, and KSCN. This enables comparison of [Cl-]i between neurons in different slices. Thus, optical imaging of [Cl-]i in brain slices can provide valuable spatial information about [Cl-]i dynamics and homeostasis, although it should be emphasized that the technique does have some limitations. PMID- 9950065 TI - Quantitative assessment of auditory cortex responses induced by imager acoustic noise. AB - A clustered volume acquisition functional MRI pulse sequence was modified to assess the response to the acoustic noise of echo-planar imaging in the auditory cortex and to determine whether it is possible to obtain data which is relatively free of acoustic contamination. The spatial location and strength (percent signal change) of cortical responses to the imager noise were examined by introducing extra gradient readouts, without slice excitation, to provide acoustic stimulation immediately prior to acquisition of a cerebral volume. The duration of acoustic stimulation was controlled by varying the number of extra gradient readouts. Slice acquisitions were clustered at the end of the repetition time (TR) period to prevent a response from being induced by the volume acquisition itself ("Intra-Acquisition Response"). The cerebral volumes were acquired using a long TR in order to limit the integration of the cortical response across volume acquisitions ("Inter-Acquisition Response"). Cortical responses were observed to be largest and most significant on the medial two-thirds of Heschl's gyrus, the location of primary auditory cortex. Mean signal changes induced by the imager noise were observed to be as high as 0.95%. A 2 sec delay prior to onset of the BOLD response was empirically determined. These results demonstrate that clustered volume acquisitions may be utilized for up to 2 sec of volume acquisition without inducing an appreciable Intra-Acquisition Response and can be used, with a sufficiently long TR, to provide data which are similarly free of any Inter-Acquisition Response. PMID- 9950066 TI - Improved auditory cortex imaging using clustered volume acquisitions. AB - The effects of the noise of echo-planar functional magnetic resonance imaging on auditory cortex responses were compared for two methods of acquiring functional MR data. Responses observed with a distributed volume acquisition sequence were compared to those obtained with a clustered volume acquisition sequence. In the former case, slices from the volume were acquired at equal intervals within the repetition time, whereas the latter acquired all slices in rapid succession at the end of the imaging period. The clustered volume acquisition provides a period of quiet during which a stimulus may be presented uninterrupted and uncontaminated by the noise of echo-planar imaging. Both sequences were implemented on a General Electric Signa imager retrofitted for echo-planar imaging by Advanced NMR Systems, Inc. The sequences were used to acquire 60 images per slice of a fixed volume of cerebral cortex while subjects were presented an instrumental music stimulus in an On vs. Off paradigm. Data were acquired for both sequences using TR values of 2, 3, 4, 6 and 8 sec. The clustered volume acquisition sequence was found to yield greater measures of dynamic range (percent signal change, mean statistical power per unit imaging time) across the tested range of TR values. Observations of more consistent spatial extent of responses, greater mean signal changes, and higher and more consistent values of mean t-statistic per unit imaging time demonstrate the efficacy of using a clustered volume acquisition for fMRI of auditory cortex. PMID- 9950067 TI - A 15O-H2O PET study of meditation and the resting state of normal consciousness. AB - The aim of the present study was to examine whether the neural structures subserving meditation can be reproducibly measured, and, if so, whether they are different from those supporting the resting state of normal consciousness. Cerebral blood flow distribution was investigated with the 15O-H20 PET technique in nine young adults, who were highly experienced yoga teachers, during the relaxation meditation (Yoga Nidra), and during the resting state of normal consciousness. In addition, global CBF was measured in two of the subjects. Spectral EEG analysis was performed throughout the investigations. In meditation, differential activity was seen, with the noticeable exception of V1, in the posterior sensory and associative cortices known to participate in imagery tasks. In the resting state of normal consciousness (compared with meditation as a baseline), differential activity was found in dorso-lateral and orbital frontal cortex, anterior cingulate gyri, left temporal gyri, left inferior parietal lobule, striatal and thalamic regions, pons and cerebellar vermis and hemispheres, structures thought to support an executive attentional network. The mean global flow remained unchanged for both subjects throughout the investigation (39+/-5 and 38+/-4 ml/100 g/min, uncorrected for partial volume effects). It is concluded that the (H2)15O PET method may measure CBF distribution in the meditative state as well as during the resting state of normal consciousness, and that characteristic patterns of neural activity support each state. These findings enhance our understanding of the neural basis of different aspects of consciousness. PMID- 9950068 TI - Event-related fMRI of tasks involving brief motion. AB - The assessment of brain function by blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) for tasks involving motion near the field of view is compromised by artifacts arising from the motion. The aim of this study is to demonstrate that these artifacts can be reduced by acquiring the average response from a brief stimulus (a "single-trial," or "event-related," paradigm) as opposed to alternating blocks of repeated task with rest (a "block trial" paradigm). The basis of this technique is that the NMR signal changes from neuronal activation are delayed relative to the motion due to a slow hemodynamic response. By acquiring the average response from a brief stimulus, motion-induced signal changes occur prior to neuronal activation-induced signal changes, and the two can thus be distinguished. This technique is applied to the tasks of speaking out loud, swallowing, jaw clenching, and tongue movement. Functional activation maps derived from the single-trial paradigm contain significantly less artifact than functional activation maps derived from a more traditional block-trial paradigm. PMID- 9950069 TI - Adult age differences in the functional neuroanatomy of verbal recognition memory. AB - Adult age differences are frequently observed in the performance of memory tasks, but the changes in neural function mediating these differences are largely unknown. We used (H2)15O positron emission tomography (PET) to measure changes in regional cerebral blood flow (rCBF) during Encoding, Baseline, and Retrieval conditions of a recognition memory task. Twelve young adults (20-29 years) and 12 older adults (62-79 years) participated. During each task condition, participants made a two-choice manual response to each of 64 words. Analyses of the performance data yielded evidence of age-related slowing of encoding and retrieval processes, and an age-related decline in the accuracy of yes/no recognition (d'). The rCBF activation associated with both encoding and retrieval was greater for older adults than for young adults, but this pattern was more clearly evident for memory retrieval. For young adults, rCBF activation during retrieval occurred primarily in right prefrontal cortex, whereas older adults exhibited a more bilateral pattern of prefrontal activation. Regression analyses predicting reaction time in the memory task from regional PET counts confirmed that the neural system mediating memory retrieval is more widely distributed for older adults than for young adults. Both age groups exhibited some decrease in rCBF activation in the second half of the test session, relative to the first half. The practice-related decrease in rCBF activation was more prominent for young adults, suggesting that the older adults' recruitment of additional neural systems reflects a more continual allocation of attention to support task performance. PMID- 9950070 TI - B-SPID: an object-relational database architecture to store, retrieve, and manipulate neuroimaging data. AB - We propose a hardware and software architecture to respond to crucial problems in the neuroimaging field: storage, retrieval, and processing of large datasets. The B-SPID project, here discussed, concerns the processing of neuroimages and attached components stored in an object-relational multimedia database management system (DBMS). Advanced bioinformation concepts are exploited in this project such as large scale data storage, high level graphical user interfaces and 3D graphical processing and display of data. Our database implementation is based on standard programming components, runs on several UNIX platforms and is written to be evolutive. Queries on this database are designed to obtain and display from neuroimaging data several types of results (pictures, text, or 3D graphical shapes) on heterogeneous systems. PMID- 9950071 TI - The dermal acute toxic class method: test procedures and biometric evaluations. AB - A dermal acute toxic class (ATC) method is presented with the use of significantly fewer animals in comparison with the classical dermal 50% lethal dose (LD50) test. The principle of the dermal ATC method is based on the oral and the inhalation ATC method. The method was developed for three fixed starting doses. Depending on the dermal LD50, the slope, the classification system and the starting dose on average 40 to 90% fewer animals will be used in comparison to at least 30 animals with the dermal LD50 test. The method was biometrically evaluated by using the Probit model for dose-response relationships. At present, there are eight different international classification systems based on dermal LD50 values. The test procedures and the calculations of the classification probabilities demonstrate that the dermal ATC method is a reliable alternative to the dermal LD50 test with the use of significantly fewer animals. Classification probabilities are presented for all classification systems currently in use, and expected numbers of experimental and of moribund/dead animals are demonstrated for the system of chemicals in the European Union for all three starting doses. The conclusion is justified that, similarly to the inhalation ATC method, there is no need to validate the dermal ATC method with the use of experimental animals. PMID- 9950073 TI - Body weight loss and changes in tryptophan homeostasis by chlorinated dibenzo-p dioxin congeners in the most TCDD-susceptible and the most TCDD-resistant rat strain. AB - We compared the effects of 2,3,7,8-tetra (TCDD), 1,2,3,7,8-penta (PeCDD), 1,2,3,4,7,8-hexa (HxCDD) and 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD) on brain serotonin metabolism, plasma tryptophan and liver tryptophan pyrrolase activity in two rat strains, TCDD-sensitive Long-Evans (Turku AB; L-E) and TCDD resistant Han/Wistar (Kuopio; H/W). Previously it was shown that L-E rats exhibit the expected rank order of potency for CDDs in terms of acute toxicity with TCDD being the most potent, followed by PeCDD, HxCDD and HpCDD. In contrast, to H/W rats HxCDD was the most toxic and TCDD the least toxic of these congeners. In the present study, the CDDs decreased body weight in L-E rats in the following order of potency: TCDD > PeCDD > HxCDD > HpCDD. The same rank order was recorded for elevations in brain tryptophan and plasma free tryptophan concentrations as well as for inhibition of the main hepatic tryptophan metabolizing enzyme, tryptophan pyrrolase. By contrast, in H/W rats HxCDD was the most effective congener in producing loss of body weight, followed by HpCDD, PeCDD and TCDD. This was also true of changes in tryptophan homeostasis. These findings imply that in TCDD susceptible L-E and TCDD-resistant H/W rats the potency of dioxin congeners in inducing acute toxicity highly correlates with their ability to disrupt tryptophan homeostasis. However, there may not be a direct causal relationship between body weight loss and altered tryptophan homeostasis, because the magnitudes of these two phenomena were not consistently parallel across the dioxin congeners tested. PMID- 9950072 TI - Induction of hepatic mrp2 (cmrp/cmoat) gene expression in nonhuman primates treated with rifampicin or tamoxifen. AB - The multidrug resistance protein 2 (Mrp2) also called canalicular multidrug resistance protein (cMrp) or canalicular multispecific organic anion transporter (cMoat) is a transmembrane export pump located at the canalicular domain of hepatocytes. Mrp2 transports a broad spectrum of organic anions including glucuronides, glutathione conjugates, and organic sulphates into bile. Based on previous observations in rat hepatocytes, the inducibility of mrp2 gene expression in primate liver was investigated in rhesus monkeys treated with tamoxifen or rifampicin. It was found that treatment with tamoxifen (25 mg/kg per day; over 7 days) or rifampicin (15 mg/kg per day; over 7 days) leading to an induction of cytochrome P450 3A4, resulted in a strong increase in mrp2 mRNA in the liver of male and female rhesus monkeys. On the protein level, tamoxifen also was a highly effective inducer, while rifampicin showed some inducing effect in a female and was inactive in a male monkey. In sections of paraffin-embedded liver tissue, immunofluorescence staining confirmed the results of Western blot analysis. Induced Mrp2 was localized to the canalicular domain of the hepatocytes. In conclusion, our data show inducibility of mrp2 gene expression in the liver of primates which may represent an adaptive response aimed at the enhanced biliary elimination of the inducing drugs and/or their metabolites. PMID- 9950074 TI - The peroxisome proliferator nafenopin does not suppress hepatocyte apoptosis in guinea-pig liver in vivo nor in human hepatocytes in vitro. AB - In rats and mice, nafenopin is a nongenotoxic hepatocarcinogen, which induces hepatic DNA synthesis and enzyme induction both in vivo and in hepatocyte cultures in vitro. However, humans and guinea-pigs are considered to be non responsive to the liver growth effects of peroxisome proliferators (PPs). The ability to stimulate cell replication coupled with the ability to suppress apoptosis is thought to underpin the carcinogenicity of nongenotoxic carcinogens such as PPs. Previous studies in this laboratory have shown that in rats in vivo and in vitro nafenopin suppressed spontaneous hepatocyte apoptosis and that induced by the physiological negative growth regulator transforming growth factors beta1 (TGFbeta1). In addition nafenopin suppressed apoptosis in cultured hepatocytes from guinea-pig and hamster. The effects of PPs on apoptosis in human hepatocyte cultures is not known. To correlate these previous in vitro findings to the known species differences in hepatocarcinogenicity of PPs we have investigated the effects of nafenopin on guinea-pig liver growth in vivo. Also, we have examined the effects of nafenopin on apoptosis in cultures of human hepatocytes, a valuable model for human risk assessment. Nafenopin did not inhibit either spontaneous or TGFbeta1 induced apoptosis in human hepatocytes in vitro. Administration of nafenopin to guinea-pigs in vivo produced none of the changes seen previously in responsive species, such as rats and mice. There was no change in liver/body weight ratio, peroxisomal volume of hepatocytes or DNA synthesis as determined by incorporation of bromodeoxyuridine and there was no suppression of apoptosis. The lack of response to nafenopin in guinea-pigs in vivo and human hepatocytes in vitro provides further evidence that these species may be refractory to the liver growth effects of PPs despite the ability of guinea-pigs and humans to respond to PPs by alterations in lipid metabolism. The data presented add to our overall understanding of species differences in response to the PP class of rodent nongenotoxic carcinogens. PMID- 9950075 TI - Suppression of hepatocyte apoptosis and induction of DNA synthesis by the rat and mouse hepatocarcinogen diethylhexylphlathate (DEHP) and the mouse hepatocarcinogen 1,4-dichlorobenzene (DCB). AB - Nongenotoxic rodent hepatocarcinogens do not damage DNA but cause liver tumours in the rat and mouse, associated with the induction of hepatic DNA synthesis. Previously, we have demonstrated that nongenotoxic hepatocarcinogens such as phenobarbitone and the peroxisome proliferator (PP), nafenopin, also suppress rat hepatocyte apoptosis. The nongenotoxic chemicals 1,4-dichlorobenzene (DCB) and the PP, diethylhexyl phthalate (DEHP), both induce high levels of DNA synthesis in rat liver in vivo, but only DEHP is hepatocarcinogenic in this species. Here, we investigate whether the difference in rat carcinogenicity of these two hepatic mitogens may be due to differences in their ability to suppress hepatocyte apoptosis. In rat hepatocytes in vitro, MEHP (the active metabolite of DEHP) induced DNA synthesis 2.5-fold (P = 0.001) and suppressed 10- and 4-fold, respectively both spontaneous (P = 0.0008) and transforming growth factor beta1 (TGFbeta1)-induced (P = 0.0001) apoptosis. DCB gave a small (1.7-fold) increase in DNA synthesis (P = 0.03) and a small (1.7- to 2-fold) suppression of both spontaneous (P = 0.022) and TGFbeta1-induced (P = 0.015) apoptosis. We next analysed the induction of DNA synthesis and the suppression of apoptosis in rat liver in vivo. Both DEHP and DCB were able to induce DNA synthesis although, as seen in vitro, the induction by DCB (4.2-fold; P = 0.023) was less marked than that with DEHP (13.4-fold; P = 0.007). Similarly, DEHP and DCB were both able to suppress rat hepatocyte apoptosis in vivo but the magnitude of the suppression was comparable; apoptosis was reduced to undetectable levels in four out of five animals with DCB and three out of five with DEHP. Since both chemicals suppressed apoptosis and induced DNA synthesis in rat liver but, overall, DCB was less potent, the disparate hepatocarcinogenic potential of these two chemicals could arise from differences in the magnitude of growth perturbation. To test this hypothesis, we repeated the studies in mouse, a species where both DCB and DEHP are hepatocarcinogenic. Both in vitro and in vivo, DCB and DEHP/MEHP were able to suppress apoptosis and induce hepatocyte DNA synthesis in the mouse with comparable potencies. The data support the hypothesis that the carcinogenicity of nongenotoxic hepatocarcinogens is associated strongly with the ability to perturb hepatocyte growth regulation. However, the ability to effect such changes is not unique to nongenotoxic carcinogens and is common to some noncarcinogenic chemicals, such as DCB, suggesting that the growth perturbation may need to exceed a threshold for carcinogenesis. PMID- 9950076 TI - Flow cytometry as a sensitive tool to assess testicular damage in rat. AB - The aim of this study was to compare results obtained by flow cytometry (FCM) with those obtained from testicular histopathology with regard to testicular damage following acute exposure of adult rats to the known testicular toxicant, methoxyacetic acid (MAA). Special emphasis was given to defining the sensitivity of three-parameter FCM compared with testicular histopathology. Furthermore, the effect on the male reproductive system of a single oral dose of MAA was evaluated with traditional methods, e.g. testicular sperm head counts, and organ weights. Adult, male Han/Wistar rats were randomly assigned to four groups of ten animals to be treated with a single dose of 0, 65, 325 and 650 mg MAA/kg body wt. (p.o., gavage). The animals were killed 2 days after treatment, and testicular and epididymal weights were recorded. One testis and the corresponding epididymis were used for histopathology. The other testis was used partly to determine sonication-resistant, testicular sperm-head counts (SHC), and partly for enzymatic digestion followed by FCM. The results obtained in this study are in agreement with the literature, and show that, in the adult male rat, 2 days after administering a single oral dose of MAA, specific depletion of spermatocytes is evident. Detectable testicular effects were produced by the high (650 mg/kg body wt.) and mid (325 mg/kg body wt.) doses, whilst the low dose (65 mg/kg body wt.) did not produce any noticeable effect. There was a strong correlation between results obtained by FCM and those obtained by testicular histopathology, and no difference in sensitivity between the two methods was observed. In summary, three parameter FCM represents a sensitive and reliable method for the detection of testicular injury in the rat. It requires only small amounts of tissue, and the sensitivity was shown to be similar to that of histopathology. Moreover, FCM has the advantages of being quick and objective, which permits large numbers of cells to be analysed. The potential use of this method as a fast screening tool for testicular toxicity in routine toxicology studies should be considered. PMID- 9950077 TI - Mechanism of toxic action of fluoride in dental fluorosis: whether trimeric G proteins participate in the disturbance of intracellular transport of secretory ameloblast exposed to fluoride. AB - In enamel fluorosis model rats treated with sodium fluoride, secretory ameloblasts of incisor tooth germs exhibited disruption of intracellular trafficking. We examined whether heterotrimeric G proteins participated in the disruption of vesicular trafficking of the secretory ameloblast exposed to fluoride, using immunoblotting and pertussis toxin (IAP)-induced adenosyl diphosphate (ADP)-ribosylation for membrane fractions of the cell. Immunoblotting of crude membranes, post supernatants of the ameloblast, with anti-G(alpha i3/alpha o) and anti-G(alpha s) antibodies showed that Gi3 or Go proteins existed in the secretory ameloblast, but Gs protein did not. Immunoblotting of the subcellular membrane fractions indicated that the Gi3 or Go proteins were located in the Golgi membrane, but were not in the rough endoplasmic reticulum (rER) membrane. Autoradiograph of IAP-induced ADP-ribosylation, however, showed the existence of IAP-sensitive G proteins both in rER and Golgi membranes. Fluoride treatment decreased the G proteins bound to both membranes. These findings indicate that different G proteins, both of which are IAP-sensitive, are present in the rER and Golgi apparatus, and suggest that these G proteins participate in the disturbance of intracellular transport of the secretory ameloblast exposed to fluoride. PMID- 9950078 TI - Modelling of residual variability in toxicokinetic studies with sparse sampling: the case of tetrahydronaphthalene. AB - The present study describes the kinetics of tetrahydronaphthalene in male and female rats (five animals per dose per sex) at three dose levels (15, 50, and 150 mg/kg daily). Plasma concentration measurements were performed in the course of a subacute toxicity study of 28 days duration in an enriched study design. Two blood samples per animal were taken at different time points after application at day 1 and 16 (150 mg/kg daily) and at day 3 and 18 (15 and 50 mg/kg daily), respectively. Tetrahydronaphthalene was assayed by gas chromatography-mass spectrometry (GC-MS) after extraction. The data of plasma concentration time were analysed using non-linear mixed effects modelling as implemented in NONMEM. The structural model with the best fit employed one compartment kinetics with instantaneous drug input. Interindividual variability in both k and V was found to be very small [k, 0.201 h(-1), 0.013; V, 16.19 (kg), 1.77; population mean and SE]. No unequivocal evidence of dose dependence could be found. The kinetic parameter with the highest extent of variability was the extent of bioavailability which showed an coefficient of variation (CV) of 96%. Both gender and dose had no influence on the variability. The present approach is concluded to offer more insight into the relationship between dose, concentration and effect and into factors which explain variability in kinetics without additional testing or additional animals. Proposals for a refined sampling schedule are made. PMID- 9950079 TI - Determination of glutathione transferase (GSTT1-1) activities in different tissues based on formation of radioactive metabolites using 35S-glutathione. AB - A new system has been developed to determine enzyme activities of glutathione transferase theta (GSTT1-1) based on radiometric product detection resulting from the enzymic reaction of methyl chloride with 35S-labelled glutathione. In principle, the method is universally applicable for determination of glutathione transferase activities towards a multiplicity of substrates. The method distinguishes between erythocyte GSTT1-1 activities of human 'non-conjugators', 'low conjugators' and 'high conjugators'. Application to cytosol preparations of livers and kidneys of male and female Fischer 344 and B6C3F1 mice reveals differential GSTT1-1 activities in hepatic and renal tissues. These ought to be considered in species-specific modellings of organ toxicities of chlorinated hydrocarbons. PMID- 9950080 TI - Interaction of vitamin C and flavonoids in elderberry (Sambucus nigra L.) during juice processing. AB - A field experiment and two oxidation experiments in the laboratory were carried out. The content of the major anthocyanins, cyanidin-3-glucoside (Cy-3-G) and cyanidin-3-sambubioside (Cy-3-Sa), in the fresh fruits from the 13 cultivars were from 361 to 1266 and from 269 to 656 mg/100 g, respectively. The two minor anthocyanins, cyanidin-3-sambubioside-5-glucoside (Cy-3-Sa-5-G) and cyanidin-3.5 diglucoside (Cy-3.5-dG), occurred in concentrations between 5 and 47 mg/100 g. The content of ascorbic acid and quercetin in the fresh fruits of the cultivars varied from 6 to 25, and from 29 to 60 mg/100 g, respectively. Purging of the elderberry juice with N2 and/or addition of ascorbic acid reduced the oxidative degradation rate of the two major anthocyanins and quercetin. Ascorbic acid protected the anthocyanins, but not quercetin from oxidative degradation. Mixing of fruits with air during processing and even a low content of oxygen in the juice before tapping must be avoided by appropriate steps during processing. Improvement of the nutritional value of the elderberry juice and increased protection of anthocyanins against oxidative degradation may potentially be obtained by selection of cultivars with a high content of ascorbic acid. PMID- 9950081 TI - Impact of microwave heating on hemagglutinins, trypsin inhibitors and protein quality of selected legume seeds. AB - Selected legume seeds (dry and soaked) including faba beans, peas, chickpeas, soybeans, lentils and common beans containing 8 and 25% moisture, respectively, were subjected to microwave heating, and to a conventional cooking method to determine the heating effect on toxic compounds and protein quality. Trypsin inhibitors, hemagglutinins and available lysine were analyzed, and laboratory rats were used to determine digestibility and protein efficiency ratio (PER). Results indicated that microwaving destroyed trypsin inhibitors to a similar degree to that observed in beans cooked using the conventional method without affecting PER for raw seeds with low antinutrients content (faba beans, peas, chickpeas and lentils). Microwave-heated soaked soybeans had a higher amount of destroyed trypsin inhibitors, along with a higher PER, compared with microwave heated dry soybeans. Microwave heating of common beans failed to destroy hemagglutinins and trypsin inhibitors, and consequently their digestibility and PER values were poor. Finally it was concluded that microwave heating constitutes an adequate method for destroying hemagglutinins and trypsin inhibitors without affecting protein quality of most legume seeds, except for common beans that despite of this process retained the antinutritional substances. PMID- 9950083 TI - Selected nutritional components and sensory attributes of cowpea (Vigna unguiculata [L.] Walp) leaves. AB - Reports on the nutritional composition of cowpea leaves have been limited to a small number of lines and the palatability characteristics of leaves apparently have not been studied. This study was therefore undertaken on cowpea leaves to determine the nutrient composition of fifteen varieties and the sensory attributes of ten varieties grown in Ghana. Nutritional components studied were moisture, protein, phosphorus and ascorbic acid. The sensory attributes included leaf size, taste and overall acceptability. There were significant (p > 0.05) differences among varieties in all nutrient components (fresh and dry weight basis), leaf size and overall acceptability. The nutrient composition values, on a dry weight basis, ranged from 9.4 to 13.0% for moisture, 303.8 to 468.9 mg/100 g for phosphorus, 33.5 to 148.0 mg/100 g for ascorbic acid, and 27.1 to 34.7% for protein. Differences in the sensory scores of leaves for taste were not significant (p > 0.05). Overall acceptability positively correlated with leaf size. Moisture content was negatively correlated with overall acceptability, phosphorus and ascorbic acid. Results can be exploited in a breeding program to develop nutritionally superior and acceptable cowpea varieties which can be used for harvesting of both leaves and seeds. PMID- 9950082 TI - Effect of in utero exposure of Toddy (coconut palm wine) on liver function and lipid metabolism in rat fetuses. AB - The objective of this study was to determine the effects of a country liquor Toddy (Coconut palm wine) and an equivalent quantity of ethanol on liver function and lipid metabolism in utero. Female albino rats with an average weight of 125 +/- 5 g were exposed to Toddy from coconut palm (24.5 ml/kg body weight/day) and ethanol (0.52 ml/kg body weight/day) for 15 days before conception and during pregnancy. On day 13 and day 19 of gestation, altered liver function and hyperlipidemia were seen in the fetuses of both the treated groups. Altered liver function was evidenced by the increased activity of alcohol dehydrogenase, aldehyde dehydrogenase, glutamic oxaloacetic transaminase (aspartate amino transferase (GOT)), glutamic pyruvic transaminase (alanine amino transferase (GPT)). Hyperlipidemia was caused by increased biosynthesis since the incorporation of 14C acetate into lipids and activities of HMG CoA reductase and lipogenic enzymes were elevated. Toddy treated fetuses were more severely affected than those exposed to an equivalent quantity of ethanol. Toddy seemed to potentiate the toxicity induced by alcohol suggesting the role of non alcoholic components. Hepatic functions of the day 13 fetuses were effected to a lesser degree than those in the day 19 hepatic liver. PMID- 9950084 TI - Toxicity studies in mice of common spices, Cinnamomum zeylanicum bark and Piper longum fruits. AB - Acute (24 hours) and chronic (90 days) oral toxicity studies on the ethanolic extracts of common spices Cinnamomum zeylanicum Nees bark and Piper longum L. fruits were carried out in mice. Acute dosages were 0.5, 1.0 and 3 g/kg while the chronic dosage was 100 mg/kg/day. All external morphological, hematological and spermatogenic changes, in addition to body weight and vital organ weights, were recorded. The extracts of both the plants caused no significant acute or chronic mortality compared to the control during this study. During chronic treatment there was no significant change in the pre- and post treatment body weight of the test animals while the weight gain in the control group was significant. C. zeylanicum treatment caused reduction in liver weight while P. longum caused a significant increase in the weight of the lungs and spleen of the treated animals compared to the control. Hematological studies revealed a significant fall in hemoglobin level of C. zeylanicum treated animals. Both of the extracts induced a significant increase in reproductive organ weights, sperm motility, sperm count and failed to illicit any spermatotoxic effect. PMID- 9950085 TI - Yield, protein, and oil quality of soybean genotypes selected for tofu production. AB - The soyfood industry prefers some soybean [(Glycine max L. (Merr.)] cultivars over others based on chemical constituents, physical traits, and processing quality of the seed. However, soybean cultivars possessing the combination of desirable agronomic traits and biochemical characteristics that enhance the quality of soyfoods have not been identified in the USA. Thus, this research was conducted with the objective of determining yield, seed protein, and fatty acid composition of soybean genotypes selected for tofu production. Twelve soybean genotypes were planted in plots arranged in a randomized complete block design with four replications at the Agricultural Research Station, Fort Valley State University, Georgia, USA during 1994 and 1995. Seed yield ranged from 1.6 to 3.0 metric tons/ha. The protein content varied between 314.2 and 480.7 g/kg seed. Both BARC-8 and BARC-9 had significantly higher protein content than other genotypes. These two genotypes also showed significant year by genotype interactions for some fatty acids. V71-370 had the highest oleic acid concentration and a high ratio (0.92) of monounsaturated to polyunsaturated fatty acids. The concentration of linoleic and linolenic acids ranged from 406.5 to 531.0 and 37.1 to 63.0 g/kg oil, respectively. Seed yield was correlated with biomass, harvest index, and filled pods per m2. In this study, V71-370 was found to be relatively superior in oil quality with fatty acid composition desirable for human consumption. The significant variation for seed yield and biochemical characteristics observed among the few genotypes examined in this study indicates the potential for breeding high yielding soybean cultivars suitable for soyfoods. Therefore, there is a need for evaluation of soybean germplasm for agronomic traits that contribute to seed yield and biochemical characteristics including fatty acid profiles that enhance soyfood quality before initiating development of suitable cultivars for tofu. PMID- 9950086 TI - Antioxidative activities in some common seaweeds. AB - Dietary antioxidants from plants are believed to help prevent aging and other diseases through radical scavenging activity. Free radical scavenging activities by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay and deoxyribose assay were ascertained among 27 species of common seaweeds using a sequential extraction method. The results indicated that, DPPH scavenging activity existed in 15 species; Gelidium amansii, Gloiosiphonia capillaris, Polysiphonia urceolata, Sargassum kjellmanianum, Desmarestia viridis, and Rhodomela teres showed the strongest activities. On the other hand, the deoxyribose results showed that almost all the seaweed species had good ability to scavenge hydroxyl radicals. The most active species were Rhodomela teres and Chorda filum. PMID- 9950088 TI - Development and acceptability of a ready-to-eat beta-carotene rich, maize based supplementary product. AB - Low cost supplementary products using maize were developed and made using extrusion. Beta-carotene rich sources like curry leaf, carrot, red palm oil were used at different level to increase vitamin A precursor Levels and, therefore, vitamin A. Incorporation of curry leaf powder and carrot powder at 30 percent level and 30:70 blend of red palm oil and groundnut oil were found to be more acceptable than the products made with other levels. These products were tasted for acceptability by preschool children and were analysed for energy, protein, fat and beta-carotene contents. The control, fresh and stored supplementary products contained 1.707, 1.922, 1.919 MJ, 11.0, 11.6, 10.36 g protein, 10.2, 10.4, 9.64 g fat, 0, 7.37, 6.72 mg beta-carotene per 100 g, respectively. The loss of beta-carotene in processing and storage of curry leaf and carrot supplemented products was 13.69, 6.25 and 20.24, 8.06 percent, respectively. PMID- 9950087 TI - Composition of pulp, skin and seeds of prickly pears fruit (Opuntia ficus indica sp.). AB - The proximate composition of pulp, skin and seeds of prickly pear cactus (Opuntia ficus indica) was investigated and is reported on a dry weight basis. The most abundant component of the pulp and skin was ethanol-soluble carbohydrates. Pulp contained glucose (35%) and fructose (29%) while the skin contained essentially glucose (21%). Protein content was 5.1% (pulp), 8.3% (skin) and 11.8% (seeds). Starch was found in each of the three parts of the fruit. Pulp fibers were rich in pectin (14.4%), skin and seeds were rich in cellulose (29.1 and 45.1%, respectively). Skin was remarkable for its content of calcium (2.09%) and potassium (3.4%). Prickly pear is a neglected nutritional source which should be more widely used because of its potential nutrient contribution. PMID- 9950089 TI - How should the safety and efficacy of platelet transfusions be assured? PMID- 9950090 TI - Diagnosis and treatment of patients refractory to platelet transfusions. PMID- 9950091 TI - The ideal platelet prescription. PMID- 9950092 TI - Indications for therapeutic platelet transfusions. PMID- 9950093 TI - Trigger factors for prophylactic platelet transfusion. AB - The level of 20x10(9)/L for prophylactic platelet transfusion has rightly been challenged over the last few years, with some units recommending a level as low as 5x10(9)/L. The higher levels are usually based on retrospective data from the 1950s. We examined the more recent data and came to the conclusion that a threshold of 10x10(9)/L is safe in the stable patient; higher levels are recommended for specific clinical circumstances. This threshold will reduce donor exposure, costs and possibly donor alloimmunization. The dearth of prospective controlled clinical trials in the literature also presents an opportunity for both in-house and national audit. PMID- 9950094 TI - Consensus conference on platelet transfusion. Final statement. PMID- 9950095 TI - Diagnosis and prevention of fungal infection in the immunocompromized patient. AB - Profound and prolonged neutropenia following chemotherapy is a major risk factor for systemic fungal infections. Mortality associated with disseminated fungal infection is high and treatment with conventional amphotericin B is complicated by renal toxicity. Candida and Aspergillus are among the major pathogens in this patient population. Many patients remaining neutropenic over a prolonged period of time will receive empirical antifungal therapy. The clinical and laboratory diagnosis of these infections are neither sensitive nor specific and are generally limited in the early detection of invasive fungal infection. However, several new approaches to diagnosis are being developed which should be translated into routine practice. These include antigen detection and PCR. It is still unclear how effective the various measures that are currently being used are in preventing serious fungal infection. Refinements in the prophylactic use of fluconazole, itraconazole and aerosolized amphoteric in B, and the introduction of new formulations of existing antifungals may reduce the incidence of systemic fungal infections in some patient groups. Patients with presumed fungal infection require more intense and accurate monitoring for signs of disseminated infection. Early diagnosis may guide appropriate treatment and prevent mortality. PMID- 9950096 TI - New-variant Creutzfeldt-Jakob disease: the risk of transmission by blood transfusion. AB - New-variant Creutzfeldt-Jakob disease (nvCJD) was first described in the UK in 1996 and is thought to be related to the consumption of cattle suffering from bovine spongiform encephalopathy. Although only 29 cases have been confirmed to date, it is too early to predict the number of people who may currently be incubating the disease. Past experience suggests that sporadic CJD is rarely, if ever, spread by blood transfusion. However, it is unclear whether nvCJD may be transmissible by this route and if so, how easily. Assessing the potential risk of transmission of nvCJD by blood transfusion and evaluating the likely efficacy of proposed strategies to reduce this risk is, therefore, very difficult. This article summarizes the spectrum of transmissible spongiform encephalopathies in animals and man, the molecular and cellular biology of the prion protein and the continuing debate as to the nature of the infectious agent. The distribution of normal prion protein expression, the results of experimental transmission studies and the case reports and clinical studies on CJD transmission are reviewed. Finally, the extent of current knowledge and the potential utility of proposed strategies to reduce the risk of nvCJD transmission by blood transfusion are discussed. PMID- 9950097 TI - Analysis of effector cells in tumor-bearing mice pre-treated with active specific immunization followed by cyclophosphamide. AB - In order to analyse the effector population in an immunization model, we treated BALB/c mice with intraperitoneal (i.p.) active specific immunization (ASI), which consists of interleukin (IL)-1-beta and sonicated tumor supernatant (SS) of a plasmacytoma MOPC-104E followed by i.p. injection of cyclophosphamide (CY). This ASI-CY treatment provoked a protective immunity against i.p. tumor inoculation more strongly than that of ASI alone. The main effector cells in tumor neutralizing assay were CD4+ T cells at this pont. The number of spleen cells of the ASI-CY treated mice were significantly lower than that of ASI alone treated mice but it increased significantly 6 days thereafter while this increase was not observed on the mice treated with ASI alone. The spleen cells of the ASI-CY treated mice responded to SS in vitro in the presence of IL-2, more profoundly in CD4 enriched population which produced high amount of TNF-alpha. In vivo tumor neutralizing activity at a later stage was dependent on CD8+ T cells in addition to CD4+ T cells. These results suggest that antitumor activity by ASI and CY is transduced by sequential population shift from CD4 alone to both of CD4 and CD8. PMID- 9950098 TI - Low dose oral interferon alpha 2a in HIV-1 seropositive patients: a double-blind, placebo-controlled trial. AB - Low dose oral interferon alpha has been shown to be of benefit in viral disease in animals. In a double-blind, placebo-controlled trial, 177 patients seropositive for HIV-1 were randomly assigned to receive placebo or recombinant human interferon alpha 2a (rIFN alpha). Endpoints were survival, alteration of disease classification, performance, and changes in CD4+ T cell numbers. There was a trend for improved survival in the group receiving rIFN alpha at the dose of 1.0 IU/lb. The changes in disease classification or in weight were not significantly different. Performance was improved to a greater extent (p=0.1) in the patients who received the two higher rIFN alpha dosages (1.0 IU/lb and 10.0 IU/lb) at 6 months. In addition, the CD4+ T cell count was improved only in the 1.0 IU/lb dose treatment group at 6 months. Treatment with low dose oral interferon at 1.0 IU/lb was associated with improved CD4+ T cell count, performance and a trend toward enhanced survival in HIV seropositive patients. These differences were, however, not statistically significant. A larger study, with better return rate, will be needed to determine whether low dose, oral interferon alpha is actually beneficial for these patients. PMID- 9950099 TI - Effect of herbal therapy on herpes labialis and herpes genitalis. AB - Administration of hot water extracts of six herbs to four patients with recurrent herpes labialis led to prompt crusting over and complete recovery within a few days. Similar treatment for one female patient who had been suffering from recurrent genital herpes resolved the associated pain dramatically. In all cases mentioned, symptoms disappeared much more quickly than with previous outbreaks when herb extracts were not administered. PMID- 9950100 TI - The use of BRM-activated killer cells in adoptive immunotherapy: a pilot study with nine advanced cancer patients. AB - Adoptive immunotherapy using MHC-nonrestricted-lymphocytes, peripheral blood gammadelta T cells and NK cells was devised. Peripheral blood mononuclear cells (3 x 10(7)) were selected by immobilization to anti-CD3 monoclonal antibody for 4 days and cultured for 2 weeks in the presence of IL-2. Thereafter they were reactivated by 500 U/ml of IFN-alpha and 1000 U/ml of IL-2 for 1 hour. Enhancement of NK and LAK activities was confirmed. Peripheral blood gammadelta T cells proliferated in response to immobilized anti-CD3 antibody (3% to 30%). Approximately 6 x 10(9) BRM-activated killer (BAK) cells composed of CD56+ gammadelta T cells and CD56+ NK cells, were dispensed to cancer patients via intravenous drip infusion. Nine patients were treated with BAK cells every 2 weeks or every month on an outpatient basis. During the course of adoptive immunotherapy, the crossed affinity immunoelectrophoresis (CAIE) pattern of serum immunosuppressive acidic protein (IAP) was analysed. Both the production and glycosylation pattern of IAP is changed in response to tumor enlargement and may therefore act as a marker of the disease progression. During the course of BAK therapy, the glycosylation IAP pattern of 6 patients changed from tumor (T) to normal (N). In addition, the performance status of all patients was maintained at 90-100% of the Karnofsky scale and any side effects including fever were not observed during treatments with BAK cells. Moreover, the overall quality of life (QOL) of the patients, scored at the Face scale was favorable. In addition, blood levels of activated gammadelta T cells producing IFN-gamma were assayed as an indication marker of BAK therapy. The normal range of IFN-gamma producing gammadelta T cells comprised 6.9 +/- 0.9% of peripheral blood mononuclear cells (PBMC), according to a single cell FACScan analyses of PBMCs derived from normal individuals. IFN-gamma producing gammadelta T cells of Patients No. 8 and 9, who received extensive chemotherapy before initiation of BAK therapy, comprised only 0.2% and 2% of PBMC, respectively. These patients died 3 and 6 months after beginning BAK therapy. Peripheral blood gammadelta T cells of Patients Nos. 1-7 proliferated in response to immobilized anti-CD3 antibody and the frequency of IFN-gamma producing gammadelta T cells in PBMC preparation of these patients were over 3% before initiation of BAK therapy. Since our data show a positive correlation between survival time and initial gammadelta T cell counts, a low frequency of these cells may contraindicate BAK therapy. PMID- 9950101 TI - Levamisole and interleukin-2 for advanced malignancy. AB - Therapy for cancer patients with biologically active immune modulators is attractive but has met with limited clinical success. Interleukin-2 (IL2) stimulates T-cells and natural killer (NK) cells to kill tumor cells and levamisole (LMS) is an immunostimulant which has been shown to increase NK cells and activated T-cells in patients receiving this adjuvantly along with 5FU for Stage III colon cancer. This study was designed to evaluate whether treatment with LMS prior to IL2 would provide synergistic activity and improve response rates. Four patients with advanced malignancies were treated with LMS at 50 mg p.o. TID for 3 days followed on day 4 with 600,000 units/kg IL2 as a single i.v. bolus. This treatment was repeated weekly until progression. Serum soluble IL2 receptor (sIL2R) and interferon-gamma levels were monitored throughout the treatment course as markers of immune activation. All patients had eventual progression of disease. Toxicity was minimal with Grade II orthostatic hypotension the major consequence of therapy. The pattern of sIL2R levels in 3/4 patients revealed a steady increase over the several weeks of therapy, indicating ongoing immunostimulation (r=0.53 , p=0.001). Short-term treatment with LMS, however, resulted in a significant and consistent decreases in sIL2R levels (2198 U/ml vs. 1969 U/ml, p=0.001) in all patients. In conclusion, LMS/IL2 in the dose and schedule utilized here was not clinically effective. However, LMS reduced sIL2R levels immediately following a three-day course. This reduction in sIL2R by LMS may improve the possibility of response to IL2 by facilitating a decrease in inhibitory sIL2R. Combinations of these two agents should continue to be investigated as potential synergistic anti-tumor agents. PMID- 9950102 TI - Antitumor effect of a peptide-glucan preparation extracted from Agaricus blazei in a double-grafted tumor system in mice. AB - The antitumor effect of extracts obtained from the fruit body of Agaricus blazei Murill was examined in a double-grafted tumor system, in which BALB/c mice received simultaneous intradermal injections of Meth-A tumor cells in both the right (10(6) cells) and left flank (2 x 10(5) cells), and were then injected with 5 mg of extracts of A. blazei in the right tumor on days 3, 4 and 5. Intratumoral administration of ethanol-soluble (Fraction 1), water-ethanol-soluble (Fraction 2), ammonium oxalate-soluble (Fraction 3) and ammonium oxalate-insoluble (Fraction 4) fractions resulted in inhibition of tumor growth, with Fraction 3 showing the most tumoricidal activity, producing regression of the right tumor and inhibition of growth of the left, non-injected tumor. The maximum effect was obtained using 0.5 mg of Fraction 3 and this amount was used in subsequent experiments. The antitumor effect of intratumorally administered Fraction 3 was enhanced by oral ad lib administration of feed containing 0.083% of Fraction 3. When immunized spleen cells from mice that had been cured by intratumoral administration of 0.5 mg of Fraction 3 were directly injected (2 x 10(7) cells/mouse) into the Meth-A tumor, tumor growth was inhibited. The tumor cells on day 7 from the Fraction 3-treated right tumor and from the left tumor were cultured for 24 h and their culture supernatants were assayed for neutrophil or macrophage chemotactic activity. Significant macrophage chemotactic factor activity was detected in the culture media from the left tumor tissue. Serum levels of immunosuppressive acidic protein (IAP), produced by activated macrophages and neutrophils, increased transiently soon after intradermal injection of 0.5 mg of Fraction 3. These results suggest that regression of the left non-injected tumor was due to an immune reaction, involving induction of cytotoxic cells in the spleen, and the release of chemotactic factors in the distant tumor. PMID- 9950103 TI - Contribution of cytokines on the suppression of lung metastasis. AB - Weekly injection of a protein-bound polysaccharide PSK in mice with Lewis Lung Cancer (LLC) significantly decreased the number of lung metastatic foci concomitant with enhancement of cytostatic activity in the bronchoalveolar lavage (BAL) cells. These effects were more marked when the agent was given intratracheally, inducing a larger number of pulmonary macrophages, lymphocytes and neutrophils concomitant with increases in BAL tumor necrosis factor-alpha (TNF-alpha), mouse inflammatory protein-alpha (MIP-1alpha), mouse inflammatory protein-beta (MIP-1beta), interleukin-1alpha (IL-1alpha) and interleukin-6 (IL 6), but not interleukin-2 (IL-2) and interleukin-4 (IL-4). Pre-treatment with anti TNF-alpha antibody reduced these effects. The time course and production of PSK-induced cytokines were similar between the tumor-bearing mice and control mice. BAL neutrophils in mice with LLC showed a tendency toward acceleration of O2- production compared with circulating neutrophils. Pulmonary macrophage phagocytosis was also significantly higher in the LLC mice. These results suggest that enhancement of cytostasis appears to be induced by activation and/or improvement of function in inflammatory and immune cells through cytokines under immunomodulator treatment in lung metastasis, possibly via a TNF-alpha-dependent mechanism. PMID- 9950104 TI - Elevated serum level of thioredoxin in patients with hepatocellular carcinoma. AB - Thioredoxin (TRX) is known to contain an active site with a redox-active disulfide and has various biological activities. The objective of the present study was to investigate whether circulating TRX levels are elevated in patients with chronic hepatitis (CH) or liver cirrhosis (LC) and hepatocellular carcinoma (HCC). An anti-TRX monoclonal antibody and polyclonal antibodies that specifically recognize TRX, were generated and used for the development of an ELISA system to measure TRX levels in human serum. The geometric mean and its 95% confidence interval of serum level of TRX in healthy volunteers was 81.75 ng/ml (74.60-89.59 ng/ml). The serum level of TRX in LC/CH patients without HCC was 80.87 ng/ml (69.66-93.88 ng/ml). The value was not statistically different from that in serum from normal volunteers (p=0.69). In contrast, the serum level of TRX in patients with HCC was 147.35 ng/ml (125.53-172.96 ng/ml), which was significantly higher when compared with the level in serum of normal volunteers (p<0.001) and in serum of LC/CH patients without HCC (p<0.001). In four patients with HCC, the initially high level of serum TRX (>150 ng/ml) decreased below 150 ng/ml after surgical removal of the tumor. The data reported herein revealed that patients with HCC had a significantly elevated serum level of TRX, suggesting that measurement of serum of TRX might be a useful clinical parameter when HCC is suspected. PMID- 9950105 TI - Cytokine effect on ex vivo expansion of haemopoietic stem cells from different human sources. AB - Human pluripotential stem cells (PSC) are currently the target for transplantation attempts and genetic manipulation. We have therefore investigated the frequency and the expansion potential of PSC's in different types of blood samples. CD 34+ cells were thus obtained from human bone marrow (BM), as well as from peripheral blood (PB) and cord blood (CB) samples. After immuno-magnetic separation the highest yields of CD 34+ cells were from BM (1.08-2.25%) and CB (0.42-1.32%) while PB samples gave much lower values. Suspension cultures of PSC's from the three sources were then set up, in the presence of combinations of haemopoietic growth factors. A remarkable amplification of the nucleated cell pool was observed reaching a maximum between 10 and 15 days of culture; earliest and maximum expansion (up to 220-fold) was achieved when Erythropoietin (Epo) was added to the culture medium, but this resulted in reduction of colony-forming cells and differentiation into erythroid progenitors. Clonogenic tests for BFU E's derived colonies showed a peak value at 5 days of liquid culture. Further studies are advisable to establish the best cytokine combination for a valuable ex vivo expansion, coupled with preservation of stem cell properties. PMID- 9950106 TI - Canalplasty for chronic tympanic membrane atelectasis. AB - PURPOSE: Canalplasty to prevent accumulation of squamous debris has been proposed as an alternative to tympanoplasty for the treatment of tympanic membrane atelectasis and early cholesteatoma. The goal of this article is to report our experience with canalplasty for the treatment of advanced middle ear atelectasis. MATERIALS AND METHODS: A retrospective review was performed on all patients that underwent tympanoplasty or canalplasty at the University of Florida since 1992. Eight ears (seven patients) with severe atelectasis were found to have been treated with canalplasty (without middle ear reconstruction) to marsupialize the retraction pockets. RESULTS: Follow-up was conducted at an average of 22 months. Four ears required repeat surgical intervention after an average of 12 months: three required canal wall down mastoidectomies for cholesteatoma, and a tympanoplasty was necessary in one case for persistent perforation. Four ears not requiring revision were without cholesteatoma or perforation at an average follow up time of 26 months. Mean audiometric thresholds were stable or improved, irrespective of the need for revision surgery. CONCLUSIONS: Canalplasty may be an alternative for the treatment of atelectasis in selected patients; however, close follow-up after surgery is necessary because of the potential for progression to cholesteatoma. PMID- 9950107 TI - Azithromycin versus amoxicillin/clavulanate in the treatment of acute sinusitis. AB - PURPOSE: To compare the efficacy and tolerability of a 3-day course of azithromycin with a 10-day course of amoxicillin/clavulanic acid in the treatment of acute sinusitis in adults. PATIENTS AND METHODS: One hundred adult patients with acute sinusitis were included in an open, randomized study. Clinical diagnosis of sinusitis was confirmed by nasal endoscopy, sinus radiography, and (when possible) by culture of sinus aspirate. Patients were randomized to receive azithromycin (500 mg once daily for 3 days) or amoxicillin/clavulanate (625 mg every 8 hours for 10 days). RESULTS: A significantly faster resolution of signs and symptoms of sinusitis was observed in the azithromycin-treated patients. By the end of therapy (days 10-12), 95% of the patients in the azithromycin group and 74% in the amoxicillin/clavulanate group were cured. The remaining patients' conditions were improved. By the follow-up visit, cure was achieved in 98% of the azithromycin-treated patients, and 91% of the amoxicillin/clavulanate-treated patients. Treatment failure was observed in three patients from the amoxicillin/clavulanate group, and relapse occurred in one patient from each group. Bacteriologic eradication was achieved in 23 of 23 and 21 of 24 patients treated with azithromycin and amoxicillin/clavulanate, respectively. Both drugs were well tolerated. Two patients (4%) from the azithromycin group and five patients (10%) from the amoxicillin/clavulanate group reported mild gastrointestinal disturbances. CONCLUSIONS: In adults with acute sinusitis, a 3 day course of azithromycin was as effective and well tolerated as a 10-day course of amoxicillin/clavulanic acid. A significantly simpler dosage regimen and faster clinical effect were the advantages of azithromycin. PMID- 9950108 TI - Otorrhea after grommet insertion for middle ear effusion in patients with nasopharyngeal carcinoma. AB - PURPOSE: To document the incidence of complications after myringotomy and grommet insertion in patients with nasopharyngeal carcinoma. The focus is on the incidence of otorrhea and perforation. The possible risk factors for these conditions and treatment response were studied. MATERIALS AND METHODS: We reviewed the records on 206 ears of 163 patients who suffered from nasopharyngeal carcinoma and underwent myringotomy and grommet insertion in a 7-year period. The follow-up period ranged from 4 weeks to 78 months (median, 9 months). RESULTS: The overall incidence of otorrhea in these ears was 38%. Patients with nasopharyngeal carcinoma (NPC) had a significantly high incidence of postoperative discharge (chi2 test, P<.0001) compared with other patients who underwent myringotomy and grommet insertion. The mean interval between myringotomy and otorrhea was 19.8 weeks. Forty-seven per cent of the ears with a discharge developed otorrhea within 1 month. In 42%, the otorrhea responded to treatment and the ears became dry. After extrusion of the grommet, 29% of those ears with otorrhea ended with an eardrum perforation, and 24% of the ears showed recurrent effusion. CONCLUSIONS: For patients with NPC who underwent myringotomy, there was a significant risk of otorrhea (49%) and persistent perforation (29%), and these complications were difficult to manage. We conclude that myringotomy and grommet insertion should not be routinely offered to NPC patients with middle ear effusion. PMID- 9950110 TI - The treatment of macroglossia before the 20th century. PMID- 9950109 TI - Otolaryngologic complications of the anterior approach to the cervical spine. AB - PURPOSE: To review current literature regarding otolaryngologic complications of the anterior approach to the cervical spine with the focus on the etiology, diagnosis, and treatment of these disorders. METHODS: A review of literature from the introduction of anterior cervical surgery (late 1950s) to the present was conducted by using computer databases and bibliographies of appropriate journal articles and texts. Key words included "anterior cervical surgery," "dysphagia," "surgical complications," and "hoarseness." CONCLUSION: Dysphagia and dysphonia are common conditions following anterior cervical fusion, and patients should be counseled on this risk preoperatively. The etiologies of these problems have not been clearly elucidated, and these complications are frequently underreported or ignored. Otolaryngologic consultation should be obtained for all patients with dysphagia or dysphonia that persists longer than 1 to 2 months, and consideration should be given to having all patients at risk (previously operated patients) evaluated both preoperatively and postoperatively. PMID- 9950111 TI - Management of patients after elective carotid artery resection. PMID- 9950112 TI - Wegener's granulomatosis presenting as facial palsy. PMID- 9950113 TI - Major vascular injuries in children undergoing myringotomy for tube placement. PMID- 9950114 TI - Management of buccal space tumors by rhytidectomy approach with superficial musculoaponeurotic system reconstruction. AB - PURPOSE: To show that the rhytidectomy approach without a submandibular limb can be successfully used for excision of buccal space tumors and how this technique allows reconstruction of the contour defect associated with tumor extirpation by utilization of the superficial musculoaponeurotic system (SMAS) interposition. PATIENTS AND METHODS: Five cases of buccal space tumors are presented: two accessory lobe of parotid tumors, one parotid duct cyst, one nodular fasciitis of anterior masseter, and one lymphoma. RESULTS: Rhytidectomy approach without a submandibular limb incision afforded adequate exposure to the tumors with excellent cosmetic results. Furthermore, SMAS interposition, which was allowed through this technique, ameliorated the contour defect created. CONCLUSION: Rhytidectomy approach with SMAS interposition is effective for management of buccal space tumors. PMID- 9950115 TI - Nasopharyngeal mucosa-associated lymphoid tissue lymphoma in patients infected with the human immunodeficiency virus. PMID- 9950116 TI - Middle ear capillary hemangioma in an infant. PMID- 9950117 TI - Aminoglycoside-induced deafness associated with the mitochondrial DNA mutation A1555G. PMID- 9950118 TI - Pneumoparotitis: diagnosis by computed tomography. PMID- 9950119 TI - Laparoscopic splenectomy: evolution and current status. AB - The aim of this review is to assess the indications for, and surgical approach to, laparoscopic splenectomy (LS) and to propose a recommendation for the surgical approach to LS. The reports of LS were reviewed with a detailed analysis of indications, surgical technique, and clinical outcome. Thirty-two articles including a total of 643 patients (549 adults and 94 children) were published between August 1994 and May 1997, with a mean of 20 cases per report. LS is recommended if the spleen has a maximum diameter of 20 cm. Compared to the open procedure, there are fewer perioperative complications, less morbidity, and a shorter hospital stay. The disadvantages of LS are longer operation times and less sensitivity in identifying accessory spleens. LS is not the operation of choice for hypersplenism and traumatic splenic injury. PMID- 9950120 TI - Laparoscopic adrenalectomy for primary aldosteronism: clinical experience in 12 patients. AB - Laparoscopic adrenalectomy has become a viable option for removal of small adrenal neoplasms. We present our initial experience of this operation for primary aldosteronism. In this prospective study, 12 consecutive patients with primary aldosteronism were operated on laparoscopically by one surgeon. Operative time, blood loss, postoperative pain, complications, hospital stay, convalescence time, and outcome were analyzed. Five right-sided and seven left-sided adrenalectomies were performed in six female and six male patients with a mean age of 51 years. The mean operative time was 126 minutes. All procedures were successfully carried out laparoscopically. No major complications occurred. All patients turned normokalemic and the medication for hypertension could be stopped or diminished in all cases. The mean hospital stay was 3.4 days, and the mean sick leave was 13 days. Laparoscopic adrenalectomy seems to be a safe and effective treatment for primary aldosteronism and should be considered the operation of choice. PMID- 9950121 TI - Stoppa-type laparoscopic repair of complex groin defects. AB - With the laparoscopic approach, bilateral and complex groin defects can be corrected simultaneously by applying a preperitoneal mesh that covers the entire posterior wall of the groin, using a technique similar to the one described by Stoppa. We present our series of hernias repaired by the transabdominal preperitoneal laparoscopic approach with the Stoppa-type technique. The report consists of 78 cases of bilateral defects, of which 60% were indirect bilateral hernias, 23% direct bilateral, and 17% combined defects; 28.5% were recurrent hernias. Only minor complications were observed (hematomas and urinary retention) in some patients, but all resolved spontaneously. Three recurrences (0.7%) have been seen to this date. This method is recommended as the method of choice for complex groin defects. PMID- 9950122 TI - Meta-analysis of randomized controlled trials comparing laparoscopic and open appendectomy. AB - We performed a meta-analysis to determine whether laparoscopic or open appendectomy gives better outcomes for patients with suspected acute appendicitis. Studies were selected from the MEDLINE database, personal files, and meeting abstracts. Eleven of 21 randomized controlled trials were included in the meta-analysis. Pooled effect size estimates were calculated using a random effects model. Laparoscopic appendectomy reduced time to full functioning by 5.48 days (95% confidence interval [CI] 3.70 to 7.26; p < 0.001), improved postoperative pain at 24 hours measured by a visual analog scale from 0 to 10 by 1.19 points (95% CI -2.14 to -0.24 points; p=0.014), and decreased the absolute risk for wound infection by 3.2% (95% CI -5.6% to -0. 8%; p=0.009). Operating time was increased by 17.12 min (95% CI 14.19 to 20.03; p < 0.0001). There was no difference between the two surgeries for length of hospital stay, readmission rate, and intra-abdominal abscess formation. Laparoscopic appendectomy improves patient outcomes. PMID- 9950124 TI - A disposable sealing device (Dispo-sand) for conversion between pneumoperitoneum and minilaparotomy. AB - During laparoscopic procedures, minilaparotomy is a safe technique for removal of large specimens and for the performance of complicated procedures. However, it is time consuming and troublesome to close the minilaparotomy to recreate the pneumoperitoneum. We describe a new device (Dispo-sand) that enables instant conversion between pneumoperitoneum and minilaparotomy. PMID- 9950123 TI - Does laparoscopy reduce the incidence of unnecessary appendicectomies? AB - The aim of this study was to evaluate the impact of laparoscopic appendicectomy on the incidence of histologically normal appendices. Between 1987 and 1997, 1,220 patients (average age 23.5 years [17-73]; 841 women [69%]) had appendicectomy due to the presence of at least one of the following three criteria: right iliac fossa guarding, fever >38 degrees C, and leukocytosis >10,000. Patients were divided into two groups: one group of 930 patients were operated on using the classic Mac Burney approach and the other group of 355 patients underwent laparoscopic exploration, with an appendicectomy performed if macroscopic abnormalities were observed (290 cases). In all cases, the appendices were examined blind and classified as normal or pathologic, with the latter divided with respect to the nature and severity of the lesions. In the Mac Burney group, the incidence of histologically normal appendices was 25.1%. In the laparoscopic group, the incidence was only 8.2% (p=0.015). The types of pathologic appendices were identical between the two groups. In 65 cases (18.3%), a macroscopically normal appendix was left in place. In 56 cases the symptoms were due to another identified cause, however, in 10 cases no cause was found. All patients were followed-up for an average of 3 years. One patient (1.8%) had a second operation (an appendicectomy), which revealed minor histologic lesions. The problem is the inability of the operator to differentiate between a healthy and a pathologic appendix on laparoscopy. The risk of false-positives and false negatives is approximately 10%. Diagnostic difficulties usually occur in the initial phase of the disease with acute mucosal involvement in a morphologically normal appendix. At this stage the outcome cannot be predicted, although appropriate antibiotic treatment can be effective. This study shows that laparoscopy significantly reduces the number of histologically normal appendices as compared to a conventional Mac Burney operation. This can only be achieved by not removing macroscopically normal appendices, a small proportion of which (5 10%) could be cases of early appendicitis with only mucosal involvement. In the absence of other causes of the symptoms, a 3-day course of antibiotics can be tried to treat possible mucosal lesions. This approach reduces costs without having adverse consequences on the outcome. PMID- 9950125 TI - Experimental laparoscopic aortobifemoral bypass with end-to-side aortic anastomosis. AB - The goal of this animal experiment was to demonstrate the feasibility of laparoscopic end-to-side aortic anastomosis, which is mandatory in certain cases presenting with aortoiliac occlusive disease. Six piglets were submitted to laparoscopic approach of the aortoiliac vessels using the "apron" technique. After clamping the infrarenal aorta with a laparoscopic Satinsky clamp, a 3-cm end-to-side laparoscopic aortic anastomosis was constructed. Mean operative and dissection times were 198 (170-240) and 92 (75-105) min, respectively, with a mean blood loss of 86 (50-120) mL. Mean preoperative and postoperative hematocrits were 38 (3448) and 38 (34-46). Aortic cross-clamp and anastomotic times were 51 (40-65) and 44 (35-60) min, respectively. No extra sutures were needed to secure the anastomoses. At autopsy, all the anastomoses were patent without stenoses. Results indicate the feasibility of laparoscopic aortobifemoral bypass with an end-to-side aortic anastomosis. PMID- 9950126 TI - Thoracoscopic surgery in a general surgical service. AB - Following the great success and wide acceptance of laparoscopic surgery, the mini invasive approach has been adopted for use in thoracic surgery. Thoracoscopic surgery is gaining acceptability as the procedure of choice for the treatment of recurrent pneumothorax and bullous lung disease, peripheral benign and malignant lesions, diffuse pulmonary infiltrates, mediastinal and pleural lesions, esophageal surgery, and major pulmonary resections for primary lung tumors. We present the 4-year experience of a general surgery service that extended the use of its advanced laparoscopic skills to the performance of thoracoscopic surgery in 80 patients. Using thoracoscopy, we performed biopsy or excision of pulmonary lesions (23 patients), spontaneous pneumothorax (14 patients), thoracic sympathectomy (41 patients), and Heller's esophagomyotomy and pericardiotomy (1 patient each). The results are excellent, and we believe the procedures presented in this series, and similar ones, can be accomplished safely and successfully by well-trained laparoscopic surgeons. PMID- 9950127 TI - Laparoscopy for chronic abdominal pain. AB - The purpose of this study was to evaluate the usefulness of exploratory laparoscopy in patients with chronic abdominal pain. Forty-six patients underwent diagnostic laparoscopy for abdominal pain of unknown origin during 1992-1996. The average duration of the symptoms was 3.5 years. Patients with known malignancy were excluded. Seventy-two percent of the patients had undergone previous abdominal or groin surgery. An organic disease was found in 68% of the laparoscopies. Adhesions were found in 29 patients, inguinal hernia in 2 patients, and abnormal mesenteric lymph nodes in 1 patient. Adhesiolysis was carried out in 24 patients. Eighty-nine percent of patients could be contacted for follow-up. Mean follow-up time was 19 months. Seventy-seven percent of patients who had undergone adhesiolysis considered the result good or beneficial. Sixty percent of all patients reported a beneficial outcome after laparoscopy. No major complications were noted. This retrospective study suggests that laparoscopy is a safe and useful procedure in the diagnosis and treatment of chronic abdominal pain. PMID- 9950128 TI - The intravenous catheter at McBurney's point. AB - The manipulation of the inflamed appendix during laparoscopic surgery and avoiding its disintegration or leakage can be challenging even to experts. A suture loop form through an intravenous catheter may offer the least traumatic handling of the appendix, and it serves the extra benefit of leaving no scar. Furthermore, multiple loops can be formed conveniently and economically by a single long suture material. It can also ensure snaring at the very base of the appendix. We attempted this technique in 15 patients with 14 successful operations; there was great patient satisfaction and there were no surgical complications. Difficulty was encountered only when the surgeon tried to loop the buried appendix tip that cannot be delivered by one-hand manipulation. PMID- 9950129 TI - Laparoscopic gastrectomy in the porcine model: our initial experience with a new hand-assist device. AB - Many advanced laparoscopic cases remain technically difficult and are less widely accepted. To a great extent, advanced laparoscopic surgery is handicapped by the loss of a surgeon's tactile sense. The concept of introducing the surgeon's hand as an aid to minimally invasive surgery has been described. We report a new hand assist device designed to allow the introduction of the surgeon's hand, wrist, and forearm through a small incision in the abdomen to assist laparoscopic surgery with pneumoperitoneum. Important factors in the hand-assist design are ease of use, reliable maintenance of pneumoperitoneum, and minimal hand/arm fatigue, which were met with this device. PMID- 9950130 TI - Laparoscopic surgery assisted by a transvaginal approach. AB - We used laparoscopic surgery assisted by a transvaginal approach for gastrointestinal diseases. In the first case, a huge submucosal tumor enucleated laparoscopically from the minor curvature of the stomach was extracted through the vagina. In the second case, partial resection of the rectum to treat rectal endometriosis was performed laparoscopically with the assistance of manual handling inserted transvaginally. Although it can be applied only to female patients, especially to multipara, the vagina as an access point to the abdominal cavity can be widely used for various purposes in laparoscopic surgery. PMID- 9950131 TI - Laparoscopic Nissen fundoplication complicated by late gastroesophageal herniation and intrathoracic perforation: a case report with review of the literature. AB - We report the case of a 38-year-old man who, 2 weeks after a laparoscopic Nissen fundoplication, was referred to our Unit because of acute wrap herniation and intrathoracic gastric perforation. Although both of these complications have already been described, this is the first case in which they have occurred simultaneously and not as an immediate consequence of the operation. Intraoperative findings suggested that diaphragmatic crura had not been reapproximated and that the gastric wrap had not been fixed to them. This observation and the fact that immediately after hospital discharge the patient had sustained intense physical efforts can explain acute wrap herniation. Placement of full-thickness sutures may account for gastric perforation. These pathogenetic determinants and their preventive measures are discussed in the light of a review of the literature. PMID- 9950132 TI - Enterocutaneous fistula as a postoperative complication of laparoscopic inguinal hernia repair. AB - Trocar injuries to the small bowel during laparoscopic hernia repair are a rare complication, the most common complications being postoperative neuralgias, scrotal swelling, scrotal ecchymosis, and hematoma. A 15-year-old boy was admitted 5 days status-post transabdominal laparoscopic inguinal hernia repair of a symptomatic right pantaloon hernia, with signs and symptoms of a retrocecal abscess. Despite laparotic intervention and appendectomy, the next 2 years passed with almost daily, purulent, right lower quadrant wound drainage, in an otherwise asymptomatic patient. Superficial wound exploration and sinogram in 1996 revealed a sinus tract in direct communication with the small bowel. Elective laparotomy in December 1997 involved a successful resection of a 2.5-cm fistula with involved mesh, and the communicating small bowel through a midline incision, followed by a primary closure of the small-bowel opening. The patient has recovered without complications. PMID- 9950133 TI - Right-sided colonic diverticulitis mimicking acute cholecystitis in pregnancy: case report and laparoscopic treatment. AB - Right-sided colonic diverticulitis is an uncommon disorder that most frequently mimics appendicitis. During pregnancy, displacement of the diseased cecum and ascending colon into the right upper quadrant may result in symptomatology that mimics cholecystitis. A 37-year-old white woman with a history of previous benign incidental appendectomy presented at 20 weeks' gestation with right upper abdominal pain and nausea for 2 days. Significant findings included local rebound tenderness and palpable fullness over the gallbladder, leukocytosis, and low grade fever, but otherwise unremarkable routine serum laboratory test results and sonographic evidence of biliary tract disease. Cholescintigraphy was rejected by the patient. Persistence of symptoms for 3 hospital days despite administration of broad-spectrum parenteral antibiotics prompted surgical intervention. Laparoscopy demonstrated a normal-appearing gall-bladder and an acutely infected, solitary diverticulum of the midascending colon with adhesions to the omentum and to the parietal peritoneum near the gallbladder. Adhesiolysis, omental biopsy, and peritoneal drainage were performed endoscopically. The patient recovered uneventfully and delivered vaginally at term without fetal or maternal complications. Right-sided colonic diverticulitis may present during pregnancy and may mimic symptoms of acute cholecystitis. Laparoscopic treatment of a solitary, acutely infected colonic diverticulum is feasible in this setting. PMID- 9950134 TI - Laparoscopic port site metastasis of an undetected primary tumor. AB - A 50-year-old woman presented with an adenocarcinoma at a port site of a previous laparoscopic cholecystectomy. A thorough investigation and exploratory laparotomy with excision of the tumor failed to detect its origin. PMID- 9950135 TI - VATS-stepwise resection of a giant bulla in an oxygen-dependent patient. AB - We report a case of a giant bulla in a 16-year-old boy who was oxygen and wheelchair dependent. He had been diagnosed with Marfan's syndrome and had severe kyphoscoliosis. The giant bulla occupying his entire left thoracic cavity compressed the contralateral lung. Until referral to our hospital, a bullectomy had been deferred during the preceding 5 years because of his poor pulmonary function and severe chest wall deformity. The patient was considered a candidate for thoracoscopic bullectomy. A stepwise resection technique was used. First, the bulla should be emptied by aspiration or wall perforation. Second, the redundant wall of the bulla should be resected by a looped ligation without opening the cavity. Third, a stapled resection of the downsized bulla should be performed. After a successful bullectomy, his subjective symptoms and pulmonary function improved. The reduction of the bulla makes bullectomy easily and decreases the number of staplers, and reduces operating time compared with opening the bulla and suturing it. Therefore, when treating a giant bulla, we recommend a stepwise resection technique. PMID- 9950136 TI - Laparoscopic treatment of duodenal diverticulum. AB - A patient with a history of intermittent and intense pain in the upper abdomen secondary to an ulcer of a duodenal diverticulum underwent laparoscopic treatment. The diverticulum measured 2.5 cm in diameter and it was located on the lateral wall of the second portion of the duodenum. The diverticulum was inverted and the duodenal muscular defect was closed with interrupted sutures. Ambulation and a clear liquid diet was started on the same day as the operation, and the patient was discharged on the first postoperative day. PMID- 9950138 TI - Argon beam coagulation in the treatment of spontaneous pneumothorax. PMID- 9950137 TI - Endo-organ and laparoscopic management of gastric leiomyomas. AB - Various techniques have been reported for the laparoscopic treatment of benign gastric lesions, depending on the site of the lesion. Recently, a new technique of endo-organ gastric surgery has been developed that is particular useful for the treatment of lesions on the posterior gastric wall. We report on two patients with submucosal gastric tumors. A 79-year-old man was found to have a submucosal tumor near the esophagogastric junction in the posterior wall of the stomach. Endosonography suggested that the tumor was a gastric leiomyoma. Under endoscopic guidance, three ports were inserted into the stomach and the tumor could be successfully enucleated. A 78-year-old woman was found to have a 2 x 1-cm submucosal tumor at the anterior wall of the antrum. The tumor was successfully removed by laparoscopic gastrotomy and resection. The various laparoscopic techniques for the treatment of gastric lesions are discussed. PMID- 9950139 TI - Placental biogenic amine transporters: in vivo function, regulation and pathobiological significance. AB - The biogenic amine transporters are part of a large family of plasma membrane transporters. These carriers mediate the re-uptake of neurotransmitters from the synaptic cleft and plasma compartments. Re-uptake process is inhibited by drugs like cocaine, fluoxetine and tricyclic antidepressants. There are specific transporters for norepinephrine, epinephrine, dopamine and serotonin. The placenta expresses the norepinephrine and serotonin transporters, which is unusual as they are otherwise expressed predominantly in neuronal tissue. Fetal catecholamine clearance rate is higher than under any other physiological conditions and is mediated in large measure by the placental transporters. The high intrauterine catecholamine secretion and clearance rates are part of the unique fetal neuroendocrine milieu. They condition the fetus to a high capacity for catecholamine secretion in the early postnatal period when elevated sympathoadrenal system activity is vital for postnatal survival. Because of the prominent catecholamine clearance rate, the fetus is vulnerable to the adverse effects of re-uptake inhibitors. Understanding the mechanisms of expression and regulation of placental biogenic amine transporters is important to the pathobiology of fetal conditions associated with elevated catecholamine levels or intrauterine exposure to uptake inhibitors like cocaine. PMID- 9950141 TI - Secretory type II PLA2 immunoreactivity and PLA2 enzymatic activity in human gestational tissues before, during and after spontaneous-onset labour at term. AB - Arachidonic acid mobilization by phospholipase A2 (PLA2) and subsequent prostaglandin synthesis is thought to be a pivotal event in the onset and/or maintenance of human labour. The purpose of this study was to quantify secretory PLA2 (sPLA2) and non-secretory PLA2 enzymatic activity and type II sPLA2 immunoreactivity in human gestational tissues before, during and after labour of spontaneous onset. Placental tissue and fetal membranes were collected from women before, during and after spontaneous-onset labour at term and stored at - 80 degrees C. PLA2 activity in supernatants was quantified by radiolabelled substrate assay (14C-phosphatidylethanolamine) with and without 12.5 mm dithiothreitol (DTT) to separate enzymatic activity contributed by secretory and non-secretory PLA2 components. Immunoreactive type II PLA2 in supernatants was determined by a monoclonal, non-competitive sandwich ELISA. Total PLA2 enzymatic activity in amnion, choriodecidua and placenta was not significantly different before, during and after labour (n=18-20). Likewise, non-secretory enzymatic activity was not significantly different before (n=9), during (n=10) and after labour (n=9) in any of the three types of gestational tissue examined. Although immunoreactive type II PLA2 was significantly higher in the placenta (P<0.01) compared to amnion and choriodecidua, there was no significant difference in immunoreactive type II PLA2 within each tissue group according to labour status (n=18-20). Overall, no change in PLA2 secretory or non-secretory enzymatic activity or immunoreactive type II PLA2 could be detected throughout the peripartum period. PMID- 9950140 TI - Interconversion of cortisol and cortisone by 11beta-hydroxysteroid dehydrogenases type 1 and 2 in the perfused human placenta. AB - The human placenta contains two types of 11beta-hydroxysteroid dehydrogenase (11beta-HSD). The exclusive oxidase 11beta-HSD2 has been suggested to protect the fetus from high levels of maternal glucocorticoids by converting cortisol to inactive cortisone. Perfused term human placenta was used to examine the activity of the oxoreductase 11beta-HSD1 and to determine the regulation of cortisol effects on placental vascular tone and corticotropin-releasing hormone (CRH) output by 11beta-HSD. Radioimmunoassay showed that there was substantial cortisol (295+/-57 nM) detected in the fetal vein upon perfusion of cortisol (2 microM; perfusion rate, 12 ml/min) into the maternal intervillous space. Output of cortisol increased to 559+/-22 nM on the fetal side (P<0.05) with concurrent perfusion of carbenoxolone (CBX; 1 microM), a non-specific 11beta-HSD inhibitor. Cortisol formation increased in a dose-dependent manner with infusion of cortisone (0.1-2 microM) into the maternal intervillous space reaching 15 and 23 nM in fetal and maternal venous outflows respectively at 2 microM cortisone perfusion. There was no significant effect of cortisol either alone or in combination with CBX on the fetal arterial perfusion pressure, but cortisol perfusion increased CRH output into the fetal vein. It is concluded that activities of both 11beta-HSD1 and -2 are demonstrable in perfused human placenta in vitro, and these enzymes affect transplacental glucocorticoid transfer. These activities may provide a precise mechanism to control the passage of maternal glucocorticoids to the fetal circulation, and to regulate glucocorticoid effects within the placenta. PMID- 9950142 TI - Distribution of interleukin-1 receptors in term human fetal membranes and decidua. AB - Interleukin-1 (IL-1) is a dimorphic cytokine that acts on target cells through high-affinity receptors, type I and type II. It has been implicated in the onset of term and preterm labour with associated intrauterine infection. To define better the potential action of this cytokine in the human fetal membranes and decidua, the objective of this study was to define the type(s) of IL-1 receptors present in the tissues at term, examine the tissue and cellular distribution of the receptor(s) and determine if there were any changes in their expression or distribution with the onset of labour. Tissues were obtained following elective caesarean section (n=12) or normal labour delivery (n=11). Paraffin embedded and frozen sections were examined by immunohistochemistry and in situ hybridization for evidence of the type I and type II receptors and their corresponding mRNAs. In all tissues studied the type I receptor was localized mainly to the decidua and the type II receptor was localized to the decidua and scattered cells in the amnion-chorion mesenchymal layer. In situ hybridization localized type I receptor mRNAs and type II receptor mRNAs to the decidua. The type I and type II receptor protein in the decidua showed a similar pattern of staining as that found for CD 68, a macrophage marker. The pattern of receptor expression and distribution was unrelated to the mode of delivery. No evidence for the presence of the type I or type II receptor or their mRNAs in the amnion epithelial cells or chorion laeve trophoblast was found. PMID- 9950143 TI - Immunohistochemical localization of vascular endothelial growth factor (VEGF) and its two specific receptors, Flt-1 and KDR, in the porcine placenta and non pregnant uterus. AB - Placental angiogenesis and growth are crucial elements in embryonic and later fetal development. Vascular endothelial growth factor (VEGF) and its specific receptors Flt-1 (VEGFR-1) and KDR (VEGFR-2) compose potent ligand receptor systems involved in angiogenesis and microvascular hyperpermeability. In the present immunohistochemical study, VEGF, Flt-1 and KDR were localized in uterus of cyclic non-pregnant pigs and in the porcine epitheliochorial placenta throughout gestation. Emphasis was placed on early gestational stages, where morphological studies have demonstrated extensive angiogenesis during initial placentation. The results revealed a high correlation in spatiotemporal distribution between the ligand and its receptors and a surprising demonstration of VEGF receptors in several non-endothelial cells. In non-pregnant pigs, VEGF, Flt-1 and KDR exhibited moderate to intense staining in uterine luminal epithelium and smooth muscle cells of the vessel walls. Endothelial cells of arteries and arterioles revealed labelling for Flt-1 and KDR, whereas the uterine glandular epithelium displayed intense KDR immunoreactivity at the late luteal phase. During gestation the uterine luminal epithelium demonstrated weak ligand and receptor immunostaining in the first half of early gestation [< or = 21 days post coitus (p.c.)], whereas later stages (> or = 21 days p.c.) displayed intense immunolabelling. Endothelial cells, smooth muscle cells of the vessel walls and uterine glandular epithelium revealed intense ligand and receptor immunoreactivity throughout gestation. In the fetal part of the placenta, VEGF, Flt-1 and KDR immunostaining displayed moderate to intense reactivity in the trophoblast throughout gestation, except during the second half of early gestation (days 21-30 p.c.). Fetal vessel walls were also immunopositive for VEGF, Flt-1 and KDR. Taken together, the results imply that the VEGF, Flt-1 and KDR ligand receptor system participate in the regulations of porcine placentation and that it in addition to its angiogenic properties also may influence the cellular differentiation and transport capabilities in uterine luminal as well as glandular epithelium and the trophoblast. PMID- 9950144 TI - A lectin binding analysis of glycosylation patterns during development of the equine placenta. AB - The glycosylation of the equine interhaemal barrier and areola was studied throughout the period of gestation. Placentae of 35, 37, 50, 119, 152, 200, 280 and 300 days gestation were investigated, using semithin plastic embedded sections and a panel of 15 biotinylated lectins with an avidin-peroxidase revealing system. Glycosylation of the trophoblast and maternal epithelium showed the most change during the first 50 days of gestation, being associated with the initial stages of adhesion and attachment. In the trophoblast, non-bisected tri/tetraantennary complex N-glycan was only evident after day 37 and terminal N acetyl galactosamine, alpha2,3- and alpha2,6-linked sialic acids disappeared at the same time. The areolar trophoblast exhibited some differences from microcotyledonary areas, especially with respect to 2-deoxy, 2-acetamido alpha galactose and tri/tetraantennary, non-bisected complex N-glycan, suggesting that the differences in function between microcotyledonary and areolar trophoblast are reflected at both the morphological and the biochemical level. Granules of the maternal uterine epithelium bound many lectins, particularly those with specificity for bisected and non-bisected bi/triantennary N-linked glycan, 2 deoxy, 2-acetamido alpha-galactosyl, beta-galactosyl and some fucosylated termini. Binding to sialic acids in alpha2,3- and alpha2,6-linkage was sparse. Maternal and fetal capillaries showed little change in glycan expression over the period studied, being rich in bisected and non-bisected bi/triantennary N-linked glycan and sialic acids, with some terminal N-acetyl galactosamine and no detectable terminal fucosyl residues. PMID- 9950145 TI - Diffusive transfer of water and glucose across the chorionic plate of the isolated human term placenta. AB - This study investigated systematically the diffusive transfer of water and glucose across the chorionic plate of the human placenta. Isolated sections of human term placentae were perfused at the fetal side (open loop) with modified Ringer's solution (n=31). An artificial amniotic compartment was created on top of the chorionic plate. 3H- and 14C-labelled tracer pairs were added (donor side) to the fetal perfusion fluid or to the 'amniotic' fluid. Transfer fractions (TF, ratio of acceptor side to donor side radioactivity) were calculated as percentages. TF of water and L-glucose from perfusion fluid into the 'amniotic' fluid were 3.9+/-0.5 per cent (mean+/-SEM) and 1.2+/-0.3 per cent after 60 min and significantly different (n=6). In each sample of the following experiments the transfer fraction of the D-hexose was larger than that of the L-isomer. At 60 min, the TF were 1.6+/-0.2 and 1.1+/-0.2 per cent (D-glucose/L-glucose; fetal to amniotic compartment, n=8), from amniotic compartment to fetal perfusate 0.6+/ 0.1 and 0.4+/-0.1 per cent (D-glucose/L-glucose, n=11), and 0.8+/-0.1 and 0.6+/ 0.1 per cent (3-O-methyl-D-glucose/L-glucose, n=6). The difference between the latter TF lost its significance after cytochalasin B (0.1-0.2 mmol/l) had been added to the amniotic compartment. It is concluded that a limited diffusive pathway across the chorionic plate of the human placenta exists and that the transfer of D-glucose depends in part on facilitated diffusion. PMID- 9950146 TI - Uptake of reverse T3 in the human choriocarcinoma cell line, JAr. AB - The uptake and efflux of reverse triiodothyronine (rT3) in JAr cells were investigated. Uptake of 125I-rT3 was time dependent and reversible with a saturable component of around 70 per cent of total uptake after 30 min of incubation. Efflux was not saturable. Kinetic analysis of the initial specific uptake rates revealed an uptake process with a Michaelis constant of 3.04+/-0.53 microM (mean+/-SEM, n=15) and a corresponding maximum velocity of 9.65+/-2.49 pmol/min/mg protein (n=15). Uptake of rT3 was stereospecific, but not specific for rT3, as unlabelled L stereoisomers of thyroid hormone analogues were more effective as inhibitors of 125I-rT3 uptake than rT3. Unlabelled T3 and thyroxine (T4) (10 microM) reduced cellular uptake of 125I-rT3 by around 82 and 74 per cent, respectively. The calculated inhibition constants Ki were 1.23+/-0.29 microM (n=4) and 0.66+/-0.19 microM (n=4) for T3 and T4, respectively. Similarly, rT3 reduced cellular uptake of 125I-T3 and 125I-T4 by 34 and 23 per cent, respectively. The calculated inhibition constants Ki were 1.75+/-0.55 microM (n=8) and 1.08+/-0.36 microM (n=8) for the inhibition of 125I-T3 and 125I-T4 uptake, respectively. Reverse T3 inhibited efflux of 125I-T3 from the cells by around 20 per cent, but did not inhibit efflux of 125I-T4. These results suggest that uptake of rT3 in JAr cells may occur via a single, saturable membrane carrier, which also interacts with T3 and T4, while efflux of rT3 may occur by passive diffusion. PMID- 9950147 TI - Purification and characterization of a complex from placental syncytiotrophoblast microvillous membranes which inhibits the proliferation of human umbilical vein endothelial cells. AB - The signs of pre-eclampsia are thought to arise from maternal endothelial dysfunction caused by circulating factors of placental origin. Syncytiotrophoblast microvillous membranes (STBM) cause endothelial disruption and inhibit proliferation in vitro. Significantly increased amounts of STBM can be detected in blood from pre-eclamptic women and could contribute to endothelial dysfunction in vivo. This study purified a complex from STBM which inhibits the proliferation of cultured human endothelial cells. Integral membrane proteins were solubilized with sucrose monolaurate. Anion exchange chromatography yielded two peaks of anti-proliferative activity. Only the second peak was specific to STBM and was subjected to further separation by Sephacryl S-200 gel filtration chromatography (GFC). A single peak of specific activity eluted close to the void volume, at a position unaltered by added denaturing agents, guanidium chloride or urea. On Sephacryl S-300 GFC, two peaks were obtained of 410 and 820 kDa, with similar anti-proliferative activity and protein components (by SDS-polyacrylamide gel electrophoresis). The major protein bands were as integrins alpha5 and alpha v, dipeptidyl peptidase IV, alpha-actinin, transferrin, transferrin receptor, placental alkaline phosphatase and monoamine oxidase A. PMID- 9950148 TI - Glucose-6-phosphatase is present in normal and pre-eclamptic placental trophoblasts: ultrastructural enzyme-histochemical evidence. AB - The purpose of the present study was to localize glucose-6-phosphatase (G6Pase) activity in the human placenta at various gestational stages and to compare them to pre-eclamptic placenta activity. Ultrastructural enzyme-histochemical analysis of G6Pase was performed using cerium and lead as capturing agents. Precipitates indicative of G6Pase activity were observed in the endoplasmic reticulum and the nuclear envelope of the syncytiotrophoblasts in near-term placenta obtained from women with normal pregnancies. In placenta taken from women with severe pre eclampsia, the localization pattern, enzyme activity intensity, and morphology of the endoplasmic reticulum did not differ from normal pregnancies. Stringent control experiments were performed also to ensure specific detection of G6Pase activity. The results indicate that cytochemically detectable G6Pase is present in the human placenta. This enzyme may play significant roles in carbohydrate metabolism in the human placenta. PMID- 9950149 TI - Increased placental iron regulatory protein-1 expression in diabetic pregnancies complicated by fetal iron deficiency. AB - Placental transferrin receptor (TfR) protein expression is increased in diabetic pregnancies that are complicated by low fetal iron stores, suggesting regulation of placental iron transport by fetoplacental iron status. In cell culture, iron homeostasis is regulated by coordinate stabilization of TfR mRNA and translation inactivation of ferritin mRNA by iron regulatory proteins (IRP-1 and -2) which bind to iron-responsive elements (IREs) on the respective mRNAs. Concentrations of IRP-1, IRP-2 and TfR mRNA were measured in 10 placentae obtained from diabetic and non-diabetic human pregnancies with a wide range of fetoplacental iron status. IRP-1 activity was present in human placenta and correlated closely with TfR mRNA concentration (r=0.82; P=0.007). IRP-2 activity and protein were not detected. In a second experiment, placentae were collected from 12 diabetic pregnancies, six with low fetal cord serum ferritin and placental non-heme iron concentrations, and six with normal iron status. IRP-1 activity and TfR Bmax for diferric transferrin were greater in the iron-deficient group (P<0.05). IRP-1 activity correlated inversely with cord serum ferritin (r=0.75; P<0.01) and placental non-heme iron (r=0.61; P=0.05) concentration. Placental IRP-1 activity is directly related to TfR mRNA concentration and is more highly expressed in iron-deficient placentae. The study provides direct in vivo evidence for IRP regulation of TfR expression in the human placenta. PMID- 9950150 TI - Localization of thioredoxin reductase and thioredoxin in normal human placenta and their protective effect against oxidative stress. AB - Recent studies have indicated that oxidative stress is involved in the pathogenesis of pre-eclampsia. Oxidative stress damages systemic tissues, and placental damage may result in intrauterine growth retardation and fetal distress. Thus, this study attempted to elucidate the placental localization of thioredoxin and thioredoxin reductase, substances that may reduce oxidative stress. Furthermore, it studied the defence mechanism of the thioredoxin thioredoxin reductase system against oxidative stress in mitochondria of normal human placenta where reactive oxygen species are primarily produced. The examination of thioredoxin reductase activity in subcellular fractions of human placenta indicated that thioredoxin reductase was located not only in cytoplasm, but also in mitochondria. The existence of thioredoxin and thioredoxin reductase in human placenta was confirmed immunologically using antibodies raised against thioredoxin and thioredoxin reductase. Thioredoxin and thioredoxin reductase were localized histochemically in cytotrophoblasts, decidua, and stromal cells in the stem villi. The addition of exogenous thioredoxin and thioredoxin reductase to fumarase in mitochondria of human placenta displayed a protective effect against oxidative stress. In conclusion, this study confirmed the intracellular localization and the tissue distribution of thioredoxin and thioredoxin reductase in human placenta. Moreover, the complete thioredoxin-thioredoxin reductase system in human placenta may protect the placenta from damage caused by oxidative stress. PMID- 9950151 TI - Globoside expression within the human placenta. AB - This report demonstrates the presence of the neutral glycosphingolipid, globoside, on the villous trophoblast layer of human placenta. Immunoreactivity for globoside which is the receptor used by human parvovirus B19 was strongest in villous trophoblast cells of first trimester placentae, with diminished reactivity in second trimester placentae, and a near lack of staining for the antigen in those of third trimester. This relative reduction in globoside specific immunoreactivity in placentae of increasing gestational ages was confirmed using thin-layer chromatographic analyses of extracted neutral glycolipids from the syncytiotrophoblast layer and cytotrophoblast cells of first and third trimester placental villi. The presence of globoside on the protective trophoblast layer of the villi provides a potential pathway whereby B19 may be transmitted from an infected mother to the fetus. The virus once across the placental barrier, may gain access to its erythroid precursor target cells within fetal villus capillaries. The observed change found in globoside immunoreactivity correlates well with the observation that fetal outcome is worse when maternal infection occurs during first or second trimester as compared to an infection occurring near term. The reason for this observed difference in fetal outcome may be due not only to the presence of more target cells potentially to infect during the first and second trimesters, but also to the greater number of viral receptors present on the villous trophoblast layer. PMID- 9950152 TI - Expression of endogenous retrovirus ERV-3 induces differentiation in BeWo, a choriocarcinoma model of human placental trophoblast. AB - Differentiation-related expression of endogenous retrovirus ERV-3 env in the normal human placental syncytiotrophoblast suggests a role in placental development. The choriocarcinoma cell line BeWo, a model of trophoblast differentiation, is maintained in an undifferentiated state and undergoes differentiation upon the addition of forskolin. The expression of ERV-3 env mRNA increased after 48 h forskolin treatment, concurrently with increased intercellular fusion and production of human chorionic gonadotropin (beta-hCG) mRNA, a hormonal differentiation marker for trophoblast. Over expression of ERV-3 env induced differentiation of BeWo characterized by decreased cell growth, differentiation-related morphologic changes, and induction of beta-hCG mRNA. These results support the first known role for the expression of an endogenous retrovirus in trophoblast differentiation. PMID- 9950154 TI - Steam heat with an EDTA buffer and protease digestion optimizes immunohistochemical expression of basal cell-specific antikeratin 34betaE12 to discriminate cancer in prostatic epithelium. AB - In select cases of prostatic carcinoma, antikeratin 34betaE12 immunohistochemical analysis is diagnostically useful for specific labeling of basal cells. This antibody, however, is prone to variability in staining, and the optimal conditions were not, to our knowledge, previously defined. We combined steam heat with EDTA buffer (steam-EDTA) and protease digestion (steam-EDTA + protease) to optimize epitope retrieval of antikeratin 34betaE12 in 42 cases of prostatic cancer. Results were judged by the percentage of cells staining and by staining intensity. In benign epithelium, steam-EDTA + protease significantly increased the percentage of immunoreactive cells (from 74 to 93%) and the intensity of staining (from 2.1 to 3.0 on a scale of 0-3+) by comparison with protease alone (all P<.001). In high-grade prostatic intraepithelial neoplasia, the percentage of cells staining increased from 55 to 73% and intensity increased from 1.7 to 2.8 (both P<.001). Steam-EDTA + protease also minimized variability in results between cases, with essentially no background stromal staining. Cancer was negative in all of our cases by both methods. We conclude that steam-EDTA + protease significantly enhances basal cell immunoreactivity compared with protease treatment alone in noncancerous prostatic epithelium. This helps to prevent misinterpretation of histologic mimics of cancer, such as atrophic acini and high-grade prostatic intraepithelial neoplasia, that result from false negative staining. PMID- 9950153 TI - EGF promotes development of a differentiated trophoblast phenotype having c-myc and junB proto-oncogene activation. AB - Human placental cytotrophoblast cells differentiate by a process of fusion into a syncytium. This process is stimulated by EGF but also occurs spontaneously at a slower rate in cultured cytotrophoblast cells. To determine nuclear proto oncogene changes mediating these events, c-myc, c-fos, c-jun and junB were measured in spontaneously differentiating cells and in cells exposed to EGF. c myc showed a transient rise in expression at 4-8 h with augmented expression by EGF, occurring even in the absence of serum or attachment. c-myc and c-jun declined during culture, but c-fos and particularly junB showed increased expression by day 3 with marked responses to EGF stimulation. Syncytia induced to form by EGF exposure for 48 h demonstrated marked junB expression after rechallenge with 40 min EGF exposure, but negligible responses of c-fos and c jun. c-myc showed increased expression after 6 h EGF exposure throughout the culture period and in syncytia. The results indicate EGF promotes a syncytial phenotype characterized by c-fos and junB expression during syncytial formation. EGF continues to elicit junB and c-myc responsiveness in more mature syncytium, indicative of continued EGF actions which may include acting as a survival factor, as an hCG secretagogue, and as an inducer of continued development of the syncytium. PMID- 9950155 TI - Thyroid transcription factor-1: immunohistochemical evaluation in pulmonary neuroendocrine tumors. AB - Thyroid transcription factor-1 (TTF-1), a nuclear transcription protein selectively expressed in the thyroid, the diencephalon, and respiratory epithelium, is expressed in more than 90% of pulmonary small cell carcinomas (SCLCs) and in almost 75% of pulmonary non-small cell carcinomas (NSCLCs), but it is absent in typical pulmonary carcinoids (TCs). Therefore, it was thought that SCLC and NSCLC might share a common lineage, different from that of TC. TTF-1 expression in atypical pulmonary carcinoids (ACs) and large-cell neuroendocrine carcinomas (LCNECs) was not studied previously. We examined TTF-1 expression in 51 TCs, 9 ACs, 8 LCNECs, and 21 SCLCs with use of formalin-fixed material and heat-induced epitope retrieval. TTF-1 expression was seen in 18 (35%) of 51 TCs, all of the 9 ACs, 6 (75%) of the 8 LCNECs, and 20 (95%) of the 21 SCLCs. These results reinforce earlier findings of the excellent sensitivity of TTF-1 for SCLC, and they show similar sensitivity for AC and LCNEC, but they argue against the hypothesis that SCLC and TC are of different cell lineages. The ubiquity of TTF-1 expression in pulmonary NECs demonstrated in this study also argues against its use in their subclassification. PMID- 9950156 TI - Desmoid tumors of the pleura: a clinicopathologic mimic of localized fibrous tumor. AB - Intrathoracic desmoid tumors of the pleura are unusual tumors that are often clinically and histologically confused with localized fibrous tumor of the pleura or benign neurogenic tumors. We studied four cases of intrathoracic desmoid tumor of the pleura and reviewed the clinical, histopathologic, and immunohistochemical features of the four patients. Two men and two women, ranging in age from 16 to 66 years (mean, 44 yr) comprised the study group. Three patients presented with chest pain and one with shortness of breath. Two patients had a history of associated trauma in the area of the tumor. Three of the lesions were based in the parietal pleura and one in the visceral pleura. Treatment included complete resection (two cases), subtotal resection (one case), and subtotal resection followed by radiation therapy and complete resection (one case). The mean tumor size was 12.5 cm, and all of the tumors exhibited a bosselated, firm, white, cut surface. The histologic features of intrathoracic desmoid tumors were similar to those of desmoid tumors at more conventional sites. Infiltration of the adjacent fat and skeletal muscle was invariably present. The tumor cells were immunoreactive for vimentin, desmin, smooth muscle actin, and muscle-specific actin in three of the four cases and were negative for S-100 protein. Follow-up to date shows stable residual disease at 12 months (one case) and two patients with no evidence of disease at 12 and 96 months, respectively. Intrathoracic desmoid tumors often exhibit clinical and radiographic features similar to localized fibrous tumor of the pleura. They generally have histologic and behavioral characteristics identical to those of desmoid tumors at conventional sites. Like desmoid tumors elsewhere, complete resection with negative margins is vital to prevent local recurrence. Desmoid tumor should be considered in the differential of localized fibrous tumor of the pleura. PMID- 9950157 TI - Clinicopathologic characteristics of replication error-positive gastric carcinoma. AB - Microsatellite instability (MI), an expansion or contraction of microsatellites, is a manifestation of replication errors (RERs) that is recognized as performing an important role in carcinogenesis in a proportion of gastric carcinomas. We analyzed 96 cases of sporadic gastric carcinomas for the occurrence of MI in BAT 26 and other six microsatellite loci. Gastric carcinomas with BAT-26 alteration demonstrated a higher proportion of unstable loci in other examined microsatellites than did gastric carcinomas without BAT-26 alteration. We classified gastric carcinomas with BAT-26 alteration as RER+ and compared the RER status with their clinicopathologic features. Ten (10.4%) of 96 gastric carcinomas showed RERs: 2 (7.7%) of 26 early gastric carcinomas and 8 (11.4%) of 70 advanced gastric carcinomas were RER+. RER+ gastric carcinomas were significantly associated with older age, elevated gross type (Borrmann Type 2 or EGC IIa), expanding growth pattern (Ming's classification), and minimal desmoplasia. Although statistically not significant, RER+ gastric carcinomas showed more frequent intestinal type (Lauren's classification), more antral involvement, and lower lymph node metastasis than did RER- gastric carcinomas. There was no association between RER status and intratumoral lymphocyte infiltration or histologic differentiation. In conclusion, RER+ gastric carcinomas demonstrated distinct clinicopathologic features, and BAT-26 was a useful marker for assessing the RER status of gastric carcinomas. PMID- 9950159 TI - False-negative rates of tumor metastases in the histologic examination of bone marrow. AB - Recent reports have claimed that bone marrow histology is less sensitive for detecting metastatic tumor than are other methods of marrow examination. These reports, however, did not specify methodologic information, such as the number of slides or tissue sections reviewed. To demonstrate the importance of specifying such information, we reviewed archival, tumor-positive marrow biopsy specimens from our laboratory. By means of a statistical model, we calculated the false negative rates that would have occurred had random histologic review entailed fewer than 10 slides. Our model demonstrates a progressive increase in the percentage of false-negative diagnoses with the review of fewer slides, e.g., from 1% with review of nine slides to as high as 24% with review of only two slides. We conclude that the number of histologic slides and tissue sections reviewed should be specified when comparing bone marrow histologic examination with other techniques of marrow assessment. PMID- 9950158 TI - Retroperitoneal leiomyosarcomas unassociated with the gastrointestinal tract: a clinicopathologic analysis of 17 cases. AB - Data are limited on leiomyosarcomas within the abdomen and retroperitoneum, particularly if one discounts those associated with the gastrointestinal (GI) tract. Recently, some authors proposed that certain tumors in this location are more appropriately termed extra-GI stromal tumors, given their histologic resemblance to GI stromal tumors as opposed to conventional soft tissue leiomyosarcomas. We evaluated the clinical and pathologic features of 17 cases of leiomyosarcoma (16 retroperitoneal, one intra-abdominal) and recorded the tumor size, predominant cell type, tumor cellularity, nuclear pleomorphism, extent of tumor cell necrosis, and number of mitotic figures per 10 high power fields (MFs/10HPFs). Cases were only included for study if the excised tumor did not arise from abdominal or pelvic viscera or major blood vessels, if adequate clinical follow-up was available, and if the tumor unequivocally resembled conventional soft tissue leiomyosarcoma, both by light microscopic and immunohistochemical examination. The cohort included 16 women and 1 man, and ages ranged from 44 to 72 years (median, 60 yr). Tumors ranged in size from 6.5 to 29.5 cm (median, 13.5 cm). Fifteen tumors were composed predominantly of spindled cells, one tumor was composed predominantly of epithelioid cells, and one tumor was composed of an admixture of spindled and epithelioid cells. Follow-up intervals ranged from 4 to 169 months (median, 47 mo). Fifteen (88%) of seventeen patients developed an adverse outcome, defined as the development of metastatic disease or death due to tumor. Patients whose tumors had greater than 10 MFs/10HPFs had significantly shorter intervals to either metastasis or death than did those whose tumors had 10 or fewer MFs/10HPFs (8.4 mo vs. 42 mo; P = .003). No other features correlated with time to adverse outcome. In conclusion, the majority of patients with leiomyosarcomas located within the abdomen or retroperitoneum progress to metastatic disease or die from their tumor. The only feature that is significantly associated with a shorter interval to either metastasis or death is more than 10 MFs/10HPFs. PMID- 9950160 TI - Interstitial foam cells and oxidized lipoprotein in human glomerular disease. AB - Foam cells (FCs) have been detected in the cortical interstitium of some patients with glomerular disease. Whether they have a significant role in tubulointerstitial injury and disease progression is uncertain. Renal biopsy specimens from 13 patients with glomerular disease (6 with Alport's syndrome, 5 with focal glomerulosclerosis, 2 with membranoproliferative glomerulonephritis, Type 1) showing interstitial FCs were investigated by histochemical means for neutral lipid (oil red O stain); immunohistochemical means for monocytes/macrophages (CD68), apolipoproteins (Apo) A-I, B, and E, and oxidized low-density lipoprotein (LDL); and by electron microscopic examination. FCs were positive for neutral lipid, CD68, and oxidized lipoprotein but did not stain for Apo B. In four specimens, there was a weak FC reaction for Apo E alone and in one case for both Apo E and Apo A-I. Focal interstitial staining was observed for both Apo B and E but not for Apo A-I. There was focal staining of tubular epithelial cytoplasm for neutral lipid in all of the specimens, for Apo E in five of seven specimens, for oxidized lipoprotein in case, and for Apo A-I in three cases. Electron microscopic analysis showed that the FC contained numerous clear cytoplasmic vacuoles that were not membrane-bound and that were generally associated with increased numbers of collagen fibrils and basement membrane-like extracellular matrix and frequently with aggregates of extracellular lipid-like particles embedded in extracellular matrix. The findings are analogous to those in atherosclerosis and suggest a role for FCs and oxidized lipoprotein in the pathogenesis of interstitial injury in some cases of glomerular disease. PMID- 9950161 TI - Telomerase activity in microdissected human gliomas. AB - Future improvements in the diagnosis and treatment of human gliomas might rely on obtaining more specific information concerning the biologic characteristics of individual tumor cells. Telomerase, a ribonucleoprotein that synthesizes telomeres, has been reported to be expressed in a majority of human tumors, including several subtypes of brain tumor. We hypothesized that a quantitative assay for telomerase activity, combined with selective microdissection of tumor or normal brain cells, might reveal telomerase gain-of-function to be important in the pathogenesis of gliomas and that telomerase levels might have prognostic significance. We used tissue microdissection for selective analysis of tumor cells obtained from eight patients with glioma, one with a meningioma, and one with a primary B-cell lymphoma of the central nervous system. Normal brain tissue microdissected from another patient was used as a control. Telomerase activity was screened by an electrophoretic method and then assayed by a quantitative ELISA method. All of the eight gliomas had positive telomerase activity, as did the lymphoma. The meningioma and normal brain were negative. Quantitative analysis of telomerase activity did not correlate with tumor grade nor predict outcome. Selective tissue microdissection, combined with qualitative and quantitative telomerase assays, permits rapid and reliable detection of telomerase activity in diverse brain tumor tissues. These preliminary findings suggest that telomerase reactivation is a frequent event in glioma tumorigenesis that can be sensitively and specifically detected in gliomas of all histologic grades. Furthermore, specific detection of telomerase reactivation represents another mechanism by which tumor formation and progression might become the target of novel therapeutics. PMID- 9950163 TI - p53 immunoreactivity and single-strand conformational polymorphism analysis often fail to predict p53 mutational status. AB - The intent of this study was to investigate the ability of p53 expression and single-strand conformational polymorphism analysis (SSCP) to predict p53 mutational status in archival, paraffin-embedded tissues of gastric cancer. We evaluated paraffin-embedded tissues from 78 patients with advanced gastric cancer. The mutational status of the p53 gene (exons 5-9) was examined by SSCP analysis and by direct sequencing. These results were compared with p53 expression as assessed by immunohistochemical analysis (IHC). We graded p53 expression on a scale from 0 to 8 on the basis of both the intensity and the number of cells staining. Overall, we detected p53 immunoreactivity in 75.6% of the gastric cases; 19 (32.2%) of these cases scored from 1 to 4, and 40 (67.8%) cases scored from 5 to 8. p53 gene mutations were detected in 18 cases (23.1%) by SSCP and in 28 cases (36%) by direct sequencing. Thus, SSCP failed to detect 38% of the mutations found by sequencing. The majority of missed mutations involved exons 7 and 8. The concordance between IHC and SSCP was 37%, and the concordance between IHC and direct sequencing was 50%. Forty-five percent of cases positive by IHC failed to show mutations in exons 5 through 9. Five percent of cases negative by IHC (4 cases) contained mutations. One had a 1-base pair insertion; one had a mutation that resulted in a stop codon; the third had a mutation in exon 8; and the fourth had a mutation in both exons 5 and 8. Our findings indicate that p53 immunoreactivity correlates with the presence or absence of gene mutations in 50% of advanced gastric cancers when exons 5 through 9 are examined and that IHC cannot be reproducibly used as a marker of mutation in the most commonly mutated exons of the p53 gene. Furthermore, the sensitivity of SSCP for detecting mutations is only 62%. Thus, SSCP analysis cannot be used reliably to screen for p53 mutations. PMID- 9950162 TI - Loss of retinoblastoma protein expression in laryngeal squamous cell carcinoma. AB - Laryngeal carcinomas are among the most curable malignancies, but some of them show poor clinical outcomes with local recurrence or regional neck metastasis. Multiple genetic alterations of oncogenes and tumor suppressor genes are thought to occur in the development some tumors. The frequency, however, and the prognostic significance of these genes or gene products still remain unknown in laryngeal carcinoma. Epidemiologic data suggest that cigarette smoking is closely related to the development of these neoplasms; and human papillomavirus (HPV) infections have also been postulated to play a role in development of laryngeal tumor. The objective of this study was to investigate the presence of retinoblastoma protein (pRb), p53 protein, and HPV infection in laryngeal squamous cell carcinoma, as well as the correlation of these factors with clinicopathologic and carcinogenic factors. Tumors from 79 patients with primary laryngeal squamous cell carcinoma were studied. The expression of pRb was immunohistochemically assessed in 79 such tumors, and the expression of p53 was assessed in 76 tumors. HPV Type 16 expression was estimated by nonisotopic in situ hybridization in 78 cases. Follow-up periods ranged from 15 to 90 months. pRb was detected in 82% of the tumors and p53 in 43%. Lack of staining for pRb was significantly associated with a high-histologic grade (P<.05), high T classification (P<.05), recurrence (P<.05), and a relatively short disease-free interval (P<.01). p53 overexpression was observed frequently in heavy smokers with an average Brinkman index of more than 800, but it was not associated with any of the clinicopathologic factors studied. These findings suggest that tumors exhibiting loss of pRb expression have a more aggressive biologic behavior than do those that express pRb and that loss of pRb expression might predict clinical outcome in patients with primary laryngeal squamous cell carcinoma. PMID- 9950164 TI - Expression of the ets-1 proto-oncogene in human thyroid tumor. AB - The proto-oncogene ets-1 is a transcription factor known to control the expression of a number of genes involved in extracellular matrix remodeling. To elucidate the involvement of ets-1 in human thyroid carcinoma, we examined 68 cases of thyroid carcinoma and 38 cases of benign tumors by immunohistochemical means. ets-1 was not expressed in normal thyroid follicular cells. Among the 69 cases of thyroid carcinoma, 61 (89.7%) showed positive staining for the ets-1 protein. According to histologic classification, 47 (97.9%) of 48 papillary carcinomas, 7 (87.5%) of 8 follicular carcinomas, 3 (60.0%) of 5 medullary carcinomas, and 4 (50.0%) of 8 anaplastic carcinomas showed positive staining of ets-1. Among the benign tumors, staining was positive for ets-1 in 8 (40.0%) of 20 adenomas and 3 (16.7%) of adenomatous goiters. In situ hybridization also confirmed the expression of ets-1 mRNA in thyroid carcinoma. Expression of ets-1 mRNA was seen in three kinds of cultured human thyroid carcinoma cell lines and carcinoma tissue obtained at surgery by reverse transcription-polymerase chain reaction. These findings suggest that ets-1 is deeply involved in thyroid carcinogenesis. PMID- 9950165 TI - Immunohistochemical analysis of the proliferation associated nuclear antigen CENP F in non-Hodgkin's lymphoma. AB - CENP-F is a newly characterized cell cycle-associated nuclear antigen that is expressed in low amounts in G0/G1 cells and that accumulates in the nuclear matrix during S phase with a maximal expression in G2/M cells. CENP-F can be analyzed by flow cytometry and used as a proliferation marker. In the present study, therefore, we characterized the expression of CENP-F in non-Hodgkin's lymphoma by immunohistochemical techniques to detect potential dysregulation of the protein or to establish CENP-F as a reliable proliferation marker. A polyclonal rabbit antibody reacting with CENP-F was prepared and used for immunohistochemical analyses after antigen retrieval. The rabbit antibody produced immunofluorescence patterns, flow cytometric profiles, and Western blot reactivity identical to those of the human autoantibody used in earlier studies. The percentage of CENP-F-positive and Ki-67-positive cells, as well as the labeling index, S-phase time, and potential doubling time, derived from in vivo iododeoxyuridine incorporation, were evaluated in 41 non-Hodgkin's lymphomas. Aggressive lymphomas showed higher CENP-F values than did indolent cases (10.1 vs. 3.4%). The percentage of CENP-F-positive cells correlated significantly to the S-phase fraction (r(s) = 0.68), the Ki-67 index (r(s) = 0.56) and the labeling index of iododeoxyuridine (r(s) = 0.47), as well as to S-phase time and potential doubling time (r(s) = 0.34 and -0.40). A lower fraction of CENP-F positive cells was found, compared with the Ki-67 index (4.9 vs. 9.4%), supporting previous observations that CENP-F was expressed in a fraction of actively growing cells. These correlative data indicate that CENP-F expression defines a specific subpopulation of growing cells and that no clear evidence for dysregulation was found. Accordingly, CENP-F seems to be a useful proliferation marker for formalin-fixed and paraffin-embedded material. PMID- 9950166 TI - Human immunodeficiency virus-rich multinucleated giant cells in the colon: a case report with transmission electron microscopy, immunohistochemistry, and in situ hybridization. AB - Multinucleated giant cells (MNGCs) expressing the human immunodeficiency virus (HIV) are characteristically found in hyperplastic tonsils and adenoids, acquired immunodeficiency syndrome encephalitis, vacuolar myelopathy, and lymph nodes coinfected with opportunistic pathogens. We identified similar polykaryons in the hyperplastic gut-associated immune system of an HIV-infected patient. Colonic biopsy specimens from this patient with heme-positive stools were studied by light and transmission electron microscopy (TEM), immunohistochemistry, and in situ hybridization for HIV-specific RNA. No bleeding source was identified by endoscopic or light microscopic examination of the biopsied tissues. There was diffuse and nodular lymphoid hyperplasia with germinal centers. HIV RNA-positive and p24 gag-positive Langhans'-type MNGCs and mononuclear cells (MNCs) were present within the lamina propria The MNGCs and MNCs were identified as macrophages on the basis of TEM and expression of CD68, HAM56, and lysozyme markers. They also expressed S100 protein, a marker of dendritic/Langerhans' cells, but they lacked Birbeck granules by TEM. In situ hybridization demonstrated RNA expression by MNGCs, MNCs, and follicular dendritic cells. TEM revealed budding and mature HIV particles on the plasma membranes of MNGCs, MNCs, and follicular dendritic cells. We conclude, therefore, that hyperplastic gut associated immune systems can contain HIV-positive MNGCs and MNCs of the type seen in tonsils and adenoids and opportunistic pathogen-infected lymph nodes. Associated with immune activation, macrophages can express markers of dendritic/Langerhans' cells, cell types derived from the same CD34-positive bone marrow progenitor. PMID- 9950168 TI - Cytogenetic and cytologic features of chondroid lipoma of soft tissue. AB - The cytologic and cytogenetic findings of chondroid lipoma, a rare benign tumor of soft tissue, have not been described. This report details the morphologic features of a fine-needle aspiration biopsy specimen and describes a novel cytogenetic finding. The main cytologic features consisted of clustered, variably mature, multivacuolated, hibernoma-like cells enmeshed in a capillary plexus, with a background of chondromyxoid material. Cytogenetic analysis revealed a balanced translocation t (11, 16)(q13;p12-13) distinct from the known translocation involving 16p11 in myxoid and round-cell liposarcoma. The 11q13 breakpoint was previously noted in hibernomas, raising the possibility of a common genetic deregulation. PMID- 9950170 TI - Much ado about doing nothing. AB - Negative stereotypes about certain kinds of medical specialists are commonly expressed by physicians in the presence of medical students. The authors of this brief essay, an academic pathologist and an academic internist, suggest that these sorts of remarks may have a range of deleterious effects on students. We wish to sensitize medical school faculty to this problem. Moreover, we propose that in an era in which a team approach to patient care is often required, the promotion of positive doctor-doctor relationships is critical and should be an integral part of medical education. PMID- 9950167 TI - Congenital syphilis in a newborn: an immunopathologic study. AB - A 3-week-old girl presented to the emergency room with respiratory distress and generalized maculopapular rash. The newborn was hospitalized with a presumptive diagnosis of congenital syphilis, but she died after 2 days of therapy. Tissue from the gastrointestinal tract, brain, liver, spleen, and lung was studied by using direct fluorescent antibody and immunohistochemical analysis (IHC) for Treponema pallidum. The inflammatory infiltrate was characterized by using IHC against CD3, CD20, CD68, and smooth muscle actin. The diagnosis of congenital syphilis was confirmed by demonstrating spirochetes in tissues with IHC and direct fluorescent antibody examination. IHC showed abundant treponemes in the small intestine and liver and occasional spirochetes in the meninges. Bacteria were seen as intact spirochetes, granular staining, or large extracellular collections of antigen. A constant pathologic feature throughout the tissues was concentric macrophage (CD68-positive) infiltrate around vessels, giving an onion skin appearance. IHC identified the macrophages as the prime immune response in congenital syphilis. PMID- 9950169 TI - Cytospray fixation of frozen intraoperative sections. AB - Preservation of cellular morphologic features is well known to be a limit of intraoperative frozen sections. Various techniques have been proposed to improve tissue details, the most common being ethanol immersion of cryostatic slide. We tested fixation with spray formulation for cytology smears on intraoperative frozen section from different organs to obtain a quick alcoholic fixation and a ready-to-use method. Our results of comparative study showed that cytospray fixation of frozen sections provide a significant improvement of cellular details, that it is quick, simple, economic, and that it does not require preorganization. PMID- 9950171 TI - Non quisquam melior medicus, quam fidus amicus: there is no better physician than a true friend--Cato. PMID- 9950172 TI - Towards long-term dialysis: a personal view. PMID- 9950174 TI - Cellulose carbamates and derivatives as hemocompatible membrane materials for hemodialysis. AB - Dialysis membranes made from regenerated cellulose are under dispute because of their alleged lack of hemocompatibility. The introduction of membranes from synthetically modified cellulose, like cellulose acetate or Hemophan, has proven, however, that hemocompatible membranes can be fabricated from cellulose by means of chemical surface modifications. In addition to membranes made from modified cellulose like ethers or esters, which were investigated in earlier experiments, we looked for further cellulose modifications to be assessed for their hemocompatibility. For this purpose, we synthesized a series of cellulose carbamate derivatives to profit from the excellent hemocompatibility pattern of the urethane family. In vitro investigations on membranes made from these cellulose modifications proved a direct relationship between the degree of modification and hemocompatibility. This was proven for the following 3 representative hemocompatibility parameters: complement C5a generation, thrombin antithrombin (TAT) III formation, and platelet count (PC). As already shown for modifications made from cellulose esters, a direct dependency between improved hemocompatibility and the degree of substitution (DS) in the cellulose molecule could be found. In our experiments, a degree of substitution below a value of 0.1 led to a nearly complete suppression of complement activation for all cellulose carbamates under investigation. In contrast to data on cellulose esters, we observed that molecular weight or molecular conformation of chemical substituents exerted only a minor effect on the hemocompatibility pattern. In addition, data on cellulose carbamate esters (e.g., cellulose succinate-phenyl-carbamate) show that a simultaneous but balanced substitution with hydrophilic and hydrophobic groups at the surface of the cellulose polymer is a further prerequisite for optimal hemocompatibility. It seems that the carbamate configuration per se has a positive effect on the hemocompatibility pattern of synthetically modified cellulose membranes. PMID- 9950173 TI - Development of a new approach to vascular access. AB - Three modes of access for hemodialysis (HD) have been available for over 20 years, the native arterial to venous (A-V) fistula, the polytetrafluorethylene (PTFE) graft fistula, and the central venous catheter. Overall, vascular access remains the single most costly source of morbidity and hospitalization in HD patients, indicating a severe need for improvement in this area. A significant contributor to access morbidity is the HD catheter, which protrudes through the skin and is subject to frequent infection. Subcutaneous ports have been developed to overcome this problem with catheters, but their application to HD has been elusive for 2 reasons, the use of a degradable septum that becomes vulnerable to infection with the use of large bore needles and the presence of a nonlinear flow path which produces damage to blood cells and stimulates thrombus formation at the required high flow rates. A new device, the Dialock, overcomes these objections by its use of a mechanical valve that maintains a linear flow path without directly contacting the blood. Results of a pilot study with 23 patients demonstrated a 78% cumulative survival rate after 1 year with a reduced rate of infection compared to catheters and sustained blood flow of 330 ml/min. The device represents a most promising advance in vascular access. PMID- 9950175 TI - Interactions between platelets and leukocytes during hemodialysis. AB - The formation of platelet-leukocyte microaggregates has been observed in a variety of conditions. When platelets and leukocytes coaggregate, in general, a reciprocal activation occurs when both cells are activated, and the interactions between activated platelets and leukocytes may be relevant in both hemostasis and inflammatory processes. The study of platelet-leukocyte interactions in hemodialysis offers the novel aspect of cellular-cellular interaction as a new parameter for evaluating the biocompatibility of dialyzer membranes. This article reviews the investigations of the interactions between platelets and leukocytes during hemodialysis and the pathophysiologic implications which may stem from such interactions. PMID- 9950176 TI - Platelet-leukocyte aggregates during hemodialysis: effect of membrane type. AB - Hemodialysis is associated with the formation of platelet-leukocyte aggregates. Whether this phenomenon is hemodialysis (HD) membrane dependent is unclear. To evaluate this process, we examined respectively platelet activation (anti-CD41, anti-CD62, and antifibrinogen monoclonal antibodies [MoAb] binding), leukocyte activation (CD11b expression), and the appearance of platelet specific antigens on leukocytes as an index of platelet-leukocyte aggregation during HD using 3 different membrane materials, Cuprophan, Hemophan, and polysulfone. Flow cytometric techniques and specific MoAb were used. All parameters were assayed 5 min after initiation of HD to avoid the confounding variable of leukopenia and resultant cell subpopulation analysis. Platelet activation (anti-CD62 and antifibrinogen binding) occurred only with Cuprophan. All 3 membranes induced equivalent increases in CD11b expression on neutrophils and similarly increased the binding of anti-CD41 to neutrophils, reflecting an increment in the formation of platelet neutrophil aggregates. However, only Cuprophan induced an increase in anti-CD62 binding to neutrophils, suggesting that the aggregated platelets linked to neutrophils were activated. Increased anti-CD41 binding by monocytes was similarly observed with all 3 membranes. However, only polysulfone induced an increase in CD11b expression and fibrinogen binding to monocytes. We conclude that while the formation of platelet leukocyte aggregates appears to be a universal phenomenon in HD occurring with a variety of membrane types, subtypes of this phenomenon consisting of activated platelets and fibrinogen binding may be membrane dependent. This phenomenon may serve as a new biocompatibility parameter and may shed light on some of the biologic consequences of hemodialysis. PMID- 9950177 TI - Defining the microbiological quality of dialysis fluid. AB - With increasing awareness about the degree and the potential impact of microbiological contamination in dialysis fluids, there is a desire to improve their microbiological quality. To achieve this goal, the origin of the microbiological contamination has to be identified. The water, the bicarbonate concentrate, and the fluid distribution system can be major contributors. Regular disinfection of the entire fluid path is necessary to prevent the formation of biofilm. The bicarbonate concentrate should be handled with special attention because it constitutes an excellent growth medium for microflora that may not be detected with regular assays. With a well maintained reverse osmosis (RO) system, frequent disinfection of the entire flow path, and microbiological awareness, it is possible to produce dialysis fluid that meets the most stringent standard (<10(2) colony forming units (CFU)/ml and <0.25 IU/ml of endotoxin). Adding a step of ultrafiltration just before the dialyzer can make the dialysis fluid ultrapure (<10(-1) CFU/ ml and <0.03 IU/ml). One additional step of controlled ultrafiltration provides sterile and pyrogen-free fluids (<10(-6) CFU/ml and <0.03 IU/ml) that can be used for infusion. PMID- 9950178 TI - Evaluation of urea kinetics utilizing stable isotope urea and pharmacokinetic modeling. AB - The determination of urea kinetics plays a central role in clinical dialysis prescription. There persist, however, significant limitations to current approaches, particularly as they pertain to rigorous explorations of urea metabolism, distribution, and removal. This report describes methodologies designed to address these limitations by coupling a stable nitrogen isotope method with strict compartmental pharmacokinetic modeling. The findings of the present study can be summarized as follows. First, the use of stable isotope labeled exogenous urea is a reliable clinically applicable method for determination of urea kinetics. Second, this method offers significant advantages in that it allows for an accurate measurement of urea distribution space, endogenous urea production, and non-renal clearance of urea. Third, this method is significantly more rigorous than urea kinetic models that utilize only endogenous urea and do not carefully fit data points. Finally, pharmacokinetic modeling suggests that a two-compartment model satisfies all aspects of urea distribution and removal, but these compartments should not be equated with specific physiologic spaces. The combination of stable isotope urea compartmental modeling is a rigorous methodology for the assessment and validation of urea kinetics. PMID- 9950179 TI - Hepatitis C virus infection in dialysis: a continuing problem. AB - Patients on chronic dialysis are at increased risk of acquiring parenterally transmitted hepatitis viruses from blood product transfusions or nosocomial transmission in hemodialysis units, and biochemical abnormalities in liver function are seen in 10-44% of patients on chronic hemodialysis. In the past, hepatitis B virus (HBV) was the major cause of parenterally transmitted viral hepatitis in dialysis patients, and the remaining cases were attributed to non-A, non-B hepatitis (NANBH). The discovery of the hepatitis C virus (HCV) has shed light on the cause and clinical course of NANBH in patients on dialysis. The current debate is focused on strategies to reduce the transmission of HCV among dialysis patients and to lessen the consequences of liver disease among patients already infected. PMID- 9950180 TI - Survival of patients on chronic hemodialysis: single center experience. AB - Patient survival from our hemodialysis (HD) center over the past 11 years was analyzed. Four hundred four patients, 212 female and 192 male, were treated by chronic intermittent HD. Patients were offered standard acetate-cellulosic membranes of 1.0-1.3 m2. During this period 181 patients died. One hundred three patients were transferred to other HD centers, and some were transplanted. One hundred twenty patients are still on HD treatment. The 5 year survival rate of patients treated in our center was 58%. Women lived longer than men, and age correlated significantly with survival rate. Patients with chronic glomerulonephritis and adult polycystic kidney disease had the best survival rates while diabetic patients and those with post hypertensive nephropathy had the poorest survival rates. Forty-four percent of patients had a cardiac related cause of death, cerebrovascular accident was the cause in 15%, and 11% died due to septic condition (infection) while 8% died due to liver disease. PMID- 9950181 TI - The anemia in continuous ambulatory peritoneal dialysis patients is related to Kt/V index. AB - Anemia in chronic renal failure causes a number of serious problems to the patient. As a result, it is imperative to make use of all rational options to alleviate it. The present study addresses the question, the answer to which is not yet known, whether or not the degree of anemia depends on the efficacy of continuous ambulatory peritoneal dialysis (CAPD) and, if so, what the importance of peritoneal clearance and residual renal function is. A significant correlation between the hematocrit (Hct) and the total weekly Kt/V index (tKt/V) (r = 0.61, p<0.01), total weekly creatinine clearance (tCLCR) (r = 0.50, p<0.05), and residual glomerular filtration rate (r = 0.43, p<0.05) was demonstrated in a group of 22 CAPD patients. Stepwise regression analysis showed that of all the variables monitored, Hct depends exclusively on tKt/V (p<0.01, r2 = 0.37). The value of Hct in a group of patients with a tKt/V <2.3 (n = 15) was 28.9+/-1.2% (arithmetic mean +/- SEM) while in a group with a tKt/V > or =2.3 (n = 7), it was 35.1+/-1.9% (p<0.01). On dividing tKt/V and tCLCR into their peritoneal and renal components, a significant correlation between Hct and renal Kt/V (r = 0.47, p<0.05) was found; stepwise regression analysis identified renal Kt/V (p<0.01) and peritoneal Kt/V (p<0.05), with R2 = 0.38 as major variables with an effect on Hct. The authors conclude the efficacy of blood purification is another factor affecting renal anemia in CAPD patients. The relationship between anemia and blood purification is best expressed using the Kt/V index. The Kt/V provided by one's own kidneys seems to be of greater importance for anemia than the Kt/V provided by peritoneal dialysis. The results provide the basis for prospective interventional studies. PMID- 9950182 TI - Pathophysiological role of leptin in patients with chronic renal failure, in kidney transplant patients, in patients with essential hypertension, and in pregnant women with preeclampsia. AB - This paper is a summary of results obtained in our studies on leptinemia in patients with chronic renal failure treated with recombinant human erythropoietin (rHuEPO), in kidney transplant patients, in patients with essential hypertension, and in pregnant women with preeclampsia. In this study, we found that rHuEPO treatment has a suppressive effect on leptinemia in patients with endstage renal failure. These results suggest that the appetite stimulating effect of rHuEPO may be mediated by a reduction of leptin synthesis and release. At the early stage of successful kidney transplantation, a significant decline of leptinemia was noticed, which was not related either to the excretory function of the graft or the kind and dose of immunosuppressants. In kidney transplant patients with grafts functioning well for 2.5 years, significantly elevated leptinemia was found. From these results, we may conclude that factors other than the excretory function of the graft and the kind and dosage of immunosuppressants may be involved in the pathogenesis of abnormal leptinemia in these patients. Both in normotensive subjects and patients with essential hypertension, a positive correlation was found between leptinemia and mean blood pressure, suggesting that leptin may be involved in the regulation of blood pressure. Both healthy and preeclamptic pregnant women show higher leptinemia than nonpregnant women. In preeclamptic women, leptin levels in maternal vein blood, umbilical cord blood, and amniotic fluid were significantly higher than respective values found in healthy pregnant women. In contrast to healthy pregnant and nonpregnant women, in women with preeclampsia, no correlation was found between the body mass index (BMI) and leptinemia. In preeclamptic women the abnormally elevated leptinemia was not related to blood pressure. Finally, no correlation was found between leptinemia in maternal and umbilical cord blood. From these studies, it follows that the elucidation of abnormal leptin secretion in the pathogenesis of preeclampsia needs further study. PMID- 9950183 TI - Importance of sodium dodecyl sulfate pore-graduated polyacrylamide gel electrophoresis in the differential diagnostic of Balkan nephropathy. AB - Balkan nephropathy (BN) is an endemic disease, which leads to end-stage renal failure and artificial renal replacement therapy. Pathologically it is characterized by progressive interstitial nephritis in a large population of villages situated in the proximity of a bend of the Danube up to a distance of 100 km from the river in several parts of Bulgaria, Romania, and the former Yugoslavia. The urinary proteins of 19 patients with BN from the region of Vratza, Bulgaria were examined using ultrathin layer sodium dodecyl sulfate (SDS) pore-graduated polyacrylamide gel electrophoresis (PAGE) and silver staining. The documentation of urinary proteins pattern was performed using laser densitometry and consecutive electronic processing for the purpose of characterizing and quantifying protein excretion. Our results show that the proteinuria of BN is predominantly tubular, consisting of low molecular weight species (10-65 kilodaltons). The amount of tubular protein changes with the progression of the disease. SDS-polyacrylamide gel electrophoresis (PAGE) is a diagnostic method for early diagnosis of tubular failure in BN. Using our method of SDS-PAGE, tubular failure can be detected even at a total protein concentration below 0.1 g/L and when the serum creatinine concentration is normal. Additionally, our method of SDS-PAGE supports the differentiation of BN from glomerular disease. PMID- 9950184 TI - Fractionated plasma separation and adsorption system: a novel system for blood purification to remove albumin bound substances. AB - The removal of albumin bound substances has gained increasing interest in different diseases, especially in acute and chronic liver disease. Therefore, a new system, the fractionated plasma separation and adsorption (FPSA) system, was developed based on combined membrane and adsorbent blood purification techniques. The most important contribution to the FPSA system was the development of a new polysulfone hollow-fiber filter, which is characterized by a sieving coefficient of 0.89 for human serum albumin (HSA) but only of 0.17 for fibrinogen, and 0 (zero) for IgM immunoglobulins. Using a closed filtrate circuit connected to the new polysulfone filter which integrates 1 or 2 adsorption columns and also a high flux dialyzer adapted to a dialysis machine, the FPSA system opens excellent possibilities for the relatively specific removal of albumin bound substances from the blood such as albumin bound bilirubin or even tryptophan. In comparison to other systems (for example, the Molecular Adsorbent Recirculating System [MARS] and albumin dialysis systems), the FPSA system enables much higher elimination of strongly bound albumin substances. The first clinical investigations have recently started based on a modified dialysis machine designed with all necessary safety measures. PMID- 9950187 TI - Influence on blood of plasticized polyvinyl chloride: significance of the plasticizer. AB - An investigation has been made of the significance of the level of the plasticizer di-(2-ethylhexyl)phthalate at the surface of plasticized polyvinyl chloride for interactions with blood components. Plasticized polyvinyl chloride before and after treatment with methanol to reduce the plasticizer surface level was assessed in terms of fibrinogen and albumin adsorption with unplasticized polyvinyl chloride acting as a control. As the plasticizer surface level decreased, fibrinogen adsorption decreased almost linearly while albumin adsorption increased initially before decreasing slightly. The investigation indicates that reduction in the amount of plasticizer at the surface improves the blood compatibility of plasticized polyvinyl chloride, and the influence on blood is due primarily to the plasticizer rather than the polyvinyl chloride itself. PMID- 9950185 TI - Investigation of plasma protein adsorption on functionalized nanoparticles for application in apheresis. AB - Particles with specific ligands for the adsorption of plasma proteins can be used in therapeutic or preparative apheresis. The development of these particles may benefit from an improved knowledge of the relationship between protein adsorption and the structure of ligands. Nanoparticles were functionalized with aliphatic diamines of increasing chain length; with the amino acids lysine, tryptophan, histidine, and their corresponding amines; and with tryptophan and histidine spaced with diamines of different length. Suitable protocols were developed for the washing of particles and the subsequent desorption of proteins adsorbed from human plasma. The adsorption pattern, as well as the quantification of the overall adsorption of proteins on these modified particles, was investigated with gel electrophoresis. This was followed by immunoblotting which yielded specific assessments of bound human serum albumin and fibrinogen. The comparison of protein adsorption with surface charge density and measured hydrophobicities yielded no simple correlations although in general more hydrophobic ligands bound higher quantities of protein. The detection of human serum albumin yielded similar results because it was observed for overall protein adsorption while the adsorption of fibrinogen expressed a different pattern. In this case, particular nanoparticles functionalized with aliphatic diamines bound significantly higher amounts of fibrinogen than all other ligands. PMID- 9950186 TI - Biocompatible magnetic polymer carriers for in vivo radionuclide delivery. AB - The magnetic guidance of antiplastic and antibacterial agents as well as x-ray and MRI contrast substances in vivo by means of magnetic particles has been attempted repeatedly during the last 2 decades with more or less success. When using microparticles, the circulation time in the blood, the biodistribution, and to a greater or lesser extent, the specific targeting are determined by the uniformity of size, chemical composition, surface modification, and the electric surface charge. The electrophoretic mobility is an important parameter for the prediction of the usefulness of the prepared particle, modified by chemical and biological molecules. For its success, radionuclide therapy depends on the critical relationship between the amount of radioactive isotopes in the target tissue and in critical normal tissue. Because the implementation of radioimmunotherapy for the treatment of cancer has proven to be considerably more difficult than initially anticipated, we propose the use of magnetic nanospheres for the well directed delivery of radionuclides to a tumor after the intravenous administration of the biodegradable colloidal suspension. PMID- 9950188 TI - In vitro comparison study of CD63 and CD62P expression after contacting leukocyte filters. AB - CD63 and CD62P have been recognized as platelet activation markers. This study investigated the secretion of these antigens to compare the platelet activation between a newly developed stainless steel leukocyte filter (SSLF) and 7 polyester or polyurethane commercially available leukocyte filters. Flow cytometry demonstrated that the SSLF initiated significantly smaller effects in terms of mean fluorescence intensity of CD63 (p<0.03) and of the amount of CD62P expressing platelets (p<0.002) compared to the polyurethane filters. However, there was no statistical difference between the SSLF and polyester filters. The result of this study suggests that the SSLF caused less platelet activation than the polyurethane filters and has biocompatible characteristics comparable to the currently available polyester filters. Stainless steel was selected because of its physicochemical conductivity. With these results, further evaluation of the SSLF will be continued in an attempt to develop an active immunomodulator using this unique characteristic. PMID- 9950189 TI - The effects of various extracellular matrices on renal cell attachment to polymer surfaces during the development of bioartificial renal tubules. AB - Extracellular matrices (ECM) are utilized for obtaining better cell attachment to polymer surfaces in cell cultures. To establish beneficial bioartificial renal tubules, tubular epithelial cells and ECM were investigated in this study. MDCK cells and KU-2 cells were seeded onto 96 well plates which had been precoated with collagen types I and IV, laminin, and fibronectin. The culture media were removed and replaced with new ones at 15, 30, 60, 90, 120, and 150 min and 24 h after start time to evaluate the incubation time effects. The degrees of cell attachment onto ECM were measured by MTT assay. In the MDCK cell culture, better cell attachment was observed between 60 min and 24 h after incubation start time with the use of laminin at a concentration of 5 microg/ml, 60 min and more after incubation start time with the use of fibronectin at the concentrations of 1 and 4 microg/ml, or 30 min and more after incubation start time with the use of fibronectin at the concentrations of 16 and 32 microg/ml. On the other hand, in the KU-2 cell culture, better cell attachment was observed between 15 and 60 min after the incubation start time or 24 h after the incubation start time with the use of laminin at a concentration of 40 microg/ml. These data suggest that various cells possibly each have a most suitable ECM kind, best concentration, and best incubation time. PMID- 9950190 TI - Chaotic dynamics in circulation with Tohoku University vibrating flow pump. AB - For the development of a totally implantable ventricular assist system (VAS), we have been developing the vibrating flow pump (VFP), which can generate oscillated blood flow with a relative high frequency (10-50 Hz) for a totally implantable system. In this study, the effects of left ventricular assistance with this unique oscillated blood flow were analyzed by the use of nonlinear mathematics for evaluation as the whole circulatory regulatory system, not as the decomposed parts of the system. Left heart bypasses using the VFP from the left atrium to the descending aorta were performed in chronic animal experiments using healthy adult goats. The ECG, arterial blood pressure, VFP pump flow, and the flow of the descending aorta were recorded in the data recorder during awake conditions and analyzed in a personal computer system through an A-D convertor. By the use of nonlinear mathematics, time series data were embedded into the phase space, the Lyapunov numerical method, fractal dimension analysis, and power spectrum analysis were performed to evaluate nonlinear dynamics. During left ventricular assistance with the VFP, Mayer wave fluctuations were decreased in the power spectrum, the fractal dimension of the hemodynamics was significantly decreased, and peripheral vascular resistance was significantly decreased. These results suggest that nonlinear dynamics, which mediate the cardiovascular dynamics, may be affected during left ventricular (LV) bypass with oscillated flow. The decreased power of the Mayer wave in the spectrum caused the limit cycle attractor of the hemodynamics and decreased peripheral resistance. Decreased sympathetic discharges may be the origin of the decreased Mayer wave and fractal dimension. These nonlinear dynamic analyses may be useful to design optimal VAS control. PMID- 9950191 TI - A simplified single pump circuit for cardiac bypass with autogenous oxygenation. AB - A simplified extracorporeal circulation (ECC) assemblage with autogenous oxygenation (AO) using a single centrifugal pump was tested in dogs. The transpulmonary gradient was obtained by increasing pressure in the right atrium through volume expansion and decreasing it in the left atrium by collecting the blood from the pulmonary veins in a reservoir placed below the level of the animal, generating a siphon effect. This arrangement dispenses with a right side pump. The heart was electrically fibrillated after perfusion was started and defibrillated at the end of the bypass. This ECC circuit allowed the maintenance of adequate hemodynamic and blood gas parameters during the bypass. The operating field and the mobility of the heart were equivalent to that of conventional cardiopulmonary bypass (CPB). We conclude that the use of a single centrifugal pump simplifies the autogenous oxygenation approach, making it a practical choice for the coronary artery bypass graft (CABG) procedure. PMID- 9950192 TI - Cytogenetic aberrations in Ewing sarcoma: are secondary changes associated with clinical outcome? AB - BACKGROUND: Ewing sarcoma is associated with a nonrandom pattern of primary and secondary chromosomal aberrations. Whereas the finding of rearrangements of chromosome 22, usually in the form of a balanced translocation t(11;22)(q24;q12), is important diagnostically, nothing is known about the potential prognostic impact of the secondary chromosomal aberrations. PROCEDURE: During a 1 3-year period, short-term cultured tumor samples from 21 children and young adults with Ewing sarcoma were cytogenetically analyzed successfully. RESULTS: Clonal chromosome aberrations were detected in 18 patients, 17 of whom had the characteristic t(11;22)(q24;q12) or variants thereof. The most frequent secondary change was +8, followed by +12, +2, +5, +9, +15, and gain of material from the long and short arms of chromosome 1. The only recurrent secondary change that was restricted to tumors from the ten patients that were dead at latest follow-up was gain of 1q material. Furthermore, all three patients with tumors with chromosome numbers over 50 had died, and the only patient with a tumor karyotype lacking chromosome 22 rearrangement was alive without evidence of disease. CONCLUSIONS: These data and previously published results indicate that the karyotypic pattern not only may be of diagnostic significance but also may be important prognostically. PMID- 9950193 TI - Detection of neuroblastoma in bone marrow by immunocytology: is a single marrow aspirate adequate? AB - BACKGROUND: Except at diagnosis and relapse, when gross disease is present, histologic evaluation is less sensitive than immunocytology (IC) of bone marrow for detecting metastatic neuroblastoma. We examined whether the chance of a positive IC from a single marrow site was comparable to an IC of pooled marrow from multiple sites. PROCEDURE: We carried out 47 marrow examinations on 29 patients with high-risk neuroblastoma on therapy. Each examination consisted of histologic evaluation of four aspirates and two biopsies (six sites), IC of a 2.5 5-mL heparinized sample from a single site (the right posterior iliac crest; IC RPIC), as well as IC of 8-10 mL of heparinized marrow pooled from bilateral anterior and bilateral posterior iliac crests (IC-pooled). IC was performed using a panel of monoclonal antibodies specific for ganglioside GD2. RESULTS: The number of GD2-positive tumor cells detected by IC-pooled had a strong linear correlation with that by IC-RPIC (R = 0.91), although IC-pooled detected an average of 3.3 times more GD2-positive cells. Of 47 examinations, 15 tested positive by histology (6 sites), 20 by IC- pooled, and 17 by IC-RPIC. Among 29 patients, the level of agreement between IC-RPIC and IC-pooled was generally good (kappa statistic > or = 0.72), giving a false negative rate of < or = 30%. CONCLUSIONS: Compared to conventional histologic examinations, immunocytology of a single marrow aspirate generally agrees with that of marrow pooled from six sites. However, the false negative rate may be too high in the setting of examination prior to bone marrow or stem cell harvest. PMID- 9950194 TI - High-dose chemotherapy followed by peripheral blood stem cell rescue for metastatic rhabdomyosarcoma: the experience at Chicago Children's Memorial Hospital. AB - BACKGROUND: Because outcome for metastatic rhabdomyosarcoma remains poor with standard therapy, and because some patients with extensive unresectable metastatic rhabdomyosarcoma are unable to tolerate standard therapy with the associated large radiation fields, peripheral blood stem cell rescue (PBSCR) following high-dose chemotherapy was offered as consolidative therapy for patients with Stage 4/Group IV rhabdomyosarcoma. PATIENTS AND METHODS: Eight patients with Stage 4/Group IV rhabdomyosarcoma were diagnosed from May, 1992, through November, 1994. Consolidative PBSCR following thiotepa 300 mg/M2 on days 7, -6, and -5; cyclophosphamide 1,500 mg/M2 on days -5, -4, -3, and -2; and carboplatin 600 mg/M2 on days -3 and -2 was offered to those patients who achieved a complete remission with multimodality therapy. Patients with extensive metastatic disease who did not receive full doses of radiation to all sites of disease remained eligible for high-dose chemotherapy and PBSCR. RESULTS: Five of eight patients achieved a complete response. Four patients underwent PBSCR. One of the four patients is alive without evidence of disease 53 months post-PBSCR. All other patients died of progressive disease. CONCLUSIONS: These results, along with the existing literature, show no advantage of high-dose chemotherapy followed by PBSCR as consolidative therapy for patients with Stage 4/Group IV rhabdomyosarcoma over standard dose chemotherapy, radiation, and surgery. For patients with extensive, unresectable disease at diagnosis who cannot receive radiation to all areas of disease based on concerns of marrow reserve, high-dose chemotherapy followed by PBSCR does not appear to provide adequate local control and cannot be offered as curative therapy. PMID- 9950195 TI - Renal function following combination chemotherapy with ifosfamide and cisplatin in patients with osteogenic sarcoma. AB - BACKGROUND: Ifosfamide and cisplatin are active agents that are currently used in the treatment of osteosarcoma. Nephrotoxicity has been reported following their use in combination and alone. This study evaluates renal function in children and adolescents (median age 16 years) at least 3 months following completion of a chemotherapy regimen which included 54 g/m2 ifosfamide, 360 mg/m2 cisplatin, doxorubicin, and high-dose methotrexate. PROCEDURE: Mean glomerular filtration rate (GFR) was determined by inulin or iothalamate clearance; proximal tubular function was evaluated by measuring fractional excretion of glucose (FEglu), tubular maximum phosphate reabsorption per GFR (TMP/GFR), FE of urate, and 24 hour amino acid excretion. Distal tubular function was evaluated by 24-hour urinary calcium, FE of magnesium, and urinary osmolality after water deprivation. Twenty-four-hour urinary protein excretion was measured. RESULTS: The mean GFR was 97 ml/min/1.73 m2. Although 10 of 24 patients had GFRs lower than normal, the lowest value was only 22% below the lower limit of normal and would not account for any clinical compromise. Proximal tubular function evaluation revealed normal FEglu, normal mean TMP/GFR values, and high FE of urate (1 5.7%). Two of twenty four patients were shown to have mild generalized aminoaciduria. Distal tubular function evaluation showed normal 24-hour urinary calcium levels (mean 3.4 mg/kg) and FE of magnesium as well as normal urinary osmolality. Twenty-four-hour urinary protein excretion was normal in all patients. CONCLUSIONS: The lack of clinically significant renal abnormalities observed in patients who received combination chemotherapy with ifosfamide and cisplatin for osteosarcoma is encouraging for future osteosarcoma protocol development. PMID- 9950196 TI - Synovial sarcoma mimicking desmoplastic small round-cell tumor: critical role for molecular diagnosis. AB - BACKGROUND: The identification of recently described nonrandom chromosomal defects specific for various small round-cell and spindle-cell sarcomas can eliminate diagnostic uncertainty arising from the clinical and histopathologic overlap of soft tissue neoplasms. METHODS: A 26-year-old man presented with bulky abdominal-pelvic disease. Immunohistochemical and molecular studies on tumor were performed. Treatment was instituted using cycles of high-dose cyclophosphamide (4,200 mg/m2) with doxorubicin (75 mg/m2). RESULTS: Clinical findings pointed to desmoplastic small round-cell tumor. The tumor was histologically undifferentiated and immunoreactive for vimentin but negative for other markers. Reverse transcriptase-polymerase chain reaction revealed the SYT/SSX2 fusion transcript of the synovial sarcoma t(X;18) chromosomal rearrangement. The high dose chemotherapy, plus surgery, achieved a complete remission, but recurrent disease emerged 13 months from diagnosis. CONCLUSIONS: This clinically unique case of synovial sarcoma highlights how the use of now readily available molecular techniques will allow more accurate appraisals of the incidence and anatomic distribution of soft tissue neoplasms-information that bears upon pathogenesis and treatment. This case confirms the utility of high-dose alkylator based therapy for synovial sarcoma. It also demonstrates that with nonlocalized solid tumors, the eradication of minimal residual disease remains an elusive goal. One alternative involves immunologic attack against markers derived from tumor-specific chromosomal defects such as those found in our patient. PMID- 9950198 TI - Clinical and prognostic aspects of adrenocortical neoplasms in childhood. AB - BACKGROUND: A retrospective study of 54 children was undertaken to define the clinical presentation and secretory patterns of adrenal tumors and to evaluate the outcome of surgical resection and medical therapy. PROCEDURES: Different factors were studied in univariate and multivariate analysis by using the Cox proportional hazard model. RESULTS: Median age at diagnosis was 4 years. Boys and girls were affected equally. The disease was revealed by virilization (61%) or by a palpable mass (39%) with a 0.1-5.5 year delay from initial symptoms. At initial examination, we found that 76% of children were virilized. Ninety-four percent of the tested tumors secreted androgens, which were associated with glucocorticoids in 36%. Adrenal tumors in children were smaller than in adults. Half of them measured less than 10 cm. There were recurrences in 40% of children. The survival rate at 5 years was 49%, 70% if resection was microscopically complete and 7% if not (P < 0.001). CONCLUSIONS: In children, rare adrenal tumors have different diagnostic and prognostic characteristics than in adults; however, recurrences remain frequent. The efficacy of chemotherapy, mainly o,p'-DDD (Mitotane), remains to be evaluated in comparative trials. PMID- 9950197 TI - Primary epidural non-Hodgkin lymphoma: spinal cord compression syndrome as the initial form of presentation in childhood non-Hodgkin lymphoma. AB - BACKGROUND: Primary epidural non-Hodgkin lymphoma (NHL) is a rare but devastating event in pediatric oncology. Spinal cord compression due to an epidural mass from NHL, although it presents as a localized problem, in fact, is a systemic disease. Over the last 3 decades, aggressive systemic treatments with central nervous system prophylaxis have been designed with improving results. PROCEDURE: We reviewed the 20-year experience of the treatment of NHL with the LSA2-L2 protocol in our institution. Among 256 patients treated, five presented with primary epidural mass. Clinical features, treatment, and outcome of those five patients are presented. RESULTS: Three patients out of five responded favorably, and after a median follow-up of 10 years, they are cured. After presenting with paraplegia, functional and neurological recoveries were excellent. Of the patients who failed treatment, relapse occurred early, either during the treatment or right after completion of therapy. The relapses were within the central nervous system as well as systemic. CONCLUSIONS: Patients with primary epidural NHL presented with long histories of persistent back pain. Plain films of the spine were useless. All patients were diagnosed when neurologic damage had already been established. However, when the epidural NHL is treated aggressively with systemic chemotherapy and vigorous rehabilitation, the prognosis for complete neurological recovery and cure of the lymphoma is encouraging. PMID- 9950199 TI - Concomitant chemoradiotherapy for incompletely resected supratentorial low-grade astrocytoma in children: preliminary report. AB - BACKGROUND: In incompletely resected low-grade supratentorial astrocytoma, long term survival is poor; the effect of any additional treatment to surgery still remains poorly defined. The aim of this study was to evaluate the response, the survival, and the benefit of concomitant chemoradiotherapy in eight children who had incompletely resected supratentorial low-grade astrocytoma. PROCEDURE: There were six boys and two girls, aged 4-15 years. Four tumors were in the cerebral hemispheres, one in the hemisphere and thalamus, two in the third ventricle and/or thalamus, and one in the basal ganglia. Partial resection of the tumor was performed in four patients, biopsy in four; the extent of surgery was additionally evaluated with computed tomographic (CT) and/or magnetic resonance imaging (MRI) studies. A tumor dose of 50-56 Gy was delivered postoperatively in 1.8-2.1 Gy daily fractions five times per week. Chemotherapy was intercalated concomitantly in the radiotherapy protocol: cisplatin 20 mg/m2/2 weeks intravenously (IV) and vincristine 1.5 mg/m2/week IV (up to a maximum dose of 2 mg) were planned, starting on day 1 of irradiation. There were one to three cisplatin applications and one to seven vincristine applications. RESULTS: Seven patients are alive 5.5-11.5 years (median, 8 years) after therapy. Six of seven are without evidence of tumor on CT and/or MRI. A residual mass is still visible in one patient, 11.5 years after therapy. He was treated at the age of 4; he is handicapped due to mental retardation and severe neurological impairment. One patient died 5 years after chemoradiotherapy, due to secondary glioblastoma multiforme, without recurrence at the site of the first tumor. Chemotherapy was discontinued in two patients because of severe nausea and vomiting; there was no hematologic or neurologic toxicity. CONCLUSION: In view of the encouraging results, all patients with incompletely resected supratentorial low-grade astrocytomas will be treated as above. PMID- 9950200 TI - Outcomes and prognostic factors of Chinese children with acute lymphoblastic leukemia in Hong Kong: preliminary results. AB - BACKGROUND: The Chinese population is the biggest ethnic group in the world. However, there are few reports on the treatment outcome of childhood acute lymphoblastic leukaemia (ALL) among the Chinese population. PROCEDURE: Sixty-five children with ALL were treated with a modified protocol of the Medical Research Council United Kingdom Acute Lymphoblastic Leukaemia protocol X(MRC UKALL X) at the Prince of Wales Hospital, Hong Kong. Most patients were ethnic Chinese. They were divided into groups A and B, depending on whether their presenting leucocyte count being was less or greater than 50 x 10(9)/l, respectively. Group A patients of received induction, early intensification (week 5), cranial irradiation, and maintenance for 3 years. Group B patients received an additional late intensification (week 20). RESULTS: The median follow-up duration was 6.8 years(range: 3.4-10.1 years). The event-free and overall survival rates of all patients at 7 years were 66% (confidence interval [CI] 53-76) and 75% (CI 63-84), respectively. The event-free survival rates of groups A and B at 7 years were 67% (CI 52-79) and 60% (CI 32-80), respectively (P= 0.39). The overall survival rates of groups A and B at 7 years were 80% (CI 66-89) and 60% (CI 32-80), respectively (P = 0.07). With this treatment protocol, the factors which adversely affected the outcome were age (<2 years and >10 years) and T-cell subtype. Sex, white blood count at diagnosis, and FAB subtypes were not statistically significant prognostic factors. CONCLUSIONS: The treatment outcomes were comparable with those reported from the MRC UKALL X trials. PMID- 9950202 TI - Investigational approaches to the treatment of brain tumors in children. PMID- 9950201 TI - Cytoprotection in the treatment of pediatric cancer: review of current strategies in adults and their application to children. AB - BACKGROUND: The protection of patients from the acute and/or chronic toxicity of antineoplastic therapy has become a major concern of oncology centers around the world. However, most of the effort has been directed toward the adult population, and limited studies have been performed in the group that may gain the most from such strategies, namely, children. PROCEDURES: The MedLine and CancerLit databases were surveyed, and the relevant biomedical literature on cytoprotection during antineoplastic treatment was analyzed. RESULTS: Cytotoxicity from antineoplastic therapy customarily is addressed by altering dosing schedules, a technique that can seriously impact the efficacy of the therapy. Colony stimulating factors have been used posttherapy to stimulate recovery from neutropenia, and various agents have been proposed as pretherapy cytoprotectors. Trials in adults have produced mixed results, and, to date, only amifostine and dexrazoxane have been approved as cytoprotectors for very narrow indications. Few trials have been performed in children, although these patients often can look forward to long-term remission. CONCLUSIONS: To prevent permanent toxicities from antineoplastic therapies that impact long-term pediatric survivors, the experience gained in adults should be extended more aggressively to children, and formal, randomized trials should be performed to determine the type of protection most suitable for the pediatric population. PMID- 9950203 TI - Silhouette. Professor Ya-mei Hu. PMID- 9950205 TI - Tumor markers in retinoblastoma. PMID- 9950204 TI - Synovial sarcoma with t(X:18) chromosomal translocation, cardiac involvement, and peripheral embolus. PMID- 9950206 TI - Detection of minimal residual disease by PCR in childhood T-cell acute lymphoblastic leukemia with TAL1 gene rearrangement: a preliminary report. PMID- 9950207 TI - Fungal infection due to Fusarium (spp) in children with refractory hematologic malignancies. PMID- 9950208 TI - Acute respiratory distress syndrome following resection of a mesenchymal hamartoma of the liver. PMID- 9950209 TI - Osteonecrosis in children treated for acute lymphoblastic leukemia: a magnetic resonance imaging study after treatment. PMID- 9950210 TI - Alkalinization and tumor lysis syndrome. PMID- 9950211 TI - 7th meeting of Experimental Neuro-oncology, March 7, 1998, Gottingen, Germany: introduction. PMID- 9950212 TI - Mammary tumor formation in p53- and BRCA1-deficient mice. AB - The inheritance of a mutant copy of the BRCA1 gene greatly increases a woman's lifetime risk for ovarian and breast cancer. While a homologous gene has been identified in mouse, mice carrying mutations in this gene do not display a detectable increase in tumor formation. To determine whether mutations in p53 might increase the incidence of tumors associated with the loss of BRCA1 function in mice, we have generated mice carrying mutations at both of these loci. We report here that the presence of a mutant Brca1 allele does not alter survival of either p53-/- or p53+/- mice. Although the tumor spectrum was not dramatically altered, an increased incidence of mammary tumors was observed in the Brca1+/-p53 /- mice. Four mammary tumors were seen in the Brca1+/-p53-/- group whereas only one such tumor was seen among the p53-/- control group. In addition, although the presence of a mutant Brca1 allele did not alter the survival rate or the incidence of most tumor types in the p53+/- mice, 5 of the 23 tumors isolated from the Brca1+/-p53+/- mice treated with ionizing radiation were of mammary epithelial origin, and 3 of these had lost expression of the wild-type Brca1 gene. In contrast, no such tumors were observed in the irradiated p53+/- controls. Although the number of mammary tumors observed in these animals is small, these results are suggestive of a role for BRCA1 in mammary tumor formation after exposure to specific DNA damaging agents. PMID- 9950213 TI - Differential responsiveness to autocrine and exogenous transforming growth factor (TGF) beta1 in cells with nonfunctional TGF-beta receptor type III. AB - The two major intestinal epithelial cell lineages are columnar fluid-absorbing cells and mucin-producing goblet cells. High levels of transforming growth factor (TGF) beta1 are found surrounding postmitotic cells in the colonic crypt, suggesting that TGF-beta1 mediates the maturation and growth inhibition of both epithelial cell types. However, we now show that the injection of recombinant TGF beta1 into mice leads to an enrichment of goblet cells, indicating that these normal epithelial cells are resistant to TGF-beta1. In support of this interpretation, each of two independently isolated cell lines modeling normal colon goblet cells was also growth resistant to exogenous TGF-beta1 but made levels of TGF-beta receptor (TbetaR) I, TbetaRII, and TbetaIII mRNA and protein equal to those made by two TGF-beta1-sensitive cell lines. No mutations were found in the alk5 or alk2 forms of TbetaRI or in TbetaRII; these receptors were found on the cell surface, although they could not bind 125I-labeled TGF-beta1. TbetaRIII binds TGF-beta1, concentrates it, and presents it to TbetaRII. The major TbetaRIII form, betaglycan, did not undergo normal posttranslational modification in either of the goblet cell lines and could not bind 125I-labeled TGF-beta1; thus, it was nonfunctional. TGF-beta resistance was overcome by raising TGF-beta1 levels 100-fold, at which point TbetaRII could bind TGF-beta1. Signaling initiated by these higher TGF-beta1 levels was blocked by the expression of dominant negative TbetaRII, demonstrating that TbetaRII and TbetaRI were functional. Cells resistant to exogenous TGF-beta1 maintained functional cell surface TbetaRI and TbetaRII to mediate responses to autocrine TGF-beta1, which controlled the maturation of the adhesion protein integrin beta1. Expression of dominant negative TbetaRII in goblet cells greatly inhibited the conversion of the beta1 integrin from its precursor to its mature form. Thus, in normal intestinal epithelial goblet cells, TbetaRI and TbetaRII can respond to autocrine but not exogenous TGF-beta without the participation of TbetaRIII. Absorptive epithelial cells are growth inhibited by TGF-beta1 both in vivo and in vitro; therefore, the loss of functional TbetaRIIIs on goblet cells allows differential regulation of the two major intestinal epithelial cell types. PMID- 9950214 TI - Two alternatively spliced Meig1 messenger RNA species are differentially expressed in the somatic and in the germ-cell compartments of the testis. AB - Previous studies regarding the transcriptional pattern of the murine Meig1 gene (formally designated meg1) suggested that its transcription is restricted to germ cells at the first meiotic prophase, in both primary spermatocytes and primary oocytes. However, protein analysis revealed that certain forms of the MEIG1 protein exist in testes of early postnatal pups at stages that have no germ cells in the testis, excluding very few primitive type A spermatogonia cells. This suggested that MEIG1 expression is not confined to germ cells. In this study, we show that testicular somatic cells do, indeed, express MEIG1. This is especially evident in Leydig cells, where this protein is highly abundant. We also demonstrate that alternatively spliced mRNAs of Meig1 are differentially transcribed in the germ cell and the somatic compartments of the testis. There is a very low level of somatic transcript, whether labile or transcriptionally regulated, in contrast to the abundant MEIG1 protein in the somatic cells. This implies that the somatic transcript is very efficiently translated and reconfirms that protein levels do not necessarily reflect transcript abundancy. Structural features of the Meig1 transcript that would be expected to inhibit translation are discussed in light of the efficient translation of this RNA species. PMID- 9950215 TI - Deletion of p16INK4A/CDKN2 and p15INK4B in human somatic cell hybrids and hybrid derived tumors. AB - Deletion or epigenetic inactivation of the tumor suppressor gene p16INK4/CDKN2 (p16) has been observed in multiple human tumors. We assayed hybrid cell lines between human diploid fibroblasts and fibrosarcoma cells for p16 allelic status and expression and found that p16 was expressed in the parental diploid fibroblast cell lines used, whereas the parental fibrosarcoma cell line HT1080.6TG exhibited homozygous deletion of p16. Most immortalized hybrid cell lines derived from these parent cell lines, whether tumorigenic or nontumorigenic, exhibited loss of fibroblast-derived p16 alleles. All p16 negative hybrid cell lines also exhibited deletion of p15INK4B (p15). Hybrid cell lines yielded tumors upon s.c. injection into athymic nude mice regardless of p16/p15 status. Tumors derived from six p16/p15-positive hybrid cells, however, revealed deletions of both p16 and p15. When human diploid fibroblasts were fused with A388.6TG squamous cell carcinoma cells, which exhibit aberrant methylation of p16, the resulting hybrids again exhibited deletion of the unmethylated fibroblast-derived p16 alleles. Transfection of both HT1080.6TG and A388.6TG cells with wild-type p16 expression vector resulted in decreased clonogenicity in culture. Although the determinants directing genetic versus epigenetic inactivation of p16 and p15 remain unclear, these results demonstrate that p16 mediated growth suppression could be abrogated by either mechanism in somatic cell hybrids. PMID- 9950216 TI - Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. AB - Netrins, a family of laminin-related secreted proteins, have critical roles in axon guidance and cell migration during development. The deleted in colorectal cancer (DCC) protein has been implicated as a netrin-1 receptor component. The expression and function of netrins in adult tissues remain unknown, and direct interaction of netrin-1 with DCC has not been demonstrated. We cloned the human netrin-1 (NTN1L) gene, mapped it to chromosome 17p12-13, and found that it encodes a 604 amino acid protein with 98% identity to mouse netrin-1 and 50% identity with the Caenorhabditis elegans UNC-6 protein. NTN1L transcripts were detected in essentially all normal adult tissues studied, and markedly reduced or absent NTN1L expression was seen in approximately 50% of brain tumors and neuroblastomas. In one neuroblastoma, missense mutations at highly conserved NTN1L codons were found. Netrin-1 protein could be cross-linked to DCC protein on the cell surface, but it did not immunoprecipitate with DCC in the absence of cross-linking and it failed to bind to a soluble fusion protein containing the entire DCC extracellular domain. Our findings demonstrating NTN1L loss of expression and mutations suggest that NTN1L alterations may contribute to the development of some cancers. Furthermore, the binding of netrin-1 to DCC appears to depend on the presence of a coreceptor or accessory proteins. PMID- 9950217 TI - Differential regulation of peroxisome proliferator activated receptor gamma1 (PPARgamma1) and PPARgamma2 messenger RNA expression in the early stages of adipogenesis. AB - Adipocyte differentiation is driven by the expression and activation of three transcription factor families: the differentially expressed CAAT/enhancer binding proteins (C/EBPs) alpha, beta, and delta; the helix-loop-helix adipocyte differentiation and determination factor-1; and peroxisome proliferator activated receptor gamma (PPARgamma), expressed as two isoforms, PPARgamma1 and the adipocyte-specific PPARgamma2. Overexpression of PPARgamma can induce adipocyte differentiation; therefore, we analyzed the expression of the two PPARgamma isoforms during early stages of differentiation to determine whether one was preferentially induced as an early determining event. Surprisingly, in the first 24 h, a 3-6-fold increase of PPARgamma2 mRNA was observed, whereas PPARgamma1 mRNA remained unchanged. PPARgamma1 was induced 1 day later. Overexpression of C/EBPbeta has also been shown to induce adipocyte differentiation. A C/EBP site was identified only in the human PPARgamma2 promoter. Its deletion blunted the response of PPARgamma2 promoter to cotransfected C/EBPbeta or methylisobutylxanthine treatment. We hypothesize that PPARgamma2 initiates adipocyte differentiation. PMID- 9950218 TI - Retinoic acid-mediated G1-S-phase arrest of normal human mammary epithelial cells is independent of the level of p53 protein expression. AB - Retinoids mediate the normal growth of a variety of epithelial cells and may play an important role in the chemoprevention of breast cancer. Despite the widespread clinical use of retinoids, specific target genes that are regulated by retinoids are relatively poorly characterized. We reported previously that all-trans retinoic acid (ATRA) mediates G1-S-phase arrest in normal human mammary epithelial cells (HMECs). The tumor suppressor gene p53 is thought to be a critical regulator of G1-S-phase arrest mediated by DNA-damaging agents such as chemotherapy and radiation. The role of p53 protein expression in G1-S-phase arrest mediated by the differentiating agent ATRA is unknown. Increased expression of p53 protein is observed in ATRA-treated HMECs at 72 h; however, initiation of G1-S-phase arrest starts at 24 h, suggesting that this observed induction of p53 is a secondary event. Using retroviral-mediated gene transfer, we expressed the E6 protein of the human papillomavirus strain 16 (HPV-16) in HMECs. The HPV-16 E6 protein binds to p53 and targets it for degradation. Western analysis confirmed that HPV-16 E6-transduced HMECs had markedly decreased levels of p53 protein expression. Suppression of cellular p53 levels in HMECs did not alter the sensitivity of HMECs to ATRA-mediated growth arrest. Our studies suggest that ATRA-mediated G1-S-phase arrest is independent of the level of p53 protein expression. We also tested the ability of estrogen and antiestrogens to induce growth arrest in HMECs lacking p53 expression and found no decrease in the sensitivity of these cells to these agents. Our results emphasize the chemotherapeutic potential of ATRA and antiestrogens, particularly for suppressing the growth of tumors lacking functional p53. PMID- 9950220 TI - Scolex morphology of the cestode Silurotaenia siluri (Batsch, 1786) (Proteocephalidae: Gangesiinae), a parasite of European wels (Silurus glanis). AB - The morphology of the scolex of the tapeworm Silurotaenica siluri (Batsch, 1786) (Proteocephalidae: Gangesiinae), a specific parasite of European wels (Silurus glanis L.), was studied using light, scanning (SEM), and transmission electron (TEM) microscopy. The scolex of S. siluri is rather uniform in shape and size; it is globular, and has four prominent, anteriorly directed suckers and a spherical, muscular apical organ corresponding to the rostellum of cyclophyllidean cestodes. The rostellum-like apical organ is armed with five to six irregular rows of small hooklets with a wide, oval basal plate and a short, posteriorly curved blade. The excretory system of the scolex is formed by sinuous secondary canals ending blindly beneath the distal layer of the tegument, not opening outside. The surface of the scolex is covered with filiform microtriches; giant spine-like and blade-like microtriches, incorrectly interpreted as spines or hooklets in previous descriptions of S. siluri, are present on the neck region and posterior margins and internal cavities of the suckers. It is assumed that tegumental spines reported in the scolices of other proteocephalideans (subfamilies Acanthotaeniinae and Gangesiinae, genera Spasskyellina and Nomimoscolex) could indeed be spiniform microtriches. PMID- 9950219 TI - Shc dominant negative disrupts cell cycle progression in both G0-G1 and G2-M of ErbB2-positive breast cancer cells. AB - The Shc protein helps to transmit signals from receptor and cytoplasmic tyrosine kinases to Ras. We have shown that several breast cancer cell lines (MDA-MB-453, BT474, MDA-MB-361, and SKBR3), which overexpress the ErbB2 receptor tyrosine kinase, contain constitutively tyrosine phosphorylated Shc. To investigate the role of Shc in these cells, we transfected them with a Shc-Y317F dominant negative mutant defective in signaling to Ras. The transfectants were unable to form stable colonies, suggesting a critical role for Shc in the proliferation of these cells. In contrast, dominant-negative Shc transfectants of the nontransformed breast epithelial cell line HBL-100 grew normally. Surprisingly, cell cycle analysis of transfected SKBR3 cells suggested that the cells were blocked not only in G0-G1, but also in G2-M. The G2-M block was unexpected because Shc-Y317 is downstream of receptor tyrosine kinases that drive the early events in the cell cycle. Both the G0-G1 and G2-M arrest were rescued by transfection with wild-type Shc or oncogenic Ras 12V. Rescue by Ras suggests that Shc Y317 signals upstream of Ras, and that Shc to Ras effector pathways are involved in G2-M, although confirmation awaits a detailed molecular analysis. Most importantly, this work provides the first evidence for Shc involvement in G2 M. PMID- 9950221 TI - Schistosomal granuloma modulation. I. Schistosoma mansoni worm antigens CAA and CCA prime egg-antigen-induced hepatic granuloma formation. AB - Adult Schistosoma mansoni worms can positively modulate soluble egg antigen (SEA) induced granulomas formed around SEA-coupled beads implanted in the liver. In this study, our aim was to further unravel the immunopathological characteristics of S.mansoni-worm-derived antigens in vivo. (a) Adult worm antigen (AWA)-coupled Sepharose beads, implanted into the liver, induced granulomas, containing numerous eosinophilic granulocytes and elicited marked periparticular fibrosis (composed of interstitial matrix proteins and basement membrane components). (b) Quantitative morphological analysis demonstrated that in naive mice, AWA-induced hepatic granuloma formation peaked in volume 16 days after injection of the beads. An accelerated response against AWA-coupled particles (peak volume at 8 days) was observed in mice carrying a single-sex, male S. mansoni infection. (c) When the granuloma volume induced by SEA-coupled beads in unisexually S. mansoni infected mice was compared to granulomas induced by beads laden with both SEA and AWA in unsensitized mice, no significant differences in granuloma volume were seen, indicating the existence of in vivo egg/worm antigen cross-sensitization. (d) Naive mice, sensitized with the worm antigens circulating anodic antigen (CAA) or circulating cathodic antigen (CCA), mounted a strongly accelerated response towards SEA-coupled beads implanted in the liver. We infer that, in vivo, worm antigens cross-sensitize with egg antigens and have both granulomogenic and fibrogenic characteristics. The S. mansoni soluble worm antigens CCA and CAA prime hepatic egg-antigen-induced granuloma formation possibly through the presence of immunogenic carbohydrates. These mechanisms lead to an accelerated response against SEA. PMID- 9950222 TI - Schistosomal granuloma modulation. II. Specific immunogenic carbohydrates can modulate schistosome-egg-antigen-induced hepatic granuloma formation. AB - To further investigate the factors involved in the modulation of the schistosomal granuloma, mice were primed with immunogenic carbohydrates which were common to soluble egg antigen (SEA) and adult worm antigen. Mice sensitized with LewisX trisaccharide or lacto-N-fucopentaose-III (LNFP-III) displayed an increased cellular response towards SEA-coupled beads implanted in the liver by mesenteric injection, resulting in the formation of larger periparticular granulomas. When animals were sensitized with bovine serum albumin or a structurally related carbohydrate, an accelerated response was not seen. Since LNFP-III is built up of LewisX molecules, and LewisX carbohydrates are common to SEA and worm antigens such as the gut-secreted antigens CCA and CAA (two antigens that could prime egg antigen-induced granuloma formation), this may explain why adult, live Schistosoma mansoni worms positively modulate egg-antigen-induced hepatic granuloma formation in the murine host. These observations provide new insights into the role of carbohydrates in parasite-host immunity and may yield important implications for choosing worm-derived antigens for the development of anti schistosome vaccines. PMID- 9950223 TI - Strain-specific recognition of live Leishmania donovani promastigotes by homologous antiserum raised against a crude membrane fraction of infected macrophages. AB - Surface antigens on Leishmania promastigotes and infected macrophages are obvious targets in immunoprophylaxis for leishmanial infection. We have recently demonstrated that the polyclonal antiserum and monoclonal antibodies generated by homologous immunizations with the crude membranes of parasite-infected cells react effectively with the 'neo-antigenic' determinants on the infected cell surface. In the present study, we investigated the utility of such polyclonal antisera for identifying 'minor' surface components of promastigotes. The reactivity of anti-Leishmania donovani-(strain RMRI68) infected macrophage membrane (anti-IMm) antiserum was compared with that of anti-promastigote (anti Pr) antiserum towards the infected macrophage surface and promastigotes of three Indian strains of L. (donovani, RMRI68, AG83 and DD8. While anti-Pr antiserum showed no reactivity with the infected macrophage surface but reacted strongly with air dried and live promastigotes of all three strains, anti-IMm antiserum reacted with the infected cell surface and, interestingly, specifically recognized live promastigotes of the strain used for infection, i.e., strain RMRI68. The reactivity patterns of the two antisera with the immunodominant components of the L. donovani promastigote surface, i.e., purified LPG-KMP11 complex and gp63 molecules, indicated that unlike anti-Pr antiserum, the specificities in anti-IMm antiserum were mainly directed towards molecules other than the LPG-KMP11 complex and gp63. Antiserum generated in a similar fashion against the macrophage membrane of cells infected in vitro with strain AG83 also contained antibodies specific to strain AG83 promastigotes. The present approach may therefore greatly help in identifying specific antigen(s) important in clinical and epidemiological control of leishmaniasis. PMID- 9950224 TI - RNA-dependent RNA polymerase activity associated with virus-like dsRNA in Eimeria maxima and E. necatrix of the domestic fowl. AB - RNA-dependent RNA polymerase (RDRP) activity was identified in lysates of Eimeria maxima sporozoites and E. necatrix sporozoites and merozoites. Pretreatment of cell lysates with DNase I, RNase A, proteinase K and actinomycin D prior to RDRP assay was employed to characterize RDRP activity. DNase I and actinomycin D had little effect, while proteinase K abolished RDRP activity in both species. RNase A at a concentration of 1 mg/ml also reduced the polymerase activity in E. maxima and E. necatrix sporozoite lysates to 2% and 0%, respectively. Gel electrophoresis of RDRP products revealed that while most migrated at sizes less than 3 kb, a proportion of labelled products of E. necatrix and E. maxima also migrated to the sizes of their respective putative viral genomes. The RDRP products of E. necatrix were shown to be single-stranded by digestion with RNase in both low- and high-salt solutions and by methylmercuric hydroxide treatment. Moreover, the RDRP products of E. necatrix only hybridized to the 5.6-kb dsRNA of E. necatrix but not to the 4.5-kb dsRNAs of E. necatrix or E. maxima. PMID- 9950225 TI - Evaluation of the recovery of waterborne Giardia cysts by freshwater clams and cyst detection in clam tissue. AB - The Asian freshwater clam, Corbicula fluminea, inhabits environments recognized to be contaminated with waterborne Giardia cysts. Sixty-four tissue samples of Giardia-free clams were spiked with various numbers of Giardia duodenalis cysts within the range of 50-700 cysts. Regression analysis showed that paired numbers of spiked (x) versus recovered (y) cysts regressed significantly (P < 0.01) according to the equation y = 42.57 +/- 1.81x (+/- 64.3). The cyst detection threshold was 43 cysts/clam, the coefficient of determination was 77%, and the overall sensitivity of cyst detection was 42.9%. All 20 values of cyst numbers in clam tissue samples that were processed blind were located within the 95% prediction limits of the linear regression equation. The cyst retention rate of 160 clams kept in an aquarium with 38 l of water spiked with 1.00 x 10(5) G. duodenalis cysts was approximately 1.3 x 10(3) cysts/clam. No waterborne cysts were detected by the membrane filtration method 90 min after spiking the aquarium water. G. duodenalis cysts were detected in clam tissue up to 3 weeks post exposure. Filtration of water by clams substantially depleted the aquarium water of its particulate matter. The sampling program demonstrated that the population of 160 clams examined during the study could be accurately assessed for exposure to waterborne Giardia cysts by random sampling of 86 (54%) clams. The results indicate that C. fluminea clams can be used for biological monitoring of contamination with Giardia. PMID- 9950226 TI - Reappraisal of vesicular types in the syncytial tegument of the Echinococcus granulosus protoscolex. AB - The structure, abundance, and distribution of tegumentary vesicles was compared among Echinococcus granulosus protoscoleces that had been prepared for electron microscopy using four processing schedules: a conventional method, alternative fixations using uranyl acetate or osmium tetroxide-potassium ferricyanide, and a freeze-substitution method. Four morphologically distinct types of vesicles were found in the somal region. The morphology of the first form, with moderately electron-opaque contents, and the second form, with similar size and shape but containing an electron-opaque core, varied little among the preparation methods. Two additional forms of vesicles, with characteristic intensely electron-opaque contents, were revealed only after freeze-substitution. These elongate vesicles were also found in the scolex tegument where they were most conspicuous, and appeared markedly increased in number after freeze-substitution. Large, spherical vesicles with an electron-lucent core embedded in a dense matrix of fibrillar strands were the dominant vesicle forms in the scolex region after all methods of preparation. Fixation by osmium tetroxide-potassium ferricyanide revealed the presence of spherical vesicles with amorphous electron-opaque contents and a few inclusions. This form of vesicle was also observed after freeze-substitution, but the inclusions in the vesicular lumen were more numerous. The variation in the distribution of vesicle forms among the body regions strongly implies a variety of vesicle functions. In addition, our observations suggest that comparative studies of different fixative methods are necessary to demonstrate the detailed vesicular morphology of the tegument of E. granulosus and other cestodes. PMID- 9950227 TI - Characterization of a Plasmodium chabaudi gene encoding a protein with glutamate rich tandem repeats. AB - Several highly antigenic proteins containing tandem repeats rich in glutamic acid residues have been described in Plasmodium falciparum. However, relatively little information is available about analogous genes in rodent parasites. This report describes a 4.2-kb genomic DNA fragment from P. chabaudi with a deduced amino acid sequence that is predominantly glutamate-rich tandem repeats. Several different monoclonal antibodies raised against a 93-kDa P. chabaudi protein, which does not correspond to the cloned DNA fragment, recognize a recombinant protein expressed from the 4.2-kb DNA fragment. The only sequence similarities between these two genes are tandem repeats with a predominance of glutamate pairs followed by a hydrophobic residue. This repetitious-sequence motif may be the basis for the observed cross-reactivity. A similar motif has been demonstrated to be the basis for antibody cross-reactivity between glutamate-rich proteins of P. falciparum. The expression of multiple glutamate-rich proteins with cross reacting epitopes may be a general phenomenon in Plasmodium species. PMID- 9950228 TI - Trichinella spiralis: proteinases in the larvae. AB - Under in vitro conditions, muscle larvae of Trichinella spiralis secreted minute amounts of a cysteine proteinase into the outer environment from the stichosome. The proteinase hydrolyzed azocoll at pH 5.0 but not a number of synthetic N blocked and N-unsubstituted proteinase substrates at this pH. The reducing compound dithioerythritol enhanced the enzyme activity, but the thiol-blocking reagent sodium-p-hydroxymercuribenzoate (0.1 mM) was without effect. Phenylmethylsulfonyl fluoride (PMSF) (2 mM) and leupeptin (100 mM) produced partial and complete inhibition, respectively, whereas soybean trypsin inhibitor, pepstatin A, and 1,10-phenanthroline were non-inhibitory. Calcium (1 mM) produced a slight decrease in the activity that was reversed by 1 mM EGTA. Although multiple proteinase activities were detected histochemically in the somatic muscles, stichosome, midgut, and genital primordium of the muscle larvae, none of these enzymes appeared to be the one secreted. Several histochemically demonstrable proteinases were also found in the cells of 48- to 72-h-old juveniles of the parasite. One was localized in the esophageal lumen and at or around the anterior esophagus of the larvae, where developing stichocytes are believed to occur. The proteinase hydrolyzed N-acetyl-L-methionine-L-naphthyl ester and was sensitive to the metal cation-complexing compound EGTA as well as to PMSF, an inhibitor of serine proteinases. PMID- 9950229 TI - Trichinella spiralis: in vitro cytotoxicity of peritoneal cells against synchronous newborn larvae of different age. AB - Two different immune sera obtained from mice infected with muscle larvae (ML) of Trichinella spiralis (oral infection) or injected with 20-h-old newborn larvae (NBL) via retro-orbital venous plexus (intraocular injection) were compared in antibody-dependent cellular cytotoxicity test. Four synchronous stages of NBL, 0 2 h old, 22 24 h old, 46-48 h old and 6 days old (sNBL) were used to study susceptibility of larvae to the cytotoxic reaction of peritoneal cells. Peritoneal cells adhered to and destroyed sNBL of T. spiralis only in the presence of both immune sera. Living sNBL, living sNBL covered by peritoneal cells and dead sNBL were observed in all experimental groups. The lowest percentage of dead sNBL was detected in the 22- to 24-h-old groups. A dramatic increase in mortality was observed in older groups. A greater susceptibility of sNBL to serum obtained from mice infected per os with ML was observed. Serum obtained after oral infection showed higher levels of IgG1 isotype specific to ML than serum obtained after ocular injection. PMID- 9950230 TI - Proteolytic activity of the Gymnorhynchus gigas plerocercoid: purification and properties of a collagenase from the crude extract. AB - The present report demonstrates that the Gymnorhynchus gigas plerocercoid possesses various types of endo- and exoproteases with activity against general (azocoll, azocasein, and azoalbumin) and specific substrates (elastin, keratin, collagen, hemoglobin, fibrinogen, plasma, and immunoglobulin G). The activity against collagen is principally due to a 24-kDa collagenase with an isoelectric point of 7.5 and without isoforms or sugar residues. Moreover, its high degree of proteolytic activity against collagen under conditions similars to those encountered by the parasite in its hosts (pH and temperature) and its similarity to metallo- and cysteine proteases (the principal protease types implicated in degradation of tissues) suggests the importance of this molecule as a lytic enzyme principally implicated in penetration processes across the teleost muscle or/and into the gastrointestinal system of elasmobranch fishes as well as in molting processes. PMID- 9950231 TI - Immunogenicity of three oocyst extracts of Cryptosporidium baileyi in experimentally infected chickens. AB - The immunogenic properties of water-soluble and detergent-extracted components of Cryptosporidium baileyi oocysts were studied. Oocyst cytosol antigen (OCA) containing hydrophilic proteins was obtained by freeze-thaw cycles in liquid nitrogen. This was followed by Triton X-114 extraction of remaining oocyst fragments to dissolve membrane-bound proteins (TRE). The remainder of the pellet was solubilized with sodium dodecyl sulfate and treated with 2-mercaptoethanol to reduce disulfide-linked oocyst wall proteins (BME). The immune recognition of these three extracts was evaluated during the course of experimental cryptosporidiosis in chickens using ELISA, immunoblotting, and the lymphocyte stimulation test (LST). Four groups of chickens were infected at various times with different doses of C. baileyi and one group with the mammalian parasite C. parvum. Analysis of the data revealed that OCA proteins are well recognized by serum antibodies during the infection and to a limited extent by sera from chickens infected with C. parvum. Humoral responses of chicken groups to this antigen did not correlate well with the length of patency in contrast with its cellular recognition in LST. TRE gave lower values than OCA in both ELISA and LST, though it was still specifically recognized by samples from C. baileyi infected chickens. Antibodies reacted aspecifically with BME, since only samples of birds which were immunocompetent at the time of their infection were able to recognize this extract as antigen. Immunoblotting revealed more specific components in OCA than in TRE or BME. PMID- 9950232 TI - Protection of hamsters from amebic liver abscess formation by a monoclonal antibody to a 150-kDa surface lectin of Entamoeba histolytica. AB - We examined the effects of passive immunization with a monoclonal antibody (EH3015) that recognizes a 150-kDa surface lectin of Entamoeba histolytica on amebic liver-abscess formation in hamsters. The hamsters were inoculated i.p with 0.1, 1.0, or 10 mg of EH3015 at 24 h prior to an intrahepatic challenge with 10(5) trophozoites of E. histolytica. In hamsters treated with 1.0 and 10 mg of EH3015 the incidence of liver abscesses was significantly reduced. These results demonstrate that monoclonal antibody EH3015 can prevent the development of amebic liver abscesses and that the 150-kDa lectin may be a protective antigen on the surface of E. histolytica. PMID- 9950233 TI - Role of dietary fat in the causation of breast cancer: point. PMID- 9950234 TI - Role of dietary fat in the causation of breast cancer: counterpoint. PMID- 9950235 TI - Meat consumption, genetic susceptibility, and colon cancer risk: a United States multicenter case-control study. AB - Meat consumption may especially increase risk of colon cancer when the meat is prepared at high temperatures and consumed by subjects with an inherited susceptibility to well-done meat. In this United States case-control study, the association between meat consumption, genetic susceptibility, and colon cancer risk was studied. Meat consumption data were available from a detailed diet history questionnaire and from questions about methods of preparation. Molecular variants in the carcinogen-metabolizing genes NAT2 and GSTM1 were determined in DNA extracted from WBCs. A total of 1542 cases and 1860 population-based controls were included in these analyses. The amount of red and white meat consumed was not associated with overall colon cancer risk. Processed meat consumption was weakly positively associated with colon cancer risk in men only (odds ratio for highest versus lowest quintile of intake = 1.4, 95% confidence interval = 1.0 1.9). The frequency of fried, broiled, baked, or barbecued meat, use of drippings, and doneness of meat were not significantly associated with risk. The Mutagen Index, as an estimate for exposure to mutagenic or carcinogenic substances, was slightly positively associated with colon cancer risk in men (odds ratio = 1.3, 95% confidence interval = 1.0-1.7). No significant associations with colon cancer risk were observed for different NAT2 and GSTM1 gene variants. The observed associations with processed meat and the Mutagen Index were strongest for those with the intermediate or rapid NAT2 acetylator phenotype. Associations were not markedly influenced by lack of the GSTM1 gene. This study provides little support for an association between meat consumption and colon cancer risk but does provide some, albeit not strong, evidence for a modifying effect of molecular variants of the NAT2 gene. PMID- 9950236 TI - Dietary factors and risks for prostate cancer among blacks and whites in the United States. AB - Prostate cancer is the most common malignancy in men in the United States, with substantially higher rates among American blacks than whites. We carried out a population-based case-control study in three geographic areas of the United States to evaluate the reasons for the racial disparity in incidence rates. A total of 932 men (449 black men and 483 white men) who had been newly diagnosed with pathologically confirmed prostate cancer and 1201 controls (543 black men and 658 white men) were interviewed in person to elicit information on potential risk factors. This report evaluates the impact of dietary factors, particularly the consumption of animal products and animal fat, on the risk of prostate cancer among blacks and whites in the United States. Increased consumption (grams/day) of foods high in animal fat was linked to prostate cancer (independent of intake of other calories) among American blacks [by quartile of intake, odds ratio (OR) = 1.0 (referent), 1.5, 2.1, and 2.0; Ptrend = 0.007], but not among American whites [by quartile of intake, OR = 1.0 (referent), 1.6, 1.5, and 1.1; Ptrend = 0.90]. However, risks for advanced prostate cancer were higher with greater intake of foods high in animal fat among blacks [by quartile of intake, OR = 1.0 (referent), 2.2, 4.2, and 3.1; Ptrend = 0.006] and whites [by quartile of intake, OR = 1.0 (referent), 2.2, 2.6, and 2.4; Ptrend = 0.02]. Increased intake of animal fat as a proportion of total caloric intake also showed positive but weaker associations with advanced prostate cancer among blacks (Ptrend = 0.13) and whites (Ptrend = 0.08). No clear associations were found with vitamin A, calcium, or specific lycopene-rich foods. The study linked greater consumption of fat from animal sources to increased risk for prostate cancer among American blacks and to advanced prostate cancer among American blacks and whites. A reduction of fat from animal sources in the diet could lead to decreased incidence and mortality rates for prostate cancer, particularly among American blacks. PMID- 9950237 TI - Urinary excretion of isoflavonoids and the risk of breast cancer. AB - Isoflavonoids are a group of biologically active phytochemicals that humans are exposed to mainly through soy food intake. Because of the similar chemical structure of these compounds and estradiol, it has been hypothesized that isoflavonoids may be related to the risk of breast cancer. Overnight urine samples from 60 incident breast cancer cases and their individually matched controls were assayed for urinary excretion rates of five major isoflavonoids (daidzein, genistein, glycitein, equol, and O-desmethylangolensin) and total phenols. These subjects were from a large population-based case-control study conducted in Shanghai, and urine samples from breast cancer cases were collected before any cancer therapy to minimize the potential influence of the disease and its sequelae on study results. Urinary excretion of total phenols and all individual isoflavonoids, particularly glycitein, was substantially lower in breast cancer cases than controls. For total isoflavonoids, the mean excretion was 13.95 nmol/mg creatinine (SD, 20.76 nmol/mg creatinine) for cases and 19.52 nmol/mg creatinine (SD, 25.36 nmol/mg creatinine) for controls (P for difference = 0.04). The case-control difference was more evident when median levels of these compounds were compared, with the median excretion of all major isoflavonoids being 50-65% lower in cases than in controls. Individuals in the highest tertile of daidzein, glycitein, and total isoflavonoids had about half the cancer risk of those in the lowest tertile. The adjusted odds ratio for breast cancer was 0.14 (95% confidence interval, 0.02-0.88) for women whose urinary excretion of both phenol and total isoflavonoids was in the upper 50% compared with those in the lower 50%. The results from this study support the hypothesis that a high intake of soy foods may reduce the risk of breast cancer. PMID- 9950238 TI - Polychlorinated biphenyls, cytochrome P4501A1 polymorphism, and postmenopausal breast cancer risk. AB - In experimental systems, polychlorinated biphenyls (PCBs) induce cytochrome P4501A1 (CYP1A1), which is involved in metabolism of steroid hormones and polycyclic aromatic hydrocarbons in humans. A genetic polymorphism coding for a valine to isoleucine substitution in exon 7 has been associated with lung cancer risk in Japanese populations. In a previous study, we found no association between CYP1A1 genotype and breast cancer risk. However, we were interested in determining whether genotype would relate to risk when PCB body burden was taken into account. In a subset of a case-control study in western New York, 154 postmenopausal women with incident, primary, histologically confirmed postmenopausal breast cancer and 192 community controls were interviewed and underwent phlebotomy. Serum levels of 56 PCB peaks were determined by high resolution gas chromatography with electron capture. PCR-RFLP analyses of the CYP1A1 polymorphism were performed. Unconditional logistic regression was used to compute adjusted odds ratios and 95% confidence intervals. Among women with serum PCB levels above the median of the distribution in the control group, there was increased risk of breast cancer associated with the presence of at least one valine allele, compared with women who were homozygous for the isoleucine alleles (odds ratio, 2.93; 95% confidence interval, 1.17-7.36). Among women with low PCB body burden, no association between CYP1A1 genotype and breast cancer risk was observed. Adjustment for serum lipids and body mass index did not affect the magnitude of the observed associations. PCB body burden may modify the effect of the polymorphism on postmenopausal breast cancer risk through increased CYP1A1 enzyme induction or by activation by specific PCB congeners. These results should be considered preliminary, pending replication by other studies. PMID- 9950239 TI - Independent and joint effects of family history and lifestyle on colorectal cancer risk: implications for prevention. AB - It has been suggested that, for a substantial proportion of "sporadic" colorectal cancers (CRCs), inheritance determines individual susceptibility and that lifestyle determines which susceptible individuals express cancer. Because the genetic basis of this inherited susceptibility remains undefined, we used family history of the disease as a proxy for a genetic predisposition to examine its interactions with a variety of lifestyle factors in a large population-based case control study of CRC. The subjects were 698 male and 494 female Japanese, Caucasian, Filipino, Hawaiian, and Chinese patients diagnosed with CRC in Hawaii during 1987-1991 and 1192 population controls matched to cases on age, sex, and ethnicity. Fourteen percent of the cases and 6% of the controls reported a family history of CRC among parents or siblings. After adjusting for other covariates, significant interactions with family history were found for beef and ethanol intakes in males (P = 0.03). Relative to men without a family history and whose intake fell in the lower third, odds ratios (ORs) for CRC for men with a family history and in the upper tertile of intake were 10.8 [95% confidence interval (CI), 4.2-27.6] and 7.5 (CI, 3.1-18.2) for beef and ethanol, respectively. The corresponding ORs for men without a family history and in the upper tertile were 1.5 (CI, 1.0-2.3) and 1.4 (CI, 1.0-1.9), respectively. No interactions were detected in women. Using a summary measure of lifestyle, we found that family history was not associated with CRC among men who were at the lower-risk tertile for all of the lifestyle risk factors. In contrast, the OR for men with a family history and at the higher-risk tertile for all of the lifestyle variables was 11.7 (CI, 5.8-23.9). In the absence of a family history, this OR was 4.8 (CI, 3.2 7.2). These data suggest that family history increases the risk of sporadic CRC in men mainly through its interaction with lifestyle exposures, primarily a high beef and ethanol intake, and are consistent with recent reports of effect modifications of dietary associations by metabolic genes. Computation of population attributable risks also suggested that a comprehensive reduction in exposure to lifestyle risk factors--and more specifically to ethanol and beef for individuals with a familial predisposition for the disease--may have a large beneficial effect on CRC incidence. PMID- 9950240 TI - Family history and prostate cancer risk in a population-based cohort of Iowa men. AB - A family history of prostate cancer has been associated with prostate cancer risk in most prior studies, and more limited data suggest that a family history of breast cancer may also be important; however, there are no data from a population based cohort study of prostate cancer incidence that adjusts for major confounders. We conducted follow-up through 1995 on 1557 men, ages 40-86 years, who were randomly selected (81% response rate) as cancer-free controls for a population-based case-control study conducted in Iowa from 1987-1989. Family history of cancer in parents and siblings was obtained using a mailed questionnaire. Incident cancers and deaths were ascertained through linkages to state and national databases; 101 incident cases of prostate cancer were identified. At baseline, 4.6% of the cohort reported a family history of prostate cancer in a brother or father, and this was positively associated with prostate cancer risk after adjustment for age [relative risk (RR) = 3.2; 95% confidence interval (CI), 1.8-5.7] or after multivariate adjustment for age, alcohol, and dietary factors (RR = 3.7; 95% CI, 1.9-7.2). Risk was greater if a brother had prostate cancer (RR = 4.5; 95% CI, 2.1-9.7) than if a father had prostate cancer (RR = 2.3; 95% CI, 1.0-5.3). Also at baseline, 9.6% of the cohort had a family history of breast and/or ovarian cancer in a mother or sister, and this was positively associated with prostate cancer risk (age-adjusted RR = 1.7; 95% CI, 1.0-3.0; multivariate RR = 1.7; 95% CI, 0.9-3.2). Men with a family history of both prostate and breast/ovarian cancer were also at increased risk of prostate cancer (RR = 5.8; 95% CI, 2.4-14). There was no association with a family history of colon cancer. Exclusion of well-differentiated, localized tumors did not alter these findings. These data from an incidence study confirm that a family history of prostate cancer is a strong prostate cancer risk factor after adjustment for dietary and other risk factors, and suggest that selection and recall bias have not had an important influence on most case-control study results. These data also support the idea that a family history of breast cancer may also be a prostate cancer risk factor. PMID- 9950241 TI - Presentation with multiple cutaneous basal cell carcinomas: association of glutathione S-transferase and cytochrome P450 genotypes with clinical phenotype. AB - We previously reported associations between numbers of basal cell carcinomas (BCCs) and glutathione S-transferase (GSTM1 and GSTT1) and cytochrome P450 (CYP2D6) genotypes. Thus, although GSTM1 AB is protective, GSTM1 null, GSTT1 null, and CYP2D6 EM are associated with increased numbers of lesions. Here, we examine the hypothesis that these genotypes are associated with high-risk subgroups. The subgroup studied comprised 119 patients with more than one previously unidentified BCC at first or later presentations [multiple presentation phenotype (MPP)]. These patients were part of a group of 773 BCC patients that also included 567 patients with one BCC and 87 patients with only one lesion at each presentation [single presentation phenotype (SPP)] but who developed multiple BCCs. The number of tumors in the MPP was significantly greater than that in the SPP groups. In the MPP but not SPP patients, GSTM1 AB, GSTT1 null, and CYP2D6 EM were significantly associated with BCC numbers, suggesting that previously observed associations reflect the influence of these genes only in the MPP cases. There was no evidence that MPP patients had received more UV exposure. We also determined whether the increased numbers of BCC in the MPP cases reflects an association with the truncal tumor phenotype. The values of the rate ratios indicated that the MPP is a marker for the risk of many BCCs, although the combination of MPP and a truncal tumor is a higher-risk phenotype. The data demonstrate the heterogeneity in BCC patients, which reflects differences in genetic factors that determine skin response to UV. PMID- 9950242 TI - Colorectal adenomatous and hyperplastic polyps: smoking and N-acetyltransferase 2 polymorphisms. AB - Arylamine N-acetyltransferase 2 (NAT2) is involved in both the detoxification and bioactivation of carcinogenic arylamines and other mutagens. This enzyme is polymorphic, and the fast and slow phenotypes are thought to be risk factors for colon and bladder cancer, respectively. Here, we report on a case-control study of adenomatous and hyperplastic polyps, with particular attention to tobacco smoking, a known risk factor for adenomas, and polymorphisms of NAT2. All participants underwent complete colonoscopy and were subsequently divided into case and control groups on the basis of pathology. Cases were diagnosed with confirmed adenomas (n = 527) or hyperplastic polyps (n = 200); controls (n = 633) had no history of colonic neoplasia and no polyps at colonoscopy. NAT2 genotype was determined using an oligonucleotide ligation assay and fast, intermediate, or slow phenotype imputed. Multivariate-adjusted odds ratios (ORs) and 95% confidence intervals were computed using logistic regression adjusting for age, sex, nonsteroidal anti-inflammatory drug use, and hormone replacement therapy use. Smoking was associated with an increased risk of adenomas [current versus never smoking OR = 2.0 (95% confidence interval, 1.4-2.9)] and hyperplastic polyps [current versus never smoking OR = 4.1 (2.6-6.5)]. NAT2 status among adenomatous polyp patients and hyperplastic polyp patients, respectively, showed ORs of 1.1 (0.8-1.4) and 1.2 (0.8-1.6; intermediate versus slow) and 1.1 (0.6 1.9) and 0.9 (0.4-1.9; fast versus slow). There were no differences in risk when adenoma patients were stratified on multiplicity, size, or histopathological subtype of polyps. Never-smokers showed no variation in risk across acetylator status for either species of polyp, whereas current smokers showed ORs of 2.0 (1.2-3.2) and 2.3 (1.4-3.9) for adenomas and 3.9 (2.1-7.1) and 4.9 (2.6-9.4) for hyperplastic polyps for slow and intermediate/fast NAT2, respectively, compared with slow-NAT2 never-smokers. Risks of both multiple [OR = 4.3 (2.1-8.8)] and large [OR = 3.8 (1.9-7.5)] adenomas were somewhat elevated in current smokers with an intermediate/fast phenotype compared with smokers with a slow NAT2 phenotype, but the interaction was not statistically significant. Risk of hyperplastic polyps and adenomatous polyps is strongly related to smoking. There is little suggestion of interaction between NAT2 status and smoking and no relationship with NAT2 genotype alone. PMID- 9950243 TI - Polymorphisms in the DNA repair gene XPD: correlations with risk and age at onset of basal cell carcinoma. AB - The XPD protein has a dual function, both in nucleotide excision repair and in basal transcription. We have studied the role of two nucleotide substitutions in the XPD gene, one in exon 23 leading to an amino acid substitution (Lys751Gln) and one silent in exon 6 in relation to basal cell carcinoma (BCC). Both are two allele polymorphisms, with the nucleobases A and C at the given positions. We genotyped psoriasis patients with and without BCC and nonpsoriatic persons with and without BCC (4 x 20 persons). The choice to study psoriasis patients was motivated by their high genotoxic exposure via treatment and their high relative rate of early BCC. Subjects carrying two A alleles (AA genotype) in exon 23 were at 4.3-fold higher risk of BCC than subjects with two C alleles (95% CI, 0.79 23.57). In addition, the mean age at first skin tumor for BCC cases with the AA genotype was significantly lower than the mean age for BCC cases with the AC or CC genotype (P = 0.012). Thus, the variant C-allele of exon 23 may be protective. The exon 6 genotype was associated with the risk of BCC among the psoriasis patients; psoriatics carrying two A alleles in exon 6 were at 5.3-fold higher risk of BCC than psoriatics with two C alleles (95% CI, 0.78-36.31). For the psoriatics, the mean age at onset of BCC for cases with the AA genotype was marginally lower than the mean age for cases with genotype AC or CC (P = 0.060). Our results raise the possibility that the polymorphisms in the XPD gene may be contributing factors in the risk of BCC development. They are, therefore, important candidates for future studies in susceptibility to cancer. PMID- 9950244 TI - Human salivary tea catechin levels and catechin esterase activities: implication in human cancer prevention studies. AB - Because of the possible application of tea in the prevention of oral and esophageal cancers, the salivary levels of tea catechins were determined in six human volunteers after drinking tea. Saliva samples were collected after thoroughly rinsing the mouth with water. After drinking green tea preparations equivalent to two to three cups of tea, peak saliva levels of (-) epigallocatechin (EGC; 11.7-43.9 microg/ml), EGC-3-gallate (EGCG; 4.8-22 microg/ml), and (-)-epicatechin (EC; 1.8-7.5 microg/ml) were observed after a few minutes. These levels were 2 orders of magnitude higher than those in the plasma. The elimination half-life (t(1/2)) of the salivary catechins was 10-20 min, much shorter than that of the plasma. Holding a tea solution in the mouth for a few minutes without swallowing produced even higher salivary catechin levels, but taking tea solids in capsules resulted in no detectable salivary catechin level. Holding an EGCG solution in the mouth resulted in EGCG and EGC in the saliva and, subsequently, EGC in the urine. The results suggest that EGCG was converted to EGC in the oral cavity, and both catechins were absorbed through the oral mucosa. A catechin esterase activity that converts EGCG to EGC was found in the saliva. The enzyme was likely of human origin, but the activity was not inhibited by common human esterase inhibitor. The present results suggest that slowly drinking tea is a very effective way of delivering rather high concentrations of catechins to the oral cavity and then the esophagus. PMID- 9950245 TI - Evaluation of polycyclic aromatic hydrocarbon-DNA adducts in exfoliated oral cells by an immunohistochemical assay. AB - Polycyclic aromatic hydrocarbon-DNA adducts were evaluated in oral cells from 98 healthy volunteers by an immunohistochemical method using a specific antiserum against benzo(a)pyrene-DNA adducts revealed by the immunoperoxidase reaction. Mean adduct content, determined as relative staining intensity by absorbance image analyzer, was significantly higher in the cells from tobacco smokers compared with nonsmokers (330 +/- 98, n = 33 versus 286 +/- 83, n = 64, respectively) with a P = 0.013 obtained by two-sample t test with equal variances. We found that in the smoker group, the PAH-DNA adduct content increases with the number of cigarettes. Thus, the relative staining intensity was 305 +/- 105 in the group smoking 1-10 cigarettes/day (n = 16), 347 +/- 77 in the 11-20 group (n = 14), and 386 +/- 112 in the group smoking more than 20 cigarettes/day (n = 3; P = 0.03 by nonparametric test for trend). No significant association was detected between PAH-DNA adducts in oral cells and variables such as residential area, oral infections, alcohol or vitamin intake, grilled food consumption, and professional activity. This work confirms and extends previous data suggesting that this immunohistochemical method might be used as a valuable dosimeter of genotoxic damage in a carcinogen-exposed population, although further studies are needed to verify the applicability of the test in high-risk populations other than smokers. PMID- 9950246 TI - Is HIV infection a cofactor for cervical squamous cell neoplasia? AB - The objective of this study was to test the hypothesis that HIV interacts with human papilloma virus (HPV) to increase the odds of cervical neoplasia. The study design was a meta-analysis using data pooled from published sources. Studies published between January 1986 and March 1998 were eligible for inclusion if they included data on neoplasia (cytology-based), HIV (defined by laboratory and/or standard clinical criteria), and HPV (assessed by PCR, Southern blot, dot-blot hybridization, or cytology of an otherwise well designed study) among nonpregnant women. Blinded data abstraction was performed independently by the investigators. There were 15 studies that were eligible and presented data in a format that could be abstracted for analysis. Data were pooled using a Mantel-Haenszel summary odds ratio (OR); generalized estimation regression equations were used to examine independent effects of HIV and HPV. Overall, based on the Mantel-Haenszel ORs, there was a strong overall association between HPV and neoplasia [OR, 8.1; 95% confidence interval (CI), 6.5-10.1]. Stratifying by HIV status, HIV-positive women had higher odds of disease (OR, 8.8; 95% CI, 6.3-12.5) than HIV-negative women (OR, 5.0; 95% CI, 3.7-6.8). In the regression model, there was an interaction between HPV and HIV (P = 0.01); immunosuppression also tended to predict neoplasia (P = 0.058). HIV seems to be a cofactor in the association between HPV and cervical neoplasia; this effect may vary by level of immune function. These speculations are biologically plausible. Additional data from large, well designed studies are needed to confirm these hypotheses. PMID- 9950247 TI - An international evaluation of the cancer preventive potential of vitamin A. AB - The IARC convened a Working Group of experts in May 1998 to evaluate the cancer preventive potential of vitamin A and to compile the third volume of the IARC Handbooks of Cancer Prevention. The handbook is intended to provide a comprehensive review of the relevant information in the published scientific literature through April 1998 on the role of vitamin A in cancer prevention. The focus of this critical review and commentary is on retinol and the retinyl esters. Much of the scientific literature in this field overlaps with studies involving vitamin A metabolites, vitamin A precursors, and studies of total dietary vitamin A (which is a combination of preformed vitamin A and its precursors), so work from this wide range of research is included in this review when it is deemed relevant to our understanding of the effects of retinol or retinyl esters on cancer development. The observed effects of preformed vitamin A on cell and organ culture, on animal models, in dietary observational epidemiological studies, and in human intervention studies was reviewed in the meeting. In summary, there is little evidence that vitamin A intake has any substantial cancer-preventive effects. PMID- 9950248 TI - Correspondence re: S. D. Stellman et al., relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York. Cancer Epidemiol. Biomark. Prev., 7: 489-496, 1998. PMID- 9950249 TI - Oral lesions in children with perinatally acquired human immunodeficiency virus infection. AB - Fifteen vertically HIV-infected children aged between 2 and 12 years were followed up for 1 year, weekly to monthly, to study the incidence of oral lesions. At the time of first examination, oral candidiasis (OC) was observed in nine children. Seven children presented with the erythematous type only and two with pseudomembranous oral candidiasis. Four cases of cheilitis were seen in association with the erythematous forms of oral candidiasis. One erythematous candidiasis progressed to pseudomembranous form. A second case of erythematous OC, after multiple recurrences in the form of erythematous OC, recurred as pseudomembranous OC. Another case of erythematous OC and one of pseudomembranous OC presented after multiple recurrences as a persistent, adherent pseudomembranous OC. An orofacial herpes-zoster infection, a hairy leukoplakia and a necrotic lingual ulcer were observed as second lesions and in association with oral candidiasis in three children. Erythematous oral candidiasis was the most frequent oral HIV-related lesion, was observed in different stages of HIV infection, and in some cases progressed to pseudomembranous candidiasis. A different, selectively resistant, Candida clone was isolated in three cases of recurrent candidiasis. PMID- 9950250 TI - Immunohistochemical expression of p53, MDM2, Ki-67 and PCNA in central giant cell granuloma and giant cell tumor. AB - Central giant cell granuloma (CGCG) is a reactive bone lesion that occurs mainly in the jaws. The giant cell tumour (GCT) is a benign locally aggressive neoplasm located near the articular end of tubular bones. Both lesions are characterised histologically by multinucleated giant cells in a background of ovoid to spindle shaped mesenchymal cells. There is a basic question whether both lesions are separate entities or variants of the same disease. The study of cell cycle associated proteins may give insights into clarifying such question. The expression of these proteins is also important to determine the cell cycle regulation in both tumours. The purpose of this study was to evaluate the immunohistochemical expression of p53, MDM2, Ki-67 and PCNA in CGCG and GCT. The results demonstrated that, despite the lack of p53 immunoreactivity, all the samples showed wide expression of MDM2. The percentage of Ki-67- and PCNA positive cells in CGCG was statistically higher than that of GCT Our findings show that CGCG has a higher proliferative activity compared with that of the GCT. Our results also suggest that p53 inactivation by MDM2 expression may be involved in the pathogenesis of giant cell lesions of the jaws and long bones. PMID- 9950251 TI - Deficiency in collagen and fibronectin phagocytosis by human buccal mucosa fibroblasts in vitro as a possible mechanism for oral submucous fibrosis. AB - Oral submucous fibrosis (OSF), a chronic oral mucosal condition commonly found in south Asians, is a disorder characterized by a quantitative as well as a qualitative alteration of collagen deposition within the subepithelial layer of the oral mucosa. Since degradation of collagen by fibroblast phagocytosis is an important pathway for physiological remodelling of soft connective tissues, we have investigated phagocytosis of collagen- and fibronectin-coated latex beads by fibroblast cultures with an in vitro model system. Coated fluorescent latex beads were incubated with human oral mucosa fibroblasts and the fluorescence associated with internalized beads was measured by flow cytometry. Cells from normal tissues that had been incubated with beads for 16 h contained a mean of 75% collagen phagocytic cells and 70% fibronectin phagocytic cells; however, about 15% and 10% of phagocytic cells individually contained more than twice the mean number of beads per cell. In contrast, cells from OSF tissues exhibited a 40% reduction of the proportions of collagen phagocytic cells (mean=35%) and a 48% decrease of the proportions of fibronectin phagocytic cells (mean=22%), none of the cells having a high number of beads as compared to normal fibroblasts. OSF lesions appear to contain fibroblasts with marked deficiencies in collagen and fibronectin phagocytosis. To investigate if inhibition of phagocytosis could be demonstrated in vitro, normal fibroblast cultures were incubated with areca nut alkaloids (arecoline, arecaidine). The cultures had a dose-dependent reduction in the proportions of phagocytic cells. On the other hand, corticosteroid used in the treatment of OSF exhibited a dose-dependent enhancement in the proportion of phagocytic cells. Therefore, our hypothesis for OSF, although oversimplified, is that betel nut alkaloids (arecoline, arecaidine) inhibit fibroblast phagocytosis and this provides a mechanism for the development of OSF. The benefit of a local intralesional injection of corticosteroid is also possibly, at least in part, through an enhancement of fibroblast collagen phagocytosis. PMID- 9950253 TI - Expression of p53 protein correlates with decreased survival in patients with areca quid chewing and smoking-associated oral squamous cell carcinomas in Taiwan. AB - Expression of p53 protein was examined in oral squamous cell carcinoma (SCC) from patients who were areca quid (AQ) chewers and/or tobacco smokers, using anti-p53 antibodies with an immunoperoxidase technique. Positive p53 stain was observed in 47 of 81 (58%) cases of oral SCC. p53 overexpression was found to be higher in patients without AQ chewing and smoking habits than in patients with these two habits (80% vs 52%, P=0.076). No significant correlation was found between p53 expression and the patients' age, sex, cancer location, clinical staging, primary tumor TNM status, or histological differentiation of SCC. The Kaplan-Meier analysis showed that the prognosis for patients with p53-negative tumors was significantly better than that for patients with p53-positive tumors (P<0.05). A significant correlation was also observed between positive lymph node status and poor prognosis (P<0.05). These results suggest that p53 may serve as an adjuvant marker of poor survival in patients with oral SCCs in Taiwan. PMID- 9950252 TI - Effects of areca nut, inflorescence piper betle extracts and arecoline on cytotoxicity, total and unscheduled DNA synthesis in cultured gingival keratinocytes. AB - Betel quid (BQ) chewing has a strong correlation with oral leukoplakia, submucous fibrosis and oral cancer. For elucidation of its pathogenesis, we investigated the effects of areca nut (AN) and inflorescence piper betle (IPB) extracts and arecoline on the growth, total DNA synthesis (TDS) and unscheduled DNA synthesis (UDS) of cultured human gingival keratinocytes (GK). Arecoline and AN extract suppressed the growth of GK over 5 days of incubation in a dose-dependent fashion. At concentrations of 100, 200 and 400 microg/ml, AN extract suppressed the growth of GK by 31%, 46% and 90%, respectively. The IPB extracts exerted less inhibitory effect on the growth of GK. IPB extract (200-400 microg/ml) decreased cell numbers by 20-40% over 5 days of incubation. Moreover, at a concentration of 0.1, 0.2 and 0.4 mM, arecoline suppressed cell growth by 44%, 77% and 96%, respectively. However, only AN extract induced TDS and UDS in cultured GK within 6 h of exposure. Induction of UDS by AN extract was concomitant with the presence of apparent intracellular vacuolization. Arecoline was also toxic to GK, but did not induce intracellular vacuolization. At a concentration range of 200-1600 microg/ml, AN extract induced TDS by 2.1- to 6.5-fold. Furthermore, at a concentration of 400-1600 microg/ml, AN extract elevated the UDS by 2.4- to 5.5 fold more than that of untreated control. On the contrary, IPB extract (200-1600 microg/ml) and arecoline (0.2-1.6 mM) inhibited the TDS and UDS of GK to a different extent. Simultaneous exposure of confluent GK to AN extract, IPB extract and arecoline for 1 to 5 days led to different degrees of cytotoxicity that was dose- and time-dependent. These results indicate that AN, IPB and arecoline take part in the pathogenesis of BQ chewing-related oral mucosal lesions, possibly through both genotoxic and non-genotoxic mechanisms. PMID- 9950254 TI - Aberrant expression of cyclin A and cyclin B1 proteins in oral carcinoma. AB - Cyclins play an important role in regulating the passage of dividing cells through critical checkpoints in the cell cycle. Aberrant expression of cyclin proteins has been found in a number of human cancers, including carcinomas of the head and neck, where amplification of the cyclin D1 gene is a common finding. The objective of this study was to examine cell cycle kinetics in oral carcinomas by determining the expression of the S phase protein cyclin A and the M phase protein cyclin B1. Routinely processed tissue sections of 50 oral squamous cell carcinomas from the floor of the mouth were stained by immunohistochemistry for cyclin A, cyclin B1 and Ki-67 proteins. Ten specimens of normal epithelium from the floor of the mouth were used as controls. The number of cells showing nuclear staining for cyclin A, cyclin B1 and Ki-67 proteins was determined by computer image analysis. There were 17 well-differentiated, 25 moderately differentiated and 8 poorly differentiated tumours. Mean counts for cyclin A (29.50+/-4.10, mean+/-95% CI), cyclin B1 (2.05+/-0.30) and Ki-67 (49.46+/-5.91) proteins in the carcinomas were significantly higher than counts for the normal epithelial controls (cyclin A: 9.30+/-1.72; cyclin B1: 1.01+/-0.36; Ki-67: 17.40+/-4.17). For cyclin A, cyclin B1 and Ki-67, mean staining scores for all tumour grades were significantly higher than controls. There was a strong correlation between Ki-67 and cyclin A scores in all tumour groups (r2=0.68); however, the correlations between cyclin B1 and cyclin A scores (r2=0.35) and between cyclin B1 and Ki-67 scores (r2= 0.39) were weak. We conclude that there is overexpression of cyclin A and cyclin B1 proteins in oral carcinoma. Furthermore, the poor correlations for cyclin B1 scores with other cell cycle indices suggest that there may be aberrant cell cycle progression at the G2/M checkpoint in oral carcinomas. PMID- 9950255 TI - Suppression of Fas receptor and negative correlation of Fas ligand with differentiation and apoptosis in oral squamous cell carcinoma. AB - Apoptosis and the expression of Fas receptor (Fas) and Fas ligand (FasL) were studied in 8 samples of normal oral mucosa (OM) and in 19 oral squamous cell carcinomas (OSCC) by immunohistochemistry and the TUNEL method. Fas was detected in less than 2% of cells in OSCC compared with 84.3+/-9.0% of cells in the basal layer in OM. FasL was found to be highly expressed in poorly differentiated lesions (90.9+/-3.6%), and in cells of both the basal (88.3+/-4.3%) and central (85.3+/-5.7%) parts of moderately differentiated lesions, whereas in well differentiated (WD) lesions expression was considerably lower in both basal (42.7+/-4.1%) and central (11.5+/-2.4%) parts. In normal OM FasL was primarily detected in cells of the basal layer, but in a high proportion of cells (84.9+/ 4.3%). Apoptotic cell death was greater in OSCC (1.6+/-0.6%) than in OM (0.6+/ 0.2%, P<0.05) and was most pronounced in the central part of WD OSCC (2.3+/ 0.5%). Our results show that Fas is expressed in low quantities in OSCC and that FasL expression correlates negatively with degree of differentiation and apoptosis in OSCC. PMID- 9950256 TI - Neuroendocrine (Merkel cell) carcinoma of the oral mucosa: report of a case with immunohistochemical study and review of the literature. AB - Merkel cell carcinoma (Mcc) is an uncommon and aggressive tumour with neuroendocrine features that occur predominantly in the head and neck region. The rarity of this tumour, especially when it arises in the oral mucosa, makes both early identification and standardisation of treatment difficult, particularly as regards complementary treatment. The availability of monoclonal antibodies with restricted specificity for some antigens thought to be related to neuroendocrine carcinomas, such as Merkel cell carcinoma, and ultrastructural studies offer some new leads to investigation. This has allowed, a greater number of these tumours to be discovered, thereby increasing the chances of effective management. A case of Mcc of the floor of the mouth is reported, together with the results of cytokeratin, neuron specific enolase and chromogranin immunohistochemistry. PMID- 9950257 TI - Angiosarcoma of the tongue: report of a case with immunohistochemical findings. AB - A case report of angiosarcoma of the tongue is presented. The specimen revealed single and clustered large, pleomorphic, and spindle-shaped cells with a markedly hemorrhagic background. Tumor cells showed expression of thrombomodulin and E selectin, but no expression of Factor VIII-related antigen, Ulex europaeus agglutinin-1, vascular endothelial growth factor, and CD34. In the current study, immunohistochemical results using antibodies against thrombomodulin and E selection supported the diagnosis of angiosarcoma. PMID- 9950258 TI - Increased platelet sensitivity toward platelet inhibitors during physical exercise in patients with coronary artery disease. AB - Generalized atherosclerosis and coronary artery disease (CAD) are associated with endothelial dysfunction and during acute myocardial ischemia platelet activation has been reported. Activated platelets exert activated fibrinogen receptors (GP IIb/IIIa) and express CD 62p being regarded as reliable marker for platelet activation. Patients with angiographically proven CAD performed a bicycle exercise test until the onset of angina or ST-segment depression. We studied the ischemia-induced alterations in fibrinogen binding to activated platelet GP IIb/IIIa receptors and CD 62p expression. Therefore, the basal fibrinogen binding to GP IIb/IIIa and CD 62p expression and the thrombin-concentration for half maximal platelet activation before and after exercise testing were determined. Additionally, inhibition of thrombin-induced platelet activation by increasing concentrations of the prostacyclin-analog iloprost and the NO-donor SIN-1 was examined. In patients with CAD, a significantly reduced basal activation and a highly significant reduction in sensitivity towards thrombin was measured. The thrombin-induced expression of GP IIb/IIIa and CD 62p was significantly diminished in patients with CAD after physical exercise and their platelets were significantly more sensitive towards the inhibitory effects of iloprost and SIN 1. These data demonstrate a significant reduction in platelet activation in response to physical exercise in patients with CAD and advanced atherosclerosis. Despite exercise induced myocardial ischemia as evidenced by angina and ECG changes, the platelets are not generally activated, as it could be expected. Thus, patients with myocardial ischemia experienced a reduced platelet activity and enhanced sensitivity towards prostacyclin (PGI2) and nitric oxide, probably due to an augmented release of endogenous platelet inhibitory mediators. PMID- 9950259 TI - C677T MTHFR mutation and factor V Leiden mutation in patients with TIA/minor stroke: a case-control study. AB - A common C677T mutation in the gene for the enzyme 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) has been linked to elevated levels of homocysteine and was therefore suspected to be a candidate genetic risk factor for arterial occlusive disease. Another mutation, factor V Leiden, has been established as a common hereditary risk factor for venous thrombosis, but its role in arterial disease remains controversial. We investigated the prevalence of both the C677T MTHFR mutation and the factor V Leiden mutation in 81 patients with transient ischemic attack (TIA) or minor stroke (MS) and in 81 age- and sex-matched control subjects free from clinically manifest vascular disease. We further compared clinical and laboratory data as well as clinical course of patients carrying the factor V Leiden mutation alone or in combination with the C677T MTHFR mutation and mutation-free patients. The prevalence of the MTHFR mutation did not differ between patients and control subjects with 11.1% homozygous carriers in both groups (OR for homozygous carriers 1.0; 95% CI 0.38-2.66). However, there was a trend towards a higher prevalence of carriers of factor V Leiden in patients (12.3%) than in control subjects (4.9%) (OR 2.75; 95% CI 0.83-9.17;p=0.09). Furthermore, we found some evidence that the combined occurrence of the C677T MTHFR mutation and factor V Leiden might unfavorably affect the clinical course of the disease, but the number of respective patients was small. Larger studies with a greater number of carriers of both the C677T MTHFR mutation and factor V Leiden seem therefore warranted. PMID- 9950260 TI - Measurement of prethrombotic markers in the assessment of acquired hypercoagulable states. AB - Hypercoagulable states can be detected by measuring activation peptides, enzyme inhibitor complexes, and fibrin/fibrinogen degradation products, which are markers of hemostatic activation. A series of these prethrombotic markers has been evaluated in the elderly, pregnancy, diabetes and acute myocardial infarction patients (n=30 in each group) as well as in hematologic malignancies (n=42). The parameters assayed were: prothrombin fragment 1+2 (F1+2), thrombin antithrombin III complexes (TAT), fibrinopeptide A (FPA), plasmin-alpha2 antiplasmin complexes (PAP) and D-Dimer. Results were compared with those obtained in a group of 30 healthy subjects. We found a significant increase of F1+2, TAT and FPA in elderly (p<0.05), acute myocardial infarction (AMI) (p<0.01), hematologic malignancies (p<0.01), and pregnancy (p<0.0001), indicating a marked clotting activation. Diabetic patients under strict metabolic control only presented a moderate increase of TAT (p<0.05), suggesting a slight activation. We also observed a highly significant elevation of PAP and D-Dimer in elderly (p<0.001), AMI (p<0.0001), and malignancy (p<0.0001), indicating an activation of the fibrinolytic system. The combination of selected fibrinolytic and coagulation measurements is useful for the detection of a hypercoagulable state in conditions characterized by a risk of thrombosis. PMID- 9950261 TI - Plasma from a patient with thrombotic thrombocytopenic purpura induces endothelial cell apoptosis and platelet aggregation. PMID- 9950262 TI - Response to activated protein C upon storage of whole blood and plasma. PMID- 9950263 TI - Hyperhomocysteinaemia and endothelial dysfunction in peripheral arterial disease. PMID- 9950264 TI - Aurintricarboxylic acid inhibits apoptosis and supports proliferation in a haemopoietic growth-factor dependent myeloid cell line. AB - The actions of the nuclease inhibitor aurintricarboxylic acid (ATA) were investigated in the growth-factor dependent murine myeloid cell line NSF-60. NSF 60 cells proliferate in response to interleukin-3 (IL-3) and undergo apoptosis when deprived of exogenous IL-3, as demonstrated by the appearance of characteristic DNA 'ladders' following agarose gel electrophoresis. ATA, at concentrations between 5 and 25 microM, inhibited apoptosis in growth-factor deprived cells as demonstrated by inhibition of DNA fragmentation and increased cell survival. ATA at a concentration of 25 microM supported proliferation of the cell line in the absence of exogenous growth-factor. Both ATA and IL-3 increased protein phosphorylation in this cell line. ATA and IL-3 induced proliferation was inhibited by the kinase inhibitors genistein, staurosporine and H-7. These findings suggest that, in NSF-60, ATA is not acting exclusively as an endonuclease inhibitor and that protein phosphorylation is involved in the mechanism of action of ATA in this cell line. PMID- 9950265 TI - The role of aminopeptidase N in Met-enkephalin modulated superoxide anion release. AB - We have previously shown that methionine-enkephalin (MENK) alters in dose dependent fashion the capacity of human neutrophils to produce superoxide anion. The response of neutrophils from different donors was diverse and this effect could be due to variable activity of proteolytic enzymes involved in the degradation of the neuropeptide. In this study, we have demonstrated a highly individual aminopeptidase N (APN) activity of neutrophils from different donors. Preincubation of neutrophils with MENK, but not with the synthetic agonist of the mu (DAGO) or the delta (DPDPE) opioid receptor, down-regulated the APN activity. This was paralleled by a loss in cell surface expression of APN at physiological (10(-10) M) concentrations of MENK. The level of APN activity from different donors correlated with the effect of MENK on superoxide anion release. Neutrophils with low APN activity, if preincubated with MENK, released reduced amounts of superoxide anion. In contrast, neutrophils with high APN activity released increased amounts of superoxide anion after preincubation with MENK. Thus, the highly individual APN activity on the surface of neutrophils from different donors seems to be altered by MENK and to be related to the respiratory burst. PMID- 9950267 TI - Consequences of the photodynamic treatment of resting and activated peripheral T lymphocytes. AB - The impact of the immunomodulatory photosensitizer benzoporphyrin derivative monoacid ring A (BPD-MA, verteporfin) and visible light on the survival and surface receptor pattern of resting and activated murine T cells was evaluated. T cells treated for 48 h with immobilized anti-CD3 monoclonal antibody upregulated expression of the interleukin-2 receptor alpha-chain (CD25), transferrin receptor (CD71), the apoptosis-regulating Fas receptor (CD95), contained a greater level of the anti-apoptotic protein Bcl-2 and accumulated significantly more BPD-MA than their unactivated counterparts. Activated T cells displayed a modestly greater susceptibility to the photodynamic induction of DNA fragmentation than resting T cells. Resting T cells treated with sub-lethal levels of BPD-MA and light did not exhibit changes in surface levels of CD3, CD4, CD8, CD28, CD45 or T cell receptor (TCR) beta-chain structures. However, levels of major histocompatibility complex (MHC) class I antigens were decreased while the density of Thy-1.2 (CD90) increased on these cells. Photodynamically treated T cells failed to express optimal CD25 levels when exposed to the mitogenic anti CD3 antibody. Activated T cells treated with sub-lethal levels of BPD-MA and light exhibited lower CD25 levels, a temporary block in cell cycle transition, but unaltered expression of MHC Class I, CD3, CD4, CD8, CD45, CD54, CD71, CD122 (IL-2R beta-chain) or TCR beta-chain antigens 24 h afterward. Resting and activated T lymphocytes differ in susceptibility to PDT-mediated apoptosis but both types are sensitive to anti-proliferative effects the treatment exerts at sub-lethal photosensitizer levels. The marked sensitivity of activated T cells to photodynamic inactivation likely contributes to the immunomodulatory action of BPD-MA. PMID- 9950266 TI - Alpha 1-acid glycoprotein-induced tumor necrosis factor-alpha secretion of human monocytes is enhanced by serum binding proteins and depends on protein tyrosine kinase activation. AB - The acute phase protein, alpha1 acid glycoprotein (AGP), stimulated human mononuclear cells as well as monocytes to secrete tumor necrosis factor-alpha (TNFalpha) which was demonstrated by ELISA, RT-PCR and functional assays. AGP induced TNFalpha secretion of monocytes was enhanced in the presence of human plasma and inhibited by protein kinase inhibitors, indicating it is serum and tyrosine kinase dependent. The activation of tyrosine kinase in AGP-stimulated monocytes was further confirmed by immunoblotting of tyrosine phosphorylated proteins of monocytes at different time after AGP stimulation. Furthermore, several serum proteins such as C3, sCD14 and IgG were able to bind to AGP and enhanced TNFalpha secretion of human monocytes induced by AGP. Taken together, these results suggest serum proteins binding to AGP enhance its ability to stimulate human monocytes to secrete pro-inflammatory cytokines through a tyrosine kinase dependent pathway. PMID- 9950268 TI - Trichilia glabra: effect on the phagocytic activity and respiratory burst response of peritoneal macrophages. AB - A diminution in the phagocytic capability and respiratory burst response of murine peritoneal macrophages was observed when these cells were treated 'in vitro' with Trichilia glabra leaf aqueous extract. The effect was not observed when non-specific phagocytosis was tested. The extract also inhibited binding of opsonized erythrocytes to macrophages, thus indicating that the observed antiphagocytic effect is possibly due to the failure of opsonized particles to bind to these cells. A low molecular weight fraction is responsible for the reported activities. PMID- 9950269 TI - Ultraviolet B (UVB) light-induced histamine release from rat peritoneal mast cells and its augmentation by certain phenothiazine compounds. AB - When rat peritoneal mast cells were exposed to ultraviolet (UV) light (UVA, UVB and UVC), histamine release was evoked in a dose (intensity X time) dependent manner. The potency order of UV light in inducing the histamine release was UVC > UVB >> UVA. In this study, we focused on the effect of ultraviolet B (UVB) on histamine release from rat mast cells. The UVB-induced histamine release occurred at doses higher than 7.8 kJ m(-2), even at 4 degrees C. At a UVB dose of 18.8 kJ m(-2), where a 51.9+/-4.8% histamine release and a 58.8+/-6.8% degranulation took place, Trypan blue-stained cells accounted for 14.4+/-1.3% of the cells, and the lactate dehydrogenase (LDH) release was about 4.9+/-2.8%. This suggests that the membrane permeability to low molecular weight substances was increased by UVB exposure. The UVB-induced histamine release was inhibited by ascorbic acid at concentrations higher than 500 microM, suggesting the involvement of a radical reaction in the process. The UVB-induced histamine release was enhanced by some phenothiazine compounds, i.e., promethazine, trimeprazine, mequitazine, chlorpromazine, trifluoperazine, ethopropazine and thioridazine. We conclude that the phototoxicity of phenothiazine compounds may be due in part to an enhancement of UVB-induced histamine release from mast cells. PMID- 9950270 TI - Mediator-dependent effects of pentoxifylline on endothelium for transmigration of neutrophils. AB - In the present study, we investigated the effects of the anti-inflammatory drug pentoxifylline (PTX) on activation of endothelial cells for enhanced adhesion and transmigration of neutrophils by lipopolysaccharide (LPS), tumor necrosis factor alpha (TNF), interleukin-1 (IL-1) and granulocyte colony-stimulating factor (G CSF). To evaluate the mechanism by which PTX exerts its effect, human umbilical vein endothelial cells (HUVEC) were pretreated with theophylline, 2'-O-dibutyryl 3', 5'-cyclic adenosine monophosphate (db cAMP), and 3-isobutyl-1-methylxanthine, respectively, prior to stimulation. Pretreatment of HUVEC with PTX significantly antagonized TNF-, IL-1-, and G-CSF-activated transmigration of neutrophils. Additive stimulatory effects of PTX were seen with LPS. With the exception of theophylline, all other test cAMP-raising agents stimulated transmigration in similar fashion to PTX. Upon stimulation with TNF or LPS, HUVEC produced IL-8 and PTX affected this process in opposing fashions, with inhibition of the effects of TNF and augmentation of those of LPS. These results demonstrate that PTX differentially affects mediator-induced activation of HUVEC. The present IL-8 dependent and cAMP-regulated augmentation of LPS-induced stimulation of transmigration is the first description of an additive effect of PTX with a pro inflammatory agent. PMID- 9950271 TI - Artificial neural network as a novel method to optimize pharmaceutical formulations. AB - One of the difficulties in the quantitative approach to designing pharmaceutical formulations is the difficulty in understanding the relationship between causal factors and individual pharmaceutical responses. Another difficulty is desirable formulation for one property is not always desirable for the other characteristics. This is called a multi-objective simultaneous optimization problem. A response surface method (RSM) has proven to be a useful approach for selecting pharmaceutical formulations. However, prediction of pharmaceutical responses based on the second-order polynomial equation commonly used in RSM, is often limited to low levels, resulting in poor estimations of optimal formulations. The aim of this review is to describe the basic concept of the multi-objective simultaneous optimization technique in which an artificial neural network (ANN) is incorporated. ANNs are being increasingly used in pharmaceutical research to predict the non-linear relationship between causal factors and response variables. The usefulness and reliability of this ANN approach is demonstrated by the optimization for ketoprofen hydrogel ointment as a typical numerical example, in comparison with the results obtained with a classical RSM approach. PMID- 9950272 TI - Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability. AB - To evaluate the cellular permeation characteristics and the chemical and enzymatic stability of coumarinic acid-based cyclic prodrugs 1 and 2 of the opioid peptides [Leu5]-enkephalin (H-Tyr-Gly-Gly-Phe-Leu-OH) and DADLE (H-Tyr-D Ala-Gly-Phe-D-Leu-OH), respectively. METHODS: The rates of conversion of the cyclic prodrugs 1 and 2 to [Leu5]-enkephalin and DADLE, respectively, in HBSS, pH 7.4 (Caco-2 cell transport buffer) and in various biological media having measurable esterase activity were determined by HPLC. The cell permeation characteristics of [Leu5]-enkephalin, DADLE and cyclic prodrugs 1 and 2 were measured using Caco-2 cell monolayers grown onto microporus membranes and monitored by HPLC. RESULTS: In HBSS, pH 7.4, cyclic prodrugs 1 and 2 degraded chemically to intermediates that further degraded to [Leu5]-enkephalin and DADLE, respectively, in stoichiometric amounts. In 90% human plasma and rat liver homogenate, the disappearance of cyclic prodrugs 1 and 2 was significantly faster than in HBSS, pH 7.4. The half-lives in 90% human plasma and in rat liver homogenate were substantially longer after pretreatment with paraoxon, a known inhibitor of serine-dependent esterases. When applied to the AP side of a Caco-2 cell monolayer, cyclic prodrug 1 exhibited significantly greater stability against peptidase metabolism than did [Leu5]-enkephalin. Cyclic prodrug 2 and DADLE exhibited similar stability when applied to the AP side of the Caco-2 cell monolayer. Prodrug 1 was 665-fold more able to permeate the Caco-2 cell monolayers than was [Leu5]-enkephalin, in part because of its increased enzymatic stability. Prodrug 2 was shown to be approximately 31 fold more able to permeate a Caco-2 cell monolayer than was DADLE. CONCLUSIONS: Cyclic prodrugs 1 and 2, prepared with the coumarinic acid promoiety, were substantially more able to permeate Caco-2 cell monolayers than were the corresponding opioid peptides. Prodrug 1 exhibited increased stability to peptidase metabolism compared to [Leu5]-enkephalin. In various biological media, the opioid peptides were released from the prodrugs by an esterase-catalyzed reaction, which is sensitive to paraoxon inhibition. PMID- 9950274 TI - Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers. AB - PURPOSE: To evaluate the chemical and enzymatic stability, as well as the cellular permeation characteristics, of the acyloxyalkoxy-based cyclic prodrugs 1 and 2 of the opioid peptides [Leu5]-enkephalin (H-Tyr-Gly-Gly-Phe-Leu-OH) and DADLE (H-Tyr-D-Ala-Gly-Phe-D-Leu-OH), respectively. METHODS: The rates of conversion of 1 and 2 to [Leu5]-enkephalin and DADLE, respectively, were measured by HPLC in HBSS, pH = 7.4, and in various biological media (e.g., human plasma and Caco-2 cell and rat liver homogenates) having measurable esterase activity. The cellular permeation and metabolism characteristics of [Leu5]-enkephalin, DADLE and the cyclic prodrugs 1 and 2 were measured using Caco-2 cell monolayers grown onto microporous membranes and monitored by HPLC. RESULTS: Cyclic prodrugs 1 and 2 degraded slowly but stoichiometrically to [Leu5]-enkephalin and DADLE, respectively, in HBSS, pH = 7.4. In homogenates of Caco-2 cells and rat liver, as well as 90% human plasma, the rates of disappearance of the cyclic prodrugs were significantly faster than in HBSS. The stabilities of the cyclic prodrugs 1 and 2 were increased significantly in 90% human plasma and Caco-2 cell homogenates when paraoxon, a potent inhibitor of serine-dependent esterases, was included in the incubation mixtures. A similar stabilizing effect of paraoxon was not observed in 50% rat liver homogenates, but was observed in 10% homogenates of rat liver. When applied to the AP side of a Caco-2 cell monolayer, DADLE and cyclic prodrugs 1 and 2 exhibited significantly greater stability than [Leu5]-enkephalin. Based on their physicochemical properties (i.e., lipophilicity), cyclic prodrugs 1 and 2 should have exhibited high permeation across Caco-2 cell monolayers. Surprisingly, the AP-to-BL apparent permeability coefficients (P(App)) for cyclic prodrugs 1 and 2 across Caco-2 cell monolayers were significantly lower than the P(App) value determined for the metabolically stable opioid peptide DADLE. When the P(App) values for cyclic prodrugs 1 and 2 crossing Caco-2 cell monolayers in the BL-to-AP direction were determined, they were shown to be 36 and 52 times greater, respectively, than the AP-to-BL values. CONCLUSIONS: Cyclic prodrugs 1 and 2, prepared with an acyloxyalkoxy promoiety, were shown to degrade in biological media (e.g., 90% human plasma) via an esterase-catalyzed pathway. The degradation of cyclic prodrug 1, which contained an ester formed with an L-amino acid, degraded more rapidly in esterase-containing media than did prodrug 2, which contained an ester formed with a D-amino acid. Cyclic prodrugs 1 and 2 showed very low AP-to-BL Caco-2 cell permeability, which did not correlate with their lipophilicities. These low AP-to-BL permeabilities result because of their substrate activity for apically polarized efflux systems. PMID- 9950273 TI - Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation. AB - PURPOSE: To evaluate the cellular permeation characteristics and the chemical and enzymatic stability of phenylpropionic acid-based cyclic prodrugs 1 and 2 of opioid peptides [Leu5]-enkephalin (H-Tyr-Gly-Gly-Phe-Leu-OH) and DADLE (H-Tyr-D Ala-Gly-Phe-D-Leu-OH), respectively. METHODS: The rates of conversion of cyclic prodrugs 1 and 2 to [Leu5]-enkephalin and DADLE, respectively, in HBSS, pH 7.4 (Caco-2 cell transport buffer) and in various biological media having measurable esterase activity were determined by HPLC. The cell permeation characteristics of [Leu5]-enkephalin, DADLE, and cyclic prodrugs 1 and 2 were measured using Caco-2 cell monolayers grown onto microporus membranes and monitored by HPLC. RESULTS: In HBSS, pH 7.4, cyclic prodrugs 1 and 2 degraded to [Leu5]-enkephalin and DADLE, respectively, in stoichiometric amounts. In 90% human plasma, the rates of disappearance of cyclic prodrugs 1 and 2 were slightly faster than in HBSS, pH 7.4. These accelerated rates of disappearance in 90% human plasma could be reduced to the rates observed in HBSS, pH 7.4, by pretreatment of the plasma with paraoxon, a known inhibitor of serine-dependent esterases. In homogenates of Caco 2 cells and rat liver, accelerated rates of disappearance of cyclic prodrugs 1 and 2 were not observed. When applied to the AP side of a Caco-2 cell monolayer, cyclic prodrug 1 exhibited significantly greater stability against peptidase metabolism than did [Leu5]-enkephalin. Cyclic prodrug 2 and DADLE exhibited stability similar to prodrug 1 when applied to the AP side of the Caco-2 cell monolayers. Prodrug 1 was 1680 fold more able to permeate the Caco-2 cell monolayers than was [Leu5]-enkephalin, in part because of its increased enzymatic stability. Prodrug 2 was shown to be approximately 77 fold more able to permeate a Caco-2 cell monolayer than was DADLE. CONCLUSIONS: Cyclic prodrugs 1 and 2, prepared with the phenylpropionic acid promoiety, were substantially more able to permeate Caco-2 cell monolayers than were the corresponding opioid peptides. Prodrug 1 exhibited increased stability to peptidase metabolism compared to [Leu5]-enkephalin. In 90% human plasma but not in Caco-2 cell and rat liver homogenates, the opioid peptides were released from the cyclic prodrugs by an esterase-catalyzed reaction that is sensitive to paraoxon inhibition. However, the rate of this bioconversion appears to be extremely slow. PMID- 9950275 TI - Submicron cationic emulsions as a new delivery system for oligonucleotides. AB - PURPOSE: The main purpose of the present study was to investigate submicron emulsions as potential oligonucleotide (ON) delivery system. METHODS: Submicron emulsions containing various concentrations of stearylamine (SA) were prepared by microfluidization. After association with model oligothymidylates, these emulsions were characterized in terms of particle size, zeta-potential, association efficiency and release upon dilution. The interactions between ON and SA were investigated by partitioning studies between water and oily phases, with ON of three different lengths (pdT16, pdT30, pdT50). The stability of pdT16 in the presence of nucleases was evaluated by incubation in cell culture medium supplemented with 10% of foetal calf serum. RESULTS: The ON association efficiency was much higher with emulsions containing SA (E(SA)) than with control emulsions (E0), whatever the ON length. In addition, E(SA) was shown to protect ON against degradation for up to 3 hours in culture medium. ON and SA were able to form ion-pairs and the resulting complex was found to be insoluble both in water and in oil. Zeta potential was maintained constant when increasing the ON concentration, until flocculation occurred (up to 250 microM in the case of pdT16 for example). This has been explained by the presence of SA in excess, soluble in the oily core of droplets, able to migrate towards the interface and replacing SA neutralized in ion-pairs. CONCLUSIONS: ESA appears to be a valuable system for delivery of ON and might even be improved by selecting an oily phase in which the SA/ON complex would be soluble. PMID- 9950276 TI - Spleen capture of nanoparticles: influence of animal species and surface characteristics. AB - PURPOSE: To investigate the influence of animal species and nanoparticle surface characteristics on the intrasplenic distribution of polystyrene nanoparticles. METHODS: Two types of fluorescent polystyrene nanoparticles (Estapor and Fluoresbrite), plain or coated, were used in mice and rats. First, a fluorimetric method was developed for nanoparticle tissue quantification. Then, intrasplenic distribution of plain or coated nanoparticles was studied using histological examination and image analysis. Finally, the role of direct interactions between nanoparticles and spleen capturing cells was assessed by in vitro binding assays, using incubation of thick spleen slices with polystyrene nanoparticles. RESULTS: The two types of polystyrene nanoparticles showed different levels of trapping: Fluoresbrite nanoparticles were more efficiently trapped by the spleen than Estapor nanoparticles, both in mice and rats. In mice, most of the injected nanoparticles were localized in the marginal zone of the spleen, involving a special population of capturing cells, while in rats, the predominant capture occured in the red pulp. In mice, coated nanoparticles were localized both in the marginal zone and in the red pulp, whereas the coating did not seem to change the intrasplenic distribution of the nanoparticles in rats. CONCLUSIONS: These complementary approaches showed different uptake pathways of nanoparticles, according to their surface characteristics and the rodent species used. PMID- 9950277 TI - Penetration studies of clotrimazole from semisolid formulation using step-scan FT IR photoacoustic spectroscopy. AB - PURPOSE: The aim of this study was to elucidate the potential use of the step scan FT-IR photoacoustic spectroscopy (PAS) for the non-destructive determination of drug penetration into membranes. METHODS: The penetration of clotrimazole from a 10% (w/w) suspension in Vaseline into a dodecanol-collodion acceptor membrane was studied by three methods: the step-scan FT-IR PAS with a phase modulation, a multilayer membrane system, and a modified libration model. Based on Fick's second law, the diffusion coefficient of the drug in the membrane was derived by numerical fitting of the experimental data. RESULTS: The three methods applied provided almost the same diffusion coefficient D = 2.2 10(-9) cm2/s for clotrimazole in the membrane. Because of the non-destructive mode of operation, the accuracy of results obtained by FT-IR PAS is much better than that attainable by other two methods. CONCLUSIONS: Step-scan FT-IR photoacoustic spectroscopy in conjunction with a phase modulation is useful to determine the penetration of drug through membranes. The fact that samples can be investigated without elaborate preparation is an advantage of this spectroscopic technique. PMID- 9950278 TI - Lateral iontophoretic solute transport in skin. AB - PURPOSE: The lateral iontophoretic transport of three solutes (sodium, ethanolamine, lidocaine) from an active electrode through skin and other tissues to an indifferent electrodes was investigated. METHODS: Anodal epidermal iontophoresis was carried out on an in vivo rat model using constant direct current of 0.38 mA/cm2. Cells were fixed on the epidermis of anesthetized rats at distances of adjacent, 3 cm and 7 cm apart. After iontophoresis, tissues were dissected at I cm intervals between the electrodes. Concentrations of the radiolabelled solutes in tissues were determined by liquid scintillation counting or gamma counting. RESULTS: The concentration of each solutes in the epidermis, dermis and other tissues was found to decrease in an exponential manner with lateral distance from the active electrode to the indifferent electrode. The detectable lateral distance for ethanolamine and lidocaine was less than 2 cm from the donor sites, at which distance the concentrations were not significantly different to those found in the corresponding contralateral site. The lateral drift velocities for all solutes in the epidermis and dermis were consistent with diffusivities of the order of 10(-6) cm2/s. The drift velocity of sodium was greater than either lidocaine or ethanolamine. CONCLUSIONS: The decline in solute concentration with lateral distance is mainly due to clearance from the site of application by the skin's microcirculation and decreases with distance from the active electrode until a baseline concentration, similar to the contralateral tissue concentration is reached. PMID- 9950279 TI - Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. AB - PURPOSE: This study on the intestinal transport of beta-lactam antibiotics was undertaken to investigate the correlation between cellular transport parameters and the bioavailability. METHODS: Transport of 23 beta-lactam antibiotics was characterized by measuring their ability to inhibit the uptake of glycylsarcosine into Caco-2 cells, their uptake into the cells and their total flux across the cell monolayers. RESULTS: Ceftibuten and cyclacillin were recognized by PEPT1 with affinity constants comparable to those of natural dipeptides (K(i) = 0.3 and 0.5 mM, respectively). Cefadroxil, cefamandole, cephradine, cefaclor, cefuroxime axetil, cefixime, cephalotin, cephalexin and ampicillin also interacted with PEPTI (K(i) = 7-14 mM). In contrast, cefapirin, cefodizime, cefuroxime, cefmetazole, ceftazidime, benzyl-penicillin, ceftriaxone, cefpirome, cefotaxime, cefepime, cephaloridine and cefsulodin displayed no affinity to the transport system (K(i) > 20 mM). The uptake into the cells and the transepithelial flux was highest for those beta-lactam antibiotics, which showed the strongest inhibition of [14C]Gly-Sar transport (p < 0.0001). Exceptions were cefuroximaxetil and cephalotin. CONCLUSIONS: The probability of oral bioavailability for beta-lactam antibiotics is mainly determined by their affinity to PEPTI. A threshold K(i) value of 14 mM with respect to Gly-Sar uptake is required. PMID- 9950280 TI - Structure-transport relationship for the intestinal small-peptide carrier: is the carbonyl group of the peptide bond relevant for transport? AB - PURPOSE: The objective of this study was to determine the influence of the peptide bond with emphasis on the carbonyl group on the interaction with and transport by the intestinal small-peptide carrier. Therefore enalapril, a known substrate for the small-peptide carrier, has been modified to an analogue with a reduced peptide bond, enamipril. The transport characteristics of both compounds have been determined. METHODS: The in vitro transport studies were performed using rat ileum in Ussing chambers. The transport of enalapril and enamipril were measured in a concentration range from 0.5-8 mM in both directions across the ileum. in the presence and absence of inhibitors. The interaction with the small peptide carrier was studied by evaluating the ability of enalapril and its analogue enamipril to inhibit the transport rate of amoxycillin. RESULTS: Enalapril shows, besides passive diffusion (P(m)3.06+/-0.14 . 10(-6)cm/s), saturable transport kinetics (Jmax = 16+/-5 nmol/h.cm2, Km = 1.86+/-0.64 mM) which can be inhibited with 10 mM cephalexin. The analogue with a reduced peptide bond does not show saturable transport from the mucosal to the serosal side, and cephalexin does not inhibit the flux of enamipril. However, the transport of enamipril from the serosal to mucosal side of the intestinal membrane is saturable and can be inhibited by 100 microM verapamil. Although enamipril is not a substrate for the small-peptide carrier in contrast to enalapril, both enalapril and enamipril are able to inhibit the active transport of amoxycillin with a K(i) of 0.41+/-0.24 mM and 0.24+/-0.12 mM respectively. CONCLUSIONS: The reduction of the peptide bond of enalapril results in a compound, enamipril, which does not show polarized and saturable transport from the mucosal to the serosal side of the intestinal tissue. Also because the transport of enamipril cannot be inhibited by cephalexin, the analogue with the reduced peptide bond is no longer a substrate for the intestinal small-peptide carrier. Therefore, it can be concluded that the carbonyl group is an essential structural requirement for transport by the small-peptide carrier. In contrast, the interaction with the small-peptide carrier is still present, shown by the inhibition of the fluxes of amoxycillin. Reduction of the peptide bond of enalapril resulted in a new substrate for the P-glycoprotein efflux pump. PMID- 9950281 TI - Intestinal absorption of acyclovir beta-glucoside: comparative study with acyclovir, guanosine, and kinetin beta-glucoside. AB - PURPOSE: To characterize the intestinal absorption of a beta-glucose conjugate of acyclovir (9-[(2-hydroxyethoxy) methyl] guanine, ACV) and compare it to ACV and its analogues in terms of stability and transport by Na+/glucose cotransporter (SGLTI). METHODS: ACVbeta(glc) was enzymatically synthesized using cellulase. Intestinal absorption experiments were performed with rat everted small intestine. Conformation of the glucose moiety was analyzed by NMR spectroscopy. RESULTS: The ACVbeta(glc) was stable on the mucosal side, and was transported to the serosal side in all regions of the small intestine. However, significant contribution of SGLTI to the transport of ACVbetaglc was not observed. NMR spectroscopic analysis indicated that the glucose conformation of ACVbeta(glc) was the 4C1 chair form, identical to beta-glucose or SGLT1-transportable beta glucosides reported previously. Therefore, other factors such as molecular size and charge due to aglycone may cause no transport of ACVbeta(glc) by SGLT1. On the other hand, the hydrophilicity of ACVbeta(glc) was much higher than of ACV, suggesting water solubility-derived improvement of intestinal absorption of ACV. CONCLUSIONS: ACVbeta(glc) is stable and absorbable, but it is not transported by SGLT1. No involvement of SGLT1 in the ACVbeta(glc) transport is not due to glucose conformation. PMID- 9950282 TI - Inhibition of binding of an enzymatically stable thrombin inhibitor to lumenal proteases as an additional mechanism of intestinal absorption enhancement. AB - PURPOSE: The objective of the study was to investigate the mechanisms behind increased bioavailability of an enzymatically stable thrombin inhibitor, inogatran, after coadministration with a trypsin inhibitor, aprotinin. METHODS: Rat jejunum, ileum and colon segments were stripped and mounted in modified Ussing chambers, and the permeability to inogatran was determined both in the presence and absence of aprotinin. Inogatran and aprotinin were also coadministered intraduodenally to conscious rats. Competitive binding of inogatran to trypsin was studied using kinetic dialysis and was compared to aprotinin. The fraction of free (unbound) trypsin probe, in the absence of trypsin inhibitors was determined by performing experiments without pancreatine and without inhibitors, respectively. RESULTS: A 3-fold increased permeability to inogatran in the presence of aprotinin was seen in vitro, in some cases correlated with changed barrier properties of the intestinal segments. The in vitro results were well correlated with the in vivo results. There was a 5-fold increase in the bioavailability of inogatran in the presence of aprotinin. The binding of a trypsin probe was inhibited by both the presence of inogatran and aprotinin. Aprotinin showed a several fold higher displacement than inogatran. The results indicate both an effect of aprotinin on the epithelial membrane and an inhibition of binding of the thrombin inhibitor to trypsin or other serine proteases in the gut. CONCLUSIONS: The coadministration of aprotinin with enzymatically stable peptides, like thrombin inhibitors, may improve their absorption after oral administration. This suggests a new additional mechanism for intestinal absorption enhancement of peptide drugs. PMID- 9950283 TI - In vitro and in vivo evaluation of the enhancing activity of glycyrrhizin on the intestinal absorption of drugs. AB - PURPOSE: The enhancing activity of dipotassium glycyrrhizinate (Grz) on the intestinal absorption of drugs has been demonstrated in an in vitro study using Caco-2 cell monolayers and in an in vivo absorption study in rats. METHODS: The hydrolysis of Grz by luminal content and mucosa of the rat colon was investigated. The absorption-enhancing activity of Grz and its hydrolysates was estimated by changes in transepithelial electrical resistance (TEER) and the permeation of sodium fluorescein (Flu-Na) in Caco-2 cell monolayers. It was further evaluated through the absorption of salmon calcitonin (sCT) in the rat colon. RESULTS: Grz was not hydrolyzed to glycyrrhetinylmonoglucuronide (GrMG) and glycyrrhetinic acid (GA) by colonic mucosa, but, rather by the beta glucuronidase in colonic flora. The hydrolysis of Grz to GrMG was extremely slow and the GrMG produced was rapidly regenerated to GA. Grz and GrMG had no effect on TEER nor on the permeability of Flu-Na across Caco-2 cell monolayers. On the other hand, GA decreased TEER and increased the permeability of Flu-Na in a dose dependent manner. However, Grz and GrMG enhanced the plasma calcium-lowering effect of sCT after administration in the rat colon. The coadministration of sCT and GA in the rat colon induced the strongest plasma calcium-lowering effect and the highest plasma concentration of sCT. CONCLUSIONS: The in vivo enhancing activity of Grz in the absorption of drugs is dependent on GA, a hydrolysis product of Grz resulting from the action of beta-glucuronidase in intestinal flora. PMID- 9950284 TI - Heterogeneous tube model for the study of small intestinal transit flow. AB - PURPOSE: A Monte-Carlo computer simulation technique was employed to study the details of the small intestinal transit flow in the gastrointestinal (GI) tract. METHODS: A heterogeneous tube model was constructed using a numerical computer simulation technique. The model was built from first principles and included several heterogeneous characteristics of the GI tract structure. We used a random, dendritic-type internal structure representing the villi of the GI tract. The small intestinal transit flow was simulated using two diffusion models, namely, the blind ant and the myopic ant models, which are different models to account the elapse of time, and which are both based on statistical properties of random walks. For each one of the models we utilize two types of biased random walk, placing different emphasis in the motion towards the output of the tube. We monitored the flow of the drug in terms of Monte-Carlo time steps (MCS) through the tube walls and dendritic villi present. RESULTS: The frequency of the transit times was dependent on the structure of the dendritic villi and on the type of biased random walk. The small intestinal flow profile of literature data for a large number of drugs was well characterized by the heterogeneous model using, as parameters, a certain number of villi per unit length of the tube and specific characteristics for both types of the biased random walk. A correspondence between the MCS and real time units was achieved. CONCLUSIONS: The transit process of the oral dosage forms in the GI tract can be reproduced with the heterogeneous model developed. This model can be used to study GI absorption phenomena. PMID- 9950285 TI - The effect of oleic acid on the human ileal brake and its implications for small intestinal transit of tablet formulations. AB - PURPOSE: A human volunteer study was carried out to investigate whether activation of the ileal brake mechanism affects the transit of tablets through the small intestine. METHODS: Oleic acid, which has previously been shown to activate the brake, was delivered to the small intestine in a modified release capsule at doses of 300 mg, 600 mg and 1200 mg. The effect of the oleic acid was determined by measuring the transit of two sets of radiolabelled tablets by gamma scintigraphy. One set of tablets was dosed with the capsule and the other one hour later. RESULTS: The results show that in the majority of the volunteers small intestinal residence time was greater with the oleic acid than control. The effect was most pronounced in the tablets given concomitantly with the capsule and with the higher doses of oleic acid. CONCLUSIONS: The ileal brake, activated by oleic acid, can slow the transit of tablets through the small intestine. PMID- 9950286 TI - Surface activity and concentration dependent intestinal permeability in the rat. AB - PURPOSE: To investigate the relation between intestinal effective permeability (P(eff)) and surface activity of fluvastatin and verapamil. METHODS: P(eff) values were determined for fluvastatin, antipyrine and D-glucose following colon perfusions in the rat in situ. The perfusion solitions differed regarding concentrations of fluvastatin (0-2500 microM) and surface tension (58.9-43.7 mN/m). A cellulose derivative, ethyl-(hydroxyethyl) cellulose (EHEC), was added to lower the surface tension of one of the perfusion solutions. The surface tension of perfusion solutions containing R/S-verapamil (8-814 microM) and R/S verapamil + chlorpromazine (814 microM + 10 mM) were related to the corresponding P(eff)-values from the literature. RESULTS: The P(eff)of fluvastatin correlated inversely (r2 = 0.985, p < 0.05) with the surface tension of the perfusion solutions below the critical micelle concentration (CMC, 1 mM). Decreasing the surface tension with EHEC increased the P(eff) of fluvastatin by 36% (p < 0.001), but not to the extent anticipated from the correlation between the P(eff) and the surface tension. EHEC also increased the P(eff) of antipyrine by 49% (p < 0.01 ) but not for D-glucose. The P(eff) of R/S-verapamil correlated inversely with the surface tension (r2 = 0.980, p < 0.001). CONCLUSIONS: The ability of fluvastatin to decrease the surface tension at the membrane surface can partly explain the concentration dependent colonic P(eff) of fluvastatin. This study shows that the surface activity of the drug molecule itself is an important physicochemical factor that should be taken into consideration when evaluating drug absorption studies performed in vitro or in situ. PMID- 9950288 TI - Determination of the rate-limiting step in the hepatic elimination of YM796 by isolated rat hepatocytes. AB - PURPOSE: The membrane permeability clearance and intrinsic metabolic clearance of a drug in the liver were estimated using isolated rat hepatocytes, and the rate limiting step in the overall intrinsic clearance of the drug in vivo was investigated. For this purpose, an anti-dementia drug, (S)-(-)-2,8-dimethyl-3 methylene-1-oxa-8-azaspiro [4,5] decane-L-tartarate monohydrate (YM796) was used as a model drug. METHODS: The parent drug and its metabolites in both medium and cells were separated by thin-layer chromatography (TLC). The total amount of drug taken up by hepatocytes and the total amount of metabolites were plotted against the AUC of YM796 in the medium or cells to obtain the kinetic parameters. RESULTS: While the influx clearance (PS(inf)) through the sinusoidal membrane defined in terms of YM796 concentration in the medium was almost constant, irrespective of the concentration of YM796 in the medium, the intrinsic metabolic clearance (CL(int)) and the efflux clearance (PS(eff)) defined in terms of the total concentration of YM796 in the cells markedly decreased and increased, respectively, as the concentration of YM796 increased. The overall intrinsic metabolic clearance (CL(int,all), defined in terms of the YM796 concentration in the medium, corresponding to the hepatic intrinsic clearance obtained from the in vivo pharmacokinetic data on the drug, was comparable with PS(inf) at low concentrations of YM796. As the YM796 concentration increased, however, CL(int,all) fell markedly approaching CL(int). CONCLUSIONS: While, at low concentrations of YM796, CL(int,all) was predominantly affected by membrane permeability clearance, at high concentrations it was completely rate-determined by the intrinsic metabolic clearance because of the marked reduction in CL(int) resulting from the saturation of YM796 metabolism. PMID- 9950287 TI - Analysis of nonlinear hepatic clearance of a cyclopentapeptide, BQ-123, with the multiple indicator dilution method using the dispersion model. AB - PURPOSE: To bridge in vitro, in situ and in vivo kinetic analyses of the hepatic clearance of a cyclopentapeptide, BQ-123, by using dispersion models that assume nonlinear pharmacokinetics. METHODS: Rat livers were perfused by the multiple indicator dilution method with doses of BQ-123 ranging from 1-1000 microg. The outflow dilution curves were fitted to a two-compartment dispersion model that was solved numerically by the finite difference method. Further, in vivo plasma concentrations of BQ-123 after bolus injection were analyzed with a hybrid physiological model that incorporates the hepatic dispersion model. RESULTS: The calculated Michaelis-Menten constants (Km = 12.0 microM, Vmax = 321 pmol/min/10(6) cells, P(dif) = 1.2 microl/min/10(6) cells) were comparable to those obtained previously from the in vitro isolated hepatocyte experiment (Km = 9.5 microM, Vmax = 517 pmol/min/l0(6) cells, P(dif) = 1.1 microl/min/10(6) cells). The plasma concentrations of BQ-123 at doses of 1-25 mg/kg were explained well by the hybrid physiological model. CONCLUSIONS: These results suggest that carrier-mediated transport on the sinusoidal membrane was responsible for the in vivo hepatic elimination of BQ-123. PMID- 9950289 TI - Pharmacokinetics and biologic activity of the novel mast cell inhibitor, 4-(3 hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in mice. AB - PURPOSE: The purpose of the present study was to examine the pharmacodynamic and pharmacokinetic features of the novel mast cell inhibitor 4-(3'-Hydroxyphenyl) amino-6,7-dimethoxyquinazoline (WHI-P180) in mice. METHODS: A high performance liquid chromatography (HPLC)-based quantitative detection method was used to measure plasma WHI-P180 levels in mice. The plasma concentration-time data was fit to a single compartment pharmacokinetic model by using the WinNonlin program to calculate the pharmacokinetic parameters. A cutaneous anaphylaxis model was used to examine the pharmacodynamic effects of WHI-P180 on anaphylaxis-associated vascular hyperpermeability. RESULTS: The elimination half-life of WHI-P180 in CD 1 mice (BALB/ c mice) following i.v., i.p., or p.o. administration was less than 10 min. Systemic clearance of WHI-P180 was 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibited IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis. CONCLUSIONS: WHI-P180 is an active inhibitor of IgE-mediated mast cell responses in vitro and in vivo. Further preclinical characterization of WHI P180 may improve the efficacy of WHI-P180 in vivo and provide the basis for design of effective treatment and prevention programs for mast cell mediated allergic reactions. PMID- 9950290 TI - Dependency of gastrointestinal toxicity on release rate of tiaprofenic acid: a novel pharmacokinetic-pharmacodynamic model. AB - PURPOSE: To test the hypothesis that modification of release pattern of nonsteroidal anti-inflammatory drugs (NSAIDs) formulations shifts gastrointestinal (GI) toxicity of the drugs from the upper GI region to the distal intestine. METHODS: We assessed tiaprofenic acid (TA)-induced upper and lower increased GI permeability (a surrogate marker of toxicity) after administration of 20 mg and 40 mg/kg regular release (powder) and modified release formulations [sustained release (SR) beads and diethyl-beta-cyclodextrin (DCD):TA inclusion complex (INC)]. Urinary excretion of oral doses of GI permeability probes sucrose and 51Cr-EDTA was determined as measures of gastroduodenal and distal intestine, respectively. Pharmacokinetics of TA enantiomers were also studied following administration of a single 20 mg/kg dose of racemic TA as oral SR beads and iv solution. For powder and INC, previously reported pharmacokinetic data were used. RESULTS: Regular powder significantly increased the permeability at the gastroduodenal level. Modified-release formulations, on the other hand, did not cause damage in the gastroduodenum but produced significant increase in the permeability of the lower intestine. Consequently, to assess the pharmacokinetic-pharmacodynamic relationship, a new model was developed in which contribution of toxicity resulted from direct exposure to the drug was considered. CONCLUSIONS: Since the observed site of GI damage corresponds to the site of release and absorption of NSAID from the formulation, the possibility of a shift in the site of damage must be considered for the modified release formulations. A parallel evaluation of upper and lower GI toxicity is essential for a complete assessment of NSAID-induced GI damage. PMID- 9950291 TI - Use of truncated areas to measure extent of drug absorption in bioequivalence studies: effects of drug absorption rate and elimination rate variability on this metric. AB - PURPOSE: To compare the applicability and accuracy of truncated area (AUCt; where t represents truncated time) versus area to the last quantifiable time point [AUC(O-T)] for assessing bioequivalence. Drugs with either very low or very high intra-subject variability in clearance (CL) were selected for study. Clearance variability was defined by the number of subjects with a quantifiable plasma value (Cp) at each collection time from 24 hrs to last collection time (T). METHODS: Data for amiodarone and danazol, drugs with different distributions of subject CL were examined. For amiodarone, the number of subject samples observed (test + reference) at the time of the last quantifiable concentrations was 60 at 240 hrs(T), 16 at 144 hrs and 4 at 96 hrs: while danazol had 4 at 96 hr(T), 3 at 72 hrs, 16 at 60 hrs, 7 at 48 hrs, 14 at 36 hrs, 11 at 24 hrs, 13 and 2 at 16 and 12 hrs, respectively. Simulations (Scenarios A and B) were performed to obtain populations (N = 24) with CL patterns similar to those of amiodarone and danazol. For scenario A (CL pattern similar to amiodarone), log-normally distributed CL values (28.8 L/HR) with intra-subject coefficient of variation (CV) of 25%, 40% and 60% gave the desired CL pattern. Scenario B (CL pattern similar to danazol) required that a subpopulation with an increase in CL of 40% from baseline (i.e., 40.32 L/HR) in 5%, 10% and 20% of the population represent the desired distribution. Power was evaluated by the percentage of times the simulated trials were declared bioequivalent (i.e., the number of times the test vs. reference 90% CI was within 80-125%), while accuracy was determined when the true difference in fraction absorbed (i.e., 1.25) was within the CI. Each simulation was repeated 300 times. RESULTS: The simulation results for Scenario A indicated that the statistical results using truncated area (AUCt) had power and accuracy equivalent to that obtained using the AUC(O-T) metric. However, results for Scenario B indicated that AUCt had less power and accuracy than that obtained using AUC(0 T). The confidence interval (CI) for amiodarone was the same whether AUC (0-T) or AUCt was used as the metric for extent, while for danazol, the AUC(0-T) and AUCt differed in the lower limit by 7%. CONCLUSIONS: The truncated area, AUCt, has the greatest power and accuracy when the population clearance is such that most subjects have measurable plasma concentrations at last collection time(T), resulting in a proportional loss of data from each subject. PMID- 9950292 TI - The effect of excipients on the molecular mobility of lyophilized formulations, as measured by glass transition temperature and NMR relaxation-based critical mobility temperature. AB - PURPOSE: The dependence of the molecular mobility of lyophilized formulations on pharmaceutical polymer excipients was studied. Molecular mobility as determined by NMR relaxation-based critical temperature of molecular mobility (Tmc) and glass transition temperature (Tg) is discussed in relation to the plasticizing effect of water in formulations. METHODS: The Tmc and Tg of lyophilized gamma globulin formulations containing 6 different polymer excipients such as dextran, polyvinylpyrrolidone (PVP) and methylcellulose (MC) was determined by NMR and DSC. The molecular mobility of water in the formulations was determined by proton NMR and dielectric relaxation spectrometry (DRS). RESULTS: Tmc varied with polymer excipients. Tmc increased as the ratio of bound water to mobile water increased and as the molecular mobility of mobile water decreased. The formulation containing MC exhibited a lower Tmc than the formulation containing dextran because of the smaller ratio of bound water and the higher molecular mobility of mobile water. The Tmc of the formulation containing PVP was higher than that expected from the higher T2 values of water because of the lower molecular mobility of mobile water regardless of the higher ratio of mobile water. The Tmc of these lyophilized formulations was higher than their T(g) by 23 degrees C to 34 degrees C, indicating that the formulations became a NMR-detected microscopically liquidized state below their T(g). CONCLUSIONS: The quantity and the molecular mobility of mobile water in lyophilized formulations can be considered to affect the T(mc) of lyophilized formulations, which in turn governs their stability. PMID- 9950293 TI - Molecular mechanisms of the adsorption of a model protein (human serum albumin) on poly(methylidene malonate 2.1.2) nanoparticles. AB - PURPOSE: To understand the molecular mechanisms involved in protein-methylidene malonate 2.1.2 polymer interactions. METHODS: To assess the importance of electrostatic forces in polymer-protein interactions use was made of HSA and its derivatives, which were anionized by succinylation and aconitylation. Surface plasmon resonance measurements, using the three HSA molecules as immobilized ligands and polymer nanoparticles as analytes in the liquid phase, allowed the determination of initial kinetic constants and affinity constants at equilibrium at two different temperatures. RESULTS: Saturation of binding for the three proteins occurred at approximately 900 protein molecules/nanoparticle. The apparent affinity decreased with increasing electronegativity of the proteins. Surface plasmon resonance measurement of proteins, covalently linked to the chip matrix, showed a high affinity for the nanoparticles (K(A) approximately 10(10) M(-1) and confirmed the moderate decrease of affinity with increasing electronegativity of the modified albumins. Measurements at 25 and 37 degrees C showed no significant increase in the albumin-nanoparticle interactions. Dissociation of the proteins from the nanoparticles could only be realized with chaotropic salt solutions. CONCLUSIONS: These results suggest the molecular forces initiating the protein-nanoparticle interactions are mainly of electrostatic nature followed by stabilization by hydrophobic forces. The high affinity confirms the nanoparticles as excellent carriers for protein delivery. PMID- 9950294 TI - Novel bioresorbable and bioeliminable surfactants for microsphere preparation. AB - PURPOSE: The objective of this work is to prepare microspheres by the emulsion solvent evaporation process using MPOE-PLA copolymers as the matrix material and/or the surfactant. This preparation was studied in order to avoid the use of PVA as the surfactant in the process. METHODS: Two series of MPOE-PLA copolymers were synthesised. The first, with a long and constant length PLA chain (45,000 g.mol(-1), was used as the matrix material, the second, with short PLA chains (< or = 2.200 g.mol(-1)), and different HLB as the surfactant. Microspheres were prepared by the "simple" and "double" emulsion methods. The steric stabilization effect of the copolymers was investigated using confocal microscopy and X-ray photoelectron spectroscopy (XPS). RESULTS: Confocal microscopy and XPS analysis showed that the microspheres prepared using MPOE5K-PLA0.5K as the surfactant and MPOE-PLA45K copolymers as the matrix material had an MPOE coating present at the microsphere surface. This hydrophilic layer ensures steric stabilization of the particles. CONCLUSIONS: MPOE-PLA copolymers can be used for the preparation of particles instead of PVA and their use can be extended whenever a biocompatible and bioeliminable surfactant is required for biological or medical applications. PMID- 9950296 TI - Electrochemical generation and interaction study of the nitro radical anion from nimesulide. PMID- 9950295 TI - A novel formulation of VIP in sterically stabilized micelles amplifies vasodilation in vivo. AB - PURPOSE: To determine whether human vasoactive intestinal peptide (VIP) poly(ethylene glycol) (PEG)-grafted distearoyl-phosphatidylethanolamine (DSPE) micelles elicit potent and stable vasodilation in vivo. METHODS: PEG-DSPE micelles were prepared by co-precipitation. VIP was loaded into micelles by incubation at room temperature. Vasoactivity of VIP in SSM was determined by monitoring changes in diameter of resistance arterioles in the in situ hamster cheek pouch using intravital microscopy. RESULTS: VIP easily undergoes self assembly into small PEG-DSPE micelles (mean [+/-SEM] size, 18+/-1 nm) in a time dependent fashion. This generates a potent vasoactive matrix at nanomole concentrations of VIP as manifested by approximately 3-fold potentiation and prolongation of vasodilation relative to that evoked by aqueous VIP alone (p < 0.05). This response is specific and mediated by the L-arginine/nitric oxide (NO) biosynthetic pathway. Micellar VIP dispersion remains vasoactive for at least 14 days after preparation and storage at 4 degrees C. CONCLUSIONS: A novel, self associated, small and stable PEG-DSPE micellar formulation of VIP amplifies vasodilation in the in situ peripheral microcirculation in a specific fashion by elaborating NO. An optimized formulation could be considered for certain cardiovascular disorders associated with L-arginine/NO biosynthetic pathway dysfunction. PMID- 9950297 TI - A comparison of step-gradient and sequential density ultracentrifugation and the use of lipoprotein deficient plasma controls in determining the plasma lipoprotein distribution of lipid-associated nystatin and cyclosporine. PMID- 9950298 TI - Accuracy and precision of pharmacodynamic exponent. PMID- 9950299 TI - Day-care and otitis media in young children: a critical overview. AB - To review the evidence concerning the association between (different forms of) day-care and otitis media in children aged 0-4 years, we performed a meta analysis of studies identified by a systematic search with Medline from 1966 to July 1997 and by the reference lists. Seventeen articles were classified as useful because these articles studied children of 0-4 years of age and because odds ratios as well as confidence intervals were presented or could be calculated. All these studies found a association between attending a day-care centre and otitis media. The association between otitis media and family care was less clear. Differences in study design, age of the subjects, and controlled variables did not explain the association. CONCLUSION: Day-care is a risk factor for developing otitis media: the number of children seems to be important for this effect, probably due to increased exposure to otitis media pathogens. PMID- 9950300 TI - Prevalence of complementary/alternative medicine for children: a systematic review. AB - Complementary/alternative medicine (CAM) has become an important topic, not least because of its popularity with patients. This systematic review is aimed at summarising the data known about CAM use in paediatric populations. A thorough search strategy was designed to identify all surveys on the prevalence of CAM utilisation in children. Data from those investigations that met the pre-defined criteria for inclusion were extracted and reported in a standardised fashion. Ten studies were found. Their results suggest that the prevalence of CAM use is variable but generally high. CAM is often perceived as helpful. Insufficient data exist about safety and cost. CONCLUSION: The generally high and possibly growing prevalence of complementary/alternative medicine use by children renders this topic an important candidate for rigorous investigation. In particular, we should determine the efficacy, safety and expense of these treatments through rigorous, unbiased investigations. PMID- 9950301 TI - Parental attitude towards alternative medicine in the paediatric intensive care unit. AB - The interest in alternative medicine (AM) is growing. In the USA and Canada, studies showed that 34% of adults and 11% of children use AM. In a prospective cohort study, we investigated the interest in AM among parents of critically ill children in the paediatric Intensive Care Unit (ICU) of a university hospital. From January 1996 to April 1997, we distributed questionnaires to the parents of critically ill children. These strictly anonymous questionnaires were completed at home and returned by mail. Exclusion criteria were short ( < 1 day) or repeated hospitalizations, and insufficient proficiency of the German language. The inclusion criteria were fulfilled by 591 patients; 561 received the questionnaire (95%) and 289 (52%) were returned. Of the respondents, 70% would appreciate AM as a complementary therapy on the ICU, 23% found AM equally or more important than conventional medicine whereas only 7% regarded AM as unimportant. On the ICU, 18% used AM; surprisingly 41% of them did not discuss it with physicians or nurses. An additional 21% would have liked to use AM, but did not do so. Typically, AM-users administered AM also at home to their children and themselves. Their children were however, older. CONCLUSIONS: A substantial proportion of parents used measures of alternative medicine in the intensive care unit, or would have like to do so. However, few had the confidence to discuss this wish with the medical personal. This suggests that alternative medicine is of great interest, even on an intensive care unit. Nevertheless, discussion about alternative medicine seems to be taboo in doctor-patient relations. PMID- 9950302 TI - Angiotensin I converting enzyme and angiotensinogen gene polymorphisms related to 24-h blood pressure in paediatric type I diabetes mellitus. AB - The aim of this study was to evaluate two putative predictive genetic markers for hypertension in children and adolescents with diabetes mellitus. Ambulatory blood pressure measurements were performed in 199 patients with type I diabetes mellitus (mean age 16.5 years, mean duration of diabetes 7.7 years) and compared to those of 1141 healthy children. The local allele frequencies were established based on a control population consisting of 181 healthy subjects. The allele frequencies of the angiotensinogen gene M235T polymorphism was nearly identical in insulin-dependent diabetes mellitus patients (MM 33%, MT 51%, TT 16%) and controls (MM 35%, MT 49%, TT 16%). In contrast, the genotype distribution of the angiotensin I converting enzyme gene insertion/deletion (I/D) polymorphism was different between patients with type I diabetes mellitus (DD 26%, ID 49%, II 25%) and the control group (DD 37%, ID 44%, II 19%) (P=0.04). Relative nocturnal systolic and diastolic pressures in patients with diabetes were higher than in healthy age- and height-matched controls; no association was found with the angiotensinogen gene M235T polymorphism. Relative nocturnal diastolic blood pressure was higher in patients homozygous for the I allele of the angiotensin I converting enzyme gene. CONCLUSION: Nocturnal systolic and diastolic blood pressure is higher in patients with type I diabetes than in healthy children. The formerly described, but controversial, association of the M235T polymorphism with arterial hypertension could not be confirmed in this study. PMID- 9950303 TI - Thyroid antibodies in children of mothers with auto-immune thyroid disease. AB - In a cross-sectional study, 29 children aged between 1 month and 15.3 years (average age 6.8 years) born to mothers with Graves disease or Hashimoto thyroiditis were examined clinically, biochemically, and by sonography of the thyroid gland. At the time of examination all children were clinically euthyroid. Tests of thyroid peroxidase antibody, thyroglobulin antibody, TSH receptor antibody and free thyroxine (fT4) gave normal results. In 3 children subclinical hypothyroidism with elevated TSH and normal fT4 concentrations were found; one of these children had a minor decrease of total thyroxine. Three children with otherwise normal test results had marginally elevated triiodothyronine concentrations. Increased antibody titres were present in 8 out of 29 children. TSH function-blocking antibodies were elevated in 8 cases. In addition, cytotoxic antibodies were found in one of the children. The distribution pattern of antibodies was different in each child and unrelated to the type of maternal thyroid disease. CONCLUSION: Children of mothers with auto-immune thyroid disease often have thyroid antibodies without signs of thyroid disease. Whether antibody positive children have an increased risk of developing thyroid disorders later in life must be examined in a longitudinal study. PMID- 9950304 TI - Computed tomography scan assessment of lung disease in primary immunodeficiencies. AB - A wide spectrum of lung disease can complicate primary immunodeficiencies and early recognition influences management and prognosis. Computed tomography (CT) especially high resolution computed tomography (HRCT) has been shown to detect lung disease in adult immunodeficient patients often when the chest radiograph (CXR) is normal, but this has not been studied in children. Twenty-five CT scans [10 HRCT] and CXRs were reviewed in 23 children [14 male, 9 female] with primary immunodeficiency. Eighteen [72%] of the CT scans were abnormal, bronchiectasis being the commonest finding present in eight CT scans in patients with antibody deficiency. In eight cases CT scan revealed changes not seen on CXR (bronchiectasis; interstitial changes; small parenchymal nodules; air trapping;and a small upper lobe cyst) which influenced treatment in six cases. CONCLUSION: CT scans have a valuable role in assessing lung disease in children with primary immunodeficiencies and will detect important changes not visible on CXR. PMID- 9950305 TI - Isoprinosine does not protect against frequent respiratory tract infections in childhood. AB - Isoprinosine, an in vitro immuno-enhancing agent principally acting by stimulating T-lymphocytes, is one of a number of agents sometimes used in an attempt to prevent recurrent respiratory infections in children, although there are no formal trials for this particular drug. We performed a placebo-controlled double-blind trial to assess the efficacy of isoprinosine (50 mg/kg per day) for 6 weeks followed by 50 mg/kg per day twice weekly for 6 weeks in the prevention of frequent acute respiratory tract infections in 102 children aged 4-8 years. A total of 43 children treated with isoprinosine and 41 with placebo finished the study. Despite a transient increase in the total number of CD3+, CD4+ and CD8+ T lymphocytes after 6 weeks of daily isoprinosine treatment, there was no difference in the number and length of duration of acute respiratory infections, number of antibiotic courses and number of days with cough, pharyngitis, rhinitis and increased body temperature (> or = 37.0 degrees C and > or = 38.0 degrees C). There were no changes in markers of T- or B-lymphocyte activation (CD25, HLA-DR, CD45RA/RO, CD23). CONCLUSION: Attempts at immunomodulation using isoprinosine in the dose and for the duration used may increase the total numbers of both CD4 and CD8 T-lymphocytes but is ineffective in prevention of respiratory tract infections in childhood. PMID- 9950306 TI - The role of acoustic rhinometry in the diagnosis of adenoidal hypertrophy in pre school children. AB - Adenoidal hypertrophy is a common problem in pre-school children and diagnosis depends mostly on evaluation of clinical symptoms and signs. Investigative techniques to assess adenoidal size often do not add to this information. Recent reports have suggested a role for acoustic rhinometry in this situation. A total of 49 children consecutively referred to the Department of Otorhinolaryngology, University of Mainz, with evidence of adenoidal enlargement underwent acoustic rhinometry pre- and post-operatively and were compared to an age-matched control group from a local kindergarten school. Adenoidal size was visually estimated at surgery and questionnaires were completed by parents of symptomatic children. Acoustic rhinometry was not able to differentiate controls (mean nasopharyngeal cross-sectional area 1.34+/-0.47 cm2, n = 35) from symptomatic children admitted for adenoidectomy (mean nasopharyngeal cross-sectional area 1.66 +/- 0.83 cm2, n = 42, P = 0.53). Acoustic rhinometry was advantageous for patients with adenoidal hypertrophy in two situations. Firstly a sub-group of patients with complete nasopharyngeal obstruction could be identified (P = 0.03) and secondly all patients with a postnasal space less than 1.2 cm2 clinically benefited from adenoidectomy. CONCLUSIONS: Acoustic rhinometry, in general, is not suitable for assessing adenoidal size in pre-school children. Physical limitations of currently available acoustic rhinometers are likely to explain the limited clinical value of this investigative technique. PMID- 9950307 TI - Use of permissive hypercapnia in the ventilation of infants with respiratory syncytial virus infection. AB - We wished to retrospectively evaluate the effects of permissive hypercapnia (PHY) on barotrauma, mortality and length of stay when applied to ventilated infants with respiratory syncytial virus (RSV) bronchiolitis. Nineteen control infants with RSV induced respiratory failure were treated with conventional ventilation (April 1991-January 1994), after which time PHY was adopted as unit policy. A further 28 infants were then treated with PHY (January 1994 April 1996). Demographic and physiological data were collected from admission, and outcome variables including length of stay, barotrauma and mortality were recorded. The PHY group showed a significantly higher mean pCO2 (7.6 vs 5.2 kPa), a lower mean pH (7.34 vs 7.40), and a reduction in maximal peak inspiratory pressures (25 vs 30 cmH2O). Mortality, barotrauma, use of neuromuscular blockade and nosocomial infection did not differ between groups. There was a trend towards increased length of ventilation in the PHY group (median 7 vs 5 days). CONCLUSION: Based on this retrospective data we can show no benefit for the use of permissive hypercapnia as a ventilatory strategy in this patient group. A prospective randomised controlled trial is warranted to accurately assess the outcome variables and cost implications of this strategy. PMID- 9950308 TI - Rationale for the German recommendations for phenylalanine level control in phenylketonuria 1997. AB - Treatment of hyperphenylalaninaemias due to phenylalanine hydroxylase deficiency with a low phenylalanine (Phe) diet is highly successful in preventing neurological impairment and mental retardation. There is consensus that, for an optimal outcome, treatment should start as early as possible, and that strict blood Phe level control is of primary importance during the first years of life, but for adolescent and adult patients international treatment recommendations show a great variability. A working party of the German Working Group for Metabolic Diseases has evaluated research results on IQ data, speech development, behavioural problems, educational progress, neuropsychological results, electroencephalography, magnetic resonance imaging, and clinical neurology. Based on the actual knowledge, recommendations were formulated with regard to indication of treatment, differential diagnosis, and Phe level control during different age periods. The development of the early-and-strictly-treated patient in middle and late adulthood still remains to be investigated. Therefore, the recommendations should be regarded as provisional and subject to future research. Efficient treatment of phenylketonuria has to go beyond recommendations for blood Phe level control and must include adequate dietary training, medical as well as psychological counselling of the patient and his family, and a protocol for monitoring outcome. CONCLUSIONS: Early-and-strictly-treated patients with phenylketonuria show an almost normal development. During the first 10 years treatment should aim at blood Phenylalanine levels between 40 and 240 micromol/L. After the age of 10, blood phenylalanine level control can be gradually relaxed. For reasons of possible unknown late sequelae, all patients should be followed up life-long. PMID- 9950309 TI - The neurogenic weakness, ataxia and retinitis pigmentosa (NARP) syndrome mtDNA mutation (T8993G) triggers muscle ATPase deficiency and hypocitrullinaemia. AB - Based on the study of three unrelated families, we report what we believe to be the first in vivo evidence of muscle ATPase deficiency in individuals carrying the neurogenic weakness, ataxia and retinitis pigmentosa (NARP) syndrome mtDNA mutation (T8993G). Since plasma citrulline was consistently low in 4/5 patients, we suggest that the NARP mutation caused complex V deficiency in the small intestine as well, thus reducing the availability of mitochondrial ATP required for citrulline synthesis. CONCLUSION: We suggest giving consideration to hypocitrullinaemia as a hallmark of the neurogenic weakness, ataxia and retinitis pigmentosa syndrome mutation and more generally of impaired oxidative phosphorylation in the small intestine in vivo. PMID- 9950310 TI - Predicting length-of-stay in preterm neonates. AB - In neonatology, the early prediction of length-of-stay (LOS) may help in decision making. We retrospectively studied the accuracy of two LOS prediction models, namely a multiple linear regression model (MR) and an artificial neural network (ANN). Preterm neonates (n = 2144) were randomly assigned to a training-and-test (75%), or validation patient set (25%). A total of 40 first-day-of-life items (input data) and the date of discharge (output data) were routinely available. Training-and-test set data were used to identify input items with impact on LOS (input variables) using MR analysis to establish a MR prediction model and to train and test an ANN on those selected variables. Fed with validation set data, predicted LOS obtained from MR and ANN was compared individually with actual LOS. Predicted and actual LOS were highly correlated (for MR, r = 0.85 to 0.90; for ANN, r = 0.87 to 0.92). CONCLUSION: Even first-day-of-life data may contain substantial information with which to predict individual length-of-stay. PMID- 9950311 TI - Comparison of sucrose and human milk on pain response in newborns. AB - The aim of this study was to compare the analgesic effect of 2 ml 25% sucrose and human milk in a group of healthy term newborns. Healthy infants (n = 102) were randomly allocated to receive one of three solutions (sucrose, human milk, sterile water) 2 min prior to taking a heel prick blood sample. The median values of crying time, recovery time and percentage change in heart rate at 1, 2 and 3 min were recorded in response to the heel prick. Median crying times were 36, 52, and 62 s in the sucrose, placebo and human milk groups, respectively (P = 0.0009). In the sucrose group, there was a significant reduction in crying time compared to human milk and placebo groups. Similarly, the median recovery time in the sucrose group (72 s) was shorter than that in the human milk (112 s) and placebo groups (124 s) (P = 0.004). The percentage change in heart rate at 1, 2 and 3 min was also significantly lower in the sucrose group (P = 0.008, P = 0.01, P = 0.002 at 1, 2, and 3 min respectively). CONCLUSION: The orosensorial antinociceptive effect of human milk is not as effective as an analgesic as a 25% sucrose solution. PMID- 9950312 TI - Necrotising enterocolitis: is there a relationship to specific pathogens? AB - Outbreaks of necrotising enterocolitis (NEC) have often been related to specific pathogens such as Enterobacteriaceae. This relationship, however, remains uncertain because of the retrospective nature of the studies addressing this issue. We performed a prospective study to investigate whether there is indeed an association between NEC and specific pathogens. Between April 1993 and March 1997, stools of neonates of < 36 weeks admitted to our neonatal unit were investigated for bacteria in weekly intervals. Clinical and bacteriological data from each infant who developed NEC were compared with those from two control infants matched for gestational age and date of admission. Eighteen infants developed 19 episodes of NEC (clinical signs + air in portal vein); 8 of these had laparotomy; two died. Occurrences of NEC were homogeneously distributed over the 4-year study period. The only significant differences in the clinical course prior to NEC were a more severe stage of respiratory distress syndrome [median 2 (0-4) vs. 0 (0-3), P < 0.05] and a higher proportion of infants who had only been formula fed (63 vs. 32%, P < 0.05) in the cases. Within the last week prior to NEC, potentially pathogenic bacteria were identified in stools of all cases and 79% of controls (P < 0.05). However, there was no significant difference in the occurrence of specific pathogens or groups of pathogens in cases compared with controls. CONCLUSION: Although gut colonisation with potential pathogens appeared to be a prerequisite for the development of NEC, there were no specific bacteria associated with this disease if data from infants with NEC were compared with those from time- and gestational age-matched controls. PMID- 9950313 TI - Neonatal neutropenia associated with maternal hypertension poses a risk for nosocomial infection. AB - One hundred and six neonates of 24-32 weeks gestation born to hypertensive mothers and 106 concurrent control infants of normotensive mothers were evaluated to determine the relationship between maternal hypertension and neonatal neutropenia and the risk of nosocomial infection developing in neutropenic infants. Complete blood counts were performed on both cohorts and retrospectively evaluated. Neutropenia was diagnosed using published reference ranges for infants with birth weight <1500 g and > 1500 g. Evidence of nosocomial infection based on a positive blood culture with supportive clinical signs of sepsis was documented. The incidence of neutropenia among infants of hypertensive mothers was not significantly different from that among infants of normotensive mothers (21% vs 24%), but the duration of neutropenia was significantly longer in the infants of hypertensive mothers (P = 0.0001). Nosocomial infection was more frequent in neutropenic than the non-neutropenic hypertensive mothers' infants (55% vs 12%, P = 0.0002). CONCLUSION: Although there is no difference in the incidence of neonatal neutropenia between infants of hypertensive mothers and those of normotensive mothers, the former group has an increased risk of nosocomial infection in neutropenic infants of hypertensive mothers. This may be related to prolonged neutropenia which was found in these infants in the present study. PMID- 9950314 TI - Successful stenting of congenital bronchial stenosis in infancy. AB - Recently, stent implantation has become the treatment of choice for patients with tracheobronchial stenosis due to malignant tumours, tuberculosis and recurrent stenosis following lung transplant. However, reports on this procedure in infants with congenital bronchial stenosis are extremely rare. We report successful stent implantation in an infant with congenital left bronchial stenosis followed by rapid improvement in his respiratory condition. CONCLUSION: The use of a stent in infants is still controversial because size mismatch will take place with growth. However, we believe that implantation of a metallic stent can be the preferred treatment of congenital bronchial stenosis even in small infants. PMID- 9950315 TI - A 30-month-old child with systolic murmur and temporal bruit. PMID- 9950316 TI - Fibronectin and meningococcal disease. PMID- 9950317 TI - Maternal phenylketonuria in two Sicilian families identified by maternal blood phenylalanine level screening and identification of a new phenylalanine hydroxylase gene mutation (P407L) PMID- 9950318 TI - Diagnosing bleeding Meckel diverticulum in children. PMID- 9950319 TI - Childhood Haemophilus influenzae type b meningitis in Russia. PMID- 9950320 TI - Genotypic and phenotypic resistance under zidovudine and lamivudine therapy in human immunodeficiency virus-infected children. PMID- 9950321 TI - A child with eosinophilic bronchopneumonia. PMID- 9950322 TI - Cure of latex allergy by bone marrow transplantation. PMID- 9950323 TI - Immune responses in chickens against Eimeria tenella sporozoite antigen. AB - Two-day old broiler chicks were subcutaneously immunized with Eimeria tenella sporozoite antigen (25 microg per chick) with or without adjuvants on 2 and 18 days of age and the effect of induced immunity was determined by challenging the chickens with 10(4) homologous sporulated oocysts at 32 days of age. Chicks immunized with sporozoite antigen emulsified in Freund's Complete Adjuvant (FCA) showed protection in terms of oocyst production, mortality and mean lesion scores. Antigen emulsified in FCA produced significant cell mediated immune responses (as assessed by lymphocyte migration inhibition test) from 12 to 30 days post-immunization. Antibody responses as assessed by enzyme linked immunosorbent assay were significant from 12 days postimmunization when the antigen was administered with or without adjuvants by subcutaneous route. PMID- 9950324 TI - Epidemiological patterns of canine leishmaniasis [correction of leishmaniosis] in Western Liguria (Italy). AB - An epidemiological survey was carried out on the distribution of canine leishmaniasis in Western Liguria (Northern Italy). Blood sera from 21146 dogs collected from 1990 to 1996 were subjected to the indirect immunofluorescence test (IFAT). From 1990 to 1994 (16690 dogs), only monthly seroprevalences were calculated (min 14%-max 60.5%). Dog sera sampled from October 1994 to May 1996 (4456 dogs) were divided into two subgroups (I: October 1994-May 1995; II: October 1995-May 1996). Seroprevalence was 30.3% and 22.1% in these two groups, respectively. Data analysis by log-linear models revealed that serological positivity to Leishmania sp. was significantly associated with a dog's outdoor lifestyle, with a rural environment and with the male sex. Of the 218 dogs which were tested twice seroconversion rates were also higher in outdoor, rural and male dogs while negativization rates were lower in the same groups. Basic reproductive numbers (R0) were 1.53 (subgroup I) and 1.28 (subgroup II). PMID- 9950325 TI - Experimental Cochlosoma anatis infections in poultry. AB - Cochlosoma anatis [Kotlan, A., 1923. Zentralbl. Bakteriol. Parasitenkd. Infektienskr. Hyg. 90, pp. 24-28] is a flagellated protozoan parasite of birds. We have encountered C. anatis in turkeys with enteritis. Experimental oral inoculations of turkeys with 1 x 10(6) to 10 x 10(6) trophozoites consistently reproduced infections in recipients. Trophozoites were most numerous in the jejunum and ileum but could be observed in the duodenum, ceca, colon, and feces. When 12 naive turkeys were placed on contaminated litter vacated by excreting turkeys only one of 12 became infected. When eight naive turkeys were placed in boxes with birds currently excreting trophozoites, seven of eight became infected. Trophozoites could not survive exposure to water or to freezing. Attempts to culture trophozoites in modified Diamond's medium, Kiester's medium, RPMI 1640 medium with 10% fetal bovine serum, or on cultured bovine turbinate cells were not successful. Four of six bobwhite quail and one of eight chickens orally inoculated with 10 x 10(6) to 20 x 10(6) trophozoites had detectable infections. Trophozoites were observed only in the ilea of bobwhite quail and the ceca of the positive chicken. Trophozoites collected from chickens and bobwhite quail remained infectious for turkeys. PMID- 9950326 TI - The effectiveness of benzimidazole derivatives for the treatment and prevention of histomonosis (blackhead) in turkeys. AB - The benzimidazole derivatives, albendazole and fenbendazole were evaluated for their effectiveness in the treatment and prevention of histomonosis (blackhead) in turkeys. Histomonosis was produced in 5 week-old birds by placing them on broiler breeder litter known to be contaminated with Heterakis gallinae ova and the protozoan Histomonas meleagridis. In the first trial, at the onset of confirmed clinical disease, birds were treated orally with metronidazole, a compound known to be effective against Histomonas. Those receiving metronidazole had significantly greater mean body weight gains during the treatment period and the 2 weeks following treatment than untreated controls. Treated birds also had significantly lower caecal and liver lesion scores. These findings served to validate the method of disease reproduction and establish its suitability for testing the benzimidazoles. Similar trials were conducted to determine the therapeutic value of albendazole at 100.0 mg/kg of body weight and fenbendazole at 10.0 mg/kg body weight, administered orally twice a day for 5 consecutive days. Under these conditions, both drugs were found to be ineffective as treatments. A final trial was conducted to assess the prophylactic value of albendazole and fenbendazole administration. At the time of placement on contaminated litter, birds were medicated as previously described with the exception that treatment was continued for 14 consecutive days, the approximate incubation period for histomonosis. The trial was terminated on the 16th day. In the case of both albendazole and fenbendazole, treatment was associated with a significant increase in mean body weight gain and lower caecal and liver lesion scores. It is believed that the observed prophylactic effect may be attributed to the destruction of the transport vector e.g., Heterakis larvae, or to direct killing of the flagellated form of Histomonas which is normally found in the caecal lumen and is considered to be more sensitive to chemotherapeutic agents than the amoeboid form found in tissues. PMID- 9950327 TI - Biological control of nematode parasites of livestock in Fiji: screening of fresh dung of small ruminants for the presence of nematophagous fungi. AB - Approximately 2500 faecal samples were collected per rectum from sheep and goats from 26 farms located on four of the Fijian islands where most of the small ruminants in this country are raised. The purpose was to screen these samples to isolate nematode-trapping fungi that had been acquired by these animals during the course of their feeding and which had remained viable following passage through their gastrointestinal tract. From these samples, 23 examples of nematophagous fungi were noted in the initial appraisal, from which 12 pure isolates (all of the genus Arthrobotrys) were made. A number factors emerged from this work which may have restricted the opportunities in which nematophagous fungi were detected, or isolated. PMID- 9950328 TI - Comparison of pharmacokinetic profiles of doramectin and ivermectin pour-on formulations in cattle. AB - The plasma pharmacokinetics of doramectin and invermectin after topical administration (500 microg kg(-1)) were compared over a 50-day period in 24 young beef cattle. Observed maximum concentration (Cmax) and time to maximum concentration (Tmax) were determined directly from plasma concentrations for each animal. The area under the plasma concentration-time curve (AUC) and mean residence time (MRT) were calculated as indices of drug exposure and persistence. The Cmax of doramectin (12.2+/-4.8 ng ml(-1)) and ivermectin (12.2+/-6.0 ng ml( 1)) and Tmax of doramectin (4.3+/-1.6 days) and ivermectin (3.4+/-0.8 days) were not significantly different (p > 0.05). In contrast, the AUC of doramectin (168.0+/-41.7 ng day ml(-1)) was significantly greater than that of ivermectin (115.5+/-43.0 ng day ml(-1)). Furthermore, the range of AUC values calculated for ivermectin was wider than that obtained for doramectin, extending from 51.3 to 182.3 ng day ml(-1) for ivermectin versus 104.3-228.7 ng day ml(-1) for doramectin. The MRT was significantly greater for doramectin (12.8+/-1.9 days) than for ivermectin (8.4+/-1.5 days). It was concluded that a 500 microg kg(-1) pour-on administration of doramectin and ivermectin led to an overall exposure as reflected by the mean AUC, that was 45% higher for doramectin compared to ivermectin and that the relative inter-individual variability was less for doramectin than for ivermectin. Possible therapeutic consequences of these differences between doramectin and ivermectin pour-on formulations are discussed. PMID- 9950329 TI - Detection of Trichinella infection in slaughter horses by ELISA and western blot analysis. AB - In order to determine the presence of Trichinella infections in horses slaughtered at an abattoir in Mexico, 147 serum samples were examined by two immunoenzymatic methods. Specific antibodies were detected by ELISA in 7% of the serum samples at a dilution 1:400 and in 10% at lower dilutions (1:20, 1:40) using Trichinella spiralis muscle larvae (ML) excretory/secretory (E/S) products. Serum samples from four naturally infected horses (confirmed by direct methods) gave negative O.D. values in an ELISA at a 1:400 dilution and only two of them were positive at a 1:20 and 1:40 dilutions. Serum samples from experimentally infected horses reacted by Western blotting with ML components with molecular weights of 47, 52, 59, 67, 72 and 105 kDa which correspond to the TSL-1 antigens. Serum samples from the four naturally infected horses and from the abattoir horses that were positive in ELISA using E/S antigens recognized several ML components, some of them reacted with all the TSL-1 antigens mentioned above and others recognized preferentially two or three of these molecules. Since the serologic assays may not offer the sensitivity required in the diagnosis of horses trichinellosis and the direct methods had not always been useful in the detection of larvae in horsemeat related to trichinellosis outbreaks in Europe, it is proposed that additional assays are performed to determine Trichinella infection in horses. These can include detection of parasite antigens by ELISA and Dot ELISA or PCR, which in turn may also help to determine the presence of the parasite in early and late infections of horses. PMID- 9950330 TI - Helminths from a stranded manatee in the Dominican Republic. AB - Endangered West Indian manatees (Trichechus manatus) are known to be parasitized by a number of helminths and ectoparasites. Records of parasitic associations exist for Florida, Mexico, Guyana, Brazil, Cuba and recently for Puerto Rico. Parasites of manatees in other Caribbean areas have not been documented, particularly from Hispaniola. We report on the occurrence of a species of nematode and of two trematodes from a 238-cm male manatee from Portillo (19 degrees 20' N, 69 degrees 35' W), Las Terrenas, in the Dominican Republic. Three species of helminths were collected, including the opisthotrematid Cochleotrema cochleotrema, the ascarid Heterocheilus tunicatus, and the paramphistomid trematode Chiorchis fabaceus. The documentation of these helminths constitutes the first record of these parasites and host relationships for Hispaniola and the second for the northeastern Caribbean. PMID- 9950331 TI - Geostatistics and remote sensing using NOAA-AVHRR satellite imagery as predictive tools in tick distribution and habitat suitability estimations for Boophilus microplus (Acari: Ixodidae) in South America. National Oceanographic and Atmosphere Administration-Advanced Very High Resolution Radiometer. AB - Remote sensing based on NOAA (National Oceanographic and Atmosphere Administration) satellite imagery was used, together with geostatistics (cokriging) to model the correlation between the temperature and vegetation variables and the distribution of the cattle tick, Boophilus microplus (Canestrini), in the Neotropical region. The results were used to map the B. microplus habitat suitability on a continental scale. A database of B. microplus capture localities was used, which was tabulated with the AVHRR (Advanced Very High Resolution Radiometer) images from the NOAA satellite series. They were obtained at 10 days intervals between 1983 and 1994, with an 8 km resolution. A cokriging system was generated to extrapolate the results. The data for habitat suitability obtained through two vegetation and four temperature variables were strongly correlated with the known distribution of B. microplus (sensitivity 0.91; specificity 0.88) and provide a good estimation of the tick habitat suitability. This model could be used as a guide to the correct interpretation of the distribution limits of B. microplus. It can be also used to prepare eradication campaigns or to make predictions about the effects of global change on the distribution of the parasite. PMID- 9950332 TI - The incidence and economic significance of ovine toxoplasmosis in Uruguay. AB - Antibodies to Toxoplasma gondii were measured before and after pregnancy in a 1:64 dilution of sera with the direct agglutination test in 1613 ewes from 18 farms in eight different counties of Uruguay from 1992 to 1994. The overall seroprevalence increased from 28.7% before mating to 38.5% after lambing in 2.5 years and thus the incidence was 9.8%. Losses due to toxoplasmosis during pregnancy were estimated to be 1.4-3.9% of the total number of ewes investigated, amounting to approximately US$1.4-4.7 million for the whole country. PMID- 9950333 TI - Detection of Cryptosporidium oocysts in wild mammals of mainland Britain. AB - This paper combines the results from a preliminary survey of occurrence of Cryptosporidium species in faecal samples from a range of wild mammal species inhabiting mainland Britain with a tabulated literature review of world-wide reports of the parasite in those British mammals. In the literature, C. parvum was reported from 11 wild mammals found in Britain and elsewhere, mainly in rodents but also in insectivores, lagomorphs and ungulates. C. muris has been reported only in wild rodents. The sample survey detected C. parvum in seven additional British species, including carnivores. Overall, 12% of 184 faecal samples tested with a genus-specific monoclonal antibody contained oocysts of C. parvum. The results further emphasise the widespread distribution of Cryptosporidium amongst wild mammals in Britain, highlight the potential for transmission between host species and warn of the possibility of direct exposure for anybody using the countryside for professional or recreational purposes (e.g. farmers and ramblers) to previously unregarded sources of infection. It seems increasingly likely that most, if not all, mammalian species can be infected with C. parvum. PMID- 9950334 TI - Drug resistance in Sudanese Trypanosoma evansi. AB - The drug sensitivities of 16 Trypanosoma evansi isolates from Sudan were examined using two different in vitro assays and rodent models. IC50 values (concentration which inhibited incorporation of 3H-hypoxanthine by 50%) obtained in a 40 h assay indicate that most of the isolates were resistant to suramin, a drug which has not been used in Sudan since 1975. Sensitivities for suramin in a 10-day-in vitro assay varied within a 124-fold range. The in vitro results were confirmed by infection/treatment experiments in mice. Sensitivities in vitro for quinapyramine varied within a 166-fold range. In mice, the least sensitive isolates were not cured with dosages up to 10 mg/kg quinapyramine. Based on in vitro results, all isolates appeared to be susceptible to isometamidium. PMID- 9950336 TI - Seroprevalence of Trichinella infection in domestic swine based on the National Animal Health Monitoring System's 1990 and 1995 swine surveys. AB - Swine sera collected by the US Department of Agriculture's Center for Animal Health Monitoring during 1990 and 1995 was tested for antibodies to Trichinella spiralis using an enzyme immunoassay. From a total of 3048 sera collected from lactating sows in 1990, five sera tested positive for a prevalence of 0.16%. From a total of 7987 sera collected from both finishing pigs and gestating sows in 1995, one serum was positive for a prevalence of 0.013%. Responses to questionnaires administered at the time of serum collection showed that seropositive farms had management variables consistent with known risk factors for exposure to trichinae. PMID- 9950335 TI - The effect of first season chemoprophylaxis in calves on second season pasture contamination and acquired resistance and resilience to gastrointestinal nematodes. AB - Two groups of second grazing season cattle, which had been treated with an ivermectin-sustained-release bolus (ISRB) in their first grazing season, were monitored during consecutive years (1995 and 1996) on the same second grazing season pasture. In the preceding year (1994), this pasture had been grazed by yearlings that had not received chemoprophylaxis in their first grazing season. The objectives of the study were, firstly, to investigate whether the chemoprophylactic-treated yearlings were less resistant to gastrointestinal nematodes upon subsequent exposure, and hence excreted more strongyle eggs compared to the control yearlings; secondly, whether an increased susceptibility of the previously treated animals resulted in a yearly increase of the pasture infestation on the second grazing season pasture; and finally, whether this affected the second year weight gain of the animals. In 1996, the yearlings that had been chemoprophylactic-treated in 1995 excreted higher numbers of nematode eggs, compared to the previously 'untreated' yearlings. In addition, the proportion of Cooperia larvae was markedly higher in the faecal cultures from the chemoprophylactic treated-animals, suggesting a negative effect of preventive treatment with an ISRB on the acquired resistance of the animals. However, there was no evidence that the slightly higher egg output in the previously treated yearlings had an effect on the larval contamination of the second grazing season pasture. A significant yearly decrease in the second season average daily weight gains was observed, but it could not be inferred from the results of the parasitological parameters that the differences in second year growth were caused by different levels of resilience between chemoprophylactic-treated and untreated animals. As the study covered three consecutive second grazing seasons, an effect of differences between years (e.g. in weather conditions or grass growth) on the results cannot be excluded. PMID- 9950337 TI - Nematode burdens and cellular responses in the abomasal mucosa and blood of Florida Native, Rambouillet and crossbreed lambs. AB - This experiment was carried out to compare the worm burden and cellular responses in the abomasal mucosa and blood of Florida Native and Rambouillet lambs and also in animals produced by crosses of these two breeds (generations F1 and F2). Animals were exposed to infection by gastrointestinal nematodes on three different occasions. The first infection was natural, occurring while they were suckling lambs. After weaning, they were kept indoors for 53 days and then were allowed to graze a contaminated pasture for 50 days for a second natural infection. The third infection was an artificial challenge with 6000 Haemonchus contortus infective larvae. The highest mean fecal egg counts (FEC) values were found in Rambouillet lambs followed in decreasing order by F1, F2 and Florida Native lambs. Throughout the trial, most of the high mean packed cell volumes and plasma protein levels were recorded in the F2 lambs; in contrast, most of the low values were found in the Rambouillet lambs. During the natural infection period, the highest percentages of larvae in the fecal cultures of the lambs were Haemonchus. However, high percentages of Trichostrongylus larvae were found particularly in Florida Native lambs. The mean number of blood eosinophils increased after the artificial challenge, reached a peak 21 days after infection and then declined. The highest and lowest blood eosinophil means were recorded in F2 and Florida Native lambs, respectively. The H. contortus burden was significantly higher in Rambouillet and in F1 lambs than in Florida Native and F2 lambs (p < 0.05), while no significant differences were recorded among eosinophil, mast cell and globule leucocyte counts in the abomasal mucosa (p > 0.05). The highest correlation coefficient recorded at the end of this study was between FEC and worm burden (r = 0.7). These two parameters showed a moderate negative correlation with PCV, plasma protein and mast cell counts in the abomasal mucosa. The results obtained in this study indicate that crossbreeding Florida Native and Rambouillet sheep can be a rapid way to combine and improve the characteristics of these two breeds. The parasitological results were promising, however, more studies will be necessary to verify the impact of crossbreeding in other traits. PMID- 9950338 TI - The determination at housing of exposure to gastrointestinal nematode infections in first-grazing season calves. AB - Various parameter estimates were assessed at housing in calves that had been exposed to gastrointestinal nematodes during a first grazing season. The analysis involved 41 groups of first grazing season (FGS) calves on 15 different farms in Belgium and comprised groups that had received chemoprophylactic treatment and untreated controls. Serum pepsinogen levels gave the clearest division between chemoprophylactic-treated calf groups (all were <2.6 U tyr), and untreated calf groups in which sub-clinical (range: 2.0-4.1 U tyr) and clinical infections (range 3.7-6.3 U tyr) occurred. There was also a tight relationship between individual pepsinogen values and adult Ostertagia burdens obtained at slaughter. In chemoprophylactic-treated groups there was a significant negative relationship between mean serum pepsinogen levels at housing and the proportion of the grazing season covered by different chemoprophylactic systems. Although only limited data on crude adult Ostertagia antigen ELISA were available, a good relationship between optical densities and estimated exposure was also found. The parasitological parameters, faecal egg counts and pasture Ostertagia larval counts at housing, and weight gain per day, gave less clear divisions among the three categories (chemoprophylaxis, sub-clinical and clinical). Distinguishing how much exposure a calf group has experienced during a first grazing season could help in designing more appropriate control measures for the FGS calves in the next year, assuring good protection and at the same time allowing sufficient exposure for the development of acquired immunity to Ostertagia, and for this serum pepsinogen is recommended. PMID- 9950339 TI - Prevalence of encysted apicomplexans in muscles of raptors. AB - An acid-pepsin digestion technique was used to examine portions of breast muscle and heart from raptors for encysted protozoans. Apicomplexan zoites were present in 52 (45.6%) of the 114 samples examined: 11 of 12 (91.7%) red-shouldered hawks (Buteo lineatus), 20 of 34 (58.8%) red-tailed hawks (Buteo jamaicensis), two of seven (28.6%) Cooper's hawks (Accipiter cooperi), three of four (75%) sharp shinned hawks (Accipiter striatus), one (100%) Mississippi kites (Ictinia misisippiensis), one of two (50%) American kestrels (Falco sparverius), one bald eagle (Haliaeetus leucocephalus), one of two (50%) golden eagles (Aquila chrysaetos), one of three (33%) turkey vultures (Cathartes aura), two of three (66.7%) black vultures (Coragyps atratus), three of six (50%) great-horned owls (Bubo virginianus), five of 15 (33.3%) barred owls (Strix varia), and one of 12 (8.3%) screech owls (Asio otus). Encysted protozoans were not observed in digests of tissues from three broad-winged hawks (Buteo platypterus), four ospreys (Pandion haliaetus), and five barn owls (Tyto alba). Apicomplexan cysts resembling Sarcocystis species were observed in tissue sections of muscles from 28 (37.8%) of 74 raptors. PMID- 9950340 TI - Comparative evaluation of two emigration/sedimentation techniques for the recovery of dictyocaulid and protostrongylid larvae from faeces. AB - A comparison between the performance of a flask and a funnel method in recovering dictyocaulid and protostrongylid larvae from faeces revealed the clear superiority of the former. On an average, 137% (p<0.01) more Dictyocaulus viviparus, 175% (p<0.05) more Muellerius capillaris and 1709% (p < 0.01) more Elaphostrongylus cervi larvae were recovered from samples processed by flask rather than funnel. Attempts to further improve the flask method by substituting cloth stockinette for paper tissue, tended to result in the recovery of more faecal debris but no more larvae. In addition to its greater sensitivity, it is suggested that the flask method offers advantages over the funnel system both in terms of time-saving and in lessening the likelihood of cross-contamination. PMID- 9950341 TI - Recovery of Oxyuris equi eggs from hemomelasma ilei lesions on ileal serosa of a Thoroughbred yearling filly. PMID- 9950343 TI - Regional seroprevalence of Cryptosporidium parvum-specific IgG of cats in the United States. AB - The objective of this study was to determine the regional prevalence of Cryptosporidium parvum-specific IgG in the sera of cats in the United States. The continental United States was partitioned into eight regional areas. Serum samples from 75 cats from each region were assayed for C. parvum-specific IgG using an indirect enzyme-linked immunosorbent assay (ELISA). Age, sex, breed, and indoor/outdoor status were examined as possible risk factors for developing a positive C. parvum-specific IgG antibody titer. The presence of gastro-intestinal signs and Toxoplasma gondii-specific IgG in the serum were also evaluated for association with C. parvum seropositivity. Of the 600 samples assayed, 50 (8.3%) were positive for C. parvum-specific IgG. Regional seroprevalence ranged from 1.3% in the mid-Atlantic states to 14.7% in the south-eastern states. The oldest group of cats (>10 years) had the highest seroprevalence (15.3%). The prevalence of C. parvum-specific IgG was higher among male (10.1%) than among female cats (6.9%), although, the difference was not statistically significant (p = 0.17). Seropositivity was not associated with pure-bred status. C. parvum-specific IgG antibodies was detected most frequently in T. gondii-specific IgG seropositive cats, outdoor cats, and cats with gastro-intestinal signs. These results suggest that cats in the United States are commonly exposed to C. parvum. PMID- 9950342 TI - Cryptosporidium and concurrent infections with other major enterophatogens in 1 to 30-day-old diarrheic dairy calves in central Spain. AB - Faeces samples from 218, 1 to 30-day-old, diarrheic dairy calves in 65 dairy herds were screened for the presence of Cryptosporidium and concurrent infections with rotavirus, coronavirus, F5 Escherichia coli and Salmonella spp. Calves were grouped according to their age as follows: 1-7, 8-14, 15-21 and 22-30 days. Cryptosporidium infection was detected in 43.8%, 71.9%, 63.2% and 6.9% of the calves in the respective age groups. Significant differences in the detection rate of Cryptosporidium were found between the age group 22-30 days and all other age groups, and between the age group 1-7 days and the age groups 8-14 days and 15-21 days. Cryptosporidium was the only enteropathogen detected in 60 of the 114 (52.6%) diarrheic calves. Concurrent infections with other enteropathogen(s) were detected in 64.3%, 46.3%, 39.5% and 0% of the Cryptosporidium-infected calves in the age groups 1-7, 8-14, 15-21 and 22-30 days, respectively. A significant age associated decrease in the detection rate of mixed infections (p < 0.05) was found. The detection rates of the other enteropathogens considered in calves with Cryptosporidium infection were 87% for rotavirus, 11.1% for coronavirus, 27.8% for F5+ E. coli and 1.8% for Salmonella. PMID- 9950344 TI - Study on the sequential tsetse-transmitted Trypanosoma congolense, T. brucei brucei and T. vivax infections to African buffalo, eland, waterbuck, N'Dama and Boran cattle. AB - Susceptibility of African buffalo, eland, waterbuck, N'Dama and Boran cattle to sequential Glossina morsitans centralis-transmitted infections of Trypanosoma congolense, T. brucei brucei and T. vivax was compared, and their possible role as reservoirs of these parasites for G. moristans centralis, G. pallidipes, G. austeni, G. brevipalpis and G. longipennis determined. The buffalo, eland, waterbuck and N'Dama controlled T. congolense parasitaemias and were able to prevent anaemia. By contrast, one Boran became severely anaemic whilst the other controlled parasitaemia and anaemia. When the above five species of Bovidae were rechallenged with T. brucei brucei they showed persistent parasitaemias but did not develop anaemia. The buffalo died of other causes. When the remaining four bovids were rechallenged with T. vivax they became infected with mixed T. vivax/T. b. brucei parasites. Eland, waterbuck and N'Dama controlled parasitaemias and anaemia whereas the Boran became anaemic. Cyclical development of T. congolense occurred in G. moristans centralis when fed on the bovid hosts, with buffalo being infective for tsetse flies for a much longer period. There was no relationship between the levels of T. congolense parasitaemia in the bovid hosts and the resultant infection rates in tsetse flies. Glossina m. centralis was more susceptible than G. pallidipes to T. brucei brucei whilst G. austeni the least; G. brevipalpis and G. longipennis were refractory to the mature infection. Again there was no relationship between T. brucei brucei parasitaemia levels in the hosts and infection rates in the flies. Glossina m. centralis and G. pallidipes showed mixed T. brucei brucei/T. vivax infections whilst G. austeni, G. brevipalpis and G. longipennis became infected with T. vivax alone. Tsetse flies showed higher T. vivax infection rates when fed on the hosts with high parasitaemias than thosewith low parasitaemias. Thus trypanotolerant African buffalo, eland, waterbuck, N'Dama as well as some trypanosusceptible Boran cattle can serve as reservoirs of single or mixed trypanosome infections for tsetse flies. This study has also shown that the Ag-ELISA on the sera from the five bovid hosts had low sensitivity and species-specificity. Examinations of thin wet blood films and buffy coats with a phase-contrast microscope were not sensitive enough to detect the parasites on all occasions. Xenodiagnosis using mice for T. brucei brucei and T. congolense infections, and tsetse flies for all the three trypanosome species were most sensitive for the detection of trypanosome infections in the bovid hosts. PMID- 9950345 TI - Effects of Trypanosoma congolense infection and diet on puberty, age at first lambing and haematology changes in Djallonke ewe lambs. AB - The interactions between T. congolense infection and nutritional supplements on onset of puberty and age at first lambing were observed in 24 young Djallonke ewes. As experimental design, a randomised complete block design was used with four treatment combinations, of which two were kept on a restricted diet (L), the remainder on an unrestricted diet (H) and half of each nutritional group being infected with T. congolense (LI and HI), the remainder serving as controls (LC and HC). Infection with T. congolense took place at an average age of 6 months and 15 days. Mortality due to trypanosome infection was zero and clinical symptoms were not obvious. Intensity of parasitaemia and packed cell volume (PCV) drop following trypanosome infection were similar in both infected groups (HI and LI). High dietary supplementation resulted temporarily in a better haematopoietic response following trypanosome infection, measured as a macrocytic anaemia. Dry matter intake (DMI) was significantly depressed in the HI group immediately following infection. Trypanosome infection had a negative effect on live weight gain during the chronic phase, with the difference being most obvious in the HI group (interaction diet x infection; p< or =0.05). Whereas trypanosome infection had no significant effect, high supplementary feeding significantly reduced the age at first cycling. Age at first lambing was similarly reduced by the diet. Trypanosome infection tended (p< or =0.09) to delay age at first lambing with a mean difference of 31.5+/-22.4 days between infected and controls. Interactions between diet and infection for age at first cycling/lambing were not significant, indicating these effects were just additive. Neither birth weights nor growth rates of offspring born to the experimental animals were significantly affected by previous trypanosome infection, nor by the diet of the dam. In contrast, lamb mortality up to 3 months of age was significantly increased by infection of the dam and most losses arose in group LI. In conclusion, the effects of trypanosome infection on puberty and age at first lambing were indirectly mediated through depression of growth rates. Nutritional supplementation enabled a better erythropoietic response to T. congolense infection and better offspring survival rates but resulted in more depressed weight gains. The results however clearly indicated the delaying effect of insufficient feeding on onset of puberty and reproductive performance in young Djallonke sheep. PMID- 9950346 TI - PCR diagnosis of benzimidazole-susceptibility or -resistance in natural populations of the small ruminant parasite, Teladorsagia circumcincta. AB - We have developed a new molecular tool for the diagnosis of the benzimidazole (BZ)-susceptibility or resistance in Teladorsagia circumcincta a nematode parasite of small ruminants. This tool is based on the use of the PCR and allows the genotyping of resistant (rr) or susceptible (rS and SS) adult worms or larvae. By using four primers in the same reaction mixture, worms can be genotyped in regard to the mutation on the residue 200 (phenylalanine to tyrosine) of the beta-tubulin which is implicated in BZ resistance. A very high proportion of homozygous SS (Phe/Phe) individuals characterized the BZ susceptible populations, whereas a variable proportion of homozygous rr (Tyr/Tyr) individuals characterized the BZ resistant populations. A positive correlation was observed between the LD50 estimated by egg hatch assay, and the proportion of mutant homozygous individuals rr (Tyr/Tyr). Our PCR method allows the rapid genotyping of numerous worms and permits the detection of the first resistant individuals in a worm population. PMID- 9950347 TI - Comparison of six in vitro tests in determining benzimidazole and levamisole resistance in Haemonchus contortus and Ostertagia circumcincta of sheep. AB - Six in vitro methods for the detection of anthelmintic resistance were compared using benzimidazole/levamisole-resistant Haemonchus contortus and benzimidazole/levamisole/ivermectin-resistant Ostertagia circumcincta as well as susceptible strains of both parasite species. The degree of resistance to thiabendazole and levamisole was compared by (1) an egg hatch assay, (2) an egg hatch paralysis assay, (3) a larval development assay, (4) a larval paralysis assay (5) a larval paralysis assay with physostigmine and (6) larval micromotility assay. The degree of resistance for each assay was expressed as resistance factor--RF. For the detection of thiabendazole and levamisole resistance, the larval development test was observed as the most sensitive to measure quantitatively a degree of resistance between susceptible and resistant strains. For this test the RF for thiabendazole and levamisole was 14.3 and >32.5, respectively in H. contortus strains and 21.1 and 3.5 in strains of O. circumcincta. Egg hatch assay was also found to be sensitive and accurate in determining of resistance to benzimidazole. For measurement of levamisole resistance the egg hatch paralysis assay and larval paralysis assay were found to be able to distinguish between strains, but some disadvantages of these techniques make it unsuitable for field detection of levamisole resistance. Other in vitro assays as larval paralysis assay with physostigmine and larval micromotility assay were also investigated. Significant differences in paralysis of the larvae were observed using larval paralysis assay. PMID- 9950348 TI - Enhancement of resistance in mice treated with Lactobacillus casei: effect on Trichinella spiralis infection. AB - The ability of viable Lactobacillus casei, administered by an intraperitoneal route, to induce resistance in mice against Trichinella spiralis infection was tested. The percent reduction of adult worms in the intestine 5 days after T. spiralis infection observed in L. casei-treated animals, compared with those of the control group, fluctuated between 70.9 and 88.5%; reductions of larvae per gram of muscle tissue, evaluated at 30 days after infection, varied from 46.6 to 84.4% in L. casei-treated mice compared with controls. At 5 days after infection, intestinal villus height was shorter in T. spiralis-infected animals than in L. casei-treated or uninfected mice. There were fewer mast cells/crypt unit in L. casei-treated and uninfected mice than in T. spiralis-infected animals. Lactobacilli-treated mice showed twice as many mononuclear cells/crypt unit as T. spiralis-infected animals. The IFN-gamma serum level was higher in L. casei treated animals at the time of worm challenge as compared with T. spiralis infected or uninfected mice. The results indicate that: (1) L. casei increased resistance that acted against T. spiralis infection in mice, (2) this resistance apparently was directed against adult worms in the intestine. PMID- 9950349 TI - The effect of continuous drug exposure on the immune response to Trichostrongylus colubriformis in sheep. AB - The effect of albendazole (ABZ)-capsule (CRC) administration on parasite establishment and immunity to ABZ-resistant (RES) and -susceptible (SUS) T. colubriformis was measured in Romney lambs. During 12 weeks of twice-weekly dosing with 3000 parasite larvae (L3), eggs were observed in faeces from CRC treated and untreated lambs given RES L3, but not CRC-treated lambs given SUS L3. Following the period of trickle challenge all lambs were drenched and, 1 week later, dosed with 20000 SUS L3. Resulting worm burdens were higher in control lambs than in those previously treated with CRCs and challenged with SUS, which in turn were higher than those in the CRC-treated or -untreated lambs previously challenged with RES L3. During the period of trickle challenge, the number of peripheral eosinophils and titres of anti-L3 and anti-adult antibody were raised only in those groups given RES L3. There was no effect of CRC administration. Following drench and challenge, antibody titres and eosinophil numbers increased in the control animals but not in those groups which had received previous trickle infection. The results demonstrate that the larval challenge alone resulted in incomplete though substantial protection against subsequent parasite challenge. The use of CRCs may potentially impact on subsequent animal performance and selection for anthelmintic resistance through a reduced level of immunity. PMID- 9950350 TI - Quantitation of equine cytokine mRNA expression by reverse transcription competitive polymerase chain reaction. AB - A reverse transcription-competitive polymerase chain reaction (RT-cPCR) method was developed to quantitate equine interleukin (IL)-1alpha, IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12 p35, IL-12 p40, interferon-gamma (INF-gamma), tumor necrosis factor-alpha (TNF-alpha), and beta-actin mRNA expression. Using primers based on equine-specific sequences, these cytokines could be detected in concanavalin A-stimulated peripheral blood mononuclear cells. The specificity of the amplified product was confirmed by sequencing. For each cytokine, the assay was made quantitative by generating competitor DNA fragments (mimic) containing the same primer template as a equine cytokine, but differing in size to make them distinguishable on an agarose gel. Serial dilutions of the mimic were added to PCR reactions containing constant amount of equine cDNA. Following gel electrophoresis and ethidium bromide staining, densitometric analysis of the bands corresponding to the target and mimic were used to construct a standard curve from which the amount of target cDNA was derived. Quantitation of IL-6 gene expression from a cDNA sample on four different days gave a coefficient of variation or 6.6%. Sample-to-sample variation in the efficiency of the reverse transcription as well as in the quantity of quality of starting RNA was considerably attenuated by normalizing the results to beta-actin mRNA expression used as a house-keeping gene. Small differences (2-fold) in cytokine mRNA expression were reliably detected. The sensitivity and reproducibility of this technique will make it valuable in following changes in equine cytokine gene expression in vitro and in vivo. In addition, the RT-cPCR technique described will have broad applicability for quantitation of cytokine gene expression in other animal species of veterinary interest. PMID- 9950351 TI - Equine herpesvirus type 1 infects dendritic cells in vitro: stimulation of T lymphocyte proliferation and cytotoxicity by infected dendritic cells. AB - Equine herpesvirus type 1 (EHV-1) causes respiratory disease, abortion and myeloencephalopathy in horses. As with other herpesviruses, cell-mediated immunity is considered important for both recovery and protection. Although virus specific T-cell proliferation and cytotoxicity can be detected following in vivo infection, little is known about the role of antigen presenting cells such as dendritic cells (DCs) in these processes. Peripheral blood DCs were shown to express the viral glycoprotein gB perinuclearly following exposure to EHV-1 in vitro, demonstrating EHV-1 replication within them. Co-culture of infected DCs or their supernatants with a susceptible cell line (RK13) demonstrated that EHV-1 infection was productive. In vitro-infected DCs showed cytopathic effects, including loss of viability and syncytial formation. However, they were superior to other antigen presenting cells in stimulating both peripheral blood T-cell proliferation and cytotoxicity. Although ponies which had been intranasally infected with EHV-1 exhibited T-cell proliferation to live virus presented on DCs, the responses began to decline as early as 15 weeks and cease at 22 weeks post-in vivo infection. Cytotoxic responses were not detected 35 weeks after the first intranasal infection but were seen again 7 weeks following a second infection. These findings show that equine DCs, which are infected with EHV-1 in vitro, can stimulate memory T-cell responses but appear unable to circumvent the short-lived memory response found following this infection in vivo. PMID- 9950352 TI - Dual-color flow cytometric analysis of phenotype, activation marker expression, and proliferation of mitogen-stimulated bovine lymphocyte subsets. AB - Bovine peripheral blood mononuclear cells were cultured in vitro for 3 days with the mitogens concanavalin A (Con A), pokeweed mitogen (PWM), phytohemagglutinin (PHA), and anti-CD3 monoclonal antibody. Activation of T-lymphocyte subsets (CD4+, CD8+, and gammadelta T-cell receptor+) and of B-cells was measured by two color flow cytometric analysis of subset expression of IL-2 receptor alpha (CD25) and MHC class II. Proliferation of lymphocyte subsets was directly measured by two-color flow cytometric analysis of fluorescence intensity of PKH2, a fluorescent dye that stably incorporates into cell membranes. CD4+ and CD8+ T cell subsets were stimulated by all the mitogens to increase expression of IL2r and MHC II and to proliferate. Deltagamma+ T-cells responded to all four mitogens with increased IL2r and MHC II expression. Con A and PHA caused measurable proliferation of deltagamma+ T-cells, but PWM and anti-CD3 did not. B-cells generally responded to the mitogens with increased IL2r and MHC II expression. B cells proliferated when incubated with Con A, but did not measurably proliferate in response to PWM, PHA, or anti-CD3. PMID- 9950354 TI - Effect of peroral anti-bacterial antiserum treatment on intestinal immune parameters of germ-free piglets intragastrically infected with virulent Salmonella typhimurium or enteropathogenic E. coli. AB - Germ-free piglets were orally infected with either enteropathogenic E. coli 055 or a virulent strain of Salmonella typhimurium. Orally applied antiserum against E. coli protected infected animals in spite of the fact that the bacteria were consistently found in mesenteric lymph nodes and other organs. By contrast, the application of an antiserum against S. typhimurium was without any effect on the outcome of infection. The treatment with anti-bacterial antiserum prevented inflammation of ileal mucosa (TNF-alpha and heat shock protein 65 expression) only in piglets infected with E. coli. A decrease in the frequency of ileal MAC320+ cells was observed in all infected piglets treated with antiserum. PMID- 9950353 TI - Pregnancy-associated glycoprotein and decreased polymorphonuclear leukocyte function in early post-partum dairy cows. AB - Phagocytosis and oxidative burst activity of polymorphonuclear neutrophil leukocytes (PMN) isolated from blood and pregnancy-associated glycoprotein (bPAG) concentrations in plasma were evaluated in two longitudinal studies in dairy cows from 3 weeks before until 5 weeks after calving, carried out in the United States and in Europe. Ingestion of Staphylococcus aureus by blood PMN increased during the first week after calving and normalised 3 weeks post-partum. Phagocytosis of Escherichia coli did not change in the early post-partum period. In both studies, a significant decrease in oxidative burst activity of PMN was observed between 1 and 3 weeks after calving. In all cows, a very significant increase in plasma bPAG concentration was found between 1 week before and 2 weeks after calving. The peak of bPAG concentration in plasma immediately preceded the alterations of blood PMN functions. These results suggest that bPAG may be associated with inhibition of PMN function of dairy cows during the early post-partum period. PMID- 9950355 TI - In vitro exposure with beta-hydroxy-beta-methylbutyrate enhances chicken macrophage growth and function. AB - Beta-hydroxy-beta-methylbutyrate (HMB), a leucine catabolite, has been shown to decrease broiler mortality. One possible target of HMB action may be the cells of the immune system. Macrophages from a chicken macrophage cell line, MQ-NCSU, were exposed to 0, 10, 20, 40, 80, and 100 microg of HMB per 5 x l0(4) cells in a 96 well culture plate. After 24 h of exposure, macrophage proliferation was quantitated by an MTT bioassay. In duplicate experiments, HMB stimulated growth over control (p < or = 0.05) at a wide range of doses. Macrophages were exposed to 20 and 80 microg of HMB and the culture supernatant fractions tested for the presence of nitrite. HMB exposure (20 microg) increased nitrite production by 44.1% over the controls (Experiment 1, p< or =0.035). To determine the phagocytic potential of macrophages after HMB exposure, MQ-NCSU cell line and Sephadex-G50 elicited abdominal macrophages were incubated with fluorescent latex beads (1:40, macrophage to beads ratio) for I h and then analyzed by flow cytometry. When exposed to 40 microg HMB, the phagocytic potential of MQ-NCSU macrophages was significantly higher (31.7%) than that of the controls (p < or = 0.0006). Sephadex-elicited macrophages exhibited 14.4% increased phagocytosis over controls when treated with 80 microg HMB (p < or = 0.0016). When MQ-NCSU macrophages were exposed to HMB, Fc-receptor expression was significantly elevated over the controls (p < or = 0.0001). These data demonstrate that HMB exposure induces proliferation of macrophages in culture as well as enhances macrophage effector functions, such as nitrite production and phagocytosis. The findings of these studies imply that HMB can be used as a possible dietary immunomodulator. PMID- 9950356 TI - Optimum conditions for in vitro chicken IL-2 production and its in vivo role in Newcastle disease vaccinated chickens. AB - Optimum conditions for in vitro chicken interleukin-2 (IL-2) production were studied. IL-2 containing culture supernatants were generated by mitogen stimulation of splenic mononuclear cells (SMC) and the samples were tested on 72 h Concanavalin A (ConA) blasts for their proliferative ability. 3H-thymidine incorporation was used as a measurement of proliferation. Higher stimulation indices and thus maximal IL-2 production were obtained with the following culture conditions: 5 x 10(6) cells ml(-1) cultured for 24 h in the presence of 10 microg ml(-1) ConA in serum free Iscove's modified Dulbecco medium. The molecule responsible for IL-2 activity was found to have a molecular weight of 14000 as estimated by size exclusion chromatography. SMC obtained from chickens inoculated with Newcastle disease virus were used to study the immunomodulatory role of IL 2. The lymphocyte transformation test was used as an in vitro correlate of cell mediated immunity in these chickens. The mitogen responses of cells obtained from virus inoculated and control chickens were similar on the basis of stimulation indices. Antigen specific lymphocyte proliferation was demonstrated using SMC obtained from virus inoculated chickens. Uptake of exogenous IL-2 by 72 h ConA blasts was of similar magnitude in both virus inoculated and control chickens indicating that uptake of IL-2 by T lymphocytes was normal in Newcastle disease virus inoculated chickens. PMID- 9950357 TI - Parasite infection and Japanese cedar pollinosis in monkeys. AB - To evaluate the relationship between helminthic parasite infection and sensitization to Japanese cedar (Cryptomeria japonica; CJ) pollen allergens in Japanese monkeys (Macaca fuscata), we examined the parasite infection, presence of anti-pollen allergen IgE and development of pollinosis. Serum samples and fecal specimens were taken from 169 monkeys in five troops, and the presence of IgE antibody for CJ pollen allergen and of helminthic parasite eggs in their feces was examined. Of the 169 monkeys, helminthic parasite eggs from 138 monkeys were detected. The frequency of anti-CJ IgE (19%) and the level of total IgE did not differ significantly between the monkeys with and without parasite eggs. We examined the presence of anti-CJ IgE and pollinosis symptoms in 31 monkeys of a troop; six of the monkeys demonstrated anti-CJ IgE and pollinosis symptoms. Five of these six monkeys had parasite eggs. We found that the monkeys that demonstrated anti-CJ IgE and pollinosis symptoms had helminthic parasite infections. These data suggest that helminthic parasite infection does not reduce the development of clinical signs of CJ pollinosis in Japanese monkeys. PMID- 9950359 TI - Sex related expressivity of the phenotype in coronal craniosynostosis caused by the recurrent P250R FGFR3 mutation. AB - A recurrent point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene that converts proline 250 into arginine is commonly associated with coronal craniosynostosis and has allowed definition of a new syndrome on a molecular basis. Sixty-two patients with sporadic or familial forms of coronal craniosynostosis were investigated for the P250R FGFR3 mutation. It was identified in 20 probands originating from 27 unrelated families (74%), while only 6/35 sporadic cases (17%) harboured the mutation. In both familial and sporadic cases, females were significantly more severely affected than males. Hence, while 68% of females carrying the P250R mutation showed brachycephaly, only 35% of males had the same phenotype. In the most severe forms of the disease, the association of bicoronal craniosynostosis with hypertelorism and marked bulging of the temporal fossae were common hallmarks that might be helpful for clinical diagnosis. Taken together, these results indicate that the P250R FGFR3 mutation is mostly familial and is associated with a more severe phenotype in females than in males. The sex related severity of the condition points to the possible implication of modifier genes in this syndrome. PMID- 9950360 TI - Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition. AB - BACKGROUND/AIMS: The development of colorectal cancer and a variable range of extracolonic manifestations in familial adenomatous polyposis (FAP) is the result of the dominant inheritance of adenomatous polyposis coli (APC) gene mutations. In this study, direct mutation analysis of the APC gene was performed to determine genotype-phenotype correlations for nine extracolonic manifestations and to investigate the incidence of APC mutations in non-FAP colorectal cancer. METHODS: The APC gene was analysed in 190 unrelated FAP and 15 non-FAP colorectal cancer patients using denaturing gradient gel electrophoresis, the protein truncation test, and direct sequencing. RESULTS: Chain terminating signals were only identified in patients belonging to the FAP group (105 patients). Amino acid changes were identified in four patients, three of whom belonged to the non-FAP group of colorectal cancer patients. Genotype-phenotype correlations identified significant differences in the nature of certain extracolonic manifestations in FAP patients belonging to three mutation subgroups. CONCLUSIONS: Extended genotype-phenotype correlations made in this study may have the potential to determine the most appropriate surveillance and prophylactic treatment regimens for those patients with mutations associated with life threatening conditions. This study also provided evidence for the pathological nature of amino acid changes in APC associated with both FAP and non-FAP colorectal cancer patients. PMID- 9950358 TI - Spinal muscular atrophy: untangling the knot? AB - Spinal muscular atrophy (SMA), a clinically and genetically heterogeneous group of neuromuscular diseases, is a disorder of motor neurones characterised by degeneration of spinal cord anterior horn cells and muscular atrophy. SMA is an autosomal recessive disorder with a carrier frequency of about 1150. Three candidate genes, the survival motor neurone (SMN) gene, the neuronal inhibitory protein (NAIP) gene, and the p44 (subunit of basal transcription factor TFIIH) gene, have been considered as genes involved in this condition. The region spanning these genes has a complex organisation including duplications, repetitive sequences, truncated genes, and pseudogenes, which makes molecular analysis of this condition difficult. Although deletions have been found in the majority of SMA patients, a few microrearrangements (like duplications, missense mutations, microdeletions, and gene conversions) localised in the telomeric form of the SMN gene have also been reported. The function of the protein encoded by the SMN gene is still not fully understood but recent studies have indicated that it is found intracellularly in gems, novel nuclear structures. Its interaction with other proteins suggests a role in mRNA processing and metabolism. Whether the NAIP gene protein and other apoptosis associated proteins are directly involved in the initial stages of neurone degeneration and apoptosis, or acting downstream on the pathological pathway, has been difficult to determine. Further studies will be required to elucidate possible functional interactions between these proteins. PMID- 9950361 TI - Molecular basis of iduronate-2-sulphatase gene mutations in patients with mucopolysaccharidosis type II (Hunter syndrome). AB - Mucopolysaccharidosis type II (Hunter syndrome) is an X linked lysosomal storage disorder resulting from heterogeneous mutations in the iduronate-2-sulphatase (IDS) gene. To detect IDS gene mutations, direct sequencing of IDS cDNA fragments coupled with assays on IDS genomic amplicons was applied to 18 unrelated patients with MPS II. Seventeen mutations were detected from the 18 patients including seven missense mutations (S71R, A82E, A85T, R88C, R468W, R468Q, and E521V), five deletions (alphaR95, 383delAT, 596delAACA, 1148delC, and 1216delCT), two insertions (208insC and 1063insA), two splicing mutations (1006+5g-->c in intron 7, 1122C-->T in exon 8), and an intragenic deletion of IDS exons 4, 5, 6, and 7. Nine of the small mutations were novel mutations. Mutation 596del-AACA was detected in two unrelated patients. The mutation in intron 7 was found to cause aberrant splicing and resulted in a 22 bp insertion into its mRNA transcript. The intragenic deleted IDS gene expressed two aberrant mRNA transcripts consisting of exons 1-2-8-9 and 3-8-9. Analysis of mutations A85T, R88C, R468Q, R468W, and 438C/T found no polymorphism for the four missense mutations but about 36% heterozygosity for the 438C/T silent mutation. These results provide further evidence of mutational heterogeneity for MPS II. Also, underlying sequence directed mutagenesis mechanisms for some recurrent mutations in the IDS gene were proposed. PMID- 9950362 TI - Mucopolysaccharidosis type IIIB (Sanfilippo B): identification of 18 novel alpha N-acetylglucosaminidase gene mutations. AB - Mucopolysaccharidosis type IIIB (MPS IIIB or Sanfilippo B disease) is an autosomal recessive storage disorder caused by deficiency of the lysosomal enzyme a-N-acetylglucosaminidase. Mutation screening was performed on a group of 22 patients using a combination of SSCP/heteroduplex analysis of amplified genomic fragments and direct sequencing of cDNA fragments. Twenty-one different mutations were identified, 18 of them novel. Together they account for 82% of the disease alleles. The mutation spectrum consists of two small insertions, two small deletions, three nonsense mutations, and 14 different missense mutations, one of them (M1L) affecting the initiation codon. The vast genetic heterogeneity seen in this disorder is reflected by the fact that only three of the mutations were identified in more than one patient. PMID- 9950363 TI - Clinical and genetic studies on 12 preaxial polydactyly families and refinement of the localisation of the gene responsible to a 1.9 cM region on chromosome 7q36. AB - Polydactyly is the most frequently observed congenital hand malformation with a prevalence between 5 and 19 per 10000 live births. It can occur as an isolated disorder, in association with other hand/foot malformations, or as a part of a syndrome, and is usually inherited as an autosomal dominant trait. According to its anatomical location, polydactyly can be generally subdivided into pre- and postaxial forms. Recently, a gene responsible for preaxial polydactyly types II and III, as well as complex polysyndactyly, has been localised to chromosome 7q36. In order to facilitate the search for the underlying genetic defect, we ascertained 12 additional families of different ethnic origin affected with preaxial polydactyly. Eleven of the kindreds investigated could be linked to chromosome 7q36, enabling us to refine the critical region for the preaxial polydactyly gene to a region of 1.9 cM. Our findings also indicate that radial and tibial dysplasia/aplasia can be associated with preaxial polydactyly on chromosome 7q36. Combining our results with other studies suggests that all non syndromic preaxial polydactylies associated with triphalangism of the thumb are caused by a single genetic locus, but that there is genetic heterogeneity for preaxial polydactyly associated with duplications of biphalangeal thumbs. Comparison of the phenotypic and genetic findings of different forms of preaxial polydactyly is an important step in analysing and understanding the aetiology and pathogenesis of these limb malformations. PMID- 9950364 TI - Cystic fibrosis carrier frequencies in populations of African origin. AB - Cystic fibrosis (CF) is a common autosomal recessive disorder in populations of European descent. However, very little is known about CF in populations of African origin among whom it has been believed to be extremely rare. The aim of this study was to determine if this is the case or whether it is under-reported. A CFTR mutation, 3120+1G-->A, which was first reported in three African-American CF patients, has been shown to account for 9-14% of African-American CF chromosomes. It has also been found in 4/6 CF chromosomes in South African blacks and one CF chromosome of Cameroonian origin. In order to determine the carrier frequency of the 3120+1G-->A mutation in Africa, 1360 unrelated, healthy subjects were screened. Nine carriers were identified. In addition, two out of five black CF patients with positive sweat tests were found to be heterozygous for the 3120+1G-->A mutation and two out of another four black patients with symptoms suggestive of CF, but unconfirmed by sweat tests, were heterozygous for the D1270N mutation. A further three CFTR mutations, A559T, S1255X, and 444delA, which had been found in African-American CF patients, were not identified in the patients or in over 373 healthy subjects tested. The 3120+1G-->A mutation has a carrier frequency of 1 in 91 (8/728) in South African blacks with a 95% confidence interval of 1 in 46 to 1 in 197. Since this mutation accounts for between 15% and 65% of CF chromosomes in South African blacks, a corrected CF carrier frequency would be between 1 in 14 and 1 in 59. Hence, the incidence of CF would be predicted to be between 1 in 784 and 1 in 13924 births in this population. There are several possible reasons why these people are not being detected. Some of these are misdiagnosis as chronic pulmonary infection, malnutrition, tuberculosis, infantile diarrhoea, failure to thrive, or a high infant mortality rate. PMID- 9950366 TI - Sotos syndrome and cutis laxa. AB - Characteristics suggestive of connective tissue dysfunction have been described in Sotos syndrome and include joint hyperextensibility, pes planus, and a high arched palate. A variety of cutis laxa syndromes have also been described, some of them exhibiting mental retardation, but no reports have drawn an association with overgrowth or abnormal facies characteristic of Sotos syndrome. We report three patients with the anthropometric and dysmorphological appearance of classical Sotos syndrome in association with redundant skin folds, joint hypermobility, and, in two of the three, vesicoureteric reflux suggestive of a coexisting connective tissue disorder. All of the patients had a normal bone age suggesting that Sotos syndrome in its classically described form was not present and that this entity possibly reflects a related, perhaps allelic, condition. PMID- 9950365 TI - Preimplantation genetic diagnosis for couples at high risk of Down syndrome pregnancy owing to parental translocation or mosaicism. AB - The population risk for trisomy 21 is 1 in 700 births but some couples are at a much higher risk owing to parental translocation or mosaicism. We report on the first attempt to carry out preimplantation genetic diagnosis for two such couples using cleavage stage embryo biopsy and dual colour FISH analysis. Each couple underwent two treatment cycles. Couple 1 (suspected gonadal mosaicism for trisomy 21) had two embryos normal for chromosome 21 transferred, but no pregnancy resulted; 64% (7/11) unfertilised oocytes/embryos showed chromosome 21 aneuploidy. Couple 2 (46,XX,t(6;21)(q13;q22.3)) had a single embryo transferred resulting in a biochemical pregnancy; 91% (10/11) oocytes/embryos showed chromosome 21 imbalance, most resulting from 3:1 segregation of this translocation at gametogenesis. The opportunity to test embryos before implantation enables the outcome of female meiosis to be studied for the first time and the recurrence risk for a Down syndrome pregnancy to be assessed. PMID- 9950367 TI - A small interstitial deletion in the GPC3 gene causes Simpson-Golabi-Behmel syndrome in a Dutch-Canadian family. AB - Deletions in the heparan sulphate proteoglycan encoding glypican 3 (GPC3) gene have recently been documented in several Simpson-Golabi-Behmel syndrome (SGBS) families. However, no precisely defined SGBS mutation has been published. We report here a 13 base pair deletion which causes a frameshift and premature termination of the GPC3 gene in the Dutch-Canadian SGBS family in whom the trait was originally mapped. Our analysis shows that a discrete GPC3 disabling mutation is sufficient to cause SGBS. Furthermore, our finding of a GPC3 normal daughter of an SGBS carrier with skeletal abnormalities and Wilms tumour raises the possibility of a trans effect from the maternal carrier in SGBS kindreds. PMID- 9950368 TI - Myotonic dystrophy: the correlation of (CTG) repeat length in leucocytes with age at onset is significant only for patients with small expansions. AB - Myotonic dystrophy (DM) was the first of a group of diseases to be identified for which the genetic basis is the expansion of a triplet repeat. Myotonic dystrophy also exhibits anticipation, in which the disease worsens through successive generations. These two features have led many groups to analyse whether a significant negative correlation between triplet repeat length and severity of disease exists. However, the recent molecular finding that two distinct subsets of classically affected DM patients exist, those who export expansion derived DMPK RNA and those who do not, led us to question whether combining data from these two sets of patients is statistically valid. We found that although patients with small expansions showed a significant correlation between age at onset and triplet repeat length, those with larger expansions did not. The theoretical triplet repeat size, which separated the two groups, was also deduced. PMID- 9950369 TI - Unstable expansion of the CAG trinucleotide repeat in MAB21L1: report of a second pedigree and effect on protein expression. AB - MAB21L1, originally termed CAGR1, is the human homologue of the C. elegans cell fate determining gene mab21. MAB21L1, mapped to 13q13, contains a highly polymorphic 5' untranslated CAG repeat that normally ranges from six to 31 triplets in length. A pedigree has been previously reported in which the repeat length is expanded to 45-50 triplets and is transmitted unstably between generations; the expansion did not correlate to a clinical phenotype but did exhibit somatic mosaicism. We now report a second pedigree with an expanded and unstably transmitted MAB21L1 CAG repeat of similar length. The expansion is not clearly associated with a clinical phenotype, though the complexity of the pedigree renders any conclusion concerning phenotype-genotype relationships speculative. The expansion did not result in decreased expression of MAB21L1 protein. The length, C-G rich composition, somatic mosaicism, and unstable transmission of the expanded CAG repeat in MAB21L1 resemble the premutations observed in other genes, such as FMR1 and MDPK, in which longer expanded repeats are associated with a clinical phenotype. This raises the possibility that longer expansions in the MAB21L1 repeat may also be associated with a clinical phenotype. PMID- 9950370 TI - Familial adenomatous polyposis associated with multiple adrenal adenomas in a patient with a rare 3' APC mutation. AB - Familial adenomatous polyposis (FAP) is characterised by hundreds of colorectal adenomas. Endocrine neoplasms have occasionally been reported, as have gastric polyps, which are usually hamartomatous in the fundus of the stomach and adenomatous in the antrum. A 57 year old man with colorectal, gastric, and periampullary adenomatous polyposis, in association with three bilateral adrenocortical adenomas, is presented. Mutation screening showed a 5960delA germline mutation in the adenomatous polyposis coli (APC) gene predicted to lead to a premature stop codon. This mutation was found in three of the four children of the patient. Western blot analysis of a lymphoblastoid cell line derived from the patient failed to detect any truncated APC polypeptide. This rare 3' mutation is responsible for an unusually complex and late onset phenotype of FAP. PMID- 9950371 TI - High prevalence of the C634Y mutation in the RET proto-oncogene in MEN 2A families in Spain. AB - The RET proto-oncogene encodes a receptor tyrosine kinase expressed in neural crest derived tissues. Germline mutations in the RET proto-oncogene are responsible for three different dominantly inherited cancer syndromes: multiple endocrine neoplasia type 2A (MEN 2A), type 2B (MEN 2B), and familial medullary thyroid carcinoma (FMTC). MTC can also occur sporadically. Molecular characterisation of the RET proto-oncogene has been performed by PCR-SSCP analysis, direct DNA sequencing, and restriction enzyme analysis in 49 unrelated, Spanish, MEN 2 families: 30 MEN 2A families, six FMTC families, and 13 families classified as "other". Germline missense mutations in one of six cysteine codons (609, 611, 618, and 620 in exon 10, and codons 630 and 634 in exon 11), which encode part of the extracellular cysteine rich domain of RET, have been detected in the majority of these families: 100% of MEN 2A families, 67% of FMTC families, and 54% of families classified as "other". No RET mutations in exons 10, 11, 13, 14, 15, or 16 were detected in the remaining families. The most frequent RET mutation in MEN 2A Spanish families is C634Y, occurring in 73% of cases. Haplotype analysis does not exclude the possibility of founder effects in Spanish MEN 2A families with the C634Y mutation. PMID- 9950372 TI - De novo 10q22 interstitial deletion. AB - We describe a 4 month old male with a de novo interstitial deletion of chromosome 10q22. His clinical features included growth deficiency, developmental delay, ocular hypertelorism, posteriorly rotated ears, retrognathia, and fifth finger clinodactyly. He later developed dental lamina cysts of the alveolar ridge. To our knowledge, this is the first reported case of an interstitial deletion of 10q22. PMID- 9950373 TI - Duplication of segment 1p21 following paternal insertional translocation, ins(6;1)(q25;p13.3p22.1). AB - A moderately mentally retarded 3 year old boy showed minor anomalies including a prominent forehead and flat occiput, exophthalmos, large and prominent ears, high arched palate, umbilical hernia, sacral dimple, and irregular position of the toes. Cardiac sonography disclosed a chorda running through the left ventricle. Cytogenetic investigation of the family showed a balanced insertional translocation of segment 1p13-->p22 into distal 6q in the father which had led, through unbalanced segregation, to duplication of 1p13.3-->p22.1 in the proband. Familial duplication of such a small interstitial segment of 1p has not been reported previously, and the paucity of abnormal physical findings in the proband compared to previous patients with a similar aberration is remarkable. PMID- 9950374 TI - Molecular and cytogenetic characterisation of an unusual case of partial trisomy/partial monosomy 13 mosaicism: 46,XX,r(13)(p11q14)/46,XX,der(13)t(13;13)(q10;q14). AB - A female infant with multiple malformations and mental retardation was noted to have a rare de novo chromosome abnormality involving mosaicism with two cell lines, one with a ring chromosome 13, and the other with partial trisomy 13 owing to a complex rearrangement. Cytogenetic examination excluded the presence of a t(13q;13q) cell line and showed a cell line with a marker chromosome containing two chromosome 13 long arms joined together after deletion of a part (q11-->q14) of one of them. In addition, the absence of a cell line with two normal chromosomes 13 or a cell line with a t(13q;13q) implies that the ring (13) and the marker (13) arose from a single event at the first cleavage division. The two cell lines were present in different proportions in both peripheral blood lymphocytes and skin fibroblasts. The results of microsatellite characterisation clearly indicate the paternal origin and the absence of recombination, supporting the postzygotic origin of both the ring and the marker chromosome. PMID- 9950375 TI - Anomalous right pulmonary artery origins in association with the fetal valproate syndrome. AB - Two cases are reported of fetal valproate syndrome in association with anomalous right pulmonary artery origin. Both diagnoses were confirmed following cardiac catheterisation as echocardiography alone was inadequate to define the anatomy. Anomalous right pulmonary artery origin is extremely rare making a chance association with fetal valproate syndrome very unlikely. We recommend that anomalous pulmonary artery origin is borne in mind in patients with valproate syndrome undergoing cardiac assessment, particularly as this may be a difficult diagnosis to make on echocardiography. PMID- 9950376 TI - Frequency of mutations for glycogen storage disease type II in different populations: the delta525T and deltaexon 18 mutations are not generally "common" in white populations. PMID- 9950377 TI - Infant methionine synthase variants and risk for spina bifida. PMID- 9950378 TI - Intravenous saline has no effect on blood ethanol clearance. AB - For patients presenting to emergency departments with ethanol intoxication, intravenous (i.v.) fluids are initiated for varied reasons. This investigation determined the effect of i.v. fluid therapy on the rate of blood ethanol clearance in such patients. Volunteers received a predetermined dose of ethanol on two separate occasions. On the second occasion, volunteers rapidly received a liter of i.v. saline directly following ethanol ingestion. At intervals on both occasions, blood ethanol levels were estimated using a breath analyzer. Using linear regression analysis, no difference was found in rates of alcohol clearance with or without i.v. fluid intervention. The common rate of clearance between both groups was 15 mg/dL/h (95% CI 12 to 18). We conclude that i.v. fluid therapy does not accelerate ethanol clearance in intoxicated patients. While such therapy may be justified for other reasons, practitioners are cautioned against initiating fluids in such patients solely to expedite ethanol elimination. PMID- 9950379 TI - Residency-trained emergency physicians: their demographics, practice evolution, and attrition from emergency medicine. AB - Concern exists about the ability of Emergency Physicians (EPs) to maintain a career in Emergency Medicine (EM) over a professional lifetime. The objectives of this study were to assess the practice characteristics of residency trained EPs, to document how the EP's responsibilities evolve throughout a career, and to assess career longevity. A retrospective cohort study using a mailed questionnaire was used to document practice characteristics, evolution of responsibility, and career longevity from all physicians who graduated from allopathic EM residencies between 1978-1988 (inclusive). Non-responders were compared to responders to assess the extent of selection bias. The response rate was 58.1% (1635/2812). There were no differences between responders and non responders on any of five demographic variables. Responders who were more likely to remain in EM included those who had higher reimbursement, were board certified in EM, or did not train in another specialty or do a fellowship outside of EM. Throughout the 15-year careers studied, EPs noted a significant shift in the time spent doing clinical work (decreased) and the time doing administrative work (increase). The attrition from EM practice for this cohort was < 1% per year. PMID- 9950380 TI - Cricothyrotomy technique: standard versus the Rapid Four-Step Technique. AB - Standard cricothyrotomy technique uses a tracheal hook cephalad to the opening to stabilize the trachea during endotracheal (ET) tube passage. A newly described Rapid Four-Step Technique (RFST) uses the tracheal hook caudal to the opening to stabilize the trachea during ET tube passage. This experimental crossover trial compared standard cephalad tracheal hook traction to caudad traction as recommended by RFST in a cadaver model of cricothyrotomy. Outcome measures included the incidence of complications and the size of ET tube able to be passed with each technique. The anterior necks of 30 formalin-fixed cadavers were dissected to completely reveal the cricothyroid membranes and surrounding structures. Two emergency medicine residents performed all cricothyrotomies. Each cadaver was randomly assigned to undergo either standard open technique followed by RFST, or RFST followed by standard open technique. Standard open technique was performed using a #11 scalpel blade, a Trousseau dilator for widening the opening, and a tracheal hook held cephalad through the thyroid cartilage. RFST was performed using a #11 scalpel blade and a tracheal hook held caudad through the cricoid cartilage. Cuffed ET tubes without stylettes were passed in progressively larger sizes until significant resistance was met as determined independently by two physicians. The size of the largest ET tube passed for each technique was recorded. After each attempt the trachea was inspected for evidence of structural damage and the balloon cuff was checked to assess for cuff rupture. There were no complications with standard technique; five cadavers (16.7%) had complications with RFST including one (3.3 %) with balloon cuff rupture and four (13.3 %) with cricoid cartilage fractures. Tracheal damage prevented standard technique performance on three of the cadavers. There was no significant difference between maximal ET tube sizes for standard technique (median size 7.0, mean 6.95 mm internal diameter) versus RFST (median size 7.0, mean 6.82 mm internal diameter). We conclude that RFST may be associated with a higher incidence of complications than standard technique as demonstrated by our cadaver model of cricothyrotomy. We were unable to demonstrate a difference between the two techniques with regards to size of ET tube able to be passed. PMID- 9950381 TI - Retrospective denial of emergency department payments is inappropriate. AB - Third-party payers typically use patients' discharge diagnoses to determine "appropriate" Emergency Department (ED) usage. This analysis compared the resource intensity involved in ED evaluation for "inappropriate" and all other ED visits. In this retrospective database review, 11 discharge diagnoses (DX11) (chronic nasopharyngitis; chronic sinusitis; chronic pharyngitis; rhinitis; constipation; head cold; hemorrhoids; toothache; flu; headache; and tension headache) were identified by a third party payor as being "inappropriate" for ED evaluation. The chief complaints of all patients seen in 1994 and 1995 with one of the DX11 were identified along with their E & M billing level, ED length of stay (LOS), and the frequency of consultation. In this urban, university trauma center, 1994 and 1995 visits totaled 120,402. Eighty-two different chief complaints were associated with a final diagnosis of DX11; 79% of all ED patients presented with one of the chief complaints (AllCC). Four percent of patients with DX11 were admitted, and the AllCC group had comparable resource utilization to the entire ED population. Patients' presenting complaints are incapable of predicting diagnosis or disposition. Retrospective denial of payment by discharge diagnosis is inappropriate. PMID- 9950383 TI - Rectal "oven mitt": the importance of considering a serious underlying injury. AB - A 20-year-old man presented with a rectal "oven mitt," which was removed transanally. Rigid proctosigmoidoscopy revealed no apparent perforation, but subsequent contrast enema using meglumine diatrizoate demonstrated an extraperitoneal rectal perforation, which was probably caused by a wooden stick used to forcefully introduce the glove through the patient's anus. Thus, rectal injuries may be caused not by the foreign object itself, but by another object used as an introducer. PMID- 9950382 TI - Ehrlichiosis. AB - A case of human ehrlichiosis is presented. This case review emphasizes the need for a thorough history and physical examination in all patients who present with relatively non-specific complaints such as headaches, chills, myalgias, and arthralgias. These complaints should elicit the question of recent tick exposure from the clinician, particularly if the area is endemic for various rickettsial diseases. Laboratory findings such as leukopenia, thrombocytopenia, and increased hepatic enzymes should strongly suggest the disease. PMID- 9950384 TI - Inaccuracy in endotracheal tube verification using a Toomey syringe. AB - The Toomey syringe and other esophageal detection devices have been shown to be highly sensitive and specific for indicating whether an endotracheal (ET) tube is in the esophagus or the trachea. Many prehospital systems use the Toomey syringe method as the major determinant in deciding whether or not to remove an ET tube after an intubation attempt. We present three cases in which various pulmonary pathologies led to false positive results; that is, Toomey syringe aspiration indicated esophageal placement when the tube was correctly positioned in the trachea. A literature review follows the case reports. PMID- 9950385 TI - Vocal cord dysfunction mimicking a severe asthma attack. AB - Vocal cord dysfunction is a rare type of airway obstruction that may mimic an acute asthma attack. We present a case of a patient who arrived in the Emergency Department (ED) in acute respiratory distress, with a history of severe asthma requiring previous intubation, who was diagnosed with vocal cord dysfunction by bronchoscopy in the ED. PMID- 9950387 TI - Thyrotoxic periodic paralysis in a Jamaican male. AB - Thyrotoxic periodic paralysis is a rare endocrine disorder most prevalent among individuals of Asian descent that presents as proximal muscle weakness, hypokalemia, and signs of hyperthyroidism. We present the case report of a patient with previously undiagnosed hyperthyroidism, protracted muscle weakness with transient exacerbations, and nocturnal onset of periodic paralysis affecting the upper and lower limbs. PMID- 9950386 TI - Thyrotoxic periodic paralysis: a case report and review of the literature. AB - Hypokalemic periodic paralysis occurring in thyrotoxicosis is rare in Caucasians and is not often highlighted as an endocrine emergency. Periodic paralysis, without familial background, manifests only in the thyrotoxic patient. Thyrotoxic periodic paralysis is a self-limiting disorder that is cured by the treatment of the underlying hyperthyroidism. We report an unusual case of acute onset weakness from thyrotoxic periodic paralysis in a young Chinese migrant who had a normal serum potassium level at the time of initial presentation, though on subsequent presentation one week later, he had the typically associated hypokalemia. We also review the literature on thyrotoxic periodic paralysis. PMID- 9950388 TI - Hypnosis for pediatric fracture reduction. AB - Hypnosis can diminish pain and anxiety for many emergency patients during examinations and procedures. While hypnosis has been used for millennia and was demonstrated to be of use in clinical medicine more than a century ago, modern physicians have been reluctant to adopt this technique in clinical practice. This article describes four children with angulated forearm fractures who had no possible access to other forms of analgesia during reduction, and in whom hypnosis was used successfully. A simple method for hypnotic induction is described. PMID- 9950389 TI - Severe metabolic alkalosis due to baking soda ingestion: case reports of two patients with unsuspected antacid overdose. AB - Oral ingestion of baking soda (sodium bicarbonate) has been used for decades as a home remedy for acid indigestion. Excessive bicarbonate ingestion places patients at risk for a variety of metabolic derangements including metabolic alkalosis, hypokalemia, hypernatremia, and even hypoxia. The clinical presentation is highly variable but can include seizures, dysrhythmias, and cardiopulmonary arrest. We present two cases of severe metabolic alkalosis in patients with unsuspected antacid overdose. The presentation and pathophysiology of antacid-related metabolic alkalosis is reviewed. PMID- 9950390 TI - Soft tissue injection of hydrocarbons: a case report and review of the literature. AB - Hydrocarbon injection, while commonly seen in domestic accidents or attempted suicide, is not extensively addressed in the literature. This article comprises a review of the various complications of intravascular and soft tissue injection of petroleum distillates, and provides recommendations for patient management. An illustrative case involving the subcutaneous injection of dripless oil, a mixture of mineral oil, nonionic detergents, and petroleum naphtha, is presented. PMID- 9950391 TI - The medical impact of tornadoes in North America. AB - North America suffers some of the most severe tornado disasters of any location on the planet. Significant injury and economic impact may result from these storms, particularly in rural areas. Tornadic storms present unique problems for prehospital and Emergency Department personnel. Soft tissue injuries seen after tornadoes are contaminated with polymicrobial flora and may require delayed primary closure. Fractures are a frequent cause of hospital admission and head injury is a frequent cause of death. Advanced warning and proper sheltering actions by a population are the most significant factors in reducing morbidity and mortality. This article reviews the pertinent literature on the medical impact of tornadoes and details the mechanisms of injury, nature of injuries, pre hospital and ED planning points associated with tornadic storms. PMID- 9950393 TI - Benign pneumoperitoneum associated with pneumomediastinum and pneumoretroperitoneum in ambulatory outpatients. AB - Perforation of a hollow viscus and other dangerous etiologies must always be considered in the evaluation of free peritoneal air. Pneumoperitoneum in the presence of pneumoretroperitoneum and pneumomediastinum, however, often results from air tracking from a pathologic source outside of the abdomen along the mesentery into the peritoneum. This syndrome is relatively benign, and should be considered when there are multiple sites of extraluminal air in order to minimize the risk of unnecessary exploratory laparotomy. Two cases of benign pneumoperitoneum associated with pneumomediastinum and pneumoretroperitoneum are presented. PMID- 9950392 TI - Evaluation of CK-MB isoform analysis for early diagnosis of myocardial infarction. AB - Measurement of CK-MB and its isoforms by high-voltage electrophoresis has been proposed as a sensitive test for early detection of myocardial infarction (MI). We performed a prospective study of this test in 231 patients presenting to the Emergency Department with symptoms consistent with ischemic chest pain. Blood specimens were obtained at 0, 1, and 3 h following presentation, and plasma was immediately frozen and analyzed within 1 week by high-voltage electrophoresis for total CK-MB and isoforms. The test was considered positive whenever total CK-MB was elevated (>6 U/L) or the cardiac isoform MB2 was relatively increased (MB2 > 2 U/L and MB2/MB1 > 1.7). This test had a sensitivity of 68% overall and 55% for specimens collected within 3 h of symptom onset. It was positive within 3 h of presentation in 36/39 (92%) of patients with confirmed MI. Specificity was 92% overall and did not vary with time after symptoms. The CK-MB alone, at the cutoff of 6 U/L, had lower sensitivity overall (56%; p = 0.01) and within 3 h of onset (39%; p = 0.03), and higher specificity overall (98%; p < 0.001). Lowering the cutoff for CK-MB alone to match the sensitivity of the isoform test caused a greater loss of specificity. It is concluded that analysis of CK-MB by high voltage electrophoresis is an effective method for rapid diagnosis of MI, with the isoform analysis enhancing early sensitivity. PMID- 9950394 TI - Carbon monoxide poisoning: a review for clinicians. AB - Carbon monoxide (CO) poisoning continues to be a significant health problem both in the United States and in many other countries. CO poisoning is associated with a high incidence of severe morbidity and mortality. Epidemics of CO poisoning commonly occur during winter months and sources include: smoke from fires, fumes from heating systems burning fuels, and exhaust fumes from motor vehicles. The history of exposure and carboxyhemoglobin levels should alert the physician to this diagnosis. In the absence of exposure history, CO poisoning should be considered when two or more patients are simultaneously sick. The clinical presentation is non-specific and may range from nausea and headache to profound central nervous system dysfunction. The mainstay of therapy for CO poisoning is supplemental oxygen, ventilatory support, and monitoring for cardiac dysrhythmias. This article reviews up-to-date information of this potentially devastating exposure. PMID- 9950395 TI - Creatine kinase and its CK-MB isoenzyme: the conventional marker for the diagnosis of acute myocardial infarction. AB - Biochemical markers are commonly used for detection, diagnosis, and management of various diseases. Creatine kinase (CK) is an enzyme found in most tissues, and is the best known marker for the identification of acute myocardial infarction (AMI). We review the most common techniques used to quantify creatine kinase and its cardiac specific fraction, CK-MB. Electrophoresis, immunoinhibition, monoclonal immunoassay, and CK-MB isoform assays are considered for efficacy, sensitivity and specificity, and timeliness in the setting of acute non-traumatic chest pain. Limitations of the various techniques for identifying AMI are identified. Current recommendations for CK-MB panels, including combinations with other cardiac markers, are included. PMID- 9950396 TI - The differential diagnosis of shock. PMID- 9950397 TI - Nonaccidental trauma. PMID- 9950398 TI - Atlantoaxial dislocation. PMID- 9950399 TI - Emergency medicine as a martial art. PMID- 9950400 TI - Is thyrotoxic periodic paralysis a "channelopathy"? PMID- 9950401 TI - Piriform sinus perforation during esophageal-tracheal combitube placement. PMID- 9950402 TI - Evaluating applicants to emergency medicine residency programs. AB - This article reviews the pertinent literature related to the selection process of medical students to emergency medicine residency programs. The impact that academic performance in medical school, the interview, letters of recommendation, and other achievements have on the performance of the future resident are reviewed. All articles identified by an English language MEDLINE search were reviewed by the authors as to significance to the subject. Review of relevant literature indicates that no precise correlation can be made between performance in medical school and achievements during the residency, although there seems to be a correlation between academic performance in medical school and similar performance on board certification examinations. PMID- 9950403 TI - H is for headache. PMID- 9950404 TI - Canadian Association of Emergency Physicians Guidelines for the acute management of migraine headache. AB - The aim of this article is to provide an evidence-based guideline on the management of acute migraine headaches in the Emergency Department setting. After a Medline search that covered 1965 to the present, all randomized controlled trials were reviewed. Recommendations as to the efficacy of abortive anti migraine medications were based on the Canadian Medical Association's Guideline for Guidelines. Classes of medications that are discussed include: dopamine antagonists, serotonin agonists, opioids, local anesthetics, non-steroidal anti inflammatory agents, and steroids. The recommendations are limited to discussing the efficacy of specific medications, adverse effects to be expected, as well as associated headache rates after discharge. Specific recommendations as to which medication might offer a superior treatment have not been proposed due to lack of proper comparative trials as well as lack of information on headache and quality of life after discharge from the Emergency Department. PMID- 9950405 TI - Procedural sedation and analgesia in the emergency department. Canadian Consensus Guidelines. AB - Procedural sedation and analgesia are core skills in emergency medicine. Various specialty societies have developed guidelines for procedural sedation, each reflecting the perspective of the specialty group. Emergency practitioners are most likely to embrace guidelines developed by people who understand emergency department (ED) skills, procedures, conditions, and case mix. Recognizing this, the Canadian Association of Emergency Physicians (CAEP) determined the need to establish guidelines for procedural sedation in the ED. In March, 1996, a national emergency medicine (EM) working committee, representing adult and pediatric emergency physicians, was established. This committee teleconferenced with representatives of the Canadian Anesthetic Society (CAS) to identify problems, perspectives, and controversial issues, and to define a process for guideline development. The EM committee subsequently reviewed existing literature, determined levels of evidence, and developed the document, which evolved based on feedback from the CAS and CAEP Standards Committees. The final version was approved by the CAEP Standards Committee and the CAEP Board of Directors, then submitted for peer review. These guidelines discuss the goals, definitions, and principles of ED sedation, and make recommendations for pre sedation preparation, patient fasting, physician skills, equipment and monitoring requirements, and post-sedation care. The guidelines are aimed at non anesthesiologists practicing part-time or full-time emergency medicine. They are applicable to ED patients receiving parenteral analgesia or sedation for painful or anxiety-provoking procedures. They are intended to increase the safety of procedural sedation in the ED. PMID- 9950406 TI - The health transition fund and the future of Canadian health care delivery. PMID- 9950407 TI - International Emergency Medicine Reference List. PMID- 9950410 TI - Secondarily infected wounds and dermatoses: a diagnosis and treatment guide. AB - Secondary bacterial skin infections are common complications of primary dermatoses, primary nonbacterial skin infections, traumatic lesions, ulcers, cutaneous infestations, and other miscellaneous skin diseases. Most diagnoses are based on information obtained by patient history and physical examination. Secondary bacterial skin infections may be polymicrobial, commonly include the pathogens Staphylococcus aureus and Streptococcus pyogenes, and require proper antibiotic treatment. The use of topical antibiotics avoids the risk of systemic allergic reactions or generalized side effects, and provides a high antibiotic concentration at the site of infection. Therefore, topical antibiotics should be considered as potential primary therapy in the emergency department. When systemic therapy is indicated, most commonly used agents for secondary skin infections are the penicillinase-resistant semi-synthetic penicillins; the first generation cephalosporins, the macrolides; and combination antibacterials, such as amoxicillin/ clavulanate potassium and trimethoprim/sulfamethoxazole. PMID- 9950409 TI - Targeting lurking pathogens in acute traumatic and chronic wounds. AB - The appropriate antimicrobial treatment for skin and soft tissue following acute trauma is determined by the mechanism of injury, time from injury to treatment, environmental wound contamination, pathogenicity of colonizing bacteria, and patient-specific issues. These factors can be used to predict the risk of secondary infection of wounds. Although common skin pathogens (such as Staphylococcus aureus and group A Streptococcus) cause most secondary wound infections, antibiotic therapy sometimes must be directed against unusual pathogens that are associated with atypical wounds, such as animal bites (amoxicillin with clavulanate for Pasteurella multocida) and plantar puncture wounds (ciprofloxacin for Pseudomonas aeruginosa). This customized treatment approach is also appropriate for chronic wounds, such as pressure and diabetic foot ulcers. In addition to antibiotic therapy, wound management may include surgical debridement. Active areas of investigation in wound management include the use of growth factors and hyperbaric oxygen. PMID- 9950411 TI - Staphylococcus aureus isolation from the lesions, the hands, and anterior nares of patients with atopic dermatitis. AB - Staphylococcus aureus colonization is common in atopic dermatitis (AD) and can exacerbate the disease. Some patients with atopic dermatitis may act as a reservoir for S. aureus transmission to others. This study compared S. aureus colonization in atopic dermatitis patients and their caregivers with control patients and their caregivers. Quantitative cultures were obtained from the lesions, clinically normal skin, hands, and anterior nares of 100 patients with atopic dermatitis, 100 controls with other cutaneous disorders, and 200 caregivers. The AD patients had significantly greater presence of S. aureus from lesional and clinically normal skin, as well as the hand. Significantly increased carriage of S. aureus was found in the anterior nares of caretakers of AD patients compared with control caretakers. Topical corticosteroid use did not affect recovery of S. aureus. There was a significant correlation between recovery of S. aureus from lesional skin and recovery from the anterior nares and hands. The nares and hands may be important reservoirs and vectors for autotransmission of S. aureus to lesional skin and for transmission to patients with AD. PMID- 9950412 TI - Opportunities for mupirocin calcium cream in the emergency department. AB - Mupirocin calcium cream is a newly reformulated topical antibiotic with a bactericidal spectrum specific for the pathogens that frequently cause secondary infections in superficial wounds. Both the calcium cream and ointment formulations have demonstrated efficacy in the treatment of secondarily infected traumatic lesions and dermatoses, including eczema, burns, wounds, bites, and ulcers. Mupirocin has a low risk of systemic and topical complications. To date, antimicrobial resistance is rare among target pathogens. The use of mupirocin to treat secondary wound infection has a profile of high efficacy and does not impair the normal healing in traumatized skin. PMID- 9950413 TI - Towards the acceptance of embryo stem-cell therapies. PMID- 9950414 TI - Pig in the middle. PMID- 9950415 TI - Europe is urged to hold back on xenotransplant clinical trials. PMID- 9950416 TI - Sequence 'terrorist genes', says Venter. PMID- 9950418 TI - US life scientists seek 15 per cent rise to NIH research funds. PMID- 9950417 TI - Cancer body 'must do more for minorities'. PMID- 9950419 TI - UK gets the green light on modified crops. PMID- 9950420 TI - The odds of losing at genetic roulette. PMID- 9950421 TI - A new spin on handed asymmetry. PMID- 9950422 TI - Role of the giant panda's 'pseudo-thumb'. PMID- 9950423 TI - Yeast cell-type regulation of DNA repair. PMID- 9950425 TI - High genomic deleterious mutation rates in hominids. AB - It has been suggested that humans may suffer a high genomic deleterious mutation rate. Here we test this hypothesis by applying a variant of a molecular approach to estimate the deleterious mutation rate in hominids from the level of selective constraint in DNA sequences. Under conservative assumptions, we estimate that an average of 4.2 amino-acid-altering mutations per diploid per generation have occurred in the human lineage since humans separated from chimpanzees. Of these mutations, we estimate that at least 38% have been eliminated by natural selection, indicating that there have been more than 1.6 new deleterious mutations per diploid genome per generation. Thus, the deleterious mutation rate specific to protein-coding sequences alone is close to the upper limit tolerable by a species such as humans that has a low reproductive rate, indicating that the effects of deleterious mutations may have combined synergistically. Furthermore, the level of selective constraint in hominid protein-coding sequences is atypically low. A large number of slightly deleterious mutations may therefore have become fixed in hominid lineages. PMID- 9950424 TI - OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis. AB - The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation factor and regulator of interactions between T cells and dendritic cells in vitro. Mice with a disrupted opgl gene show severe osteopetrosis and a defect in tooth eruption, and completely lack osteoclasts as a result of an inability of osteoblasts to support osteoclastogenesis. Although dendritic cells appear normal, opgl-deficient mice exhibit defects in early differentiation of T and B lymphocytes. Surprisingly, opgl-deficient mice lack all lymph nodes but have normal splenic structure and Peyer's patches. Thus OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo. PMID- 9950427 TI - In vivo regulation of axon extension and pathfinding by growth-cone calcium transients. AB - Growth cones at the tips of extending neurites migrate through complex environments in the developing nervous system and guide axons to appropriate target regions using local cues. The intracellular calcium concentration ([Ca2+]i) of growth cones correlates with motility in vitro, but the physiological links between environmental cues and axon growth in vivo are unknown. Here we report that growth cones generate transient elevations of [Ca2+]i as they migrate within the embryonic spinal cord and that the rate of axon outgrowth is inversely proportional to the frequency of transients. Suppressing Ca2+ transients by photorelease of a Ca2+ chelator accelerates axon extension, whereas mimicking transients with photorelease of Ca2+ slows otherwise rapid axonal growth. The frequency of Ca2+ transients is cell-type specific and depends on the position of growth cones along their pathway. Furthermore, growth cone stalling and axon retraction, which are two important aspects of pathfinding, are associated with high frequencies of Ca2+ transients. Our results indicate that environmentally regulated growth-cone Ca2+ transients control axon growth in the developing spinal cord. PMID- 9950426 TI - Monocular deprivation induces homosynaptic long-term depression in visual cortex. AB - Brief monocular deprivation during early postnatal development can lead to a depression of synaptic transmission that renders visual cortical neurons unresponsive to subsequent visual stimulation through the deprived eye. The Bienenstock-Cooper-Munro (BCM) theory proposes that homosynaptic mechanisms of long-term depression (LTD) account for the deprivation effects. Homosynaptic depression, by definition, occurs only at active synapses. Thus, in contrast to the commonly held view that the synaptic depression caused by monocular deprivation is simply a result of retinal inactivity, this theoretical framework indicates that the synaptic depression may actually be driven by the residual activity in the visually deprived retina. Here we examine the validity of this idea by comparing the consequences of brief monocular deprivation by lid suture with those of monocular inactivation by intra-ocular treatment with tetrodotoxin. Lid suture leaves the retina spontaneously active, whereas tetrodotoxin eliminates all activity. In agreement with the BCM theory, our results show that monocular lid suture causes a significantly greater depression of deprived-eye responses in kitten visual cortex than does treatment with tetrodotoxin. These findings have important implications for mechanisms of experience-dependent plasticity in the neocortex. PMID- 9950428 TI - Secondary V(D)J recombination in B-1 cells. AB - B-1 B cells are a self-renewing population of B cells that differ from conventional B cells (B-2 cells) in that they are particularly predisposed to auto-antibody production. Although much is known about the signalling pathways that control B-1-cell growth and development, less is known about why these cells are prone to produce autoreactive antibodies. Here we show that B-1 cells, like germinal-centre B cells, can express recombinase-activating genes 1 and 2 (RAG1 and RAG2) and undergo secondary V(D)J recombination of immunoglobulin genes. In addition, B cells from autoimmune-prone NZB mice show high levels of RAG messenger RNA and recombination. We propose that secondary immunoglobulin-gene rearrangements outside organized lymphoid organs may contribute to the development of autoreactive antibodies. PMID- 9950429 TI - The 5-HT3B subunit is a major determinant of serotonin-receptor function. AB - The neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) mediates rapid excitatory responses through ligand-gated channels (5-HT3 receptors). Recombinant expression of the only identified receptor subunit (5-HT3A) yields functional 5 HT3 receptors. However, the conductance of these homomeric receptors (sub picosiemens) is too small to be resolved directly, and contrasts with a robust channel conductance displayed by neuronal 5-HT3 receptors (9-17 pS). Neuronal 5 HT3 receptors also display a permeability to calcium ions and a current-voltage relationship that differ from those of homomeric receptors. Here we describe a new class of 5-HT3-receptor subunit (5-HT3B). Transcripts of this subunit are co expressed with the 5-HT3A subunit in the amygdala, caudate and hippocampus. Heteromeric assemblies of 5-HT3A and 5-HT3B subunits display a large single channel conductance (16 pS), low permeability to calcium ions, and a current voltage relationship which resembles that of characterized neuronal 5-HT3 channels. The heteromeric receptors also display distinctive pharmacological properties. Surprisingly, the M2 region of the 5-HT3B subunit lacks any of the structural features that are known to promote the conductance of related receptors. In addition to providing a new target for therapeutic agents, the 5 HT3B subunit will be a valuable resource for defining the molecular mechanisms of ion-channel function. PMID- 9950430 TI - TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF kappaB1 p105. AB - The transcription factor NF-kappaB is composed of homodimeric and heterodimeric complexes of Rel/NF-kappaB-family polypeptides, which include Rel-A, c-Rel, Rel B, NF-kappaB/p50 and NF-kappaB2/p52 . The NF-kappaB1 gene encodes a larger precursor protein, p105, from which p50 is produced constitutively by proteasome mediated removal of the p105 carboxy terminus. The p105 precursor also acts as an NFkappaB-inhibitory protein, retaining associated p50, c-Rel and Rel-A proteins in the cytoplasm through its carboxy terminus. Following cell stimulation by agonists, p105 is proteolysed more rapidly and released Rel subunits translocate into the nucleus. Here we show that TPL-2 , which is homologous to MAP-kinase kinase kinases in its catalytic domain, forms a complex with the carboxy terminus of p105. TPL-2 was originally identified, in a carboxy-terminal-deleted form, as an oncoprotein in rats and is more than 90% identical to the human oncoprotein COT. Expression of TPL-2 results in phosphorylation and increased degradation of p105 while maintaining p50 production. This releases associated Rel subunits or p50-Rel heterodimers to generate active nuclear NF-kappaB. Furthermore, kinase inactive TPL-2 blocks the degradation of p105 induced by tumour-necrosis factor alpha. TPL-2 is therefore a component of a new signalling pathway that controls proteolysis of NF-kappaB1 p105. PMID- 9950431 TI - Health in Russia is broke, but who is to fix it? PMID- 9950432 TI - Treatments for severe pulmonary hypertension. PMID- 9950433 TI - Immunotherapy of non-metastatic complication of malignant disease. PMID- 9950434 TI - No cause for alarm over retinal side-effects of sildenafil. PMID- 9950435 TI - Integrins--the glue of life. PMID- 9950436 TI - What does postnatal care do for women's health? PMID- 9950437 TI - Choosing diseases for surveillance. PMID- 9950438 TI - Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial. AB - BACKGROUND: Colon cancer is curable by surgery, but cure rate depends on the extent of disease. We investigated whether adjuvant active specific immunotherapy (ASI) with an autologous tumour cell-BCG vaccine with surgical resection was more beneficial than resection alone in stage II and III colon cancer. METHODS: In a prospective randomised trial, 254 patients with colon cancer were randomly assigned postoperative ASI or no adjuvant treatment. ASI was three weekly vaccinations starting 4 weeks after surgery, with a booster vaccination at 6 months with 10(7) irradiated autologous tumour cells. The first vaccinations contained 10(7) BCG organisms. We followed up patients for time to recurrence, and recurrence-free and overall survival. Analysis was by intention to treat. FINDINGS: The 5.3 year median follow-up (range 8 months to 8 years 11 months) showed 44% (95% CI 7-66) risk reduction for recurrence in the recurrence-free period in all patients receiving ASI (p=0.023). Overall, there were 40 recurrences in the control group and 25 in the ASI group. Analysis by stage showed no significant benefit of ASI in stage III disease. The major impact of ASI was seen in patients with stage II disease, with a significantly longer recurrence-free period (p=0.011) and 61% (18-81) risk reduction for recurrences. Recurrence-free survival was significantly longer with ASI (42% risk reduction for recurrence or death [0-68], p=0.032) and there was a trend towards improved overall survival. INTERPRETATION: ASI gave significant clinical benefit in surgically resected patients with stage II colon cancer. ASI has minimal adverse reactions and should be considered in the management of stage II colon cancer. PMID- 9950439 TI - Association of two silent polymorphisms of platelet glycoprotein Ia/IIa receptor with risk of myocardial infarction: a case-control study. AB - BACKGROUND: The platelet membrane glycoprotein Ia/IIa plays a major part in platelet function as a primary receptor for collagen. A previous report showed a variation of glycoprotein Ia/IIa receptor density and function associated with two silent and linked polymorphisms (807C/T and 873G/A) within the glycoprotein Ia gene. Because platelet thrombus formation is implicated in the pathogenesis of acute myocardial infarction, we investigated these polymorphisms among patients who had had a myocardial infarction. METHODS: We did a 2/1 case-control study including 177 patients (median age 57.0 [range 32-72] years) and 89 controls with same age and sex. Distributions of the 807C/T and 873G/A polymorphisms were investigated by genotyping DNA by PCR, single-strand conformation polymorphism analysis, and sequencing. FINDINGS: The prevalence of the homozygous 807T/873A genotype was 2.9 times higher among patients with myocardial infarction than among controls (16.4% vs 5.6%, p=0.022). There was an association between patients homozygous for the 807T/873A allele and myocardial infarction (odds ratio 3.3 [95% CI 1.2-8.8]), which was strongest in a subgroup of smokers. The homozygous 807T/873A genotype remained an independent risk factor for myocardial infarction (p=0.005) when age, sex, smoking, hypertension, diabetes, body-mass index, LDL-cholesterol and HDL-cholesterol, and fibrinogen were adjusted for by logistic regression. INTERPRETATION: The 807T/873A homozygosity of the platelet glycoprotein Ia/IIa gene polymorphism, associated with differences in surface collagen receptor density and activity, appears to be an independent risk factor for acute myocardial infarction. Our findings need to be confirmed in a larger, prospective study that includes patients from different populations and cardiovascular risk groups. PMID- 9950440 TI - Risk of diphtheria among schoolchildren in the Russian Federation in relation to time since last vaccination. AB - BACKGROUND: Between 1990 and 1996, more than 110,000 cases and 2900 deaths from diphtheria were reported in the Russian Federation. In 1994, because disease rates were high among children aged 7-10 years, the age of administration of the second booster dose of diphtheria vaccine was lowered from 9 years to 6 years, the age of school entry. To assess the impact of this policy change, we did a matched case-control study in three Russian cities. METHODS: Children aged 6-8 years who had diphtheria between September, 1994, and December, 1996, were each matched with five to seven children acting as controls who were within 3 months of age of the case and were from the same class at school. We did a matched analysis using conditional logistic regression. FINDINGS: We analysed the immunisation records of 58 cases and 306 controls. All but one case and all controls had received at least three doses of diphtheria-toxoid vaccine. 19 (33%) cases and 144 (47%) controls had received a booster dose of diphtheria toxoid within the previous 2 years. Cases were more likely than were controls to have received only four doses rather than five (odds ratio 2.8 [95% CI 1.2-6.5]) and to have a time since the last dose of diphtheria toxoid of 3-4 years (3.1 [1.1 9.1]) or 5-7 years (15.0 [2.5-89.0]), compared with children for whom it was 2 years or less. On multivariate analysis only a time since the last dose of 5-7 years remained significantly associated with disease (matched odds ratio adjusted for total number of doses 10.9 [1.6-75.1]). CONCLUSION: A booster dose of diphtheria-toxoid vaccine given to children in the Russian Federation at 6-8 years of age reduced the interval since the last dose of diphtheria toxoid and improved protection against diphtheria. PMID- 9950441 TI - Feasibility and efficacy of routine PCR screening of blood donations for hepatitis C virus, hepatitis B virus, and HIV-1 in a blood-bank setting. AB - BACKGROUND: Despite sensitive antibody-based blood-donor screening, a residual risk of transfusion-transmitted viral infections exists. Only direct monitoring by sensitive nucleic-acid tests would provide data accurately to measure the risk and to assess risk-reduction procedures. We investigated the feasibility and efficacy of routine screening of donors for hepatitis C virus (HCV), hepatitis B virus (HBV), and HIV-1 by PCR. METHODS: For PCR testing, individual donor plasma samples were pooled (96x100 microL) overnight by two automatic pipetting machines. Viruses were concentrated by centrifugation and nucleic acids were extracted. HCV PCR was done on the Cobas Amplicor system (Hoffmann-La Roche, Mannheim, Germany). HBV and HIV-1 sequences were amplified by single (non-nested) in-house PCRs and detected by agarose-gel electrophoresis. Detection limits were 1000-5000 genome equivalents/mL in the donor blood. FINDINGS: PCR testing was done in parallel to antibody screening with a maximum throughput of 3000 samples in 7-8 h. Positive samples were identified 1-2 days later. 111 of 373,423 donations (107 of 4500 pools) were PCR and antibody/antigen-confirmed positive. We found one HCV PCR-positive antibody-negative donation with normal alanine aminotransferase and one HCV PCR-positive donation with an elevated alanine aminotransferase (100 IU), which was negative in the AxSYM 2.0 and Matrix 1.0, but positive after control in the Abbott Prism test (Abbott GmbH, Wiesbaden, Germany). INTERPRETATION: PCR is a suitable and fast blood-donor screening procedure and contributes to a reduction in viral transmission by transfusion of blood components. In our selected donor population, the yield of detected contaminated donations from donors in the time window in which they are highly infectious but do not have any symptoms or detectable antigen and antibody concentrations (diagnostic window), confirms theoretical estimates. PMID- 9950442 TI - Differences between asthma exacerbations and poor asthma control. AB - BACKGROUND: Increased variation in peak expiratory flow (PEF) is characteristic of poorly controlled asthma, and measurement of diurnal variability of PEF has been recommended for assessment of asthma severity, including during exacerbations. We aimed to test whether asthma exacerbations had the same PEF characteristics as poor asthma control. METHODS: Electronic PEF records from 43 patients with initially poorly controlled asthma were examined for all exacerbations that occurred after PEF reached a plateau with inhaled corticosteroid treatment. Diurnal variability of PEF was compared during exacerbations, run-in (poor asthma control), and the period of stable asthma before each exacerbation. FINDINGS: Diurnal variability was 21.3% during poor asthma control and improved to 5.3% (stable asthma) with inhaled corticosteroid treatment. 40 exacerbations occurred in 26 patients over 2-16 months; 38 (95%) of exacerbations were associated with symptoms of clinical respiratory infection. During exacerbations, consecutive PEF values fell linearly over several days then improved linearly. However, diurnal variability during exacerbations (7.7%) was not significantly higher than during stable asthma (5.4%, p=0.1). PEF data were consistent with impaired response to inhaled beta2-agonist during exacerbations but not during poorly controlled asthma. INTERPRETATION: Asthmatics remain vulnerable to exacerbations during clinical respiratory infections, even after asthma is brought under control. Calculation of diurnal variability may fail to detect important changes in lung function. PEF variation is strikingly different during exacerbations compared with poor asthma control, suggesting differences in beta2-adrenoceptor function between these conditions. PMID- 9950443 TI - Control of hypercalcaemia of parathyroid carcinoma by immunisation. AB - BACKGROUND: Patients with parathyroid tumours can develop extreme hypercalcaemia and osteitis fibrosa cystica. Clinical features result from the action of parathyroid hormone (PTH) on bone receptors. Because this hormone is produced in microgram quantities, inhibition of its metabolic effects with potent PTH antibodies should be possible. We tested whether an immunisation with synthetic human and bovine PTH peptides could stimulate autoantibodies against PTH. METHODS: A patient with metastatic parathyroid carcinoma in the lungs and pleura developed severe bone disease and extreme hypercalcaemia that proved resistant to conventional therapy. She was immunised with 200 microg human and bovine PTH peptides and 50 microg human PTH. Booster doses were also given at 4 weeks and 11 weeks. The patient was then seen every week. FINDINGS: Antibodies against PTH were produced within 4 weeks of initial immunisation and titres increased with repeated doses of immunogens. Total serum calcium concentrations, which had ranged from 3.5 mmol/L to 4.2 mmol/L over the previous 18 months, fell to between 2.5 mmol/L and 3.0 mmol/L over 6 months of therapy. This fall was accompanied by striking clinical improvement. INTERPRETATION: We believe this is the first use of immunotherapy to control remote, non-metastatic complications of malignant disease. B-cell tolerance to human PTH was broken by immunisation with PTH peptides in adjuvant. This therapeutic approach could be used to control excess hormone production in several types of endocrine tumour and may have applications in other diseases. PMID- 9950444 TI - Hypercalcaemia in sarcoidosis. PMID- 9950445 TI - Retinal side-effects of sildenafil. PMID- 9950447 TI - Prevalence of admission hyperglycaemia across clinical subtypes of acute stroke. PMID- 9950446 TI - Is management of impotence with sildenafil changing clinical practice? PMID- 9950448 TI - Pre-pregnancy microalbuminuria predicts pre-eclampsia in insulin-dependent diabetes mellitus. Copenhagen Pre-eclampsia in Diabetic Pregnancy Study Group. PMID- 9950449 TI - Headache after frequent use of serotonin agonists zolmitriptan and naratriptan. PMID- 9950451 TI - Computer-assisted cardiac surgery. PMID- 9950450 TI - Smoking in adults and passive smoking in children are associated with acute appendicitis. PMID- 9950452 TI - Interobserver variability in the use of APACHE II scores. PMID- 9950453 TI - Emergence of adult diarrhoea rotavirus in Calcutta, India. PMID- 9950454 TI - Mortality in the CHAOS trial. PMID- 9950455 TI - Non-Mediterranean periodic fever. PMID- 9950456 TI - Hypnosis makes headway in the clinic. PMID- 9950457 TI - More patches for the healthcare system. PMID- 9950458 TI - Euro will challenge finances of healthcare systems in Europe. PMID- 9950459 TI - Indian welfare minister orders compulsory HIV testing for children in care. PMID- 9950460 TI - Colorectal cancer. AB - Colorectal cancer is a leading cause of morbidity and mortality with about 300,000 new cases and 200,000 deaths in Europe and the USA each year. Published trials have established a role for chemotherapy in colorectal cancer, in the adjuvant setting for Dukes C colon cancer, with an absolute survival benefit of about 5% and in advanced colorectal cancer, for which it improves quality of life and increases survival by 6-12 months. For rectal cancer, radiotherapy decreases rates of local recurrence and, in locally advanced disease, successfully palliates pain, tenesmus, and bleeding. The evolving understanding of colorectal carcinogenesis, in particular recognition of vital genes that may be mutated or lost during tumour development, has been translated into innovative gene therapy techniques. Finally it is increasingly apparent that surgical site specialisation and a multidisciplinary approach (including surgeons, pathologists, and oncologists) may lead to optimum outcomes for patients with colorectal cancer. PMID- 9950461 TI - Placebo-controlled studies in rheumatoid arthritis: ethical issues. PMID- 9950462 TI - The genesis line. PMID- 9950463 TI - Fetal surgery for spina bifida. PMID- 9950464 TI - Fetal surgery for spina bifida. PMID- 9950465 TI - Fetal surgery for spina bifida. PMID- 9950466 TI - UK small aneurysms trial. PMID- 9950467 TI - UK small aneurysms trial. PMID- 9950468 TI - UK small aneurysms trial. PMID- 9950469 TI - Too little, too late, too sloppy: delivery care in Africa. PMID- 9950470 TI - Socioeconomic status and stage at presentation of colorectal cancer. PMID- 9950471 TI - Management of germ cell tumours of the testis. PMID- 9950472 TI - Oral or parenteral therapy for vitamin B12 deficiency. PMID- 9950473 TI - Oral or parenteral therapy for vitamin B12 deficiency. PMID- 9950474 TI - Oral or parenteral therapy for vitamin B12 deficiency. PMID- 9950475 TI - Development of clinical guidelines. PMID- 9950476 TI - HIV/AIDS information overload. PMID- 9950477 TI - In-flight assistance. PMID- 9950478 TI - In-flight assistance. PMID- 9950479 TI - Misleading government information on NHS costs. PMID- 9950480 TI - Nicaraguan health care. PMID- 9950481 TI - Too short or too fat: should we be monitoring weight? PMID- 9950482 TI - Vaccination against HBV in France. PMID- 9950483 TI - Meet my uncle. PMID- 9950484 TI - Getting on with AIDS. PMID- 9950485 TI - The Nobel chronicles. 1936: Henry Hallett Dale (1875-1968) and Otto Loewi (1873 1961). PMID- 9950486 TI - Sketches from The Lancet. Venereal diseases. PMID- 9950487 TI - Surgical decompression for traumatic brain swelling: indications and results. AB - OBJECT: Decompressive craniectomy has been performed since 1977 in patients with traumatic brain injury. The authors assess the efficacy of this treatment and the indications for its use. METHODS: The clinical status of the 57 patients, their computerized tomography (CT) scans, and intracranial pressure (ICP) levels were documented prospectively in a standard protocol. At the beginning of the study, all patients older than 30 years were excluded. As of 1989 patients older than 40 years were excluded until 1991; since that time patients older than 50 years have been excluded. Primary brain or brainstem injury with fully developed bulbar brain syndrome, loss of auditory evoked potentials (AEPs), and/or oscillation flow in a transcranial Doppler ultrasound examination were contraindications to decompressive craniectomy. A positive indication for decompression was given in the case of progressive therapy-resistant intracranial hypertension in correlation with clinical (Glasgow Coma Scale [GCS] score, decerebrate posturing, dilating of pupils) and electrophysiological (electroencephalography, somatosensory evoked potentials, and AEPs) parameters and with findings on CT scans. Unilateral decompressive craniectomy was performed in 31 patients and bilateral craniectomy in 26 patients. In all cases, a wide frontotemporoparietal craniectomy was followed by a dura enlargement covered with temporal muscle fascia. The outcomes of the treatment were surprisingly good. Only 11 patients (19%) died, three of whom died of acute respiratory disease syndrome. Five patients (9%) survived, but remained in a persistent vegetative state; six patients (11%) survived with a severe permanent neurological deficit, and 33 patients (58%) attained social rehabilitation. Two patients (3.5%) did not have a follow-up examination. The GCS score on the 1st day posttrauma and the mean ICP turned out to be the best predictors for a good prognosis. The results demonstrate the importance of decompressive craniectomy in the treatment of traumatic brain swelling. CONCLUSIONS: Surgical decompression should be routinely performed when indicated before irreversible ischemic brain damage occurs. PMID- 9950489 TI - The efficacy of an abbreviated course of nimodipine in patients with good-grade aneurysmal subarachnoid hemorrhage. AB - OBJECT: Nimodipine therapy has become a standard component of the treatment regimen used in patients with aneurysmal subarachnoid hemorrhage (SAH). Its prescribed use at 60 mg every 4 hours for 21 days is based on reputable, randomized prospective studies. However, because only 20 to 30% of patients with SAH suffer clinical cerebral vasospasm, it is clear that most patients do not actually need the drug. Of course, this fact is not evident until several treatment days have passed. It is common practice, without well-documented consequences, to terminate nimodipine therapy before 21 days in certain clinical circumstances. The aim of this study was to evaluate the effectiveness of abbreviating the duration of nimodipine treatment in the setting of a good-grade aneurysmal SAH. METHODS: A retrospective clinical review was made of 90 consecutive patients who experienced a Hunt and Hess Grade I through III aneurysmal SAH and were treated with nimodipine for 15 days or less. CONCLUSIONS: None of the patients studied suffered a delayed neurological deficit as a result of the abbreviated course of nimodipine. PMID- 9950488 TI - Outcomes after stereotactically guided pallidotomy for advanced Parkinson's disease. AB - OBJECT: Parkinson's disease (PD) is a prevalent neurodegenerative disorder that becomes refractory to medication as the disease progresses. Although in the past 5 years increasing numbers of patients have undergone stereotactically guided posteroventral pallidotomy for advanced PD, the safety and efficacy of surgery remains to be documented. The goal in this study was to determine the potential operative morbidity and types of functional outcomes by using validated PD rating scales and a patient survey. METHODS: In a prospective analysis of a consecutive surgical series the authors evaluated 58 patients with advanced PD who ranged in age from 40 to 79 years (mean 67 years) and who had undergone surgery between 1994 and 1997. They used a patient survey and the Unified Parkinson's Disease Rating Scale (UPDRS) to study patients during periods of medication administration ("on") and withdrawal ("off"; mean off score before surgery = 96). Temporary surgical morbidity was found in four patients (6.9%), three of whom developed transient dysarthria and one of whom exhibited transient confusion (1.7%). One patient had persistent dysarthria (1.7%). No patient developed a visual field deficit or sustained a brain hemorrhage. All patients were discharged from the hospital within 24 hours. Significant postsurgical improvements were noted in the UPDRS off-period total and motor scores, as well as in tremor, rigidity, bradykinesia, and contralateral dyskinesia (p < 0.005). Improvements persisted in dyskinesia and tremor for the 21 patients who were evaluated past 1 year. The authors found no improvement in any on-period symptoms except dyskinesia. Thirty-one (61 %) of 51 patients surveyed reported functional gains and/or dramatic improvement in symptoms, 17 (33%) reported symptomatic improvement without functional gains, and three (6%) had minimal or no change in symptoms. No change in the mini mental state examination score was noted during follow up. There were no significant postoperative changes in the use of medication. CONCLUSIONS: In advanced PD associated with either a medically refractory state with significant off periods or levodopa-induced dyskinesias, magnetic resonance imaging-guided pallidotomy with macrostimulation was associated with minimal morbidity and yet significantly reduced dyskinesia and off-period disability. These improvements were of value to the patient and persisted beyond the 1st year. PMID- 9950490 TI - Embolization of incidental cerebral aneurysms by using the Guglielmi detachable coil system. AB - OBJECT: Guglielmi detachable coil (GDC) technology is a valuable therapeutic alternative to the surgical treatment of ruptured or incidental intracranial aneurysms. The authors describe their technical and clinical experience in the use of the GDC technique in patients who underwent endovascular occlusion for the treatment of incidentally found intracranial aneurysms. METHODS: One hundred fifteen patients with 120 incidentally found intracranial aneurysms underwent embolization by means of the GDC endovascular technique. Ninety-one patients were females and 24 were males. Patient age ranged from 13 to 80 years. In 64 patients the incidental aneurysms were discovered when unrelated nonneurological conditions signaled the need for angiography or magnetic resonance angiography (Group 1). Twenty patients who presented with incidental aneurysms that were discovered during treatment for an acutely ruptured aneurysm underwent treatment of both types of aneurysm during the acute phase of subarachnoid hemorrhage (SAH) (Group 2). Sixteen patients with incidental aneurysms were treated during the chronic phase of SAH (Group 3). Group 4 included 15 patients who had incidental aneurysms associated with brain tumors or arteriovenous malformations. Angiographic results revealed complete or near-complete occlusion in 109 aneurysms (91%) and incomplete occlusion in five aneurysms (4%). Guglielmi detachable coil embolization was attempted unsuccessfully in six aneurysms (5%). One hundred nine patients (94.8%) remained neurologically intact or unchanged from their initial clinical status. Five patients (4.3%) deteriorated as a result of immediate procedural complications. All these complications occurred in the first 50 patients treated in the series. No clinical complications were observed in the last 65 patients. In one patient, a partially embolized aneurysm ruptured 3 years postprocedure. In Groups 1 and 3, the average length of hospitalization was 3.3 days. CONCLUSIONS: The evolution of GDC technology has proved to provide safe treatment of incidental aneurysms (a morbidity rate of 0% was achieved in the last 65 patients). The topography of the aneurysm and the clinical condition of the patient did not influence final anatomical or clinical outcomes. The GDC technology also confers a positive economic impact by decreasing hospital length of stay and by eliminating the need for postembolization intensive care. PMID- 9950491 TI - Trigeminocardiac reflex during surgery in the cerebellopontine angle. AB - OBJECT: In different experimental studies authors have analyzed the autonomic responses elicited by the electrical, mechanical, or chemical stimulation of the trigeminal nerve system. The trigeminocardiac reflex (TCR) is a well-recognized phenomenon that consists of bradycardia, arterial hypotension, apnea, and gastric hypermotility. It occurs during ocular surgery and during other manipulations in and around the orbit. Thus far, it has not been shown that central stimulation of the trigeminal nerve can also cause this reflex. METHODS: The TCR was defined as clinical hypotension with a drop in mean arterial blood pressure (MABP) of more than 20% and bradycardia lower than 60 beats/minute. Pre-, intra-, and postoperative heart rate (HR) and MABP were reviewed retrospectively in 125 patients who underwent surgery for tumors of the cerebellopontine angle (CPA), and they were divided into two groups on the basis of the occurrence of the TCR during surgery. Of the 125 patients, 14 (11%) showed evidence of the TCR during dissection of the tumor near the trigeminal nerve at the brainstem. Their HRs fell 38% and their MABPs fell 48% during operative procedures as compared with preoperative levels. After cessation of manipulation, the HRs and the MABPs returned to preoperative levels. Risk factors for the occurrence of the TCR were compared with results from the literature. CONCLUSIONS: The authors' results show the possibility of occurrence of a TCR during manipulation of the central part of the trigeminal nerve when performing surgery in the CPA. PMID- 9950492 TI - Dutch Normal-Pressure Hydrocephalus Study: the role of cerebrovascular disease. AB - OBJECT: This study was conducted to determine the prevalence of cerebrovascular disease and its risk factors among patients with normal-pressure hydrocephalus (NPH) and to assess the influence of these factors on the outcome of shunt placement. METHODS: A cohort of 101 patients with NPH underwent shunt placement and was followed for 1 year. Gait disturbance and dementia were quantified using an NPH scale and handicap was determined using a modified Rankin scale (mRS). Primary outcome measures consisted of the differences between preoperative and last NPH scale and mRS scores. The presence of risk factors such as hypertension, diabetes mellitus, cardiac disease, peripheral vascular disease, male gender, and advancing age was recorded. Cerebrovascular disease was defined as a history of stroke or a computerized tomography (CT) scan revealing infarcts or moderate-to severe white matter hypodense lesions. The prevalence of risk factors for cerebrovascular disease was higher in the 45 patients with cerebrovascular disease than the 56 without it. Risk factors did not influence outcome after shunt placement. Intent-to-treat analysis revealed that the mean improvement in the various scales was significantly less for patients with a history of stroke (14 patients), CT scans revealing infarctions (13), or white matter hypodense lesions (32 patients) than for those without cerebrovascular disease. The proportion of patients who responded to shunt placement was also significantly lower among patients with than those without cerebrovascular disease (p=0.02). CONCLUSIONS: The authors identified a subgroup of patients with NPH and cerebrovascular disease who showed disappointing results after shunt placement. Cerebrovascular disease was an important predictor of poor outcome. PMID- 9950493 TI - Sylvian aqueduct syndrome and global rostral midbrain dysfunction associated with shunt malfunction. AB - OBJECT: This study is a retrospective analysis of clinical data obtained in 28 patients affected by obstructive hydrocephalus who presented with signs of midbrain dysfunction during episodes of shunt malfunction. METHODS: All patients presented with an upward gaze palsy, sometimes associated with other signs of oculomotor dysfunction. In seven cases the ocular signs remained isolated and resolved rapidly after shunt revision. In 21 cases the ocular signs were variably associated with other clinical manifestations such as pyramidal and extrapyramidal deficits, memory disturbances, mutism, or alterations in consciousness. Resolution of these symptoms after shunt revision was usually slow. In four cases a transient paradoxical aggravation was observed at the time of shunt revision. In 11 cases ventriculocistemostomy allowed resolution of the symptoms and withdrawal of the shunt. Simultaneous supratentorial and infratentorial intracranial pressure recordings performed in seven of the patients showed a pressure gradient between the supratentorial and infratentorial compartments, with a higher supratentorial pressure before shunt revision. Inversion of this pressure gradient was observed after shunt revision and resolution of the gradient was observed in one case after third ventriculostomy. In six recent cases, a focal midbrain hyperintensity was evidenced on T2-weighted magnetic resonance imaging sequences at the time of shunt malfunction. This rapidly resolved after the patient underwent third ventriculostomy. CONCLUSIONS: It is probable that in obstructive hydrocephalus, at the time of shunt malfunction, the development of a transtentorial pressure gradient could initially induce a functional impairment of the upper midbrain, inducing upward gaze palsy. The persistence of the gradient could lead to a global dysfunction of the upper midbrain. Third ventriculostomy contributes to equalization of cerebrospinal fluid pressure across the tentorium by restoring free communication between the infratentorial and supratentorial compartments, resulting in resolution of the patient's clinical symptoms. PMID- 9950494 TI - Surgical treatment of craniopharyngiomas: experience with 168 patients. AB - OBJECT: The goal of this study was to assess the outcome of surgical management in 168 consecutive patients harboring craniopharyngiomas treated between January 1983 and April 1997. METHODS: In 148 patients undergoing initial (primary) surgery, the pterional approach was most frequently used (39.2%), followed by the transsphenoidal approach (23.6%). For large retrochiasmatic craniopharyngiomas, the bifrontal interhemispheric approach was used increasingly over the pterional approach and led to improved surgical results. Total tumor removal was accomplished in 45.7% of transcranial and 85.7% of transsphenoidal procedures. The main reasons for incomplete removal were attachment to and/or infiltration of the hypothalamus, major calcifications, and attachment to vascular structures. The success rate in total tumor removal was inferior in the cases of tumor recurrence. The operative mortality rate in transcranial surgery was 1.1% in primary cases and 10.5% in cases of tumor recurrence. No patient died in the group that underwent transsphenoidal surgery. The rate of recurrence-free survival after total removal was 86.9% at 5 years and 81.3% at 10 years. In contrast, the 5-year recurrence-free survival rate was only 48.8% after subtotal removal and 41.5% after partial removal. Following primary surgery, the actuarial survival rate was 92.7% at 10 years, with the best results after complete tumor removal. At last follow up, 117 (79%) of 148 patients who underwent primary surgery were independent and without impairment. CONCLUSIONS: Total tumor removal while avoiding hazardous intraoperative manipulation provides favorable early results and a high rate of long-term control in craniopharyngiomas. PMID- 9950495 TI - Surgical treatment of craniopharyngiomas: endocrinological results. AB - OBJECT: This study aimed to elucidate the endocrinological outcome of craniopharyngioma surgery. In particular, endocrinological results were analyzed in relation to the surgical approach. The study includes 143 patients who underwent pre- and postoperative endocrinological assessment and who had not previously undergone surgery. METHODS: Diabetes insipidus was the most common postoperative deficiency in both the transcranial and transsphenoidal groups. The overall percentage of patients with diabetes insipidus increased from 16.1% preoperatively to 59.4% postoperatively. After transcranial surgery, the rate of anterior pituitary deficiency also increased. However, normal preoperative anterior pituitary function was maintained in more than 50% of patients for each endocrine axis. Similar results were attained in the group of patients undergoing complete tumor removal. The best result was achieved for gonadal function: the incidence of hypogonadism increased only slightly from 77.4 to 79.8%. The rate of anterior pituitary failure at presentation was much higher in the transsphenoidal than in the transcranial group. During transsphenoidal surgery, intact anterior pituitary functions were generally preserved. The rate of panhypopituitarism increased only slightly, from 40% before surgery to 42.9% after surgery. Endocrinological results were not inferior in patients with a ventrally displaced pituitary. This variant required midline incision of the gland for exposure of the craniopharyngioma. In the entire series of 143 patients the pituitary stalk was generally preserved. Postoperative panhypopituitarism was encountered in only one of eight patients in whom the pituitary stalk was partially resected because of tumor infiltration. None of the 88 patients who remained recurrence-free demonstrated endocrinological deterioration during follow-up review, compared with the early postoperative assessment 3 months postsurgery. On the other hand, complete recovery of one endocrine axis was observed in nine of these patients during later follow-up evaluations. In five of them, diabetes insipidus had regressed. CONCLUSIONS: It is worth preserving the pituitary stalk and gland at surgery because of the definite chance that intact anterior pituitary functions can be maintained. Postoperative diabetes insipidus must be accepted as a common sequela following attempts at complete removal of the craniopharyngioma. PMID- 9950496 TI - Pathogenesis of intracranial germ cell tumors reconsidered. AB - OBJECT: To determine the pathogenesis of intracranial germ cell tumors (GCTs), the author studied 153 cases of these tumors encountered through 1994, 62.7% of which showed monotypic histological patterns and 37.3% of which were shown to be mixed tumors. METHODS: Six patients died soon after admission and underwent autopsy; the other patients underwent surgery followed by radio- and/or chemotherapy. One hundred thirty-four cases were followed through the end of 1997. All patients with a choriocarcinoma died within 1 year. Patients with a yolk sac tumor (endodermal sinus tumor) or an embryonal carcinoma also had poor outcomes. Patients with a mature teratoma had 5- and 10-year survival rates of 93% each. Patients with an immature teratoma had 5- and 10-year survival rates of 86% each, whereas patients who had a teratoma with malignant transformation had a 3-year survival rate of 50%. Patients with a germinoma had a 5-year survival rate of 96% and a 10-year survival rate of 93%. These results may bring into question the validity of the germ cell theory because germinoma, which should be the most undifferentiated tumor according to the theory, was the most benign and choriocarcinoma and yolk sac tumor (endodermal sinus tumor), which should be the most differentiated tumors, were the most malignant according to results obtained during the follow-up study. CONCLUSIONS: Germ cell tumors other than germinomas may not originate from one single type of cell (primordial germ cells). The embryonic cells of various stages of embryogenesis may perhaps be misplaced in the bilaminar embryonic disc at the time of the primitive streak formation, becoming involved in the stream of lateral mesoderm and carried to the neural plate area to become incorrectly enfolded into the brain at the time of neural tube formation. The author propounds the following hypothesis: tumors composed of cells resembling the cells that appear in the earlier stages of embryogenesis (ontogenesis) are more malignant than those composed of cells resembling the cells that appear in the later stages of embryogenesis. PMID- 9950497 TI - Benign cerebellar astrocytomas in children. AB - OBJECT: Cerebellar astrocytomas are benign tumors of childhood known to be associated with excellent long-term survival in patients in whom complete surgical resection is possible. However, the roles of other factors--clinical, radiological, histological, and therapeutic--in the survival of the patient, tumor recurrence, and long-term patient outcome remain imprecise. The goal of this study was to examine these factors and their relationships. METHODS: To clarify these issues a retrospective review was conducted of 168 children who were surgically treated for a cerebellar astrocytoma at Hopital Necker-Enfants Malades between 1955 and 1995. These patients' clinical files were examined, the histological characteristics of their tumors were reviewed, and their outcomes were assessed according to Bloom's scale and the Wechsler intelligence quotient test. Of the 168 patients in the study, 91 were male and 77 were female with a mean age of 6.9 years and a mean follow up lasting 7.7 years. Tumors were identified as being strictly located in the cerebellum in 76.2% of the patients and as involving the brainstem (referred to as the "transitional form") in 23.8% of the patients. Complete surgical excision was possible in 88.7% of cases. There was a total mortality rate of 4.2% and a tumor recurrence rate of 9.5%. Fifty eight percent of the patients had no neurological sequelae at follow-up evaluation. Pejorative factors that were discovered by multivariate analysis to be important included: a long preoperative duration of symptoms and the transitional form of tumor with respect to survival; incomplete tumor excision with respect to an increased risk of recurrence; and a long preoperative duration of symptoms, an early epoch during which surgery was performed (1955-1974), severe ventricular dilation, and the transitional form of tumor with respect to a poorer long-term patient outcome. CONCLUSIONS: The presence of brainstem involvement (tumor in the transitional form) emerged as a significant negative prognostic factor and should be treated as a distinct nosological entity. The extent of surgical excision has a significant bearing on the risk of tumor recurrence. PMID- 9950498 TI - Epilepsy in children with shunted hydrocephalus. AB - OBJECT: The incidence of epilepsy among children with hydrocephalus and its relation to shunts and their complications, raised intracranial pressure (ICP), and developmental outcome are explored in a retrospective study. METHODS: The authors studied a series of 802 children with hydrocephalus due to varying causes, who were treated by ventriculoperitoneal shunt placement between 1980 and 1990, with a mean follow-up period of 8 years. Patients who had tumoral hydrocephalus and those whose files lacked significant data were excluded. Data extracted from medical records, including history of the hydrocephalus and history of seizures, if any, were analyzed. Thirty-two percent of the children had epilepsy, the onset of which frequently occurred at approximately the same time that the diagnosis of hydrocephalus was made. The majority of the affected children had severe uncontrolled epilepsy. The incidence of epilepsy was significantly affected by the original cause of the hydrocephalus. The presence of radiological abnormalities was also found to be a significant predictor of epilepsy. Similarly, shunt complications predisposed to epilepsy. Episodes of raised ICP related to hydrocephalus or in association with shunt malfunction may also predispose to epileptic seizures. Furthermore, the presence of a shunt by itself seems able to promote an epileptogenic focus. Finally, epilepsy appears to be an important predictor of poor intellectual outcome in hydrocephalic children with shunts. CONCLUSIONS: A prospective study is needed to identify clearly and confirm avoidable factors predisposing to seizures in these children so that we can strive to reduce the incidence of these seizures and, subsequently, improve these children's quality of life. PMID- 9950499 TI - Bilateral decrease in interictal hippocampal blood flow in unilateral mesiotemporal epilepsy. AB - OBJECT: The goal of this study was to determine whether regional cerebral blood flow (rCBF) changes that were found contralaterally to a verified unilateral epileptic focus were associated with the spatiotemporal organization of epileptic abnormalities. METHODS: The CBF in both hippocampi was assessed using stable Xe enhanced computerized tomography in a series of 19 patients with unilateral mesiotemporal epilepsy. Results were compared according to the distribution of interictal spiking and the spatiotemporal organization of the ictal discharges as determined by stereoelectroencephalography. Two groups were defined: in Group 1 (nine patients), the discharge remained unilateral; in Group 2 (10 patients), the discharge spread to contralateral mesiotemporal structures. For Group 1, the rates of ipsi- and contralateral hippocampal blood flow (HBF) were 32.88+/-15.53 and 45.88+/-17.19 ml/100 g/minute, respectively, whereas in Group 2 they were 36.7+/-11.54 and 36.4+/-11.27 ml/100 g/minute (mean+/-standard deviation). A two way analysis of variance combining type of seizure (Group 1 compared with Group 2) and HBF (ipsi- compared with contralateral absolute values) demonstrated a main effect for HBF (F[1,17] = 5.051; p = 0.0382), a significant interaction between the two factors (F[1,17] = 6.188; p = 0.0235), and no main effect for type of seizure (F[1,17] = 0.258; p = 0.6178). CONCLUSIONS: In unilateral mesiotemporal epilepsy, asymmetrical interictal hippocampal perfusion was correlated with restricted unilateral ictal discharges, whereas bilateral hippocampal hypoperfusion was correlated with ictal discharges spreading to the contralateral mesiotemporal structures. The lack of correlation between the degree of hypoperfusion and the percentage of neuron cell loss indicated that the decrease in rCBF has both functional and lesional origins. PMID- 9950500 TI - Combining endovascular and neurosurgical treatments of high-risk dural arteriovenous fistulas in the lateral sinus and the confluence of the sinuses. AB - OBJECT: The authors describe the use of a systemic approach to treat dural arteriovenous fistulas (DAVFs) in the lateral sinus and the confluence of sinuses in 17 patients who presented with signs and symptoms related to intracranial hemorrhage, infarction, and diffuse brain swelling. METHODS: Angiographic examination revealed three different types of DAVFs in these high-risk patients: 1) extremely high flow DAVF not associated with sinus occlusion or leptomeningeal retrograde venous drainage (LRVD); 2) localized DAVF with exclusive LRVD and without sinus occlusion; and 3) diffuse DAVF with sinus occlusion and LRVD. Because of the complex nature of these lesions, the authors adopted a staged protocol in which they combined endovascular and surgical treatments. CONCLUSIONS: The authors believe that by close collaboration between endovascular therapists and vascular neurosurgeons, high-risk DAVFs in the lateral sinus and the confluence of sinuses can be successfully managed without treatment-related morbidity and mortality. PMID- 9950501 TI - Early changes measured by magnetic resonance imaging in cerebral blood flow, blood volume, and blood-brain barrier permeability following dexamethasone treatment in patients with brain tumors. AB - OBJECT: In this study the authors assessed the early changes in brain tumor physiology associated with glucocorticoid administration. Glucocorticoids have a dramatic effect on symptoms in patients with brain tumors over a time scale ranging from minutes to a few hours. Previous studies have indicated that glucocorticoids may act either by decreasing cerebral blood volume (CBV) or blood tumor barrier (BTB) permeability and thereby the degree of vasogenic edema. METHODS: Using magnetic resonance (MR) imaging, the authors examined the acute changes in CBV, cerebral blood flow (CBF), and BTB permeability to gadolinium diethylenetriamine pentaacetic acid after administration of dexamethasone in six patients with brain tumors. In patients with acute decreases in BTB permeability after dexamethasone administration, changes in the degree of edema were assessed using the apparent diffusion coefficient of water. CONCLUSIONS: Dexamethasone was found to cause a dramatic decrease in BTB permeability and regional CBV but no significant changes in CBF or the degree of edema. The authors found that MR imaging provides a powerful tool for investigating the pathophysiological changes associated with the clinical effects of glucocorticoids. PMID- 9950502 TI - Multiple genetic aberrations including evidence of chromosome 11q13 rearrangement detected in pituitary adenomas by comparative genomic hybridization. AB - OBJECT: This study was conducted to determine whether comparative genomic hybridization (CGH) is a more sensitive method for detecting genetic aberrations than other tests currently in use. METHODS: The authors used CGH to examine 40 primary and 13 recurrent adenomas obtained from 52 patients for loss and gain of genetic material. Copy number aberrations (CNAs) were detected in 25 (48%) of the 52 patients studied. The chromosomes affected were, in order of decreasing frequency, 11, 7, X, 1, 8, 13, 5, 14, 2, 6, 9, 10, 12, 3, 18, 21, 4, 16, 15, 19, 22, and Y. Endocrinologically active adenomas were more likely to contain (p = 0.009) and had a greater number (p = 0.003) of CNAs. Of 26 adenomas with CNAs, 18 showed multiple aberrations involving entire chromosomes or chromosome arms. The most frequent CNA involving a chromosome subregion, which was present in four (8%) of 53 adenomas, was the loss of all chromosome 11 material except for a preserved common segment containing 11q13. Immunoperoxidase staining did not detect cyclin D1 expression in those four cases, making cyclin D1 an unlikely target of this rearrangement. CONCLUSIONS: These findings indicate that genetic abnormalities are present in pituitary adenomas at a higher rate than previously reported, are associated with endocrinological activity, and often involve several chromosomes. Rearrangement at 11q13 may inactivate a tumor suppressor gene or activate an oncogene that is important in the initiation or progression of sporadic pituitary adenomas. PMID- 9950503 TI - Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration, and tissue cannula sealing time. AB - OBJECT: Although recent studies have shown that convection can be used to distribute macromolecules within the central nervous system (CNS) in a homogeneous, targeted fashion over clinically significant volumes and that the volume of infusion and target location (gray as opposed to white matter) influence distribution, little is known about other factors that may influence optimum use of convection-enhanced distribution. To understand the variables that affect convective delivery more fully, we examined the rate of infusion, delivery cannula size, concentration of infusate, and preinfusion sealing time. METHODS: The authors used convection to deliver 4 microl of 14C-albumin to the striatum of 40 rats. The effect of the rate of infusion (0.1, 0.5, 1, and 5 microl/minute), cannula size (32, 28, and 22 gauge), concentration of infusate (100%, 50%, and 25%), and preinfusion sealing time (0 and 70 minutes) on convective delivery was examined using quantitative autoradiography, National Institutes of Health image analysis software, scintillation analysis, and histological analysis. Higher rates of infusion (1 and 5 microl/minute) caused significantly (p < 0.05) more leakback of infusate (22.7+/-11.7% and 30.3+/-7.8% [mean+/-standard deviation], respectively) compared with lower rates (0.1 microl/minute [4+/-3.6%] and 0.5 microl/minute [5.2+/-3.6%]). Recovery of infusate was significantly (p < 0.05) higher at the infusion rate of 0.1 microl/minute (95.1+/-2.8%) compared with higher rates (85.2+/-4%). The use of large cannulae (28 and 22 gauge) produced significantly (p < 0.05) more leakback (35.7+/-8.1% and 21.1+/-7.5%, respectively) than the smaller cannula (32 gauge [5.2+/-3.6%]). Varying the concentration of the infusate and the preinfusion sealing time did not alter the volume of distribution, regional distribution, or infusate recovery. CONCLUSIONS: Rate of infusion and cannula size can significantly affect convective distribution of molecules, whereas preinfusion sealing time and variations in infusate concentration have no effect in this small animal model. Understanding the parameters that influence convective delivery within the CNS can be used to enhance delivery of potentially therapeutic agents in an experimental setting and to indicate the variables that will need to be considered for optimum use of this approach for drug delivery in the clinical setting. PMID- 9950504 TI - Comparison of 14C-sucrose delivery to the brain by intravenous, intraventricular, and convection-enhanced intracerebral infusion. AB - OBJECT: The authors evaluated convection-enhanced delivery (CED) of 14C-sucrose to the rat brain as a method of enhancing cerebral drug delivery and compared it with intravenous (i.v.) and intraventricular (i.v.t.) routes of administration. METHODS: Groups of rats received 14C-sucrose by bolus i.v. infusion, i.v.t. infusion for 1, 2, or 7 days at 0.17 microl/minute, or CED at rates from 0.01 to 0.5 microl/minute for periods from 1 hour to 7 days. Radioisotope distribution and concentration in tissue were analyzed using quantitative autoradiography. Intravenously administered sucrose reached the entire brain, but levels in tissue were low. After i.v.t. administration, sucrose levels in tissue were high at, and declined exponentially away from, the ventricular surface. Chronic CED administration maintained high levels of sucrose in tissue that focally were up to 10,000 times higher than in the i.v. group. The isotope distribution pattern after chronic CED infusions indicated a central component that resulted from convention and a peripheral component in gray matter that was the result of diffusion. The brain influx (0.42 microl/g/min) and diffusion constants of sucrose (2.8 x 10(-6) cm2/second) were similar to reported values. The total brain efflux constant was 0.0044 minute, whereas the blood-brain barrier (BBB) efflux constant was 0.0016 minute. There were no pathological changes in the brains after CED except those associated with cannula insertion. Sucrose, which was thought to be inert, was found to interact with brain tissue; up to 25% was bound to an unidentified tissue component. CONCLUSIONS: Chronic CED appears to be a potentially useful method for significantly circumventing the BBB and increasing delivery of water-soluble drugs to the brain. PMID- 9950505 TI - A comparative study of the effects of two nitric oxide synthase inhibitors and two nitric oxide donors on temporary focal cerebral ischemia in the Wistar rat. AB - OBJECT: A critical review of the literature indicates that the effects of nitric oxide synthase (NOS) inhibitors on focal cerebral ischemia are contradictory. In this experiment the authors methodically examined the dose-dependent effects of two NOS inhibitors and two NO donors on cortical infarction volume in an animal model of temporary focal cerebral ischemia simulating potential ischemia during neurovascular interventions. METHODS: Ninety-two Wistar rats underwent 3 hours of combined left middle cerebral artery and bilateral common carotid artery occlusion after having been anesthetized with 1% halothane. A nonselective NOS inhibitor, N(G)-nitro-L-arginine-methyl-ester (L-NAME), and two NO donors, 3 morpholinosydnonimine hydrochloride and NOC-18, DETA/NO, (Z)-1-[2(2-aminoethyl)-N (2-ammonioethyl)amino]diazen-1-i um-1,2-diolate, were administered intravenously 30 minutes before ischemia was induced. A selective neuronal NOS inhibitor, 7 nitroindazole (7-NI), was administered intraperitoneally in dimethyl sulfoxide (DMSO) 60 minutes before ischemia was induced. Two ischemic control groups, to which either saline or DMSO was administered, were also included in this study. Seventy-two hours after flow restoration, the animals were perfused with tetrazolium chloride for histological evaluation. Cortical infarction volume was significantly reduced by 71% in the group treated with 1 mg/kg L-NAME when compared with the saline-treated ischemic control group (27.1+/-37 mm3 compared with 92.5+/-26 mm3, p < 0.05). The NOS inhibitor 7-NI significantly reduced cortical infarction volume by 70% and by 92% at doses of 10 and 100 mg/kg: 35.2+/ 32 mm3 (p < 0.05) and 9+/-13 mm3 (p < 0.005), respectively, when compared with the DMSO-treated ischemic control group (119+/-43 mm3). There was no significant difference between the saline-treated and DMSO-treated ischemic control groups. Treatment with NO donors did not significantly alter cortical infarction volume. CONCLUSIONS: These results support an important role for NO in ischemic neurotoxicity and indicate that neuronal NOS inhibition may be valuable in reducing cortical injury in patients suffering temporary focal cerebral ischemia during neurovascular procedures. PMID- 9950507 TI - Central neurocytoma: morphological, flow cytometric, polymerase chain reaction, fluorescence in situ hybridization, and karyotypic analyses. Case report. AB - The results of cytogenetic and molecular genetic analysis of a central neurocytoma are presented. Central neurocytomas are intriguing neoplasms that exhibit primarily neuronal, but also glial characteristics, which indicate an origin from a pluripotential neuroglial precursor. The authors describe an intraventricular neurocytoma in an 11-year-old boy that showed anaplastic features with widespread necrosis and mitoses, as well as extensive calcification and foci that exhibited marked neuronal differentiation with clusters of ganglion cells. Immunohistochemical examination showed prominent synaptophysin and neurofilament positivity and focal glial fibrillary acidic protein positivity. Electron microscopy revealed abundant neuritic processes with microtubules and dense core granules as well as mature ganglion cells. Flow cytometry studies revealed increased S (7.8%) and G2M (9.7%) phase components. Molecular and cytogenetic studies were undertaken to assess whether there were similarities to two other tumor types that exhibit neuronal differentiation, the neuroblastoma and medulloblastoma. Polymerase chain reaction and fluorescence in situ hybridization (FISH) analysis revealed no evidence of amplification of the MYCN oncogene or chromosome 1p deletion, which are common in neuroblastomas. Chromosomal analysis by G banding revealed a complex karyotype, with counts in the near-diploidy range (45-48). Two chromosomes 1 appeared normal on G banding and FISH analysis, with p58 signals present on the distal p arm of both chromosomes 1; however, three additional copies of distal 1q were present in rearrangements with 4 and 7. Although the histological findings indicate a kinship to the neuroblastoma and medulloblastoma, the central neurocytoma appears to have a different karyotypic profile, although more cases need to be assessed using molecular genetic analysis. PMID- 9950506 TI - Hypothermia: depression of tricarboxylic acid cycle flux and evidence for pentose phosphate shunt upregulation. AB - OBJECT: Hypothermia is used in neurosurgery and other surgical disciplines to reduce tissue injury, but the mechanism of such protection remains elusive. The authors have endeavored to delineate the mechanism of neural protection afforded by hypothermia through a study of glucose metabolism. METHODS: Nuclear magnetic resonance spectroscopy was used to follow the carbon-13 label from [1-13C]glucose as it was metabolized through the glycolytic and tricarboxylic acid pathways. Male Sprague-Dawley rats were maintained at either 37.5 degrees C or 31 degrees C and infused with labeled glucose for 10, 30, 60, 100, or 200 minutes (five rats were used for each time point and for each temperature). At the end of the infusion period, the rats' brains were subjected to rapid freeze-funnel fixation. Water-soluble metabolites were extracted from samples of the neocortex and hippocampus by using perchloric acid extraction. The fractional enrichment of these metabolites was used to calculate the reaction rate constant of formation and steady-state enrichment for a number of metabolites. Hypothermia resulted in a 30 to 40% depression of metabolism (p < 0.0001) in both the neocortex and hippocampus. Steady-state fractional enrichment of metabolites was also decreased by 20 to 25% with hypothermia (p < 0.0001), implying a loss of label during metabolism. CONCLUSIONS: The results of this study suggest that an increased fraction of glucose metabolism was shunted through the pentose phosphate pathway in the presence of hypothermia. PMID- 9950508 TI - Malignant intravascular lymphomatosis associated with venous stenosis. Case report. AB - This 55-year-old man presented with malignant intravascular lymphomatosis, a rare vascular disorder of the central nervous system characterized by proliferation of malignant lymphoma cells. The clinical manifestations were focal neurological signs and progressive dementia. Angiography demonstrated stenoses of the cortical veins. Postmortem examination revealed infiltration of tumor cells into the lumen and vascular wall, although the stenoses were caused primarily by fibrin thrombi. To the authors' knowledge this is the first case of malignant intravascular lymphomatosis associated with venous stenosis. PMID- 9950509 TI - Hemangiopericytoma of the third ventricle. Case report. AB - The authors present the first reported case of a hemangiopericytoma (HPC) occurring in the third ventricle. Most of these lesions are based in the meninges. There is only one other reported case of an intraventricular HPC; in that case the lesion was found in the lateral ventricle. A 40-year-old right handed man presented with a 3-month history of headaches. Clinical evaluation, including computerized tomography and magnetic resonance imaging studies, revealed a 1-cm enhancing lesion in the third ventricle. Given the findings on the preoperative imaging studies, the lesion was not consistent with some of the more commonly occurring tumors of the third ventricle, namely colloid cysts. A transcortical approach and resection of the lesion was performed without complication. The final pathological findings were consistent with those of an HPC. Hemangiopericytomas rarely occur in the ventricles and may pose a difficult diagnostic dilemma based on their radiographic and gross appearances, as shown in this case. Because of this difficulty, histological confirmation is required to make a definitive diagnosis. These lesions have a propensity to recur and metastasize in the central nervous system and periphery, thus making the goal of treatment a complete surgical resection followed by postoperative radiation therapy in most cases. PMID- 9950510 TI - Optic chiasm diastasis in a pituitary tumor. Case illustration. PMID- 9950511 TI - The peer-review process of the Journal of Neurosurgery. AB - Peer review is the process by which scientific articles are evaluated and selected for publication. To clarify this procedure for readers and writers, the authors present a detailed description of peer review at the Journal of Neurosurgery (JNS) in the context of other journals. They discuss the unique characteristics of JNS's peer-review process and how it contributes to the quality of the JNS. PMID- 9950512 TI - Clinical examination and shunt failure. PMID- 9950513 TI - Reversal of vasospasm. PMID- 9950514 TI - Catamenial mononeuropathy and radiculopathy. PMID- 9950515 TI - Hearing preservation in vestibular schwannoma surgery. PMID- 9950517 TI - Vertebral artery injury with transarticular screws. PMID- 9950516 TI - Evoked potentials. PMID- 9950518 TI - Scientific Program of the 1999 Annual Meeting of the American Association of Neurological Surgeons. Ernest N. Morial Convention Center, New Orleans, Louisiana. April 24-29, 1999. PMID- 9950519 TI - Large arteriovenous malformations of the face: aesthetic results with recurrence control. AB - Large facial arteriovenous malformations are problematic for patients because of grotesque disfigurement, risk of rapid enlargement, and life-threatening rupture. Successful treatment of these relentless complex lesions is one of the most difficult challenges facing plastic surgeons. From a series of 300 large facial arteriovenous malformations, 85 patients were treated with embolization and excision; six of these cases (representing six separate anatomic regions: labial, auricular, eyelid, cheek, chin, and occipitoparietal) were selected for review. The purpose of this article was to look critically at the management of these six facial arteriovenous malformations, including patient presentation, angiographic procedures, surgical planning and technique, and postoperative long-term follow up care. Lessons learned from the six representative cases provide clues for the management of large facial arteriovenous malformations and demonstrate the possibilities of recurrence and their occasionally relentless behavior. The cases show that long-term control of these lesions with acceptable aesthetic results can be achieved. The mainstay of treatment includes the following: (1) selective intra-arterial embolization with fine catheters and direct lesional embolization; (2) judicious resection and reconstruction with local or expanded tissue flaps; and (3) careful follow-up with serial examinations, duplex, and arteriography. PMID- 9950520 TI - Successful distraction osteogenesis across a growing cranial suture without an osteotomy. AB - The application of distraction osteogenesis to the membranous bones of the craniofacial skeleton and its effects on cranial volume and overall skull shape have not been fully studied. This pilot study was designed to compare distraction of a cranial suture in the rabbit model with distraction across an osteotomy and to evaluate the response of the suture both grossly and histologically. Additionally, the need for a period of rigid fixation after distraction was evaluated. Calibrated distraction of either the coronal suture or an osteotomy in the midsection of the parietal bone using an internal distractor (Synthes Maxillofacial, Paoli, Pa.) was studied in juvenile and adult New Zealand White rabbits. Skull growth and distraction were followed by serial cephalograms, and bone biopsies of the distracted sites were obtained after death for histologic evaluation. Craniometric analysis of the skulls was also performed. There was significantly greater mean marker separation in the juvenile suture distraction group (6.6 +/- 0.2 mm; n = 3) than in the control group (2.2 +/- 0.2 mm; p < 0.01). Marker separation was also significantly greater across the parietal osteotomy (6.4 +/- 0.1 mm) than in the sham group (no marker separation). Craniometric data demonstrated the ability of the juvenile skull to distribute the change at the coronal suture throughout the skull to maintain symmetry and minimize disproportion. No distraction was obtained across the adult suture. In the juvenile suture distraction group without a period of stable fixation, a relapse of 17 +/- 6 percent was noted after 1 week, an additional 2.3 +/- 0.5 percent after the second week, and no further change in the third postdistraction week (n = 2; p < 0.01). These results show that in this animal model, distraction osteogenesis can be achieved across a growing cranial suture without an osteotomy or suturectomy and that the degree of distraction and new bone formation is comparable to that across an osteotomy. This suggests that cranial expansion can be obtained in a growing animal without using a more invasive cranial osteotomy. Additionally, the first week after distraction seems to be the most critical time period to maintain stable fixation. PMID- 9950522 TI - Analysis and treatment of severe trigonocephaly. AB - A retrospective analysis of seven patients with clinically severe trigonocephaly was performed, including a review of preoperative and postoperative computed tomography scans. A method of analyzing the trigonocephalic deformity was developed. This is based on determination of the angular severity of the forehead (110 +/- 4 degrees) and the length of half of the supraorbital bar (40 +/- 3 mm). This central angle was found to be relatively constant in this population. Using simple trigonometric relationships, a rationale for the alternative method of reconstruction used in these patients is presented. This technique is based on transverse expansion of the supraorbital bar, transposition of the lateral orbital rim, expansion of the temporal fossa, and recontouring the orbital aperture. As a separate consideration and step, the bony interorbital distance is widened. PMID- 9950521 TI - Analysis of posterior plagiocephaly: deformational versus synostotic. AB - Appropriate management of posterior plagiocephaly requires differentiation of occipitoparietal flattening caused by lambdoid synostosis from that caused by deformational forces. In a 2 1/2-year prospective study of 115 infants presenting with unilateral posterior cranial flattening, only one child had synostotic posterior plagiocephaly (lambdoid synostosis), whereas 114 infants had deformational posterior plagiocephaly. Deformational occipitoparietal flattening was more common on the right (61 percent) than on the left (30 percent), and minor contralateral frontal flattening was not unusual (52 percent). The ipsilateral ear was anteriorly displaced in virtually all infants (97 percent). Some infants had ipsilateral torticollis (19 percent); a few had contralateral torticollis (8 percent). Gender ratio was 3:1, male:female. A total of 114 infants with deformational posterior plagiocephaly were treated conservatively either by head positioning in the crib (n = 63) or with a molding helmet (n = 51). Outcome was assessed by pretreatment and posttreatment anthropometry on 53 of these infants, who were either positioned (n = 17) or helmeted (n = 36). Improvement occurred in 52 of 53 patients (mean follow-up 4.6 months), i.e., the difference in length between the long and short transcranial axis diminished in 52 infants (mean 1.2 to 0.7 cm), did not progress in any child, and was unchanged in one infant. At an average age of 10 months, posterior cranial symmetry was better in infants treated with a helmet (mean difference 0.6 cm) than in those managed by positioning (mean difference 1.0 cm) (p < 0.001). Age at initiation of helmet therapy (from 2 to 9 months) was unrelated to rate of improvement. In a 10 year retrospective study, the authors identified 12 infants who had an operation for posterior plagiocephaly. All but one had confirmed premature lambdoid fusion; thus, this condition accounted for 3.4 percent of all primary operations performed for craniosynostosis during this decade (n = 323). In retrospect, the physical findings of synostotic posterior plagiocephaly were not clearly different from those of deformational posterior plagiocephaly. Plain radiography was sometimes used to confirm the clinical diagnosis. Neither sutural narrowing, deep interdigitations, nor perisutural sclerosis indicated lambdoid synostosis. Computed tomography (CT) was necessary if the physical findings were suspicious for lambdoid synostosis or if plain films did not give a definitive diagnosis. Axial CT scans (n = 7) showed a symmetric forehead in all but one patient with lambdoid synostosis. CT studies also demonstrated that auricular position was indeterminate in synostotic posterior plagiocephaly, being anterior, posterior, or symmetric, whereas the ipsilateral ear was virtually always anterior in deformational posterior plagiocephaly. PMID- 9950523 TI - Fetal unilateral cleft lip and palate: detection of enzymic anomalies in the amniotic fluid. AB - Aims of this study were to evaluate whether it is possible to determine, by means of isoelectric focusing, an enzymic differentiation in human amniotic fluid, and whether the onset of fetal cleft lip and palate is accompanied by a pathologic enzymatic differentiation pattern in amniotic fluid. From January of 1993 to June of 1996, amniotic fluid samples from 315 healthy pregnant women (ages 22 to 43 years, mean 37 years; gestational age 14 to 22 weeks, mean 17 weeks) were examined. The normality of all pregnancies was confirmed at birth. Moreover, amniotic fluid samples were examined from three pregnancies (ages 36, 35, and 30 years; gestational ages 16, 18, 24 weeks) with fetal unilateral cleft lip and palate (confirmed at birth), diagnosed by ultrasound. The authors have tested as "metabolic" markers the enzymes lactate dehydrogenase and creatine phosphokinase. For the concentration rates of both the tested enzymes, a statistically significant difference (p = 0.003) was found between amniotic fluid samples obtained from normal and affected pregnancies. These data, in the authors' opinion, corroborate the hypothesis that a local metabolic impairment is somehow involved in the pathogenesis of cleft lip and palate. PMID- 9950524 TI - Experience with the rectus abdominis myocutaneous flap with vascularized hard tissue for immediate orbitofacial reconstruction. AB - For a considerable tissue defect of the orbitofacial region after skull base or head and neck tumor en bloc extirpation, we have developed the "flying buttress" technique using the vascularized hard tissue rather than the multi-stage operative method using bone graft or alloplastic materials. The procedure reconstructs the inferior orbital rim and the zygomatic prominence--flying buttresses bridging transversely in a missing face--with free flap coverage, simultaneously in the primary surgery so that the bony structure is maintained for years and ptosis of a large flap is minimized. We prefer to use the rectus abdominis myocutaneous flap for tissue restoration and two types of vascularized hard tissue: the costal cartilages combined with the flap and the temporalis muscle-pedicled calvarial bone. Representative cases are illustrated and the technique is detailed. PMID- 9950525 TI - Factors associated with complications in microvascular reconstruction of head and neck defects. AB - The use of microvascular free tissue transfer has allowed the reconstruction of increasingly complex defects in higher risk patients after head and neck cancer resections. However, the combination of these factors also gives rise to a higher risk for the development of complications. This study was performed to establish the pretreatment factors associated with complication development after microvascular free tissue transfer for the reconstruction of defects resulting from head and neck cancer ablations, with particular attention to the role of comorbid conditions. A retrospective cohort study was conducted including 200 consecutive microvascular free tissue transfers performed for the reconstruction of surgical defects in the head and neck region at a single tertiary care institution. Comorbidity severity was assessed using the Charlson comorbidity index, a novel approach to comorbid staging in this setting. The flap survival rate was 98 percent. Complications developed in 56 cases (28 percent), with multiple complications occurring in 21 of these cases (10.5 percent). Univariate analysis revealed that prior radiation treatment (p = 0.03), anesthesia time over 10 hours (0.05), and advanced Charlson comorbidity grade (0.002) were associated with an increased risk for the development of complications. However, only the presence of advanced Charlson grade proved significant after multivariate analysis (odds ratio 3.9; 95 percent CI = 1.5 to 10.1). In addition, increasing Charlson grade (p = 0.003) and age over 70 years (p = 0.04) correlated with increasing complication severity. Systemic complications occurred in 28 patients (14 percent), with advanced Charlson grade being the only significant factor associated with the development of complications after controlling for confounding factors (odds ratio 3.8; 95 percent CI = 1.5 to 9.7). In patients over 70 years of age, increasing operative time also impacted on the development of systemic complications (p = 0.002), especially in patients with advanced Charlson grades (0.01). Recipient site complications occurred in 30 patients (15 percent), with history of prior radiation therapy being the only factor associated with increased risk by multivariate analysis (odds ratio 2.5; 95 percent CI = 1.1 to 5.7). No factors predicted the development of donor-site complications, which occurred in 11 cases (5.5 percent). The median hospital stay for the entire population was 16 days. The development of complications increased the median hospital stay by 7.5 days (p < 0.001). The effect of the development of complication on hospital stay remained significant even after controlling for the effects of confounding variables (relative risk = 9.87; 95 percent CI = 5.9 to 19.9). Microvascular surgery is a highly successful and relatively safe method for the reconstruction of large head and neck defects. The Charlson comorbidity index grading may be useful for identifying patients at increased risk for the development of complications after microvascular reconstruction, allowing for improved perioperative planning. In addition, patients with prior radiation exposure have a significantly higher risk for developing complications at the recipient site. Although advanced age is not associated with an increased risk for complications, older patients may be more sensitive to the effects of prolonged anesthesia and are likely to develop more severe complications. PMID- 9950526 TI - Adult psychological functioning of individuals born with craniofacial anomalies. AB - This study represents an initial investigation into the adult psychological functioning of individuals born with craniofacial disfigurement. A total of 24 men and women born with a craniofacial anomaly completed paper and pencil measures of body image dissatisfaction, self-esteem, quality of life, and experiences of discrimination. An age- and gender-matched control group of 24 non facially disfigured adults also completed the measures. As expected, craniofacially disfigured adults reported greater dissatisfaction with their facial appearance than did the control group. Craniofacially disfigured adults also reported significantly lower levels of self-esteem and quality of life. Dissatisfaction with facial appearance, self-esteem, and quality of life were related to self-ratings of physical attractiveness. More than one-third of craniofacially disfigured adults (38 percent) reported experiences of discrimination in employment or social settings. Among disfigured adults, psychological functioning was not related to number of surgeries, although the degree of residual facial deformity was related to increased dissatisfaction with facial appearance and greater experiences of discrimination. Results suggest that adults who were born with craniofacial disfigurement, as compared with non facially disfigured adults, experience greater dissatisfaction with facial appearance and lower self-esteem and quality of life; however, these experiences do not seem to be universal. PMID- 9950527 TI - The fetal cleft palate: I. Characterization of a congenital model. AB - Any animal model of a human congenital anomaly established by iatrogenic methods involving intrauterine fetal manipulation has limited clinical applicability. A congenital model that more closely simulates the etiopathogenesis of a human anomaly may provide data that can more readily be extrapolated to that anomaly and, therefore, be used in diagnostic and management strategies. The present work provides a description and characterization of a congenital model of cleft palate in the goat. Palatal shelf closure normally occurs at approximately day 38 of gestation in the caprine species. Sixteen pregnant goats were gavaged twice daily during gestational days 32 through 41 [term, 145 days] with a plant slurry of Nicotiana glauca containing the piperidine alkaloid teratogen anabasine. Gross analysis and measurement of fetal clefts were performed at 60, 70, and 85 days gestation (four fetuses were studied at each time point). Seventeen clefted kids were sacrificed at specific intervals after birth (2 weeks, and 1, 3, and 6 months); after skull debridement and preparation, they were compared with 12 unclefted control kids. Complete clefting of the secondary palate occurred in 97 percent of the fetuses. In all cases, the cleft extended from the posterior aspect of the alveolar ridge to the uvula; the majority of these clefts were bilateral, with complete detachment of the vomer. Morphologically, these clefts were similar to human clefts. Eighteen percent of clefted newborn kids demonstrated gross maxillary hypoplasia and midfacial retrusion at birth with a relative Class III malocclusion. Direct measurement of the congenital caprine skulls confirmed these findings. The incidence of midfacial growth abnormalities in these clefted animals raises questions regarding the etiopathogenesis of facial dysmorphology that is unrelated to scarring of the maxilla. This congenital cleft palate model is currently being used to explore these questions and others related to craniofacial growth and palatal function after in utero repair. PMID- 9950528 TI - Advancement of the midface using distraction techniques. AB - Fourteen patients underwent Le Fort III midface advancement using distraction techniques. Six have cephalometric documentation extending beyond 1 year postoperatively, and the positions of cephalometric points A and orbitale over time are reported here. Excellent stability of advancement at the occlusal level and some relapse at the level of orbitale are documented. Elimination or diminution of obstructive sleep apnea occurred in all patients so affected, and one of two patients with tracheostomy has been decannulated. Speech effects have been mild or transient. No untoward effects on extraocular muscle function have occurred. PMID- 9950529 TI - Tongue reconstruction: outcomes with the rectus abdominis flap. AB - Advanced carcinoma of the oral cavity is a devastating disease, with the potential for severe speech and swallowing dysfunction. This is a retrospective review documenting the outcome of 14 patients who underwent resection of at least 75 percent of their tongue with preservation of the larynx and an intact mandible. Reconstruction was accomplished with rectus abdominis free tissue transfer. There were seven male and seven female patients between the ages of 25 and 77 years (mean, 55 years) who underwent total (eight patients) or subtotal (six patients) glossectomy and reconstruction. Decannulation of the tracheostomy tube was performed in 12 patients (86 percent) at an average of 3.5 months postoperatively. One patient required interval laryngectomy for intractable aspiration 1 month postoperatively. Independent evaluation of speech, articulation, and deglutition was performed. Fifty percent of patients achieved oral intake of pureed foods or better. Sixty-four percent had acceptable speech. Reconstruction with rectus abdominis free tissue transfer is a viable method for rehabilitation, improving quality of life after total or subtotal glossectomy with laryngeal preservation. PMID- 9950530 TI - Sensation recovery on innervated radial forearm flap for hemiglossectomy reconstruction by using different recipient nerves. AB - The objectives of this study were (1) to determine the extent of sensory recovery on hemitongues reconstructed with innervated radial forearm flaps and (2) to assess the influence of various clinical and surgical factors over the return of sensation, including the use of different recipient nerves for neurorrhaphy. Twenty-eight patients with tongue cancer who underwent hemiglossectomy and primary reconstruction with innervated radial forearm flaps over a 3-year period were studied. Mean postoperative follow-up was 18.2 months (range 6 to 32 months). Sensory recovery was assessed in a blind manner by two examiners that used (1) static two-point discrimination, (2) light touch sensation, (3) pain perception, and (4) hot and cold temperature perception. Different surfaces were assessed with each method on the reconstructed hemitongue and on the intact contralateral hemitongue (used as control). The following factors and their relationship with flap sensory recovery were analyzed: age, smoking history, size of the reconstructed defect, administration of postoperative radiation therapy, recipient nerve, and neurorrhaphy technique. Comparative statistical analysis (p < 0.05) between both hemitongues was performed using paired t test followed by Bonferroni correction for static two-point discrimination and light touch sensation. Fisher exact test analysis was used for pinprick and hot and cold temperature perception. The control side was ignored in analyzing the effects of the risk factors. The tip, dorsal aspect, ventral surface, and floor of mouth on the reconstructed hemitongue had comparable static two-point discrimination when compared with the intact hemitongue. Light touch sensation was also similar in the tip and dorsal aspect of both hemitongues; however, a statistically significant difference (p < 0.05) was observed on the ventral surface and floor of mouth of the reconstructed hemitongues. Likewise, pain perception was significantly decreased in the floor of the mouth, compared with other surfaces. No clearly dependent association was established between return of flap sensation and age, tobacco use, and size of the reconstructed defect. Light touch sensation, pain, and temperature perception were significantly decreased when the patients had received postoperative radiation therapy. In addition, all four sensory tests were significantly diminished (p < 0.05) when the recipient nerve used for neurorrhaphy was a nerve other than the lingual or the inferior alveolar nerve, and also when an end-to-side nerve repair was used. Sensation recovery of the innervated radial forearm flap after hemitongue reconstruction approaches normal compared with the contralateral intact hemitongue. Lower return of sensation may be anticipated in patients who receive postoperative radiotherapy. Good recovery of sensation is predictable when either the lingual or inferior alveolar nerve is used for neurorrhaphy, in contrast to using other recipient nerves. PMID- 9950531 TI - Prefabricated free jejunal transfer: a new reconstructive technique for high pharyngeal defects. AB - A new method that uses a prefabricated free jejunal transfer has been applied to three cancer patients with pharyngoesophageal defects with a high pharyngeal deficit extending up to the nasopharynx. In this method, the jejunum harvested in the usual manner is divided into two segments with a single vascular pedicle. Its distal segment is used to reconstruct the cervical esophagus, and its proximal segment is turned over to create a mucosal patch to cover the high pharyngeal defects. The two segments are then co-apted in a side-by-side anastomosis. The esophagus can be reconstructed in a naturally straight shape without a curved portion or blind loop formation, thus leading to good swallowing function. In our series, all grafts survived well and there was no complication directly related to jejunal transfer. All patients could tolerate a soft diet without difficulty. This method is easy to perform and applicable to any shape or size of very high pharyngeal defects that cannot be reconstructed properly by other methods. Although patients with an advanced hypopharyngeal cancer usually have a poor prognosis, this technique allows a better quality of life for a probable short life span. PMID- 9950533 TI - Free split and segmental latissimus dorsi muscle transfer in one stage for facial reanimation. AB - The authors report the experience in facial reanimation using free innervated split and segmental latissimus dorsi muscle flap one-stage transfer in 86 patients with longstanding facial palsy. The segmental latissimus dorsi was taken from the distal part of the muscle so that the muscle flap had an ultra-long neurovascular pedicle of 13 to 17.5 cm in length. The muscle flap was made thinner by splitting the segmental muscle. The split segmental muscle flap was transferred to the paralyzed side of the face with its ultra-long neurovascular pedicle passing through a tunnel in the upper lip to the normal side of the face. The neurovascular pedicle of the muscle flap was anastomosed with the facial nerve, artery, and veins, respectively, on the normal side of the face. The operation was designed without the cross-facial nerve graft stage. From 1986 to October of 1997, 86 patients with long-standing facial paralysis were treated in our department. The duration of facial palsy in this series ranged from 1.5 to 51 years. A satisfactory result was obtained in 80 cases, evaluated at 8 months to 2 years postoperatively. The expression movement of the soft tissues of the face can be seen not only over transferred muscle but also on the paralyzed muscle covered by the splitting muscle flap. It is supposed that this is the result of muscle-muscle neurolization. Study of 66 specimens of latissimus dorsi muscle in the cadavers is discussed. PMID- 9950532 TI - An ipsilateral superdrainaged transverse rectus abdominis myocutaneous flap for breast reconstruction. AB - A conventional single pedicled TRAM (transverse rectus abdominis myocutaneous) flap is a musculocutaneous flap widely used for breast reconstruction. However, complications such as partial flap necrosis, fat necrosis, and fatty induration may occur as a result of unstable blood flow circulation to the flap. One major factor is venous congestion in the flap. In an effort to obtain more stable TRAM flap blood circulation, we anastomosed the ipsilateral deep inferior epigastric vein of a pedicled TRAM flap to the thoracodorsal vein. This procedure provides superdrainage by means of enhanced venous perfusion. This flap with superdrainage augmentation is referred to as a superdrainaged TRAM flap (12 patients). Changes in cutaneous blood flow were also assessed by measurement of cutaneous blood flow in zone IV using a laser blood flow meter (8 patients). The patients who underwent breast reconstructive surgery using this technique showed no evidence of postoperative complications such as flap necrosis, fat necrosis, or fatty induration. Satisfactory results were obtained during breast reconstruction in patients who had previously undergone a radical mastectomy with resultant large areas of tissue defects. In addition, the two patient groups, 12 patients with superdrainaged TRAM flap and 20 patients with single pedicled TRAM flap, were compared to assess differences in complications. The incidence of partial flap necrosis, fat necrosis, and fatty induration was lower among patients with superdrainaged flap than those with single pedicled flap. PMID- 9950534 TI - Digital images in the diagnosis of wound healing problems. AB - The use of digital wound images could allow remote consultation among patients, physicians, or other care-givers located at quite distant sites by means of the Internet. To evaluate the efficacy and validity of digital images for the evaluation of wounds, the ability and reliability of surgeons to diagnose and make treatment suggestions using digital images of several types of wounds were compared. Twenty-four wound images on 35-mm slides were selected for use in this study. Each slide image was digitized at 24-bit color with a resolution of 640 pixels horizontal by 425 pixels vertical and stored as a JPEG file. These images were then presented as a slide show on a video monitor, with resolution set at 640 x 480. Six physicians examined the images, first in digital format and later in the original slide form. Each observer assessed each wound and possible treatment options by filling out a questionnaire using a series of yes/no questions. For all observers, there was an 87 percent agreement between digital and slide images (p = 0.004). The agreement between the digital and slide images was measured for each individual observer using a kappa coefficient. The agreement level corresponded to the experience of the observer, with the kappa values ranging from greater than 0.8 (almost perfect agreement) for the attending plastic surgeon to just greater than 0.5 (moderate agreement) for the intern. With this study, the feasibility of distance wound consultation using digital images of a quality consistent with consumer-grade digital photography was demonstrated. PMID- 9950535 TI - Surgical reconstruction of the contracted eye socket and orbitozygomatic hypoplasia in a one-stage operation. AB - To correct the contracted eye socket and orbitozygomatic hypoplasia simultaneously secondary to previous surgery and radiotherapy, we employed a one stage surgical reconstruction that used a postauricular skin flap and temporal fascial flap, which were rotated for eye socket reconstruction and bone graft coverage. Hydroxyapatite was inserted as an onlay bone graft substitute to enlarge the orbitozygomatic region. In our 12-case experience the results were satisfying and encouraging with minor complications, which are presented. PMID- 9950536 TI - Venous drainage of the distally based lesser saphenous-sural veno neuroadipofascial pedicled fasciocutaneous flap: a radiographic perfusion study. AB - The drainage pathway of the distally based lesser saphenous-sural veno neuroadipofascial pedicled fasciocutaneous flap using accompanying arteries of the lesser saphenous vein and sural nerve as nutrient vessels of the flap was radiographically investigated using five fresh cadavers. Small long veins existed along the lesser saphenous vein, and they were considered to be concomitant veins of the accompanying arteries of the lesser saphenous veins. They anastomosed with the lesser saphenous vein in some places and played a role in bypassing valves in the lesser saphenous vein. PMID- 9950537 TI - Toe transplantation for isolated index finger amputations distal to the proximal interphalangeal joint. AB - Functional deficit following single distal index finger amputations has been considered insignificant, and reconstruction is usually not recommended. Herein, 19 cases of second toe transplantation for reconstruction of isolated index finger amputation distal to the proximal interphalangeal joint are presented with long-term functional results. There are 14 men and 5 women. The average age was 26 years. The toe transplantations were performed either as a primary procedure (5 patients) while the wounds were still open or as a secondary procedure (14 patients) after the wounds healed. In 11 patients, the dominant hand was involved. All toes survived completely, although re-exploration was required in three cases (16 percent). The functional evaluation included (1) sensory recovery, where the average static and moving two-point discrimination were 8 mm (range 4 to 15 mm) and 6 mm (range 2 to 15 mm); (2) motor function, where the average of index-thumb pulp-to-pulp pinch compared with the normal hand was 67.5 percent (range 36 to 96 percent); (3) average range of motion in index finger joints (extension/flexion), where metacarpophalangeal joint was 14/90, proximal interphalangeal joint was 0/94, and distal interphalangeal joint was 19/38; and (4) functional and cosmetic results, where percentage of involvement in daily activities and functional capacity of the reconstructed index were 69 percent and 70.5 in average, respectively, over a total score of 100. Average scores of aesthetic appearance and acceptability of donor-site deformity were 74 and 87.5 over a total score of 100, respectively. Toe transplantation for distal index finger amputations improved hand function when performed in selected patients with specific job requirements or high motivation. PMID- 9950538 TI - Classification of the first web space free flap of the foot and its applications in reconstruction of the hand. AB - Owing to its unique anatomic arterial supply and dual nerve innervation, the first web space of the foot can be used to harvest various sizes and shapes of flaps, which the authors have classified into four types according to their usage in hand reconstruction. This in turn depends on the site, shape, and size of the soft-tissue defect in the hand. Web skin flaps (n = 8) were used in prevention of contracture in the first web space and for proximal finger reconstruction. Two island skin flaps (n = 4) were used to resurface the pulp defect in two adjacent fingers. In severe adduction contracture of the first web space, fill-up web flaps (n = 10) were used to replace the volume defect after a release procedure in the hand. Adjuvant web flaps (n = 9) were used in wrap-around procedures, in dorsalis pedis flap transfer, and in vascularized joint transfer to supplement the main flaps and to restore sensation in the reconstructed area. In the past 10 years up to February of 1998, a total of 31 patients with soft-tissue defects in the hand and fingers were reconstructed using the web space free flap with flap survival rate of 100 percent. The mean static 2-point discrimination was 8.5 (7.2 to 10) mm, and the mean first web angle was 86 degrees. The advantage of the first web space flap from the foot is that it can easily be harvested to match various sizes and shapes of defects in the hand and fingers. In addition, because of the anatomic similarity in contour, thickness, texture, and nerve innervation with the hand, the sensory restoration is excellent with minimal morbidity at the donor site. By classifying the flaps into four types according to various sizes, shapes, and the site from which the flap are harvested, clinical usefulness in various types of hand and finger reconstruction was confirmed. PMID- 9950539 TI - Laparoscopic rectosigmoid colpopoiesis: does it benefit our transsexual patients? AB - When inversion of the combined penile and scrotal skin flaps for vaginoplasty in male-to-female transsexuals has not led to functional results, rectosigmoid colpopoiesis offers an immediate solution to a complicated and difficult problem. However, open colocolpopoiesis involves major surgery, and it may be associated with substantial extended morbidity and hospitalization, short- and long-term unfavorable results, and extensive scarring of the abdomen. To reduce this associated morbidity, we employ a laparoscopically assisted approach and a total laparoscopic rectosigmoid colpopoiesis. This procedure has been performed safely in the series presented herein, with no apparent compromise in the adequacy of the dissections. We conclude that our patients benefited from this procedure, and we advocate considering a total or partial laparoscopic approach whenever secondary rectosigmoid colpopoiesis is indicated in male-to-female transsexuals. PMID- 9950540 TI - The use of eccentric circummeatal-based flap with combined limited urethral mobilization technique for distal hypospadias repair. AB - We report a suitable approach to the correction of subcoronal meatus for any variants and report our experience with this method. An eccentric circummeatal based flap was used to treat 42 patients with hypospadias during a 4-year period. The position of the meatus was coronal in 18 patients (43 percent) and subcoronal and distal penile in 16 (38 percent) and 8 (19 percent) patients, respectively. In addition, 19 patients had marked ventriflexion. The mean length of the urethroplasty was 1.1 cm (ranging from 0.6 to 1.7 cm). In no instance was residual ventral curvature noted nor did the neourethra restrict the phallus during erection. The functional and cosmetic results were excellent, and in many cases the glans penis assumed a nearly normal shape and appearance. No patient required a second procedure to improve cosmesis. This is a convenient procedure for correction of distal hypospadias in which the urethral gap is no longer than 2 to 2.5 cm. The surgical repair does not depend on glanular or meatal variations or even if the patient had a previous operation. It is particularly suitable in cases that have marked fibrous chordee. PMID- 9950541 TI - Transdermal photopolymerized adhesive for seroma prevention. AB - The purpose of this study was to determine whether or not a synthetic photopolymerized tissue adhesive (polyethylene oxide hydrogel) is useful in seroma prevention using a well established rat mastectomy seroma model. Twenty three Sprague-Dawley rats received mastectomies. The rats were randomly assigned to either the control group (n = 13) or the experimental group (n = 10). The control animals received 0.2 cc of saline into the wound before closure. The experimental group received either 0.2 cc (n = 5) or 0.4 cc (n = 5) of the polyethylene oxide polymer into their wounds before closure. The experimental animals were placed under an ultraviolet A lamp for 3 minutes to polymerize the adhesive. On postoperative day seven, the resultant seromas were quantified, and wound tissues were harvested for histologic evaluation. The rats in the control group had a mean seroma volume of 3.25 cc (SD = 2.41), whereas the rats treated with polymer had a mean seroma volume of 0.37 cc (SD = 0.51). A Student's t test was performed showing a statistically significant difference between the control and experimental groups (p < 0.005). The volume of polymer used (0.2 cc versus 0.4 cc) did not significantly impact the volume of the resultant seromas. This study demonstrates that photopolymerizable polyethylene oxide hydrogels can be used as a tissue adhesive and that such an adhesive significantly reduces seroma formation in the rat mastectomy model. PMID- 9950542 TI - Rat mandibular distraction osteogenesis: II. Molecular analysis of transforming growth factor beta-1 and osteocalcin gene expression. AB - Distraction osteogenesis is a powerful technique capable of generating viable osseous tissue by the gradual separation of osteotomized bone edges. Although the histologic and ultrastructural changes associated with this process have been extensively delineated, the molecular events governing these changes remain essentially unknown. We have devised a rat model of mandibular distraction osteogenesis that facilitates molecular analysis of this process. Such information has significant clinical implications because it may enable targeted therapeutic manipulations designed to accelerate osseous regeneration. In this study, we have evaluated the expression of transforming growth factor beta-1, a major regulator of osteogenesis during endochondral bone formation and development, and osteocalcin, an abundant noncollagenous extracellular matrix protein implicated in the regulation of mineralization and bone turnover. The right hemimandible of 36 adult male rats was osteotomized, and a customized distraction device was applied. Animals were allowed to recover and, after a 3 day latency period, were distracted at a rate of 0.25 mm twice daily for 6 days followed by a 2- or 4-week consolidation period. Distraction regenerate was harvested after the latency period, days 2, 4, or 6 of distraction, and after 2 or 4 weeks of consolidation and processed for Northern analysis (n = 4 at each time point) and immunohistochemical localization of TGF-beta1 (n = 2 at each time point). Six sham-operated animals (i.e., skin incision without osteotomy) were also killed (immediately postoperatively), and the mandibles were harvested and prepared in a similar fashion. Equal loading and transfer of RNA for Northern analysis was ensured by stripping and probing membranes with a probe against GAPDH (a housekeeping gene). Our results demonstrate that the spatial and temporal patterns of TGF-beta1 mRNA expression and protein production coincide with osteoblast migration, differentiation, and extracellular matrix synthesis. In addition, we demonstrate that TGF-beta1 production may be an important regulator of vasculogenesis during mandibular distraction osteogenesis. Finally, we have shown that osteocalcin gene expression coincides temporally with mineralization during rat mandibular distraction osteogenesis. PMID- 9950544 TI - Primary amyloidosis presenting as extensor tenosynovitis. AB - Primary amyloidosis is a systemic disease. Amyloid arthropathy is an invalidating and uncommon form of presentation, but tenosynovitis is even rarer as the first sign of the disease. We report herein a case of unilateral amyloid deposit in the synovium of the extensor tendons of the hand, which was the first manifestation of a primary amyloidosis. PMID- 9950543 TI - Prophylactic mastectomy, oophorectomy, hysterectomy, and immediate transverse rectus abdominis muscle flap breast reconstruction in a BRCA-2-positive patient. PMID- 9950545 TI - Recognition, diagnosis, and management of heparin-induced thrombocytopenia and thrombosis. AB - This case report describes a post-coronary artery bypass graft patient who developed arterial thrombosis and loss of a dominant hand as a result of the common and serious immune complication of heparin anticoagulation, heparin induced thrombocytopenia and thrombosis. This report underscores the need for all surgeons who use heparin in the course of their practice to be aware of heparin induced thrombocytopenia and the spectrum of its clinical presentations and management. Thrombocytopenia or thrombosis that occurs in a patient receiving heparin should prompt a surgeon to stop all heparin as soon as possible and seek appropriate hematologic consultation. Because heparin-induced thrombocytopenia and heparin-induced thrombocytopenia and thrombosis are mainly clinical diagnoses, one should not wait for objective test confirmation of heparin-induced thrombocytopenia before stopping all heparin treatment. Alternative anticoagulation, other than low molecular weight heparin, must be considered for the patient who develops either condition. For surgeons who perform hand surgery, it is necessary to be aware of the significance of upper extremity thrombosis in a patient who is receiving heparin when consulted for surgical management. PMID- 9950546 TI - A novel surgical method of repair for Stahl's ear: a case report and review of current treatment modalities. AB - Stahl's ear is a congenital malformation of the auricle, which is uncommon in non Oriental societies. A number of different treatment modalities have been suggested, many of which yield unpredictable results. We review current treatment modalities from the English literature and describe a novel, simple surgical method of repair. First, a helical rim incision is made to expose the abnormal third crus and upper pole of the ear. The third crus is excised as a narrow wedge of cartilage and posterior skin, and the defect is closed primarily. The free third crus cartilage is then grafted onto the scaphal cartilage in an anatomically correct position to form a superior crus. The anterior skin flap is redraped and bolstered over this graft. Only a very small scar on the helical rim remains visible anteriorly. PMID- 9950547 TI - Microvascular great toenail transfer after conventional thumb reconstruction. PMID- 9950549 TI - The use of micrografts and minigrafts for the treatment of burn alopecia. PMID- 9950550 TI - Completing the cosmetic surgery cycle: it takes a village. PMID- 9950548 TI - Lateral calcaneal V-Y advancement flap for repair of posterior heel defects. AB - We obtained favorable results in reconstruction of the posterior heel with a lateral calcaneal V-Y advancement flap. This technique simplifies the operative procedure and eliminates the disadvantages of the original lateral calcaneal flap and its island version while retaining the advantages of these methods. PMID- 9950551 TI - CO2 and erbium:YAG laser resurfacing: current status and personal perspective. PMID- 9950552 TI - Long-term assessment of CO2 facial laser resurfacing: aesthetic results and complications. AB - Several series have documented the ability of the carbon dioxide laser to smooth facial rhytids; however, follow-up has been limited to several months. Since 1995, more than 600 full or partial facial resurfacings were performed with the pulsed CO2 laser. To assess the long-term efficacy and safety of this procedure, the results of 211 resurfacings were retrospectively reviewed using a custom designed database. Variables that were input included patient demographics, Fitzpatrick skin type, smoking history, prior and concurrent facial procedures, laser pass data, and postoperative complications. Short and long-term aesthetic results were graded by a blinded panel of plastic surgery reviewers (none of whom performed the laser resurfacing) using a standardized photographic rhytid scale. For each facial region, this scale consisted of eight high-resolution photographs depicting increasingly severe wrinkling. Facial rhytids were almost completely ablated at the 3 and 6 month follow-up. Some relapse was seen at 1 year, but the overall aesthetic result remained very good. Regions with dynamic rhytids (e.g., the perioral region) showed more recurrence. The best and most durable results were seen in the cheeks. Infection and scleral show each occurred in 13 patients (6 percent). Forty-five patients (21 percent) developed postprocedure hyperpigmentation, but the overwhelming majority of this group were treated before our postoperative antipigment regimen. Hypopigmentation was noted in 17 patients (8 percent) in this early follow-up group. Two patients (1 percent) developed postoperative scarring. It is hoped that these data will serve to provide additional information on the long-term results of laserbrasion. PMID- 9950553 TI - Erbium laser resurfacing: current concepts. AB - Laser skin resurfacing has enjoyed great popularity in recent years with the introduction of computerized, pulsed carbon dioxide lasers. However, the morbidity and side effects of carbon dioxide lasers have stimulated a search for alternative methods of skin remodeling. The erbium:YAG laser can be successfully used for skin resurfacing, with lower morbidity than the carbon dioxide laser. In a series of 625 patients who had erbium:YAG resurfacing, the following conclusions were reached. (1) Long-term (> 6 months) improvement in wrinkles and acne scars required total fluences exceeding 20 J/cm2. Periocular wrinkles required total fluences of between 20 and 40 J/cm2, depending on the depth of the wrinkles and skin thickness. Perioral rhytids required total fluences of between 40 and 80 J/cm2, whereas the cheeks and forehead required total fluences of 30 to 60 J/cm2. (2) Deeper wrinkles were best treated with a combination of erbium and carbon dioxide lasers, which minimized the bleeding that occurs with deeper erbium resurfacing. The simultaneous combined erbium with carbon dioxide laser was particularly advantageous. (3) Complications were relatively uncommon using the scanning erbium laser, and most adverse effects occurred early in the series. Scarring occurred in 5 of the 625 patients (0.8 percent) and mostly resolved with intralesional steroids. Hyperpigmentation occurred in 21 of the 625 patients (3.4 percent) and was temporary in nature. Hypopigmentation, which became evident after 6 months, occurred in 25 of the 625 patients (4.0 percent) but was mild and not a significant cosmetic problem, except in one patient who developed scarring on the neck. Hypopigmentation seemed to be related to the depth of resurfacing. Four of the 625 patients (0.6 percent) developed temporary scleral show, but no patients had permanent ectropion. Eight of the 625 (1.3 percent) developed synechiae under the lower eyelid, which required minor correction. PMID- 9950554 TI - Cutaneous resurfacing with CO2 and erbium: YAG lasers: preoperative, intraoperative, and postoperative considerations. AB - The development and integration of pulsed and scanned CO2 and erbium:YAG laser systems into mainstream surgical practice over the past years has revolutionized cutaneous resurfacing. These lasers are capable of delivering to skin high peak fluences to effect controlled tissue vaporization, while leaving an acceptably narrow zone of residual thermal damage. The inherent technological differences that exist between the two distant laser systems in terms of ablation depths, degree of thermal coagulation, and postoperative side-effects and complications guide patient selection and management. This article reviews the basic principles of CO2 and erbium:YAG laser resurfacing, including preoperative, intraoperative, and postoperative patient considerations. Side-effects and complications encountered after laser resurfacing are discussed with specific guidelines provided on their appropriate management. Anticipated future developments and cutting-edge research endeavors in cutaneous laser resurfacing are also briefly outlined. PMID- 9950555 TI - Concertina effect and facial aging: nonlinear aspects of youthfulness and skeletal remodeling, and why, perhaps, infants have jowls. AB - The effect of aging on the orbitomaxillary region is evaluated in the present study. The observation was made that infants look like aged individuals in terms of the midface soft-tissue contours of the midface. Because preliminary work has shown that the facial skeleton remodels throughout life, this observation led to the hypothesis that infants and older individuals appear similar because they have comparable skeletal dimensions, specifically in the orbitomaxillary region. The design is a retrospective analysis of three-dimensional computed tomographic scan data. Three groups of male subjects were studied: infant, ages 1 to 12 months (n = 5); youthful, ages 15 to 24 years (n = 13); and old, ages 53 to 76 years (n = 12). Orbital and zygomaticomaxillary vertical dimensions were measured in both medial and lateral planes between fixed anatomical landmarks. Results were compared by using analysis of variance, Student-Newman-Keuls, and Student's t tests. The findings show that skeletal remodeling is such that the ratio of the maxillary height to orbital height is greatest during youth; during infancy and old age, there is a short maxilla relative to a larger orbit. This finding is significant in the medial plane from orbital rim to pyriform aperture (p < 0.05). Furthermore, there is an actual decrease in vertical maxillary height in this medial plane (p < 0.01) from youth until old age, which occurs secondary to normal skeletal remodeling in the dentate individual. The combined effect of downward expansion of the orbital shelf and the upward migration of the pyriform effectively decreases the space available to support the overlying soft tissues of the midface. An accordion-like or "concertina" effect may lead to compression or restriction of the facial soft tissues over a relatively deficient bony platform. These results highlight the importance of skeletal remodeling in determining the soft-tissue contours of the aging face. The process of skeletal remodeling may also allow for a tentative definition of facial youthfulness. Infants are born with a short maxilla relative to a large orbit, and the maxillary wall is angled posteriorly. This ratio and angle change from infancy until youth, when there is a balance between the bony skeletal support and the overlying soft-tissue envelope, i.e., the skin, facial muscles, and adipose tissue. It is when skeletal remodeling continues past this point that a disharmony occurs. Because the ratio of maxilla/orbit, and the angle of the maxillary wall, in the older person reverts toward that of an infant, the attainment of youth occurs partly in a nonlinear or multimodal manner. This work is part of an emerging concept of facial aging, which we would term an integrated model of facial aging. This model allows facial aging to be viewed as a biological "system," in which there are primary and secondary factors that interact in the process of facial aging. Additional research such as this continues to suggest the importance of bony remodeling in facial aging. PMID- 9950556 TI - Botulinum A exotoxin for the management of platysma bands. AB - Injections of botulinum A exotoxin are successfully used to treat neuromuscular disorders and to improve hyperkinetic muscles and dynamic rhytids of the upper face. Using these principles, we extended its use to the treatment of the aging neck (hypertrophic platysma muscle bands). A classification system (I to IV) based on horizontal neck rhytids, platysma bands, and skin laxity was devised to categorize the degree of deformity and serve as a guideline for suggested dosages of botulinum. The results correlated with the degree of age-related neck degeneration. Type II (mild horizontal neck rhytids; thin, mild platysma muscle flaccidity; and mild skin laxity) and III (moderate horizontal neck rhytids; thick, moderate platysma muscle flaccidity; and moderate skin laxity) patients were the most satisfied, followed closely by types I and IV. A total of 1500 patients were treated by three independent practices. The majority of them achieved good-to-excellent results, as evaluated by both the physician and patient. The degree of muscle flaccidity and hypertrophy were the factors that most influenced success rates, not the anatomic variations in muscle configuration. PMID- 9950557 TI - Nonsurgical treatment of platysmal bands with injection of botulinum toxin A. AB - Botulinum toxin A has been used therapeutically in humans for over 20 years for a variety of medical indications. For the past 7 years, the author has injected it for cosmetic purposes in a variety of muscles of the head and neck. Fifty patient injections of the platysma muscle were performed in an attempt to correct platysmal banding. An improvement was seen in all patients who presented to the office for follow-up in a timely manner (44 injections). Results were limited by redundant skin. No incidence of dysphagia or airway obstruction was encountered. The only complication noted was bruising. Although at least a small improvement in platysmal banding was seen in all patients, in no patient was there evidence of lifting of the lower face. All results were temporary. PMID- 9950558 TI - The antibacterial effects of tumescent liposuction fluid. AB - Tumescent liposuction is currently one of the most commonly performed aesthetic procedures. Despite the variable use of preoperative antibiotics, infection is uncommon. Prior works suggest that the low incidence of infection may be due to lidocaine's antibacterial properties. However, these properties have only been demonstrated using concentrations of lidocaine above 0.8%, significantly higher than those used in tumescent liposuction. The purpose of this study was to determine if the commonly used tumescent fluid containing 0.1% lidocaine, 1:1000,000 epinephrine, and 0.012 mEq sodium bicarbonate possesses antibacterial activity. Using the broth microdilution method, the minimum inhibitory concentrations of Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus, and Group A beta-hemolytic Streptococcus were determined after exposure to either lidocaine, epinephrine, bicarbonate, or the combination of all three agents. To determine if there were significant growth differences not detectable by the broth microdilution method, bacterial concentrations were obtained through the use of a spectrophotometer, and significant differences from the controls were calculated by one-way analysis of variance. To determine if prolonged exposure to the tumescent mix would alter bacterial growth, a Killing Time study was also undertaken. The results indicated that the minimum inhibitory concentration of lidocaine was not less than 0.5% for any of the bacteria, whereas the lowest minimum inhibitory concentration of the combined solution was 0.25%. The lowest inhibitory concentration as determined by spectrophotometric analysis for the combined solution was 0.13% (p < 0.01). Analysis of the Killing Time data revealed no inhibition of bacterial growth over time. In conclusion, lidocaine, epinephrine, and bicarbonate do exhibit antibacterial properties at high concentrations. However, the commonly used tumescent mixture containing dilute concentrations of these agents does not significantly inhibit the growth of commonly encountered bacteria. PMID- 9950559 TI - Aesthetic rhinoplasty with maximum preservation of alar cartilages: experience with 52 consecutive cases. AB - Historically, rhinoplasty has been conceptualized mainly as an excisional and reductional operation of the nasal framework; however, there is growing evidence showing that conservatism in terms of preserving as much skeleton as possible makes the final results more predictable and more physiologic. On the basis of this point of view and using modifications of Tebbetts' technique, a prospective study of 52 patients presenting for primary open rhinoplasty was made. In all the cases, the cephalic portion of the lateral crus was preserved, and the procedure was designed basically to create a better anatomy from an aesthetic point of view. The results were evaluated aesthetically and by cephalometry, and patients showed improvement; native crura preservation was maximized. This report suggests more prospective studies need to be conducted to demonstrate the efficacy of these surgical variations on the average patient. PMID- 9950560 TI - Pyriform augmentation as an ancillary procedure in facial rejuvenation surgery. AB - A patient is presented in whom augmentation of the pyriform aperture of the maxilla was performed with porous hydroxyapatite in concert with a face and brow lift. Basic research has recently shown that remodeling of the facial skeleton continues throughout life and that this remodeling process leads to changes in the position of several key areas. The pyriform aperture was identified as one region that remodels in a posterior direction, leading to retrusion of the alar base in the older individual. This skeletal retrusion occurs in a very site specific fashion, and its effects are reflected on the overlying soft tissues of the face. With aging, remodeling of the pyriform aperture posteriorly causes the alar base to appear recessed and decreases the nasolabial angle, changes that are noted on the profile of the older individual. Augmentation of the pyriform aperture can be achieved through a buccal sulcus incision and, when used in conjunction with standard facial rejuvenation procedures, can improve the overall result in facial cosmetic surgery. PMID- 9950561 TI - The anatomy of the nasolabial fold: the keystone of the smiling mechanism. PMID- 9950562 TI - Pricing strategy for aesthetic surgery: economic analysis of a resident clinic's change in fees. AB - The laws of microeconomics explain how prices affect consumer purchasing decisions and thus overall revenues and profits. These principles can easily be applied to the behavior aesthetic plastic surgery patients. The UCLA Division of Plastic Surgery resident aesthetics clinic recently offered a radical price change for its services. The effects of this change on demand for services and revenue were tracked. Economic analysis was applied to see if this price change resulted in the maximization of total revenues, or if additional price changes could further optimize them. Economic analysis of pricing involves several steps. The first step is to assess demand. The number of procedures performed by a given practice at different price levels can be plotted to create a demand curve. From this curve, price sensitivities of consumers can be calculated (price elasticity of demand). This information can then be used to determine the pricing level that creates demand for the exact number of procedures that yield optimal revenues. In economic parlance, revenues are maximized by pricing services such that elasticity is equal to 1 (the point of unit elasticity). At the UCLA resident clinic, average total fees per procedure were reduced by 40 percent. This resulted in a 250-percent increase in procedures performed for representative 4 month periods before and after the price change. Net revenues increased by 52 percent. Economic analysis showed that the price elasticity of demand before the price change was 6.2. After the price change it was 1. We conclude that the magnitude of the price change resulted in a fee schedule that yielded the highest possible revenues from the resident clinic. These results show that changes in price do affect total revenue and that the nature of these effects can be understood, predicted, and maximized using the tools of microeconomics. PMID- 9950563 TI - Botox for the treatment of dynamic and hyperkinetic facial lines and furrows: adjunctive use in facial aesthetic surgery. AB - Our improved understanding of the pathophysiology of facial lines, wrinkles, and furrows has broadened the treatment options for a variety of facial cosmetic blemishes. The persistence or recurrence of certain facial rhytids after surgery has confirmed the lack of full comprehension of their origin. Glabellar forehead furrows (frown lines) and lateral canthal rhytids (crow's feet) have been the most popular facial lines that have been shown to be mostly the result of regional hyperkinetic muscles, and their eradication may be more suitable, at times, to chemodenervation than to soft-tissue fillers, skin resurfacing, or surgical resection. Aesthetic surgical procedures that have yielded suboptimal results may also occur from failure to recognize other causative factors including hyperkinetic or dynamic musculature, which may contribute to etiology of the visible soft-tissue changes and lack of persistent effect after surgery. Chemodenervation with botulinum toxin A (Botox) has proven to be useful both as a primary treatment for certain facial rhytids and as an adjunctive agent for a variety of facial aesthetic procedures to obtain optimal results. PMID- 9950564 TI - Endoscopically assisted reconstruction of orbital medial wall fractures. AB - Traditional surgical approaches to orbital medial wall fractures are either direct extraocular skin incisions or indirect bicoronal flap. However, these methods can leave remarkable orbital scars or scalp alopecia with the possible associated complications. A minimally invasive endoscopic technique with the assistance of a 2.7-mm, 30-degree telescope through a medial transconjunctival incision has been successfully used to reconstruct the orbital medial wall fractures. This technique was applied to four patients who had orbital medial wall fractures. Three patients also had concomitant orbital floor fractures. The other had associated superior orbital fissure syndrome. All patients were presented with limited eye movement, positive forced duction test, horizontal diplopia, and enophthalmos (3 mm to 6 mm) preoperatively. The entrapped periorbital tissues in the ethmoid sinus were completely reduced endoscopically. The bone defect of orbital medial wall was reconstructed with autogenous rib bone grafts under endoscopic control. The patients were followed up for 8 to 16 months with an average of 11 months. Three patients recovered completely without any residual eye symptoms after intervention. Clinically significant residual enophthalmos of 3 mm occurred in the patient with the superior orbital fissure syndrome. His eye movement limitation caused by entrapment of medial rectus muscle was relieved postoperatively. There was no donor-site morbidity or any complications related to the endoscopically assisted procedure. Endoscopically assisted medial transconjunctival approach to the orbital medial wall fractures is an excellent adjunct for the exposure and complete reduction of herniated periorbital tissue and bony reconstruction of the medial orbital wall. PMID- 9950565 TI - Another 10 caveats. PMID- 9950566 TI - The best of intentions. PMID- 9950567 TI - So you're a plastic surgeon. PMID- 9950568 TI - Body contouring with external ultrasound. Plastic Surgery Educational Foundation DATA Committee. Device and Technique Assessment. PMID- 9950569 TI - Skin closures using cyanoacrylate tissue adhesives. Plastic Surgery Educational Foundation DATA Committee. Device and Technique Assessment. AB - Studies have been done and approval is soon possible from the FDA for an octylcyanoacrylate tissue glue for closure of lacerations of incisions. This is a newer-generation cyanoacrylate that improves on the butylcyanoacrylates currently in use in Canada and other countries but not approved by the FDA. It is a pliable, waterproof, film adhesive that can be applied to a laceration and left in place until it disintegrates in 7 to 14 days. It is safe and effective and represents an improvement over the butylcyanoacrylates that have been used for years in many countries. It is not a replacement for sutures but does offer an alternative. Some indications that seem appropriate are for closure of incisions that would be under casts; for simple lacerations in children to avoid the fear of suturing and suture removal; and for closure of incisions or lacerations where it would be a problem for a follow-up visit. This adhesive is less indicated for closure over highly mobile areas such as joints; for areas with usage and friction such as hands or feet; or for areas where exact alignment is a priority, such as the face or eyelids. PMID- 9950570 TI - Hairline incisions. PMID- 9950572 TI - Preserving the orbital fat in lower eyelidplasty. PMID- 9950571 TI - Axial pattern bilobed flap for the reconstruction of the midline forehead defects. PMID- 9950573 TI - Traumatic earlobe cleft repair by using a Desmarres clamp. PMID- 9950574 TI - Utility of Satinsky-type vascular clamps in end-to-side anastomoses in head and neck free tissue transfers. PMID- 9950575 TI - A technique for placement of cross-facial nerve grafts. PMID- 9950576 TI - A new nerve grafting technique: the multigraft unit. PMID- 9950577 TI - Dynamic technique: three-flap SMAS. PMID- 9950578 TI - An alternative treatment for Frey syndrome. PMID- 9950579 TI - The use of the rectus abdominis muscle and a vicryl mesh to protect the small intestine and the rectus in radiation treatments to the lower pelvis. PMID- 9950580 TI - Syringe splinting for skin grafts in penile reconstruction. PMID- 9950581 TI - A simple sign for the differential diagnosis of the congenital trigger thumb. PMID- 9950582 TI - Radioimmunoguided surgery in squamous cell carcinoma. PMID- 9950583 TI - An experimental application of gene therapy for human retinoblastoma. AB - PURPOSE: The purpose was to determine the potential of gene therapy for retinoblastoma using transfer of the herpes simplex virus thymidine kinase (HSV TK) gene into retinoblastoma cells (Y79 cell line). METHODS: A retrovirus packaging cell line PA317 was electroporated with a retroviral vector plasmid bearing HSV-TK and neomycin-resistance genes to produce a PA317-TK cell line releasing a replication-defective vector bearing both genes. Y79 was transduced by exposure to transmissible virus-containing medium from PA317-TK, and new clones of Y79 containing the HSV-TK gene (Y79-TK) were established. Sensitivity to ganciclovir (GCV) and acyclovir (ACV) was investigated in Y79 and Y79-TK and the effect of HSV-TK-positive cells on negative cells ("bystander effect") was determined in vitro. The effect of antitumorigenesis in a nude mouse system was also investigated. RESULTS: There were no differences in the growth pattern or the morphology between Y79 and Y79-TK. Y79-TK was more sensitive to GCV and ACV than was Y79. The cytotoxicity of Y79-TK was dose dependent. An obvious "bystander effect" was present with the addition of GCV. In vivo studies confirmed the ability of GCV to kill Y79-TK. CONCLUSIONS: In this study a model is proposed for the introduction of a drug-sensitivity gene into Y79 and the possibility is raised of treating retinoblastoma with gene therapy. The results suggest that the transfer of the HSV-TK gene into Y79 followed by the administration of GCV could serve as a model for gene therapy for retinoblastoma. PMID- 9950584 TI - Adenovirally expressed basic fibroblast growth factor rescues photoreceptor cells in RCS rats. AB - PURPOSE: To evaluate the abilities of recombinant adenovirus carrying the basic fibroblast growth factor (bFGF) gene to (1) produce bFGF protein in vitro and (2) rescue retinal photoreceptors in Royal College of Surgeons (RCS) rats in vivo. METHODS: Cultured human retinal pigment epithelial cells were infected with one of the following two replication-deficient adenoviral vectors that drive inserted genes by beta-actin promoter with cytomegalovirus enhancer: AxCAJSbFGF, which expresses the human bFGF gene, and AxCAlacZ, carrying the cDNA of bacterial beta galactosidase as a viral control. These viruses and recombinant bFGF protein were also injected into the subretinal space of RCS rats at the age of 21 days. The production of bFGF was evaluated by an immunohistochemical method in vitro and in vivo. The secretion of bFGF produced in vitro was quantified by an enzyme-linked immunosorbent assay. The thickness of the outer nuclear layer (ONL) as a marker of photoreceptor cell rescue was estimated at 2, 28, and 56 days after the injections. RESULTS: AxCAJSbFGF produced human bFGF protein effectively both in vitro and in vivo. The semiquantitative analysis of ONL thickness revealed a significant protective effect of AxCAJSbFGF and the recombinant bFGF protein injection up to 56 days after injection. CONCLUSIONS: These results demonstrate that a recombinant adenoviral vector can achieve the transfer of bFGF gene in vitro and have a protective effect for photoreceptor cells in vivo. Gene therapy with a bFGF-expressing recombinant adenoviral vector may provide a new strategy with which to target retinal degenerative diseases. PMID- 9950585 TI - Self-reported assessment of visual function in a population-based study: the SEE project. Salisbury Eye Evaluation. AB - PURPOSE: To report on the usefulness of the Activities of Daily Vision Scale (ADVS) questionnaire for assessing visual functioning, a population-based sample of elderly Americans. METHODS: The ADVS questionnaire was administered to a population-based sample of 2520 community-dwelling individuals 65 to 84 years of age in Salisbury, MD. Items and subscales were evaluated for internal consistency, item discrimination, and content validity. Published subscale groupings and item associations in our population were compared for coherence using correlation, factor, and cluster analyses. Whole-sample and race- and gender-specific analyses were conducted. External validity was explored by regressing ADVS scores on standard psychophysical vision measures. RESULTS: ADVS scores were skewed to high visual functioning levels; approximately 60% of the population had function scores of 95 or better (of a possible 100). The overall, night driving, and near vision scales were internally consistent and had strong item-subscale associations; the day driving and glare subscales were not acceptable regarding these properties. The far vision subscale was acceptably scalable but only weakly differentiated from the other subscales. Overall, night driving, near vision, and far vision scores were all statistically and independently associated with multiple psychophysical vision measures. Findings were consistent across race and gender subgroups. CONCLUSIONS: As assessed by the ADVS, reported visual functioning is high in our representative older population. The overall scale and selected subscales effectively distinguish persons along a spectrum of ability. They correlate with measures of visual impairment in a reasonable way and thus hold promise for risk factor investigations. The published day driving and glare subscales should be examined for relevance and consistency before being applied in population-based settings. Methods specific to population-based settings should be investigated for their ability to better elicit additional visual function dimensions and early visual disability. PMID- 9950586 TI - Intracellular interaction of Hsp47 and type I collagen in corneal endothelial cells. AB - PURPOSE: Previous studies by the current investigators showed that type I collagen was posttranslationally regulated in corneal endothelial cells (CECs). These cells synthesize type I procollagen and degrade it intracellularly; however, when CECs are modulated with fibroblast growth factor-2 and/or corneal endothelium modulation factor, they synthesize and secrete type I collagen. Heat shock protein 47 (Hsp47), an endoplasmic reticulum resident protein, is known to function as a molecular chaperon in regulating procollagen folding and/or assembly. The interaction of Hsp47 with type I procollagen synthesis in CECs was also studied. METHODS: Expression of proteins was analyzed by radioactive labeling or immunoblot analysis. The steady state level of type I collagen and Hsp47 mRNAs was determined by northern blot analysis. Coprecipitation using immunoprecipitation followed by immunoblotting was performed to determine the association profile between Hsp47 and type I procollagen. Subcellular localization of Hsp47 and type I procollagen was determined by immunofluorescent staining. RESULTS: Normal and modulated cells expressed Hsp47 and Hsp70. The relative amount of Hsp47 produced by modulated cells was much higher than that of control cells, but the expression level of Hsp70 was the same in control and modulated cells. The steady state levels of type I collagen transcripts were higher in normal cells than in modulated cells, whereas modulated cells contained a much higher steady state level of Hsp47 mRNA. Type I procollagen was found to be associated with Hsp47 when analyzed by coprecipitation or cross-linking. The cytoplasmic localization profile of Hsp47 and type I collagen was different in normal cells, although a colocalization profile was observed to some degree. These two proteins were predominantly colocalized in the Golgi area in modulated CECs. CONCLUSIONS: Hsp47 may be involved in the synthesis and/or intracellular transport of type I collagen in CECs. Modulated cells that secrete type I collagen into the extracellular matrix express a higher level of Hsp47 than do control cells. PMID- 9950588 TI - In vivo human corneal hydration control dynamics: a new model. AB - PURPOSE: To introduce a new model describing human in vivo corneal deswelling after hypoxic contact lens wear, based on a damped harmonic oscillator, which can describe an overshoot in corneal deswelling, to compare this new model with the currently used exponential model, and also to test whether a diurnal variation in baseline corneal thickness exists that would have to be taken into consideration when calculating corneal deswelling curves. METHODS: In nine healthy young adults, corneal thickness was measured every 30 minutes for 11.5 hours on average using modified optical pachometry (natural test). On another day, corneal deswelling was monitored for 11.1 hours on average after 2 hours of hypoxic contact lens wear (stress test). The damped harmonic oscillator model and the exponential model were used to calculate best-fitting deswelling curves. Natural test data were analyzed for the presence of a trend. Goodness of fit of the curves to the experimental data was analyzed using the F test. RESULTS: In 82% of the deswelling curves the new damped harmonic oscillator model provided a better fit to the data than the exponential model (P < 0.05). An average overshoot in corneal thickness recovery of 5 microm (range, 0-11 microm) was found. In 50% of the natural tests significant trends were found, without any consistent similarities. The overshoot could not be explained by these trends. CONCLUSIONS: The new damped harmonic oscillator model describes corneal deswelling after hypoxic contact lens wear more accurately than the exponential model. No consistent diurnal variation could be demonstrated. PMID- 9950587 TI - Bone morphogenetic proteins and growth and differentiation factors in the human cornea. AB - PURPOSE: To investigate transcription of members of the transforming growth factor (TGF)-beta superfamily and corresponding receptors in human corneal epithelium and stroma. METHODS: Transcription of bone morphogenetic proteins (BMP)-2, BMP-3, BMP-4, BMP-5, and BMP-7; growth- differentiation factor (GDF)-5), and BMP receptors (BMPR) types I (BMPR-IA, BMPR-IB) and II (BMPR-II) was investigated by reverse transcription-polymerase chain reaction (RT-PCR) in ex vivo and cultured cells. For verification, PCR fragments were cloned and sequenced. DNA dot blot analysis was performed to estimate the level of transcription. RNA dot blots were performed to determine expression of GDF-5. Expression of BMP receptor proteins was investigated by immunohistochemistry. Single-cell clonal growth proliferation assays were performed using recombinant human GDF-5 and TGF-beta1. RESULTS: Transcription of BMP-2, BMP-3, BMP-4, BMP-5, and BMP-7 and receptors of BMPR-IA, BMPR-IB and BMPR-II was detected in ex vivo and cultured epithelium and stroma. The level of transcription was higher in cultured stroma for all factors, but the level for the receptors was higher in cultured epithelium. In contrast GDF-5 was transcribed only in stromal cells, suggesting that this cytokine may be an important mediator between keratocytes and epithelial cells. Furthermore, GDF-5 inhibited proliferation of corneal epithelial and stromal cells. CONCLUSIONS: Given the importance of the TGF-beta family during embryonic development, the results suggest that its members may be components of the corneal cytokine network and may participate in the regulation of cellular proliferation and differentiation. PMID- 9950589 TI - Automated quantification of keratocyte density by using confocal microscopy in vivo. AB - PURPOSE: To compare keratocyte density determined by using confocal microscopy with keratocyte density determined in the same corneas by histology. METHODS: Digital en face images of central corneas were recorded three times by using confocal microscopy in vivo in six New Zealand White rabbits. Bright objects (keratocyte nuclei) in the images were automatically identified by using a custom algorithm to estimate total and regional stromal keratocyte densities. The corneas were then excised, fixed, and sectioned in a sagittal plane for histology. Keratocyte nuclei were manually counted from digitized images of 50 histologic sections per cornea. Total and regional keratocyte densities were estimated from the histologic sections by using stereologic methods based on nuclei per unit area, mean nuclear diameter, and section thickness. Histologic cell densities were corrected for tissue shrinkage. RESULTS: By confocal microscopy, total keratocyte density was 39,000 +/- 1,200 cells/mm3 (mean +/- SE; n = 6); cell density was 47,100 +/- 1,300 cells/mm3 in the anterior stroma and decreased to 27,900 +/- 2,700 cells/mm3 in the posterior stroma (P = 0.004). Analysis of the three separate confocal images of each cornea produced repeatable total cell densities (mean coefficient of variation = 0.035). By histology, total keratocyte density was 37,800 +/- 1,100 cells/mm3, not significantly different from that estimated by confocal microscopy (P = 0.43); anterior cell density was 48,300 +/- 900 cells/mm3 and decreased to 29,400 +/- 900 cells/mm3 posteriorly (P < 0.001). CONCLUSIONS: Rabbit keratocyte density estimated by automated analysis of confocal microscopy images in vivo is repeatable and agrees with keratocyte density estimated from histologic sections. PMID- 9950590 TI - Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina. AB - PURPOSE: To investigate the nature and reversibility of biochemical and functional changes in the retina encountered over a single generation of dietary n-3 polyunsaturated fatty acid deficiency in guinea pigs. METHODS: Dunkin-Hartley guinea pigs were fed for 16 weeks after weaning with diets supplemented with safflower seed oil (n-3 deficient) or canola oil (n-3 sufficient, control). A number of deficient animals were repleted at 6 weeks with canola oil for 5 or 10 weeks, or at 11 weeks for 5 weeks. Electroretinograms (0.8 and 4.3 log scot td x sec) were collected at 6, 11, and 16 weeks after weaning. Conventional waveforms (a- and b-waves), oscillatory potentials, and receptoral and postreceptoral subcomponents (PIII and PII, respectively) were evaluated. Cone pathway function was assessed with 30-Hz flicker at the brighter intensity. Retinal phospholipid fatty acids were measured by capillary gas-liquid chromatography. RESULTS: Electroretinographic amplitudes showed statistically significant losses in b- and a-waves after 6 and 16 weeks of dietary n-3 deficiency, respectively. The response amplitude to 30-Hz flicker was reduced 42% after 16 weeks. Retinal docosahexaenoic acid (DHA) levels of animals maintained on the safflower oil diet for 16 weeks were 42% of levels in age-matched control subjects. There were significant losses in maximum response amplitudes (R(mPIII) and R(mPII)), although the major effect was a reduction in sensitivity of the receptoral response. Complete functional recovery was observed only in animals repleted for 10 weeks. CONCLUSIONS: Functional deficits in PIII and PII of the electroretinogram were apparent in first-generation guinea pigs fed an n-3 deficient diet. These losses showed a correlation with age and retinal DHA level, although varying degrees of dependence on the DHA level were found. All functional deficits were reversed after 10 weeks of dietary n-3 repletion. The results suggest that DHA may serve several functional and structural roles in the retina and further emphasize the requirement for DHA in the normal development of vision. PMID- 9950591 TI - Oscillopsia and tolerance to retinal image movement in congenital nystagmus. AB - PURPOSE: To determine the relationship between retinal image movement (RIM) and oscillopsia in subjects with idiopathic congenital nystagmus (CN). METHODS: Eye movements were recorded using an IRIS infrared system. The eye movement signal was fed back to move an otherwise stationary target on a screen and thereby modify the RIM experienced by each of the five CN subjects. The target was present with either no background (the absolute condition) or a textured background (the relative condition). Feedback gains were varied from -1.0 (i.e., 100% retinal image increase) to +1.0 (i.e., 100% retinal image decrease or complete stabilization), with 0 representing the zero feedback or stationary target condition. In the first experiment, RIM thresholds were determined for a range of feedback values. Using zero feedback, a second experiment measured the detection threshold for absolute and relative motions to a ramp-generated target movement for five CN and five control subjects. RESULTS: Under feedback control spatial constancy broke down for both increased and reduced RIM. The range of spatial constancy was greater for absolute (-0.56 to +0.44) compared with relative (-0.18 to +0.18) RIM. Motion detection thresholds for the CN group were 8 times less sensitive to the absolute and 17 times less sensitive to the relative motion of the target compared with the control group. CONCLUSIONS: These results suggest that in CN subjects perceptual stability is achieved primarily by extraretinal signals. PMID- 9950592 TI - Visual development in preterm and full-term infants: a prospective masked study. AB - PURPOSE: To compare development of visual acuity and binocular vision in preterm and full-term infants in a prospective study that used testers masked to subject's gestational age. METHODS: Seventy-nine healthy full-term infants, mean gestational age 40 weeks, and 18 low-risk preterm infants, mean gestational age 33 weeks, were examined biweekly between the 44th and 54th weeks of postmenstrual age. Ocular alignment, convergence, fusion, grating acuity, and onset of optokinetic nystagmus (OKN) were assessed at each examination. RESULTS: The mean postnatal ages of onset of ocular alignment, convergence, fusion, grating acuity to 1.6 cycles per degree, and OKN from temporal to nasal and nasal to temporal were, respectively, 5, 7, 7, 11, 6, and 9 weeks for the full-term and 12, 13, 14, 18, 13, and 16 weeks for the preterm infants. The mean postmenstrual ages of onset for the corresponding parameters were 46, 48, 48, 51, 46, and 50 weeks for full-term and 46, 47, 48, 52, 47, and 49 weeks for preterm infants. The onset of all parameters was earlier in full-term infants than in preterm infants of the same postnatal age (P < or = 0.0001). However, no differences were found when the parameters were compared at postmenstrual ages. CONCLUSIONS: Additional visual experience of preterm infants does not influence development of visual acuity or binocular vision during the first months of life as measured from the time of conception. PMID- 9950593 TI - Electrophysiological evidence of cortical fusion in children with early-onset esotropia. AB - PURPOSE: To investigate sensory fusion responses in infants and children with early-onset esotropia to gain insights into the sequence of events that leads to strabismus. METHODS: Sensory fusion was tested by measuring visual evoked potential (VEP) responses to dynamic random dot correlograms (DRDCs) in a group of children (n = 23) with early-onset esotropia. Thirteen children were tested before surgical alignment, and 13 children were tested after surgical alignment (three children were tested before and after surgery). If the angle of strabismus was larger than 5 prism diopters, it was corrected with Fresnel prisms (Fresnel Prism and Lens, Scottsdale, AZ). RESULTS: Five (38%) of the 13 children who were tested before surgery showed detectable VEP responses to correlogram stimuli compared with 11 (85%) of the 13 children who were tested after surgical alignment. There were no significant statistical differences between VEP responses to DRDCs from the postsurgery group and VEP responses from an age matched control group with normal binocular vision. CONCLUSIONS: The presence of cortical sensory fusion in children with early-onset esotropia suggests that a congenital defect of sensory fusion cannot be the root cause of esotropia in most children. The data suggest that sensory fusion, when measured by VEP responses to DRDCs, is more robust than stereopsis to abnormal binocular experience and support the notion that pathways processing correlated/anticorrelated stimuli may not completely overlap with pathways processing disparity information. PMID- 9950594 TI - Matrix metalloproteinase-1 localization in the normal human uveoscleral outflow pathway. AB - PURPOSE: To determine the distribution of matrix metalloproteinase-1 (MMP-1) in the uveoscleral outflow pathway and other anterior segment tissues of normal human eyes. METHODS: Normal human eyes were fixed in methacarn and sectioned and immunostained using a specific polyclonal antibody to MMP-1. Immunoreactivity was visualized using diaminobenzidine. To compare the staining intensity in various tissues, the mean optical density within the ciliary body, mid-iris stroma, iris root, uveal trabecular meshwork, cornea, and sclera was determined using imaging densitometry. To determine the cellular distribution of MMP-1 in ciliary muscle, additional sections were double-immunostained using antibodies to MMP-1 and calponin. These sections were examined by confocal laser scanning microscopy. Specificity of the antibody to MMP-1 in ocular tissues was confirmed by western blot analysis with uveal tract homogenates. RESULTS: Moderate-to-strong MMP-1 immunoreactivity was observed in ciliary muscle, iris, sclera, corneal endothelium, and ciliary nonpigmented epithelium. Lighter immunoreactivity was observed in corneal epithelium, blood vessels, trabecular meshwork, Schlemm's canal, and associated collector channels. Confocal microscopy showed that ciliary muscle MMP-1 was primarily inside ciliary muscle cells. Densitometry showed that net optical density was approximately fivefold greater in ciliary muscle, iris root, and sclera than in trabecular meshwork. CONCLUSIONS: MMP-1 was prominently identified in regions of the anterior segment of normal human eyes associated with the uveoscleral outflow pathway and in the iris, corneal endothelium, and ciliary nonpigmented epithelium. These data support the hypothesis that MMP-1 activity is involved in regulating uveoscleral outflow facility. PMID- 9950595 TI - Effects of topical beta-blockers on the diameter of the isolated porcine short posterior ciliary artery. AB - PURPOSE: Based on diameter measurements on the short posterior ciliary artery, this study was intended to determine the direct pharmacologic effect of beta blockers; to determine the differences among a selective beta-blocker betaxolol, a beta-blocker with intrinsic sympathetic activity befunolol, and a nonselective beta-blocker timolol; and to find experimental evidence for the indirect hemodynamic effect of beta-blockers. METHODS: A segment of isolated porcine short posterior ciliary artery was cannulated at both ends and mounted in a pressurized vessel chamber. Vessel diameter was measured as a function of beta-blocker concentration and as a function of change in transmural pressure. RESULTS: In the absence of flow, the mean effective doses (ED50) were 0.8 +/- 0.3 mM, 1.0 +/- 0.3 mM, and 11.6 +/- 6.6 mM (SEM) for betaxolol, befunolol, and timolol, respectively. In the presence of flow, vessel diameter increased with an increase of transmural pressure. The mean relative diameter increased 4.2% +/- 1.0% (SEM) at a transmural pressure step from 30 mm Hg to 60 mm Hg. This increase was not significantly dependent on the presence of any of the beta-blockers. CONCLUSIONS: Only at concentrations far exceeding their expected plasma concentrations, betaxolol, befunolol, and timolol increased the diameter of the isolated porcine short posterior ciliary artery, as a result of their direct pharmacologic effect. Only the difference between the vasodilatory potency of the selective and the nonselective beta-blocker was significant: ED50 of betaxolol was 15 times smaller than ED50 of timolol. There was a positive correlation between the diameter of the isolated porcine short posterior artery (when used as a model for an intraocular artery) and the transmural pressure, which corroborates the indirect hemodynamic effect of beta-blockers. It is speculated that instillation of topical beta-blockers into the conjunctival sac may increase the perfusion of the optic nerve head by an indirect hemodynamic mechanism, but not by a direct pharmacologic mechanism. PMID- 9950596 TI - Comparative antiviral efficacies of cidofovir, trifluridine, and acyclovir in the HSV-1 rabbit keratitis model. AB - PURPOSE: To determine the relative antiviral inhibitory activity of topical 1% and 0.5% cidofovir, topical trifluridine (Viroptic; Burroughs-Wellcome, Research Triangle Park, NC), and topical acyclovir (Zovirax; The Wellcome Foundation, London, UK) during a 7-day period for the treatment of herpes simplex virus type 1 (HSV-1) keratitis and HSV-1 replication in the New Zealand rabbit ocular model. METHODS: In a series of four experiments using a two-eye design, a total of 80 New Zealand rabbits were inoculated in both eyes with HSV-1 McKrae after epithelial scarification. Forty-eight hours after inoculation, the rabbits were randomly assigned to a treatment group. Five treatment groups (16 rabbits/group) were evaluated: I, 1% cidofovir, twice daily for 7 days; II, 0.5% cidofovir, twice daily for 7 days; III, 3% acyclovir ointment, five times daily for 7 days; IV, 1% trifluridine, nine times daily for 3 days, then 4 times daily for 4 days; and V, control vehicle twice daily for 7 days. HSV-1 dendritic keratitis was graded in a masked fashion by slit-lamp examination on days 2, 3, 5, 7, 9, 11, and 14. Ocular viral cultures were obtained after slit-lamp examination on days 1, 3, 5, 7, 9, 11, and 14. RESULTS: Compared with the control group, all four treatment groups demonstrated significantly lower viral titers, fewer HSV-1 positive eyes/total during the treatment period, lower keratitis scores, fewer eyes with keratitis/total, and a shorter time to resolution of keratitis. Within the treatment groups, the 1% and 0.5% cidofovir treatments were significantly more effective than acyclovir and trifluridine as measured by the previous viral and keratitis parameters. CONCLUSIONS: Topical 1% and 0.5% cidofovir both appeared to be significantly more efficacious than topical trifluridine and acyclovir, during a 7-day course, in the treatment of experimental HSV-1 ocular disease in the New Zealand rabbit keratitis model. PMID- 9950597 TI - Acute inflammation of the eyelid and cornea in Staphylococcus keratitis in the rabbit. AB - PURPOSE: The inflammatory response during Staphylococcus keratitis was analyzed biochemically and histologically to determine the source of the neutrophils infiltrating the tear film and cornea. METHODS: Rabbit eyes were swabbed and then examined by slit-lamp microscopy at 0, 5, 10, 15, 20, and 25 hours after intracorneal inoculation with Staphylococcus aureus. Bacterial colony-forming units were quantified in the cornea, eyelid, and acute inflammatory exudate. Myeloperoxidase activity of ocular swabs of acute inflammatory exudate, corneal homogenates, and eyelid homogenates was determined. Gross and microscopic examinations of corneas and eyelids were performed. RESULTS: The colony-forming units per cornea exceeded 10(7) after 10 hours, whereas no bacteria were cultured from the eyelid until 15 hours postinfection. Slit-lamp examination revealed progressive pathology, and the myeloperoxidase activities of ocular swabs, corneas, and eyelids increased markedly by 15 hours postinfection. Corneas showed a wave of neutrophils moving from the tear film toward bacteria in the central corneal stroma and early neutrophil migration from the limbus into the stroma. In the eyelid, neutrophils migrated from the stromal vessels to the tear film. CONCLUSIONS: Staphylococcus keratitis in the rabbit causes acute inflammation in the overlying eyelid. Neutrophils of the acute inflammatory exudate interact with the infected cornea, whereas neutrophils migrating through the cornea from the limbus remained distant from the site of infection. PMID- 9950598 TI - The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis. AB - PURPOSE: To perform a detailed examination of the immunomodulatory effects of topical cyclosporin A (CsA) in conjunctival tissue from patients with atopic keratoconjunctivitis (AKC). METHODS: Patients with active AKC were randomly allocated into two groups of four patients. For 3 months one group received 2% CsA drops, and the other group received placebo drops. Superior tarsal conjunctival biopsy specimens were harvested before and after treatment and examined by one- and two-color immunohistochemistry to compare leukocyte counts, HLA-DR+ and IL-2R+ cell counts, HLA-DR positivity of conjunctival epithelial cells, and counts of T cells expressing the cytokines interleukin (IL)-2, IL-3, IL-4, IL-5, and interferon (IFN)-gamma. RESULTS: Posttreatment values were significantly less than pretreatment values for the total number of leukocytes and in the numbers of CD3+ T cells, CD4+ cells, CD8+ cells, CD20+ B cells, neutrophils, and macrophages, and there was a decrease in the CD4-CD8 ratio (P = 0.03) in the CsA group. There was a reduction from before CsA treatment to after CsA-treatment in the numbers of HLA-DR+ and IL-2R+ cells (P = 0.03), but the reduction in the epithelial cell HLA-DR expression did not reach significance. The number of T cells staining for IL-3 and IL-5 was reduced, although not to statistical significance, but there was a significant reduction in the number of T cells expressing IL-2 and IFN-gamma (P = 0.03) after CsA treatment compared with initial values. There were no statistically significant differences between pretreatment and posttreatment values in the placebo group. There was a clinical improvement in the CsA group and a clinical worsening in the placebo group. CONCLUSIONS: The in vitro effects of CsA translate into a reduction in T cells, a normalization of the CD4-CD8 ratio, a decrease in T-cell activation, and a reduction in T-cell cytokine expression, especially IL-2 and IFN-gamma. The decrease in HLA-DR expression may be mediated by the change in IFN-gamma. There were fewer B cells but not fewer plasma cells after CsA and no change in IL-4 expression, suggesting minimal effects on type I hypersensitivity responses. There was no significant reduction in mast cell or eosinophil numbers, but direct effects of topical CsA on their function may play a role in the therapy of ocular allergic disease. These results show that the beneficial effects of topical CsA in AKC are accompanied by important changes in conjunctival immune cell profiles. PMID- 9950599 TI - Oxidative stress induces differential gene expression in a human lens epithelial cell line. AB - PURPOSE: To identify differentially expressed genes in a human lens epithelial cell line exposed to oxidative stress. METHODS: Reverse transcriptase-polymerase chain reaction (RT-PCR) differential display was used to evaluate differential gene expression in a human lens epithelial cell line (SRA 01-04) when cells were exposed for 3 hours to a single bolus of 200 microM hydrogen peroxide. Differentially expressed genes were identified through DNA sequencing and a nucleotide database search. Differential expression was confirmed by northern blot and RT-PCR analyses. RESULTS: Using 18 primer sets, 28 RT-PCR products were differentially expressed between control and hydrogen peroxide-treated cells. In stressed cells, mitochondrial transcripts nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 4 and cytochrome b were downregulated 4-fold. Of the cytoplasmic mRNAs, glutamine cyclotransferase decreased 10-fold, whereas cytokine inducible nuclear protein, alternative splicing factor 2, and beta hydroxyisobutyryl-coenzyme A hydrolase increased 2-, 4-, and 10-fold, respectively. Analysis of mitochondrial transcripts in a 24-hour time course showed that NADH dehydrogenase subunit 4 mRNA decreased by 2-fold as early as 1 hour after oxidative stress, whereas the rate of decrease was slower for cytochrome b, cytochrome oxidase III, and 16S rRNA. CONCLUSIONS: Oxidative stress induced specific expressed gene changes in hydrogen peroxide-treated lens cells, including genes involved in cellular respiration and mRNA and peptide processing. These early changes may reflect pathways involved in the defense, pathology, or both of the lens epithelium, which is exposed to oxidative stress throughout life. PMID- 9950600 TI - The effects of digitalis-like compounds on rat lenses. AB - PURPOSE: Fundamental to the maintenance of ionic concentration gradients and transparency of the lens is the activity of Na+,K+-adenosine triphosphatase (ATPase) in the epithelial layer. Recent studies have identified endogenous digitalis-like compounds (DLCs) and 19-norbufalin and its peptide derivatives in human cataractous lenses. These compounds inhibit the activity of Na+,K+-ATPase and have been suggested to be involved in cataract formation. The present experiments were designed to test this hypothesis by determining the ability of digitalis and DLCs to induce changes in protein composition and leakage from rat lenses in organ culture. METHODS: DLCs were determined in rat lenses using three independent assays: interaction with ouabain antibodies, interaction with bufalin antibodies, and inhibition of [3H]-ouabain binding to red blood cells. Rat lenses were incubated in modified TC-199 medium in 5% CO2 atmosphere at 37 degrees C for the time of the experiment. The onset of cataractogenesis was assessed by measuring protein leakage from lenses and by crystallin composition in the lens and media. RESULTS: DLCs were present in rat lens with concentrations 7 to 30 times higher in the capsular-epithelial layer than in the lens fibers regions. Ouabain, bufalin, digoxin, and DLC induced dose- and time-dependent leakage of protein from rat lenses. Lenses incubated with these compounds showed alterations in crystallin content consistent with changes that initiate opacity. All the compounds caused a multilayering of epithelial cells in the region surrounding the mitotic area and, at the same time, cell death in the central anterior region. CONCLUSIONS: Digitalis and endogenous DLCs are cataractogenic factors. These results, together with the demonstration of DLCs in the normal lens and their increased levels in human cataractous lenses, strongly suggest their involvement in the molecular mechanisms responsible for cataract formation. PMID- 9950601 TI - Effects of intramuscular injection of botulinum toxin and doxorubicin on the survival of abducens motoneurons. AB - PURPOSE: To investigate in vivo the survival of abducens motoneurons (AMNs) at different periods of time after a single intramuscular injection of the neurotoxin botulinum toxin A (BTxA) or doxorubicin (DXR). METHODS: In Sprague Dawley rats, the AMNs were labeled with fluorogold (FG), which was applied intramuscularly in the lateral rectus muscle. The numbers of labeled neurons were determined in adult control animals; in young animals that had received intramuscular injections of 0.125, 0.250, 1, or 2 U BTxA; and in adult rats that had received 100 microg, 200 microg, or 300 microg DXR, at various survival times. RESULTS: In control animals, the numbers of FG-labeled motoneurons were similar to the numbers found by other investigators with the use of other retrogradely transported tracers; motoneuron numbers diminished with time after FG application. The numbers of FG-labeled neurons in the animals that had been injected with BTxA were similar to those found in control animals. However, there were fewer FG-labeled neurons in the animals injected with DXR. CONCLUSIONS: Fluorogold injected into the lateral rectus muscle can be used to label the AMNs. However, this tracer does not persist within the cytoplasm of the labeled neurons for more than 37 days. The intramuscular injection of 0.125, 0.250, 1, or 2 U BTxA does not induce significant motoneuron death in young rats 30, 60, or 90 days after the injection. Doxorubicin injected intramuscularly causes variable amounts of motoneuron death that is related both to the survival period and to the amount of DXR injected. PMID- 9950602 TI - Na-K-Cl cotransport in normal and glaucomatous human trabecular meshwork cells. AB - PURPOSE: Previous results from this laboratory showed that intracellular volume of trabecular meshwork (TM) cells is regulated by the Na-K-Cl cotransport system. Other studies suggest that TM cell volume, in turn, is a determinant of permeability across the TM. Given that a decrease in outflow facility across the TM is thought to be the primary cause of elevated intraocular pressure in primary open-angle glaucoma, the present study was conducted to investigate the possibility that Na-K-Cl cotransport function may be altered in glaucomatous TM cells compared with normal TM cells. METHODS: Normal and glaucomatous human TM cells were cultured from donor eyes and trabeculectomy specimens, respectively. Trabecular meshwork cell monolayers were evaluated for Na-K-Cl cotransport activity, assessed as ouabain-insensitive, bumetanide-sensitive K influx using 86Rb as a tracer for K. Cotransporter protein expression was determined by western blot analysis, and intracellular volume was determined radioisotopically using [14C]urea and [14C]sucrose as markers of total and extracellular water space, respectively. RESULTS: Na-K-Cl cotransport activity of glaucomatous TM cells was found to be reduced by 32% +/- 2% compared with that of normal TM cells, whereas western blot analyses showed that cotransporter protein expression in glaucomatous TM cells was reduced by 64% +/- 14% compared with expression in normal TM cells. Also, exposure of normal TM cells to 10 microM norepinephrine or 50 microM 8-bromo-3',5'-cyclic adenosine monophosphate was found to diminish Na-K Cl cotransport activity, whereas these agents were without effect on glaucomatous TM cell cotransport. Finally, resting cell volume of glaucomatous TM cells was found to be increased compared with that of normal TM cells, whereas intracellular volume of both cell types was reduced after exposure to 10 microM benzmetanide or 10 microM bumetanide. CONCLUSIONS: These findings indicate that Na-K-Cl cotransport function and regulation are altered in glaucomatous TM cells compared with that of normal TM cells. However, the observation that cell volume of glaucomatous TM cells is greater than that of normal TM cells, despite reduced Na-K-Cl cotransport activity, suggests that other volume-regulatory ion flux pathways may be involved in the reduced outflow of glaucoma. PMID- 9950603 TI - Neuropsychological impairment-associated visual field deficits in HIV infection. HNRC Group. HIV Neurobehavioral Research Center. AB - PURPOSE: To examine the relationship between loss in peripheral visual sensitivity and neuropsychological functioning in seropositive patients with human immunodeficiency virus (HIV) without infectious retinopathy. METHODS: Subjects carefully screened for retinal disease and well-matched across demographic and medical variables were grouped according to normal (perimetry-nl) versus abnormal (perimetry-abnl) performance on achromatic automated perimetry and short-wavelength automated perimetry, standard clinical ophthalmologic measures of visual function. All subjects completed a detailed neuropsychological test battery and were classified as impaired or unimpaired, globally and across eight neurocognitive domains. Subjects were also classified according to whether they met diagnostic criteria for minor cognitive/motor disorder (MCMD) or HIV associated dementia (HAD). RESULTS: Visual field loss was associated with lower performance in the abstraction, perceptual-motor, learning, and motor domains. Significant group differences were also found on numerous individual neuropsychological tests. Based on clinical ratings, we found deficits in learning and motor functioning. No perimetry-nl subjects met criteria for MCMD or HAD, whereas 32% of perimetry-abnl subjects met diagnostic criteria for syndromic cognitive disorders (five MCMD and one HAD). In a subset of subjects who underwent a lumbar puncture, there was a trend for the perimetry-abnl group to have a higher concentration of beta2 microglobulin, a marker for central nervous system immune activation. CONCLUSIONS: These results suggest that in some HIV infected people reduced visual function may be caused by nonretinal disease, and perimetry may present a sensitive measure of HIV-related brain dysfunction. PMID- 9950604 TI - The relationships of age changes in retinal pigment epithelium and Bruch's membrane. AB - PURPOSE: To study the correlations between age, Bruch's membrane (BM) thickness, retinal pigment epithelial (RPE) autofluorescence, and RPE residual body content. METHODS: Eight-millimeter-diameter macular discs from 88 unpaired human eye bank eyes were obtained within 72 hours of death, fixed in 10% neutral buffered formalin, and hemisected horizontally. One portion of the macular disc was embedded in paraffin and stained with periodic acid-Schiff for the measurement of BM thickness. RPE autofluorescence measurements were performed on unstained, deparaffinized sections. A second portion of the macular disc was prepared for electron microscopy to evaluate RPE residual body content. Linear and polynomial regression techniques were used to investigate the correlations between age, BM thickness, RPE autofluorescence, and RPE residual body content. RESULTS: Bruch's membrane thickness increased with age according to the linear model. RPE autofluorescence and RPE residual body content also increased with age, but the correlations were best approximated by a quadratic model. The correlations between RPE autofluorescence and residual body content and between BM thickness and RPE autofluorescence were best approximated by a linear regression model. There was considerable variation in these correlations between specimens and within the same age group. CONCLUSIONS: Although the changes in RPE and Bruch's membrane increased with age and there was a direct correlation between changes in the two tissues, there was considerable variation within each age group and between specimens. This probably reflects the multifactorial nature of the process. PMID- 9950605 TI - Roles of constitutive nitric oxide synthase in postischemic rat retina. AB - PURPOSE: Nitric oxide is a reactive species that could be protective or destructive to the retina depending on the stage of the evolving ischemic process. This study was conducted to obtain a better understanding of the roles of constitutive nitric oxide synthase (cNOS) during reperfusion after ischemia in rat retina. METHODS: Retinal ischemia was induced for 60 minutes in Sprague Dawley rats by ligating the optic nerve. Gene expression for endothelial and neuronal nitric oxide synthases (eNOS and nNOS) was studied by reverse transcription-polymerase chain reaction (RT-PCR). To inhibit cNOS, NG-nitro-L arginine (L-NNA) was injected intraperitoneally four times (every 6 hours) beginning 2 hours after reperfusion, for a total dose of 80 mg/kg. Retinal damage was assessed by the rate of a- and b-wave recovery on electroretinograms and by the thickness of the retinal layers. Retinal circulation and vessel diameter were evaluated by the dye-dilution technique. RESULTS: After ischemia ended, eNOS mRNA initially decreased until 6 hours, then increased to a peak at 12 hours, and decreased progressively beyond 24 hours until the final measurement at 96 hours of reperfusion. nNOS mRNA decreased to nearly undetectable levels during the same measurement periods. L-NNA treatment enhanced reduction of a- and b-wave amplitudes and increased thinning of the inner retina in postischemic eyes. Retinal mean circulation time was markedly prolonged in L-NNA-treated postischemic eyes. Arterial mean transit times were 2.1-fold and 4.5-fold longer in L-NNA-treated postischemic eyes than in L-NNA-treated nonischemic eyes and in D-NNA-treated postischemic eyes, respectively. CONCLUSIONS: This study shows that postischemic inhibition of NOS worsens retinal damage after ischemia-reperfusion and alters postischemic retinal circulation. Nitric oxide may play an important role in protecting the retina from ischemic injury, possibly by preventing postischemic hypoperfusion. PMID- 9950606 TI - Suppression of laser-induced choroidal neovascularization by oral tranilast in the rat. AB - PURPOSE: To determine whether tranilast administered to pigmented rats inhibits formation of choroidal neovascularization induced by diode-laser photocoagulation. METHODS: Female Brown Norway rats were used. On day 0, choroidal neovascularization was induced by diode-laser photocoagulation, using a setting of 75 microm spot size, 0.1 second's duration, and 100 mW intensity. Tranilast (200 or 600 mg/kg per day) was administered orally twice daily for 14 days. Indomethacin (1 and 5 mg/kg per day) was administered orally once a day for 14 days. Choroidal neovascularization was evaluated on days 7 and 14 by fundus photography and fluorescein angiography. Late-phase fluorescein angiography was scored according to four grades. The animals were killed on day 14, and the lesions were evaluated histologically. RESULTS: In the vehicle-treated group, 34 of 35 burns (97%) showed fluorescein staining and late leakage on day 14. Choroidal neovascularization was identified by light microscopy in all the lesions that showed fluorescein staining and late leakage. The score of fluorescein staining was reduced in rats given 200 mg/kg per day or 600 mg/kg per day (P < 0.01) of tranilast. The thickness of the laser-induced lesions was reduced in a dose-dependent manner by tranilast, a significant difference was observed with 600 mg/kg per day (P < 0.05). Oral indomethacin treatment did not reduce fluorescein staining on day 14. CONCLUSIONS: Tranilast inhibits the development of choroidal neovascularization in this experimental model. PMID- 9950607 TI - Fate of human retinal pigment epithelial cells seeded onto layers of human Bruch's membrane. AB - PURPOSE: To determine the fate of human retinal pigment epithelial (RPE) cells seeded onto different layers of human Bruch's membrane (BM). METHODS: Bruch's membrane explants were prepared from 16 human cadaver eyes (7 eyes age <50 years; 9 eyes >50 years) by removing native RPE cells with ammonium hydroxide to expose the RPE cell basal lamina (BL). The inner collagenous layer (ICL) and elastin layer (EL) were exposed by removing apical layers sequentially by mechanical and enzymatic means. Synchronized first passage human RPE cells (15,000 cells/(6-mm diameter explant) were plated onto each layer of human BM. The RPE cell reattachment and apoptosis rates at 24 hours, proliferation rates and mitotic index 24 hours after growth stimulation, and the ability of RPE cells to repopulate the explant surface were determined on each layer. RESULTS: RPE cell reattachment was highest on BL but decreased on deeper layers of BM. The apoptosis rate of attached cells increased as deeper layers of BM were exposed. The proliferation rate and mitotic index of the grafted cells were higher on BL than on deeper layers. RPE cells plated onto BL repopulated the explant surface within 14 +/- 3 days, whereas cells plated onto the ICL and EL eventually died and never reached confluence. CONCLUSIONS: The fate of RPE cells seeded onto BM depends on the ultrastructural layer of BM available for reattachment. These findings suggest that the ability of transplanted RPE cells to repopulate bare BM will depend on the layer of BM available for RPE cell reattachment. PMID- 9950608 TI - Suppression of NF-kappaB-dependent proinflammatory gene expression in human RPE cells by a proteasome inhibitor. AB - PURPOSE: To determine whether nuclear transcription factor-kappaB (NF-kappaB) is activated in human retinal pigment epithelial (hRPE) cells in response to interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), or interferon-gamma (IFN-gamma) alone or in combination and if so, whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor, MG-132, which inhibits the degradation of I kappaB, an NF kappaB inhibitor, thereby preventing nuclear translocation of NF-kappaB. METHODS: Cultured hRPE were pretreated for 60 minutes with medium alone or medium containing the proteasome inhibitor MG-132 (20 microM) and then exposed to TNF alpha (1.1 x 10(3) U/ml), IL-1beta (5 U/ml), or IFN-gamma (7.5 x 10(3) U/ml) alone or in combination (TII). Nuclear translocation of NF-kappaB was determined by fluorescence staining of the NF-kappaB Rel A (p65) subunit. Cytoplasmic I kappaB protein was measured by western blot analysis. Nuclear extract binding to kappaB DNA motifs was measured by electrophoretic mobility shift assay and antibody supershift assay. Steady state mRNA expression of the chemokines melanoma growth stimulating activity (MGSA)/gro-alpha, regulated on activation normal T-cell expression and secreted (RANTES), and monocyte chemoattractant protein (MCP-1), the cytokines IL-1beta and macrophage colony stimulating factor (M-CSF) and intercellular adhesion molecule-1 (ICAM-1) was evaluated by semiquantitative reverse transcription-polymerase chain reaction. Chemokine and cytokine protein secretion was measured by enzyme-linked immunosorbent assay. Cell-surface ICAM-1 expression was determined by flow cytometry. RESULTS: TNF alpha, IL-1beta, and TII but not IFN-gamma alone caused degradation of I kappaB, Rel A nuclear translocation, and increased NF-kappaB DNA binding activity, effects that were blocked by pretreatment with MG-132. MG-132 suppressed MGSA/gro alpha, RANTES, MCP-1, IL-1beta, M-CSF, and ICAM-1 mRNA expression and secreted RANTES, MCP-1, and M-CSF protein, and cell-surface ICAM-1 that were induced by IL 1beta, TNF-alpha, and TII. CONCLUSIONS: TNF-alpha, IL-1beta, and TII induce expression of proinflammatory cytokines and ICAM-1 in hRPE cells through an NF kappaB-dependent signal transduction pathway. This effect is blocked by MG-132, a proteasome inhibitor that prevents I kappaB degradation. Inhibition of NF-kappaB may be a useful strategy to treat proliferative vitreoretinopathy and uveitis, ocular diseases initiated and perpetuated by cytokine activation. PMID- 9950609 TI - Histamine immunoreactive axons in the macaque retina. AB - PURPOSE: The goal of these experiments was to identify the neurotransmitter in centrifugal axons of the macaque retina. METHODS: Macaca mulatta retinas and optic nerves were fixed overnight in carbodiimide and labeled with an antiserum to histamine with the use of an immunofluorescence technique. RESULTS: Several large histamine-immunoreactive axons ran from the optic nerve head to the peripheral retina, where they branched extensively and terminated in the inner plexiform layer, occasionally alongside retinal blood vessels. Other axons that emerged from the optic nerve head ran in the optic fiber layer to the central retina, circled the fovea, and then returned to the optic disc. These may be the source of histamine-immunoreactive axons that have been observed in central visual areas. No labeled cell bodies were present in the retina. Because perikarya in the posterior hypothalamus are the only known source of histamine in the primate central nervous system and because neurons there can be retrogradely labeled from the cut optic nerve, the histamine-immunoreactive axons must have originated there. CONCLUSIONS: Centrifugal axons in the macaque retina are part of the system of axons containing histamine that originate in the hypothalamus and project throughout the brain. Because the activity of these neurons is highest during the morning, histamine might play a role in preparing the retina to operate in daylight. The contacts of histamine-immunoreactive axons with blood vessels suggest that histamine may also play a role in regulating the retinal microvasculature. PMID- 9950610 TI - Agreement between grating acuity at age 1 year and Snellen acuity at age 5.5 years in the preterm child. Cryotherapy for Retinopathy of Prematurity Cooperative Group. AB - PURPOSE: To examine the relation between grating acuity at age 1 year and Snellen acuity and grating acuity at 5.5 years, in preterm children with birth weights less than 1251 g. METHODS: Subjects were participants in the multicenter study of Cryotherapy for Retinopathy of Prematurity. The Teller acuity card (TAC; Vistech Consultants, Dayton, OH) procedure was used to measure monocular grating acuity in children at ages 1 and 5.5 years. Early-treatment diabetic retinopathy study (ETDRS) charts were used to measure the childrens' monocular recognition (Snellen) acuity at age 5.5 years. Data are presented for 575 eyes with measurable TAC grating acuity at 1 year and 111 eyes that had no measurable acuity at 1 year. RESULTS: Among eyes with normal acuity at 1 year, 86.8% showed normal Snellen acuity, and 94.3% showed normal grating acuity at 5.5 years. Among eyes that were blind (i.e., had no measurable TAC grating acuity) at 1 year, 96.8% showed no quantifiable Snellen acuity, and 89.2% showed no quantifiable grating acuity at 5.5 years. Only 2.4% of eyes had acuity in the range between normal and blind at 1 year (i.e., measurable grating acuity <1.6 cyc/deg); thus, the predictive value of acuity scores in this range could not be determined. Correlation analysis indicated that the relative position within the normal range of an eye's grating acuity score at 1 year was not predictive of the relative position within the normal range of that eye's acuity score at 5.5 years. CONCLUSIONS: Among a large population of low-birth-weight infants, eyes with normal grating acuity at age 1 year generally showed normal Snellen and grating acuity at age 5.5 years, and eyes that had no quantifiable acuity at 1 year remained blind at 5.5 years. Relative position of an eye's acuity score within the normal range was not predictive of the relative position of that eye's later acuity score. PMID- 9950611 TI - Crowding in central and eccentric vision: the effects of contour interaction and attention. AB - PURPOSE: To quantify the crowding effect with eccentric stimuli and to determine the relative contribution of neural interaction and attention to crowding in central and eccentric vision. METHODS: Monocular visual acuity was measured with computer-generated tumbling E and Landolt C targets presented centrally or at 2 degrees in the right visual field. Crowding distractors were designed to cause increasing contour interaction or increasing need for focused attention. A four alternative forced-choice method of constant stimuli was used. In experiment 2 the distance between the target and the distractors was varied. RESULTS: Data are presented in terms of normalized visual acuity. Crowding in central vision was minimal, mainly caused by contour interaction, and did not occur with distractors more than four stroke widths distant. Crowding in eccentric vision was far greater in magnitude and extent (occurring for distractors as far as 16 stroke widths distant) and was caused by contour interaction and attentional factors. CONCLUSIONS: The results indicate that eccentric vision differs quantitatively and qualitatively from central vision. The extent of contour interaction effects are consistent with the proposed size of cortical processing zones. The results are discussed with reference to current theories of preattentive and attentive tasks and with reference to subjects with low vision due to central scotoma who use an eccentric retinal locus for fixation. PMID- 9950612 TI - Measurement of corneal sensitivity to mechanical and chemical stimulation with a CO2 esthesiometer. AB - PURPOSE: To develop an instrument to measure corneal sensitivity. Mechanical stimulation was performed with increasing air flow. Chemical stimulation consisted of local pH decreases induced by a mixture of air and CO2 at different concentrations. METHODS: Air and 98.5% CO2 were mixed with an electronic, proportional-direction control valve to obtain gas mixtures from 0% to 80% CO2. The regulated outflow of gas was carried to a probe mounted on a slit lamp holder, where it was warmed and its CO2 concentration monitored. An electronic valve directed gas pulses of controlled duration to the cornea. Corneal stimulation was performed in 17 young human subjects. The intensity of the experienced sensation was recorded in a continuous visual analog scale (VAS). To obtain threshold values and intensity-response curves, 3-second pulses were applied. For mechanical stimulation, air pulses of increasing flow were used. For chemical stimulation, gas mixtures of increasing CO2 concentration at subthreshold flow and CO2 in stepped increases of 5% was applied. RESULTS: Mechanical and chemical stimulation of the cornea evoked a brief sensation of irritation. Mechanical threshold (flow values) varied among subjects but were reproducible within each subject and were higher with warmed air. The magnitude of the sensation increased proportionally to the flow of air. The mean chemical stimulation threshold (CO2 concentration) was 25% +/- 3%. Increases in CO2 concentration from 10% to 80% augmented proportionally the intensity of the evoked sensation. CONCLUSIONS: The gas esthesiometer, which combines variable air flow and CO2 concentrations, permits application to the cornea of mechanical stimuli of controlled force and pH reductions of increasing magnitude. This instrument may be useful in a separate exploration of mechanical and chemical sensitivity of the cornea in human subjects. PMID- 9950613 TI - Cell surface regulators of complement, 5I2 antigen, and CD59, in the rat eye and adnexal tissues. AB - PURPOSE: Cell surface complement regulatory proteins have been identified in high levels in ocular tissues, but no experimental model is available for examining their physiological roles. To develop such a model, the distribution of 5I2 antigen, a protein possessing the functions of the human decay-accelerating factor (DAF [CD55]) and membrane cofactor protein (MCP [CD46]), and rat inhibitory protein (CD59), the homologue of the human membrane inhibitor of reactive lysis (MIRL[CD59]) were characterized in the rat eye and ocular adnexal structures. METHODS: After euthanasia of female Wistar rats, followed by orbital exenteration, eyelids and orbital tissue including the lacrimal gland were separated from the globes and immediately snap-frozen in liquid nitrogen at -70 degrees C. Tissues then were sectioned at -20 degrees C and examined immunohistochemically for 5I2 antigen and rat CD59. RESULTS: Both molecules were found to be present in high levels in multiple sites. Corneal and conjunctival epithelia showed moderate to intense labeling for both regulators. Fibroblasts in the corneal stroma, conjunctiva, and sclera labeled similarly. Corneal endothelial cells showed intense labeling for rat CD59 but not for 5I2 antigen. The iris and ciliary body showed intense labeling for both proteins. The retina showed labeling at multiple levels, with that of rat CD59 being more intense than that of 5I2 antigen. The lacrimal gland labeled for both regulators. Vessels, muscle, and nerves in the orbit labeled intensely for both antigens. In the eyelid, conjunctiva, sebaceous glands, and muscle and nerve tissues labeled moderately to intensely for both molecules, whereas skin epithelium labeled less intensely. CONCLUSIONS: 5I2 antigen and rat CD59 are expressed in high levels and distributed similarly in the rat eye and lacrimal gland to DAF, MCP, and MIRL in the human eye and lacrimal gland. These findings establish the rat ocular surface as a model for studying the role of cell surface complement regulators in this site. This first identification of copious expression of these proteins in eyelid structures, which also participate in protection of the ocular surface, further suggests an important role for surface complement regulatory proteins in this location. PMID- 9950614 TI - Cellular response in subretinal neovascularization induced by bFGF-impregnated microspheres. AB - PURPOSE: To determine the sequence of cellular changes associated with a new rabbit model of subretinal neovascularization (SRN) induced by subretinal injection of basic fibroblast growth factor (bFGF)-impregnated microspheres. METHODS: bFGF-impregnated gelatin microspheres, prepared by forming a polyion complex between gelatin and bFGF, were subretinally implanted into rabbit eyes. The eyes were studied by immunochemistry at 3 days to 8 weeks after implantation. Antibodies to CD4, CD8, cytokeratin, CD31, glial fibrillary acidic protein (GFAP), and RAM11 were used. RESULTS: Cytokeratin-positive retinal pigment epithelial (RPE) cells appeared on day 3 and continued to increase in number in the subretinal space throughout the growth of the SRN membrane, becoming the predominant cell type. Macrophages (RAM11-positive) appeared early, but most disappeared within 7 days. GFAP-positive Muller cells were evident early in the retina but migrated into the subretinal space after 7 days; the gliotic adhesion they formed between the retina and the SRN membrane was prominent at 8 weeks. CD31-positive endothelial cells were first evident at 14 days and formed neovascular channels that were still present for up to 8 weeks. CD4- and CD8 positive lymphocytes appeared in the early stages but were few in number. CONCLUSIONS: SRN membranes are primarily composed of RPE cells and vascular endothelial cells. The membrane adheres to the retina by a gliotic band. The cellular components involved in the membrane of this model resemble those found in SRN membranes removed from patients with age-related macular degeneration. PMID- 9950615 TI - A possible role for p16INK4 in neuronal cell death after retinal ischemia reperfusion injury. AB - PURPOSE: To study whether cell type-specific death occurs in retinal ischemia reperfusion injury and the possible roles of p16INK4 in the determination of cell death. METHODS: Retinal ischemia-reperfusion injury was induced in rats by a ligation method. After 1 hour of ischemia and a time of reperfusion that varied, rat eyes were enucleated. Cell death in the retina was studied by the TdT-dUTP terminal nick-end labeling method and propidium iodide (PI) staining. Electron microscopic observation of the retina was also performed. Immunohistochemical studies using antibodies against syntaxin and calbindin were performed to detect amacrine cells and horizontal cells, respectively, and immunohistochemical studies using an antibody against p16INK4 were performed to study whether this cell cycle-related protein was expressed in dying cells. RESULTS: Most of the calbindin-positive horizontal cells in the outer aspect of the inner nuclear layer (INL) showed morphologic features of necrosis. In contrast, syntaxin positive amacrine cells in the inner aspect of the INL showed features of apoptosis. Of 320 calbindin-positive horizontal cells, only 11 (3.4%) showed positive PI staining. Those calbindin-positive, horizontal cells were p16INK4 positive. In contrast, 746 of 910 (82.0%) syntaxin-positive amacrine cells showed condensed PI staining, and none were p16INK4 positive. CONCLUSIONS: Expression of p16INK4 may regulate the fate of retinal neurons in ischemia-reperfusion injury, and cell type-specific death thus occurs in the retina after such injury. PMID- 9950616 TI - Polarity of 11-cis retinal release from cultured retinal pigment epithelium. AB - PURPOSE: Fetal bovine retinal pigment epithelium (RPE) was grown on porous supports to investigate the polarity of 11-cis retinal (RAL) release from these cells and the influence that the interphotoreceptor retinoid-binding protein (IRBP) has on this process. METHODS: [3H]all-trans retinol (ROL) was delivered to the basal surface of the cultured RPE by serum retinol-binding protein (RBP). Apo IRBP was added to either the apical or basal medium, or was absent from the incubation entirely. RESULTS: The greatest level of [3H]11-cis RAL was detected in the apical medium but only when apo IRBP was present there. When apo IRBP was present only in the basal medium, or was absent from the incubation entirely, low levels of [3H]11-cis RAL were released apically and basally. CONCLUSIONS: If 11 cis RAL release were constitutive, one would expect to find elevated levels of this retinoid in the apical and basal media in the absence of apo IRBP. Instead, the enhancement of [3H]11-cis RAL release into the apical, but not the basal, medium in the presence of apo IRBP suggests that [3H]11-cis RAL release is polarized and dependent on the presence of apo IRBP. It is postulated, therefore, that a mechanism such as an IRBP membrane receptor in the apical plasma membrane may be responsible for this polarity. PMID- 9950617 TI - Prevention of lens damage associated with cigarette smoke exposure in rats by alpha-tocopherol (vitamin E) treatment. AB - PURPOSE: To evaluate the possible protective effect and mechanism of alpha tocopherol (vitamin E) treatment on lens degeneration associated with in vivo exposure to cigarette smoke and to further clarify the role of iron in cigarette smoke-generated lens damage. METHODS: Twenty-eight male Wistar rats were randomly divided into four equal groups. Rats in groups 3 and 4 were exposed to cigarette smoke for 1 hour each day over 90 consecutive days, and rats in groups 1 and 2 were treated in similar fashion but only exposed to room air. Additionally, vitamin E was given to the rats in groups 2 and 4 via intramuscular route. At the end of the study, both eyes of all the animals were enucleated; one eye was prepared for histopathologic examination, and the fellow eye was used for the measurement of iron and calcium levels. RESULTS: Significantly higher iron and calcium levels were observed in the lenses of group 3 rats than in other groups. Similar comparisons performed between groups 1 and 2, groups 1 and 4, and groups 2 and 4 did not show any significant difference. Distinct histopathologic changes in the anterior lens epithelium, such as hyperplasia, hypertrophy, epithelial multilayering, and the presence of epithelial cells over posterior lens capsule, observed in group 3 rats were not present in other groups. CONCLUSIONS: Cataractogenesis after cigarette smoke exposure was associated with an accumulation of iron and calcium in the rat lens, and vitamin E supplementation protected such accumulations and cataractogenesis. PMID- 9950618 TI - Measurement of aqueous humor flow by fluorophotometry in the presence of a dilated pupil. AB - PURPOSE: To determine by means of fluorophotometry whether pharmacologic dilation of the pupil can interfere with the measurement of aqueous flow. METHODS: Ten normal human volunteers underwent dilation with tropicamide, phenylephrine, and a combination of the two drugs. Before and after dilation, the rate of aqueous flow was measured by the rate of disappearance of fluorescein from the cornea and the anterior chamber. RESULTS: Dilation of the pupil with tropicamide alone had no effect on the rate of clearance of fluorescein. Dilation with phenylephrine increased the rate of clearance of fluorescein by 40% and caused a small increase in the variability among subjects. Dilation with a combination of tropicamide and phenylephrine caused clearance of fluorescein at more than double the normal rate and a marked increase in variability among subjects. CONCLUSIONS: When the pupil is dilated sufficiently to permit mixing of aqueous humor in the posterior and anterior chambers, fluorescein can leave the system by a posterior route, and its rate of clearance may not be an accurate measure of the net rate of aqueous humor flow through the anterior chamber. PMID- 9950619 TI - Role of vertebral arteries hypoplasia in migraine. PMID- 9950620 TI - Further observations on postspinal headache. PMID- 9950621 TI - Differential effects of the 5HT1B/1D receptor agonist naratriptan on trigeminal versus spinal nociceptive responses. AB - In vivo electrophysiological assays in anesthetized rats have been used to compare the effects of the 5HT1B/1D receptor agonist, naratriptan, on central trigeminal nociceptive processing from dural and cutaneous inputs with its effects on nociceptive processing in the spinal cord. Naratriptan inhibited responses of single trigeminal neurons, to noxious electrical and mechanical stimulation of the dura and face, dose dependently by a maximum of 67+/-3% and 70+/-18%, respectively, at 3 mg kg(-1) i.v. In contrast, naratriptan did not affect spinal dorsal horn neuronal responses to noxious mechanical stimulation of the hind-paw. These findings suggest that 5HT1B/1D receptors have differential effects on nociceptive processing in the trigeminal versus spinal dorsal horns and provide a potential explanation for the lack of general analgesic effects of brain penetrant 5HT(1B/1D) agonist antimigraine drugs. PMID- 9950622 TI - Abnormal 24-hour urinary excretory pattern of 6-sulphatoxymelatonin in both phases of cluster headache. AB - The typical cyclic occurrence of cluster headache suggests the involvement of hypothalamic rhythm regulating centers in the pathogenesis of this primary headache. In previous studies, reduced 24-h plasma melatonin levels during the cluster period, loss of circadian melatonin secretion in remission, as well as permanently reduced excretion of urinary melatonin in both illness phases have been reported, supporting the hypothesis of a hypothalamic derangement. In this study, the 24-h urinary excretion of the main melatonin metabolite, 6 sulphatoxymelatonin, was evaluated in 20 cluster period cluster headache patients. Thirteen were retested 12 months later, in the same period of the year, during remission. Fourteen age- and sex-matched healthy subjects were the controls. As expected, significantly higher levels of 6-sulphatoxymelatonin were present in nocturnal urine than in day-time urine in controls, while in both cluster headache groups urinary levels of this metabolite did not differ between day and night. Nocturnal levels of 6-sulphatoxymelatonin were significantly lower in both cluster headache groups than controls. Day-time levels did not differ significantly between the groups. Altered excretion of urinary 6 sulphatoxymelatonin even during remission indicates that at least some of these anomalies are independent of the pain, and provides further evidence of involvement of the hypothalamic rhythm regulating centers in cluster headache. PMID- 9950623 TI - Combined evaluation of pupillary and cardiovascular responses to cold pressor test in cluster headache patients. AB - Little is known about the structures and mechanisms involved in the pathophysiology of cluster headache (CH). In this study, pupillary and cardiovascular responses to the cold pressor test (CPT) were monitored in CH patients during either an active phase of disease or a remission period in order to evaluate the oculocephalic and cardiovascular functioning of the autonomic nervous system in this form of idiopathic headache. CH patients showed a specific pattern of pupillary response on both sides during both phases of the disease. This response differed from that of controls because of an absent miosis. The pressor response to CPT was more marked in CH patients than in controls. Naloxone pretreatment caused specific and selective changes in both the pupillary and cardiovascular responses of CH patients. These data suggest a systemic sympathetic hyperactivation in response to CPT in CH patients. An oculocephalic sympathetic hypofunction is possibly associated as well as an altered opioid neuromodulation. PMID- 9950624 TI - Thermal sensitivity in unilateral headaches. AB - Thermal thresholds were measured in the face (first and second trigeminal area), over the mastoid process (C2-3 area), and in the hands in patients with migraine (n=17), cluster headache (n=22), and cervicogenic headache (n=20). Significant symptomatic versus nonsymptomatic side differences were generally not found for any headache group. Cluster headache patients had significantly higher warm thresholds than controls (n=24) for most of the cephalic points. Cervicogenic headache patients had significantly higher warm and cold thresholds than controls (n=56) at several cephalic and noncephalic points. Warm thresholds over the mastoid process on the symptomatic side were higher in cervicogenic headache patients compared to the other groups. In migraine patients, thermal thresholds were similar to those in controls. Thus, we found no evidence of focal or unilateral peripheral somatic nerve dysfunction involving C or A-delta fibers in any of the studied headache groups, although a C2-3 root dysfunction in cervicogenic headache could not be excluded. A bilateral central sensory dysfunction in cluster headache and cervicogenic headache may be hypothesized but a generalized peripheral dysfunction can also explain our results. PMID- 9950625 TI - Role of vertebral artery hypoplasia in migraine. AB - The role of cerebral hypoperfusion in the posterior circulation has not been clearly established in migraine. The purpose of this study was to determine the role of vertebral artery (VA) hypoplasia in the pathogenesis of migraine. We studied the extracranial part of VA in 59 migraine patients (17 with and 42 without aura) using color Doppler. In migraine with aura, 29% of patients had hypoplastic VA, and in migraine without aura 7%. In migraine with aura, mean diameter of the right VA was 2.7+/-0.7 mm, and of the left 3.3+/-0.7 mm; in migraine without aura mean diameter was 3.1+/-0.5 mm on the right, and 3.3+/-0.6 on the left. In migraine with aura, mean systolic blood flow velocity was 55+/-16 cm/s on the right, 60+/-17 cm/s on the left, in migraine without aura 57+/-18 cm/s on the right, 57+/-18 cm/s on the left. We observed higher frequency of hypoplastic VA in migraine with aura, suggesting that hypoplasia of VA may be an additional factor which can lead to hypoperfusion in the posterior circulation during the aura phase. PMID- 9950626 TI - Headache in hypothyroidism. Prevalence and outcome under thyroid hormone therapy. AB - OBJECTIVE: To evaluate the frequency of headache in patients with hypothyroidism. DESIGN: A prospective study of a cohort of patients with hypothyroidism. SETTING: Outpatients or inpatients in a headache clinic and endocrinological clinic. PATIENTS: 102 adults, ages 35 to 78 (83F, 19M) experiencing clinical and biological hypothyroidism. RESULTS: Thirty-one patients with hypothyroidism of 102 (30%) presented with headache 1 to 2 months after the first symptoms of hypothyroidism. The headache was slight, nonpulsatile, continuous, bilateral, and salicylate responsive and disappeared with thyroid hormone therapy. CONCLUSION: The authors believe there is a prevalence of nonspecific headache in hypothyroidism and that it has a particular response to thyroid hormone therapy. Hypothyroidism is another cephalalgia with an endocrinological cause after menstrual cephalalgia. We suspect a metabolic or vascular pathophysiological process. PMID- 9950627 TI - Migraine with aura: a review of 81 patients at 10-20 years' follow-up. AB - We investigated the evolution over time of migraine with aura (MA) in a number of MA patients consecutively referred to the University of Parma Headache Center in the period 1976-86. The follow-up period chosen for our review of the clinical condition of patients varied from a minimum of 10 years to a maximum of 20 years. The study group comprised 81 patients (55F, 26M), 21 of them (14.2%) with at least one parent with MA. Migraine without aura (MO) was also present in 29.6% of the patients studied. Currently, 35% of patients (29.4% F, 46.1% M) have been free from attacks for at least 1 year and 19.4% (13.6% F, 30.8% M) for over 5 years. Moreover, the frequency of attacks has decreased considerably in 54.4% of cases (50% F, 63.7% M); it has increased in only 25% (26.1% F, 22.7% M). The headache has disappeared completely in 11.1% of patients (8.0% F, 18.2% M); it has become less severe in 36.2% and more severe in only 5.5%. The results of our investigation point to a favorable evolution of MA over time. PMID- 9950628 TI - Pain location and associated symptoms in post-lumbar puncture headache. AB - In this prospective study of 239 patients, 88 (37%) suffered from post-lumbar puncture headache (PPH). The pain was located within the region innervated by the trigeminal nerve in 49% of the drawings, within the occipital and/or suboccipital region in 11%, and within the combined trigeminal/occipital region in 39%. The headache was unilateral at least once in 34% of the patients. Changes in pain location from one region to the other and/or between bilateral and unilateral headache were observed in 54% of the patients throughout the PPH period. Associated symptoms were experienced by 85%, nausea (73%) and dizziness (60%) being the most frequently reported. In the upright position, nausea, dizziness, and tinnitus tended to be present during a fairly large part of the PPH period (57-63% of the days), vomiting occurring only occasionally (28%). The intensity of associated symptoms was positively correlated to PPH severity. Pain in the combined trigeminal/occipital region was most severe and related to more associated symptoms than pain in other regions, and unilateral pain was milder than bilateral pain. Pain in the occipital and/or suboccipital region was mildest. The severity of nausea decreased significantly on the last 2 days of the PPH period, and the intensity of dizziness decreased when PPH was about to subside. Tinnitus is probably due to a cochlear dysfunction, and presents special characteristics. Its incidence was not clearly related to PPH severity and it increased with increasing duration of PPH; its intensity did not decline when PPH was about to wane. PMID- 9950629 TI - Feverfew as a preventive treatment for migraine: a systematic review. AB - BACKGROUND: Feverfew is a popular herbal remedy advocated for the prevention of migraine. AIM: The aim of this systematic review was to look at the evidence for or against the clinical effectiveness of feverfew in migraine prevention. DATA SOURCES: Literature searches were performed using the following databases: Medline, Embase, Biosis, CISCOM, and the Cochrane Library (all from their inception to April 1998). STUDY SELECTION: Only randomized, placebo-controlled, double-blind trials were included. DATA EXTRACTION: All articles were read by two independent reviewers. Data were extracted in a predefined, standardized fashion. The methodological quality of all trials was evaluated using the Jadad score. MAIN RESULTS: Five trials met the inclusion/exclusion criteria. The majority favor feverfew over placebo. Yet important caveats exist. CONCLUSION: The clinical effectiveness of feverfew in the prevention of migraine has not been established beyond reasonable doubt. PMID- 9950630 TI - Facial pain in a case of cranial dystonia: a case report. AB - A 76-year-old man had shown sustained excruciating facial pain in the maxillary region for more than 30 years. Since he was suffering from blepharospasm, facial electromyography was performed and revealed a perioral dystonia. This possible cause of facial pain might have been overlooked had dystonia not been considered and electromyographical studies performed. Repeated intramuscular perioral injections of botulinum toxin brought about complete pain relief. This case shows that involuntary activity of facial muscles can cause a severe chronic pain syndrome. Possible mechanisms include irritation of ascending trigeminal fibers, muscle ischemia due to compression of blood -vessels, or release of pain producing substances. PMID- 9950631 TI - Hypnic headache syndrome. Reply to Dr. Ravishankar. PMID- 9950632 TI - Use of infrared spectroscopy to assess secondary structure of human growth hormone within biodegradable microspheres. AB - The purpose of this study was to test the utility of infrared (IR) spectroscopy to determine protein secondary structure in biodegradable microspheres. Encapsulation of proteins within biodegradable polymers, [e.g. poly(lactic-co glycolic acid) (PLGA)] for controlled drug release has recently been the subject of intense research effort. The ability to assess protein integrity after microsphere production is necessary to successfully produce microspheres that release native proteins. We used IR spectroscopy, a noninvasive method-as opposed to conventional organic solvent extraction or in vitro release at elevated temperature-to assess the secondary structure of recombinant human growth hormone (rhGH) within dry and rehydrated microspheres. PLGA microspheres containing rhGH with different excipients were prepared by a conventional double-emulsion method. The protein IR spectra indicated that the encapsulation process could perturb the structure of rhGH and that excipients could inhibit this damage to varying degrees. A strong positive correlation was found between intensity of the dominant alpha-helical band in the spectra of rhGH in rehydrated microspheres and the percent monomer released from microspheres during incubation in buffer. We also studied microspheres prepared with zinc-precipitated rhGH. The addition of Zn2+ during microsphere processing partially inhibited protein unfolding and fostered complete refolding of rhGH upon rehydration. In conclusion, IR spectroscopy can serve as a valuable tool to assess protein structure within both dried and rehydrated microspheres. PMID- 9950633 TI - On the structural preservation of recombinant human growth hormone in a dried film of a synthetic biodegradable polymer. AB - In this work we describe the structural investigation of the model protein recombinant human growth hormone (rhGH) under conditions relevant to polymeric sustained-delivery depots, including the dried protein entrapped in a film of poly(DL-lactic-co-glycolic)acid. At each step of the procedure, dehydration of rhGH by lyophilization, suspension in methylene chloride, and drying from that suspension, the structure of rhGH was probed noninvasively using Fourier transform infrared (FTIR) spectroscopy. We found that the structure of rhGH was significantly changed by the dehydration process as indicated by a marked drop in the alpha-helix content and increase in the beta-sheet content. Subsequent suspension of this powder in methylene chloride, drying from that suspension, and drying from a methylene chloride/PLGA solution introduced only minor additional structural changes when using appropriate conditions. This result is likely due to the limited molecular mobility of proteins in nonprotein-dissolving organic solvents. Finally, when rhGH was co-lyophilized with the lyoprotectant trehalose, which preserves the secondary structure, the rhGH entrapped in the PLGA matrix also had a nativelike secondary structure. PMID- 9950634 TI - Pressure susceptibility of polymer tablets as a critical property: a modified Heckel equation. AB - The pressure susceptibility (chip), which is defined as the decrease of porosity (epsilon) under pressure was investigated. Of special interest are compacts obtained at very low pressures, because of the transition between the state of a powder and the state of a tablet. This range was found to be critical in respect to a diverging pressure susceptibility. Above a critical porosity (epsilonc) or below the corresponding relative density (rhoc), no pressure susceptibility can be defined, because of no rigid structure exists. To take this into account, a simple function was proposed for the pressure susceptibility: chip approximately 1/(epsilonc - epsilon). This proposal leads to a new porosity vs pressure relationship. The new model was compared to the Heckel equation that involves a constant pressure susceptibility. Various polymers were tested from "out of die" measurements, and the new relationship was found superior to the Heckel equation. As a conclusion, the pressure susceptibility exhibits a curvature that can be called critical at low relative densities. Consequently, a better understanding evolves as to why the Heckel equation is not valid at low pressures. The new model has proven to be adequate for polymer tablets but, so far it is not clear whether other substances exhibit the same performance. Especially tableting materials exhibiting brittle fracture will be of interest considering their importance in compaction technology. PMID- 9950635 TI - Permeability characteristics of novel mydriatic agents using an in vitro cell culture model that utilizes SIRC rabbit corneal cells. AB - The purpose of this study was to evaluate the permeability characteristics of a previously reported in vitro corneal model that utilizes SIRC rabbbit corneal cells and to investigate the permeability of three novel esters of phenylephrone chemical delivery systems (CDS) under different pH conditions using this in vitro model. The SIRC rabbit corneal cell line was grown on transwell polycarbonate membranes, and the barrier properties were assessed by measuring transepithelial electrical resistance (TEER) using a voltohmmeter. The permeabilities of esters of phenylephrone CDS across the SIRC cell layers were measured over a pH range 4.0-7. 4. The esters tested include phenylacetyl (1), isovaleryl (2), and pivalyl (3). The SIRC rabbit corneal cell line, when grown on permeable filters, formed tight monolayers of high electrical resistance with TEER values increasing from 71.6 +/- 20.8 Omega.cm2 at day 3 in culture to 2233.42 +/- 15.2 Omega.cm2 at day 8 in culture and remained constant through day 14 in culture. The transepithelial permeability coefficients (Papp) at pH 7.4 ranged from 0.58 x 10(-6) cm/s for the hydrophilic marker, mannitol, to 43. 5 x 10(-6) cm/s for the most lipophilic molecule, testosterone. The Papp at pH 7.4 for phenylephrine was 4.21 x 10(-6) cm/s. The Papp values and the lag times of the three esters of phenylephrone were pH dependent. The Papp for 1, 2, and 3 at pH 7.4 were 14.76 x 10(-6), 13.19 x 10( 6), and 12.86 x 10(-6) cm/s, respectively and the permeabilities decreased at conditions below pH 7.4. The lag times at pH 7.4 were 0.10, 0.17, and 0.12 h for 1, 2, and 3, respectively, and the values increased at lower pH conditions. The TEER values of SIRC cell line observed at day 8 to day 14 in the present investigation are similar to the resistance value reported for rabbit cornea (2 kOmega.cm2). All the esters showed significantly (p < 0.05) higher permeabilities than phenylephrine at pH 7.4. The rate and extent of transport of the drugs across the cell layers were influenced by the fraction of ionized and un-ionized species and the intrinsic partition coefficient of the drug. The results indicate that the permeability of ophthalmic drugs through ocular membranes may be predicted by measuring the permeability through the new in vitro cell culture model. PMID- 9950637 TI - Process control in a high shear mixer-granulator using wet mass consistency: the effect of formulation variables. AB - This work investigates the relationships between the wet mass consistency/viscosity of samples prepared in a mixer-granulator and physical properties of the dry granules produced from the wet mass; namely, size distribution, bulk density (Hausner ratio), friability, and flow avalanching behavior. The correlation between the consistency of the wet mass and the downstream dry granule properties confirms that consistency is the key parameter to control in wet granulation by mechanical agitation. Variations in the formulation affect the dimensionless power relationship of the mixer-granulator considered; that is, the equivalence between wet mass consistency and mixer net power consumption, which is actually the parameter used to monitor the wet granulation process. The same variations in formulation also affect the relationships between wet mass consistency and dry granule properties. PMID- 9950636 TI - Differences in the lipoprotein distribution of halofantrine are regulated by lipoprotein apolar lipid and protein concentration and lipid transfer protein I activity: in vitro studies in normolipidemic and dyslipidemic human plasmas. AB - The purpose of these studies was to determine the distribution of a lipophilic antimalarial agent, halofantrine hydrochloride (Hf), in fasted plasma from hypo-, normo-, and hyperlipidemic patients that displayed differences in lipoprotein concentration and lipid transfer protein I (LTP I) activity. To assess the influence of modified lipoprotein concentrations and LTP I activity on the plasma distribution of Hf, Hf at a concentration of 1000 ng/mL was incubated in either hypo-, normo-, or hyperlipidemic human plasma for 1 h at 37 degreesC. Following incubation, the plasma samples were separated into their lipoprotein and lipoprotein-deficient plasma (LPDP) fractions by density gradient ultracentrifugation and assayed for Hf by high-pressure liquid chromatography. The activity of LTP I in the dyslipidemic plasma samples was determined in terms of its ability to transfer cholesteryl ester from low-density lipoproteins (LDL) to high-density lipoproteins (HDL). Total plasma and lipoprotein cholesterol (esterified and unesterified), triglyceride, and protein levels in the dyslipidemic plasma samples were determined by enzymatic assays. When Hf was incubated in normolipidemic plasma for 1 h at 37 degreesC, the majority of drug was found in the LPDP fraction. When Hf was incubated in human plasma of varying total lipid, lipoprotein lipid, and protein concentrations and LTP I activity, the following relationships were observed. As the triglyceride-rich lipoprotein (TRL) lipid and protein concentration increased from hypolipidemia through to hyperlipidemia, the proportion of Hf associated with TRL increased (r > 0.90). As the HDL lipid and protein concentration increased, the proportion of Hf associated with HDL decreased (r > 0.70). As the total and lipoprotein lipid levels increased, the LTP I activity of the plasma also proportionally increased (r > 0.85). Furthermore, with the increase in LTP I activity, the proportion of Hf associated with the TRL fraction increased (r > 0.70) and the proportion of Hf associated with the HDL fraction decreased (r > 0.80). In addition, a positive correlation between the proportion of apolar lipid and Hf recovered within each lipoprotein fraction was observed within hypo- (r > 0.80), normo- (r = 0.70), and hyperlipidemic (r > 0.90) plasmas. These findings suggest that changes in the HDL and TRL lipid and protein concentrations, LTP I activity, and the proportion of apolar lipid within each lipoprotein fraction may influence the plasma lipoprotein distribution of Hf in dyslipidemia. PMID- 9950638 TI - Existence of a mannitol hydrate during freeze-drying and practical implications. AB - We report thermal and crystallographic evidence for a previously unknown mannitol hydrate that is formed in the process of freeze-drying. The mannitol hydrate was produced by freeze-drying pure mannitol solutions (1-4% w/v) using the following cycle: (1) equilibration at -5 degreesC for 1 h; (2) freezing at -40 degreesC; (3) primary drying at -10 degreesC for 15 h; and (4) secondary drying at 10 degreesC for 2 h and then 25 degreesC for 5 h. This crystal form was also observed upon freeze-drying in the presence of sorbitol (1% w/v). The mannitol hydrate showed a distinct X-ray powder diffraction pattern, low melting point, and steplike desolvation behavior that is characteristic of crystalline hydrates. The mannitol hydrate was found to be metastable, converting to anhydrous polymorphs of mannitol upon heating and exposure to moisture. The amount of the mannitol hydrate varied significantly from vial to vial, even within the same batch. The formation of mannitol hydrate has several potential consequences: (1) reduced drying rate; (2) redistribution of the residual hydrate water during accelerated storage to the amorphous drug; and (3) vial-to-vial variation of the moisture level. PMID- 9950639 TI - Stability and surface activity of lactate dehydrogenase in spray-dried trehalose. AB - The stability of the model protein lactate dehydrogenase (LDH) during spray drying and also on subsequent dry storage was examined. Trehalose was used as a carrier. The spray-drying temperatures Tinlet and Toutlet have a measurable effect on LDH inactivation. Low Tinlet produced the least process inactivation, but gave a high residual moisture content making the protein's storage stability poor. High Tinlet reduced residual moisture and improved storage stability, but at the cost of high process inactivation. As already found for other systems, addition of a surfactant (in this case polysorbate 80) could ameliorate process inactivation of LDH at Tinlet = 150 degreesC. Surfactant had, however, a deleterious effect on storage stability of LDH, the vital factor being the molar ratio of surfactant/protein in the dried product. By using electron spectroscopy it was shown that LDH has a 10 times higher surface concentration in the dried trehalose particles than expected for a homogeneous distribution. Surface tension measurements at the water/air interface proved that LDH is surface active, although the Gibbs equation appeared to be inapplicable. Calculations of spray droplet formation time and drying time indicate than the extent of diffusion driven LDH adsorption to the liquid/air interface is sufficient to account for the measured amount of LDH inactivation during spray-drying. The presence of 0.1% polysorbate 80 to the spray solution prevents LDH from appearing at the surface of the dried particles. As a negative control, the phosphatide Lipoid E 80 does not prevent the appearance of LDH in the surface according to electron spectroscopy and does not therefore prevent LDH inactivation during spray-drying at Tinlet = 150 degreesC. PMID- 9950640 TI - Inulin hydrogels as carriers for colonic drug targeting. Rheological characterization of the hydrogel formation and the hydrogel network. AB - Free radical polymerization converts aqueous solutions of methacrylated inulin into cross-linked hydrogels. The purpose of this work was to study the hydrogel formation and to characterize the fully cured hydrogels. The gelation process of aqueous solutions of methacrylated inulin was monitored as a function of time by means of linear oscillatory shear measurements, at a fixed frequency and amplitude. The fully cured inulin hydrogels were characterized by measurement of the frequency-dependency of the linear elastic modulus G'. The effects of the degree of substitution and feed concentration of methacrylated inulin on both the gelation kinetics and the rigidity of the obtained hydrogels were determined. The effect of the concentration of the initiators of the radical polymerization reaction has been studied as well. The weight fraction of polymer which was not incorporated in the hydrogel networks was determined using the anthrone reaction, and physical chain entanglements were determined by solution viscosity measurements. The gelation kinetics and the elastic modulus were proportional to the degree of substitution and feed concentration of methacrylated inulin. Increasing concentrations of radical-forming compounds also accelerated the hydrogel formation, but lowered the elastic modulus of the obtained hydrogels. The amount of polymer chains incorporated in the hydrogel network seemed to be especially influenced by the degree of substitution of the derivatized inulin, and for a feed concentration of 27% w/w of methacrylated inulin, entanglements have to be accounted for. The gelation kinetics and the elastic modulus of inulin hydrogels are not only affected by the degree of substitution and the feed concentration of methacrylated inulin, but also by the concentration of the initiators of the free radical polymerization reaction. PMID- 9950641 TI - Controlled release of human immunoglobulin G. 1. Release kinetics studies. AB - The release of human immunoglobulin G (IgG) using ethylene-vinyl acetate copolymer (EVAc) as a polymer carrier was studied by fabricating them into two commercially available dosage forms: slab and microsphere. A first-order flux decay model and two hierarchical models concerned with the mass transfer coefficient on the slab surface were used to describe the mechanism of release kinetics and the results compared. These models gave insight to some of the important physical parameters of drug release such as the diffusion coefficient, time constant of release, and initial flux. It was found that the release mechanism varies with time, and hence no single model can be used to predict the release profile for the entire period of study. A controlled release study by matrix coating was also done. The results obtained were utilized to examine the suitability of a particular dosage form (matrix geometry) of IgG for clinical applications. The release data compared with the standard methods of IgG therapy proves localized drug delivery to be a major boon for immunodeficient patients. PMID- 9950642 TI - Controlled release of human immunoglobulin G. 2. Morphological characterization. AB - Human immunoglobulin G (IgG) serves as an important chemotherapeutic agent for a number of immunological ailments and as a carrier in the targeted delivery of other therapeutic agents. This paper deals with the characterization of IgG dispersed monolithic matrixes of different geometries, prepared using a nonbiodegradable polymer carrier EVAc. The morphological changes associated with the matrix during drug release was studied using scanning electron microscopy, polarizing microscopy, atomic force microscopy, and X-ray photoelectron microscopy, and the results were compared. The study answered the burst effect problem significantly and illustrated the potential of these techniques in understanding the morphological structure of matrixes and mode of release kinetics. PMID- 9950643 TI - Prediction of partition coefficient based on atom-type electrotopological state indices. AB - The aim of this study was to determine the efficacy of atom-type electrotopological state indices for estimation of the octanol-water partition coefficient (log P) values in a set of 345 drug compounds or related complex chemical structures. Multilinear regression analysis and artificial neural networks were used to construct models based on molecular weights and atom-type electrotopological state indices. Both multilinear regression and artificial neural networks provide reliable log P estimations. For the same set of parameters, application of neural networks provided better prediction ability for training and test sets. The present study indicates that atom-type electrotopological state indices offer valuable parameters for fast evaluation of octanol-water partition coefficients that can be applied to screen large databases of chemical compounds, such as combinatorial libraries. PMID- 9950644 TI - Pharmacodynamic analysis of the electrocardiographic interaction between disopyramide and erythromycin in rats. AB - Disopyramide (DP) is known to induce QT prolongation and Torsades de Pointes (TdP) when administered concomitantly with erythromycin (EM). To define and evaluate quantitatively the arrhythmogenic risk of the concomitant administration of DP and EM, we investigated the influence of EM on the pharmacokinetics and pharmacodynamics of DP in rats. The time profiles of change in QT interval and plasma concentration of each drug were evaluated during and after constant intravenous infusion of DP (6.0 or 15.0 mg/kg/h), EM (4.0 or 8.0 mg/kg/h), and coadministration of DP and EM (DP 6.0 mg/kg/h plus EM 4.0 mg/kg/h). Each agent induced QT prolongation at plasma concentrations within the therapeutic range in humans. DP-induced QT prolongation was proportional to its plasma concentration. In the case of EM, the Emax model with an "effect compartment" could explain the relationship between plasma EM concentrations and changes in QT interval. Although coadministration of EM with DP gave enhanced QT prolongation compared to dosing with DP alone, EM did not affect the pharmacokinetics of DP. In conclusion, it was shown that a pharmacodynamic interaction contributes to the electrocardiographic adverse reaction (i.e., QT prolongation) induced by coadministration of DP and EM in rats. PMID- 9950645 TI - Hydrogen bonding. 47. Characterization of the ethylene glycol-heptane partition system: hydrogen bond acidity and basicity of peptides. AB - Twelve measured ethylene glycol-heptane partition coefficients, Peh, have been combined with 20 measured literature values and 44 indirectly determined values to give a set of 76 values. Excluding one value for benzamide, the log Peh values are correlated through our general solvation equation, log Peh = 0.336 - 0.075R2 1. 201pi2H - 3.786 Sigmaalpha2H - 2.201 Sigmabeta2H + 2.085Vx with r2 = 0.966, sd = 0.28, and F = 386. The solute descriptor R2 is the excess molar refraction, pi2H is the dipolarity/polarizability, Sigmaalpha2H and Sigmabeta2H are the overall hydrogen bond acidity and basicity, and Vx is the McGowan volume. The log Peh equation has then been used to obtain descriptors for eleven peptides, all of which are end-protected. It is shown that for these end-protected peptides, hydrogen bond basicity makes a greater contribution to log Peh than does hydrogen bond acidity. PMID- 9950646 TI - Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin. AB - We prepared two kinds of surface-coated liposomes and investigated their potencies as oral dosage forms for peptide drugs by focusing on their effects on the gastrointestinal (GI) transit of drugs. The surface of the liposomes was coated with poly(ethylene glycol) 2000 (PEG-Lip) or the sugar chain of mucin (Mucin-Lip). As a model peptide drug, insulin was encapsulated in these liposomes. Coating the surface with poly(ethylene glycol) was found to reduce the transit rate of liposomes in the small intestine after oral administration to rats in vivo. Mucin-Lip was retained in the stomach longer than PEG-Lip or uncoated liposomes. The effect of surface coating on the intestinal transit of liposomes was determined by means of in situ single pass perfusion in the rat small intestine. Statistical moment analysis was applied to the outflow pattern of both liposomes and encapsulated insulin. The mean transit time (MTT) and deviation of transit time (DTT) in the intestinal tract were calculated. The MTT of PEG-Lip was much longer than those of uncoated liposomes and Mucin-Lip and was significantly shortened after removal of the intestinal mucous layer. These results indicated that PEG-Lip interacts strongly with the intestinal mucous layer, leading to its slow transit in the intestine. In contrast, coating the liposome's surface with mucin did not affect either the MTT or DTT of liposomes in the intestine. This result is in accordance with the in vivo observation that Mucin-Lip was highly retained in the stomach, but not in any region of the small intestine in vivo. Both the MTT and DTT values of insulin encapsulated in PEG-Lip and Mucin-Lip were almost the same as those of liposomes themselves, suggesting that surface-coated liposomes retained insulin in the intestinal tract. However, MTT and DTT of insulin were significantly shorter than those of uncoated liposomes because these liposomes degraded and released significant amounts of insulin during single pass perfusion. The ability of surface-coated liposomes, especially of PEG-Lip, to interact with the mucus layer and slow the transit rate in the GI tract is considered desirable for oral delivery of peptide drugs. Modification of the liposomal surface with appropriate materials, therefore, should be an effective method by which to achieve the oral delivery of peptide drugs. PMID- 9950647 TI - Enhancement of paracellular drug transport with highly quaternized N-trimethyl chitosan chloride in neutral environments: in vitro evaluation in intestinal epithelial cells (Caco-2). AB - Previous studies have established that a partially quaternized derivative of chitosan, N-trimethyl chitosan chloride (TMC), can be used as an absorption enhancer for large hydrophilic compounds across mucosal surfaces. This study evaluates and compares the effects of the degree of quaternization of TMC, in a neutral environment, on the permeability of intestinal epithelial cells in vitro, where normal chitosan salts are ineffective as absorption enhancers. The effects of TMC-H [61.2% quaternized, (0.05-1.5% w/v)], TMC-L [12.3% quaternized, (0.5 1.5% w/v)], and chitosan hydrochloride [0.5-1.5% w/v] on the transepithelial electrical resistance (TEER) and permeability, for the hydrophilic model compound [14C]mannitol, of intestinal epithelial Caco-2 cell monolayers, were investigated at pH values of 6.20 and 7.40. The viability of the monolayers was checked with the trypan blue exclusion technique. At a pH of 6.20, all the polymers caused a pronounced reduction (37-67% at 0.5% w/v concentrations) in the TEER of Caco-2 cells. On the contrary, at a pH of 7.40, only TMC-H was able to decrease the TEER values, even in a concentration as low as 0.05% w/v (35% reduction). Comparable results were obtained with the permeation of [14C]mannitol. Large increases in the transport rate (18-23-fold at 0.5% w/v concentrations) were found at pH 6.20, whereas only TMC-H was able to increase the permeation of [14C]mannitol at pH 7.40 (31-48-fold at 0.05-1.5% w/v concentrations of TMC-H). For all the polymers studied, no deleterious effects to the cells could be demonstrated with the trypan blue exclusion technique. It is concluded that highly quaternized TMC is a potent absorption enhancer and the potential use of this polymer, especially in neutral and basic environments where normal chitosan salts are not effective, is expected to be an important contribution to the development of effective delivery systems for hydrophilic compounds such as peptide drugs. PMID- 9950648 TI - The versatility of polysorbate 80 (Tween 80) as an ionophore. AB - A number of experiments were performed to illustrate the unusual versatility of Polysorbate 80 (Tween 80) as an ionophore. New ions shown to be transported by it from and to water layers through a model membrane (CH2Cl2) include H3O+, Li+, Pb2+, Co2+, piperidinium ion, guanidinium ion, and Paraquat, while two complex ions resisted transport under the conditions used. "Reverse" transport of lipophilic guests (azobenzene, azulene, ferrocene) from and to organic solvents through water was also promoted by Tween 80, but C60 was not carried. Three water molecules were transported per molecule of KSCN by the Tween. PMID- 9950649 TI - Powder densification. 1. Particle-particle basis for incorporation of viscoelastic material properties. AB - The present investigation was undertaken to examine the basic unit of densification: the particle-particle indentation. The true interparticle contact area that is established during densification ultimately determines the quality of the tablet compact. By examining the interfacial contact between mutually indenting viscoelastic particles, the process of contact evolution may be represented in mathematical form through extension of the classical Hertzian elastic contact description to encompass material viscoelastic terms. In this way, the time-dependent response of materials to applied loads may be addressed explicitly. The effects of rates of applied loading and maximum load levels were also considered. This analysis was based on viscoelastic stress data collected using an instrumented Instron analyzer during the densification of PMMA/coMMA, a pharmaceutical polymeric coating material. A crossed cylinder matrix compaction geometry was used to simulate the geometry of two mutually indenting spherical particles. Numerical and graphical solutions delineating the relationship between contact area evolution and the prescribed loading force are presented. This particle-particle description of the contacting interface serves as a unit basis for describing the entire powder bed. The powder bed may ultimately be modeled as a collection of these particles in contact. PMID- 9950650 TI - Dose-dependent plasma clearance of MK-826, a carbapenem antibiotic, arising from concentration-dependent plasma protein binding in rats and monkeys. AB - After intravenous administration of MK-826, a new carbapenem antibiotic, the compound exhibited nonlinear pharmacokinetics in rats and monkeys. In both species, time-averaged plasma clearance (based on total concentrations) increased about 5-fold over the 10- to 180-mg/kg dose range. MK-826 was extensively plasma protein bound in rat and monkey plasma, and the extent of binding was concentration dependent at plasma concentrations achieved after administration of these doses. Rosenthal analysis of the plasma protein binding indicated that there were two classes of binding sites. The binding capacity of the primary site was comparable to the plasma albumin concentration, which suggested that this primary site consisted of a single site on albumin. The extent of binding of MK 826 to rat albumin was similar to that in whole plasma. Clearance values based on unbound concentrations appeared independent of dose from 10 to 180 mg/kg, which is consistent with saturation of protein binding as the primary cause of the nonlinear pharmacokinetic behavior. PMID- 9950652 TI - Dynamic holographic imaging of the beating human heart : february 9, 1999 PMID- 9950651 TI - Dynamic holographic imaging of the beating human heart AB - Background--Currently, the reporting and archiving of echocardiographic data suffer from the difficulty of representing heart motion on printable 2 dimensional (2D) media. Methods and Results--We studied the capability of holography to integrate motion into 2D echocardiographic prints. Images of normal human hearts and of a variety of mitral valve function abnormalities (mitral valve prolapse, systolic anterior motion of the mitral leaflets, and obstruction of the mitral valve by a myxoma) were acquired digitally on standard echocardiographic machines. Images were processed into a data format suitable for holographic printing. Angularly multiplexed holograms were then printed on a prototype holographic "laser" printer, with integration of time in vertical parallax, so that heart motion became visible when the hologram was tilted up and down. The resulting holograms displayed the anatomy with the same resolution as the original acquisition and allowed detailed study of valve motion with side-by side comparison of normal and abnormal findings. Comparison of standard echocardiographic measurements in original echo frames and corresponding hologram views showed an excellent correlation of both methods (P<0.0001, r2=0.979, mean bias=2.76 mm). In this feasibility study, both 2D and 3D holographic images were produced. The equipment needed to view these holograms consists of only a simple point-light source. Conclusions--Holographic representation of myocardial and valve motion from echocardiographic data is feasible and allows the printing on a 2D medium of the complete heart cycle. Combined with the recent development of online holographic printing, this novel technique has the potential to improve reporting, visualization, and archiving of echocardiographic imaging. PMID- 9950653 TI - Studying populations and heart disease risk. PMID- 9950654 TI - Function of the cardiac myocyte in the conundrum of end-stage, dilated human heart failure. PMID- 9950655 TI - NPR-A-Deficient mice show increased susceptibility to hypoxia-induced pulmonary hypertension. AB - BACKGROUND: Mice in which the gene encoding NPR-A, a guanylyl cyclase-linked natriuretic peptide receptor, has been disrupted were used to examine the contribution of natriuretic peptides to maintaining pulmonary vascular homeostasis in normal- and low-oxygen environments. METHODS AND RESULTS: Wild type (+/+), heterozygous (+/-), and homozygous null mutants (-/-) were studied. The response of the pulmonary vasculature to atrial, B-type, and C-type natriuretic peptides (ANP, BNP, and CNP) during acute hypoxia was studied in isolated perfused lungs. Right ventricular systolic pressure (RVSP), RV weight, and pulmonary vascular remodeling were measured in each genotype exposed to normal air and after 7 and 21 days in a hypoxic atmosphere (10% O2). ANP and BNP (300 ng) reduced pulmonary artery pressure during acute hypoxia-induced pulmonary vasoconstriction in +/+ mice, but this effect was attenuated in +/- and absent in -/- mice. CNP (600 ng) had little effect in all 3 genotypes. RVSP and RV weight were similar in the 3 genotypes housed in a normal-O2 environment. Seven and 21 days of hypoxia produced a pronounced and significantly greater increase in RVSP and RV weight in -/- mice compared with +/+ or +/- mice and more rapid muscularization of distal pulmonary arterioles. CONCLUSIONS: ANP and BNP do not contribute to maintaining normal pulmonary artery pressure but play an important role in attenuating the pulmonary vascular response to hypoxia. NPR-A mediates the vasorelaxant effect of ANP in pulmonary vasculature. PMID- 9950656 TI - Enhanced shear-induced platelet aggregation in acute myocardial infarction. AB - BACKGROUND: Experiments under controlled flow conditions indicate that the binding of von Willebrand factor (vWF) to platelet glycoprotein (GP) Ibalpha and integrin alphaIIbbeta3 (GP IIb/IIIa complex) is crucial for aggregation at elevated shear rates. We have tested how the plasma of patients with acute myocardial infarction affects this process. METHODS AND RESULTS: Citrated plasma was obtained from 18 patients with acute myocardial infarction within 6 hours from the onset of symptoms and from 26 control subjects with chest pain syndrome without evidence of ischemia. Aggregation of normal platelets at high shear rates was significantly greater in the presence of patient than control plasma and was inhibited by both anti-GP Ibalpha and anti-alphaIIbbeta3 monoclonal antibodies. The observed values (mean+/-SD) were 47.6+/-17.8% versus 30.1+/-9.9% at 10 800 s 1 (P<0.01) and 32.9+/-14.1% versus 17.5+/-9.5% at 7200 s-1 (P<0.01), respectively, and were positively correlated with plasma vWF antigen levels and ristocetin cofactor activities. In contrast, at the lower shear rate of 1200 s-1, aggregation was similar in the presence of control or patient plasma and was not inhibited by the anti-GP Ibalpha antibody. Both vWF antigen and platelet aggregation decreased 2 weeks after the onset of myocardial infarction. CONCLUSIONS: Shear-induced platelet aggregation is enhanced in plasma in the presence of acute myocardial infarction, apparently as a result of increased vWF concentration. This may contribute to the onset of acute coronary artery thrombosis and early reocclusion after reperfusion treatment. PMID- 9950657 TI - Poor response to activated protein C as a prominent risk predictor of advanced atherosclerosis and arterial disease. AB - BACKGROUND: The potential role of activated protein C (APC) resistance in arterial thrombosis and disease is a matter of ongoing controversy. METHODS AND RESULTS: In the present population-based survey, a random sample of 826 men and women underwent high-resolution duplex ultrasound scanning of the carotid and femoral arteries. Response to APC was expressed in APC ratios. Subjects were tested for the factor V Leiden mutation. The risk of carotid stenosis increased gradually with decreasing response to APC (adjusted OR [95% CI] for a 1-U decrease of response to APC, 1.6 [1. 2 to 2.2]), as did the risk of femoral artery stenosis (1.7 [1.3 to 2.3]) and prevalent cardiovascular disease (1.4 [1.1 to 2.0]). The association between low APC ratio and atherosclerotic vascular disease applied equally to subjects with the factor V Leiden mutation and those without. Our study identified various nongenetic determinants of poor response to APC in the general population, including behavioral, hormonal, and environmental factors. CONCLUSIONS: The present study revealed an independent and gradual association between low response to APC and both advanced atherosclerosis (stenosis) and arterial disease. Resistance to APC due to factor V Leiden mutation was only one facet of this relationship. PMID- 9950658 TI - Rapid platelet-function assay: an automated and quantitative cartridge-based method. AB - BACKGROUND: The platelet glycoprotein (GP) IIb/IIIa receptor is important in mediating platelet thrombus formation, and the GP IIb/IIIa antagonist abciximab (c7E3 Fab; ReoPro) is effective in preventing thrombotic ischemic cardiovascular complications of unstable angina and percutaneous coronary interventions. Small molecule antagonists of GP IIb/IIIa based on the Arg-Gly-Asp (RGD) sequence show similar benefit, and some of these agents are orally active. However, there may be significant interindividual variation in response to such antagonists, especially with chronic oral therapy. It will be essential to balance the beneficial antithrombotic effect of these drugs with their potential for causing bleeding. In response to this need, we have developed a rapid platelet-function assay (RPFA), a point-of-care system that provides a quantitative measure of the competence of the GP IIb/IIIa receptor as reflected in the ability of platelets to agglutinate fibrinogen-coated beads. METHODS AND RESULTS: Polystyrene beads were coated with fibrinogen and placed in a cartridge along with a lyophilized peptide that activates the thrombin receptor. Anticoagulated whole blood was added to the cartridge, and then a microprocessor-controlled operation mixed the reagents and detected agglutination between platelets and coated beads. Quantitative digital results were displayed within 3 minutes. Because there is no dilution of the blood, the assay can be used to measure platelet activity in samples that have been treated with GP IIb/IIIa antagonists with high dissociation rates. RPFA results of whole-blood samples treated with different GP IIb/IIIa antagonists correlated well with both conventional turbidimetric platelet aggregation (r2=0.95) and the percentage of free GP IIb/IIIa molecules in the sample (r2=0.96). The mean difference in measurements between RPFA and aggregometry was -4% (+/-4% SD), and the mean difference in measurements between RPFA and free GP IIb/IIIa receptors was -2% (+/-6% SD). CONCLUSIONS: The RPFA provides rapid information on platelet function that mirrors turbidimetric platelet aggregation and reflects GP IIb/IIIa receptor blockade. PMID- 9950659 TI - Heterogeneity of coronary flow reserve in the examination of multiple individual allograft coronary arteries. AB - BACKGROUND: Epicardial and resistance vessel function in the transplanted heart has been evaluated primarily in regions supplied by a single vessel. Heterogeneity of flow among multiple perfusion fields as a marker of early endothelial dysfunction in the microcirculation has not been evaluated previously. This study tested the hypothesis that increased variability of coronary flow reserve (CFR) among multiple vascular regions would be associated with allograft coronary vasculopathy. METHODS AND RESULTS: One hundred six posttransplant patients undergoing cardiac catheterization had measurement of CFR in at least 3 major epicardial vessels. Patients were divided into those with minimal angiographic abnormalities (n=37) and those with no angiographic abnormalities (n=69). The ranges, coefficients of variation, and univariate and multivariate regression analyses of CFR were computed to determine the major clinical factors influencing the degree of variability. The abnormal angiographic group was older (54+/-11 versus 47+/-13 years; P<0.003), had older hearts (35+/ 11 versus 27+/-10 years; P<0.005), and were further posttransplant (1626+/-1022 versus 931+/-984 days; P<0.0009). There was no difference in global CFR between groups (normal, 3.4+/-0.8 versus abnormal, 3.4+/-0.7; P=NS). The coefficient of variation of CFR was higher for the abnormal group (16.3+/-8.6% versus 11.0+/ 5.5%; P<0. 0006). Univariate and multivariate predictors of increased variability in CFR included angiographic abnormalities, patient age, and body mass index. Both angiographic abnormalities and an elevated CV of CFR were predictive of a combined end point of death, congestive heart failure, or subsequent development of >/=50% coronary stenosis. CONCLUSIONS: These data demonstrate that increased variability of CFR is associated with discernible allograft coronary arteriopathy and is predictive of outcome in patients after heart transplantation. PMID- 9950660 TI - Coronary revascularization in diabetic patients: a comparison of the randomized and observational components of the Aypass Angioplasty Revascularization Investigation (BARI). AB - BACKGROUND: Patients with treated diabetes in the randomized-trial segment of the Bypass Angioplasty Revascularization Investigation (BARI) who were randomized to initial revascularization with PTCA had significantly worse 5-year survival than patients assigned to CABG. This treatment difference was not seen among diabetic patients eligible for BARI who opted to select their mode of revascularization. We hypothesized that differences in patient characteristics, assessed and unmeasured, together with the treatment selection in the registry, at least partially account for this discrepancy. METHODS AND RESULTS: Among diabetics taking insulin or oral hypoglycemic drugs at entry, angiographic and clinical presentations were comparable between randomized and registry patients. However, more registry patients were white, and registry diabetics tended to be more educated and more physically active and to report better quality of life. Procedural characteristics and in-hospital complications were comparable. The 5 year all-cause mortality rate was 34.5% in randomized diabetic patients assigned to PTCA versus 19.4% in CABG patients (P=0.0024; relative risk [RR]=1.87); corresponding cardiac mortality rates were 23.4% and 8.2%, respectively (P=0.0002; RR=3.10). The CABG benefit was more apparent among patients requiring insulin. In the registry, all-cause mortality was 14.4% for PTCA versus 14.9% for CABG (P=0.86, RR=1.10), with corresponding cardiac mortality rates of 7.5% and 6. 0%, respectively (P=0.73; RR=1.07). These RRs in the registry increased to 1.29 and 1.41, respectively, after adjustment for all known differences between treatment groups. CONCLUSIONS: BARI registry results are not inconsistent with the finding in the randomized trial that initial CABG is associated with better long-term survival than PTCA in treated diabetic patients with multivessel coronary disease suitable for either surgical or catheter-based revascularization. PMID- 9950661 TI - Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium. AB - BACKGROUND: In the failing human heart, sarcoplasmic reticulum (SR) calcium handling is impaired, and therefore, calcium elimination and diastolic function may depend on the expression of sarcolemmal Na+-Ca2+ exchanger. METHODS AND RESULTS: Force-frequency relations were studied in ventricular muscle strip preparations from failing human hearts (n=29). Protein levels of Na+-Ca2+ exchanger and SR Ca2+-ATPase were measured in the same hearts. Hearts were divided into 3 groups by discriminant analysis according to the behavior of diastolic function when stimulation rate of muscle strips was increased from 30 to 180 min-1. At 180 compared with 30 min-1, diastolic force was increased by 160%, maximum rate of force decline was decreased by 46%, and relaxation time was unchanged in group III. In contrast, in group I, diastolic force and maximum rate of force decline did not change, and relaxation time decreased by 20%. Na+-Ca2+ exchanger was 66% higher in group I than in group III. Na+-Ca2+ exchanger was inversely correlated with the frequency-dependent rise of diastolic force when stimulation rate was increased (r=-0.74; P<0.001). Compared with nonfailing human hearts (n=6), SR Ca2+-ATPase was decreased and Na+-Ca2+ exchanger unchanged in group III, whereas Na+-Ca2+ exchanger was increased and SR Ca2+-ATPase unchanged in group I. Results with group II hearts were between those of group I and group III hearts. CONCLUSIONS: By discriminating failing human hearts according to their diastolic function, we identified different phenotypes. Disturbed diastolic function occurs in hearts with decreased SR Ca2+-ATPase and unchanged Na+-Ca2+ exchanger, whereas increased expression of the Na+-Ca2+ exchanger is associated with preserved diastolic function. PMID- 9950662 TI - Autoantibodies activating human beta1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure. AB - BACKGROUND: Autoantibodies against synthetic peptides of beta-adrenergic receptors have been observed in human cardiomyopathy. However, it has never been shown that such antibodies really interact with native human beta-adrenergic receptors, nor has the clinical impact of such an interaction been investigated in larger groups of patients. METHODS AND RESULTS: We screened 104 patients with dilated or ischemic cardiomyopathy (NYHA functional classes II to IV) and 108 healthy subjects for IgG antibodies reacting with beta-receptor peptides. Such IgGs were further analyzed for binding and functional interactions with native recombinant human beta-adrenergic receptors. Antibodies reacting with synthetic receptor peptides were present in 51% of the patients. However, only a subgroup directed against the second extracellular receptor domain also recognized native human beta-adrenergic receptors situated in a cell membrane. All antibodies of this subgroup impaired receptor ligand binding and enhanced receptor-mediated signaling, which could be blocked by 5 micromol/L bisoprolol in vitro. Their prevalence was 1% in healthy subjects and 10% in ischemic cardiomyopathy, whereas it amounted to 26% in dilated cardiomyopathy and was associated with a significantly poorer left ventricular function. CONCLUSIONS: Our data show that activating autoantibodies against human beta-adrenergic receptors exist in approximately 25% of patients with dilated cardiomyopathy. Counteraction of such autoantibodies might contribute to the beneficial effects of beta-adrenergic receptor blockade in chronic heart failure. PMID- 9950663 TI - First redo heart valve replacement: a 10-year analysis. AB - BACKGROUND: The United Kingdom Heart Valve Registry (UKHVR) has recently completed collecting information on 52 659 heart valve replacements (in 47 718 patients) performed during the period 1986 to 1995 in the whole of the United Kingdom. Information stored in the UKHVR's computer database was used for this study. Factors affecting the time from first prosthesis to first redo prosthesis were analyzed and provided useful predictive information. The association between prosthesis-induced local pathological processes and redo valve size was investigated. METHODS AND RESULTS: This is a retrospective study of 43 301 patients (from among 47 718 in the database) undergoing single-site replacement of a diseased native mitral or aortic valve over a 10-year period from January 1986 to December 1995 in the United Kingdom. Of these patients, 1051 (2.43%) went on to have a first redo heart valve replacement. Valve survival analysis (Cox regression and Kaplan-Meier curves) was used to study the natural progression to the first redo heart valve replacement. Female sex and having a replacement at the aortic rather than the mitral position were both associated with a longer interval to the first redo operation. Regression analysis showed the size of the redo valve to be influenced by the interoperative time. This effect was more pronounced at the mitral position. CONCLUSIONS: Females and patients having an aortic valve replacement exhibit a longer interval to the first redo operation than do males and patients having mitral valve replacements, respectively. The time from the first replacement to the first redo operation significantly affects the size of the first redo valve. PMID- 9950664 TI - Characterization of atrioventricular nodal reentry with continuous atrioventricular node conduction curve by double atrial extrastimulation. AB - BACKGROUND: Characterization of typical atrioventricular nodal reentrant tachycardia (AVNRT) with continuous AVN conduction (A1A2/A2H2) curves by double atrial extrastimulation (A1A2A3) has never been systematically studied. METHODS AND RESULTS: This study was composed of 33 patients with typical AVNRT and continuous AVN conduction curves (group 1) and 103 patients with AVNRT and discontinuous AVN conduction curves (group 2). Using A1A2A3 with predefined fast pathway-conducted A2, we examined the effects of slow pathway ablation on the A2A3/A3H3 curves in both groups. In group 1, anterograde AVN effective refractory period (272+/-33 versus 277+/-47 ms, P>0.05) and AVN Wenckebach block cycle length (320+/-45 versus 343+/-59 ms, P>0.05) remained unchanged after ablation. A2H2max was shorter in group 1 than group 2 (237+/-89 versus 395+/-72 ms, P<0.05) at baseline. It shortened in group 2 (395+/-72 versus 221+/-78 ms, P<0.001) but remained unchanged in group 1 (237+/-89 versus 214+/-59 ms, P>0.05) after ablation. A1A2A3 could further disclose discontinuous A2A3/A3H3 curves in 29 patients of group 1. A3H3max shortened in both groups (375+/-81 versus 238+/-82 ms, P<0.001, and 419+/-104 versus 220+/-78 ms, P<0.001, respectively) in a similar fashion. Successful ablation resulted in loss of the left portion of the A2A3/A3H3 curves in the 4 patients of group 1 with continuous A2A3/A3H3 curves. CONCLUSIONS: Use of A1A2A3 could expose discontinuous A2A3/A3H3 curves in most patients with continuous A1A2/A2H2 curves. Significant shortening of A3H3max after ablation may be indicative of successful elimination of AVNRT. PMID- 9950665 TI - "Brugada" syndrome: clinical data and suggested pathophysiological mechanism. PMID- 9950666 TI - Genetic and molecular basis of cardiac arrhythmias: impact on clinical management part III. PMID- 9950667 TI - Vasoflux, a new anticoagulant with a novel mechanism of action. AB - BACKGROUND: Heparin and direct thrombin inhibitors, such as hirudin, have limitations in the treatment of acute coronary syndromes. Heparin does not inactivate fibrin-bound thrombin, whereas hirudin fails to block thrombin generation. In contrast, Vasoflux is a novel anticoagulant that inactivates fibrin-bound thrombin and attenuates factor Xa generation. METHODS AND RESULTS: Vasoflux is prepared by depolymerization of heparin, restricting molecular size to between 3000 and 8000 Da, and reducing antithrombin affinity by periodate oxidation. Vasoflux catalyzes fibrin-bound thrombin inactivation by heparin cofactor II (HCII) and inhibits factor IXa activation of factor X independently of antithrombin and HCII. Compared with other anticoagulants in a thrombogenic extracorporeal circuit, Vasoflux maintains filter patency at concentrations that produce an activated clotting time (ACT) of 220 seconds. In contrast, to maintain filter patency, heparin, low-molecular-weight heparin (LMWH), and hirudin require concentrations that produced an ACT of 720, 415, and >1500 seconds, respectively, whereas dermatan sulfate was ineffective at concentrations that produced an ACT of 360 seconds. CONCLUSIONS: Vasoflux is more effective than heparin and LMWH because it inactivates fibrin-bound thrombin and is superior to hirudin and dermatan sulfate because it also blocks factor Xa generation. PMID- 9950668 TI - Noninvasive measurements of infarct size after thrombolysis with a necrosis-avid MRI contrast agent. AB - BACKGROUND: Gadophrin-2 is a new MRI contrast agent with high affinity for necrotic myocardium. The aim of the study was to evaluate whether noninvasive measurements of infarct size after thrombolysis are possible with gadophrin-2 enhanced MRI. METHODS AND RESULTS: Coronary artery thrombosis was induced in 3 groups of dogs by the copper-coil technique. Thrombolytic therapy together with aspirin and heparin was initiated after 90 minutes of occlusion. One day (group A), 2 days (group B), or 6 days (group C) after infarction, gadophrin-2 was injected intravenously (50 micromol. kg-1). In vivo T1-weighted segmented turbo FLASH, in vivo T2-weighted segmented half-Fourier turbo spin echo (HASTE), and T1 and T2-weighted spin-echo MRI of the excised heart were performed 24 hours after gadophrin-2 injection. Regions of strong enhancement were observed on T1-weighted images. Planimetry of short-axis MR images and of corresponding triphenyltetrazolium chloride (TTC)-stained left ventricular (LV) slices showed a close correlation between the enhanced areas and TTC-negative areas for both in vivo (r2=0.98, P<0.0001; mean difference, 0.9+/-2.0% [SD] of the LV volume [LVV]) and postmortem (r2=0.99, P<0.0001; mean difference, 0.9+/-1.4% of LVV) measurements. T2-weighted images overestimated the infarct size by 8.1+/-5.4% of LVV. The mean infarct size was 10.8+/-11.6% of LVV (group A), 22.4+/-11.7% (group B), and 5.1+/-9.3% (group C). CONCLUSIONS: In this animal model, in vivo gadophrin-2-enhanced MRI could precisely determine infarct size after thrombolytic therapy. This technique may be very useful for the noninvasive evaluation of infarct size after reperfusion for AMI. PMID- 9950669 TI - Chimeric DNA-RNA hammerhead ribozyme to proliferating cell nuclear antigen reduces stent-induced stenosis in a porcine coronary model. AB - BACKGROUND: Stent-induced coronary restenosis is a major clinical and public health problem. Proliferating cell nuclear antigen (PCNA) is an important regulator of cell division, and blocking of its expression after angioplasty may limit intimal proliferation. METHODS AND RESULTS: We cloned the porcine PCNA gene and constructed a chimeric hammerhead ribozyme to a segment of the gene with human homology. In vitro studies with both cultured porcine and human vascular smooth muscle cells demonstrated uptake of ribozyme within the nucleus and significant inhibition of cellular proliferation. The ribozyme was then delivered locally into pig coronaries in a stent model. At 30 days, histomorphometric analysis showed neointimal thickness of 0.51+/-0.20 mm in the ribozyme group versus 0.71+/-0.27 and 0.66+/-0.25 mm in stent controls and scrambled ribozyme control, respectively (P=0.002, P=0.03). Quantitative angiographic analysis showed late loss of 1.4+/-0.5 mm for ribozyme versus 1.9+/-0.4 and 2.0+/-0.4 mm for the controls (P=0.05 and P=0. 02). CONCLUSIONS: Chimeric hammerhead ribozyme to PCNA inhibits smooth muscle cell proliferation in vitro and reduces both histomorphometric and angiographic restenosis in the porcine coronary stent model when delivered locally. PMID- 9950671 TI - Clenbuterol increases stroke power and contractile speed of skeletal muscle for cardiac assist. AB - BACKGROUND: Skeletal muscle assist (SMA) may be limited by loss of power, slowing of contraction and relaxation, and atrophy of the transformed latissimus dorsi muscle (LD). Clenbuterol (clen), a beta2-adrenergic receptor agonist, was used to improve the performance of trained skeletal muscle in sheep. METHODS AND RESULTS: The following 4 groups were used: A (n=6), untrained controls; B (n=6), left LD progressively transformed toward a slow-twitch and fatigue-resistant phenotype by electrical stimulation over 12 weeks (2.5 to 5 V, 240- microsec pulse duration, 35 Hz, 3 to 6 pulses per burst, and up to 40 bursts per minute); C (n=6), clen treated (0.5 mg/kg SC) for 12 weeks; and D (n=6), clen+trained. In a terminal experiment, the mobilized LD was wrapped around a rubber aorta of a mock circulation and stimulated to contract 40 times per minute. Group A had an initial mean pressure augmentation (DeltaP) of 24.6 mm Hg and stroke power of 2.28 W/kg, but both fell to <20% of their original values by 15 minutes because of fatigue (P<0.005). Group B was fatigue-resistant, with a DeltaP and stroke power at 60 minutes of 13 mm Hg (70% of initial) and 0.34 W/kg (39% of initial), respectively. The performance of group C was similar to that of controls. In group D, however, the muscles were stronger at all time points than in B, with a DeltaP of 23 mm Hg and stroke power of 2.66 W/kg at 60 minutes (P<0.01). The speeds of contraction (+dP/dt:DeltaP) and relaxation (-dP/dt:DeltaP) were significantly greater in group D than B. Protein analyses showed group D to have only a trend toward greater abundance of the fast isoforms of myosin heavy chain and sarcoplasmic reticulum Ca2+-ATPase (P>0.1). CONCLUSIOINS: ++Clen improves the performance of trained skeletal muscle in a model of aortomyoplasty by unknown mechanisms. These findings may have important implications in SMA. PMID- 9950670 TI - Mechanism of acceleration of functional reentry in the ventricle: effects of ATP sensitive potassium channel opener. AB - BACKGROUND: The effect of effective refractory period (ERP) shortening on the vulnerability and characteristics of induced functional reentry in the ventricle remain poorly defined. We hypothesized that ERP shortening increases ventricular vulnerability to reentry and accelerates its rate, as is the case in the atrium. METHODS AND RESULTS: The epicardial surfaces of 19 isolated and superfused canine right ventricular slices (4x4 cm and <2 mm thick) were mapped with 480 bipolar electrodes 1.6 mm apart. Vulnerability was tested during pacing at a cycle length (CL) of 600 ms and with a single premature stimulus of 5-ms duration at increasing current strength of 1 to 100 mA. Cromakalim (10 micromol/L), an ATP sensitive potassium channel opener, caused a significant (P<0. 001) shortening of the ERP but had no effect on conduction velocity. Cromakalim increased (P<0.01) the vulnerability (product of current and the stimulus coupling interval) for reentry induction. Reentry had a significantly shorter CL and lasted for a longer duration (P<0. 001). The central core around which the wave front rotated became smaller, which caused shortening of the CL of reentry. A significant (P<0.001) linear correlation was found between core size and reentry CL. These effects of cromakalim were reversible. Two-dimensional simulation studies using the modified Luo-Rudy I model of cardiac action potential, in which the refractory period was variably shortened by a progressive increase of the time-independent potassium conductance, reproduced the experimental findings. CONCLUSIONS: ERP shortening by an ATP-sensitive potassium channel opener increases ventricular vulnerability to reentry and accelerates its rate by decreasing the core size around which the wave front rotates. PMID- 9950673 TI - Sudden cardiac death, RBBB, and right precordial ST-segment elevation. PMID- 9950672 TI - Spontaneous postpartum coronary dissection. PMID- 9950674 TI - Liz1p, a novel fission yeast membrane protein, is required for normal cell division when ribonucleotide reductase is inhibited. AB - Ribonucleotide reductase activity is required for generating deoxyribonucleotides for DNA replication. Schizosaccharomyces pombe cells lacking ribonucleotide reductase activity arrest during S phase of the cell cycle. In a screen for hydroxyurea-sensitive mutants in S. pombe, we have identified a gene, liz1(+), which when mutated reveals an additional, previously undescribed role for ribonucleotide reductase activity during mitosis. Inactivation of ribonucleotide reductase, by either hydroxyurea or a cdc22-M45 mutation, causes liz1(-) cells in G2 to undergo an aberrant mitosis, resulting in chromosome missegregation and late mitotic arrest. liz1(+) encodes a 514-amino acid protein with strong similarity to a family of transmembrane transporters, and localizes to the plasma membrane of the cell. These results reveal an unexpected G2/M function of ribonucleotide reductase and establish that defects in a transmembrane protein can affect cell cycle progression. PMID- 9950675 TI - A cell signal pathway involving laminin-5, alpha3beta1 integrin, and mitogen activated protein kinase can regulate epithelial cell proliferation. AB - Laminin-5 (LN5) is a matrix component of epithelial tissue basement membranes and plays an important role in the initiation and maintenance of epithelial cell anchorage to the underlying connective tissue. Here we show that two distinct LN5 function-inhibitory antibodies, both of which bind the globular domain of the alpha3 subunit, inhibit proliferation of epithelial cells. These same antibodies also induce a decrease in mitogen-activated protein kinase activity. Inhibition of proliferation by the function-perturbing LN5 antibodies is reversed upon removal of the antibodies and can be overcome by providing the antibody-treated cells with exogenous LN5 and rat tail collagen. Because epithelial cells use the integrin receptor alpha3beta1 to interact with both LN5 and rat tail collagen, we next investigated the possibility that integrin alpha3beta1 is involved in mediating the proliferative impact of LN5. Proliferation of human epithelial cells is significantly inhibited by a function-perturbing alpha3 integrin antibody. In addition, antibody activation of beta1 integrin restores the proliferation of epithelial cells treated with LN5 function-perturbing antibodies. These data indicate that a complex comprising LN5 and alpha3beta1 integrin is multifunctional and contributes not only to epithelial cell adhesion but also to the regulation of cell growth via a signaling pathway involving mitogen-activated protein kinase. We discuss our study in light of recent evidence that LN5 expression is up-regulated at the leading tips of tumors, where it may play a role in tumor cell proliferation. PMID- 9950676 TI - alpha1 and alpha2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression. AB - Tumor cell invasion relies on cell migration and extracellular matrix proteolysis. We investigated the contribution of different integrins to the invasive activity of mouse mammary carcinoma cells. Antibodies against integrin subunits alpha6 and beta1, but not against alpha1 and alpha2, inhibited cell locomotion on a reconstituted basement membrane in two-dimensional cell migration assays, whereas antibodies against beta1, but not against alpha6 or alpha2, interfered with cell adhesion to basement membrane constituents. Blocking antibodies against alpha1 integrins impaired only cell adhesion to type IV collagen. Antibodies against alpha1, alpha2, alpha6, and beta1, but not alpha5, integrin subunits reduced invasion of a reconstituted basement membrane. Integrins alpha1 and alpha2, which contributed only marginally to motility and adhesion, regulated proteinase production. Antibodies against alpha1 and alpha2, but not alpha6 and beta1, integrin subunits inhibited both transcription and protein expression of the matrix metalloproteinase stromelysin-1. Inhibition of tumor cell invasion by antibodies against alpha1 and alpha2 was reversed by addition of recombinant stromelysin-1. In contrast, stromelysin-1 could not rescue invasion inhibited by anti-alpha6 antibodies. Our data indicate that alpha1 and alpha2 integrins confer invasive behavior by regulating stromelysin-1 expression, whereas alpha6 integrins regulate cell motility. These results provide new insights into the specific functions of integrins during tumor cell invasion. PMID- 9950678 TI - Cleavage furrows formed between centrosomes lacking an intervening spindle and chromosomes contain microtubule bundles, INCENP, and CHO1 but not CENP-E. AB - PtK1 cells containing two independent mitotic spindles can cleave between neighboring centrosomes, in the absence of an intervening spindle, as well as at the spindle equators. We used same-cell video, immunofluorescence, and electron microscopy to compare the structure and composition of normal equatorial furrows with that of ectopic furrows formed between spindles. As in controls, ectopic furrows contained midbodies composed of microtubule bundles and an electron opaque matrix. Despite the absence of an intervening spindle and chromosomes, the midbodies associated with ectopic furrows also contained the microtubule-bundling protein CHO1 and the chromosomal passenger protein INCENP. However, CENP-E, another passenger protein, was not found in ectopic furrows but was always present in controls. We also examined cells in which the ectopic furrow initiated but relaxed. Although relaxing furrows contained overlapping microtubules from opposing centrosomes, they lacked microtubule bundles as well as INCENP and CHO1. Together these data suggest that the mechanism defining the site of furrow formation during mitosis in vertebrates does not depend on the presence of underlying microtubule bundles and chromosomes or on the stable association of INCENP or CHO1. The data also suggest that the completion of cytokinesis requires the presence of microtubule bundles and specific proteins (e.g., INCENP, CHO1, etc.) that do not include CENP-E. PMID- 9950677 TI - The multiple roles of Cyk1p in the assembly and function of the actomyosin ring in budding yeast. AB - The budding yeast IQGAP-like protein Cyk1p/Iqg1p localizes to the mother-bud junction during anaphase and has been shown to be required for the completion of cytokinesis. In this study, video microscopy analysis of cells expressing green fluorescent protein-tagged Cyk1p/Iqg1p demonstrates that Cyk1p/Iqg1p is a dynamic component of the contractile ring during cytokinesis. Furthermore, in the absence of Cyk1p/Iqg1p, myosin II fails to undergo the contraction-like size change at the end of mitosis. To understand the mechanistic role of Cyk1p/Iqg1p in actomyosin ring assembly and dynamics, we have investigated the role of the structural domains that Cyk1p/Iqg1p shares with IQGAPs. An amino terminal portion containing the calponin homology domain binds to actin filaments and is required for the assembly of actin filaments to the ring. This result supports the hypothesis that Cyk1p/Iqg1p plays a direct role in F-actin recruitment. Deletion of the domain harboring the eight IQ motifs abolishes the localization of Cyk1p/Iqg1p to the bud neck, suggesting that Cyk1p/Iqg1p may be localized through interactions with a calmodulin-like protein. Interestingly, deletion of the COOH terminal GTPase-activating protein-related domain does not affect Cyk1p/Iqg1p localization or actin recruitment to the ring but prevents actomyosin ring contraction. In vitro binding experiments show that Cyk1p/Iqg1p binds to calmodulin, Cmd1p, in a calcium-dependent manner, and to Tem1p, a small GTP binding protein previously found to be required for the completion of anaphase. These results demonstrate the critical function of Cyk1p/Iqg1p in regulating various steps of actomyosin ring assembly and cytokinesis. PMID- 9950679 TI - Interaction of fibroblast growth factor-2 (FGF-2) with free gangliosides: biochemical characterization and biological consequences in endothelial cell cultures. AB - Exogenous gangliosides affect the angiogenic activity of fibroblast growth factor 2 (FGF-2), but their mechanism of action has not been elucidated. Here, a possible direct interaction of sialo-glycolipids with FGF-2 has been investigated. Size exclusion chromatography demonstrates that native, but not heat-denatured, 125I-FGF-2 binds to micelles formed by gangliosides GT1b, GD1b, or GM1. Also, gangliosides protect native FGF-2 from trypsin digestion at micromolar concentrations, the order of relative potency being GT1b > GD1b > GM1 = GM2 = sulfatide > GM3 = galactosyl-ceramide, whereas asialo-GM1, neuraminic acid, and N-acetylneuramin-lactose were ineffective. Scatchard plot analysis of the binding data of fluorochrome-labeled GM1 to immobilized FGF-2 indicates that FGF-2/GM1 interaction occurs with a Kd equal to 6 microM. This interaction is inhibited by the sialic acid-binding peptide mastoparan and by the synthetic fragments FGF-2(112-129) and, to a lesser extent, FGF-2(130-155), whereas peptides FGF-2(10-33), FGF-2(39-59), FGF-2(86-96), and the basic peptide HIV-1 Tat(41-60) were ineffective. These data identify the COOH terminus of FGF-2 as a putative ganglioside-binding region. Exogenous gangliosides inhibit the binding of 125I-FGF-2 to high-affinity tyrosine-kinase FGF-receptors (FGFRs) of endothelial GM 7373 cells at micromolar concentrations. The order of relative potency was GT1b > GD1b > GM1 > sulfatide a = sialo-GM1. Accordingly, GT1b,GD1b, GM1, and GM2, but not GM3 and asialo-GM1, prevent the binding of 125I-FGF-2 to a soluble, recombinant form of extracellular FGFR-1. Conversely, the soluble receptor and free heparin inhibit the interaction of fluorochrome-labeled GM1 to immobilized FGF-2. In agreement with their FGFR antagonist activity, free gangliosides inhibit the mitogenic activity exerted by FGF-2 on endothelial cells in the same range of concentrations. Also in this case, GT1b was the most effective among the gangliosides tested while asialo-GM1, neuraminic acid, N acetylneuramin-lactose, galactosyl-ceramide, and sulfatide were ineffective. In conclusion, the data demonstrate the capacity of exogenous gangliosides to interact with FGF-2. This interaction involves the COOH terminus of the FGF-2 molecule and depends on the structure of the oligosaccharide chain and on the presence of sialic acid residue(s) in the ganglioside molecule. Exogenous gangliosides act as FGF-2 antagonists when added to endothelial cell cultures. Since gangliosides are extensively shed by tumor cells and reach elevated levels in the serum of tumor-bearing patients, our data suggest that exogenous gangliosides may affect endothelial cell function by a direct interaction with FGF-2, thus modulating tumor neovascularization. PMID- 9950680 TI - Detection of transient in vivo interactions between substrate and transporter during protein translocation into the endoplasmic reticulum. AB - The split-ubiquitin technique was used to detect transient protein interactions in living cells. Nub, the N-terminal half of ubiquitin (Ub), was fused to Sec62p, a component of the protein translocation machinery in the endoplasmic reticulum of Saccharomyces cerevisiae. Cub, the C-terminal half of Ub, was fused to the C terminus of a signal sequence. The reconstitution of a quasi-native Ub structure from the two halves of Ub, and the resulting cleavage by Ub-specific proteases at the C terminus of Cub, serve as a gauge of proximity between the two test proteins linked to Nub and Cub. Using this assay, we show that Sec62p is spatially close to the signal sequence of the prepro-alpha-factor in vivo. This proximity is confined to the nascent polypeptide chain immediately following the signal sequence. In addition, the extent of proximity depends on the nature of the signal sequence. Cub fusions that bore the signal sequence of invertase resulted in a much lower Ub reconstitution with Nub-Sec62p than otherwise identical test proteins bearing the signal sequence of prepro-alpha-factor. An inactive derivative of Sec62p failed to interact with signal sequences in this assay. These in vivo findings are consistent with Sec62p being part of a signal sequence-binding complex. PMID- 9950681 TI - Two heteromeric kinesin complexes in chemosensory neurons and sensory cilia of Caenorhabditis elegans. AB - Chemosensation in the nervous system of the nematode Caenorhabditis elegans depends on sensory cilia, whose assembly and maintenance requires the transport of components such as axonemal proteins and signal transduction machinery to their site of incorporation into ciliary structures. Members of the heteromeric kinesin family of microtubule motors are prime candidates for playing key roles in these transport events. Here we describe the molecular characterization and partial purification of two heteromeric kinesin complexes from C. elegans, heterotrimeric CeKinesin-II and dimeric CeOsm-3. Transgenic worms expressing green fluorescent protein driven by endogenous heteromeric kinesin promoters reveal that both CeKinesin-II and CeOsm-3 are expressed in amphid, inner labial, and phasmid chemosensory neurons. Additionally, immunolocalization experiments on fixed worms show an intense concentration of CeKinesin-II and CeOsm-3 polypeptides in the ciliated endings of these chemosensory neurons and a punctate localization pattern in the corresponding cell bodies and dendrites. These results, together with the phenotypes of known mutants in the pathway of sensory ciliary assembly, suggest that CeKinesin-II and CeOsm-3 drive the transport of ciliary components required for sequential steps in the assembly of chemosensory cilia. PMID- 9950682 TI - NF-kappaB and AP-1 activation by nitric oxide attenuated apoptotic cell death in RAW 264.7 macrophages. AB - A toxic dose of the nitric oxide (NO) donor S-nitrosoglutathione (GSNO; 1 mM) promoted apoptotic cell death of RAW 264.7 macrophages, which was attenuated by cellular preactivation with a nontoxic dose of GSNO (200 microM) or with lipopolysaccharide, interferon-gamma, and NG-monomethyl-L-arginine (LPS/IFN gamma/NMMA) for 15 h. Protection from apoptosis was achieved by expression of cyclooxygenase-2 (Cox-2). Here we investigated the underlying mechanisms leading to Cox-2 expression. LPS/IFN-gamma/NMMA prestimulation activated nuclear factor (NF)-kappaB and promoted Cox-2 expression. Cox-2 induction by low-dose GSNO demanded activation of both NF-kappaB and activator protein-1 (AP-1). NF-kappaB supershift analysis implied an active p50/p65 heterodimer, and a luciferase reporter construct, containing four copies of the NF-kappaB site derived from the murine Cox-2 promoter, confirmed NF-kappaB activation after NO addition. An NF kappaB decoy approach abrogated not only Cox-2 expression after low-dose NO or after LPS/IFN-gamma/NMMA but also inducible protection. The importance of AP-1 for Cox-2 expression and cell protection by low-level NO was substantiated by using the extracellular signal-regulated kinase inhibitor PD98059, blocking NO elicited Cox-2 expression, but leaving the cytokine signal unaltered. Transient transfection of a dominant-negative c-Jun mutant further attenuated Cox-2 expression by low-level NO. Whereas cytokine-mediated Cox-2 induction relies on NF-kappaB activation, a low-level NO-elicited Cox-2 response required activation of both NF-kappaB and AP-1. PMID- 9950683 TI - A cell-free system to study regulation of focal adhesions and of the connected actin cytoskeleton. AB - Assembly and modulation of focal adhesions during dynamic adhesive processes are poorly understood. We describe here the use of ventral plasma membranes from adherent fibroblasts to explore mechanisms regulating integrin distribution and function in a system that preserves the integration of these receptors into the plasma membrane. We find that partial disruption of the cellular organization responsible for the maintenance of organized adhesive sites allows modulation of integrin distribution by divalent cations. High Ca2+ concentrations induce quasi reversible diffusion of beta1 integrins out of focal adhesions, whereas low Ca2+ concentrations induce irreversible recruitment of beta1 receptors along extracellular matrix fibrils, as shown by immunofluorescence and electron microscopy. Both effects are independent from the presence of actin stress fibers in this system. Experiments with cells expressing truncated beta1 receptors show that the cytoplasmic portion of beta1 is required for low Ca2+-induced recruitment of the receptors to matrix fibrils. Analysis with function-modulating antibodies indicates that divalent cation-mediated receptor distribution within the membrane correlates with changes in the functional state of the receptors. Moreover, reconstitution experiments show that purified alpha-actinin colocalizes and redistributes with beta1 receptors on ventral plasma membranes depleted of actin, implicating binding of alpha-actinin to the receptors. Finally, we found that recruitment of exogenous actin is specifically restricted to focal adhesions under conditions in which new actin polymerization is inhibited. Our data show that the described system can be exploited to investigate the mechanisms of integrin function in an experimental setup that permits receptor redistribution. The possibility to uncouple, under cell-free conditions, events involved in focal adhesion and actin cytoskeleton assembly should facilitate the comprehension of the underlying molecular mechanisms. PMID- 9950684 TI - The small Mr Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum. AB - The function of the small-Mr Ras-like GTPase Rap1 remains largely unknown, but this protein has been demonstrated to regulate cortical actin-based morphologic changes in Dictyostelium and the oxidative burst in mammalian neutrophils. To test whether Rap1 regulates phagocytosis, we biochemically analyzed cell lines that conditionally and modestly overexpressed wild-type [Rap1 WT(+)], constitutively active [Rap1 G12T(+)], and dominant negative [Rap1 S17N(+)] forms of D. discoideum Rap1. The rates of phagocytosis of bacteria and latex beads were significantly higher in Rap1 WT(+) and Rap1 G12T(+) cells and were reduced in Rap1 S17N(+) cells. The addition of inhibitors of protein kinase A, protein kinase G, protein tyrosine kinase, or phosphatidylinositide 3-kinase did not affect phagocytosis rates in wild-type cells. In contrast, the addition of U73122 (a phospholipase C inhibitor), calphostin C (a protein kinase C inhibitor), and BAPTA-AM (an intracellular Ca2+ chelator) reduced phagocytosis rates by 90, 50, and 65%, respectively, suggesting both arms of the phospholipase C signaling pathways played a role in this process. Other protein kinase C-specific inhibitors, such as chelerythrine and bisindolylmaleimide I, did not reduce phagocytosis rates in control cells, suggesting calphostin C was affecting phagocytosis by interfering with a protein containing a diacylglycerol-binding domain. The addition of calphostin C did not reduce phagocytosis rates in Rap1 G12T(+) cells, suggesting that the putative diacylglycerol-binding protein acted upstream in a signaling pathway with Rap1. Surprisingly, macropinocytosis was significantly reduced in Rap1 WT(+) and Rap1 G12T(+) cells compared with control cells. Together our results suggest that Rap1 and Ca2+ may act together to coordinate important early events regulating phagocytosis. PMID- 9950685 TI - Novel regulation of type IV collagenase (matrix metalloproteinase-9 and -2) activities by transforming growth factor-beta1 in human prostate cancer cell lines. AB - The type IV collagenases/gelatinases matrix metalloproteinase-2 (MMP-2) and MMP-9 play a variety of important roles in both physiological and pathological processes and are regulated by various growth factors, including transforming growth factor-beta1 (TGF-beta1), in several cell types. Previous studies have suggested that cellular control of one or both collagenases can occur through direct transcriptional mechanisms and/or after secretion through proenzyme processing and interactions with metalloproteinase inhibitors. Using human prostate cancer cell lines, we have found that TGF-beta1 induces the MMP-9 proenzyme; however, this induction does not result from direct effects on gene transcription but, instead, through a protein synthesis-requiring process leading to increased MMP-9 mRNA stability. In addition, we have examined levels of TGF beta1 regulation of MMP-2 in one prostate cancer cell line and found that TGF beta1 induces higher secreted levels of this collagenase through increased stability of the secreted 72-kDa proenzyme. These results identify two novel nontranscriptional pathways for the cellular regulation of MMP-9 and MMP-2 collagenase gene expression and activities. PMID- 9950686 TI - Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalization. AB - Eps15 is a substrate for the tyrosine kinase of the epidermal growth factor receptor (EGFR) and is characterized by the presence of a novel protein:protein interaction domain, the EH domain. Eps15 also stably binds the clathrin adaptor protein complex AP-2. Previous work demonstrated an essential role for eps15 in receptor-mediated endocytosis. In this study we show that, upon activation of the EGFR kinase, eps15 undergoes dramatic relocalization consisting of 1) initial relocalization to the plasma membrane and 2) subsequent colocalization with the EGFR in various intracellular compartments of the endocytic pathway, with the notable exclusion of coated vesicles. Relocalization of eps15 is independent of its binding to the EGFR or of binding of the receptor to AP-2. Furthermore, eps15 appears to undergo tyrosine phosphorylation both at the plasma membrane and in a nocodazole-sensitive compartment, suggesting sustained phosphorylation in endocytic compartments. Our results are consistent with a model in which eps15 undergoes cycles of association:dissociation with membranes and suggest multiple roles for this protein in the endocytic pathway. PMID- 9950687 TI - Morphological and functional association of Sec22b/ERS-24 with the pre-Golgi intermediate compartment. AB - Yeast Sec22p participates in both anterograde and retrograde vesicular transport between the endoplasmic reticulum (ER) and the Golgi apparatus by functioning as a v-SNARE (soluble N-ethylmaleimide-sensitive factor [NSF] attachment protein receptor) of transport vesicles. Three mammalian proteins homologous to Sec22p have been identified and are referred to as Sec22a, Sec22b/ERS-24, and Sec22c, respectively. The existence of three homologous proteins in mammalian cells calls for detailed cell biological and functional examinations of each individual protein. The epitope-tagged forms of all three proteins have been shown to be primarily associated with the ER, although functional examination has not been carefully performed for any one of them. In this study, using antibodies specific for Sec22b/ERS-24, it is revealed that endogenous Sec22b/ERS-24 is associated with vesicular structures in both the perinuclear Golgi and peripheral regions. Colabeling experiments for Sec22b/ERS-24 with Golgi mannosidase II, the KDEL receptor, and the envelope glycoprotein G (VSVG) of vesicular stomatitis virus (VSV) en route from the ER to the Golgi under normal, brefeldin A, or nocodazole treated cells suggest that Sec22b/ERS-24 is enriched in the pre-Golgi intermediate compartment (IC). In a well-established semi-intact cell system that reconstitutes transport from the ER to the Golgi, transport of VSVG is inhibited by antibodies against Sec22b/ERS-24. EGTA is known to inhibit ER-Golgi transport at a stage after vesicle/transport intermediate docking but before the actual fusion event. Antibodies against Sec22b/ERS-24 inhibit ER-Golgi transport only when they are added before the EGTA-sensitive stage. Transport of VSVG accumulated in pre-Golgi IC by incubation at 15 degreesC is also inhibited by Sec22b/ERS-24 antibodies. Morphologically, VSVG is transported from the ER to the Golgi apparatus via vesicular intermediates that scatter in the peripheral as well as the Golgi regions. In the presence of antibodies against Sec22b/ERS-24, VSVG is seen to accumulate in these intermediates, suggesting that Sec22b/ERS-24 functions at the level of the IC in ER-Golgi transport. PMID- 9950688 TI - Chicken erythroid AE1 anion exchangers associate with the cytoskeleton during recycling to the Golgi. AB - Chicken erythroid AE1 anion exchangers receive endoglycosidase F (endo F) sensitive sugar modifications in their initial transit through the secretory pathway. After delivery to the plasma membrane, anion exchangers are internalized and recycled to the Golgi where they acquire additional N-linked modifications that are resistant to endo F. During recycling, some of the anion exchangers become detergent insoluble. The acquisition of detergent insolubility correlates with the association of the anion exchanger with cytoskeletal ankyrin. Reagents that inhibit different steps in the endocytic pathway, including 0.4 M sucrose, ammonium chloride, and brefeldin A, block the acquisition of endo F-resistant sugars and the acquisition of detergent insolubility by newly synthesized anion exchangers. The inhibitory effects of ammonium chloride on anion exchanger processing are rapidly reversible. Furthermore, AE1 anion exchangers become detergent insoluble more rapidly than they acquire endo F-resistant modifications in cells recovering from an ammonium chloride block. This suggests that the cytoskeletal association of the recycling anion exchangers occurs after release from the compartment where they accumulate due to ammonium chloride treatment, and prior to their transit through the Golgi. The recycling pool of newly synthesized anion exchangers is reflected in the steady-state distribution of the polypeptide. In addition to plasma membrane staining, anion exchanger antibodies stain a perinuclear compartment in erythroid cells. This perinuclear AE1 containing compartment is also stained by ankyrin antibodies and partially overlaps the membrane compartment stained by NBD C6-ceramide, a Golgi marker. Detergent extraction of erythroid cells in situ has suggested that a substantial fraction of the perinuclear pool of AE1 is cytoskeletal associated. The demonstration that erythroid anion exchangers interact with elements of the cytoskeleton during recycling to the Golgi suggests the cytoskeleton may be involved in the post-Golgi trafficking of this membrane transporter. PMID- 9950689 TI - Direct visualization of the human estrogen receptor alpha reveals a role for ligand in the nuclear distribution of the receptor. AB - The human estrogen receptor alpha (ER alpha) has been tagged at its amino terminus with the S65T variant of the green fluorescent protein (GFP), allowing subcellular trafficking and localization to be observed in living cells by fluorescence microscopy. The tagged receptor, GFP-ER, is functional as a ligand dependent transcription factor, responds to both agonist and antagonist ligands, and can associate with the nuclear matrix. Its cellular localization was analyzed in four human breast cancer epithelial cell lines, two ER+ (MCF7 and T47D) and two ER- (MDA-MB-231 and MDA-MB-435A), under a variety of ligand conditions. In all cell lines, GFP-ER is observed only in the nucleus in the absence of ligand. Upon the addition of agonist or antagonist ligand, a dramatic redistribution of GFP-ER from a reticular to punctate pattern occurs within the nucleus. In addition, the full antagonist ICI 182780 alters the nucleocytoplasmic compartmentalization of the receptor and causes partial accumulation in the cytoplasm in a process requiring continued protein synthesis. GFP-ER localization varies between cells, despite being cultured and treated in a similar manner. Analysis of the nuclear fluorescence intensity for variation in its frequency distribution helped establish localization patterns characteristic of cell line and ligand. During the course of this study, localization of GFP-ER to the nucleolar region is observed for ER- but not ER+ human breast cancer epithelial cell lines. Finally, our work provides a visual description of the "unoccupied" and ligand-bound receptor and is discussed in the context of the role of ligand in modulating receptor activity. PMID- 9950690 TI - The stem-loop binding protein (SLBP1) is present in coiled bodies of the Xenopus germinal vesicle. AB - The stem-loop binding protein (SLBP1) binds the 3' stem-loop of histone pre-mRNA and is required for efficient processing of histone transcripts in the nucleus. We examined the localization of SLBP1 in the germinal vesicle of Xenopus laevis oocytes. In spread preparations of germinal vesicle contents, an anti-SLBP1 antibody stained coiled bodies and specific chromosomal loci, including terminal granules, axial granules, and some loops. After injection of myc-tagged SLBP1 transcripts into the oocyte cytoplasm, newly translated myc-SLBP1 protein was detectable in coiled bodies within 4 h and in terminal and axial granules by 8 h. To identify the region(s) of SLBP1 necessary for subnuclear localization, we subcloned various parts of the SLBP1 cDNA and injected transcripts of these into the cytoplasm of oocytes. We determined that 113 amino acids at the carboxy terminus of SLBP1 are sufficient for coiled body localization and that disruption of a previously defined RNA-binding domain did not alter this localization. Coiled bodies also contain the U7 small nuclear ribonucleoprotein particle (snRNP), which participates in cleavage of the 3' end of histone pre-mRNA. The colocalization of SLBP1 and the U7 snRNP in the coiled body suggests coordinated control of their functions, perhaps through a larger histone-processing particle. Some coiled bodies are attached to the lampbrush chromosomes at the histone gene loci, consistent with the view that coiled bodies in the oocyte recruit histone processing factors to the sites of histone pre-mRNA transcription. The non histone chromosomal sites at which SLBP1 is found include the genes coding for 5 S rRNA, U1 snRNA, and U2 snRNA, suggesting a wider role for SLBP1 in the biosynthesis of small non-spliced RNAs. PMID- 9950692 TI - PROFILE: Potential for Advanced Technology to Improve Air Quality and Human Health in Shanghai. AB - / Air quality in most Asian cities is poor and getting worse. It will soon become impossible to sustain population, economic, and industrial growth without severe deterioration of the atmospheric environment. This paper addresses the city of Shanghai, the air-quality problems it faces over the next 30 years, and the potential of advanced technology to alleviate these problems. Population, energy consumption, and emission profiles are developed for the city at 0.1 degrees x 0.1 degrees resolution and extrapolated from 1990 to 2020 using sector-specific economic growth factors. Within the context of the RAINS-Asia model, eight technology scenarios are examined for their effects on ambient concentrations of sulfur dioxide and sulfate and their emission control costs. Without new control measures, it is projected that the number of people exposed to sulfur dioxide concentrations in excess of guidelines established by the World Health Organization will rise from 650,000 in 1990 to more than 14 million in 2020. It is apparent that efforts to reduce emissions are likely to have significant health benefits, measured in terms of the cost of reducing the number of people exposed to concentrations in excess of the guidelines ($10-50 annually per person protected). Focusing efforts on the control of new coal-fired power plants and industrial facilities has the greatest benefit. However, none of the scenarios examined is alone capable of arresting the increases in emissions, concentrations, and population exposure. It is concluded that combinations of stringent scenarios in several sectors will be necessary to stabilize the situation, at a potential cost of $500 million annually by the year 2020. KEY WORDS: Coal; China; Shanghai; Sulfur dioxide; Air quality; Health effects PMID- 9950693 TI - Transboundary Issues in Wilderness Management. AB - / The management of lands adjacent to federally designated wilderness is increasingly seen to have the potential to negatively impact wilderness resources and management objectives. This paper first examines the numerous and often conflicting laws and regulations that influence how managers can mitigate transboundary issues. We then examine the various types of transboundary issues, and describe how they impact wilderness resources. Transboundary issues include recreational use, extractive activities, fire management, exotic species introductions, aircraft overflights and military operations, water diversion, urban encroachment, and transported pollutants. KEY WORDS: Adjacent lands; Buffer zones; Ecosystem management; Wilderness; Zones of influence PMID- 9950694 TI - The Economic Value of Open Space: A Review and Synthesis. AB - / Communities increasingly face development pressures that can irreversibly alter open space lands. While the monetary costs and benefits of development are typically known, the corresponding values of natural lands are complex and difficult to measure. This paper reviews different concepts of economic value in relation to open space, describes methods for quantifying these values, and presents examples of each from published literature. Open space benefits accruing to citizens as market values or consumers' surplus include market and enhancement values, production values, natural systems value, use and nonuse values, and various intangible values. Economic impacts that open space lands have on local communities and economies include fiscal impacts on municipal budgets, expenditures from open space-related activities, and impacts from employment and tax revenues. These values are not universally present within a given community, nor are they quantitatively additive. However, a comprehensive consideration of the multiple values of open space will better inform community decisions about land conservation and development. KEY WORDS: Conservation; Economic value; Land use; Open space; Zoning PMID- 9950691 TI - Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein. AB - The GTPase dynamin has been clearly implicated in clathrin-mediated endocytosis of synaptic vesicle membranes at the presynaptic nerve terminal. Here we describe a novel 52-kDa protein in rat brain that binds the proline-rich C terminus of dynamin. Syndapin I (synaptic, dynamin-associated protein I) is highly enriched in brain where it exists in a high molecular weight complex. Syndapin I can be involved in multiple protein-protein interactions via a src homology 3 (SH3) domain at the C terminus and two predicted coiled-coil stretches. Coprecipitation studies and blot overlay analyses revealed that syndapin I binds the brain specific proteins dynamin I, synaptojanin, and synapsin I via an SH3 domain specific interaction. Coimmunoprecipitation of dynamin I with antibodies recognizing syndapin I and colocalization of syndapin I with dynamin I at vesicular structures in primary neurons indicate that syndapin I associates with dynamin I in vivo and may play a role in synaptic vesicle endocytosis. Furthermore, syndapin I associates with the neural Wiskott-Aldrich syndrome protein, an actin-depolymerizing protein that regulates cytoskeletal rearrangement. These characteristics of syndapin I suggest a molecular link between cytoskeletal dynamics and synaptic vesicle recycling in the nerve terminal. PMID- 9950695 TI - Tools for Groundwater Protection Planning: An Example from McHenry County, Illinois, USA. AB - / This paper presents an approach for producing aquifer sensitivity maps from three-dimensional geologic maps, called stack-unit maps. Stack-unit maps depict the succession of geologic materials to a given depth, and aquifer sensitivity maps interpret the successions according totheir ability to transmit potential contaminants. Using McHenry County, Illinois, as a case study, stack-unit maps and an aquifer sensitivity assessment were made to help land-use planners, public health officials, consultants, developers, and the public make informed decisions regarding land use. A map of aquifer sensitivity is important for planning because the county is one of the fastest growing counties in the nation, and highly vulnerable sand and gravel aquifers occur within 6 m of ground surface over 75% of its area. The aquifer sensitivity map can provide guidance to regulators seeking optimal protection of groundwater resources where these resources are particularly vulnerable. In addition, the map can be used to help officials direct waste-disposal and industrial facilities and other sensitive land-use practices to areas where the least damage is likely to occur, thereby reducing potential future liabilities. KEY WORDS: Geologic mapping; Groundwater; Aquifers; Aquifer sensitivity; Land-use planning PMID- 9950696 TI - Research: The Effect of Wetland Mitigation Banking on the Achievement of No-Net Loss. AB - / This study determines whether the 68 wetland mitigation banks in existence in the United States through 1 January 1996 are achieving no-net-loss of wetland acreage nationally and regionally. Although 74% of the individual banks achieve no-net-loss by acreage, overall, wetland mitigation banks are projected to result in a net loss of 21,328 acres of wetlands nationally, 52% of the acreage in banks, as already credited wetland acreages are converted to otheruses. While most wetland mitigation banks are using appropriate compensation methods and ratios, several of the largest banks use preservation or enhancement, instead of restoration or creation. Most of these preservation/enhancement banks use minimum mitigation ratios of 1:1, which is much lower than ratios given in current guidelines. Assuming that mitigation occurs in these banks as preservation at the minimum allowable ratio, ten of these banks, concentrated in the western Gulf Coast region, will account for over 99% of projected net wetland acreage loss associated with banks. We conclude that wetland mitigation banking is a conceptually sound environmental policy and planning tool, but only if applied according to recently issued guidelines that ensure no-net-loss of wetland functions and values. Wetland mitigation banking inevitably leads to geographic relocation of wetlands, and therefore changes, either positively or negatively, the functions they perform and ecosystem services they provide. KEY WORDS: Mitigation banking; Wetlands; Army Corps of Engineers; No-net-loss PMID- 9950697 TI - Responses of Riparian Cottonwoods to Alluvial Water Table Declines. AB - / Human demands for surface and shallow alluvial groundwater have contributed to the loss, fragmentation, and simplification of riparian ecosystems. Populus species typically dominate riparian ecosystems throughout arid and semiarid regions of North American and efforts to minimize loss of riparian Populus requires an integrated understanding of the role of surface and groundwater dynamics in the establishment of new, and maintenance of existing, stands. In a controlled, whole-stand field experiment, we quantified responses of Populus morphology, growth, and mortality to water stress resulting from sustained water table decline following in-channel sand mining along an ephemeral sandbed stream in eastern Colorado, USA. We measured live crown volume, radial stem growth, annual branch increment, and mortality of 689 live Populus deltoides subsp. monilifera stems over four years in conjunction with localized water table declines. Measurements began one year prior to mining and included trees in both affected and unaffected areas. Populus demonstrated a threshold response to water table declines in medium alluvial sands; sustained declines >/=1 m produced leaf desiccation and branch dieback within three weeks and significant declines in live crown volume, stem growth, and 88% mortality over a three-year period. Declines in live crown volume proved to be a significant leading indicator of mortality in the following year. A logistic regression of tree survival probability against the prior year's live crown volume was significant (-2 log likelihood = 270, chi2 with 1 df = 232, P < 0.0001) and trees with absolute declines in live crown volume of >/=30 during one year had survival probabilities <0.5 in the following year. In contrast, more gradual water table declines of thick similar0.5 m had no measurable effect on mortality, stem growth, or live crown volume and produced significant declines only in annual branch growth increments. Developing quantitative information on the timing and extent of morphological responses and mortality of Populus to the rate, depth, and duration of water table declines can assist in the design of management prescriptions to minimize impacts of alluvial groundwater depletion on existing riparian Populus forests. PMID- 9950698 TI - A Quantitative Method for Estimating Probable Public Costs of Hurricanes. AB - / A method is presented for estimating probable public costs resulting from damage caused by hurricanes, measured as local government expenditures approved for reimbursement under the Stafford Act Section 406 Public Assistance Program. The method employs a multivariate model developed through multiple regression analysis of an array of independent variables that measure meteorological, socioeconomic, and physical conditions related to the landfall of hurricanes within a local government jurisdiction. From the regression analysis we chose a log-log (base 10) model that explains 74% of the variance in the expenditure data using population and wind speed as predictors. We illustrate application of the method for a local jurisdiction-Lee County, Florida, USA. The results show that potential public costs range from $4.7 million for a category 1 hurricane with winds of 137 kilometers per hour (85 miles per hour) to $130 million for a category 5 hurricane with winds of 265 kilometers per hour (165 miles per hour). Based on these figures, we estimate expected annual public costs of $2.3 million. These cost estimates: (1) provide useful guidance for anticipating the magnitude of the federal, state, and local expenditures that would be required for the array of possible hurricanes that could affect that jurisdiction; (2) allow policy makers to assess the implications of alternative federal and state policies for providing public assistance to jurisdictions that experience hurricane damage; and (3) provide information needed to develop a contingency fund or other financial mechanism for assuring that the community has sufficient funds available to meet its obligations. KEY WORDS: Hurricane; Public costs; Local government; Disaster recovery; Disaster response; Florida; Stafford Act PMID- 9950699 TI - Land-Use Change and Carbon Flux Between 1970s and 1990s in Central Highlands of Chiapas, Mexico. AB - / We present results of a study in an intensively impacted and highly fragmented landscape in which we apply field-measured carbon (C) density values to land use/land-cover (LU/LC) statistics to estimate the flux of C between terrestrial ecosystems and the atmosphere from the 1970s and 1990s. Carbon densities were assigned to common LU/LC classes on vegetation maps produced by Mexican governmental organizations and, by differencing areas and C pools, net C flux was calculated from the central highlands of Chiapas, Mexico, during a 16-year period. The total area of closed forests was reduced by half while degraded and fragmented forests expanded 56% and cultivated land and pasture areas increased by 8% and 30%, respectively. Total mean C densities ranged from a high of 504 tons C/ha in the oak and evergreen cloud forests class to a low of 147 tons C/ha in the pasture class. The differences in total C densities among the various LU/LC classes were due to changes in biomass while soil organic matter C remained similar. We estimate that a total of 19.99 thick similar 10(6) tons C were released to the atmosphere during the period of time covered by our study, equal to approximately 34% of the 1975 vegetation C pool. The Chiapas highlands, while comprising just 0.3% of Mexico's surface area, contributed 3% of the net national C emissions. KEY WORDS: Land use; Land cover; Carbon flux; Forests; Chiapas highlands; Mexico PMID- 9950700 TI - Effects of Protective Fencing on Birds, Lizards, and Black-Tailed Hares in the Western Mojave Desert. AB - / Effects of protective fencing on birds, lizards, black-tailed hares (Lepus californicus), perennial plant cover, and structural diversity of perennial plants were evaluated from spring 1994 through winter 1995 at the Desert Tortoise Research Natural Area (DTNA), in the Mojave Desert, California. Abundance and species richness of birds were higher inside than outside the DTNA, and effects were larger during breeding than wintering seasons and during a high than a low rainfall year. Ash-throated flycatchers (Myiarchus cinerascens), cactus wrens (Campylorhynchus brunneicapillus), LeConte's thrashers (Toxostoma lecontei), loggerhead shrikes (Lanius ludovicianus), sage sparrows (Amphispiza belli), and verdins (Auriparus flaviceps) were more abundant inside than outside the DTNA. Nesting activity was also more frequent inside. Total abundance and species richness of lizards and individual abundances of western whiptail lizards (Cnemidophorous tigris) and desert spiny lizards (Sceloporus magister) were higher inside than outside. In contrast, abundance of black-tailed hares was lower inside. Structural diversity of the perennial plant community did not differ due to protection, but cover was 50% higher in protected areas. Black tailed hares generally prefer areas of low perennial plant cover, which may explain why they were more abundant outside than inside the DTNA. Habitat structure may not affect bird and lizard communities as much as availability of food at this desert site, and the greater abundance and species richness of vertebrates inside than outside the DTNA may correlate with abundances of seeds and invertebrate prey. KEY WORDS: Birds; Fenced protection; Lepus californicus, Lizards; Mojave Desert; Off-highway vehicles; Protected area management; Sheep grazing PMID- 9950701 TI - ENVIRONMENTAL AUDITING: Tendencies in the Development of Tracks in Open Areas. AB - / The study aimed to compare the rate of vehicle and pedestrian track development between an unprotected open area and a protected one during the last 50 years. The results indicate that: (1) the rate of change in the length of tracks per 1 square kilometer of a site has been four times greater in the unprotected area than in the protected area; (2) the number of area cells (the areas between the tracks) increased geometrically in the unprotected area, while the increase in the protected area was linear; and (3) most area cells (50%-70%) in the protected area in each of the years analyzed (except 1944) were smaller than 10 ha in size. However, an area cell greater than 100 ha has always been observed. In contrast, in the unprotected site the number of area cells increased with time while their area size decreased. Twenty-seven percent of the unprotected area is composed at present of area cells smaller in size than 1 ha. The development of a track system in the protected site changed moderately with a few peaks during the past 50 years. This trend is a result of land management policies that actively promote sustainable ecotourism. However, in the unprotected open area, the track system has changed continuously and drastically due to a lack of land conservation management. KEY WORDS: Track development; Protected open areas; Unprotected open areas PMID- 9950702 TI - Effects of Military Training Activities on Shrub-steppe Raptors in Southwestern Idaho, USA. AB - / Between 1991 and 1994, we assessed relative abundance, nesting success, and distribution of ferruginous hawks (Buteo regalis), northern harriers (Circus cyaneus), burrowing owls (Athene cunicularia), and short-eared owls (Asio flammeus) inside and outside a military training site in the Snake River Birds of Prey National Conservation Area, southwestern Idaho. The Orchard Training Area is used primarily for armored vehicle training and artillery firing by the Idaho Army National Guard. Relative abundance of nesting pairs inside and outside the training site was not significantly different from 1991 to 1993 but was significantly higher on the training site in 1994 (P &le 0.03). Nesting success varied among years but was not significantly different inside and outside the training site (P > 0.26). In 1994, short-eared owl and burrowing owl nests were significantly closer to firing ranges used early in the spring before owls laid eggs than were random points (P < 0.001). In 1993, distances from occupied burrowing owl nests to firing ranges used early in the year were similar to those from random points to the same firing ranges (P = 0.16). Military activity contributed to some nesting failures from 1992 to 1994, but some pairs nested successfully near military activity. KEY WORDS: Distribution; Military impacts; Nesting success; Raptors; Relative abundance; Shrub-steppe PMID- 9950703 TI - [Clinical application of chromosome haplotype analysis and mutation analysis to the diagnosis of Wilson's disease]. AB - OBJECTIVE: To set up the method of gene diagnosis of Wilson's disease (WD) by chromosome haplotype analysis and mutation detection. METHODS: This study selected 3 (CA)n repeat genetic markers,D13S316, D13S133 and D13S314 to construct the chromosome haplotype within 8 Han WD families. PCR-SSCP was used to reconfirm the diagnosis of the siblings of the probands in the families where in the disease-causing mutation had been detected. RESULTS: One asymptomatic WD patient and 5 heterozygotes were detected. CONCLUSION: In the WD families, the analysis of chromosome haplotype helps to make the diagnosis of siblings of the probands;for the WD families in which the disease-causing mutation has been ascertained, mutation analysis can provide direct and definite evidence for diagnosis. The combination of these two methods can provide more evidences for diagnosis. PMID- 9950704 TI - Effects of Code Growth and Parsimony Pressure on Populations in Genetic Programming. AB - Parsimony pressure, the explicit penalization of larger programs, has been increasingly used as a means of controlling code growth in genetic programming. However, in many cases parsimony pressure degrades the performance of the genetic program. In this paper we show that poor average results with parsimony pressure are a result of 'failed' populations that overshadow the results of populations that incorporate parsimony pressure successfully. Additionally, we show that the effect of parsimony pressure can be measured by calculating the relationship between program size and performance within the population. This measure can be used as a partial indicator of success or failure for individual populations. PMID- 9950705 TI - Collective Adaptation: The Exchange of Coding Segments. AB - Coding segments are those subsegments of the chromosome that contribute positively to the fitness evaluation of the chromosome. Clique detection is a NP complete problem in which we can detect such coding segments. We extract coding segments from chromosomes, and we investigate the duplication of coding segments inside the chromosome and the collection of coding segments outside of the chromosome. We find that duplication of coding segments inside the chromosomes provides a back-up mechanism for the search heuristics. We further find local search in a collective memory of coding segments outside of the chromosome, collective adaptation, enables the search heuristic to represent partial solutions that are larger than realistic chromosomes lengths and to express the solution outside of the chromosome. PMID- 9950706 TI - Code Growth, Explicitly Defined Introns, and Alternative Selection Schemes. AB - Previous work on introns and code growth in genetic programming is expanded on and tested experimentally. Explicitly defined introns are introduced to tree based representations as an aid to measuring and evaluating intron behavior. Although it is shown that introns do create code growth, they are not its only cause. Removing introns merely decreases the growth rate; it does not eliminate it. By systematically negating various forms of intron behavior, a deeper understanding of the causes of code growth is obtained, leading to the development of a system that keeps unnecessary bloat to a minimum. Alternative selection schemes and recombination operators are examined and improvements demonstrated over the standard selection methods in terms of both performance and parsimony. PMID- 9950707 TI - ptGAs-Genetic Algorithms Evolving Noncoding Segments by Means of Promoter/Terminator Sequences. AB - In this article we present work on chromosome structures for genetic algorithms (GAs) based on biological principles. Mainly, the influence of noncoding segments on GA behavior and performance is investigated. We compare representations with noncoding sequences at predefined, fixed locations with 'junk' code induced by the use of promoter/terminator sequences (ptGAs) that define start and end of a coding sequence, respectively. As one of the advantages of noncoding segments a few researchers have identified the reduction of the disruptive effects of crossover, and we solidify this argument by a formal analysis of crossover disruption probabilities for noncoding segments at fixed locations. The additional use of promoter/terminator sequences not only enables evolution of parameter values, but also allows for adaptation of number, size, and location of genes (problem parameters) on an artificial chromosome. Randomly generated chromosomes of fixed length carry different numbers of promoter/terminator sequences resulting in genes of varying size and location. Evolution of these ptGA chromosomes drives the number of parameters and their values to (sub)optimal solutions. Moreover, the formation of tightly linked building blocks is enhanced by self-organization of gene locations. We also introduce a new, nondisruptive crossover operator emerging from the ptGA gene structure with adaptive crossover rate, location, and number of crossover sites. For experimental comparisons of this genetic operator to conventional crossover in GAs, as well as properties of different ptGA chromosome structures, an artificial problem from the literature is utilized. Finally, the potential of ptGA is demonstrated on an NP-complete combinatorial optimization problem. PMID- 9950708 TI - Putting More Genetics into Genetic Algorithms. AB - The majority of current genetic algorithms (GAs), while inspired by natural evolutionary systems, are seldom viewed as biologically plausible models. This is not a criticism of GAs, but rather a reflection of choices made regarding the level of abstraction at which biological mechanisms are modeled, and a reflection of the more engineering-oriented goals of the evolutionary computation community. Understanding better and reducing this gap between GAs and genetics has been a central issue in an interdisciplinary project whose goal is to build GA-based computational models of viral evolution. The result is a system called Virtual Virus (VIV). The VIV incorporates a number of more biologically plausible mechanisms, including a more flexible genotype-to-phenotype mapping. In VIV the genes are independent of position, and genomes can vary in length and may contain noncoding regions, as well as duplicative or competing genes. Initial computational studies with VIV have already revealed several emergent phenomena of both biological and computational interest. In the absence of any penalty based on genome length, VIV develops individuals with long genomes and also performs more poorly (from a problem-solving viewpoint) than when a length penalty is used. With a fixed linear length penalty, genome length tends to increase dramatically in the early phases of evolution and then decrease to a level based on the mutation rate. The plateau genome length (i.e., the average length of individuals in the final population) generally increases in response to an increase in the base mutation rate. When VIV converges, there tend to be many copies of good alternative genes within the individuals. We observed many instances of switching between active and inactive genes during the entire evolutionary process. These observations support the conclusion that noncoding regions serve a positive step in understanding how GAs might exploit more of the power and flexibility of biological evolution while simultaneously providing better tools for understanding evolving biological systems. PMID- 9950709 TI - Introduction to the Special Issue: Variable-Length Representation and Noncoding Segments for Evolutionary Algorithms. PMID- 9950710 TI - Effects of background color on the global and local processing of hierarchically organized stimuli. AB - Recent studies have shown that (1) the global precedence effects in processing the hierarchically organized stimulus can be attenuated by eliminating the low spatial frequencies contained in the stimulus and (2) the human magnocellular pathway is responsible for processing low spatial frequencies and the pathway can be attenuated by imposing a red background on the stimulus. In the present study, a reaction-time experiment was conducted to examine the effect of background color of the stimulus to the processing of the hierarchically organized stimulus. The result showed that although the control condition (a green background) produced a prototypical asymmetric global interference, a red background that was equiluminant to the green background produced a symmetrical interference. It was concluded that the human magnocellular pathway is at least partially responsible in producing the global precedence effects. PMID- 9950711 TI - Graded functional activation in the visuospatial system with the amount of task demand. AB - Two studies examined how the amount and type of computational demand are related to fMRI-measured activation in three bilateral cortical regions involved in the Shepard-Metzler (1971) mental-rotation paradigm. The amount of demand for the computation of visuospatial coordinates was manipulated by presenting mental rotation problems with increasing angular disparity (0, 40, 80, or 120 degrees). Activation in both the left and right intraparietal sulcal regions increased linearly with angular disparity in two separate studies. Activation also occurred in the fusiform gyrus and inferior temporal regions, regions that are primarily associated with the processes of object and object-part identification. By contrast, the demand for object recognition and rotation processes was relatively low, and the demand for executing saccades was high in a control condition that required making a systematic visual scan of two grids. The grid-scanning condition resulted in relatively less activation in the parietal and inferior temporal regions but considerable activation in frontal areas that are associated with planning and executing saccades, including the precentral gyrus and sulcus into the posterior middle frontal region. These data suggest that the amount of activation in the various cortical regions that support visuospatial processing is related to the amount, as well as to the type, of computational demand. PMID- 9950712 TI - Cortical regions associated with perceiving, naming, and knowing about colors. AB - Positron emission tomography (PET) was used to investigate whether retrieving information about a specific object attribute requires reactivation of brain areas that mediate perception of that attribute. During separate PET scans, subjects passively viewed colored and equiluminant gray-scale Mondrians, named colored and achromatic objects, named the color of colored objects, and generated color names associated with achromatic objects. Color perception was associated with activations in the lingual and fusiform gyri of the occipital lobes, consistent with previous neuroimaging and human lesion studies. Retrieving information about object color (generating color names for achromatic objects relative to naming achromatic objects) activated the left inferior temporal, left frontal, and left posterior parietal cortices, replicating previous findings from this laboratory. When subjects generated color names for achromatic objects relative to the low-level baseline of viewing gray-scale Mondrians, additional activations in the left fusiform/lateral occipital region were detected. However, these activations were lateral to the occipital regions associated with color perception and identical to occipital regions activated when subjects simply named achromatic objects relative to the same low-level baseline. This suggests that the occipital activations associated with retrieving color information were due to the perception of object form rather than to the top-down influence of brain areas that mediate color perception. Taken together, these results indicate that retrieving previously acquired information about an object's typical color does not require reactivation of brain regions that subserve color perception. PMID- 9950713 TI - Neural evidence linking visual object enumeration and attention. AB - Visual object enumeration is rapid and accurate for four or fewer items but slow and error-prone for over four items. This dichotomy has recently been linked to visual attentional phenomena by findings suggesting that 'subitizing' of small sets of objects is preattentive whereas 'counting' of over four items demands spatial shifts of attention. We evaluated this link at a neural level, using H2 15-O positron emission tomography to measure changes in regional cerebral blood flow while subjects enumerated the number of target vertical bars that 'popped out' of a 16-bar visual display consisting of both horizontal and vertical bars. Relative to a condition with a single target, subitizing (one to four targets) activated foci in the occipital extrastriate cortex, consistent with involvement of early, preattentive visual processes. Relative to subitizing, counting (five to eight targets) activated a widespread network of brain regions, including multiple foci implicated in shifting visual attention-large regions of the superior parietal cortex bilaterally and a focus in the right inferior frontal cortex. These results offer the first direct neural support for mapping the subitizing-counting dichotomy onto separable processes mediating preattentive vision and shifts of visual attention. PMID- 9950714 TI - Blindsight in subjects with homonymous visual field defects. AB - Brain damage in the visual system can lead to apparently blind visual areas. However, more elaborate testing indicates that some visual ability may still exist for specific stimuli in the otherwise blind regions. This phenomenon is called 'blindsight' if subjects report no conscious awareness of visual stimuli but when forced to guess, nevertheless perform better than chance. It has mainly been suggested that secondary visual pathways are responsible for this phenomenon. However, no published study has clearly shown the neural mechanism responsible for blindsight. Furthermore, experimental artifacts may have been responsible for the appearance of the phenomenon in some subjects. In the present study, the visual fields of nine subjects were mapped and residual visual performance was examined in many areas using three different experimental procedures. Artifacts such as stray light or eye movements were well controlled. In addition, confidence ratings were required after each trial in the forced choice tests. The results show that only one subject with a lesion in the optic radiation had blindsight in two discrete areas of the affected visual field. Spared optic radiation fibers of the main (primary) geniculo-striate visual pathway were most likely to account for this finding. PMID- 9950715 TI - Frames of reference for mapping tactile stimuli in brain-damaged patients. AB - Twelve normal controls, twelve left-brain-damaged patients, and thirty-six right brain-damaged patients with or without tactile extinction or tactile neglect were asked to report light touches delivered to the left or the right hand or simultaneously to both hands. The hands could be in anatomic position or one hand could cross over the other. Moreover, the two hands could be in the left or the right hemispace or across the corporeal midline. Controls and nontactile extinction groups performed better when the hands were in anatomical than in crossed position. By contrast, patients with tactile extinction detected contralesional stimuli with higher accuracy in crossed than in anatomical position. This result suggests that, in these patients, impairments in detecting contralesional stimuli can be due not only to sensory but also to spatial factors contingent upon the position of the hands. There was no interaction between the effect of crossing the hands and the hemispace where the crossing took place. This suggests that coding the position of a hand as left or right does not necessarily occur in relation to the bodily midline, but it may arise from the computation of the position of the other hand. PMID- 9950716 TI - Conceptual processing during the conscious resting state. A functional MRI study. AB - Localized, task-induced decreases in cerebral blood flow are a frequent finding in functional brain imaging research but remain poorly understood. One account of these phenomena postulates processes ongoing during conscious, resting states that are interrupted or inhibited by task performance. Psychological evidence suggests that conscious humans are engaged almost continuously in adaptive processes involving semantic knowledge retrieval, representation in awareness, and directed manipulation of represented knowledge for organization, problem solving, and planning. If interruption of such 'conceptual' processes accounts for task-induced deactivation, tasks that also engage these conceptual processes should not cause deactivation. Furthermore, comparisons between conceptual and nonconceptual tasks should show activation during conceptual tasks of the same brain areas that are 'deactivated' relative to rest. To test this model, functional magnetic resonance imaging data were acquired during a resting state, a perceptual task, and a semantic retrieval task. A network of left-hemisphere polymodal cortical regions showed higher signal values during the resting state than during the perceptual task but equal values during the resting and semantic conditions. This result is consistent with the proposal that perceptual tasks interrupt processes ongoing during rest that involve many of the same brain areas engaged during semantic retrieval. As further evidence for this model, the same network of brain areas was activated in two direct comparisons between semantic and perceptual processing tasks. This same 'conceptual processing' network was also identified in several previous studies that contrasted semantic and perceptual tasks or resting and active states. The model proposed here offers a unified account of these findings and may help to explain several unanticipated results from prior studies of semantic processing. PMID- 9950717 TI - Functional anatomy of perceptual and semantic processing for odors. AB - The functional anatomy of perceptual and semantic processings for odors was studied using positron emission tomography (PET). The first experiment was a pretest in which 71 normal subjects were asked to rate 185 odorants in terms of intensity, familiarity, hedonicity, and comestibility and to name the odorants. This pretest was necessary to select the most appropriate stimuli for the different cognitive tasks of the second experiment. The second one was a PET experiment in which 15 normal subjects were scanned using the water bolus method to measure regional cerebral blood flow (rCBF) during the performance in three conditions. In the first (perceptual) condition, subjects were asked to judge whether an odor was familiar or not. In the second (semantic) condition, subjects had to decide whether an odor corresponded to a comestible item or not. In the third (detection) condition, subjects had to judge whether the perceived stimulus was made of an odor or was just air. It was hypothetized that the three tasks were hierarchically organized from a superficial detection level to a deep semantic level. Odorants were presented with an air-flow olfactometer, which allowed the stimulations to be synchronized with breathing. Subtraction of activation images obtained between familiarity and control judgments revealed that familiarity judgments were mainly associated with the activity of the right orbito-frontal area, the subcallosal gyrus, the left inferior frontal gyrus, the left superior frontal gyrus, and the anterior cingulate (Brodmann's areas 11, 25, 47, 9, and 32, respectively). The comestibility minus familiarity comparison showed that comestibility judgments selectively activated the primary visual areas. In contrast, a decrease in rCBF was observed in these same visual areas for familiarity judgments and in the orbito-frontal area for comestibility judgments. These results suggest that orbito-frontal and visual regions interact in odor processing in a complementary way, depending on the task requirements. PMID- 9950718 TI - Cerebral mechanisms of hypnotic induction and suggestion. AB - The neural mechanisms underlying hypnotic states and responses to hypnotic suggestions remain largely unknown and, to date, have been studied only with indirect methods. Here, the effects of hypnosis and suggestions to alter pain perception were investigated in hypnotizable subjects by using positron emission tomography (PET) measures of regional cerebral blood flow (rCBF) and electroencephalographic (EEG) measures of brain electrical activity. The experimental conditions included a restful state (Baseline) followed by hypnotic relaxation alone (Hypnosis) and by hypnotic relaxation with suggestions for altered pain unpleasantness (Hypnosis-with-Suggestion). During each scan, the left hand was immersed in neutral (35 degree C) or painfully hot (47 degrees C) water in the first two conditions and in painfully hot water in the last condition. Hypnosis was accompanied by significant increases in both occipital rCBF and delta EEG activity, which were highly correlated with each other (r = 0.70, p < 0.0001). Peak increases in rCBF were also observed in the caudal part of the right anterior cingulate sulcus and bilaterally in the inferior frontal gyri. Hypnosis-related decreases in rCBF were found in the right inferior parietal lobule, the left precuneus, and the posterior cingulate gyrus. Hypnosis with-suggestions produced additional widespread increases in rCBF in the frontal cortices predominantly on the left side. Moreover, the medial and lateral posterior parietal cortices showed suggestion-related increases overlapping partly with regions of hypnosis-related decreases. Results support a state theory of hypnosis in which occipital increases in rCBF and delta activity reflect the alteration of consciousness associated with decreased arousal and possible facilitation of visual imagery. Frontal increases in rCBF associated with suggestions for altered perception might reflect the verbal mediation of the suggestions, working memory, and top-down processes involved in the reinterpretation of the perceptual experience. These results provide a new description of the neurobiological basis of hypnosis, demonstrating specific patterns of cerebral activation associated with the hypnotic state and with the processing of hypnotic suggestions. PMID- 9950719 TI - Evolution of time coding systems. AB - The auditory and electrosensory systems contain circuits that are specialized for the encoding and processing of microsecond time differences. Analysis of these circuits in two specialists, weakly electric fish and barn owls, has uncovered common design principles and illuminated some aspects of their evolution. PMID- 9950720 TI - Computing with self-excitatory cliques: A model and an application to hyperacuity scale computation in visual cortex. AB - We present a model of visual computation based on tightly inter-connected cliques of pyramidal cells. It leads to a formal theory of cell assemblies, a specific relationship between correlated firing patterns and abstract functionality, and a direct calculation relating estimates of cortical cell counts to orientation hyperacuity. Our network architecture is unique in that (1) it supports a mode of computation that is both reliable and efficient; (2) the current-spike relations are modeled as an analog dynamical system in which the requisite computations can take place on the time scale required for an early stage of visual processing; and (3) the dynamics are triggered by the spatiotemporal response of cortical cells. This final point could explain why moving stimuli improve vernier sensitivity. PMID- 9950721 TI - Complex response to periodic inhibition in simple and detailed neuronal models. AB - Constant current injection with superimposed periodic inhibition gives rise to phase locking as well as chaotic activity in rat neocortical neurons. Here we compare the behavior of a leaky integrate-and-fire neural model with that of a biophysically realistic model of the rat neuron to determine which membrane properties influence the response to such stimuli. We find that only the biophysical model with voltage-sensitive conductances can produce chaotic behavior. PMID- 9950722 TI - Neuronal tuning: To sharpen or broaden? AB - Sensory and motor variables are typically represented by a population of broadly tuned neurons. A coarser representation with broader tuning can often improve coding accuracy, but sometimes the accuracy may also improve with sharper tuning. The theoretical analysis here shows that the relationship between tuning width and accuracy depends crucially on the dimension of the encoded variable. A general rule is derived for how the Fisher information scales with the tuning width, regardless of the exact shape of the tuning function, the probability distribution of spikes, and allowing some correlated noise between neurons. These results demonstrate a universal dimensionality effect in neural population coding. PMID- 9950723 TI - Narrow versus wide tuning curves: What's best for a population code? AB - Neurophysiologists are often faced with the problem of evaluating the quality of a code for a sensory or motor variable, either to relate it to the performance of the animal in a simple discrimination task or to compare the codes at various stages along the neuronal pathway. One common belief that has emerged from such studies is that sharpening of tuning curves improves the quality of the code, although only to a certain point; sharpening beyond that is believed to be harmful. We show that this belief relies on either problematic technical analysis or improper assumptions about the noise. We conclude that one cannot tell, in the general case, whether narrow tuning curves are better than wide ones; the answer depends critically on the covariance of the noise. The same conclusion applies to other manipulations of the tuning curve profiles such as gain increase. PMID- 9950724 TI - The effect of correlated variability on the accuracy of a population code. AB - We study the impact of correlated neuronal firing rate variability on the accuracy with which an encoded quantity can be extracted from a population of neurons. Contrary to widespread belief, correlations in the variabilities of neuronal firing rates do not, in general, limit the increase in coding accuracy provided by using large populations of encoding neurons. Furthermore, in some cases, but not all, correlations improve the accuracy of a population code. PMID- 9950725 TI - A neural network model of temporal code generation and position-invariant pattern recognition. AB - Numerous studies have suggested that the brain may encode information in the temporal firing pattern of neurons. However, little is known regarding how information may come to be temporally encoded and about the potential computational advantages of temporal coding. Here, it is shown that local inhibition may underlie the temporal encoding of spatial images. As a result of inhibition, the response of a given cell can be significantly modulated by stimulus features outside its own receptive field. Feedforward and lateral inhibition can modulate both the firing rate and temporal features, such as latency. In this article, it is shown that a simple neural network model can use local inhibition to generate temporal codes of handwritten numbers. The temporal encoding of a spatial pattern has the interesting and computationally beneficial feature of exhibiting position invariance. This work demonstrates a manner by which the nervous system may generate temporal codes and shows that temporal encoding can be used to create position-invariant codes. PMID- 9950726 TI - Probabilistic synaptic transmission in the associative net. AB - The associative net model of heteroassociative memory with binary-valued synapses has been extended to include recent experimental data indicating that in the hippocampus, one form of synaptic modification is a change in the probability of synaptic transmission. Pattern pairs are stored in the net by a version of the Hebbian learning rule that changes the probability of transmission at synapses where the presynaptic and post-synaptic units are simultaneously active from a low, base value to a high, modified value. Numerical calculations of the expected recall response of this stochastic associative net have been used to assess the performance for different values of the base and modified probabilities. If there is a cost incurred with generating the difference between these probabilities, then a difference of about 0. 4 is optimal. This corresponds to the magnitude of change seen experimentally. Performance can be greatly enhanced by using multiple cue presentations during recall. PMID- 9950727 TI - A stochastic self-organizing map for proximity data. AB - We derive an efficient algorithm for topographic mapping of proximity data (TMP), which can be seen as an extension of Kohonen's self-organizing map to arbitrary distance measures. The TMP cost function is derived in a Baysian framework of folded Markov chains for the description of autoencoders. It incorporates the data by a dissimilarity matrix D and the topographic neighborhood by a matrix H of transition probabilities. From the principle of maximum entropy, a nonfactorizing Gibbs distribution is obtained, which is approximated in a mean field fashion. This allows for maximum likelihood estimation using an expectation maximization algorithm. In analogy to the transition from topographic vector quantization to the self-organizing map, we suggest an approximation to TMP that is computationally more efficient. In order to prevent convergence to local minima, an annealing scheme in the temperature parameter is introduced, for which the critical temperature of the first phase transition is calculated in terms of D and H. Numerical results demonstrate the working of the algorithm and confirm the analytical results. Finally, the algorithm is used to generate a connection map of areas of the cat's cerebral cortex. PMID- 9950728 TI - High-order contrasts for independent component analysis. AB - This article considers high-order measures of independence for the independent component analysis problem and discusses the class of Jacobi algorithms for their optimization. Several implementations are discussed. We compare the proposed approaches with gradient-based techniques from the algorithmic point of view and also on a set of biomedical data. PMID- 9950729 TI - Variational learning in nonlinear gaussian belief networks. AB - We view perceptual tasks such as vision and speech recognition as inference problems where the goal is to estimate the posterior distribution over latent variables (e.g., depth in stereo vision) given the sensory input. The recent flurry of research in independent component analysis exemplifies the importance of inferring the continuous-valued latent variables of input data. The latent variables found by this method are linearly related to the input, but perception requires nonlinear inferences such as classification and depth estimation. In this article, we present a unifying framework for stochastic neural networks with nonlinear latent variables. Nonlinear units are obtained by passing the outputs of linear gaussian units through various nonlinearities. We present a general variational method that maximizes a lower bound on the likelihood of a training set and give results on two visual feature extraction problems. We also show how the variational method can be used for pattern classification and compare the performance of these nonlinear networks with other methods on the problem of handwritten digit recognition. PMID- 9950730 TI - Propagating distributions up directed acyclic graphs. AB - In a previous article, we considered game trees as graphical models. Adopting an evaluation function that returned a probability distribution over values likely to be taken at a given position, we described how to build a model of uncertainty and use it for utility-directed growth of the search tree and for deciding on a move after search was completed. In some games, such as chess and Othello, the same position can occur more than once, collapsing the game tree to a directed acyclic graph (DAG). This induces correlations among the distributions at sibling nodes. This article discusses some issues that arise in extending our algorithms to a DAG. We give a simply described algorithm for correctly propagating distributions up a game DAG, taking account of dependencies induced by the DAG structure. This algorithm is exponential time in the worst case. We prove that it is #P complete to propagate distributions up a game DAG correctly. We suggest how our exact propagation algorithm can yield a fast but inexact heuristic. PMID- 9950731 TI - Modeling and prediction of human behavior. AB - We propose that many human behaviors can be accurately described as a set of dynamic modes (e.g., Kalman filters) sequenced together by a Markov chain. We then use these dynamic Markov models to recognize human behaviors from sensory data and to predict human behaviors over a few seconds time. To test the power of this modeling approach, we report an experiment in which we were able to achieve 95% accuracy at predicting automobile drivers' subsequent actions from their initial preparatory movements. PMID- 9950732 TI - Analog VLSI-based modeling of the primate oculomotor system. AB - One way to understand a neurobiological system is by building a simulacrum that replicates its behavior in real time using similar constraints. Analog very large scale integrated (VLSI) electronic circuit technology provides such an enabling technology. We here describe a neuromorphic system that is part of a long-term effort to understand the primate oculomotor system. It requires both fast sensory processing and fast motor control to interact with the world. A one-dimensional hardware model of the primate eye has been built that simulates the physical dynamics of the biological system. It is driven by two different analog VLSI chips, one mimicking cortical visual processing for target selection and tracking and another modeling brain stem circuits that drive the eye muscles. Our oculomotor plant demonstrates both smooth pursuit movements, driven by a retinal velocity error signal, and saccadic eye movements, controlled by retinal position error, and can reproduce several behavioral, stimulation, lesion, and adaptation experiments performed on primates. PMID- 9950733 TI - JPEG quality transcoding using neural networks trained with a perceptual error measure. AB - A JPEG Quality Transcoder (JQT) converts a JPEG image file that was encoded with low image quality to a larger JPEG image file with reduced visual artifacts, without access to the original uncompressed image. In this article, we describe technology for JQT design that takes a pattern recognition approach to the problem, using a database of images to train statistical models of the artifacts introduced through JPEG compression. In the training procedure for these models, we use a model of human visual perception as an error measure. Our current prototype system removes 32.2% of the artifacts introduced by moderate compression, as measured on an independent test database of linearly coded images using a perceptual error metric. This improvement results in an average PSNR reduction of 0.634 dB. PMID- 9950734 TI - A unifying review of linear gaussian models. AB - Factor analysis, principal component analysis, mixtures of gaussian clusters, vector quantization, Kalman filter models, and hidden Markov models can all be unified as variations of unsupervised learning under a single basic generative model. This is achieved by collecting together disparate observations and derivations made by many previous authors and introducing a new way of linking discrete and continuous state models using a simple nonlinearity. Through the use of other nonlinearities, we show how independent component analysis is also a variation of the same basic generative model. We show that factor analysis and mixtures of gaussians can be implemented in autoencoder neural networks and learned using squared error plus the same regularization term. We introduce a new model for static data, known as sensible principal component analysis, as well as a novel concept of spatially adaptive observation noise. We also review some of the literature involving global and local mixtures of the basic models and provide pseudocode for inference and learning for all the basic models. PMID- 9950735 TI - Implicit learning in 3D object recognition: the importance of temporal context. AB - A novel architecture and set of learning rules for cortical self-organization is proposed. The model is based on the idea that multiple information channels can modulate one another's plasticity. Features learned from bottom-up information sources can thus be influenced by those learned from contextual pathways, and vice versa. A maximum likelihood cost function allows this scheme to be implemented in a biologically feasible, hierarchical neural circuit. In simulations of the model, we first demonstrate the utility of temporal context in modulating plasticity. The model learns a representation that categorizes people's faces according to identity, independent of viewpoint, by taking advantage of the temporal continuity in image sequences. In a second set of simulations, we add plasticity to the contextual stream and explore variations in the architecture. In this case, the model learns a two-tiered representation, starting with a coarse view-based clustering and proceeding to a finer clustering of more specific stimulus features. This model provides a tenable account of how people may perform 3D object recognition in a hierarchical, bottom-up fashion. PMID- 9950736 TI - Relation between retinotopical and orientation maps in visual cortex. AB - A recent study of cat visual cortex reported abrupt changes in the positions of the receptive fields of adjacent neurons whose preferred orientations strongly differed (Das & Gilbert, 1997). Using a simple cortical model, we show that this covariation of discontinuities in maps of orientation preference and local distortions in maps of visual space reflects collective effects of the lateral cortical feedback. PMID- 9950737 TI - A parallel noise-robust algorithm to recover depth information from radial flow fields. AB - A parallel algorithm operating on the units ('neurons') of an artificial retina is proposed to recover depth information in a visual scene from radial flow fields induced by ego motion along a given axis. The system consists of up to 600 radii with fewer than 65 radially arranged neurons on each radius. Neurons are connected only to their nearest neighbors, and they are excited as soon as a sufficiently strong gray-level change occurs. The time difference of two subsequently activated neurons is then used by the last-excited neuron to compute the depth information. All algorithmic calculations remain strictly local, and information is exchanged only between adjacent active neurons (except for the final read-out). This, in principle, permits parallel implementation. Furthermore, it is demonstrated that the calculation of the object coordinates requires only a single multiplication with a constant, which is dependent on only the retinal position of the active neuron. The initial restriction to local operations makes the algorithm very noise sensitive. In order to solve this problem, a predication mechanism is introduced. After an object coordinate has been determined, the active neuron computes the time when the next neuronal excitation should take place. This estimated time is transferred to the respective next neuron, which will wait for this excitation only within a certain time window. If the excitation fails to arrive within this window, the previously computed object coordinate is regarded as noisy and discarded. We will show that this predictive mechanism relies also on only a (second) single multiplication with another neuron-dependent constant. Thus, computational complexity remains low, and noisy depth coordinates are efficiently eliminated. Thus, the algorithm is very fast and operates in real time on 128 x 128 images even in a serial implementation on a relatively slow computer. The algorithm is tested on scenes of growing complexity, and a detailed error analysis is provided showing that the depth error remains very low in most cases. A comparison to standard flow-field analysis shows that our algorithm outperforms the older method by far. The analysis of the algorithm also shows that it is generally applicable despite its restrictions, because it is fast and accurate enough such that a complete depth percept can be composed from radial flow field segments. Finally, we suggest how to generalize the algorithm, waiving the restriction of radial flow. PMID- 9950738 TI - Independent component analysis using an extended infomax algorithm for mixed subgaussian and supergaussian sources. AB - An extension of the infomax algorithm of Bell and Sejnowski (1995) is presented that is able blindly to separate mixed signals with sub- and supergaussian source distributions. This was achieved by using a simple type of learning rule first derived by Girolami (1997) by choosing negentropy as a projection pursuit index. Parameterized probability distributions that have sub- and supergaussian regimes were used to derive a general learning rule that preserves the simple architecture proposed by Bell and Sejnowski (1995), is optimized using the natural gradient by Amari (1998), and uses the stability analysis of Cardoso and Laheld (1996) to switch between sub- and supergaussian regimes. We demonstrate that the extended infomax algorithm is able to separate 20 sources with a variety of source distributions easily. Applied to high-dimensional data from electroencephalographic recordings, it is effective at separating artifacts such as eye blinks and line noise from weaker electrical signals that arise from sources in the brain. PMID- 9950739 TI - Mixtures of probabilistic principal component analyzers. AB - Principal component analysis (PCA) is one of the most popular techniques for processing, compressing, and visualizing data, although its effectiveness is limited by its global linearity. While nonlinear variants of PCA have been proposed, an alternative paradigm is to capture data complexity by a combination of local linear PCA projections. However, conventional PCA does not correspond to a probability density, and so there is no unique way to combine PCA models. Therefore, previous attempts to formulate mixture models for PCA have been ad hoc to some extent. In this article, PCA is formulated within a maximum likelihood framework, based on a specific form of gaussian latent variable model. This leads to a well-defined mixture model for probabilistic principal component analyzers, whose parameters can be determined using an expectation-maximization algorithm. We discuss the advantages of this model in the context of clustering, density modeling, and local dimensionality reduction, and we demonstrate its application to image compression and handwritten digit recognition. PMID- 9950740 TI - Boosted mixture of experts: an ensemble learning scheme. AB - We present a new supervised learning procedure for ensemble machines, in which outputs of predictors, trained on different distributions, are combined by a dynamic classifier combination model. This procedure may be viewed as either a version of mixture of experts (Jacobs, Jordan, Nowlan, & Hintnon, 1991), applied to classification, or a variant of the boosting algorithm (Schapire, 1990). As a variant of the mixture of experts, it can be made appropriate for general classification and regression problems by initializing the partition of the data set to different experts in a boostlike manner. If viewed as a variant of the boosting algorithm, its main gain is the use of a dynamic combination model for the outputs of the networks. Results are demonstrated on a synthetic example and a digit recognition task from the NIST database and compared with classifical ensemble approaches. PMID- 9950741 TI - Boosting regression estimators. AB - There is interest in extending the boosting algorithm (Schapire, 1990) to fit a wide range of regression problems. The threshold-based boosting algorithm for regression used an analogy between classification errors and big errors in regression. We focus on the practical aspects of this algorithm and compare it to other attempts to extend boosting to regression. The practical capabilities of this model are demonstrated on the laser data from the Santa Fe times-series competition and the Mackey-Glass time series, where the results surpass those of standard ensemble average. PMID- 9950742 TI - An On-line agglomerative clustering method for nonstationary data. AB - An on-line agglomerative clustering algorithm for nonstationary data is described. Three issues are addressed. The first regards the temporal aspects of the data. The clustering of stationary data by the proposed algorithm is comparable to the other popular algorithms tested (batch and on-line). The second issue addressed is the number of clusters required to represent the data. The algorithm provides an efficient framework to determine the natural number of clusters given the scale of the problem. Finally, the proposed algorithm implicitly minimizes the local distortion, a measure that takes into account clusters with relatively small mass. In contrast, most existing on-line clustering methods assume stationarity of the data. When used to cluster nonstationary data, these methods fail to generate a good representation. Moreover, most current algorithms are computationally intensive when determining the correct number of clusters. These algorithms tend to neglect clusters of small mass due to their minimization of the global distortion (Energy). PMID- 9950743 TI - Hidden neural networks. AB - A general framework for hybrids of hidden Markov models (HMMs) and neural networks (NNs) called hidden neural networks (HNNs) is described. The article begins by reviewing standard HMMs and estimation by conditional maximum likelihood, which is used by the HNN. In the HNN, the usual HMM probability parameters are replaced by the outputs of state-specific neural networks. As opposed to many other hybrids, the HNN is normalized globally and therefore has a valid probabilistic interpretation. All parameters in the HNN are estimated simultaneously according to the discriminative conditional maximum likelihood criterion. The HNN can be viewed as an undirected probabilistic independence network (a graphical model), where the neural networks provide a compact representation of the clique functions. An evaluation of the HNN on the task of recognizing broad phoneme classes in the TIMIT database shows clear performance gains compared to standard HMMs tested on the same task. PMID- 9950744 TI - Hemopericardium in a patient with systemic lupus erythematosus. PMID- 9950745 TI - Administration of adenosine in sinus rhythm for diagnosis of supraventricular tachycardia. PMID- 9950746 TI - Evaluation of regional differences in right ventricular systolic function. PMID- 9950747 TI - Introduction: regulation of T cell development by the thymic microenvironment. PMID- 9950748 TI - In vitro models of T cell development. AB - A number of in vitro systems are currently being used to study both thymocyte development and thymic stromal cell function. However, the usefulness of dispersed culture systems is limited since they often involve disruption of interactions within the normal three-dimensional architecture of the thymus in vivo which are critical for normal development to proceed. In contrast, Fetal Thymus Organ Culture (FTOC) provides an experimental system where such interactions are maintained, thereby allowing in vitro access to key aspects of thymocyte development. More recently, Reaggregate Thymus Organ Cultures (RTOCs) have allowed detailed analysis of thymic stromal cell function, while retroviral transfection of thymocyte subsets under FTOC conditions provides a rapid means to investigate thymocyte development at the molecular level. Current use of the FTOC approach is summarised here, and where appropriate is compared to the use of dispersed culture systems. PMID- 9950749 TI - The human thymic microenvironment: new approaches to functional analysis. AB - Although immunohistological techniques have revealed molecular niches within the human thymic microenvironment, functional analysis is limited by the assay systems available. However, our recent studies using antibody phage display have revealed a high degree of molecular conservation between the microenvironmental molecules of different species. We have therefore isolated single-chain antibodies specific for evolutionarily conserved epitopes, shared by human and mouse, and used these in murine thymic functional assays. The detection of such shared human/rodent molecules makes it possible to functionally 'walk' from mouse to man, providing us with an experimental approach to functional analysis of the human thymus. PMID- 9950750 TI - Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR. AB - During lymphocyte development, cell-fate decisions are determined by a myriad of signals produced by the micro- environment of the thymus and the bone marrow. These yet to be fully defined developmental cues regulate stage-specific gene expression, and the extraordinarily well-characterized stages of T and B cell development have provided attractive model systems for studying regulation of cellular differentiation. In particular, studies on the contribution of both antigen receptors and cytokine receptors to lymphoid development have illuminated essential signalling pathways in early T and B cells. Here, we review investigations supporting an obligatory role for the IL-7 receptor pathway in early T cell development. IL-7 is produced by both thymus and bone marrow stromal cells, and its potential contribution to survival, differentiation and proliferation of pro-T cells is discussed. We also address the contribution of the pre-T cell receptor (pre-TCR) to differentiation past the pro-T cell stage, and recent advances in deciphering the composition and function of the pre-TCR complex are discussed. Finally, we suggest future directions in this field that may serve to reveal whether and how signals initiated by the cytokine receptors and pre-TCR may intersect, and to define which down-stream molecular events are regulated by these receptors. PMID- 9950751 TI - Development, organization and function of the thymic medulla in normal, immunodeficient or autoimmune mice. AB - Thymopoiesis is initiated by the colonisation of the epithelial rudiment with blood-borne hemopoietic precursors. Their subsequent differentiation to the functionally mature T cell subsets is exquisitely linked to sequential interaction with a diverse array of thymic epithelial cells which form discrete microenvironments. The development and organisation of the epithelium, however, is in turn controlled by thymocyte subsets. In particular the medulla organization depends upon activating signals provided by mature thymocytes to epithelial and dendritic cells. These signals are lacking in RelB-deficient mice leading to the disorganization of the corticomedullary junction and abnormal negative selection despite normal thymocyte maturation. This thymic stromal cell architecture phenotype is found in autoimmune diseases suggesting that abnormalities in the establishment of medullary microenvironments might be linked to the development of autoimmunity. PMID- 9950752 TI - Thymic microenvironments, 3-D versus 2-D? AB - Lympho-stromal interactions in the thymus crucially de- termine the fate of developing T cells. Epithelial cells, inter- digitating reticular cells, macrophages and fibroblasts all play a role in the shaping of the T cell repertoire. Recently published evidence shows that lympho-stromal interaction acts bi-directional. Developing T cell themselves, at different stages of differentiation, control the microarchitecture of thymic microenvironments, a phenomenon designated as 'crosstalk'. This paper reviews experiments showing that developing T cells crosstalk to different thymic epithelial cells in a stepwise fashion. In this way, correctly organized thymic microenvironments guarantee normal thymopoiesis. PMID- 9950753 TI - Using thymus anatomy to dissect T cell repertoire selection. AB - The thymic development of CD4(+) T cells incorporates the opposing processes of positive and negative selection to produce mature lymphocytes which respond to foreign peptides in the context of self-major histocompatibility complex class II molecules. Here, we present a model in which these events occur in two temporally and anatomically distinct steps. We propose that an initial positive selection step is mediated exclusively by thymic cortical epithelium. Subsequently, all those thymocytes which have been positively selected will interact with medullary epithelium and bone marrow-derived cells. Those thymocytes reacting with excess affinity or avidity to these antigen presenting cells will be negatively selected. Although acknowledging the importance of differential signalling to the developing thymocyte, we will emphasize the centrality of the phenotype of the tissues which comprise the thymus. PMID- 9950755 TI - Preservation of murine embryos in a state of dormancy at 4 degreesC. AB - With the aim of improving preservation of blood products and organs for transplantation, we designed solutions to induce a state of dormancy in cells and tissues at 4 degreesC. The solutions were devoid of combinations of ions (e.g., K+, Rb+, Cs+, and NH+4 with HCO-3, H2PO-4, and Cl-) that are believed to break down low-density water in the entrance compartments of ion channels, resulting in cyclical open states (normal water) and closed states (low-density water). The total osmolality was always 0.29-0.3 osmol/kgH2O, made up of combinations of a di or trisaccharide, a compatible solute, sodium sulfate, citrate, or chloride, and 1.75 mM CaCl2. The end point was the ability of murine embryos to progress to hatching in culture after preservation in such a solution at 4 degreesC. Embryos hatched after 5 or 6 days in some preservative solutions compared with 1-3 days in most saline solutions; survival was improved by pretreatment with sodium butyrate. PMID- 9950754 TI - Hypoxemia in the absence of blood loss upregulates iNOS expression and activity in macrophages. AB - Regional hypoxia, associated with hemorrhage, is thought to induce a variety of alterations in immune cell function, including upregulation of macrophage inducible nitric oxide synthase (iNOS) expression and activity (NO production). Furthermore, NO may cause immune cell dysfunction similar to that associated with hemorrhagic shock. However, it remains unknown whether hypoxia per se in the absence of any blood loss is a sufficient stimulus to cause iNOS expression and NO production by macrophages. To study this, male Sprague-Dawley rats (275-325 g) were placed in a plastic box flushed with a gas mixture containing 5% O2-95% N2 for 60 min. Peritoneal and splenic macrophages were isolated 0-5.5 h thereafter, and blood samples were obtained. Nitrite and nitrate (stable degradation products of NO) production by splenic and peritoneal macrophages cultured for 48 h was significantly increased 3 and 5.5 h after hypoxemia. The increase in NO production by macrophages was preceded by elevated expression of iNOS mRNA at 1.5 h after hypoxia. Additionally, interferon-gamma (IFN-gamma) levels in plasma from rats subjected to hypoxemia were significantly elevated soon after the insult (0 1.5 h posthypoxemia), suggesting a causal relationship between IFN-gamma production and upregulation of iNOS activity. We propose that a hypoxemia-induced increase in macrophage iNOS activity following hemorrhage may in part be responsible for the observed immune dysfunction. Thus attempts to suppress macrophage iNOS activity after this form of trauma may be helpful in improving immune function under those conditions. PMID- 9950756 TI - Regulation of ET-1 biosynthesis in cerebral microvascular endothelial cells by vasoactive agents and PKC. AB - Endothelin-1 (ET-1) is the most potent vasoconstrictor agent known. ET-1 is elevated in the cerebrospinal fluid following hemorrhage and brain injury and can compromise cerebral microvascular homeostasis. The modulation of ET-1 production by cerebral microvascular endothelial cells and the mechanism by which such changes take place are very important in our understanding of the pathological roles of ET-1. In the present study, we investigated the effects of vasoconstrictor agents that can be released from hemolyzed blood, cAMP-dependent dilators, and the role of protein kinase C (PKC) in the regulation of ET-1 production by piglet cerebral microvascular endothelial cells in culture. ET-1 was measured by RIA. 1) Cerebral microvascular endothelial cells synthesize and release ET-1 into the media; 2) 5-hydroxytryptamine (5-HT), lysophosphatidic acid (LPA), thromboxane analog U-46619, fetal bovine serum (20%), and phorbol 12 myristate 13-acetate significantly increase ET-1 production; 3) basal and vasoconstrictor agent-induced increases in ET-1 production by endothelial cells may be mediated via PKC; 4) cAMP-dependent vasodilators attenuate the basal production of ET-1 by cerebral microvessels; and 5) pretreatment of endothelial cells with a higher concentration of LPA, U-46619, or 5-HT counterbalances the cAMP-dependent dilator agent-induced reduction in basal ET-1 production. Therefore, by-products of hemolyzed blood can stimulate the production of ET-1 by a PKC-mediated mechanism. cAMP-dependent dilators can attenuate the vasoconstrictor agent-induced elevation in ET-1 production. These results suggest that cerebral microvascular homeostasis could be compromised by effects of interactions among vasoactive agents released during conditions injurious to the brain and they may further the understanding of potential contributions of hemolyzed blood clots to subarachnoid hemorrhage-induced vasospasm. PMID- 9950757 TI - Endocytosis at the apical plasma membrane of pancreatic acinar cells is regulated by tyrosine kinases. AB - We have shown that endocytosis at the apical plasma membrane of pancreatic acinar cells is regulated by the pH of the acinar lumen and is associated with cleavage of GP2, a glycosyl phosphatidylinositol-anchored protein. The aim of this study was to determine the transduction pathway by which endocytosis is activated. Apical endocytosis was studied in rat pancreatic acini by prestimulation with cholecystokinin followed by measurement of horseradish peroxidase (HRP) uptake. Lanthanum, staurosporine, and forskolin had no effect on HRP uptake. Cytochalasin D significantly inhibited endocytosis, indicating a dependence on actin filament integrity. Genistein and the specific tyrphostin inhibitor B42 also inhibited HRP uptake, implicating tyrosine kinases in the regulation of HRP uptake. With the use of an Src kinase-specific substrate, Src kinase activity was temporally related to activation of endocytosis. The tyrosine-dependent phosphorylation of an 85-kDa substrate in both rat and mouse pancreatic acini correlated with Src kinase activation and pH-dependent regulation of HRP uptake. These results indicate that apical endocytosis in acinar cells is associated with tyrosine kinase activation and is dependent on the actin cytoskeleton. PMID- 9950758 TI - Oxygen modulates Na+ absorption in middle ear epithelium. AB - The physiology of the middle ear is primarily concerned with keeping the cavities air filled and fluid free to allow transmission of the sound vibrations from the eardrum to the inner ear. Middle ear epithelial cells are thought to play a key role in this process, since they actively transport Na+ and water. The PO2 of the middle ear cavities varies from 44 to 54 mmHg in healthy human ears but may be lower in the course of secretory otitis media. The effect of chronic hypoxia on ion transport was investigated on a middle ear cell line using the short-circuit current technique. Chronic hypoxia reversibly decreased the rate of Na+ absorption across the MESV cell line. Although a decrease in cellular ATP content was observed, the decrease of Na+ absorption seemed related to a primary modulation of apical Na+ entry. As revealed by RNase protection assay, the decrease in the rate of apical Na+ entry strictly paralleled the decrease in the expression of transcripts encoding the alpha-subunit of the epithelial Na+ channel. This effect of oxygen on Na+ absorption might account for 1) the presence of fluid in the middle ear in the course of secretory otitis media and 2) the beneficial effect of the ventilation tube in treating otitis media that allows the PO2 to rise and restores the fluid clearance. PMID- 9950759 TI - Activation of mechanosensitive currents in traumatized membrane. AB - Mechanosensitive (MS) channels, ones whose open probability varies with membrane tension in patch recordings, are diverse and ubiquitous, yet many are remarkably insensitive to mechanical stimuli in situ. Failure to elicit mechanocurrents from cells with abundant MS channels suggests that, in situ, the channels are protected from mechanical stimuli. To establish what conditions affect MS channel gating, we monitored Lymnaea neuron stretch-activated K (SAK) channels in cell attached patches after diverse treatments. Mechanosensitivity was gauged by rapidity of onset and extent of channel activation during a step pressure applied to a "naive" patch. The following treatments enhanced mechanosensitivity: actin depolymerization (cytochalasin B), N-ethylmaleimide, an inhibitor of ATPases including myosin, elevated Ca (using A-23187), and osmotic swelling (acutely and after 24 h). Osmotic shrinking decreased mechanosensitivity. A unifying interpretation is that traumatized cortical cytoskeleton cannot prevent transmission of mechanical stimuli to plasma membrane channels. Mechanoprotection and capricious mechanosensitivity are impediments to cloning efforts with MS channels. We demonstrate a potpourri of endogenous MS currents from L-M(TK-) fibroblasts; others had reported these cells to be MS current null and hence to be suitable for expressing putative MS channels. PMID- 9950760 TI - Functional interaction of the K-Cl cotransporter (KCC1) with the Na-K-Cl cotransporter in HEK-293 cells. AB - We have studied the regulation of the K-Cl cotransporter KCC1 and its functional interaction with the Na-K-Cl cotransporter. K-Cl cotransporter activity was substantially activated in HEK-293 cells overexpressing KCC1 (KCC1-HEK) by hypotonic cell swelling, 50 mM external K, and pretreatment with N-ethylmaleimide (NEM). Bumetanide inhibited 86Rb efflux in KCC1-HEK cells after cell swelling [inhibition constant (Ki) approximately 190 microM] and pretreatment with NEM (Ki approximately 60 microM). Thus regulation of KCC1 is consistent with properties of the red cell K-Cl cotransporter. To investigate functional interactions between K-Cl and Na-K-Cl cotransporters, we studied the relationship between Na-K Cl cotransporter activation and intracellular Cl concentration ([Cl]i). Without stimulation, KCC1-HEK cells had greater Na-K-Cl cotransporter activity than controls. Endogenous Na-K-Cl cotransporter of KCC1-HEK cells was activated <2 fold by low-Cl hypotonic prestimulation, compared with 10-fold activation in HEK 293 cells and >20-fold activation in cells overexpressing the Na-K-Cl cotransporter (NKCC1-HEK). KCC1-HEK cells had lower resting [Cl]i than HEK-293 cells; cell volume was not different among cell lines. We found a steep relationship between [Cl]i and Na-K-Cl cotransport activity within the physiological range, supporting a primary role for [Cl]i in activation of Na-K-Cl cotransport and in apical-basolateral cross talk in ion-transporting epithelia. PMID- 9950761 TI - Estrogen modulates paracellular permeability of human endothelial cells by eNOS- and iNOS-related mechanisms. AB - Estradiol had a biphasic effect on permeability across cultures of human umbilical vein endothelial cells (HUVEC): at nanomolar concentrations it decreased the HUVEC culture permeability, but at micromolar concentrations it increased the permeability. The objective of the present study was to test the hypothesis that the changes in permeability were mediated by nitric oxide (NO) related mechanisms. The results revealed dual modulation of endothelial paracellular permeability by estrogen. 1) An endothelial NO synthase (eNOS)-, NO , and cGMP-related, Ca2+-dependent decrease in permeability was activated by nanomolar concentrations of estradiol, resulting in enhanced Cl- influx, increased cell size, and increases in the resistance of the lateral intercellular space (RLIS) and in the resistance of the tight junctions (RTJ); these effects appeared to be limited by the ability of cells to generate cGMP in response to NO. 2) An inducible NO synthase (iNOS)- and NO-related, Ca2+-independent increase in permeability was activated by micromolar concentrations of estradiol, resulting in enhanced Cl- efflux, decreased cell size, and decreased RLIS and RTJ. We conclude that the net effect on transendothelial permeability across HUVEC depends on the relative contributions of each of these two systems to the total paracellular resistance. PMID- 9950762 TI - Colonic H-K-ATPase beta-subunit: identification in apical membranes and regulation by dietary K depletion. AB - P-type ATPases require both alpha- and beta-subunits for functional activity. Although an alpha-subunit for colonic apical membrane H-K-ATPase (HKcalpha) has been identified and studied, its beta-subunit has not been identified. We cloned putative beta-subunit rat colonic H-K-ATPase (HKcbeta) cDNA that encodes a 279 amino-acid protein with a single transmembrane domain and sequence homology to other rat beta-subunits. Northern blot analysis demonstrates that this HKcbeta is expressed in several rat tissues, including distal and proximal colon, and is highly expressed in testis and lung. HKcbeta mRNA abundance is upregulated threefold compared with normal in distal colon but not proximal colon, testis, or lung of K-depleted rats. In contrast, Na-K-ATPase beta1 mRNA abundance is unaltered in distal colon of K-depleted rats. Na depletion, which also stimulates active K absorption in distal colon, does not increase HKcbeta mRNA abundance. Western blot analyses using a polyclonal antibody raised to a glutathione S transferase-HKcbeta fusion protein established expression of a 45-kDa HKcbeta protein in both apical and basolateral membranes of rat distal colon, but K depletion increased HKcbeta protein expression only in apical membranes. Physical association between HKcbeta and HKcalpha proteins was demonstrated by Western blot analysis performed with HKcbeta antibody on immunoprecipitate of apical membranes of rat distal colon and HKcalpha antibody. Tissue-specific upregulation of this beta-subunit mRNA in response to K depletion, localization of its protein, its upregulation by K depletion in apical membranes of distal colon, and its physical association with HKcalpha protein provide compelling evidence that HKcbeta is the putative beta-subunit of colonic H-K-ATPase. PMID- 9950763 TI - Adenosine and its nucleotides activate wild-type and R117H CFTR through an A2B receptor-coupled pathway. AB - ATP and its metabolites stimulate Cl- secretion in human epithelium in vitro and in vivo. The specific purinergic receptor subtypes that govern these effects have been difficult to separate, in part due to multiple parallel pathways for Cl- secretion in respiratory and intestinal epithelia. In a simplified model using COS-7 cells, we demonstrate acquisition of an ATP-, ADP-, AMP-, and adenosine (ADO)-regulated halide permeability specifically following expression of wild type (wt) cystic fibrosis transmembrane conductance regulator (CFTR). This halide permeability is blocked by the P1 purinergic receptor antagonist 8-phenyl theophylline, sensitive to the protein kinase A inhibitor H-89, and associated with a modest, dose-dependent increase in cellular cAMP concentration. Phorbol esters poorly activate halide permeability compared with ADO, and ADO-stimulated efflux was not affected by treatment with the protein kinase C inhibitor bisindolylmaleimide I. The A2 ADO receptor (AR) agonists 5'-N-ethylcarboxamide adenosine and ADO were strong activators, whereas the A1 AR agonist R phenylisopropyladenosine failed to activate halide permeability. Metabolic conversion of ADO nucleotides by surface ecto-5'-nucleotidase to more active (less phosphorylated) forms contributes to anion transport activation in these cells. Immunoprecipitation with anti-A2B AR antibody identified a 31-kDa protein in both COS-7 and human bronchial epithelial cells. Together, these findings indicate that ADO and its nucleotides are capable of activating wtCFTR-dependent halide permeability through A2B AR and that this AR subtype is present in human bronchial epithelium. We also present data showing that this pathway can activate clinically significant mutant CFTR molecules such as R117H. PMID- 9950765 TI - Effect of progesterone on intracellular Ca2+ homeostasis in human myometrial smooth muscle cells. AB - Although it is well known that progesterone alters uterine contractility and plays an important role in maintenance of pregnancy, the biochemical mechanisms by which progesterone alters uterine contractility in human gestation are less clear. In this investigation we sought to identify progesterone-induced adaptations in human myometrial smooth muscle cells that may alter Ca2+ signaling in response to contractile agents. Cells were treated with vehicle or the progesterone analog medroxyprogesterone acetate (MPA) for 5 days, and intracellular free Ca2+ concentration ([Ca2+]i) was quantified after treatment with oxytocin (OX) or endothelin (ET)-1. OX- and ET-1-induced increases in [Ca2+]i were significantly attenuated in cells pretreated with MPA in a dose dependent manner. Progesterone receptor antagonists prevented the attenuated Ca2+ transients induced by MPA. ETA and ETB receptor subtypes were expressed in myometrial cells, and treatment with MPA resulted in significant downregulation of ETA and ETB receptor binding. MPA did not alter ionomycin-stimulated increases in [Ca2+]i and had no effect on inositol trisphosphate-dependent or -independent release of Ca2+ from internal Ca2+ stores. We conclude that adaptations of Ca2+ homeostasis in myometrial cells during pregnancy may include progesterone-induced modification of receptor-mediated increases in [Ca2+]i. PMID- 9950764 TI - Phosphorylation of P-glycoprotein by PKA and PKC modulates swelling-activated Cl- currents. AB - Several proteins belonging to the ATP-binding cassette superfamily can affect ion channel function. These include the cystic fibrosis transmembrane conductance regulator, the sulfonylurea receptor, and the multidrug resistance protein P glycoprotein (MDR1). We measured whole cell swelling-activated Cl- currents (ICl,swell) in parental cells and cells expressing wild-type MDR1 or a phosphorylation-defective mutant (Ser-661, Ser-667, and Ser-671 replaced by Ala). Stimulation of protein kinase C (PKC) with a phorbol ester reduced the rate of increase in ICl,swell only in cells that express MDR1. PKC stimulation had no effect on steady-state ICl,swell. Stimulation of protein kinase A (PKA) with 8 bromoadenosine 3',5'-cyclic monophosphate reduced steady-state ICl, swell only in MDR1-expressing cells. PKA stimulation had no effect on the rate of ICl,swell activation. The effects of stimulation of PKA and PKC on ICl,swell were additive (i.e., decrease in the rate of activation and reduction in steady-state ICl,swell). The effects of PKA and PKC stimulation were absent in cells expressing the phosphorylation-defective mutant. In summary, it is likely that phosphorylation of MDR1 by PKA and by PKC alters swelling-activated Cl- channels by independent mechanisms and that Ser-661, Ser-667, and Ser-671 are involved in the responses of ICl,swell to stimulation of PKA and PKC. These results support the notion that MDR1 phosphorylation affects ICl,swell. PMID- 9950766 TI - Phenotypic abnormalities in macrophages from leptin-deficient, obese mice. AB - Obesity is a complex syndrome that involves defective signaling by a number of different factors that regulate appetite and energy homeostasis. Treatment with exogenous leptin reverses hyperphagia and obesity in ob/ob mice, which have a mutation that causes leptin deficiency, proving the importance of this factor and its receptors in the obesity syndrome. Cells with leptin receptors have been identified outside of the appetite regulatory centers in the brain. Thus leptin has peripheral targets. Because macrophages express signaling-competent leptin receptors, these cells may be altered during chronic leptin deficiency. Consistent with this concept, the present study identifies several phenotypic abnormalities in macrophages from ob/ob mice, including decreased steady-state levels of uncoupling protein-2 mRNA, increased mitochondrial production of superoxide and hydrogen peroxide, constitutive activation of CCAAT enhancer binding protein (C/EBP)-beta, an oxidant-sensitive transcription factor, increased expression of interleukin-6 and cyclooxygenase (COX)-2, two C/EBP-beta target genes, and increased COX-2-dependent production of PGE2. Given the importance of macrophages in the general regulation of inflammation and immunity, these alterations in macrophage function may contribute to obesity-related pathophysiology. PMID- 9950767 TI - Prolonged contraction-relaxation cycle of fast-twitch muscles in parvalbumin knockout mice. AB - The calcium-binding protein parvalbumin (PV) occurs at high concentrations in fast-contracting vertebrate muscle fibers. Its putative role in facilitating the rapid relaxation of mammalian fast-twitch muscle fibers by acting as a temporary buffer for Ca2+ is still controversial. We generated knockout mice for PV (PV -/ ) and compared the Ca2+ transients and the dynamics of contraction of their muscles with those from heterozygous (PV +/-) and wild-type (WT) mice. In the muscles of PV-deficient mice, the decay of intracellular Ca2+ concentration ([Ca2+]i) after 20-ms stimulation was slower compared with WT mice and led to a prolongation of the time required to attain peak twitch tension and to an extension of the half-relaxation time. The integral [Ca2+]i in muscle fibers of PV -/- mice was higher and consequently the force generated during a single twitch was approximately 40% greater than in PV +/- and WT animals. Acceleration of the contraction-relaxation cycle of fast-twitch muscle fibers by PV may confer an advantage in the performance of rapid, phasic movements. PMID- 9950768 TI - Cadherin function in junctional complex rearrangement and posttranslational control of cadherin expression. AB - The role of E-cadherin, a calcium-dependent adhesion protein, in organizing and maintaining epithelial junctions was examined in detail by expressing a fusion protein (GP2-Cad1) composed of the extracellular domain of a nonadherent glycoprotein (GP2) and the transmembrane and cytoplasmic domains of E-cadherin. All studies shown were also replicated using an analogous cell line that expresses a mutant cadherin construct (T151) under the control of tet repressor. Mutant cadherin was expressed at approximately 10% of the endogenous E-cadherin level and had no apparent effect on tight junction function or on distributions of adherens junction, tight junction, or desmosomal marker proteins in established Madin-Darby canine kidney cell monolayers. However, GP2-Cad1 accelerated the disassembly of epithelial junctional complexes and delayed their reassembly in calcium switch experiments. Inducing expression of GP2-Cad1 to levels approximately threefold greater than endogenous E-cadherin expression levels in control cells resulted in a decrease in endogenous E-cadherin levels. This was due in part to increased protein turnover, indicating a cellular mechanism for sensing and controlling E-cadherin levels. Cadherin association with catenins is necessary for strong cadherin-mediated cell-cell adhesion. In cells expressing low levels of GP2-Cad1, protein levels and stoichiometry of the endogenous cadherin-catenin complex were unaffected. Thus effects of GP2-Cad1 on epithelial junctional complex assembly and stability were not due to competition with endogenous E-cadherin for catenin binding. Rather, we suggest that GP2-Cad1 interferes with the packing of endogenous cadherin-catenin complexes into higher order structures in junctional complexes that results in junction destabilization. PMID- 9950769 TI - EGF induces nuclear translocation of STAT2 without tyrosine phosphorylation in intestinal epithelial cells. AB - Signal transducers and activators of transcription (STATs) are cytoplasmic proteins that bind to activated membrane receptors, undergo ligand-dependent phosphorylation on tyrosine residues, and translocate to the nucleus, where they induce transcription of specific genes in response to a variety of ligands, including cytokines and some growth factors. Using immunocytochemical and biochemical techniques, we investigated the localization and responses of STAT1 and STAT2 to epidermal growth factor (EGF) stimulation in IEC-6 intestinal epithelial cells and HeLa cells. These studies provide the first description of STAT activation and localization in response to EGF in intestinal epithelial cells and some novel findings regarding the activation and localization of STATs in general. These include the following. First, EGF promoted the tyrosine phosphorylation of STAT1 in IEC-6 cells and caused its translocation to the nucleus. Second, in the absence of EGF stimulation both STAT1 and STAT2 were localized to the Golgi apparatus in IEC-6 cells. Third, EGF caused the translocation of STAT2 to the nucleus in both IEC-6 and HeLa cells without inducing the tyrosine phosphorylation of STAT2. PMID- 9950770 TI - Imaging of intracellular calcium stores in single permeabilized lens cells. AB - Intracellular Ca2+ stores in permeabilized sheep lens cells were imaged with mag fura 2 to characterize their distribution and sensitivity to Ca2+-releasing agents. Inositol 1,4,5-trisphosphate (IP3) or cyclic ADP-ribose (cADPR) released Ca2+ from intracellular Ca2+ stores that were maintained by an ATP-dependent Ca2+ pump. The IP3 antagonist heparin inhibited IP3- but not cADPR-mediated Ca2+ release, whereas the cADPR antagonist 8-amino-cADPR inhibited cADPR- but not IP3 mediated Ca2+ release, indicating that IP3 and cADPR were operating through separate mechanisms. A Ca2+ store sensitive to IP3, cADPR, and thapsigargin appeared to be distributed throughout all intracellular regions. In some cells a Ca2+ store insensitive to IP3, cADPR, thapsigargin, and 2,4-dinitrophenol, but not ionomycin, was present in a juxtanuclear region. We conclude that lens cells contain intracellular Ca2+ stores that are sensitive to IP3, cADPR, and thapsigargin, as well as a Ca2+ store that appears insensitive to all these agents. PMID- 9950771 TI - Resistance to TNF-alpha cytotoxicity can be achieved through different signaling pathways in rat mesangial cells. AB - We reported previously that Ro-318220 blocked expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) induced by tumor necrosis factor-alpha (TNF alpha) and subsequently caused apopotosis in mesangial cells (Y.-L. Guo, B. Kang, and J. R. Williamson. J. Biol. Chem. 273: 10362-10366, 1998). These data support our hypothesis that a TNF-alpha-inducible phosphatase may be responsible for preventing sustained activation of c-Jun NH2-terminal protein kinase (JNK) and consequent cell death in these cells (Y.-L. Guo, K. Baysal, B. Kang, L.-J. Yang, and J. R. Williamson. J. Biol. Chem. 273: 4027-4034, 1998). In this study, we investigated the involvement of protein kinase C (PKC) in regulation of MKP-1 expression in mesangial cells together with effects on viability. Although originally characterized as a PKC inhibitor, Ro-318220 inhibited TNF-alpha induced MKP-1 expression through a mechanism other than blocking the PKC pathway. Furthermore, inhibition of the PKC pathway neither significantly affected TNF alpha-induced MKP-1 expression nor made cells susceptible to toxic effect of TNF alpha. Thus PKC activation is not essential for cells to achieve the resistance to TNF-alpha cytotoxicity displayed by normal mesangial cells. However, activation of PKC by phorbol 12-myristate 13-acetate (PMA) dramatically increased cellular resistance to the apoptotic effect of TNF-alpha. Coincidentally, PMA stimulated MKP-1 expression and suppressed JNK activation. Therefore, PMA-induced MKP-1 expression may contribute to the protective effect of PMA. These results provide a mechanistic explanation for previous documentation that PKC activation can rescue some cells from apopotosis. PMID- 9950772 TI - Cloning, characterization, and functional expression of a CNP receptor regulating CFTR in the shark rectal gland. AB - In the shark, C-type natriuretic peptide (CNP) is the only cardiac natriuretic hormone identified and is a potent activator of Cl- secretion in the rectal gland, an epithelial organ of this species that contains cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels. We have cloned an ancestral CNP receptor (NPR-B) from the shark rectal gland that has an overall amino acid identity to the human homologue of 67%. The shark sequence maintains six extracellular Cys present in other NPR-B but lacks a glycosylation site and a Glu residue previously considered important for CNP binding. When shark NPR-B and human CFTR were coexpressed in Xenopus oocytes, CNP increased the cGMP content of oocytes (EC50 12 nM) and activated CFTR Cl- channels (EC50 8 nM). Oocyte cGMP increased 36-fold (from 0.11 +/- 0.03 to 4.03 +/- 0.45 pmol/oocyte) and Cl- current increased 37-fold (from -34 +/- 14 to -1,226 +/- 151 nA) in the presence of 50 nM CNP. These findings identify the specific natriuretic peptide receptor responsible for Cl- secretion in the shark rectal gland and provide the first evidence for activation of CFTR Cl- channels by a cloned NPR-B receptor. PMID- 9950773 TI - Hypoxia-induced expression of complement receptor type 1 (CR1, CD35) in human vascular endothelial cells. AB - Reoxygenation of hypoxic human umbilical vein endothelial cells (HUVECs) increases protein expression of the complement regulators CD46 and CD55. As the receptor for C3b is known to be present on injured bovine endothelial cells, we investigated whether hypoxia or inflammatory mediators induce complement receptor type 1 (CR1; CD35) expression on HUVECs. CR1 protein expression increased 3.7 +/- 0. 6-fold as measured by ELISA on HUVECs following hypoxia (48 h, 1% O2). Colocalization of CD35 and von Willebrand factor by confocal microscopy confirmed that CD35 was predominantly intracellular. Lipopolysaccharide or tumor necrosis factor-alpha also significantly increased HUVEC CR1 protein expression. Western blot analysis of neutrophil or hypoxic HUVEC lysates revealed a 221-kDa CR1 band under nonreducing conditions. RT-PCR of hypoxic HUVEC mRNA revealed a single band that, after sequencing, was identified as CD35. In situ hybridization of hypoxic HUVECs, but not normoxic HUVECs or fibroblasts, demonstrated increased CD35 mRNA. Hypoxic HUVECs bound immune complexes and acted as a cofactor for factor I mediated cleavage of C3b. Thus hypoxia induces functional HUVEC CR1 expression. PMID- 9950774 TI - Polyamine depletion alters the relationship of F-actin, G-actin, and thymosin beta4 in migrating IEC-6 cells. AB - The cause of reduced migration ability in polyamine-deficient cells is not known, but their actin cytoskeleton is clearly abnormal. We depleted polyamines with alpha-difluoromethylornithine (DFMO) in migrating cells with or without stimulation by epidermal growth factor (EGF) and investigated filamentous (F-) actin, monomeric (G-) actin, and thymosin beta4 (Tbeta4), using immunofluorescent confocal microscopy, DNase assay, and immunoblot analysis. DFMO reduced F-actin in the cell interior, increased it in the cell cortex, redistributed G-actin, and increased nuclear staining of Tbeta4. However, DFMO did not affect the amount of Tbeta4 mRNA. EGF caused a rapid increase in the staining of F-actin in control cells, but DFMO prevented this response to EGF. Despite the visible changes shown by immunocytochemistry, statistically significant changes in the amount of either actin isoform or of total actin did not occur. We propose that DFMO reduces migration by interfering with the sequestration of G-actin by Tbeta4 and the association of F-actin with activated EGF receptors. PMID- 9950775 TI - Airway surface fluid volume and Cl content in cystic fibrosis and normal bronchial xenografts. AB - We describe the use of an in vivo human bronchial xenograft model of cystic fibrosis (CF) and non-CF airways to investigate pathophysiological alterations in airway surface fluid (ASF) volume (Vs) and Cl content. Vs was calculated based on the dilution of an impermeable marker, [3H]inulin, during harvesting of ASF from xenografts with an isosmotic Cl-free solution. These calculations demonstrated that Vs in CF xenographs (28 +/- 3.0 microliter/cm2; n = 17) was significantly less than that of non-CF xenografts (35 +/- 2. 4 microliter/cm2; n = 30). The Cl concentration of ASF ([Cl]s) was determined using a solid-state AgCl electrode and adjusted for dilution during harvesting using the impermeable [3H]inulin marker. Cumulative results demonstrate small but significant elevations (P < 0.045) in [Cl]s in CF (125 +/- 4 mM; n = 27) compared with non-CF (114 +/- 4 mM; n = 48) xenografts. To investigate potential mechanisms by which CF airways may facilitate a higher level of fluid absorption yet retain slightly elevated levels of Cl, we sought to evaluate the capacity of CF and non-CF airways to absorb both 22Na and 36Cl. Two consistent findings were evident from these studies. First, in both CF and non-CF xenografts, 22Na and 36Cl were always absorbed in an equal molar ratio. Second, CF xenografts hyperabsorbed ( approximately 1.5-fold higher) both 22Na and 36Cl compared with non-CF xenografts. These results substantiate previously documented findings of elevated Na absorption in CF airways and also suggest that the slightly elevated [Cl]s found in this study of CF xenograft epithelia does not occur through a mechanism of decreased apical permeability to Cl. PMID- 9950777 TI - Adenylyl cyclase P-site ligands accelerate differentiation in Ob1771 preadipocytes. AB - Differentiation of Ob1771 preadipocytes to adipocytes was characterized by morphological changes and elevated expression of the specific marker enzyme, glycerol-3-phosphate dehydrogenase. A differentiation response substantially more complete and rapid than that obtained with insulin and 3,5,3'-triiodothyronine was observed with established inhibitors of adenylyl cyclases: 2', 5' dideoxyadenosine (2',5'-dd-Ado), 9-(cyclopentyl)adenine (9-CP-Ade), and 9 (arabinofuranosyl)adenine (9-Ara-Ade), coincident with decreased cellular cAMP levels. These ligands inhibit adenylyl cyclases noncompetitively, via a domain referred to as the P-site because of its requirement for an intact purine moiety. Differentiation was not induced by inosine, a nucleoside known not to act at the P-site, or by N6-(2-phenylisopropyl)adenosine or 1, 3-diethyl-8-phenylxanthine, agonist and antagonist, respectively, for adenosine A1 receptors. Also ineffective were IBMX or forskolin, agents that can raise intracellular cAMP levels. Potency of the differentiation response followed the order 2',5'-dd-Ado (1-20 microM) > 9-CP-Ade (10-100 microM) = 9-Ara-Ade (10-100 microM) >> inosine, consistent with their potencies to inhibit adenylyl cyclases. The data suggest that inhibition of adenylyl cyclase via the P-site and the consequent reduction in cell cAMP levels facilitate the induction of differentiation in Ob1771 cells. The findings raise the question whether the known endogenous P-site ligands participate in the differentiation response induced by hormones. PMID- 9950776 TI - Intracellular H+ regulates the alpha-subunit of ENaC, the epithelial Na+ channel. AB - Protons regulate electrogenic sodium absorption in a variety of epithelia, including the cortical collecting duct, frog skin, and urinary bladder. Recently, three subunits (alpha, beta, gamma) coding for the epithelial sodium channel (ENaC) were cloned. However, it is not known whether pH regulates Na+ channels directly by interacting with one of the three ENaC subunits or indirectly by interacting with a regulatory protein. As a first step to identifying the molecular mechanisms of proton-mediated regulation of apical membrane Na+ permeability in epithelia, we examined the effect of pH on the biophysical properties of ENaC. To this end, we expressed various combinations of alpha-, beta-, and gamma-subunits of ENaC in Xenopus oocytes and studied ENaC currents by the two-electrode voltage-clamp and patch-clamp techniques. In addition, the effect of pH on the alpha-ENaC subunit was examined in planar lipid bilayers. We report that alpha,beta,gamma-ENaC currents were regulated by changes in intracellular pH (pHi) but not by changes in extracellular pH (pHo). Acidification reduced and alkalization increased channel activity by a voltage independent mechanism. Moreover, a reduction of pHi reduced single-channel open probability, reduced single-channel open time, and increased single-channel closed time without altering single-channel conductance. Acidification of the cytoplasmic solution also inhibited alpha, beta-ENaC, alpha,gamma-ENaC, and alpha ENaC currents. We conclude that pHi but not pHo regulates ENaC and that the alpha ENaC subunit is regulated directly by pHi. PMID- 9950778 TI - GAIP, a Galphai-3-binding protein, is associated with Golgi-derived vesicles and protein trafficking. AB - Proteins of the regulators of G protein signaling (RGS) family bind to Galpha subunits to downregulate their signaling in a variety of systems. Galpha interacting protein (GAIP) is a mammalian RGS protein that shows high affinity for the activated state of Galphai-3, a protein known to regulate post-Golgi trafficking of secreted proteins in kidney epithelial cells. This study aimed to localize GAIP in epithelial cells and to investigate its potential role in the regulation of membrane trafficking. LLC-PK1 cells were stably transfected with a c-myc-tagged GAIP cDNA. In the transfected and untransfected cells, GAIP was found in the cytosol and on cell membranes. Immunogold labeling showed that membrane-bound GAIP was localized on budding vesicles around Golgi stacks. When an in vitro assay was used to generate vesicles from isolated rat liver and Madin Darby canine kidney cell Golgi membranes, GAIP was found to be concentrated in fractions of newly budded Golgi vesicles. Finally, the constitutive trafficking and secretion of sulfated proteoglycans was measured in cell lines overexpressing GAIP. We show evidence for GAIP regulation of secretory trafficking before the level of the trans-Golgi network but not in post-Golgi secretion. The location and functional effects of GAIP overlap only partially with those of Galphai-3 and suggest multiple roles for GAIP in epithelial cells. PMID- 9950779 TI - Glucose induces an acute increase of superoxide dismutase activity in incubated rat pancreatic islets. AB - The activity of superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSP) in isolated rat pancreatic islets exposed to high glucose concentration for a short period of time (60 min) was determined. High glucose concentration (16.7 mM) did not significantly alter catalase activity. GSP activity was increased by glucose at 5.6 mM, remaining elevated at higher concentrations up to 16.7 mM. However, the activity of SOD increased with glucose concentration, and this increment was closely correlated with the rate of insulin secretion (r = 0.96). High potassium (30 mM) did not increase SOD activity, suggesting that the increase in intracellular ionic calcium concentration does not stimulate this enzyme activity. alpha-Ketoisocaproic acid and pyruvate, which are metabolized through the TCA cycle, did not increase SOD activity, indicating that the stimulation of SOD activity might be triggered by a factor produced through glycolysis or the pentose phosphate pathway. PMID- 9950780 TI - The endocrine secretion of mammalian digestive enzymes by exocrine glands. AB - The exocrine pancreas and certain salivary glands of mammals secrete a variety of enzymes into the gastrointestinal tract, where they digest food. The same glands also release these enzymes into the bloodstream. This latter process has commonly been assumed to occur solely as the result of a pathological condition or as an inadvertent by-product of exocrine secretion due to the leakage of trace quantities of the enzymes into blood. However, a variety of evidence suggests that the endocrine secretion of digestive enzymes is a normal occurrence that can be of substantial magnitude in healthy individuals, is responsive to various physiological stimuli, and is distinct from exocrine secretion. Recent research has focused attention on this process as a promising means for the delivery of engineered proteins into the systemic circulation for pharmaceutical purposes. In this review, we survey research in this area and consider the evidence for the existence of an endocrine secretion of digestive enzymes, the cause of enzyme release into the bloodstream, its source within the tissue, and, finally, the physiological purposes that this secretion process might serve. PMID- 9950781 TI - Glycerol and nonesterified fatty acid metabolism in human muscle and adipose tissue in vivo. AB - To determine the relationship between glycerol and nonesterified fatty acid (NEFA) release from adipose tissue, and to test whether forearm muscle and abdominal adipose tissue are capable of extracting these two lipolytic products from the circulation, 13 male subjects were studied after an overnight fast during combined infusion of radiolabeled palmitate and glycerol. Blood samples were taken from a radial artery, a deep forearm vein, and a superficial abdominal vein before and during a 2-h infusion of glucose at approximately 7 mg. kg-1. min 1. The ratio of the appearance rates of total NEFA to glycerol was approximately 3/1 during the baseline period but decreased to 1.3/1 during glucose infusion. There was significant extraction of both glycerol and NEFA by forearm muscle. In contrast, there was no apparent uptake of glycerol by adipose tissue. Adipose tissue NEFA uptake was undetectable during the baseline period but became significant during glucose infusion. These data indicate that there is very little to no in situ reesterification of NEFA in adipose tissue after an overnight fast. During glucose infusion, there was apparently a relative increase in the fraction of glycerol derived from the action of lipoprotein lipase and an increase in reesterification in situ. PMID- 9950782 TI - Effects of an oral and intravenous fat load on adipose tissue and forearm lipid metabolism. AB - We have studied the fate of lipoprotein lipase (LPL)-derived fatty acids by measuring arteriovenous differences across subcutaneous adipose tissue and skeletal muscle in vivo. Six subjects were fasted overnight and were then given 40 g of triacylglycerol either orally or as an intravenous infusion over 4 h. Intracellular lipolysis (hormone-sensitive lipase action; HSL) was suppressed after both oral and intravenous fat loads (P < 0.001). Insulin, a major regulator of HSL activity, showed little change after either oral or intravenous fat load, suggesting that suppression of HSL action occurred independently of insulin. The rate of action of LPL (measured as triacylglycerol extraction) increased with both oral and intravenous fat loads in adipose tissue (P = 0.002) and skeletal muscle (P = 0.001). There was increased escape of LPL-derived fatty acids into the circulation from adipose tissue, shown by lack of reesterification of fatty acids. There was no release into the circulation of LPL-derived fatty acids from skeletal muscle. These results suggest that insulin is not essential for HSL suppression or increased triacylglycerol clearance but is important in reesterification of fatty acids in adipose tissue but not uptake by skeletal muscle, thus affecting fatty acid partitioning between adipose tissue and the circulation, postprandial nonesterified fatty acid concentrations, and hepatic very low density lipoprotein secretion. PMID- 9950783 TI - Thermoregulatory and soporific effects of very low dose melatonin injection. AB - The effect of a rapid increase in circulating melatonin on body temperatures and sleepiness was investigated in eight young adults at 1000. Melatonin administered intravenously at 10- and 30-microgram doses, but not 3 microgram, resulted in elevated plasma and saliva levels consistent with endogenous levels measured in adults at night. Melatonin at 10 and 30 microgram significantly attenuated the daytime increase in rectal core temperature (P < 0.05 for both). The mean maximum rectal core temperature differences between saline and melatonin treatment were 0.11 +/- 0.03 degreesC, 0.16 +/- 0.04 degreesC, and 0.18 +/- 0.04 degreesC after the 3-, 10-, and 30-microgram melatonin doses, respectively. All three doses significantly increased hand temperature compared with saline (P < 0. 05) within 30 min. The mean maximum hand temperature differences were 0.72 +/- 0.12 degreesC (3 microgram), 0.95 +/- 0.15 degreesC (10 microgram), and 0.65 +/- 0.11 degreesC (30 microgram). Foot temperature and subjective sleepiness measures did not change at any melatonin dose. The results suggest that daytime intravenous injection of melatonin to achieve normal nocturnal levels in young adults may produce significant thermoregulatory changes without soporific effects. PMID- 9950784 TI - Effect of high-intensity exercise training on lactate/H+ transport capacity in human skeletal muscle. AB - The present study examined the effect of high-intensity exercise training on muscle sarcolemmal lactate/H+ transport and the monocarboxylate transporters (MCT1 and MCT4) as well as lactate and H+ release during intense exercise in humans. One-legged knee-extensor exercise training was performed for 8 wk, and biopsies were obtained from untrained and trained vastus lateralis muscle. The rate of lactate/H+ transport determined in sarcolemmal giant vesicles was 12% higher (P < 0.05) in the trained than in untrained muscle (n = 7). The content of MCT1 and MCT4 protein was also higher (76 and 32%, respectively; n = 4) in trained muscle. Release of lactate and H+ from the quadriceps muscle at the end of intense exhaustive knee-extensor exercise was similar in the trained and untrained leg, although the estimated muscle intracellular-to-interstitial gradients of lactate and H+ were lower (P < 0.05) in the trained than in the untrained muscle. The present data show that intense exercise training can increase lactate/H+ transport capacity in human skeletal muscle as well as improve the ability of the muscle to release lactate and H+ during contractions. PMID- 9950786 TI - Dexamethasone inhibits small intestinal growth via increased protein catabolism in neonatal pigs. AB - Our objective was to determine how dexamethasone (Dex) affects gastrointestinal protein metabolism and growth in neonatal pigs. Two-day-old pigs were given daily subcutaneous injections of either Dex (1 mg/kg body wt, n = 7) or saline (control, n = 6) for 7 days. In vivo protein synthesis was measured after 7 days with a bolus of [3H]phenylalanine. Tissue protein contents were measured in an initial control group of 2-day-old pigs and in control and Dex pigs after 7 days to estimate protein accretion and degradation. In control pigs, the protein accretion in the ileum was nearly sixfold greater than in the jejunum during the 7-day period. Dex nominally altered stomach growth but completely blocked the accretion of protein and DNA in the jejunum and ileum, with reduced villus height in the ileum. Dex increased the fractional protein degradation rate in the ileum (28%) and decreased the absolute protein synthesis rate in the jejunum and ileum by 17 and 21%, respectively. Dex resulted in a 40% lower total intestinal lactase activity compared with controls via reductions in both specific activity and tissue mass, especially in the ileum. Dex significantly decreased the circulating concentrations of insulin-like growth factor (IGF) I and IGF-binding protein (IGFBP)-1, -2, and -3. However, the tissue abundance of the IGF-I receptor in the stomach and ileum was greater in Dex pigs than controls. Our results suggest that Dex significantly inhibits small intestinal growth via both increased degradation and decreased synthesis of protein. Furthermore, the inhibition of intestinal growth resulted in significantly decreased lactose digestive capacity. PMID- 9950785 TI - Proinsulin stimulates growth of small intestinal crypt-like cells acting via specific receptors. AB - The mechanisms that regulate cell turnover in the intestinal epithelium are incompletely understood. Here we tested the hypothesis that proinsulin, present in serum and pancreatic juice in picomolar concentrations, stimulates growth of the rat small intestinal crypt-like cell line IEC-6 under serum-free conditions. Proinsulin binding was assessed by competitive ligand binding studies. Proinsulin and insulin-like growth factor I (IGF-I) stimulated cell proliferation up to threefold above controls, with half-maximal action already in the picomolar range and with additive effects. In early confluent cell monolayers, proinsulin bound with higher affinity (IC50 1.3 +/- 0.05 nM) and capacity (87,200 +/- 2,500 receptors/cell) than IGF-I (4.0 +/- 0.6; 23,700 +/- 2,200, P < 0. 05). C-peptide competed with 10-fold lower affinity for binding of 125I-proinsulin but not for 125I-IGF-I or 125I-insulin, suggesting a specific binding epitope of the proinsulin molecule within or close to the C-peptide region. In contrast, insulin showed approximately 100-fold lower binding affinity and growth-promoting potency than proinsulin or IGF-I. We conclude that proinsulin stimulates growth of small intestinal crypt cells through specific binding and may play a physiological role in the regulation of intestinal epithelial cell proliferation. PMID- 9950787 TI - Effect of short-term fasting on lipid kinetics in lean and obese women. AB - We evaluated whole body and regional adipose tissue lipid kinetics and norepinephrine (NE) spillover during brief fasting in six lean [body mass index (BMI) 21 +/- 1 kg/m2] and six upper-body obese (UBO; BMI 36 +/- 1 kg/m2) women. At 14 h of fasting, abdominal adipose tissue glycerol and free fatty acid (FFA) release rates were lower (P = 0.07), but whole body glycerol and FFA rates of appearance (Ra) were greater (P < 0.05) in obese than in lean subjects. At 22 h of fasting, glycerol and FFA Ra increased less in obese (19.8 +/- 7.0 and 87.1 +/ 30.3 micromol/min, respectively) than in lean (44.2 +/- 6.6 and 137.4 +/- 30.4 micromol/min, respectively; P < 0.05) women. The percent increase in glycerol Ra correlated closely with the percent decline in plasma insulin in both groups (r2 = 0.85; P < 0.05). Whole body NE spillover declined in lean (P < 0.05) but not obese subjects with continued fasting, whereas regional adipose tissue NE spillover did not change in either group. We conclude that, compared with lean women, in UBO women 1) basal adipose tissue lipolysis is lower, but whole body lipid kinetics is higher because of their greater fat mass; 2) the increase in lipolysis during fasting is blunted because of an attenuated decline in circulating insulin; and 3) downregulation of whole body sympathetic nervous system activity is impaired during fasting. PMID- 9950788 TI - Glucose production during an IVGTT by deconvolution: validation with the tracer to-tracee clamp technique. AB - Recently, a new method, based on a two-compartment minimal model and deconvolution [A. Caumo and C. Cobelli. Am. J. Physiol 264 (Endocrinol. Metab. 37): E829-E841, 1993; P. Vicini, G. Sparacino, A. Caumo, and C. Cobelli. Comput. Meth. Prog. Biomed. 52: 147-156, 1997], has been proposed to estimate endogenous glucose production (EGP) from labeled intravenous glucose tolerance test (IVGTT) data. Our aim here is to compare this EGP profile with that independently obtained with the reference method, based on the tracer-to-tracee ratio (TTR) clamp. An insulin-modified (0.03 U/kg body wt infused over 5 min) [6,6 2H2]glucose-labeled IVGTT (0.33 g/kg of glucose) was performed in 10 normal subjects. A second tracer ([U-13C]glucose) was also infused during the test in a variable fashion to clamp endogenous glucose TTR. The TTR clamp was quite successful. As a result, the EGP profile, reconstructed from [U-13C]glucose data with the models of Steele and Radziuk, were almost superimposable. The deconvolution-obtained EGP profile, calculated from [6,6-2H2]glucose data, showed remarkable agreement with that obtained from the TTR clamp. Some differences between the two profiles were noted in the estimated basal EGP and in the initial modalities of EGP inhibition. A high interindividual variability was also observed with both methods in the resumption of EGP to baseline; variability was high in both the timing and the extent of resumption. In conclusion, the use of the two-compartment minimal model of the IVGTT and deconvolution allows the estimation of a profile of EGP that is in very good agreement with that independently obtained with a TTR clamp. PMID- 9950789 TI - Differential effect of amino acid infusion route on net hepatic glucose uptake in the dog. AB - Concomitant portal infusion of gluconeogenic amino acids (GNGAA) and glucose significantly reduces net hepatic glucose uptake (NHGU), in comparison with NHGU during portal infusion of glucose alone. To determine whether this effect on NHGU is specific to the portal route of GNGAA delivery, somatostatin, intraportal insulin (3-fold basal) and glucagon (basal), and intraportal glucose (to increase the hepatic glucose load by approximately 50%) were infused for 240 min. GNGAA were infused peripherally into a group of dogs (PeAA), at a rate to match the hepatic GNGAA load in a group of dogs that were given the same GNGAA mixture intraportally (PoAA) at 7.6 micromol. kg-1. min-1 (9). The arterial blood glucose concentrations and hepatic glucose loads were the same in the two groups, but NHGU (-0. 9 +/- 0.2 PoAA and -2.1 +/- 0.5 mg. kg-1. min-1 in PeAA, P < 0.05) and net hepatic fractional extraction of glucose (2.6 +/- 0.7% in PoAA vs. 5.9 +/- 1.4% in PeAA, P < 0.05) differed. Neither the hepatic loads nor the net hepatic uptakes of GNGAA were significantly different in the two groups. Net hepatic glycogen synthesis was approximately 2.5-fold greater in PeAA than PoAA (P < 0.05). Intraportal, but not peripheral, amino acid infusion suppresses NHGU and net hepatic glycogen synthesis in response to intraportal glucose infusion. PMID- 9950790 TI - Control of adrenal cell proliferation by AT1 receptors in response to angiotensin II and low-sodium diet. AB - The effects of angiotensin II (ANG II), the angiotensin type 1 (AT1) receptor antagonist losartan, and low-sodium diet on rat adrenal cell proliferation were studied in vivo with immunocytochemistry. Both ANG II and low-sodium diet increased proliferation of endothelial cells of the zona glomerulosa. Losartan prevented ANG II-induced hyperplasia of glomerulosa cells but not the effects of a low-sodium diet. Glomerulosa cells after ANG II + losartan treatment appeared hypertrophied compared with those of controls. Proliferative effects of ANG II and low-sodium diet in the reticularis were blocked by losartan. No changes were seen in the fasciculata. Proliferation in the medulla was increased with losartan, was decreased by ANG II, but was unaffected by low-sodium diet. In conclusion, 1) cell hypertrophy and proliferation of glomerulosa cells are mediated by AT1 receptor-dependent and -independent processes, 2) proliferation of reticularis cells is controlled by AT1 receptors, and 3) reciprocal control of chromaffin cell proliferation by ANG II may involve indirect AT1-dependent processes. PMID- 9950791 TI - Fas regulates germ cell apoptosis in the human testis in vitro. AB - The Fas-Fas ligand (FasL) system has been implicated in maintaining the immune privileged nature of the testis. The present report concerns the role of the Fas FasL system in regulating germ cell apoptosis, another important function of this system in the human testis. Fas was localized immunohistochemically to the same types of germ cells that were identified as apoptotic, namely spermatocytes and spermatids. Strong expression of Fas was also observed in Western blot analysis of the human testis. Furthermore, an antagonistic antibody to the FasL blocked germ cell apoptosis induced in vitro by incubating segments of seminiferous tubules under serum- and hormone-free conditions (i.e., without survival factors). Thus Fas appears to mediate germ cell apoptosis. A universal caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone, also inhibited germ cell death, suggesting that Fas-associated germ cell apoptosis is mediated via the caspase pathway. The present results suggest an important role for the Fas-FasL system in the regulation of germ cell apoptosis in the human testis. PMID- 9950792 TI - Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals. AB - We investigated prospectively the effect of sex steroids on regional fat depots and thigh muscle mass in adult transsexuals. Ethinyl estradiol in combination with cyproterone acetate, a progestational antiandrogen, was given to 20 male-to female (M-F) transsexuals, and parenteral testosterone esters were given to 17 female-to-male (F-M) transsexuals. Before and after 12 mo of cross-sex hormone administration, several anthropometric measurements (weight, skinfolds, body circumferences, and bioimpedance) were performed, and transverse magnetic resonance images were obtained at the level of the abdomen, hip, and thigh to quantify fat depots (subcutaneous and visceral) and muscle areas. We observed that treatment with ethinyl estradiol in M-F transsexuals induced a significant increase in all subcutaneous fat depots, with a lesser but proportional and significant increase in the visceral fat depot and a decrease in thigh muscle area. Testosterone administration in F-M transsexuals markedly increased thigh muscle area, reduced subcutaneous fat deposition at all levels measured, but slightly increased the visceral fat area. We conclude that sex steroid hormones are important determinants of the sex-specific localization of body fat. PMID- 9950793 TI - Mechanisms involved in the regulation of key enzymes of cysteine metabolism in rat liver in vivo. AB - Little is known about mechanisms of regulation of cysteine dioxygenase (CDO), gamma-glutamylcysteine synthetase (GCS), and cysteine-sulfinate decarboxylase (CSDC) in response to diet. Enzyme activity and Western and Northern or dot blot analyses were conducted on liver samples from rats fed a basal low-protein diet or diets with graded levels of protein or methionine for 2 wk. Higher levels of CDO activity and CDO protein but not of CDO mRNA were observed in liver of rats fed methionine or protein-supplemented diets, indicating that CDO activity is regulated by changes in enzyme concentration. Lower concentrations of the heavy or catalytic subunit of GCS (GCS-HS) mRNA and protein, as well as a lower activity state of GCS-HS in rats fed methionine- or protein-supplemented diets, indicated that dietary regulation of GCS occurs by both pretranslational and posttranslational mechanisms. Lower CSDC activity, CSDC protein concentration, and CSDC mRNA concentration were found in rats fed the highest level of protein, and regulation appeared to involve changes in mRNA concentration. Regulation of key enzymes of cysteine metabolism in response to diet determines the use of cysteine for synthesis of its essential metabolites. PMID- 9950794 TI - Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein. AB - Type C Niemann-Pick disease is due to a mutation in Niemann-Pick C (NPC) protein, a putative determinant of intracellular cholesterol transport. This study quantifies cholesterol balance in vivo across all tissues in mice with this defect. Cholesterol balance in the heterozygous animal is normal, but in the homozygous mouse the whole animal cholesterol pool expands continuously from birth, reaching 5, 442 mg/kg at 7 wk. The size of this pool in each organ is proportional to the rate at which each tissue clears low-density lipoprotein cholesterol. Despite this expansion, however, cholesterol synthesis is increased so that whole animal synthesis equals 180 mg. day-1. kg-1. Forcing additional cholesterol into the liver through the clathrin-coated pit pathway increases the hepatic cholesterol pool in control mice, all of which is esterified, while there is a much greater increase in this pool in mutant mice, all of which is unesterified. These findings are consistent with the view that there is a block in sterol movement from the lysosome to the sites of regulation in NPC disease and have important implications for understanding the function of the NPC protein in intracellular cholesterol metabolism, in general, and in the brain, in particular. PMID- 9950795 TI - Oxytocin increases the [Ca2+]i sensitivity of human myometrium during the falling phase of phasic contractions. AB - Oxytocin is commonly used to induce or augment labor, but its mode of action is uncertain. To address the issue, isometric tension and the intracellular free Ca2+ concentration ([Ca2+]i) were simultaneously recorded from isolated strips of pregnant human myometrium loaded with fura 2. The changes in [Ca2+]i and tension during phasic contractions were indistinguishable in myometrium taken before or after the onset of labor, enabling samples to be pooled. Oxytocin (10 nM) had no effect on basal [Ca2+]i or tension, but it increased both the [Ca2+]i and the tension recorded during phasic contractions. Analysis of the [Ca2+]i-tension relationship revealed that during the falling (relaxation) phase of the contractile response, oxytocin increased the tension recorded at each [Ca2+]i. By manipulating extracellular Ca2+ during phasic contractions, it was possible to ensure that the [Ca2+]i signals were similar in the presence and absence of oxytocin, yet oxytocin still improved the [Ca2+]i-tension relationship. We conclude that 10 nM oxytocin increases the [Ca2+]i sensitivity of the contractile proteins only after a contraction has begun, possibly by causing inhibition of myosin light chain phosphatase. PMID- 9950796 TI - Muscular long-chain fatty acid content during graded exercise in humans. AB - We measured the content of long-chain fatty acids (LCFA) in biopsies obtained from the vastus lateralis muscle in humans at rest and after different exercise intensities. Nine volunteers exercised at 65% of maximal oxygen uptake (VO2 max) for 40 min and at 90% of VO2 max for another 15 min on a Krogh bicycle ergometer. LCFA measured in muscle tissue averaged 76 +/- 5 nmol/g wet wt at rest, decreased significantly after exercise at 65% VO2 max to 48 +/- 4 nmol/g wet wt, and increased to 68 +/- 5 nmol/g wet wt (P < 0.05) after high-intensity exercise. The calculated myocyte LCFA content at rest amounted to 69 +/- 5 nmol/g wet wt, decreased by 43% (P < 0.05) after exercise at 65% of VO2 max, and subsequently increased by 54% after exercise at 90% of VO2 max (P < 0.05) compared with the values obtained at the lower workload. The blood plasma LCFA concentration during the low-intensity exercise (366 +/- 23 nmol/ml) was similar to the values obtained at rest (372 +/- 31 nmol/ml) but decreased significantly during the high intensity workload (249 +/- 49 nmol/ml). From these data it is proposed that 1) in human skeletal muscle, metabolism rather than cellular availability of LCFA governs the rate of LCFA utilization at rest and during exercise, and 2) consequently reduction in muscle LCFA oxidation during high-intensity exercise (e.g., 90% VO2 max) is due primarily to a decrease in mitochondrial LCFA oxidation rate rather than an insufficient cellular availability of LCFA. PMID- 9950797 TI - Plasma insulin rise precedes rise in ob mRNA expression and plasma leptin in gold thioglucose-obese mice. AB - Circulating leptin levels are strongly related to the degree of adiposity, with hyperleptinemia being associated with hyperinsulinemia. In the gold thioglucose injected mouse (GTG), hyperinsulinemia is an early abnormality in the development of insulin resistance and obesity. In this study, hyperinsulinemia occurred 1 wk post-GTG [GTG, 199 +/- 43; age-matched controls (CON), 53 +/- 5 microU/ml; P < 0.001], with leptin levels not rising until 2 wk post-GTG (CON, 3.2 +/- 0.3; GTG, 9.9 +/- 1.7 ng/ml; P < 0.001) in parallel with increases in the size of different fat pads and increased expression of ob mRNA. The ratio of serum leptin to fat pad weight was significantly higher in GTG mice 12 wk postinjection. Starvation induced reductions in serum leptin (50%), glucose (50%), and insulin (74%) were greater than decreases in fat pad weight (18%). Adrenalectomy decreased both adiposity and serum leptin within 1 wk in both CON and GTG and altered the serum leptin level-to-fat pad weight ratio in CON. Thus hyperinsulinemia preceded increased ob expression and hyperleptinemia, which occurred in parallel with increasing adiposity, consistent with the role of leptin as an indicator of energy supplies. Changes in hormonal and nutritional status may modify this relationship. PMID- 9950798 TI - Discrimination, adjusted correlation, and equivalence of imprecise tests: application to glucose tolerance. AB - Comparison studies between physiological tests are often unsatisfactory for assessing their ability to distinguish between subjects. We recommend a simple but comprehensive protocol, using duplicate testing, that compares tests using 1) the discriminant ratio (DR) between the underlying between- and within-subject SDs, 2) correlation coefficients adjusted for attenuation due to test imprecision, and 3) unbiased estimation of the underlying linear relationship between test results. The following five alternative methods for assessing glucose tolerance were compared: fasting plasma glucose (FPG) as a single sample or as the mean of three 5-min samples (FPG3); the 1- and 2-h glucose during a low dose intravenous glucose infusion (CIG); and the 2-h plasma glucose from a 75-g oral glucose tolerance test (OGTT). All tests had similar DRs ranging from 2.6 to 4.2. The adjusted correlation between FPG and CIG tests approached unity, and those between OGTT and other tests were approximately 0.9, showing that FPG3 provides similar information to the OGTT. FPG concentrations of 6.0 and 7.1 were found equivalent to the 1985 World Health Organization OGTT thresholds for impaired glucose tolerance and diabetes (7.8 and 11.1 mmol/l). PMID- 9950799 TI - The anabolic effect of PGE2 in rat bone marrow cultures is mediated via the EP4 receptor subtype. AB - Prostaglandin E2 (PGE2) is an anabolic agent in vivo that stimulates bone formation by recruiting osteoblasts from bone marrow precursors. To understand which of the known PGE2 receptors (EP1-4) is involved in this process, we tested the effect of PGE2 and various EP agonists and/or antagonists on osteoblastic differentiation in cultures of bone marrow cells by counting bone nodules and measuring alkaline phosphatase activity. PGE2 increased both parameters, peaking at 100 nM, an effect that was mimicked by forskolin and was abolished by 2',3' dideoxyadenosine (an adenylate cyclase inhibitor) and was thus cAMP dependent, pointing to the involvement of EP2 or EP4. Consistently, 17-phenyl-omega-trinor PGE2 (EP1 agonist) and sulprostone (EP3/EP1 agonist) lacked any anabolic activity. Furthermore, butaprost (EP2 agonist) was inactive, 11-deoxy-PGE1 (EP4/EP2 agonist) was as effective as PGE2, and the PGE2 effect was abolished dose dependently by the selective EP4 antagonist AH-23848B, suggesting the involvement of EP4. We also found that PGE2 increased nodule formation and AP activity when added for the initial attachment period of 24 h only. Thus this study shows that PGE2 stimulates osteoblastic differentiation in bone marrow cultures, probably by activating the EP4 receptor, and that this effect may involve recruitment of noncommitted (nonadherent) osteogenic precursors, in agreement with its suggested mode of operation in vivo. PMID- 9950800 TI - Pre-beta-HDL stimulates placental lactogen release from human trophoblast cells. AB - To examine whether pre-beta-high-density lipoprotein (HDL) may be involved in regulation of human placental lactogen (hPL) release, pre-beta-HDL was isolated from term pregnancy serum, and the effect of purified pre-beta-HDL on hPL release from trophoblast cells was examined after 1 h of exposure. Pre-beta-HDL stimulated a dose-dependent increase in hPL release with half-maximal stimulation at a dose of 300-400 microgram/ml, which is within the normal physiological range during pregnancy. Analysis of pre-beta-HDL and alpha-HDL in serum from pregnant women at different stages of gestation (determined by Western blot analysis) indicated that the pre-beta-HDL-to-alpha-HDL ratio increased linearly after the 10th week of gestation (r = 0.88, P < 0.001), reaching a maximum sixfold greater than that of nonpregnant women. The increase in serum pre-beta-HDL during pregnancy paralleled that of plasma hPL concentrations (r = 0.93, P < 0.001). Two dimensional electrophoresis indicated that the increase in pre-beta-HDL was due primarily to an increase in pre-beta1-HDL and pre-beta2-HDL, two of the three forms of pre-beta-HDL present in blood. These results suggest a role for pre-beta HDL in the regulation of hPL expression during pregnancy. PMID- 9950801 TI - GLUT-1 or GLUT-4 transgenes in obese mice improve glucose tolerance but do not prevent insulin resistance. AB - Insulin-stimulated glucose uptake is defective in patients with type 2 diabetes. To determine whether transgenic glucose transporter overexpression in muscle can prevent diabetes induced by a high-fat, high-sugar diet, singly (GLUT-1, GLUT-4) and doubly (GLUT-1 and -4) transgenic mice were placed on a high-fat, high-sugar diet or a standard chow diet. On the high-fat, high-sugar diet, wild-type but not transgenic mice developed fasting hyperglycemia and glucose intolerance (peak glucose of 337 +/- 19 vs. 185-209 mg/dl in the same groups on the high-fat, high sugar diet and 293 +/- 13 vs. 166-194 mg/dl on standard chow). Hyperinsulinemic clamps showed that transporter overexpression elevated insulin-stimulated glucose utilization on standard chow (49 +/- 4 mg. kg-1. min-1 in wild-type vs. 61 +/- 4, 67 +/- 5, and 63 +/- 6 mg. kg-1. min-1 in GLUT-1, GLUT-4, and GLUT-1 and -4 transgenic mice given 20 mU. kg-1. min-1 insulin, and 54 +/- 7, 85 +/- 4, and 98 +/- 11 in wild-type, GLUT-1, and GLUT-4 mice given 60-80 mU. kg-1. min-1 insulin). On the high-fat, high-sugar diet, wild-type and GLUT-1 mice developed marked insulin resistance, but GLUT-4 and GLUT-1 and -4 mice were somewhat protected (glucose utilization during hyperinsulinemic clamp of 28.5 +/- 3.4 vs. 42.4 +/- 5.9, 51.2 +/- 8.1, and 55.9 +/- 4. 9 mg. kg-1. min-1 in wild type, GLUT 1, GLUT-4, GLUT-1 and -4 mice). These data demonstrate that overexpression of GLUT-1 and/or GLUT-4 enhances whole body glucose utilization and prevents the development of fasting hyperglycemia and glucose intolerance induced by a high fat, high-sugar diet. GLUT-4 overexpression improves the insulin resistance induced by the diet. We conclude that upregulation of glucose transporters in skeletal muscle may be an effective therapeutic approach to the treatment of human type 2 diabetes. PMID- 9950802 TI - Direct access to interstitial fluid in adipose tissue in humans by use of open flow microperfusion. AB - To gain direct access to the interstitial fluid (ISF), a new technique called open-flow microperfusion has been evaluated. This method is based on a double lumen catheter with macroscopic (0.3-0.5 mm diameter) perforations that is inserted into the subcutaneous adipose tissue and constantly perfused. Thus partial equilibration between the ISF and the perfusion fluid occurs. The glucose concentration of the ISF was determined by established (zero flow rate, no net flux, and recirculation procedures) and new (ionic reference and suction technique) calibration methods by use of open-flow microperfusion. The data show that 1) the glucose concentration in the ISF is significantly lower than the corresponding arterialized venous plasma values during basal steady-state conditions (adipose tissue 3.2 +/- 0.10 mM, plasma 5.27 +/- 0.12 mM) as well as during hyperglycemic clamp experiments (adipose tissue 7.3 +/- 0.13 mM, plasma 9.91 +/- 0.16 mM), and 2) it is possible to determine the recovery continuously by using the ion concentration of the ISF as an internal standard (ionic reference). PMID- 9950803 TI - Genetic disorders of membrane transport. IV. Wilson's disease and Menkes disease. AB - Copper is an essential transition metal that permits the facile transfer of electrons in a series of critical biochemical pathways. Menkes disease and Wilson's disease are inherited disorders of copper metabolism resulting from the absence or dysfunction of homologous copper-transporting ATPases that reside in the trans-Golgi network of all cells. Despite striking differences in the clinical presentation of these two diseases, the respective ATPases function in precisely the same manner within the cell and the unique clinical features of each disease are entirely the result of the tissue-specific expression of each protein. Elucidation of the basic defect in these rare genetic disorders has provided a valuable heuristic paradigm for understanding the mechanisms of cellular copper homeostasis. PMID- 9950804 TI - Nitric oxide. I. Physiological chemistry of nitric oxide and its metabolites:implications in inflammation. AB - The role of nitric oxide (NO) in inflammation represents one of the most studied yet controversial subjects in physiology. A number of reports have demonstrated that NO possesses potent anti-inflammatory properties, whereas an equally impressive number of studies suggest that NO may promote inflammation-induced cell and tissue dysfunction. The reasons for these apparent paradoxical observations are not entirely clear; however, we propose that understanding the physiological chemistry of NO and its metabolites will provide a blueprint by which one may distinguish the regulatory/anti-inflammatory properties of NO from its deleterious/proinflammatory effects. The physiological chemistry of NO is complex and encompasses numerous potential reactions. In an attempt to simplify the understanding of this chemistry, the physiological aspects of NO chemistry may be categorized into direct and indirect effects. This type of classification allows for consideration of timing, location, and rate of production of NO and the relevant targets likely to be affected. Direct effects are those reactions in which NO interacts directly with a biological molecule or target and are thought to occur under normal physiological conditions when the rates of NO production are low. Generally, these types of reactions may serve regulatory and/or anti inflammatory functions. Indirect effects, on the other hand, are those reactions mediated by NO-derived intermediates such as reactive nitrogen oxide species derived from the reaction of NO with oxygen or superoxide and are produced when fluxes of NO are enhanced. We postulate that these types of reactions may predominate during times of active inflammation. Consideration of the physiological chemistry of NO and its metabolites will hopefully allow one to identify which of the many NO-dependent reactions are important in modulating the inflammatory response and may help in the design of new therapeutic strategies for the treatment of inflammatory tissue injury. PMID- 9950805 TI - Epithelial injury induces egr-1 and fos expression by a pathway involving protein kinase C and ERK. AB - The signaling pathways activated in response to gastrointestinal injury remain poorly understood. Previous work has implicated the extracellular signal regulated kinase (ERK) mitogen-activated protein kinase as a mediator of wound signal transduction and a possible regulator of epithelial restitution. Monolayer injury resulted in rapid activation of p42 and p44 ERK. Injury-induced ERK activation was blocked by protein kinase C inhibition or by disruption of the cell cytoskeleton. Significant increases in Fos and early growth response (Egr)-1 mRNA levels were stimulated by injury, peaking by 20 min. ERK activation and the induction of Egr-1 mRNA were inhibited in a dose-dependent fashion with PD-98059. Fos mRNA expression was partially blocked by PD-98059. Western blot analysis demonstrated strong expression and nuclear localization of Fos and Egr after wounding. Electrophoretic mobility shift assays demonstrated that nuclear extracts contained a protein that specifically bound double-stranded oligonucleotides containing the Egr consensus binding element. Gel supershift assays demonstrated that the protein-DNA complexes were recognized by anti-Egr antibody. Inhibition of injury-induced ERK activation by PD-98059 or direct interference with Egr by expression of a dominant negative mutant led to significantly reduced in vitro monolayer restitution. PMID- 9950806 TI - Basal pressure patterns and reflexive motor responses in the human ileocolonic junction. AB - This study aimed to determine whether a sustained high-pressure zone exists at the human ileocolonic junction (ICJ) and whether the motor responses of ICJ are consistent with sphincteric function. In 10 subjects with temporary ileostomies, a high-pressure zone was identified using a manometric pull-through with a mean pressure of 9. 7 +/- 3.2 mmHg and length of 4.8 +/- 1.2 cm. Prolonged recordings using a sleeve sensor confirmed sustained tone in the ICJ and superimposed phasic pressure waves (4-8 counts/min) occupying 35% of fasted state. A meal increased ICJ tone (P = 0.0001) and the proportion of time occupied by phasic activity to 50% (P = 0.013). Terminal ileal propagating pressure wave sequences inhibited ICJ phasic activity, and sequences not extending to the cecum reduced ICJ tone (9.0 +/- 7.2 to 5.6 +/- 6.3 mmHg; P = 0.04). Cecal distension increased ICJ tone (8.9 +/- 4.4 mmHg to 11.7 +/- 4.9 mmHg; P = 0.005). The ICJ response to ileal distension was variable and depended on resting tone at the time of distension. We conclude that the human ICJ has sustained tone with superimposed phasic activity. Tone is augmented by cecal distension or a meal and is inhibited by ileal propagating pressure waves. Response to ileal distension is variable but suggests control by descending excitatory and inhibitory pathways. PMID- 9950807 TI - Effects of systemic hypotension on postnatal intestinal circulation: role of angiotensin. AB - Systemic hypotension causes a greater degree of vasoconstriction in intestine from 3- than from 35-day-old postnatal swine. To determine the basis for this age dependent difference, systemic hypotension (pressure reduction to approximately 50% of baseline) was induced by creating pericardial tamponade in postnatal swine instrumented to allow measurement of intestinal hemodynamics and oxygenation in vivo. Hypotension caused gut vascular resistance to increase 77 +/- 6% in 3-day old subjects but only 18 +/- 3% in 35-day-old subjects. Prior blockade of alpha1 receptors with phentolamine, vasopressin receptors with [d(CH2)5,D-Phe2,Ile4,Ala9 NH2]AVP, or surgical denervation of the gut loop had no effect on hypotension induced gut vasoconstriction. Losartan, which blocks angiotensin AT1 receptors, significantly attenuated hypotension-induced gut vasoconstriction in both age groups. BQ-610, which blocks endothelin ETA receptors, also limited the magnitude of vasoconstriction but only in younger subjects. This effect may have been consequent to an interaction between endothelin and angiotensin, inasmuch as a subpressor concentration of endothelin increased the contractile response to angiotensin in mesenteric artery rings. The substantial rise in 3-day-old gut vascular resistance was partly consequent to a locally mediated vasoconstriction that occurred in response to pressure and/or flow reduction during hypotension, as evidenced by the significant attenuation of this constriction when blood flow was held constant by controlled-flow perfusion to the gut loop during hypotension. Intestinal O2 uptake was compromised to a significantly greater degree in 3- than in 35-day-old subjects during hypotension. This difference was primarily due to the inability of younger intestine to increase O2 extraction in the face of reduced blood flow and may be mediated, in part, by an effect of angiotensin II on intestinal capillary perfusion. PMID- 9950808 TI - Regulation of apolipoprotein secretion by biliary lipids in newborn swine intestinal epithelial cells. AB - Biliary lipids, composed of bile acids, cholesterol, and phosphatidylcholine, are a major source of luminal lipid in the small intestine. In the present study in a newborn swine intestinal epithelial cell line (IPEC-1), taurocholate and phosphatidylcholine were found to have no effect on apolipoprotein B (apo B) secretion but did significantly increase the basolateral secretion of apo A-I. This regulation of apo A-I secretion occurred at the pretranslational level for taurocholate and at the posttranslational level for phosphatidylcholine. The regulation of apo A-I secretion by phosphatidylcholine did not involve changes in apo A-I degradation and may involve mobilization of a preformed pool of apo A-I. Cholesterol, whether solubilized with taurocholate or phosphatidylcholine, had no effect on the secretion of either apo B or apo A-I. However, when taurocholate, phosphatidylcholine, and cholesterol were combined, apo B secretion was decreased, and the increase in apo A-I secretion noted with taurocholate and phosphatidylcholine alone was ablated. Another primary bile acid, taurochenodeoxycholate, was found to decrease apo B secretion but had no effect on apo A-I secretion. However, the significance of this effect is uncertain, since this bile acid caused significant cellular membrane injury, as evidenced by increased apical medium lactate dehydrogenase activity. Phosphatidylcholine, but not taurocholate, dramatically increased the basolateral secretion of radiolabeled phospholipid with a modest increase in cellular triglyceride radiolabeling. Furthermore, this effect of phosphatidylcholine on lipid synthesis did not require significant hydrolysis or uptake of the phosphatidylcholine molecule. Studies using radiolabeled taurocholate did not demonstrate active transport of taurocholate by these cells. PMID- 9950809 TI - Cardiac impairment and nitric oxide synthase activity in the chronic portal vein stenosed rat. AB - Decreased cardiac contractility and beta-adrenergic responses have been observed in the chronic portal vein-stenosed (PVS) rat. Because nitric oxide (NO) may be increased in PVS and has been recognized as a negative inotropic agent, we investigated the induction of NO synthase (NOS2) and/or changes in constitutive NOS (NOS3) as factors in the cardiac dysfunction of the PVS rat. Ten to twelve days after portal vein stenosis or sham operation, cardiac function was evaluated in paced left ventricular papillary muscles (LVPM) and right ventricular strips (RV). To determine if NO modulation of contractile function was altered in PVS, we examined the increase in developed tension produced by the effect of Nomega nitro-L-arginine (L-NNA) on the myocardial force-frequency relationship. Cardiac tissue NOS2 and NOS3 activities were assayed, Western blot analyses of NOS2 and NOS3 expression were performed, and circulating nitrate-nitrite (NOX) levels (an indicator of in vivo NOS activity) were assayed. Basal LVPM and RV contractile indexes were significantly reduced in PVS (30-50%), without a change in the relaxation rate. No between-group differences in the cardiac NOS2 or NOS3 enzymatic activities of PVS and sham-operated (SO) rats were observed. Western blots revealed no cardiac NOS2 expression in either SO or PVS rats. In contrast, NOS3 was expressed in both SO and PVS rats, but there was no quantitative difference in expression between the two groups. Changes in the cardiac force frequency relationship (staircase effect) after L-NNA were consistent with NOS3 modulation of contractile function in both SO and PVS rats, but there was no between-group difference in the modulation. Circulating NOX concentrations did not differ between SO and PVS rats. In conclusion, protein expression data, enzymatic assays, end-product assays, and functional data indicate that between group differences in NOS2 and NOS3 activity are not responsible for the cardiac impairment that has been observed in the chronic PVS rat. PMID- 9950810 TI - Role of nitric oxide in fasting gastric fundus tone and in 5-HT1 receptor mediated relaxation of gastric fundus. AB - Fasting gastric fundus tone is maintained by continuous cholinergic input. 5 Hydroxytryptamine-1 (5-HT1) receptor activation decreases gastric fundus tone in humans. Whether this fundus-relaxing effect is mediated via inhibition of cholinergic input or via activation of a nitrergic pathway is unknown. The aim of the present study was to determine the effect of nitrergic inhibition on feline gastric fundus tone and on 5-HT1 receptor-mediated relaxation of the fundus. Administration of Nomega-nitro-L-arginine methyl ester (L-NAME) alone caused a significant decrease of the mean baseline volume (P < 0.005), which was restored completely by addition of L-arginine. Sumatriptan caused a dose-dependent relaxation of the gastric fundus (P < 0.0005). This relaxation was inhibited by L NAME (P < 0.02) and was restored by prior administration of L-arginine. Buspirone did not cause any change in mean baseline volume, whereas the sumatriptan-induced relaxation was not affected by prior administration of NAN-190. Our data indicate that fasting fundus tone relies not only on continuous cholinergic input but also on continuous nitrergic input, implying that fasting fundus tone is maintained by the balance of a cholinergic and nitrergic drive. Furthermore, fundus relaxation via 5-HT1 receptor activation is mediated through activation of a nitrergic pathway. PMID- 9950811 TI - Prechylomicron transport vesicle: isolation and partial characterization. AB - The intestine is able to regulate its output rate of chylomicrons, the major intestinal triacylglycerol (TG) transport vehicle. We have proposed that a vesicle, transporting the developing chylomicron from the endoplasmic reticulum (ER) to the Golgi, is the rate-limiting step in the process of TG transit through the enterocyte [Am. J. Physiol. 273 (Gastrointest. Liver Physiol. 36): G18-G30, 1997]. We wished to isolate and characterize this vesicle. The apical portion of rat intestinal cells were avulsed, and the mucosa was stirred in buffer. The supernatant was centrifuged in two different sucrose gradients, and the top 2.5 ml of the last gradient were collected and concentrated. Electron microscopy showed a 200-nm vesicle. The vesicle contained immunoidentifiable apolipoprotein (apo) B48 and apo A-IV but very little apo A-I, although apo A-I was present in the ER and Golgi. [3H]TG-loaded vesicles delivered [3H]TG to the Golgi but not the ER. Marker enzyme assays also indicate that the isolated fraction is different from the ER and Golgi fractions. We conclude that we have isolated a vesicle that is post-ER but pre-Golgi that vectorially transports TG to the Golgi. PMID- 9950812 TI - Normalization of atropine-induced postprandial dysrhythmias with gastric pacing. AB - Gastric pacing has received increasing attention recently. However, few studies have systematically assessed the effect of pacing on gastric dysrhythmias. The aims of this study were to investigate the effect of gastric pacing on gastric dysrhythmia and to explore whether the effect of gastric pacing was mediated via cholinergic nerves. Eight hound dogs implanted with three pairs of serosal electrodes were studied. Three study sessions were performed on each dog. The experiment was conducted sequentially as follows: a 30-min myoelectrical recording immediately after a meal, intravenous injection of atropine or saline, and three sequential 20-min myoelectrical recordings with or without gastric pacing during the second 20-min recording. The percentage of regular slow waves (3.5-7. 0 cycles/min) was calculated using spectral analysis. The percentage of the regular slow waves was progressively reduced from 96.7 +/- 1. 7% at baseline to 29.6 +/- 9.0 (P < 0.001), 23.1 +/- 7.1 (P < 0.001), and 27.3 +/- 4.3% (P < 0.001), respectively, during the first, second, and third 20 min after atropine injection. Normalization of the gastric slow wave was achieved with gastric pacing 2.3 +/- 1.0 min after the initiation of pacing. The percentage of regular slow waves was significantly increased both during pacing (93.6 +/- 2.4 vs. 23.1 +/- 7.1%, P < 0.002) and after pacing (70.9 +/- 6.8 vs. 27. 3 +/- 4.3%, P < 0.003) in comparison with the session without pacing. We conclude that 1) atropine induces gastric myoelectric dysrhythmia in the fed state, 2) gastric pacing is able to normalize gastric postprandial dysrhythmia induced by atropine, and 3) the effect of gastric pacing is not mediated by vagal cholinergic mechanism. PMID- 9950813 TI - Slow waves in circular muscle of porcine ileum: structural and electrophysiological studies. AB - The structural and functional bases of pacemaking (slow waves) in porcine ileal circular muscle were studied. The myenteric plexus contained two, structurally distinct types of interstitial cells of Cajal (ICC) interconnected by gap junctions and connected by close contacts to muscle layers. At the deep muscular plexus, ICC were present, not regularly close to nerve axons or in gap junction contact with one another or outer circular muscle, which had many gap junctions. Slow waves (5.2 +/- 2 mV amplitude and 4.6 +/- 0.7 s duration) occurred at 9.9 +/ 1.1 counts/min. Tissue length and time constants were 2.00 +/- 0.3 mm and 111 +/ 37 ms, respectively. Large electrical field-induced hyperpolarizations or depolarizations reduced amplitudes but not frequencies or durations of slow waves; hyperpolarizations progressively reduced inhibitory junction potentials as if the K+ channel opening mediated them. In conclusion, the myenteric plexus ICC of pig ileum, which appears to pace the muscle layers, appears insensitive to voltages applied to the syncytium of circular muscle cells. Limited coupling between ICC and circular muscle or voltage-insensitive pacemaking activity may explain these findings. PMID- 9950814 TI - Bile duct cells: a novel in vitro model for the study of lipid metabolism and bile acid production. AB - Immortalized bile duct cells (BDC), derived from transgenic mice harboring the SV40 thermosensitive immortalizing mutant gene ts458, were utilized to investigate the role of the biliary epithelium in lipid and sterol metabolism. This cell model closely resembles the in vivo situation because it expresses the specific phenotypic marker cytokeratin 19 (CK-19), exhibits the formation of bile duct-like structures, and displays well-formed microvilli projected from the apical side to central lumen. The BDC were found to incorporate [14C]oleic acid (in nmol/mg protein) into triglycerides (121 +/- 6), phospholipids (PL; 59 +/- 3), and cholesteryl ester (16 +/- 1). The medium lipid content represented 5.90 +/- 0.16% (P < 0. 005) of the total intracellular production, indicating a limited lipid export capacity. Analysis of PL composition demonstrated the synthesis of all classes of polar lipids, with phosphatidylcholine and phosphatidylethanolamine accounting for 60 +/- 1 and 24 +/- 1%, respectively, of the total. Differences in PL distribution were apparent between cells and media. Substantial cholesterol synthesis was observed in BDC, as determined by the incorporation of [14C]acetate suggesting the presence of hydroxymethylglutaryl CoA (HMG-CoA) reductase, the rate-limiting enzyme in the cholesterol biosynthetic pathway. With the use of [14C]acetate and [14C]cholesterol as precursors, both tauro- and glycoconjugates of bile acids were synthesized, indicating the presence of cholesterol 7alpha- and 26R-hydroxylases, the key enzymes involved in bile acid formation. The transport of bile acids was not limited, as shown by their marked accumulation in the medium (>6-fold of cell content). HMG-CoA reductase (53.0 +/- 6.7), cholesterol 7alpha-hydroxylase (15. 5 +/- 0.5), and acyl-CoA:cholesterol acyltransferase (ACAT; 201.7 +/- 10.2) activities (in pmol. min-1. mg protein-1) were present in the microsomal fractions. Our data show that biliary epithelial cells actively synthesize lipids and may directly contribute bile acids to the biliary fluid in vivo. This BDC line thus represents an efficient experimental tool to evaluate biliary epithelium sterol metabolism and to study biliary physiology. PMID- 9950815 TI - Gastrin induces c-fos gene transcription via multiple signaling pathways. AB - We previously observed that the trophic actions of gastrin (G17) on the AR42J rat acinar cell line are mediated by mitogen-activated protein kinase (MAPK)-induced c-fos gene transcription via protein kinase C (PKC)-dependent and -independent pathways. In this study, we further investigated the signaling pathways that target c-fos in response to G17. G17 led to a sixfold induction in luciferase activity in cells transfected with plasmids containing the -356+109 sequence of the murine c-fos promoter, which includes the Sis-inducible element (SIE), serum response element (SRE), and the Ca2+/cAMP response element (CRE) regulatory elements. Addition of either the selective PKC inhibitor GF-109203X or the MAPK/extracellular signal-regulated kinase inhibitor PD-98059 resulted in an 80% reduction in luciferase activity. G17 induced the transcriptional activity of both Elk-1 and Sap-1a, transcription factors that bind to the E26 transformation specific (Ets) DNA sequence of the SRE, and this effect was inhibited by both GF 109203X and PD-98059. Point mutations in the Ets sequence led to a 4-fold induction of c-fos transcription stimulated by G17 and to a 1.3-fold induction in response to epidermal growth factor (EGF). In contrast, mutations in the CA rich G (CArG) sequence of the SRE prevented transcriptional activation by both G17 and EGF. G17 induction of the Ets mutant construct was unaffected by either GF 109203X or PD-98059. Because activation of the SRE involves the small GTP-binding protein Rho A, we examined the role of Rho A in G17 induction of c-fos transcription. Inactivation of Rho A by either the specific inhibitor C3 or by expression of a dominant negative Rho A gene inhibited G17 induction of both the wild-type and the Ets mutant constructs by 60%. C3 also inhibited G17-stimulated AR42J cell proliferation. Thus G17 targets the c-fos promoter CArG sequence via Rho A-dependent pathways, and Rho A appears to play an important role in the regulation of the trophic action of G17. PMID- 9950816 TI - Differentiation of mouth versus gut as site of origin of odoriferous breath gases after garlic ingestion. AB - Utilizing the sulfur-containing gases of garlic as probes, we investigated the gut versus mouth origin of odoriferous breath gases. Five individuals ingested 6 g of garlic, and sulfur gases in mouth, alveolar air, and urine samples were measured. The mouth normally contained low concentrations of hydrogen sulfide, methanethiol, and dimethyl sulfide. Immediately after garlic ingestion, transient high concentrations of methanethiol and allyl mercaptan and lesser concentrations of allyl methyl sulfide (AMS), allyl methyl disulfide, and allyl disulfide were observed. With the exception of AMS, all gases were present in far greater concentrations in mouth than alveolar air, indicating an oral origin. Only AMS was of gut origin as evidenced by similar partial pressures in mouth, alveolar air, and urine. After 3 h, AMS was the predominant breath sulfur gas. The unique derivation of AMS from the gut is attributable to the lack of gut and liver metabolism of this gas versus the rapid metabolism of the other gases. Breath odor after garlic ingestion initially originates from the mouth and subsequently from the gut. PMID- 9950817 TI - Kinetic analysis of 59Fe movement across the intestinal wall in duodenal rat segments ex vivo. AB - Duodenal segments from iron-deficient and iron-adequate rats were luminally perfused ex vivo with solutions containing 1, 10, 50, 100, 200 and 500 micromol 59Fe/l. When duodenal tissue load and mucosal-to-serosal transport had reached a steady state, perfusion was continued without luminal 59Fe supply. Mobilization of 59Fe from the duodenal tissue into the serosally released absorbate followed first-order rate kinetics, which permitted calculation of the asymptotic maximum, the rate constant, and the initial mobilization rate for tissue-to-absorbate transfer. There was no evidence for adaptation of 59Fe tissue binding in iron deficient segments. 59Fe tissue-to-absorbate transfer increased in proportion to the mobilizable fraction of recently absorbed iron in the tissue, which is indicative of simple diffusion or carrier-mediated transport below saturation. Regulation of the mucosal uptake step appears to determine the mobilizable 59Fe fraction and thus the adaptation of the overall iron absorption process to the demand. Iron retention in the duodenal tissue and iron transfer from here into the body appear not to be either regulated or rate limited. PMID- 9950819 TI - Activation of neuronal adenosine A1 receptors suppresses secretory reflexes in the guinea pig colon. AB - The role of adenosine A1 receptors (A1R) in reflex-evoked short-circuit current (Isc) indicative of chloride secretion was studied in the guinea pig colon. The A1R antagonist 8-cyclopentyltheophylline (CPT) enhanced reflex-evoked Isc. Adenosine deaminase and the nucleoside transport inhibitor S-(4-nitrobenzyl)-6 thioinosine enhanced and reduced reflex-induced Isc, respectively. The A1R agonist 2-chloro-N6-cyclopentyladenosine (CCPA) inhibited reflex-evoked Isc at nanomolar concentrations, and its action was antagonized by CPT. In the presence of either N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide to block the 5 hydroxytryptamine (5-HT)-mediated pathway or piroxicam to block the prostaglandin mediated pathway, CCPA reduced the residual reflex-evoked Isc. CCPA reduced the response to a 5-HT pulse without affecting the tetrodotoxin-insensitive Isc responses to carbachol or forskolin. Immunoreactivity for A1R was detected in the membrane (10% of neurons) and cytoplasm (90% of neurons) of neural protein gene product 9.5-immunoreactive (or S-100-negative) submucosal neurons, in glia, and in the muscularis mucosa. A1R immunoreactivity in a majority of neurons remained elevated in the cytoplasm despite preincubation with adenosine deaminase or CPT. A1R immunoreactivity colocalized in synaptophysin-immunoreactive presynaptic varicose nerve terminals. The results indicate that endogenous adenosine binding to high-affinity A1R on submucosal neurons acts as a physiological brake to suppress reflex-evoked Isc indicative of chloride secretion. PMID- 9950818 TI - Polyamine depletion is associated with an increase in JunD/AP-1 activity in small intestinal crypt cells. AB - Activator protein 1 (AP-1) is a group of dimeric transcription factors composed of protooncogene (Jun and Fos) subunits that bind to a common DNA site, the AP-1 binding site. The proteins of c-Jun, JunB, and Fos are essential for initiation of the cell cycle. Conversely, the activation of the junD gene slows cell growth in some cell types. The current study tests the hypothesis that polyamines influence cell growth by altering the balance of positive and negative Jun/AP-1 activities in intestinal epithelial cells. Studies were conducted in the IEC-6 cell line derived from rat small intestinal crypt cells. Administration of alpha difluoromethylornithine (DFMO), a specific inhibitor for polyamine synthesis, for 4 and 6 days completely depleted cellular polyamine levels, while AP-1 binding activity was significantly increased. Spermidine, when given together with DFMO, restored AP-1 binding activity toward normal. The increased AP-1 complexes in polyamine-deficient cells were dramatically supershifted by the anti-JunD antibody but not by antibodies against c-Jun, JunB, or Fos proteins. There were significant increases in JunD mRNA and protein in DFMO-treated cells, although expression of the c-fos, c-jun, and junB genes decreased. The increase in JunD/AP 1 activity in DFMO-treated cells was associated with a significant decrease in cell division. Exposure of control quiescent cells to 5% dialyzed serum increased c-Jun/AP-1 but not JunD/AP-1 activities. DFMO prevented the stimulation of c Jun/AP-1 activity induced by 5% dialyzed serum. These results indicate that 1) polyamine depletion is associated with an increase in AP-1 binding activity and 2) the increase in AP-1 activity in the DFMO-treated cells was primarily contributed by an increase in the JunD/AP-1. These findings suggest that polyamines regulate cell growth at least partially by modulating the balance of positive and negative Jun/AP-1 activities in the intestinal mucosa. PMID- 9950820 TI - Role of actin in EGF-induced alterations in enterocyte SGLT1 expression. AB - Na+-glucose cotransporter (SGLT1) expression and the role of actin in epidermal growth factor (EGF)-induced alterations in glucose transport and brush-border surface area were examined in New Zealand White rabbit jejunal loops. In separate experiments, EGF or EGF concurrent with cytochalasin D, an inhibitor of actin polymerization, was administered to the experimental loop and compared with its vehicle control. SGLT1 expression was measured by Western blot in brush-border membrane vesicles (BBMV) after 5-min and 1-h exposure. Glucose kinetics were determined by a rapid filtration technique, and brush-border surface area was examined by electron microscopy after 1-h exposure. The effect of cytochalasin D alone on BBMV glucose kinetics and brush-border surface area was also assessed. EGF resulted in a significant increase in BBMV SGLT1 expression (P < 0.05), glucose maximal uptake (Vmax; P < 0.001), and absorptive brush-border surface area (P < 0.001). These effects were abolished with concurrent cytochalasin D treatment. Cytochalasin D alone had no effect on glucose transport or brush border surface area. The findings suggest that EGF acutely upregulates jejunal brush-border surface area and the Vmax for jejunal glucose uptake via the recruitment and insertion of SGLT1 from an internal pool into the brush border by a mechanism that is dependent on actin polymerization. PMID- 9950821 TI - Expression of multiple Na+/H+ exchanger isoforms in rat parotid acinar and ductal cells. AB - Several members of the Na+/H+ exchanger gene family (NHE1, NHE2, NHE3, and NHE4) with unique functional properties have been cloned from rat epithelial tissues. The present study examined the molecular and pharmacological properties of Na+/H+ exchange in rat parotid salivary gland cells. In acinar cells superfused with a physiological salt solution (145 mM Na+), Na+/H+ exchanger activity was inhibited by low concentrations of the amiloride derivative ethylisopropyl amiloride (EIPA; IC50 = 0.014 +/- 0.005 microM), suggesting the expression of amiloride-sensitive isoforms NHE1 and/or NHE2. Semiquantitative RT-PCR confirmed that NHE1 transcripts are most abundant in this cell type. In contrast, the intermediate sensitivity of ductal cells to EIPA indicated that inhibitor-sensitive and resistant Na+/H+ exchanger isoforms are coexpressed. Ductal cells were about one order of magnitude more resistant to EIPA (IC50 = 0.754 +/- 0.104 microM) than cell lines expressing NHE1 or NHE2 (IC50 = 0.076 +/- 0.013 or 0.055 +/- 0.015 microM, respectively). Conversely, ductal cells were nearly one order of magnitude more sensitive to EIPA than a cell line expressing the NHE3 isoform (IC50 = 6.25 +/- 1.89 microM). Semiquantitative RT-PCR demonstrated that both NHE1 and NHE3 transcripts are expressed in ducts. NHE1 was immunolocalized to the basolateral membranes of acinar and ductal cells, whereas NHE3 was exclusively seen in the apical membrane of ductal cells. Immunoblotting, immunolocalization, and semiquantitative RT-PCR experiments failed to detect NHE2 expression in either cell type. Taken together, our results demonstrate that NHE1 is the dominant functional Na+/H+ exchanger in the plasma membrane of rat parotid acinar cells, whereas NHE1 and NHE3 act in concert to regulate the intracellular pH of ductal cells. PMID- 9950822 TI - Role of endotoxin in intestinal reperfusion-induced expression of E-selectin. AB - Products of enteric bacteria, including endotoxin [lipopolysaccharide (LPS)], have been implicated in the acute inflammatory responses elicited by ischemia and reperfusion (I/R) of the small intestine. The objective of this study was to assess the contribution of LPS to the increased E-selectin expression observed in the intestinal vasculature after I/R. The dual radiolabeled monoclonal antibody technique was used in LPS-sensitive (C3HeB/FeJ) and LPS-insensitive (C3H/HeJ) mice that were exposed to either exogenous LPS or to gut I/R (45 min ischemia, 5 h reperfusion). LPS elicited a dose-dependent (0.5-50 microgram LPS/animal) increase in E-selectin expression (at 3 h) in LPS-sensitive mice, whereas LPS insensitive mice were largely unresponsive. E-selectin expression was increased fivefold by I/R in the small bowel of both LPS-sensitive and -insensitive mice. These results indicate that, although exogenous LPS is capable of eliciting profound dose-dependent increases in E-selectin expression, endogenous LPS does not contribute significantly to I/R-induced expression of this endothelial cell adhesion molecule. PMID- 9950823 TI - Participation of reactive oxygen metabolites in Clostridium difficile toxin A induced enteritis in rats. AB - Reactive oxygen metabolites (ROMs) contribute to the pathophysiology of intestinal inflammation. Our aim was to ascertain the involvement of ROMs in experimental ileitis in rats produced by toxin A of Clostridium difficile. Intraluminal toxin A caused a significant increase in hydroxyl radical and hydrogen peroxide production by ileal microsomes starting 1 h following toxin exposure and peaking at 2-3 h, and this was inhibited by pretreatment with DMSO, a ROM scavenger, or superoxide dismutase (SOD), which inactivates ROMs. In contrast, mucosal xanthine oxidase increased only slightly after toxin A exposure, and allopurinol, an inhibitor of xanthine oxidase, had no effect on toxin A-associated intestinal responses. Induction of neutropenia resulted in reduction of toxin-mediated free radical formation, fluid secretion, and permeability. The enterotoxic effects of C. difficile toxin A were associated with increased ROM release in ileal tissues, and the ROM inhibitors DMSO and SOD inhibited these effects. This suggests that ROMs released during toxin A enteritis are released primarily from neutrophils invading the inflamed bowel segment. PMID- 9950824 TI - Electrogenic Na+ transport in rat late distal colon by natural and synthetic glucocorticosteroids. AB - The potency of in vitro-added corticosteroids to stimulate electrogenic Na+ absorption (JNa, the Na+ absorptive short-circuit current blockable by 10(-4) M amiloride) was determined in rat late distal colon. JNa was determined 8 h after steroid addition from the drop in short-circuit current caused by 10(-4) M amiloride. The concentration dependency of JNa was obtained for seven corticosteroids and compared with that established for aldosterone. Apparent mineralocorticoid potencies as determined from apparent Michaelis-Menten constant (Km) values were as follows: aldosterone 1. 2 nM >> RU-28362 20 nM = deoxycorticosterone 20 nM > deoxycortisol 36 nM >/= dexamethasone 37 nM >> corticosterone 170 nM > cortisol 210 nM. These steroids exhibited Vmax values of 9-13 micromol. h-1. cm-2 and similar concentration dependencies. Hill coefficients were between 1.6 and 2.1, suggesting cooperative effects between activated receptors. We conclude that corticosteroids exhibit graded mineralocorticoid potency instead of a sharp partition into exclusive groups of mineralocorticoid and nonmineralocorticoid hormones. The low apparent Km value of RU-28362 for mineralocorticoid action and the need for high concentrations of the mineralocorticoid antagonist mespirenone to block this response indicated that JNa in a native mammalian epithelium can be mediated by the glucocorticoid receptor. Glucocorticoid receptor-specific amounts of RU-28362 in combination with mineralocorticoid receptor-specific amounts of aldosterone or of the mineralocorticoid antagonist spironolactone showed cooperative action, suggesting a heterodimeric activation of JNa by the glucocorticoid receptor and mineralocorticoid receptor. PMID- 9950825 TI - Adenovirus-mediated gene transfer of RasN17 inhibits specific CCK actions on pancreatic acinar cells. AB - CCK stimulates pleiotrophic responses in pancreatic acinar cells; however, the intracellular signaling pathways involved are not well understood. To evaluate the role of the ras gene product in CCK actions, a strategy involving in vitro adenoviral-mediated gene delivery of a dominant-negative mutant Ras (RasN17) was utilized. Isolated acini were infected with various titers of either a control adenovirus or an adenoviral construct expressing RasN17 for 24 h before being treated with CCK. Titer-dependent expression of RasN17 in the acini was confirmed by Western blotting. Infection with control adenovirus [10(6)-10(9) plaque forming units/mg acinar protein (multiplicity of infection of approximately 1 1,000)] had no effect on CCK stimulation of acinar cell amylase release, extracellular-regulated kinase (ERK) or c-Jun kinase (JNK) kinases, or DNA synthesis. In contrast, infection with adenovirus bearing rasN17 increased basal amylase release, inhibited CCK-mediated JNK activation, had no effect on CCK activation of ERK, and inhibited DNA synthesis. These data demonstrate important roles for Ras in specific actions of CCK on pancreatic acinar function. PMID- 9950826 TI - Mechanisms of basolateral Na+ transport in rabbit esophageal epithelial cells. AB - We examined the mechanisms of cellular Na+ transport, both Cl- dependent and Cl- independent, in the mammalian esophageal epithelium. Rabbit esophageal epithelium was dissected from its muscular layers and mounted in a modified Ussing chamber for impalement with ion-selective microelectrodes. In bicarbonate Ringer, transepithelial potential difference was -14.9 +/- 0.9 mV, the transepithelial resistance (RTE) was 1,879 +/- 142 Omega. cm2, the basolateral membrane potential difference (VmBL) was -53 +/- 1.5 mV, and the intracellular activity of Na+ (aNai) was 24.6 +/- 2.1 mM. Removal of Na+ and Cl- from the serosal and luminal baths decreased aNai to 6.6 +/- 0.6 mM. Readdition of Na+ to the serosal bath in the absence of Cl- increased aNai by 21.8 +/- 3.0 mM, whereas VmBL and RTE remained unchanged. When serosal Na+ was readded in the presence of amiloride the increase in aNai and the rate of Na+ entry were decreased by approximately 50%. 5 (N-ethyl-N-isopropyl)amiloride mimicked the effect of amiloride, whereas phenamil did not. Subsequent readdition of Cl- to the serosal bath further increased aNai by 4.4 +/- 1.9 mM. When the cells were acid loaded by pretreatment with NH+4 in nominally HCO-3-free Ringer, intracellular pH measurements showed a pHi recovery that is dependent on the presence of Na+ in the serosal bath and that can be blocked by amiloride. These data indicate that esophageal epithelial cells possess a Na+-dependent, amiloride-sensitive electroneutral mechanism for Na+ entry consistent with the presence of a basolateral Na+/H+ exchanger. The ability of Cl- to further enhance Na+ entry supports the existence of at least one additional Cl--dependent component of basolateral Na+ entry. PMID- 9950827 TI - Voltage sensitivity of slow wave frequency in isolated circular muscle strips from guinea pig gastric antrum. AB - In circular muscle preparations isolated from the guinea pig gastric antrum, regular spontaneous electrical activity (slow waves) was recorded. Under normal conditions (6 mM K+), the frequency and shape of the slow waves were similar to those observed in ordinary stomach smooth muscle preparations. When the resting membrane potential was hyperpolarized and depolarized by changing the extracellular K+ concentration (2-18 mM), the frequency of slow waves decreased and increased, respectively. Application of cromakalim hyperpolarized the cell membrane and reduced the frequency of slow waves in a dose-dependent manner. Cromakalim (3 microM) hyperpolarized the membrane, and slow waves ceased in most preparations. In the presence of cromakalim, subsequent increases in the extracellular K+ concentration restored the frequency of slow waves accompanied by depolarization. Also, glibenclamide completely antagonized this effect of cromakalim. In smooth muscle strips containing both circular and longitudinal muscle layers, such changes in the slow wave frequency were not observed. It was concluded that the maneuver of isolating circular smooth muscle altered the voltage dependence of the slow wave frequency. PMID- 9950828 TI - Analysis of fast synaptic pathways in myenteric plexus of guinea pig ileum. AB - Most fast excitatory postsynaptic potentials (fEPSPs) recorded from guinea pig ileum myenteric plexus are mediated by acetylcholine acting at nicotinic receptors and ATP acting at P2X receptors. These studies examine length and polarity of projection of neurons releasing mediators of fEPSPs. Under ketamine xylazine anesthesia, animals were sham treated or myenteric pathways were interrupted. After severed axons degenerated, fEPSPs were recorded at the operated site using conventional, intracellular electrophysiological methods and were classified as nicotinic or mixed on the basis of sensitivity to hexamethonium. Cholinergic and noncholinergic fEPSPs were recorded from small, operated segments, suggesting that some neurons have projections between adjacent ganglia. The mean amplitudes of nicotinic and mixed fEPSPs were reduced after circumferential and descending pathways degenerated. The proportion of nicotinic vs. mixed fEPSPs recorded from tissues lacking descending projections was greater than that recorded from sham-treated tissues, suggesting that fibers releasing noncholinergic mediators project aborally. Descending projections communicate with neurons in ganglia at least three rows aboral to their origin. The data suggest that fast noncholinergic neurotransmission could contribute to hexamethonium-resistant descending inhibition during the peristaltic reflex. PMID- 9950829 TI - Differential regulation of NHE isoforms by sodium depletion in proximal and distal segments of rat colon. AB - Dietary sodium depletion has multiple diverse effects on ion transport in the rat colon, including both the induction and inhibition of electroneutral NaCl absorption in proximal and distal colon of rat, respectively. To establish the mechanism of the differential regulation of Na+ absorption by sodium depletion, this study utilized 1) HOE-694, a dose-dependent inhibitor of Na+/H+ exchanger (NHE) isoforms, in studies of proton gradient-driven 22Na uptake (i.e., Na+/H+ exchange) by apical membrane vesicles (AMV); 2) Northern blot analyses of NHE isoform-specific mRNA abundance; and 3) Western blot analyses of NHE isoform specific protein expression. HOE-694 inhibition studies establish that 25 microM HOE-694-sensitive (NHE2) and 25 microM HOE-694-insensitive (NHE3) Na+/H+ exchange activities are present in AMV of both proximal and distal colon of normal rats. In proximal colon, dietary sodium depletion enhanced both NHE2 and NHE3 isoform specific Na+/H+ exchange activities, protein expression, and mRNA abundance. In contrast, in distal colon both NHE2 and NHE3 isoform-specific Na+/H+ exchange activities, protein expression, and mRNA abundance were inhibited by sodium depletion. NHE1 isoform-specific mRNA abundance in proximal or distal colon was not altered by sodium depletion. Differential effects by sodium depletion on Na+/H+ exchange in rat colon are tissue specific and isoform specific; sodium depletion both induces and inhibits apical Na+/H+ exchange at a pretranslational level. PMID- 9950830 TI - Intestinal fat-induced inhibition of meal-stimulated gastric acid secretion depends on CCK but not peptide YY. AB - Fat in small intestine decreases meal-stimulated gastric acid secretion and slows gastric emptying. CCK is a mediator of this inhibitory effect (an enterogastrone). Because intravenously administered peptide YY (PYY) inhibits acid secretion, endogenous PYY released by fat may also be an enterogastrone. Four dogs were equipped with gastric, duodenal, and midgut fistulas. PYY antibody (anti-PYY) at a dose of 0.5 mg/kg or CCK-A receptor antagonist (devazepide) at a dose of 0.1 mg/kg was administered alone or in combination 10 min before the proximal half of the gut was perfused with 60 mM oleate or buffer. Acid secretion and gastric emptying were measured. We found that 1) peptone-induced gastric acid secretion was inhibited by intestinal fat (P < 0.0001), 2) inhibition of acid secretion by intestinal fat was reversed by CCK-A receptor antagonist (P < 0.0001) but not by anti-PYY, and 3) slowing of gastric emptying by fat was reversed by CCK-A antagonist (P < 0. 05) but not by anti-PYY. We concluded that inhibition of peptone meal-induced gastric acid secretion and slowing of gastric emptying by intestinal fat depended on CCK but not on circulating PYY. PMID- 9950831 TI - Characterization of the mechanisms involved in the gender differences in hepatic taurocholate uptake. AB - Gender differences in the hepatic transport of organic anions is well established. Although uptake of many organic anions is greater in females, sodium dependent taurocholate uptake is greater in hepatocytes from male rats. We examined the hypothesis that endogenous estrogens alter the number of sinusoidal bile acid transporters and/or decrease membrane lipid fluidity. The initial sodium-dependent uptake of [3H]taurocholate was 75% greater in hepatocytes from males than from either intact or oophorectomized females rats. Taurocholate maximal uptake was increased twofold (P < 0.03) without a significant change in the Michaelis-Menten constant. Sinusoidal membrane fractions were isolated from male and female rat livers with equal specific activities and enrichments of Na+ K+-ATPase. Males had a significant (P < 0.05) increase in cholesterol esters and phosphatidylethanolamine-to-phosphatidylcholine ratio. Fluorescence polarization indicated decreased lipid fluidity in females. In females, expression of the sodium-dependent taurocholate peptide (Ntcp) and mRNA were selectively decreased to 46 +/- 9 and 54 +/- 4% (P < 0.01), respectively, and the organic anion transporter peptide (Oatp) and Na+-K+-ATPase alpha-subunit were not significantly different. Nuclear run-on analysis indicated a 47% (P < 0.05) decrease in Ntcp transcription, without a significant change in Oatp. In conclusion, these studies demonstrated that decreased sodium-dependent bile salt uptake in female hepatocytes was due to decreased membrane lipid fluidity and a selective decrease in Ntcp. PMID- 9950832 TI - Adenosine A1 receptor-mediated antiadrenergic effects are modulated by A2a receptor activation in rat heart. AB - Presently, the physiological significance of myocardial adenosine A2a receptor stimulation is unclear. In this study, the influence of adenosine A2a receptor activation on A1 receptor-mediated antiadrenergic actions was studied using constant-flow perfused rat hearts and isolated rat ventricular myocytes. In isolated perfused hearts, the selective A2a receptor antagonists 8-(3 chlorostyryl)caffeine (CSC) and 4-(2-[7-amino-2-(2-furyl)[1,2, 4]triazolo[2,3 a][1,3,5]triazin-5-ylamino]ethyl)phenol (ZM-241385) potentiated adenosine mediated decreases in isoproterenol (Iso; 10(-8) M)-elicited contractile responses (+dP/dtmax) in a dose-dependent manner. The effect of ZM-241385 on adenosine-induced antiadrenergic actions was abolished by the selective A1 receptor antagonist 1,3-dipropyl-8-cyclopentylxanthine (10(-7) M), but not the selective A3 receptor antagonist 3-ethyl-5-benzyl-2-methyl-4-phenylethynyl-6 phenyl-1, 4-(+/-)-dihydropyridine-3,5-dicarboxylate (MRS-1191, 10(-7) M). The A2a receptor agonist carboxyethylphenethyl-aminoethyl-carboxyamido-adenosine (CGS 21680) at 10(-5) M attenuated the antiadrenergic effect of the selective A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA), whereas CSC did not influence the antiadrenergic action of this agonist. In isolated ventricular myocytes, CSC potentiated the inhibitory action of adenosine on Iso (2 x 10(-7) M)-elicited increases in intracellular Ca2+ concentration ([Ca2+]i) transients but did not influence Iso-induced changes in [Ca2+]i transients in the absence of exogenous adenosine. These results indicate that adenosine A2a receptor antagonists enhance A1-receptor-induced antiadrenergic responses and that A2a receptor agonists attenuate (albeit to a modest degree) the antiadrenergic actions of A1 receptor activation. In conclusion, the data in this study support the notion that an important physiological role of A2a receptors in the normal mammalian myocardium is to reduce A1 receptor-mediated antiadrenergic actions. PMID- 9950834 TI - Vasoconstrictor effect of endothelin-1 in human skin: role of ETA and ETB receptors. AB - The aim of this project was to investigate the role of ETA and ETB receptors in the mediation of endothelin (ET)-1-induced vasoconstriction in human skin. This information should provide important insights into the design of pharmacological intervention against skin vasospasm induced by ET-1 in peripheral vascular disease or surgical trauma. Vasoconstriction in response to intra-arterial drug infusion in isolated perfused human skin flaps (8 x 18 cm) derived from dermolipectomy specimens was assessed by studying changes in skin perfusion and perfusion pressure under constant flow rate in each drug treatment (n = 4). It was observed that ET-1 (10(-10) to 10(-8) M) and norepinephrine (NE, 10(-8) to 10(-5) M) caused skin vasoconstriction in a concentration-dependent manner, with the vasoconstrictor potency of ET-1 approximately 200-fold higher than NE. The ETA-receptor antagonist BQ-123 but not the ETB-receptor antagonist BQ-788 blocked the vasoconstrictor effect of ET-1. This observation was confirmed by studying skin perfusion using the dermofluorometry technique. In addition, ETB-receptor agonists BQ-3020 and sarafotoxin S6c (10(-9) to 10(-6) M) did not evoke skin vasoconstriction. BQ-3020 also did not elicit skin vasoconstriction even in the presence of 10(-5) M of Nomega-nitro-L-arginine methyl ester and indomethacin. Furthermore, results from saturable and competitive ET-1 radioligand membrane receptor binding assays revealed that high-affinity and capacity binding sites are predominantly the ETA receptor subtype in endothelium-denuded skin arteries and veins of 0.5-1.5 mm diameter, with an ETA-to-ETB receptor ratio of 83:17 in arteries (n = 5) and 78:22 in veins (n = 7). Results from the present functional and radioligand receptor binding studies clearly indicate that ET-1 is a very potent vasoconstrictor in human skin and its vasoconstrictor effect is primarily mediated by ETA receptors, with no significant participation from ETB receptors. PMID- 9950833 TI - Hypertrophic response to hemodynamic overload: role of load vs. renin-angiotensin system activation. AB - Myocardial hypertrophy is one of the basic mechanisms by which the heart compensates for hemodynamic overload. The mechanisms by which hemodynamic overload is transduced by the cardiac muscle cell and translated into cardiac hypertrophy are not completely understood. Candidates include activation of the renin-angiotensin system (RAS) and angiotensin II receptor (AT1) stimulation. In this study, we tested the hypothesis that load, independent of the RAS, is sufficient to stimulate cardiac growth. Four groups of cats were studied: 14 normal controls, 20 pulmonary artery-banded (PAB) cats, 7 PAB cats in whom the AT1 was concomitantly and continuously blocked with losartan, and 8 PAB cats in whom the angiotensin-converting enzyme (ACE) was concomitantly and continuously blocked with captopril. Losartan cats had at least a one-log order increase in the ED50 of the blood pressure response to angiotensin II infusion. Right ventricular (RV) hypertrophy was assessed using the RV mass-to-body weight ratio and ventricular cardiocyte size. RV hemodynamic overload was assessed by measuring RV systolic and diastolic pressures. Neither the extent of RV pressure overload nor RV hypertrophy that resulted from PAB was affected by AT1 blockade with losartan or ACE inhibition with captopril. RV systolic pressure was increased from 21 +/- 3 mmHg in normals to 68 +/- 4 mmHg in PAB, 65 +/- 5 mmHg in PAB plus losartan and 62 +/- 3 mmHg in PAB plus captopril. RV-to-body weight ratio increased from 0.52 +/- 0.04 g/kg in normals to 1.11 +/- 0.06 g/kg in PAB, 1.06 +/- 0.06 g/kg in PAB plus losartan and 1.06 +/- 0.06 g/kg in PAB plus captopril. Thus 1) pharmacological modulation of the RAS with losartan and captopril did not change the extent of the hemodynamic overload or the hypertrophic response induced by PAB; 2) neither RAS activation nor angiotensin II receptor stimulation is an obligatory and necessary component of the signaling pathway that acts as an intermediary coupling load to the hypertrophic response; and 3) load, independent of the RAS, is capable of stimulating cardiac growth. PMID- 9950835 TI - An adenosine agonist and preconditioning shift the distribution of myocardial blood flow in conscious pigs. AB - The goal of this study was to determine whether the cardioprotective effects of an A1-receptor agonist and ischemic preconditioning (IPC) involve a shift in the pre-coronary artery occlusion (CAO) spatial distribution of myocardial blood flow, which might shed light on the mechanism of IPC and explain its heterogeneous effects. Accordingly, 60 min of CAO followed by 72 h of coronary artery reperfusion (CAR) was examined in three groups of conscious pigs 10-14 days after instrumentation with aortic and left atrial catheters and coronary artery occluders. Myocardial infarct size, expressed as a fraction of the area at risk (AAR), was reduced significantly (P < 0.05) by infusion of the A1 agonist (27.1 +/- 6.6%) and to a greater extent (P < 0.05) by IPC (11.6 +/- 5.1%) compared with infarct size in vehicle-treated animals (55.1 +/- 2.9%). Transmural myocardial blood flow (radioactive microspheres) in the AAR shifted toward lower levels after infusion of the A1 agonist (1.27 +/- 0.19 vs. 0.74 +/- 0.10 ml. min 1. g-1) or IPC (1.27 +/- 0.11 vs. 0.96 +/- 0.09 ml. min-1. g-1) but not after infusion of the vehicle (1.20 +/- 0.10 vs. 1.23 +/- 0.09 ml. min-1. g-1). This study demonstrated that both pretreatment with an adenosine A1 agonist and also IPC altered the spatial distribution of pre-CAO myocardial blood flow, which might reflect a downregulation of metabolic state and thus play a role in the cardioprotective effects of IPC. PMID- 9950836 TI - Metabolism of cAMP to adenosine: role in vasodilation of rat pial artery in response to hypotension. AB - The purpose of this experiment was to examine whether the cAMP-adenosine pathway is implicated in the autoregulatory vasodilation in response to hypotension. Suffusion with cAMP (1-100 micromol/l) or adenosine (0.01-10 micromol/l) caused a sustained vasodilation of the resting pial arteries in a concentration-dependent manner. In contrast, N6,2'-O-dibutyryl-cAMP and 8-bromo-cAMP exerted a weak dilation at high concentration (100 micromol/l). The vasodilation to cAMP (1-100 micromol/l), adenosine (0.01-10 micromol/l), and hypotension was significantly reduced by pretreatment with 3,7-dimethyl-1-propargylxanthine (1 micromol/l), an A2 receptor antagonist, as well as 3-isobutyl-1-methylxanthine (3 micromol/l), an inhibitor of endo- and ectophosphodiesterase, 1, 3-dipropyl-8-p sulfophenylxanthine (100 micromol/l), an inhibitor of ecto-5'-phosphodiesterase, or alpha,beta-methylene-adenosine 5'-diphosphate (100 micromol/l), an inhibitor of ecto-5'-nucleotidase. However, 8-cyclopentyltheophylline (1 micromol/l), an A1 antagonist, did not elicit a similar response. The increased release of adenosine when the cortical surface was suffused with cAMP (100 micromol/l) was significantly reduced by 3-isobutyl-1-methylxanthine, 1,3-dipropyl-8-p sulfophenylxanthine, and alpha,beta-methylene-adenosine 5'-diphosphate (each 100 micromol/l). These results indicate that the cAMP-adenosine pathway as a viable metabolic mechanism is implicated in the production of adenosine in the rat pial artery and contributes to the regulation of vasodilation in response to hypotension. PMID- 9950837 TI - Endothelium-independent vascular relaxation mediating ETB receptor in rabbit mesenteric arteries. AB - Vascular response mediating endothelin (ET)B receptor was studied using isolated rabbit mesenteric arteries. ET-1 (0.1-30 nM) caused a concentration-dependent contraction, whereas ET-3 >100 nM caused only weak contraction. Up to 1 microM of sarafotoxin S6c showed no contraction. In arteries precontracted with phenylephrine, ET-3 (0. 03-1 nM) caused a concentration-dependent relaxation, which was not affected by endothelium denudation. The ET-3-induced relaxation was antagonized by BQ-788 and PD-142893 but not by BQ-123 in the endothelium-denuded arteries. Treatment with indomethacin but not with NG-nitro-L-arginine methyl ester completely inhibited the relaxation. ET-3 stimulated the release of 6-keto PGF1alpha and PGE2 from the endothelium-denuded arteries. ET-3 also significantly increased cAMP content but not cGMP content in the arteries. Radioligand-binding studies using serial sections of the artery revealed the expression of not only ETA but also ETB receptors in the smooth muscle layer of the arteries. These results suggest that ET-3 activates ETB receptor in smooth muscle cells of rabbit mesenteric artery, producing vasodilator prostaglandins from arachidonic acid probably via a catalysis of cyclooxygenase, which accumulates cAMP in subendothelial tissues and produces relaxations. PMID- 9950838 TI - Electrical interactions among real cardiac cells and cell models in a linear strand. AB - Previous work with model systems for action potential conduction have been restricted to conduction between two real cells or conduction between a model cell and a real cell. The inclusion of additional elements to make a linear strand has allowed us to investigate the interactions between cells at a higher level of complexity. When, in the simplest case of a linear strand of three elements, the conductance between elements 2 and 3 (GC2) is varied, this affects the success or failure of propagation between elements 1 and 2 (coupled by GC1) as well as the success or failure of propagation between elements 2 and 3. Several major features were illustrated. 1) When GC1 was only slightly greater than the coupling conductance required for successful propagation between a model cell and a real cell, addition of a third element of the strand either prevented conduction from element 1 to element 2 (when GC2 was high) or allowed conduction from element 1 to element 2 but not conduction from element 2 to element 3 (when GC2 was low). 2) For higher levels of GC1, there was an allowable "window" of values of GC2 for successful conduction from element 1 through to element 3. The size of this allowable window of GC2 values increased with increasing values of GC1, and this increase was produced by increases in the upper bound of GC2 values. 3) When the size of the central element of the strand was reduced, this facilitated conduction through the strand, increasing the range of the allowable window of GC2 values. The overall success or failure of conduction through a structure of cells that has a spatially inhomogeneous distribution of coupling conductances cannot be predicted simply by the average or the minimum value of coupling conductance but may depend on the actual spatial distribution of these conductances. PMID- 9950839 TI - Rostral dorsolateral pontine neurons with sympathetic nerve-related activity. AB - Spike-triggered averaging, arterial pulse-triggered analysis, and coherence analysis were used to classify rostral dorsolateral pontine (RDLP) neurons into groups whose naturally occurring discharges were correlated to only the 10-Hz rhythm (n = 29), to only the cardiac-related rhythm (n = 15), and to both rhythms (n = 15) in inferior cardiac sympathetic nerve discharge (SND) of urethan anesthetized cats. Most of the neurons with activity correlated to only the cardiac-related rhythm were located medial to the other two groups of neurons. The firing rates of most RDLP neurons with activity correlated to only the 10-Hz rhythm (9 of 12) or both rhythms (7 of 8) were decreased during baroreceptor reflex-induced inhibition of SND produced by aortic obstruction; thus, they are presumed to be sympathoexcitatory. The firing rates of four of seven RDLP neurons with activity correlated to only the cardiac-related rhythm increased during baroreceptor reflex activation; thus, they may be sympathoinhibitory. We conclude that the RDLP contains a functionally heterogeneous population of neurons with sympathetic nerve-related activity. These neurons could not be antidromically activated by stimulation of the thoracic spinal cord. PMID- 9950840 TI - Dispersion-based reentry: mechanism of initiation of ventricular tachycardia in isolated rabbit hearts. AB - The aim of the study was to determine whether facilitation of reentry by potassium-channel openers is related to dispersion of refractoriness and/or modification of anisotropic properties of ventricular myocardium. The dispersion of ventricular effective refractory period (VERP), longitudinal and transverse ventricular conduction velocities (thetaL and thetaT, respectively), and wavelength [lambda = VERP x theta(L or T)] were studied in Langendorff-perfused left ventricular epicardium in 20 rabbits during infusion of incremental doses of levcromakalim or nicorandil. Dispersion of refractoriness was assessed using standard deviation of VERP mean (SD-VERP), dispersion index (DI; SD-VERP/mean VERP), and maximum dispersion (Dmax = VERPmax - VERPmin). Ventricular conduction velocities and anisotropic ratio were not modified, whatever the dose used. VERP and lambda were significantly shortened at high concentrations of levcromakalim and nicorandil. At these doses, SD-VERP, DI, and Dmax were increased significantly. Analysis of ventricular tachycardia induction, performed using a high-resolution ventricular mapping system, confirmed that heterogeneity and shortening of VERP were factors inducing functional conduction block. Our data suggest that, in rabbit left ventricular epicardium, functional conduction block facilitating the occurrence of reentry could be initiated by shortening and, especially, by dispersion of refractoriness during infusion of potassium-channel openers. PMID- 9950841 TI - Use of pulse pressure method for estimating total arterial compliance in vivo. AB - We determined total arterial compliance from pressure and flow in the ascending aorta of seven anesthetized dogs using the pulse pressure method (PPM) and the decay time method (DTM). Compliance was determined under control and during occlusion of the aorta at four different locations (iliac, renal, diaphragm, and proximal descending thoracic aorta). Compliance of PPM gave consistently lower values (0.893 +/- 0.015) compared with the compliance of DTM (means +/- SE; r = 0.989). The lower compliance estimates by the PPM can be attributed to the difference in mean pressures at which compliance is determined (mean pressure, 81.0 +/- 3.6 mmHg; mean diastolic pressure, over which the DTM applies, 67.0 +/- 3.6 mmHg). Total arterial compliance under control conditions was 0.169 +/- 0. 007 ml/mmHg. Compliance of the proximal aorta, obtained during occlusion of the proximal descending aorta, was 0.100 +/- 0.007 ml/mmHg. Mean aortic pressure was 80.4 +/- 3.6 mmHg during control and 102 +/- 7.7 mmHg during proximal descending aortic occlusion. From these results and assuming that upper limbs and the head contribute as little as the lower limbs, we conclude that 60% of total arterial compliance resides in the proximal aorta. When we take into account the inverse relationship between pressure and compliance, the contribution of the proximal aorta to the total arterial compliance is even more significant. PMID- 9950842 TI - Synchrotron microangiography reveals configurational changes and to-and-fro flow in intramyocardial vessels. AB - In 8 dogs, in situ microangiography using synchrotron radiation visualized penetrating transmural arteries (PTAs) with a diameter of >60 micrometers and allowed quantitation of vessel diameters of >140 micrometers. Myocardial contraction reduced the vascular short-axial diameters to 87 +/- 17% (n = 62, P < 0.001, paired t-test) of the end-diastolic values and increased the longitudinal dimension to 129 +/- 5% (n = 45, P < 0.001). The diameter reduction in the subendocardial PTA segments was significantly more marked than that in the subepicardial PTA segments (60 +/- 12 vs. 88 +/- 12%, n=13, P < 0.001, paired t test). Intracoronary administration of dobutamine (0.1 micrograms. kg-1. min-1) increased, and in contrast, partial clamping of the coronary artery (ischemia) decreased, the configurational changes. To-and-fro blood flow was clearly observed in PTAs with visual identification of capacitive backflow, resistive forward flow during ischemia on coronary arteriography, and even under baseline conditions in coronary venography. Thus this method advances our understanding of mechanical influences on the coronary circulation. PMID- 9950843 TI - Arterial O2 content and tension in regulation of cardiac output and leg blood flow during exercise in humans. AB - A universal O2 sensor presumes that compensation for impaired O2 delivery is triggered by low O2 tension, but in humans, comparisons of compensatory responses to altered arterial O2 content (CaO2) or tension (PaO2) have not been reported. To directly compare cardiac output (QTOT) and leg blood flow (LBF) responses to a range of CaO2 and PaO2, seven healthy young men were studied during two-legged knee extension exercise with control hemoglobin concentration ([Hb] = 144.4 +/- 4 g/l) and at least 1 wk later after isovolemic hemodilution ([Hb] = 115 +/- 2 g/l). On each study day, subjects exercised twice at 30 W and on to voluntary exhaustion with an FIO2 of 0.21 or 0.11. The interventions resulted in two conditions with matched CaO2 but markedly different PaO2 (hypoxia and anemia) and two conditions with matched PaO2 and different CaO2 (hypoxia and anemia + hypoxia). PaO2 varied from 46 +/- 3 Torr in hypoxia to 95 +/- 3 Torr (range 37 to >100) in anemia (P < 0.001), yet LBF at exercise was nearly identical. However, as CaO2 dropped from 190 +/- 5 ml/l in control to 132 +/- 2 ml/l in anemia + hypoxia (P < 0.001), QTOT and LBF at 30 W rose to 12.8 +/- 0.8 and 7.2 +/- 0.3 l/min, respectively, values 23 and 47% above control (P < 0.01). Thus regulation of QTOT, LBF, and arterial O2 delivery to contracting intact human skeletal muscle is dependent for signaling primarily on CaO2, not PaO2. This finding suggests that factors related to CaO2 or [Hb] may play an important role in the regulation of blood flow during exercise in humans. PMID- 9950844 TI - A canine model of chronic ischemic cardiomyopathy: characterization of regional flow-function relations. AB - The controversy regarding the mechanism(s) of left ventricular (LV) dysfunction in chronic coronary artery disease is, in part, related to the lack of an appropriate animal model for this condition. We have developed such a model by placing Ameroid constrictors on proximal portions of coronary arteries in dogs who were euthanized (mean of 6 wk) after the development of severe global LV dysfunction noted on two-dimensional echocardiography. The LV end-systolic size nearly doubled (P < 0.001) over the observation period, and the percent change in LV size from end diastole to end systole decreased by >50% (P < 0.001). Regional dysfunction was noted in 23 of 24 myocardial beds analyzed within regions showing no gross evidence of infarction. In 10 of these beds, severe dysfunction was noted without a decrease in radiolabeled microsphere-derived myocardial blood flow (MBF). In 13 myocardial beds, decrease in function was associated with a decrease in MBF (P < 0.001), with close coupling noted between percent wall thickening and MBF. In the beds that exhibited an ultimate decrease in MBF, the decrease in function preceded the decrease in MBF. In conclusion, we describe chronic LV dysfunction in a canine model of multivessel stenosis that closely mimics chronic ischemic LV dysfunction in humans. Whereas regional function is severely reduced in this model, MBF is varied in different segments and at different times during the observation period. These results provide new insights regarding flow-function relations in chronic ischemic LV dysfunction. PMID- 9950845 TI - Preserved hypocapnic pial arteriolar constriction during hyperammonemia by glutamine synthetase inhibition. AB - Ammonia intoxication, which results in astrocytic edema and glutamine accumulation, blocks cerebral vasodilation during hypercapnia but not during hypoxia. Ammonia's effect on blood flow during hypocapnia is unclear, with some brain regions showing a paradoxical increase in flow. Here, we studied the responses to hypocapnia of pial arterioles not surrounded by astrocytic end feet to avoid mechanical compression by local edema. Blood flow was measured by microspheres in pentobarbital sodium-anesthetized rats equipped with closed cranial windows that permitted intravital microscopy. The normal pial arterial constriction in hypocapnia (12 +/- 1%; mean +/- SE) was blocked (2 +/- 1%) during a 6-h intravenous infusion of ammonium acetate, with some regions (cerebrum, midbrain) showing increased flow during hypocapnia. After pretreatment with methionine sulfoximine (MSO), which inhibits glutamine synthesis, the normal hypocapnic constrictor response was retained in pial arterioles (11 +/- 2%) during hyperammonemia. The increase in the calculated cerebrovascular resistance also was retained. An analog of MSO that does not block glutamine synthesis (buthionine sulfoximine) was ineffective in maintaining hypocapnic reactivity. In a sodium acetate-treated control group, MSO did not alter the pial arteriolar response. Normal vasoconstrictive ability was shown during ammonium infusion in response to U-46619, a thromboxane analog. We conclude that the inhibition of hypocapnic responsivity induced by ammonium is not due to paralysis of the pial arteriolar smooth muscle or to vascular compression by swollen astrocytes but is in some way due to glutamine metabolically produced from the ammonium. PMID- 9950846 TI - Influence of chronic ethanol consumption on arterial tone in young and aged rats. AB - The aim of this work was to evaluate the effects of long-term ethanol consumption on arterial responses in vitro in young and aged rats. Therefore, Wistar rats (ages 3 and 29 mo, respectively) were allocated to six groups: control-young, sucrose-young, ethanol-young, control-aged, sucrose-aged, and ethanol-aged. The ethanol-fed groups were given 25% ethanol by intragastric gavage three times a day 4 days a week. Responses of mesenteric arterial rings were examined in standard organ chambers after 5 treatment weeks. In norepinephrine-precontracted arterial rings, endothelium-dependent relaxations to acetylcholine, as well as endothelium-independent relaxations to isoproterenol, were attenuated in aged rats when compared with young controls. Relaxation responses to isoproterenol, but not to acetylcholine and nitroprusside, were clearly improved by ethanol treatment in both young and aged rats. The cyclooxygenase inhibitor diclofenac, which reduces the synthesis of dilating and constricting prostanoids, enhanced the relaxation to acetylcholine in all three aged rat groups but was without significant effect in the young rats. In the presence of the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester the relaxation to acetylcholine in control and sucrose-fed aged rats was markedly reduced compared with control rats, whereas in the young controls and in both young and aged ethanol-exposed groups, distinct relaxations to higher concentrations of acetylcholine were still present. The endothelium-independent relaxations to cromakalim, a hyperpolarizing vasodilator acting via ATP-sensitive potassium channels, were also markedly augmented by ethanol feeding in both young and aged rats. In conclusion, ethanol consumption in both young and aged rats was associated with markedly improved arterial relaxations to isoproterenol and cromakalim, as well as clearly augmented relaxation to acetylcholine during inhibition of cyclooxygenase and nitric oxide synthase. These findings suggest that especially the potassium channel-related component of arterial relaxation was augmented by long-term ethanol exposure. PMID- 9950847 TI - Surgical procedure affects physiological parameters in rat myocardial ischemia: need for mechanical ventilation. AB - Several surgical approaches are being used to induce myocardial ischemia in rats. The present study investigated two different operative procedures in spontaneously breathing and mechanically ventilated rats under sham conditions. A snare around the left coronary artery (LCA) was achieved without occlusion. Left lateral thoracotomy was performed in spontaneously breathing and mechanically ventilated rats (tidal volume 8 ml/kg) with a respiratory rate of 90 strokes/min at different levels of O2 supplementation (room air and 30, 40, and 90% O2). All animals were observed for 60 min after thoracotomy. Rats operated with exteriorization of the heart through left lateral thoracotomy while breathing spontaneously developed severe hypoxia and hypercapnia despite an intrathoracic operation time of <1 min. Arterial O2 content decreased from 18.7 +/- 0.5 to 3.3 +/- 0.9 vol%. Lactate increased from 1.2 +/- 0.1 to 5.2 +/- 0.3 mmol/l. Significant signs of ischemia were seen in the electrocardiogram up to 60 min. Mechanically ventilated animals exhibited a spectrum ranging from hypoxia (room air) to hyperoxia (90% O2). In order not to jeopardize findings in experimental myocardial ischemia-reperfusion injury models, stable physiological parameters can be achieved in mechanically ventilated rats at an O2 application of 30-40% at 90 strokes/min. PMID- 9950848 TI - Possible obligatory functions of cyclic nucleotides in hypercapnia-induced cerebral vasodilation in adult rats. AB - Current evidence suggests that nitric oxide (NO) and vasodilating prostanoids, possibly via the actions of cGMP and cAMP, play permissive roles in hypercapnic cerebral vasodilation. The present study examined whether cGMP and cAMP have obligatory functions in hypercapnia. Using a closed cranial window in adult rats, we measured pial arteriolar diameters and periarachnoid cerebrospinal fluid (pCSF) cyclic nucleotide levels during normo- and hypercapnia and in the presence or absence of inhibitors of neuronal NO synthase (nNOS) or cyclooxygenase (COX). Also, we measured cGMP and cAMP contents in primary neuronal and astrocyte cultures, at different levels of CO2. Hypercapnia (arterial PCO2 65 mmHg)-induced pial arteriolar dilation was accompanied by 70-80% elevations in pCSF cGMP and cAMP. Inhibition of nNOS with 7-nitroindazole (7-NI) significantly reduced both the CO2-induced arteriolar dilation (by 77%) and the pCSF cGMP and cAMP increases (by 60-70%). Inhibition of COX with indomethacin reduced arteriolar CO2 reactivity (by 83%) and pCSF cyclic nucleotide increases (by 80-100%). In neuronal cultures a transient NO-dependent increase in cGMP, but not cAMP, was seen when the CO2 level was raised from 5 to 14%. No changes were seen in astrocytes. The 7-NI and indomethacin-inhibitable increases in pial arteriolar diameter and cyclic nucleotide production during hypercapnia suggest a link between these two responses. One possible, although not exclusive, interpretation of these findings is that the cyclic nucleotides have an obligatory function in the CO2 response. The large overlap in the abilities of nNOS and COX inhibitors to elicit those effects further implies interactions ("cross talk") between the cGMP and cAMP vasodilating pathways. The in vitro data suggest that hypercapnia stimulates NO production in neurons. PMID- 9950849 TI - Adenosine-induced activation of ATP-sensitive K+ channels in excised membrane patches is mediated by PKC. AB - Both protein kinase C (PKC) and adenosine receptor activation have been shown to enhance ATP-sensitive K+ (KATP) channels. The present studies were designed to determine whether PKC mediates adenosine effects on the KATP channel. The dependence of KATP channel activity (nPo) on intracellular ATP concentration ([ATP]i) was determined in excised rabbit ventricular membrane patches. External adenosine (100 microM in the pipette solution) significantly increased KATP nPo at all [ATP]i between 5 and 50 microM by decreasing channel sensitivity to [ATP]i (dissociation constant increased from 7.4 +/- 0.8 to 22.2 +/- 3.1 microM, P < 0.001), an effect blocked by the adenosine receptor antagonist 8 phenyltheophylline (10 microM). When the highly selective PKC blocker bisindolylmaleimide (BIM) was included in the internal (bath) solution, the KATP stimulating action of adenosine was prevented. The addition of BIM to the superfusate rapidly inhibited KATP channels activated by adenosine. Endogenous PKC activation by phorbol 12,13-didecanoate (PDD), but not administration of the inactive congener 4alpha-PDD, enhanced KATP activity. Internal guanosine 5'-O-(2 thiodiphosphate) prevented KATP activation by adenosine, an effect which could be overridden by exposure to PDD. We conclude that PKC mediates adenosine activation of KATP channels in excised membrane patches in a membrane-delimited fashion. PMID- 9950850 TI - Reversal of permeability transition during recovery of hearts from ischemia and its enhancement by pyruvate. AB - We have used mitochondrial entrapment of 2-deoxy-D-[3H]glucose (2-DG) to demonstrate that recovery of Langendorff-perfused rat hearts from ischemia is accompanied by reversal of the mitochondrial permeability transition (MPT). In hearts loaded with 2-DG before 40 min of ischemia and 25 min of reperfusion, 2-DG entrapment [expressed as 10(5) x (mitochondrial 2-[3H]DG dpm per unit citrate synthase)/(total heart 2-[3H]DG dpm/g wet wt)] increased from 11.1 +/- 1.3 (no ischemia, n = 4) to 32.5 +/- 1.9 (n = 6; P < 0.001). In other experiments, 2-DG was loaded after 25 min of reperfusion to determine whether some mitochondria that had undergone the MPT during the initial phase of reperfusion subsequently "resealed" and thus no longer took up 2-DG. The reduction of 2-DG entrapment to 20. 6 +/- 2.4 units (n = 5) confirmed that this was the case. Pyruvate (10 mM) in the perfusion medium increased recovery of left ventricular developed pressure from 57.2 +/- 10.3 to 98.9 +/- 10.8% (n = 6; P < 0.05) and reduced entrapment of 2-DG loaded preischemically and postischemically to 23.5 +/- 1.5 (n = 4; P < 0. 001) and 10.5 +/- 0.5 (n = 4; P < 0.01) units, respectively. The presence of pyruvate increased tissue lactate content at the end of ischemia and decreased the effluent pH during the initial phase of reperfusion concomitant with an increase in lactate output. We suggest that pyruvate may inhibit the MPT by decreasing pHi and scavenging free radicals, thus protecting hearts from reperfusion injury. PMID- 9950851 TI - Cytochrome P-450 omega-hydroxylase senses O2 in hamster muscle, but not cheek pouch epithelium, microcirculation. AB - The goal of this study was to investigate the role of cytochrome P-450 omega hydroxylase in mediating O2-induced constriction of arterioles in the microcirculation of the hamster. Male Golden hamsters were anesthetized with pentobarbital sodium, and the cremaster muscle or cheek pouch was prepared for observation by intravital microscopy. Arteriolar diameters were measured during elevations of superfusate PO2 from approximately 5 to 150 mmHg. Arteriolar responses to elevated PO2 were determined in the cremaster muscle, in the retractor muscle where it inserts on the cheek pouch, and in the epithelial portion of the cheek pouch. Elevation of superfusion solution PO2 caused a vigorous constriction of arterioles in the cremaster and retractor muscles and in the epithelial portion of the cheek pouch. Superfusion with 10 microM 17 octadecynoic acid, a suicide substrate inhibitor of cytochrome P-450 omega hydroxylase, and intravenous infusion of N-methylsulfonyl-12,12-dibromododec-11 enamide, a mechanistically different and highly selective inhibitor of cytochrome P-450 omega-hydroxylase, caused a significant reduction in the magnitude of O2 induced constriction of arterioles in the cremaster and retractor muscles. However, arteriolar constriction in response to elevated PO2 was unaffected by 17 octadecynoic acid or N-methylsulfonyl-12,12-dibromododec-11-enamide in the epithelial portion of the cheek pouch. These data confirm that there are regional differences in the mechanism of action of O2 on the microcirculation and indicate that cytochrome P-450 omega-hydroxylase senses O2 in the microcirculation of hamster skeletal muscle, but not in the cheek pouch epithelium. PMID- 9950852 TI - Electrical and mechanical responses of rat middle cerebral arteries to reduced PO2 and prostacyclin. AB - Isolated rat middle cerebral arteries were perfused and superfused with physiological salt solution equilibrated with a control (approximately 140 mmHg) or reduced (approximately 35-40 mmHg) PO2. In other experiments, cerebral arteries were isolated and prostacyclin release was determined by radioimmunoassay for 6-ketoprostaglandin F1alpha. Equilibration of the vessels with reduced PO2 (35 mmHg) solution caused a significant increase in prostacyclin release relative to control PO2 (140 mmHg) conditions. Exposure of middle cerebral arteries to reduced PO2 caused vascular smooth muscle (VSM) hyperpolarization and vessel relaxation, which could be blocked by 1 microM glibenclamide, an inhibitor of the ATP-sensitive K+ channel, but not by 1 mM tetraethylammonium (TEA), an inhibitor of the Ca2+-activated K+ channel. Glibenclamide also inhibited VSM hyperpolarization and vasodilation in response to the stable prostacyclin analog iloprost, but TEA did not affect iloprost induced dilation of the vessel. Endothelial removal eliminated the electrical and mechanical responses of the arteries to reduced PO2, but vessel responses to iloprost were similar to those of intact vessels. The results of this study are consistent with the hypothesis that hypoxic dilation of rat middle cerebral arteries is due to VSM hyperpolarization mediated by prostacyclin-induced activation of glibenclamide-sensitive K+ channels. PMID- 9950853 TI - In vivo effects of hydrostatic pressure on interstitium of abdominal wall muscle. AB - Fluid loss from the peritoneal cavity to surrounding tissue varies directly with intraperitoneal hydrostatic pressure (Pip). According to Darcy's law [Q = KA(dPif/dx)], fluid flux (Q) across a cross-sectional area (A) of tissue will increase with an increase in either hydraulic conductivity (K) or the interstitial fluid hydrostatic pressure gradient (dPif/dx, where x is distance). Previously, we demonstrated that in the anterior abdominal muscle (AAM) of rats, dPif/dx increases by only 40%, whereas K rises fivefold between Pip of 1.5 and 8 mmHg. Because K is a function of interstitial volume (thetaif), we hypothesized that perturbations of Pip would change Pif and expand the interstitium, increasing thetaif. To test this hypothesis, we used dual-label quantitative autoradiography (QAR) to measure extracellular fluid volume (thetaec) and intravascular volume (thetaiv) in the AAM of rats within the Pip range from -2.8 to +8 mmHg. thetaif was obtained by subtraction (thetaec - thetaiv). dPif/dx was measured with a micropipette and a servo-null system. Local thetaiv did not vary with Pip and averaged 0.010 +/- 0.002 ml/g, and thetaif averaged 0. 19 +/- 0.01 ml/g at Pif 0.001) in the SC. We conclude that the mechanisms responsible for the increase in K with Pip include expansion of the interstitium, dilution of interstitial macromolecules, and washout from the AAM to SC of interstitial macromolecules responsible for resistance to fluid flow. PMID- 9950854 TI - Human endothelial cells produce orosomucoid, an important component of the capillary barrier. AB - The serum protein orosomucoid (alpha1-acid glycoprotein) is needed to maintain the high capillary permselectivity required for normal homeostasis. It is not known how the protein executes its action, but it seems to contribute to the charge barrier. Moreover, recent studies suggest that the endothelial glycocalyx is essential for the charge barrier. The main site of orosomucoid synthesis is the liver, but we wanted to explore the possibility that orosomucoid was synthesized in endothelial cells. Primary cultures of human microvascular endothelial cells (HMVEC) from dermal tissue were established. Human liver cells were used as positive controls, and total RNA was prepared from both cell types. Reverse transcription-polymerase chain reaction (RT-PCR) was performed and demonstrated orosomucoid expression. After RT-PCR, the identities of the PCR products were confirmed by sequencing. RNase protection assay performed on total RNA from the HMVEC confirmed the results from the RT-PCR, i.e., orosomucoid mRNA is expressed by endothelial cells. Synthesis of orosomucoid in both liver and endothelial cells was demonstrated by immunoprecipitation. In conclusion, endothelial cells normally produce orosomucoid, which is essential for capillary charge selectivity. We suggest that orosomucoid exerts its effect by interacting with other components of the endothelial glycocalyx. PMID- 9950855 TI - Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability. AB - We previously demonstrated that vascular endothelial growth factor (VEGF) elicited increase in the permeability of coronary venules was blocked by the nitric oxide (NO) synthase inhibitor NG-monomethyl-L-arginine (L-NMMA). The aim of this study was to delineate in more detail the signaling pathways upstream from NO production in VEGF-induced venular hyperpermeability. The apparent permeability coefficient of albumin (Pa) and endothelial cytosolic Ca2+ concentration ([Ca2+]i) were measured in intact perfused porcine coronary venules using fluorescence microscopy. VEGF (10(-10) M) induced a two- to threefold increase in Pa, which was blocked by a monoclonal antibody directed against the VEGF receptor Flk-1/KDR, the phospholipase C (PLC) antagonist U-73122, or the protein kinase C (PKC) antagonist bisindolylmaleimide (BIM). In 12 venules that displayed the [Ca2+]i response to bradykinin (10(-6) M) and ionomycin (10(-6) M), only 4 vessels responded to VEGF with a transient increase in [Ca2+]i. Furthermore, Western blot analysis of cultured human umbilical vein endothelial cells showed that VEGF increased tyrosine phosphorylation of PLC-gamma and serine phosphorylation of endothelial constitutive NO synthase (ecNOS). The hyperphosphorylation of PLC-gamma was greatly attenuated by the KDR receptor antibody and U-73122, but not by BIM or L-NMMA. In contrast, U-73122 and BIM were able to inhibit VEGF-elicited serine phosphorylation of ecNOS. The results suggest that VEGF induces venular hyperpermeability through a KDR receptor mediated activation of PLC. In turn, ecNOS is activated by PLC-mediated PKC and/or cytosolic Ca2+ elevation stimulation. PMID- 9950856 TI - Early activation of transcription factor NF-kappaB during ischemia in perfused rat heart. AB - The transcription factor nuclear factor kappaB (NF-kappaB) regulates multiple immediate-early gene expressions involved in immune and inflammatory responses and cellular defenses. Ischemia-reperfusion induces many immediate-early gene expressions, but little is known about the NF-kappaB activation in myocardium during ischemia and reperfusion. This study demonstrated that ischemia alone rapidly induced NF-kappaB activation in the myocardium of isolated working rat hearts. Electrophoretic mobility shift assay showed that NF-kappaB binding activity significantly increased in the nucleus after 5 min of ischemia and remained elevated for up to 30 min. Western blot analysis suggested that the levels of inhibitory IkappaBalpha protein in the cytoplasm became markedly decreased at 4, 5, 7.5, and 10 min of ischemia but were gradually restored following 10 min of ischemia. Reduction of IkappaBalpha protein in the cytoplasm by ischemia resulted in NF-kappaB translocation to the nucleus. Northern blot hybridization showed that IkappaBalpha mRNA levels were not significantly elevated during myocardial ischemia. Pyrrolidine dithiocarbamate, an antioxidant, significantly inhibited the loss of IkappaBalpha protein from the cytoplasm and prevented NF-kappaB binding activity in the nucleus. Reperfusion following short periods of ischemia augmented NF-kappaB binding activity in the nucleus induced by ischemia. The results suggest that early activation of NF-kappaB induced by ischemia in the myocardium could be a signal mechanism for controlling and regulating immediate-early gene expression during ischemia-reperfusion. PMID- 9950857 TI - Microvascular responses to hemodilution with Hb vesicles as red blood cell substitutes: influence of O2 affinity. AB - Phospholipid vesicles encapsulating purified hemoglobin (HbV) were developed to provide O2-carrying capacity to plasma expanders. Microvascular perfusion was determined for HbV with different O2 affinity (P50 = 9, 16, and 30 mmHg) prepared by coencapsulating pyridoxal 5'-phosphate (PLP) at the molar ratios of [PLP]/[Hb] = 0, 0.5, and 3, respectively (cf. hamster blood, P50: 28 mmHg), and suspended in 8 g/dl human serum albumin (HSA). Eighty percent of the red blood cell (RBC) mass of conscious Syrian golden hamsters fitted with dorsal skinfold windows was substituted with either of the HbV-HSA suspensions, washed hamster RBC suspended in HSA (RBC-HSA), and HSA alone. All three HbV-HSA groups and RBC-HSA groups showed stable blood pressure and heart rate, which could not be sustained with HSA alone. Only the HbV (P50 = 9)-HSA group showed an increase in arterial O2 tension (89.8 +/- 14.7 mmHg, baseline 58.4 +/- 4.0 mmHg) because of hyperventilation, and microvascular perfusion was decreased, indicating that facilitated O2 unloading of HbV by decreasing the O2 affinity (increasing P50) with PLP as an allosteric effector is important. Microvascular perfusion and microvascular and interstitial O2 tensions in the HbV (P50 = 16 and 30)-HSA groups were significantly higher than those in the HSA group. The O2 release rate from the HbV was 18-32 s-1 vs. 4.4 s-1 for RBC. Functional capillary density was improved from 17 to 41% on average by decreasing P50 from 30 to 16 mmHg, which appears to be an optimal value for the P50 in this system. PMID- 9950858 TI - Changes in resistance vessels during hemorrhagic shock and resuscitation in conscious hamster model. AB - The unanesthetized hamster dorsal skinfold preparation was used to monitor diameters and blood flow rates in resistance arteries (small arteries, A0: diameter, 156 +/- 23 micrometers) and capacitance vessels (small veins, V0: 365 +/- 64 micrometers), during 45 min of hemorrhagic shock at 40 mmHg mean arterial pressure (MAP) and resuscitation. A0 and V0 vessels constricted significantly to 52 and 70% of the basal values, respectively, whereas precapillary arterioles (A1 A4, 8-60 micrometers) and collecting venules (VC-VL, 26-80 micrometers) did not change or tended to dilate. Blood flow rates in the microvessels declined to <20% of the basal values. Resuscitation with shed autologous blood (SAB) showed incomplete recovery of A0 and V0 diameters even 2 h after resuscitation (71 +/- 14% and 81 +/- 18%, respectively, of basal value), whereas other vessels did not change significantly. The behavior of A0 diameter coincided with the incomplete recovery of blood flow rates in all the vessels (ca. 50%) according to Poiseuille's law, and the incomplete recovery of functional capillary density (ca. 75%). Resuscitation with 8% human serum albumin in saline (HSA) tended to show higher levels of A0 constriction and A4 dilation and lowered blood flow rates. Resuscitation with SAB restored tissue PO2 27 +/- 10 mmHg after 2 h, which was near control levels (28 +/- 5 mmHg), whereas resuscitation with HSA caused tissue PO2 to remain significantly depressed (6 +/- 2 mmHg), and flow rates were significantly lower than resuscitation with SAB. These results indicate that response of the A0 vessels is the crucial determinant of blood flow in the observed area. The constriction of A0 may help sustain MAP, and constriction of V0 may enhance blood redistribution from the skin to the vital organs under the hypotensive condition. PMID- 9950859 TI - Modulation of repolarization in rabbit Purkinje and ventricular myocytes coupled by a variable resistance. AB - Purkinje-ventricular junctions (PVJs) have been implicated as potential sites of arrhythmogenesis, in part because of the dispersion of action potential duration (APD) between Purkinje (P) and ventricular (V) myocytes. To characterize electrotonic modulation of APD as a function of junctional resistance (Rj), we coupled single isolated rabbit P and V myocytes with an electronic circuit. In seven of eight PV myocyte pairs, both APDs shortened on coupling at Rj = 50 MOmega. This was in contrast to modulation of APD in paired ventricular myocytes, which demonstrated APD shortening of the intrinsically longer action potential and APD prolongation of the intrinsically shorter action potential. Companion computer simulations, performed to suggest possible mechanisms for the paradoxical shortening of the V action potential in paired P and V myocytes, showed that the difference in intrinsic peak plateau potentials (Vpp) of the P and V myocytes determined whether the V action potential shortened or prolonged on coupling. This difference in Vpp caused a large, repolarizing coupling current to flow to the V myocyte, contributing to early inactivation of the L-type calcium current and early activation of the inward rectifier current. These results suggest that intrinsic differences in phase 1 repolarization could yield differing patterns of APD shortening or prolongation in the network of subendocardial PVJs, leaving some PVJs vulnerable to conduction of premature stimuli while other PVJs remain refractory. PMID- 9950860 TI - Disparate effects of three types of extracellular acidosis on left ventricular function. AB - Effects of acidosis on muscle contractile function have been studied extensively. However, the relative effects of different types of extracellular acidosis on left ventricular (LV) contractile function, especially the temporal features of contraction, have not been investigated in a single model. We constituted perfusion buffers of identical ionic composition, including Ca2+ concentration ([Ca2+]), to mimic physiological control condition (pH 7.40) and three types of acidosis with pH of 7.03: inorganic (IA), respiratory (RA), and lactic (LA). Isolated rabbit hearts (n = 9) were perfused with acidotic buffers chosen at random, each preceded by the control buffer. Under steady-state conditions, instantaneous LV pressure (Pv) and volume (Vv) were recorded for a range of Vv. The results were as follows. 1) LV passive (end-diastolic) elastance increased with IA and RA. However, this increase may not be a direct effect of acidosis; it can be explained on the basis of myocardial turgor. 2) Although LV inotropic state (peak active Pv and elastance) was depressed by all three acidotic buffers, the magnitude of inotropic depression was significantly less for LA. 3) Temporal features of Pv were altered differently. Whereas IA and RA reduced time to peak Pv (tmax) and hastened isovolumic relaxation at a common level of LV wall stress, LA significantly increased tmax and retarded relaxation. These results and a model-based interpretation suggest that cooperative feedback (i.e., force activation interaction) plays an important role in acidosis-induced changes in LV contractile function. Furthermore, it is proposed that LA-induced responses comprise two components, one due to intracellular acidosis and the other due to pH-independent effects of lactate ions. PMID- 9950861 TI - Laminar fiber architecture and three-dimensional systolic mechanics in canine ventricular myocardium. AB - Previous studies suggest that the laminar architecture of left ventricular myocardium may be critical for normal ventricular mechanics. However, systolic three-dimensional deformation of the laminae has never been measured. Therefore, end-systolic finite strains relative to end diastole, from biplane radiography of transmural markers near the apex and base of the anesthetized open-chest canine anterior left ventricular free wall (n = 6), were referred to three-dimensional laminar microstructural axes reconstructed from histology. Whereas fiber shortening was uniform [-0.07 +/- 0.04 (SD)], radial wall thickening increased from base (0. 10 +/- 0.09) to apex (0.14 +/- 0.13). Extension of the laminae transverse to the muscle fibers also increased from base (0.08 +/- 0. 07) to apex (0.11 +/- 0.08), and interlaminar shear changed sign [0. 05 +/- 0.07 (base) and 0.07 +/- 0.09 (apex)], reflecting variations in laminar architecture. Nevertheless, the apex and base were similar in that at each site laminar extension and shear contributed approximately 60 and 40%, respectively, of mean transmural thickening. Kinematic considerations suggest that these dual wall thickening mechanisms may have distinct ultrastructural origins. PMID- 9950862 TI - beta-adrenergic modulation of L-type Ca2+-channel currents in early-stage embryonic mouse heart. AB - Little information is available concerning the modulation of cardiac function by beta-adrenergic agonists in early-stage embryonic mammalian heart. We have examined the effects of isoproterenol (Iso) on the spontaneous beating rate and action potential (AP) configuration in embryonic mouse hearts at 9.5 days postcoitum (dpc), just 1 day after they started to beat. Iso (3 microM) increased the spontaneous beating rate in whole hearts, dissected ventricles, and isolated ventricular myocytes. In ventricular myocytes, Iso also increased the slope of the pacemaker potential and the action potential duration but decreased the maximum upstroke velocity. In whole cell voltage-clamp experiments, the Ca2+ channel currents were measured as Ba2+ currents (IBa). In 9.5-dpc myocytes, IBa was enhanced significantly from -4.7 +/- 0.9 to -6.7 +/- 1.2 pA/pF (by 52.4 +/- 14.8%, n = 10) after the application of Iso. Propranolol (3 microM) reversed the effect of Iso. Forskolin (For, 10 microM) produced an increase in IBa by 95.5 +/- 18.8% (n = 8). In ventricular myocytes at a late embryonic stage (18 dpc), 3 microM Iso caused an appreciably greater increase in IBa from -6.2 +/- 0.5 to 14.5 +/- 2.2 pA/pF (by 137.8 +/- 33.0%, n = 8), whereas the increase in IBa by 10 microM For (by 120.0 +/- 23.0%, n = 7) was comparable to that observed in the early stage (9.5 dpc). These results indicate that the L-type Ca2+-channel currents are modulated by beta-adrenergic receptors in the embryonic mouse heart as early as 9.5 dpc, probably via a cAMP-dependent pathway. PMID- 9950863 TI - Extracellular signal-regulated kinases 1 and 2 activation in endothelial cells exposed to cyclic strain. AB - The aim of this study was to determine whether extracellular signal-regulated kinases 1/2 (ERK1/ERK2) are activated and might play a role in enhanced proliferation and morphological change induced by strain. Bovine aortic endothelial cells (BAEC) were subjected to an average of 6 or 10% strain at a rate of 60 cycles/min for up to 4 h. Cyclic strain caused strain- and time dependent phosphorylation and activation of ERK1/ERK2. Peak phosphorylation and activation of ERK1/ERK2 induced by 10% strain were at 10 min. A specific ERK1/ERK2 kinase inhibitor, PD-98059, inhibited phosphorylation and activation of ERK1/ERK2 but did not inhibit the increased cell proliferation and cell alignment induced by strain. Treatment of BAEC with 2,5-di-tert-butyl-1, 4 benzohydroquinone, to deplete inositol trisphosphate-sensitive calcium storage, and gadolinium chloride, a Ca2+ channel blocker, did not inhibit the activation of ERK1/ERK2. Strain-induced ERK1/ERK2 activation was partly inhibited by the protein kinase C inhibitor calphostin C and completely inhibited by the tyrosine kinase inhibitor genistein. These data suggest that 1) ERK1/ERK2 are not critically involved in the strain-induced cell proliferation and orientation, 2) strain-dependent activation of ERK1/ERK2 is independent of intracellular and extracellular calcium mobilization, and 3) protein kinase C activation and tyrosine kinase regulate strain-induced activation of ERK1/ERK2. PMID- 9950864 TI - Ca2+-independent inhibition of myocardial contraction by coronary effluent of hypoxic rat hearts. AB - Endothelial cells release agents that influence cardiac contraction. We recently reported that cultured hypoxic endothelial cells release an unidentified factor(s) that inhibits myocardial contraction. In this study, we investigated the effects of coronary effluent of isolated hypoxic rat hearts on isolated rat ventricular myocyte contraction. Coronary effluent collected during brief moderate hypoxia significantly depressed myocyte twitch shortening and decreased diastolic length, with only minor reduction in intracellular Ca2+ transients. These effects were similar to those of hypoxic rat coronary microvascular endothelial cell superfusates and were reversed by reoxygenation of hearts. "Hypoxic" coronary effluent exerted essentially Ca2+-independent effects on myofilament interaction in intact myocytes, as assessed by 1) peak Ca2+ shortening relations, 2) phase-plane analysis of instantaneous Ca2+-cell length relations, and 3) "steady-state" myofilament responses in tetanized, sarcoplasmic reticulum-disabled cells. Thus an unidentified substance(s) that inhibits myocyte shortening predominantly via effects on the myofilaments is reversibly released during acute moderate hypoxia of isolated hearts, presumably from coronary endothelial cells. Release of such an agent may be relevant to the cardiac contractile response to hypoxia. PMID- 9950865 TI - Endocardial endothelium mediates luminal ACh-NO signaling in isolated frog heart. AB - ACh exerted a biphasic effect in the in vitro working heart of Rana esculenta. High concentrations (10(-7) M) of ACh depressed stroke volume (SV) and stroke work (SW) by approximately 30% with a shorter systolic phase and reduced peak pressure. Doses from 10(-10) M induced a positive response peaking at 10(-8) M (SV: +8.6%; SW: +6. 5%) and a prolonged systolic phase without affecting peak pressure. Atropine and pirenzepine blocked both the positive and the negative effects of ACh. Pretreatment with Triton X-100 (0.1 ml, 0.05%) or with nitric oxide (NO)-cGMP pathway antagonists (NG-nitro-L-arginine, NG-nitro-L-arginine methyl ester, NG-monomethyl-L-arginine, and 1H-[1,2,4]oxadiazolo-[4,3 a]quinoxalin-1-one) abolished the positive and negative cholinergic effects. Infusion of 8-bromoguanosine 3', 5'-cyclic monophosphate reverted the positive effect of ACh to a negative effect. Milrinone blocked the positive inotropism but did not change the negative cholinergic response. The NO donor 3 morpholinosydnonimine generated a biphasic dose-response curve with a maximum positive effect at 10(-8) M (SV: +8%; SW: +5.6%; systolic phase: +28 ms) and a negative effect at 5 x 10(-8) M (SV and SW: about -12%; systolic phase: -70 ms; peak pressure: -1.50 mm). We conclude that in the avascular frog heart the endocardial endothelium mediates the inotropic effect of luminal cholinergic stimuli via a NO-cGMP pathway. PMID- 9950866 TI - Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. AB - The present study demonstrates that the alpha, epsilon, and iota isozymes of protein kinase C (PKC) are translocated to particulate fractions from the cytosol during brief intervals of global ischemia as well as reperfusion of ischemic rat myocardium. In contrast, phorbol ester treatment of perfused hearts resulted in the translocation of the alpha, delta, and epsilon isozymes of PKC to particulate fractions. Additionally, the alpha, delta, and epsilon isozymes of PKC are translocated to particulate fractions in phorbol ester-stimulated, isolated adult rat cardiac myocytes. Concomitant with the translocation of PKC isozymes to particulate fractions during myocardial ischemia, increased protein phosphorylation was observed, which was blocked by pretreatment of hearts with the selective PKC inhibitor bisindolylmaleimide I (50 nM). In particular, ischemia resulted in the phosphorylation of 26-, 20-, and 17-kDa particulate associated proteins. Taken together, the present findings are the first to demonstrate that specific PKC isozymes are translocated to particulate fractions in the ischemic and the reperfused ischemic rat heart, resulting in the phosphorylation of specific particulate-associated proteins. PMID- 9950867 TI - Modulation of arterial Na+-K+-ATPase-induced [Ca2+]i reduction and relaxation by norepinephrine, ET-1, and PMA. AB - Na+-K+-ATPase plays a major role in regulating membrane potential and vascular tone. We analyzed the modulation by norepinephrine (NE), endothelin-1 (ET-1), and phorbol 12-myristate 13-acetate (PMA) of Na+-K+-ATPase-induced cytoplasmic free Ca2+ concentration ([Ca2+]i) reduction and relaxation in isolated endothelium denuded piglet mesenteric arteries. KCl (0.2-8.8 mM)-induced [Ca2+]i reduction and relaxation in arteries incubated in K+-free solution were used as functional indicators of Na+-K+-ATPase activity. KCl-induced relaxations after exposure to K+-free solution were associated with a reduction in [Ca2+]i, as measured by fura 2 fluorescence. However, KCl reduced [Ca2+]i below resting values, whereas force was reduced to near resting values. NE, ET-1, and PMA inhibited the relaxant effects of KCl, and this effect was attenuated by the protein kinase C inhibitor staurosporine but not by the phospholipase A2 inhibitor quinacrine. However, ET-1 and PMA potentiated the [Ca2+]i-reducing effect of KCl. In conclusion, ET-1, PMA, and NE are functional inhibitors of Na+-K+-ATPase activity in endothelium-denuded piglet mesenteric arteries, even when the direct effect on the enzyme activity may be stimulatory rather than inhibitory. This can be explained because ET-1, PMA, and NE induce Ca2+ sensitization for smooth muscle contraction, and therefore relaxations do not parallel the reductions in [Ca2+]i after the activation of Na+-K+-ATPase. PMID- 9950868 TI - Effect of estrogen on aortic function in postmenopausal women. AB - We hypothesized that estrogen may alter aortic elastic properties. The aortic pressure-diameter relation was obtained in 20 postmenopausal women, 10 without (group 1) and 10 with (group 2) proven coronary artery disease, before and after intravenous administration of 10 micrograms of 17beta-estradiol. Instantaneous aortic diameter was measured by an intravascular catheter developed in our institution simultaneously with aortic pressure at the same aortic level with a catheter-tipped micromanometer. At baseline, elastic properties of the aorta were decreased in group 2 compared with group 1. Compared with baseline, aortic distensibility was increased in both groups (P < 0.01 and P < 0.05 for groups 1 and 2, respectively) after estrogen administration, whereas the pressure-diameter loop was shifted downward along a different hypothetical line of elasticity, suggesting active changes in the aortic elastic properties. Furthermore, a significant reduction in wave reflection was found in both groups (P < 0.001). This action may contribute to the beneficial effects of estrogen on the cardiovascular system and may have future therapeutic implications in postmenopausal women. PMID- 9950869 TI - Relative contribution of vasodilator prostanoids and NO to metabolic vasodilation in the human forearm. AB - Although many factors are thought to contribute to the regulation of metabolic vasodilation in skeletal muscle vasculature, recent interest has focused on the role of the endothelium. We examined the relative roles of nitric oxide (NO) and of vasodilator prostanoids in the control of metabolically induced functional hyperemia in the forearm of humans. In 43 healthy volunteers [24 +/- 5 (SD) yr] we assessed resting and functional hyperemic blood flow (FHBF) in response to 2 min of isotonic forearm exercise before and after inhibition of NO and/or vasodilator prostanoid production with intra-arterial NG-monomethyl-L-arginine (L NMMA, 2 mg/min) and aspirin (ASA, 3 mg/min), respectively. Blood flow was measured using venous occlusion plethysmography. L-NMMA and ASA decreased resting forearm blood flow by 42% (P < 0.0001) and 23% (P < 0.0001), respectively, whereas infusion of ASA followed by L-NMMA reduced flow by a further 24% (P < 0.05). L-NMMA reduced peak FHBF by 18% [from 13.9 +/- 1.0 to 11.4 +/- 1.1 (SE) ml. 100 ml forearm-1. min-1, P = 0.003] and the volume "repaid" after 1 and 5 min by 25% (8.9 +/- 0.7 vs. 6.7 +/- 0.7 ml/100 ml, P < 0.0001) and 37% (26.6 +/- 1.8 vs. 16.8 +/- 1.6 ml/100 ml, P < 0.0001). ASA similarly reduced peak FHBF by 19% (from 14.5 +/- 1.1 to 11.8 +/- 0.9. 100 ml forearm-1. min-1, P < 0.001) and the volume repaid after 1 and 5 min by 14% (7.5 +/- 0. 6 vs. 6.4 +/- 0.6 ml/100 ml, P = 0.0001) and 20% (21.2 +/- 1.5 vs. 16.9 +/- 1.5 ml/100 ml, P < 0.0001), respectively. The coinfusion of ASA and L-NMMA did not decrease FHBF to a greater extent than either agent alone. These data suggest that endothelium-derived NO and vasodilator prostanoids contribute to resting blood flow and metabolic vasodilation in skeletal muscle vasculature in healthy humans. Although these vasodilator mechanisms operate in parallel in exercise-induced hyperemia, they appear not to be additive. Other mechanisms must also be operative in metabolic vasodilation. PMID- 9950870 TI - Nonstressed rat model of acute endotoxemia that unmasks the endotoxin-induced TNF alpha response. AB - Previous investigators have demonstrated that the tumor necrosis factor-alpha (TNF-alpha) response to endotoxin is inhibited by exogenous corticosterone or catecholamines both in vitro and in vivo, whereas others have reported that surgical and nonsurgical stress increase the endogenous concentrations of these stress-induced hormones. We hypothesized that elevated endogenous stress hormones resultant from experimental protocols attenuated the endotoxin-induced TNF-alpha response. We used a chronically catheterized rat model to demonstrate that the endotoxin-induced TNF-alpha response is 10- to 50-fold greater in nonstressed (NS) rats compared with either surgical-stressed (SS, laparotomy) or nonsurgical stressed (NSS, tail vein injection) models. Compared with the NS group, the SS and NSS groups demonstrated significantly lower mean peak TNF-alpha responses at 2 mg/kg and 6 micrograms/kg endotoxin [NS 111.8 +/- 6.5 ng/ml and 64.3 +/- 5.9 ng/ml, respectively, vs. SS 3.9 +/- 1.1 ng/ml (P < 0.01) and 1.3 +/- 0.5 ng/ml (P < 0.01) or NSS 5.2 +/- 3.2 ng/ml (P < 0.01) at 6 micrograms/kg]. Similarly, baseline concentrations of corticosterone and catecholamines were significantly lower in the NSS group [84.5 +/- 16.5 ng/ml and 199.8 +/- 26.2 pg/ml, respectively, vs. SS group 257. 2 +/- 35.7 ng/ml (P < 0.01) and 467.5 +/- 52.2 pg/ml (P < 0.01) or NS group 168.6 +/- 14.4 ng/ml (P < 0.01) and 1,109.9 +/- 140.7 pg/ml (P < 0.01)]. These findings suggest that the surgical and nonsurgical stress inherent in experimental protocols increases baseline stress hormones, masking the endotoxin-induced TNF-alpha response. Subsequent studies of endotoxic shock should control for the effects of protocol-induced stress and should measure and report baseline concentrations of corticosterone and catecholamines. PMID- 9950872 TI - Downward gradient in action potential duration along conduction path in and around the sinoatrial node. AB - Regional differences in electrical activity in rabbit sinoatrial node have been investigated by recording action potentials throughout the intact node or from small balls of tissue from different regions. In the intact node, action potential duration was greatest at or close to the leading pacemaker and declined markedly in all directions from it, e.g., by 74 +/- 4% (mean +/- SE, n = 4) to the crista terminalis. Similar data were obtained from the small balls. The gradient is down the conduction pathway and will help prevent reentry. In the intact node, a zone of inexcitable tissue with small depolarizations of <25 mV or stable resting potentials was discovered in the inferior part of the node, and this will again help prevent reentry. The intrinsic pacemaker activity of the small balls was slower in tissue from more inferior (as well as more central) parts of the node [e.g., cycle length increased from 339 +/- 13 ms (n = 6) to 483 +/- 13 ms (n = 6) in transitional tissue from more superior and inferior sites], and this may help explain pacemaker shift. PMID- 9950871 TI - Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle. AB - mRNA expression of vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), and hypoxia-inducible factor (HIF) subunits HIF-1alpha and HIF 1beta in human skeletal muscle was studied during endurance exercise at different degrees of oxygen delivery. Muscle biopsies were taken before and after 45 min of one-legged knee-extension exercise performed under conditions of nonrestricted or restricted blood flow (approximately 15-20% lower) at the same absolute workload. Exercise increased VEGF mRNA expression by 178% and HIF-1beta by 340%, but not HIF-1alpha and FGF-2. No significant differences between the restricted and nonrestricted groups were observed. The exercise-induced increase in VEGF mRNA was correlated to the exercise changes in HIF-1alpha and HIF-1beta mRNA. The changes in VEGF, HIF-1alpha, and HIF-1beta mRNAs were correlated to the exercise induced increase in femoral venous plasma lactate concentration. It is concluded that 1) VEGF but not FGF-2 gene expression is upregulated in human skeletal muscle by a single bout of dynamic exercise and that there is a graded response in VEGF mRNA expression related to the metabolic stress and 2) the increase in VEGF mRNA expression correlates to the changes in both HIF-1alpha and HIF-1beta mRNA. PMID- 9950873 TI - Maintained upregulation of pulmonary eNOS gene and protein expression during recovery from chronic hypoxia. AB - We previously demonstrated augmented endothelium-derived nitric oxide (EDNO) dependent pulmonary arterial dilation and increased arterial endothelial nitric oxide synthase (eNOS) levels in chronic hypoxic (CH) and monocrotaline (nonhypoxic) models of pulmonary arterial hypertension. Therefore, we hypothesized that the long-term elevation of arterial eNOS levels associated with CH is related to pulmonary hypertension or some factor(s) associated with hypertension and not directly to hypoxia. To test this hypothesis, we examined responses to the EDNO-dependent dilator ionomycin in U-46619-constricted, isolated, saline-perfused lungs from control rats, CH (4 wk at 380 mmHg) rats, and rats previously exposed to CH but returned to normoxia for 4 days or 2 wk. Microvascular pressure was assessed by double-occlusion technique, allowing calculation of segmental resistances. In addition, vascular eNOS immunoreactivity was assessed by quantitative immunohistochemistry, and eNOS mRNA abundance was determined by RT-PCR assays. Our findings indicate that 4-day and 2-wk posthypoxic rats exhibit persistent pulmonary hypertension, likely due to maintained arterial remodeling and polycythemia associated with prior exposure to CH. Furthermore, arterial dilation to ionomycin was augmented in lungs from each experimental group compared with controls. Finally, arterial eNOS immunoreactivity and whole lung eNOS mRNA levels remained elevated in posthypoxic animals. These findings suggest that altered vascular mechanical forces or vascular remodeling contributes to enhanced EDNO-dependent arterial dilation and upregulation of arterial eNOS in various models of established pulmonary hypertension. PMID- 9950874 TI - Subcellular localization of the Na+/H+ exchanger NHE1 in rat myocardium. AB - The Na+/H+ exchanger NHE1 isoform is an integral component of cardiac intracellular pH homeostasis that is critically important for myocardial contractility. To gain further insight into its physiological significance, we determined its cellular distribution in adult rat heart by using immunohistochemistry and confocal microscopy. NHE1 was localized predominantly at the intercalated disk regions in close proximity to the gap junction protein connexin 43 of atrial and ventricular muscle cells. Significant labeling of NHE1 was also observed along the transverse tubular systems, but not the lateral sarcolemmal membranes, of both cell types. In contrast, the Na+-K+-ATPase alpha1 subunit was readily labeled by a specific mouse monoclonal antibody (McK1) along the entire ventricular sarcolemma and intercalated disks and, to a lesser extent, in the transverse tubules. These results indicate that NHE1 has a distinct distribution in heart and may fulfill specialized roles by selectively regulating the pH microenvironment of pH-sensitive proteins at the intercalated disks (e.g., connexin 43) and near the cytosolic surface of sarcoplasmic reticulum cisternae (e.g., ryanodine receptor), thereby influencing impulse conduction and excitation contraction coupling. PMID- 9950876 TI - Central Fos expression in fetal and adult sheep after intraperitoneal hypertonic saline. AB - We hypothesized that neural structures, involved in sensing extracellular body fluid composition in adult animals during an osmotic challenge, would show similar patterns of activation in fetal sheep. Eight adult sheep [4 hypertonic saline-treated adults (HYP-A), 4 isotonic saline-treated adults] and six near term fetal sheep [3 hypertonic saline-treated fetuses (HYP-F), 3 isotonic saline treated fetuses; 130 days gestation] were prepared with vascular and intraperitoneal catheters. Seventy-five minutes before tissue collection, hypertonic (1.5 M) or isotonic saline was infused via an intraperitoneal catheter to adult (18 ml/kg) or fetal sheep (6 ml/kg). Brains were examined for patterns of neuronal activation (demonstrated by Fos protein expression). HYP-A and HYP-F demonstrated similar acute increases in plasma osmolality ( approximately 10 mosmol/kgH2O) and comparable patterns of Fos expression within the organum vasculosum of the lamina terminalis (HYP-A, 67 +/- 2 vs. HYP-F, 63 +/- 6; means +/- SE) and hypothalamic supraoptic (SON; HYP-A, 107 +/- 8 vs. HYP-F, 102 +/- 7) and paraventricular nuclei (PVN; HYP-A, 71 +/- 18 vs. HYP-F, 124 +/- 19). Fewer activated neurons were detected in HYP-A vs. HYP-F within the subfornical organ (HYP-A, 33 +/- 8 vs. HYP-F, 91 +/- 17) and median preoptic nucleus (HYP-A, 33 +/- 5 vs. HYP-F, 70 +/- 6). In adults and fetuses, counterstaining for arginine vasopressin revealed that neurons within the SON and PVN respond to osmotic challenge. These findings demonstrate that central osmoregulatory centers in adult and near-term fetal sheep are similarly activated by osmotic challenge. PMID- 9950875 TI - Intracellular gradients of O2 supply to mitochondria in actively respiring single cardiomyocyte of rats. AB - We demonstrated in a previous study [Takahashi, E., K. Sato, H. Endoh, Z.-L. Xu, and K. Doi. Am. J. Physiol. 275 (Heart Circ. Physiol. 44): H225-H233, 1998] that significant radial gradients of intracellular PO2 may be produced in an uncoupled actively respiring, single isolated cardiomyocyte of the rat. The present study was designed to further determine whether such intracellular PO2 gradients can be a limiting factor of oxidative metabolism in uncoupled cardiomyocytes. The NAD(P)H fluorescence of a single cardiomyocyte was captured by a digital charge coupled device camera and quantitated with a subcellular spatial resolution by a ratio-imaging technique. In the conditions that we demonstrated significant radial PO2 gradients (cells treated with 1 microM carbonyl cyanide m chlorophenylhydrazone and superfused with 2.09% or 3.14% O2 gas at 27 degreesC), we demonstrated significant augmentation of NAD(P)H fluorescence near the core of an individual cell. The heterogeneous fluorescence pattern was not found in the control cell, whereas fluorescence intensity averaged over the cell was increased by hypoxia. These results suggest the possibility that oxidative phosphorylation near the core of actively respiring, uncoupled cardiomyocytes may be severely suppressed due to insufficient diffusional oxygen supply (hypoxic core) even if regions near the sarcolemma are adequately oxygenated. PMID- 9950877 TI - Cadherin-5 redistribution at sites of TNF-alpha and IFN-gamma-induced permeability in mesenteric venules. AB - The response of the endothelial permeability barrier in microvascular networks of the rat mesentery to perfused immune inflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) was examined. TNF-alpha (12.5 U/ml) treatment did not change albumin permeability, but in combination with IFN gamma (20 U/ml), there was a marked increase in the number of sites of extravascular albumin in postcapillary venules. Endothelial integrity was characterized by cadherin-5 immunoreactivity, which was localized to the continuous intercellular junctions of endothelium in arterioles, capillaries, and venules. Perfusion with the combined cytokines showed that the increased albumin permeability was dose dependent and correlated with the focal disorganization of cadherin-5 at intercellular junctions of venular endothelium. No correlation was found between the increase in albumin permeability and the localization of intravascular leukocytes or extravascular mast cells. These results show that the combination of TNF-alpha and IFN-gamma induces an endothelial phenotype with focal loss of cadherin-5 intercellular adhesion, which, in part, facilitates passage of blood macromolecules and cells to the interstitium. PMID- 9950879 TI - Real-time measurement of cardiac vagal tone in conscious dogs. AB - Rapid changes in heart rate are caused by changes in parasympathetic tone. The NeuroScope is an electronic device designed to offer an objective real-time measure of instantaneous cardiac vagal tone by phase demodulation of a high resolution time domain of R-R wave intervals. Data are displayed against an arbitrary but linear scale, the cardiac index of parasympathetic activity (CIPA). To validate this method, 10 conscious healthy dogs were each given six incremental doses of atropine (0.01 mg/kg) to a total dose of 0.06 mg/kg or equal volumes of saline. A dose-response curve was constructed. At the maximum dose of atropine, CIPA values fell to 1. 3 +/- 0.7% (SD) of baseline, whereas R-R intervals fell to 51.5 +/- 11.5% of baseline, and standard deviation of the R-R wave interval fell to 10.6 +/- 6.5% of baseline. These findings show that the NeuroScope can provide a specific real-time index of cardiac vagal tone in dogs without need for recourse to atropine. PMID- 9950878 TI - Orally administered NHE1 inhibitor cariporide reduces acute responses to coronary occlusion and reperfusion. AB - Na+/H+ exchange (NHE) mediates myocardial ischemic and reperfusion injury. We examined the effects of dietary administration of the potent and selective NHE1 inhibitor cariporide on acute responses to coronary artery ligation and reperfusion in the anesthetized rat. Male Sprague-Dawley rats received control rat chow or an identical diet containing 3 parts per million of cariporide for 1 wk before 225 min of occlusion of the left main coronary artery or 45 min of occlusion followed by 180 min of reperfusion. Hearts were excised and divided into left ventricle, right ventricle, and interventricular septum for analysis of NHE1 mRNA expression and apoptosis by staining with terminal deoxynucleotidyl transferase-mediated nick end labeling. Ischemia and reperfusion were associated with a threefold elevation in NHE1 mRNA expression in control animals that was significantly reduced in cariporide-fed rats. Cariporide reduced mortality from 26% of animals to 0%. The incidence of all arrhythmias was significantly reduced, including ventricular fibrillation (from 42 to 0%) and ventricular tachycardia (from 81 to 15%), as well as the number of ventricular premature beats (from 70 +/- 12 to 17 +/- 6). Cariporide moderately reduced apoptosis only in the reperfused left ventricle to values not significantly greater than those in sham operated animals, and this was associated with a significantly higher ratio of Bcl-2 to Bax. This study suggests that NHE inhibition with dietary cariporide represents an effective management of acute postinfarction responses. PMID- 9950880 TI - Presence of hemoglobin inside aortic endothelial cells after cell-free hemoglobin administration in guinea pigs. AB - The endothelium is the production site of several potent vasoactive factors that contribute to the modulation of the vascular tone. Because hemoglobin-based oxygen carriers (HBOC) have been demonstrated to cause vasoconstriction and thereby increase arterial pressure by interacting with endothelium-derived factors such as nitric oxide and endothelin-1, we hypothesized that hemoglobin could penetrate into the endothelial cells. Therefore, we investigated the presence of hemoglobin into guinea pig aortic endothelial cells by immunohistochemical staining after exchange transfusion with a hemoglobin-based oxygen carrier. Despite the large molecular size of HBOC due to chemical modifications designed to prevent hemoglobin subunit dissociation and extravascular leakage, hemoglobin was detectable by immunohistochemical staining into the endothelial cells. These findings suggest that the vascular endothelial cells could uptake hemoglobin by endocytosis mechanisms or could help hemoglobin to cross the endothelial barrier toward media by transcytosis mechanisms. These findings are very important to lead future investigations to the mechanisms by which HBOC cause vasoconstriction. PMID- 9950881 TI - Blood yield stress in systemic sclerosis. AB - Blood is a weak percolating physical gel at low shear rates, in which clusters of aggregates can be reversibly disaggregated or formed again. This phenomenon is of potential importance in the microvascular pathophysiology of ischemic and vasospastic disorders such as systemic sclerosis. The aim of this work was to determine blood yield stress using low-shear-rate rheometry with a homemade roughened Couette device in 10 patients with systemic sclerosis compared with 10 healthy controls. Biochemical plasmatic parameters were assessed independently. Results showed a significantly increased stress (+56%, P < 0.05 at 60% hematocrit) for scleroderma patients. The best biochemical predictor for yield stress was the ratio of albumin to globulins; 69% of its variance was explained by plasmatic factors (albumin, fibrinogen, and globulins) in scleroderma patients and 23.4% in healthy controls. Additional microscopic observations showed different microstructures. These results support the hypothesis of an abnormal red blood cell organization process in scleroderma patients that could be partly responsible for the severity of ischemic complications of the disease. PMID- 9950882 TI - Effects of fluoxetine, phentermine, and venlafaxine on pulmonary arterial pressure and electrophysiology. AB - The anorexic agents dexfenfluramine and fenfluramine plus phentermine have been associated with outbreaks of pulmonary hypertension. The fenfluramines release serotonin and reduce serotonin reuptake in neurons. They also inhibit potassium current (IK), causing membrane potential depolarization in pulmonary arterial smooth muscle cells. The recent withdrawal of the fenfluramines has led to the use of fluoxetine and phentermine as an alternative anorexic combination. Because fluoxetine and venlafaxine reduce serotonin reuptake, we compared the effects of these agents with those of phentermine and dexfenfluramine on pulmonary arterial pressure, IK, and membrane potential. Fluoxetine, venlafaxine, and phentermine caused minimal increases in pulmonary arterial pressure at concentrations < 100 microM but did cause a dose-dependent inhibition of IK. The order of potency for inhibition of IK at +50 mV was fluoxetine > dexfenfluramine = venlafaxine > phentermine. Despite the inhibitory effect on IK at more positive membrane potentials, fluoxetine, venlafaxine, and phentermine, in contrast to dexfenfluramine, had minimal effects on the cell resting membrane potential (all at a concentration of 100 microM). However, application of 100 microM fluoxetine to cells that had been depolarized to -30 mV by current injection elicited a further depolarization of >18 mV. These results suggest that fluoxetine, venlafaxine, and phentermine do not inhibit IK at the resting membrane potential. Consequently, they may present less risk of inducing pulmonary hypertension than the fenfluramines, at least by mechanisms involving membrane depolarization. PMID- 9950883 TI - K+-channel blockade inhibits shear stress-induced pulmonary vasodilation in the ovine fetus. AB - To determine whether K+-channel activation mediates shear stress-induced pulmonary vasodilation in the fetus, we studied the hemodynamic effects of K+ channel blockers on basal pulmonary vascular resistance and on the pulmonary vascular response to partial compression of the ductus arteriosus (DA) in chronically prepared late-gestation fetal lambs (128-132 days gestation). Study drugs included tetraethylammonium (TEA; Ca2+-dependent K+-channel blocker), glibenclamide (Glib; ATP-dependent K+-channel blocker), charybdotoxin (CTX; preferential high-conductance Ca2+-dependent K+-channel blocker), apamin (Apa; low-conductance Ca2+-dependent K+-channel blocker), and 4-aminopyridine (4-AP; voltage-dependent K+-channel blocker). Catheters were inserted in the left pulmonary artery (LPA) for selective drug infusion and in the main pulmonary artery, aorta, and left atrium to measure pressure. An inflatable vascular occluder was placed around the DA. LPA flow was measured with an ultrasonic flow transducer. Animals were treated with saline, high- or low-dose TEA, Glib, Apa, CTX, CTX plus Apa, or 4-AP injected into the LPA. DA compression caused a time related decrease in pulmonary vascular resistance in the control, Glib, Apa, CTX, CTX plus Apa, and low-dose TEA groups but not in the high-dose TEA and 4-AP groups. These data suggest that pharmacological blockade of Ca2+- and voltage dependent K+-channel activity but not of low-conductance Ca2+- and ATP-dependent K+-channel activity attenuates shear stress-induced fetal pulmonary vasodilation. PMID- 9950884 TI - NK1-receptor activation prevents hydrocarbon-induced lung injury in mice. AB - Recent evidence suggests that neurokinin (NK)-receptor activation may have a protective role in maintaining lung integrity when challenged by airborne toxicants such as sulfur dioxide, ozone, acrolein, or hydrocarbons. To investigate the effect of NK1-receptor activation on hydrocarbon-induced lung injury, B6.A.D. (Ahr d/Nats) mice received subchronic exposures to JP-8 jet fuel (JP-8). Lung injury was assessed by the analysis of pulmonary physiology, bronchoalveolar lavage fluid, and morphology. Hydrocarbon exposure to target JP-8 concentrations of 50 mg/m3, with saline treatment, was characterized by enhanced respiratory permeability to 99mTc-labeled diethylenetriaminepentaacetic acid, alveolar macrophage toxicity, and bronchiolar epithelial damage. Mice administered [Sar9,Met(O2)11]substance P, an NK1-receptor agonist, after each JP 8 exposure had the appearance of normal pulmonary values and tissue morphology. In contrast, endogenous NK1-receptor antagonism by CP-96345 administration exacerbated JP-8-enhanced permeability, alveolar macrophage toxicity, and bronchiolar epithelial injury. These data indicate that NK1-receptor activation may have a protective role in preventing the development of hydrocarbon-induced lung injury, possibly through the modulation of bronchiolar epithelial function. PMID- 9950885 TI - Alterations in lung expansion affect surfactant protein A, B, and C mRNA levels in fetal sheep. AB - Obstruction of the fetal trachea is a potent stimulus for fetal lung growth, and it has been suggested that this procedure may be used therapeutically to reverse lung growth deficits in human fetuses with lung hypoplasia. However, little is known about the effects of increased lung expansion on other aspects of lung development. Our aim was to determine the effect of increased and decreased lung expansion on the mRNA levels encoding surfactant protein (SP) A, SP-B, and SP-C in ovine fetal lungs. Lung tissue samples were collected from fetuses exposed to 2, 4, or 10 days of increased lung expansion caused by tracheal obstruction. The mRNA levels for SP-A, SP-B, and SP-C were determined by Northern blot analysis with specific ovine cDNA probes; SP-A protein levels were determined by Western blot analysis. Compared with age-matched (128-day gestational age) control fetuses, SP-A, SP-B, and SP-C mRNA levels in fetal lung tissue were significantly reduced at 2 days of tracheal obstruction and remained reduced at 4 and 10 days. However, SP-A protein levels were not reduced at 2 days of tracheal obstruction, tended to be reduced at 4 days, and were almost undetectable at 10 days. In contrast to tracheal obstruction, 7 days of lung liquid drainage significantly increased SP-C, but not SP-A, mRNA levels in fetal lung tissue compared with age matched control fetuses. Our results demonstrate that increases in fetal lung expansion, induced by obstruction of the fetal trachea, cause large simultaneous reductions in SP-A, SP-B, and SP-C mRNA levels in the fetal lung as well as a decrease in SP-A protein levels. These data suggest that expression of the genes encoding SPs in the fetal lung are specifically responsive to the degree of lung expansion. PMID- 9950886 TI - EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells. AB - The epidermal growth factor (EGF)-receptor (EGFR) family includes four homologous transmembrane receptor protein tyrosine kinases, EGFR, ErbB-2, ErbB-3, and ErbB 4. This receptor family plays a pivotal role in regulating cell proliferation, differentiation, and transformation. Ligand-induced activation of these receptors results in formation of homo- and heterodimers, which undergo transphosphorylation and transactivation. The aim of this study was to characterize the role of EGFR family members in signaling EGF-induced human airway smooth muscle (HASM) cell proliferation. Here, we show that EGF stimulates activation of EGFR and transactivation of ErbB-2 in quiescent HASM cells. Phosphatidylinositol (PI) 3-kinase, a critical signaling enzyme that modulates HASM cell growth, is preferentially associated with ErbB-2, and EGF-stimulated transactivation of ErbB-2 induces PI 3-kinase activation. ErbB-3 and ErbB-4 are present in HASM cells; however, EGF has no effect on their activation. Betacellulin, a ligand for EGFR, ErbB-3, and ErbB-4, induced DNA synthesis of HASM cells and stimulated signaling through the activation of EGFR and ErbB-2 but not of ErbB-3 and ErbB-4. Heregulin, a specific ligand for ErbB-3 and ErbB-4, did not effect DNA synthesis and did not activate its specific receptors. These data suggest that EGF imparts signals that involve activation of ErbB-2 and are associated with ErbB-2 PI 3-kinase activation. Despite the mRNA and protein expression of all members of the EGFR family, ligand-stimulated signaling induced activation of EGFR and ErbB-2 but not of ErbB-3 and ErbB-4. PMID- 9950887 TI - Production of interferon-gamma by lung lymphocytes in HIV-infected individuals. AB - A CD8(+) lymphocytic alveolitis occurs in up to 60% of asymptomatic human immunodeficiency virus (HIV)-infected individuals. Early in HIV infection, lymphocytes consist predominantly of cytotoxic T lymphocytes directed against HIV infected targets. As HIV disease progresses, they are replaced by CD8(+)CD57(+) suppressor cells. Virus-specific cytotoxic T lymphocytes secrete interferon-gamma (IFN-gamma), an important cytokine in upregulating immune responses, primarily through macrophage activation. We examined the ability of lung and blood lymphocytes from HIV-positive patients at various stages of HIV infection to secrete IFN-gamma spontaneously and in response to phytohemagglutinin A. IFN gamma production and secretion were determined with ELISA, Western blot, immunoprecipitation, and Northern blot techniques. Lung lymphocytes from HIV infected individuals secreted large amounts of IFN-gamma. However, this ability was lost in patients with late-stage disease. Correlation between blood and lung lymphocyte IFN-gamma secretion was poor, suggesting regional differences in lymphocyte function. These data suggest that lung levels of IFN-gamma are high until late in HIV disease. These findings support the concept of administering exogenous IFN-gamma to patients with late-stage HIV disease and opportunistic infections. PMID- 9950888 TI - Nitric oxide participates in early events associated with NNMU-induced acute lung injury in rats. AB - In this study, the biochemical mechanisms by which N-nitroso-N-methylurethane (NNMU) induces acute lung injury are examined. Polymorphonuclear neutrophil infiltration into the lungs first appears in the bronchoalveolar lavage (BAL) fluid 24 h after NNMU injection (10.58 +/- 3.00% of total cells; P < 0.05 vs. control animals). However, NNMU-induced elevation of the alveolar-arterial O2 difference requires 72 h to develop. Daily intraperitoneal injections of the inducible nitric oxide (. NO) synthase (iNOS)-selective inhibitor aminoguanidine (AG) initiated 24 h after NNMU administration improve the survival of NNMU treated animals. However, AG administration initiated 48 or 72 h after NNMU injection does not significantly improve the survival of NNMU-treated animals. These results suggest that. NO participates in events that occur early in NNMU induced acute lung injury. BAL cells isolated from rats 24 and 48 h after NNMU injection produce elevated. NO and express iNOS during a 24-h ex vivo culture. AG attenuates. NO production but does not affect iNOS expression, whereas actinomycin D prevents iNOS expression and attenuates. NO production by BAL cells during this ex vivo culture. These results suggest that NNMU-derived BAL cells can stimulate iNOS expression and. NO production during culture. In 48-h NNMU exposed rats, iNOS expression is elevated in homogenates of whole lavaged lungs but not in BAL cells derived from the same lung. These findings suggest that the pathogenic mechanism by which NNMU induces acute lung injury involves BAL cell stimulation of iNOS expression and. NO production in lung tissue. PMID- 9950889 TI - Role of neutrophils and alpha1-antitrypsin in coal- and silica-induced connective tissue breakdown. AB - Mineral dusts produce emphysema, and administration of dust to rats results in the rapid appearance of desmosine and hydroxyproline in lavage fluid, confirming that dusts directly induce connective tissue breakdown. To examine the role of neutrophils and alpha1-antitrypsin (alpha1-AT) in this process, we instilled silica or coal into normal rats or rats that had been pretreated with antiserum against neutrophils. One day after dust exposure, lavage fluid neutrophils and desmosine and hydroxyproline levels were all elevated; treatment with antiserum against neutrophils reduced neutrophils by 75%, desmosine by 40-50%, and hydroxyproline by 25%. By 7 days, lavage fluid neutrophils and desmosine level had decreased, whereas macrophages and hydroxyproline level had increased. By ELISA analysis, lavage fluid alpha1-AT levels were increased four- to eightfold at both times. On Western blot, some of the alpha1-AT appeared as degraded fragments, and by HPLC analysis, 5-10% of the methionine residues were oxidized. At both times, lavage fluid exhibited considerably elevated serine elastase inhibitory capacity and also showed elevations in metalloelastase activity. We conclude that, in this model, connective tissue breakdown is initially driven largely by neutrophil-derived proteases and that markedly elevated levels of functional alpha1-AT do not prevent breakdown, thus providing in vivo support for the concept of quantum proteolysis proposed by Liou and Campbell (T. G. Liou and E. J. Campbell. Biochemistry 34: 16171-16177, 1995). Macrophage-derived proteases may be of increasing importance over time, especially in coal-treated animals. PMID- 9950890 TI - Airway synthesis of 20-hydroxyeicosatetraenoic acid: metabolism by cyclooxygenase to a bronchodilator. AB - Rabbit airway tissue is a particularly rich source of cytochrome P-4504A protein, but very little information regarding the effect(s) of 20-hydroxyeicosatetraenoic acid (20-HETE) on bronchial tone is available. Our studies examined the response of rabbit bronchial rings to 20-HETE and the metabolism of arachidonic acid and 20-HETE from airway microsomes. 20-HETE (10(-8) to 10(-6) M) produced a concentration-dependent relaxation of bronchial rings precontracted with KCl or histamine but not with carbachol. Relaxation to 20-HETE was blocked by indomethacin or epithelium removal, consistent with the conversion of 20-HETE to a bronchial relaxant by epithelial cyclooxygenase. A cyclooxygenase product of 20 HETE also elicited relaxation of bronchial rings. [14C]arachidonic acid was converted by airway microsomes to products that comigrated with authentic 20-HETE (confirmed by gas chromatography-mass spectrometry as 19- and 20-HETE) and to unidentified polar metabolites. [3H]20-HETE was metabolized to indomethacin inhibitable products. These data suggest that 20-HETE is an endogenous product of rabbit airway tissue and may modulate airway resistance in a cyclooxygenase dependent manner. PMID- 9950891 TI - Determination of low-molecular-mass antioxidant concentrations in human respiratory tract lining fluids. AB - Antioxidants present within lung epithelial lining fluids (ELFs) constitute an initial line of defense against inhaled environmental oxidants such as ozone, nitrogen oxides, and tobacco smoke, but the antioxidant composition of human ELFs is still incompletely characterized. We analyzed ELF concentrations of the low molecular-mass antioxidants ascorbate, urate, glutathione (GSH), and alpha tocopherol by obtaining bronchoalveolar lavage (BAL) and nasal lavage fluids from healthy nonsmoking volunteers and compared two different BAL procedures. ELF dilution by the lavage procedures was estimated by measurement of urea in recovered BAL fluids in comparison with those in blood plasma from the same subjects. The results indicated that a recently developed single-cycle BAL procedure minimizes influx of non-ELF urea into the instilled fluid and thus allows for a more accurate determination of ELF antioxidant concentrations. Using this procedure, we determined that bronchoalveolar ELF contains 40 +/- 18 (SD) microM ascorbate, 207 +/- 167 microM urate, 109 +/- 64 microM GSH, and 0.7 +/- 0.3 microM alpha-tocopherol (n = 12 subjects). Similar analysis of nasal lavage fluid yielded nasal ELF levels of 28 +/- 19 microM ascorbate and 225 +/- 105 microM urate (n = 12 subjects), whereas GSH was undetectable (<0.5 microM). Our results demonstrate that ascorbate and urate are major low-molecular-mass ELF antioxidants in both the upper and lower respiratory tract, whereas GSH is present at significant concentrations only in bronchoalveolar ELF. PMID- 9950892 TI - Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension. AB - Endothelial nitric oxide (NO) synthase (eNOS) mRNA and protein and NO production are increased in hypoxia-induced hypertensive rat lungs, but it is uncertain whether eNOS gene expression and activity are increased in other forms of rat pulmonary hypertension. To investigate these questions, we measured eNOS mRNA and protein, eNOS immunohistochemical localization, perfusate NO product levels, and NO-mediated suppression of resting vascular tone in chronically hypoxic (3-4 wk at barometric pressure of 410 mmHg), monocrotaline-treated (4 wk after 60 mg/kg), and fawn-hooded (6-9 mo old) rats. eNOS mRNA levels (Northern blot) were greater in hypoxic and monocrotaline-treated lungs (130 and 125% of control lungs, respectively; P < 0.05) but not in fawn-hooded lungs. Western blotting indicated that eNOS protein levels increased to 300 +/- 46% of control levels in hypoxic lungs (P < 0.05) but were decreased by 50 +/- 5 and 60 +/- 11%, respectively, in monocrotaline-treated and fawn-hooded lungs (P < 0.05). Immunostaining showed prominent eNOS expression in small neomuscularized arterioles in all groups, whereas perfusate NO product levels increased in chronically hypoxic lungs (3.4 +/- 1.4 microM; P < 0.05) but not in either monocrotaline-treated (0.7 +/- 0.3 microM) or fawn-hooded (0.45 +/- 0.1 microM) lungs vs. normotensive lungs (0.12 +/- 0.07 microM). All hypertensive lungs had increased baseline perfusion pressure in response to nitro-L-arginine but not to the inducible NOS inhibitor aminoguanidine. These results indicate that even though NO activity suppresses resting vascular tone in pulmonary hypertension, there are differences among the groups regarding eNOS gene expression and NO production. A better understanding of eNOS gene expression and activity in these models may provide insights into the regulation of this vasodilator system in various forms of human pulmonary hypertension. PMID- 9950893 TI - Endothelin-1 is elevated in monocrotaline pulmonary hypertension. AB - These studies document striking pulmonary vasoconstrictor response to nitric oxide synthase (NOS) inhibition in monocrotaline (MCT) pulmonary hypertension in rats. This constriction is caused by elevated endothelin (ET)-1 production acting on ETA receptors. Isolated, red blood cell plus buffer-perfused lungs from rats were studied 3 wk after MCT (60 mg/kg) or saline injection. MCT-injected rats developed pulmonary hypertension, right ventricular hypertrophy, and heightened pulmonary vasoconstriction to ANG II and the NOS inhibitor NG-monomethyl-L arginine (L-NMMA). In MCT-injected lungs, the magnitude of the pulmonary pressor response to NOS inhibition correlated strongly with the extent of pulmonary hypertension. Pretreatment of isolated MCT-injected lungs with combined ETA (BQ 123) plus ETB (BQ-788) antagonists or ETA antagonist alone prevented the L-NMMA induced constriction. Addition of ETA antagonist reversed established L-NMMA induced constriction; ETB antagonist did not. ET-1 concentrations were elevated in MCT-injected lung perfusate compared with sham-injected lung perfusate, but ET 1 levels did not differ before and after NOS inhibition. NOS inhibition enhanced hypoxic pulmonary vasoconstriction in both sham- and MCT-injected lungs, but the enhancement was greater in MCT-injected lungs. Results suggest that in MCT pulmonary hypertension, elevated endogenous ET-1 production acting through ETA receptors causes pulmonary vasoconstriction that is normally masked by endogenous NO production. PMID- 9950894 TI - Pirfenidone inhibits PDGF isoforms in bleomycin hamster model of lung fibrosis at the translational level. AB - Pirfenidone (PD) is known for its antifibrotic effects in the bleomycin (BL) hamster model of lung fibrosis. We evaluated whether pretreatment of hamsters with PD could influence the effects of BL-induced overexpression of platelet derived growth factor (PDGF)-A and PDGF-B genes and proteins in the same model of lung fibrosis. We demonstrate elevated levels of PDGF-A and PDGF-B mRNAs in bronchoalveolar lavage (BAL) cells from lungs of BL-treated compared with saline control hamsters by RT-PCR analysis. However, these levels were not altered in BAL cells obtained from BL-treated hamsters on diets containing 0.5% PD. Western blot analysis of BAL fluid for PDGF isoforms demonstrated that PD treatment inhibited the synthesis of both PDGF-A and PDGF-B isoforms. PD treatment also decreased the mitogenic activity in the BAL fluid from BL-treated hamster lungs. Taken together, these data provide evidence that the protective effects of PD against BL-induced lung fibrosis may be mediated by a reduction in PDGF isoforms produced by lung macrophages. PMID- 9950895 TI - Identification of glucocorticoid-responsive elements that control transcription of rat glutamine synthetase. AB - Basal expression of glutamine synthetase (GS) is very low in rat lung and muscle and remarkably enhanced by glucocorticoid hormones during trauma and catabolic states. Although this response is believed to be transcriptionally regulated, the genetic elements responsible for tissue-specific glucocorticoid induction of GS expression have not been identified. A rat lung epithelial cell line (L2) and a glucocorticoid receptor-deficient human prostate cancer cell line (PC3), together with GS reporter gene constructs, were utilized in gene transfer experiments to identify two regions within the rat genomic clone gGS3 that imparted dexamethasone (Dex) responsiveness to both the homologous GS promoter and the heterologous herpes simplex virus thymidine kinase promoter in glucocorticoid receptor-dependent fashions. One region lies nearly 6 kb upstream of the GS transcription initiation site, and the other lies within the first intron of the GS gene. Dex responsiveness was localized to a 325-bp fragment of the intron region containing a canonical glucocorticoid response element and to a 225-bp fragment of the far-upstream region containing three separate glucocorticoid response element half-sites. The GS promoter exhibited relatively high basal activity that was repressed by inclusion of the far-upstream or the intron glucocorticoid-responsive region. Dex treatment negated this repression. A model is suggested in which the glucocorticoid-receptor unit causes derepression of lung and muscle GS transcription during trauma and catabolic states. PMID- 9950896 TI - O3-induced inflammation in prepregnant, pregnant, and lactating rats correlates with O3 dose estimated by 18O. AB - Previous studies have shown that rats late in pregnancy and throughout lactation are more susceptible to ozone (O3)-induced pulmonary inflammation than are prepregnant (virgin) or postlactating rats. The major aim of the present study was to determine whether these differences in response intensity could be accounted for by the O3 dose to the lower region of the lung. The relative O3 dose to the lower lung of groups of pregnant, lactating, and virgin female rats was estimated by measuring the incorporation of the 18O isotope into low-speed (cells) and high-speed (surfactant) pellets of bronchoalveolar lavage fluid immediately after acute exposure to 0.5-1.1 parts/million 18O3. The polymorphonuclear leukocyte (PMN) and protein inflammatory responses were established 20 h after acute exposure of identical physiological groups to 0.5 1.1 parts/million 16O3 (common isotope). A single regression of PMN inflammation data against surfactant 18O concentration for all physiological groups gave a linear relationship, indicating direct proportionality of PMN inflammation with this estimate of relative dose to the lower lung regardless of physiological status. This implies that the chemical species that react with surfactant molecules, i.e., O3 or its metabolites, are the same as or proportional to those chemical species responsible for initiating PMN inflammation. Additional experiments showed that lung tissue ascorbic acid concentration was significantly lower in pregnant and lactating rats than in virgin female rats. Although a causative relationship cannot be assumed, the deficit in tissue ascorbic acid concentration in pregnant and lactating rats compared with virgin female rats is consistent with their greater responsiveness and higher relative surfactant O3 dose. PMID- 9950897 TI - Proline in vasoactive peptides: consequences for peptide hydrolysis in the lung. AB - To examine the hypothesis that trans isomers of bradykinin and [Gly6]bradykinin are preferentially hydrolyzed by lung peptidases, we studied the fractional inactivation of these peptides in the perfused rat lung using a bioassay after a single-pass bolus injection and high-performance liquid chromatography after lung recirculation. In the bioassay studies, when the peptides passed through the lung, 25.6-fold more bradykinin or 7-fold more [Gly6]bradykinin was required to elicit a contraction equivalent to that produced when the peptides did not pass through the lung. In the recirculation studies, hydrolysis progress curves with rapid and slow phases were observed, with a higher fraction of bradykinin than [Gly6]bradykinin hydrolyzed in the rapid phase. Cyclophilin increased the hydrolysis rate during the slow phase for both peptides. Kinetic analysis indicated that the slowly hydrolyzed peptide fraction, presumably the cis fraction, was 0.13 for bradykinin and 0.43 for [Gly6]bradykinin with cis-trans isomerization rate constants of 0.074 and 0.049 s-1, respectively, consistent with published nuclear magnetic resonance studies. PMID- 9950898 TI - Effect of azelastine on platelet-activating factor-induced microvascular leakage in rat airways. AB - To determine the effect of the antiallergic drug azelastine on airway mucosal inflammation, we studied airway microvascular permeability in response to platelet-activating factor (PAF) in pathogen-free rats. Vascular permeability and neutrophil accumulation were assessed by the percent area occupied by Monastral blue-labeled blood vessels and by myeloperoxidase-containing granulocytes, respectively, in whole mounts of the trachea and main bronchus. Intravenous PAF caused dose-dependent increases in the area density of Monastral blue-labeled vessels and neutrophil influx, and the former effect was inhibited by depletion of circulating neutrophils by cyclophosphamide or treatment with the neutrophil elastase inhibitor ONO-5046. Pretreatment with azelastine inhibited PAF-induced vascular leakage without affecting neutrophil accumulation. This inhibitory effect of azelastine was not seen in neutropenic rats and ONO-5046-treated rats. PAF increased neutrophil elastase contents in bronchoalveolar lavage fluid, an effect that was inhibited by azelastine. Therefore, azelastine attenuates PAF induced airway mucosal microvascular leakage, probably involving inhibition of the release of neutrophil elastase from activated neutrophils. PMID- 9950899 TI - Chronic hypoxia augments endothelin-B receptor-mediated vasodilation in isolated perfused rat lungs. AB - To investigate whether chronic hypoxia affects endothelin-B (ETB) receptor mediated pulmonary vasodilation, we compared the vasodilator responses to IRL 1620, a selective ETB-receptor agonist, in isolated perfused lungs from normoxic and chronically hypoxic adult male rats. IRL-1620 caused a dose-dependent vasodilation that was greater in the hypertensive lungs than in the normotensive lungs. In normotensive lungs, a nitric oxide (NO) synthase inhibitor, Nomega nitro-L-arginine (L-NNA; 300 microM), and an ATP-sensitive potassium (KATP) channel inhibitor, glibenclamide (Glib; 10 microM), each reduced the vasodilator response to IRL-1620 (1 nM), but the combination of L-NNA and Glib inhibited it more effectively than either drug alone. In contrast, L-NNA alone, but not Glib alone, completely blocked IRL-1620-induced vasodilation in hypertensive lungs. The vasodilator response to a KATP-channel opener, NIP-121 (1 microM), but not the response to sodium nitroprusside (1 microM), was enhanced in hypertensive lungs. We also found increased expression of mRNA for the ETB receptor in lung tissue after hypoxic exposure. In addition, semiquantitative immunohistochemistry demonstrated higher expression levels of ETB receptors in the endothelium of distal segments of the pulmonary artery in hypoxic than in normoxic rats. These results suggest that ETB receptor-mediated pulmonary vasodilation is augmented after chronic hypoxic exposure and that release of NO may be the sole mechanism of this vasodilation in hypertensive lungs, whereas both release of NO and activation of KATP channels are involved in normotensive lungs. We speculate that the underlying mechanism responsible for this augmentation may partly be related to upregulation of ETB receptors in the endothelium of pulmonary resistance arteries in hypertensive lungs. PMID- 9950901 TI - Exocytosis in alveolar type II cells revealed by cell capacitance and fluorescence measurements. AB - Measurement of lamellar body (LB) exocytosis at high spatial and temporal resolution was recently enabled by fluorescence of the dye FM 1-43 (FFM1-43). Here, the capabilities of this method were further examined and extended by simultaneous measurement of the cell membrane capacitance (Cm) and laser-scanning confocal microscopy. Step increases in Cm were evoked by extracellular ATP (20 microM) or an elevated pipette Ca2+ concentration (>/=3 microM). The delay between the first Cm step and the increase in FFM1-43 was <1 s, indicating ready access of FM 1-43 to exocytosed LB contents. A specific Cm of 0.88 microF/cm2 for the membrane of an exocytosed LB was calculated. Compound exocytosis was occasionally observed. Decreases in Cm, indicative of transient fusion or endocytosis, did not occur within 20 min of stimulation. Exocytosis was stimulated by 160 microM guanosine 5'-O-(3-thiotriphosphate) in the pipette, but compound exocytosis was unaffected. The comparison of methods revealed that FM 1 43 is ideally suited to measure the onset of exocytosis and amount of secretion. Patch clamp is superior in resolving fusion events with the plasma membrane. PMID- 9950900 TI - EMAP II: a modulator of neovascularization in the developing lung. AB - Neovascularization is a key regulatory process in fetal growth and development. Although factors promoting growth and development of the pulmonary vasculature have been investigated, nothing is known regarding the molecular mechanisms that may counteract these stimuli. Endothelial monocyte-activating polypeptide (EMAP) II has recently been identified as an antiangiogenic factor in tumor vascular development. We postulated that EMAP II is a putative negative modulator of lung vascular growth. EMAP II mRNA and protein decrease fivefold (P < 0.01) as the developing lungs in the fetal mouse progress from having poor vascularization (day 14) to having complete vascular development at term (day 18.5). EMAP II protein expression continues to remain low throughout postnatal life and into adulthood, with the exception of a surge that correlates with microvascular maturation. Furthermore, through the use of in situ hybridization and immunohistochemistry, EMAP II is localized throughout the lung, with significant expression in the submyoepithelial area during the early stages of lung development when there is minimal vascular development. In contrast, EMAP II is distributed around the large vessels during the end of vascular development, suggesting that EMAP II modulates the neovascularization process. We speculate that EMAP II is a director of neovascularization in the developing lung. PMID- 9950902 TI - Nitric oxide synthase isoform expression in the developing lung epithelium. AB - Nitric oxide (NO), generated by NO synthase (NOS), is an important mediator of physiological processes in the airway and lung parenchyma, and there is evidence that the pulmonary expression of the endothelial isoform of NOS (eNOS) is developmentally regulated. The purpose of the present study was to delineate the cellular distribution of expression of eNOS in the developing respiratory epithelium and to compare it with inducible (iNOS) and neuronal (nNOS) NOS. Immunohistochemistry was performed on fetal (125-135 days gestation, term 144 days), newborn (2-4 wk), and maternal sheep lungs. In fetal lung, eNOS expression was evident in bronchial and proximal bronchiolar epithelia but was absent in terminal and respiratory bronchioles and alveolar epithelium. Similar to eNOS, iNOS was detected in bronchial and proximal bronchiolar epithelia but not in alveolar epithelium. However, iNOS was also detected in terminal and respiratory bronchioles. nNOS was found in epithelium at all levels including the alveolar wall. iNOS and nNOS were also detected in airway and vascular smooth muscle. The cellular distribution of all three isoforms was similar in fetal, newborn, and adult lungs. Findings in the epithelium were confirmed by isoform-specific reverse transcription-polymerase chain reaction assays and NADPH diaphorase histochemistry. Thus the three NOS isoforms are commonly expressed in proximal lung epithelium and are differentially expressed in distal lung epithelium. All three isoforms may be important sources of epithelium-derived NO throughout lung development. PMID- 9950903 TI - Antenatal steroids decrease blood-brain barrier permeability in the ovine fetus. AB - Antenatal corticosteroid therapy reduces the incidence of intraventricular hemorrhage in premature infants. Enhanced microvascular integrity might provide protection against intraventricular hemorrhage. In the adult, there is evidence to suggest that the blood-brain barrier may be under hormonal control. We hypothesized that antenatal corticosteroids decrease blood-brain barrier permeability in the preterm ovine fetus. Chronically instrumented 120-day gestation fetuses were studied 12 h after the last of four 6-mg dexamethasone (n = 5) or placebo (n = 6) injections had been given over 48 h to the ewes. Blood brain barrier function was quantified with the blood-to-brain transfer constant (Ki) for alpha-aminoisobutyric acid (AIB). Ki was significantly lower across brain regions in the fetuses of ewes that received antenatal dexamethasone compared with placebo (ANOVA; interaction, F = 2.54, P < 0.004). In fetuses of dexamethasone- and placebo-treated ewes, Ki (microliter . g brain wt-1. min-1, mean +/- SD) was, respectively, 2.43 +/- 0.27 vs. 3.41 +/- 0.74 in the cortex, 4.46 +/- 0.49 vs. 5.29 +/- 0.85 in the cerebellum, and 3.70 +/- 0.49 vs. 5.11 +/- 0.70 in the medulla. We conclude that antenatal treatment with corticosteroids reduces blood-brain permeability in the ovine fetus. PMID- 9950904 TI - GABA-mediated inhibition of raphe pallidus neurons regulates sympathetic outflow to brown adipose tissue. AB - Sympathetic nerve activity to brown adipose tissue (BAT) regulates adipocyte metabolism of its stored lipid fuel and thus the thermogenesis in BAT. To determine if the discharge of neurons in the rostral raphe pallidus (RPa) can influence BAT thermogenesis, changes in sympathetic nerve activity to BAT were recorded after microinjection (60 nl) of the GABAA receptor antagonist bicuculline (500 microM) into the RPa in chloralose-urethan-anesthetized, ventilated rats. Bicuculline caused a large, rapid rise in the sympathetic nerve activity to BAT (which had also increased during acute hypothermia) from very low, normothermic control levels to maximum values (mean: 1,949 +/- 604% control; n = 13) after 4-6 min. The sympathetic nerve discharge to BAT had a mean burst frequency (3. 5 +/- 0.3 Hz) that was significantly less than the heart rate (7.3 +/- 0.2 beats/min), and it was not inhibited during baroreceptor reflex activation. Bicuculline-stimulated increases in the sympathetic nerve activity to BAT and cold-evoked increases in neuronal fos expression were localized to the RPa at the level of the caudal half of the facial nucleus. This dramatic increase in sympathetic nerve activity to BAT after disinhibition of neurons in rostral RPa is consistent with a major role for RPa neurons, perhaps as sympathetic premotoneurons for BAT, in medullary control of BAT thermogenesis. PMID- 9950905 TI - Light masking of circadian rhythms of heat production, heat loss, and body temperature in squirrel monkeys. AB - Whole body heat production (HP) and heat loss (HL) were examined to determine their relative contributions to light masking of the circadian rhythm in body temperature (Tb). Squirrel monkey metabolism (n = 6) was monitored by both indirect and direct calorimetry, with telemetered measurement of body temperature and activity. Feeding was also measured. Responses to an entraining light-dark (LD) cycle (LD 12:12) and a masking LD cycle (LD 2:2) were compared. HP and HL contributed to both the daily rhythm and the masking changes in Tb. All variables showed phase-dependent masking responses. Masking transients at L or D transitions were generally greater during subjective day; however, L masking resulted in sustained elevation of Tb, HP, and HL during subjective night. Parallel, apparently compensatory, changes of HL and HP suggest action by both the circadian timing system and light masking on Tb set point. Furthermore, transient HL increases during subjective night suggest that gain change may supplement set point regulation of Tb. PMID- 9950906 TI - Upregulation of M-creatine kinase and glyceraldehyde3-phosphate dehydrogenase: two markers of muscle disuse. AB - Muscle disuse induces substantial alterations in the highly plastic skeletal muscle tissues, which occur especially in antigravity slow muscles. We differentially screened a muscle cDNA array to identify modifications in gene profile expression induced in slow rat soleus muscle mechanically unloaded by hindlimb suspension as a model for muscle disuse. This study focused on muscle creatine kinase mRNA and protein and glyceraldehyde-3-phosphate dehydrogenase mRNA, which were found to be upregulated in unweighted muscles. These upregulations were analyzed over a 4-wk time course of hindlimb suspension and compared with variations in myosin heavy chain (MHC) isoforms while specifically focusing on type IIx MHC mRNA and protein. The two metabolic marker upregulations clearly preceded IIx MHC contractile protein upregulation. Muscle creatine kinase upregulation was shown to be an excellent, and the earliest, marker of muscle disuse at mRNA and protein levels. PMID- 9950907 TI - Chronic hypercapnia resets CO2 sensitivity of avian intrapulmonary chemoreceptors. AB - Avian intrapulmonary chemoreceptors (IPC) are vagal sensory neurons that participate in the control of breathing. IPC action potential frequency is inversely proportional to PCO2, but it is unclear whether low PCO2 or high pH is the immediate stimulus for signal transduction in IPC. To address this question, comparisons were made between single cell neural responses of 34 IPC recorded in 6 anesthetized ducks (Anas platyrhynchos) acclimatized 12 days to 7.5% inspired CO2 and 22 IPC recorded in 9 normal anesthetized ducks. We hypothesized that if respiratory-linked pH changes determine IPC activity, action potential frequency as a function of inspiratory PCO2 (PICO2) should be greater after acclimatization due to metabolic acid-base compensation and higher pH. Conversely, if PCO2 alone determines IPC discharge, action potential frequency vs. PCO2 should be unchanged by acclimatization. Results indicate that after acclimatization ventilation was depressed at 28 and 42 Torr PICO2 (P < 0.05) and mean plasma pH at 40 Torr PCO2 increased from 7.38 +/- 0. 03 to 7.56 +/- 0.02 (P < 0.05), indicating significant metabolic acid-base compensation and HCO-3 retention. Mean IPC discharge rate was elevated by CO2 acclimatization at all PCO2 studied. In acclimatized vs. normal animals, regression analysis of IPC discharge as a function of lnPCO2 showed increased mean intercepts of 81.1 +/- 4.0 vs. 48.4 +/- 3.6 impulses/s (P < 0.05) and increased mean slopes of -19.0 +/- 1.0 vs. -12.0 +/- 1.1 impulses. s-1. lnPCO2-1 (P < 0.05). Results indicate that IPC response to CO2 is mediated by H+ from CO2 hydration and not by CO2 directly. PMID- 9950909 TI - Excitation-induced Ca2+ uptake in rat skeletal muscle. AB - In isolated rat extensor digitorum longus (EDL) muscle mounted for isometric contractions, chronic low-frequency electrical stimulation was found to lead to an increased uptake of 45Ca (154% above control after 240 min) and a progressive accumulation of Ca2+ (85% above control after 240 min). In soleus, however, this treatment led to a small, but significant, increase in 45Ca uptake (30% above control after 180 min) but no significant accumulation of Ca2+. In muscles mounted for isotonic contractions without any external load, electrical stimulation gave rise to a larger 45Ca uptake and accumulation of Ca2+ in both EDL and soleus. These uptakes of Ca2+ coincided with an accumulation of Na+. During isometric or isotonic contractions, stimulation at 40 Hz increased the initial (60 s) rate of 45Ca uptake in soleus muscle 15- and 30-fold, respectively. The stimulation-induced increase in 45Ca uptake was only reduced by 17% by the Ca2+-channel blockers nifedipine and verapamil but was blocked by tetrodotoxin. The initial rate of stimulation-induced 22Na and 45Ca uptake was correlated (r = 0.80; P < 0.003). Stimulation of Na+ channels with veratridine increased 45Ca uptake by 93 and 139% in soleus and EDL, respectively (P < 0.001), effects that were abolished by tetrodotoxin. The results indicate that in skeletal muscle, excitation induces a considerable influx of Ca2+, mediated by Na+ channels. PMID- 9950908 TI - CCK-A receptor antagonists have selective effects on nutrient-induced food intake suppression in rats. AB - To provide additional support to the hypothesis that only dietary protein (Pro; chicken egg albumin) and not amino acids (AA; patterned after albumin), carbohydrates (CHO; cornstarch), or fats (Fat; corn oil) produces a satiating effect via CCK receptors, two CCK-A receptor antagonists (PD-140,548 and devazepide) were coadministered with each nutrient. Given alone [4 ml intragastrically (ig)] Pro (1.0 g), AA (1.0 g), CHO (1.4 g), and Fat (2.4 g) suppressed (P < 0.05) food intake on average during the first 2 h of feeding by 1.4 (36%), 1.5 (48%), 1.0 (33%), and 1.2 g (41%), respectively. Devazepide (0.5 mg/kg) and PD-140,548 (1.0 mg/kg) given alone increased food intake during 0-2 h by 0.7 g (18%) and during 0-1 h by 0.5 g (15%), respectively. When coadministered with PD-140,548 (1.0 mg/kg ip), the suppression of food intake caused by Pro was modulated during 0-2 h by 57% (Pro x drug interaction, P < 0.05), but AA-, CHO-, and Fat-induced suppression of feeding was not affected (nutrient x drug interaction, P > 0.05). Devazepide (0.5 mg/kg ip) did not modulate AA-, CHO-, and Fat-induced food intake suppression during any time period (nutrient x drug interaction, P > 0.05). These studies provide additional evidence that CCK-A receptors play a role in Pro (albumin) but not AA-, CHO (cornstarch)-, or Fat (corn oil)-induced food intake suppression in rats. PMID- 9950910 TI - Altered fetal cardiovascular responses to prolonged hypoxia after sinoaortic denervation. AB - This study examines the role of the peripheral chemoreceptors in mediating fetal cardiovascular responses to prolonged hypoxia secondary to reduced uterine blood flow (RUBF). Fetal sheep were chronically instrumented for continuous heart rate (FHR), blood pressure (FBP), and carotid blood flow (CBF) measurements after bilateral sectioning of the carotid sinus and vagus nerves (denervated, n = 7) or sham denervation (intact, n = 7). Four days postoperatively, uterine blood flow was mechanically restricted, reducing fetal arterial oxygen saturation by 47.3% (P < 0.01). An initial bradycardia was observed in intact (184.0 +/- 10.7 to 160.5 +/- 10.7 beats/min, not significant) but not denervated fetuses, followed by a tachycardia (180.0 +/- 2.2 to 193.7 +/- 2.7 beats/min, P < 0.05). FHR increased in denervated fetuses (175.5 +/- 8.7 to 203. 0 +/- 17.9 beats/min, P < 0.05). FBP increased transiently in intact fetuses from 45.1 +/- 1.0 to 55.4 +/- 3.0 mmHg at 2 h (P < 0.01), whereas denervated fetuses demonstrated a decrease in FBP from 47.1 +/- 4.2 to 37.2 +/- 3.7 mmHg (not significant). CBF increased (P < 0. 05) in both intact and denervated fetuses from 39.3 +/- 2.8 and 29.7 +/- 3.8 ml. min-1. kg-1 to 47.7 +/- 0.4 and 39.1 +/- 0.3 ml. min-1. kg-1, respectively, whereas carotid vascular resistance decreased only in denervated fetuses (1.7 +/- 0.1 to 1.1 +/- 0.02 mmHg. ml-1. min. kg-1, P < 0.05). We conclude that the peripheral chemoreceptors play an important role in mediating fetal cardiovascular responses to prolonged RUBF. PMID- 9950911 TI - Oxygen binding and its allosteric control in hemoglobin of the pulmonate snail, Biomphalaria glabrata. AB - Pulmonate snails that experience extreme variations in gas tensions and temperatures possess extracellular, high-molecular mass ( approximately 1.7 x 10(6) Da) hemoglobins (Hbs) that are little known as regards oxygenation and allosteric characteristics. Biomphalaria glabrata hemolymph exhibits a high O2 affinity (half-saturation O2 tension = 6.1 mmHg; pH 7.7, 25 degreesC), pronounced Bohr effect (Bohr factor = -0.5), and pH-dependent cooperativity (Hill's cooperativity coefficient at half-saturation = 1.1-2.0). Divalent cations increase O2 affinity, Ca2+ exerting greater effect than Mg2+. Analyses in terms of the Monod-Wyman-Changeux model indicate novel O2 affinity control mechanisms. In contrast to vertebrate Hb, where organic phosphates and protons lower affinity via decreased O2 association equilibrium constant of Hb in low-affinity state (KT), and to extracellular annelid Hbs, where protons and cations primarily modulate O2 association equilibrium constant of Hb in high-affinity state (KR), in B. glabrata Hb, the Bohr effect is mediated predominantly via KR and the cation effect via KT, reflecting preferential, oxygenation-linked proton binding to oxygenated Hb and cation binding to deoxygenated Hb. CO2 has no specific (pH independent) effect. Nonlinear van't Hoff plots show temperature dependence of the overall heats of oxygenation, indicating oxy-deoxy heat capacity differences. The findings are related to possible physiological significance in pond habitats. PMID- 9950912 TI - Neutralization of TNF does not influence endotoxininduced changes in thyroid hormone metabolism in humans. AB - To determine the role of tumor necrosis factor (TNF) in endotoxin-induced changes in plasma thyroid hormone and thyroid-stimulating hormone (TSH) concentrations, 24 healthy postabsorptive humans were studied on a control study day (n = 6), after infusion of a recombinant TNF receptor IgG fusion protein (TNFR:Fc; 6 mg/m2; n = 6) after intravenous injection of endotoxin (2 ng/kg; n = 6), or after administration of endotoxin with TNFR:Fc (n = 6). Administration of TNFR:Fc alone did not affect thyroid hormone or TSH levels when compared with the control day. Endotoxin induced a transient rise in plasma TNF activity (1.5 h: 219 +/- 42 pg/ml), which was completely prevented by TNFR:Fc (P < 0.05). After endotoxin administration, plasma L-thyroxine (T4), free T4, 3,5, 3'-triiodothyronine (T3), and TSH were lower and 3,3', 5'-triiodothyronine was higher than on the control day (all P < 0. 05). Coinfusion of TNFR:Fc with endotoxin did not influence these endotoxin-induced changes. Our results suggest that endogenous TNF does not play an important role in the alterations in plasma thyroid hormone and TSH concentrations induced by mild endotoxemia in healthy humans. PMID- 9950914 TI - Effect of diet on the response to leptin in the marsupial Sminthopsis crassicaudata. AB - The aim of this study was to determine in the marsupial Sminthopsis crassicaudata 1) the effect of leptin on food intake, body fat stores, and metabolism and 2) whether leptin can prevent a diet-induced increase in adiposity. In response to 21 days of feeding with mealworms (2.99 kcal/g, 30% fat), body weight (P < 0. 0001) and tail width (P < 0.0001) increased, compared with control animals fed with laboratory diet (1.01 kcal/g, 20% fat). Subsequently, S. crassicaudata were randomly allocated to receive either laboratory diet or a choice between laboratory diet and mealworms. For 13 days, one-half of the animals in each dietary group received intraperitoneal human leptin (2.5 mg/kg twice daily), while the other one-half received phosphate-buffered saline. In animals receiving laboratory diet alone, leptin induced a decrease in body weight (P < 0.0001), tail width (P < 0.0001), and energy intake (P < 0.01). In animals receiving both laboratory diet and mealworms, leptin had no effect on body weight or tail width, although the proportion of laboratory diet eaten was reduced (P = 0. 0001), and there was a nonsignificant fall in overall energy intake (P = 0.07). We conclude that in S. crassicaudata, 1) a high-calorie, higher-fat diet induces an increase in adiposity and 2) leptin induces weight loss, but 3) an increase in dietary calories and fat content is associated with resistance to the actions of leptin. PMID- 9950913 TI - Isolation of viable cell types from the gill epithelium of Japanese eel Anguilla japonica. AB - High-purity viable cells with low mitochondria (pavement cells) and mitochondria rich content (chloride cells) were successfully isolated from the gill epithelium of Japanese eels, using three-step Percoll gradient low-speed centrifugation. Cytochemistry (silver staining for chloride, rhodamine-123, and Mitotracker for mitochondria and actin/spectrin immunofluorescence) and scanning electron microscope images were used to identify the cell types in the gill epithelium of the eel. Pavement cells were isolated at 97 and 98% purity for freshwater- and seawater-adapted eels, respectively, and chloride cells were obtained at 89 and 92% purity. The enzymatic activities of the isolated cells were determined. Na+ K+-ATPase, Mg2+-ATPase, and succinate dehydrogenase were found mainly in the chloride cell. Alkaline Ca2+-ATPase and low- and high-affinity Ca2+-ATPase were about twice as high in the chloride cell compared with the pavement cell. Transfer of eels to seawater resulted in enlargement of chloride cell sizes and significant increases in Na+-K+-ATPase, Mg2+-ATPase, and succinate dehydrogenase activities, while all Ca2+-ATPases declined by approximately 60-80%. This is the first report demonstrating the successful isolation of freshwater chloride cells and also an exclusive method of getting high-purity seawater chloride cells. The isolated cells are viable and suitable for further cytological and molecular studies to elucidate the mechanisms of ionic transport. PMID- 9950915 TI - Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats. AB - The neuropeptide Y (NPY) neurons in the hypothalamic arcuate nucleus regulate and are regulated by short-term changes in energy homeostasis. Both outbred and inbred strains of rats that develop diet-induced obesity (DIO) or are diet resistant (DR) when fed a diet relatively high in energy, fat, and sucrose content (HE diet) were used to study arcuate NPY mRNA expression during long-term changes in energy balance. Outbred, chow-fed obesity-prone rats had 59% higher NPY levels than obesity-resistant rats. After 14 wk on HE diet, DIO rats had 17% lower NPY levels than DR rats made comparably obese on a highly palatable diet. When switched to chow, obese DR rats spontaneously reduced their intake and their body weights fell to control levels in association with a 10% decrease in NPY levels. DIO rats lost weight only with energy restriction associated with a 21% increase in their NPY levels. When again fed ad libitum, the weight and NPY levels in the rats returned to those of unrestricted DIO rats. Chow-fed, inbred DIO rats weigh more and are fatter than age-matched inbred DR rats. As with outbred DIO rats fed the HE diet, inbred DIO rats had 20% lower NPY levels than DR rats. Thus preobese, outbred DIO rats have high levels of NPY message that are not susceptible to metabolic regulation. When obesity develops in both inbred and outbred rats, the levels of NPY mRNA fall but become responsive to alterations in energy availability. PMID- 9950916 TI - Electrophysiological and behavioral studies on taste effectiveness of alcohols in rats. AB - Electrophysiological and behavioral studies were performed in rats to analyze the gustatory effects of alcohols, such as methanol, ethanol, ethylene glycol, 1 propanol, 2-propanol, propylene glycol, 1,3-propandiol, and glycerin. When the whole bundle responses to each of the alcohols at 1.0 M were recorded from the chorda tympani (CT) and glossopharyngeal nerve (Gl), the alcohols with two or three hydroxyl groups elicited larger responses than the other alcohols in both nerves. Single-fiber analyses showed that the responses to alcohols were induced dominantly in sucrose-best fibers and were correlated well with sucrose responses in the CT, whereas the responses to alcohols were induced in quinine-best fibers and were correlated well with quinine responses in the Gl. The rats that acquired conditioned taste aversions to alcohols with two or three hydroxyl groups also avoided sucrose and quinine, although the aversion did not generalize to NaCl or HCl. These results suggest that alcohols have a taste similar to the taste of both sucrose and quinine in the rat. PMID- 9950917 TI - Effects of urea and trimethylamine N-oxide on fluidity of liposomes and membranes of an elasmobranch. AB - The effects on membrane fluidity of two solutes of biological importance in elasmobranch fishes, urea and trimethylamine oxide (TMAO), were determined using elasmobranch red blood cell plasma membranes and artificial liposomes. Fluorescence polarizations of three probes with differing sites of insertion (1, 6-diphenylhexatriene, cis-parinaric acid, and trans-parinaric acid) were used to study the effects of physiological levels of urea (400 mM) and TMAO (200 mM) separately and together in a 2:1 urea:TMAO ratio (400 mM:200 mM). In the elasmobranch erythrocyte membrane, there was a trend toward an increase in the order of the gel-phase domains when treated with urea, although this was not statistically significant. This effect was counteracted by the presence of TMAO. To determine if the organic solutes were acting directly on the membrane lipids or on the integral proteins, phase-transition profiles of protein-free dipalmitoyl phosphatidylcholine liposomes were determined. These profiles showed that urea again increased the order of the gel-phase domains of the bilayer; however, this effect was not counteracted by the presence of TMAO. We suggest that the increased order in the gel-phase domains may be an indirect effect of a decrease in the order of the fluid-phase domains. This increase in fluidity may be due either to a disruptive effect of urea on the hydrophobic core of the membrane or to indirect effects mediated by changes in the integral membrane proteins. This study is the first to demonstrate that urea and TMAO may act as counteracting solutes in the elasmobranch erythrocyte membrane and that the counteraction appears to be at the level of the integral proteins rather than the membrane lipids. PMID- 9950918 TI - Sex differences and role of nitric oxide in blood flow of canine urinary bladder. AB - Continuous measurements were made of bladder blood flow by laser Doppler flowmetry in anesthetized dogs during bladder filling and emptying. In both mucosa and muscle, perfusion was inversely proportional to intravesical pressure. There was significantly greater perfusion in the bladder mucosa of males than females at baseline and up to 10 cm water filling pressure but not in the muscle. Intra-arterial infusion of the nitric oxide synthase inhibitor NG-nitro-L arginine produced a significant decrease in resting bladder perfusion in the mucosa only, with no differences seen in the response to intravesical pressure. Intra-arterial infusion of L-arginine produced a significant increase in the level of perfusion in the mucosa seen immediately after the bladder was drained. No changes were observed in muscle perfusion after L-arginine. These results suggest that the perfusion of the bladder mucosa differs by gender and is regulated differently than the bladder muscle, possibly related to the different function of the two layers. PMID- 9950919 TI - Effect of endurance exercise on myosin heavy chain gene regulation in human skeletal muscle. AB - The purpose of this study was to determine the effect of endurance-oriented exercise on myosin heavy chain (MHC) isoform regulation in human skeletal muscle. Exercise consisted of 1 h of cycle ergometer work per day at 75% maximal oxygen consumption for seven consecutive days. Muscle was obtained before the first bout of exercise, 3 h after the first bout of exercise, and before and 3 h after the final exercise bout on day 7 (n = 9 subjects). No changes in MHC mRNA (I, IIa, IIx) were evident after the first exercise period. There was, however, a significant (P < 0.05) decline (-30%) in MHC IIx mRNA 3 h after the final training bout. An interesting finding was that a higher pretraining level of MHC IIx mRNA was associated with a greater decline in the transcript before (r = 0.68, P < 0.05) and 3 h after (r = 0.82, P < 0.05) the final exercise bout. These findings suggest that MHC IIx mRNA is downregulated during the early phase of endurance-oriented exercise training in human skeletal muscle but only after repeated contractile activity. Pretraining MHC IIx mRNA content may influence the magnitude of this response. PMID- 9950920 TI - GABA receptors in the phrenic nucleus of the rat. AB - The phrenic nucleus was identified by microinjections of N-methyl-D-aspartic acid in urethan-anesthetized adult male Wistar rats. Microinjections of GABAA and GABAB receptor agonists (muscimol and baclofen, respectively) at the same site decreased the phrenic nerve burst amplitude. Microinjections of GABAA and GABAB receptor antagonists (bicuculline and 2-hydroxysaclofen, respectively) blocked as well as reversed the effects of their respective agonists. These results were confirmed by recording extracellular action potentials from single phrenic neurons. Micropressure applications of muscimol and baclofen decreased the activity of single neurons in the phrenic nucleus; this effect was blocked as well as reversed by micropressure applications of bicuculline and 2 hydroxysaclofen, respectively. These results demonstrated the presence of GABA receptors on the neurons in the phrenic nucleus and suggested that their activation results in the decrease of the phrenic nerve burst amplitude. The importance of these results in the identification of neural circuits mediating inhibition of phrenic neurons is discussed. PMID- 9950921 TI - Cholecystokinin and serotonin receptors in the regulation of fat-induced satiety in rats. AB - The present study investigated the relationship between endogenous CCK and serotonin (5-HT) in fat-induced satiety. Male Wistar rats with duodenal cannulas were adapted to eating 6 h/day along with receiving an infusion of saline or one of two isocaloric solutions (10 ml, 1 kcal/ml, 0.45 ml/min) varying in fat and carbohydrate content (20 or 80% energy from fat). Rats were infused 10 min after food presentation. The satiation/satiety response was determined from measures of meal size (MS), intermeal interval (IMI), and total food intake (TFI). Infusion with either fat solution reduced MS compared with saline; however, the 80% fat infusate reduced TFI and lengthened the IMI compared with saline and the 20% fat infusate. CCK and 5-HT involvement in fat-induced satiety was investigated by preceding the 80% fat infusate with CCK and/or 5-HT3 receptor antagonists Devazepide (Dev) and Tropisetron (Trop). A CCK releaser, trypsin inhibitor (TI), was added to the 20% fat infusate to enhance satiety. Pretreatment with Dev or Trop alone attenuated the inhibitory effects of the 80% solution on IMI, whereas reversal of the inhibitory effects on MS and TFI were sensitive only to Dev at the doses provided. Both antagonists together completely blocked the satiating effects of the 80% fat infusate on all feeding variables measured. Addition of TI to the 20% fat infusate lengthened the IMI but did not affect MS or TFI. These results provide evidence for the participation of both endogenous CCK and 5-HT in the satiety response to fat in the intestine. PMID- 9950922 TI - Effect of behavioral stress on coronary artery relaxation altered with aging in BHR. AB - Behavioral stress and aging are associated with an increase in vascular disease. This study determined the mechanisms contributing to changes in endothelium dependent relaxation of isolated coronary arteries (300-350 micrometers) induced by exposure to 10 days of air-jet stress (2 h/day) in young (3 mo) and old (18 mo) male borderline hypertensive rats (BHR). Aging, alone, did not alter endothelium-dependent relaxation to acetylcholine (ACh) quantitatively but did alter the mechanisms contributing to relaxation to ACh, which was largely dependent on nitric oxide synthase (NOS) in vessels from old, but not young, BHR. Behavioral stress resulted in an enhanced relaxation to ACh that was dependent on NOS in vessels from young stressed compared with young control BHR. Conversely, relaxation to ACh was reduced in coronary arteries from old stressed compared with old control BHR. In vessels from old control BHR, there was an NOS independent component of relaxation mediated by opening of K+ channels that was absent in vessels from old stressed BHR. The superoxide anion scavenger, tiron, partially restored relaxation, and inhibition of cyclooxygenase largely restored relaxation to ACh in vessels from old stressed BHR. In summary, the effect of behavioral stress was age dependent. ACh-induced relaxation of coronary arteries was enhanced in an NOS-dependent manner in young BHR and was impaired in old BHR due to superoxide anions, vasoconstrictor cyclooxygenase products, and a loss of K+ channel-mediated relaxation. PMID- 9950923 TI - Intracavernous pressure during erection in rats: an integrative approach based on telemetric recording. AB - To better understand the similarities and differences in the neural control of penile erection occurring in different contexts, we recorded intracavernous pressure (ICP) in conscious rats using a miniaturized telemetric device. ICP changes during reflexive, noncontact, and apomorphine-induced erections were characterized by a plateau increase surmounted by peaks. Plateaus were also elicited by cavernous nerve stimulation in anesthetized rats, suggesting that the cavernous nerve represents the final common proerectile autonomic pathway in these contexts and that it responds similarly to information originating in the periphery or in supraspinal nuclei. During reflexive, noncontact, and apomorphine induced erections, activation of spinal autonomic nuclei, considered the spinal generators of erection, would take place first, representing a prerequisite for the occurrence of peaks. Suprasystolic peaks would result from the addition of pudendal motoneuron activity. In contrast, only peaks were recorded during copulation. In this context, the convergence of peripheral and supraspinal information apparently elicits the best temporal arrangement of autonomic and somatic outflows, reflecting a highly organized and integrated spinal activity. PMID- 9950924 TI - Arginine vasopressin does not mediate the attenuated febrile response to intravenous IL-1beta in pregnant rats. AB - Rats have an attenuated febrile response to intravenous endogenous pyrogen [e.g., interleukin-1beta (IL-1beta)] near the term of pregnancy. The present experiments were carried out on 25 nonpregnant and 32 pregnant rats to test the hypothesis that arginine vasopressin functioning as an endogenous antipyretic substance in the central nervous system mediates this attenuated febrile response. An intravenous injection of recombinant rat IL-1beta (rrIL-1beta) after intracerebroventricular vehicle produced a significant increase in core temperature in both nonpregnant and pregnant animals, the magnitude and duration of which was greater in the nonpregnant rats. In nonpregnant rats, intravenous rrIL-1beta after intracerebroventricular vasopressin V1-receptor antagonist accentuated the core temperature response compared with that observed with intravenous rrIL-1beta after intracerebroventricular vehicle. In pregnant animals, however, intravenous rrIL-1beta after intracerebroventricular vasopressin V1-receptor antagonist produced a decrease in core temperature rather than an increase in core temperature, which was observed with intravenous rrIL 1beta after intracerebroventricular vehicle. Thus our data do not support the hypothesis that a pregnancy-related activation of arginine vasopressin as an endogenous antipyretic substance in the central nervous system attenuates the febrile response to intravenous rrIL-1beta near the term of pregnancy in rats. PMID- 9950925 TI - Extrinsic inputs to intrinsic neurons in the porcine heart in vitro. AB - Convergence of inputs from extrinsic cardiac nerves [vagus and cardiopulmonary (CPN)] on intrinsic cardiac neurons was investigated in the pig (Sus scrofa). A segment of the right atrial wall containing epicardial neurons along with attached stumps of the right vagus nerve and CPN was maintained in vitro; intracellular recordings were made from 57 neurons. Three types of neuron were identified by their responses to long intracellular depolarizing current pulses: phasic [discharged 1 action potential (AP); 40%]; accommodating (discharged multiple APs decrementing in frequency during pulse; 33%); and tonic (discharged multiple APs at a high frequency; 27%). Sixty-six percent of the neurons responded with excitatory postsynaptic potentials (EPSP) to vagal nerve stimulation; two-thirds of these cells fired APs when EPSP amplitude exceeded threshold level. Postsynaptic responses to vagal nerve stimulation were mediated by nicotinic ion channels; responses were eliminated by hexamethonium. CPN stimulation produced EPSPs but no APs in 17% of the neurons. All neurons responding with postsynaptic depolarizations to CPN stimulation also received vagal inputs. Combined stimulation of the vagus nerve and CPN produced APs in all but one of these neurons. Timolol eliminated postsynaptic responses from CPN stimulation, indicating that these responses involved beta-adrenergic receptors and likely resulted from activation of sympathetic postganglionic terminals. These results show that some intrinsic cardiac neurons receive convergent inputs from the CPN and vagus nerve. It is suggested that such neurons represent intraganglionic sites for sympathetic-parasympathetic interactions in neural control of the heart. PMID- 9950927 TI - Centrally mediated effect of 17beta-estradiol on parasympathetic tone in male rats. AB - The following experiments were conducted to determine if peripherally administered estrogen has an effect on central autonomic tone and whether this change in tone results in an alteration in cardiovascular reflex control. Male Sprague-Dawley rats were anesthetized with thiobutabarbitol sodium (50 mg/kg) and instrumented to record blood pressure, heart rate, and vagal parasympathetic or renal sympathetic efferent nerve activity. Additional rats were instrumented to test the sensitivity of the cardiac baroreflex using intravenous injections of phenylephrine hydrochloride (0.025, 0.05, 0.1 mg/kg) or sodium nitroprusside (0. 0025, 0.005, 0.01 mg/kg) and plotting the cardiovascular responses. Intravenous injection of estrogen (10(-4), 10(-2), and 10(-1) mg/kg) produced a significant increase in vagal efferent activity and in baroreflex sensitivity. The bilateral microinjection of an estrogen receptor antagonist, ICI-182,780 (1 pM, 50 nl/side) into the nucleus ambiguus blocked both the estrogen-induced increase in vagal efferent activity and baroreflex sensitivity. These results demonstrate that in male rats estrogen acts centrally to enhance baroreflex sensitivity by increasing parasympathetic efferent tone. PMID- 9950926 TI - Sepsis is associated with increased ubiquitinconjugating enzyme E214k mRNA in skeletal muscle. AB - Previous studies provided evidence that sepsis is associated with increased ubiquitin-proteasome-dependent protein breakdown in skeletal muscle. The 14-kDa ubiquitin-conjugating enzyme (E214k) has been proposed to be a key regulator of the ubiquitin proteolytic pathway. We tested the hypothesis that E214k message and protein levels are increased in skeletal muscle during sepsis. Sepsis was induced in rats by cecal ligation and puncture (CLP). Control rats were sham operated. E214k mRNA and protein levels were quantitated after Northern and Western blot analysis, respectively, 16 h after CLP or sham operation. Sepsis resulted in a 70% increase in the 1. 2-kb E214k transcript in the fast-twitch extensor digitorum longus muscle, whereas no changes were seen in the slow-twitch soleus muscle. E214k protein levels were not influenced by sepsis in any of the muscles studied. Although the changes in the expression of the E214k 1.2-kb transcript paralleled the differential effect of sepsis on protein breakdown in fast- and slow-twitch muscle, the potential role of E214k in the regulation of sepsis-induced muscle proteolysis needs to be interpreted with caution, because the results demonstrated that increased message levels were not associated with increased E214k protein levels. PMID- 9950929 TI - Na+-K+-ATPase and Na+/Ca2+ exchange activities in gills of hyperregulating Carcinus maenas. AB - Na+-K+-ATPase and Na+/Ca2+ exchange activities were studied in gills of Carcinus maenas in seawater (SW) and after transfer to dilute seawater (DSW). Carcinus hyperregulates its hemolymph osmolarity through active uptake of Na+, Cl-, and Ca2+. In DSW total Na+-K+-ATPase activity in posterior gills quadrupled; Na+/Ca2+ exchange specific activity was unaffected, and total activity increased 1.67 fold. Short-circuit current (Isc) in voltage-clamped posterior gill hemilamellae was -181 microA/cm2 in SW and -290 microA/cm2 in DSW and up to 90% ouabain sensitive; conductivity was similar in SW or DSW (42 and 46 mS/cm2, respectively) and representative of a leaky epithelium. The new steady state of hemolymph osmolarity 24 h after DSW transfer was preceded, already 3 h after transfer, by increased Na+-K+-ATPase but not Na+/Ca2+ exchange activity. Western blot analysis indicated that the amount of Na+-K+-ATPase protein had increased 2.1-fold in crabs acclimated 3 wk to DSW; however, 4 h after DSW transfer no difference in the amount of Na+-K+-ATPase protein was observed. After DSW transfer branchial cAMP content decreased. A negative correlation between branchial Na+-K+-ATPase activity and cAMP content points to rapid regulation of Na+-K+-ATPase through cAMP-dependent protein kinase A activity. Ca2+ transport may depend on the high capacity Na+/Ca2+ exchanger coupled to the versatile sodium pump. PMID- 9950928 TI - Chronic exercise increases macrophage-mediated tumor cytolysis in young and old mice. AB - In this study, we determined the effects of age and chronic treadmill running (16 wk; 5 days/wk; 45 min/day; 18-22 m/min) on resident peritoneal macrophage responsiveness to interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) in young (6 mo) and aged (22 mo) male BALB/cByJ mice by measuring cytolytic ability and production of reactive nitrogen products. Macrophages (>90% Mac-3(+)) were incubated with various concentrations of IFN-gamma and LPS for 24 h. After washing, P815 tumor cells were utilized as targets in a 16-h 51Cr release assay. We found that aging resulted in a significant reduction in the ability of macrophages to respond to the highest doses of IFN-gamma and LPS and kill P815 cells (46 +/- 4 vs. 34 +/- 2% in young and old mice, respectively). Exercise training significantly increased macrophage cytolysis in both age groups (66 + 7 vs. 44 + 2% in young and old mice, respectively); this effect was larger in the young mice. Macrophages from young exercised mice also produced significantly (50 60%) more NO-2; there was a tendency for higher NO-2 in old exercisers. The inducible nitric oxide synthase (iNOS) inhibitor NG-monomethyl-L-arginine (L NMMA) significantly reduced macrophage cytolysis and NO-2 production and completely abrogated exercise-induced increases in these measures. RT-PCR analysis revealed significantly higher iNOS mRNA levels in macrophages obtained from the exercise-trained mice and significantly lower iNOS mRNA in old compared with young mice. We conclude that aging reduces and exercise training increases the capacity of resident peritoneal macrophages to respond to IFN-gamma and LPS with increased tumor cytolysis. Enhanced iNOS gene expression and NO-2 production are likely the contributing mechanisms of the exercise-induced enhancement of cytolysis in young mice. While L-NMMA did block the exercise-induced increase in cytolysis, exercise did not increase NO-2 or iNOS gene expression in the old mice, indicating perhaps the contribution of other cytolytic mechanisms in old mice. PMID- 9950930 TI - Circadian blood pressure and heart rate rhythms in mice. AB - The circadian pattern of mean arterial pressure (MAP) and heart rate (HR) was measured in C57BL mice with carotid arterial catheters. Cardiovascular parameters were recorded continuously with a computerized monitoring system at a sampling rate of 100 Hz. The tethered animals were healthy, showing stabilized drinking and eating patterns within 2 days of surgery and little loss of body weight. Analysis of the 24-h pattern of MAP and HR was conducted using data from 3-6 consecutive days of recording. A daily rhythm of MAP was evident in all mice, with group mean dark and light values of 101.4 +/- 7.3 and 93.1 +/- 2.9 mmHg, respectively. The group mean waveform was bimodal, with peak values evident early and late in the dark period, and a trough during the middle of the light period. The phase of maximum and minimum values showed low within-group variance. Mean heart rate was greater at night than during the day (561.9 +/- 22.7 vs. 530.3 +/- 22.3 beats/min). Peak values generally occurred at dark onset, and minimum values during the middle of both the dark and the light periods. We conclude that it is possible to perform measurements of circadian cardiovascular parameters in the mouse, providing new avenues for the investigation of genetic models. PMID- 9950931 TI - O2 consumption and heart rate in developing zebrafish (Danio rerio): influence of temperature and ambient O2. AB - Body mass, length, oxygen consumption (MO2) and heart rate (fH) were measured in "embryos" (prior to hatching), "larvae" (days 10-20), "juveniles" (days 30-70 in 10-day intervals), and "adults" (day 100) of the zebrafish Danio rerio. Fish were chronically reared at either 25, 28, or 31 degreesC and then acutely exposed to hypoxia at different developmental stages. We hypothesized that at any given rearing and measurement temperature, D. rerio would maintain MO2 at lower ambient PO2 [i.e., have a lower critical partial pressure (Pcrit)] as development progressed and that at any given developmental stage individuals reared and measured at higher temperatures would show a more pronounced hypoxic bradycardia. MO2 in normoxic fish at 28 degreesC peaked at approximately 40 micromol. g-1. h-1 at day 10, thereafter falling to 4-5 micromol. g-1. h-1 at day 100. The Q10 for MO2 was 4-5 in embryos, falling to 2-3 from day 10 to day 60 and rising again to 4-5 at day 100. Pcrit at 28 degreesC was approximately 80 mmHg in embryos but decreased sharply to 20 mmHg at 100 days, supporting the hypothesis that more mature fish would be better able to oxygen regulate to lower ambient PO2 levels. Pcrit increased sharply with measurement temperature. Heart rate (fH) at 28 degreesC increased from about 125 beats/min in embryos to a peak of approximately 175 beats/min at days 10-30 and then fell to approximately 130 beats/min by day 100. Unlike for MO2, the Q10 for fH was more constant at 1.2-2.5 throughout development. Hypoxic exposure at any temperature had no effect on fH until approximately day 30, after which time a hypoxic bradycardia was evident. As evident for MO2, the bradycardia in older larvae was more profound at higher temperatures. On the assumption that bradycardia is indicative of hypoxic stress, the increasing prevalence of a hypoxic bradycardia in older, warmer individuals supports the hypothesis that increasing hypoxic susceptibility with development would be exacerbated by increasing temperature. Collectively, these data indicate that the ability to regulate MO2 and fH in response to the compounding demands of increased temperature and/or decreased oxygen availability first develops after approximately 20 days in D. rerio and, thereafter, the ability to maintain MO2 in the face of ambient hypoxia progressively builds through to adulthood. Additionally, the temperature responses of metabolism and heart rate differ substantially at different phases of development, suggesting a loose coupling between the respiratory and cardiovascular systems, at least early in development. PMID- 9950932 TI - Actions of amylin on subfornical organ neurons and on drinking behavior in rats. AB - Amylin, a peptide hormone secreted by pancreatic beta-cells after food intake, contributes to metabolic control by regulating nutrient influx into the blood, whereas insulin promotes nutrient efflux and storage. We now report that amylin activates neurons in the subfornical organ (SFO), a structure in which the lack of a functional blood-brain barrier and the presence of a high density of amylin receptors may render it accessible and sensitive to circulating amylin. In an in vitro slice preparation of the rat SFO, 73% of 78 neurons were excited by superfusion with rat amylin (10(-8)-10(-7) M); the remainder were insensitive. The threshold concentration for the excitatory response of amylin was <10(-8) M and thus similar in potency to a previously reported excitatory effect of ANG II on the same neurons. The excitatory effect of amylin was completely blocked by coapplication of the selective amylin receptor antagonist AC-187 (10(-6)-10(-5) M) but was not affected by losartan (10(-5) M). Subcutaneous injections of 40 nmol of amylin significantly increased water intake in euhydrated rats, as did an equimolar dose of ANG II, which is a well-described SFO-mediated effect of circulating ANG II. These results point to the SFO as a sensory central nervous target for amylin released systemically in response to metabolic changes. Furthermore, we suggest that amylin release during food intake may stimulate prandial drinking. PMID- 9950933 TI - Sleep after arousal from hibernation is not homeostatically regulated. AB - Electroencephalographic slow-wave activity (SWA) in non-rapid eye movement (NREM) sleep is directly related to prior sleep/wake history, with high levels of SWA following extended periods of wake. Therefore, SWA has been thought to reflect the level of accumulated sleep need. The discovery that euthermic intervals between hibernation bouts are spent primarily in sleep and that this sleep is characterized by high and monotonically declining SWA has led to speculation that sleep homeostasis may play a fundamental role in the regulation of the timing of bouts of hibernation and periodic arousals to euthermia. It was proposed that because the SWA profile seen after arousal from hibernation is strikingly similar to what is seen in nonhibernating mammals after extended periods of wakefulness, that hibernating mammals may arouse from hibernation with significant accumulated sleep need. This sleep need may accumulate during hibernation because the low brain temperatures during hibernation may not be compatible with sleep restorative processes. In the present study, golden-mantled ground squirrels were sleep deprived during the first 4 h of interbout euthermia by injection of caffeine (20 mg/kg ip). We predicted that if the SWA peaks after bouts of hibernation reflected a homeostatic response to an accumulated sleep need, sleep deprivation should simply have displaced and possibly augmented the SWA to subsequent recovery sleep. Instead we found that after caffeine-induced sleep deprivation of animals just aroused from hibernation, the anticipated high SWA typical of recovery sleep did not occur. Similar results were found in a study that induced sleep deprivation by gentle handling (19). These findings indicate that the SWA peak immediately after hibernation does not represent homeostatic regulation of NREM sleep, as it normally does after prolonged wakefulness during euthermia, but instead may reflect some other neurological process in the recovery of brain function from an extended period at low temperature. PMID- 9950934 TI - Stimulated mechanisms of Ca2+ entry into vascular smooth muscle during NO synthesis inhibition in pregnant rats. AB - We have previously found that the vascular responsiveness to alpha1-adrenergic agonists is reduced in pregnant rats and enhanced in a rat model of pregnancy induced hypertension produced by chronic treatment of pregnant rats with the nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME). The purpose of this study was to investigate whether the observed changes in vascular reactivity during normal pregnancy and during pregnancy-induced hypertension reflect changes in the mechanisms of Ca2+ entry into vascular smooth muscle. 45Ca2+ influx and active stress during alpha1-adrenergic stimulation by phenylephrine and membrane depolarization by 96 mM KCl were measured in deendothelialized aortic strips isolated from virgin and pregnant Sprague-Dawley rats untreated or treated with 1 mg/day L-NAME for 4-6 days and incubated in Krebs solution containing increasing concentrations of extracellular Ca2+ ([Ca2+]e). In all groups of rats, both phenylephrine and 96 mM KCl caused [Ca2+]e dependent increases in active stress and 45Ca2+ influx. The phenylephrine- and 96 mM KCl-induced active stress and Ca2+ influx were significantly reduced in pregnant rats but significantly enhanced in pregnant rats treated with L-NAME. The phenylephrine-induced Ca2+ influx-stress relationship was significantly greater than that induced by 96 mM KCl in pregnant rats treated with L-NAME. The phenylephrine-induced Ca2+ influx-stress relationship was reduced in pregnant rats but enhanced in pregnant rats treated with L-NAME. Chronic treatment with L NAME had minimal effect on active stress, Ca2+ influx, and the Ca2+ influx-stress relationship in virgin rats. These results provide evidence that the mechanisms of Ca2+ entry into vascular smooth muscle are inhibited during pregnancy but enhanced during inhibition of NO synthesis in late pregnancy. The enhancement of the phenylephrine-induced Ca2+ influx-stress relationship in pregnant rats treated with L-NAME suggests activation of other contractile mechanisms in addition to stimulation of Ca2+ entry. These mechanisms appear to be inhibited during normal pregnancy. PMID- 9950935 TI - Renal hemodynamic effects of activation of specific renal sympathetic nerve fiber groups. AB - To examine the effect of activation of a unique population of renal sympathetic nerve fibers on renal blood flow (RBF) dynamics, anesthetized rats were instrumented with a renal sympathetic nerve activity (RSNA) recording electrode and an electromagnetic flow probe on the ipsilateral renal artery. Peripheral thermal receptor stimulation (external heat) was used to activate a unique population of renal sympathetic nerve fibers and to increase total RSNA. Total RSNA was reflexly increased to the same degree with somatic receptor stimulation (tail compression). Arterial pressure and heart rate were increased by both stimuli. Total RSNA was increased to the same degree by both stimuli but external heat produced a greater renal vasoconstrictor response than tail compression. Whereas both stimuli increased spectral density power of RSNA at both cardiac and respiratory frequencies, modulation of RBF variability by fluctuations of RSNA was small at these frequencies, with values for the normalized transfer gain being approximately 0.1 at >0.5 Hz. During tail compression coherent oscillations of RSNA and RBF were found at 0.3-0.4 Hz with normalized transfer gain of 0.33 +/ 0.02. During external heat coherent oscillations of RSNA and RBF were found at both 0.2 and 0.3-0.4 Hz with normalized transfer gains of 0. 63 +/- 0.05 at 0.2 Hz and 0.53 +/- 0.04 to 0.36 +/- 0.02 at 0.3-0.4 Hz. Renal denervation eliminated the oscillations in RBF at both 0.2 and 0.3-0.4 Hz. These findings indicate that despite similar increases in total RSNA, external heat results in a greater renal vasoconstrictor response than tail compression due to the activation of a unique population of renal sympathetic nerve fibers with different frequency-response characteristics of the renal vasculature. PMID- 9950936 TI - Heat acclimation induces changes in cardiac mechanical performance: the role of thyroid hormone. AB - The involvement of reduced thyroxine level in the emergence of heat acclimation induced negative lusitropic effect was examined. Experiments were carried out on 1) control rat hearts maintained at 24 +/- 1 degreesC (C); 2) rat hearts acclimated at 34 degreesC for 1 mo (AC); 3) AC-euthyroid rat hearts, via administration of thyroxine in the drinking water (AT); and 4) hypothyroid rat hearts, maintained at 24 +/- 1 degreesC, via administration of thiouracil in the drinking water (CP). Systolic pressure and velocities of contraction (dP/dt. P) and relaxation (-dP/dt. P) were measured using the Langendorff perfusion system. The steady-state levels of Ca2+-ATPase and phospholamban mRNAs and the expression of the encoded proteins Ca2+-ATPase (SERCA) and phospholamban (PLB) were measured, using semi-quantitative RT-PCR and Western immunoblotting, respectively. Rat thyroxine levels were measured using RIA. Heat acclimation, which brought about a reduced thyroxine level, led to downregulation of Ca2+ ATPase mRNA expression and translation and upregulation of phospholamban mRNA and PLB. Consequently, the PLB-to-SERCA ratio (PLB/SERCA) of the AC hearts showed a significant increase. These changes, as well as the greater pressure generation and the reduced dP/dt. P and -dP/dt. P observed in AC hearts were blunted in the AT hearts. Our data suggest that sustained heat acclimation-induced low thyroxine level has a decisive effect on the contractile machinery of the AC heart. Elevated PLB/SERCA apparently explains the negative lusitropic effect observed in these hearts. PMID- 9950937 TI - Metabolic and contractile influence of carbonic anhydrase III in skeletal muscle is age dependent. AB - Carbonic anhydrase (CA) III is very abundant in type I skeletal muscle, but its function is still debated. Our aims were to examine CA III expression during growth and determine whether the effects of CA inhibition previously observed in adult muscles could be seen in younger rats in which CA III levels are lower. CA III content and activity were measured in soleus muscles from 10- to 100-day-old rats, and the influence of CA inhibitor on fatigue and hexosemonophosphate content was quantified in vitro. CA III activity and content increased fivefold between 10 and 100 days of age. Data analysis revealed that the influence of CA inhibitor on fatigue was to some extent positively and linearly related to the level of CA III activity. Hexosemonophosphate accumulation with CA inhibition also became more significant with age. In conclusion, CA III level in soleus muscle does not stabilize before 3 mo after birth; data also confirm that the effects of CA inhibitors are due to inhibition of the CA III isoform. PMID- 9950938 TI - ATP-dependent calcium uptake into basolateral vesicles from transporting epithelia of intermolt crayfish. AB - ATP-dependent Ca2+ uptake was determined into inside-out basolateral membrane vesicles (BLMV) from intermolt crayfish (Procambarus clarkii) Ca2+-transporting epithelia: gill, hepatopancreas (liver), and antennal gland (kidney). Extravesicular (EV) ATP (5 mM) increased 45Ca2+ uptake (free Ca2+ 5 microM) by fivefold but was abolished by pretreatment with either vanadate or the ionophore A-23187. Addition of A-23187 to Ca2+-loaded vesicles produced 70% efflux. The saturable carrier exhibited a Km for Ca2+ of 0.11-0.27 microM and maximal influx of 20-123 pmol. mg-1. min-1. The Km for ATP was 0.01-0.04 mM. The temperature coefficient ranged from 1.43 to 2.06. EGTA treatment of hepatopancreas and antennal gland vesicles decreased 45Ca2+ uptake by 50-90%; uptake was restorable by calmodulin. However, in gill, 45Ca2+ uptake was unaffected by EGTA treatment and calmodulin decreased uptake in both EGTA-treated and untreated vesicles. Addition of EV Na+ (5 mM) increased ATP-dependent Ca2+ uptake into hepatopancreas and antennal gland BLMV by 60%; in hepatopancreas BLMV, this increase was inhibitable by ouabain. However, ATP-dependent Ca2+ uptake in gill vesicles was Na+ independent. The relative role of each epithelium in whole animal Ca2+ homeostasis has been interpreted based on in vitro characteristics. PMID- 9950939 TI - Effect of Ca2+ agonists in the perfused liver: determination via laser scanning confocal microscopy. AB - Ca2+ is a critical intracellular second messenger, but few studies have examined Ca2+ signaling in whole organs. The amplitude and frequency of Ca2+ oscillations encode important cellular information. Using laser scanning confocal microscopy in the indo 1 acetoxymethyl ester dye-loaded rat liver, we investigated the effect of various Ca2+ agonists that act at distinct mechanistic sites on Ca2+ signaling. Perfusion with suprathreshold doses of arginine vasopressin (AVP) (2 20 nM) caused a single Ca2+ wave that originated in the pericentral vein region and spread centrifugally to the periportal area. Lower doses of AVP (0.2-2 nM) caused multiple Ca2+ waves and Ca2+ oscillations. Perfusion with ATP (1. 4-17.5 microM) caused rapid transient elevations in intracellular free Ca2+ concentration ([Ca2+]i) occurring in isolated hepatocytes or groups of hepatocytes throughout the lobule and were of shorter duration than those due to AVP. Also in contrast to AVP, there was no specific anatomic location within the hepatic lobule that was more susceptible to ATP. Thapsigargin and cyclopiazonic acid did not cause a Ca2+ wave but rather produced a uniform and fairly simultaneous increase in [Ca2+]i in all hepatocytes in the lobule. Perfusion with 14 microM ryanodine produced a single transient spike in [Ca2+]i in a small number (<2%) of hepatocytes. Dantrolene, an inhibitor of Ca2+ release, reduced the increased [Ca2+]i occurring after AVP. Insight into the mechanism of action of these Ca2+-active compounds on Ca2+ signaling in the intact liver is provided. PMID- 9950940 TI - AMPA receptor activation of area postrema neurons. AB - This study reports on the effects of activation of ionotropic glutamate receptors on area postrema neuron cytosolic calcium concentration ([Ca2+]i). In 140 of 242 area postrema neurons isolated from postnatal rats, application of 100 microM L glutamate (L-Glu) resulted in a significant increase in [Ca2+]i. The remaining neurons were unaffected. The effects of L-Glu on area postrema [Ca2+]i were dose dependent, with a threshold of response near 1.0 microM and maximal response near 100 microM. To determine if the response of L-Glu in area postrema neurons was due to activation of ionotropic glutamate receptors, the effects of the broad spectrum ionotropic glutamate receptor antagonist kynurinic acid (Kyn) was determined. Application of 1.0 mM Kyn resulted in a 62.6 +/- 4% inhibition of the L-Glu-evoked response. Application of the selective N-methyl-D-aspartic acid (NMDA) antagonist 2-amino-5-phosphonopentanoic acid had no effect on the response of area postrema neurons to 100 microM L-Glu. In contrast, application of the selective DL-alpha-amino-3-hydroxy-5-methylisoxazole-propionic acid (AMPA)/kainate receptor antagonist 6,7-dinitroquinoxaline (DNQX) effectively blocked the 100 microM L-Glu response. Application of (+/-)-AMPA mimicked the effects observed with L-Glu and was selectively blocked by DNQX. These results suggest that L-Glu activation of area postrema neurons involves activation of AMPA receptors but not NMDA receptors. PMID- 9950941 TI - Regulation of fiber size, oxidative potential, and capillarization in human muscle by resistance exercise. AB - To examine the hypothesis that increases in fiber cross-sectional area mediated by high-resistance training (HRT) would result in a decrease in fiber capillarization and oxidative potential, regardless of fiber type, we studied six untrained males (maximum oxygen consumption, 45.6 +/- 2.3 ml. kg-1. min-1; mean +/- SE) participating in a 12-wk program designed to produce a progressive hypertrophy of the quadriceps muscle. The training sessions, which were conducted 3 times/wk, consisted of three sets of three exercises, each performed for 6-8 repetitions maximum (RM). Measurements of fiber-type distribution obtained from tissue extracted from the vastus lateralis at 0, 4, 7, and 12 wk indicated reductions (P < 0.05) in type IIB fibers (15.1 +/- 2.1% vs. 7.2 +/- 1.3%) by 4 wk in the absence of changes in the other fiber types (types I, IIA, and IIAB). Training culminated in a 17% increase (P < 0.05) in cross-sectional area by 12 wk with initial increases observed at 4 wk. The increase was independent of fiber type-specific changes. The number of capillaries in contact with each fiber type increased by 12 wk, whereas capillary contacts-to-fiber area ratios remained unchanged. In a defined cross-sectional field, HRT also increased the capillaries per fiber at 12 wk. Training failed to alter cellular oxidative potential, as measured by succinic dehydrogenase (SDH) activity, regardless of fiber type and training duration. It is concluded that modest hypertrophy induced by HRT does not compromise cellular tissue capillarization and oxidative potential regardless of fiber type. PMID- 9950942 TI - Measurement of gastric emptying during and between meal intake in free-feeding Lewis rats. AB - A new scintigraphic measurement technique is described that allows accurate assessment of gastric emptying in between as well as during a number of successive meals. Measurements were made every minute of food intake, gastric nutrient filling, and gastric emptying over a 6 h, 40 min period in conscious, free-feeding, loosely restrained rats. Before receiving access to the food, the animals had been deprived for a period of 31 h. Over the full duration of the experiment, an average rate of gastric emptying of 2.46 +/- 0.18 (SE) kcal/h was established. During most meals, however, the gastric emptying rate was increased so that an average of 26.9 +/- 2.7% of the ingested calories was emptied while the animals were feeding, with an average emptying rate of 0.15 +/- 0.014 kcal/min or 8.88 +/- 0.84 kcal/h. This transient increase in the rate of gastric emptying was followed by a subsequent slowing of gastric emptying after meal termination; in the 10-min postmeal interval, an average emptying rate of 0.96 +/ 0.12 kcal/h was found. Despite these fluctuations during and immediately after meals, a relatively constant rate of caloric emptying is maintained over longer periods. There were no differences between the emptying rate during the first meal when the gastrointestinal tract was still empty, compared with later meals when the gastrointestinal tract had been filled with food. The emptying rate during the 10-min postmeal interval, however, was significantly reduced during later meals. The results suggest that gastric emptying is controlled by different mechanisms during and after the ingestion of food and that these mechanisms remain in effect at various degrees of gastrointestinal filling. PMID- 9950943 TI - Leptin disinhibits nonshivering thermogenesis in infants after maternal separation. AB - Prolonged maternal separation inhibits endogenous heat production in infant mammals exposed to cold. This inhibition of thermogenesis occurs many hours before energy stores have been fully depleted. The need to protect energy resources during separation-induced starvation may be signaled by declining levels of leptin, a hormone that acts as a "fat signal" and a regulator of energy utilization; in fact, starvation reduces leptin levels in adult mice and infant rats. It is not known, however, whether leptin has a functional role during starvation in infants. Such a role may be found in the regulation of nonshivering thermogenesis by brown adipose tissue (BAT), a specialized organ that provides heat to infant mammals, including humans, during cold exposure. Heat produced by BAT allows the cold-exposed infant to prevent the detrimental effects of hypothermia on physiology and behavior and, ultimately, growth. Here we show that leptin disinhibits BAT thermogenesis during cold exposure in infant rats after 18 h of maternal separation. This finding demonstrates that leptin is more than simply an adipostat for the regulation of body weight; specifically, leptin modulates thermogenesis and energy utilization in the early postnatal period. PMID- 9950944 TI - Chronic eccentric exercise: improvements in muscle strength can occur with little demand for oxygen. AB - Eccentric contractions, the lengthening of muscle while producing force, are a common part of our everyday movements. This study presents a challenge to the accepted notion that eccentric work causes obligatory muscle injury while demonstrating that an increase in muscle strength, via eccentric work, can occur with little demand for oxygen. Nine healthy subjects, ages 18-34, were randomly placed in either an eccentric or a concentric training group. Both groups trained for 6 wk while progressively increasing training frequency and duration. Significant gains in isometric leg strength were seen in the eccentrically trained subjects only. While training, the oxygen consumption required to do the eccentric work was equal to or less than that required to do the concentric work. The results demonstrate that by progressively increasing the eccentric work rate, significant isometric strength gains can be made without muscle injury and with minimal increase in metabolic demand for oxygen. The potential clinical implications of an eccentric training program that uncouples skeletal muscle strength improvements from the demand for oxygen are alluring. PMID- 9950945 TI - Elevation of basolateral K+ induces K+ secretion by apical maxi K+ channels in Ambystoma collecting tubule. AB - We previously reported that exposure of aquatic-phase Ambystoma tigrinum to a solution containing 50 mM K+ (K+ adaptation) caused a nearly 10-fold increase in the number of detectable maxi K+ channels on the apical membrane of their initial collecting tubules. In apparent contradiction to the notion that maxi K+ channels contribute to K+ secretion, these channels were not routinely active at the resting membrane potential (0 mV voltage clamp). To test the possibility that hyperkalemia yields maxi K+ channels that are secreting K+ (i.e., active at 0 mV), we patch-clamped the apical membranes of initial collecting tubules under conditions of elevated basolateral K+ (15 mM). Seven patches containing maxi K+ channels were studied. Six of the seven patches showed maxi K+ channel activity when voltage was clamped at 0 mV. Open probability and unitary current averaged 0.059 +/- 0.016 and 1.65 +/- 0.50 pA, respectively. This activity, together with the high density of channels observed (1.06 channels/micrometer2), indicates that after K+ adaptation, maxi K+ channels contribute to the ability of the late distal nephron of amphibians to secrete K+. PMID- 9950946 TI - Molecular characterization of an elasmobranch urea transporter. AB - Marine elasmobranch fishes retain relatively high levels of urea to balance the osmotic stress of living in seawater. To maintain osmotic balance and reduce the energetic costs of making urea, it is important for these animals to minimize urea excretion to the environment. We have isolated a novel 2.2-kb cDNA from Squalus acanthias (spiny dogfish shark) kidney encoding a 380-amino acid hydrophobic protein (ShUT) with 66% identity to the rat facilitated urea transporter protein UT-A2. Injection of ShUT cRNA into Xenopus oocytes induced a 10-fold increase in 14C-labeled urea uptake, inhibitable by phloretin (0.35 mM). ShUT mRNA is expressed in kidney and brain. Related mRNA species are found in liver, blood, kidney, gill, intestine, muscle, and rectal gland. This is the first facilitated urea transporter to be identified in a marine fish. We propose that the ShUT protein is involved in urea reabsorption by the renal tubules of the dogfish shark, which in turn minimizes urea loss in the urine. PMID- 9950947 TI - Expression of Na+-D-glucose cotransporter in brush-border membrane of the chicken intestine. AB - We have studied the expression of Na+-D-glucose cotransporter in brush-border membrane vesicles (BBMVs) of chicken enterocytes to correlate the changes in the apical Na+-dependent transport with the changes in the amounts of transporter determined by Western blot analysis. Two different rabbit polyclonal antibodies were used simultaneously. The antibody raised against amino acids 564-575 of the deduced amino acid sequence of rabbit intestinal SGLT-1 (antibody 1) specifically detects a single 75-kDa band in the three segments, and this band disappeared when the antibody was preabsorbed with the antigenic peptide. The antibody raised against the synthetic peptide corresponding to amino acids 402-420 of the same protein (antibody 2) only reacts with jejunal and ileal samples, but no signal is found in BBMVs of rectum. Only when antibody 1 was used was there a linear correlation between the maximal transport rates of hexoses in BBMVs and the relative protein amounts determined by Western blot. These results indicate that the Na+-D-glucose cotransport in the jejunum, the ileum, and the rectum of chickens is due to an SGLT-1 type protein. PMID- 9950948 TI - Low aquaporin-2 levels in polyuric DI +/+ severe mice with constitutively high cAMP-phosphodiesterase activity. AB - In the renal collecting duct, vasopressin acutely activates cAMP production, resulting in trafficking of aquaporin-2 water channels (AQP2) to the apical plasma membrane, thereby increasing water permeability. This acute response is modulated by long-term changes in AQP2 expression. Recently, a cAMP-responsive element has been identified in the AQP2 gene, raising the possibility that changes in cAMP levels may control AQP2 expression. To investigate this possibility, we determined AQP2 protein levels in a strain of mice, DI +/+ severe (DI), which have genetically high levels of cAMP-phosphodiesterase activity, and hence low cellular cAMP levels, and severe polyuria. Semiquantitative immunoblotting of membrane fractions prepared from whole kidneys revealed that AQP2 levels in DI mice were only 26 +/- 7% (+/-SE) of those in control mice (n = 10, P < 0.01). In addition, semiquantitative Northern blotting revealed a significantly lower AQP2 mRNA expression in kidneys from DI mice compared with control mice (43 +/- 6% vs. 100 +/- 10%; n = 6 in each group, P < 0.05). AQP3 levels were also reduced. The mice were polyuric and urine osmolalities were accordingly substantially lower in the DI mice than in controls (496 +/- 53 vs. 1,696 +/- 105 mosmol/kgH2O, respectively). Moreover, there was a linear correlation between urine osmolalities and AQP2 levels (P < 0.05). Immunoelectron microscopy confirmed the markedly lower expression of AQP2 in collecting duct principal cells in kidneys of DI mice and, furthermore, demonstrated that AQP2 was almost completely absent from the apical plasma membrane. Thus expression of AQP2 and AQP2 trafficking were severely impaired in DI mice. These results are consistent with the view that in vivo regulation of AQP2 expression by vasopressin is mediated by cAMP. PMID- 9950949 TI - Lysophosphatidic acid-induced calcium mobilization and proliferation in kidney proximal tubular cells. AB - Patients with proteinuria tend to develop progressive renal disease with proximal tubular cell atrophy and interstitial scarring. It has been suggested that the nephrotoxicity of albuminuric states may be due to the protein molecule itself or by lipids, such as lysophosphatidic acid (LPA), that albumin carries. LPA was found to cause a transient increase in intracytoplasmic free Ca2+ ([Ca2+]i) in opossum kidney proximal tubule cells (OK) that was maximal at 100 microM LPA and was dose dependent with an EC50 of 2.6 x 10(-6) M. This Ca2+ mobilization was from both internal stores and across the plasma membrane and was pertussis toxin (PTX) insensitive. Treatment of OK cells with 100 microM LPA for 5 min was found to cause a twofold increase in [3H]thymidine incorporation and a three- to fivefold increase over control after 24 h. This was highly PTX sensitive and insensitive to pretreatment with the tyrosine kinase inhibitors genistein and herbimycin A. These findings may be of significance in the progression of renal disease and indicate the potential importance of lipids in modulating proximal tubule cell function and growth. PMID- 9950950 TI - VACM-1 receptor is specifically expressed in rabbit vascular endothelium and renal collecting tubule. AB - The vasopressin-activated calcium-mobilizing (VACM-1) protein is a novel arginine vasopressin (AVP) receptor that shares sequence homology with a cullin multigene family but not with the AVP receptors. To characterize the VACM-1 receptor, we examined its tissue-specific expression using Northern blot, RT-PCR, and immunostaining analyses. Northern blot hybridization identified a 6. 4-kb cRNA species that was expressed in the rabbit kidney medulla, brain, heart, and ovaries. In human tissue, VACM-1 mRNA is a larger (7.5 kb) cRNA found in the kidney, brain, heart, placenta, and skeletal muscle. VACM-1-specific RT-PCR products were detected in mRNA from rabbit kidney medulla, brain, heart, and mesenteric arteries. No expression of VACM-1 could be detected in rabbit aorta, gastrointestinal tract, or liver. Coimmunostaining with anti-VACM-1 antibodies (Ab) and a specific vascular endothelial cell marker, CD31 monoclonal Ab, localized VACM-1 expression to the vasculature in specific tissues. We identified the kidney cells expressing VACM-1 receptor by coimmunostaining with the following monoclonal Ab, which recognize epitopes in specific segments of the nephron: rct-30 Ab, reactive against the cortical and medullary collecting tubule (CT) cells; mr-omct Ab, reactive against the mitochondria-rich cells of the outer medullary CT; and an Ab specific against the loop of Henle segment. These studies indicated that the VACM-1 receptor is expressed only in the medullary CT. Kidney coimmunostaining with anti-VACM-1 and CD31 Ab identified VACM-1-receptor expression in glomeruli and medullary vascular bundles. These results demonstrate that the novel VACM-1 receptor, expressed in many organs, is localized to the endothelial cells. In the kidney, it is also expressed in the medullary CT cells. Thus VACM-1 may be involved in the regulation of endothelial permeability and water transport in the CT. PMID- 9950951 TI - Nuclear localization of beta-catenin and loss of apical brush border actin in cystic tubules of bcl-2 -/- mice. AB - Tight regulation of the rates of cell proliferation and apoptosis is critical for normal nephrogenesis. Nephrogenesis is profoundly affected by the loss of bcl-2 expression. Bcl-2-deficient (bcl-2 -/-) mice are born with renal hypoplasia and succumb to renal failure secondary to renal multicystic disease. Cell-cell and cell-matrix interactions impact tissue architecture by modulating cell proliferation, migration, differentiation, and apoptosis. E-cadherin mediates calcium-dependent homotypic cell-cell interactions that are stabilized by its association with catenins and the actin cytoskeleton. The contribution of altered cell-cell interactions to renal cystic disease has not been delineated. Cystic kidneys from bcl-2 -/- mice displayed nuclear localization of beta-catenin and loss of apical brush border actin staining. The protein levels of alpha-catenin, beta-catenin, actin, and E-cadherin were not altered in cystic kidneys compared with normal kidneys. Therefore, an altered distribution of beta-catenin and actin, in kidneys from bcl-2 -/- mice, may indicate improper cell-cell interactions interfering with renal maturation and contributing to renal cyst formation. PMID- 9950953 TI - Differential effects of EGF on repair of cellular functions after dichlorovinyl-L cysteine-induced injury. AB - This study examined the repair of renal proximal tubule cellular (RPTC) functions following sublethal injury induced by the nephrotoxicant S-(1,2-dichlorovinyl)-L cysteine (DCVC). DCVC exposure resulted in 31% cell death and loss 24 h following the treatment. Monolayer confluence recovered through migration/spreading but not proliferation after 6 days. Basal, uncoupled, and ouabain-sensitive oxygen consumption (QO2) decreased 47, 76, and 62%, respectively, 24 h after DCVC exposure. Na+-K+-ATPase activity and Na+-dependent glucose uptake were inhibited 80 and 68%, respectively, 24 h after DCVC exposure. None of these functions recovered over time. Addition of epidermal growth factor (EGF) following DCVC exposure did not prevent decreases in basal, uncoupled, and ouabain-sensitive QO2 values and Na+-K+-ATPase activity but promoted their recovery over 4-6 days. In contrast, no recovery of Na+-dependent glucose uptake occurred in the presence of EGF. These data show that: 1) DCVC exposure decreases mitochondrial function, Na+ K+-ATPase activity, active Na+ transport, and Na+-dependent glucose uptake in sublethally injured RPTC; 2) DCVC-treated RPTC do not proliferate nor regain their physiological functions in this model; and 3) EGF promotes recovery of mitochondrial function and active Na+ transport but not Na+-dependent glucose uptake. These results suggest that cysteine conjugates may cause renal dysfunction, in part, by decreasing RPTC functions and inhibiting their repair. PMID- 9950952 TI - Rat proximal tubule cell line transformed with origin-defective SV40 DNA: autocrine ANG II feedback. AB - The renal proximal tubule (PT) is a major site for a complete tissue renin angiotensin system (RAS) and produces endogenous angiotensin II (ANG II). The present studies demonstrate autocrine RAS feedback in a line of origin-defective SV40 plasmid transformed immortalized rat PT cells (IRPTC) designated as line 93 p-2-1, which are highly differentiated and express all RAS components. Receptor competition assays and Southern blot following RT-PCR demonstrated that these IRPTC express AT1 and AT2 angiotensin receptor subtypes. Autocrine RAS feedback was examined following exposure to ANG II (10(-8) M), and it was noted that angiotensinogen mRNA increases significantly by 1 h and remains elevated through 24 h. The AT1 blocker losartan prevents this increase. Moreover, ANG II upregulates expression of ANG II receptor mRNA (both AT1 and AT2). Thus the present studies demonstrate positive ANG II feedback with angiotensinogen and ANG II receptors in PTC, suggesting that the main site of such intrarenal feedback in vivo is within PT. ANG II secreted by line 93-p-2-1 is increased by isoproterenol, suggesting beta-adrenergic regulation in IRPTC. PMID- 9950954 TI - H-K-ATPase in the RCCT-28A rabbit cortical collecting duct cell line. AB - In the present study, we demonstrate that the rabbit cortical collecting duct cell line RCCT-28A possesses three distinct H-K-ATPase catalytic subunits (HKalpha). Intracellular measurements of RCCT-28A cells using the pH-sensitive dye 2', 7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) indicated that the mechanism accounting for recovery from an acid load exhibited both K+ dependence and sensitivity to Sch-28080 characteristic of H-K-ATPases. Recovery rates were 0.022 +/- 0.005 pH units/min in the presence of K+, 0.004 +/- 0.002 in the absence of K+, and 0.002 +/- 0.002 in the presence of Sch-28080. The mRNAs encoding the HKalpha1 subunit and the H-K-ATPase beta-subunit (HKbeta) were detected by RT-PCR. In addition, two HKalpha2 species were found by RT-PCR and 5' rapid amplification of cDNA ends (5'-RACE) in the rabbit renal cortex. One was homologous to HKalpha2 cDNAs generated from other species, and the second was novel. The latter, referred to as HKalpha2c, encoded an apparent 61-residue amino terminal extension that bore no homology to reported sequences. Antipeptide antibodies were designed on the basis of this extension, and these antibodies recognized a protein of the appropriate mass in both rabbit renal tissue samples and RCCT-28A cells. Such findings constitute very strong evidence for expression of the HKalpha2c subunit in vivo. The results suggest that the rabbit kidney and RCCT-28A cells express at least three distinct H-K-ATPases. PMID- 9950955 TI - Contribution of cytochrome P-450 4A1 and 4A2 to vascular 20 hydroxyeicosatetraenoic acid synthesis in rat kidneys. AB - 20-Hydroxyeicosatetraenoic acids (20-HETE), a biologically active cytochrome P 450 (CYP) metabolite of arachidonic acid in the rat kidney, can be catalyzed by CYP4A isoforms including CYP4A1, CYP4A2, and CYP4A3. To determine the contribution of CYP4A isoforms to renal 20-HETE synthesis, specific antisense oligonucleotides (ODNs) were developed, and their specificity was examined in vitro in Sf9 cells expressing CYP4A isoforms and in vivo in Sprague-Dawley rats. Administration of CYP4A2 antisense ODNs (167 nmol. kg body wt-1. day-1 iv for 5 days) decreased vascular 20-HETE synthesis by 48% with no effect on tubular synthesis, whereas administration of CYP4A1 antisense ODNs inhibited vascular and tubular 20-HETE synthesis by 52 and 40%, respectively. RT-PCR of microdissected renal microvessel RNA indicated the presence of CYP4A1, CYP4A2, and CYP4A3 mRNAs, and a CYP4A1-immunoreactive protein was detected by Western analysis of microvessel homogenates. Blood pressure measurements revealed a reduction of 17 +/- 6 and 16 +/- 4 mmHg in groups receiving CYP4A1 and CYP4A2 antisense ODNs, respectively. These studies implicate CYP4A1 as a major 20-HETE synthesizing activity in the rat kidney and further document the feasibility of using antisense ODNs to specifically inhibit 20-HETE synthesis and thereby investigate its role in the regulation of renal function and blood pressure. PMID- 9950956 TI - Arginine vasopressin stimulates phosphorylation of aquaporin-2 in rat renal tissue. AB - Aquaporin-2 (AQP2), the protein that mediates arginine vasopressin (AVP) regulated apical water transport in the renal collecting duct, possesses a single consensus phosphorylation site for cAMP-dependent protein kinase A (PKA) at Ser256. The aim of this study was to examine whether AVP, and other agents that increase cAMP levels, could stimulate the phosphorylation of AQP2 in intact rat renal tissue. Rat renal papillae were prelabeled with 32P and incubated with vehicle or drugs, and then AQP2 was immunoprecipitated. Two polypeptides corresponding to nonglycosylated (29 kDa) and glycosylated (35-48 kDa) AQP2 were identified by SDS-PAGE. AVP caused a time- and dose-dependent increase in phosphorylation of both glycosylated and nonglycosylated AQP2. The threshold dose for a significant increase in phosphorylation was 10 pM, which corresponds to a physiological serum concentration of AVP. Maximal phosphorylation was reached within 1 min of AVP incubation. This effect on AQP2 phosphorylation was mimicked by the vasopressin (V2) agonist, 1-desamino-[8-D-arginine]vasopressin (DDAVP), or forskolin. Two-dimensional phosphopeptide mapping indicated that AVP and forskolin stimulated the phosphorylation of the same site in AQP2. Immunoblot analysis using a phosphorylation state-specific antiserum revealed an increase in phosphorylation of Ser256 after incubation of papillae with AVP. The results indicate that AVP stimulates phosphorylation of AQP2 at Ser256 via activation of PKA, supporting the idea that this is one of the first steps leading to increased water permeability in collecting duct cells. PMID- 9950957 TI - Exaggerated Ca2+ signaling in preglomerular arteriolar smooth muscle cells of genetically hypertensive rats. AB - Experiments were conducted to gain insight into mechanisms responsible for exaggerated renal vascular reactivity to ANG II and vasopressin (AVP) in spontaneously hypertensive rats (SHR) during the development of hypertension. Cytosolic calcium concentration ([Ca2+]i) was measured by ratiometric fura 2 fluorescence and a microscope-based photometer. Vascular smooth muscle cells (SMC) from preglomerular arterioles were isolated and dispersed using an iron oxide-sieving method plus collagenase treatment. ANG II and AVP produced rapid and sustained increases in [Ca2+]i. ANG II elicited similar dose-dependent increases in [Ca2+]i in SMC from SHR and Wistar-Kyoto rats (WKY). In contrast, AVP caused almost twofold larger responses in afferent arteriolar SMC from SHR. ANG II effects were inhibited by the AT1 receptor antagonist losartan. AVP action was blocked by the V1 receptor antagonist [d(CH2)5,Tyr(NH2)9]AVP. In SMC pretreated with nifedipine, neither ANG II nor AVP elicited [Ca2+]i responses. Poststimulation nifedipine reversed elevated [Ca2+]i to basal levels. Short-term reductions in external [Ca2+]i (EGTA) mimicked the nifedipine effects. Our study shows that AT1 and V1 receptors stimulate [Ca2+]i by a common mechanism characterized by preferential action on voltage-gated L-type channels sensitive to dihydropyridines. Calcium signaling elicited by AT1 receptors does not differ between SHR and WKY; thus the in vivo exaggerated reactivity may be dependent on interactions with other cell types, e. g., endothelium. In contrast, AVP produced larger changes in [Ca2+]i in arteriolar SMC from SHR, and such direct effects can account for the exaggerated renal blood flow responses. PMID- 9950958 TI - Kinin influences on renal regional blood flow responses to angiotensin-converting enzyme inhibition in dogs. AB - The relative roles of ANG II and bradykinin (BK) in the regulation of renal medullary circulation have remained unclear. We compared the contributions of ANG II and BK to the renal medullary blood flow (MBF) responses to angiotensin converting enzyme (ACE) inhibition (enalaprilat, 33 micrograms . kg-1. min-1) in dogs maintained on a normal-salt diet (0.63%, 3 days, n = 14; group 1) with those fed a low-salt diet (0.01%, 5 days, n = 14; group 2), which upregulates both the kallikrein-kinin and the renin-angiotensin systems. MBF responses to ACE inhibition were evaluated either before (n = 7) or after (n = 7) treatment with the BK B2 receptor blocker icatibant (100-300 micergrams) in both groups. Laser Doppler needle flow probes were used to determine relative changes in MBF and cortical blood flow (CBF). ACE inhibition increased MBF (group 1, 33 +/- 9%, P 70%; FEV1/FVC >70%) by contrast transesophageal echocardiography during the Valsalva maneuver with simultaneous measurement of systemic arterial oxygen saturation (SaO2) by pulse oximetry. Patients with severe COPD (FEV1 = 27.2% +/- 8.4%; FEV1 /FVC = 44.3% +/- 11.0%) had a significantly higher pulmonary artery systolic pressure (38.3 +/- 7.3 vs 21.0 +/- 2.4 mm Hg; P <.005), higher prevalence of PFO (14/20 = 70% vs 7/20 = 35%; P <.05), and greater systemic arterial desaturation after Valsalva (Sao2 change: -2.6% +/- 1.4% vs -1.1% +/- 0.9%; P <.005) than control subjects. In the severe COPD group, the degree of systemic arterial desaturation after Valsalva in patients with PFO was significantly greater than in patients without PFO (Sao2 change: -3.1% +/- 1.4% vs -1.5% +/- 0. 5%; P <.05). Significant systemic arterial oxygen desaturation was observed after Valsalva in 45% of patients with interatrial PFO shunting and severe COPD. This significantly correlated with the degree of pulmonary hypertension (r = 0.6; P <.05). We conclude (1) that patients with severe COPD have an increased prevalence of PFO and (2) that approximately one half of subjects with severe COPD and PFO demonstrate statistically significant systemic arterial oxygen desaturation after the Valsalva maneuver. PMID- 9950969 TI - Estimation of left ventricular end-diastolic pressure with the difference in pulmonary venous and mitral A durations is limited when mitral E and A waves are overlapped. AB - Previous studies showed that difference in pulmonary venous and mitral A-wave durations can be used for the estimation of left ventricular end-diastolic pressure, which is based on the assumption that the pulmonary venous A wave and mitral A wave start with the beginning of left atrial contraction. It is also assumed that the mitral A wave ends with the end of left atrial contraction. These assumptions may not be correct if left atrial contraction occurs before the early left ventricular filling is completed. Adequate Doppler mitral inflow and pulmonary venous flow signals were obtained simultaneously with left ventricular pressures at the cardiac catheterization laboratory in 50 patients who showed separated E and A waves in mitral inflow. After heart rate was increased by right atrial pacing to make the mitral E and A waves overlap, Doppler and hemodynamic measurements were repeated. When E and A waves are separated, pulmonary A-wave duration exceeding mitral A-wave duration has a sensitivity of 67% and specificity of 85% in the prediction of elevated left ventricular end-diastolic pressure (>/=20 mm Hg), whereas the pulmonary A wave ending later than mitral A wave has a sensitivity of 83% and a specificity of 45%. When the mitral E and A waves are overlapped, the pulmonary A wave ending later than mitral A wave is better for the prediction of elevated left ventricular end-diastolic pressure (sensitivity 55%, specificity 75%) than pulmonary A-wave duration exceeding mitral A-wave duration (sensitivity 9%, specificity 96%). However, overall, both methods are limited for clinical use. PMID- 9950970 TI - Abnormal global left ventricular relaxation occurs early during the development of pharmacologically induced ischemia. AB - In animal and human models, left ventricular (LV) diastolic function has been observed to be highly sensitive to myocardial ischemia. The response of LV diastolic parameters to pharmacologically induced ischemia, however, has not been characterized and might be important in the interpretation of dobutamine stress echocardiography. Eight mongrel dogs, in which were inserted a high-fidelity micromanometer LV catheter, coronary sinus sampling catheter, and ultrasonic coronary artery flow probe, underwent intravenous dobutamine infusion at escalating doses both before (control protocol) and after (ischemia protocol) creation of left anterior descending coronary artery stenosis with a hydraulic cuff occluder adjusted to maintain resting coronary artery flow but attenuate reactive hyperemia. At each dobutamine dose, epicardial short-axis 2-dimensional echocardiographic images and hemodynamic measurements were obtained. LV diastolic function was examined by calculation of peak (-)dP/dt and the time constant of isovolumic relaxation (tau). The dobutamine infusion protocol was terminated on the earliest recognition of an anterior wall motion abnormality. Peak (+)dP/dt normalized for developed isovolumetric pressure was calculated as a relatively load-independent index of global LV contractile function. Dobutamine infusion with and without ischemia resulted in comparable changes in heart rate and (+)dP/dt/IP, with no change in LV end-diastolic or -systolic pressure. The magnitude of peak (-)dP/dt increased less during the ischemia (1231 +/- 109 to 1791 +/- 200 mm Hg/sec) versus the control (1390 +/- 154 to 2432 +/- 320 mm Hg/sec) protocol (P <.05). Similarly, the observed decrease in tau was less during the ischemia (53 +/- 3 to 38 +/- 4 msec) than the control (51 +/- 5 to 23 +/- 3 msec) protocol, corresponding to a slower rate of relaxation (P <.05). In addition, the smaller decrease in tau was observed at the dobutamine dose before the dose at which an echocardiographic wall motion abnormality was first recognized. Dobutamine-induced ischemia is associated with abnormal LV diastolic function. In addition, these abnormalities seem to occur early in the development of ischemia. These observations extend to pharmacologically induced ischemia prior findings from other models of ischemia, suggesting the high sensitivity of LV diastolic function to the development of myocardial ischemia. PMID- 9950971 TI - Left ventricular systolic wall motion velocities along the long and short axes measured by pulsed tissue Doppler imaging in patients with atrial fibrillation. AB - Pulsed tissue Doppler imaging was performed to measure systolic left ventricular (LV) posterior wall motion velocity along the long and short axes and to evaluate the relationships between the systolic variables and the maximum first derivative (peak dP/dt) of the LV pressure curve and the 2 preceding R-R intervals in 39 patients with atrial fibrillation (AF). The study group consisted of 22 patients with AF only, 17 patients with dilated or ischemic cardiomyopathy and AF, and 25 healthy control subjects in sinus rhythm. The systolic component of the LV posterior wall motion velocity was divided into the first (Sw1) and second (Sw2 ) systolic waves. The peak Sw1 along the long axis was greater than either that along the short axis or the peak Sw2s along the long and short axes in the control and AF-only groups. The peak Sw1 along the long axis was lower in the AF only group than in the control group, and those along the short and long axes were lower in the dilated AF group than in the other groups. The peak Sw1 almost coincided with the peak dP/dt. The peak Sw1 along the long axis correlated closely with the peak dP/dt, and the ratio of the preceding R-R interval to the interval before the preceding ("prepreceding") R-R interval in both AF groups, particularly in the dilated AF group, and the slopes of their relationships were steeper in the dilated AF group than in the AF-only group. The peak Sw2 along the short axis was greater than that along the long axis in the control and AF-only groups. The peak Sw2 along the long axis was lower in the AF-only group than in the control group, and those along the short and long axes were lower in the dilated AF group than in the other groups. The peak dP/dt was lower and the LV end-diastolic pressure was higher in the dilated AF group than in the other groups. In conclusion, peak Sw1 along the long axis is useful for the evaluation of isovolumic myocardial LV contractility, and the interval-force relation and the Frank-Starling mechanism are important factors of beat-to-beat variability in systolic LV function in patients with AF. PMID- 9950972 TI - Color M-mode Doppler flow propagation velocity is a relatively preload independent index of left ventricular filling. AB - Standard Doppler indexes of transmitral filling vary in response to alterations in left ventricular (LV) relaxation or preload. To determine whether color M-mode Doppler flow propagation velocity (vp), a new index of LV relaxation, is affected by preload, we obtained LV volumes, standard Doppler filling indexes, and vp in 20 patients at baseline, during Trendelenburg's position, inverse Trendelenburg's position, and after inhalation of amyl nitrite. LV end-diastolic volume decreased from 111 +/- 41 mL at baseline and 116 +/- 43 mL during Trendelenburg's position, to 104 +/- 40 during inverse Trendelenburg's maneuver and 92 +/- 33 mL after inhalation of amyl nitrite (P <.0001). Peak early filling velocity decreased from 79 +/- 19 cm/s and 90 +/- 20 cm/s to 73 +/- 22 cm/s and 64 +/- 20 cm/s, respectively (P < 0.0001). In contrast, no significant changes were found in vp (48 +/- 24 and 50 +/- 26 cm/s vs 48 +/- 25 and 48 +/- 25 cm/s). We conclude that vp is not affected significantly by preload. Thus vp may provide a more reliable and independent assessment of LV relaxation. PMID- 9950973 TI - Quantitative assessment of chronic aortic regurgitation with 3-dimensional echocardiographic reconstruction: comparison with electromagnetic flowmeter measurements. AB - Two-dimensional echocardiography and color Doppler are useful in the qualitative assessment of aortic regurgitation. However, color Doppler planar methods are not accurate in quantifying regurgitant flow, in part because of the complex geometry of aortic regurgitant flow events. Three-dimensional echocardiographic reconstruction is a new technique that provides dynamic 3-dimensional images of intracardiac color flow jets. We sought to determine whether the measurement of aortic regurgitant jet volume by 3-dimensional echocardiography correlated with the true regurgitant volume, measured by electromagnetic flowmeter in vivo, to accurately reflect the severity of aortic regurgitation. We performed volume rendered 3-dimensional echocardiography in 6 sheep with surgically induced chronic eccentric aortic regurgitation. We obtained a total of 22 aortic regurgitation states by altering loading conditions. Instantaneous regurgitant flow rates were obtained by aortic and pulmonary electromagnetic flowmeters. The maximum aortic regurgitant jet volume by 3-dimensional echocardiography and the maximum jet area by 2-dimensional echocardiography were measured and compared with electromagnetic flowmeter data. By electromagnetic flowmeter, aortic regurgitant flow rate varied from 0.14 to 3.1 L/min (mean 1. 25 +/- 0.78); aortic regurgitant stroke volume varied from 1 to 34 mL/beat (mean 12 +/- 8), and regurgitant fraction varied from 3% to 42% (mean 25% +/- 12%). The maximum jet volume by 3-dimensional echocardiography correlated very well with the aortic regurgitant stroke volume (r = 0.92; P <.0001), with the mean regurgitant flow rate (r = 0.87; P <.0001), and with the regurgitant fraction (r = 0. 87; P <.0001) derived from electromagnetic flowmeter. Both intraobserver and interobserver variability on the measurement of the jet volume by 3-dimensional echocardiography were excellent (r = 0.98; P <.0001 and r = 0.90; P <.001, respectively). The maximum jet area by 2-dimensional echocardiography did not correlate with the aortic regurgitant stroke volume (r = 0.41; P = not significant) and related poorly with the regurgitant fraction (r = 0.52; P <.05) by electromagnetic flowmeter. Dynamic 3-dimensional echocardiography can allow better determination of the geometry of the aortic regurgitant jet and may assist of quantifying the severity of aortic regurgitation. PMID- 9950974 TI - Doppler echocardiographic features of coronary artery fistula: report of 8 cases. AB - Coronary artery fistula is a rare congenital anomaly in which the involved coronary artery empties into a cardiac chamber, pulmonary artery, or other structure. Its diagnosis can be made noninvasively by finding a dilated coronary artery by 2-dimensional (2D) echocardiography, and its drainage can be detected by color flow mapping. We describe features of coronary artery fistulas in 8 patients whose condition was prospectively diagnosed by Doppler echocardiography with color flow mapping. The right coronary artery was involved in 4 cases and the left coronary artery in 4. Four fistulas drained to the right ventricle, 2 to the right atrium, and 2 to the pulmonary artery. In 1 patient who had left and right coronary fistulas to the pulmonary artery, only the first was diagnosed noninvasively. The diagnosis of coronary fistulas can usually be made by 2D echocardiography with color flow mapping. However, fistulas to the pulmonary artery may be more difficult to detect by 2D echocardiography because the coronary artery may be of normal size and the shunt small. PMID- 9950975 TI - Utility of contrast echocardiography in the diagnosis of aortic dissection. AB - Determination of ascending aortic involvement in aortic dissection has significant implications in prognosis, immediate surgical referral, and surgical approach. We report 2 cases of the use of an echo contrast agent in enhancing the diagnostic capability of transesophageal echocardiography in suspected ascending aortic dissection. Contrast echocardiography eliminated the linear artifacts often confused with true dissection flaps and allowed easy identification of the presence of true and false lumina. PMID- 9950976 TI - Tetralogy of Fallot with absent pulmonary valve and total anomalous pulmonary venous connection. AB - It has been shown that congenital absence of the pulmonary valve rarely occurs by itself but tends to be associated with other heart defects, especially tetralogy of Fallot. Other malformations and other complex cardiac malformations also have been described in patients with absent pulmonary valve. In this report we describe the findings of a patient with this combination of cardiac defects who survived spontaneously to adulthood. PMID- 9950978 TI - The vascular fellowship: a critical review. PMID- 9950977 TI - Clinical relevance of subclinical tricuspid regurgitation after orthotopic cardiac transplantation. PMID- 9950979 TI - Progression of asymptomatic carotid stenosis: a natural history study in 1004 patients. AB - PURPOSE: The purpose of this study was to delineate the natural history of the progression of asymptomatic carotid stenosis. METHODS: In a 10-year period, 1701 carotid arteries in 1004 patients who were asymptomatic were studied with serial duplex scans (mean follow-up period, 28 months; mean number of scans, 2.9/patient). At each visit, stenoses of the internal carotid artery (ICA) and the external carotid artery (ECA) were categorized as none (0 to 14%), mild (15% to 49%), moderate (50% to 79%), severe (80% to 99%), preocclusive, or occluded. Progression was defined as an increase in ICA stenosis to >/=50% for carotid arteries with a baseline of <50% or as an increase to a higher category of stenosis if the baseline stenosis was >/=50%. The Cox proportional hazards model was used for data analysis. RESULTS: The risk of progression of ICA stenosis increased steadily with time (annualized risk of progression, 9.3%). With multivariate modeling, the four most important variables that affected the progression (P <.02) were baseline ipsilateral ICA stenosis >/=50% (relative risk [RR], 3.34), baseline ipsilateral ECA stenosis >/=50% (RR, 1.51), baseline contralateral ICA stenosis >/=50% (RR, 1.41), and systolic pressure more than 160 mm Hg (RR, 1. 37). Ipsilateral neurologic ischemic events (stroke/transient ischemic attack) occurred in association with 14.0% of the carotid arteries that were studied. The progression of ICA stenosis correlated with these events (P <.001), but baseline ICA stenosis was not a significant predictor. CONCLUSION: In contrast to recently published studies, we found that the risk of progression of carotid stenosis is substantial and increases steadily with time. Baseline ICA stenosis was the most important predictor of the progression, but baseline ECA stenosis also was identified as an important independent predictor. Contralateral ICA stenosis and systolic hypertension were additional significant predictors. We found further that the progression of ICA stenosis correlated with ischemic neurologic events but not baseline stenosis. The data provide justification for the use of serial duplex scans to follow carotid stenosis and suggest that different follow-up intervals may be appropriate for different patient subgroups. PMID- 9950980 TI - Outcome of moderate carotid artery stenosis in patients who are asymptomatic. AB - PURPOSE: The incidence rate of disease progression and stroke after the diagnosis of a moderate (50% to 79%) carotid stenosis was determined by means of color-flow duplex scanning. METHODS: During a 4-year period, 344 male veterans with moderate internal carotid artery stenoses, on one or both sides, were examined at regular intervals for a mean period of 25 months. Carotid color-flow scans were obtained semiannually. Clinical follow-up was performed to determine the incidence rate of amaurosis fugax, transient ischemic attacks, nonhemispheric symptoms, and strokes. RESULTS: New neurologic symptoms developed in 75 patients (21.8%). Fifty one (14.8%) had ipsilateral symptoms during follow-up: 18 amaurosis fugax (5.2%), 14 transient ischemic attacks (4%), 5 nonhemispheric symptoms (1.4%), and 14 strokes (4%). Twenty-four patients (6.9%) had contralateral symptoms: 20 strokes (5.8%) and 4 transient ischemic attacks (1.2%). Life-table analysis showed that the annual rate of ipsilateral neurologic events was 8.1%, and the annual rate of stroke was 2.1%. Seventy-five patients (22%) died in the follow-up period. Disease progression to 80% to 99% stenosis or occlusion occurred in 71 of 458 vessels (15.5%). The internal carotid arteries that showed evidence of disease progression had a significantly higher initial peak systolic velocity (251 vs 190 cm/s; P <.0001) and end diastolic velocity (74 vs 52 cm/s; P < 0.0001). Black patients and patients with ischemic heart disease were at a higher risk for disease progression. We could not identify any atherosclerotic risk factors that reliably predicted patients in whom future ipsilateral neurologic symptoms were more likely to develop. However, there was an increased risk of stroke associated with progression of disease. CONCLUSION: Patients who are asymptomatic and who have moderate carotid stenoses are at significant risk for neurologic symptoms and death, but have a relatively low incidence rate of ipsilateral events. The initial flow characteristics in the stenotic vessel are predictive of future disease progression, but they are not helpful in identifying patients in whom symptoms will develop. PMID- 9950981 TI - Carotid restenosis: operative and endovascular management. AB - PURPOSE: Surgical management of carotid restenosis (CR) after carotid endarterectomy (CEA) has been associated with a higher perioperative complication rate than that of primary CEA. We recently used carotid angioplasty-stenting (CAS) as an alternative to operative management in patients who had undergone CEA within three years, and we retrospectively compared these results with those of operative management of CR and the overall results of CEA. METHODS: CEA was performed on 1065 adult patients (58% symptomatic, 42% asymptomatic), 62% of whom were men (n = 660) and 38% of whom were women (n = 405), from 1989 to 1997. Before our initiation of a program of CAS, 16 operative procedures (1.9% of CEAs) were performed for CR in 14 adult patients (7 women and 7 men). During the last 20 months, CAS was used in the management of 17 CRs (16 patients; 9 women and 7 men). RESULTS: The 30-day stroke morbidity-death rate for all CEAs (n = 1065) was 1.4%; 11 strokes (1. 0%) occurred (4 major strokes with disability and 7 strokes with minor or no disability), and 4 deaths (0.4%) occurred (2 deaths caused by myocardial infarction, 1 caused by intracranial hemorrhage, and 1 caused by stroke). Operative management of CR (n = 16) included patch angioplasty in 12 cases (autologous vein patches in 10 cases and synthetic patches in 2 cases), whereas interposition grafting was used in 4 cases (saphenous vein in 3 instances and synthetic [polytetrafluoroethylene] in one case). No strokes or deaths were observed. One recurrent laryngeal nerve palsy occurred (6.2%). Among the 16 patients undergoing 17 CAS procedures, the technical procedures were accomplished in all patients. No strokes or deaths occurred. No recurrent restenoses (50% or greater) have been identified within or adjacent to the CAS procedures. CONCLUSION: CR caused by myointimal hyperplasia can be managed by operative techniques or CAS with comparable periprocedural complications. Although long term follow-up will be required to determine the incidence of recurrent restenosis, CAS may become the preferred procedure in these cases. A randomized clinical trial ultimately will be necessary to determine the role of CAS, as compared with that of operative management. PMID- 9950982 TI - Cervical reconstruction of the supra-aortic trunks: a 16-year experience. AB - PURPOSE: The purpose of this study was to review 182 consecutive cervical reconstructions of supra-aortic trunks, which were performed over a 16-year period. METHODS: A total of 182 innominate, common carotid, or subclavian arteries were reconstructed with a cervical approach in 173 patients aged 23 days to 83 years. Indications included hemispheric (n = 79), vertebrobasilar (n = 56), upper extremity (24), and internal mammary/cardiac ischemia (n = 5), asymptomatic severe common carotid disease (n = 33), or other (n = 3). Primary atherosclerotic innominate (n = 6), common carotid (n = 84), and subclavian (n = 66) lesions underwent reconstruction. Thirty-one operations were performed for multiple trunk involvement, recurrent disease, arteritis, infection, dissection, coarctation, or aneurysm. There were 122 bypass grafting procedures (98 ipsilateral, 24 contralateral) and 60 arterial transpositions. RESULTS: One death (0.5%) and 7 nonfatal strokes (3.8%) occurred, none in patients who were asymptomatic. Perioperative morbidity included four asymptomatic occlusions (2%), 6 myocardial infarctions (3%), 10 pulmonary complications (5%), and 2 graft infections (1%). Follow-up periods ranged from 1 to 190 months (mean, 53 +/- 5 months). Nineteen patients (10%) were lost to follow-up. Fifty-seven late deaths occurred, most from cardiac causes. Seven reconstructions necessitated late revision. The cumulative primary patency rate at 5 and 10 years was 91% +/- 2% and 82% +/- 5%, respectively. The survival rate at 5 years was 72% +/- 4% and at 10 years was 41% +/- 6%. The stroke-free survival rate was 92% +/- 2% at 5 years and 84% +/- 2% at 10 years. CONCLUSION: Cervical reconstruction of symptomatic and asymptomatic supra-aortic trunk lesions carries acceptable death and stroke rates and provides a long-term patient benefit. This should be the preferred approach for asymptomatic lesions and for patients with significant comorbidity because it carries less morbidity than direct transmediastinal aortic-based reconstruction. PMID- 9950983 TI - Descending thoracic aorta to iliofemoral artery bypass grafting: a role for primary revascularization for aortoiliac occlusive disease? AB - PURPOSE: Bypass grafts that originate from the descending thoracic aorta to the iliac or femoral arteries are well described but are not commonly used as primary procedures, and the long-term results remain unknown. A 15-year experience with 50 descending thoracic aorta to iliofemoral artery bypass grafts for aortoiliac occlusive disease is the basis of this report. METHODS: From January 1983 to December 1997, patients who underwent bypass grafting procedures from the descending thoracic aorta to the iliac or femoral arteries were identified. Surgical indications, morbidity and mortality rates, primary and secondary patency rates, limb salvage rates, and survival rates were determined. RESULTS: Fifty descending thoracic aorta to iliofemoral artery bypass grafting procedures were performed 24 (48%) for severe claudication, 22 (44%) for rest pain, and 4 (8%) for ischemic ulceration. A primary procedure was performed in 31 patients (62%) for complete occlusion (21 patients) and severe atherosclerotic disease (10 patients) of the infrarenal aorta. The indications for 19 secondary revascularizations (38%) were prior aortic or extra-anatomic graft failure in 17 cases and aortic graft infection in 2 cases. The follow-up periods ranged from 1 to 150 months (mean, 39 months). The cumulative life-table 5-year primary patency, secondary patency, limb salvage, and survival rates were 79%, 84%, 93%, and 67%, respectively. An improved patency trend was observed for patients who underwent operation for severe claudication as compared with limb-threatening ischemia (92% and 69%; P =.07). However, there was no difference between primary and secondary operations in primary patency rates (81% and 79%; P = NS) or survival rates (72% and 62%; P = NS). CONCLUSION: Descending thoracic aorta to iliofemoral artery bypass grafting has excellent overall long-term results. These results support its more liberal use for primary revascularization, especially for patients with severe atherosclerotic disease or complete occlusion of the infrarenal aorta. PMID- 9950984 TI - Infrainguinal arterial reconstruction for claudication: is it worth the risk? An analysis of 409 procedures. AB - PURPOSE: Infrainguinal reconstruction traditionally has been reserved for patients with limb-threatening ischemia. Surgery for debilitating claudication, however, has been discouraged as a result of the perceived fear of bypass graft failure, limb loss, and significant perioperative complications that may be worse than the natural history of the disease. In this study, the results of infrainguinal reconstructions for claudication performed during the past 10 years were evaluated for bypass graft patency, limb loss, and long-term survival rates. METHODS: Data were collected and reviewed from the vascular registry, the office charts, and the hospital records for patients who underwent infrainguinal bypass grafting for claudication. RESULTS: From 1987 to 1997, 409 infrainguinal reconstructions were performed for claudication (9% of all infrainguinal reconstructions in our unit). The patient population had the following demographics: 73% men, 28% with diabetes, 54% smokers, and an average age of 64 years (range, 24 to 91 years). Inflow was from the following arteries: iliac artery/graft, 10%; common femoral artery, 52%; superficial femoral artery, 19%; profunda femoris artery, 16%; and popliteal artery, 2%. The outflow vessels were the following arteries: 165 above-knee popliteal arteries (40%), 150 below-knee popliteal arteries (37%), and 94 tibial vessels (23%). The operative mortality rate was 0%, and one limb was lost in the series from distal embolization. The primary patency rates were 62%, 77%, and 86% for above-knee popliteal artery, below-knee popliteal artery, and tibial vessel reconstructions at 4 years, and the secondary patency rates were 64%, 81%, and 90%, respectively. Cumulative patient survival rates were 93% and 80% at 4 and 6 years as compared with 65% and 52%, respectively, for infrainguinal reconstructions performed for limb salvage. CONCLUSION: Infrainguinal arterial reconstruction for disabling claudication is a safe and durable procedure in selected patients. These data indicate that concern for limb loss, death, and limited life span of the patients with this disease may not be warranted. PMID- 9950985 TI - Duplex scanning alone is not sufficient imaging before secondary procedures after lower extremity reversed vein bypass graft. AB - PURPOSE: Duplex surveillance of lower extremity reversed vein bypass grafts (LERVG) is a means of identifying patients at risk for occlusion. The perceived accuracy of duplex scan as a means of identifying stenoses has led many surgeons to perform graft revision on the basis of duplex scan alone. This may result in missing additional lesions that are threatening patency. To assess the role of duplex scan as the sole imaging method before revision of LERVGs, we reviewed consecutive patients undergoing revisions who underwent preoperative arteriography after identification of duplex scan abnormalities. METHODS: Duplex scan results, operative reports, and preoperative arteriograms for patients undergoing LERVG revision from January 1990 to December 1997 were reviewed. A standard duplex scan surveillance protocol was followed, and attempts were made to survey the entire graft, including inflow and outflow. Duplex scan results were compared with the results of preoperative arteriograms and the operation performed to determine if all significant lesions were identified by means of duplex scan alone. RESULTS: Two hundred five LERVG revisions were performed. The 5-year assisted primary patency rate was 91%. In 119 cases (58%), arteriography did not contribute significantly to duplex scan findings. Arteriography significantly contributed to operative planning in 86 cases (42%). In 38 cases (19%), only a low-flow state was identified by means of duplex scan, and a correctable stenosis was identified by means of arteriography. In 48 cases (23%), additional significant lesions corrected at operation were identified by means of arteriography. These included 26 inflow, 16 graft, and 8 outflow lesions. Arteriography was most useful as a means of determining the revision procedure performed when there were inflow lesions (P <.05) or when the proximal anastomosis was to the profunda or superficial femoral arteries (P <.05). All frequently performed bypass graft configurations had some discrepancy between arteriographic and duplex scan findings. CONCLUSION: Available data do not permit prediction of which LERVG are immune from missed lesions in a duplex scan surveillance protocol. This suggests to us that arteriography is mandatory before LERVG revisions. PMID- 9950986 TI - Venous morbidity after superficial femoral-popliteal vein harvest. AB - PURPOSE: The superficial femoral-popliteal vein (SFPV) is a reliable conduit for aortoiliac, infrainguinal, and venous reconstructions. In this prospective study, we characterized the anatomic and physiologic changes in SFPV harvest limbs and their relationship to the development of late venous complications. METHODS: Since 1990, we have studied 61 patients after harvest of 86 SFPVs at 6-month intervals with clinical examinations, lower-extremity venous duplex, and venous function tests. The CEAP system was used as a means of categorizing clinical changes. RESULTS: Mean (+/- SEM) follow-up was 37 +/- 3 months. Less than one third of harvest limbs had edema without skin changes (C3). No patient had major chronic venous changes (C4 to C6) or venous claudication. There were no significant differences in limb measurements between harvest and non-harvest limbs, except in a subgroup of patients with unilateral harvest in which there was a small but significant (P =.046) increase in harvest limb thigh and calf circumference, compared with the opposite non-harvest limb. These clinical results were not affected by the presence or absence of an intact greater saphenous vein (GSV). Large, direct collaterals (4 to 6 mm in diameter) between the popliteal vein stump and profunda femoris vein (PFV) were seen by means of duplex ultrasonography in 29 harvest limbs (34%). The remainder appeared to have smaller, less direct collaterals to the PFV. Mild venous reflux with rapid cuff deflation was present at the popliteal or posterior tibial vein in nine of 79 harvest limbs (11%). Six of these nine limbs (67%) with reflux were clinical class C3, compared with only 19 of the 70 limbs without reflux (27%; P =.02). Ambulatory venous pressure (AVP) with exercise was significantly increased in harvest limbs (60 +/- 4.7 mm Hg), compared with non-harvest limbs (47.8 +/- 5.2 mm Hg; P =.049). The AVP recovery time of harvest limbs (14.0 +/- 1.0 seconds) was reduced, compared with non-harvest limbs (23.5 +/- 4.5 seconds; P =.02). AVPs (exercise) remained stable or decreased in six of 10 harvest limbs measured serially. Venous refill time in harvest limbs (15.1 +/- 1.1 seconds) was shortened, compared with non-harvest limbs (22.3 +/- 2. 1 seconds)(P =.002). Venous outflow obstruction measured by means of plethysmography was present in 93% of harvest limbs, compared with 36% of non-harvest limbs (P =.001). CONCLUSION: SFPV harvest results in minimal mid-term to late-term lower-extremity venous morbidity despite outflow obstruction. The most likely mechanisms preserving clinical status include the low incidence of mild reflux, the presence of collateral venous channels, and the lack of progression in abnormal harvest limb physiology. The absence of the ipsilateral GSV does not adversely affect clinical outcome. PMID- 9950987 TI - AneuRx stent graft versus open surgical repair of abdominal aortic aneurysms: multicenter prospective clinical trial. AB - The results of a prospective, nonrandomized, multicenter clinical trial that compared endovascular stent graft exclusion of abdominal aortic aneurysms with open surgical repair are presented. During an 18-month period, 250 patients with infrarenal aneurysms underwent treatment at 12 study sites-190 patients underwent endovascular repair using the Medtronic AneuRx stent graft (Sunnyvale, Calif), and 60 underwent open surgical repair. There was no significant difference in operative mortality rates between the groups. The patients who underwent stent grafting had significant reductions in blood loss, time to extubation, and days in the intensive care unit and in the hospital, with an earlier return to function. The major morbidity rate was reduced from 23% in the surgery group to 12% (P <. 05) in the stent graft group. There was no difference in the combined morbidity/mortality rates between the two groups. Primary technical success at the time of discharge for the patients with stent grafts was 77%, largely as a result of a 21% endoleak rate. At 1 month, the endoleak rate had decreased to 9%. There was no difference in the primary or secondary procedure success rates at 30 days between the surgery and stent graft groups. The primary graft patency rate at 6 months was 98% in the surgery group and 97% in the stent graft group. The aneurysm exclusion rate at 1 month and 6 months was 100% in patients who underwent surgery and 91% in patients who underwent stent grafting. Stent graft migration occurred in three patients and resulted in late endoleaks; each endoleak was corrected by means of endovascular placement of a stent graft extender cuff. There have been no aneurysm ruptures and no surgical conversions to open repair in the stent graft group. Stent graft repair compares favorably with open surgical repair, with a reduced morbidity rate, shortened hospital stays, and satisfactory short term outcomes. PMID- 9950988 TI - Immediate and late explantation of endovascular aortic grafts: the endovascular technologies experience. AB - PURPOSE: The morbidity and clinical outcome of the failure to successfully repair an abdominal aortic aneurysm with Endovascular Technologies (EVT) grafts, resulting in explantation of the device, was assessed. METHODS: The records of all patients worldwide undergoing attempted endovascular repair with EVT devices from February 1993 to October 1997 were retrospectively reviewed. Of 669 patients, 19 (3%) were converted to open procedure with immediate explantation during the initial attempt at endovascular repair, and 27 patients (4%) required explantation at a later date, ranging from 1 day to 40 months. The incidence, morbidity, mortality, and effect on clinical outcome were evaluated. RESULTS: Causes of immediate conversion with explantation were: inaccurate deployment of the proximal or distal attachment systems (11 of 19; 58%); twists in the system (3 of 19; 16%); mechanism malfunction during deployment (4 of 19; 21%); and an aortic tear (1 of 19; 5%). Among the 27 patients undergoing late explantation, 20 (74%) did so because of persistent endoleaks. Three cases (11%) were performed because of aneurysm rupture, three (11%) because of graft occlusion, one because of aortic dissection (4%), and one (4%) because of graft migration into the aneurysm sac. The overall perioperative mortality rate was 11% (2 of 19) for immediate explantation and 7% (2 of 27) for late explantation. The average length of-stay was 11 days for immediate explantation and 14 days for late explantation (NS). Complications included myocardial infarction (4%), pulmonary insufficiency (13%), wound infection (4%), and permanent renal failure (2%). There were no significant differences in the incidence rates of these complications between immediate and late explants. No cases of limb loss occurred. Median American Society of Anesthetists (ASA) classification was 3, and there was no correlation between ASA classification and mortality rate. Average operating time was 374 minutes for immediate explantation (including the time for the failed endovascular procedure) and 185 minutes for late explantation. CONCLUSION: Immediate and late explantation are infrequent events, occurring in 3% and 4%, respectively, of attempted EVT endovascular aortic stent placements. The mortality rate was higher for both immediate (11%; P <.05) and late (7%; NS) explantation when compared with the mortality rate of all patients undergoing EVT aortic endograft placement (1.5%). There does not appear to be increased long term morbidity among patients undergoing successful explantation. Early recognition of the need to convert to open procedure, device improvement, and increased operator experience should continue to minimize the incidence of immediate and late explantation and their associated complications. PMID- 9950989 TI - Interferon gamma up-regulates a novel protein in vascular smooth muscle cells. AB - PURPOSE: By means of the technique of messenger RNA (mRNA) differential display, we previously isolated a partial DNA clone found to be down-regulated at the polytetrafluoroethylene (PTFE) hyperplastic arterial anastomosis compared with the normal artery. The partial DNA gene sequence was found to be homologous with interferon gamma up-regulated protein (IGUP) first found in human psoriatic keratinocytes. We cloned the entire IGUP gene from human vascular smooth muscle cells (VSMCs) to determine its regulation by gamma interferon (gamma-IFN) and other cytokines in cultured human VSMCs. METHODS: By means of polymerase chain reaction, the IGUP gene was amplified from a QUICK-Clone complementary DNA human aorta kit using 5' and 3' oligonucleotide primers to the known IGUP sequence. Immunohistocytochemistry studies compared normal artery and distal anastomotic IH. Human VSMCs were stimulated with 1000 U/mL of gamma-IFN, 5 ng/mL of platelet derived growth factor BB (PDGF-BB), 3. 2 ng/mL basic fibroblast growth factor, 3.3 ng/mL transforming growth factor beta(TGF-beta), 10 ng/mL of vascular endothelial growth factor, and 10% fetal bovine serum (FBS) for zero, 24, 48 and 72 hours. Western blot analysis of lysates of the stimulated VSMCs was performed to determine up-regulation of IGUP. RESULTS: DNA sequencing confirmed the cloning of the entire coding region of the IGUP gene with 100% homology to the known IGUP DNA sequence. There was strong expression of IGUP in quiescent VSMCs and marked reduction of expression of IGUP in proliferating smooth muscle cells. gamma-IFN was the only cytokine, of the cytokines evaluated, to up-regulate production of IGUP in VSMCs. CONCLUSION: IGUP is a novel protein in VSMCs found to be down regulated in areas of anastomotic IH, as compared with a normal artery. We have now shown IGUP to be up-regulated only by gamma-IFN in human VSMCs. IGUP may, therefore, be the intermediary for the known gamma-IFN inhibition of human VSMC proliferation. PMID- 9950990 TI - The small heat shock-related protein-20 is an actin-associated protein. AB - PURPOSE: The activation of cyclic nucleotide-dependent signaling pathways in vascular smooth muscle is important for the prevention of vein graft spasm and neointimal hyperplasia. Cyclic nucleotide-dependent relaxation is associated with an increase in the phosphorylation of a small heat shock-related protein (HSP20). In this investigation, we examined the mechanisms by which HSP20 may modulate relaxation. METHODS: The relaxation responses of the bovine carotid artery smooth muscles were determined in a muscle bath. HSP20 phosphorylation was quantitated with isoelectric-focusing immunoblots. The association with actin was determined with coimmunoprecipitation and cosedimentation. Molecular sieving columns were used to examine the macromolecular associations of HSP20. RESULTS: The activation of cyclic nucleotide signaling pathways leads to the complete relaxation of carotid smooth muscle. This relaxation response is associated with an increase in the phosphorylation of HSP20. Actin coimmunoprecipitated with HSP20, and the association of actin with recombinant HSP20 in vitro was phosphorylation-state dependent. Finally, HSP20 exists in large (>100 kDa) aggregates, which dissociate with the activation of cyclic nucleotide signaling pathways. CONCLUSION: These data support a role of HSP20 phosphorylation in mediating smooth muscle relaxation, possibly via a direct interaction of large aggregates of HSP20 with the contractile elements. PMID- 9950991 TI - Alterations in wall tension and shear stress modulate tyrosine kinase signaling and wall remodeling in experimental vein grafts. AB - PURPOSE: Hemodynamic alterations have been implicated as major stimuli for the development of intimal hyperplasia in vein grafts that are implanted in the arterial circulation. Tyrosine kinase is known to mediate cell signaling. However, its role with in vivo mechanotransduction is not yet well defined. We used a novel bioprosthetic collagen tube to provide an external support to vein grafts and examined the subsequent changes in hemodynamics, tyrosine kinase signaling, wall remodeling, and vasomotor function. METHODS: Carotid interposition bypass grafting was performed with the reversed jugular vein in New Zealand white rabbits. In the experimental group (n = 15), after the completion of the proximal anastomosis, the vein was passed through a 4-mm collagen tube and the distal anastomosis was performed. The tube support was fashioned to completely cover the vein grafts. The control animals (n = 14) had no tube support. After surgery, the blood pressure and flow rate were measured and the wall tension and shear stress were calculated in the vein grafts on day 3 or day 28 (n = 5 per group). Tyrosine phosphorylation was assessed with the Western blot test in vein grafts at day 3 (n = 4 per group). The intimal and medial dimensions of the vein grafts were assessed with videomorphometry on day 28 (n = 5 per group). The cumulative dose response curves of the vein grafts to contractile and relaxant agonists were determined in isometric tension studies on day 28 (n = 5 per group). RESULTS: The use of tube support reduced wall tension 1.7-fold (P <.01) and increased shear stress 4.8-fold (P <.001) without altering the flow rate or blood pressure. The tyrosine kinase activity was reduced 15-fold (P <.001) in the tube-supported vein grafts. The intimal thickness was reduced by 45% in the tube-supported vein grafts as compared with the control grafts (46 +/- 2 mm vs 84 +/- 5 mm, respectively; P <.0001), and the media thickness was reduced by 20% (63 +/- 8 mm vs 79 +/- 4 mm, respectively; P <.05). Isometric tension studies showed preservation of contractile function and modulation of endothelial dependent dysfunctional relaxation in tube-supported vein grafts. CONCLUSION: These results show that reduced wall tension and increased shear stress with an external tube support can effectively modulate the signaling, functional, and hyperplastic responses in vein grafts. We conclude that this simple strategy deserves further study and clinical consideration. PMID- 9950992 TI - Detection of distal emboli in patients with peripheral arterial stenosis before and after iliac angioplasty: a prospective study. AB - PURPOSE: Embolism is believed to be the major cause of end-organ damage after angioplasty and endoluminal procedures. Recently, Doppler ultrasound scanning has been used to detect asymptomatic cerebral emboli. We determined whether asymptomatic embolic signals (ES) could be detected distal to a significant iliac artery stenosis of >60% both before and soon after iliac percutaneous transluminal angioplasty (PTA). METHODS: A 2-MHz Doppler scan probe was used to monitor for ES in the common femoral artery before and after 10 successful iliac artery PTAs and at various standardized times in the following 24 hours. The same protocol was used to study 10 patients in the control group after renal PTA. In addition, a single recording was performed in a second nonoperative control group of 10 patients who had no evidence of peripheral vascular disease. The Doppler scan signals were recorded on tape for a later blinded analysis. RESULTS: In the 24 hours before iliac PTA, asymptomatic ES were detected in four of 10 patients during a 1-hour recording but in no controls (P =.025). After iliac PTA, ES were detected at 30 minutes in nine of 10 iliac subjects but in only one of 10 renal subjects (P =.0003) and at 2 hours in eight of 10 iliac subjects but in only one of 10 renal subjects (P =.001). The occurrence of ES became less frequent, and ES were present at a lower frequency in eight of 10 iliac PTA subjects at 4 hours and in five of 10 at 24 hours but in no renal PTA subjects at these time points. CONCLUSIONS: ES can be detected in the common femoral artery with Doppler ultrasound scanning in patients with iliac artery stenosis both before and soon after iliac PTA despite preangioplasty aspirin and intra-angioplasty heparin therapies. The occurrences of ES were particularly frequent in the 2 hours after PTA. This technique can be used further to study factors that control plaque stability and to evaluate the effect of therapeutic interventions. PMID- 9950993 TI - Diabetes mellitus is the major risk factor for African Americans who undergo peripheral bypass graft operation. AB - OBJECTIVE: African Americans, especially African American women, have a greater risk of lower extremity ischemia that necessitates an infrainguinal bypass graft operation and amputation. Because the prevalence of diabetes mellitus is proportionally greater in this ethnic/racial group, the relative contribution of diabetes was compared with other potential risk factors. METHODS: This study was designed as a retrospective case control study at the University and Veterans Hospitals. In a 5-year period, 764 consecutive patients who required infrainguinal revascularizations were compared with a statewide population that was described by the 1995 Behavior Risk Factor Surveillance System database. The main outcome measure was the requirement for infrainguinal revascularization. RESULTS: Diabetes mellitus was more common among African American women who underwent bypass graft operation (70%; odds ratio [OR], 24.9; 95% confidence interval [CI], 20.3 to 30.4) than African American men (46%; OR, 11.6; 95% CI, 8.9 to 15.2), white women (49%; OR, 15.9; 95% CI, 13.0 to 19.5), or white men (42%; OR, 14.8; 95% CI, 12.5 to 17.4). Overall, bypass graft operation was associated more strongly with diabetes mellitus for all groups (OR, 15.7; 95% CI, 13.5 to 18. 3) than with smoking (OR, 4.5; 95% CI, 3.8 to 5.2) or hypertension (OR, 4.6; 95% CI, 4.0 to 5.3). Life-table analysis revealed limb salvage to be worse at 3 years among African American patients (64% vs 75%; P <.005) despite similar primary and cumulative secondary graft patency rates. CONCLUSION: Diabetes mellitus is the dominant risk factor that contributes to the need for bypass graft operation, especially among African American women. A greater prevalence of diabetes mellitus may account for the higher incidence of tissue necrosis and the increased requirement for distal bypass grafting and may contribute to the reduction in long-term limb salvage that was observed with these women. PMID- 9950994 TI - p53 gene transfer to the injured rat carotid artery decreases neointimal formation. AB - PURPOSE: We studied the effect of adenovirus-mediated p53 gene transfer on the injured rat carotid artery to determine its ability to decrease the formation of neointima. METHODS: In vivo gene transfer was used in isolated segments of balloon-injured rat carotid arteries. Genetically modified adenovirus containing the gene encoding for wild-type p53 (AdWTp53) was applied in three concentrations: 8 x 10(10), 1.6 x 10(10), and 8 x 10(9) pfu/mL. Control rats received either adenovirus null (AdNull), 8 x 10(10) pfu/mL, or Medium-199 solution (vehicle). Expression of p53 was determined 4 days after gene transfer by Western blotting. Neointimal formation was assessed after 14 days by harvesting carotid arteries and determining the intima/media (I/M) ratio based on cross-sectional area measurement. Simultaneously, immunohistochemistry was done to detect the presence of p53 on smooth muscle cell nuclei. RESULTS: P53 expression was confirmed by Western blotting. There was a significant reduction in neointimal formation on all treated animals compared with controls. The highest dose of AdWTp53 (8 x 10(10) pfu/mL) resulted in a near-total arrest of neointimal formation (I/M = 0.09 +/- 0.03, mean +/- SEM) with P <. 0001 versus vehicle (I/M = 2.23 +/- 0.15) or AdNull (I/M = 2.12 +/-. 12). The intermediate dose of AdWTp53 (1.6 x 10(10) pfu/mL) resulted in an I/M value of 1.04 +/- 0.18, with P <.001 versus vehicle and P =.001 versus AdNull. The lowest dose (8 x 10(9) pfu/mL) resulted in an I/M value of 1.12 +/- 0.18, with P <.001 versus vehicle and P <. 002 versus AdNull. The immunohistochemistry was positive for the presence of p53 in rats infected with AdWTp53. CONCLUSIONS: Adenovirus-mediated gene transfer of p53 protein significantly decreases the formation of neointima in the rat carotid injury model. This may represent a potential therapy for restenosis in humans. PMID- 9950995 TI - Attenuation of skeletal muscle ischemia/reperfusion injury by inhibition of tumor necrosis factor. AB - PURPOSE: Tumor necrosis factor alpha (TNF-alpha) has been shown to play a role in pulmonary injury after lower-extremity ischemia/reperfusion (I/R). However, its role in direct skeletal muscle injury is poorly understood. The hypothesis that endogenous TNF production contributes to skeletal muscle injury after hindlimb I/R in rats was tested. METHODS: Juvenile male Sprague-Dawley rats underwent 4 hours of bilateral hindlimb ischemia and 4 hours of reperfusion (IR) or sham operation (SHAM). A subset was treated with a soluble TNF receptor I construct (STNFRI, 10 mg/kg) 1 hour before ischemia (PRE) or at reperfusion (POST). Direct skeletal muscle injury (SMII) and muscle endothelial capillary permeability (MPI) were quantified by means of Tc99 pyrophosphate and I125 albumin uptake. Pulmonary neutrophil infiltration and hepatocellular injury were assessed by means of myeloperoxidase content (MPO) and aspartate aminotransferase (AST) concentrations, respectively. Serum TNF bioactivity was measured with the WEHI bioassay. RESULTS: Hindlimb I/R (IR vs SHAM) resulted in a significant (P <.05) increase in the SMII (0.52 +/- 0.06 vs 0.07 +/- 0.01) and MPI (0.35 +/-.04 vs 0.06 +/- 0.01). Pretreatment with STNFRI (PRE vs IR) significantly ameliorated both SMII (0.30 +/- 0.05 vs 0.52 +/- 0.06) and MPI (0.23 +/- 0.02 vs 0.35 +/- 0.04), whereas treatment at reperfusion (POST vs IR) had no effect. Hindlimb I/R (IR vs SHAM) resulted in both significant pulmonary neutrophil infiltration (MPO 16.4 +/- 1.06 U/g vs 11.3 +/- 1.4 U/g) and hepatocellular injury (AST 286 +/- 45 U/mL vs 108 +/- 30 U/mL), but neither was inhibited by pretreatment with STNFRI before ischemia. Detectable levels of TNF were measured during ischemia in a significantly higher percentage of the IR group compared with SHAM (9 of 12 vs 3 of 12), and the maximal TNF values were also significantly greater (51.1 +/- 12.6 pg/mL vs 5.5 +/- 2.9 pg/mL). No TNF was detected in any treatment group during reperfusion nor after administration of the STNFRI. CONCLUSION: Acute hindlimb IR initiates a systemic TNF response during the ischemic period that is partly responsible for the associated skeletal muscle injury. PMID- 9950997 TI - The distinguished service award medal of the society for vascular surgery: richard Warren's legacy to vascular surgery PMID- 9950996 TI - Mycotic vascular infections of large arteries with Mycobacterium bovis after intravesical bacillus Calmette-Guerin therapy: case report. AB - Disseminated infection after intravesical bacille Calmette-Guerin instillation for bladder cancer is a rare but potential complication. Vascular infection is an additional serious complication but is seldom reported. We present the first report of a small series of patients with vascular infections after intravesical bacille Calmette-Guerin instillation, and we review the related literature. PMID- 9950998 TI - "Variable induction of experimental abdominal aortic aneurysms with different preparations of porcine pancreatic elastase". PMID- 9950999 TI - Regarding "A comparison of carotid angioplasty with stenting versus endarterectomy with regional anesthesia". PMID- 9951000 TI - Regarding "A comparison of carotid angioplasty with stenting versus endarterectomy with regional anesthesia" PMID- 9951001 TI - Regarding "Aortoiliac stent deployment versus surgical reconstruction: analysis of outcome and cost" PMID- 9951002 TI - Regarding "Detection of active cytomegalovirus infection in inflammatory aortic aneurysms with RNA polymerase chain reaction". PMID- 9951003 TI - Regarding "Impact of a critical pathway on postoperative length of stay and outcomes after infrainguinal bypass". PMID- 9951004 TI - Regarding "Aortoiliac stent deployment versus surgical reconstruction: analysis of outcome and cost". PMID- 9951005 TI - [Neurophysiological evaluation of patients with spinocerebellar ataxia type 2]. AB - INTRODUCTION: Type 2 spinocerebellar ataxia (SCA2) is the condition most often described (to date) in patients with hereditary ataxia, its prevalence being 52 per 100,000 persons. OBJECTIVE: In patients with SCA2 neurogenic patterns are identified by means of electrophysiological techniques. PATIENTS AND METHODS: A transverse study was made of 70 persons with SCA2 of different periods of duration and from different regions of the country. The control group was made up of 108 volunteers. Electrophysiological recordings made were: conventional and quantitative electromyography, late F wave and H reflex responses. Multivariate methods with a confidence interval of 95% (alpha = 0.05) were used for statistical analysis. RESULTS: Conventional electromyography showed a pattern of isolated contractions, predominantly in patients who had had the disorder < or = 5 years, classified as Grade I by the authors; in those with a history of > 5 years there was a pattern of very isolated contractions with motor potentials of amplitudes > 10 microV, without denervation, classified as Grade II. The patients with worse clinical condition were concentrated in this latter group. Significant differences were observed between Groups I, II and control and also regarding the late responses of the F wave and H reflex. CONCLUSIONS: For the first time two types of neurogenic patterns of SCA2 have been established to describe alterations which denote participation of the first and second motor neurones. PMID- 9951006 TI - [Procedural learning in aphasic patients]. AB - OBJECTIVE: This study concerned the procedural learning of semantic categorization. PATIENTS AND METHODS: The procedure used was a serial reaction time in an group of aphasic patients. RESULTS: Group of aphasic patients performed slower reaction times with more errors than the controls, but everyone manifested a decreasing reaction time, even during new semantic material categorization. CONCLUSIONS: Our results showed that the semantic categorization could be facilitated by procedural learning. Furthermore, this study suggest that procedural learning of semantic categorisation is at least relatively independent from cerebral structures usually involved a group of aphasic patients. PMID- 9951007 TI - [Tool for the quantitative evaluation of symptoms in defined idiopathic Parkinson's disease]. AB - OBJECTIVE: To determine the reliability of a clinical quantitative instrument for assessing the symptoms of Defined Idiopathic Parkinson Disease (DIPD). PATIENTS AND METHODS: From 148 patients with parkinsonism syndrome, the best 62 EPID cases, according to Calne et al (1992), and Larsen et al (1994) criteria--37 males and 25 females--were selected. RESULTS: The age mean was 68.4 (7.4) year old, the age of onset was 64 (7.2) years, the time of evolution was 4.3 (2.9) years. 98.4% of the sample was in 1 to 3 Hoehn and Yahr clinical state. Right parkinsonism score (RPS) was 8.2 (4.2), and left (LPS) was 6.7 (4.8). Significant differences between right and left tremor, rigidity and dyskinesia scores were found (ji-squared, p < 0.05). Total parkinsonism score (TPS) was 14 (6.9). Several significant and high correlated coefficients were found between most of the scale's components and Hoehn and Yahr clinical state, TPS, and time of evolution (r > 0.40, p < 0.0001). Total 21 items scale Cronbach's alpha coefficient was 0.92. A stepwise multiple regression model showed that rigidity, postural reflex disorder, and micrography were able to predict the Hoehn and Yahr clinical state (81.4%, p < 0.0001). A principal component analysis showed that akinesia explained more than 59% of the instrument variance, while micrography only explained 0.57% of the variance (100 time lesser). CONCLUSION: A reliability structure of the instrument was demonstrated for assessing parkinsonism symptoms in DIPD subjects. PMID- 9951008 TI - [Changes in lymphocyte subsets s and treatment with beta interferon in active multiple sclerosis]. AB - INTRODUCTION: We report that interferon beta decreases CD8 T cells percentage and increases CD4/CD8 cell's rate in vivo in Multiple Sclerosis (MS) patients. PATIENTS AND METHODS: We studied 40 patients (22 women and 18 men) with clinically definite active MS who received IFN beta. Twenty-six were treated with nIFN (9 MU/week) and 14 with rIFN (28 MU/week). All patients except two with secondary progressive forms presented relapsing remitting courses. Mean age and mean age at onset were 36.5 +/- 9 and 27.8 +/- 7 years respectively. Mean EDSS score was 2.96 +/- 1.8. Patients were reviewed at four weeks and every eight weeks and periodical studies of immunity were performed. T cell subpopulations (CD3, CD4, CD8 and NK) were studied byflow cytometry. RESULTS: The evolution of CD8 T cell percentage showed a statistically significant decrease in all blood samples after 20 weeks of treatment with rIFN (24.3 +/- 8 vs 34.7 +/- 5 in the control group) and after 36 weeks for nIFN beta group (25.7 +/- 6 vs 33.0 +/- 4 in the control group). No changes were detected in CD4 T cell subset. The evolution of CD4/CD8 T cell rate showed an increase over the cut-off (2.200) in all blood samples after 20 weeks of treatment with rIFN (2.302 +/- 1.12, 2.332 +/ 0.99 and 2.488 +/- 1.61 for 20, 28 and 36 weeks respectively) and after 52 weeks for nIFN beta group (2.128 +/- 1.07, 2.346 +/- 1.09 and 3.168 +/- 3.87 for 52, 60 and 68 weeks respectively). CONCLUSIONS: Both nIFN and rIFN beta are able in vivo to decrease CD8 percentage of T cells and increase CD4/CD8+ T cell rate. The increase in the rate is produced earlier in the rIFN treated group. PMID- 9951009 TI - [Stroke: a stranger among the people]. AB - INTRODUCTION: Lack of awareness of warning signs of stroke is a factor that contribute to late patient arrival to the emergency department. OBJECTIVE: The goal of this pilot study was to determine the baseline knowledge of stroke among the population (terminology, signs-symptoms, risk factors and attitude) prior to educational campaigns. PATIENTS AND METHODS: A population-based interview using closed-ended questions was conducted by neurologists among 100 users of the Vall d'Hebron's Primary Health Center, randomly sampled. RESULTS: In our population a 9% unknowns totally the disease, of the remainder, 42% has a good knowledge of signs-symptoms and 46% of risk factors. Only 22% of the sample has good global knowledge of the disease. If suffering a stroke this population should seek medical attention through 911 (46.2%) or come directly to the emergency department (50.5%). If symptoms were gone away, transient ischemic attack (TIA), appears a trend to contact primary physicians (59.3%). Respondents aged > 65 years were less likely to recognize symptoms (p = 0.001) and to consider stroke as an emergency. Respondents with an affected relative (50.5%) tend to locate more exactly the disease at the brain (p = 0.05) and to arrive earlier to the emergency department (p = 0.045), than those with non-affected relatives. CONCLUSIONS: Less than a quarter of our population have a good knowledge of the disease. Stroke is considered an emergency unlike TIA. The information about stroke is theoretically associated with early presentation to the emergency department. These results permit a redesign of the questionnaire to conduct a second phase of the study and generalize them for the Spanish population. PMID- 9951010 TI - [Delayed hospitalization of the patient with acute stroke]. AB - INTRODUCTION AND OBJECTIVE: We analyze the main factors influencing the time delay between onset and admission to the hospital in acute stroke. PATIENTS AND METHODS: Consecutive series of 1,344 patients with acute stroke or transient ischemic attack admitted at two reference hospitals of Valencia and included at the same stroke register. Factors assessed were age, sex, vascular risk factors, stroke onset and arrival at hospital, stroke severity and stroke subtype. RESULTS: In 30% of patients the stroke onset time was unknown. 70.7% of patients with acute stroke, and known onset, arrived to the hospital in the first six hours. The median time from onset to admission was: TIA, 2 hours; cerebral infarct, 3 hours (lacunar infarcts 5 hours, non-lacunar infarcts 2 hours) and intracerebral hemorrhage, 2 hours. Patients with severe stroke arrive earlier at the hospital (p < 0.001). Neither sex, age, nor vascular risk factors influence the delay time. CONCLUSIONS: The arrival time varies with stroke subtype: patients with intracerebral hemorrhage or TIA arrive earlier than those with cerebral infarct, and non-lacunar infarcts earlier than lacunar ones. Furthermore, patients with severe stroke are admitted sooner at the hospital. PMID- 9951011 TI - [The risk of hemorrhage in long-term use of aspirin and triflusal]. AB - INTRODUCTION: Different studies have shown that aspirin (AAS), in low doses, may lead to a considerable frequency of hemorrhagic complications when used in the long term. OBJECTIVE: We compare the long-term occurrence of hemorrhagic complications with low doses of AAS and high doses of triflusal. PATIENTS AND METHODS: Our series included 106 patients who took 900 mg triflusal per day (300 mg 3 times per day) and 111 who took AAS (330 mg/day once daily). The former were followed up for an average period of 48.3 months (20-94) and the latter for 46.3 months (2-84). The average follow-up period for the study was 47.3 months. The presence of hemorrhagic complications was evaluated, as was their frequency and follow-up curve. RESULTS: Compared with AAS, triflusal led to a 76% reduction in risk of hemorrhagic complications (2.8% against 10.8%; OR 0.24; IC 0.06-0.94). There was a slightly increased incidence of hemorrhages in the women's group. There were more hemorrhages than gastrointestinal hemorrhages (4.5% against 0.9%) and intracranial hemorrhages (1.8%-0.9%). The follow-up curve showed significant differences in the form of an increased risk of hemorrhagic complications with AAS. CONCLUSIONS: The risk of hemorrhage with AAS depended on the period of follow-up, in a similar manner to with oral anticoagulant agents, in patients with prophylaxis of cerebral infarct. On the other hand, this did not occur with triflusal, with which the risk was homogeneous and lower in the long term. PMID- 9951012 TI - [Electrophysiological characteristics of asymptomatic relatives of patients with type 2 spinocerebellar ataxia]. AB - INTRODUCTION: Electrophysiological studies have been shown to be useful in hereditary ataxia, but only a small number of patients have been studied, and the duration of the illness, serial studies and molecular definition have not been taken into account. OBJECTIVE: We proposed, by means of electrophysiological techniques, to characterize the functional evolutionary state of the afferent and efferent systems in asymptomatic relations of patients with type 2 spinocerebellar ataxia (SCA2). Patients and methods. A 10 year longitudinal, prospective study was made of 59 children of patients with SCA2. The sequence included four studies: 1986, 1991, 1994 and 1996, all with informed consent for the investigation. The control group consisted of 108 volunteers. The electrophysiological studies recorded were: conduction studies in peripheral nerves and multimodal evoked potentials. For statistical analysis multivariate methods were used with a confidence interval of 95% (alpha = 0.05). RESULTS: Electrophysiological alterations were observed even in the absence of clinical signs, such as reduced amplitude of sensory potentials, morphological changes and prolonged latency of the central components of somatosensory evoked potentials, and of brain stem auditory evoked potentials, whilst the visual evoked potentials remained normal. Of 79 relations studied during the 10 year investigation, 17 had clinical signs and were considered to be patients with SCA2. CONCLUSIONS: Four stages of the illness were defined: 'healthy', presymptomatic, and patients with and without nerve conduction block. These characterized the degenerative mechanisms of the afferent and efferent systems of the relations of patients with SCA2 who became ill themselves. PMID- 9951013 TI - [Section of the median nerve at the wrist]. AB - INTRODUCTION: The usefulness of neurophysiological studies of peripheral nerves depends basically on an understanding of the physiopathology, especially of the evolutionary aspects of the phenomena of reinnervation. CLINICAL CASE: We present the case of a girl with complete section and immediate anastomosis of the two cut ends of the median nerve, at the wrist. Sixty two days later she had unmistakable signs of reinnervation (response in the thenar eminence to an electrical stimulus of 300 uV in amplitude and 42 ms in latency, with denervation and reinnervation on the EMG of the abductor pollicis brevis muscle). DISCUSSION: The findings in our patient show a rather faster rate of nerve regeneration than is usually accepted in the literature. This may have been due to suitable selection of some of the parameters of the neurophysiological study, such as time of analysis and sensitivity, which when not satisfactory may lead to an impression of failure or delay in reinnervation. PMID- 9951014 TI - [Pseudotumor forms of demyelinating diseases. Report of three cases and review of the literature]. AB - INTRODUCTION AND CLINICAL CASES: We present three patients with unusual clinical findings studied in our hospital, after a period of follow-up of at least two years from the time of diagnosis of their demyelinating condition. We discuss the clinical onset, CT and magnetic resonance findings, neuropathological studies and posterior clinical course. Anatomopathological studies were done in two of the cases, since the diagnoses were not clear and the other paraclinical investigations did not clarify things. DISCUSSION: The presence of large space occupying lesions or ring-like outlines in myelinating disorders may make it difficult to make a differential diagnosis from other conditions such as neoplasias and abscesses. This may lead to an erroneous initial diagnosis and even to the use of unsuitable, aggressive treatments. CONCLUSIONS: In young patients in whom radiological imaging suggests space-occupying lesions (single or multiple) one should consider the possibility of a primary demyelinating disease of the central nervous system with the appearance of a pseudo-tumour. In certain cases, stereotaxic biopsy should be considered if the diagnosis remains in doubt, rather than begin unsuitable treatment. The fundamental reason for the presentation of our cases is to emphasize that these pseudo-tumoral forms of demyelinating diseases should be considered in diagnosis. PMID- 9951015 TI - [Neurosyphilis and the prozone effect]. AB - INTRODUCTION: Neurosyphilis (NS) is an entity which still frequently presents to our Neurology Department. The prozone phenomenon occurs in approximately 2% of all cases of late primary syphilis or secondary syphilis; we have found no cases described of prozone and neurosyphilis occurring together. CLINICAL CASE: We present the unusual case of a 44 year old patient with NS and dementia PGP (progressive general paralysis). Initially serum VDRL was negative, but in CSF reacted at dilutions of 1:32. When serum VDRL was repeated using dilutions, it was reactive 1:128 and serum FTA was also reactive. The patient was treated with i.v. crystalline penicillin, after which his condition improved. CONCLUSIONS: We wish to draw attention to the possibility that patients with a dementia syndrome and negative serum VDRL may have the prozone phenomenon, and the laboratory should therefore be asked to do serial dilutions. PMID- 9951016 TI - [Neuro-radiological findings in probable moyamoya disease]. AB - INTRODUCTION: Unilateral moyamoya disease presents as unilateral stenosis or obstruction of the supraclinoid internal carotid artery, which causes cerebral hypoperfusion resulting in seizures or transitorial ischemic accidents (TIA). CLINICAL CASE: Atypical moyamoya disease was diagnosed as the cause of intraventricular hemorrhage in a 41 year-old-woman. The cerebral angiography, CT, MR and brain SPECT are reported. CONCLUSION: We discuss the clinic course and diagnostic techniques in this unilateral, atypical moyamoya disease and which steps are necessary toward an acceptable method for diagnosis and pursuit. PMID- 9951017 TI - [Moebius syndrome. Three different forms of presentation]. AB - INTRODUCTION: Moebius's syndrome is an entity present at birth, characterized by oculofacial paralysis and external ophthalmoplegia. Other cranial nerves can also be affected and associated to skeletal abnormalities and neurologic symptoms. It appears sporadically, sometimes of familiar nature, presenting special facies with total absence of facial expression and severe strabismus. The pathogenesis of the syndrome still remains unknown, being the transitory situation of fetal hypoxia/ischemic the most accepted theory. In some cases chromosomal abnormalities have been detected. CLINICAL CASE: We reported three children with different symptoms, two of them are siblings whose father is affected, but he was not diagnosed until adult age. CONCLUSIONS: We conclude pointing out the different presentation of the disease, the appearance in several members of a family and its chronically evolution. PMID- 9951018 TI - [Giant fusiform aneurysm of the middle cerebral artery. Surgical treatment with multiple clipping: a case report]. AB - INTRODUCTION: Giant cerebral aneurysms (GCA) are defined by sizes above 2.5 cm. GCA clinically appear by the mass effect exerted on adjacent structures, and in other cases, by embolismal action of the mural thrombo or as a post rupture subarachnoid hemorrhage. THERAPEUTICAL OPTIONS INCLUDE: inducting mural thrombosis, inserting an intraneurysmatic balloon, setting a bypass and surgical clipping. The major characteristics of giant fusiform aneurysm (GFA), the lack of neck and the inclusion of main vessels, give surgical treatment a great complexity. CLINICAL CASE: 25 year old woman diagnosed of GFA of the middle cerebral artery, treated with direct surgical access with clipping and reconstruction of the vascular wall with fenestrated clips arranged in tandem. CONCLUSIONS: The lack of an accessible neck for clipping and exclusion of giant and fusiform intracranial aneurysms, forced practising bypass as a compulsory surgical alternative. Multiple clipping was a viable choice because of its simplicity and less surgical risk. This technique is not applicable to giant serpentine aneurysms as it is only feasible in cases of fusiform aneurysms with no intraluminal thrombosis. A satisfactory evolution of this case, keeping asintomatic after 18 months of the intervention guarantees its application in young patients with giant thrombosed aneurysms of low clinical repercussion. PMID- 9951019 TI - [Subarachnoid hemorrhage as a form of onset of systemic lupus erythematosus]. AB - INTRODUCTION: The most frequent cause of spontaneous subarachnoid hemorrhage (SAH) is rupture of intracranial arterial aneurysms (> 70%). The remainder are due to many different aetiologies. Although SAH is a relatively common neuropathological finding in systemic lupus erythematosus (SLE), it is normally due to the extent of the intercerebral hemorrhage and not to its isolated presentation. CLINICAL CASE: We report the case of a 34 year old woman who presented with non-traumatic SAH at the onset of her lupus disorder. The patient was attended for SAH and at the same time a multisystemic disorder and severe thrombocytopenia were found, leading to a diagnosis of SLE. The neuroimaging techniques, selective cerebral arteriography, cerebral and spinal magnetic resonance, and magnetic resonance angiography did not show any vascular malformations. The patient was treated with immunosuppressive therapy, nimodipine, and following angiographic tests, with antiaggregants and anticoagulants. CONCLUSIONS: The greater frequency of SAH in patients with lupus, as compared to the general population, has been attributed to the presence of intracranial vasculitis. However, neuropathological studies have shown that true vasculitis is very infrequent in the central nervous system of SLE patients. In the case we describe, the first in which SAH appeared at the onset of the disease, we consider that the origin of the hemorrhage was her high arterial blood pressure and thrombopenia. PMID- 9951020 TI - [Meningitis due to Salmonella in the neonatal period]. AB - INTRODUCTION: Meningitis due to Salmonella is an unusual sign of salmonellosis. Usually Salmonella causes clinical disorders of the digestive tract, but on occasions, especially in babies, may cause focalized infections such as meningitis. Although meningitis due to Salmonella is unusual, it should be remembered because of its gravity, since it has a high morbimortality. It mainly affects neonatal babies and those under 4 months of age. It usually precedes or is accompanied by gastroenteritis and has a rapid clinical course. CLINICAL CASE: We present the case of a neonatal baby girl, 17 days old, who was very irritable, had liquid or semi-liquid faeces and high fever of unknown origin with poor response to antipyretic drugs. On lumbar puncture a cloudy liquid, compatible with bacterial meningitis was obtained. Treatment was therefore started immediately with intravenous ampicillin and cefotaxima. CSF culture grew Salmonella which was resistant to ampicillin but sensitive to cefotaxima. Antibiotic treatment was given for 21 days. There was excellent clinical recovery. After eight months of follow-up no sequelae have been seen and her development, both psychomotor, in height and in weight is normal for her age. CONCLUSION: Meningitis due to Salmonella is an unusual condition. Immediate, suitable treatment is essential to obtain satisfactory recovery. PMID- 9951021 TI - [Carpal tunnel syndrome in childhood. A case of early onset]. AB - INTRODUCTION: The carpal tunnel syndrome (CTS) is the commonest neuropathy due to compression to be seen in adults. There are very few cases in the literature referring to patients of paediatric age, particularly those under ten years old. Most of these young patients had a metabolic disorder (mucopolysaccharidosis (MPS) or mucolipidosis (ML). In fact, as many as 90% of the MPS had CTS, sometimes subclinically. This syndrome is caused by compression of the median nerve at the level of the carpal tunnel, to which multiple factors may contribute, both local and systemic, as reviewed in this paper. The clinical findings differ from those in adults, but the appearance of suggestive symptoms and signs should make one suspect the condition and request an electromyographic study (EMG) which would be diagnostic. CLINICAL CASE: We describe the case of a five year old girl, with a clinical history suggesting the presence of a carpal tunnel syndrome for 12 months and characterized by paraesthesia and limitation of flexon-extension movements of the fingers of the affected hand, with pain on movement. The symptoms appeared on waking in the morning, gradually improved as the day advanced and became bilateral over a period of six months. The diagnosis was confirmed by EMG and MR helped to clarify the aetiology. CONCLUSION: The interesting aspect of this article is the youth of the patient, the absence of known etiological factors and the presence of tenosynovitis detected on MR as has been described in some idiopathic/familial forms. PMID- 9951022 TI - [Response to chemotherapy in cerebral primary lymphoma]. AB - INTRODUCTION: Primary central nervous system lymphomas (PCNSL) are infrequent, rapidly growing and generally limited to the central nervous system (CNS). In recent years there has been a threefold increase in cases occurring in immunocompetent individuals. Conventional treatment with corticosteroids and radiotherapy is effective, but over 80% relapse in less than a year. Chemotherapy has significantly improved the results of treatment. CLINICAL CASE: We present a case of PCNSL in an immunocompetent patient which was resistant to radiotherapy (RT). There was progression of the lymphoma three months after irradiation, and later multicentric progression one month after radiosurgery. The patient had complete radiological remission after systemic chemotherapy. The clinical improvement was obvious, since before chemotherapy was started the patient was in coma and had episodes of apnea. The therapeutic response obtained was consolidated by intensive chemotherapy and hemopoietic support. The condition is still in remission three years after completion of this treatment. CONCLUSIONS: There are no publications about the results of combined radiotherapy and chemotherapy in series of patients with PCNSL, since there are relatively few patients and many methods of treatment are tried. PMID- 9951023 TI - [Sjogren syndrome and subacute demyelinating polyradiculopathy: an unusual association]. AB - INTRODUCTION: Sjogren's syndrome is a chronic inflammatory condition of unknown aetiology and autoimmune pathology. The defining feature is the dry syndrome, expressed as xerophthalmia and xerostomia. Extra-glandular involvement at many other levels may also occur. Neurological involvement is not unusual. The peripheral nervous system is most frequently involved, and a predominantly sensitive symmetrical distal polyneuropathy may be the first sign of the condition. Other patterns of peripheral involvement are also associated with the syndrome. We present a case of subacute demyelinating polyradiculopathy associated with primary Sjogren's syndrome. CLINICAL CASE: A 28 year old woman with dry syndrome presented with paraesthesia in her hands and feet, distal weakness, which had progressed proximally in the muscles of her arms and legs, and bilateral facial weakness. The condition progressed for eight weeks. When complementary tests were done, alterations typical of this condition (FR, ANA, anti-Ro and anti-La) were seen and also others typical of the dry syndrome (Schirmer's test). Therefore, in view of these findings and the clinical features, after other conditions had been ruled out, a diagnosis of primary Sjogren's syndrome was made. The type of neuropathy was determined by the clinical features, electromyography and CSF findings. Treatment with corticosteroids gave good results. CONCLUSIONS: Demyelinating polyradiculopathy is a form of peripheral nervous system involvement which is rarely seen in this disorder. In the differential diagnosis Sjogren's syndrome should be considered, an orientative history taken, autoantibodies determined and an ophthalmological examination made. PMID- 9951024 TI - [Spinal cord compression secondary to epidural extramedullary hematopoiesis in thalassemia: a clinical case and review of literature]. AB - INTRODUCTION: Extramedullary hematopoiesis generally occurs in a variety of hematological disorders where the normal functioning of the blood forming organs is disturbed. It is a common manifestation in thalassemia where it occurs as a compensatory phenomenon in order to combat long standing anemia. Spinal cord compression as a consequence of extramedullary hematopoiesis in the intraspinal epidural space is an extremely rare complication, though this complication has been reported more commonly in thalassemia. CLINICAL CASE: A case of spinal cord compression due to extramedullary hematopoiesis in a patient with thalassemia is reported. The patient was successfully treated with radiation therapy and blood transfusions and he made a complete clinical recovery. Development. The literature is reviewed and the efficacy of several treatments such as surgery, radiotherapy and blood transfusion therapy is discussed. Until recently surgical decompression followed by radiation therapy remained the recommended treatment. Hematopoietic tissue is particularly sensitive to the ionizing radiation and low dose radiotherapy is enough to relieve the spinal cord compression. Blood transfusion therapy may be diagnostically and therapeutically useful in the management of this entity. CONCLUSIONS: A prompt recognition of the syndrome and early treatment with radiotherapy and blood transfusion therapy is recommended to prevent irreversible damage to the spinal cord. Surgery may be only considered in the event of progressive neurological deficit despite of radiotherapy or blood transfusion therapy. PMID- 9951025 TI - [Acute presentation of leukodystrophy due to mitochondrial cytopathology and multiple deletions of mitochondrial DNA]. AB - INTRODUCTION: Deletions of mitochondrial DNA (mtDNA) are a known cause of various mitochondrial cytopathies, which are sporadic and usually not due to maternal transmission. The multiple deletions are usually transmitted on a Mendelian pattern, and are frequently of autosomal dominant character. Leukodystrophy may be part of the picture, or even the form of presentation, of some mitochondrial cytopathies. Thus, in a case of leukoencephaly of unknown origin, mitochondrial cytopathy should be considered in the differential diagnosis. CLINICAL CASE: We present the case of a boy with no previous clinical abnormalities who, at the age of 13, suddenly fell to the floor with an encephalopathy which required aggressive treatment, needing mechanical ventilation and prolonged sedation. Following partial recovery spastic-dystonic quadriplegia remained. Neuroimaging showed advanced leukodystrophy with small hemorrhages in the white matter, which later disappeared. After rejecting other aetiologies, mitochondrial cytopathies in muscle were studied. A partial defect of the I and IV complexes of the respiratory chain and two deletions of mtDNA were shown. CONCLUSIONS: This case is another example of the variable clinical presentation of mitochondrial cytopathies and yet another argument for their inclusion in the diagnosis of leukodystrophy of unknown origin. PMID- 9951026 TI - [Ganglion cell tumors]. AB - INTRODUCTION: Tumours of ganglion cells are very rare. They include: gangliocytoma, ganglioneuroma, Lhermitte-Duclos disease and dysembryoplastic neuroepithelial tumour. All require microscope identification of well differentiated neurons for diagnosis. Their pathogenesis is not fully understood. Some workers consider them to be dysplasias rather than true neoplasias; others refer to them as malformations. OBJECTIVE: We aim to analyze the most characteristic findings of these tumours with regard to the elements of which they are composed, their epidemiology, behavior on imaging investigations (CT and MR) and treatment. CLINICAL CASES: We present two cases: one patient with a gangliocytoma and one with a ganglioglioma. Both were treated surgically, confirmed on histological study and had good clinical results. PMID- 9951027 TI - [Intra-arterial fibrinolysis in acute thrombosis of the basilar artery]. AB - INTRODUCTION: Ischemia in the territory of the basilar artery presents with a variable clinical picture of hemiparesia-tetraplegia, progressive deterioration of level of consciousness, irregular respiration and apnea leading to irreversible coma and death in between 75% and 86% of cases. The usual treatment is supportive. CLINICAL CASE: We present the case of a 49 year old woman with acute thrombosis of the basilar artery and a progressive course leading to coma. No bulbar lesions were seen on the CT scan done in the Emergency Department. Thrombosis of the basilar artery and permeable bilateral carotid systems were shown on arteriography. There were no contra-indications to fibrinolysis. Following local fibrinolytic treatment with urokinase the patient had full recovery from her neurological disorder and no sequelae. The basilar artery remained permeable six months later. CONCLUSIONS: Emergency treatment with cerebral intra-arterial fibrinolysis within the first six hours, in a case of neurological deficit progressing in the basilar artery territory, with persistence of brain-stem functions and no signs of decerebration (provided there are no contra-indications to fibrinolysis and the initial cerebral CT scan shows no bulbar lesions) may save the patient's life, with total or partial recovery of brain-stem function. PMID- 9951028 TI - [Non-hereditary +hyperekplexia. Study of a patient with unusual ictal EEG features and review of the literature]. AB - INTRODUCTION AND CLINICAL CASE: We present a male patient which presented distal muscular stiffness, from the first hours of the life. At this time, he also presented episodes of generalized muscular hypertonia with cyanosis and apnoea, started by somato-sensorial stimuli. Those episodes were terminated by passive flexion of the extremities and the head. Later, dream myoclonic jolts appeared. EEG tracings during hypertonic episodes showed an initial artefact potential followed by bursts of rhythmic and repetitive acute potentials in the bilateral fronto-central regions, at a 20-22 Hz frequency, similar to an epileptiform spike wave burst. The EMG showed a continuous muscular activity, suppressed by rest and the administration of diazepam. Treatment with oral diazepam has been very effective. Now, the patient is four years old, is asymptomatic and continues treatment with oral diazepam. If the dose is decreased, the child starts unstable march, startle response on somatosensory stimuli with falls, and above all nocturnal myoclonia. The patient does not have familiar antecedents of hyperekplexia, even in its minor form. CONCLUSION: Clinical picture suggests us a not familiar form of hyperekplexia. PMID- 9951029 TI - [Holmes-Adie syndrome. Clinical case]. AB - INTRODUCTION: The Adie tonic pupil is an intrinsic, isolated and benign ophthalmoplegia producing defective accommodation and anisocoria. The affectation is unilateral in the 90% of cases and can appear at any age. If associated to patellar tendinous reflexes abolition, constitutes Holmes-Adie syndrome. CLINICAL CASE: We present a 6 years old girl. She suffered a right temporal trauma with cephalea and vomiting for a few hours. After two months, she presented right mydriasis. There were no familiar antecedents. After a year evolution, she has not presented clinical changes. CONCLUSION: We comment the process's physiopathology. PMID- 9951030 TI - [Riluzole as a treatment for amyotrophic lateral sclerosis]. AB - INTRODUCTION: The Amyotrophic Lateral Sclerosis (ALS) is a disease characterized by the selective degeneracy of the superior motoneurons of the cortex motor and of the inferior motoneurons at level of the encephalic trunk and spinal marrow. Exist sporadic and familiar forms, being estimated an incidence of 1-2 cases by 100,000 inhabitants. The cause of the neuronal degeneracy is yet unknown, being implied, between other mechanisms, the glutamic exotoxicity is the responsible for the death neuronal. The riluzol is a benzothiazole derivative whose neuroprotector mechanism still it has not been totally clarified, though seems that reduces the neuroexcitatory action of the glutamic acid blocking his transmission. DEVELOPMENT: Two clinical trials have been accomplished with similar characteristics: multicentre, randomized, double blind, and placebo controlled. Between both studies have been included more than 1,100 patient, obtained significant statistic results in the prolongation of the survival time, however this effect was not going accompanied of an improvement in the muscular force neither of the pulmonary capacity, what is translated in which the riluzol does not modify the quality of life of the patient. The drug presents good tolerance and mild adverse effects and as consequence of this in 1996, the FDA approved his marketing and utilization in the treatment of the ALS. The approval of the riluzol as first agent for the treatment of the ALS has raised an important number of problems about the efficiency and cost of the treatment. CONCLUSION: Though its benefits are modest, it is considered a starting point in the pharmacotherapy of the ALS. PMID- 9951031 TI - [Prevention and treatment of headache due to intracranial hypotension]. AB - INTRODUCTION: In spite of the large number of authors who have studied headache following lumbar puncture and spontaneous intra-cranial hypotension, many aspects remain little known, and there is still no completely satisfactory non-invasive treatment. DEVELOPMENT: In one group of patients there is an increased risk of post lumbar-puncture headache: adults between 20 and 50 years old, of low body weight and a previous history of chronic bilateral headache. In these patients all possible prophylactic measures should be taken whilst the lumbar puncture is being performed, so as to avoid the onset of headache. Use of modern atraumatic needles of small diameter and with a lateral opening have been shown by many studies to be satisfactory. There are also other manoevres which help to reduce the frequency of post lumbar-puncture headache, such as the insertion and withdrawal of the needle with the bevel parallel to the fibres of the dura mater and reinsertion of the stylet before withdrawing the needle. Once the patient has developed post lumbar-puncture headache, or spontaneous intracranial hypotension, initially treatment with cerebral vasoconstrictors such as oral caffeine may be used. After a period of time (2-4 weeks) which makes spontaneous regression of the headache unlikely, the treatment of choice involves epidural patches. CONCLUSION: Well-designed studies are necessary to demonstrate the efficacy of oral caffeine (and other drugs) in post lumbar-puncture headache. PMID- 9951032 TI - [Memory in multiple sclerosis: review of performance and relationship with clinical variables and neuroimaging]. AB - INTRODUCTION: Neuropsychological studies in multiple sclerosis (MS) mainly have centred on the study of memory disorder. DEVELOPMENT: The prevalence of memory deficits in MS population is around 40-60%. These deficits could be sum up in an impaired immediate memory, a learning capacity lower than normal controls subjects and a worse long term memory. The results of the reviewed studies about the relationship between performance in memory tasks and clinical variables, show that physical disability and depressive symptoms do not influence this performance. Whilst, years of evolution and, mainly, disease course are related to a worse performance in memory tasks. In structural neuroimaging studies (CT and MRI) it is considered that ventricular dilatation and the total lesion load are predictor variables of MS patients performance in different memory tasks. CONCLUSION: This paper reviews several studies relative to amnesic function in subjects suffering from MS, emphasizing the most relevant contributions of the present neuropsychological literature. PMID- 9951033 TI - [Fetal nerve tissue, ethics and transplants]. AB - INTRODUCTION: The moral-ethical problem of the use of human embryos as a source of cells for neurotransplants involves serious conflicts as to which tissues to use, from which source, what method should be used to obtain them and also the search for alternative sources of tissues. DEVELOPMENT: In this paper we present a brief summary of ethical and medical points involved in the obtention, protection of the donor, preparation, safety and efficacy of human foetal nervous tissue in the context of neural transplants. The ethics of human foetal nervous tissue are very complex in that they represent a dilemma involving several points of medical ethics, which are themselves very controversial, including abortion, transplants and incorporation in the cerebral function of an individual. From a bioethical point of view, we consider aspects such as the establishment of an optimal source for obtention of nervous tissue for transplants, the safety and efficacy of this, informed consent for donation of tissue, availability and storage among other aspects. CONCLUSIONS: All programmes that envisage the use of foetal tissue for the purpose of transplants should strictly and truly conform to local and national ethical regulations before starting clinical trials. PMID- 9951034 TI - [Physiopathology of neurological signs of hypoxanthine-guanine phosphoribosyltransferase deficiency]. AB - OBJECTIVE: Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency is characterized by an increase in renal uric acid excretion, usually with hyperuricemia and may be associated with more or less important neurological symptoms. Based on a series of 20 patients from 16 Spanish families we propose that HPRT deficiency could be clinically classified in four different groups. In the more severe form (classic Lesch-Nyhan syndrome) HPRT deficiency is characterized by choreoathetosis, spasticity, mental retardation and compulsive self-mutilation behavior. The pathophysiology of the neurological symptoms remains unclear and there is no effective therapy. This review is intended to provide a research strategy for a better knowledge of the neurological pathophysiology of HPRT deficiency. DEVELOPMENT: We have analyzed the knowledge on the neurological symptoms of HPRT deficiency. This knowledge comes from histopathological studies of the brains from Lesch-Nyhan patients, chemical studies of the cerebrospinal fluid, experimental animal models (pharmacologic and lesioning and genetic approaches), and human in vivo studies with positron emission tomography. CONCLUSIONS: The observed findings suggest that the neurological symptoms of Lesch-Nyhan syndrome could be related with the neonatal neuronal and/or dopaminergic terminations damage. This damage could be due to lost or reorganization of dopaminergic system, and is associated with a reduced dopamine levels and with hypersensitivity of the D1 subclass dopamine receptors. PMID- 9951035 TI - [Register Alacant: register of the treatment of supra-aortic trunk stenosis with angioplasty and stent placement. Study group of Register Alacant]. AB - INTRODUCTION: The Register Alacant is a clinico-radiological register of patients in Alicante province with symptomatic carotid or vertebral artery stenosis, treated by means of percutaneous transluminal angioplasty and subsequent placement of a Stent-type endovascular prosthesis. DEVELOPMENT: The aims of the register are as follows: 1. To evaluate the safety of this type of treatment. 2. To measure the clinical ultrasonographic and radiological efficacy of the technique in the short, intermediate and long term. In this article we consider the rational basis which led to its introduction and present the design of this register and aspects of organization which make it work in practice. There is only one centre (HG SVS Alicante) where this technique is used for treatment and another seven centres from which patients are 'recruited' and sent for angioplasty. Whilst the procedure is being carried out, the patient is monitored by transcranial Doppler using both medial cerebral arteries. On completion of the angioplasty the patients is immediately assessed clinically and subsequently daily for the first two post-operative days. Further follow-up is done in the centre which initially corresponded to each patient. Carotid eco-Doppler is done weekly as follow-up. Digital angiography is done one year later. All patients are followed-up indefinitely. The minimum follow-up period is one year, although three years or more are recommended. CONCLUSION: The register was started in April 1998 and monthly meetings are held to discuss and programme each case, and all the investigators participate in this. PMID- 9951036 TI - [Essential tremor: a review of pathogenic mechanisms]. AB - INTRODUCTION: Essential tremor (ET) is the commonest involuntary movement observed and is seen when a given posture is maintained. Although it does not affect life expectancy, it may cause considerable functional disability and serious psychological effects in the affected person. DEVELOPMENT: ET is a heterogeneous clinical condition. Its physiopathology is still not known, is very complex and involves many mechanisms, both structural and biochemical, although as yet there is no theory to include them all. In view of what is known at present, it may be accepted that there is a central oscillator at olive cerebellar-thalamic-cortical-spinal level, which is the primary generator of ET, modulated by a peripheral component. The tremor results from interaction between increased central excitability and peripheral regulation, which in turn reinforces the central overactivity. It may also be that the monoaminergic system (catecholaminergic and serotoninergic), adrenoreceptors (especially the B2 muscular adreno-receptors) and the bodily structure itself, amongst other factors, may influence the pathogenic mechanism of ET. It is likely that there is a multifactorial genetic disorder which predetermines this physiopathogenic process, although this has not yet been determined. CONCLUSIONS: In this paper we review the various hypotheses and existing knowledge related to the aetiopathogenesis of TE. PMID- 9951037 TI - [Progressive hemiplegia and complete paralysis of the third cranial nerve as a clinical sign of a hemi-lateral mesencephalic-pontine bulbar infarct]. PMID- 9951038 TI - [Acute phenytoin poisoning due to its interaction with fluoropyramidine]. PMID- 9951039 TI - [Multiple nodular heterotopias and Kallman's syndrome]. PMID- 9951040 TI - [Fatigue and multiple sclerosis: a study in a health district in the province of Zaragoza]. PMID- 9951041 TI - [Ear lobe sulcus and ischemic cerebrovascular disease]. PMID- 9951043 TI - [Neurosciences: an example of an interdisciplinary approach as an efficient strategy in the scientific investigation]. PMID- 9951042 TI - [Pontine hematoma secondary to aneurysm of the PICA]. PMID- 9951044 TI - [ELectro-trauma by lightning through the telephone]. PMID- 9951045 TI - Huperzine A--an interesting anticholinesterase compound from the Chinese herbal medicine. AB - Huperzine A, alkaloid from the Chinese herbal medicine Qian Ceng Ta, which is prepared from the moss Huperzia serrata, has been used in China for centuries to treat fever and inflammation. Huperzine A is a strong inhibitor of cholinesterases with high selectivity to acetylcholinesterase and in China is developed as therapeutic against Alzheimer's disease. May be that huperzine A will be better than other centrally active anticholinesterases in treating this neurodegenerative disorder. Huperzine A appears to have additional pharmacological properties that make it an attractive candidate therapy for clinical trials. PMID- 9951046 TI - Hyperprolactinemia in obese as well as in lean females of Koletsky rats: effect of long lasting terguride treatment. AB - Plasma prolactin was measured in genetically hypertensive obese Koletsky rats, in their lean siblings and in normotensive rats of Wistar strain. Lean as well as obese females show hyperprolactinemia. The males of Wistar strain as well as obese rats and their siblings show comparable prolactinemia except lean males which show higher level than Wistar males. Sex dependence of prolactinemia is missing in the rats of Wistar strain. Long lasting terguride treatment decreases prolactinemia in obese as well as lean rats of both sexes. The drug showed decreased prolactinemia in the males of Wistar strain. When the group of rats are considered in correlation computation positive correlation can be documented between total plasma cholesterol and plasma prolactin. In obese females positive correlation was found between plasma insulin and plasma prolactin. PMID- 9951047 TI - Development of lipid and glycide abnormalities in genetically hypertensive obese Koletsky rats and in their lean siblings. AB - Experiments were performed in the genetically hypertensive Koletsky rats and in their lean siblings at the age of two and three months. In the study of development of glycide and lipid abnormalities animal represents control for itself. At the age of two months Koletsky obese rats show relative to their lean controls elevation of plasma triglycerides (males +184%, female +152%) and insulin (males +169%, females +201%). During one month plasma triglycerides elevated in lean males +9%, in lean females 0%, but in obese males +21%, in obese females +139%. Considering insulinemia similar results were obtained. Thus during one month insulin elevates in lean males +19%, in lean females +23%, but in obese males +80%, in obese females +144%. During one month glucose intolerance is elevated as well only in obese rats. Total plasma cholesterol during period of one month shows no changes in both substrains of rats. Similar picture can be found in basal glycemia. In all groups of rats no changes were registered except one, i.e., obese females show decrease. Considering the substrain differences in basal glycemia then at age of one as well as two months obese of both sexes show elevation. As to the body weight at the age of two as well as three months there is increase in obese rats. The changes of body weight during one month are expressively higher in obese rats. PMID- 9951048 TI - Systemic nicotine administration suppresses food intake via reduced meal sizes in both male and female rats. AB - The appetite suppressing effect of tobacco products, via the main pharmacological agent nicotine, is a major reason for its usage both by woman and man. Food intake (FI) could be changed by altering either meal size (MZ) or meal number (MN), which are regulated dependently in a reciprocal manner. The present study investigated the effect of systemic nicotine administration on the rat feeding pattern. Because of gender differences in the effects of nicotine, both male and female rats were studied. Alzet mini-osmotic pumps (Model 2001) and the automated rat eatometer were used to evaluate the feeding pattern of male and female Fischer 344 rats during seven days of systemic nicotine infusion (6 mg/kg b.w. s.c.). The main findings are: 1) systemic nicotine infusion decreased food intake in both sexes; 2) the decreased food intake was due to significantly reduced meal sizes while meal numbers were not altered significantly in either males or females; 3) the cyclical pattern of vaginal smears, food intake, meal number and meal size of female rats was not affected by nicotine administration. We conclude that the feeding suppressive effect of nicotine, which is due to reduced meal sizes and thus satiation, is not sex-hormones related. PMID- 9951049 TI - Medium-term results of coronary artery bypass surgery in patients with severe left ventricular dysfunction and preoperatively documented hibernating myocardium. AB - In patients with multivessel coronary artery disease (CAD), severe left ventricular dysfunction (LVD) and hibernating myocardium (HM) demonstrated on preoperative assessment, coronary artery bypass grafting (CABG) surgery can be performed safely with low operative morbidity and mortality rates. Surgical revascularization of reversibly dysfunctional myocardium improves significantly both patient's clinical status and left ventricular ejection fraction (LVEF). Diagnosis of HM prior to CABG surgery seems to be crucial because it does not leave the patient with multivessel CAD and LVD a candidate only for heart transplantation (HTX). In the presence of HM, more aggressive surgical approach could be recommended to salvage chronically jeopardized but viable myocardium using not only routine CABG procedures in extracorporeal circulation (ECC) but also alternative approach of coronary endarterectomy (EAE) or minimally invasive direct coronary artery bypass grafting (MIDCAB) procedures on beating heart, without any adverse impact on operative mortality. PMID- 9951050 TI - [Acute myocardial infarct]. PMID- 9951051 TI - [Thrombolytic treatment of acute myocardial infarct. 1]. AB - I-Rationale of thrombolytic therapy in acute myocardial infarction (AMI). II Thrombolytic drugs. III-Effects of thrombolytic therapy on mortality. IV-Studies comparing the effects of various thrombolytic agents on mortality. PMID- 9951052 TI - [Thrombolytic treatment of acute myocardial infarct. 2]. AB - V-Effects of thrombolytic therapy on coronary reperfusion and left ventricular function VI-Noninvasive markers of reperfusion. VII-Timing of thrombolysis. VIII Side effects and adverse outcomes. PMID- 9951053 TI - [Thrombolytic treatment of acute myocardial infarct. 3]. PMID- 9951054 TI - [Coronary angioplasty in the acute phase of myocardial infarct]. AB - Primary coronary angioplasty is a reperfusion method increasingly used for the treatment of acute myocardial infarction. Several studies are reviewed, demonstrating a reduction in mortality and morbidity, namely due to recurrent ischaemia and haemorrhagic stroke, in comparison to thrombolysis. This benefit seems larger in high risk patients, such as those with cardiogenic shock, anterior wall infarction, elderly patients and those with contraindications thrombolysis or with a non diagnostic electrocardiogram. PMID- 9951055 TI - [Post-myocardial infarct risk stratification]. AB - The aim of performing diagnostic tests in patients with myocardial infarction before hospital discharge is to identify those with a high risk of recurrence or sudden death. It is convenient to perform these tests before discharge because the risk is higher in the next two months. The assessment of ventricular function is fundamental since it is the best predictor of post-infarction survival. There are many patients in which the combination of clinical, electrocardiographic and enzymatic data present a strong argument to assume that the loss of contractile myocardium was relatively small. In the remaining patients, the use of non invasive techniques, or even contrast ventriculography, is indispensable. The choice of method, be it exercise electrocardiography, stress echocardiography, rest or stress scintigraphy and coronary ventriculography, depends greatly on the resources available and the degree of reliability offered by the team performing the method. The sub-maximal exercise test performed before hospital discharge in patients with an uncomplicated infarction has already an undisputed role in determining prognosis. Stress echocardiography and stress or exercise thallium scintigraphy have a greater predictive value than the sub-maximum stress test. Their greatest advantage probably lies in the possibility of identifying the patients with a low risk of future cardiac events. In many centers, coronary angiography and ventriculography are preferred with out "wasting" time with non invasive methods, which, although more economical, give only indirect information. The existence of complex ventricular arrhythmias is an independent prognostic factor concerning mortality. Ambulatory electrocardiography and electrophysiological studies are the methods of choice for their detection, the latter having become routine as their value has increased due to the availability of implantable automatic defibrillators. PMID- 9951056 TI - [Stress echocardiography in myocardial infarct]. AB - For patients with recent myocardial infarction, the main determinants of prognosis are: extent of transmural necrosis, state of the infarct-related artery and the presence and extent of myocardium at risk. The basic principle underlying the use of stress echocardiography states that myocardial ischaemia produces abnormalities of regional wall motion which are by themselves early, sensitive and specific markers of decreased perfusion. Dobutamine infusion allows for evaluation of myocardial contractile reserve by increasing inotropism. In low doses it gives us information on regional viability. In high doses, wall motion under increased oxygen demand, it becomes dependent on the ability of the coronary arteries to increase blood flow. Dipyridamole induces coronary vasodilation. In low doses it produces an increase in the blood flow. In high doses the steal effect deviates blood from the regions dependent on stenosed arteries. Ischaemia and regional wall motion abnormalities ensue. A negative stress echocardiogram, either under dobutamine or dipyridamole, has an excellent negative predictive value while a positive stress echocardiogram is predictive of an increased rate of events in the follow-up. PMID- 9951057 TI - [Myocardial viability. Concept, physiopathology. Methods and diagnostic value]. AB - The purpose of this study is to describe the concept and physiopathology of myocardial viability to provide rational use of diagnostic methodologies and their value. Great relevance has been given to the diagnosis of myocardial viability since it was published in 1982, because of the consequences of therapeutic decisions and prognostic evaluation on the patient's quality of life. The cost/benefit values of these methodologies must be adequate in clinical terms and carefully assessed. PMID- 9951058 TI - [High-resolution electrocardiography in acute myocardial infarct]. AB - The author starts by highlighting the importance of risk stratification in patients who have survived a myocardial infarction. High resolution electrocardiography, also called signal-averaged electrocardiography (SAECG), appears in this setting as a diagnostic tool that, by providing important information about the way the intraventricular conduction of the electrical impulse is made, contributes to the characterization of the arrhythmogenic substrate, which is the basis of ventricular tachycardia and fibrillation. By resorting to the averaging of the electrocardiographic signal, SAECG enables us to detect ventricular late potentials whenever the analysis of that signal is made in time-domain. Further details, which will enrich the information on ventricular activation, can be obtained if the analysis is made in the frequency domain (spectral analysis). The importance of detecting abnormalities in the SAECG recordings lies in the fact that those abnormalities are related to the occurrence of ventricular tachycardia and fibrillation, which are responsible for arrhythmic death. After referring to the criteria of positivity of SAECG and its reproducibility, the author approaches the most important part of the paper: the clinical applications of SAECG. After focusing on the interest of the method in noncoronary conditions, its usefulness in patients with acute myocardial infarction is pointed out. The author then mentions the prevalence of abnormalities in SAECG in patients with acute myocardial infarction and emphasizes the interest of the method in risk stratification. The author then presents the results of his Group in what concerns prevalence and prognosis. Finally, the author refers to the application of SAECG in other forms of coronary artery disease besides myocardial infarction. PMID- 9951059 TI - [Secondary prevention of myocardial infarct]. AB - Preventive measures are the most powerful measures to treat manifestations of ischemic cardiopathy. Secondary prevention of myocardial infarction involves the following intervention areas: a) Limitation of adverse physiological and emotional consequences of the acute illness; b) Identification of the patients particularly exposed to the risk of new episodes of ischemic cardiopathy or to their consequences, namely reinfarction and sudden death; c) Institution of therapeutic attitudes, surgical or medical, that can prolong life and can oppose functional deterioration and prevent symptoms; d) Institution of measures that can oppose the progression of the initial disease that is, in almost all cases, atherosclerosis. Measures that can oppose the progression of cardiac disease and its consequences after an episode of myocardial infarction, and measures that can oppose the evolution of atherosclerosis are described in this article. The measures that can influence the risk factors after an episode of myocardial infarction are briefly commented: characteristics related to life style and physical exercise; smoking habits; plasmatic lipid levels; high blood pressure; and therapeutic substitution with estrogens after menopause. Pharmacological interventions in secondary prevention of myocardial infarction are described, namely with the following groups of substances: beta-adrenergic blocking agents; platelet active agents; anticoagulants; and angiotensin-converting enzyme inhibitors. PMID- 9951060 TI - [Treatment acute myocardial infarct in the pre-hospital phase]. AB - The authors review and discuss the medical treatment in the prehospital phase of acute myocardial infarction while working at the Referral Centre for Emergency Patients of the National Institute for Medical Emergencies (CODU-INEM). The diagnosis of myocardial infarction should be suspected immediately by the doctor on duty at CODU-INEM in all patients with acute thoracic pain. Then it is essential to send a medical team to the scene as soon as possible after the onset of symptoms in order to treat and to prevent acute fatal complications. PMID- 9951061 TI - [Aortic peri-valvular abscess, mycotic aneurysm of Valsalva sinus, and fistula to the right ventricle in a context of acute infectious endocarditis]. AB - Infective endocarditis continues to attract the attention of many physicians. The authors present a case report of a 64 year old man with a history of infective endocarditis of a native aortic valve complicated by a perivalvular abscess, mycotic aneurysm of a sinus of valsalva and acquired aorta-right ventricular shunt. PMID- 9951062 TI - [Increase of creatine kinase mb isoenzyme out of a context of acute myocardial infarct]. AB - The increased serum level of the MB isoenzyme of creatine kinase is a very useful test for the diagnosis of acute myocardial infarction. However, there are several situations of false positives for this test that are scarcely mentioned in the standard medical references. We report a case of prostate carcinoma with a high serum creatine kinase BB fraction. The immunoinhibition method may cause a false increase in creatine kinase MB in this situation, which in the case presented suggested the diagnosis of myocardial infarction. We discuss patient diagnosis, laboratory methods for the determination of creatine kinase and the technical reasons for the false positives. PMID- 9951064 TI - [Evidence based medicine. A new paradigm for medical practice]. AB - Modern medical practice is an ever-changing process, and the doctor's need for information has been partially met by continuous medical education (CME) activities. It has been shown that CME activities have not prevented clinical knowledge, as well as medical practice, from deteriorating with time. When faced with the need to get the most recent and relevant information possible, the busy clinician has two major problems: most of the published medical literature is either irrelevant or not useful; and there is little time to read it. Evidence based medicine constitutes a new paradigm for medical practice in the sense that it tries to transform clinical problems into well formulated clinical questions, selecting and critically appraising scientific evidence with predefined and rigorous rules. It combines the expertise of the individual clinician with the best external evidence from clinical research for rational, ethical and efficacious practice. Evidence-based medicine can be taught and practiced by physicians with different degrees of autonomy, with several subspecialties, working in the hospital or in outpatient clinics, alone or in groups. PMID- 9951065 TI - [Cochrane collaboration. What is it? What is it for? How does it contribute to the practice of evidence based medicine?]. AB - This paper reviews Cochrane Collaboration and its structure. The authors explain the concepts of systematic review and meta-analysis. Some insights are provided on how products of the Cochrane Collaboration, namely the Cochrane Library, can contribute to the practice of Evidence-Based Medicine. PMID- 9951066 TI - [The correct formulation of clinical questions for the practice of evidence based medicine]. AB - Evidence-based medicine is the conscientious, explicit, and judicious use of the best evidence available to make decisions about the care of individual patients. The practice of EBM means integrating individual clinical expertise with the best available external clinical evidence from systematic research. The good practice of EBM begins with a well formulated clinical question, meaning that it should be clear, directly relevant to the problem at hand and answerable by searching in medical literature. This paper begins by presenting the central tasks of clinical work from which clinical questions arise. The components of well formulated clinical questions are then presented. Finally, some of the steps for the correct formulation of questions are discussed. PMID- 9951067 TI - [Critical assessment of articles on controlled clinical trials. I. Planning]. AB - This is the first of two articles concerning the techniques of critical appraisal of controlled clinical trials. It presents an overview of the delicate points of the following issues: operational questions; definition of primary and secondary variables, classification of the trial as pragmatic or explanatory, selection of the population sample, study design and its appropriateness to the goals, sample size and overall statistical analysis. Particular attention is given to the value of randomisation and blinding for the prevention of bias. PMID- 9951068 TI - [Critical assessment of articles on controlled clinical trials II. Results]. AB - The way trial results are reported affects the physician's decisions. We describe some methods for the critical appraisal of clinical trial results (relative risk, absolute risk reduction, number needed to treat, confidence intervals, etc.). PMID- 9951069 TI - [Guidelines and practice of evidence based medicine]. AB - This is a review paper with pedagogic goals in essence. The concept of guidelines is defined and the function and types of guidelines described. Different types of guidelines, such as normative, methodological and practice-motivated, are considered. The most common methods for the drafting of guidelines are presented. The difference between evidence-based guidelines and consensus-based guidelines is established and the importance of grading the strength of recommendations in guidelines, on basis of the validity of the evidence, is stressed. Finally, an update of the role of guidelines in the practice of EBM is put forward. PMID- 9951070 TI - [Assessment of glomerular filtration rate in a hospital population. Comparison of two methods]. AB - OBJECTIVES: This study was undertaken to assess the value of Cockroft-Gault Formula (FCG) in the patients of an Internal Medicine ward. METHODS: FCG was compared with creatinine clearance (DC) adjusted for corporal area. Serum creatinine was measured after 24 h urine collection and 8 h fast. By the subtraction of FCG from DC, the variable difference (DIF) was calculated. FCG was calculated using total body weight (PT) and lean body weight (PS). All patients were included unless they had renal failure. RESULTS: Renal function was calculated in 92 patients, 33 women and 59 men. Mean age was 60.8 +/- 17.9 (13 87). Mean FCG (64.7 +/- 27.4) and mean DC (68.4 +/- 32.6) were not significantly different and a correlation between them was found (r = 0.68; p < 0.001). Using PS to estimate FCG the correlation coefficient was increased to 0.75 (p < 0.001). DC and FCG using PT or PS correlated inversely with age (r = 0.59; r = 0.53; r = 0.66, respectively; p < 00.1). In a cluster analysis model we could find that for extremes of renal function FCG overestimated (DIF = -10.4 +/- 13.3) or underestimated (DIF = 29.8 +/- 29.7) DC. The main influence for the difference between the two methods was body weight (r = -0.69; p < 0.001). The distribution by diagnosis led to two classes of patients for whom DIF was significantly different (p < 0.02), and body weight was the main factor. CONCLUSION: Cockroft Gault formula, although correlating with creatinine clearance, over or underestimates creatinine clearance for extremes of renal function. Age and body weight were the main factors for the differences found between the two methods. PMID- 9951071 TI - [Determination of the international normalized ratio (INR)]. AB - The author explains the nature, reason and practical implications of determining the International Normalized Ratio (INR) for all clinicians and technical personnel, mainly those who work in laboratories. An exhaustive revision is made of the studies performed by the centres involved in thromboplastin calibration exercises to obtain the International Sensitivity Index (ISI) values. PMID- 9951072 TI - [Lupus pancreatitis]. AB - We report the case of a sixteen year old female patient, admitted to a general hospital due to fever, poliarthritis, malar rash and vasculitis. Diagnostic studies confirmed the existence of Systemic Lupus Erythematosus. Shortly after admission, the patient was transferred to an intensive care unit due to severe acute pancreatitis. In spite of its infrequency, the diagnosis of acute pancreatitis must always be considered whenever a patient with SLE presents abdominal pain. The authors emphasise the importance of an early diagnosis of this rare complication, with high mortality rates, and present a brief review of the international literature. PMID- 9951073 TI - [Scientific fraud. A disease we find among ourselves]. AB - Scientific fraud is not a problem exclusive to countries with high scientific development. Fraud does not necessarily mean invention of results, usurpation of ideas, manifest plagiarism or any other kind of serious scientific misconduct. Although more rare in countries where scientific production is more modest, pungent cases of scientific fraud also exist. However, less notorious cases of scientific misconduct are frequent and must be avoided. Examples of these less notorious sins are presented. The seriousness of scientific fraud is not only due to the fact that it may involve public funds, which could have been put to more useful purposes but, above all, because it violates scientific ethics and frustrates the final aim of science, the discovery of truth. PMID- 9951074 TI - [Clinical medicine, research, and medical ethics]. PMID- 9951075 TI - [Therapeutic recommendations. Secondary prevention of cerebral vascular accident]. AB - The guidelines for secondary stroke prevention, graded following available scientific evidence, are presented. Stroke and TIA are defined and the indications for referral established. Basic assessment of stroke patients should include laboratory evaluation, ECG, brain CT, ultrasound examination of the extracranial vessels for events in the carotid distribution, and transthoracic or transesophageal echocardiogram if cardioembolism is suspected. The pharmacological and non-pharmacological reduction of blood pressure and serum cholesterol, stopping smoking and reducing alcohol intake are general measures recommended for secondary stroke prevention, together with healthier life-style changes (eating a Mediterranean type diet and performing regular moderate physical exercise). Concerning antithrombotic therapy, oral anticoagulants are recommended for patients with atrial fibrillation and other high to medium emboligenic cardiac risk conditions. Antiplatelet drugs are recommended for all other survivors of an ischemic cerebral event. Aspirin (75-325 mg/day) is the drug of choice. Alternative antiplatelet agents are clopidrogrel, ticlopidine, dipiridamol or triflusal. They can be used in patients with intolerance or contraindication to aspirin or in high-risk subjects. Endarterectomy of the symptomatic carotid is an additional procedure recommended for patients with ischemic stroke or TIA and carotid stenosis > 80% on the side of the symptomatic cerebral hemisphere. PMID- 9951076 TI - [Ischemia of the anterior vestibular artery (Lindsay-Hemenway syndrome). Review and comments]. AB - INTRODUCTION: The Lindsay and Hemenway syndrome is produced by ischemia in the territory of the anterior vestibular artery and is characterized by an initial episode of acute vertigo followed by benign paroxysmal positional vertigo and decreased or abolished caloric response. OBJECTIVE: To determine the incidence of anterior vestibular artery syndrome in patients with benign paroxysmal positional vertigo. DESIGN: A 3-year retrospective study (January 1994 to December 1996). SETTING: Patients with benign paroxysmal positional vertigo of the Zamora and Salamanca (Spain) health districts seen in two outpatients clinics. STUDY SUBJECTS: Ninety-eight patients with benign paroxysmal positional vertigo. RESULTS: Sixteen patients diagnosed as anterior vestibular artery syndrome were revised (16.3%). CONCLUSIONS: Although the literature is scarce, the incidence of Lindsay-Hemenway syndrome seems to be underestimated. PMID- 9951078 TI - [Epidemiological-clinical study of tinnitus in the ambulatory care setting]. AB - A questionnaire was distributed to 100 consecutive patients who consulted for tinnitus as their main complaint in a general ear, nose and throat clinic. The usefulness of the questionnaire as a tool for quickly obtaining pertinent data about the patientis history was established. Epidemiological and clinical findings that may help the clinician reach a diagnosis, prescribe complementary studies, initiate treatment, and continue follow-up are described. PMID- 9951077 TI - [Value of auditory evoked potentials of the cerebral brainstem in the diagnosis of retrocochlear tumors]. AB - The use of auditory brainstem response (ABR) in the diagnosis of retrocochlear tumoral pathology has been established for years, but the development of magnetic resonance imaging for the same purpose calls for a review of the value of this method. We studied 200 ABR records made to exclude pathology. The results indicate that ABR is useful as a screening method in this type of pathology when carried out in a population with any auditory symptom, although it was not very suggestive. In most positive tests, the presence of pathology is not confirmed. PMID- 9951079 TI - [Role of nasosinusal endoscopic surgery in the treatment of headache and facial pain of rhinogenic origin]. AB - Headaches and facial pain are common complaints. In many cases patients are referred to an otolaryngologist to determine if head pain is sinus related. In the absence of other nasal or sinus symptoms, some rhinogenic headaches can be overlooked or misdiagnosed. A complete history and thorough ENT examination, including nasal endoscopy, with or without coronal CT scans, is the key to the correct diagnosis. Subtle exploratory findings such as minimal inflammatory changes or anatomic abnormalities of the ostiomeatal complex area may cause pressure resulting in facial pain. When medical treatment fails to produce sustained relief, surgery may be considered. Current worldwide thinking firmly supports the endoscopic endonasal approach as a safe and effective form of treatment in patients with nasal and sinus disease. We prospectively assessed 67 patients who underwent FESS for rhinogenic facial pain in the absence of other nasal or sinusal symptoms. The overall success rate was 93%. Only 5.9% of our cases had some minor complications. No major complications occurred. PMID- 9951080 TI - [Beta-lactamase-producing bacteria in recurrent childhood tonsillitis]. AB - Beta-lactamase production by the normal pharyngeal flora could account for the failure of penicillin treatment in patients with recurrent tonsillitis. We studied the microbial flora of tonsils from 22 healthy children (control group) and from 40 children with recurrent tonsillitis who were treated with penicillin. Cultures were made before treatment and repeated 15 days after the first culture. Streptococcus pyogenes was recovered in 25% of the patients in the recurrent tonsillitis group. Beta-lactamase producing bacteria were recovered in 100% of children with tonsillitis and in 86.4% of the healthy children. We found a 65% failure rate of penicillin therapy in recurrent tonsillitis. Our results suggest that beta-lactamase production by pharyngeal organisms does not fully explain the failure of penicillin therapy for recurrent tonsillitis. PMID- 9951081 TI - [Melatonin in palate tonsils with recurrent acute tonsillitis and tonsillar hypertrophy]. AB - Tonsils are a point of contact between the environment and the immune system. The pineal hormone melatonin is influenced by environmental dark-light variations and modulates the immune system. We measured the amount of melatonin present in pediatric tonsillar infectious and obstructive processes. The highest levels of tonsillar melatonin were found in tonsillar hypertrophy and the lowest levels in recurrent acute tonsillitis, with or without hypertrophy. Melatonin has an immunostimulative function and an antiapoptotic effect. The relationship between low tonsillar melatonin concentrations and infection, as well as high melatonin levels and increased tonsillar size is discussed. PMID- 9951082 TI - [Effectiveness of uvulopalatopharyngoplasty in snoring disorders and obstructive sleep apnea]. AB - We studied the effectiveness of uvulopalatopharyngoplasty under general anesthesia and classical surgery in 26 patients treated surgically for chronic snoring (CS) and obstructive sleep apnea syndrome (OSAS). Our technique is a variation of the Fujita and Quesada technique that involves partial resection of the palate and uvula with endonasal microsurgery. The criteria for inclusion were age 35 to 47 years and desire to do without C-PAP or Bi-PAP. This device, although effective, produced poor physical and psychological tolerance. After a postoperative follow-up of 3 years, good results were found in all cases. PMID- 9951083 TI - [Oncologic surgery of the larynx after failure of radiotherapy]. AB - The treatment of early-stage laryngeal cancer using either partial surgical techniques or irradiation still is controversial. The performance of rescue surgical procedures after irradiation is related to increased postsurgical complications and lower survival rates. We made a retrospective study of 73 patients who underwent rescue surgery after failure of radiotherapy in our department in the last 10 years. A statistical analysis was made of the complications and survival rate of these patients in accordance with tumor location and clinicopathological stage compared with patients who underwent surgery alone (n = 435). More rescue surgery was performed for glottic carcinomas (52/73) than for supraglottic carcinomas (21/73). No significant differences were found in the complication rate (23.6%) compared with the control group (19.6%). There was a significant reduction in survival in patients who underwent previous irradiation of supraglottic tumors compared with glottic tumors and the control group. In view of these results, we conclude that irradiation is not a good option as an initial treatment for supraglottic tumors and that the procedure of choice should be surgical. PMID- 9951084 TI - [Effect of extracapsular extension on cervical recurrence and the survival of patients with laryngeal tumors]. AB - The influence of the extracapsular spread (ECS) of metastatic cervical lymph nodes in patients with laryngeal cancer is discussed. The study included 119 patients who underwent surgery between 1984 and 1992 for squamous cell carcinoma of the larynx and lymph node metastasis confirmed by histology. Results were studied from two main aspects: survival and cervical recurrence. The 3-year survival rate was 73.4% in patients without ECS and 28.9% in patients with ECS (p < 0.001). The 3-year local recurrence rate differed significantly: 23.5% in patients without ECS and 58.3% in patients with ECS (p < 0.001). These results showed that ECS had an unfavorable prognostic significance for lymph node metastasis of laryngeal cancer. PMID- 9951085 TI - [Early endoscopic findings of the upper respiratory and digestive tract in patients undergoing translaryngeal intubation for more than 24 hours]. AB - The large number of patients undergoing translaryngeal intubation justifies acquiring full knowledge of the complications that this invasive procedure may produce. The short-term problems that cause immediate complications (esophageal intubation, cuff rupture) are severe and do not escape notice. However, less immediate problems often pass undetected, although their presence may worsen the patient's outcome. Endoscopy allows the condition of the upper respiratory and digestive tract to be examined in order to detect and correct such problems. In this preliminary study, risk factors are analyzed and the lesions are described, classified, and quantified. Forty-seven adult patients were studied prospectively. In the first 24 to 48 hours of intubation, rigid endoscopy was performed under sedation using 0 degree and 30 degrees rigid endoscopes. The high rate of glottic edema (63.8%) was noteworthy because knowledge of this condition can be vital for preventing extubation failure. PMID- 9951087 TI - [Hearing loss secondary to lumbar puncture]. AB - Hearing complaints have been described in patients after lumbar puncture, although other symptoms like headache, nausea, and dizziness can easily obscure hearing disorders. Reduced cerebrospinal fluid pressure after lumbar puncture may explain the origin of this vestibulocochlear dysfunction. Two cases of hearing loss and tinnitus that appeared hours after otherwise uncomplicated diagnostic spinal puncture are reported. The pure tone audiogram showed a 40-50 dB bilateral sensorial hearing loss in the lower frequencies. Hearing recovered and tinnitus disappeared entirely within 7-10 days. Since permanent hearing loss has been reported after diagnostic or therapeutic lumbar puncture, we should be aware of the possibility of this adverse effect. PMID- 9951086 TI - [Foreign bodies in the esophagus]. AB - OBJECTIVE: To study the management (diagnostic and therapeutic) of esophageal foreign bodies. MATERIAL AND METHODS: A retrospective study was made of all rigid esophagoscopies performed for suspected foreign bodies in the esophagus by the otolaryngology department of Marques de Valdecilla Hospital (Santander, Spain) from 1992 to 1996. RESULTS: Rigid esophagoscopy was performed for suspected foreign bodies in 195 patients (121 females, 74 males; age range 2 to 97 years). In 183 cases an impacted foreign body was found. The most frequent location was the upper third of the esophagus (165/85.2%). The most common type of foreign body was fish bones in adults (75/171) and coins in children (7/12). In 145 cases a barium esophagogram was obtained before surgery, which yielded 1 false negative and 8 false positives. In 16 patients flexible endoscopy had failed previously to remove the foreign body. Twelve patients (all adults) had serious complications. CONCLUSIONS: The barium esophagogram and rigid esophagoscopy are still appropriate techniques for managing esophageal foreign bodies. PMID- 9951088 TI - [Cerebral abscess of otogenic origin located simultaneously in the temporal and cerebellar regions]. AB - A 28-year-old male was seen for chronic left ear disease. A brain abscess appeared in the left temporal lobe and later spread to the cerebellum. Diagnosis was clinical and radiological. Intravenous antibiotic treatment resulted in resolution of the temporal abscess on CT. However, a new abscess that appeared in the left cerebellar hemisphere required neurosurgical debridement. The patient's microbiological cultures and history suggested an otological origin. Brain abscess is a serious complication of ear disease that requires early diagnosis and treatment. PMID- 9951089 TI - [Abnormality of the lower cranial nerves as a symptom of Chiari's syndrome]. AB - Dysfunction of the last cranial pairs can occur in some neurological diseases, such as Chiari's malformation. This entity causes herniation of the cerebellar amygdalas through the foramen magnum, producing descent of the brainstem and traction on the lower cranial pairs. This dysfunction occurs in 57-70% of patients with this malformation, which is why the disease may be diagnosed in the ENT clinic. Clinical suspicion of this entity after exhaustive examination of the patient, early disease diagnosis and correct selection of surgical treatment can alleviate major symptoms and prevent neurological complications in some cases. PMID- 9951090 TI - [Subdural empyema as a complication of sinusitis. Association with Streptococcus milleri]. AB - Intracranial complications of sinusitis now are unusual and subdural empyema is even more infrequent. Furthermore, subdural empyema usually is related to sinus infections, particularly those caused by Streptococcus milleri, an anaerobic organism. Although clinical suspicion is fundamental, computed tomography and magnetic resonance imaging are essential for discovering these complications. These studies enable early diagnosis and prompt treatment, thus reducing the high mortality of this disease. We report two cases of subdural empyema secondary to sinusitis in persons without impaired immunity. Streptococcus milleri was isolated in one of them. A review of the literature disclosed that this is the most frequently involved organism, so the empirical selection of antibiotics targeted this organism. PMID- 9951091 TI - [Acute suppurative thyroiditis secondary to fistula of the pyriform sinus]. AB - Acute suppurative thyroiditis is very rare and often related to congenital abnormalities of the branchial pouches or immunodeficiency. A case of acute thyroiditis due to fistula of the left pyriform sinus in a young man with no relevant history is reported. We review the embryology, diagnosis, and treatment of this rare entity. PMID- 9951092 TI - [Granulocytic sarcoma. A case with an unusual location]. AB - An unusual case of granulocytic sarcoma infiltrating the parotid gland of a 17 year-old woman is reported. There was no evidence of acute myeloid leukemia or chronic myeloproliferative disease at time of diagnosis. The myeloid nature of the tumor was discovered with the aid of immunochemistry. The patient responded well to combined polychemotherapy and local radiotherapy. Eighteen months after diagnosis, the bone-marrow biopsy showed no signs of blast infiltration. Granulocytic sarcoma should be considered in the differential diagnosis of malignant tumors of the parotid gland, although it is rare. PMID- 9951093 TI - [Unusual analytical interference caused by benzathine penicillin G]. AB - Benzathine penicillin G is one of the antibiotics most often used in ENT practice. In spite of potential allergic or hypersensitivity complications, the restrictions for its administration are scant and its antibacterial spectrum often coincides with the pathogenic flora of the upper airways. A curious analytical interference secondary to its use was detected in two patients seen in our emergency unit. This phenomenon, not observed with other beta-lactamics or even other penicillins, consisted of a continuous false positive result in the urinary detection of amphetamine and its metabolites that lasted up to 50 days after the antibiotic was administered. This finding not only seems to be specific to the benzathine salt, but also to the enzymoimmunoanalysis used to detect drug abuse. PMID- 9951094 TI - [Outcome of nonspecific right iliac fossa pain syndromes]. AB - One-third of all cases of abdominal pain and a quarter of cases of right iliac fossa pain urgently admitted to hospital leave hospital with no precise diagnosis. Based on a series of 400 patients hospitalised for right iliac fossa pain, comprising 107 cases with no identified aetiology, this prospective study was designed to assess the medium-term outcome of these patients, with or without surgical exploration. 67 cases were reviewed at five years. No major diagnosis was missed. Over this 5-year period, 30 patients (45%) experienced another episode of abdominal pain. Among the third of patients (21 cases, 31%) reviewed for another episode of right iliac fossa pain, 7 were readmitted to hospital, with 5 operations, for histologically confirmed acute appendicitis in 3 cases (5% of the series). The patient and his attending physician must be informed of the nonspecific diagnosis established during the first hospitalisation. There is no significant evidence to suggest a psychological component in the recurrent nature of the pain. Cancer must be formally excluded in patients over the age of 50. When surgical exploration is performed, nowadays by laparoscopy, appendicectomy is recommended. This procedure does not decrease the risk of recurrent pain, but confirms the real absence of histopathological abnormality and decreases the number of subsequent hospitalisations. PMID- 9951095 TI - [Does laparoscopy reduce the incidence of useless appendectomies?]. AB - The aim of this retrospective study is to evaluate the impact of laparoscopic appendicectomy on the incidence of histologically normal appendices. Between 1987 and 1997, 1220 consecutives patients--with an average age of 23.5 years (17-73) and including 841 women (69%)--underwent appendicectomy due to the presence of at least one of the following 3 criteria: right iliac fossa guarding, fever greater than 38 degrees C and hyperleucocytosis greater than 10,000. Patients were divided into two group.: First group with 930 patients were operated by laparotomy and the other group of 355 patients underwent laparoscopic exploration with appendicectomy when macroscopic abnormalities were observed (290 cases). In all cases, the appendices were examined under blind conditions and classified as normal or pathological, and were subsequently classified according to the nature and the severity of the lesions. In group I (laparotomy), the incidence of histologically normal appendices was 25.1%. In group II (laparoscopic), this incidence was only 8.2%. The difference was significant (p = 0.015). In 65 cases (18.3%), a macroscopically normal appendix was left in place: in 55 cases the symptoms were due to another identified cause, however, in 10 cases no cause was found. This study suggests that laparoscopy significantly reduces the number of histologically normal appendices because an other cause is identified more easily provided macroscopically normal appendices are not removed with a small proportion (5-10%) cases of early appendicitis with only mucosal involvement. In the absence of other causes for the symptoms, a three-day course of antibiotics can be tried in order to treat possible mucosal lesions. This approach reduces costs without having any adverse consequences on outcome. PMID- 9951097 TI - [U-shaped free jejunum transplant]. AB - Reconstruction of the oro and hypopharynx has specific difficulties due to their wide diameters. Seven patients underwent reconstruction with a free U-shaped jejunal transplant, after circular pharyngolaryngectomy for hypopharyngeal cancer invading the oropharynx. This transplant included a side-to-side anastomosis between the two limbs of the jejunal loop. This transplant allowed reconstruction of the upper digestive tract after wide carcinologic resection of the pharynx. The U-shaped jejunal transplant facilitated the upper anastomosis, especially at the upper part where the resection involved the oropharynx. It formed a reservoir behind the tongue, and avoided nasal reflux. The best indications are large resections involving the oropharynx. PMID- 9951096 TI - [Repeat surgery for thyroid nodules (excluding cancer and hyperthyroidism)]. AB - Second procedures for recurrent thyroid disease are known to carry a high risk of iatrogenic damage, particularly to the inferior laryngeal nerves and parathyroid glands. This risk has been clearly evaluated for the primary procedure, but is less clearly for second procedures. A series of 117 patients with solitary or multiple cold thyroid nodules were evaluated (excluding those patients re operated for recurrent thyroid carcinoma or goitre associated with hyperthyroidism) to determine the operative risks. The level of transient and permanent recurrent laryngeal nerve palsy was 2.56% and 1.7% respectively. The level of transient and permanent hypocalcaemia was 12.9% and 4.62% respectively. The frequency of re-operation for recurrent disease involving the pyramidal lobe following total thyroidectomy (6 cases) highlights the importance of removing it during the primary procedure. The number of cases of cancer discovered at re operation was 4.3% (5 cases out of 117). PMID- 9951099 TI - [Preoperative treatment of resectable rectal cancer]. PMID- 9951098 TI - [Isolated splenic trauma in adults: value of Resciniti's CT scoring system to define the indications for surgery]. AB - The data of 62 adult patients with isolated blunt splenic trauma were retrospectively analysed to determine the value of a CT score-system in the choice of treatment: nonoperative treatment versus surgical management. 22 patients (35%) without hemodynamic instability presenting with pain localized in the left flank were primarily managed conservatively. 3 of them subsequently required splenectomy. 40 patients (65%) were operated immediately, 32 on the basis of clinical criteria and 8 on the basis of laboratory criteria. 45 patients with no initial haemodynamic disorders were investigated by abdominal CT-scan. Splenic injuries were retrospectively classified according to Resciniti's CT scoring system. 13 patients had a splenic injury score > or = 5.5. All of them were operated, 11 early and 2 after failure of conservative management. According to our study this score > or = 5.5, which concerns 21% of our patients, can be considered to be an indication for surgery; in this case, a conservative approach should not be at tempted, even in the absence of immediate clinical and laboratory operative criteria. PMID- 9951100 TI - [Pediatric anesthesia: why and form whom?]. PMID- 9951101 TI - [The place of laparoscopy in pediatric surgery]. AB - The development of laparoscopy in children is designed to decrease the risks of this technique by respecting certain rules (particularly open laparoscopy). The indications are beginning to be well defined for certain frequent diseases (appendicitis, impalpable testes, gastro-oesophageal reflux) suitable for prospective studies, but remain much more subjective in other indications (splenectomy, lumboscopy) due to the limited paediatric series. PMID- 9951102 TI - [Inguinal hernia in the infant]. AB - The inguinal hernia repair account among surgical procedures the most frequently performed in children. It represents a flawless example of the paediatric specificity of a common reputed pathology. Its diagnosis especially in the young children can be delicate justifying thus a systematic tracking during the clinic examination. The pathology of the vaginalis processus is varied and the associated anomalies recognition especially the presence of an undescended testis has to be detected. Inguinal incarceration is often inaugural in infants. Consequences concern in the first place the testicular blood supply before to interest the vitality of the incarcerated intestine whose ischemic suffering will be more delayed. Systemic and early herniotomy has become recommended because of improvement of anesthetic and surgical safety in all ages. Risks of abstention today exceed these of a precocious operation with all respects of surgical and anesthetic criteria required according to the age of the child. Despite inguinal hernia repair is one of the operations on basis in general surgery, its realization in children requires to be warned of the specificity of this act. The dissection of the spermatic cord exposes to a traumatic damage of vas deferens which must be avoided by an appropriate technique. PMID- 9951103 TI - [Treatment of blunt splenic trauma in children]. AB - The conservative management of blunt splenic trauma in children has been generally accepted for about twenty years, in order to avoid serious post splenectomy infectious complications. The objective of this study was to evaluate the results of conservative management. PATIENTS AND METHODS: 21 cases of blunt splenic trauma were treated between 1 January 1991 and 31 December 1995. Eleven cases were isolated and 10 were associated with other visceral, musculoskeletal or head injuries. The lesion consisted of subcapsular or intraparenchymal haematoma in 8 cases and ruptured spleen in 13 cases. All children were initially managed conservatively, except in the case of unstable haemodynamic parameters after resuscitation, perforated viscus or secondary complication. RESULTS: Emergency surgery for blunt splenic trauma was never required over this 5-year period. Four children required secondary surgery, 2 for left renal lesion, 1 for pancreatic pseudocyst and 1 for epidermoid cyst of the spleen discovered incidentally at the time of the trauma (partial splenectomy). No associated bowel perforations were observed. Four children were transfused, 3 for an associated visceral lesion and only once because of ruptured spleen. The mean length of hospital stay was 18.2 days in the case of isolated rupture and 28.7 days for a ruptured spleen associated with other lesions. No immediate or long-term complications were observed with a mean follow-up of 6 months. CONCLUSION: Conservative management of blunt splenic trauma is possible under good conditions of security and total splenectomy was never required. The blood transfusion rate was very low. PMID- 9951104 TI - [Hepatic trauma: pediatric features]. AB - Conservative management of hepatic trauma has been demonstrated to be effective in children. However, surveillance of these patients in a specialized paediatric surgery unit is essential because of the possibility of rare, but unavoidable complications. The authors review the 20-year experience of conservative management of hepatic trauma reported in the literature. PMID- 9951105 TI - [Management of Hirschsprung's disease during the neonatal period]. AB - Hirschsprung's disease is one of the common est causes of neonatal intestinal obstruction. Despite progress in the identification of genetic mutations, the pathogenesis of Hirschsprug's disease is not completely resolved. The management consists of septic complications of treatment, and a variable "pull-through" procedure, immediately or at a later date. Long-term follow-up is an important component of patient care. PMID- 9951106 TI - [Management of acute swollen scrotum in children]. PMID- 9951107 TI - [Impalpable ectopic testis: an excellent indication for laparoscopy, but by a specialist]. PMID- 9951108 TI - [Correction of hypospadias. What is new in the past 10 years?]. PMID- 9951109 TI - [Laparoscopic appendectomy. A simple, reproducible mesoappendix hemostasis technique]. PMID- 9951110 TI - [Jejunal duplication in adults. Case report]. PMID- 9951111 TI - [Duodenal duplication in adults. Laparoscopic treatment]. AB - The authors report a case of duodenal duplication in a adult. This lesion is rare. The clinical course is dominated by a risk of cancer. These lesions should be recognized to avoid a mutilating excision procedure in favour of a conservative procedure. The originality of this case is the laparoscopic approach which confirmed the diagnosis by the elective implantation on the first part of the duodenum. This approach, by mobilisation of the duodenum, allows excision by a very short laparotomy. PMID- 9951112 TI - [Laparoscopic treatment of a diaphragmatic hernia through the foramen of Morgagni in children. A case report and review of eleven cases reported in the adult literature]. AB - A new case report of laparoscopic repair of a diaphragmatic hernia through the foramen of Morgagni in a 11-year-old boy with Down's syndrome is described. The review of 11 other cases in the adult literature illustrated the various aspects of this laparoscopic approach. PMID- 9951113 TI - [Post-traumatic flank hernias. Report of two cases]. AB - We report two patients who developed a post-traumatic flank hernia manifested several months after road traffic accidents. The diagnosis was missed and established later when a swelling appeared in he flank. CT Scan found a large parietal defect. Treatment by implanting a mesh of non-absorbable material was successful. Post-traumatic flank hernias are rare. The diagnosis may be clinically difficult and is mainly based on CT scan examination. A delayed repair is recommended. PMID- 9951114 TI - [Reflexions on gifts from the pharmaceutical industry]. PMID- 9951115 TI - [Comparison among patients considered candidates for radical prostatectomy in academic institutes in different countries]. AB - OBJECTIVE: Radical prostatectomy is performed in potentially curable prostatic cancers, but surgical indication might somehow depend on the idiosyncrasies of a population. Herein we compare the characteristics of patients undergoing radical prostatectomy in teaching University Hospitals of different countries. METHODS: We conducted a retrospective review on 250 consecutive patients who underwent radical prostatectomy before January 1997 in five teaching University Hospitals in Europe (Spain, Sweden, Switzerland, Turkey) and the United States (Detroit, MI). Clinicopathological data were recorded and compared, and a questionnaire investigated whether patient and physician attitudes towards surgery differed. RESULTS: The number of surgeries per month at each institution ranged from 0.9 to 10 and the proportion of newly diagnosed patients that undergo surgery from 0.14 to 0.36. The Kruskal-Wallis test revealed both median age and preoperative prostate-specific antigen (PSA) levels were different between groups. Similarly, despite standardized surgery and histologic work-up, differences in the detection of extracapsular invasion and the rate of detectable PSA after surgery were observed between institutions. Diagnosis in the Swedish and Swiss groups was more often based on digital rectal examination, while the rest were more confident with transrectal ultrasound. Doctors at some institutions were more inclined to recommend radical surgery, either by not mentioning or disapproving other therapeutic strategies. The proportion of patients who said they would elect surgery again ranged from 72% to 92%, and the proportion of doctors who said they would perform surgery again ranged from 78% to 100%. Patients' and doctors' degree of satisfaction with the decision made were also different. CONCLUSIONS: (i) Candidates for radical prostatectomy in teaching hospitals of several countries are different. Might therefore have practical implications on the design of clinical trials and the interpretation of the results of treatment. (ii) Patient and physician acceptance of surgery varies according to countries and is more established firm in those countries where it is more frequently performed. PMID- 9951116 TI - [Management of the complications of ureterointestinal reimplantation in urinary diversion]. AB - OBJECTIVE: To analyze our experience in the management of complications of ureteroenteric reimplantation in patients undergoing urinary diversion by endourological techniques or open surgery, in order to identify a useful algorithm that takes the oncologic prognosis into account, as well as the probability of success. METHODS: A retrospective study was conducted on 136 patients who had undergone urinary diversion from 1987-1998. Of these, 126 had transitional cell carcinoma, two had infiltrating carcinoma, two had a benign condition and 6 had undergone urinary diversion for patient comfort without cystectomy. The following techniques were utilized: cutaneous ureteroileostomy or Bricker technique (104 patients), Mainz neobladder (10 patients), ileal neobladder (15 patients), colonic conduit (5 patients) and cutaneous ureter (2 patients). RESULTS: Overall, 56 patients (41%) had some type of alteration at the ureteroenteric reimplantation site, but only 36 (26%) required intervention. The reimplantation techniques utilized were: the Bricker direct ureteroileostomy (26 patients), Le Duc (6 patients), Leadbetter (3 patients), and the direct cutaneous technique (1 patient). Patient mean age was 67 years (range 53-80). There were 35 males and one female. Seven patients required immediate reimplantation due to a persistent urinary fistula and 29 had late obstruction (more than 3 months), accounting for 21.3% of the cases undergoing urinary diversion. The antegrade endourological approach was utilized in 24 patients (5 nephrostomy alone and 19 stent or balloon dilatation). Dilatation was performed palliatively in 6 cases with extensive tumor spread. Permanent success was achieved in 5 cases (38%) and in spite of the initial success, there were 4 reobstructions. Open surgery was performed in 24 patients (66% of the complicated reimplantations); 5 of these patients had another pathology that warranted laparotomy, 7 required reimplantation early due to a fistula and two patients with a nonfunctioning kidney underwent nephrectomy. Ureteral replacement using the ileum was performed in 4 patients and direct reimplantation to the primary loop was performed in 6 patients. Good surgical results were consistently achieved. CONCLUSIONS: The complication rate of ureteral reimplantation is high in patients undergoing urinary diversion. Endourology has an important role in these cases, particularly in patients with a poor prognosis. Surgery achieves the best results. Although they may entail difficulty, complex cases such as extensive ureteral necrosis can be managed successfully. PMID- 9951117 TI - [Testicular torsion before 6 hours. I]. AB - OBJECTIVE: To analyze the characteristics of testicular torsion within the first 6 hours, and to emphasize the need for early diagnosis and treatment. METHODS: The records of 33 patients treated for testicular torsion within the first 6 hours were reviewed. We evaluated the reason for consultation, previous patient history, clinical features, urinalysis findings, diagnostic methods and surgical findings. RESULTS: The most common reason for consultation was scrotal pain. Twelve patients had a previous history of ascending testis. Urinalysis was normal in 25 patients. Diagnosis was based on the clinical findings. Thirty-two testes were preserved. CONCLUSIONS: Diagnosis of testicular torsion within the first 6 hours are usually based on the clinical findings. Early treatment can achieve testicular viability. PMID- 9951118 TI - [Testicular torsion between 6 and 12 hours. II]. AB - OBJECTIVE: To analyze the characteristics of testicular torsion between 6-12 hours. METHODS: The records of 47 patients treated for testicular torsion within 6-12 hours were reviewed. We evaluated the reason for consultation, previous patient history, clinical features, urinalysis findings, diagnostic methods and surgical findings. RESULTS: The reason for consultation was scrotal pain in 42 patients; 17% of the patients had a previous history of ascending testis. Orchidectomy was required in 17% of the patients. CONCLUSIONS: The need for performing orchidectomy is higher in cases with testicular torsion diagnosed between 6-12 hours. The results of urinalysis are generally normal. The clinical findings and the diagnostic techniques are useful in making early diagnosis and instituting early treatment. PMID- 9951119 TI - [Testicular torsion after 12 hours. III]. AB - OBJECTIVE: To analyze the damage caused by testicular torsion after 12 hours. METHODS: The records of 59 patients treated for testicular torsion after 12 hours were reviewed. We evaluated the reason for consultation, previous patient history, clinical features, urinalysis findings, diagnostic methods and surgical findings. RESULTS: The reason for consultation was scrotal pain in 81% of the patients: 61% were referred to the left testis. Seventeen percent of the patients had a previous history of ascending testis. Scrotal US was useful in making the diagnosis in 92% of the cases. CONCLUSIONS: Testicular damage or loss can occur if testicular torsion is diagnosed after 12 hours. The importance of early diagnosis and treatment is emphasized. PMID- 9951120 TI - [Tumors of the upper urinary tract: epidemiology, clinical, and diagnosis]. AB - OBJECTIVE: To review the epidemiological, clinical and diagnostic aspects of upper urinary tract tumors (UUTT). METHODS: The clinical records of 105 patients with UUTT were reviewed. There were 114 functioning units in total. Data on distribution according to sex, age at presentation, involved side, focality, localization, association with bladder tumor, risk factors, clinical features, radiological and histological findings were analyzed. Descriptive statistical analysis was performed and the means and frequency rates were estimated. RESULTS: Of the 105 patients, 88 (83.8%) were male and 17 (16.1%) were female, accounting for a male to female ratio of 5.1:1. The mean age was 68.3 +/- 10.5 years (range 24-88). The tumor involved the left side in 52 cases (49.5%), the right side in 49 cases (46.6%) and 4 cases (3.8%) had bilateral involvement; 84 (80%) were unifocal and 21 (20%) were multifocal. The pyelocaliceal region was compromised in 41.2% (47/114) of the functioning units, the lumbar ureter in 14% (16/114), the sacral ureter in 7% (8/114), the pelvic ureter in 28.9% (33/114) and the entire upper urinary tract in 8.7% (10/114). UUTT was associated with a bladder tumor in 60.9%. The bladder tumor and UUTT presented simultaneously in 26 cases (29.8%). The bladder tumor presented before the UUTT in 35 cases (40.2%) and in 26 cases (29.8%) it presented after. Smoking was found to be the most important risk factor. Hematuria was the most common reason for consultation (67.6%), followed by flank pain (23.8%), and 13.3% were asymptomatic. The most common urographic finding was a filling defect (46.4%), followed by loss of function (36.8%) and hydronephrosis (20.1%). Loss of renal function was observed in 66% of the cases with metastasis. Histologically, 99% were transitional cell carcinoma, basically moderately differentiated (68.8% grade II) and non infiltrating (58.6% pTa-pT1). CONCLUSIONS: Our findings are largely in agreement with the data published in the literature, although we have found a very high incidence of UUTT associated with bladder tumor in our series. PMID- 9951121 TI - [Transitional cell bladder carcinoma in patients younger than 40 years of age]. AB - OBJECTIVE: The clinical and pathological characteristics of bladder cancer in young patients were analyzed to determine if patients with bladder cancer under the age of 30 have a better prognosis than older adults and if transitional cell carcinoma of the bladder in patients aged 30 to 40 years has a similar behaviour to that observed in the higher risk population. METHODS: A retrospective review of transitional cell carcinoma of the bladder in patients less than 40 years old that had been treated between January, 1993 to August, 1997 was undertaken. RESULTS: We found 8 patients (5 men and 3 women) with urothelial tumor, accounting for an incidence of 4%. Four cases were diagnosed and staged TaG1, 2 T1G1 and 2 T1G2. Recurrence was observed in one case (12.5%) and progression in none. CONCLUSIONS: Transitional cell carcinoma of the bladder in patients under the age of 40 is usually associated with low grade and low stage tumors. The foregoing finding is certainly observed in those aged less than 30 years old. Bladder cancer is relatively rare in this age group, although we have found a higher incidence than that reported elsewhere. Treatment and follow-up depend on tumor grade and stage, regardless of age. PMID- 9951122 TI - [Renal transplant in patient older than 65 years of age]. AB - OBJECTIVE: To analyze the outcome of renal transplantation in patients more than 65 years old. METHODS: From 1991 to 1997, 83 renal transplants were performed in patients aged over 60 years at our institution; 20 of these patients were more than 65 years old. The control group comprised graft recipients under than age from the 477 cases that had undergone transplantation during the period 1980 1996. Graft donor selection was done according to standard practice. The immunosuppression protocol changed over time; 5 patients received triple therapy and another 15 patients received quadruple sequential immunosuppression therapy. RESULTS: The mean age of the recipients was 66.8 years (range 65-72); 9 patients required dialysis after renal transplantation. Patients aged over 65 years had a 94% survival at 6 months, 88% at 12 months, and 88% at 48 months, whereas the survival rates for the control group were 96%, 95% and 87% for the respective time periods. Graft survival was 95% at one month, 90% at 3 months and 74% at 48 months versus 93%, 87% and 78% for the control group. CONCLUSION: Patients more than 65 years old with chronic renal failure and who are on dialysis can benefit from renal transplantation. PMID- 9951123 TI - [En bloc renal transplant from infant donors to adults]. AB - OBJECTIVE: To analyze the medium-term outcome of en bloc transplantation of pediatric kidneys into adult patients, including the incidence and type of surgical complications. METHODS: From November 1991 to December 1997, we performed 37 en bloc transplantation of pediatric kidneys into adult patients. The kidneys were harvested from donors less that 3 years old and/or weighing 15 kg. The mean follow-up was 24 months. Grafting was achieved by end-to-side anastomosis of the donor cava to the receptor external iliac and the aortic patch to the external iliac artery. RESULTS: Three grafts failed, probably due to hilar torsion; the remaining were initially functioning well. Seven transplant removal were performed; 6 were due to thrombosis. The actuarial graft survival was 89.1% at one month, 80.83% at 12 months and 80.83% at 24 months. CONCLUSIONS: The medium-term results of en bloc transplantation of pediatric kidneys into adult patients were excellent and demonstrate the efficacy of this type of grafts. Arterial and venous thrombosis were the most important complications, quantitatively and qualitatively. PMID- 9951124 TI - [Urodynamic models in the analysis of pressure-flow studies in the adult male]. AB - OBJECTIVE: To determine which urodynamic model best describes lower urinary tract dynamics during the voiding phase. METHODS: A pressure-flow study was conducted in 211 adult males. The urodynamic data from the pressure-flow study were modelized to a multivariate analysis with a descriptive design. Three descriptive models of urethral resistance were proposed: a linear model that consisted of the detrusor pressure at the end of voiding and the pressure-flow plot slope, and two quadratic models with one parameter [urethral resistance average (URA)] or two parameters [opening detrusor pressure and passive urethral resistance ratio curvature (PURR)]. Bladder contractility was defined by two parameters: power at maximum flow rate (Pw) and maximum power/bladder surface (Wmax). Voiding volume was included in all models as control variable. The best model was defined as that which explains a higher percentage of observed maximum urinary flow rate, the most widely utilized datum in the urodynamic studies of the adult male. RESULTS: The model that consisted of the URA and Pw was found to be the best. We observed an interaction between URA and voiding volume (at higher voiding volume the decrease of the maximum urinary flow due to URA was found to be greater). CONCLUSIONS: The URA was found to be the parameter that best describes urethral pressure. Variations in the maximum urinary flow rate is better described by the Pw than by the Wmax. PMID- 9951125 TI - [Pressure-flow studies in the diagnosis of micturition disorders in the female]. AB - OBJECTIVE: To determine the utility of the pressure-flow studies in the diagnosis of voiding dysfunction in women. METHODS: A case-control study was conducted on 80 women. These subjects were divided into two groups: 24 controls with a maximum flow percentile greater than or equal to 50 and no residual volume, and 56 cases with a maximum flow percentile less than or equal to 10. The clinically and statistically significant parameters of the pressure-flow study were entered into a multiple regression logistic equation as explanation variables of voiding dysfunction. RESULTS: The clinical variables that influenced voiding dysfunction were age and the presence of stress urinary incontinence. The urethral resistance average (URA) was found to be the only significant urodynamic parameter. Patients with stress urinary incontinence showed a lower probability of voiding dysfunction. Age and URA directly correlated with the probability of voiding dysfunction. CONCLUSIONS: The URA was found to be the only significant urodynamic parameter. The contractility parameters [power at maximum flow (Pw) and maximum power per bladder unit surface (Wmax)] were not found to be useful as detrusor contractility index in women. PMID- 9951126 TI - [Primary leiomyosarcoma. A rare tumor of the adrenal gland]. AB - OBJECTIVE: To report on a rare case of primary leiomyosarcoma of the adrenal. To our knowledge, this is the fourth case reported in the literature. METHODS: A patient with primary leiomyosarcoma of the adrenal gland is presented. The clinical features are described, and the diagnostic and therapeutic aspects of this rare primary mesenchymal tumor are discussed. RESULTS/CONCLUSIONS: The aggressive nature and the poor prognosis of this rare tumor type are emphasized. PMID- 9951127 TI - [Partial nephrectomy in partially differentiated cystic nephroblastoma]. AB - OBJECTIVE: To report on a case of cystic partially differentiated nephroblastoma in an adult female patient that was treated by partial nephrectomy. METHODS/RESULTS: A 21-year-old female patient with multicystic lesions was submitted to partial nephrectomy involving the lower pole of the right kidney. The presence of embryonal blastema in the septae that separated the cysts was diagnostic of cystic partially differentiated nephroblastoma. CONCLUSIONS: Cystic partially differentiated nephroblastoma can be considered to be a well differentiated variant of nephroblastoma (Wilms' tumor). Due to its benign nature, treatment is by conservative renal surgery, if technically possible. PMID- 9951128 TI - [Exophytic renal angiolipoma versus retroperitoneal liposarcoma]. AB - OBJECTIVE: To report a case of exophytic renal angiomyolipoma mimicking a retroperitoneal liposarcoma on magnetic resonance imaging. METHODS: A large, palpable abdominal mass was incidentally discovered during routine physical examination in a 61-year-old, hypertensive woman. A CT scan disclosed a retroperitoneal mass, 17 cm in diameter, adjacent to the kidney. The MRI findings were diagnostic of liposarcoma. The tumor was resected en bloc. RESULTS: The histopathological findings demonstrated angiomyolipoma. CONCLUSIONS: Exophytic angiomyolipoma can mimic retroperitoneal liposarcoma on MRI. PMID- 9951129 TI - [Bladder carcinosarcoma: chondrosarcoma plus urothelial carcinoma]. AB - OBJECTIVE: To report an additional case of bladder carcinosarcoma. METHODS: An 87 year-old patient was admitted with a one-year history of gross hematuria. Ultrasound evaluation showed a bladder tumor and at cystoscopy a 4 x 3 cm polypoid, broad-based mass was found on the posterior wall of the bladder, surrounded by a multifocal papillary tumor. RESULTS: The tumor was resected transurethrally. Histologically, the tumor was composed of chondrosarcoma and urothelial sarcoma. Immunohistochemically, the sarcomatous elements stained strongly with vimentin and the carcinomatous cells were strongly positive for keratin. CONCLUSIONS: The foregoing findings support the view that these neoplasms are true carcinosarcomas. PMID- 9951130 TI - [Testicular epidermoid cyst]. AB - OBJECTIVE: Benign tumors account for less than 1% of testicular tumors and the incidence is even lower in children. A rare case of epidermoid cyst of the testis in a child is described. The differential diagnosis and treatment options are discussed. METHODS/RESULTS: A case of unilateral epidermoid cyst of the testis in an 11-year-old boy is presented. The clinical and diagnostic aspects are discussed. Definitive diagnosis could be made only after surgical excision. CONCLUSIONS: Pathological analysis of the entire testis is warranted to make the definitive diagnosis of epidermoid cyst. However, preservation of the testis can be considered, particularly in those cases with bilateral involvement, if supported by solid, consistent diagnostic evidence, including intraoperative biopsy. PMID- 9951131 TI - [Fournier gangrene: our experience]. AB - OBJECTIVE: Fournier's gangrene is a necrotizing fasciitis involving the genitoperineal region caused by the synergistic action of aerobic and anaerobic pathogens. It is a rapidly progressing disease and carries a high mortality. Our experience with Fournier's gangrene is presented. METHODS: Herein we describe 11 cases of Fournier's gangrene that were diagnosed and treated from 1991 to 1996. The most important predisposing factor was diabetes mellitus and the most common triggering factor was a perianal condition. RESULTS/CONCLUSIONS: The survival rate was high (81%) and can be ascribed to early diagnosis, aggressive and rapid surgical treatment with debridement, resection of the necrotic areas, drainage, simultaneous broad spectrum antibiotic therapy and frequent local treatment. PMID- 9951132 TI - A long follow-up on prostate specific antigen density and prostate biopsy. AB - OBJECTIVE: To determine prostate specific antigen density (PSAD) in a risk population without evidence of prostatic cancer, and to assess the long-term usefulness of PSAD as a parameter for determining the need for a prostatic biopsy in patients with a normal digital rectal examination (DRE) and transrectal ultrasound (TRUS). METHODS: The records of 582 patients referred to the clinic between February, 1992 and February, 1994 were studied retrospectively. All these patients with lower urinary tract symptoms (LUTS) were evaluated based on the following parameters: digital rectal examination, serum PSA levels, prostate volume measured using transrectal ultrasound and PSAD. Prostatic biopsy was performed on 431 patients who had a serum PSA level greater than 4.0 ng/mL. A total of 299 patients (69.3%) had PSA levels between 4.0 and 10.0 ng/mL and represented the target population. The study had two parts, in the first one cancer was diagnosed just by one biopsy and in part II, the patients with negative biopsy in part I were followed for a two-year period and required 2 or 3 biopsies for diagnosis. Of the total of patients who had a negative prostate biopsy in part I of the study, 269 were followed for a period of two years with repeated prostate biopsies. RESULTS: Overall prostate cancer was detected in 22/299 (13.9%) patients, 6/105 (5.7%) with PSAD up to 0.15 and 16/194 (8.2%) with PSAD over 0.15 (p = 0.569). CONCLUSION: PSAD is a useful indicator in decreasing the number of negative biopsies in patients with benign prostatic hyperplasia. However, in a long-term follow-up the PSAD (cutoff level 0.15) was unable to predict which patients had a positive biopsy. According to our results, 5.6% of patients with prostate cancer will be missed using the PSAD criteria. PMID- 9951133 TI - Physiological anthropology and the Internet. AB - The Internet is the greatest computer network with many services like Web, FTP, Gopher, E-mail Discussion Groups, and Usenet Discussion Groups, that provides a rapid and the cheapest exchange of information. The benefits to anthropologists of using the Internet are growing rapidly, as the Internet becomes easier to use and ever more anthropological resources become available on line. Physiological anthropology is concerned with the evolution and biological features of human population and it's sources on the Internet are growing continuously. However, in that enormous number of data, is not easy to find a needed information. Currently, number of indexed physiological anthropology related sites on Web only is 233990 (October 98). This paper provides informations about Internet and needed hardware and software for using it. It also describes and lists the most important physiological anthropology addresses, together with physiological anthropology-related journals on the Internet, as well as the ways of searching them. PMID- 9951134 TI - Computer assisted densitometric image analysis (CADIA) of bone density in periradicular bone defects healing. AB - CADIA can only be performed on geometrically standardized images converted in Al equivalents. The aim of this study was to develop the ability of the new CADIA software to quantify bone density on dental radiographs without previous standardization. A total of 36 examines with periradicular lesions were treated surgically, the defects were filled with Hydroxylapatite and followed up for 1, 6, and 12 months. Before and after surgery the operated areas were clinically evaluated using intraoral radiographs, tooth mobility index and relapses. Clinical results revealed satisfactory bone healing in 27 cases and relapses in 9 cases. The radiographs were then digitized with a high resolution CCD camera. Densitometric analysis was done in 10 points at the edge of the bone defect. Correction of geometric and brightness distortions was done with mathematical manipulation from three referral points positioned at the same place on each radiograph. Density values observed no bone loss in 23 cases and loss of bone in 13 cases. The differences between clinical evaluation and CADIA were not statistically significant. PMID- 9951135 TI - Computer anchorage analysis of digitized picture of modified typodont. AB - In contemporary orthodontic treatment, the extraction of a premolar is frequently indicated, followed by canine retraction with bodily movement. The main problem is how to prevent the mesial movement of first molars (loss of anchorage) and loss of the space obtained by extraction. The aim of the study was to evaluate the anchorage capacity of posterior teeth using SW (straight wire) appliances after extraction of first premolars and to determine Goshgarian transpalatal arch as anchorage reinforcement. All experiments were recorded by video-camera, and the analogue signal has been digitized and saved on PC. Computer animation visualised the direction and the amount of tooth movement. Very significant loss of anchorage was found (in the control experiment), when molars and premolars were reinforced. No significant difference between the active and non-active transpalatal arch has been perceived in the sense of lateral anchorage stabilization. PMID- 9951136 TI - Metabolic unit of pulp-dentinal complex of human tooth. AB - The change of dentin depends on odontoblast's metabolism (synthesis and secretion), and the result of those cells activity is apposition of dentin: physiological or reactive. Odontoblasts, dentinal tubuli with odontoblastic processus and peritubular zone, they all make metabolic unit of dentin, and they are the major part of circumpulpal dentin structure. Functional activities of the tooth are the base for constant changes during the entire life of circumpulpal dentin. The apposition, and also the resorption of dentinal tissue, can be found as the respond to trauma, pathological conditions, or after the therapeutic interventions. PMID- 9951137 TI - Early antibacterial effect of Pd-Ag dental alloy on aerobic and microaerophilic flora in oral cavity. AB - Early effect of Pd-Ag alloy on aerobic and microaerophilic flora from healthy oral cavity was studied. Normal microbial flora was sampled from saliva, dental plaque and gingival crevice from healthy individuals without any prosthodontic appliances or periodontal diseases. Such samples were inoculated into liquid media and were left in thermostat (37 degrees C) in aerobic condition. In some samples one or two sterile Pd-Ag alloy pieces were inoculated, while some samples were left without that pieces to be a control group. Both were kept in a thermostat for 24 and 48 hrs and after that were examined for bacterial dehydrogenic activity to reveal the amount of active bacteria in a sample. Dehydrogenic activity was registered after incubation of 0.1 ml of 3 phenyltetrazolynchloryde (TTC) into samples. TCC changes a colour of a liquid media because of bacterial dehydrogenic activity and therefore samples were analysed in a spectroscope. Statistical analysis revealed lower bacterial activity (lower TTC distinction) in samples with one or two Pd-Ag alloy pieces than in a control group. These results indicate the existence of initial inhibitory effect of Pd-Ag alloys on aerobic flora in the mouth, which might give space for anaerobic strains to increase ther growth. Presence of periodontal changes in a gingival crevice with Pd-Ag alloy crowns is probably due to anaerobic micro-organisms, as mostly anaerobic strains are responsible for periodontal disease. PMID- 9951138 TI - Infective endocarditis caused by Veillonella of dental origin. AB - The purpose of this investigation was to examine whether Veillonella could cause transitory bacteriemia and endocarditis in both pure and mixed cultures when the port of entrance for infection was made in rats' incisors. Incisors of 54 male Zgr: whistar conventional rats were inoculated with pure culture of Veillonella (18 animals) and with mixed culture of S. mutans and Veillonella (18 animals). Remaining 18 incisors (the control group) were treated with saline solution. The animals were sacrificed after 7, 21 and 52 days respectively. Two positive hemocultures were obtained in mixed infection after 21 days of experimental procedure. Histopatological analysis of endocardial tissue revealed changes in 7 (12.96%) cases. Occurrence of acute endocarditis (one case) and chronical (four cases) ones depended on duration of mixed infections. For chronical endocarditis that appears in two animals with pure Veillonela culture we are at a loss of explanation. In conclusion, on the rats model Veillonella can penetrate into circulation in association with S. mutans via the pulp tissue and could be involved in infective endocarditis. PMID- 9951139 TI - Trichomonas tenax proteolytic activity. AB - In this study, proteolytic activity of Trichomonas tenax collected directly from patient's dentobacterial plaque was examined. Electrophoretic method involving polyacrylamide gels (Commassie Brilliant Blue R-250) and electrophoretic method involving gelatin-containing polyacrylamide gels, have been used to analyse Trichomonas tenax proteolytic activity. The most obvious and the fastest activities were obtained when gels were incubated in pH 4.6; followed by results of incubating in pH 5.6; while in pH 2.8 activity was less effective but still obvious. Proteolytic activities were the most effective in area of protein MW 36 kDa. Different activities of enzymes depending on pH of incubated media indicate the presence of different endopeptidases in cell lysates of protozoon Trichomonas tenax from dentobacterial plaque. PMID- 9951140 TI - Endocrinological status of patients with periodontal disease. AB - The aim of the present study was to determine whether changes in the endocrinologic status occur in patients with progressive forms of periodontal disease and, if so, what their role is. For this purpose the function of hypophysis, concentration of pituitary and accessory gland hormones, parathormone, calcium, phosphorous, glucose and lipids in blood were determined. The study was carried out in 77 subjects, 37 patients with advanced periodontal disease, and 40 control subjects with normal periodontium. Blood glucose was significantly lower in the study group (p < 0.01%) which was surprising, since increased glucose values are known to favor the development of periodontal disease. Growth hormone was significantly lower in the study group (p < 0.01%). Concentrations of parathormone calcium and phosphorous were also lower in the study group. Among sex hormones, only estradiol was found to have a significantly lower value in the study group (p = 0.92%). Although the values of nearly all hormones were within the reference range, the within-group analysis showed significant differences for some hormones. In general, these results were lower in subjects with advanced periodontal disease. PMID- 9951141 TI - The influence of dental amalgam on the blood count. AB - The purpose of this research was to determine the influence of dental amalgam on the blood count of the holder of amalgam fillings. The experiments were performed on 30 Wistar rats. One group of rats received 8 mg of fragmented dental amalgam daily incorporated in their food during 60 days (group S2) and group S3 received amalgam fillings in their anterior teeth, which remained for 60 days. Both experiment groups (S2 and S3) were compared to one another as well as to control group (S1). From all animals of all experiment groups blood samples were drawn during the experiment in particular periods and complete blood count and differential blood count was performed. The findings of particular indicators of the complete blood count and differential blood count of all experiment rats groups S1, S2 and S3 do not deviate from the physiological values regarding age and sex of the observed animals. PMID- 9951142 TI - Taurodontism in Down's syndrome. AB - Forty-three pantograms of the subjects with Down's syndrome were examined for the diagnosis of taurodontic teeth, grade of taurodontism, sex distribution and individual tooth involvement. Taurodontic teeth were found in 55.8% of the subjects, 32.6% females and 23.2% males. Second molars were most frequently affected (53.2%), followed by first molars (40%) and third molars (6.5%). The mesotaurodontic form was the most frequent form of the anomalia (72.5%). Hyypotaurodontic teeth were observed in 9.7% and pyramidal teeth in 17.7% of the cases. Hypertaurodontic teeth were not found. PMID- 9951143 TI - Hypodontia in patients with Down's syndrome. AB - The aim of this study was to assess the prevalence of hypodontia in subjects with Down's syndrome. A group of 112 subjects with cytogenetically confirmed diagnosis of Down's syndrome, aged 12-36 years were examined. Hypodontia of the permanent teeth has been established on the basis of dental examination and orthopantomogram analysis in all cases. Hypodontia was present in 38.6% patients. Upper lateral incisors were most commonly missing. In patients with Angle class I, hypodontia most frequently referred to upper left lateral incisors, upper left first premolars and lower left second premolars. In patients with Angle class II, lower second premolars and upper incisors were most commonly affected by hypodontia. In patients with Angle class III, hypodontic findings more frequently referred to the maxilla as compared to mandible. PMID- 9951144 TI - Characteristics of oral lichen in the Croatian population. AB - Oral lichen ruber (OLR) is a chronic, recurrent disease with a worldwide prevalence of 0.9%-2.2%. In Croatia, the disease has been on a constant increase over the last 10 years, and its prevalence has reached the upper limit. The aim of the study was to identify OLR specificities in a Croatian population. The study included 100 subjects, 84 women and 16 men, mean age 53 +/- 13.88 years, with recurrent OLR. Results showed a four-fold prevalence of OLR in women as compared to men. In women, the disease was found to develop later than in men. Oral changes indicated the reticular form of the disease in 62% and erosive in 33%, whereas all other types were present in 5% of study subjects. Systemic disorders underlying OLR were found in 93% of study patients, predominantly isolated or in combination. Pathologic values of laboratory tests were recorded in 23% of study subjects. Significant differences were obtained in OLR associated with gastritis and diabetes mellitus (p < 0.05), and with gastritis and cholecystopathy (p < 0.001). Increased values of bilirubin (p < 0.01), triglycerides (p < 0.01) and blood glucose (p < 0.001) were recorded in men. The level of total lipids was significantly higher in OLR associated with cholecystopathy (p < 0.05). Accordingly, the occurrence of OLR in the Croatian population was found to be most commonly associated with the hepatobiliary system diseases, followed by gastric disorders and diabetes mellitus. PMID- 9951145 TI - Natural killer cells in oral lichen ruber. AB - NK-cells are one of main indicators of nonspecific and innate immunity. Disorder of NK-cell functional activity can result with autoimmune diseases and it can suppose that every disorder has significant role in pathogenetic mechanisms in OLR, like oral mucocutaneous autoimmunity disease. Result of NK cells function, like indicator of innate immunity condition, can be very interesting in patients with OLR. Examination of NK-cell functional activity and their total count in peripheral blood of patients were spended, which included 38 patients. Examination of total NK cell count in peripheral blood and their activity spended by method described by Rabatic at al. Results showed statistically significant correlation with control groups in all functional activity, NK cell to target cells, in ratio 25:1, 50:1 and 100:1 (E:T) %l. Statistically significant result of lower NK cells functional activity, and total NK cell count in peripheral blood in patients with OLR, refer to alteration of innate immunity persons with this recurrent oral disease. That disorder can have important role in pathogenetic mechanisms in beginnings of OLR. PMID- 9951146 TI - Oral lichen planus and HLA A. AB - Oral lichen planus (OLP) is autoimmune disease that appears on the oral mucosa only, or in combination with skin lesions. The occurrence of squamous cell carcinoma in areas of lichen erosions makes it necessary to follow up patients suffering from chronic lesions. Prevalence in general population varies from 0.9% to 1.2% and varies in different ethnic groups. It is known that cell-mediated immune mechanisms and genetic factors underline OLP pathogenesis. We tested 50 OLP unrelated patients (5 males) for HLA A and compared them to 1089 healthy controls. OLP patients had 3 times less frequently HLA A w19 and 5 times less frequently HLA A28, compared with controls. Erosive OLP type had 4 times less frequently HLA A11 and 2 times less frequently HLA A26 than plaque form. In conclusion, HLA A w19 and A28 appeared associated with OLP in particular, while HLA A11 and A26 with erosive types of OLP. PMID- 9951147 TI - Oral lichen planus and HLA B. AB - Oral lichen planus (OLP) is mucocutaneous autoimmune disease of still unknown etiology. Among all etiological factors, OLP can be associated with carbohydrate disorders. As it is known that some HLA B and DR 3/4 antigens are cross-linked, we have determined the frequencies of HLA B antigens in group of 50 Croatian patients (5 males) with OLP and compared them with the 1089 healthy controls. Alterations in the frequencies of several HLA B antigens were noted, in particular, the frequencies of HLA B 15 were 4 times higher, and HLA B18 were 4 times lower compared with controls. The OLP patients with carbohydrate metabolism disorders had more frequently HLA B16, B2 and B40 and the patients with OLP without disturbed carbohydrate metabolism had more frequently HLA B5, B7 and BX. HLA B15 and B18 are closely connected with DR 3/4 antigens in diabetes mellitus, so these particular antigens may predispose a person to a lichen planus. PMID- 9951148 TI - Oral lichen planus and HLA DR. AB - Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease, predominantly seen in middle-aged female patients. Histopathologically, OLP includes parakeratosis with T-lymphocyte subepithelial infiltration. In etiology of OLP, chronically liver and biliary diseases, stress-induced hypertension, inheritance and most commonly carbohydrate metabolism disorders including diabetes mellitus are mentioned. Considering the autoimmune nature of the illness and the role of the HLA DR 3/4 antigens in development of diabetes mellitus we hypothesized that the same antigens could play role in the development of OLP. We examined 50 unrelated Croatian patients (5 males) from Institute of Oral Pathology, Faculty of Dental Medicine, Zagreb, with clinical and histopathological diagnosis of OLP. They were all tested for HLA DR and compared with 1089 Croatian controls that underwent the tissue standardization in fathership cases. OLP patients had blood sugar level controlled, and those with HLA DR 3/4 and those with blood sugar level higher then 5.6 mmol/l additionally underwent standard oral glucose tolerance test. Carbohydrate metabolism disorder was found in 13 OLP patients (26%) while 10 of them (20%) had diabetes mellitus type I. This finding is 400 times more frequent than is appearance of diabetes in healthy controls (0.05%) in Croatia. PMID- 9951149 TI - Reduction of epithelial dendritic cells in keratotic lesion of oral lichen planus. AB - The number and distribution of epithelial dendritic cells (EDC) in oral mucosal lesions are variable depending on the degree of epithelial maturation/differentiation and disease activity. Localized absence of EDC might impair mucosal immunologic protection, allow microbial colonization and enhance carcinogenesis. Increased number of EDC during the early stage of oral lichen planus (OLP) suggests their increased antigen-presenting capability and immunologic activity with inflammatory reaction, but their role in the process of keratinization remains unclear. Therefore, the purpose of this study was to determine the number and distribution of EDC in 33 biopsy specimens from lesions of OLP and from 18 control specimens of leukoplakia (LPL) at sites undergoing increased keratinization. Cells were identified immunocytochemically by the presence of antigen CD68 and labeled with acid phosphatase (AP) and alpha naphthyl acetate esterase (ANAE) techniques. Numbers of EDC were expressed per mm epithelial surface length. Significantly more EDC with prominent histoenzymatic activity of AP and ANAE were present in OLP than in LPL. Intense enzymatic activity of ANAE was expressed in EDC of OLP with hyperparakeratosis. In the lesions with increased keratinization the number of EDC was markedly reduced in OLP while in LPL remained unchanged. Reduced number and subbasal redistribution of EDC in OLP suggest diminution of immunologic reaction and disease activity but also increased tissue vulnerability to various antigen challenges. PMID- 9951150 TI - Incidence and distribution of dehiscences and fenestrations on human skulls. AB - The aim of this study was to determine the incidence and distribution of dehiscences and fenestrations of the alveolar plate. The sample used in the study consisted of 163 adult jaw bones (78 maxillae and 85 mandibles) of a recent population from the north-western Croatia. The skulls are part of the skull collection of The Anatomy Institute, Zagreb, Croatia. The number and location of dehiscences and fenestrations for each tooth area above the total number of 2038 teeth were registrated. The total number of 696 (26.67%) dehiscences and 190 (9.32%) fenestrations was measured. Among the maxillary teeth, canines exhibited greatest and most frequent dehiscences and fenestrations. In the mandible, canines were most commonly associated with both defects, too. It was concluded that the canines were most frequently associated with either of the osseous defects. PMID- 9951151 TI - Alveolar bone resorption in the skulls. AB - In this report the quantitative relationship between the alveolar bone and cervical part of the teeth in millenary intervals of human existence is reported. In this study 115 skulls were examined of which 27 belonged to the 1st, 22 to the 10th and 66 to the 20th century. The skulls belonged to persons of both sexes older than 20 years. Each group mentioned was divided into four subgroups according to the age persons (20-29, 30-39, 40-49, 50+). It measured tooth cervical-height index (TCH-index) according to Davies and coll. The resorptive changes on the alveoli are increasing in the older age, the alveolar resorption is greater on the vestibular than interdental side, the higher values of alveolar resorption in the skulls of the 20th century are statistically significant in relation to the skulls from the 1st and 10th century. PMID- 9951152 TI - Comparison of dental maturity between two ethnic groups. AB - Dental maturity is one of the indicators of the craniofacial region growth and development. The aim of the study was to identify and compare dental growth and development in two ethnic groups. The material consisted of 480 orthopantomograms; 240 selected from orthodontic and dental patients from Zagreb (Croatia) and Damascus (Syria) each. Each ethnic group included 120 boys and 120 girls, while the radiographs were classified into 6 groups of 20 each, according to sex and chronologic age (8-13 years). Dental maturity was evaluated by the method of Nolla. The results were statistically analyzed and presented in tables. The subjects from Damascus showed a delay in dental maturity by 1 (girls) to 2 (boys) years compared to the homologous group from Zagreb. The reference values determined in the study may serve as a diagnostic, therapeutic and prognostic tool in the orthodontics and pedodontics of the respective cities. PMID- 9951153 TI - Development of third molars in children in Istria. AB - The aim of this study was to determine the prevalence of third molars in children in Istria aged 7 to 18. The study was performed on 2350 panoramic radiographs of children in Istria that have been analysed and then divided into 7 age groups. Each of these groups consisted of the same number of boys and girls. It has been found that the development of third molars starts earlier in the mandible, and that before the age of 12 there are more third molars in the mandible than in the maxilla (p < 0.01). Nine-year old girls have statistically significantly more third molars than the boys of that age, but twelve year old boys have more than the girls. The differences in the prevalence of third molars between the jaw sides was statistically significant only for mandibles of twelve year old girls. Hypodontia of third molars has been found in 4.5% of boys and 5.8% of girls aged 14 to 18. PMID- 9951154 TI - Orthodontic anomalies in primary and permanent dentition--a longitudinal study. AB - This research has intention to examine the stability and the changes of the Classes from the period of primary to permanent dentition on longitudinally examined subjects. The sample consisted of 246 children (132 boys and 114 girls) with orthodontic anomalies in primary dentition that were not orthodontically treated until the ensuing visit made by the same orthodontist in permanent dentition. 71.9% of the examined children (72.7% boys and 71.0% girls) registered no Class changes within the analysed period. Between boys the falling of the Class I occlusion, from primary to permanent dentition is unsignificant, but between girls Class I occlusion is falling significant and grow Class II malocclusion. In boys 29.2% of changes occurred in Class I occlusion of which 25.0% were brought to Class II while 4.2% to Class III malocclusion. In girls from 32.9% changed Class I occlusion, 28.9% changed into Class II, and 3.9% into Class III malocclusion. The Class II malocclusion during the development of dentition is more stable than the Class I occlusion. PMID- 9951155 TI - Dimensional measurements on the human dental panoramic radiographs. AB - The objective of this study was to evaluate the precision of the horizontal and vertical linear dimensional measurements on orthopantomographic images. Different horizontal and vertical distances denoted by metal markers were measured on 25 dry mandibles. The same mandibles were then positioned in an orthopantomographic machine and their radiographic images were made. Measurements of the same distances were repeated on the panoramic images and compared to the results of the measurements on the dry mandibles. All results were statistically analyzed. The results showed significant difference between the magnification factor listed by the manufacturer and the calculated magnification factors, the latter being closer to 1.00. The study also showed that linear measurements made only on one side of panoramic images of mandibles were close to actual dimensions of dry mandibles, while the measurements which extended across the midline of mandibles were greatly enlarged due to large magnification factors. PMID- 9951156 TI - Modification of the angle of the lower third of the face. AB - Determination of vertical dimension of occlusion by roentgencephalometric method, with the help of the angle of the lower third of the face, has been described in literature. The aim of this study was to modify the angle of the lower third of the face and correlate its determination with reference planes for orientation of casts in the articulators space, to determine mean value and measures of variability of the modified angle in a random sample, and the possibility to use this angle as a control value for establishing the height of the lower third of the face. On a sample of 131 roentgenograms in L-L projection, with teeth in maximal intercuspation, points: N, IS47, THA, SNA, SNP, Xi and Pg were traced down. By the use of this points the angle of the lower third of the face (angle K) was constructed. The values of the angle were measured and statistically analyzed. Mean value of the angle was 48.5 degrees, with standard deviation of 4.41 and coefficient of variation 9.09%. The investigated angle can serve as a control value for determination of intermaxillary relationships and should not be accepted as an strict norm. PMID- 9951157 TI - Morphometrical analysis of main and accessory canals in apical root portion of frontal teeth. AB - Reviewing radiographs may often lead to a wrong conclusion regarding root canal ending (apical constriction) and anatomical apex of the tooth root. Anthropological measurements may help clinicians to understand better root canal ending aberrations in a sense to decide whether to do a revision of the root canal filling or not. The object of this investigation was to examine the deviation frequency, the distance of the major apical foramen from the anatomical apex and occurrence and number of accessory canals in the apical third of the frontal teeth roots. A total of 156 randomly chosen upper and lower permanent incisors and canines, after extraction due to periodontal disease were prepared for the investigation. The access cavity was prepared and root canal therapy was initiated just to prepare endodontic space for methylene blue dye injection. Methylene blue clearly dyed all root canal exits and after that the teeth were cut and examined with a stereomicroscope and a sliding scale. Results indicate that deviation frequency was found in 60.25% of the cases and the mean distance between deviated major foramen and the anatomical root apex was 0.35 mm. Accessory canals were found in 33.33% of the cases in the apex third of the root. Data were statistically elaborated with the method of Chi-square test. PMID- 9951158 TI - Osteointegration of a replanted tooth followed by RVG densitometry. AB - The frequency of dental traumas in children has been increasing. This work reviews a patient aged 9 who had the 2-day old fracture of the root of first permanent central incisor skewed palatinally 3 mm under the bone. The tooth was extracted, its canal filled with calcium hydroxide, and within less than 10 minutes the tooth was replanted and fixed by a metal splint. Daily follow-up did not show either pathological perioodontal changes or subjective pain symptoms. After 3 months the tissue density of both incisors was the same, i.e. the fractured tooth showed entire osteointegration. PMID- 9951159 TI - Histologic difference in epithelial linings between follicular and radicular cysts. AB - The purpose of this study was to identify histologic differences in epithelial linings between follicular and radicular cysts in relation of their development. Linings and surrounding tissues of 25 radicular and 20 follicular cysts from archival paraffin embedded tissues were obtained and stained with haematoxylin and eosin. Radicular cysts showed orthokeratotic 9-14 cell-layer-thick non keratinized squamous epithelium and unspecific chronic inflammatory reaction in connective tissue. Follicular cysts showed 2-4 cell-layer-thick of non keratinized stratified squamous or flattened-low cuboidal epithelium and connective tissue capsule free from inflammatory cell infiltration. PMID- 9951160 TI - Development of bony acetabulum in newborns with developmental hip dysplasia. AB - Trend in the development of bony acetabulum in newborns with developmental hip dysplasia was examined during the first year of life. The study comprised 120 newborns with developmental hip dysplasia. The degree of dysplasia was determined by measuring the acetabular angle (AC) on X-rays of the hips in the anteroposterior projection. The experimental trend curve was most adequate for both the whole group and each subject. The coefficient of trend was assessed by specially designed iterative method. The exhibited trend form allows the extrapolation and prognosis of treatment outcome already after 3-5 measurements of the AC angle. The applied iterative method for the determination of the coefficient of exponential trend iterated rather quickly. The chosen form of the trend curve proved to be adequate for manifestations in which a constant value is expected after a longer period of time. The exponential curve represents a mathematical model of the acetabular development dynamics, with allometric exponents and coefficients of the equation being numerical parameters that define developmental changes. As the AC angle reaches the constant value with the closure of triradiate cartilage, this parameter is an objective measure of the development of bony acetabulum. When assessing the acetabular growth in developmental dysplasia it is necessary to bear in mind that duration, specific position and quantity of newly formed and remodelled bone are determined genetically, and that external factors have a significant influence on the definitive formation. PMID- 9951161 TI - Echosonogrametric diagnosis of developmental dysplasia of the hip. AB - In view of adding to ultrasonographic scanning of the neonatal hip through various projections and in order to improve the measurement and quantification base of the normal and dysplastic neonatal hip, the research was conducted on anatomic hip preparation of full-term still-born baby. The research on a clinical sample covered 600 ultrasonically examined normal and dysplastic hips. Ultrasonographic serial scanning was performed on various planes using linear transducer with 5 and 7.5 MHz and with or without a water pillow. On the clinical sample of the particular group various projections were applied and results compared with projections obtained on anatomic preparation. Concluded was that with several projections frontal sonographic projections tomographic examination of the hip joint could be performed. Better insight of the position of the femoral head at rest in neutral and flexed positions, the relative stability of the hip with motion and stress and the depth and configuration of the bony and cartilaginous portions of the acetabulum could be obtained if, besides frontal sections, cross sections of the hip were used. Sufficient measurement data echosonogrametric parameters were indispensable for an adequate definition of all hip joint structures. PMID- 9951162 TI - Body height and weight and respiratory diseases in skeletal Class II/1 orthodontic patients. AB - The aims of this study were to determine if there is an increased incidence of respiratory diseases in patients with Angle Class II/1 skeletal intermaxillary relationship in comparison to eugnathic patients and if there is a difference of body height and weight between them. The sample consisted of 60 eugnathic subjects and 88 subjects with Class II/1. Girls were examined at an age of 6, 7, 8, 10, 13 and 14 and boys at an age of 7, 8, 9, 11, 14 and 15. All subjects underwent an orthodontic and medical examination in these time intervals. Data about their respiratory diseases as well as those about their height and weight were taken from their medical files in school dispensaries and were statistically analyzed. No statistically significant differences with regard to the frequency of respiratory diseases were found between eugnathic subjects and those with Class II/1. In almost all investigated time intervals subjects with Class II/1 were statistically significantly higher than the eugnathic subjects, but only in the 8-years old male group with Class II/1 the subjects were heavier than others. The results of this study suggest that patients with Class II/1 either have a faster growth pattern or belong to an asthenic constitution type. PMID- 9951163 TI - The tooth reduction and abrasion in a group of elderly home residents. AB - The degree of tooth loss and abrasion was the objective of the study on a group of 73 partially dentate elderly home residents, with particular interest in the type of missing and abraded tooth and the type of the interocclusal contacts according to the Eichner classification. The patients were examined by a dental mirror and a probe. The obtained data of dental status as well as medical and dental history were recorded in a specially designed questionnaire according to the WHO recommendations. The results confirmed the hypothesis about the molars being the most commonly missing teeth, with average values of 4.49 present teeth in lateral section and 5.82 present teeth in frontal section of the dental arch. The Eichner index class III was the most often interocclusal relationship found within 74% of the elderly home residents. Lower teeth were abraded more often than the upper teeth, showing higher abrasion degrees (class 2 and 3). PMID- 9951164 TI - Some periodontological parameters in patients with oesophagogastric passage insufficiency. AB - The aim of this study was to examine the state of oral hygiene (OHI), the presence of tooth calculus and the condition of the gingiva on the group of 101 patient with oesophagogastric passage insufficiency. The control was group of 78 examines without clinical signs of oesophagogastric disease. The plaque was visualised by plaque revelator and recorded on each tooth. The calculus and condition of gingiva was determined according to the modified instruction of WHO, 1987. Both parameters were determined for each sextant of upper and lower jaw. The results of the OHI on the patients with oesophagogastric passage insufficiency (0.3, SD 0.126) was statistically different (p < 0.01) in comparison with control group (0.51, SD 0.25). Pathological changes of gingiva were more prominent in patient with insufficiency and that difference was statistically significant (p < 0.05). Calculus was more evident in control group but statistically insignificant (p < 0.1). The data show that insufficiency of oesophagogastric passage can cause pathological changes of gingiva while the lower OHI and less prominent calculus could be explained probably by better oral hygiene of patients because of bad taste in mouths. PMID- 9951165 TI - Bruxism and psychobiological model of personality. AB - Bruxism is an abnormal activity of the masticatory system, caused by both psychological and occlusal factors. The aim of the study was to determine the possible correlation between the temperament and character of patients and bruxism. Personality profile of 35 bruxism patients, with no history of psychiatric disorder, was studied by means of Cloninger's seven factor model of temperament and character. For diagnosis of bruxism, muscle activity was analysed and occlusal interferences and facets were registered by clinical functional analysis. Temperament and Character Inventory assesses four dimensions of temperament and three dimensions of character. Results suggest that bruxism patients can have following personality traits: exploratory, impulsive, extravagant and irritable, pessimistic, fearful, shy and fatigable, critical, aloof, detached and independent, lazy, spoiled, underachiever and pragmatist. Combined scores of character dimension indicate immature dimensions of character. Inventory is not standardized for the Croatian population, therefore the result should be taken with caution. PMID- 9951166 TI - Biological markers of alcohol related disorders. AB - The authors in this study lay out a relatively new approach to the diagnostics of alcoholism. Measuring the biological markers of this disease is a useful extension of the standard clinical examination and a promising method for improving prevention. Studies about markers of alcoholism provide a new, exact and quantitative way of diagnosing alcoholism, by means of determining the "state" markers, which include markers of the cerebral process of dependency development and markers of acute and chronic intoxication by alcohol; and by means of determining the "trait" markers, which suggest the disposition for the development of alcohol disease. The authors believe that measuring the biological markers is a promising new approach that should improve the diagnostics and prevention of alcoholism. PMID- 9951167 TI - Tuberculosis and alcoholism in Croatia. AB - Alcoholism and tuberculosis represent very difficult problem in treatment because both illnesses require complex treatment which cannot be adequately obtained on classic wards. Tuberculosis in the last 50 years showed the constant decline of incidence--in Croatia (4,500,000 inhabitants) from approximately 20,000 to approximately 2000 cases per year. This study compares preliminary results of AUDIT (Alcohol Use Disorders Identification Test) in the group of tuberculosis patients with the diagnosis of alcoholism (group 1) and in the group of tuberculosis patients who had not the diagnosis of alcoholism (group 2) and who all were admitted to the Hospital for pulmonary diseases and tuberculosis Klenovnik where is an organised unique ward management for tuberculosis and alcoholic patients functioning for the last 25 years on the basic principles of therapeutic community. Their average AUDIT score was 25.44--very high, and all patients scored above 8, what indicated on harmful and hazardous drinking. Additionally, in the group of patients admitted for hospital treatment of tuberculosis without diagnosis alcoholism there were more than 50% of harmful or hazardous alcohol drinkers who ranged 8 or more on AUDIT score, what could indicate that modern identification of hazardous drinking (for example using AUDIT) should be used in all pulmonary and tuberculosis wards. Patients for whom diagnostic procedure shows that they drink harmfully or hazardously should be treated simultaneously for tuberculosis and alcohol use disorders. Because of hidden alcohol problems the group sociotherapy should be organised for all patients at all wards for treatment of tuberculosis in a common and special alcohologic way. PMID- 9951168 TI - Contribution to the ergonomic investigations in textile industry. AB - Ergonomic hypothesis and functional dependences in the system of the worker, machine and environment are treated, with the purpose to find out optimum relation between humanisation and productivity of the work. The characteristics of the technological processes are investigated, which considerably influence the working suitability and the capability of the workers. The experimental procedures for workers stresses and efforts determination are introduced. PMID- 9951169 TI - Application of ergonomics principles of burdening of the worker in the process of clothes cutting. AB - In the technological procedure of clothes cutting, lifting, transferring and putting of textile bundles on the machine for laying of cutting layers are considered to be the most difficult physical tasks. Upon standing position of the worker, centre of the mass is relatively high and hydrostatic pressure of blood column is increased influencing relatively increased blood circulation at the end of extremities. High incidence of muscle-bone and other health problems occur although this job has been classified as an easy one according to the criteria of energy consumption. These are ever growing cause of degenerative diseases of the vertebral column, absence from the work and early invalidity. Distortion of vertebral column towards right and left as well as forward in cervical and lumbar part of the body have been investigated upon monitoring of the work, as well as rotation of dorsal part of the body on the workers in the technological process of clothes cutting. Corresponding mathematical formulation has been shown for this investigation. Size of the distortion and rotation angles were investigated on four workers who perform various technological clothes cutting operations on two variously formed working places. Based on the monitoring of the workers values of vertebral column during working time were established, and also maximum distortion and rotation angles at the beginning and at the end of carrying out of cutting technological procedure, were established. PMID- 9951170 TI - Occupational tooth-wear in clothing industry workers. AB - A research on tooth-wear was done in a clothing factory, focusing on the teeth of the inter-canine sector in 59 workers who had volunteered for the research. The subjects were in the habit of cutting the thread with their teeth instead of using scissors as was prescribed in the production process. In 53 (89.83%) of the subjects, damages of the incisal portion of the tooth were found, whereas in the remaining 6 (10.17%) there were no such changes. No significant difference could be established in the incidence of tooth-wear between the women workers who cut the thread with their teeth constantly and those who only did that occasionally (p > 0.05). Because of the action of pulling a thread across the incisal edge of the incisor, defects--in the form of solitary, oval or multiple cuts (attributed the values 1, 2 and 3)--had been inflicted on the incisal portion of the teeth. Most frequently those were the defects of the enamel (type 2, 1), but in some cases dentin (type 3), also was affected. A somewhat more severe degree of damage was observed from workers biting the purely polyester-made thread (p < 0.05) than from biting the regular sewing type of thread. Education of the workers seems to be the only useful prevention, since we are dealing with only a bad habit. Therefore, the workers should be warned that the seemingly innocent cutting of thread with their teeth could lead to esthetic, functional and restorative problems. PMID- 9951171 TI - Early post-operative complications in oral implantology. AB - Hematoma, postoperative bleeding, edema, early infection, dehiscence, emphysema, air embolism, loss of primary stability of the implant, acute sinusitis, postoperative cutaneous or mucosal anesthesia and loss of central visual field are early postoperative complications. The incidence of early post-operative complication during the first days of postoperative follow-up was inquired. Eleven patients were implanted by 27 DPI implants. The patients were followed up the first day, the second day and the tenth day after the one-phase surgical technique. Dehiscence in 2 patients, edema in 10 patients, hematoma in 2 patient and postoperative bleedings in 3 patients were established. Three implants were removed because loss of primary stability. It is indicated that by proper preoperative and intraoperative as well as postoperative approach it is possible to influence early postoperative complications. Even though postoperative complications are sometimes unavoidable, choosing the most appropriate surgical technique and keeping oral cavity hygiene are the most important factors in prevention. It is concluded that only the loss of primary stability is incorrigible and successes of implanto-prosthetic rehabilitation can be properly and fully evaluated only after 5 to 10 years of follow up period. PMID- 9951172 TI - Prevalence and intraoral distribution of dentin hypersensitivity among students. AB - The exposed dentin which is the result of the consequence of the enamel loss (by erosion, abrasion, attrition), gingival recession or periodontal therapy, as well as anatomic defects often as its result has dentinal hypersensitivity. The purpose of this work is to examine the frequency of dentinal hypersensitivity in relation to the subjective estimation of the examined persons and objectively, by intraoral examination. Forty persons, students from the School of dentistry of average age of 22.35 years were tested and analysed. Subjective data are achieved by the method of questionnaire while the objective ones by pulling the probe in the area of the tooth neck for the purpose of mechanical testing and by air syringe for the cold stimulus. The results show that the clinical hypersensitivity amounts 52.5% in relation to the subjective data 32.5%. The duration of hypersensitivity amounts in average 18 months and the strongest way of its demonstration is the cold and mechanical stimulus. The half of the examined brush their teeth twice a day out of which 72.5% do that by the half hard nylon brush, and the percentage of teeth with cuneiform defects amounts to 4.45. The often phenomenon of dentin hypersensitivity already among the young underline the need of preventive action and removing the damaging factors which contribute to the start of hypersensitivity of the nude dentin. PMID- 9951173 TI - Psychophysiological parameters and children's behavior during dental treatment. AB - Uncooperative children represent one of the leading problems in clinical pedodontics. The hypothesis of this study was that extraverted children reveal greater pain tolerance, lower stress levels and anxiety in general in comparison to introverted ones. A total of 130 children aged 11 to 15 years were studied, 55 boys and 75 girls. In the research, psychological tests were performed along with the measurements of some physiological parameters and children's own assessment of pain intensity. The results revealed the connection between extraverted personality and children's behavior at the dentist's clinic. Pain tolerance, levels of anxiety and general pattern of behavior were significantly dependent on psychological control mechanisms. PMID- 9951174 TI - [Current state of uterine tamponade with Foley catheter in intractable bleeding]. AB - In obstetrics, the uterine tamponade has been used for the control of acute uterine bleeding. However, the control of the acute hemorrhage from the nonpuerperal uterus is more difficult. Four cases are presented with uterine bleeding during dilation and evacuation without response to medical treatment. They were treated with the use of the Foley catheter for 12 to 24 hrs. There were not complications. The uterine tamponade with Foley catheter is a therapeutic option before the radical surgical treatment. PMID- 9951175 TI - [A clinical case. Diagnosis and laparoscopic treatment of ovarian pregnancy]. AB - Ovarian pregnancy is an uncommon presentation of ectopic pregnancy. It's frequency is 0.3-3.0 of all ectopic gestations. Is reported the case of a 33-year old female patient without previous pathology, was admitted because of lower abdominal pain, bloody vaginal discharge, a right adnexal mass, and positive serum pregnancy test. The preoperative diagnosis was tubal ectopic pregnancy. The following case report illustrates the successful application of operative laparoscopy for to treat primary ovarian pregnancy. PMID- 9951176 TI - [Septate uterus with cervical duplication and vaginal partition: a rare malformation]. AB - It presents three cases of Mullerian anomalies with septate uterus and cervical duplication and longitudinal vaginal septum. There are a few previous cases reported. The cases are discussed and the literature is revised. PMID- 9951177 TI - [Incidence of dysmenorrhea and associated symptoms in women aged 12-24 years]. AB - A Menstrual Symptom Questionnaire was administered to 1,066 women students from Mexico City. The questionnaire included general data and 12 symptoms related to dysmenorrhea. The mean age of the participants was 18 +/- 3.2 years. The mean age of menarche was 12.3 +/- 1.3 years. The prevalence of dysmenorrhea was 52.1% for the group < 15 years of age, 63.8% for women between 15-19 years, and 52.3% for the group of 20-24 years. The frequency of absenteeism as a result of dysmenorrhea in the group < 15 years was 4.3%, 9.3% for the group 15-19 years and 19.8% for the group 20-24 years. Systemic symptoms accompanying dysmenorrhea were clustered for analysis. The most frequent symptoms associated with dysmenorrhea were nervousness, depression, irritability and sleeplessness. Self-medication was prevalent, the most utilized drugs being antispasmodics. PMID- 9951178 TI - [Toxoplasmosis and threatened abortion]. AB - To know the situation of the toxoplasmosis in Comitan Chiapas, we made a serological indirect inmunofluorecent antibody test (IFA) to the population of this city and to fifty women with abortion in evolution. The results show us that around five percent of the population in general have positive title of antitoxoplasma gondii antibiodies, and 18% in the women with abortion evolution case. The statistics concluded that seropositive for this parasitic disease is real higher between cases of abortion than population in general (P < 0.006), as well as it is significantly higher in abortion cases than women of the general population of Comitan Chiapas (P < 0.01). PMID- 9951179 TI - [Janiceps cephalo-thoraco-abdominopagus pregnancy]. AB - Cojoined twins was analyzed type cephalothoracoabdominopagus, is especially rare case of dysgenetic abnormalities, in which the heads, necs, thoraces and abdomen are joined. Twins births joined have been said to occur with a frequency of 1 per 100,000 deliveries, but the incidence of this malformations is one in three million conjoined twins. Conjoined twinning may be associated with a more fundamental failure of embryonic migration or may be associated with a more fundamental failure of ambryonic migration or fusion, 95% of conjoined twins are females. The Janiceps type of cephalothoracoabdominopagus derives its name from Janus, in Roman nythology, the god of doors and gateways, his statue with two faces, facing east and west for the beginning and ending of the day. The anatomic features with the Janiceps type of cephalothoracoabdominopagus are describe, and the mechanisms that may have played a role in the abnormal development of these twins are discussed. The mother was a 22-year-old, with last menstrual period January 12, 1997. She came to the other medical center, with an ultrasound study performed at 27 weeks' gestation, and possible multiple fetal anormalies, a second ultrasound examination, confirmed abnormalities, two hearts, as well as polihidramnios. Past history included normal espontaneous vaginal delivery of healthy term infant, who were alive and well, family history was negative for congenital anormalies, and no prior history of twinning. She denied use of drugs, alcohol, or cigarettes; had no fever, vaginal bleeding, or other problems with the pregnancy. The abdomen was gravid to 48 cm, and contractions were palpable, fetal heart tones were 1400 beats per minute. On the one day of admission the patient underwent delivery of conjoined infants, the Apgar scores were zero at 1 minute and at 5 minutes. The infants were joined front-to-front, with two faces, each a compositive of toth twins, each twin han four extremities, in each face resambled a one nose, with structure incomplete in one face, esophagi were fused. Each twin had its own skeletal system extending from the cervical spine downwards. The congenital malformations for each conjoined twin are listed in the autopsy report, abnormalities included absent ovary and uterus in both twin. COnjoined twins develop from a single zygote, the cause is unknown. We proposed, embryonic tissue divides incompletely, likely to result in twinning anomalies from the 15th to 16th day postovulation, during the late part of period six, about the third week. PMID- 9951180 TI - [Usefulness of the trans-umbilical incision in laparoscopic surgery]. AB - Most surgeons induces pneumoperitoneum with the Verres' needle via an infra or a supraumbilical route; only a reduced group does it true the umbilicus. This paper reports the authors experience using the trans-umbilical route emphasizing its differences and advantages over the conventional umbilical approach. The files of our last 100 laparoscopic cholecystectomies performed in different hospitals were reviewed. Trans-umbilical route was used in 93 cases. Four patients were found to have an umbilical hernia with no content in its sac and it did not compromised the approach. In 7 cases the semi-open technique had to be used because of previous abdominal surgery. There were no major complications during the induction of the pneumoperitoneoum; no hematomas infections or post-operative umbilical hernias either, just a mild pneumopreperitoneum occurred in 5 patients. Trans-umbilical approach for pneumoperitoneum induction is useful, safe, easy to repair, has a low infection rate, and provide better cosmetic results; scar is almost invisible deep in the umbilicus. This approach has several advantages over the ordinary umbilical approaches by been cautious and by using the authors' technique, mini-invasive procedures can be initiated quick and safely. PMID- 9951181 TI - [Myths, prejudices and reality about dental treatment during pregnancy. A medical opinion]. AB - The education and assistance strategies aimed al preserving oral health must play an important role in the overall care of the pregnant woman. It has been demonstrated that there are beliefs and practices in our culture that relegate, odontologic care in this stage, where attitudes and behaviors on the health disease process are influenced by the prevailing medical culture, which includes the physician's opinion. The objective was To obtain the physician's opinion on the odontologic care during pregnancy. A previously validate survey which included 15 questions, was applied to a randomly selected sample of 700 physicians. Of the 650 surveys analyzed, 57% were applied to general practitioners, 24% to gynecologists and obstetrician, and 19% to other medical specialist regularly consulted by women during their prenatal care. There is low referral of pregnant women to the regularly check their patients teeth of gums 53% physicians said that the odontologist did not need to consult them about dental treatment, while 593 thought otherwise, 362 surveyed practitioners point out the convenience of using the lead apron when taking periapical x-ray. These results point out the importance of establishing a good communication channel between the physician and dentist. It is clear that there is a lack of truth in the oral health specialist's ability to provide treatment to pregnant patients, and that the physician ignores many of the odontological procedures and their low risk. PMID- 9951182 TI - [Prolactin and its role in the regulation of ovarian function]. AB - The prolactin is a versatile hormone with important functions in various phenomena such as immunological and reproductive process. Historically, the ovary prolactin association has been viewed almost exclusively in the context of the hyperprolactinemia, although there are evidences that propts toward a direct control on ovarian function. Recently has been identified the synthetic apparatus of human prolactin localized in granulosa cells of ovarian follicle, it suggest an autocrine mechanism of prolactin in the intraovarian control. It is important ot establish the relations between the prolactin secreted by the pituitary and the prolactin-like peptides secreted by immunocompetent, endothelial and ovarian cells in several physiological and physiopathological states. PMID- 9951183 TI - Our expanding South Carolina Medicaid managed care program. PMID- 9951184 TI - Public-private partnerships: working at the local level to increase the quality and number of medical homes for Medicaid children. AB - We have described a process in which one state's public health leaders provided a large degree of flexibility at the community level to improve pediatric health care access for children in need. This "room-to-wiggle" allowed program providers to tailor their programs to the specific needs of their communities while remaining faithful to the statewide goals. Among the most promising outcomes of the coordinated efforts to forge public-private partnerships is the continuation of the relationships that developed in the process and the further collaborations they have spawned. PMID- 9951186 TI - Medicare update. PMID- 9951185 TI - South Carolina physician-naturalists, 1835-1895. PMID- 9951187 TI - Medicaid update. PMID- 9951188 TI - Jim Knight and the moral nature of medicine. PMID- 9951189 TI - Prolonging pregnancy and preventing premature birth: elusive goals for perinatal health care providers. PMID- 9951190 TI - Yes, Virginia, there is a right way to write. PMID- 9951191 TI - International affairs. Irish nursing for the next millennium. PMID- 9951192 TI - Legal and ethical issues. Knowing good and doing good--is there a difference? PMID- 9951193 TI - Education. The baccalaureate revolution. PMID- 9951194 TI - Inquiry, insights, and history. Leadership and a spirit of service. PMID- 9951195 TI - Life on the "Genius" track. PMID- 9951196 TI - Curriculum trends in nurse practitioner programs: current and ideal. AB - The purpose of this study was to ascertain the extent to which nurse practitioner (NP) education programs are addressing curriculum topics related to practice competencies needed for the next century as recommended by the Pew Health Professions Commission and other professional organizations, including the American Association of Colleges of Nursing and the National Organization of Nurse Practitioner Faculties. The study was part of a comprehensive survey of 11 health professions education programs. NP program directors indicated greatest dissatisfaction with curriculum coverage of "use of electronic information systems" and "business management of practice." The three most important curriculum topics identified by respondents were "primary care," "health promotion/disease prevention," and "effective patient-provider relationships/communication," identical to the three topics rated most important by all groups combined. The most significant barriers to change identified by the respondents included "an already crowded curriculum" and "limited availability of clinical learning sites." Findings show that NP program directors perceive that they are doing an effective job addressing most of the 33 curriculum topics, but they also recognize a need to continue to improve their curricula in response to the ever-changing health care environment. Barriers to achieving the desired curricular improvements, however, may be significant. Recommendations for overcoming these barriers to change are offered. PMID- 9951197 TI - Transforming academic nursing: from balance through integration to coherence. AB - Academic institutions continue to be challenged to enhance their productivity in the face of diminishing resources. Escalating demands on full-time faculty must come from a fundamental transformation in the focus and, hence, design of that work. This article presents a model of a mission transformed from the current representation of the tripartite activities involved with teaching, research, and service to a new representation of the inherent holism of that work. This transformation moves the academy's mission to a single, integrative focus on knowledge work. When the essence of the academy's unique mission is expressed as knowledge work, the unity of knowledge development, dissemination, and application can be actualized in the work lives of a community of scholars. A fuller realization of the inherently holistic nature of this knowledge work is seen as a transformation to coherence at the levels of university, unit, and scholar. Coherence within the academic lives of individuals, the collective community of scholars, and the broader organization is the essential feature for the long-term success of the institution and the career of a scholar. PMID- 9951198 TI - Substruction: illustrating the connections from research question to analysis. AB - This article examines the process of theoretical substruction as a heuristic device to assist graduate students and beginning investigators identify the conceptualization and operationalization phases of research proposals. As a thinking process, substruction enables investigators to delineate the foundational elements of studies. Creating the figure during substruction helps researchers increase their knowledge of the theoretical, empirical, or descriptive links between the conceptual and operational components of a study. Consequently, the researcher ascertains the fundamental pattern of the study. A qualitative and a quantitative example of substructed studies are included. PMID- 9951199 TI - An interdisciplinary community-based educational model. AB - The purpose of this article is to describe an innovative partnership among academic, community, and service to better meet the health care needs of underserved populations. The Center for Community Health Education, Research, and Service--a coalition of Boston education institutions, health services providers, and community agencies--was formed with a grant from the W. K. Kellogg Foundation. The initial goal was to establish academic community health centers comparable to the large teaching hospitals that combine service, education, and research as the corner-stone of their mission. With faculty based in the neighborhood health centers, students have learning opportunities to assess, plan care, and treat individuals and families using a community-based primary care model. The nature of the partnership, including the structure and process of implementation, is described. The developmental socialization of advanced practice nursing students in a community based-setting is discussed. Educational and service outcomes are identified. PMID- 9951200 TI - Personnel resource distribution for nursing programs in Carnegie-classified Research I and II and Doctoral I institutions. AB - Increasingly, nursing education programs, like other major institutions in the United States, are being charged to "do more with less." How to acquire sufficient human and material resources is a continuing challenge in an era of economic constraint. Benchmark data on the distribution of personnel resources within nursing programs is nearly nonexistent. To assess the personnel resources of nursing programs of major size and stature within the United States, a Personnel Resource Survey was mailed to the universe of all nursing programs located in Carnegie-designated Doctoral I, Research II, and Research I universities and/or colleges in the United States (n = 96). The return rate was 58 per cent, with a useable survey rate of 51 per cent (n = 49). Comparative numbers and ratios of administrators, faculty, students, and various levels and types of support staff by Carnegie-type institutions are presented. Findings indicate that, overall, nursing programs in Research I universities had 1.5 to 2 times as many personnel resources per student than programs in Doctoral I and Research II institutions. Doctoral I and Research II programs closely resembled each other. The details of the data, as well as its standardization into full time equivalents, are useful to both university and nursing administrators, faculty, and staff in their comparisons and procurement of needed resources. PMID- 9951201 TI - Nursing students respond to a computer assignment. AB - Computer-generated information is becoming increasingly important in nursing. Nursing schools are faced with the need to ensure that students have basic informatics skills and rudimentary computer literacy. This article describes the introduction of an assignment using electronic communication skills within a teaching-learning course in a baccalaureate program. The assignment was designed to introduce the students to several tasks that would be useful to them in their studies as well as in their care of clients. Students learned to send electronic mail, post to a class list, use search engines, access libraries, and critique web pages. They developed increased confidence and skill, advancing from informed user to proficient user status as identified by Ronald & Skiba. The students' appraisal of the assignment in terms of value to their nursing education and their nursing careers indicated that they recognized the value of these skills for their professional nursing lives. Activities were monitored for content and technical glitches. Lessons learned are highlighted, and "Inbox overload" is identified. The authors found that nursing curricula can be designed to meet the challenge of fostering computer literacy. The assignment could be easily adapted for continuing education or other professional education endeavors. PMID- 9951202 TI - Review of anorexia and bulimia. PMID- 9951203 TI - Medication-induced hypomania in Asperger's disorder. PMID- 9951204 TI - Paroxetine in autism. PMID- 9951205 TI - Cyproheptadine and SSRIs. PMID- 9951206 TI - Carbamazepine and methylphenidate in ADHD. PMID- 9951207 TI - OCD symptoms in a young child. PMID- 9951208 TI - Changes in the practice of child and adolescent psychiatry: are our patients better served? PMID- 9951209 TI - Dimensional scales and diagnostic categories: constructing crosswalks for child psychopathology assessments. PMID- 9951210 TI - Adolescent outcomes of childhood disorders: the consequences of severity and impairment. AB - OBJECTIVE: To examine the adolescent consequences of clinical and threshold-level psychiatric disorders, with and without significant functional impairment; to predict serious emotional disturbance (SED: clinical-level diagnosis with impairment); and to examine sex differences in the consequences of emotional and behavioral disorders. METHOD: 300 children aged 7 through 11 years were recruited from urban and suburban offices of a large health maintenance organization (HMO). Child and parent were interviewed at home using the Diagnostic Interview Schedule for Children (DISC), version 1.3. Five to 7 years later, 278 (93%) of the sample were reinterviewed using the DISC-2.1. RESULTS: There was considerable continuity of psychopathology, particularly in children with functional impairment. Behavioral disorders at every level of severity predicted adolescent SED in both sexes. For emotional disorders, girls but not boys with childhood SED had significantly higher levels of adolescent SED. CONCLUSIONS: Childhood disorders falling below the level of severity required to meet criteria for treatment set by many HMOs or insurance companies nevertheless can carry a significantly increased risk for severe pathology years later. Functional impairment played an important role in the adolescent consequences of childhood psychiatric disorder. PMID- 9951211 TI - Impaired but undiagnosed. AB - OBJECTIVE: To investigate the prevalence and outcomes of individuals with psychosocial impairment not meeting DSM-III-R criteria for any of 29 well-defined disorders and to suggest operational definitions for not otherwise specified (NOS) diagnoses and V codes. METHODS: Two-stage general population sampling resulted in 1,015 youths aged 9, 11, and 13 years being interviewed in the first wave of the Great Smoky Mountains Study. They were reinterviewed 1 year later using the Child and Adolescent Psychiatric Assessment. RESULTS: The weighted prevalence of sibling relational problems was found to be 1.4%. That of parent child relational problems was 3.6% and that of relational problems NOS was 0.6%. The overall rate of symptomatic impairment was 9.4%. Across a variety of "caseness measures," those with symptomatic impairment proved to be more disturbed than those without either a diagnosis or impairment, and as disturbed as those with a diagnosis but without impairment. CONCLUSION: Children and adolescents who do not meet DSM-III-R criteria for any well-defined disorder but who have symptoms associated with psychosocial impairment should be regarded as suffering from a psychiatric disorder. It is suggested that researchers adopt this definition for the many NOS diagnoses included in the DSM nosology and implement it in their research diagnostic algorithms. PMID- 9951212 TI - Sherlock Holmes and child psychopathology assessment approaches: the case of the false-positive. AB - OBJECTIVE: To explore the relative value of various methods of assessing childhood psychopathology, the authors compared 4 groups of children: those who met criteria for one or more DSM diagnoses and scored high on parent symptom checklists, those who met psychopathology criteria on either one of these two assessment approaches alone, and those who met no psychopathology assessment criterion. METHOD: Parents of 201 children completed the Child Behavior Checklist (CBCL), after which children and parents were administered the Diagnostic Interview Schedule for Children (version 2.1). Children and parents also completed other survey measures and symptom report inventories. The 4 groups of children were compared against "external validators" to examine the merits of "false-positive" and "false-negative" cases. RESULTS: True-positive cases (those that met DSM criteria and scored high on the CBCL) differed significantly from the true-negative cases on most external validators. "False-positive" and "false negative" cases had intermediate levels of most risk factors and external validators. "False-positive" cases were not normal per se because they scored significantly above the true-negative group on a number of risk factors and external validators. A similar but less marked pattern was noted for "false negatives." CONCLUSIONS: Findings call into question whether cases with high symptom checklist scores despite no formal diagnoses should be considered "false positive." Pending the availability of robust markers for mental illness, researchers and clinicians must resist the tendency to reify diagnostic categories or to engage in arcane debates about the superiority of one assessment approach over another. PMID- 9951213 TI - Accuracy of parent mental health service reporting: results from a reverse record check study. AB - OBJECTIVE: To examine the feasibility of conducting a reverse record-check study to validate parent reporting on child mental health service use and to examine the accuracy of parent reports of child mental health services. METHOD: Information about child service use was abstracted from medical records and subsequently compared with reports provided by caregivers in telephone interviews. A sample of children using outpatient psychiatric services was compared with a sample of children using outpatient orthopaedic services. Rates and correlates of successful caregiver tracking and of service use reporting accuracy were explored. RESULTS: Caregivers of nearly 30% of all index children were contacted and interviewed. Parent reports of lifetime mental health service use were more accurate than reports of lifetime receipt of orthopaedic services. Elapsed time between survey interview and last treatment episode was negatively associated with reporting accuracy. Number of clinic visits was positively associated with reporting accuracy. Preliminary findings suggested that questions about mental health services may be considered sensitive by parents whose children use them. CONCLUSIONS: Reverse record-check studies based on telephone interviews are potentially problematic with a sample drawn from a large, inner city medical center. Findings suggest that memory difficulties may be a more important correlate of reporting accuracy than response editing (social desirability). Potential discomfort with disclosure of mental health service use does not result in service use underreporting. PMID- 9951214 TI - DSM-IV and ICD-10: a comparison of the correlates of ADHD and hyperkinetic disorder. AB - OBJECTIVE: To examine directly the extent to which ICD-10 hyperkinetic disorder and DSM-IV attention-deficit/hyperactivity disorder (ADHD) identify the same children with the same difficulties. METHOD: Participants were children referred for symptoms of overactivity, inattention, and impulsivity, and a normal control group. Diagnostic criteria for ICD-10 hyperkinetic disorder and DSM-IV ADHD were applied retrospectively. Four groups were identified: hyperkinetic disorder and ADHD (n = 21), ADHD only (n = 22), clinic control (n = 15), and normal control (n = 19). The groups were compared on measures reflecting the central characteristics of ADHD, neurodevelopmental functioning, academic and cognitive functioning, and the presence of conduct problems. RESULTS: There is some evidence of increased symptom severity in the combined diagnostic group. Few differences emerged on measures of neurodevelopmental, academic, and cognitive functioning. Rates of conduct disturbance were similar in both ADHD groups. CONCLUSIONS: DSM-IV criteria identify a broader group of children than those identified by ICD-10. However, there is substantial overlap between the groups formed with these different criteria. PMID- 9951215 TI - ADHD boys in young adulthood: psychosocial adjustment. AB - OBJECTIVE: To prospectively examine psychosocial functioning in young adulthood in children with attention-deficit/hyperactivity disorder (ADHD). METHOD: This 10 year prospective study compared psychosocial functioning in 18 young adult men in whom ADHD had been diagnosed in childhood and 18 male controls who had never been psychiatrically ill. Subjects' average age was 21 years at follow-up. Interviews assessed subjects' educational, occupational, residential, and marital status; utilization of mental health services; and psychological status. RESULTS: Young adults with ADHD were significantly more likely than controls to be using mental health services, to report psychological problems, and to have fathered children. In addition, a trend indicated that young men with ADHD were more likely to have dropped out of high school but subsequently attained a graduate equivalency diploma. There was also a trend for young adults with ADHD to report a greater history of trouble with the law; however, the groups did not differ on current legal problems. CONCLUSIONS: Overall, these young adults with ADHD appear to have overcome educational and legal difficulties experienced during high school. However, continued problems in psychological functioning appear to persist into young adulthood. PMID- 9951216 TI - Association between hyperactivity and executive cognitive functioning in childhood and substance use in early adolescence. AB - OBJECTIVE: To determine whether deficient executive cognitive functioning (ECF) in association with high behavioral activity level comprise components of the liability to substance abuse. METHOD: A high-risk (HR) group having fathers with a lifetime DSM-III-R diagnosis of a psychoactive substance use disorder was compared with a low-average-risk (LAR) group whose fathers had neither psychoactive substance use disorder nor another adult Axis I psychiatric disorder. ECF and behavioral activity were measured using neuropsychological tests, activity monitor, diagnostic interview, and informant ratings when the subjects were 10 to 12 years of age. Alcohol, tobacco, and cannabis use were measured at 2-year follow-up. RESULTS: At baseline, the HR group had a significantly higher behavioral activity level and exhibited poorer performance on ECF tests than the LAR group. By early adolescence, HR subjects had a higher lifetime rate of tobacco and cannabis use and earlier age at onset of cannabis use. ECF capacity, but not behavioral activity level, predicted tobacco and cannabis use, total number of drugs ever tried, and severity of drug involvement. ECF accounted for additional variance beyond the effects of conduct problems on these outcomes. CONCLUSION: Whereas behavioral activity and ECF capacity in late childhood distinguishes HR from LAR youth, childhood ECF capacity is the more salient predictor of drug use in early adolescence. PMID- 9951217 TI - Cardiovascular effects of desipramine in children and adults during exercise testing. AB - OBJECTIVE: In light of recent reports of sudden death in children being treated with desipramine (DMI), 3 of which were associated with physical exercise, the authors examined the effects of DMI on exercise in children and adults before and during DMI treatment. METHOD: Before treatment, 22 subjects (9 children, 13 adults) participated in a graded treadmill exercise test. Outcome measures included exercise tolerance, cardiovascular, and electrocardiographic parameters at progressive intensity levels and serum norepinephrine (NE) levels before and after exercise testing. Subjects were then treated with DMI, titrated to an average DMI dosage of 3 mg/kg, and underwent repeated exercise testing. RESULTS: DMI treatment was associated with a significant elevation of circulating NE levels in the pre-exercise assessment. Exercise tolerance was not affected by DMI, and blood pressure and heart rate effects were modest. The cardiovascular impact of DMI treatment was similar in children and adults. One 31-year-old subject exhibited a brief episode of ventricular tachycardia associated with exercise during DMI treatment. CONCLUSIONS: DMI has only minor effects on the cardiovascular response to exercise, and these effects do not appear age-related. However, DMI may increase the risk of exercise-associated arrhythmias in rare individuals. PMID- 9951218 TI - Neuroleptic malignant syndrome in children and adolescents. AB - OBJECTIVE: Neuroleptic malignant syndrome (NMS) is a serious iatrogenic condition. This report reviews the world literature to characterize the syndrome and evaluate factors that promote early detection and effective intervention. METHOD: The review identified 77 NMS cases (49 males, 27 females, 1 gender unknown); ages ranged from 0.9 to 18 years (mean 14.8 +/- 3.96). Univariate and multiple regression analyses were applied to 38 variables to identify early signs of the disorder, to identify correlates of outcome, and to evaluate treatments. RESULTS: The duration of NMS spanned from 1 to 119 days. Nine percent of patients died and 20% resolved with serious sequelae. Patients receiving low-potency neuroleptics had a poorer outcome (p = .01). Fever was related to longer duration of illness (p = .03). Anticholinergics and bromocriptine were effective and without fatalities, but dantrolene was not useful in this sample of children and adolescents. CONCLUSIONS: Early detection and appropriate interventions appear important in moderating the course and outcome of NMS. PMID- 9951219 TI - Functional magnetic resonance imaging of facial affect recognition in children and adolescents. AB - OBJECTIVE: To examine further the role of the amygdala in the recognition of facial expression in adolescents. METHOD: Twelve healthy adolescents were studied using functional magnetic resonance imaging technology during a task of facial affect recognition and a visual control task. RESULTS: All subjects demonstrated a significant increase in signal intensity in the amygdala for the facial expression recognition task. CONCLUSIONS: The data are consistent with previous work in healthy adult subjects implicating the amygdala as essential for the recognition of fearful facial expression. PMID- 9951220 TI - Applicability of personality disorder criteria to hospitalized adolescents: evaluation of internal consistency and criterion overlap. AB - OBJECTIVE: The authors examined the applicability of personality disorder criteria to adolescent inpatients by evaluating internal consistency and criterion overlap. METHOD: Thirty-eight adolescents and 28 adults were assessed with the Personality Disorder Examination. Within-category cohesiveness (internal consistency) of the criteria was evaluated by examining intercriterion correlations as well as coefficient alpha. In addition, between-category criterion overlap was evaluated by examining "intercategory" intercriterion correlations between all pairs of disorders. Separate analyses were conducted for adolescents and adults, and the groups were compared. RESULTS: Internal consistency appeared to be lower in adolescents, as measured by intercriterion correlation and coefficient alpha, with the largest differences being identified for most cluster B disorders. Intercategory analysis indicated that criterion overlap may be greater among adolescents. CONCLUSIONS: Overall, this psychometric analysis suggests that there may be limitations to the DSMs approach to categorizing personality disorders. For both adolescents and adults, modest degrees of within-category cohesiveness (internal consistency) and between category criterion overlap were observed. Comparatively, personality disorder criteria in adolescents tended to have lower internal consistency and less discriminant validity. The data raise questions about the construct validity of these disorders--or the applicability of these criteria--within this age group. PMID- 9951221 TI - Psychological risk factors for borderline pathology in school-age children. AB - OBJECTIVE: To determine whether children with borderline pathology have a specific pattern of psychological risk factors. METHOD: The subjects were 94 school-age children in day treatment, divided into borderline (n = 41) and nonborderline (n = 53) groups using the child version of the Retrospective Diagnostic Interview for Borderlines. All children were assessed using the Child Behavior Checklist, the Schedule for Affective Disorders and Schizophrenia for School-Age Children, and the Psychosocial Questionnaire. Parental pathology was assessed by a computerized version of the Structured Clinical Interview for DSM III-R. RESULTS: Children with borderline pathology had higher rates of physical abuse, sexual abuse, severe neglect, as well as family breakdown and parental criminality. In multivariate analyses, the discriminating factors were sexual abuse and parental criminality. Borderline pathology was highly comorbid with conduct disorder, but most of these results remained significant in reanalyses comparing children with and without conduct disorder. CONCLUSIONS: Borderline pathology in children has a unique pattern of risk factors not accounted for by conduct disorder alone. PMID- 9951223 TI - Definition, purposes, and dimensions of research. PMID- 9951222 TI - The "achievement by proxy" spectrum: recognition and clinical response to pressured and high-achieving children and adolescents. PMID- 9951224 TI - Development of the cerebral cortex: XIV. Stress impairs prefrontal cortical function. PMID- 9951225 TI - [Meta-analysis is a good help for literature review. It makes the analysis of earlier studies more efficient and more objective]. PMID- 9951226 TI - [Monopoly is not the same as non-commercial]. PMID- 9951227 TI - [Different professional groups must show respect for each other]. PMID- 9951228 TI - [Is thrombosis prophylaxis necessary in surgical procedures with short length of stay?]. PMID- 9951229 TI - [What is the value of one year of life saved with nicotine preparations? How did the SBU calculate?]. PMID- 9951230 TI - [Both quality and quantity are required for good internship]. PMID- 9951231 TI - [Intensified insulin treatment is cost-effective]. AB - Both the Diabetes Control and Complications Trial (DCCT) in USA/Canada, and Stockholm Diabetes Intervention Study (SDIS) showed intensified insulin treatment and reduced glycaemia to prevent complications in patients with insulin-dependent (type I) diabetes mellitus. In the DCCT, the intensified treatment was considered cost-effective. In the SDIS, investigation of the direct increase in costs due to the intensified insulin treatment showed the saving in direct costs due to the reduction in photocoagulation requirements, and in the prevalence of renal insufficiency and of amputation, to correspond to 10 years' intensive insulin treatment. Thus, as intensified insulin treatment in type I diabetes reduces direct suffering at a low cost, it may be regarded as 'evidence-based' and mandatory. PMID- 9951232 TI - [Treatment of type 2 diabetes. Early detection of secondary oral treatment failure is important]. AB - As type II diabetes is caused by decreased insulin secretion and increased insulin resistance, treatment must be aimed at the correction of these abnormalities. To this end, oral hypoglycaemic agents (OHAs) are used once adverse lifestyle factors have been suitably modified. New OHAs are being developed, or have already been approved. Subsequent treatment failure, after an initially satisfactory response, occurs in 5-10 per cent of patients on OHAs, and is currently treated with a combination of an OHA for daytime use and NPH insulin (isophane insulin) for use at bedtime. This yields metabolic control at least as good as that obtained with intensive insulin treatment, and at less risk of weight gain. PMID- 9951233 TI - [Accident prevention has been beneficial. A historical reflection and current update]. PMID- 9951234 TI - [Focus on children! A model for international development cooperation]. AB - The plight of children in many low-income countries continues to be reminiscent of conditions in 19th century Sweden. At the threshold of the 21st century, we would urge global cooperation in child health with the aim of realising a broader concept of health and development in low-income countries. This would enable the reduction of mortality to be accelerated and child health to be improved by targeting sick children for specific intervention, combined with preventive and health promotion measures. PMID- 9951235 TI - [New studies on the cardiac effect of estrogens in women. Hormone replacement as secondary prevention is not to be recommended]. PMID- 9951236 TI - [Animal models give quick answers. Problems appear if the scientific results are too early applied to humans]. PMID- 9951238 TI - [Fine art for the price of severe mental suffering?]. PMID- 9951237 TI - [Consequences of scientific misconduct and fraud. Is a "scientific research committee" required?]. PMID- 9951239 TI - [Mentally disabled persons are the most inoffensive ones]. PMID- 9951240 TI - [New discoveries on St John's wort can improve pharmacotherapy in depression]. PMID- 9951241 TI - [The anatomical atlas on CD is not ethically defensible]. PMID- 9951242 TI - [Spin and pour off! Homocysteine is non-perishable when handled correctly!]. PMID- 9951243 TI - [Sildenafil (Viagra) is contraindicated in tapetoretinal degeneration]. PMID- 9951244 TI - [Palliative medicine. A new research field with specific demands]. AB - Palliative care is not merely a question of treating symptoms irrespective of cause, but is ideally based on proper analysis, treatment and evaluation. Education, quality assurance, clinical development and research are needed to improve palliative care. Education and research should be focussed on all four dimensions--the physical, the emotional, the social, and the existential. Research should be designed to address specific issues--for example, how anxiety and mood disturbances in (previously healthy) patients in palliative care differ from anxiety and depression in a psychiatric setting, in patients with a history of psychiatric problems. Efforts need to be made to link significant clinical problems and basic science. Not until we understand the underlying mechanisms (e.g., the involvement of cytokines in mediating cachexia), will it be possible to develop new treatment strategies for problematic symptoms. PMID- 9951245 TI - [About being a physician when the patient will die]. PMID- 9951246 TI - [Poor leadership behind poor pain relief. Medical audit of cancer-related pain treatment]. AB - A clinical audit of the treatment of cancer-related pain, ordered by Stockholm County Council and the Karolinska Institute, was performed at two Stockholm hospitals. Of 153 consecutive cancer patients interviewed while attending the preoperative out-patient clinic of the Dept. of Anaesthesiology at Karolinska Hospital, 93 (61%) reported pain varying in intensity from 2.4 to 6.6 on a 10 point visual analogue scale. The pain was cancer-related in 20 patients, treatment-related in 28 patients, and associated with disease in 40 patients (e.g., post-herpetic neuralgia, urethritis, decubital ulcer or constipation). Nine patients had undetected neuropathic pain components, and 18 patients reported both significant pain intensity and dissatisfaction with the treatment. The auditors found these patients to have persistent pain problems despite the availability of time and opportunity to resolve them. The audit included interviews with staff at three hospital departments, who filled in questionnaires, and scrutiny of the medical records of about 120 cancer patients, 5-10 records from each department being selected to illustrate the management of pain problems. Findings from the staff questionnaires and interviews were compared with the picture of pain management elicited from the patients' records. The hospital departments were all found to be characterised by similar problems: lack of pain analysis or diagnosis, failure to detect neuropathic pain components, and underdosing of opioid analgesics irrespective of pain intensity. The auditors' conclusions included a need of pain education, particularly for doctors as fewer doctors than nurses had attended pain courses. PMID- 9951247 TI - [The diabetic foot. Optimal prevention and treatment can halve the risk of amputation]. AB - Almost half of all lower leg amputations are performed in patients with diabetes. In over 70 per cent of these cases, amputation is precipitated by progression of foot ulceration to deep gangrenous infection. Most foot ulcers are preceded by trauma, usually due to ill-fitting shoes, and are precipitated by sensory motor neuropathy with varying degrees of peripheral vascular disease. The Swedish Medical Research Council and the Swedish Institute for Health Services Development arranged a conference on diabetic foot problems in April 1998, the purpose of which was to arrive at a consensus regarding the prevention and management of diabetic foot. It was concluded that a satisfactory multidisciplinary approach should include regular control of feet and footwear, preventive foot care (education, footwear, chiropody), continuous follow-up of high-risk feet, and early recognition of revascularisation. Continuous registration of amputation, irrespective of type, cause and site, might substantially reduce the amputation rate among diabetics. Were such an approach to reduce the incidence of diabetes-related amputation by 50 per cent, annual costs for the management of diabetic foot in Sweden would be reduce by SEK 400 million (the value of improved quality of life not taken into consideration). PMID- 9951248 TI - [Infections and treatment of chronic leg ulcers: the use of antibiotics is too excessive, restrictive prescription is recommended]. AB - Chronic venous leg ulcers are contaminated or colonised with bacteria that seldom affects ulcer healing. Signs of clinical infection appear in only a minority of chronic ulcers. In spite of this, data show a high consumption of antibiotics in this group of patients. Treatment with antibiotics is indicated only when clinical signs of infection or obvious risk factors are present or when Streptococcus pyogenes is isolated from the ulcer. In these cases an oral antistaphylococcal agent (semisynthetic penicillinase-resistant penicillin or first generation oral cephalosporin) is recommended as the first choice. Enterococci, anaerobic bacteria and gram-negative bacteria including pseudomonas spp. often colonise chronic ulcers, but do not usually cause antibiotic requiring infection. PMID- 9951249 TI - [Ultrasonic measurement of residual urine is considerate and reliable]. AB - The measurement of residual urine is often an invaluable aid in the examination of patients with prostate enlargement. As a result of the increasing scope of pharmacological treatment options in cases of such urinary problems, more such investigations are now being performed in primary care. Traditionally, residual urine has been measured by catheterisation of the urethra, which is associated with a risk of infection and other complications. As experience of ultrasound measurement of residual urine in 30 patients at a primary health centre suggests it to be a rapid, easily tolerated method unaccompanied by complications, it would seem to be an appropriate procedure even for use in the elderly with any of a variety of chronic diseases. It was also found easy for various categories of staff to learn. PMID- 9951250 TI - [Inflammatory bowel disease in children and adolescents. When can the diagnosis be excluded without a referral to a pediatric gastroenterologist?]. PMID- 9951251 TI - [Immune response and inflammation in Crohn disease. More detailed diagnostics and more specific drugs are soon to be available]. AB - The chronic inflammation in Crohn's disease may be caused by aggressive response to bacterial antigens normal to the gut. Genetic and environmental factors modify the inflammatory response evoked by damage to the mucosal gut barrier. Genetic factors may also determine the subsequent course of chronic inflammation. Further elucidation of the pathogenesis might improve our understanding of the heterogenous nature of Crohn's disease, thus enabling the disease to be subtyped and individualised therapy directed primarily at down-regulation of helper T-cell 1 response to be developed. PMID- 9951252 TI - [Current knowledge on muscle training: endurance and strength yield complementary effects]. AB - Both endurance and strength training are generally agreed to be necessary components of a balanced fitness programme. These two types of training are complementary; strength training improves neuromuscular function, prevents injuries, and is a prerequisite for effective endurance training. Whereas endurance training results in high energy expenditure during exercise, strength training, being associated with increased muscle mass, may result in increased energy expenditure at rest. In conjunction with endurance training, the most striking finding in skeletal muscle is its remarkable adaptability. Indeed, it is usually possible for the muscles to acquire the characteristics necessary to meet prevailing functional demands. This is true even if the demand is continuous contractile activity, 24 hours a day, week after week. The physiological effects of strength training are the result of hypertrophy of individual motor units, mostly comprising type II (fast-twitch) fibres, but are also secondary to neural changes affecting the recruitment and frequency modulation of motor units and co ordination. PMID- 9951253 TI - [Return of the goddesses of childbirth--"back to nature with a little assistance"]. PMID- 9951254 TI - [Time orientation is upset in psychiatric disorders]. PMID- 9951255 TI - [Nature and culture meet in emotional communication]. AB - According to the modern affect theory, the human being is equipped from birth with a number of affect programmes which can be activated both by internal and external signals and by the memory. According to theory, facial expressions constitute an important component of the affect programme. Research findings suggest the human being to be biologically programmed both to send and receive communications via facial expressions. Emotional communication seems to occur at an unconscious level, and to precede conscious information processing. There is scientific evidence that the emotional components of information processing are faster and occur in phylogenetically older brain structures. The right hemisphere appears to be more closely related than the left hemisphere to the autonomic nervous system, and thus more intimately linked with the physiological and automatic components of the emotions. Modern psychodynamic theory, in which emotion and unconscious processes are seen as human driving forces, derives scientific support from emotion research based both upon experimental psychology and neuroscience. PMID- 9951256 TI - ["Murphy's button" became salvation for the nurse's assitant miss Johanna]. PMID- 9951257 TI - Medicaid reimbursement and timeliness of payment. PMID- 9951258 TI - Making Medicaid viable for the 21st century. PMID- 9951259 TI - HMO insolvencies: physicians left holding the bag. PMID- 9951261 TI - Year 2000 computer compliance. How will this affect you, doctor? PMID- 9951260 TI - Charles Gehrke, MD. Helping healers heal themselves. PMID- 9951262 TI - The business of medicine: physicians head back to school. PMID- 9951263 TI - Physicians bring GI diagnosis, procedures to rural Mexico. Doctors Veldman and Wiedemer on a medical mission. PMID- 9951265 TI - Could the sky be falling? PMID- 9951264 TI - Triggers for advance directives. Part Two. PMID- 9951266 TI - [Accidental esophageal intubation]. PMID- 9951267 TI - [Presence of epithelial cells in the medullary canal after spinal anesthesia]. AB - BACKGROUND AND AIM: Several authors have focused on a causal link between the onset of neurological complications after lumbar injections and the fact that epithelial cells may be drawn into the vertebral canal during these procedures. Complications may arise both early (cephalea, septic and aseptic meningitis) and late (epidermoid tumours). The authors aimed to evaluate whether skin fragments which are carried down by the needle during subarachnoid anesthesia may even be present in the epidural or subarachnoid space three days later and may therefore justify the onset of the above neurological syndromes. METHODS: Five adult cats under narcosis underwent subarachnoid anesthesia using disposable 22G Quincke type needles. Between 0.7 and 1 ml isobaric bupivacaine at 0.50% was injected. The presence of the motor block of the lower limbs was ascertained once the effects of general anesthesia wore off. On the third day, again under general anesthesia, cardio-respiratory arrest was provoked by intravenous injection. Samples of meninges were collected in the injection area. After fixation in a phosphate glutaraldehyde buffer, dehydration in acetone, dehydration by critical point and gold metalisation, the samples were examined using SEM. RESULTS: No epidermal cells were found on the surface of the meninges. On the other hand, a squamous epithelial cell was observed which drained inside a sectioned epidural vessel towards the systemic circulation. CONCLUSIONS: This study confirms the possibility that, after subarachnoid anesthesia using 22G Quincke needles, skin fragments may enter the spinal canal. The permanence or otherwise of the epithelial fragments on the third day depends on the size of the fragment drawn down and the efficacy of the drainage system which removes isolated epithelial cells. This phenomenon may justify the self-limiting character of cephalea and meningisms which, even if not treated, regress in a few days, as well as the scarce development of epidermoid tumours. PMID- 9951268 TI - [Premedication with intranasal midazolam in children of various ages]. AB - BACKGROUND AND AIM: To evaluate the efficacy of premedication with midazolam (mdz) administered using a nasal route compared to diazepam (dz) administered by mouth in children of different ages. EXPERIMENTAL DESIGN: A comparative type study was performed in randomly selected pediatric patients undergoing surgery. The study lasted 3 months. SETTING: Recovery room and operating theatre for Pediatric Surgery and ENT. PATIENTS: A total of 248 patients were studied, divided into 3 age groups: group A were aged under 2 years; group B were pre school age and group C were school-age. OPERATIONS: Two subgroups were formed based on the premedication used: group M = 0.2 mg/kg of mdz using a nasal route on arrival in the operating unit; group D = 0.2 mg/kg of dz per os 45' before induction. PARAMETERS STUDIED: In addition to acceptance of treatment, which was deemed to be good, poor or refused, the authors evaluated the level of sedation (score from 5 to 1: awake-asleep), anxiety on entering SO (score from 1 to 4: none-excessive) and the level of collaboration during the induction of general anesthesia (score 1-4: excellent-nil). RESULTS: The nasal route was well accepted by 59% of patients in group A, 62% of group B and 97% of group C. Statistical analysis using Kruskall Wallis test showed significant differences in groups A and B between the two subgroups M and D for all the parameters studied, whereas there were no significant differences in group C. CONCLUSIONS: Premedication with mdz using a nasal route was safe and efficacious, above all in early and later infancy. PMID- 9951269 TI - [Ciaglia's percutaneous dilatative tracheostomy in intensive care. Perioperative complications and long-term results]. AB - BACKGROUND AND AIM: The introduction of percutaneous tracheostomic techniques using dilatation (PDT) has led to the gradual disuse of conventional methods of surgery. The aim of this study was to evaluate ventilatory function in critical patients during the execution of PDT using Ciaglia's method as well as, in the postoperative phase, the long-term results, namely endotracheal lesions and cosmetic deformities of the stoma. EXPERIMENTAL DESIGN: A prospective study was carried out on a consecutive series of adult patients. SETTING: The intensive care ward of a 600-bed teaching hospital. PATIENTS: A group of 50 critical patients undergoing PDT from 1993 to 1996. Valuations of ventilatory function: expiratory volume (EV), PaO2 and PaCO2, were calculated in 40 patients undergoing PDT. Endoscopic controls of the trachea were performed in 21 surviving patients 60 days after the removal of the tracheostomic tube and a cosmetic evaluation of the tube insertion site was also made in the same patients. RESULTS: During PDT a mean reduction of EV was observed of 1.41/min and PaO2 values also diminished 15% accompanied by a 14.2% increase in PaCO2. The endoscopic control performed after 60 days in 21 out of 50 patients revealed a subglottal stenosis in 1 patient, the presence of nonstenosing cicatricial granuloma in 2 patients, edema in 2 patients and dysepithelisation of the tracheal mucosa in a further 2 patients. The remaining 66% showed flattening of the mucosa and complete restitutium ad integrum. No usurpations and cicatricial tractions of the tube insertion site were observed. CONCLUSIONS: This prospective study of intraoperative ventilatory function and the final outcome of PDT according to Ciaglia confirms that this is a reliable technique for the ventilatory management of critical patients with a low percentage of long-term complications. PMID- 9951270 TI - [Factors determining the successful weaning of patients with "difficult weaning"]. AB - OBJECTIVE: Weaning from mechanical ventilation is often possible in the most of patients, even if sometimes it is very difficult. For example, 25-53% of COPD patients cannot be weaned. The different modalities used do not justify this. The aim of the study was the evaluation of a further weaning trial in tracheotomized patients who underwent mechanical ventilation for at least 15 days in several ICU and in whom several attempts of weaning failed. DESIGN: A retrospective study (January 1993-February 1995). SETTING: Intermediate Intensive Respiratory Care Unit of Centro Medico Di Montescano. PATIENTS: Thirty-nine patients (29 male; 26 COPD, 3 post-surgery respiratory failure, 5 restrictive diseases, 4 with cardiovascular failure and 1 neurological disease) who had been tracheotomized and undergoing mechanical ventilation from at least 15 days. An initial evaluation in which respiratory mechanics and echocardiography were performed was made and then they underwent further weaning trials based on progressive decrease of the level of pressure support and periodic disconnection from MV and on medical therapy and strong physiokinesitherapy. RESULTS: Twenty-six out of 39 patients (66%) could reach definitive weaning (COPD 65%, post-surgery respiratory failure 66%, restrictive 60%, cardiovascular failure 100%, neurological disease 0%) after 17 days of average time of ventilation (range from 4 to 90). Among the important factors in determining a difficult or impossible weaning there are: a) previous wrong ventilation settings 8/26; b) cardiovascular problems 7/26; c) alterations in respiratory mechanics 2/26; d) previous excessive sedation 2/26; e) uncorrect timing of disconnection 2/26; f) poor physiokinesitherapy 2/26; g) unknown causes 3/26. Also the ICU from which the patients has been transferred plays an important role. CONCLUSIONS: The conclusion is drawn weaning from mechanical ventilation can be reached also in a part of those patients who are thought not weanable with a further, prolonged and expensive weaning trial. PMID- 9951271 TI - [Anesthesiologic incidents from esophageal intubation. Presentation of three cases and medico-legal evaluation]. AB - Undiagnosed esophageal intubation is still prominently in anesthesia-related morbidity and mortality. Three cases of undiagnosed esophageal intubation taken into consideration for possible anesthesiologic malpractice are presented. A review of the international anesthetic-related morbidity and mortality statistics indicates that this misadventure remains a problem even among anesthesia personnel, a medical population specifically trained in such a procedure. It is not only the frequency of this misadventure but the potential catastrophic consequences for the patient that underline the importance of being able to recognise and correct an esophageal intubation. The reliability of commonly prescribed methods of assessing tracheal tube position is reviewed and the conclusion is drawn that continuous end-tidal carbon dioxide measurement during anesthesia is perhaps the most reliable means under all circumstances for determining proper tube position and should be employed routinely whenever possible. PMID- 9951273 TI - [Anesthesia with propofol and atracurium in a case of porphyria cutanea tarda]. AB - The conduction of anaesthesia in a patient with a diagnosis of porphyria cutanea tarda is described. The aim of this paper is to provide further evidence for safety of TIVA (Total Intra Venous Anaesthesia) paying particular attention to propofol and atracurium (there are not sufficient data about it in the literature) in patients with porphyria cutanea tarda and high levels of uroporphyrin. The study of the anaesthetic management of a patient suffering from Porphyria Cutanea Tarda (PCT), the most common form of porphyria, can offer useful indications. Due to the fact that PCT is less severe than the acute forms, there is less risk for the patient under anaesthesia. In this particular case preoperative, intraoperative and postoperative urinary porphyrin are compared and furthermore, the liver function and the eventual development of skin lesions are monitored. A not significant increase of urinary porphyrin levels after surgery, no skin lesions and no modifications of liver function have been observed. TIVA proved to be safe in this case of PCT. PMID- 9951272 TI - [Therapeutic objectives and strategies in NBIA 1 (Hallovorden-Spatz syndrome)]. AB - A 10 years old male patient, DG, was admitted in the ICU because of continuous uncontrolled movements due to a neurologycal degenerative disease (Hallervorden Spatz syndrome) able to determine reduction of spontaneous breathing efficacy. At admission he presented acute ventilatory failure, because of a Staphylococcus aureus broncopneumonia, so he had a tracheal tube and mechanical ventilation (pressure support). During hospitalization (4 months in ICU and 2 months in Pediatric Department) DG received tracheotomy and percutaneous gastrostomy, to obtain adequate spontaneous ventilation and artificial enteral nutrition; a satisfactory pharmacological control of choreo-athetosic movements, with not great interference with original sleep-awake cycle, was obtained. Actually DG is living in his family (9 months follow-up); he has tracheotomy and percutaneous gastrostomy; he can relate with the environment; in a few months, he'll go to school again. He need 30 daily administrations of 8 different drugs; family, supported by an integrated multidisciplinary equipe, takes care of him. The role of Intensivist is essential not only in the management of acute phases in chronic diseases, but also in the longterm management of a homely care. PMID- 9951274 TI - Employee/patient confidences. PMID- 9951275 TI - Alan N. Queen is Bernard P. Tillis award winner. Why I became a dentist. PMID- 9951276 TI - Complaint resolution process delivers. PMID- 9951277 TI - Rhinitis mimicking odontalgia: a case report. PMID- 9951278 TI - Science, technology and health literacy for the 21st century. A future for dentistry. Percy T. Phillips Memorial Lecture. PMID- 9951279 TI - Orthognathic surgery: the state of the art. PMID- 9951280 TI - Prostate cancer in African-American men. PMID- 9951281 TI - Caring for patients with sickle cell disease in North Carolina. PMID- 9951282 TI - Underrepresentation of African-American male medical students. Nature or lack of nurture? PMID- 9951283 TI - Saving Sergeant Buske. An account of remarkable valor and amazing survival from the records of the 65th General Hospital, a Duke University Army Reserve Unit of World War II. PMID- 9951284 TI - Rural Eastern Carolina Health (REACH). A model community health improvement program. PMID- 9951285 TI - A survey of beliefs about managed care. PMID- 9951286 TI - Thoughtful death in 1999. PMID- 9951287 TI - Protecting the fetus from in-utero cocaine exposure. PMID- 9951288 TI - The problem of urinary incontinence in the elderly. PMID- 9951289 TI - Will we be able to repair osteoarthritic joints? New drugs and surgical techniques for cartilage problems. PMID- 9951290 TI - The pus is moving. A case of cutaneous myiasis. PMID- 9951291 TI - [Interhemispheric asymmetry in the anterior and posterior sections of in the normal human brain and in unilateral cortical damage]. AB - The study of interhemispheric bioelectrical asymmetry (IBA) of the brain as a result of pair activity of the hemispheres has shown that in normal subjects IBA was greater in the frontal lobes than in the occipital ones. In patients with injured right hemisphere the asymmetry increased in the occipital lobes. In patients with injured left hemisphere the asymmetry diminished in the frontal lobes. PMID- 9951293 TI - [The action of sex hormones on conditioned reflex and behavioral reactions]. AB - The effects of lack of gonadal hormones on the learning ability, retention of memory traces and behavior under conditions of hormonal unbalance produced by extirpation of the endocrine glands in male and female rats were compared. The behavior of the animals was evaluated in active and passive avoidance, and in open field tests. There were differences between male and female rats in formation of active and passive avoidance reactions. Results of the experiments demonstrate that castration of the male rats resulted in impairment of long-term memory and modified behavior; castration of female rats considerably impaired formation and retention of active and passive avoidance reactions but had no effect on behavior of female rats. PMID- 9951292 TI - [The dynamics of aminotransferase activity in the blood plasma as a reflection of the characteristics of the pathological process in patients with craniocerebral trauma]. AB - The activity of alanin-aminotransferase (ALT) and aspartate-aminotransferase (AST) was measured in blood plasma of 103 patients with brain trauma. Sex-related differences were found. One day after the trauma ALT and AST activity rose significantly both in men and women with brain concussion, in males with mild and moderate brain contusion. In severe brain contusion the enzymes activity did not change. Eight days after the trauma AST activity significantly lowered in patients with brain concussion. No changes in aminotransferases activity one day after severe brain contusion evidence for biochemical maladaptation. PMID- 9951294 TI - [The similarity and differences in the circadian fluctuations in the central nervous system reaction of animals to acute gamma radiation and alcohol exposures]. AB - 24-h fluctuations in the response of CNS (occurrence of the complex of neurological disorders) were studied in white rat males which were exposed to gamma radiation (Co-50, 62.5 Gy, craniocaudally) or injected alcohol (2.25 g/kg, 15% solution, i.p.). After alcohol administration, the above fluctuations were at first almost similar to those in response to the radiation. Later, the curve of the CNS sensitivity to alcohol was leveling, rhythm phases shifted without the rhythm inversion. Neurological symptoms induced by alcohol and radiation were very much alike suggesting the existence of common mechanisms of nonspecific regulation evident early after exposure to these two factors. PMID- 9951295 TI - [The immunomodulating action of intermittent fasting under temperature, toxic and food loads]. AB - Immune response to intermittent fasting was studied in rats. The immunomodulating effect was registered. To a certain degree, this may be due to fasting-induced reduction in blood levels of antiproteolytic proteins and lipid peroxidation products which have immunosuppressive activity. PMID- 9951296 TI - [Reducing diet therapy in the correction of the immune disorders in patients with primary osteoarthrosis]. AB - Effects of 14-21-day courses of reducing diet on function of T- and B-system immunity were studied in 35 patients with primary osteoarthrosis, while effects of food deprivation on nonspecific effector system of immune defense and local immune reactions were studied in experiment on R. Altman arthrosis model. It was proved that due to the above fasting the articular syndrome by clinical and laboratory criteria was much relieved. This positive effect is explained by modulating action of diet therapy on T- and B-immunity in combination with stimulation of activity of nonspecific effector system of immune defense. The dependence of the above changes on the treatment period are determined. PMID- 9951297 TI - [The effect of hyperbaric oxygenation on the urea content of the saliva in acute and chronic soft-tissue inflammation in the maxillofacial area]. AB - Urea levels were measured in the saliva of 30 patients with acute and chronic maxillofacial inflammation treated with multiple modalities including hyperbaric oxygenation (HBO). Urea concentrations were evaluated before, in the course of and after HBO session. A total of four 40-min sessions were made (1 session a day, 1.5 atm). Elevated concentrations of urea after HBO are thought adaptive, serving for elimination of ammonia overproduction in hyperoxia. Urea measurements in the saliva can be used for prediction of oxygen intoxication in the HBO exposed patients. PMID- 9951299 TI - [Antioxidant enzyme activity in the erythrocytes of rats with alloxan diabetes]. AB - The authors studied changes in chemiluminescence and activity of three antioxidant enzymes in peripheral blood red cells in experimental diabetes mellitus induced in rats by alloxan injection. Intensification of red cell chemiluminescence reflected enhanced lipid peroxidation. High activity of catalase and superoxide dismutase activity was compensatory. A two-fold fall in glutathione reductase activity from the 7th day after alloxan injection demonstrates a decline in antioxidant defense in diabetes mellitus. PMID- 9951298 TI - [Microwave resonance therapy in primary osteoarthrosis: the pathogenetic validation of its clinical use]. AB - Mechanism of action and clinical efficacy of microwave resonance therapy (MRT) was studied in 114 patients with primary osteoarthrosis. It was found that clinical benefit of MRT in primary osteoarthrosis is due to combined positive effect on nonspecific immune reactivity, endogenic intoxication, lipid peroxidation, activity of antioxidant defense system, local immune reactions. PMID- 9951300 TI - [Changes in the fractional collagen composition of the kidneys in rats under immobilization stress and alloxan diabetes]. AB - Content of free hydroxyproline, total collagen and neutral salt-soluble, citrate soluble, nonsoluble fractions of collagen and also collagenolytic activity on combined immobilization stress days 3, 10, 15 and 30 in alloxan diabetes were studied in homogenates of the cortical zone of rats' kidneys. Changes in the fractional collagen composition were found phasic. The additional stress load on its days 1-10 attenuates but in the following days aggravates the catabolic action of alloxan diabetes on collagen metabolism in the kidneys. PMID- 9951301 TI - [The healing characteristics of skin wounds in different types of alcohol and surrogate intoxication]. AB - White rat experiments were made to study healing of cutaneous wounds in acute and chronic alcohol-substitute intoxications. Physico-morphological, bacterioscopic and cytochemical examinations showed that oral introduction of ethanol, methanol and their mixture inhibited healing of the wounds due to suppuration. PMID- 9951302 TI - [Lipid peroxidation of the bile in patients with calculous and acalculous cholecystitis]. AB - With a new technique for the assessment of lipid peroxidation products in chloroform bile extracts it was possible to register an increase in the ratio malonic dialdehyde/phospholipids in patients with both calculous and acalculous cholecystitis. Bile of all patients with acute cholecystitis was characterized by a decrease in concentration of all the components, but use of relative parameters (malonic dialdehyde/phospholipids, index of bilirubin fractions and cholesterol/lecithin index) allows to verify the stage of the inflammation. The changes were unidirectional in B-bile and C-bile portions in all the patients with acalculous cholecystitis. PMID- 9951303 TI - [The protective action of alpha-tocopherol on kidney function and lipid peroxidation in acute hemic hypoxia]. AB - As shown in experiments on 54 noninbred white male rats, activation of lipid peroxidation in renal cortical substance contributes to impairment of renal function in acute hemic hypoxia. Administration of alpha-tocopherol promoted stimulation of renal protection: reduced the degree of proteinuria, sodium excretion, enhanced proximal reabsorption of osmotically active substances and sodium, glomerular filtration. This was accompanied with increased activity of superoxide dismutase and lowering of malonic dialdehyde concentration in renal cortical substance. PMID- 9951304 TI - [The thiamine index as an integral indicator of the body allowance of vitamin B1]. AB - One of the most wide-spread methods of evaluation of thiamine content in the body is determination of the activity of the thiamine pyrophosphate-dependent enzyme- transketolase--and so-called TPP-effect (the quantitative measure of unsaturation of transketolase with coenzyme). Absence of distinct correlation between the parameters in a number of cases calls for a search for the integral coefficient less dependent on the original dynamics of the given markers. Thus, we propose to use the thiamine index calculated by means of division of transketolase activity index expressed in absolute units by TPP-effect index expressed in relative units. The examples of thiamine index calculation and peculiarities of its interpretation with consideration of dynamic state of chronic alcoholics in abstinence and of patients with acute alcohol psychoses are shown. PMID- 9951305 TI - [The pathology of hemostasis]. PMID- 9951306 TI - [Pedophilic behaviors: the psychopathological aspects]. PMID- 9951307 TI - [The use of HIV-1 protease inhibitors. Their effects on AIDS-correlated outpatient and hospitalization activities. A catchment area study]. AB - OBJECTIVE: To evaluate the effects of the use of protease inhibitors (IP) on the out-patient department's activities and hospitalizations of HIV-1 infected subjects. METHODS: From the December 1996 IP was available in our hospital, so the years 1996 and 1997 were studied. RESULTS: In the year 1997, 336 patients were visited with an increase of the 41% compared with the year 1996. In the 1997 the 45.2% of hospitalizations were related to AIDS, while in the year 1996 the 65.4% of them were related to AIDS. CONCLUSIONS: The use of IP had increased the activities of the out-patient department and certainly had a role in reducing the hospitalizations related to AIDS. PMID- 9951308 TI - [Bronchoalveolar lavage in lower respiratory tract infections in patients with bronchopulmonary carcinoma. Our experience]. AB - In order to evaluate the usefulness of the endoscopic procedures with BAL, we conducted a study on 92 patients with diagnosis of lung cancer, underwent to chemotherapy, identifying pathogenic species involved and the antibiotic sensibility and antibiotic resistance. Moreover, to evaluate possible modifications of alveolar cell population in neutropenic patients, we studied the specimens from BALs performed via fibreoptic bronchoscopy. METHODS: The cellular pattern of BALs in terms of concentration of total cells, concentrations of alveolar macrophages (AMs), of polymorphonucleates (PMNs) and lymphocytes (Ls) were compared in neutropenic and non-neutropenic patients. RESULTS: In the statistical analysis of our study we found a correlation, statistically significant, between patients with neutropenic episodes on the previous chemotherapy courses and incidence of LTRI. The mean concentrations x 100,000/ml of BAL fluid of total alveolar cells, AMs, PMNs and Ls were significantly lower, after chemotherapy, in group of neutropenic patients than in non neutropenic patients, respectively. CONCLUSIONS: In this study we found that during neutropenia the alveolar cell population was quantitatively deficient, confirming the hypothesis, proposed by other authors, of "lung aplasia" as a consequence or a concomitant event of chemotherapy-induced marrow toxicity. PMID- 9951309 TI - [The efficacy of cetirizine in the treatment of mild allergic asthma due to grasses]. AB - We have evaluated the efficacy of cetirizine in 24 patients (18 males and 6 females, mean age 25.4 years) suffering from mild or moderate allergic asthma due to grass pollen. Cetirizine was given once a day at the dosage of 10 mg for four weeks. On a daily card patients had to record the number of asthmatic attacks, the usage of bronchodilatators and the values of peak expiratory flow measured in l/min in the morning and at the evening. The improvement of the parameters considered was statistically significant, and no side effects have been observed. Cetirizine is therefore an effective and safe drug in the treatment of mild and moderate asthma induced by grass pollen. PMID- 9951310 TI - [Systemic Salmonella arizonae infections in patients with a deficiency of cell mediated immunity. A report of 2 cases and a review of the literature]. AB - Systemic infections induced by Salmonella arizonae have been described in patients with underlying cell-mediated immunodeficiencies, usually resident in southern countries of U.S. and in Mexico. This peculiar geographic distribution is probably due to the ingestion of meat or drugs from rattlesnakes, that Salmonella arizonae colonize in the intestinal tract and that live in the above areas. In this article we describe two cases of systemic Salmonella arizonae infections, that represent, to our knowledge, the first report in European literature. PMID- 9951311 TI - [The treatment of laryngeal cancer. Surgical treatment]. PMID- 9951312 TI - [The treatment of laryngeal cancer. Radiation treatment]. PMID- 9951313 TI - [The treatment of laryngeal cancer. Chemotherapeutic treatment]. PMID- 9951314 TI - [The treatment of laryngeal cancer. The concluding considerations]. PMID- 9951315 TI - [Metabolic disorders due to HIV-1 protease inhibitors]. PMID- 9951316 TI - [Antileukotrienes in the therapy of bronchial asthma]. PMID- 9951318 TI - [The natural history of asthma]. AB - Asthma is a chronic inflammatory disease of airways with a multifactorial pathogenesis. Both genetic and environmental factors contribute to the development of the disease which can vary in the same patient through time. Due to its complexity, natural history of asthma is poorly well-known. Generally, in the history of asthma three periods of life are taken into consideration: early childhood, adolescence and adult life. It has been demonstrated that less than one third of children who are affected by wheezing in early childhood develop a true asthma afterwards. Usually in these subjects who are male and atopic, viruses and subsequently allergens represent the most important factors responsible for the development of asthma. During adolescence airborne allergens represent the main cause of the disease: mites in infancy and pollens in late childhood. The incidence of asthma during adolescence is growing according to recent studies, and even if the symptomatology of asthma improves through time, about two thirds of patients remain asthmatic in their adult life. As regards adults etiology, it is less known, women are more frequently affected than men and the prognosis is generally poorer. Several factors negatively influence the course of asthma such as age, smoking, the severity of the disease during infancy, the persistence of functional obstructive alterations and the increased aspecific bronchial reactivity. Adequate therapy is crucially important to cope with these factors and can change the course of the disease. PMID- 9951317 TI - [AIDS and opportunistic visceral mycoses. A diagnostic and therapeutic update]. AB - Candidiasis, cryptococcosis, aspergillosis, histoplasmosis, and coccidioidomycosis are the most commonly recognized visceral mycoses complicating the course of HIV infection and AIDS. Their current management issues are discussed on the ground of the personal experience, and the most recent literature evidences. PMID- 9951319 TI - [In praise of fallible knowledge (Karl Raimund Popper)]. PMID- 9951321 TI - [A new type of HIV]. PMID- 9951322 TI - [The anti-HIV action of chicoric acid]. PMID- 9951324 TI - [Immunotherapy outside the allergy clinic]. PMID- 9951323 TI - [A new anti-HIV drug]. PMID- 9951325 TI - [Treatment of lupus crisis with IgIV]. AB - BACKGROUND: Intravenous Immunoglobulin (i.v.Ig) has been advocated as efficacious for Systemic Lupus Erytematosus (SLE) and Lupic Nephritis (LN) using high dosages, propitious a prolonged remission of SLE. MATERIAL AND METHOD: We show the case of a male patient 16 years old, with SLE diagnosis until 1993, and LN phase IV. He attend to hospital with a Lupic Crisis, positives ANAs, DNAds, ScL 427, C3 45, C4 13, IgG 179, urinary sediment: leukocytes 30-40 xc, erythrocytes 8 10 xc. Renal failure: BUN 243, seric Cr: 10.16. I.v. Ig administrated 400 mgs k do. And nephrologic assistance, NK. RESULTS: There was improvement after infusion, clinical and serological, persisting with renal failure. The mechanism by which i.v. Ig might have effected improvement in this patient was reviewed. CONCLUSION: The use in our patient with SLE and LN was satisfactory. Is difficult affirm categorical the outcome or failure of i.v. Ig in patients with SLE, even report founded are only few cases report. PMID- 9951326 TI - [Incidence of adverse reactions to immunotherapy in allergic patients at Puebla University Hospital]. AB - MATERIAL AND METHOD: In order to know adverse reaction incidence to, immunotherapy, it realized a longitudinal, prospective and descriptive study in patients of outward consultation of Allergy Immunology Clinic Service of Hospital Universitario de Puebla in a period of 10 months. It determined age, sex, diagnostic, reaction adverse kind and presentation time of them. Initial immunotherapy dose was 0.05 ml administered subcutaneously with treatment antigens 1:100 weight/volume without premedication. It included 170 patients with average age of 22.6 years (SID 15.4), 56.5% female sex and 43.5% male. RESULTS: Most frequent pathologics were asthma and rhinitis. Adverse reactions incidence at specific immunotherapy were 2.4%, all of them were of immediate and local kind. CONCLUSION: These results are influence by the concentration and dose of antigens utilized and may differ of another studies. PMID- 9951328 TI - [Neutrophilic dermatosis]. AB - We present this neutrophilic dermatoses review, showing the importance and pluripotential function of neutrophils: its special proliferation way or its association with immune complexes, that make them express in most different ways, such entities were consider till recently as no related. We are here including uncommon neutrophilic dermatoses, infrequently seen in dermatological departments that make them extremely interesting and a need to be known by dermatologist., looking forward to find new therapeutically concepts. PMID- 9951327 TI - [Diagnostic use of enzymatic RAST skin tests and determination of eosinophils in nasal mucosa in allergic rhinitis]. AB - AIMS: Allergic rhinitis is the most frequent disease mediated by immunoglobulin E (IgE). Nasal challenge is the gold standard for the diagnosis of allergic rhinitis. Skin tests (ST) are the most used diagnostic method to detect the presence of specific IgE bind to skin mast cells. The exposition of the nasal mucous membrane to the allergen is followed by an increase of the local eosinophils; the count of eosinophils in nasal mucous (ENM) is a diagnostic test for allergic rhinitis. Enzymatic RAST or enzymatic allergo-sorbent test (ESA) measures the level of serum allergen-specific IgE. OBJECTIVE: To measure the sensitivity, specificity, and diagnostic precision of ST, EAST and ENM in allergic rhinitis. METHOD: We studied 241 individuals, 162 of them had allergic rhinitis, and 79 were healthy controls. They underwent nasal challenge and intradermic ST for Dermatophagoies spp (acarus). Fraxinus americana (Ash-tree), Amaranthus palmieri (quelite), Cynodon Dactylon (capriola) and Felis catus (cat), EAST for Dermatophagoides pteronyssinus (acarus), and ENIVI. Results of ST, EAST and ENIVI were compared with their corresponding nasal challenge, and the prevalence of allergic rhinitis for each allergen was calculated. The best cut point was assessed by means of receiver-operator curves (ROC), and sensitivity, specificity, positive predictive value, negative predictive value, inter-observer concordance coefficient, area under ROC (0), standard error of 0 (SEO), and 95% confidence interval of 0 of each test were calculated using the best cut point. RESULTS: ST and EAST had the best sensitivity and specificity. ENM had the lowest sensitivity and specificity. CONCLUSION: For the diagnosis of Dermatophagoides spp allergic rhinitis ST for Dermatophagoides spp and EAST for Dermatophagoides pteronyssinus have the same diagnostic precision. According to the indexes for diagnostic precision, and inter-observer concordance coefficient, ST and EAST are useful to diagnose allergic rhinitis induced by the evaluated allergens. ENIVI is a test that is not very useful for the diagnosis of allergic rhinitis. PMID- 9951329 TI - [Pneumonitis due to hypersensitivity in a breast-feeding baby: case report]. PMID- 9951330 TI - [Evaluation of the campaign on vaccination against meningococcal disease in Galicia. Methodology, advantages and disadvantages, Study of carriers]. PMID- 9951331 TI - [Efficacy of seroconversion and duration of immunity induced by the meningococcal serogroup C vaccine. Study included in the evaluation of the mass immunization of the population in the age group between 18 months and 19 years in the community of Madrid]. PMID- 9951332 TI - [Bactericidal activity against Neisseria meningitidis serogroup C in the vaccinated and non-vaccinated population of Andlucia]. PMID- 9951333 TI - [Effectiveness of seroconversion of the Neisseria meningitidis serogroup C vaccine, duration of antibody levels in the Autonomic Community of Extremadura]. PMID- 9951334 TI - [Effect of vaccine in meningococcal disease in Cantabria]. PMID- 9951335 TI - [Methodology of the study of pre- and post-vaccination antibodies against serogroup C Meningococcus]. PMID- 9951336 TI - [Effectiveness of the massive campaign for immunization against Meningococcus (serogroup C) in the Autonomic Community of the Basque Province]. PMID- 9951337 TI - [Interpretation of the laboratory results concerning the protective effect of vaccines]. PMID- 9951338 TI - [Diagnosis of meningococcal disease using PCR]. PMID- 9951339 TI - [Use if PCR for the characterization of strains]. PMID- 9951340 TI - [Meningococcal disease in Spain. Changes in its etiological pattern as an emerging health problem]. PMID- 9951341 TI - [Predictive factors of cases secondary to meningococcal infection in Barcelona. Epidemiology of the disease]. PMID- 9951342 TI - [Search for carriers and characterization of Neisseria meningitidis strains circulating in Extremadura]. PMID- 9951343 TI - [Validation of disease registries for compulsory declaration of meningococcal infections using the capture-recapture method]. PMID- 9951344 TI - [Survey of Neisseria meningitidis carriers in the health resort of the Canary Islands]. PMID- 9951345 TI - [Injury--damages--insurance: legal implications]. AB - Belgian dentists are, during their undergraduate studies, not enough informed on court and insurance procedures in case one of their patients gets injured in an accident or assault. This article focuses on the correct interpretation of some widely used, but often misunderstood, principles. The role of the treating dentist and the dental advisor of the insurer is described and a plea is made for a better cooperation between them, based on honest and correct reporting. PMID- 9951346 TI - [Definitive injuries to the teeth. Lesions of hard tissue and pulp]. AB - Tooth infraction and enamel fracture are the most simple traumatic crown lesions. When necessary the lesions can be covered with composite material. Follow-up of the traumatized tooth is necessary since pulp necrosis and obliteration can develop. In case of an uncomplicated fracture involving enamel and dentine immediate protection of the dentinal wound is important for the preservation of tooth vitality. In case of a negative vitality test, an endodontic treatment will be performed in case of a tooth with open apex only when supplemental clinical and or radiological signs of pulp necrosis are present. When a complicated enamel dentine fracture is present, an endodontic treatment will be performed when root formation is complete. In case of a wide open apex, a pulp capping, partial pulpotomy or cervical pulpotomy will be performed in order to preserve vitality of pulpal tissues at the level of the root. Crown root fractures can be superficial, deep or vertical. In case of a superficial localisation of the fracture line, restoration with composite material or with the fractured tooth segment is indicated. Deep crown-root fractures can only be restored when the fracture line is localized not deeper than at 1/3 of the length of the root. In case of a vertical fracture, extraction is the only possibility. Root fractures on immature teeth are in most cases unilateral and have a good prognosis. In teeth with completed root formation, fractures at the level of the cervix have a poor prognosis. The fractured segment will be removed. Only when the remaining root segment is long enough, this part can be maintained. In case of a fracture at the mid-root level, repositioning and rigid splinting for a period of 8 weeks is necessary. When the tooth becomes non-vital, endodontic treatment is performed on the coronal part. Root fracture in the apical part does not necessary result in enhanced tooth mobility and immobilisation is not always necessary. Healing of a root fracture is only possible when the tooth is immobilized for a sufficiently long period. Regular control of tooth vitality is necessary since pulp necrosis can lead to an inflammatory reaction at the level of the fracture line. PMID- 9951347 TI - [Injuries to the permanent teeth. Periodontal lesions]. AB - Tooth luxations are relatively common. In case of concussion or subluxation the tooth is not displaced. The treatment will consist of relief of the tooth. Most frequent complications are pulp necrosis and obliteration of pulpal tissues. In case of extrusive luxation pulpal tissues and the periodontal ligament are injured. When tooth mobility is increased flexible splinting should be considered. Endodontic treatment is necessary after extrusive luxation of a tooth with completed root formation. Teeth with open apex often show pulpal obliteration after extensive luxation. Lateral luxation is more complex than extrusive luxation since the alveolar bone is also damaged. Repositioning and splinting of the tooth are necessary. When the apical foramen in closed, endodontic treatment will be necessary. Teeth with incomplete root formation will develop pulp obliteration. Following lateral luxation, external root resorption and loss of marginal bone are not infrequent. Intrusive luxation is the type of trauma with most unfavorable prognosis. All intruded teeth will become necrotic and external root resorption and marginal bone loss are frequent. There is no consensus regarding the therapeutic approach. Orthodontic extrusion or surgical mobilisation are possible options. In case of avulsion, both the pulpal tissues and the periodontal ligament are disrupted. Preservation of the vitality of the periodontal ligament covering the root will determine the prognosis of the reimplanted tooth. Therefore the tooth will be repositioned as soon as possible. When this is not possible, milk or a specific solution are most appropriate for tooth conservation. When the reimplanted tooth has complete root formation, devitalization will be performed one week after after repositioning. In case of a tooth with open apex revascularisation can be awaited. Healing of the periodontal ligament will determine prognosis. When a normal ligament is obtained during healing or when surface resorption is obtained, the tooth can be preserved for a long period. When progressive replacement resorption (ankylosis) develops, most teeth can remain in position for about 10 years. When inflammatory resorption develops, the tooth will be lost within a short time. PMID- 9951348 TI - [Fractures of the alveolar process]. AB - Fractures of the alveolar bone plate or processus alveolaris can easily be diagnosed by clinical examination and radiological check-up. These fractures require repositioning and rigid fixation. Pulp degeneration and resorption can be avoided when endodontic treatment is carried out early on. PMID- 9951352 TI - [The International Year of the Elderly 1999]. PMID- 9951351 TI - [The effects of dental collective, group and individual prophylaxis in those who have left school]. PMID- 9951353 TI - [With the age....]. PMID- 9951349 TI - [Maxillo-facial aspects of dento-alveolar trauma]. AB - The management of oral injuries requires expertise in dental and medical cares. The need for a multidisciplinary assessment, including medical, has to be ascertained early. Diagnostic and management procedures are described as well as concomitant lesions such as maxillofacial bony fractures. PMID- 9951350 TI - [The determination of the status of dental implantology in Switzerland]. PMID- 9951354 TI - [Computerized reference management]. PMID- 9951355 TI - [Allergy to dust mites]. AB - House dust mites are the most important indoor allergens in our region. During recent years more dwellings have become infested, most likely as a result of increased indoor humidity due to reduced ventilation. Among Danish adults, 14% have developed IgE against mites. The allergens are stable and can remain for years. Keeping the humidity low (< 45%) during winter months is the most important limiting factor for mite growth. It can be accomplished by ventilation and heating. If bedding, pillow, eiderdown and covering mattress are washedat temperatures > 55 degrees C mites are killed and allergens removed. In addition mattress covers seem to be useful, although guidelines for quality assessment are lacking. Reduction in mite exposure will reduce development of allergy in all age groups especially in the newborn period. Immunotherapy can be offered in rhinitis and moderate asthma when sufficient allergen reduction cannot be accomplished. PMID- 9951356 TI - [House dust mite allergens and mite allergy in Copenhagen dwellings. A cross sectional study]. AB - The aim of the study was to investigate the influence of various environmental factors on occurrence of house dust mite allergens and the influence of allergen exposure on mite allergy. Ninety-two persons from a population study filled in a questionnaire, were skin prick and lung function tested and dust samples were collected from their mattresses for analyses. Two out of five patients with asthma had a positive skin reaction to house dust mite allergen in contrast to five out of 87 non-asthmatics. Fifty-nine per cent of the dust samples contained (group 1) mite allergen > 2 micrograms/g dust. Such mattresses were older (median 7 years, range 1-22) than mattresses with less allergen (median 4 years, range 1 20). In the six bedrooms reported to be humid or mouldy, mattresses contained high concentration of mite allergens. No other parameter investigated could predict the allergen contents. In almost all cases dust analyses are crucial to be able to advise patients with house dust mite allergy. PMID- 9951357 TI - [The effect of traditional Chinese acupuncture on severe tinnitus. A double blind, placebo-controlled clinical study with an open therapeutic surveillance]. AB - The aim of the present study was to determine the effect of intensive acupuncture on severe tinnitus. The structure of the study was a randomized, double-blind, clinical investigation with open therapeutic surveillance and included 54 patients. All were subjected to 25 treatment sessions over a period of two months, each treatment lasting 30 minutes. Fifty-two patients completed the study. The variables used for self-registration were based on the Visual Analogue Scale, where annoyance, loudness and awareness of the tinnitus were assessed. These were recorded twice daily over a four month period starting one month before the first treatment and ending one month after the last treatment. Questionnaires, interviews and audiometry were carried out repeatedly. No statistically significant differences were found between the acupuncture group and the placebo group. PMID- 9951358 TI - [Laparoscopic herniotomy in recurrent inguinal hernia]. AB - We present a material of 103 patients with a total of 105 recurrent inguinal hernias operated by transabdominal laparoscopic repair. Nine patients developed seromas. One was reoperated due to ileus and one had the mesh removed because of persistent pain in the groin. Following a median observation of 12 months (range 4-48 months) 102 patients were examined and two new recurrences were detected corresponding to 1.9% (95% confidence limits 0.2-6.7%). PMID- 9951359 TI - [Latex allergy diagnosed at a department of dermatology. A descriptive analysis of a 3-year material]. AB - This study gives a descriptive analysis of 52 patients with type-I allergy to latex. Seventy-one percent of these cases were considered occupational, especially related to the health care sector (29 of 37 patients). Four patients had to change their jobs because of the allergy. Twenty-five percent presented initially with monosymptomatic contact urticaria, while 35% presented with hand eczema, which could only be explained by concomitant allergy to rubber chemicals in 35% of the cases. During the period from observation of initial symptoms until establishment of the diagnosis, several of the patients with monosymptomatic hand eczema developed additional type-I related symptoms. Not only latex-exposed patients with type-I-related symptoms, but also latex-exposed patients with hand eczema should be suspected for latex-allergy and tested with pricktests, latex specific IgE and skin-provocation tests. PMID- 9951360 TI - [Pacemaker failure in elective DC cardioversion of atrial tachycardia]. AB - A 74-year-old woman with a VVI-rate-responsive pacemaker (Pacesetter 2033K; unipolar pacing electrode) was admitted for cardioversion of atrial tachycardia. Antiarrhythmic medication included flecainide 100 mg x 2. Electrical defibrillation was followed by transient, but severe nodal bradycardia and pacemaker malfunction characterized by loss of ventricular capture and sensing. The incident probably represents an example of pacemaker failure due to an acute increase in the stimulation threshold, most likely caused by current-induced tissue damage at the electrode-endomyocardial interface. Flecainide might have contributed to the increase in stimulation threshold. The clinician should be prepared for the possible consequences of pacemaker failure after external defibrillation. PMID- 9951361 TI - [Hydrothorax caused by intravasal triple-lumen subclavian catheter]. AB - A case in which a patient developed right-sided hydrothorax due to extravasal infusion of total parenteral nutrition (TPN) is reported. The catheter was a triluminal catheter and the tip was shown to be correctly placed in the superior vene cava by x-ray after injection of radio-opaque contrast. The most proximal injection port located 4.5 cm from the tip of the catheter was documented to be sited in the superior mediastinum outside the vena cava. The infusion was given through the proximal port of the catheter. The mechanisms underlying this complication are discussed. The case emphazises the need to control the position of all infusion ports regularly when using central venous catheters with more than one lumen. PMID- 9951362 TI - [The programming hypothesis]. PMID- 9951363 TI - [Picture of the month. Staphylococcal infection with embolizations)]. PMID- 9951364 TI - [The 25th anniversary of the Danish Society of Medical Technology]. PMID- 9951365 TI - [A center for hemoglobin diseases in the county of Copenhagen]. PMID- 9951366 TI - [A tooth per child--myth or reality? Comment on a Danish study]. PMID- 9951367 TI - [Ultrasound screening of pregnant women]. PMID- 9951368 TI - [Heart magnyl]. PMID- 9951369 TI - [Intrathecal opioids in the treatment of postoperative pain]. PMID- 9951370 TI - [Salicylate poisoning--shall the urine be alkalinized and the diuresis forced?]. PMID- 9951371 TI - [Can drugs reduce the need for blood transfusion in the course of surgery?]. PMID- 9951372 TI - [Large prescription forms--great words, but is it necessary?]. PMID- 9951374 TI - [Permeability of blood-eye barrier in patients with primary glaucoma combined with lens opacity]. AB - The development of glaucoma involves changes in the chamber humor caused by hydrodynamic disorders. Primary glaucoma is often combined with lens opacities. Comparison of the content of protein and protein fractions in aqueous humor and blood serum of patients with glaucoma and different degree of lens opacity showed that, in contrast to senile cataract, cataract in a glaucomatous eye forms when the permeability of the blood-eye barrier is increased, which justifies the administration of drugs stabilizing it. PMID- 9951375 TI - [Heparin inhalations and laser exposure of blood in treatment of patients with open-angle glaucoma]. AB - Comparative assessment of methods aimed at amelioration of the immunohemostatic processes in patients with open-angle glaucoma suffering from chronic vascular diseases showed that the most remarkable improvement of the visual functions and decrease of the level of circulating immune complexes in the blood were attained in the patients treated by heparin inhalations combined with intravenous laser exposure of the blood as against patients treated by one of these methods alone or traditionally. PMID- 9951376 TI - [Functional and morphological features of vitreoretinal proliferation after penetrating wounds of eye complicated by hemophthalmos (immunohistochemical and electron microscopy study)]. AB - Comprehensive (optic, electron, and fluorescent microscopy) morphological analysis of vitreous fragments removed in vitrectomy after penetrating wounds of the eye complicated by hemophthalmia showed that blood and damaged cells of pigment-free ciliary epithelium and the glia play an important role in the development of proliferative processes in the ophthalmic cavity. Immunohistochemical studies revealed active expression of immunoglobulins A and G and of HLA-DR antigen on immunocompetent cells and abnormal expression of HLA-DR in pigment-free ciliary epithelium and the glia, confirming the autoimmune origin of inflammatory disorders. PMID- 9951377 TI - [Modern methods of medical rehabilitation in traumatic detachment of retina]. AB - The authors analyze the efficacy of treating patients with vitreoretinal diseases using a pathogenetically-based system of comprehensive medical rehabilitation and the results of ophthalmological examination recorded and processed in a special computer case history. Prognostic analysis making use of nonparametrical statistics method distinguished highly informative signs determining the results of medical rehabilitation in traumatic detachment of the retina. Basic methods of surgical rehabilitation are supplemented with preventive YAG laser surgery. Modern scleroplastic materials are offered. The authors emphasize the significance of two staged adequate postoperative rehabilitation during the immediate postoperative period with special emphasis on the agents regulating redox processes; later YAG lasers and other stimulators can be used. Other perspective trends of research are study of electroenesis and pathogenesis of vitreoretinal proliferation for drug development. PMID- 9951378 TI - [Effect of diabetic encephalopathy on fundus oculi status in diabetes]. AB - Twenty-two diabetics with concomitant diabetic encephalopathy are examined. Control group consisted of 22 diabetics without encephalopathy. In the main group the fundus oculi was normal in 4 (18.2%) patients, common diabetic retinopathy with vascular changes was found in 3 (13.6%), common diabetic retinopathy with exudative and hemorrhagic changes in 7 (31.8%), and descending optic nerve atrophy in 8 (36.4%); two of these latter patients developed diabetic retinopathy, although little expressed. The fundus oculi was abnormal in all controls. Common diabetic retinopathy with hemorrhagic and exudative changes was observed in 12 (54.5%) and proliferative diabetic retinopathy in 10 (45.5%) patients. Diabetic encephalopathy concomitant with diabetes mellitus prevents or delays the development of diabetic retinopathy. The mechanism of this phenomenon is discussed. The "parquet" pattern of the fundus oculi can be an important differential diagnostic sign of diabetic and dyscirculatory encephalopathy. PMID- 9951379 TI - [Effects of corticosteroid and nonsteroid antiinflammatory drugs on corneal transparency after photorefraction keratectomy]. AB - Effects of corticosteroid and nonsteroid antiinflammatory drugs on corneal transparency after photorefraction keratectomy (PFK) in myopia are studied. Corneal transparency was assessed by computer analytical system for the anterior segment of the eye, designed by the authors. Corticosteroids (0.1% dexamethasone solution) more effectively control bacterial contamination of the cornea in high myopia than nonsteroids (0.1% sodium diclofenac solution). A significant improvement of optic density of the cornea was observed 2 weeks after PFK when corticosteroids were discontinued. On the other hand, replacement of diclofenac with dexamethasone 2 weeks after PFK did not result in decrease of optic density of corneal image. Apparently, corticosteroids contribute to decrease of bacterial contamination of the cornea during the very first days after PFK. In myopia of up to -6.0 diopters, the densitometric parameters were virtually the same in the patients treated with nonsteroids and corticosteroids. PMID- 9951380 TI - [Vitasic magnetophoresis in the treatment of primary reticular corneal dystrophy]. AB - Sixty-six patients (132 eyes) with hereditary reticular corneal dystrophy were treated by instillations of taufon and vitasik eyedrops and by vitasik magnetophoresis. Time course of clinical symptoms and visual acuity is compared. Vitasik is better tolerated and its therapeutic effect is higher than that of taufon. The efficacy of vitasik is still more increased by magnetophoresis ensuring the best results. PMID- 9951382 TI - [Sclera-fortifying treatment of myopia in children at high risk of its progression]. AB - The paper deals with progress of myopia during active growth of children. The strategy of treatment is developed and efficacy of surgical fortification of the sclera in children with an unfavorable course of myopia (early acquired myopia, rapid progress of the condition) is assessed. The proposed method stabilizes myopia for 3 years sclera fortification carried out in several stages in the patients with the most grave condition. Practical recommendations are offered concerning a certain order of exposures and indications for them. PMID- 9951381 TI - [Efficacy and indications for YAG laser optico-reconstructive surgery on the anterior eye segment in children]. AB - Efficacy of YAG laser surgery is analyzed in 486 children treated at the Helmholtz Institute of Ocular Diseases. Indications and contraindications for YAG laser correcting opticoreconstructive surgery on the anterior segment of the eye are defined for children with secondary cataracts, some congenital, traumatic, and complicated cataracts, anterior and posterior synechias, goniosynechias, ectopic and pinhole pupil, pupil block, anterior chamber cysts, vitreous adhesions, and some consequences of intraocular lens implantation. Optimal terms of laser intervention are defined, improving its efficacy and decreasing the risk of complications. PMID- 9951383 TI - [Method of prevention and treating the accommodation cramp and progressive myopia in children]. AB - A new method for treating the accommodation cramp and progressive myopia in children consists in transferring the glance from a close TV screen to a far one. One of the tasks of this method is to turn a computer game from a factor deteriorating the accommodation into a factor improving it. The picture is automatically transferred from one TV to the other every 10 seconds. Sixty-five children were followed up. The volume of relative accommodation improved, the progress of myopia in a year was 0.045 versus 0.5 diopters in the control group. PMID- 9951384 TI - [Combined method for treating false myopia and preventing axial myopia]. AB - None of the numerous methods for optic and drug treatment of the accommodation cramp effectively arrests it without long tiresome training or atropine, which limits visual working capacity for a long time and therefore, precludes starting the treatment on an outpatient basis immediately. Use of an available, simple, and effective combined method for treating the accommodation cramp helped prevent true myopia in 94.3% of young children in the main group, whereas 38.3% children in the control group developed myopia. PMID- 9951385 TI - [Vitrectomy: method for treating of vitreo-corneal adhesions in children]. AB - Vitreocorneal adhesions were removed by anterior vitrectomy in 37 children. In 19 patients the adhesions developed after removal of cataracts and in 18 after penetrating wounds of the cornea. Vitrectomy was carried out 1 month to 6 years after the diagnosis, the mean term was 1.4 years. The intervention normalized the ratio between ocular chambers, improved the appearance, and appreciably improved the visual acuity. PMID- 9951386 TI - [Microcirculatory bed of bulbar conjunctiva and fundus oculi vessels in cervical osteochondrosis]. AB - A total of 100 patients (200 eyes) with cervical osteochondrosis were examined. Microcirculatory bed of the bulbar conjunctiva, pressure in the central retinal artery, and diameter of vessels in the fundus oculi were assessed. All these parameters were disordered in the examinees in comparison with normal controls. The degree of changes inversely correlated with clinical manifestations of cervical osteochondrosis. Study of ocular hemodynamics in this patient population helps predict the time course of the underlying disease. PMID- 9951387 TI - [Comparative assessment of antioxidant activity of para-aminobenzoic acid and emoxipin in retina]. AB - Effect of para-aminobenzoic acid (PABA) on lipid peroxidation (LPO) in rat and guinea pig retina exposed to hypoxic hypoxia is studied. PABA was injected intraperitoneally and parabulbarly before and after hypoxic exposure. Antioxidant activities of PABA and emoxipin were compared. An intraperitoneal injection of PABA in a dose of 10 mg/kg 24 h before hypoxia virtually completely prevented accumulation of lipid peroxides and preserved catalase activity in the retina. Parabulbar injection of 0.01% PABA solution 1 h before hypoxia prevented LPO intensification, stabilized catalase activity in hypoxia, and protected the retina starting from the moment immediately after hypoxic exposure. The efficacy of 0.01% PABA is comparable with that of 1% emoxipin, and a 0.01% solution of emoxipin is less effective than PABA in the same concentration. PABA exerts an antioxidant effect after hypoxia by decreasing the abnormally high level of lipid peroxides and reducing catalase activity in the retina after parabulbar injection of the drug. All the studied concentrations of the drug (from 0.007 to 0.08%) are active, but the optimal dose for the retina is 0.04%. By its efficacy this concentration is equivalent to 1% emoxipin. PMID- 9951388 TI - [Results of psychological testing of patients with keratoconus]. AB - Psychological testing of 63 normal subjects and 84 patients with keratocone was carried out separately for men and women aged 18-64 years using 11 scores of a brief multifactorial questionnaire for personality examination (BMQP). Comparison of averaged profiles of examined men and women with keratocone showed features of sensitive and psychasthenic personalities. According to BMQP scores, the population of men with keratocone is characterized by increased levels of psychasthenia and schizophrenia, whereas women develop depression, psychasthenia, and schizophrenia. PMID- 9951389 TI - [Combined treatment of postoperative inflammations after intraocular lenses implantation]. AB - Laser exposure was used for treating some postoperative complications in 11 patients. The results indicate a high efficacy of YAG and argon laser in multiple modality treatment of exudative reactions developing after implantation of intraocular lenses. PMID- 9951390 TI - [Case of left ethmoidal labyrinth mucocele simulating chronic purulent dacryocystitis]. PMID- 9951391 TI - [Expanders in plastic ophthalmologic surgery]. PMID- 9951392 TI - [Triple procedure]. PMID- 9951393 TI - [Ozone therapy in ophthalmology]. PMID- 9951395 TI - Self-organization of the heartbeat as coordination among ventricular myocardial cells through mechano-electrical feedback. AB - To elucidate the mechanism of the self-organizing control of heartbeats, models that include the electrical and mechanical processes of heartbeat are proposed. As the mutual interaction between the two processes, mechano-electrical feedback (MEF), mediated by stretch-activated ionic channels, is considered. Analyses of the models show that coordination of beats among myocardial cells is established by MEF even in the absence of electrical coupling. The coordination of heartbeats is found to show in-phase synchronization under normal conditions, while it is out of phase or irregular under mechanically abnormal conditions. It is concluded that coupling by MEF is important for the self-organization of heartbeats. PMID- 9951394 TI - [Clinical course of diabetic retinopathy in myopia]. PMID- 9951396 TI - Bayesian inference in populations of cortical neurons: a model of motion integration and segmentation in area MT. AB - A major issue in cortical physiology and computational neuroscience is understanding the interaction between extrinsic signals from feedforward connections and intracortical signals from lateral connections. We propose here a computational model for motion perception based on the assumption that the local cortical circuits in the medio-temporal area (area MT) implement a Bayesian inference principle. This approach establishes a functional balance between feedforward and lateral, excitatory and inhibitory, inputs. The model reproduces most of the known properties of the neurons in area MT in response to moving stimuli. It accounts for important motion perception phenomena including motion transparency, spatial and temporal integration/segmentation. While integrating several properties of previously proposed models, it makes specific testable predictions concerning, in particular, temporal properties of neurons and the architecture of lateral connections in area MT. In addition, the proposed mechanism is consistent with the known properties of local cortical circuits in area V1. This suggests that Bayesian inference may be a general feature of information processing in cortical neuron populations. PMID- 9951397 TI - Activity-dependent enhancement in the reliability of correlated spike timings in cultured cortical neurons. AB - To study the use-dependent modification of activity in neural networks, we investigated the spike timing by simultaneously recording activity at multiple sites in a network of cultured cortical neurons. We used dynamical analysis to study the temporal structure of spike trains and the activity-dependent changes in the reliability and reproducibility of spike patterns evoked by a stimulus. We also used cross-correlation analysis to evaluate the interactions of neuron pairs. Our main conclusions are that even when no obvious change in spike numbers can be seen, use-dependent modification occurs, either enhancing or reducing in the reliability and reproducibility of spike trains evoked by a stimulus, and the fine temporal structure of stimulus-evoked spike trains and interactions between neurons are also modified by tetanic stimulation. PMID- 9951398 TI - Investigation of the dynamics underlying periodic complexes in the EEG. AB - Periodic complexes (PC), occurring lateralised or diffuse, are relatively rare EEG phenomena which reflect acute severe brain disease. The pathophysiology is still incompletely understood. One hypothesis suggested by the alpha rhythm model of Lopes da Silva is that periodic complexes reflect limit cycle dynamics of cortical networks caused by excessive excitatory feedback. We examined this hypothesis by applying a recently developed technique to EEGs displaying periodic complexes and to periodic complexes generated by the model. The technique, non linear cross prediction, characterises how well a time series can be predicted, and how much amplitude and time asymmetry is present. Amplitude and time asymmetry are indications of non-linearity. In accordance with the model, most EEG channels with PC showed clear evidence of amplitude and time asymmetry, pointing to non-linear dynamics. However, the non-linear predictability of true PC was substantially lower than that of PC generated by the model. Furthermore, no finite value for the correlation dimension could be obtained for the real EEG data, whereas the model time series had a dimension slighter higher than one, consistent with a limit cycle attractor. Thus we can conclude that PC reflect non linear dynamics, but a limit cycle attractor is too simple an explanation. The possibility of more complex (high dimensional and spatio-temporal) non-linear dynamics should be investigated. PMID- 9951399 TI - The role of cortical area MST in a model of combined smooth eye-head pursuit. AB - The cortical medial superior temporal area (MST) is essential for the normal execution of smooth pursuit eye movements. Many pursuit-related neurons (visual tracking neurons = VT neurons) in the lateral part of area MST (MSTl) are responsive to retinal image slip (r) as well as to eye (e) and head velocity (h) with similar preferred directions (isodirectionality). We show, by running a connectionist network with VT neuron-like elements, that an assembly of MSTl-VT neurons is able to reconstruct target motion in world-centered coordinates (t'). When t' is fed into a subsequent model stage, converting t' into gaze velocity (g') with varying contributions of e and h, the overall model is able to account for many of the salient properties of visually guided pursuit including the consequences of MSTl lesions. However, the analysis of the MSTl network also clearly indicates that isodirectionality is not a prerequisite for its performance. The investigation of a second model suggests that isodirectionality indeed does not result from functional but from developmental constraints. This second model is a connectionist network with hidden units, which similar to MSTl VT neurons receive input from modality specific units encoding retinal slip, eye and head velocity. After training this network to offer t' as output, two subsets of hidden units emerged, one exhibiting isodirectionality, but not the other. Since only isodirectional hidden units contributed to the flow of information, the preponderance of isodirectional MSTl-VT neurons might be the result of developmental pruning, eliminating the second group. PMID- 9951400 TI - Enantioselective analysis of N-hydroxymexiletine glucuronide in human plasma for pharmacokinetic studies. AB - Enzymatic hydrolysis with beta-glucuronidase/sulfatase was used for the enantioselective determination of N-hydroxymexiletine glucuronide in plasma for pharmacokinetic studies. N-Hydroxymexiletine glucuronide was determined as the quantity of mexiletine released by hydrolysis (difference between the enantiomeric concentrations of mexiletine obtained with and without hydrolysis). Plasma samples (100 microliters) were treated at pH 5.0 with 10 mg of the enzyme (Limpet Acetone Powder type I) for 16 hr at 37 degrees C and extracted at pH 10.4 with diisopropyl ether. Chiral mexiletine discrimination was obtained by reaction with o-phthalaldehyde/N-acetyl-L-cysteine, separation of the resulting diastereomers on a C-18 reversed-phase column with a mobile phase of methanol 0.05 N acetate buffer, pH 5.5 (6.5:3.5, v/v), and fluorescence detection (lambda ex 350 nm, lambda em 455 nm). The performance characteristics for the enantioselective analysis of mexiletine preceded by enzymatic hydrolysis were recovery approximately 90%, quantification limit 1 ng/ml, and linearity up to 1000 ng/ml plasma for both enantiomers. The coefficients of variation obtained in the study of intra- and inter-day precision were respectively 5% and 7% for both enantiomers. The assay was shown to be suitable for a pharmacokinetic study performed in a patient with the arrhythmic form of chronic Chagas' heart disease treated with 200 mg t.i.d. of racemic mexiletine hydrochloride. The high sensitivity of the method allows analysis of only 100 microliters plasma. PMID- 9951401 TI - Stereoselective disposition of tiaprofenic acid enantiomers in rats. AB - The pharmacokinetics and metabolic chiral inversion of the S(+)- and R(-) enantiomers of tiaprofenic acid (S-TIA, R-TIA) were assessed in vivo in rats, and in addition the biochemistry of inversion was investigated in vitro in rat liver homogenates. Drug enantiomer concentrations in plasma were investigated following administration of S-TIA and R-TIA (i.p. 3 and 9 mg/kg) over 24 hr. Plasma concentrations of TIA enantiomers were determined by stereospecific HPLC analysis. After administration of R-TIA it was found that 1) there was a time delay of peak S-TIA plasma concentrations, 2) S-TIA concentrations exceeded R-TIA concentrations from approximately 2 hr after dosing, 3) Cmax and AUC(0-infinity) for S-TIA were greater than for R-TIA following administration of S-TIA, and 4) inversion was bidirectional but favored inversion of R-TIA to S-TIA. Bidirectional inversion was also observed when TIA enantiomers were incubated with liver homogenates up to 24 hr. However, the rate of inversion favored transformation of the R-enantiomer to the S-enantiomer. In conclusion, stereoselective pharmacokinetics of R- and S-TIA were observed in rats and bidirectional inversion in rat liver homogenates has been demonstrated for the first time. Chiral inversion of TIA may involve metabolic routes different from those associated with inversion of other 2-arylpropionic acids such as ibuprofen. PMID- 9951402 TI - Stereoselective allosteric binding interaction on human serum albumin between ibuprofen and lorazepam acetate. AB - The effect of ibuprofen enantiomers on the stereoselective binding of 3-acyloxy 1,4-benzodiazepines to human serum albumin (HSA) was studied using both native and Sepharose-immobilized protein. (S)-Lorazepam acetate exhibited considerably enhanced binding, especially in the presence of (+)-(S)-ibuprofen. The phenomenon is an indication of cooperative allosteric interaction between different binding sites during multiple cobinding of two ligands. PMID- 9951403 TI - Stereoselective binding of zopiclone to human plasma proteins. AB - The binding of racemic zopiclone (ZOP) and of its two enantiomers to plasma proteins, albumin and alpha 1-acid glycoprotein were compared. Our work shows that the binding of ZOP to human plasma proteins is stereoselective. The total plasma protein binding percentages were 79.3 +/- 5.5%, 83.8 +/- 5.2%, and 75.1 +/ 2.1%, for racemic zopiclone, (-)zopiclone and (+)zopiclone, respectively. These results were confirmed by the analysis of samples obtained from healthy volunteers after the oral administration of ZOP. The anticoagulant used for sampling was also shown to have an influence on the percentage binding and on its stereoselectivity. Considering albumin and alpha 1-acid glycoprotein separately, stereoselectivity was also observed. PMID- 9951404 TI - Syntheses and beta-adrenergic binding affinities of (R)- and (S) fluoronaphthyloxypropanolamines. AB - The beta-adrenergic receptors mediate several physiological processes including heart rate (beta 1), bronchodilation (beta 2), and lipolysis (beta 3). Therefore, selectivity is important for a possible therapeutic agent acting via these receptors. Aryloxypropanolamines are beta-receptor agonists or antagonists, depending on the aryl group and its substituents. We therefore hypothesized that fluorine substitution on the aromatic ring in this class could lead to significant biological effects because of the unique chemical characteristics of fluorine. Because the target compound has a chiral center, we set out to synthesize the two enantiomers so that effects of stereochemistry on biological activity could be evaluated. Syntheses of the enantiomers were performed starting with commercially available fluoronaphthalene and subsequent use of the chiral synthon (2R)- or (2S)-glycidyl 3-nitrobenzenesulfonate, depending on the desired enantiomer. High-pressure liquid chromatography (HPLC) methods were used to characterize %ee. Each enantiomer was synthesized. They exhibited nanomolar binding activities on beta-adrenergic receptors. The (S)-enantiomer was found to be up to 310 times more potent than the (R). It was also found to be about five fold more selective for beta 2- than for beta 1-receptors. The current report demonstrates the importance of stereochemistry for the fluoroaromatic beta receptor ligands. PMID- 9951405 TI - Stereospecific N-methylation of the tetrahydroisoquinoline alkaloids isosalsoline and salsolidine by amine N-methyltransferase A from bovine liver. AB - Stereospecific N-methylation of the tetrahydroisoquinoline alkaloids isosalsoline (7-hydroxy-6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) and salsolidine (6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) by amine N methyltransferase A isolated from bovine liver is reported. Incubation with S adenosylmethionine as cosubstrate revealed that in case of isosalsoline, an endogenous tetrahydroisoquinoline alkaloid, the (+)-(R)-enantiomer, is preferentially methylated, whereas in the case of salsolidine the (-)-(S) enantiomer is preferentially methylated. The results were obtained by using two independent methods, namely a radioassay and HPLC following separate incubation experiments. PMID- 9951406 TI - Alcohol-induced stimulation and sedation: relation to physical aggression. AB - The relation between the stimulating and the sedating effects of acute alcohol consumption on human physical aggression was examined. Sixty male social drinkers were assigned to either an alcohol or a sober group. Aggression was measured using a modified version of S. Taylor's (1967) aggression paradigm, in which electric shocks are received from and administered to a fictitious opponent during a competitive task. Aggression was operationalized as the intensity and the duration of the shocks selected. Stimulation and sedation were measured using a self-report inventory. Results demonstrated that stimulation was positively related to aggression, but only in the intoxicated state. Sedation was not related to aggression in either the intoxicated or the sober state. PMID- 9951407 TI - Age stereotyping at work: the role of rater and contextual factors on evaluations of job applicants. AB - Using refinements of hypotheses by L. M. Finkelstein, M. J. Burke, and N. S. Raju (1995), the authors examined the effects of rater age, age salience, and job relevant information on 324 managers' ratings of an older or a younger hypothetical applicant's interpersonal skills, economic worth, and likelihood of being interviewed. They hypothesized that age identity would interact with age salience to produce ingroup biases that would lead raters to favor workers from their own age groups. There was a main effect of target age on all dependent variables, with the strongest effects on the ratings of economic worth: The participants rated the older target as less economically beneficial than the younger target. When age was highly salient and when the raters identified psychologically with their age groups, older raters actually disfavored older workers in ratings of economic worth. The authors also discuss directions of future research into the roles of the target's economic worth and the rater's age identity in age stereotyping and age discrimination in employment decisions. PMID- 9951408 TI - Effects of atropine on measures of behavioral arousal in rats. AB - Forty-day-old rats were given varying doses (0.0, 7.5, or 15.0 mg/kg/5 ml) of atropine sulfate or atropine methylnitrate and then were tested for levels of behavioral arousal-inhibition. Behavioral measures included transport response intensity, vertical cling catalepsy duration, and dorsal immobility duration. Atropine sulfate produced large increments in transport response intensities, and atropine methylnitrate produced intermediate effects, compared with saline treated control rats. No drug effect was reported for the measures of vertical cling catalepsy or dorsal immobility. Intraclass correlations among the various behavioral measures in this study revealed a reliable relationship between dorsal immobility duration and transport response intensity in the saline group. Administration of either the methylnitrate or sulfate solution negated this relationship. Results are discussed with respect to (a) possible mechanisms relating dorsal immobility and transport response and (b) reasons for the loss of relationship between the two measures with administration of atropine solutions. PMID- 9951409 TI - Individual differences in arousal and accessibility to information in memory. AB - The authors conducted 9 experiments to test the hypothesis (S. Schwartz, 1975) that arousal influences the accessibility of information stored in memory. They investigated the relationship between arousal levels (as indexed by personality types) and the type of stimuli or cues presented during study or test. They predicted that low-arousal individuals (stable extraverted individuals in Experiments 1-3 and 5-9 and high-impulsive individuals in Experiment 4) would be influenced by semantic stimuli, whereas high-arousal individuals (neurotic introverted individuals in Experiments 1-3 and 5-9 and low-impulsive individuals in Experiment 4) would be influenced by physical (i.e., graphic, phonetic, or both) stimuli. They tested the arousal-accessibility hypothesis by using a variety of tasks including verbal discrimination, false recognition, cued recall, and paired associates. With the exception of the finding that stable extraverted participants performed better than neurotic introverted participants on an incidental associative-matching task (Experiment 3), the results from the verbal discrimination studies (1-5) did not support the hypothesis. In Experiment 6, the authors tested the hypothesis by using a false-recognition task. False alarms varied as a function of phonetic and semantic stimuli, but personality types were not differentially sensitive to the manipulation. The same was true for the cued recall studies (Experiments 7 and 8); personality types were not differentially sensitive to the semantic and phonetic stimuli. Experiment 9 (paired-associate learning) was a replication of Schwartz's study. The authors found some support for the Schwartz hypothesis: Extraverted participants were adversely affected by semantic similarity. Overall, the findings did not provide much support for the arousal-accessibility hypothesis. PMID- 9951410 TI - Mass spectrometric analysis of lipo-chitin oligosaccharides--signal molecules mediating the host-specific legume-rhizobium symbiosis. AB - Lipo-chitin oligosaccharides (LCOs) are novel bacterial glycolipid signal molecules that mediate the species--specific symbiosis between rhizobial bacteria and leguminous plants. Nodulation of the legume roots and nitrogen-fixation in the resulting nodules by Rhizobia is controlled by the bacterial nodulation genes that encode the LCO biosynthetic enzymes. The length of the LCO chitin backbone, the length and degree of unsaturation of the fatty acyl chain attached to it, and the combination of different chemical substituents on the reducing- and nonreducing-terminal residues all contribute to the species--specificity of the signal. LCOs are bioactive in the nanomolar and subnanomolar concentration range and are produced as heterogeneous mixtures, making determination of their structures a difficult task, most successfully approached by the application of modern mass spectrometric methods in combination with specific chemical treatments aimed at identifying specific chemical moieties. This review presents an overview of these methods as they are being used for the structural elucidation of LCOs, and discusses the role of structural diversity in mediating species-specificity. PMID- 9951411 TI - Profiling of 2-aminoacridone derivatised glycans by electrospray ionization mass spectrometry. AB - Three different types of N-glycans, high-mannose, complex and hybrid, have been derivatised with 2-aminoacridone and analysed by electrospray mass spectrometry and tandem mass spectrometry (MS/MS) using a hybrid quadrupole orthogonal acceleration time-of-flight mass spectrometer, fitted with a nanoflow electrospray ion source. Relatively simple MS/MS fragmentation patterns have been observed for each type of glycan, allowing rapid elucidation of the order in which the monosaccharide residues making up these glycans are linked to one another. PMID- 9951412 TI - Accurate mass determinations for the confirmation and identification of organic microcontaminants in surface water using on-line solid-phase extraction liquid chromatography electrospray orthogonal-acceleration time-of-flight mass spectrometry. AB - The identification of polar microcontaminants in surface water is an important issue in environmental analysis. Liquid chromatography/mass spectrometry (LC/MS) is frequently applied for this purpose. However, even in combination with tandem mass spectrometry (MS/MS), unambiguous identification of the compounds detected is often difficult. The potential of an alternative strategy, based on the ability of an orthogonal-acceleration time-of-flight mass spectrometer to routinely perform accurate mass determination at 10 ppm in on-line LC/MS, is explored. On-line solid-phase extraction LC electrospray orthogonal-acceleration time-of-flight mass spectrometry is shown to enable the determination of pesticides from various compound classes in surface water in the concentration range of 0.1 to 10 micrograms/L. In addition, the ability to discriminate and unambiguously identify pesticides in mixtures of isobaric and/or isomeric compounds is investigated. PMID- 9951413 TI - Role of urinary and cloacal bladders in chelonian water economy: historical and comparative perspectives. AB - The Parisian comparative anatomist Claude Perrault, dissecting an Indian giant tortoise in 1676, was the first to observe that the urinary bladder is of an extraordinary size in terrestrial tortoises. In 1799, the English comparative physiologist Robert Townson suggested that the bladder functioned as a water reservoir, as he had shown previously for frogs and toads. However, these observations went unnoticed in subsequent reports on tortoise water economy that were made by travellers and naturalists visiting the Galapagos Archipelago and marvelling over the huge numbers of giant tortoises that inhabited these desert like islands. The first such report was by an American naval officer, David Porter, who was a privateer in the 1812-15 war with England. In his journal he referred to the constant supply of water which the Galapagos tortoises carried with them. References to the location in the body, as well as the amounts and quality of the water stored, were, however, contradictory. The confusion concerning the anatomical identity of the water reservoir in the Galapagos tortoise, Geochelone elephantopus, persisted throughout the nineteenth century, and continued when studies of tortoise water economy and drinking behaviour in arid environments were taken up independently in the desert tortoise, Gopherus agassizii, which inhabits the desert regions in the south-western United States. In 1881 Cox found large sacs filled with clear water under the carapace, but it was half a century later that these sacs were identified as the large bilobed bladder; references to specific water sacs continued to appear in the literature until the 1960s. Since 1970, information on the water economy of desert tortoises has been obtained from extensive field studies. Rates of disappearance of tritiated water injected into the body have shown that during the drought periods of the summer, water turnover (intake) rates do not differ from the rates of metabolic water production. Under these conditions urine is not voided, but is stored in the large bladder. During a drought period the bladder urine increases from initially low osmolality finally to reach isosmolality with the blood plasma. Soluble K+ is the major cation of the urine, but large amounts of K+ are also present as precipitated urates. During a drought period the body is in negative water balance, but despite substantial losses of total body water, the plasma concentrations of Na+ and Cl- can remain constant for many months, indicating regulation of the extracellular fluid and water content of the body tissues by reabsorption of water from the urinary bladder. The bladder thus acts both as a store for nitrogenous waste and K+ and as a water reservoir during droughts. Following rain showers, there is a sharp decline in tritium activity correlated with copious drinking from temporary pools of rain water. The old bladder urine is voided and most of the water drunk is stored as a highly dilute urine. In 1676 Perrault observed that in a freshwater turtle, Emys orbicularis, but not in the giant tortoise, two other bladders opened into the cloaca. By the mid-twentieth century it had been established that these cloacal bladders typically were restricted to species of chelonians that led a semi-terrestrial or semi-aquatic life. The function of the bladders has been debated since Townson observed in 1799 that dehydrated freshwater turtles took up water by anal drinking, suggesting that anal drinking served in the water economy of semi terrestrial turtles. Since then, the bladders have been ascribed hydrostatic and respiratory functions, but the recent literature mostly argues for a respiratory function. The possible role of the cloacal bladders as a water reservoir in amphibious turtles is still open. Terrestrial amphibians and tortoises are unique among vertebrates in possessing large urinary bladders that may function as water reservoirs in dry environments. (ABSTRACT TRUNCATED) PMID- 9951414 TI - Frugivory and seed dispersal by vertebrates in the Oriental (Indomalayan) Region. AB - Current knowledge of frugivory and seed dispersal by vertebrates in the Oriental Region is summarized. Some degree of frugivory has been reported for many fish and reptile species, almost half the genera of non-marine mammals and more than 40% of bird genera in the region. Highly frugivorous species, for which fruit dominates the diet for at least part of the year, occur in at least two families of reptiles, 12 families of mammals and 17 families of birds. Predation on seeds in fleshy fruits is much less widespread taxonomically: the major seed predators are colobine monkeys and rodents among the mammals, and parrots, some pigeons, and finches among the birds. Most seeds in the Oriental Region, except near its northern margins, are dispersed by vertebrate families which are endemic to the region or to the Old World. Small fruits and large, soft fruits with many small seeds are consumed by a wide range of potential seed dispersal agents, including species which thrive in small forest fragments and degraded landscapes. Larger, bigger-seeded fruits are consumed by progressively fewer dispersers, and the largest depend on a few species of mammals and birds which are highly vulnerable to hunting, fragmentation and habitat loss. PMID- 9951416 TI - Nitrogen dioxide in Australian homes: levels and sources. AB - Indoor nitrogen dioxide exposure has been associated with respiratory symptoms in children in many studies, but in Australia, levels and sources of nitrogen dioxide in homes have not been well-characterized. Therefore, as part of a larger indoor environmental study, conducted in the Latrobe Valley, Victoria, nitrogen dioxide was monitored using passive samplers in 80 homes. Samples were collected on five occasions over one year. Mean indoor levels were higher than outdoor levels, and a seasonal variation was evident, with highest levels recorded in winter. The overall median level was 11.6 micrograms/m3 (6.0 ppb), ranging from < 0.7 to 246 micrograms/m3 (128 ppb). Major indoor nitrogen dioxide sources were: gas stoves, vented gas heaters, and smoking. Some 67% of variation in indoor nitrogen dioxide levels could be explained by presence of major sources, house age, and outdoor levels. Gas stoves were the main contributors. PMID- 9951418 TI - [Medical continuing education in oncology. The Editorial Committee]. PMID- 9951417 TI - Ozone-monitoring in Mendoza, Argentina: initial results. AB - A series of continuous ambient tropospheric ozone measurements were taken in Mendoza, Argentina, for a period of one year starting in November 1995. The data obtained were analyzed in terms of diurnal and annual variation. Indications were found of the strong impact of the mountain-valley circulation system, which ventilates and considerably cleans the air in Mendoza. The data are discussed in comparison with air pollution in the German city of Leipzig. In Mendoza, the high concentration of precursors and the strong solar radiation contribute to high levels of ozone. In fact, monitoring reveals considerably lower concentrations than in Leipzig, owing to the diluting effect of local meteorology. The low-level jet is mainly active during the summer. It lowers the peak mid-day ozone concentration and produces a temporary concentration increase at night. The Environmental Protection Agency standard of a maximum one-hour mean concentration of 0.250 mg ozone/m3 (125 ppb) is never reached, and the World Health Organization standard of 0.113 mg ozone/m3 (56.5 ppb) is only rarely exceeded during winter. PMID- 9951419 TI - [The role of APC in colonic cancerogenesis: zeroing in on Myc]. AB - The APC gene is mutated both in familial adenomatous polyposis (FAP) and sporadic colorectal cancers. It had been previously shown that the APC gene product interacts with beta-catenin, a key element in the Wnt-1 signaling pathway. This pathway is initiated by the growth factor Wnt-1 and ends up in the nucleus where it activates transcription factors of the Lef/Tcf family although the targets of the latter were still unknown. This has just been accomplished by the identification of the c-MYC oncogene as the relevant target of the Wnt-1/APC pathway in the development of human colorectal cancers. Indeed, under appropriate conditions (presence of growth factors, for example), c-MYC is an essential determinant of cell proliferation. PMID- 9951420 TI - [Methodology and limitations of pre-clinical models for the development of anticarcinogenic chemotherapy combinations]. AB - In chemosensitive tumors, cancer chemotherapy is active as drug combinations. During the development of new anticancer drugs, preclinical experimental models may help to design drug combinations. Indeed, in vitro models are able to define drug interactions in terms of synergism, additivity or antagonism, while in vivo models can evaluate therapeutic synergism along with toxicity in a clinical setting. The methodology for in vitro and in vivo evaluation of anticancer drug combinations is described. The limits are discussed. In conclusion, preclinical models contribute to the clinical development of drug combinations which are nevertheless designed on the basis of clinical therapeutic principles. PMID- 9951421 TI - [Positron emission tomography (PET) and (F-18)-fluorodeoxyglucose in (FDG) in cancerology]. AB - Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) is a scintigraphic imaging technique undergoing a rapid growth in the field of oncology. The constant progress of the detectors, either CDET or PET dedicated cameras, allows to obtain in routine conditions images with a 5 mm spatial resolution. Absolute tracer uptake quantification is also possible, which allows to evaluate objectively therapy efficacy. The mechanisms of FDG tissular accumulation are now better understood. Increase of glycolysis and of transmembrane transport of glucose seems to be at the origin of the high tumorous accumulation of FDG. The main current oncologic application of FDG PET is the diagnosis of malignancy of the isolated pulmonary nodules, with a sensitivity of more than 95%, and in the staging of lung cancer where PET shows higher performances than conventional imaging. The same stands in cutaneous melanoma and for malignancies of the digestive tract, either in colorectal, pancreatic or esophageal localizations. In colorectal cancers, the role of PET has for long being recognized in the differential diagnosis between recurrence and postoperative fibrosis. In the head and neck tumors, FDG also allows to differentiate between recurrence and postradiation necrosis. In lymphoma, the most suitable site for biopsy can be identified on a PET scan and therapy efficacy can also be assessed. In breast cancer, the detection of metastases seems to be possible with FDG. In brain and thyroid cancers, the role of FDG PET remains to be further determined. The low uptake of FDG in prostate cancer metastasis is not in favor of its use in this indication. In conclusion, the indications of FDG PET in oncology are now becoming more precise and it can be expected that clinical PET centers will soon appear in France. PMID- 9951422 TI - [Use of antibodies or their fragments for the treatment of tumors]. AB - During the last 15 years, various antibodies specific for antigens associated with determined types of cancer have been used therapeutically, including some in unlabeled forms as immune effectors. The results of clinical studies have been unpromising for patients with colorectal cancer at the advanced metastatic stage but much more favorable in terms of increased survival for the adjuvant situation of residual microscopic disease. Antibodies have also been used as carriers for cytotoxic substances, but with rather disappointing clinical results when they were labeled with toxins or antimitotic agents. The results have been variable for labeling with radionuclides (mainly iodine-131), some-times proving quite favorable for refractory forms of non-hodgkin's lymphomas or acute leukemias. In this last indication, radioimmunotherapy has been associated with chemotherapy to enhance action before a bone-marrow graft. However, the clinical results have been disappointing in the treatment of solid tumors, showing responses only in the case of small targets. In the future, treatment with antibodies will focus on microscopic tumors, in association with other therapeutic modalities especially, chemotherapy and biotherapy. PMID- 9951423 TI - [Adjuvant treatment of cancer of the breast: cost assessment of the protocol used]. AB - In this study a cost analysis of therapeutics used in the adjuvant treatment of breast cancer has been performed. Four strategies were considered: chemotherapy (FEC, 6 courses), hormone therapy (tamoxifen, 20 mg/day during 3 years), the association of chemotherapy and hormone therapy, or standard follow-up with neither chemotherapy nor hormone therapy. The costs of these strategies were analysed according to the payer's perspective (social security system). In order to complete the economic data, specific investigations were performed at the Centre Oscar-Lambret (COL), a Cancer Center located in Lille (France). The study shows a high cost for chemotherapy (63,767 FF at 5 years) and a high cost for the association (68,891 FF), in comparison to the cost of hormone therapy alone (45,540 FF) or to the follow-up without adjuvant therapy (38,416 FF). These costs could be confronted to the efficacy data of these different strategies and to the cost of avoided relapses. Cost-effectiveness and cost-benefit ratios of these adjuvant strategies could then be assessed. PMID- 9951424 TI - [Quality of death certificates in cases of cancer death in France]. AB - International mortality statistics are based on death certificates on which the causes of death are coded using the World Health Organization's International Classification of Diseases. Most of these statistics are based on the underlying cause of death and do not use the contributory causes of death. We studied the validity of death certificates in a sample of 1,194 French patients known to have died of cancer, comparing the cause of death reported on the death certificate with the cause of death found in the medical record. Death certificates correctly identify cancer as the cause of death in 95% of the cases and with the exact site in 86% of the cases. PMID- 9951425 TI - Pharmacokinetics of the nitric oxide synthase inhibitor L-NG-methylarginine hydrochloride in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group. AB - OBJECTIVES: To characterize the pharmacokinetics of L-NG-methylarginine in patients with septic shock. METHODS: This was an international, uncontrolled, open-label study of L-NG-methylarginine (546C88) therapy given to 32 patients with septic shock. It was conducted in hospital-based intensive care units that admit general surgical and medical patients. Patient cohorts received an infusion of L-NG-methylarginine at fixed dose rates of 1, 2.5, 5, 10, and 20 mg/kg/h for up to 8 hours. The 5 dosing regimens were administered sequentially to separate groups of patients. RESULTS: Of the 32 patients studied, 23 received complete 8 hour infusions. In the other 9 patients, the infusion was terminated prematurely within the first 1/2 to 4 hours. Median clearance of L-NG-methylarginine averaged 485 mL/h/kg for the 1 and 2.5 mg/kg/h dosing cohorts combined but decreased to 283, 181, and 98 mL/h/kg for the 5, 10, and 20 mg/kg/h dosing cohorts, respectively. Median renal clearance was similar at 9 to 26 mL/h for the 1, 2.5, and 5 mg/kg/h dosing cohorts but increased to 156 and 284 mL/h for the 10 and 20 mg/kg/h dosing cohorts, respectively. Median steady-state volume of distribution was similar in all 5 dosing cohorts, averaging 0.66 to 0.82 L/kg. CONCLUSIONS: The 80% decrease in clearance from 485 to 98 mL/h/kg with the increase in dose suggests that a predominant metabolic pathway(s) of L-NG-methylarginine, accounting for at least 80% of clearance, is becoming progressively saturable in association with L-NG-methylarginine infusion rates > or = 5 mg/kg/h. Therefore the use of L-NG-methylarginine infusion rates > or = 5 mg/kg/h are typically expected to result in progressive inhibition of nitric oxide synthase activity. Consequently, patient hemodynamics should be monitored closely to avoid an excessive increase in vasomotor tone, which would be manifest by either an increase in mean arterial pressure or a decrease in cardiac output. The infusion rates of conventional vasopressor(s) (eg, norepinephrine [BAN, noradrenaline]) or L-NG-methylarginine or both may need to be reduced accordingly. PMID- 9951426 TI - Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6). AB - BACKGROUND: The use of pimozide is associated with prolongation of the QT interval and fatal ventricular arrhythmia. We recently reported 2 fatal cases in patients taking pimozide and clarithromycin and we have shown that clarithromycin inhibits CYP3A-mediated metabolism of pimozide in vitro. In this study, we examined the effect of clarithromycin on pimozide pharmacokinetics and QT interval changes in a total of 12 healthy subjects (7 men and 5 women), documented as extensive metabolizers or poor metabolizers of CYP2D6. METHODS: In a randomized, double-blind placebo-controlled crossover design, subjects were given a single 6-mg oral dose of pimozide after 5 days of treatment with clarithromycin (500 mg twice a day) or a placebo pill. Blood samples were obtained before and for 96 hours after pimozide administration, and plasma pimozide and clarithromycin concentrations were measured by HPLC. Electrocardiograms for the analysis of the QTc intervals were recorded immediately before each blood sample. RESULTS: Pimozide significantly lengthened QTc interval in the first 20 hours in both the placebo-treated groups (delta QTcmax = 13.3 +/- 5.3 ms; P = .003) and clarithromycin-treated groups (delta QTcmax = 15.7 +/- 9.5 ms; P = .005) compared with baseline values. This is consistent with an effect of the parent drug. Clarithromycin caused a significant increase in the peak plasma concentration (P = .015), terminal elimination half life (P = .003), and area under the plasma concentration-time curve (P = .024) and a decrease in the clearance (P = .029) of pimozide. Mean QTcmax observed within 20 hours of pimozide administration was significantly greater in the clarithromycin-treated group (23.8 +/- 12.2 ms; P = .0397) than in the placebo treated group (16.8 +/- 6 ms). There was no significant effect of CYP2D6 or gender on the pharmacokinetics or pharmacodynamics of pimozide. CONCLUSIONS: A single 6-mg oral dose of pimozide resulted in measurable QT interval changes. Clarithromycin inhibited CYP3A-mediated pimozide metabolism and the resulting elevation in plasma concentrations may increase the risk of pimozide cardiotoxicity. PMID- 9951427 TI - Pharmacokinetics of cidofovir in renal insufficiency and in continuous ambulatory peritoneal dialysis or high-flux hemodialysis. AB - BACKGROUND: Cidofovir is an antiviral agent used for the treatment of cytomegalovirus infection in patients with acquired immunodeficiency syndrome. Because cidofovir is primarily eliminated by the kidneys and because its main adverse effect is nephrotoxicity, an understanding of the pharmacokinetic disposition of cidofovir in patients with renal insufficiency is necessary. METHODS: Twenty-four subjects were enrolled into this study and were divided into 6 groups depending on their degree of renal dysfunction, including subjects receiving maintenance continuous ambulatory peritoneal dialysis and high-flux hemodialysis. The creatinine clearance (CLCR) for subjects not receiving dialysis ranged from 12 to 164 mL/min. Each subject received a single 0.5 mg/kg intravenous dose of cidofovir over 1 hour. Subjects not receiving dialysis were given intravenous hydration with 1 L normal saline solution and concomitant oral probenecid. Serial serum and urine samples were collected to determine pharmacokinetic parameters with use of noncompartmental methods. RESULTS: Mean +/ SD cidofovir clearance (CL) in control subjects (normal renal function; n = 5) was 1.7 +/- 0.1 mL/min/kg, which decreased with declining renal function as indicated by the regression equation: CL (mL/min/kg) = 0.94 x CLCR (mL/min/kg) + 0.064 (r2 = 0.91). Mean volume of distribution at steady state did not change significantly in subjects with kidney disease and cidofovir serum elimination half-life was significantly increased in subjects with severe renal impairment. Cidofovir was not significantly cleared during continuous ambulatory peritoneal dialysis, but high-flux hemodialysis resulted in the removal of 52% +/- 11% of the dose administered. CONCLUSION: The significant (P < .001) correlation observed between CLCR and CL in subjects with varying degrees of renal insufficiency indicates that aggressive dosage reduction of cidofovir would be necessary in subjects with kidney disease to ensure comparable drug exposure based on serum levels. PMID- 9951428 TI - Systemic and intestinal pharmacokinetics of methotrexate in patients with inflammatory bowel disease. AB - BACKGROUND: The pharmacokinetics of low-dose subcutaneous methotrexate have not been determined throughout the standard weekly dosing interval. It is not known whether methotrexate concentrations in the gastrointestinal tract are sufficient for pharmacologic activity in inflammatory bowel disease. METHODS: Ten patients with inflammatory bowel disease participated in the study. After the patients started taking 15 or 25 mg subcutaneous methotrexate once a week, erythrocyte methotrexate concentration was measured every 2 weeks. The absorption, rectal distribution, metabolism, and elimination of methotrexate were measured. The effect of methotrexate on proliferation of an intestinal epithelial cell line was determined. RESULTS: After weekly subcutaneous administration of methotrexate was begun, trough erythrocyte concentration rose to reach a plateau after 6 to 8 weeks, ranging from 150 to 300 nmol/L. More than 90% of subcutaneously administered methotrexate was rapidly excreted in the urine. The methotrexate plasma time course after subcutaneous administration fit a 2-compartment first order model with biphasic elimination and trough concentration of about 1 nmol/L. Trough and peak methotrexate concentrations (mean value +/- SD) were 64 +/- 33 and 206 +/- 64 fmol/mg in the rectal mucosa and 4 +/- 3 and 51 +/- 26 nmol/L in the rectal lumen. These methotrexate concentrations were in the range found to be pharmacologically active against Caco-2 cell growth, that is, a 50% inhibitory concentration from 10 to 46 nmol/L. CONCLUSION: Subcutaneous methotrexate was well absorbed and distributed to the site of the lesions in patients with inflammatory bowel disease. Methotrexate was concentrated intracellularly in blood and in the rectum. The methotrexate concentration in the rectal mucosa remained within a pharmacologically active range throughout the dosing interval. The findings represent a pharmacologic explanation for the sustained efficacy of weekly methotrexate therapy. PMID- 9951429 TI - Mixed-effects modeling of the pharmacodynamic response to the calcimimetic agent R-568. AB - OBJECTIVE: The parathyroid cell calcium receptor is a novel drug target for affecting parathyroid hormone (PTH) secretion and for treating hyperparathyroidism. R-568 is a calcium receptor agonist that inhibits PTH secretion and increases calcitonin release in preclinical studies. The objective of this study was to evaluate the effect of R-568 on PTH plasma concentrations in humans. METHODS: Eighteen healthy postmenopausal women were included in the study. Single ascending oral doses of 10 to 400 mg were administered in a randomized, placebo-controlled double-blind trial. PTH plasma concentrations were measured for up to 120 hours after each dose. RESULTS: R-568 caused a dose dependent decrease in plasma PTH, with peak effect observed within 1/2 to 2 hours after dosing. The maximum effect did not increase beyond doses from 80 to 160 mg, but duration of response increased at higher doses. An indirect-response model was developed to estimate the rates of input and output of the active moiety(ies), the inhibitory effect on PTH secretion, and the circadian variability in PTH. Population parameter estimates were 3.02 hour-1 and 0.49 hour 1 for rates of input and output of the active moiety(ies), respectively, IA50 (the unscaled amount of R-568 associated with 50% of Emax) was 16.3 mg, Emax (the maximum effect caused by R-568 expressed as a fraction of the rate of PTH secretion in the absence of any drug effect) was 89%, CPTH(baseline) (the baseline PTH plasma concentration in the absence of any drug effect) was 34.6 pg/mL, KePTH (the elimination rate constant for PTH) was 1.73 hour-1, amplitude of the circadian variability in PTH secretion was 5.8%, and the time of peak PTH secretion occurred at about 6 PM. Intersubject variability in parameter estimates ranged from 7% to 121%, and residual variability was 22%. CONCLUSION: The model correctly described the onset, extent, and duration of effect on PTH after a wide range of doses of R-568. PMID- 9951430 TI - Pharmacokinetics of meropenem in critically ill patients with acute renal failure undergoing continuous venovenous hemofiltration. AB - OBJECTIVE: Meropenem is a broad-spectrum antibiotic used for severe infections. In patients with chronic end-stage renal failure, meropenem clearance is reduced and doses must be adjusted according to the creatinine clearance. The aim of this study was to assess pharmacokinetic data of meropenem in patients with acute renal failure and to determine the amount of drug removed by continuous venovenous hemofiltration, an often-used renal replacement therapy in patients with acute renal failure. METHODS: Nine critically ill anuric patients with acute renal failure undergoing continuous venovenous hemofiltration received 500 mg meropenem 2 or 3 times daily. Plasma and hemofiltrate concentrations were determined during 1 dosing interval at steady state. Pharmacokinetic parameters were calculated for a 2-compartment open model and dose requirements were calculated. RESULTS: The total meropenem clearance was 52.0 +/- 8.4 mL/min, with a hemofiltration clearance of 22.0 +/- 4.7 mL/min and a nonrenal nonhemofiltration clearance of 29.9 +/- 5.4 mL/min; 235.9 +/- 88.6 mg, or 47.2% +/- 17.7%, of the dose were removed through continuous venovenous hemofiltration. The terminal elimination half-life was 8.7 +/- 3.5 hours and the volume of distribution at steady state was 12.4 +/- 1.8 L. Peak and trough concentrations for a dosing interval of 12 hours were 38.9 +/- 9.7 mg/L and 7.3 +/- 1.3 mg/L, respectively. The corresponding concentrations for a dosing interval of 8 hours were 44.7 +/- 10.4 mg/L and 11.9 +/- 0.7 mg/L, respectively. CONCLUSION: Pharmacokinetic data of anuric patients with acute renal failure were similar to those of patients with end-stage renal failure. Because hemofiltration contributes significantly to meropenem elimination, the recommended dose for critically ill anuric patients receiving continuous venovenous hemofiltration should be increased by 100% to avoid potential underdosing. PMID- 9951431 TI - Inhibition of angiotensin-converting enzyme in human hand veins. AB - Conversion of angiotensin I to angiotensin II likely occurs in human veins, supporting the existence of endothelial angiotensin-converting enzyme (ACE) activity in these vessels. Using the dorsal hand vein technique, we investigated the effects of 2 ACE inhibitors, captopril (single oral dose of 6.25 mg) and enalaprilat (local infusion of 1 microgram/min), on venous responsiveness in healthy subjects. Orally administered captopril induced a marked decrease in angiotensin I- but not angiotensin II-induced venoconstriction. This blunted response persisted for at least 4 hours. Enalaprilat and captopril increased the sensitivity to bradykinin, decreasing the dose producing half-maximal response (ED50) of bradykinin 18-fold and 5-fold, respectively, without changing the maximal venodilatory response. These results confirm that there is substantial rapid metabolism of angiotensin I in human veins and suggest that a single dose of locally infused angiotensin I can be used with the dorsal hand vein technique to assess the time-course effect of vascular ACE inhibition after oral administration. Our findings also extend previous in vitro observations in human veins by showing that these agents potentiate the venodilatory effects of bradykinin in vivo. PMID- 9951432 TI - Analgesic efficacy of a combination of hydrocodone with ibuprofen in postoperative pain. AB - Two randomized, double-blind, parallel-group single-dose 2 x 2 factorial analgesic studies compared a single-dose or a 2-tablet dose of a combination of 7.5 mg hydrocodone bitartrate with 200 mg ibuprofen with each constituent alone and with a placebo in women with moderate or severe postoperative pain from abdominal or gynecologic surgery. A nurse-observer recorded patient reports of pain intensity and pain relief periodically for 8 hours. In both studies, the combination was significantly superior to placebo for sum of the pain intensity differences (SPID), total pain relief (TOTPAR), peak pain intensity difference (PID) and pain relief, global evaluation, and time to remedication. The combination was likewise significantly superior to both hydrocodone and ibuprofen for most of these summary measures of analgesia. In a factorial analysis, both the hydrocodone and ibuprofen effects were significant for most summary measures of analgesia, whereas results of the interaction contrast were consistent with the concept that the analgesic effect of the combination represents the additive analgesia of its 2 constituents. PMID- 9951433 TI - Ontario joins prenatal HIV-screening movement. PMID- 9951434 TI - Physicians and breast examination. PMID- 9951435 TI - Secondhand smoke and statistical analysis. PMID- 9951436 TI - Smoking out the tobacco connection. PMID- 9951437 TI - Two solitudes. PMID- 9951438 TI - Med students as emotional chameleons. PMID- 9951439 TI - Prevalence of risk factors associated with human papillomavirus infection in women living with HIV. Canadian Women's HIV Study Group. AB - BACKGROUND: Concurrent infection with HIV and human papillomavirus (HPV) in women is associated with increased rates of cervical dysplasia and shorter survival following the development of cervical cancer. The authors examined risk factors for HPV infection at study entry in HIV-positive women enrolled in the Canadian Women's HIV Study, a prospective open cohort study. METHODS: Subjects eligible for this analysis included the 375 HIV-positive women in the Canadian Women's HIV Study for whom HPV test results were available. Questionnaires on behavioural and clinical information, Pap smears, cervicovaginal lavage specimens and vaginal tampon specimens for HPV detection and typing by polymerase chain reaction were obtained at study entry. RESULTS: Overall, 67.2% (252/375) of the women were HPV positive; the global prevalence of intermediate- and high-risk oncogenic HPV types was 49.1% (184/375). Women with squamous cell dysplasia (32/294) were more likely to have HPV infection than those without dysplasia (90.6% v. 62.6%; p = 0.002). Multivariate logistic regression analysis, with adjustment for number of lifetime partners and history of STD, revealed that the following risk factors were independently associated with HPV infection: CD4 count of less than 0.20 x 10(9)/L (adjusted odds ratio [OR] 1.99 [95% confidence interval (Cl) 1.17-3.37 (p = 0.011)]), non-white race (adjusted OR 2.00 [95% Cl 1.17-3.42 (p = 0.011)]), inconsistent condom use in the 6 months before study entry (adjusted OR 2.02 [95% Cl 1.16-3.50 (p = 0.013)]), and lower age, with women age 30-39 years (adjusted OR 0.51 [95% Cl 0.30-0.87 (p = 0.013)]) and age 40 years or older (adjusted OR 0.52 [95% Cl 0.26-1.01 (p = 0.052)]) compared with women less than 30 years of age. INTERPRETATION: Close monitoring for HPV-related effects is warranted in all HIV-positive women, particularly younger, non-white women who do not always use condoms. Counselling for women living with HIV, particularly younger women, should emphasize the importance of regular cytological screening, with increasing frequency as the CD4 count falls. PMID- 9951440 TI - Survey of use of malaria prevention measures by Canadians visiting India. AB - BACKGROUND: Imported malaria is an increasing problem, particularly among new immigrant populations. The objective of this study was to determine the malaria prevention measures used by Canadians originating from a malaria-endemic area when returning to visit their country of origin. METHODS: A 35-item English language questionnaire was administered by interview to travellers at a departure lounge at Pearson International Airport, Toronto, between January and June 1995. Information was collected on subject characteristics, travel itinerary, perceptions about malaria, and pretravel health advice and malaria chemoprophylaxis and barriers to their use. RESULTS: A total of 324 travellers departing on flights to India were approached, of whom 307 (95%) agreed to participate in the study. Participants were Canadian residents of south Asian origin with a mean duration of residence in Canada of 12.8 years. Most of the respondents were returning to visit relatives for a mean visit duration of 6.8 weeks. Although 69% of the respondents thought malaria was a moderate to severe illness and 54% had sought advice before travelling, only 31% intended to use any chemoprophylaxis, and less than 10% were using measures to prevent mosquito bites. Only 7% had been prescribed a recommended drug regimen. Family practitioners were the primary source of information for travellers and were more likely to prescribe an inappropriate chemoprophylactic regimen than were travel clinics or public health centres (76% v. 36%) (p = 0.003). Respondents who had lived in Canada longest and those with a family history of malaria were more likely to use chemoprophylaxis (p < 0.01). INTERPRETATION: Few travellers were using appropriate chemoprophylaxis and mosquito prevention measures. Misconceptions about malaria risk and appropriate prevention measures were the main barriers identified. PMID- 9951441 TI - Trends in the incidence of testicular germ cell cancer in Ontario by histologic subgroup, 1964-1996. AB - BACKGROUND: Testicular cancer is rare but is notable because it affects mainly young men. The incidence of this disease has been increasing in developed countries throughout the world for several decades. The authors examined trends in the incidence of testicular germ cell cancer in Ontario for the period 1964 1996 according to the 2 main histologic groups, seminoma and non-seminoma. METHODS: Data on incident cases of testicular germ cell cancer diagnosed in Ontario residents aged 15-59 years between 1964 and 1996 were extracted from the population-based Ontario Cancer Registry. Annual rates of testicular cancer for the 2 histologic groups were analysed by means of log-linear regression to estimate average annual percent change. RESULTS: Between 1964 and 1996 the incidence of testicular germ cell cancer increased by 59.4%, from 4.01 to 6.39 per 100,000. This corresponded to an average annual increase of about 2% for both nonseminoma and seminoma. The relative increase in incidence was greatest in the lowest age group (15-29 years) for both histologic groups, although the data suggest that the incidence of nonseminoma cancer in this age group began to decline in the early 1990s. The increase in incidence appears to be due to a birth cohort effect, with more recent cohorts of men at increased risk. INTERPRETATION: The rise in the incidence of testicular germ cell cancer, not only in Ontario but also in many developed countries, requires investigation. The search for explanatory factors should focus on exposures whose prevalence may have increased over the past few decades and that are common enough to affect population incidence. The similarity of trends for seminoma and nonseminoma cancer suggests that the underlying risk factors are likely the same. PMID- 9951442 TI - Antileukotrienes, asthma pathogenesis and the pharmaceutical industry. PMID- 9951443 TI - The return of swamp fever: malaria in Canadians. PMID- 9951444 TI - Why is the rate of testicular cancer increasing? PMID- 9951445 TI - Antileukotriene agents in asthma: the dart that kills the elephant? AB - THE PERSISTENCE OF AIRWAY INFLAMMATION is believed to cause the mechanical changes and symptoms of asthma. After decades of research, a new class of medication has emerged that focuses on leukotrienes, mediators of inflammation. These substances are potent inducers of bronchoconstriction, increased vascular permeability and mucus production, and they potentiate the influx of inflammatory cells in the airways of patients with asthma. In this article the author reviews the development, mechanism of action, and clinical and toxic effects of the leukotriene synthesis inhibitors and receptor antagonists that are entering the North American market. These agents can decrease airway response to antigen, airway hyperresponsiveness and exercise-induced asthma. They are also effective inhibitors of ASA-induced symptoms. Although few published studies are available, the antileukotrienes seem almost as effective in the management of chronic asthma as low-dose inhaled corticosteroids, and their use permits a decrease in the frequency of use or dose of corticosteroids. Further evaluation and clinical experience will determine the position of targeted inhibition of the leukotriene pathway in the treatment of asthma. PMID- 9951448 TI - 229 people, 15,000 body parts: pathologists help solve Swissair 111's grisly puzzles. AB - Only 1 of the 229 passengers and crew members killed when Swissair Flight 111 crashed off Nova Scotia in September was visually identifiable. Identifying everyone else on board involved medical and dental detective work of the first order. PMID- 9951446 TI - Prostate cancer: 9. Treatment of advanced disease. AB - A 70-year-old man is referred to a urologist for recommendations on the management of metastatic prostate cancer. His cancer was diagnosed 5 years ago, and he underwent radical prostatectomy at that time. The tumour was confined to the prostate gland (Gleason score 7), and during surgery the lymph nodes were assessed as being clear of cancer. Before the surgery, the patient's prostate specific antigen (PSA) level had been 8 ng/mL. After the prostatectomy, PSA was at first undetectable, but recently the PSA level rose to 2 ng/mL and then, at the most recent test, to 16 ng/mL. A bone scan was ordered to investigate back discomfort, which has been persistent but easily controlled with acetaminophen. Unfortunately, the bone scan shows several sites of metastatic disease. The man's medical history includes type 2 diabetes, which has developed during the past 3 years and which is controlled by diet, as well as asymptomatic hypertension, which is managed by means of a thiazide diuretic. The patient asks what treatments are available, what impact they are likely to have on his disease and what risks are associated with the therapies. PMID- 9951447 TI - Breast cancer online: helping patients navigate the Web. PMID- 9951449 TI - No hospital is an island when it comes to Y2K bug. AB - If a recent meeting on the millennium bug is any indication, Canada's health care facilities have plenty to worry about as the year 2,000 approaches. Topics discussed included the state of readiness within the health care sector and potential legal issues that may arise. PMID- 9951450 TI - [Modulation of osteoblastogenesis: implications for pathophysiology of osteoporosis]. PMID- 9951451 TI - [Congenital cardiovascular malformations and chromosome microdeletions in 22q11.2]. AB - BACKGROUND AND OBJECTIVE: Congenital cardiovascular (c-v) malformations are the leading signs of two syndromes of highly variable phenotypes, the DiGeorge syndrome (DGS) and the velo-cardio-facial syndrome (VCFS), both of which in the majority of cases are caused by microdeletion in the chromosome region 22q11.2. It was the aim of this study to ascertain the frequency of these chromosomal abnormalities in patients with unselected congenital cardiovascular malformation, and to assess the type of c-v malformation for which microdeletion analysis of the mentioned region would be indicated. PATIENTS AND METHODS: The cohort consisted of 90 patients with congenital c-v malformations (35 males, 55 females; mean age 3.6 years (19th week of pregnancy-36 years). Most of them were newborns. The c-v anomalies were: ventricular septal defect (n = 20), pulmonary atresia (10), Fallot's tetralogy (9), truncus arteriosus communis (6), aortic valve stenosis (6), atrioventricular canal (6), type B interrupted aortic arch (5), atrial septal defect (5), tricuspid atresia (4), hypoplastic left heart syndrome (4), persisting ductus arteriosus (3), pulmonary valve stenosis (3), complete (third degree) atrioventricular block (2), Ebstein's anomaly (1), tachycardia (1) and enlarged right atrium (1). Four of 14 fetuses included in this study had complex cardiac anomalies that could not be definitively classified. Cytogenetic karyotype analysis was unremarkable in all cases. Microdeletion detection was done by fluorescence-in-situ-hybridization (FISH). RESULTS: 14 of the 90 cases (about 16%) showed microdeletion in the examined chromosomal region 22q11.2. Among the group with microdeletion were aortic arch interruption (5/5), ventricular septal defect (2/20). Fallot's tetralogy (1/9) and atrial septal defect (1/5). All the deletion carriers had other signs of the DGS/VCFS complex. One parent each in two of the microdeletion patients had the same microdeletions. CONCLUSION: In patients with congenital c-v and associated malformations of dysmorphism microdeletion diagnosis of 22q11.2 by FISH is indicated in addition to conventional cytogenetic testing. The incidence of this microdeletion seems to be especially high among patients with type B interrupted aortic arch. PMID- 9951452 TI - [Shy-Drager syndrome: a rare cause of orthostatic hypotension]. AB - HISTORY AND ADMISSION FINDINGS: A 71-year-old man was admitted because of treatment-resistant orthostatic hypotension of unknown aetiology. When aged 64 years he developed some impotence and later urinary incontinence and urinary frequency. At 68 years he noted vertigo on physical activity, and a year later he had signs of reversible cerebral ischaemia. At this point the Schellong test demonstrated vasovagal circulatory dysfunction. After his 70th birthday the unsteadiness on walking and standing got worse and he had recurrent syncopes. He was in a wheel-chair when hospitalized and even the unsteady walk he could maintain for only a few seconds. INVESTIGATIONS: Plasma and urinary concentrations of catecholamines were at the lower limit of normal but failed to increase during orthostasis. Hormonal, cardiological and infectious causes of the orthostatic hypotension were excluded. Orthostatic tests after Schellong and with the tilting table showed orthostatic hypotension without increased sympathetic activity but hypertensive blood pressure levels during the recumbent period. Intravenous infusion of norepinephrine produced an excess rise in blood pressure (raised norepinephrine sensitivity). The recurrent urinary infection was shown to be due to a hypotonic bladder detrusor muscle. Neurological examination revealed cerebellar dysfunction, signs of pyramidal tract abnormality and sensory polyneuropathy. A Shy-Drager syndrome was diagnosed on the basis of the history, absent blood pressure rise and lack of catecholamine release during orthostasis with increased epinephrine sensitivity and characteristic neurological signs. TREATMENT AND COURSE: Physiotherapy and elastic stockings with administration of mineralocorticoids as well as of one direct (norfenefrine) and one indirect (amezinium) sympathomimetic drug failed to improve adequately the abnormal orthostatic response. But on additional administration of an alpha 2-receptor antagonist (yohimbine) the patient was able to stand and walk for a few minutes, but the urinary incontinence and the other neurological signs remained treatment resistant. CONCLUSION: If orthostatic hypotension occurs together with neurological symptoms, a Shy-Drager syndrome should be taken into account. PMID- 9951453 TI - [Angioleiomyoma of the gallbladder: a rare cause of hemobilia in a patient on dialysis]. AB - HISTORY AND FINDINGS: Acute colicky upper abdominal pain occurred in a 47-year old man on renal dialysis who also had chronic recurrent pancreatitis. On physical examination he was noted to be slightly jaundiced and he had slight pain when the liver edge was palpated. A few days later melaena developed and the haemoglobin concentration fell from normal levels to 6.9 g/dl. INVESTIGATIONS: Serology gave no evidence of acute pancreatitis, but biochemical tests indicated cholestasis. Ultrasonography revealed widening of the intra- and extrahepatic biliary tract. Endoscopic retrograde cholecystopancreatography demonstrated bleeding from the biliary tract (haemobilia) as the source of the bleeding. Selective angiography of the coeliac trunk showed extravasation in the region of the gallbladder. TREATMENT AND COURSE: As a vascular anomaly in the gallbladder was suspected, a cholecystectomy was performed. The surgical specimen revealed an angioleiomyoma of the gallbladder. The postoperative course was without complications and there was no further haemobilia. CONCLUSIONS: Haemobilia is a relatively rare cause of upper gastrointestinal bleeding. It is usually due to trauma (accidental or iatrogenic) to the liver or the biliary tract. Rarely, as in this case, it can be caused by a benign mesenchymal neoplasm. Clotting disorder in uraemia or intermittent heparin administration for dialysis may in this patient have contributed to the bleeding. PMID- 9951454 TI - [Raloxifene]. PMID- 9951455 TI - [New noninvasive procedure of diagnosing bile leaks: spiral CT cholangiography]. PMID- 9951456 TI - [Diagnosis and therapy of congenital myasthenia syndrome]. PMID- 9951457 TI - [The right of the management committee to participate in decisions concerning the distribution of coworker physicians' funds. Decision of the Federal Labor Court on 16 June 1998]. PMID- 9951459 TI - [HIV, hepatitis, influenza: new antiviral agents]. PMID- 9951458 TI - [Successful lysis therapy of inferior vena cava and iliofemoral venous thrombosis in heparin-induced thrombocytopenia type II]. PMID- 9951460 TI - Linear nevus sebaceous syndrome. PMID- 9951461 TI - Cosmetic surgery. PMID- 9951462 TI - Intraoperative mitomycin C for pterygium surgery. PMID- 9951463 TI - Physical standards and military service. PMID- 9951464 TI - Vitreous change in retinitis pigmentosa. PMID- 9951465 TI - Conjunctival flaps or phototherapeutic keratectomy? PMID- 9951466 TI - Malignant nonteratoid medulloepithelioma. PMID- 9951467 TI - Can ethical guidelines save our professionalism? PMID- 9951468 TI - Associations of antioxidant enzymes with cataract and age-related macular degeneration. The POLA Study. Pathologies Oculaires Liees a l'Age. AB - OBJECTIVE: Oxidative mechanisms may play an important role in the etiology of cataract and age-related macular degeneration (AMD). The authors present the level of two antioxidant enzymes in relation to cataract and AMD. DESIGN: Population-based, cross-sectional study on cataract and AMD and their risk factors. PARTICIPANTS: This study includes 2584 participants recruited among the residents of the town of Sete (in the south of France), who were 60 years of age or older. INTERVENTION/METHODS: Cataract was defined on the basis of slit-lamp examination, according to the Lens Opacities Classification System III, and AMD on the basis of fundus photographs according to an international classification. Biologic measurements were made centrally from blood samples for which the patient fasted. MAIN OUTCOME MEASURES: The presence of early and late AMD and of subcapsular, cortical, nuclear, and mixed cataracts was assessed and related to the levels of plasma glutathione peroxidase and erythrocyte superoxide dismutase. RESULTS: After multivariate adjustment, higher levels of plasma glutathione peroxidase (pIGPx) were significantly associated with a ninefold increase in late AMD prevalence, a sixfold increase in cortical cataract, and a twofold increase in nuclear and mixed cataracts. High levels of erythrocyte superoxide dismutase (SOD) activity were not associated with late AMD and early signs of AMD but were associated with a twofold increase in nuclear cataract. CONCLUSION: The authors show here, for the first time, a strong association of high levels of pIGPx with age-related eye diseases. High levels of SOD also are associated with increased risk of nuclear cataract. More data are needed at the biochemical and epidemiologic levels for a better understanding of these findings. PMID- 9951469 TI - Randomized clinical trial of a new dexamethasone delivery system (Surodex) for treatment of post-cataract surgery inflammation. AB - OBJECTIVE: To evaluate the safety of Surodex Drug Delivery System (Oculex Pharmaceuticals, Inc., Sunnyvale, CA) containing dexamethasone 60 micrograms, for use in cataract surgery, and to compare its anti-inflammatory efficacy with conventional dexamethasone 0.1% eyedrops. DESIGN: Randomized, masked, and partially controlled trial. PARTICIPANTS: Sixty eyes of 60 Asian patients undergoing extracapsular cataract extraction with intraocular lens implantation were examined. Of these, 28 eyes of 28 patients served as control eyes. Patients were stratified for age and presence of diabetes mellitus. INTERVENTION: Surodex was inserted in the anterior chamber of 32 eyes at the conclusion of surgery. These eyes received placebo eyedrops four times a day after surgery for 4 weeks. Control eyes received neither Surodex nor a placebo implant but were prescribed conventional 0.1% dexamethasone eyedrops four times a day for 4 weeks. MAIN OUTCOME MEASURES: Anterior chamber cells and flare were clinically graded at the slit lamp. Anterior chamber flare was objectively assessed with the Kowa FM500 Laser Flare Meter (Kowa Co. Ltd, Tokyo, Japan) for up to 3 months after surgery. Intraocular pressure and corneal endothelial specular microscopy with morphometric cell analysis were performed for up to 1 year after surgery. RESULTS: Clinical slit-lamp assessment of anterior chamber flare and cells showed no difference between Surodex-treated eyes and dexamethasone eyedrop-treated eyes. Flare meter readings showed lower flare levels in the Surodex group at all postoperative visits compared with the dexamethasone eyedrop group. Flare reduction in the Surodex group reached statistical significance at days 4, 8, 15, and 30 after surgery. At 3 months, flare was reduced to preoperative levels in the Surodex group but was still raised in the dexamethasone eyedrop group. Five eyes in the dexamethasone eyedrop group required augmentation of steroids and were deemed therapeutic failures as opposed to one eye in the Surodex group. One patient in the dexamethasone eyedrop group developed postoperative open-angle glaucoma with profound visual field loss and optic disc cupping, resulting in hand movements vision. No significant difference in endothelial cell loss was noted between Surodex-inserted eyes and dexamethasone eyedrop-treated eyes for up to 1 year after surgery. CONCLUSIONS: Intraocular placement of a single Surodex is a safe and effective treatment method to reduce intraocular inflammation after cataract surgery. There was no statistical difference in efficacy between Surodex and 0.1% dexamethasone eyedrops in reducing intraocular inflammation, as measured by clinical methods, while Surodex was clearly superior to eyedrops in reducing aqueous flare as objectively assessed with the laser flare meter. PMID- 9951470 TI - Influence of cataract surgery on progression of lens opacities in the fellow eye. AB - OBJECTIVE: To evaluate whether, in the Italian-American natural history study, cataract surgery in one eye influences the incidence/progression rate of lens opacities in the fellow eye. DESIGN: Follow-up study of age-related cataract. PARTICIPANTS: A total of 1399 participants with age-related cataracts were regularly followed for 5 years and cataract status evaluated by the Lens Opacities Classification System II on slit-lamp and retroillumination lens photographs. A total of 228 participants had cataract surgery in 1 eye during the study period, and 192 had sufficient follow-up visits to be included in the analysis. MAIN OUTCOME MEASURE: The incidence/progression of cataract was defined as two or more consecutive visits with a severity grade greater than the baseline grade. RESULTS: When entered into a Cox model, incidence/progression of specific cataract types was not associated with cataract surgery on the fellow eye and was not significantly different from that observed in participants who had no cataract surgery. CONCLUSIONS: Cataract extraction does not influence incidence/progression rate of specific lens opacities in the fellow eye. PMID- 9951471 TI - Suprachoroidal hemorrhage during pars plana vitrectomy. Risk factors and outcomes. AB - OBJECTIVE: Suprachoroidal hemorrhage (SCH) is an uncommon but serious complication of pars plana vitrectomy (PPV) that can be associated with a guarded visual prognosis. The purpose of this study is to document the risk factors and outcomes of this complication. DESIGN: Case-control study of consecutive cases of intraoperative SCH occurring during PPV (n = 36) and controls of PPV uncomplicated by SCH (n = 116). MAIN OUTCOME MEASURES: Baseline systemic and ocular characteristics, intraoperative findings, surgical procedures, and final anatomic and visual outcomes were measured. RESULTS: Significant risk factors for the development of SCH during PPV included high myopia (22% of cases vs. 5% of controls), history of retinal detachment (RD) surgery (61% vs. 22%), rhegmatogenous RD (97% vs. 60%), use of cryotherapy (75% vs. 33%), scleral buckling at the time of PPV (50% vs. 19%), external drainage of the subretinal fluid (22% vs. 2%), and intraoperative systemic hypertension. In the 34 SCH cases with 3 months' or more follow-up, the final visual acuity was 20/200 or greater in 11 (32%), count fingers in 5 (15%), hand movement in 7 (21%), light perception in 7 (21%), and no light perception in 4 (12%). In the 106 controls with 3 months' or more follow-up, the final visual acuity was 20/200 or greater in 79 (75%), count fingers in 20 (19%), hand movement in 5 (5%), light perception in 1 (1%), and no light perception in 1 (1%). In the eyes with SCH, 17 (50%) had persistent RD, 10 (33%) had secondary glaucoma develop, and 8 (24%) became hypotonic. The visual and anatomic outcomes of the SCH cases were significantly worse than those in the control group (P < 0.001). The visual outcome was more favorable if the SCH did not extend into the posterior pole (P = 0.002). Attempted intraoperative drainage of SCH was not associated with a better outcome. CONCLUSION: Risk factors for the development of intraoperative SCH during PPV are high myopia, previous RD surgery, rhegmatogenous RD, cryotherapy, scleral buckling, external drainage of subretinal fluid, and intraoperative systemic hypertension. Anatomic and visual outcomes are significantly worsened after this complication. PMID- 9951472 TI - The effect of the surgeon and the laser wavelength on the response to focal photocoagulation for diabetic macular edema. AB - OBJECTIVE: To determine the effect of the surgeon and the wavelength of laser used on the response to focal photocoagulation for diabetic macular edema. DESIGN: Retrospective case-control study. PARTICIPANTS: Forty-four matched pairs of cases by two different retina surgeons in the study of surgeon influence were examined. Sixty-nine matched pairs of cases using dye yellow versus argon green laser treatment in the study of wavelength influence also were studied. In both studies, eyes were matched for the only patient-dependent variables affecting outcome: age, initial visual acuity, follow-up time, and diabetic control by diet versus any other method. INTERVENTION: Focal laser photocoagulation for clinically significant diabetic macular edema was performed. MAIN OUTCOME MEASURE: Visual acuity at 6 months follow-up was measured. RESULTS: For the study in which the only difference was the surgeon, at 6 months follow-up the mean difference in logarithm of the minimum angle of resolution (logMAR) visual acuity was -0.045, 95% confidence interval (-0.160, 0.070). For the study in which wavelength varied, at 6 months the mean difference in logMAR visual acuity was 0.048, 95% confidence interval (-0.147, 0.052). The power of the surgeon study to detect a difference in the logMAR visual acuity of 0.3 is 88% and of the wavelength study to detect this difference is 99%. CONCLUSION: In looking at the 6-month visual outcome after focal laser photocoagulation for clinically significant diabetic macular edema, different fellowship trained surgeons and the choice of green or yellow wavelength had no effect on the treatment outcome. PMID- 9951473 TI - New surgical approach for removing massive foveal hard exudates in diabetic macular edema. AB - OBJECTIVE: To examine the efficacy of surgical removal of foveal hard exudates in diabetic macular edema and to determine the expression of vascular endothelial growth factor (VEGF) in the excised specimens. DESIGN: Cohort study. PARTICIPANTS: Seven eyes of six patients with massive subfoveal hard exudate due to diabetic macular edema were examined. The average age of the patient was 56 years (range, 46-60 years). INTERVENTION: Pars plana vitrectomy for removal of massive foveal exudates was performed. MAIN OUTCOME MEASURES: Preoperative and postoperative visual acuity and complications were recorded; immunohistochemical staining for VEGF and other cell markers for macrophage and pigment epithelial cells in excised specimens was performed. RESULTS: Postoperative best-corrected visual acuity improved by two or more lines of Snellen equivalent in five eyes (71%) (P = 0.0061). VEGF, identified by anticytokeratin and CD68 antibodies, was expressed in pigment epithelial cells and macrophages invading the hard exudates. CONCLUSION: Surgical removal of foveal hard exudates might be effective in low vision patients with diabetic maculopathy. VEGF might play a role in the formation and persistence of foveal hard exudates in diabetic macular edema. PMID- 9951474 TI - Yearly rates of rod and cone functional loss in retinitis pigmentosa and cone-rod dystrophy. AB - OBJECTIVE: To provide the first measures of the relative rates of rod and cone functional loss in patients with retinitis pigmentosa (RP) or cone-rod dystrophy (CRD). DESIGN: Five-year, prospective natural history study. PARTICIPANTS: Ninety six patients (67 with RP and 29 with CRD) retaining measurable rod-mediated visual function and 5 normal subjects were tested at baseline and annually for 4 consecutive years. MAIN OUTCOME MEASURES: Tests of visual function included visual acuity, dark-adaptation thresholds, dark-adapted static perimetry, and rod and cone computer-averaged electroretinograms (ERGs), which were obtained over a range of retinal illuminances. Intervisit variability for each measure was obtained in a subset of patients who were tested twice within a 2-month interval and was used to determine whether an individual patient had shown progression, regression, or no change over a particular study interval. RESULTS: Over a 4-year interval, a significant number of patients with RP (60%) and CRD (62%) showed a decline in cone ERG amplitude. For rod ERG amplitude, the percentage of patients with RP or CRD showing progression was 64% and 45%, respectively. Although visual acuity, dark-adapted threshold, and rod visual field area also declined significantly over the 4-year period, the mean rate of change and the numbers of patients showing progression on these measures were lower than those for ERG measures. On specialized ERG testing, the yearly change in rod ERG threshold in RP was greater than the yearly change in cone ERG threshold, and the rate of progression varied significantly among inheritance types. For patients with CRD, the yearly change in rod threshold was comparable to the yearly change in cone ERG threshold. CONCLUSIONS: This study helps to define the natural progression of rod-mediated and cone-mediated functional loss in patients with RP and CRD. PMID- 9951475 TI - Noninvasive mapping of the normal retinal thickness at the posterior pole. AB - OBJECTIVE: Objective and sensitive measurements of the retinal thickness at the posterior pole are useful to detect and delineate macular edema or retinal atrophy. The authors therefore developed an instrument, the Retinal Thickness Analyzer (RTA), to map the retinal thickness rapidly. The RTA was used to study the normal thickness at the posterior pole and to provide a pilot baseline. DESIGN: Cross-sectional study. METHODS: A green (540-nm) laser slit was focused on the retina via a scanning mirror placed at the conjugate plane of the pupil. The intersection between the laser slit and the retina was viewed at an angle and recorded by a video camera. Nine scans, each acquired in 200 to 400 msec, covered the central 20 degrees of the fundus. PARTICIPANTS: The posterior pole was mapped in 29 normal subjects 19 to 76 years of age (mean, 48 years). RESULTS: The thickness maps matched the posterior pole anatomy. Points with maximum thickness were located in the perifovea in a C-shaped manner extending from the disc to above and below the fovea. The local variation (standard deviation) in retinal thickness among the subjects was, on average, 15 microns. Age, gender, and race did not have a large effect (< 35 microns) on the values. CONCLUSIONS: Rapid scanning thickness analysis with the RTA provides a detailed map of the retinal thickness. The relatively narrow range of thickness values in normal subjects indicates that the method may provide a sensitive detection of pathologic thickening or thinning of the retina. PMID- 9951476 TI - The use of confocal scanning laser tomography in the evaluation of retinal elevation in age-related macular degeneration. AB - OBJECTIVE: To evaluate the feasibility of using confocal scanning laser tomography in the analysis of macular topography in patients with subfoveal choroidal neovascularization associated with age-related macular degeneration (AMD) and to analyze quantitatively the changes in topography after local strontium-plaque radiation therapy. DESIGN: Prospective case series. PARTICIPANTS: A total of 16 eyes with subfoveal choroidal neovascular membranes (CNVM) treated with strontium-90 (90Sr)-plaque radiation therapy and 16 fellow eyes of 16 patients were examined. INTERVENTION: Confocal scanning laser analysis of macular surface topography before and after irradiation of the macula was performed. MAIN OUTCOME MEASURES: Parameters describing the height and volume of the retinal elevation in the macula were measured. RESULTS: The maximum height of the macular lesion at baseline was 0.25 mm (standard deviation [SD], 0.12 mm) in eyes showing regression of the CNVM during follow-up and 0.34 mm (SD, 0.19 mm) in eyes showing continued growth of the CNVM. During follow-up, a mean decrease in the maximum height of the macular lesion ranging from 0.03 to 0.10 mm occurred in eyes with regression of the CNVM, whereas the mean maximum height increased by 0.07 to 0.15 mm during follow-up visits in eyes with continued growth of the CNVM. All parameters describing the mean height and volume of the lesion also decreased significantly in patients showing angiographic regression, whereas they increased or remained unchanged in patients with continuous growth of the CNVM despite irradiation. The corresponding parameters also were higher in fellow eyes with untreated CNVM than in eyes without exudative AMD. CONCLUSIONS: Confocal scanning laser tomography can be used to monitor the amount of the change in neurosensory detachment in AMD. The parameters obtained by confocal scanning laser tomography correlate with CNVM perfusion after 90Sr-plaque radiation therapy. This technology is a useful tool for objective evaluation of morphologic change after institution of new therapeutic methods for the treatment of AMD. PMID- 9951477 TI - Surgical results of persistent hyperplastic primary vitreous. AB - PURPOSE: To evaluate the surgical success of patients with persistent hyperplastic primary vitreous (PHPV) and to identify preoperative indicators of visual outcome. DESIGN: Noncomparative case series. METHODS: The diagnosis of PHPV was made in 35 eyes of 27 patients from 1982 to 1994. In each case, anterior and/or posterior PHPV findings, preoperative testing, surgical procedures, and visual outcomes were documented. Twenty-nine of 35 eyes were managed surgically. Follow-up ranged from 2 months to 12 years. RESULTS: Of the 35 eyes, 2 (5.7%) had strictly anterior PHPV, 8 (22.9%) had strictly posterior PHPV, and 25 (71.4%) had components of both anterior and posterior disease. Initial lensectomy and vitrectomy was performed in 24 eyes (68.6%). Surgery was withheld in four eyes secondary to severity of disease with an unrecordable visual-evoked potential (VEP). Reoperation rate was 32.3% for membrane reproliferation, glaucoma, vitreous hemorrhage, retinal detachment, or strabismus. Best-corrected final visual acuity ranged from 20/60 to no light perception. Six eyes (17%) maintained Snellen visual acuity despite posterior PHPV with some degree of retinal dysplasia. CONCLUSIONS: Surgical treatment of PHPV can result in functional visual outcome despite posterior segment involvement. The degree of ocular malformation, however, will ultimately limit the amount of visual improvement. Preoperative testing, including VEP, may aid in determining surgical candidates. PMID- 9951478 TI - Indocyanine green angiographic features in ocular sarcoidosis. AB - OBJECTIVE: To determine indocyanine green (ICG) angiographic features and evaluate the extent of choroidal involvement in proven cases of posterior ocular sarcoidosis. DESIGN: Nonrandomized controlled trial. PARTICIPANTS: Nineteen patients (14 females, 5 males; average age, 56 +/- 4 years) with clinically typical posterior sarcoidosis (biopsy-proven in 6 cases and fulfilling the other diagnostic criteria in 13 cases) participated, with 10 control subjects (average age, 48 +/- 7 years). Criteria for the diagnosis of sarcoidosis were a positive biopsy result or the presence of at least three of the following four criteria: elevated serum angiotensin-converting enzyme, elevated lysozyme, cutaneous anergy, and hilar lymph node enlargement. INTERVENTION: Indocyanine green angiography was performed according to a standard angiographic protocol used in inflammatory disorders. MAIN OUTCOME MEASURES: Indocyanine green angiographic features and proportion of choroidal inflammatory involvement were measured. RESULTS: Indocyanine green angiographic features could be classified into four main patterns. The first pattern is hypofluorescent choroidal lesions in the early and intermediate phases, irregularly distributed, invisible on funduscopy or fluorescein angiography, and localized in the midperiphery (63% of patients), in the macula (11%) or in both regions (26%) with an average dot diameter of 0.31 +/- 0.03 disc diameters. These lesions either became isofluorescent in the late phase of the angiogram (Type 1, present in all patients) or remained hypofluorescent (Type 2, present in 84% of patients). The second pattern is focal hyperfluorescent pinpoints visible in the intermediate and late phases (in 89% of patients). The third pattern is fuzzy choroidal vessels with leakage in the intermediate phase of the angiogram, and the fourth pattern is diffuse late zonal choroidal hyperfluorescence with staining in the late phase of the angiogram, both features being present in all patients. CONCLUSIONS: Indocyanine green angiography allowed the authors to assess and quantify the hitherto unknown extent of choroidal involvement in ocular sarcoidosis. Furthermore, characteristic ICG findings might represent an additional valuable tool for diagnosing and monitoring this disease. PMID- 9951479 TI - Choroidal tuberculosis diagnosed by polymerase chain reaction. A clinicopathologic case report. AB - PURPOSE: To show the use of the polymerase chain reaction (PCR) in a granulomatous choroidal lesion to support a diagnosis of tuberculosis. DESIGN: Observational case report. TESTING: Nucleic acid target amplification of a choroidal specimen using PCR for detection of Mycobacterium tuberculosis was tested. MAIN OUTCOME MEASURES: Positive nucleic acid target amplification for M. tuberculosis in the ocular sample was measured. RESULTS: PCR was positive for M. tuberculosis with appropriate negative controls. CONCLUSIONS: PCR was thought to be a useful supportive technique in the diagnosis of choroidal tuberculosis. PMID- 9951480 TI - Choroidal abnormalities in Behcet disease observed by simultaneous indocyanine green and fluorescein angiography with scanning laser ophthalmoscopy. AB - OBJECTIVE: To examine choroidopathy in patients with Behcet disease. DESIGN: Prospective clinical study. PARTICIPANTS: Thirty-three patients (63 eyes) with Behcet disease. INTERVENTION: Patients underwent simultaneous indocyanine green (ICG) and fluorescein angiography with a double detector of scanning laser ophthalmoscopy. MAIN OUTCOME MEASURES: Angiographic findings recorded on videotapes were evaluated. The relation of angiographic findings with systemic activity and aqueous inflammation was also analyzed. RESULTS: Fluorescein angiography showed leakage in varying degrees from retinal vessels in 30 patients (53 eyes, 84%). The ICG angiographic findings were choroidal vascular wall staining in 16 eyes (25%), hyperfluorescent spots in 42 eyes (66%) and hypofluorescent plaques in 22 eyes (35%), both of which were not evident with fluorescein, leakage from choroidal vessels in 3 eyes (5%), and irregular filling of choriocapillaris in 11 eyes (17%). These findings did not have a statistically significant correlation with the presence or absence of aqueous inflammation or oral aphthous ulcerations. CONCLUSIONS: The patients with Behcet disease showed choroidal abnormalities, which could be revealed only by ICG angiography, but not with funduscopy or fluorescein angiography. Simultaneous ICG and fluorescein angiography would be useful for examining choroidal lesions in Behcet disease. PMID- 9951481 TI - Ultrasound biomicroscopy as a tool for detecting and localizing occult foreign bodies after ocular trauma. AB - OBJECTIVE: To show the utility of ultrasound biomicroscopy (UBM) in imaging small ocular foreign bodies of the anterior segment. DESIGN: Retrospective case series. PARTICIPANTS: Twelve eyes of 12 consecutive patients evaluated in the emergency department or referred to specialty services at 1 institution between August 1994 and November 1997 were examined. INTERVENTION: Ocular ultrasound biomicroscopy was performed. MAIN OUTCOME MEASURES: Detection and localization of an ocular foreign body were measured. RESULTS: An intraocular or superficial foreign body was detected by UBM in 9 (75%) of 12 eyes. The foreign body was classified as corneal in two eyes, subconjunctival in two, intrascleral in three, and intraocular in two eyes. The foreign body was not visible by ophthalmic physical examination in seven of the nine eyes with a confirmed ocular foreign body. In the remaining two eyes, UBM was used to determine the depth of a visible foreign body. In three of the eyes with a confirmed foreign body, computed tomography and/or contact B-scan ultrasonography was obtained and failed to show a foreign body. Six of the foreign bodies were nonmetallic. CONCLUSIONS: Clinical detection of ocular foreign bodies after trauma can be hindered by small size, haziness of the optical media, poor patient cooperation, or hidden location. Ultrasound biomicroscopy is a valuable adjunct in the evaluation of suspected ocular foreign bodies, especially in cases involving small, nonmetallic objects. PMID- 9951482 TI - The effects of carotid endarterectomy on the retrobulbar circulation of patients with severe occlusive carotid artery disease. An investigation by color Doppler imaging. AB - OBJECTIVE: To analyze the effects of carotid endarterectomy on the retrobulbar circulation of patients with severe occlusive carotid artery disease (OCAD) by means of color Doppler imaging (CDI). DESIGN: Prospective. PARTICIPANTS: A total of 17 consecutive patients with severe OCAD and neurologic symptoms (with a history of transitory ischemic attack or cerebral vascular accident) participated. INTERVENTION: All 17 patients underwent carotid endarterectomy. The CDI of both orbits was performed by one masked investigator before surgery and at 1 week and 1 month after surgery. MAIN OUTCOME MEASURES: Peak systolic velocity, end diastolic velocity, and resistive index of the ophthalmic, central retinal, and temporal short posterior ciliary arteries were measured. The authors compared the hemodynamic parameters at all intervals. RESULTS: Peak systolic and end diastolic velocities in the ophthalmic, central retinal, and temporal short posterior ciliary arteries increased significantly 1 week and 1 month after carotid endarterectomy (P < 0.05). After surgery, the resistive indices in the central retinal and temporal short posterior ciliary arteries decreased significantly at both intervals (P < 0.05). The six patients who had reversed ophthalmic artery flow before surgery showed forward ophthalmic artery flow after carotid endarterectomy. The contralateral orbits showed no significant hemodynamic change after endarterectomy (P < 0.05). CONCLUSIONS: Hemodynamic changes in patients with severe OCAD undergoing carotid endarterectomy suggest improvement in the ipsilateral retrobulbar blood flow. PMID- 9951483 TI - Optociliary veins in optic nerve sheath meningioma. Indocyanine green videoangiography findings. AB - OBJECTIVE: To report the indocyanine green videoangiography (ICG-V) characteristics of optociliary veins (OV) in optic nerve sheath meningioma (ONSM). DESIGN: Case series. PARTICIPANTS: Four eyes (patients) with OV and ONSM were examined. INTERVENTION: Indocyanine green videoangiography and intravenous fluorescein angiography (IVFA) were prospectively performed. MAIN OUTCOME MEASURES: The course of OV in ONSM cases was observed with ICG-V and IVFA. RESULTS: On ICG-V, the course of OV was followed from their origin at small tributaries of the central retinal vein, their junction with choroidal veins, and finally to their drainage in the vortex venous system. The authors found an inverse relationship between the degree of optic disc edema and the development and ease of visualization of the optociliary veins and their draining course through the choroidal circulation. The mean time from the injection of indocyanine green to the visualization of OV's draining choroidal vessels was 35.4 seconds (range, 25.4-50 seconds). Intravenous fluorescein angiography allowed visualization of OV only at the margins of the optic disc in all cases. CONCLUSION: Indocyanine green videoangiography provides important and new information in cases with OV and ONSM that is not obtained with IVFA. Such information may provide important knowledge regarding the hemodynamics of the choroidal circulation in normal and pathologic states. PMID- 9951484 TI - Agreement and repeatability of infrared pupillometry and the comparison method. AB - OBJECTIVE: To evaluate the accuracy and repeatability of the widely used comparison method of measuring pupil size. DESIGN: Cross-sectional study. PARTICIPANTS: Fourteen eyes of seven healthy myopic subjects were examined. INTERVENTION: Two examiners made two repeated measures of pupil diameters of 14 eyes using Rosenbaum card comparison pupillometry and infrared pupillometry. Subjects fixated on a distant visual acuity chart, and pupils were measured under three luminance conditions. The agreement and inter-rater repeatability of both methods were determined. MAIN OUTCOME MEASURES: Outcomes were pupil diameters, limits of agreement, and coefficient of repeatability of two examiners. RESULTS: The mean difference between the two techniques ranged from 0.3 to 0.5 mm. The limits of agreement within two standard deviations ranged from 2.4 to 2.8 mm. Coefficient of repeatability ranged from 0.6 to 1.4 mm for infrared pupillometry and 1.0 to 1.2 mm for Rosenbaum pupillometry. Inter-rater repeatability of Rosenbaum pupillometry was consistently pupil diameter biased. Pupil diameters measured with the Rosenbaum method were consistently larger than diameters measured with the infrared technique for both examiners under all luminance conditions. CONCLUSIONS: Results indicate that although the mean difference in techniques was small, the range of the agreement between the Rosenbaum and the infrared techniques was large. The Rosenbaum method consistently overestimated pupil diameters and was subject to inter-rater repeatability bias. Rosenbaum pupillometry may not be appropriate when accurate pupil measurements are required. The results have implications for many clinical trials in ophthalmology, including those evaluating refractive surgery that use Rosenbaum comparison pupillometry. PMID- 9951485 TI - Early strabismus surgery for thyroid ophthalmopathy. AB - OBJECTIVE: To determine whether strabismus surgery during active thyroid ophthalmopathy is beneficial for selected patients. DESIGN: Case series. PARTICIPANTS: Eight patients with severe restrictive strabismus due to thyroid ophthalmopathy underwent early strabismus surgery and were followed for a minimum of 16 months after their initial surgery. INTERVENTION: All eight patients underwent strabismus surgery while their thyroid ophthalmopathy was evolving. MAIN OUTCOME MEASURES: Success was determined by the ability to fuse in the primary position at distance and near without an abnormal head position, and the absence of vision-threatening complications related to strabismus surgery. RESULTS: All eight patients achieved successful long-term alignment. Four patients (50%) required more than one operation. CONCLUSIONS: Strabismus surgery during active thyroid ophthalmopathy can result in long-term stable alignment and may be a useful alternative in selected patients with marked disability due to thyroid ophthalmopathy. PMID- 9951486 TI - Ocular abnormalities in Alagille syndrome. AB - OBJECTIVE: To assess the type and frequency of ocular abnormalities occurring in Alagille syndrome (AS) in a large group of affected patients and their parents and the potential pathogenetic role of fat-soluble vitamin deficiency. DESIGN: Observational case series. PARTICIPANTS: Twenty-two children with AS and 23 of their parents participated. MAIN OUTCOME MEASURES: Participants underwent full ophthalmic examination, including refraction, orthoptic examination, keratometry, slit-lamp examination, and funduscopy. Corneal diameter measurement was performed in a subset of nine and fluorescein angiography in a subset of six. Serum levels of vitamins A and E and cholesterol were measured. RESULTS: The most common ocular abnormalities in patients with AS were posterior embryotoxon (95%), iris abnormalities (45%), diffuse fundus hypopigmentation (57%, a previously unreported finding), speckling of the retinal pigment epithelium (33%), and optic disc anomalies (76%). Microcornea was not associated with large refractive errors, and visual acuity was not significantly affected by these ocular changes. Vitamin levels were normal. Ocular abnormalities including posterior embryotoxon, iris abnormalities, and optic disc or fundus pigmentary changes were detected in one parent in 36% of cases. CONCLUSIONS: Alagille syndrome is associated with a characteristic group of ocular findings without apparent serious functional significance and probably unrelated to fat-soluble vitamin deficiency. Simple ophthalmic examination of children with neonatal cholestatic jaundice and their parents should allow early diagnosis of AS, eliminating the need for extensive and invasive investigations. PMID- 9951488 TI - Primary temporal fossa dermoid cysts. Characterization and surgical management. AB - OBJECTIVE: To detail the characteristics and management of rarely reported and incompletely described dermoid cysts originating in the temporal fossa. DESIGN: Retrospective case series. PARTICIPANTS: Five patients ranging from 2 to 38 years of age with a mass in the temporal region (posterior to the lateral orbital rim) participated. INTERVENTION: Computed tomography (CT) and excisional biopsy were performed. MAIN OUTCOME MEASURES: Clinical and CT characteristics and surgical outcomes were measured. RESULTS: Computed tomography showed cystic lesions, originating from the region anterior to the confluence of the greater wing of the sphenoid, frontal, and zygomatic bones. Displacement of the anteriormost portion of the temporalis muscle was common. Three cysts were isolated to the temporalis fossa, while two showed more extensive bony erosion and extension into the cranial and orbit cavities. At surgical excision, gross rupture of the cysts was noted in two cases, and two were completely liquefied. Histopathology showed variable inflammation surrounding all of the dermoid cysts. All patients did well after surgery. CONCLUSIONS: Dermoid cysts may infrequently occur "primarily" in the temporal fossa. Bone involvement and anterior temporalis muscle displacement are common. An origin from the area anterior to the confluence of the greater wing of the sphenoid, frontal, and zygomatic bones is seen. A coronal approach facilitates wide exposure and excision. When dural extension is suggested on CT, neurosurgical assistance may be required. PMID- 9951487 TI - Unilateral proptosis in an immunocompetent man as the initial clinical manifestation of systemic Hodgkin disease. AB - OBJECTIVE: Orbital involvement in Hodgkin disease (HD) is rare. Previously reported cases of HD in patients without the acquired immunodeficiency syndrome have been diagnosed late in the course of established systemic disease. The authors describe an immunocompetent man with orbital infiltration as the initial manifestation of systemic HD. DESIGN: Case report. PARTICIPANTS: A 47-year-old man with acute progressive, painless proptosis of the left eye is described. INTERVENTION: A well-defined, homogeneous soft tissue mass of the superior left orbit was evident on computed tomography, and an incisional biopsy of the nontender mass was performed. RESULTS: The histopathologic findings were characteristic of HD. Systemic investigations showed clinical stage 3A HD. Ten months after completion of hybrid chemotherapy, the patient remained in complete remission from his HD. CONCLUSION: Hodgkin disease presenting initially in the orbit of a patient with the acquired immunodeficiency syndrome has been described previously. The patient presented in this report is the first case of HD in the recent English literature with the initial manifestation in the orbit of an otherwise immunocompetent patient. PMID- 9951489 TI - The prevalence of herpes family virus DNA in the conjunctiva of patients positive and negative for human immunodeficiency virus using the polymerase chain reaction. AB - OBJECTIVE: To help understand the pathogenesis of herpes family virus ocular infection among patients positive for HIV, the authors compared the rates of detection of herpes family virus DNA from the conjunctiva of patients who are positive and negative for human immunodeficiency virus (HIV) using the polymerase chain reaction (PCR). DESIGN: Cross-sectional study. PARTICIPANTS: The conjunctival scrapings of 30 patients positive for HIV and 30 patients negative for HIV were examined. INTERVENTION: PCR was used to assay for the presence of herpes simplex virus type 1 (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) DNA (n = 240 samples). MAIN OUTCOME MEASURE: The rate of detection of virus DNA in the two groups, controlling for age, gender, and race, was measured. RESULTS: HSV and VZV DNA were not detected in any of the HIV-positive or HIV-negative samples. CMV DNA was detected in 20% (6 of 30) of patients positive for HIV and was undetected in control subjects negative for HIV (P = 0.01). EBV DNA was detected in 40% (12 of 30) of patients positive for HIV and in 47% (14 of 30) of control subjects negative for HIV (P = 0.58). CONCLUSIONS: There was no difference in the frequency of detection of HSV, VZV, or EBV DNA from the conjunctiva of patients positive or negative for HIV. Only CMV DNA was detected at a significantly higher rate in the conjunctiva of patients positive for HIV compared with control subjects negative for HIV. These different rates of peripheral virus shedding may be one possible explanation for the different rates of clinical infection among the herpes family viruses among patients positive for HIV. PMID- 9951490 TI - Pure ocular cicatricial pemphigoid. A distinct immunopathologic subset of cicatricial pemphigoid. AB - OBJECTIVE: To determine whether ocular cicatricial pemphigoid (OCP) may represent a distinct immunopathologic disease when it is pure ocular cicatricial pemphigoid (POCP) (e.g., only confined to the conjunctiva) or when it is associated with skin or extraocular mucous membrane lesions or both (OCP+). DESIGN: Prospective, immunologic, and immunopathologic study with special emphasis on direct immunoelectron microscopy. PARTICIPANTS: Six patients with POCP and seven patients with OCP+. INTERVENTION: After informed consent was obtained, a conjunctival biopsy was performed in all patients. Skin and extraocular mucosa biopsy specimens were harvested in selected cases only. MAIN OUTCOME MEASURES: Results of direct immunofluorescence and direct immunoelectron microscopy without freezing on conjunctival and skin biopsy specimens, indirect immunofluorescence, and Western immunoblotting analysis were analyzed. RESULTS: Results of direct immunoelectron microscopic examination of the conjunctiva showed the presence of immune deposits in the upper lamina lucida of the basement membrane zone in the six patients with POCP, whereas the immune reactants were located in the lower part of the lamina lucida and in the lamina densa of the basement membrane zone (conjunctiva, buccal mucosa, and skin) in the seven patients with OCP+. Direct immunofluorescence was positive in the biopsy specimens of three patients with POCP (50%) and the seven patients with OCP+ (100%). Results of indirect immunofluorescence study showed circulating autoantibody levels only in two patients with OCP+, and results of Western immunoblot analysis were negative. CONCLUSIONS: Results of direct immunoelectron microscopic examination of the conjunctiva support the hypothesis that POCP may be a disease entity distinct from mucocutaneous cicatricial pemphigoid. PMID- 9951491 TI - A randomized, double-masked, placebo-controlled parallel study of loteprednol etabonate 0.2% in patients with seasonal allergic conjunctivitis. AB - OBJECTIVE: To evaluate the effects of loteprednol etabonate (LE) 0.2% in reducing the signs and symptoms of seasonal allergic conjunctivitis. DESIGN: Randomized, double-masked, placebo-controlled, parallel group multicenter study of 6 weeks duration. PARTICIPANTS: A total of 135 patients with signs and symptoms of seasonal allergic conjunctivitis participated. INTERVENTION: All patients received either LE 0.2% or placebo (vehicle) four times a day in both eyes for 42 days. MAIN OUTCOME MEASURES: Bulbar conjunctival injection (primary sign) and itching (primary symptom) over the first 2 weeks of treatment was measured. RESULTS: A reduction in severity was seen in both LE and placebo groups for bulbar conjunctival injection (1.5 vs. 1.0 units on a 0-3 scale) and itching (3.4 vs. 3.0 units on a 0-4 scale) over the first 2 weeks. The treatment effect by these measures was -0.5 and -0.4 units in favor of LE (P < or = 0.008). Resolution (i.e., the proportion of patients with signs or symptoms no longer present) at day 14 strongly favored LE-treated patients (36% and 15%; 58% and 38%, for injection and itching, respectively). Both treatments were well tolerated. One patient in each treatment group (1 of 67 and 1 of 68, respectively) had an elevation of intraocular pressure of 10 mmHg or greater during the 6 weeks of treatment. CONCLUSIONS: Loteprednol etabonate 0.2% was more effective than placebo in the treatment of seasonal allergic conjunctivitis. Loteprednol etabonate 0.2% had a safety profile comparable to placebo. PMID- 9951492 TI - Mycophenolate mofetil. A useful immunosuppressive in inflammatory eye disease. AB - OBJECTIVE: To assess the usefulness of mycophenolate mofetil (MMF) (Cellcept, Roche), a potent selective uncompetitive and reversible inhibitor of ionisine monophosphate dehydrogenase involved in purine synthesis, as an immunosuppressive and steroid-sparing agent in the management of ocular inflammatory disease. DESIGN: Open-label, prospective, uncontrolled pilot study. PARTICIPANTS: Eleven patients with uncontrolled ocular inflammation. INTERVENTION: Mycophenolate mofetil, at a dosage of 1 g twice daily, was given in conjunction with steroids, as a steroid-sparing agent, or as an additional agent with cyclosporine (CsA), or instead of CsA or azathioprine. MAIN OUTCOME MEASURES: The inflammatory response, side effects, and toxicity were monitored. RESULTS: The addition of MMF to immunosuppressive regimens led to the improvement in symptoms and the ability to reduce the dose of prednisone in most patients. Ten of 11 patients showed a favorable response to MMF, with few side effects noted. CONCLUSION: These findings suggest that MMF is a useful immunosuppressive drug for controlling ocular inflammation with minimal side effects. PMID- 9951493 TI - Comparison of tranexamic acid and prednisolone in the treatment of traumatic hyphema. A randomized clinical trial. AB - OBJECTIVE: Oral antifibrinolytics, oral steroids, and no oral treatment are the preferred medical treatments for traumatic hyphema. Antifibrinolytics and steroids have decreased the chance of rebleeding in some studies but failed to alter the clinical course in others. Rate of secondary hemorrhage seems variable among different geographic and ethnic groups of patients. Comparison of the treatments in each population is necessary to document the most effective method of preventing recurrent hemorrhage. DESIGN: Randomized, placebo-controlled, clinical trial. PARTICIPANTS: Two hundred thirty-eight patients in whom hyphema developed after a blunt trauma entered the study. INTERVENTION: Eighty patients received 75 mg/kg per day oral tranexamic acid (TA) divided into 3 doses, 80 patients received a placebo with the same number of tablets and frequency as those of the TA group, and 78 patients received 0.75 mg/kg per day oral prednisolone divided into 2 doses. MAIN OUTCOME MEASURE: Secondary hemorrhage during the hospital course was measured. RESULTS: Secondary hemorrhage occurred in 8 patients (10%) of the TA group, 14 patients (18%) of the prednisolone group, and 21 patients (26%) of the placebo group. The difference between the incidence of rebleeding between TA and placebo groups was statistically significant (P = 0.008). Patients receiving a placebo had a greater chance of secondary bleeding than did patients receiving TA (odds ratios = 3.2; 95% confidence interval = 1.3, 7.5). The incidences of rebleeding were not significantly different in placebo versus prednisolone groups (P = 0.21) and TA versus prednisolone groups (P = 0.15). CONCLUSION: In a population with a high rate of secondary bleeding, TA is more effective than oral prednisolone or no oral treatment in preventing rebleeding among patients with traumatic hyphema. PMID- 9951494 TI - An analysis of risk for secondary hemorrhage in traumatic hyphema. AB - OBJECTIVE: Factors such as size of hyphema, intraocular pressure, initial visual acuity, and use of steroids or antifibrinolytic drugs may be associated with the likelihood of rebleeding in traumatic hyphema. The association of the visual outcome with secondary hemorrhage has been questioned. DESIGN: Randomized, placebo-controlled, clinical trial. PARTICIPANTS: Two hundred and thirty-eight patients who had hyphema develop after blunt trauma. INTERVENTION: Eighty patients received oral tranexamic acid, 80 patients received placebo, and 78 patients received oral prednisolone. MAIN OUTCOME MEASURES: Secondary hemorrhage and vision at the time of discharge from the hospital were measured. RESULTS: Rebleeding occurred in 43 (18%) of the patients and was prevented significantly by oral tranexamic acid compared with the placebo (odds ratios [OR] = 0.39; 95% confidence interval [CI], 0.17, 0.89). Occurrence of secondary hemorrhage had weak associations with initial high intraocular pressure (OR = 2.7; 95% CI, 0.99, 7.3) and initial visual acuity of 6/60 or less (OR = 1.8; 95% CI, 0.9, 3.7). Secondary hemorrhage had no statistical association with age, gender, oral prednisolone, size of hyphema, and retinal damage. Visual acuity of 6/60 or less at the time of discharge was significantly associated with rebleeding (OR = 10.5; 95% CI, 3.7, 29.2), initial visual acuity of 6/60 or less (OR = 9.9; 95% CI, 2.8, 38.0), retinal damage (OR = 14.6; 95% CI, 3.8, 55.8), and male gender (OR = 6.5; 95% CI, 1.4, 31.9). Final visual acuity had no significant statistical association with age, use of oral prednisolone or tranexamic acid, and size of hyphema. CONCLUSIONS: High intraocular pressure and low vision at the time of first examination may be associated with increased chance of rebleeding. Retinal damage, secondary hemorrhage, male gender, and initial poor vision are associated with a worse visual outcome in patients with traumatic hyphema. PMID- 9951495 TI - The additive effect of latanoprost to maximum-tolerated medications with low dose, high-dose, or no pilocarpine therapy. AB - OBJECTIVE: To assess the efficacy of latanoprost additive therapy in patients with intraocular pressure (IOP) out of control while taking maximum-tolerated medications and to determine whether pilocarpine therapy has a dose-dependent adverse effect on the efficacy of latanoprost therapy. DESIGN: Noncomparative case series. PARTICIPANTS: Sixty-one eyes of 61 patients with chronic glaucoma with IOP out of control while receiving maximum-tolerated medications were treated with latanoprost additive therapy on a compassionate basis. MAIN OUTCOME MEASURES: Follow-up was up to 22 months with a mean of 13.9 +/- 5.7 months. Kaplan-Meier survival analysis with Mantel-Cox log-rank test was performed to determine the overall success of latanoprost additive therapy and to compare the success rates of high-dose pilocarpine, low-dose pilocarpine, and no pilocarpine therapies. The criterion for success was avoiding glaucoma surgery with IOP decrease of 20% or greater and final IOP less than 22 mmHg. The IOP change and its significance for patients satisfying and failing the criterion for success also were determined to assess the latanoprost additive therapy. In addition, a number of pretreatment variables, including pilocarpine therapy, were analyzed for a significant effect on the efficacy of latanoprost additive therapy using Cox proportional hazards regression analysis. RESULTS: Latanoprost additive therapy significantly lowered mean IOP by 3.9 +/- 5.5 mmHg at 3 months and by 3.5 +/- 5.8 mmHg at 12 months. The cumulative success rate of the latanoprost additive therapy was 70% at 1 month, 42% at 3 months, 40% at 6 months, and 30% at 12 months. Of the variables studied, only increased number of previous incisional glaucoma surgeries and IOP greater than 24 mmHg before latanoprost additive therapy were significant prognostic factors for failure of latanoprost additive therapy. Pilocarpine therapy in any dose had no significant effect. CONCLUSION: This study supports a trial of latanoprost additive therapy before glaucoma surgery in patients with IOP out of control while receiving maximum-tolerated medications irrespective of pilocarpine therapy and the pilocarpine dosage, especially when the number of previous incisional glaucoma surgery is less than three and the IOP is less than 25 mmHg. PMID- 9951496 TI - Scoring systems for measuring progression of visual field loss in clinical trials of glaucoma treatment. AB - OBJECTIVES: To compare the statistical properties of two visual field scoring systems used by clinical trials of glaucoma treatments with a view to their performance as longitudinal measures of visual field progression. DESIGN: Cohort study comparing the scoring systems used by the Advanced Glaucoma Intervention Study (AGIS) and the Collaborative Initial Glaucoma Treatment Study (CIGTS) using pairs of visual fields (C-30-2 of the Humphrey Analyzer) spaced 1 year apart. PARTICIPANTS: Sixty-seven eyes of 56 subjects with glaucomatous visual field loss from a natural history study of glaucoma were examined. METHODS: Because both scoring systems are scaled so that they range from 0 to 20, the AGIS and CIGTS scores were compared by scatterplot, Pearson correlation, and the mean difference between scores. The difference between pairs of scores 1 year apart was used to compare the temporal variability of each scoring system. The proportion of subjects whose visual field "deteriorated" in 1 year by the amount specified for unconfirmed progression in each clinical trial was calculated. MAIN OUTCOME MEASURES: Mean difference in scores 1 year apart and the variance of these differences were measured. RESULTS: The median scores for the first of the two fields was 5.2 (interquartile range [IQR] = 9.8) for CIGTS and 5.0 (IQR = 7.0) for AGIS. The CIGTS scores were slightly larger than AGIS scores by an average of 0.5 (P = 0.06). The mean CIGTS score of the baseline fields was 0.06 (standard deviation = 3.8) higher than the mean of the second fields and 0.12 (standard deviation = 2.8) higher for AGIS. Fifteen percent of eyes had CIGTS scores that deteriorated by three or more (the cutoff for unconfirmed progression) over 1 year, while 7.5% of eyes had AGIS scores that deteriorated by four or more (the AGIS cutoff for unconfirmed progression) over the same period. Twenty-one percent improved by CIGTS criteria, while 12% improved by AGIS criteria. CONCLUSIONS: CIGTS scores are systematically slightly higher than AGIS scores. The CIGTS scoring system has higher temporal variability than the AGIS system. The CIGTS criterion for unconfirmed progression over a 1-year period is likely to lead to higher estimated rates of progression than the AGIS criteria. This is mostly because of the difference in the definition of progression between the two study criteria. PMID- 9951497 TI - Combined penetrating keratoplasty and trabeculectomy with mitomycin C. AB - OBJECTIVE: To evaluate corneal graft survival and intraocular pressure control in eyes that have undergone combined penetrating keratoplasty and trabeculectomy with mitomycin C (MMC). DESIGN: Retrospective noncomparative case series. INTERVENTION: Penetrating keratoplasty combined with trabeculectomy with MMC and other surgical procedures. PARTICIPANTS: Twenty-four eyes of 22 patients undergoing combined penetrating keratoplasty and trabeculectomy with mitomycin C. MAIN OUTCOME MEASURES: Corneal graft clarity and intraocular pressure control. RESULTS: The cumulative probability of corneal graft survival was 85% at 1 year and 60% at 2 years. The cumulative probability of adequate pressure control was 67% at 3 months, 55% at 12 months, and 50% at 24 months. The incidence of bleb failure was higher in cases involving additional concomitant procedures, such as anterior vitrectomy, lens implantation or exchange, and drainage tube implantation. CONCLUSIONS: Combined penetrating keratoplasty and trabeculectomy with mitomycin C is associated with good corneal graft survival but also a risk of early failure of intraocular pressure control. Other concomitant procedures during the combined penetrating keratoplasty/trabeculectomy may increase the risk of early bleb failure. PMID- 9951498 TI - The associations between self-rated vision and hearing and functional status in middle age. AB - OBJECTIVES: To describe the associations between self-reported visual and hearing impairment and an index of global functional status among community-dwelling, middle-aged Americans. DESIGN: Cross-sectional. PARTICIPANTS: A total of 9744 U.S. community-dwelling persons 51 to 61 years of age participated. METHODS: Multivariate analyses of functional status based on cross-sectional data from Wave I (1992) of the Health and Retirement Study (HRS), controlling for demographic and socioeconomic status, common chronic medical conditions, and general health status, were performed. MAIN OUTCOME MEASURE: A global index of functional status based on self-reported limitations in 17 activities was measured. RESULTS: Approximately 3% of respondents in the HRS rated their vision or hearing as poor. Even after controlling for demographic factors, socioeconomic status, medical conditions, and general health status, limitations in both vision and hearing were independently correlated with worse functional status. In addition, controlling for income, wealth, and education reduced the strength of the associations between vision and hearing impairment and function, but did not eliminate them. The magnitude of effect of poor vision exceeded all medical conditions except stroke. CONCLUSIONS: Visual and hearing impairment appear to have a significant relationship with overall functional status, among even community-dwelling, middle-aged Americans and even after controlling for general health status, medical comorbidities, and socioeconomic status. PMID- 9951499 TI - Posterior corneal surface topographic changes after laser in situ keratomileusis are related to residual corneal bed thickness. AB - OBJECTIVE: To determine whether ectasia after laser in situ keratomileusis (LASIK) is related to residual corneal bed thickness. DESIGN: Retrospective noncomparative case series. PARTICIPANTS: Thirty-two eyes of 16 patients with refractive errors of -4.00 to -18.00 diopters were examined. INTERVENTION: LASIK was performed. The topography of the posterior corneal surface was examined with the Orbscan slit scanning corneal topography/pachymetry system. MAIN OUTCOME MEASURES: The difference in the elevation of posterior corneal surface regarding the best-fit sphere was measured. RESULTS: After surgery, mean bulge of 17.2 +/- 7.2 microns was found in eyes with residual corneal bed of 250 microns or greater, whereas 41.0 +/- 22.1 microns was seen in eyes with bed thickness less than 250 microns (t = 4.29; P = 0.000). CONCLUSION: Posterior corneal bulge is correlated with the residual corneal bed thickness. The risk of ectasia may be increased if the residual corneal bed is thinner than 250 microns. PMID- 9951500 TI - Comparison of photorefractive keratectomy with excimer laser in situ keratomileusis in correcting low myopia (from -2.00 to -5.50 diopters). A randomized study. AB - OBJECTIVE: To compare laser in situ keratomileusis (LASIK) with photorefractive keratectomy (PRK) in the correction of myopia from -2.00 to -5.50 diopters. DESIGN: Prospective, randomized, paired clinical trial. PARTICIPANTS: Fifty-two eyes of 26 myopic patients were enrolled in the study. INTERVENTION: Each patient received PRK on one eye (PRK eye) and LASIK on the other (LASIK eye); the procedure assigned to each eye, and the sequence of surgeries for each patient was randomized. MAIN OUTCOME MEASURES: Slit-lamp microscopy, manifest refraction, uncorrected and spectacle-corrected visual acuity, and videokeratography were done before operation, and 2 weeks, 6 weeks, 3 months, 6 months, and 12 months after operation. Patient satisfaction and preference were assessed by a subjective questionnaire. RESULTS: All LASIK eyes had fast, painless recovery. At 1 year, 24 patients (92.3%) were examined, the mean spherical equivalent refraction was -0.08 +/- 0.38 diopter in the PRK eyes and -0.14 +/- 0.31 diopter in the LASIK eyes, and the uncorrected visual acuity was 20/20 or better in 15 PRK eyes (62.5%) and 19 LASIK eyes (79.2%); no eye lost 2 or more Snellen lines of spectacle-corrected visual acuity. Both procedures were stable throughout the first year. One PRK eye developed dense subepithelial corneal haze. The strongest correlate to spectacle-corrected visual acuity after the two procedures was the coefficient of variation of corneal power over the pupil. Nineteen patients (79.2%) preferred the LASIK procedure because of the fast, painless recovery. CONCLUSIONS: In the current study, PRK and LASIK were found to be similarly effective, predictable, stable, and reasonably safe for the correction of myopia between -2.00 and -5.50 diopters. Laser in situ keratomileusis has the advantage of fast, painless recovery. Patients prefer LASIK. PMID- 9951501 TI - Excimer laser photorefractive keratectomy (PRK) for myopia and astigmatism. American Academy of Ophthalmology. AB - The purpose of the Committee on Ophthalmic Procedures Assessment is to evaluate on a scientific basis new and existing ophthalmic tests, devices, and procedures for their safety, efficacy, clinical effectiveness, and appropriate uses. Evaluations include examination of available literature, epidemiologic analyses when appropriate, and compilation of opinions from recognized experts and other interested parties. After appropriate review by all contributors, including legal counsel, assessments are submitted to the Academy's Board of Trustees for consideration as official Academy policy. PMID- 9951503 TI - [Jaundice with free bilirubin following preventive anti-retroviral therapy after sexual aggression]. AB - BACKGROUND: Interest has recently focused on anti-HIV prophylaxis in case of sexual exposure. A circular from the French Ministry of Health (DGS/DH n(o) 97/560, 12 August 1997) envisages such treatment in certain risk situations such as sexual aggression. The toxic risk of prescribing a tritherapy or a bitherapy, even for a short period of a few weeks must be considered. CASE REPORT: A 20-year old rape victim with an uneventful medical history was given a prophylactic regimen including zidovudine, laminovudine and indinavir. Three months later, she developed free-bilirubin jaundice with biological signs of hemolysis. DISCUSSION: We draw attention to the risk of severe adverse effects of short-duration anti HIV prophylaxis in apparently healthy subjects. The protocol must included careful patient information and rigorous surveillance. PMID- 9951504 TI - [Essential arterial hypertension treated with rilmenidin : what dose for what patient?]. AB - OBJECTIVE: To study the therapeutic interest of dose adaptation from 1 mg to 2 mg daily when treating essential hypertension with rilmenidine in monotherapy, in terms of normalisation of blood pressure, of clinical tolerance and of laboratory parameters. METHODS: In a non-comparative multicentre study conducted in France in patients with essential hypertension, rilmenidine was started at 1 mg daily. When the target blood pressure was not achieved (supine diastolic blood pressure (DBP) < or = 90 mm Hg) after 6 weeks, the dose was adapted to 2 mg daily. For persistent non-responders, a second antihypertensive was added from 3 months and a third from 6 months as necessary. Total follow up was for 12 months. RESULTS: Eighteen thousand two hundred and thirty five (18,235) patients of either sex, average age 61.2 years and 90 mm Hg < supine DBP < 115 mm Hg were included. Sixteen thousand four hundred and ninety six (16,496) patients were followed for 12 months with complete data being available for 15,963 of them., 13,565 (84.9%) were treated with rilmenidine in monotherapy, 9,626 (60.3%) at 1 mg daily, and 3,939 (24.6%) at 2 mg daily. For patients who were treated with rilmenidine 1 mg daily throughout the study, mean reduction of blood pressure between D0 and M12 was -27.5/-18.9 mm Hg. Mean reduction was -30.0/-20.3 mm Hg for those who completed the study on 2 mg per day. 82.8% of the analysed population were normalised with rilmenidine in monotherapy, 59.1% with 1 mg daily. Dose adaptation to 2 mg normalised an additional 23.7% of patients. Rilmenidine monotherapy was associated with good clinical and laboratory acceptability. CONCLUSION: The step-wise adaptation of rilmenidine dose in the treatment of essential hypertension is justified by the superior normalisation rate achieved by increasing the dose from 1 mg to 2 mg daily. This adaptation neither increases side effects nor changes laboratory parameters. These data support dose adaptation of rilmenidine monotherapy before association with another antihypertensive. However, neither ther blood pressure level nor associated risk factors predict the type of patients who will be normalised by 1 mg daily or those who require 2 mg. The practice of always starting rilmenidine at 1 mg daily in essential hypertension is therefore supported. PMID- 9951505 TI - [What about hyperglycerolemia?]. PMID- 9951506 TI - [HLA-G-related repeat abortions with histological characteristics of organ rejection]. PMID- 9951502 TI - [Organ procurement from cardiac arrest donors: outcome of kidney grafts and recommendations]. AB - OBJECTIVES: To compare literature data with results obtained with organs procured from donors who died from cardiac arrest and to make proposals for this mode of organ procurement in France. METHODS: Over the last 10 years, 10 organ donors (2%) among a series of 486 donors in a state of brain death, had died of cardiac arrest. The arrest were perfused with double-balloon catheters. The outcome of the subsequent kidney grafts was compared with data in the literature. RESULTS: Fifteen of the 18 kidneys from cardiac arrest donors were functioning 1 month after implantation compared with 17 of the 20 kidneys from braindeath donors with beating hearts. The rate of acute tubular necrosis was 55% in the cardiac arrest kidneys and 40% in the beating-heart kidneys. Serum creatinine at 1 yeart was 145 +/- 69 mumol/l 17 +/- 29 mumol/l respectively. DISCUSSION: These results and those reported in the literature demonstrate that kidney procurement from cardiac arrest donors is feasible. If intensive care and surgery units are well organized, this type of organ procurement could provide a larger number of organs for transplantation. Emergency teams must be available for preparing and transferring the organs. PMID- 9951507 TI - [Quincke's edema during ticlopidine treatment]. PMID- 9951508 TI - [Optimizing antibiotic therapy in a hospital setting]. AB - Optimal use of antibiotics in hospitalized patients raises several problems. i) Does the patient really have an infection treatable with antibiotics? Currently, there are no clinical or biological data which can resolve this question with sufficient sensitivity and specificity. ii) Are microbial samples warranted before starting treatment? All bacteria isolated from cerebrospinal, ascitis, pleural or articular fluids are pathogens whereas a quantitative assessment is required for bacteria isolated from the upper or lower respiratory tract. iii) If an antibiotic is needed should a single drug or a multiple drug regimen be prescribed? Twenty years ago two-drug regimens were necessary. Synergism and better spectrum were the keystones of two-drug therapy. Today, single-drug regimens are sufficient except in case of Staphylococcus, Pseudomonas or some Enterobacteriacae infections. iv) Which administration route is best? In hospitalized patients, the parenteral route is generally used with a rapid switch to oral administration, usually within 48 hours. v) How long should the antibiotics be given? Treatment duration depends on the bacteria, the patient and the organ involved. vi) How can resistance be avoided? Rotating between antibiotics has been proposed to reduce the emergence of multidrug resistant bacteria, although this concept remains to be validated by controlled studies. PMID- 9951509 TI - [Mediterranean visceral leishmaniasis: physiopathology]. AB - INFANTILE LEISHMANIASIS: The protozoan parasites of the genus Leishmania are the causal agent of various diseases ranging from cutaneous lesions to fatal systemic diseases. In southern France, Leishmania infantum is an endemic species recognized as the causal agent of infantile leishmaniasis (Mediterranean visceral leishmaniasis). Little is known about the pathophysiology of the disease in humans, but models in mice may provide a new approach. INSECT VECTOR: Leishmania infantum are carried by sand flies. Antigenic modifications of the promastigote forms occur in these insects modifying lipophyosphoglycan (LPG) or glyocprotein gp63. Salivary gland lysates from the sand flies also enhance Leishmania infectivity. HUMAN INFESTATION: In humans, LPG and gp63 play a role in complement fixation, cell adhesion and resistance to complement-mediated lysis. Macrophage expression of class I and II major histocompatibility complex antigens is suppressed. T cells and interferon gamma are very important keys in the control of the parasite infection. PMID- 9951510 TI - [Contribution of molecular cytogenetics to the diagnosis of chromosome anomalies]. AB - MOLECULAR CYTOGENETICS: New fluorescent in situ hybridization (FISH) techniques have been developed using fluorescent non-radioactive DNA probes. FISH: Based on the complementary of nucleotides FISH enables visualization and localization of a DNA fragment on chromosomes by hybridizing the complementary DNA sequence, the probe. Many types of tissues can be analyzed, for example hematopoietic cells in blood or bone marrow, amniotic cells, trophoblasts, fibroblasts, gamete or tumoral cells. APPLICATIONS: Molecular cytogenetics can be used to characterize chromosome anomalies in many fields of cytogenetics (constitutional studies, prenatal diagnosis, hematology, oncology). PMID- 9951512 TI - [Comparison of different 3-dimensional irradiation techniques in local radiotherapy of prostatic carcinoma]. AB - PURPOSE: Four different three-dimensional planning techniques for localized radiotherapy of prostate cancer were compared with regard to dose homogeneity within the target volume and dose to organs at risk, dependent upon tumor stage. PATIENTS AND METHODS: Six patients with stage T1, 7 patients with stage T2 and 4 patients with stage T3 were included in this study. Four different 3D treatment plans (rotation, 4-field, 5-field and 6-field technique) were calculated for each patient. Dose was calculated with the reference point at the isocenter (100%). The planning target volume was encompassed within the 95% isodose surface. All the techniques used different shaped portal for each beam. Dose volume histograms were created and compared for the planning target volume and the organs at risk (33%, 50%, 66% volume level) in all techniques. RESULTS: The 4 different three dimensional planning techniques revealed no differences concerning dose homogeneity within the planning target volume. The dose volume distribution at organs at risk show differences between the calculated techniques. In our study the best protection for bladder and rectum in stage T1 and T2 was achieved by the 6-field technique. A significant difference was achieved between 6-field and 4 field technique only in the 50% volume of the bladder (p = 0.034), between the 6 field and rotation technique (all volume levels) and between 5-field and rotation technique (all volume levels). In stage T1, T2 6-field and 4-field technique in 50% (p = 0.033) and 66% (p = 0.011) of the rectum volume. In stage T3 a significant difference was not observed between the 4 techniques. The best protection of head of the femur was achieved by the rotation technique. CONCLUSION: In the localized radiotherapy of prostate cancer in stage T1 or T2 the best protection for bladder and rectum was achieved by a 3D-planned conformal 6-field technique. If the seminal vesicles have been included in the target volume and in the case of large planning target volume other techniques should be taken for a better protection for organs at risk e. g. a 3D-planned 4-field technique box technique. PMID- 9951511 TI - Blood flow and oxygenation status of human tumors. Clinical investigations. AB - PURPOSE: There is a large body of evidence suggesting that blood flow and oxygenation of human tumors are important research topics which may explain, in particular, resistance to radiation and to many antineoplastic drugs, which can limit the curability of solid tumors by radiotherapy and chemotherapy. MATERIALS AND METHODS: This manuscript reviews the clinical investigations which have been performed regarding blood flow and oxygenation status of human tumors in radiation oncology. RESULTS: The possible uses and limitations of the prognostic significance and the changes under therapy measuring blood flow and oxygenation in human tumors were discussed. In addition, several approaches were summarized, which can improve the microvascular O2 availability and perfusion-limited O2 delivery. CONCLUSION: The clinical data concerning the prognostic significance of blood flow, vascular function and oxygenation of human tumors are relevant for patient selection in clinical oncology. Strategies to improve traditional cancer therapy by modulation of the oxygenation status remain quite promising but more critical research and sophisticated clinical studies are necessary before its true potential is known. PMID- 9951513 TI - Interstitial brachytherapy in carcinoma of the penis. AB - AIM: Keeping in line with the increasing emphasis on organ preservation, we at the Tata Memorial Hospital have evaluated the role of Ir-192 interstitial implant as regards local control, functional and cosmetic outcome in early as well as locally recurrent carcinoma of the distal penis. PATIENTS AND METHODS: From October 1988 to December 1996, 23 patients with histopathologically proven cancer of the penis were treated with radical radiation therapy using Ir-192 temporary interstitial implant. Our patients were in the age group of 20 to 60 years. The primary lesions were T1 in 7, T2 in 7 and recurrent in 9 patients. Only 7 patients had palpable groin nodes at presentation, all of which were pathologically negative. The median dose of implant was 50 Gy (range 40 to 60 Gy), using the LDR afterloading system and the Paris system of implant rules for dosimetry. Follow-up ranged from 4 to 117 months (median 24 months). RESULTS: At last follow-up 18 of the 23 patients remained locally controlled with implant alone. Three patients failed only locally, 2 locoregionally and 1 only at the groin. Of the 5 patients who failed locally, 4 were successfully salvaged with partial penectomy and remained controlled when last seen. Local control with implant alone at 8 years was 70% by life table analysis. The patients had excellent functional and cosmetic outcome. We did not record any case of skin or soft-tissue necrosis. Only 2 patients developed meatal stenosis, both of which were treated endoscopically. CONCLUSION: Our results lead us to interpret that interstitial brachytherapy with Ir-192 offers excellent local control rates with preservation of organ and function. Penectomy can be reserved as a means for effective salvage. PMID- 9951514 TI - Radiation-induced bilateral optic neuropathy in cancer of the nasopharynx. Case failure analysis and a review of the literature. AB - CASE REPORT: A case history of unanticipated radiation-induced bilateral optic neuropathy, 18 months after induction chemotherapy and radiation therapy for a locally advanced nasopharyngeal carcinoma, is presented. Retrospective reanalysis of the radiation therapy technique, with emphasis on the doses received by the optic pathway structures, was performed. These re-calculations revealed unexpectedly high doses in the range 79 to 82 Gy (cumulative external and brachytherapy dose) at the level of the optic nerves, which explained the observed radiation injury. CONCLUSION: Routine implementation of computed tomography for 3D dose planning purposes is therefore advocated. Review of the current literature confirms the importance of 3D dose planning in avoiding this complication and high-lights the role of MRI in establishing the diagnosis of radiation-induced optic neuropathy. PMID- 9951515 TI - Effect of amifostine (Ethyol) on the development of extraembryonic blood vessels in chick embryos. AB - AIM: Systemic and local side effects can limit radio- as well as chemotherapy in patients suffering from neoplastic diseases. One possibility to reduce the therapy-dependent side effects is to attenuate radical induced alterations of normal healthy tissue by application of antioxidants. Preclinical and clinical studies demonstrated the ability of amifostine to protect normal, but not neoplastic, tissues from cytotoxic effects of chemotherapy or irradiation. The purpose of the present study was to establish whether amifostine (Ethyol) can affect microvessel density in vivo. MATERIAL AND METHODS: For this study fertilized crossbred "White-Plymouth-Rocks x Sussex" eggs were used. After 48 hours of incubation 0.05 ml solution containing 25.7 micrograms (approximately 120 microM) amifostine were injected next to the germ disc. Taking into account the mean surface area of the are vasculosa and the embryo, this corresponds to a dose of 26 micrograms/cm2. As controls, the area vasculosa of eggs treated with 0.05 ml NaCl 0.9% were used. Twenty-four and 48 hours after injection of amifostine or NaCl photographs and video microscopic pictures from treated areas and controls were taken and evaluated for vascular density. Results of vascular density are given as vascular intersections per mm2 (VIS/mm2). RESULTS: There was a significant (p < 0.001) difference in vascular density with a mean microvessel count of 30.40 (+/- 12.84 SD) VIS/mm2 in the NaCl control and 53.69 (+/- 24.56 SD) VIS/mm2 in the amifostine-treated area vasculosa. CONCLUSION: The results show that amifostine induced an increase in vascular density in the rapidly proliferating area vasculosa of the early chick embryo. PMID- 9951516 TI - Lymphatic metastasis from tumors transplanted into the pre-irradiated footpad of the rat. AB - BACKGROUND: In the literature there is some evidence that the incidence of metastases may increase after radiation treatment. METHODS: In order to investigate whether radiation-induced changes in the lymphatic drainage may alter the rate of lymph node metastasis, the center part of the left hind foot of rats was irradiated with a dose of 1 x 55 Gy before inoculation of tumor cells into the irradiated part of the footpad at different time intervals. Cells of 2 different tumor lines were employed. A rarely metastasising rhabdomyosarcoma, R 1, to look for a possible enhancement of lymphatic metastases, and a readily metastasising mammary carcinoma, Cl-2, in case of a possible decrease in the rate of lymphatic metastasis from tumors growing in pre-irradiated footpads. RESULTS: The incidence of regional lymph node metastasis decreased for R-1 tumors growing in pre-irradiated footpads, but not for Cl-2 tumors. Furthermore, the average time required for lymph node metastasis to attain a reference volume of 100 mm3 is not significantly influenced by pre-irradiation of the footpad. No difference was observed in average times for doubling in volume of lymph node metastases originating from primary tumors in pre-irradiated footpads. Abscopal effects after footpad irradiation may cause a 50-fold increase in size of regional lymph nodes and, therefore, histological examination is essential for verification of lymph node metastases. CONCLUSIONS: Damage to the lymphatic system to be expected in the irradiated footpad did not enhance the incidence of regional metastasis of R-1 tumors. A reduced rate of lymphatic metastasis contradicts earlier findings of enhanced lymphatic metastasis development of R-1 tumors, growing in pre irradiated gastrocnemius muscles. The influence of irradiation on regional metastasis formation seems to be "tumor bed" dependent for R-1 tumors. PMID- 9951517 TI - [A method of quality assurance of dynamic wedges]. AB - BACKGROUND: One of the important prerequisites for using a virtual wedge is the availability of an appropriate method for quality assurance. A simple method to determine wedge angles has been developed. MATERIAL AND METHODS: A formula based on the exponential attenuation curve has been derived, that allows for the calculation of the wedge isodose angles based on 2 measurement points perpendicular to the central ray. The linear attenuation coefficient is the only variable that must be known for the field size under consideration. RESULTS: Using the algorithm introduced, the wedge angle isodoses can be measured with a high degree of accuracy. The deviation of the wedge angle compared to the measurements done according to DIN 6847-4 is less than 1 degree. CONCLUSION: The described procedure is a simple method of performing routine quality assurance for the virtual wedge. PMID- 9951518 TI - [Survival time of exclusively irradiated NSCLC patients: the viewpoint of a clinical biologist. Concerning the article by R. Wilhelm et al in Strahlenther Onkol 1988: 174:128-32 (No. 3)]. PMID- 9951519 TI - [Erectile function after treatment of prostatic carcinoma]. PMID- 9951520 TI - [Meta-analysis of prognostic significance of tumor cell demonstration in the bone marrow or: "Looking for an independent prognostic factor"]. PMID- 9951522 TI - An integrated process for the production of toxic catechols from toxic phenols based on a designer biocatalyst. AB - We describe the biocatalytic production of 3-phenylcatechol from 2-phenylphenol with the whole cell biocatalyst Escherichia coli JM101 (pHBP461). The recombinant produces 2-hydroxybiphenyl 3-monooxygenase, an enzyme from Pseudomonas azelaica HBP1. This enzyme introduces a hydroxyl-group at the C3-position of a variety of 2-substituted phenols, such as 2-phenylphenol. This permits the biocatalytic production of 3-substituted catechols, which are difficult to synthesize chemically. Both 2-phenylphenol and 3-phenylcatechol are highly toxic to E. coli. The toxic effects of 2-phenylphenol were minimized by feeding this substrate to the reactor at a rate slightly below the maximum biooxidation rate. As a result, the substrate concentration in the reactor remained below toxic levels during the bioconversion. The toxic product formed was removed by continuous adsorption on the solid resin Amberlite XAD-4. To this end the reaction mixture, containing the biocatalyst, was pumped continuously through an external loop with a fluidized bed of the resin. This resin efficiently and quantitatively adsorbed both 3 phenylcatechol and the remaining trace amounts of 2-phenylphenol. Consequently, the concentrations of these compounds were kept at subtoxic levels (below 100 mg L-1) and gram amounts of 3-phenylcatechol were produced with space-time yields of up to 0.39 g L-1 h-1. The product was recovered from the resin by acidic methanol elution and purified by recrystallization from n-hexane resulting in overall yields exceeding 59%. The optimized system served as a surprisingly simple and efficient integrated process, that allows the bioconversion of toxic substrates to toxic products with whole cell biocatalysts. PMID- 9951521 TI - Apoptosis in batch cultures of Chinese hamster ovary cells. AB - One of the main problems in the culture of Chinese Hamster Ovary (CHO) cells continues to be the inability to maintain the viability of the cultures over an extended period of time. The rapid decline in viability at the end of the culture is exacerbated by the absence of serum. In trying to reduce the extent of death in these cultures, we first tried to determine the mode of death. We found that more than 80% of the cells in a standard serum-free batch culture of CHO cells in suspension died via apoptosis--as evidenced by condensed chromatin and the appearance of a characteristic DNA ladder. Furthermore, when protein synthesis was inhibited using cycloheximide, the cells underwent rapid apoptosis indicating that death proteins were present in greater abundance than survival proteins in our CHO cells. Cell lysate from CHO cells showed evidence of cysteine protease (caspase) activity. Caspases of the Interleukin-1-beta-Converting Enzyme (ICE) family, e.g., CPP32, Mch-1, etc., have been implicated in the apoptotic process. Surprisingly, a caspase peptide inhibitor, N-benzyloxycarbonyl-Val-Ala-Asp-fluoro methyl-ketone (z-VAD.fmk), was unable to substantially extend the life of a serum free batch culture of CHO cells. In addition, z-VAD.fmk was only marginally able to extend viability in response to withdrawal of growth and survival factors, insulin and transferrin. In both these instances, z-VAD.fmk was able to prevent cleavage of caspase substrates, but not protect cells from death. However, we found that bcl-2 expression was able to significantly extend viabilities in CHO batch culture. Bcl-2 expression also substantially extended the viability of cultures in response to insulin and transferrin withdrawal. These results provide interesting insights into the pathways of death in a CHO cell. PMID- 9951523 TI - Fractionation of gliadin hydrolysates in water-ethanol by ultrafiltration with modified or unmodified membranes. AB - Ultrafiltration was applied to the fractionation of neutral vs. charged peptides of similar size. The peptides, produced from gliadins, a major fraction of wheat storage proteins, were obtained by limited hydrolysis with alpha-chymotrypsin in water-ethanol 80/20 (v/v). Peptides, according to their elution by RP-HPLC, were quasineutral (repetitive peptides) irrespective of pH, or positively charged (nonrepetitive peptides) at pH below 5. The transmission through the membranes of the nonrepetitive peptides was less (until sevenfold) than that of the repetitive ones, because of the role of electrostatic repulsion involved in the retention of charged solutes. The difference of transmission was more efficient at acidic pH (3) and low ionic strength with inorganic membranes and in a wider range of pH and ionic strength with membranes modified by coating of positively charged polymers (polyvinylimidazole PVI, polyethyleneimine PEI). A continuous diafiltration process using an inorganic membrane of low molecular cut-off permitted the selective enrichment of the retentate in nonrepetitive peptides (up to 80%) and of the permeate in repetitive peptides (up to 80%) from hydrolysate feed containing about 60/40% of repetitive and nonrepetitive peptides, respectively, with a diafiltration volume of 4. PMID- 9951525 TI - Probing the disulfide folding pathway of insulin-like growth factor-I. AB - The crucial step of folding of recombinant proteins presents serious challenges to obtaining the native structure. This problem is exemplified by insulin-like growth factor (IGF)-I which when refolded in vitro produces the native three disulfide structure, an alternative structure with mispaired disulfide bonds and other isomeric forms. To investigate this phenomenon we have examined the refolding properties of an analog of IGF-I which contains a 13-amino acid N terminal extension and a charge mutation at position 3 (Long-[Arg3]IGF-I). Unlike IGF-I, which yields 45% of the native structure and 24% of the alternative structure when refolded in vitro, Long-[Arg3]IGF-I yields 85% and 10% of these respective forms. To investigate the interactions that affect the refolding of Long-[Arg3]IGF-I and IGF-I, we acid-trapped folding intermediates and products for inclusion in a kinetic analysis of refolding. In addition to non-native intermediates, three native-like intermediates were identified, that appear to have a major role in the in vitro refolding pathway of Long-[Arg3]IGF-I; a single disulfide Cys18-Cys61 intermediate, an intermediate with Cys18-Cys61 and Cys6 Cys48 disulfide bonds and another with Cys18-Cys61 and Cys47-Cys52 disulfide bonds. Furthermore, from our kinetic analysis we propose that the Cys18-Cys61, Cys6-Cys48 intermediate forms the native structure, not by the direct formation of the last (Cys47-Cys52) disulfide bond, but by rearrangement via the Cys18 Cys61 intermediate and a productive Cys18-Cys61, Cys47-Cys52 intermediate. In this pathway, the last disulfide bond to form involves Cys6 and Cys48. Finally, we apply this pathway to IGF-I and conclude that the divergence in the in vitro folding pathway of IGF-I is caused by non-native interactions involving Glu3 that stabilize the alternative structure. PMID- 9951524 TI - Demonstration of efficient trichloroethylene biodegradation in a hollow-fiber membrane bioreactor. AB - Rapid cometabolism of trichloroethylene (TCE) by pure cultures of Methylosinus trichosporium OB3b PP358 was demonstrated in a two-stage hollow-fiber membrane bioreactor over the course of 3 weeks. PP358 was grown in a continuous-flow chemostat and circulated through the shell of a hollow-fiber membrane module (HFMM), while TCE contaminated water (160 to 1450 micrograms/L) was pumped through the fiber lumen (fiber interior). In parallel-flow HFMM biological experiments, 82% to 89% of the influent TCE was removed from the lumen (5.1-min residence time) with 99% of the transferred TCE undergoing biodegradation. Biological experiments in a larger capacity baffled radial-flow HFMM resulted in 66% to 99% TCE transferred and 93% to 96% TCE biodegradation at lumen residence times of between 1.5 and 3.7 min. Biodegradation was maintained throughout the experiments at pseudo-first-order biodegradation rate constants of 0.41 to 2.8 L/mg TSS/day. Best-fit computer modeling of the baffled radial-flow biological process estimated mass transfer coefficients as large as 2.7 x 10(-2) cm/min. The computer model was also shown to simulate the experimental results quite well. PMID- 9951526 TI - Protein refolding in predominantly organic media markedly enhanced by common salts. AB - The refolding/reoxidation of unfolded/reduced hen egg-white lysozyme was investigated in a variety of predominantly nonaqueous media consisting of protein dissolving organic solvents and water. It was discovered that LiCl and other common salts dramatically (up to more than 100-fold) increased the refolding yield of lysozyme in such nonaqueous systems, while reducing it in water. The mechanism of this surprising phenomenon appears to involve salt-induced suppression of nonspecific lysozyme aggregation during refolding due to an enhanced protein solubility. PMID- 9951527 TI - Incorporating qualitative knowledge in enzyme kinetic models using fuzzy logic. AB - Modeling of metabolic pathway dynamics requires detailed kinetic equations at the enzyme level. In particular, the kinetic equations must account for metabolite effectors that contribute significantly to the pathway regulation in vivo. Unfortunately, most kinetic rate laws available in the literature do not consider all the effectors simultaneously, and much kinetic information exists in a qualitative or semiquantitative form. In this article, we present a strategy to incorporate such information into the kinetic equation. This strategy uses fuzzy logic-based factors to modify algebraic rate laws that account for partial kinetic characteristics. The parameters introduced by the fuzzy factors are then optimized by use of a hybrid of simplex and genetic algorithms. The resulting model provides a flexible form that can simulate various kinetic behaviors. Such kinetic models are suitable for pathway modeling without complete enzyme mechanisms. Three enzymes in Escherichia coli central metabolism are used as examples: phosphoenolpyruvate carboxylase; phosphoenolpyruvate carboxykinase; and pyruvate kinase I. Results show that, with fuzzy logic-augmented models, the kinetic data can be much better described. In particular, complex behavior, such as allosteric inhibition, can be captured using fuzzy rules. The resulting models, even though they do not provide additional physical meaning in enzyme mechanisms, allow the model to incorporate semiquantitative information in metabolic pathway models. PMID- 9951528 TI - Stabilization of a proteolytically sensitive cytoplasmic recombinant protein during transition to downstream processing. AB - The influence of aeration and glucose feeding on the stability of recombinant protein A in Escherichia coli during the transition period from a fed-batch cultivation to downstream processing was studied. Neither interruption of the feeding under aerobic conditions nor anaerobic conditions in presence of glucose could stabilize protein A completely and the intracellular ATP pool did not decrease to less than 0.75-1 mM by this treatment. On the other hand, the absence of both oxygen and glucose resulted in a decrease of the ATP pool to less than 0.5 mM and almost complete stabilization of protein A. The decrease of ATP was more severe when sulfite was used instead of nitrogen gas to create anaerobic conditions in presence of glucose. This also resulted in nearly complete stabilization of protein A, which might be explained by an inhibiting effect of sodium sulfite on fermentation. Therefore, protein stabilization and decrease of the ATP pool were correlated in experiments in vivo. The concentrations of ADP and AMP increased during starvation and may also play a role in stabilization of the protein in vivo. ATP may be a limiting factor of proteolysis also during further steps of downstream processing. Its concentration decreases by 80-90% during harvesting and centrifugation of biomass and even further during disruption of cells. However, neither addition nor regeneration of ATP in cell disintegrate was enough to restore degradation of protein A, indicating that an additional factor limits proteolysis in vitro. PMID- 9951529 TI - [Dietary iron absorption. Role of vitamin A]. AB - Iron and vitamin A are essential nutrients for human growing, development and maintenance. Deficiency of these elements is a public health problem especially in developing countries. Recently it has been reported that vitamin A has a favorable effect on iron absorption, probably due to the formation of an iron vitamin A chelate, that keeps iron soluble and available for absorption. This vitamin establishes a competence with other iron-binding molecules (phytates and polyphenols) that are not absorbed and render insoluble iron. Food enrichment programs with both iron and vitamin A, will provide these two essential nutrients and also an enhanced iron absorption even from diets with a high content of inhibitors. PMID- 9951530 TI - [Estimating height and body weight from knee height and mid arm circumference in children 9 to 14 years old]. AB - Some individuals with functional limitations or in some clinical or field areas have troubles to get stature and body weight measurement done. It does exist the alternative of estimating these variables from measurements of body segments like knee height (KH) and mid arm circumference (MAC). Of a sample of 113 healthy Venezuelan children, both sexes, 9 to 14 years of age, equations suggested by Ross Laboratories for estimating stature and body weight were applied. It was concluded that the need for an adjustment was evident which done using multiple regression analysis. This allowed us to generate estimated stature an weight by KH and MAC tables, for Venezuelan children. PMID- 9951531 TI - [Anthropometric assessment and school achievement in school-age children from high school in Valparaiso, Chile]. AB - The purpose of this study was to determine the interrelationship between nutritional status and scholastic achievement (SA). The total population included 1,488 high school students from Valparaiso, City, V Region of Chile. A representative sample of 165 school-age children was chosen from public schools in which the Improvement Education Quality Program (MECE) from the Ministry of Education of Chile was tried. Socioeconomic status (SES) was measured by means of the Graffar's modified method. Nutritional status was assessed through anthropometric measurements of weight (W), height (T), head circumference (HC), arm circumference (AC) and triceps skindfold (TS). SA was determined by a language (SAL) and mathematics (SAM) test. Statistical analysis included analysis of variance, correlation multiple regression and chi-square. Results showed that HC is the anthropometric parameter with the greatest explanatory power in SA variance, in high school graduates (r2 = 0.7697), both SAL (r2 = 0.9258) and SAM (r2 = 0.5268), with a RR = 1.97. In this respect, 75% of school children with Z HC values below median obtained a low percentage of achievement in the SA test. Considering that HC is a direct indicator of nutritional background and indirect indicator of brain development, these findings increase the knowledge in this area and reveal the need to carry out further research related to the interrelationship SA-brain development. PMID- 9951532 TI - [Differences in percent composition of long chain polyunsaturated fatty acids in maternal-fetal erythrocytes in term and preterm infants]. AB - The content and distribution of long-chain polyunsaturated fatty acids (LCP) of maternal-fetal erythrocytes phospholipids was investigated. Blood samples from healthy pregnant women were taken from maternal veins and umbilical cord at spontaneous delivery time. Two groups were segregated and compared in terms of fetuses gestational age: preterm delivery (32-34 weeks) and term delivery (40 weeks). The results showed that in erythrocytes of term newborn the content of LCP omega 6 and omega 3; particularly 20:4w6 (ARA) and 22:6w3 (DHA), were found to be statistically higher than their respective mother. However, in preterm newborns, all LCP from phospholipids erythrocytes were found to be statistically lower than in their mother. Comparing the content of ARA and DHA between the newborn groups, it observed that only DHA was decreased in preterm group. Women who delivered premature babies showed a blood ratio ARA/DHA higher than those who delivered term-babies. From this study and considering previous information it can be suggested that a high content of ARA and ARA/DHA ratio in maternal and fetal erythrocytes may considered an early risk signal of preterm delivery. PMID- 9951533 TI - [The liver as a source of essential long chain polyunsaturated fatty acids for postnatal brain development in the rat]. AB - We address here the issue concerning the origin of essential long chain polyunsaturated fatty acids (LC-PUFA) needed for early postnatal brain development. Normal newborn rats 1, 5, 10 and 20 day-old were decapitated, immediately after, the livers were processed to obtain the microsomal fraction and its delta 6 fatty acid desaturase activity and fatty acid composition were determined. Samples of plasma, whole homogenized brain hemispheres and milk contained in the gastric cavity of the suckling rats, were analyzed to obtained their fatty acid composition. We fond that the rat neonate has a very low delta 6 desaturase activity in liver microsomes as compared with the adult. In contrast, there is a considerable quantity of DHA an AA in the milk, liver microsomes, plasma lipids and brain. In conclusion, we propose that brain DHA and AA cannot be derived substantially through liver synthesis, but through the availability of these preformed fatty acids in the milk. These fatty acids are concentrated in liver microsomes and then secreted into plasma lipid pool to reach finally to brain structures. PMID- 9951534 TI - [Consumption of foods prepared with corn, wheat and rice and its relationship to gastric cancer incidence in Mexico]. AB - To assess the consumption of food prepared with corn, wheat or rice, in relation to the risk of developing gastric cancer (GC). We analyzed information about cereal consumption using data from a study of diet and GC for which 220 histologically confirmed incident GC cases and 752 population-based controls, were recruited. All subjects were interviewed using a food frequency questionnaire in which the consumption of 11 foods prepared with corn, wheat or rice, 54 additional food items and 4 alcoholic beverages was assessed. Adjusting by age, gender and total caloric intake, the results did not show an increased risk for gastric cancer incidence in regard to the consumption of foods prepared with corn (O.R. q4 vs. q1 = 0.97 C.I. 95% 0.58-1.63), wheat (O.R. q4 vs. q1 = 1.07 C.I. 95% 0.62-1.84) or rice (O.R. q4 vs. q1 = 1.36 C.I. 95% 0.96-1.90). These results remained similar after stratifying by histological type of GC (i.e. intestinal vs. diffuse). Our results do not lend support to the hypothesis that the consumption of foods prepared with corn, wheat or rice increase the risk of being diagnosed with gastric cancer. PMID- 9951535 TI - Evaluation of the composition of the regional diet in Sonora, Mexico: incidence of colon cancer. AB - Diet is responsible for about one third of the cancers. Dietary fiber, energy intake, fat and consumption of fruits and vegetables play an important role in different cancers. The regional Mexican diet is characterized as being high in dietary fiber, high in fat and energy but very low in fruits and vegetables. The diet is high in insoluble fiber and phytate. The objective of this study was to evaluate the composition of the regional diet and relate this composition to the incidence of colon cancer in the northern region of Mexico. Two traditional diets, one higher in fruits and vegetables, but both high in fat and dietary fiber were evaluated. A mathematical expression showed the typical regional diet to be low in antioxidant nutrients, even though an earlier study showed it to have a tendency to protect against colon cancer. During the years of 1991-1995, Sonora, Mexico reported about 20 cases/ 100,000 inhabitants of colon cancer. This incidence is low compared to other regions and high dietary fiber is thought to be responsible. If antioxidant nutrient intake was elevated, possibly a greater protection could be achieved. PMID- 9951536 TI - [Breastfeeding in shantytowns: an educational program through home visits]. AB - This is a study of breastfeeding length, with and without a community educational program. It was done through home visits to 125 women residing in Vila Marianais shantytowns in the city of Sao Paulo. It was found that breastfeeding lasts an average of more than 6 months after the educational intervention. When comparing the group that received education with the one that didnit, it was observed that in the former the percentage of children breastfed for 6 months or longer was 64%, while in the control group it was 17% (p < 0.001). This shows a significant increase in the number of mothers who nursed their children after an educational program promoting breastfeeding. PMID- 9951537 TI - [WinDiet. Support decision system for the assessment of nutritional status and diet prescription]. AB - A "Sistema de Apoio a Decisao para Avaliacao do Estado Nutricional e Prescricao de Dietas" called "WinDiet" was developed. The system was developed on a computer compatible to IBM-PC standard. For system processing procedures through the computer, that is, interpretation, compilation, table generation en others, it was selected the Delphi version 1.0 software, from Borland International, for its using facilities, data basis accomplishment, communication environment and mainly an ample availability of mathematic, impression and programming resources besides allowing for all the programming operations to be accomplished on Windows environment. Knowing the procedures for nutritional evaluation and diet prescription was possible by consulting to text books, periodicals and the area experts. This system allows for individual nutritional assessment applying the anthropometric methods such as weight, height, skinfold thickness measurings, the lab methods such as albumin, transferrin, height/creatinin index and others, the dietary methods by food consumption recall, and the clinical methods that give emphasis to pathological antecedents and indicative sings of nutritional status. The software also turns possible to prescribe and calculate diets from recommendation besides having an actual data basis which may be changed or modified. Yet it maintains the individual description from all evaluation and menus, emitting its complete reports. It was verified that it reduce significantly the working time and increase the precision of estimate and nutritional diagnosis. Thus, the WinDiet may be used in nutritionist's offices, ambulatories, hospitals as well as on nutritional researches and education. PMID- 9951538 TI - Quality control of beer hopped with reduced isomerised products. AB - The traditional method for measuring bitterness in beer by UV absorbance (ASBC 9.6) remains a viable quality control method for normally hopped beer. However, after reduction of isoalpha acids specific absorptivity of active components change and HPLC analysis shows to be a reliable method for quality control of these materials. This work is intended to adapt mathematically the ASBC (American Society of Brewing Chemist) spectrophotometrical method and to evaluate an HPLC method to control the composition of different commercial reduced isomerised products added to unhopped wort and partially kettle hopped beer. The results we obtained showed that the HPLC method is reliable for quality control of reduced isomerised products and that the traditional spectrophotometrical method is viable for quality control of beer, also using reduced isomerised products as far as an adequate factor is used. PMID- 9951539 TI - [Co-crystallization of cucumber concentrate (Cucumis sativa L.)]. AB - A sucrose syrup of 70 degrees Brix was concentrated until a concentration greater than 95 degrees Brix was attained. It was studied the effect of concentration (20, 25 and 35 degrees Brix) on the physical properties of the cucumber (Cucumis sativa L.) granules. Moisture content, solubility, and density were determined. The best results were found for the concentrated at 30 degrees Brix. Lemon juice was added to the concentrated to decrease pH from 5.5 to 4.0 to improve flavor and to avoid growth of molds and yeast. No significant differences in the higroscopicity were found between both pH (s). Sensory evaluation shows that 30 judges of 45 preferred the sample made with the co-crystallizate containing lemon juice. PMID- 9951540 TI - [Nutritional characteristics of a cookie formulated with bovine blood plasma as a main source of protein]. AB - The nutritional characteristics of a cookie formulated with bovine plasma as main protein source was evaluated. Bovine plasma was mixed with wheat flour, sugar or salt, condiments and vegetable oil. The mix was placed in trays and baking at 120 degrees C during 1 hour. Moisture, fat, protein, carbohydrate, metabolizable energy, ash, iron, essential amino acids, essential fatty acids, apparent digestibility, protein efficiency ratio, acceptability and tolerance of the final product were determined. Results indicated that 100 g of the cookie have 5 g of moisture, 16 g of fat, 16 g of protein, 61.4 g of carbohydrate, 408.2 Kcal of metabolizable energy, 1.59 g of ash, 1.9 mg of iron and 6.59 g of essential amino acids. Polyunsaturated fatty acids are in higher amount than saturated fatty acids. Results also indicated that 100 g of cookie provide at least 20% of the daily energy requirements, 24% of the iron and between 30 to 50% of the daily protein requirements for children at school age. Its digestibility and PER, tested in rats, were of 88.4% and 2.32 respectively. Acceptability and tolerance, both tested in children, were 97% and 100% respectively. The protein cookie could be included as a protein and energy supply in school meals. PMID- 9951541 TI - Vitamin C in Barbados cherry Malpighia glabra L. pulp submitted to processing and to different forms of storage. AB - Ripe fruits of Barbados cherry Malpighia glabra L. proceeding from the fruit growing section of Iguatemi Experimental Farm of Universidade Estadual de Maringa (PR), were triturated in a liquefier and hulled in a stainless steel sieve with 25 mesh. The bagasse (seeds and hull) was discarded and the vitamin C content was immediately determined, which was 1.79 g by 100 g of pulp. After that, the integral pulp was packed in glass flasks and submitted to the exhaustion and pasteurization processes and then hermetically closed. After the heat treatment the vitamin C content was 1.54 g by 100 g of pulp. The sealed flasks of Barbados cherry pulp, with and without the aluminum foil protection, were stored for 40 days. The first portion was kept at room temperature, the second in a refrigerator (1 degree C), and the third in a freezer (-18 degrees C). The vitamin C content analysis were realized on the 5th, 10th, 15th, 20th, 30th and 40th day. For the flasks stored without the aluminum foil protection, there was a loss of 22.08%, 7.79% and 1.30% and with aluminum foil the loss was of 10.40%, 3.90% and 1.30% for the storage at room, refrigeration and freezing temperatures, respectively. The results show that freezing method is the best form of vitamin C preservation. PMID- 9951542 TI - [Contents of various nutrients, minerals and seasonal fluctuations in Porphyra columbina, an edible marine algae from the Argentine Patagonian++ coast]. AB - Porphyra columbina (Rodophyta Bangiales), one of the most important edible seaweeds, grows abundantly in the southern Argentine coast. Their mineral content and seasonal fluctuations were determined because there is no national data about their nutritional value. Samples were collected from April 1993 to February 1994 from Golfo San Jorge (30 Km South of Comodoro Rivadavia). Algae were washed with sea water and dried at room temperature (20-2 degrees C) for 24 hs, following the local processing procedure. Moisture and ashes were determined according to A.O.A.C. After mineralization with nitric acid sodium and potassium were determined by flame photometry; calcium, magnesium and iron by atomic absorption spectrophotometry (AAS); and phosphorus by Gomori's method. The results, expressed per 100 g dry algae showed the following values: moisture content: 7.03 to 11.00 g/100 g; ashes: 16.18 to 22.70 g/100 g; sodium: 3.18 to 6.41 g/100 g; potassium 1.24 to 1.96 g/100 g; magnesium: 600 to 836 mg/100 g; phosphorus: 78 to 276 mg/100 g; calcium: 63 to 108 mg/100 g and iron: 3.9 to 26.4 mg/100 g. The results of composition of algae as manufactured in the region showed important seasonal differences, with the highest values of ashes, sodium, potassium and magnesium in winter season (June and July). PMID- 9951543 TI - [Vitamins and minerals in oil canned yellow fin tuna (Thunnus albacares), from the Mexican Pacific]. AB - Tuna is one of the most consumed sea food in Mexico due to it's abundance and low cost. The micronutrient content was evaluated in yellow fin tuna (Thunnus albacares) canned in vegetable oil (7 samples with 5 repetitions). Tuna proceed from different areas in the coast of the Pacific, Baja California Sur (L1), Mazatlan (L2) and Colima (L3). The approximate chemical analysis was carried out by the methods of AOAC; minerals (Ca, P, Mg, Na, K, Fe, Zn, Cu, Cd, Cr an Pb) by atomic absorption spectrophotometry and vitamins by HPLC. The percentage of moisture was among 65-75%, crude protein (12.6-16.4%) and ether extract, the fraction with most variation among locations, was (7.1-15.9%). Niacin was the most abundant vitamin (4.8-16.5 mg/100 g); mean Vitamin A (UI/100 g) in L1 and L2 was similar (36.5 and 36.2), and higher in L3 (42.0). The most abundant minerals were Na (136-552 mg/100 g) and K (78-221 mg/100 g), from this, the widest range of Na and K were found in L1, while L2 was for P. Ca (mg/100 g) showed different mean values between L1 (6.9) and L2 (12.7) and in L3 the range was extensive (3.4 21.8). Zn was low in L2 (0.2-0.4 mg/100 g) and higher in L3 (0.54-0.70 mg/100 g). Mg and Cu were the mineral with the narrowest range and with mean values similar among locations. Pb, Cd and Cr were not detected. The mineral with the highest variation among locations were Ca, Na and Zn; and among commercial brands were Fe, Na, K and Ca. Vitamin A, Cu and Mg showed the least variation between locations. It is concluded that the yellow fin tuna provides important amounts of ether extract, Na, K, P and niacin. PMID- 9951545 TI - Control of gene expression in Trypanosomatidae. AB - The study of mechanisms which control gene expression in trypanosomatids has developed at an increasing rate since 1989 when the first successful DNA transfection experiments were reported. Using primarily Trypanosoma brucei as a model, several groups have begun to elucidate the basic control mechanisms and to define the cellular factors involved in mRNA transcription, processing and translation in these parasites. This review focuses on the most recent studies regarding a subset of genes that are expressed differentially during the life cycle of three groups of parasites. In addition to T. brucei, I will address studies on gene regulation in a few species of Leishmania and the results obtained by a much more limited group of laboratories studying gene expression in Trypanosoma cruzi. It is becoming evident that the regulatory strategies chosen by different species of trypanosomatids are not similar, and that for these very successful parasites it is probably advantageous to employ multiple mechanisms simultaneously. In addition, with the increasing numbers of parasite genes that have now been submitted to molecular dissection, it is also becoming evident that, among the various strategies for gene expression control, there is a predominance of regulatory pathways acting at the post-transcriptional level. PMID- 9951546 TI - Food, mood and health: a neurobiologic outlook. AB - Hippocrates was the first to suggest the healing power of food; however, it was not until the medieval ages that food was considered a tool to modify temperament and mood, although scientific methods as we know them today were not in use at the time. Modern scientific methods in neuroscience began to emerge much later, leading investigators to examine the role of diet in health, including mental wellbeing, with greater precision. This review shows how short- and long-term forced dietary interventions bring about changes in brain structure, chemistry, and physiology, leading to altered animal behavior. Examples will be presented to show how diets alter brain chemistry, behavior, and the action of neuroactive drugs. Most humans and most animal species examined in a controlled setting exhibit a fairly reproducible pattern of what and how they eat. Recent data suggest that these patterns may be under the neurochemical and hormonal control of the organisms themselves. Other data show that in many instances food may be used unconsciously to regulate mood by seemingly normal subjects as well as those undergoing drug withdrawal or experiencing seasonal affective disorders and obesity-related social withdrawal. We will discuss specific examples that illustrate that manipulation of dietary preference is actually an attempt to correct neurochemical make-up. PMID- 9951547 TI - Catabolism of Ap4A and Ap5A by rat brain synaptosomes. AB - Adenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) and adenosine 5',5"'-P1,P5 pentaphosphate (Ap5A) are stored in and released from rat brain synaptic terminals. In the present study we investigated the hydrolysis of dinucleotides (Ap4A and Ap5A) in synaptosomes from the cerebral cortex of adult rats. Ap4A and Ap5A, but not Ap3A, were hydrolyzed at pH 7.5 in the presence of 20 mM Tris/HCl, 2.0 mM MgCl2, 10 mM glucose and 225 mM sucrose at 37 degrees C. The disappearance of the substrates measured by FPLC on a mono-Q HR column was both time and protein dependent. Since synaptosome integrity was at least 90% at the end of the assay, hydrolysis probably occurred by the action of an ecto-enzyme. Extracellular actions of adenine dinucleotides at central nervous system terminate due to the existence of ecto-nucleotidases which specifically cleave these dinucleotides. These enzymes in association with an ATP diphosphohydrolase and a 5'-nucleotidase are able to promote the complete hydrolysis of dinucleotides to adenosine in the synaptic cleft. PMID- 9951548 TI - Erythrocyte glucose-6-phosphate dehydrogenase activity assay and affinity for its substrate under "physiological" conditions. AB - Glucose-6-phosphate dehydrogenase (G6PD) activity and the affinity for its substrate glucose-6-phosphate were investigated under conditions similar to the physiological environment in terms of ionic strength (I: 0.188), cation concentration, pH 7.34, and temperature (37 degrees C). A 12.4, 10.4 and 21.4% decrease was observed in G6PD B, G6PD A+ and G6PD A- activities, respectively. A Km increase of 95.1, 94.4 and 95.4% was observed in G6PD B, G6PD A+ and G6PD A-, respectively, leading to a marked decrease in affinity. In conclusion, the observation of the reduced activity and affinity for its natural substrate reflects the actual pentose pathway rate. It also suggests a much lower NADPH generation, which is crucial mostly in G6PD-deficient individuals, whose NADPH availability is poor. PMID- 9951549 TI - Effect of all-trans retinoic acid on newly diagnosed acute promyelocytic leukemia patients: results of a Brazilian center. AB - Thirty-seven patients with acute promyelocytic leukemia (APL) were treated with all-trans retinoic acid (ATRA). Patients received 45 mg m-2 day-1 po of ATRA until complete remission (CR) was achieved, defined as: a) presence of less than 5% blasts in the bone marrow, with b) white blood cells > 10(3)/mm3, c) platelets > 10(5)/mm3 and d) hemoglobin concentration > 8 g/dl, with no blood or platelet transfusions. Thirty-one (83.7%) patients achieved CR by day 50, and 75% of these before day 30. Correction of the coagulopathy, achieved between days 2 and 10 (mean, 3 days), was the first evidence of response to treatment. Only one patient had been previously treated with chemotherapy and three had the microgranular variant M3 form. Dryness of skin and mucosae was the most common side effect observed in 82% of the patients. Thrombosis, hepatotoxicity and retinoid acid syndrome (RAS) were observed in 7 (19%), 6 (16%) and 4 (11%) patients, respectively. Thirteen (35%) patients had to be submitted to chemotherapy due to hyperleukocytosis (above 40 x 10(3)/mm3) and six of these presented with new signs of coagulopathy after chemotherapy. Four (11%) patients died secondarily to intracerebral hemorrhage (IH) and two (5.4%) dropped out of the protocol due to severe ATRA side effects (one RAS and one hepatotoxicity). RAS and IH were related strictly to hyperleukocytosis. The reduced use of platelets and fresh frozen plasma probably lowered the total cost of treatment. We conclude that ATRA is an effective agent for inducing complete remission in APL patients. PMID- 9951550 TI - Low levels of sex hormone-binding globulin and hyperproinsulinemia as markers of increased pancreatic beta-cell demand in men. AB - Low levels of sex hormone-binding globulin (SHBG) are considered to be an indirect index of hyperinsulinemia, predicting the later onset of diabetes mellitus type 2. In the insulin resistance state and in the presence of an increased pancreatic beta-cell demand (e.g. obesity) both absolute and relative increases in proinsulin secretion occur. In the present study we investigated the correlation between SHBG and pancreatic beta-cell secretion in men with different body compositions. Eighteen young men (30.0 +/- 2.4 years) with normal glucose tolerance and body mass indexes (BMI) ranging from 22.6 to 43.2 kg/m2 were submitted to an oral glucose tolerance test (75 g) and baseline and 120-min blood samples were used to determine insulin, proinsulin and C-peptide by specific immunoassays. Baseline SHBG values were significantly correlated with baseline insulin (r = -0.58, P < 0.05), proinsulin (r = -0.47, P < 0.05), C-peptide (r = 0.55, P < 0.05) and also with proinsulin at 120 min after glucose load (r = 0.58, P < 0.05). Stepwise regression analysis revealed that proinsulin values at 120 min were the strongest predictor of SHBG (r = -0.58, P < 0.05). When subjects were divided into obese (BMI > 28 kg/m2, N = 8) and nonobese (BMI < or = 25 kg/m2, N = 10) groups, significantly lower levels of SHBG were found in the obese subjects. The obese group had significantly higher baseline proinsulin, C-peptide and 120-min proinsulin and insulin levels. For the first time using a specific assay for insulin determination, a strong inverse correlation between insulinemia and SHBG levels was confirmed. The finding of a strong negative correlation between SHBG levels and pancreatic beta-cell secretion, mainly for the 120-min post-glucose load proinsulin levels, reinforces the concept that low SHBG levels are a suitable marker of increased pancreatic beta-cell demand. PMID- 9951551 TI - Incidence of type 1 diabetes mellitus in Passo Fundo, RS, Brazil. AB - To establish the incidence of type 1 diabetes among children (infants to 14 years of age) in the city of Passo Fundo, Rio Grande do Sul, Brazil (population under 15 years = 50,098), during the period of January to December 1996, a retrospective and prospective population-based registry was established, using physician reports of newly diagnosed patients under 15 years of age with type 1 diabetes as the primary source of case identification. Primary and nursery schools and a general call through the media (newspapers, radio and television) was the secondary source. Data were calculated according to the methods recommended by the WHO (1990). Six new cases were identified. Case ascertainment was estimated at 100%. The incidence of type 1 diabetes in the year 1996 was 12/100,000 inhabitants. These data indicate that the incidence of childhood type 1 diabetes in a subtropical region in the Southern part of Brazil was similar to that observed in developed countries throughout the world. The inability to demonstrate the North-South gradient is probably due to the European origin of inhabitants of the city. PMID- 9951552 TI - Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts. AB - Human subjects with active vulgar vitiligo do not respond well to autologous dermo-epidermal minigrafting. Eighteen subjects were treated with the alpha melanocyte-stimulating hormone (alpha-MSH) synthetic analogue [Nle4, D-Phe7] alpha-MSH. The hormone (50 microliters, 0.4 mM) was applied topically to 30-cm2 lesions in which 29-48 minigrafts had been made. The hormone did not improve the success of the minigrafting and no differences were observed in local or distant repigmentation in treated subjects as compared to the placebo group. Aliquots of 24-h urine concentrated by lyophilization irreversibly darkened toad skins, demonstrating the presence of the analogue. This is the first report of the transdermal delivery of a topically applied melanotropin in living human subjects. PMID- 9951553 TI - Monoassociation with Lactobacillus acidophilus UFV-H2b20 stimulates the immune defense mechanisms of germfree mice. AB - Probiotics are formulations containing live microorganisms or microbial stimulants that have some beneficial influence on the maintenance of a balanced intestinal microbiota and on the resistance to infections. The search for probiotics to be used in prevention or treatment of enteric infections, as an alternative to antibiotic therapy, has gained significant impulse in the last few years. Several studies have demonstrated the beneficial effects of lactic acid bacteria in controlling infection by intestinal pathogens and in boosting the host's nonspecific immune response. Here, we studied the use of Lactobacillus acidophilus UFV-H2b20, a lactic acid bacterium isolated from a human newborn from Vicosa, Minas Gerais, Brazil, as a probiotic. A suspension containing 10(8) cells of Lactobacillus acidophilus UFV-H2b20 was inoculated into groups of at least five conventional and germfree Swiss mice to determine its capacity to stimulate the host mononuclear phagocytic activity. We demonstrate that this strain can survive the stressing conditions of the intestinal tract in vivo. Moreover, the monoassociation of germfree mice with this strain for seven days improved the host's macrophage phagocytic capacity, as demonstrated by the clearance of a Gram negative bacterium inoculated intravenously. Monoassociated mice showed an undetectable number of circulating E. coli, while 0.1% of the original inoculum was still present in germfree animals. Mice treated with viable or heat-killed Lactobacillus acidophilus UFV-H2b20 presented similarly improved clearance capacity when compared with germfree controls. In addition, monoassociated mice had twice the amount of Kupffer cells, which are responsible for the clearance of circulating bacteria, compared to germfree controls. These results suggest that the L. acidophilus strain used here stimulates a nonspecific immune response and is a strong candidate to be used as a probiotic. PMID- 9951554 TI - Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules. AB - It has been shown that HLA class I molecules play a significant role in the regulation of the proliferation of T cells activated by mitogens and antigens. We evaluated the ability of mAb to a framework determinant of HLA class I molecules to regulate T cell proliferation and interferon gamma (IFN-gamma) production against leishmania, PPD, C. albicans and tetanus toxoid antigens in patients with tegumentary leishmaniasis and healthy subjects. The anti-major histocompatibility complex (MHC) mAb (W6/32) suppressed lymphocyte proliferation by 90% in cultures stimulated with alpha CD3, but the suppression was variable in cultures stimulated with leishmania antigen. This suppression ranged from 30-67% and was observed only in 5 of 11 patients. IFN-gamma production against leishmania antigen was also suppressed by anti-HLA class I mAb. In 3 patients IFN-gamma levels were suppressed by more than 60%, while in the other 2 cultures IFN-gamma levels were 36 and 10% lower than controls. The suppression by HLA class I mAb to the proliferative response in leishmaniasis patients and in healthy controls varied with the antigens and the patients or donors tested. To determine whether the suppression is directed at antigen presenting cells (APCs) or at the responding T cells, experiments with antigen-primed non-adherent cells, separately incubated with W6/32, were performed. Suppression of proliferation was only observed when the W6/32 mAb was added in the presence of T cells. These data provide evidence that a mAb directed at HLA class I framework determinants can suppress proliferation and cytokine secretion in response to several antigens. PMID- 9951555 TI - Trypanosoma cruzi: amastigote polymorphism defined by monoclonal antibodies. AB - We have raised monoclonal antibodies (mAbs) directed towards amastigote forms of Trypanosoma cruzi, and shown that mAbs ID9 and 4B9 are carbohydrate while mAb 4B5 activity is resistant to periodate oxidation of the antigen. Here we used an ELISA to quantitate and compare the expression of surface epitopes on fixed parasites among different parasite isolates. The expression of markers varied among T. cruzi amastigotes isolated from infected cells or after extracellular differentiation of trypomastigotes. Moreover, we also observed an extensive polymorphic expression of these epitopes among amastigotes derived from different strains and clones. For instance, mAb 2C2 strongly and evenly reacted with 9 strains and clones (G, Y, CL, Tulahuen, MD, and F, and clones Sylvio X-10/4, D11, and CL.B), with absorbance at 492 nm (A492 nm) from 0.6 to 0.8. By contrast, mAb 4B5 had a higher expression in Tulahuen amastigotes (around 0.9 at 492 nm) whereas its reactivity with amastigotes from clones CL.B, Sylvio X-10/4 and D11 was much lower (around 0.4). mAb 1D9 displayed an interesting pattern of reactivity with amastigotes of the different strains and clones (A492 nm of G > D11 > or = Sylvio X-10/4 = MD > Tulahuen = F = Y > CL > CL.B). Finally, we observed that mAb 4B9 had the lowest reaction with the parasites studied, with higher values of A492 nm with Y strain (around 0.6) and lower values with Tulahuen, F and CL.B strains (around 0.2). Immunoblotting analysis also showed extensive variations among amastigotes of the various parasite isolates and mAbs 4B9, 1D9 and 4B5 revealed significant differences in expression between clones and parental strains. These data describe a previously uncharacterized polymorphism of T. cruzi amastigote surface components. PMID- 9951556 TI - Cytotoxic activity of BCG-activated macrophages against L929 tumor cells is nitric oxide-dependent. AB - The tumoricidal activity of activated macrophages has been attributed largely to the release of tumor necrosis factor (TNF), or to the production of reactive oxygen or nitrogen intermediates. The L929 tumor cell line (a murine fibroblast like cell) when treated with actinomycin D (ActD) has been used to measure TNF alpha cytotoxicity. In the present study, we determined the cytotoxic activity of BCG-activated peritoneal macrophages against ActD-untreated L929 tumor cells. Furthermore, we measured the production of hydrogen peroxide (H2O2), nitric oxide (NO) and TNF by macrophages cultured in the presence or absence of L929 cells. As expected, BCG-activated macrophages produced significant amounts of H2O2 (16.0 +/ 3.0 microM), TNF (512 U/ml) and NO (71.5 +/- 3.2 microM). TNF (256 U/ml) and NO (78.9 +/- 9.7 microM) production was unchanged in co-cultures of L929 cells with BCG-activated macrophages but H2O2 production was totally inhibited. The cytotoxic activity was dependent on NO release since L-NAME (2.5, 5.0 and 10 mM), which blocks NO synthase, inhibited the killing of L929 cells. Addition of anti TNF (20 micrograms/ml) antibodies to the cultures did not affect the tumoricidal activity of macrophages. Our results indicate that macrophage-mediated killing of L929 cells is largely dependent on NO production but independent of H2O2 or TNF release. PMID- 9951557 TI - Role of angiotensin II and vasopressin receptors within the supraoptic nucleus in water and sodium intake induced by the injection of angiotensin II into the medial septal area. AB - In this study we investigated the effects of the injection into the supraoptic nucleus (SON) of non-peptide AT1- and AT2-angiotensin II (ANG II) receptor antagonists, DuP753 and PD123319, as well as of the arginine-vasopressin (AVP) receptor antagonist d(CH2)5-Tyr(Me)-AVP, on water and 3% NaCl intake induced by the injection of ANG II into the medial septal area (MSA). The effects on water or 3% NaCl intake were assessed in 30-h water-deprived or in 20-h water-deprived furosemide-treated adult male rats, respectively. The drugs were injected in 0.5 microliter over 30-60 s. Controls were injected with a similar volume of 0.15 M NaCl. Antagonists were injected at doses of 20, 80 and 180 nmol. Water and sodium intake was measured over a 2-h period. Previous administration of the AT1 receptor antagonist DuP753 into the SON decreased water (65%, N = 10, P < 0.01) and sodium intake (81%, N = 8, P < 0.01) induced by the injection of ANG II (10 nmol) into the MSA. Neither of these responses was significantly changed by injection of the AT2-receptor antagonist PD123319 into the SON. On the other hand, while there was a decrease in water intake (45%, N = 9, P < 0.01), ANG II induced sodium intake was significantly increased (70%, N = 8, P < 0.01) following injection of the V1-type vasopressin antagonist d(CH2)5-Tyr(Me)-AVP into the SON. These results suggest that both AT1 and V1 receptors within the SON may be involved in water and sodium intake induced by the activation of ANG II receptors within the MSA. Furthermore, they do not support the involvement of MSA AT2 receptors in the mediation of these responses. PMID- 9951558 TI - Involvement of hippocampal NMDA receptors in retention of shuttle avoidance conditioning in rats. AB - The purpose of this research was to evaluate the role of hippocampal N-methyl-D aspartate (NMDA) receptors in acquisition and consolidation of memory during shuttle avoidance conditioning in rats. Adult male Wistar rats were surgically implanted with cannulae aimed at the CA1 area of the dorsal hippocampus. After recovery from surgery, animals were trained and tested in a shuttle avoidance apparatus (30 trials, 0.5-mA footshock, 24-h training-test interval). Immediately before or immediately after training, animals received a bilateral intrahippocampal 0.5-microliter infusion containing 5.0 microgram of the NMDA competitive receptor antagonist aminophosphonopentanoic acid (AP5) or vehicle (phosphate-buffered saline, pH 7.4). Infusion duration was 2 min per side. Pre training infusion of AP5 impaired retention test performance (mean +/- SEM number of conditioned responses (CRs) during retention test session was 16.47 +/- 1.78 in the vehicle group and 9.93 +/- 1.59 in the AP5 group; P < 0.05). Post-training infusion of AP5 did not affect retention (mean +/- SEM number of conditioned responses during retention test session was 18.46 +/- 1.94 in the vehicle group and 20.42 +/- 2.38 in the AP5 group; P > 0.10). This impairment could not be attributed to an effect on acquisition, motor activity or footshock sensitivity since AP5 affected neither training session performance measured by the number of CRs nor the number of intertrial crossings during the training session. These data suggest that NMDA receptors in the hippocampus are critical for retention of shuttle avoidance conditioning, in agreement with previous evidence showing a role of NMDA receptors in fear memory. PMID- 9951559 TI - Decreased gastric emptying and gastrointestinal and intestinal transits of liquid after complete spinal cord transection in awake rats. AB - We studied the effect of complete spinal cord transection (SCT) on gastric emptying (GE) and on gastrointestinal (GI) and intestinal transits of liquid in awake rats using the phenol red method. Male Wistar rats (N = 65) weighing 180 200 g were fasted for 24 h and complete SCT was performed between C7 and T1 vertebrae after a careful midline dorsal incision. GE and GI and intestinal transits were measured 15 min, 6 h or 24 h after recovery from anesthesia. A test meal (0.5 mg/ml phenol red in 5% glucose solution) was administered intragastrically (1.5 ml) and the animals were sacrificed by an i.v. thiopental overdose 10 min later to evaluate GE and GI transit. For intestinal transit measurements, 1 ml of the test meal was administered into the proximal duodenum through a cannula inserted into a gastric fistula. GE was inhibited (P < 0.05) by 34.3, 23.4 and 22.7%, respectively, at 15 min, 6 h and 24 h after SCT. GI transit was inhibited (P < 0.05) by 42.5, 19.8 and 18.4%, respectively, at 15 min, 6 h and 24 h after SCT. Intestinal transit was also inhibited (P < 0.05) by 48.8, 47.2 and 40.1%, respectively, at 15 min, 6 h and 24 h after SCT. Mean arterial pressure was significantly decreased (P < 0.05) by 48.5, 46.8 and 41.5%, respectively, at 15 min, 6 h and 24 h after SCT. In summary, our report describes a decreased GE and GI and intestinal transits in awake rats within the first 24 h after high SCT. PMID- 9951560 TI - Kindling and second messengers: an approach to the neurobiology of recurrence in bipolar disorder. AB - Since bipolar disorder is inherently a longitudinal illness characterized by recurrence and cycling of mood episodes, neurobiological theories involving kindlinglike phenomena appear to possess a certain explanatory power. An approach to understanding kindlinglike phenomena at the molecular level has been made possible by advances in research on second-messenger systems in the brain. The time frame of interest has shifted from the microseconds of presynaptic events to hours, days, months, and even years in the longer duration of events beyond the synapse--through second messengers, gene regulation, and synthesis of long-acting trophic factors. These complex interlocking systems may explain how environmental stress could interact over time with genetic vulnerability to produce illness. In its two sections, this paper will review an approach to understanding two major aspects of the neurobiology of bipolar disorder: kindling phenomena and second messenger mechanisms. We will suggest that these two fields of research together help explain the biology of recurrence. PMID- 9951561 TI - Oxytocin, vasopressin, and autism: is there a connection? AB - Autism is a poorly understood developmental disorder characterized by social impairment, communication deficits, and compulsive behavior. The authors review evidence from animal studies demonstrating that the nonapeptides, oxytocin and vasopressin, have unique effects on the normal expression of species-typical social behavior, communication, and rituals. Based on this evidence, they hypothesize that an abnormality in oxytocin or vasopressin neurotransmission may account for several features of autism. As autism appears to be a genetic disorder, mutations in the various peptide, peptide receptor, or lineage-specific developmental genes could lead to altered oxytocin or vasopressin neurotransmission. Many of these genes have been cloned and sequenced, and several polymorphisms have been identified. Recent gene targeting studies that alter expression of either the peptides or their receptors in the rodent brain partially support the autism hypothesis. While previous experience suggests caution in hypothesizing a cause or suggesting a treatment for autism, the available preclinical evidence with oxytocin and vasopressin recommends the need for clinical studies using gene scanning, pharmacological and neurobiological approaches. PMID- 9951562 TI - Whole blood serotonin and plasma beta-endorphin in autistic probands and their first-degree relatives. AB - BACKGROUND: Whole blood serotonin (5-HT) and C-terminally directed beta-endorphin protein immunoreactivity (C-ter-beta-EP-ir) are known to be elevated in autistic subjects and might be possible markers of genetic liability to autism. This study thus investigates the familial aggregation of 5-HT and of C-ter-beta-EP-ir levels in first degree relatives of autistic probands. METHODS: In a sample of 62 autistic subjects and 122 of their first-degree relatives, compared to age and sex-matched controls, we measured 5-HT by radioenzymology and C-ter-beta-EP-ir by radioimmunoassay. RESULTS: We confirm the previously reported familiality of hyperserotoninemia in autism as mothers (51%), fathers (45%) and siblings (87%) have elevated levels of 5-HT, and we reveal presence of elevated levels of C-ter beta-EP-ir in mothers (53%) of autistic subjects. CONCLUSIONS: Familial aggregation of quantitative variables, such as concentration of neurotransmitters, within unaffected relative could serve as an intermediate phenotype and might thus help the search of genetic susceptibility factors in autism. PMID- 9951563 TI - Effect of long-term administration of antidepressant treatments on serotonin release in brain regions involved in obsessive-compulsive disorder. AB - BACKGROUND: Among all antidepressant treatments, including electroconvulsive shock (ECS) therapy and monoamine oxidase inhibitors (MAOIs), only the selective serotonin (5-HT) reuptake inhibitors (SSRIs) exert a clear therapeutic effect in obsessive-compulsive disorder (OCD). An 8-week, but not a 3-week treatment with the SSRI paroxetine results in an increased electrically evoked [3H]5-HT release and a desensitization of 5-HT autoreceptors in the guinea pig orbitofrontal cortex, a brain region implicated in OCD. METHODS: In the present study, the effect of long-term treatment with the SSRI fluoxetine, ECS, and the reversible type A MAOI moclobemide was investigated on evoked [3H]5-HT release from preloaded guinea pig brain slices prepared from the hypothalamus, cingulate cortex, and orbitofrontal cortex. RESULTS: Fluoxetine treatment yielded an enhanced [3H]5-HT release in the three brain areas, but a desensitization of the 5-HT autoreceptor only in the hypothalamus and orbitofrontal cortex. ECS treatment did not result in any alteration of the electrically evoked [3H]5-HT release or of 5-HT autoreceptor sensitivity in any of the brain regions. Moclobemide increased [3H]5-HT release only in the orbitofrontal cortex without any alteration in the 5-HT autoreceptor sensitivity. CONCLUSIONS: These findings indicate that only treatments effective in OCD have the capacity to desensitize the terminal 5-HT autoreceptor in the orbitofrontal cortex. PMID- 9951564 TI - Chronic fluoxetine administration increases the serotonin N-acetyltransferase messenger RNA content in rat hippocampus. AB - BACKGROUND: It has been proposed that up-regulation of cyclic adenosine monophosphate response element binding protein is a common action of chronic antidepressant treatments that may regulate specific target genes in the hippocampus. We hypothesized that the serotonin N-acetyltransferase (AA-NAT; EC 2.3.1.87) gene is one such target. AA-NAT leads to formation of N-acetylserotonin from serotonin, and in the pineal gland, to melatonin synthesis. We investigated whether hippocampal AA-NAT expression can be modified by chronic administration of fluoxetine to rats. METHODS: Male Brown-Norway rats were administered 5 mg/kg fluoxetine or its vehicle either once (acute) or once daily for 21 days (chronic). They were sacrificed 18 hours after the last injection, and their hippocampi were processed for a quantitative reverse-transcription/polymerase chain reaction assay of AA-NAT and cyclophilin (cyc) messenger (m)RNAs. The results are expressed as AA-NAT/cyc ratios. RESULTS: Chronic but not acute fluoxetine administration resulted in about a fivefold increase in hippocampal AA NAT mRNA. CONCLUSIONS: Up-regulation of extrapineal, e.g., hippocampal, AA-NAT expression may play a role in mediating the therapeutic action of antidepressant drugs. PMID- 9951565 TI - The cortical serotonin2 receptors studied with positron-emission tomography and [18F]-setoperone during depressive illness and antidepressant treatment with clomipramine. AB - BACKGROUND: Changes in serotonin (5-HT)2 receptor densities were reported in depression by postmortem studies and following treatment with tricyclic antidepressants in animal studies. Here, 5-HT2 receptors were studied in vivo in depressed patients. METHODS: Cortical 5-HT2 receptors were investigated prospectively using positron-emission tomography and [18F]-setoperone in 7 depressed patients, before and after at least 3 weeks of clomipramine (CMI), 150 mg daily. They were compared to 7 age-matched controls. RESULTS: There was no significant difference between the untreated patients and the controls, except in the frontal region, where the [18F]-setoperone specific binding was slightly lower in patients. After CMI treatment, depression scores significantly improved and [18F]-setoperone specific binding decreased in cortical regions, suggesting receptor occupancy and/or receptor regulation, by CMI; however, no clinical score correlated with the 5-HT2 receptor measurements either in the untreated or in the treated conditions. CONCLUSIONS: These data substantiate the view that tricyclic antidepressants such as clomipramine significantly interact with cortical 5-HT2 serotoninergic receptors in actual therapeutic situations. PMID- 9951566 TI - The relationship between poststroke depression and lesion location in long-term follow-up. AB - BACKGROUND: We have previously reported that during the acute poststroke period, poststroke major depression was significantly associated with left anterior lesions. Furthermore, we found that proximity of the lesion to the left frontal pole was correlated with severity of depression. Several investigators, however, have failed to replicate these findings when patients were studied beyond the acute stroke period. METHODS: We longitudinally examined the relationship between lesion size, lesion location, impairment variables, and the presence and severity of depression in 60 single lesion patients examined in-hospital and at short-term (3-6 months) and long-term (1-2 years) follow-up. RESULTS: Only in-hospital depression was significantly associated with left anterior hemisphere lesion location. At short-term follow-up, proximity of the lesion to the frontal pole, and lesion volume correlated with depression in both right and left hemisphere. At 1-2 years poststroke, depression was significantly associated with right hemisphere lesion volume and proximity of the lesion to the occipital pole. CONCLUSIONS: The anatomical correlates of poststroke depression change over time and may explain interstudy differences in the association of lesion location with poststroke depression. PMID- 9951567 TI - The differentiation of DSM-III-R psychotic depression in later life from nonpsychotic depression: comparisons of brain changes measured by multispectral analysis of magnetic resonance brain images, neuropsychological findings, and clinical features. AB - BACKGROUND: Psychotic depression has been proposed as a distinct subtype of major depression. There is considerable evidence for this in younger patients, although the neuroimaging has been rudimentary. Volumetric imaging studies are required of consecutive cohorts of patients with depression. METHODS: Ninety-nine consecutive elderly patients were diagnosed with DSM-III-R major depression. Eighteen were psychotic, and 81 were not. Sixty-six patients were given a neuropsychological test battery, and 44 had a magnetic resonance imaging brain scan. A model integrating clinical, psychological, and neuroimaging findings for the explanation of delusion formation during depression is proposed. RESULTS: Psychotic depression was characterized by worse physical health, more family history of depression, a poorer response to antidepressant drugs, and more severe lowering of mood; however, the strongest predictors of the presence of delusions were diencephalic atrophy, reticular activating system lesions, brain stem atrophy, and left-sided frontotemporal atrophy. The psychotic patients had poorer performance on tests of frontal lobe function and mental processing speed. CONCLUSIONS: In the elderly, psychotic depression is etiologically, clinically, and neuroradiologically distinct, and has different treatment requirements, from nonpsychotic major depression. PMID- 9951568 TI - Pretreatment REM sleep and subjective sleep quality distinguish depressed psychotherapy remitters and nonremitters. AB - BACKGROUND: We compared pretreatment subjective and electroencephalographic sleep measures among depressed patients who remitted with psychotherapy alone and those who did not remit. METHODS: Patients were 111 midlife women with recurrent major depressive disorder. Baseline psychiatric ratings and sleep studies were conducted prior to treatment with weekly interpersonal psychotherapy. Remission was defined as a score of < or = 7 for 3 consecutive weeks on the Hamilton Depression Rating Scale. Clinical and sleep measures were compared between remitters (n = 62) and nonremitters (n = 49) using t tests and random regression. Linear discriminant function analyses were used to categorize remitters and nonremitters on the basis of sleep measures. RESULTS: Treatment nonremitters had significantly worse subjective sleep quality and significantly elevated phasic REM sleep as measured by multivariate and univariate analyses. The linear accumulation of REM activity during sleep occurred at a significantly higher rate in nonremitters than in remitters. Linear discriminant function analyses based on subjective sleep quality and REM activity correctly identified 68.3% of nonremitters and 68.5% of remitters. CONCLUSIONS: These findings highlight the role of subjective and REM sleep measures as correlates of short-term psychotherapy treatment response in major depressive disorder. Disturbed sleep may be a physiological indicator of increased limbic and brain stem arousal. PMID- 9951569 TI - Vitamin B12 and folate levels and lithium administration in patients with affective disorders. AB - BACKGROUND: It is unclear whether there is a relationship between lithium administration and vitamin B12 metabolism. METHODS: We compared serum B12, serum folate, and red blood cell folate concentrations in patients receiving and not receiving lithium at two Mood Disorders Clinics. As the two centers differed in vitamin assay methods, data were first analyzed separately and then combined. To rule out an in vitro effect of lithium on the assays, we also added varying amounts of lithium to lithium-free blood samples and measured vitamin concentrations. RESULTS: Mean serum B12 concentrations were approximately 20% lower in the lithium than in the nonlithium group at each center. This difference was statistically significant for each center and on combination (two-tailed p = .017, .021, and .0009). The parametric effect size for each center and the combined weighted mean effect size were moderate in magnitude (.605, .523, and .565). There was a nonsignificant trend toward an increased prevalence of assay defined B12 deficiency in the lithium group at one center only, with no cases in either group at the other center and a nonsignificant combined relative risk. CONCLUSIONS: Our data may represent a lithium-associated decrease in serum B12 concentration. The clinical significance of these findings is not yet clear. PMID- 9951571 TI - Treatment of refractory chronic depression and dysthymia with high-dose thyroxine. AB - BACKGROUND: An 8-week open trial was conducted to investigate whether patients with treatment-resistant, chronic depression and/or dysthymia could profit from high-dose thyroxine (T4) augmentation. METHODS: Nine patients whose current depressive episode had lasted for a mean of 15.5 +/- 8.6 months (range: 2-30 months) received T4 in addition to their current medication. RESULTS: Two patients dropped out of the study owing to side effects. The remaining 7 patients received a final mean dose of T4 of 235 +/- 58 micrograms/day (range: 150-300 micrograms/day). Their scores on the Hamilton Depression Rating Scale had fallen from a mean of 21.1 +/- 4.1 before inclusion in the study to a mean of 8.0 +/- 2.8 at the end of the 8th week. Five patients were full responders, 1 a partial responder, and 1 a nonresponder. CONCLUSIONS: Augmentation with high-dose T4 proved to have an antidepressant effect in more than 50% of the previously treatment-resistant patients with chronic depression and/or dysthymia. PMID- 9951570 TI - Hypothalamic-pituitary-adrenal axis effects on plasma homovanillic acid in man. AB - BACKGROUND: Effects of the hypothalamic-pituitary-adrenal (HPA) axis on central dopaminergic systems have been proposed to underlie the development of psychotic symptoms in depression. This study examined HPA axis hormone effects on plasma levels of homovanillic acid (HVA), the dopamine metabolite, in healthy volunteers, using a placebo-controlled, double-blind, random-assignment, crossover design. On the basis of preliminary studies, we hypothesized that HPA axis hormones would produce delayed effects on plasma HVA levels measured in the afternoon. METHODS: Ten healthy subjects underwent a standard protocol on four occasions and each time received ovine corticotropin-releasing hormone, synthetic adrenocorticotropic hormone (ACTH), cortisol, or placebo. Plasma HVA was measured at 9 AM and 4 PM on Day 1, immediately prior to administration of the test substance at 7 PM, then at 30-60-min intervals until 11 PM. Plasma HVA levels were subsequently obtained at 9 AM and 4 PM on Days 2 and 3. RESULTS: As predicted, there were significant differences between test substances in delayed effects on afternoon HVA levels measured on Days 2 and 3, with cortisol and ACTH producing greater increases in HVA than placebo. Acute effects of HPA axis hormones on HVA were not found, while differences between test substances in delayed effects on morning HVA levels approached significance. CONCLUSIONS: HPA axis hormones exert delayed effects on plasma HVA levels in healthy humans. PMID- 9951573 TI - The effects of serotonin3 receptor blockade on the psychobiological response to intravenous clomipramine in healthy human subjects. AB - BACKGROUND: The purpose of this study was to determine the role that serotonin (5 HT)3 receptors play in the prolactin and nausea responses to clomipramine challenge. METHODS: Twenty healthy subjects were randomly assigned to pretreatment with either the selective 5-HT3 receptor antagonist ondansetron, or placebo, prior to intravenous infusion with clomipramine. RESULTS: Ondansetron pretreatment had no effect on the prolactin response to clomipramine challenge. There was a trend toward decreased nausea with ondansetron pre-treatment. CONCLUSIONS: These findings are consistent with other data suggesting that 5-HT3 receptors do not play a major role in the prolactin response to 5-HT challenge in human subjects, but may mediate nausea associated with enhanced 5-HT neurotransmission. PMID- 9951572 TI - Acute stress increases thyroid hormone levels in rat brain. AB - BACKGROUND: In experimental animals, exposure to uncontrollable stress induces a number of behavioral and biochemical changes that resemble symptoms seen in human depression and other psychiatric conditions. The present study used a yoked design to examine the effects of uncontrollable footshock stress on brain thyroid hormones in male and female rats. METHODS: Animals in one group received 15 trials where footshock could be terminated by pressing a lever (escapable shock). Rats in a second group received the same amount of shock, but had no control over shock termination (inescapable shock). Control rats received no shock. RESULTS: No significant differences were found among the three groups, for either males or females, in whole brain levels of thyroxine (T4) 3 hours after the footshock session. In contrast, significant group differences in brain levels of triiodothyronine (T3) were found for both males and females. In males, brain T3 was elevated by 21% in the inescapable shock group when compared to controls (p < .012). In females, brain T3 increased by 19% in the escapable shock group when compared to controls (p < .026). Plasma levels of both T3 and T4 were at control levels for all groups. CONCLUSIONS: These results provide the first demonstration that brain T3 levels change rapidly in response to acute stress. The data further suggest that the effects of stress controllability on brain T3 levels may be different for males and females. PMID- 9951574 TI - Possible dihydroepiandrosterone-induced mania. AB - BACKGROUND: Dehydroepiandrosterone (DHEA) is among the most abundant steroids in the human body and appears to have diverse biochemical activities. This multifunctional hormone has long been a compound of interest to research psychiatrists. Its recent promotion and availability as an over-the-counter supplement to the general public has led to widespread use. Little is known about potential adverse effects of DHEA when consumed on an acute or chronic basis. We report a case of mania in an older man acutely admitted to our psychiatric facility with no previous personal or family history of bipolar disorder that appeared to be related to recent DHEA use. The patient had initiated DHEA use 6 months prior to admission and was taking 200-300 mg/day at the time of presentation. METHODS: He was treated with valproic acid 500 mg twice daily. RESULTS: The patient showed sufficient improvement to be discharged following a 7 day inpatient hospitalization. CONCLUSIONS: A wide range of medications have been associated with the induction of hypomania and mania, and we have provided a brief discussion of the potential for DHEA to trigger manic symptoms. PMID- 9951575 TI - Lupron-induced mania. AB - BACKGROUND: Gonadotropins and sex hormones are intimately related to the stability of affective states. Patients with affective disorders may demonstrate abnormal levels of sex hormones and gonadotropins. It is therefore possible that affective disorder patients may experience mood dysregulation by synthetic sex hormones and gonadotropins like lupron. METHODS: A case report of a young woman with a history of endometriosis and a past history of irritability and depression is described. Treatment of the endometriosis with lupron induced a manic episode. RESULTS: The lupron-induced mania was successfully treated with a mood stabilizing agent, lithium carbonate. CONCLUSIONS: Patients with a history of affective disorder may develop manic episodes when treated with Lupron. Mood stabilizing agents are helpful in ameliorating this unwanted effect. PMID- 9951576 TI - Assessment of cell death. PMID- 9951577 TI - First clinical evaluation of the CELL-DYN 3200 haematology analyser. AB - A prototype of the CELL-DYN 3200 haematology analyser was evaluated in a tertiary care hospital laboratory. Precision, effects of sample ageing, linearity, carry over, and comparability of cellular blood counts and five-part leucocyte differentiation were determined in accordance with the ICSH guidelines for the evaluation of blood cell analysers; the results were satisfactory for all parameters tested: haemoglobin concentration, RBC, MCV, WBC, platelet count, and counts of neutrophils, lymphocytes, monocytes, and eosinophils. Two-hundred and forty-seven routine blood samples were used for the comparability studies. The cellular blood count results from the CELL-DYN 3200 and the Bayer Diagnostic H-1 systems corresponded closely (correlation coefficient r > 0.96 for all parameters). For 201 samples without an instrument-generated suspect flag the same was true with regard to the differential parameters, although somewhat lower correlation was observed for monocyte counts (r = 0.88). Comparisons to 400-cell microscopic differentials gave similar results (r > 0.93 for neutrophil, lymphocyte and eosinophil counts). Our results suggest that the CELL-DYN 3200 analyser will serve the needs for automated blood cell counting and differential leucocyte counting in a tertiary care hospital laboratory. PMID- 9951578 TI - Red blood cell depletion of cord blood using hydroxyethylstarch double sedimentation: analysis of 40 cases. AB - Cord blood has been shown to successfully reconstitute haematopoiesis following allogeneic transplantation in a variety of disorders. A major drawback of cord blood has been the risk of transfusion reaction secondary to ABO incompatibility and reduction in the stem cell pool if cord blood is manipulated to remove red cells. We report our experience on red blood cell depletion of cord blood (CB) with hydroxyethylstarch (HES) double sedimentation. The nucleated and mononucleated cell recovery passed from 78.4% at 90 min to 92.9% at 180 min and from 85% at 90 min to 96% at 180 min, respectively. The overall recovery of CCD34+ cells and of haemopoietic progenitors (CFU-GM) was 90.5% and 83.8%, respectively. The data indicate that HES double sedimentation is a simple and effective technique for cord blood manipulation, but further studies are necessary to evaluate the clonogenic progenitor recovery after thawing. PMID- 9951579 TI - Functional interaction of the gp80 and gp130 IL-6 receptors in human B cell malignancies. AB - IL-6, or cytokines of the IL-6 family using gp130 as transducer chain receptor, have been suggested to play a role in certain B lymphoid neoplasia. The presence of cell membrane gp80 and gp130 IL-6 receptors was studied in 98 patients with various leukaemia and non-Hodgkin's malignant lymphoma using flow cytofluorometry and immunohistology. Except neoplasia of immature B cells which expressed neither of the receptors, the majority of B cell tumours expressed one or both of them, mantle cell lymphoma being found to express the highest density of receptors. Using IL-6-dependent XG myeloma cell lines and mAb recognizing various gp80 and gp130 functional epitopes, it has been shown that IL-6 activation leads to a modified expression of some epitopes. In particular, the decrease or the disappearance of a gp130 epitope called A1 signed gp130 dimerization which is the first step of the gp130 activation pathway. Gp80 and gp130 epitope analysis was achieved in 17 of the patients. In four, an epitope phenotype compatible with a cytokine-induced activation was found. The cells of five B-CLL patients which expressed both gp80 and gp130 receptors were incubated with IL-6 to induce activation. In three of the cases they were found to rearrange their receptors in activated forms but not in the two others, showing that cells able to be activated or not can be found. These results confirm that gp130 signalling might play an important role in the pathogenesis of certain B cell neoplasia. PMID- 9951580 TI - The effects of cardiotoxic chemotherapy on blood pressure in patients with lymphoma. AB - Treatment for lymphoma often involves regimens containing doxorubicin and/or cyclophosphamide. Both are cardiotoxic and we have previously shown that the ascending and descending aorta can also be affected. In view of this we have measured the ambulatory blood pressures of patients newly diagnosed with lymphoma undergoing chemotherapy with and without cardiotoxic agents. Three separate 24 h recordings were taken: at the beginning, half-way through and on completion of treatment. There was no significant change in the blood pressure whether or not treatment included doxorubicin and/or cyclophosphamide containing regimens. Our findings suggest that the peripheral vasculature is not affected by standard first-line cardiotoxic chemotherapy in patients without known cardiovascular disease. PMID- 9951581 TI - Methylene tetrahydrofolate reductase C677T genotype and stroke. AB - High levels of homocysteine are associated with atherosclerosis. A thermolabile form of the enzyme methylene tetrahydrofolate reductase (MTHFR) has been proposed as a major cause of a genetic predisposition to hyperhomocysteinaemia and a point mutation at nucleotide 677 of the MTHFR gene causing a thermolabile MTHFR has been described. We looked for this mutation in 271 patients with CT proven cerebrovascular accidents and 173 control subjects. No significant difference in the frequency of the mutant genotype was found between patients with strokes and the control group. Separate analysis of those under 65 and subdividing stroke patients by anatomical location also revealed no significant difference. We conclude, therefore, that in this population the mutation evaluated is not a major contributor to the aetiology of cerebrovascular disease. PMID- 9951582 TI - Clinical experience with the use of clotting factor concentrates in oral anticoagulation reversal. AB - We report the clinical experience of a large Haemophilia Centre and Haemostasis Unit in reversing oral anticoagulation (OAC) using clotting factor concentrates. This is a retrospective study extending over 2 years (January 1996-December 1997). Reversal was performed using a combination of factor IX and factor VII concentrates administered by intravenous infusion. in a dose varying between 12 i.u./kg and 50 i.u./kg. We identified 20 episodes of OAC reversal in 18 patients, with a prevalence of 10 reversal episodes/1000 OAC patients/year. The median age was 77 years old (range 53-92 years). Indications for OAC reversal were divided into major bleeds (muscle haematoma [9], haematuria [3], subarachnoid haemorrhage [1], oesophageal bleeding [1], haemoptysis [1], haemarthrosis [1]); minor bleeds (extensive bruising [9], epistaxis [3], oral cavity bleeding [1]); and emergency invasive investigation (2). Pre-reversal, the international normalized ration (INR) was greater than 6.0 in 15/18 patients. Post-infusion. there was an immediate reduction in the INR towards normal (mean 1.3; range 1.1-2.3). There were no thrombotic complications or other adverse effects. The median use of factor 9 A concentrate was 2300 units/patient (range 570-4195), at a cost of 645 Pounds/patient and for factor VII concentrate 2200 units/patient (range 815 3630), at a cost of 664 Pounds/patient. Clotting factor concentrates provide a safe, rapid and effective means for OAC reversal and although expensive it is the treatment of choice in the over anticoagulated, bleeding patient. PMID- 9951583 TI - Laboratory control of oral anticoagulant therapy: preservation of prothrombin time specimens using a polypropylene collection system. AB - Previous studies have shown a marked time and temperature dependent shortening of the prothrombin time (PT) when blood is exposed to borosilicate (glass) or siliconized borosilicate tubes. Current recommendations are that samples for PT estimation should be tested within 2 h of collection. In this study using polypropylene collection tubes, blood obtained from 30 patients on oral anticoagulant therapy showed no significant change in International Normalized Ratio (INR) value after 24 h storage--either at 4 degrees C or room temperature. After 48 h. changes in INR values from refrigerated samples were still clinically insignificant. After 48 h storage at room temperature, however, a minority of samples showed an increase in INR value which may be of clinical importance. The range of INRs studied was 1.0-9.1. In a second evaluation, replicate specimens from 22 orally anticoagulated patients with INRs ranging from 1.0 to 9.6 showed no significant change after 24 h at either temperature--even when samples had been subjected to 30 min of gentle agitation prior to storage and analysis. Overall, the results indicate that when polypropylene collection tubes are used, prothrombin time specimens can be successfully preserved for up to 24 h at room temperature or up to 48 h when refrigerated. PMID- 9951584 TI - Paroxysmal cold haemoglobinuria of childhood: a review of the management and unusual presenting features of six cases. AB - We report six cases of children presenting with paroxysmal cold haemoglobinuria occurring in a 3-year period in the north-west of England. In all six cases the onset of the illness was dramatic and its duration brief. We note the prominent red cell agglutination was evident in the blood film, the absence of a prompt reticulocyte response and a negative classical direct Donath Landsteiner test in each of these cases. The Direct Coombs Test (DCT) was positive when anticomplement reagents were used but high titres of free autoantibody were not demonstrated in the serum. PMID- 9951585 TI - Chronic lymphocytic leukaemia in a patient with essential thrombocythaemia. AB - A patient who developed chronic lymphocytic leukaemia 6 years after an initial diagnosis of essential thrombocythaemia is described. This association, which was not treatment related, is extremely rare and only two other cases have been previously described in the literature. PMID- 9951586 TI - Clarence Livingood, MD. Interview by Victor H. Witten. PMID- 9951587 TI - Dermatitis in a musician. Part IV: Physiologic, emotional, and infectious problems in musicians. PMID- 9951588 TI - Bowel bypass syndrome without bowel bypass. AB - "Bowel bypass syndrome without bowel bypass" is an entity in which patients have the same clinical presentation as patients with bowel bypass syndrome, but with other gastrointestinal disorders. We present two cases of this disorder, one who responded to metronidazole and ciprofloxacin, and the other who responded to prednisone and metronidazole. PMID- 9951589 TI - A case of bullous frostbite following recreational snowmobiling. AB - Frostbite is the occurrence of localized tissue freezing and injury. It results following cold exposure of sufficient magnitude or duration to cause acute tissue damage. Although there are several conditions that predispose to frostbite, all are at risk if subject to sufficient cold exposure. We discuss a case of frostbite presenting with bullae localized to the neck resulting from extreme cold encountered while snowmobiling at night in Minnesota, an entity known by some local practitioners as "polaris vulgaris." PMID- 9951590 TI - Leukocytoclastic vasculitis as a cutaneous manifestation of systemic infection caused by Brucella melitensis. AB - A 22-year-old man with leukocytoclastic vasculitis as a cutaneous manifestation of brucellosis is presented. Skin lesions resolved 48 hours after starting treatment with tetracycline and rifampicin. Although skin manifestations are rarely associated with infection due to Brucella and do not seem to worsen the prognosis, they may cause the patient to seek medical attention as well as contribute to the diagnosis. PMID- 9951591 TI - Trauma-induced linear scleroderma. AB - Linear scleroderma (linear morphea) is a form of localized scleroderma characterized by sclerotic lesions distributed in a linear, band-like pattern. Despite its benign course, the disease can cause severe cosmetic, orthopedic, and psychologic problems. The cause is unknown. Many cases are preceded by a history of trauma. We describe a case in which linear scleroderma occurred following a laceration to the affected site. We review the treatment options and discuss the current theories regarding the pathogenesis of the disease. PMID- 9951592 TI - Hypersensitivity reactions to parenteral vitamin K. AB - Cutaneous hypersensitivity reactions to vitamin K are rare. They occur almost exclusively with fat-soluble vitamin K (K1). The lesion is most commonly a pruritic, indurated plaque at the site where the vitamin was injected. Most plaques resolve within 4 to 8 week without sequelae, but some progress to produce scar-like changes that may last for years. PMID- 9951593 TI - Amitriptyline-induced erythema annulare centrifugum. AB - A case of amitriptyline-induced superficial erythema annulare centrifugum (EAC) is reported. Its singular characteristics are prominent epidermal manifestations, with clinical and histologic vesiculation, associated with vacuolar degeneration at the dermoepidermal junction; numerous arciform lesions, accompanied by diffuse erythema on rechallenge; quick change, more rapid than that usually described for EAC; and a short course, in contrast with the usual chronic evolution of EAC. To our knowledge, this is the first reported case of EAC associated with amitriptyline intake. PMID- 9951594 TI - Solitary mastocytoma arising at a hepatitis B vaccination site. AB - On the first day of life, a healthy infant was given a recombinant hepatitis B vaccine. Over the following year, a 3 by 4.5 cm, well-defined, erythematous patch with an overlying white, reticulated, smaller plaque gradually appeared on her thigh at the vaccination site. Darier's sign was elicited at the site. Examination of a biopsy specimen showed an upper dermal mast cell infiltrate. This is the first reported case of a solitary mastocytoma appearing in a vaccination site. PMID- 9951595 TI - Tazarotene 0.1% gel in combination with mometasone furoate cream in plaque psoriasis: a photographic tracking study. AB - A photographic tracking study was performed to facilitate a visual evaluation of the effect of treating psoriatic lesions in a clinical setting with tazarotene 0.05% gel, tazarotene 0.1% gel, tazarotene 0.1% gel plus mometasone furoate as needed for irritation, or tazarotene 0.1% gel plus mometasone furoate. Tazarotene was administered once daily in the evening, and mometasone furoate was administered once daily in the morning, for 12 weeks or until clearance if this occurred first. A total of twenty patients were enrolled in this open-label study. Rates of treatment success (50% or greater improvement in psoriasis) were higher with tazarotene 0.1% monotherapy compared with tazarotene 0.05% monotherapy, and were higher still when tazarotene was used in combination with mometasone furoate. Concurrent use of this steroid also enhanced speed of efficacy, patient satisfaction, and tolerability. Furthermore, long periods of remission were achieved in patients treated with combination tazarotene plus corticosteroid therapy. These findings suggest that tazarotene plus a mid-potency topical corticosteroid is a valuable first-line treatment option for stable plaque psoriasis. PMID- 9951596 TI - Differential cytologic features of fibroepithelial lesions of the breast. AB - The surgical treatment of phyllodes tumors differs from that for fibroadenomas, with the former necessitating complete excision with no remaining neoplastic tissue to produce local recurrence. To determine whether we could predict the type of breast lesion on cytology we reviewed the cytological features of 39 fibroepithelial lesions, including ordinary fibroadenomas, fibroadenoma variants (intermediate group), benign phyllodes tumors, and malignant phyllodes tumors, which had a biopsy diagnosis and adequate cytology. We found no differences in the glandular elements, the myoepithelial and single stromal cells, and the type of stromal fragments seen in the three benign groups. The stromal nuclei, the number of leaf-shaped fragments, and the numbers of spindle-cell groups present showed a spectrum of changes varying from those of fibroadenomas at one end to those of benign phyllodes tumors at the other. Malignant phyllodes tumors had characteristic features which were quite different from those of the benign lesions. PMID- 9951597 TI - Cytologic diagnosis of malignant mesothelioma, with particular emphasis on the epithelial noncohesive cell type. AB - The effusion cytologies from 21 cases of malignant mesothelioma (MM) (15 pleural, 6 peritoneal) diagnosed at the Indiana University Medical Center during 1990-1997 were reviewed. Using the classification of Tao (Acta Cytol 1979;23:209-213), 13 cases of MM were of the epithelial cohesive cell type and 8 were of the epithelial noncohesive cell type. While the epithelial cohesive cell type has been discussed in the literature, the epithelial noncohesive cell type has not. The cytomorphologic features for both types are presented with particular emphasis on the noncohesive cell type. The differential diagnosis and use of ancillary confirmatory laboratory tests are briefly discussed. Because of its resemblance to florid reactive mesothelial hyperplasia and the general lack of awareness of the existence of the single-cell pattern of mesothelioma, this diagnosis can often be missed. PMID- 9951598 TI - Utility of cytokeratin 7 and 20 subset analysis as an aid in the identification of primary site of origin of malignancy in cytologic specimens. AB - This study was undertaken to assess the utility of combined cytokeratin (CK) 7/20 immunoprofile determination in malignant cytologic cell blocks as an aid to the identification of tumor primary site of origin. Fifty-one cases in which CK 7/20 immunocytochemistry was performed as part of the initial workup were retrieved. Their contribution to the final cytologic diagnosis of tumor primary site of origin was analyzed. CK reactivity patterns were 7+/20- (n = 34), 7-/20+ (n = 9), 7-/20- (n = 7), and 7+/20+ (n = 1). The CK 7+/CK 20- immunophenotype was the most common one obtained, and due to its wide expression in a number of common carcinomas, the least informative. The second most common immunophenotype was CK 7-/20+, which is associated with colorectal origin, and as such was very useful when obtained. The CK immunoprofile was more useful in the setting of a prior carcinoma, being a major diagnostic determinant in 13 cases (55%) from group 1 (those with a prior history of malignancy), compared to 8 cases (29%) from group 2 (those with no prior history of malignancy). In the setting of prior carcinoma, the CK immunoprofile is most useful when carcinomas under consideration have different expected immunoprofiles (e.g., CK 7+/CK20- carcinomas, including lung, breast, ovary, endometrium, and others, vs. CK 7-/CK 20+ carcinomas, primarily colorectal). When similar immunoprofiles are obtained, their usefulness is greater if they are immunoprofiles other than the most common 7+/20- pattern. Similarly, in newly diagnosed carcinomas, the CK immunoprofile either helps to narrow the differential diagnosis or points to a specific diagnosis. PMID- 9951599 TI - Cytomorphologic features of fine-needle aspiration of liposarcoma. AB - The cytomorphologic features of fine-needle aspirates (FNA) of liposarcomas have not been fully characterized. In the current study, we attempted to identify cytological attributes of liposarcoma in FNA. Twelve FNAs of histologically proven liposarcomas were used for this study. They included 10 myxoid and two well-differentiated liposarcomas. Four cytological criteria were chosen for evaluation. These included a complex capillary network, increased cellularity, the presence of a metachromatic stroma for myxoid liposarcoma, and finally the identification of lipoblasts. Eighteen FNAs of lipomas and 17 FNAs of nonlipomatous soft-tissue sarcomas were used as controls for evaluation of the same features. The diagnosis of liposarcoma had been rendered on FNA in 7 cases (58%). The diagnosis was suggested in 3 cases (25%), and a suggestion of sarcoma was rendered in 2 cases. Complex capillary networks were identified in 9 of 12 cases (75%); this was seen in 8 of the 10 myxoid liposarcomas and 1 of the 2 well differentiated neoplasms. Increased cellularity was seen in 7 of 12 cases (58%), metachromatic stroma was seen in 3 of 12 cases (25%), and lipoblasts were identified in 4 of 12 cases (33%). None of the lipomas or sarcomas exhibited a complex capillary network. When capillaries were identified in lipomas, they were straight, with minimal branching. The lipomas did not show evidence of increased cellularity in any cases. Metachromatic stroma was more frequently seen in the nonlipomatous sarcomas than in the liposarcomas. No lipoblasts were identified in any of the control FNAs. PMID- 9951600 TI - Use of the Thin Prep Pap Test in clinical practice. AB - The Thin Prep Pap Test (Cytyc Corp., Boxborough, MA) received approval by the Food and Drug Administration in May 1996 as an alternative to the traditional conventional smear. The present direct-to-vial study assessed the utility of thin layer technology for cervicovaginal screening in clinical practice. From May 1997 February 1998 (10 mo), 15,006 cervical smears were processed and evaluated; of these, 5,423 (36.1%) were conventional smears (CS) and 9,583 (63.9%) were Thin Prep slides (TP). Both methods were analyzed to compare specimen adequacy and detection rates of cervical lesions. The TP method reduced the "satisfactory but limited by" rate by 97% and the unsatisfactory rate by 63%. For low-grade squamous intraepithelial lesions (LSILs), TP slides yielded 3.6% (348/9,583) as compared to 0.98% (53/5,423) for CS, an increase of 267%. The TP method detected a threefold increase in the number of high-grade squamous intraepithelial lesions (HSILs) of 1.0% (100/9,583), as compared to 0.3% (17/5,425) for the CS group. The atypical squamous cells of undetermined significance/squamous intraepithelial lesion (ASCUS SIL) ratio was reduced by 54% in the TP group. In routine usage in our laboratory, the Thin Prep Pap Test yielded a significant increase in the detection of LSILs and HSILs as compared to conventional smears. Specimen adequacy was significantly improved. PMID- 9951601 TI - Fine-needle aspiration cytologic diagnosis of lymphocutaneous sporotrichosis: a case report. AB - A case of lymphocutaneous sporotrichosis initially diagnosed by fine-needle aspiration (FNA) cytology and confirmed by tissue biopsy and culture study is presented. Asteroid bodies and yeast cells with budding, highly suggestive of the disease, were seen in the cytologic and histologic preparations. The pathology of this unusual fungal disease and the role of cytology in the diagnosis are discussed. This is the first case of lymphocutaneous sporotrichosis reported in the cytologic literature as diagnosed by FNA cytology. PMID- 9951602 TI - Diagnosis of dermoid cyst of the floor of the mouth by fine-needle aspiration cytology: a case report. AB - A case of a dermoid cyst in the floor of the mouth in a 17-yr-old male is described. The diagnosis was made by fine-needle aspiration cytology and supported by histologic examination of the subsequently excised tissue. Dermoid cysts are benign lesions that can occur in the floor of the mouth. This case is presented to increase awareness of this entity and its occurrence in this location, and to demonstrate the feasibility of diagnosis by fine-needle aspiration. The cytologic and histologic features of dermoid cysts are described and discussed. PMID- 9951603 TI - Fine-needle aspiration cytology of adenoid cystic carcinoma of the breast. AB - Adenoid cystic carcinoma (ACC) of the breast is a rare variant of breast malignancy and has a better prognosis than its counterpart in the salivary glands. In this communication, our experience with seven cases of ACC of the breast is presented in which the diagnosis was established on fine-needle aspiration cytology (FNAC). The cytologic samples in all cases were cellular and featured three-dimensional clusters of uniform ductal epithelial cells with cystic spaces, bland nuclei, fine chromatin, and scanty cytoplasm arranged around spheres or cores of homogenous material. The cytodiagnosis of ACC in all cases correlated with subsequent examination of cell blocks of the aspirate and tissue. The cytodiagnostic criteria for ACC of the breast which are useful in a correct FNAC diagnosis are discussed. PMID- 9951604 TI - Diagnosis of posttransplant granulocytic sarcoma by fine-needle aspiration cytology and flow cytometry. AB - We describe a patient who developed granulocytic sarcomas of the mesentery and breast approximately 4 yrs following an allogenic bone marrow transplantation for acute myeloblastic leukemia. The diagnosis was made by a combination of fine needle aspiration cytology and flow cytometry. The differential diagnoses of localized masses in posttransplant patients and how the combination of fine needle aspiration cytology and flow cytometry may be used are discussed. PMID- 9951605 TI - Fine-needle aspiration biopsy cytology of hyalinizing trabecular adenomas of the thyroid. AB - Cytologic smears from fine-needle aspirates of three histologically and ultrastructurally confirmed hyalinizing trabecular adenomas of the thyroid (HTAT) were reviewed. In two cases a cytodiagnosis of HTAT was suggested, and in one patient a diagnosis of trabecular epithelial neoplasm was made. In all three cases, small clusters and sheets of epithelial cells with abundant, filamentous, vacuolated, and ill-defined cytoplasm were present. The nuclei were slightly pleomorphic and showed nuclear overlapping, nuclear grooves, and intranuclear cytoplasmic inclusions. Small and irregular fragments of acellular hyalinized material (AHM) were noted within the tumor cell clusters in the first two cases. In the third patient, large syncytial sheets and anastomotic cords of epithelial cells showing ill-defined, filamentous cytoplasm, slightly pleomorphic nuclei, nuclear overlapping, intranuclear cytoplasmic inclusions, and nuclear grooves were present. Fragments of AHM were not observed within clusters and syncytial sheets of tumor cells. PMID- 9951606 TI - Modification of CytoRich Red fixative system for use on bloody Pap and fine needle aspiration smears. AB - Recent work has shown CytoRich Red fixative system is effective in lysing red blood cells and reducing background in bloody fluid specimens. The scope of this study was to see whether CytoRich Red can lyse red blood cells in freshly prepared Pap and fine-needle aspiration smears. Paired smears from 20 bloody fine needle aspirations were prepared. One slide was initially placed in CytoRich Red for up to 30 sec, removed, and then fixed in 95% alcohol. The other slide was placed directly into 95% alcohol. Ten paired Pap smears, one fixed with a commercial fixative and another immersed in a solution of CytoRich Red, were evaluated. All slides were stained with the Papanicolaou stain and analyzed for the amount of red blood cells, background material, and nuclear and cytoplasmic staining. In 100% of all smears utilizing CytoRich Red, red blood cells were significantly reduced without hindering staining. Significant loss of cells from the slides sent in CytoRich Red solution was not observed. CytoRich Red fixative can be effective in reducing red blood cells and background on freshly made smears. In both gynecological and nongynecological cases, diagnostic cells were well preserved and not compromised by blood. PMID- 9951607 TI - Fine-needle aspiration biopsy using a newly-developed pencil-grip syringe holder. AB - Until now, commercially available syringe holders for fine-needle aspiration (FNA) were designed to be held in a pistol-grip manner. A newly developed, pencil grip syringe holder, the Tao Aspirator, was tested. The device is equipped with a release button for automatically drawing back the syringe plunger and a regulating knob for adjusting negative pressure for the aspiration. After direct smears were made for on-site examination, the remaining aspirated material was collected by rinsing the needle and syringe with CytoRich red fixative. Hettich cytocentrifuge preparations were then prepared. The quality of the first 150 FNA specimens procured by this device and prepared with liquid fixation was evaluated in terms of adequacy of specimen, amount of obscuring blood, preservation of cells, and ease of screening and interpretation. These 150 specimens included 32 from thyroids; 34 from breasts; 40 from lymph nodes; 24 from subcutaneous nodules; and 20 from salivary glands. There were no unsatisfactory specimens. In Hettich preparations, red blood cells were lysed, making interpretation easier. All cellular elements and tissue fragments were adequately fixed, showing excellent cellular morphology. Specimens fixed in liquid fixative yielded uniform cell suspensions, resulting in cytocentrifuge preparations with evenly distributed cells, and so the screening was also easier. The aspiration techniques using pistol-grip and pencil-grip FNA syringe holders were also compared in terms of control in tissue sampling, ease of use, and safety. The pencil-grip syringe holder allowed greater tactile sensation of the texture of the lesion, and enabled the operator to use a single hand to place a needle into a target lesion with minimal error. This device placed the hand relatively close to the needle tip while the hand was in a position of natural function, imparting more control in tissue sampling. It was more easily manipulated, and could prevent dripping when cystic fluid was aspirated. Specimen collection using the Tao Aspirator and processing with liquid fixation in addition to direct smear preparations allowed the laboratory to consistently produce adequate cytologic preparations and cell blocks. PMID- 9951608 TI - Cytology of peritoneal keratin granulomas. PMID- 9951609 TI - Cytologic manifestations of advanced endometrial adenocarcinomas in cervical vaginal smears. PMID- 9951610 TI - Cytodiagnosis of synovial chondromatosis of knee joint from an aspirate. PMID- 9951611 TI - Proceedings of the 4th International Symposium on the Neurobiology and Neuroendocrinology of Aging. Bregenz, Austria, July 26-31, 1998. PMID- 9951613 TI - Man from the Hauslabjoch. AB - On September 19, 1991, at an altitude of 3,200 m (10,498 feet), the remains of a well-preserved, freeze-dried mummified body of a 3,000 BC, Late Stone Age man, was found on the Austrian-Italian border. Studies conducted at the University of Innsbruck have revealed that these are the remains of a 45-46-year-old male, 45 kg (99 lbs) (living weight) and 160 cm (5 feet, 2 inches) tall. Morphometric, pathophysiologic, paleobotanical, photogrammetric, anthropological, computer tomographic, and other studies have been conducted to determine the living conditions and possible causes of death of this Late Stone Age man. PMID- 9951612 TI - How and why we age. AB - After performing the miracles that takes us from conception to birth, and then to sexual maturation and adulthood, natural selection was unable to favor the development of a more elementary mechanism that would simply maintain those earlier miracles forever. The manifestations of this failure are called aging. Because few feral animals age, evolution could not have favored a genetic program for age changes. Natural selection favors animals that are most likely to become reproductively successful by developing better survival strategies and greater reserve capacity in vital systems to better escape predation, disease, accidents, and environmental extremes. Natural selection diminishes after reproductive success because the species will not benefit from members favored for greater longevity. The level of physiological reserve remaining after reproductive maturity determines longevity and evolves incidental to the selection process that acts on earlier developmental events. Physiological reserve does not renew at the same rate that it incurs losses because molecular disorder increases at a rate greater than the capacity for repair. These are age changes, and they increase vulnerability to predation, accidents, or disease. Failure to distinguish aging from disease has not only blurred our efforts to understand the fundamental biology of aging, but it has profound political and economic consequences that compromise the field of biogerontology. Changes attributable to disease, or pathological change, can be distinguished from age changes for at least four important reasons. Unlike any known disease, (1) age changes occur in every human given sufficient time, (2) age changes cross virtually all species barriers, (3) no disease afflicts all members of a species only after the age of reproductive success, and (4) aging occurs in all feral animals subsequently protected by humans, even when that species probably has not experienced aging for thousands or millions of years. The resolution of age-associated diseases will not advance our knowledge of aging, just as the resolution of the diseases of childhood did not advance our knowledge of childhood development. We have failed to convey that greater support must be given to a question that is rarely posed. It is a question that is applicable to all age-associated diseases, and its resolution will also advance our fundamental knowledge of aging: "Why are old cells more vulnerable to pathology and disease than are young cells?" During the first half of this century it was believed that because cultured normal cells were immortal, aging must be caused by extra-cellular events. Thirty-five years ago we overthrough this dogma when we found that normal cells do have a limited capacity to divide, and that age changes can occur intracellularly. We also observed that only abnormal or cancer cells are immortal. Normal cells are mortal because telomeres shorten at each division. Immortal cancer cells express the enzyme telomerase that prevents shortening. Recently, it was discovered that when the catalytic subunit of the telomerase gene is inserted into normal cells they become immortal. PMID- 9951614 TI - Brain imaging and age-related changes in cognition. AB - Although there is currently some debate as to the degree of structural changes in the brain that occur with age, there is little doubt that such changes occur. There also are physiological changes in many areas that could have implications for cognitive function in the elderly. One way to study the impact of these age related changes in the brain on cognition is to use neuroimaging techniques to examine brain activity during the performance of various tasks, and determine how this activity differs between young and older individuals. This approach has been used to study functions such as memory, perception, and attention, and it has generally been found that older individuals utilize different areas of the brain than do young subjects when carrying out the same cognitive task. This has led some researchers to suggest that older persons utilize different functional brain networks, perhaps to compensate for reductions of efficiency in some brain areas. The areas of the brain most often found to be more active during cognitive tasks in the elderly are the frontal lobes. Studies that have directly examined the functional networks utilized during cognition have found that older people do indeed have different functional interactions involving the frontal lobes, and therefore, utilize different functional networks. In some cases this differential activity has been accompanied by cognitive performance in the older participants that is equivalent to that seen in the young, suggesting that greater reliance on this brain region is related in some way to the maintained ability of the older individuals to perform the task. However, data collected to date on this issue are still limited, so although the evidence is intriguing, the definitive interpretation of these findings must await further experiments. PMID- 9951615 TI - Does growth hormone prevent or accelerate aging? AB - It is very well documented that plasma growth hormone (GH) levels decline with age in the human and in experimental animals, and there is considerable evidence that age-related changes in body composition may be caused by reduced function of the GH-IGF-I system. However, excessive GH levels are associated with reduced life expectancy in acromegalic patients and with symptoms of accelerated aging in GH transgenic mice. Hereditary dwarf mice deficient in GH, prolactin, and TSH live much longer than their normal siblings. Possible mechanisms of delayed aging in dwarf mice include lower core body temperature and reduced oxidative processes. It is suggested that the controversies concerning the apparent potential of GH to both prevent and accelerate aging may be reconciled by interpreting the results in light of the negative relationship between body size and life span within a species. PMID- 9951616 TI - Effects of glucocorticoids on oxidative stress-induced hippocampal cell death: implications for the pathogenesis of Alzheimer's disease. AB - Hippocampal neurons are among the first neuronal cells to degenerate in the brain of patients affected by Alzheimer's disease (AD). These neurons have endogenous glucocorticoid receptors (GRs) and are vulnerable to oxidative stress that has been implicated in the pathogenesis of AD. The activities of various steroids can have an impact on neuronal function and the sensitivity of neurons to different toxic insults. Here it is shown that glucocorticoids can enhance the oxidative cell death induced by the AD-associated amyloid beta protein and glutamate in mouse clonal hippocampal HT22 cells and in primary embryonal neurons from rat. Glucocorticoids may permanently suppress the activity of the transcription factor NF kappa B and may block endogenous NF kappa B-driven cell defense programs. Therefore, age-related alterations of glucocorticoid homeostasis appear to enhance GR activation and may render hippocampal neurons more vulnerable to oxidative insults. PMID- 9951617 TI - Stress and neurosteroids in adult and aged rats. AB - The progesterone derivative 3 alpha-hydroxy-5 alpha-pregnan-20 one (allopregnanolone/AP) and the deoxycorticosterone derivative 3 alpha-21-dihydroxy 5 alpha- pregnan-20 one (allotetra-hydrodeoxycorticosterone/THDOC) are endogenous neuroactive steroids endowed with neuromodulatory actions in the central nervous system. Their best-characterized membrane-receptor-dependent action consists in the amplification of GABA-gated chloride currents mediated by specific interactions with the GABAA receptor complex, which appears responsible for the pharmacological effects (anxiolytic, anticonvulsant, hypnotic/anaesthetic) of exogenously administered AP and THDOC. Several acute stress paradigms and different negative allosteric modulators (isoniazid and FG 7142) of GABAA receptors time dependently increase brain and plasma concentrations of AP and THDOC only in intact or sham-operated but not in adrenalectomized-orchiectomized rats. These results suggest that acute stress and inhibitors of GABAA receptors increase the brain and plasma neurosteroid concentrations via a reduction of the inhibitory action exerted by GABA on the hypothalamic-pituitary-adrenal axis. The comparison between the time course of the changes in GABAA receptor function and of their behavioral correlates (proconflict behavior) and that of the changes of endogenous neuroactive steroids are consistent with the view that AP and THDOC may play a role in restoring the GABAergic tone to prestress conditions, by limiting the duration and the extent of its stress-induced reduction. The acute stress-elicited increase of AP and THDOC is observed in adult as well as in aged rats, which show a reduced basal GABAergic transmission and a greater response to the effect of stress in terms of their brain cortical neuroactive steroid concentrations than adult rats. PMID- 9951618 TI - Neurosteroids, brain damage, and mental illness. AB - The steroidal environment of the brain has marked consequences for both its structure and function. Social or physical stress has deleterious results on hippocampal function. This can be replicated by raising corticoids, which are also highly responsive to stress. Corticosterone, the major glucocorticoid in the rat, induces neuronal death in primary hippocampal cultures. Elevated corticoids also induce mood changes, and these are well known to be associated with stress, particularly chronic stress such as social adversity accentuated by intercurrent aversive life events. DHEA, a second adrenal steroid, has a very different developmental history, increasing rapidly during childhood, reaching a peak in youth, and declining thereafter in both blood and CSF. DHEA, in contrast to corticoids, has brain protective actions. It reduces the neurotoxic actions of glutamate analogues (such as NMDA) as well as those of corticoids. Evidence from several sources suggests that DHEA can act as an antiglucocorticoid. DHEA levels are reduced in major depressive disorders in both adolescents and adults, and a raised cortisol/DHEA ratio (together with intercurrent life events) predicts delayed recovery. DHEA may have a role in the treatment of depression. Together, these findings suggest that altered steroidal environment, whether induced by stress or aging, can have appreciable results on the cellular structure of the brain as well as on its function, although links between the two sets of findings are still tentative. PMID- 9951619 TI - Estrogen, the ovary, and neutotransmitters: factors associated with aging. AB - Our studies in the C57BL/6J mouse have been designed to examine the interactions of aging and the ovary, and their mutual effects on neuroendocrine function. In the pituitary, ovarian status and not age determines responsiveness to gonadotropin hormone releasing hormone (GnRH), but estrogen (E2) is an important mediator in CNS changes, and removal of the ovary (OVX) is deleterious to the neuroendocrine hypothalamus. OVX for just six days in young animals results in synaptic loss between noradrenergic terminals and gonadotropin hormone releasing hormone (GnRH) neurons. Long-term OVX, hypothesized to protect against neuroendocrine aging, fails to guard against any studied age-related changes. Some age-related changes occur as early as midlife. Although neuron number remains constant at middle age, opiatergic neurons undergo significant functional changes by producing opiate antagonist peptides. This change appears to be caused by alterations in the prohormone convertases, which cleave propeptide to peptide. Altered peptides may trigger the loss of reproductive capacity. The midlife shift in opiate peptide production is a component of natural developmental processes that begin in the neonate and continue through old age. In the cholinergic system, E2 mediates numbers of cholinergic receptors, cholinergic neurons, and cholinergic-modulated memory systems in both young and old animals. Regardless of age, ovarian steroids, if present at physiologic levels, are beneficial to the neuroendocrine CNS, and long-term deprivation from ovarian-produced factors is deleterious in the systems we have examined. Our studies have shown that deprivation from ovarian steroid hormones in the female appears to be a major factor in the health of the CNS and in events associated with aging. PMID- 9951620 TI - Age-related changes in melatonin levels in humans and its potential consequences for sleep disorders. AB - Prior to three months of age there is little melatonin (MLT) secretion in humans. MLT production then commences, becomes circadian, and reaches its highest nocturnal blood levels between the ages of one to three years. During the remainder of childhood, nocturnal peak levels drop progressively by 80%. In adults, these levels show an additional drop of some 10%, mainly during senescence. The large drop in serum MLT during childhood is probably the result of the increase in size of the human body, despite a constant MLT production after infancy. The additional decline of MLT with higher age may be due to a yet unidentified physiological mechanism accompanying senescence. The biological significance of these MLT alterations remains unknown. Since the discovery of MLT, an immediate sedative action of this hormone has been known. A number of recent studies have demonstrated that MLT indeed exerts a sleep-promoting action by accelerating sleep initiation, improving sleep maintenance, and marginally altering sleep architecture. The potential of MLT in the treatment of insomnia is being explored, and the results are promising. Although in most of these studies pharmacological dosages of MLT have been used, preliminary data suggest that similar effects can also be achieved by physiological hormone concentrations. The latter observation raises the question of whether MLT might be involved in the physiological control of sleep. PMID- 9951621 TI - Genetics of longevity. AB - Recent studies on the genetics of aging in the yeast Saccharomyces cerevisiae, the roundworm Caenorhabditis elegans, and the fruit fly Drosophila melanogaster have converged revealing the central role of metabolic capacity and resistance to stress in determining life span. Signal transduction has emerged from these studies as an important molecular mechanism underlying longevity. In their broad features, the results obtained in these genetic models are applicable to the dietary restriction paradigm in mammals, suggesting a general significance. It will be of interest to determine whether many of the molecular details will also pertain. The examination of centenarian populations for the frequency of certain alleles of pertinent genes may provide insights into the relevance of the conclusions of studies in invertebrates to human aging. These population genetic studies can be augmented by mechanistic studies in transgenic mice. PMID- 9951622 TI - The experimental evolution of aging in fruitflies. AB - The evolutionary theory of aging suggests that the level of repair will evolve to an intermediate optimum that permits the accumulation of random damage to cells. This, in turn, causes a decline in essential functions during the life span of an organism. The central claim of the life history theory of aging is that intrinsic mortality rates evolve in response to changes in extrinsic mortality rates. To prove this central claim, it must be evaluated experimentally. Experimental evolution is an approach that has been yielding interesting results from both a variety of questions posed and organisms examined. In this article the organism chosen for study is the fruitfly (Drosophilia melanogaster) in which the evolutionary effects of high and low adult mortality rates are compared. It has been found that higher extrinsic mortality rates lead to the evolution of higher intrinsic mortality rates and a shorter life span. This is the first clear experimental demonstration of the central claim of the evolutionary theory of aging. PMID- 9951623 TI - Application of gene therapy to treat age-related loss of dopamine D2 receptor. AB - We have investigated the feasibility of using gene therapy to attenuate the age related decline in striatal dopamine D2 receptors (D2R) associated with reduced motor control. To this end, we have constructed an adenoviral vector containing the cDNA for the rat D2R. When injected into HeLa and HS24 cells in vitro, the vector induced an abundant message for D2R, as demonstrated by Northern analysis, and produced a membrane-bound protein capable of binding a D2R ligand, [3H]spiperone. When injected into rat striatum in vivo, the vector produced a marked increase in D2R near the site of injection, as evidenced by increased [3H]spiperone binding as well as by another more specific ligand, [125I]iodosulpride. The D2R produced in the striatum were functional, as evidenced by rotational behavior induced by a subcutaneous injection of the dopamine agonist, apomorphine. However, we did not observe any significant improvement in motor performance during preliminary experiments in which aged rats received bilateral striatal injections of the vector. In young rats, vector induced expression of D2R in striatum was increased markedly three to five days after infection, but then declined to baseline levels by day 21. Loss of expression in aged rats proceeded at a somewhat lower rate. Because of the loss of expression and lack of significant performance enhancement in aged rats following vector injection into the striatum, we are now pursuing other strategies. These include functional assessment of the current vector in D2R null mutant mice as well as construction of new vectors that may yield more long-term expression. PMID- 9951624 TI - Transcriptional activation by the Werner syndrome gene product in yeast. AB - Werner syndrome (WS) is characterized by the premature occurrence of many age related features. Before the cloning of the gene for WS (WRN), several reports suggested that transcriptional defects of genes may relate to the mechanisms of the occurrence of WS and natural aging. Because WRN, which encodes a helicase (WRN-H), has been cloned, we are attempting to clarify the mechanism of the transcriptional abnormalities found in WS cells, using WRN and WRN-H. In this article, we studied transcriptional activation of a promoter by WRN-H in a yeast assay system as a first step. The results showed that WRN-H functions as a transcriptional activator in the system. Furthermore, we performed additional transcriptional assays using various parts of WRN to define the critical region of WRN-H for transcriptional activation in yeast. The results revealed the critical region for the activation most likely mapped to the region of 315 to 403 aa. The region of 404 to 1309 aa may also effect activation in the presence of the critical region. The two regions contain an acidic domain, and the region of 404 to 1309 aa also contains a helicase domain. If this transcriptional activation by WRN-H occurs also in human cells in vivo, direct activation of the promoters by WRN-H could explain the results of somatic cell hybrid studies as well as the overexpressed genes detected in WS cells. However, our results should be interpreted with caution, because thus far, the transcriptional activation by WRN-H were only demonstrated using one promoter in a yeast system. PMID- 9951625 TI - The nitric oxide hypothesis of aging. AB - Nitric oxide (NO), generated by endothelial (e) NO synthase (NOS) and neuronal (n) NOS, plays a ubiquitous role in the body in controlling the function of almost every, if not every, organ system. Bacterial and viral products, such as bacterial lipopolysaccharide (LPS), induce inducible (i) NOS synthesis that produces massive amounts of NO toxic to the invading viruses and bacteria, but also host cells by inactivation of enzymes leading to cell death. The actions of all forms of NOS are mediated not only by the free radical oxidant properties of this soluble gas, but also by its activation of guanylate cyclase (GC), leading to the production of cyclic guanosine monophosphate (cGMP) that mediates many of its physiological actions. In addition, NO activates cyclooxygenase and lipoxygenase, leading to the production of physiologically relevant quantities of prostaglandin E2 (PGE2) and leukotrienes. In the case of iNOS, the massive release of NO, PGE2, and leukotrienes produces toxic effects. Systemic injection of LPS causes induction of interleukin (IL)-1 beta mRNA followed by IL-beta synthesis that induces iNOS mRNA with a latency of two and four hours, respectively, in the anterior pituitary and pineal glands, meninges, and choroid plexus, regions outside the blood-brain barrier, and shortly thereafter, in hypothalamic regions, such as the temperature-regulating centers, paraventricular nucleus containing releasing and inhibiting hormone neurons, and the arcuate nucleus, a region containing these neurons and axons bound for the median eminence. We are currently determining if LPS similarly activates cytokine and iNOS production in the cardiovascular system and the gonads. Our hypothesis is that recurrent infections over the life span play a significant role in producing aging changes in all systems outside the blood-brain barrier via release of toxic quantities of NO. NO may be a major factor in the development of coronary heart disease (CHD). Considerable evidence has accrued indicating a role for infections in the induction of CHD and, indeed, patients treated with a tetracycline derivative had 10 times less complications of CHD than their controls. Stress, inflammation, and infection have all been shown to cause induction of iNOS in rats, and it is likely that this triad of events is very important in progression of coronary arteriosclerosis leading to coronary occlusion. Aging of the anterior pituitary and pineal with resultant decreased secretion of pituitary hormones and the pineal hormone, melatonin, respectively, may be caused by NO. The induction of iNOS in the temperature-regulating centers by infections may cause the decreased febrile response in the aged by loss of thermosensitive neurons. iNOS induction in the paraventricular nucleus may cause the decreased nocturnal secretion of growth hormone (GH) and prolactin that occurs with age, and its induction in the arcuate nucleus may destroy luteinizing hormone-releasing hormone (LHRH) neurons, thereby leading to decreased release of gonadotropins. Recurrent infections may play a role in aging of other parts of the brain, because there are increased numbers of astrocytes expressing IL-1 beta throughout the brain in aged patients. IL-1 and products of NO activity accumulate around the plaques of Alzheimer's, and may play a role in the progression of the disease. Early onset Parkinsonism following flu encephalitis during World War I was possibly due to induction of iNOS in cells adjacent to substantia nigra dopaminergic neurons leading to death of these cells, which, coupled with ordinary aging fall out, led to Parkinsonism. The central nervous system (CNS) pathology in AIDS patients bears striking resemblance to aging changes, and may also be largely caused by the action of iNOS. Antioxidants, such as melatonin, vitamin C, and vitamin E, probably play an important acute and chronic role in reducing or eliminating the oxidant damage produced by NO. PMID- 9951626 TI - Effects of steroid hormones on gene expression of glial markers in the central and peripheral nervous system: variations induced by aging. AB - The present article summarizes our data regarding: (a) the effect of sex steroids on the expression of a specific astrocytic marker in glial cell cultures (GFAP); (b) the effects of aging on two markers of the peripheral myelin (glycoprotein Po and the myelin basic protein, MBP); (c) the possible modification of the damaging effects of aging on these two markers by the in vivo administration of progesterone and its derivatives; and, finally, (d) the effect of progesterone derivatives on the gene expression of Po in cultures of rat Schwann cells. The data obtained have indicated that progesterone and its 5 alpha-reduced metabolites may play an important role in the control of gene expression of GFAP and Po, respectively, in type 1 astrocytes and Schwann cells. It has also been found that the gene expression of Po and MBP is dramatically decreased in the myelin of the sciatic nerve of aged male rats and that the aged-linked decrease of the gene expression of Po is partially reversible with steroid treatment. PMID- 9951628 TI - The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system. AB - The neural cell adhesion molecule (NCAM) is a member of the immunoglobulin superfamily and is strongly expressed in the nervous system. NCAM is found in three major forms, of which two--NCAM-140 and NCAM-180--are transmembrane proteins, while the third--NCAM-120--is attached to the membrane via a glycosylphosphatidyl inositol anchor. In addition, soluble NCAM forms exist in brain, cerebrospinal fluid, and plasma. NCAM mediates cell adhesion through homophilic as well as through heterophilic interactions. Following NCAM binding, transmembrane signalling is believed to be activated, resulting in increased intracellular calcium. By mediating cell adhesion to other cells and to the extracellular matrix and by activating intracellular signaling pathways, NCAM influences cell migration, neurite extension, and fasciculation, and possibly formation of synapses in the brain. From studies on NCAM knock-out mice, NCAM have been shown to be crucial for the formation of the olfactory bulb and the mossy fiber system in the hippocampus. In addition, NCAM is important for neuronal plasticity in the adult brain associated with learning and regeneration. PMID- 9951627 TI - Diffusion constraints and neuron-glia interaction during aging. AB - Changes in brain extracellular space (ECS) volume, composition, and geometry are a consequence of neuronal activity, of glial K+, pH, and amino acid homeostasis, and of changes in glial cell morphology, proliferation, and function. They occur as a result of repetitive neuronal activity, seizures, anoxia, injury, inflammation, and many other pathological states in the CNS, and may significantly affect signal transmission in the CNS. Activity-related or CNS damage-related cellular swelling is compensated for by ECS volume shrinkage and, as a consequence, by a decrease in the apparent diffusion coefficients (ADCs) of neuroactive substances diffusing in the ECS. Changes in cellular morphology, such as occur during aging, could also result in changes of ECS volume and geometry. We provide evidence for limited diffusion in rat cortex, corpus callosum, and hippocampus in the aging brain that correlates with changes in glial volume and the extracellular matrix. In all structures, the mean ECS volume fraction alpha (alpha = ECS volume/total tissue volume) and nonspecific uptake k' are significantly lower in aged rats (26-32 months old) than in young adult brain. Compared to young adult brain, in the aged brain we found an increase in GFAP staining and hypertrophied astrocytes with thicker processes which, in the hippocampus, lost their radial organization. The tortuosity (lambda = square root of D/ADC) was lower in the cortex and CA3 region. Immunohistochemical staining for fibronectin and chondroitin sulfate proteoglycans revealed a substantial decrease that could account for a decrease in diffusion barriers. Diffusion parameters alpha, lambda, and k' in the aging brain after cardiac arrest changed substantially faster than in the young adult brain, although the final values were not significantly different. This suggests that the smaller extracellular space during aging results in a greater susceptibility of the aging brain to anoxia/ischemia, apparently due to a faster extracellular acidosis and accumulation of K+ and toxic substances, for example, glutamate. We conclude that during aging the movement of substances is more hindered in the narrower clefts. This is partly compensated for by a decrease in the diffusion barriers that may be formed by macromolecules of the extracellular matrix. Diffusion parameters can affect the efficacy of synaptic as well as extrasynaptic transmission by a greater accumulation of substances, because they diffuse away from a source more slowly, or induce damage to nerve cells if these substances reach toxic concentrations. Diffusion parameters are also of importance in the "crosstalk" between synapses, which has been hypothesized to be of importance during LTP and LTD. We can, therefore, assume that the observed changes in ECS diffusion parameters during aging can contribute to functional deficits and memory loss. PMID- 9951629 TI - Aging, Alzheimer's disease, and estrogen therapy. AB - Experimental studies in vivo and in vitro, as well-retrospective studies in post menopausal women suggest that taking estrogens for a number of years may reduce the risk to develop Alzheimer's Disease (AD). Because these conclusions are drawn mainly on the basis of retrospective studies, large, randomized, placebo controlled trials are necessary before recommending use of estrogens to women for the prevention of AD. PMID- 9951630 TI - The possible role of the immune system in Alzheimer's disease. AB - Currently, there is little doubt that the immune system plays a role in the neurodegenerative process in Alzheimer's disease (AD). Inflammatory proteins such as complement components, enzymes, eicosanoids, and cytokines are found in association with cerebral amyloid plaques and may exacerbate the fundamental pathology of AD, by stimulating Amyloid beta (A beta) production, supporting its aggregation and increasing its cytotoxicity. Activated microglia and astrocytes are the main source of these proteins, and A beta may trigger their release. Interestingly, there are also indications that the immune system may play a protective role against the development of AD. Microglial cells have been shown to degrade A beta, and recent evidence suggests that autoreactive A beta-specific T cells may be relevant to the elimination of the peptide. This mechanism seems, however, impaired in the majority of patients with AD. The immune system seems thus to represent a natural line of defense against the accumulation of dangerous amyloidogenic substances. Impairment of this specific immunological defense mechanism and the failure to eliminate a toxic metabolite can be the basis for a chronic nonspecific inflammatory process in the brain, as described above. AD is a good example how an immune response initially aiming at maintaining the integrity of the body may fail and consequently lead to tissue destruction and neuronal loss. PMID- 9951631 TI - Transgenic mice expressing Alzheimer amyloid precursor proteins. AB - Nearly a decade after the identification of the Alzheimer amyloid precursor protein (APP) gene several groups of investigators have created transgenic mice expressing APP that simulate some of the prominent behavioral and pathological features of Alzheimer's disease (Quon et al., 1991; Games et al., 1995; Hsiao et al., 1995, 1996; Moechars et al., 1996; Sturchler-Pierrat et al., 1997). These features, which are present to various degrees in different lines of mice, include age-related impairment in learning and memory, neuronal loss, gliosis, neuritic changes, amyloid deposition, and abnormal tau phosphorylation. No mouse model exhibiting every neuropathological feature of Alzheimer's disease exists. Whether an exact simulation of Alzheimer neuropathology is required to understand neural dysfunction in Alzheimer's disease is unclear. Various mouse models of Alzheimer's disease are summarized in this article. PMID- 9951632 TI - Natural anticoagulants, aging, and thromboembolism. AB - The normal aging process alters blood coagulation system in humans; this may be of great concern in the view of the known association of vascular disease with advancing age. The plasma concentration of several coagulation factors, namely fibrinogen, factor VII, factor VIII, factor IX, high molecular-weight kininogen, and prekallikrein, increase in healthy humans, paralleling the physiological aging process. Plasma parameters of clotting activation in vivo, such as prothrombin fragment 1 + 2, fibrinopeptide A, thrombin-antithrombin III complex, and D-dimer, are positively correlated with age. Nevertheless, among centenarians, biochemical signs of marked hypercoagulability are associated with a healthy state. Natural anticoagulants, including antithrombin III, heparin cofactor II, protein C, protein S, and tissue factor pathway inhibitor, can modulate the reactions of blood coagulation system. The occurrence of menopause is accompanied by a significant increase in antithrombin III plasma level; the mean antithrombin III levels in older women exceed levels in male contemporaries. In healthy elderly subjects heparin cofactor II plasma concentrations are lower than in young subjects, independently of gender. Protein C levels raise with age in both sexes, as well as free protein S levels. In women, statistically significant increases in the plasma concentration of the tissue factor pathway inhibitor have been observed, whereas no significant age-related change has been found in men. The fact that many subjects with congenital defects of natural anticoagulants do not undergo thromboembolic events in young age suggests that in healthy individuals a raise in natural anticoagulants can balance the age-related increase of procoagulant factors. PMID- 9951633 TI - Aging and the adrenal cortex. AB - Aging in humans is accompanied by an increase in adrenal glucocorticoid secretion and a decline in adrenal androgen synthesis and secretion. The intense interest in adrenal function in aging individuals in recent years is in large measure related to the potential impact of cortisol excess in the development of cognitive impairment and hippocampal neuronal loss, and to the desire to provide hormone replacement and healthy aging. Although the preliminary data is tantalizing, solid scientific evidence are not at hand. It is apparent that both issues are extremely complex. Dehydroepiandrosterone (DHEA) and its 3 beta sulfate are fascinating molecules, including their synthesis and actions in the brain. Recent studies have shown that DHEA-sulfate (DHEA-S), but not DHEA, activates peroxisome proliferator-activated receptor alpha (PPAR alpha) in the liver, an intracellular receptor belonging to the steroid receptor superfamily. Thus, DHEA-S may serve as a physiological modulator of liver fatty acid metabolism and peroxisomal enzyme expression, and thereby may contribute to the anticarcinogenic and chemoprotective properties of this intriguing class of endogenous steroids. The life-sustaining role of adrenal cortisol secretion and its regulation of metabolism via catabolic actions may be modulated by its partner DHEA and DHEA-S. During the anabolic growth period (childhood and early adulthood) the body is exposed to relatively high levels of DHEA/DHEA-S but to relatively or absolutely high levels of cortisol during infancy and the aging phase. The cortisol/DHEA-S ratio during the life span follows a U-shape curve, which may be telling us to explore these two critical adrenal steroids in tandem. PMID- 9951634 TI - Distribution of pigment epithelium autofluorescence in retinal disease state recorded in vivo and its change over time. AB - BACKGROUND: Recently a technique of imaging the retinal pigment epithelium (RPE) has been developed that takes advantages of its intrinsic fluorescence derived from lipofuscin. The purpose of this study was to document the distribution of fundus autofluorescence in patients with various retinal diseases and its change over time. METHODS: The intensity and spatial distribution of fundus autofluorescence was documented in 318 eyes from 159 patients with various retinal diseases using a confocal Laser Scanning Ophthalmoscope. Thirty patients with macular dystrophies and 30 with age-related macular disease underwent serial examinations over a period of 1-3 years in order to monitor the changes over time of fundus autofluorescence. RESULTS: Absent autofluorescence corresponded well spatially with outer retinal atrophy in eyes with retinitis pigmentosa and rod cone dystrophy. Abnormally high background autofluorescence was seen in the macular region in some patients with dominant and recessive retinitis pigmentosa and rod-cone dystrophies. In areas of macular edema fundus autofluorescence was abnormal. Fundus autofluorescence showed changes over time in most of the eyes with retinal diseases studied. CONCLUSION: Fundus autofluorescence allows documentation of areas of photoreceptor cell loss in eyes with retinitis pigmentosa and rod-cone dystrophies. If abnormal high background autofluorescence in the surviving areas occurs only in some patients with retinitis pigmentosa, the technique may serve to distinguish the regional from the diffuse type of disease. Over time, fundus autofluorescence may demonstrate change or may remain stable. PMID- 9951635 TI - Surgical extraction of subfoveal choroidal new vessels and submacular haemorrhage in age-related macular degeneration: results of a prospective study. AB - BACKGROUND: The surgical extraction of subfoveal choroidal new vessels (CNV) is one of several possibilities to treat subfoveal CNV or haemorrhages in age related macular degeneration (ARMD). METHODS: Prospective study, follow-up 3-6 months. Clinical and angiographic differentiation of three subgroups: (1) subfoveal well-defined CNV (24 eyes); (2) subfoveal ill-defined CNV with or without well-defined components (10 eyes); (3) submacular haemorrhages (20 eyes). RESULTS: The mean and median visual acuity and the proportion of eyes with > or = 20/200 vision increased slightly in group 1 and decreased slightly in group 2; the differences were not significant. Group 3 demonstrated mean improvement but was heterogeneous, depending on the site and type of underlying CNV. The proportion of eyes with 3 or more lines of improvement after 3 months was 35.3% (7/17), 10% (1/10) and 38.9% (7/18) respectively. The proportion of eyes with a loss of 3 or more lines after 3 months was 5.9% (1/17), 20% (2/10) and 5.6% (1/18) respectively. The recurrence rate was 29.2% (7/24), 8.3% (1/11) and 25% (5/20). Intraoperative complications were iatrogenic central tears in 7.3% (4/55), peripheral tears in 14.5% (8/55) and peripheral retinal detachment in 3.6% (2/55). A postoperative retinal detachment was observed in 2 of 55 eyes (3.6%). All these complications could be managed without ill effect. CONCLUSION: Subfoveal surgery might preserve remaining retinal function in eyes with well defined CNV. However, subgroups of the MPS subfoveal laser trials with comparable initial visual acuity demonstrated postoperative functional stabilisation and similar recurrence rates in well-defined CNV. Though selected cases of submacular haemorrhage did profit from surgery, TPA-assisted gas injection will probably be a better alternative. Unfortunately, surgery for ill-defined CNV, found in the vast majority of eyes with exudative ARMD, seems to worsen the natural course. Surgery has to be combined with restoration of Bruch's membrane before it can become a possible therapeutic option in ARMD. PMID- 9951636 TI - Information from false statements concerning visual acuity and visual field in cases of psychogenic visual impairment. AB - BACKGROUND: If visual acuity (VA) and/or visual field (VF) is claimed to be worse than in reality, it can be difficult to estimate the actual VA/VF. This paper describes a method of proving malingering and of estimating the actual VA by statistical evaluation of the subjective responses to discrete visual stimuli. METHODS: VA is measured by using a Landolt or Snellen optotype with four possible directions. There are n (> or = 16) questions at each acuity level. Each direction of the optotype occurs with the same frequency. The sequence is not predictable. In testing the VF, the stimulus is presented in an unpredictable sequence but with the same frequency at each of four distinct locations outside the claimed field at the horizontal and the vertical meridian. The field is divided into four quadrants defined by the 45 degrees-225 degrees and 135 degrees 315 degrees meridians. The candidate is requested to search for the light. The target quadrant of the first eye movement is recorded. At each VA level, the distribution function of the binomial formula allows estimation of the probability Pc of < or = kc and > or = kc correct answers to n questions by mere accident. Regarding the VF, the direction of the first saccade at each stimulus presentation can be processed accordingly. RESULTS: If n = 32 and kc = 0,1,2, the chance P that this pattern is merely accidental is about 0.0001, 0.001, 0.007. Values of P < or = 0.01 strongly suggest that the answers were voluntarily wrong. Preference for the opposite direction can also point to psychogenic influence: If ko = 15,16,17,18, P is about 0.006, 0.002, 0.0006, 0.0002. CONCLUSION: Systematically false statements can yield valuable information about the actual visual functions. PMID- 9951637 TI - Eye position changes induced by neck muscle vibration in strabismic subjects. AB - BACKGROUND: In normal subjects vibratory stimulation of neck muscle proprioceptors can induce eye position change and visual illusory movement. The direction of apparent movement is vertical when the back muscles of the neck are stimulated and horizontal when lateral-rotation muscles are stimulated. The effect of muscle proprioceptor stimulation in individuals with defects in binocular vision, such as strabismus, has not been studied previously and is the subject of the present report. METHODS: In 23 strabismic patients with different levels of binocular vision, 70-Hz mechanical vibration was applied to three groups of neck muscles under both dark and normal light conditions, and eye position changes were recorded for each eye using an infrared reflection technique. The dominant eye fixated on a target while the non-dominant eye was covered. RESULTS: When the back muscles were stimulated, eye position changed in a downward direction, as previously demonstrated in the normal subjects. However, in strabismic subjects with poor binocular vision, stimulation of the horizontal rotation neck muscles resulted in eye position changes generally to the same side regardless of the muscle group activated. This differed from normal subjects, where the direction of the eye position changes is related to the group of muscles stimulated. The direction and amplitude of the eye position changes were the same under dark and light conditions. CONCLUSION: Proprioceptive information from neck muscles plays an important role in regulation of gaze direction. The difference that exists between normal subjects and strabismic patients is most likely related to differences in binocular function. PMID- 9951638 TI - Clinical evaluation of SITA: a new family of perimetric testing strategies. AB - PURPOSE: To perform a clinical comparison of the Humphrey Full Threshold strategy with its intended replacement, SITA Standard, regarding testing time, reproducibility, and measured threshold sensitivity in normal subjects and glaucoma patients. METHODS: Thirty-eight healthy volunteers and 80 patients with primary open-angel glaucoma underwent central 30-2 testing with both Full Threshold and SITA strategies using a Humphrey HFA 2 Model 740 perimeter. The testing time, reproducibility, and measured threshold sensitivity of the two strategies were compared. RESULTS: The testing time for measurements with SITA was 56% lower in normal subjects and 45% lower in glaucoma patients than with Full Threshold. Cases having higher mean sensitivity or cases requiring longer testing time for Full Threshold had a greater percentage reduction in testing time for SITA. The test-retest variability studied in normal subjects was lower, but not significantly so, with SITA (2.9%) than with Full Threshold (3.4%). The mean sensitivities of SITA were higher (1 dB) than those of Full Threshold not only in normal subjects but also in glaucoma patients. This higher sensitivity in SITA was found irrespective of the order of the two tests both in normal subjects and glaucoma patients. Analysis by each testing point revealed that the difference was not dependent on the test point position or the sensitivity at the point. CONCLUSION: SITA has greater patient acceptability than the Full Threshold strategy. However, the difference in sensitivity can be considerable in a serial comparison of one patient's fields tested by Full Threshold and SITA. PMID- 9951639 TI - Ten years' surveillance of viral conjunctivitis in Sapporo, Japan. AB - BACKGROUND: We set out to establish the epidemiology of viral conjunctivitis over a 10-year period in Sapporo, northern Japan. METHODS: A total of 965 patients with clinically suspected viral conjunctivitis during the 10-year period from 1985 to 1994 in Sapporo were evaluated. RESULTS: Among the 965 patients, cumulative frequency of adenovirus (Ad) was 721 (75%). The dominant serotype of Ad changed with time; each serotype peaked at 3- to 5-year intervals. Adenoviral conjunctivitis occurred most often in July and August each year. Ad3 and Ad4 were predominantly identified in patients 30-39 years old. No enterovirus 70 has been detected. Herpes simplex virus (HSV) and Chlamydia trachomatis had no significant peak. HSV was isolated throughout the year, and C. trachomatis had two peaks of detection: in March and from July to September. HSV and C. trachomatis were predominantly detected in patients 20-29 years old. CONCLUSION: In this study, the main etiological agent of viral conjunctivitis in Sapporo, Japan, was Ad; however, attention should be paid to non-adenoviral agents, such as HSV and C. trachomatis, as possible causes of acute conjunctivitis. PMID- 9951640 TI - Immunoelectron microscopic study of the conjunctiva in cicatricial pemphigoid. AB - BACKGROUND: Immune deposits can be found on the conjunctival basement membrane zone of patients affected by cicatricial pemphigoid using immunofluorescence technique. The purpose of this study was to perform direct immunoelectron microscopy on the conjunctiva of patients with scarring conjunctivitis associated with cicatricial pemphigoid. METHODS: Conjunctival and skin biopsies were performed in six patients who presented with presumed autoimmune cicatrizing conjunctivitis associated with cicatricial pemphigoid. Specimens were processed for direct immunofluorescence and direct immunoelectron microscopy. RESULTS: Direct immunofluorescence was positive in all skin samples and in three of six conjunctival samples. Direct immunoelectron microscopy showed immune deposits in the lamina lucida and the lamina densa of all skin and conjunctival samples. CONCLUSIONS: Direct immunoelectron microscopy can be performed on the conjunctiva. It shows the precise localization of cicatricial pemphigoid target antigens within the conjunctival basement membrane zone. PMID- 9951641 TI - Variability of RPE reaction in two cases after selective RPE laser effects in prophylactic treatment of drusen. AB - BACKGROUND: The value of prophylactic photocoagulation of soft drusen is unclear. Photocoagulation is usually performed by a continuous wave laser. METHODS: We report the cases of two patients with age-related macular degeneration with soft drusen who were treated by selective retinal pigment epithelium (RPE) photocoagulation of a pulsed Nd:YLF (527 nm) laser. Laser parameters were: wavelength 527 nm, number of pulses in a train 500, pulse duration 1.7 microseconds, energy per pulse 70 microJ, spot size 160 microns, repetition rate 500 Hz. RESULTS: Dosimetry performed individually showed that in both patients laser photocoagulation was performed at the threshold of RPE disruption. None of the laser effects was visible during photocoagulation. They were detectable only by fluorescein angiography. Despite identical photocoagulation parameters the RPE reaction was completely different. In the first patient RPE hyperpigmentation was notable at most photocoagulation sites and the drusen had disappeared after 6 months. In the second patient the laser effects were not visible after 6 months by biomicroscopy and the drusen stayed unchanged. CONCLUSION: These findings could reflect different repair mechanisms of the RPE after alteration and could represent a sign of a different viable stage in the life of RPE cells. Close attention should be paid to this phenomenon in the various drusen studies currently under way. PMID- 9951642 TI - Macular translocation for surgical management of subfoveal choroidal neovascularizations in patients with AMD: first results. AB - BACKGROUND: At present no satisfying treatment for subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) is available. Visual results after successful surgical removal of subfoveal CNV are disappointing. This has been explained by a primary dysfunction of the retinal pigment epithelium (RPE) in the macular region and the surgical trauma to the RPE in patients with AMD. Therefore, Machemer and Steinhorst developed a technique for macular translocation after surgical removal of subfoveal CNV. We report our first experiences with this technique in patients with subfoveal CNV secondary to AMD. METHODS: Seven patients aged between 71 and 83 years with subfoveal CNV were included in the study. Visual acuity of the fellow eyes was below 20/400. All patients underwent pars plana vitrectomy. Retinal detachment was produced by subretinal infusion of balanced salt solution and a 360 degrees retinotomy at the base of the vitreous was performed. After removal of the CNV, retinal rotation and reattachment, the retina bordering the retinotomy was coagulated with endolaser photocoagulation. Silicone oil was used as temporary tamponade. RESULTS: In all patients the subfoveal CNV was removed and the macula was translocated by a 15 degrees-45 degrees rotation onto functional RPE. The mean duration of follow-up was 11 +/- 3 months. Initial visual acuity ranged from 20/80 to hand movements. Final visual acuity was 20/100 to 20/400. Initially all patients complained of tilted vision. During follow-up the rotation of the image regressed and was well tolerated by all patients. Complications included the development of retinal detachment in three patients after silicone oil removal, development of a macula pucker, and a significant increase of lens opacity in the phakic eyes. CONCLUSION: In our series rapid improvement of visual function was observed in one patient only, even if the macula appeared ophthalmoscopically and angiographically normal. Vitreoretinal complications occurred frequently during follow-up. PMID- 9951643 TI - Effects of EGb761 and superoxide dismutase in an experimental model of retinopathy generated by intravitreal production of superoxide anion radical. AB - BACKGROUND: A study was carried out to investigate the effect of two antioxidants -Ginkgo biloba extract (EGb761) and superoxide dismutase (SOD)--in an experimental model of vitreoretinopathy obtained by direct production of oxygen free radicals in the vitreous cavity. METHODS: Twenty-eight pigmented rabbits were used. Vitreoretinopathy was induced by intravitreal injection of 50 microliters of a mixture composed of 40 nmol of xanthine and 0.001 IU of xanthine oxidase. Rabbits were randomly distributed into four groups: Group 1 (n = 8) did not receive any treatment and served as a positive control. Groups 2 (n = 8) and 3 (n = 8) received for 1 month EGb761 given orally at a dose of 100 mg/kg/day, respectively 1 day after and 1 week before induction of retinopathy. Group 4 (n = 4) was treated by three intramuscular injections of 15,000 IU/kg of SOD, 24 h before induction and 24 and 48 h thereafter. Clinical evaluations and electroretinograms (ERG) were repeatedly performed until the animals were killed at day 28. Histological examinations and immunohistological procedures were performed to ascertain the origin and characteristics of the cellular proliferation and to compare vitreoretinal structures in the four groups. RESULTS: Intravitreal injection of xanthine-xanthine oxidase produced a strong inflammatory response with vitreous infiltrates and epiretinal membrane formation, inconstantly associated with retinal detachment. ERG showed a decrease of the a-, b- and c-waves beginning within a few hours after injection. Histologic evaluation found an intravitreal and epiretinal infiltration by leukocytes and epithelial-derived cells, dense vitreoretinal membranes and retinal detachments with occasional neovascularization. In the treated groups (groups 2-4), all clinical, electric and histologic data were significantly improved compared to the control group. However, no difference could be found among the three treated groups. CONCLUSION: This study demonstrates the strong pathologic effects of free radical production on the retina and the close relationships between free radicals, inflammatory pathways and vitreoretinal proliferative disorders. It also confirms the pharmacological interest of prevention by antioxidants and free radical scavengers. PMID- 9951644 TI - Retinal pigment epithelial cells from Royal College of Surgeons dystrophic rats can take up melanin granules. AB - BACKGROUND: Many successful pigment epithelium transplantation studies involving pink-eyed Royal College of Surgeons (RCS) dystrophic rats showed highly pigmented transplanted cells forming a double layer with slightly pigmented cells, attached to Bruch's membrane. Since it is not clear whether transplanted pigmented cells can displace retinal pigment epithelial (RPE) host cells from Bruch's membrane, we suggested that RPE cells of RCS dystrophic rats can phagocytize melanin granules, possibly derived from perished transplanted cells. METHODS: In a series of three experiments, RPE cells of nine pink-eyed, 2 1/2-month-old RCS dystrophic rats were isolated by trypsinization and mechanical dissection and cultivated in Dulbecco's modified Eagles' medium. These cells were then fed with melanin granules, isolated from bovine RPE cells, double-trypsinized after phagocytosis and viewed by light and electron microscopy. We also transplanted iris pigment epithelial (IPE) cells of 20-day-old Long-Evans rats into the subretinal space of pink-eyed RCS dystrophic rats of the same age, shown in light-microscopic photography after 42 days. RESULTS: Living RPE cells were heavily pigmented after feeding with isolated melanin granules in all three experiments as viewed by light microscopy. In addition, we identified melanin granules phagocytized by dystrophic RPE cells in electron microscopy. After transplantation of pigmented IPE cells into the subretinal space of pink-eyed RCS dystrophic rats' eyes, a layer of slightly pigmented cells was seen on Bruch's membrane below the transplanted IPE cells, shown in light microscopy. CONCLUSION: We have shown by phagocytosis assay that dystrophic RPE cells can take up melanin granules in vitro. Our results assume that pigmented cells in transplantation studies, found as a monolayer, attached to Bruch's membrane, cannot automatically be identified as transplanted cells. Instead, the possibility of perished transplanted cells serving as melanin donors for RPE host cells must be taken into consideration. PMID- 9951645 TI - Inhibitory effect of Trapidil on the proliferation of bovine corneal fibroblasts in vitro. AB - BACKGROUND: In order to develop new strategies for the pharmacological modulation of posttraumatic and postsurgical wound healing of the corneal stroma, the effect of Trapidil, a competitive platelet-derived growth factor (PDGF) antagonist, on the proliferation of cultured bovine stromal fibroblasts (BSF) was investigated. METHODS: BSF, obtained from explant cultures, were seeded at a cell density of 100/mm2. The effect of various concentrations of Trapidil on cell viability and cell proliferation was determined using three different culture conditions: (1) serum-free medium (WM/F12), (2) serum-containing medium (WM/F12 + 10% FCS), and (3) serum-free medium + 50 ng/ml PDGF-BB. Trapidil was added in concentrations ranging from 100 micrograms/ml to 400 micrograms/ml. Cell numbers were determined 2 and 5 days after addition of Trapidil, using a computer-based cell-counting system. Cell viability was evaluated morphologically and by means of a repopulation assay. RESULTS: Addition of Trapidil (100-400 micrograms/ml) led to a significant, dose-dependent inhibition of both serum- and PDGF-BB-induced proliferation of BSF. In contrast, treatment of quiescent BSF, cultured in serum free medium, did not result in a significant reduction of cell number. No cytotoxic effects were observed. CONCLUSION: The results of the present study demonstrate an inhibitory effect of Trapidil on the proliferation of BSF. It can be assumed that application of Trapidil might be a useful tool in the prevention of corneal complications after trauma (e.g., scarring, astigmatism and--with respect to photorefractive procedures--formation of haze and regression of the refractive effect). PMID- 9951646 TI - Appearance and rapid growth of retinal tumor (reactive astrocytic hyperplasia?). AB - BACKGROUND: Tumors of the retina are often seen in association with systemic syndromes such as neurofibromatosis, tuberous sclerosis, and von Hippel-Lindau disease. These masses are either astrocytic hamartomas or capillary hemangiomas. Retinal tumors unassociated with other systemic disease have also been reported. METHODS: The ophthalmologic evaluation and clinical course of a 65-year-old woman who developed an epiretinal membrane followed by a vascularized retinal mass in the macular area are described. RESULTS: Appearance and rapid growth of the lesion were documented with fundus photography and fluorescein angiography. The lesion was treated with photocoagulation following growth that threatened the foveal region. Choroidal neovascularization subsequently developed toward the fovea, and visual acuity has remained poor. After 4 years of follow-up no local recurrence or systemic disease possibly related to the tumor has occurred. CONCLUSIONS: This is the first report of documented appearance and rapid growth of a retinal tumor that resembles a reactive astrocytic hyperplasia. PMID- 9951647 TI - MHC expression in syngeneic and allogeneic retinal cell transplants in the rat. AB - BACKGROUND: The major histocompatibility complexes, MHC class I and II, are found only sparsely or not at all in the retina. Since the eye is immunoprivileged, we decided to investigate how the MHC class I and II antigens were influenced by a retinal transplant and whether this could be correlated to rejection of the transplant. METHODS: Fetal neural retinas of Sprague-Dawley (SD) rats were implanted in the subretinal space of adult Lewis and SD rats. After 5 weeks the retinas and the transplants were evaluated with antibodies against MHC class I and II antigens as well as microglia. RESULTS: In the syngeneic transplants no upregulation of MHC class I antigen was seen and no MHC class II-positive cells could be detected. In the allogeneic transplants, on the other hand, there was marked upregulation of MHC class I antigen. Numerous MHC class II antigen positive cells were seen in the subretinal transplant but also in the host retina. CONCLUSION: Allogeneic retinal transplants seem to grow and thrive just as well as syngeneic transplants, but in the former there is considerable upregulation of MHC expression. Our interpretation of these results is that the allogeneic transplants are recognized as nonself, but that there is also something that modifies this reaction of the immune system at this level, preventing the rejection that would normally ensue. PMID- 9951651 TI - Ethical concerns. PMID- 9951650 TI - Phakic intraocular lenses and patient consent. PMID- 9951649 TI - The human thymus. A chimeric organ comprised of central and peripheral lymphoid components. AB - The human thymus is a lymphoepithelial organ in which T cells develop during fetal life. After maturation and selection in the fetal thymic microenvironment, T cells emigrate to peripheral lymphoid tissues such as the spleen, gut, and lymph nodes, and establish the peripheral T cell repertoire. Although the thymus has enormous regenerative capacity during fetal development, the regenerative capacity of the human postnatal thymus decreases over time. With the advent of intensive chemotherapy regimens for a variety of cancer syndromes, and the discovery that infection with the Human Immunodeficiency Virus (HIV) leads to severe loss of CD4+ T cells, has come the need to understand the role of the human thymus in reconstitution of the immune system in adults. During a recent study of the thymus in HIV infection, we observed many CD8+ T cells in AIDS thymuses that had markers consistent with those of mature effector cytotoxic T cells usually found in peripheral immune tissues, and noted these CD8+ effector T cells were predominantly located in a thymic zone termed the thymic perivascular space. This article reviews our own work on the thymus in HIV-1 infection, and discusses the work of others that, taken together, suggest that the thymus contains peripheral immune cell components not only in the setting of HIV infection, but also in myasthenia gravis, as well as throughout normal life during the process of thymus involution. Thus, the human thymus can be thought of as a chimeric organ comprised of both central and peripheral lymphoid tissues. These observations have led us to postulate that the thymic epithelial atrophy and decrease in thymopoiesis that occurs in myasthenia gravis, HIV-1 infection, and thymic involution may in part derive from cytokines or other factors produced by peripheral immune cells within the thymic perivascular space. PMID- 9951652 TI - Harold Ridley's first patient. PMID- 9951653 TI - Sulcus transscleral sutured posterior chamber lenses. PMID- 9951654 TI - Determining real IOP values. PMID- 9951655 TI - Consolidating the association between Goldmann applanation IOP undermeasurement and photorefractive surgery. PMID- 9951656 TI - Phakic IOL terminology. PMID- 9951657 TI - Inclusive references. PMID- 9951658 TI - Consultation section. Cataract surgical problem. PMID- 9951659 TI - Dispersive-cohesive viscoelastic soft shell technique. AB - Based on their physical properties, ophthalmic viscoelastic agents can be divided into 2 groups: higher-viscosity cohesive and lower-viscosity dispersive. Higher viscosity cohesive agents are best at creating and preserving space, while lower viscosity dispersive agents are retained better in the anterior chamber and are capable of partitioning spaces. The viscoelastic soft shell technique maximizes the advantages and minimizes the disadvantages of both groups by using dispersive and cohesive agents together in sequence based on the desired surgical goal. PMID- 9951660 TI - The 45 degree tilt: improvement in surgical ergonomics. AB - The ergonomics of ocular surgery has received little attention even though the usual positioning of the patient and surgeon during traditional cataract surgery places the surgeon at risk for back, neck, and arm strain. The recent development of the temporal cataract incision allows the operating microscope to be tilted and the patient's head to be turned 45 degrees, permitting the surgeon to assume better posture during ocular procedures. The 45 degree tilt helps the surgeon avoid cervical and lumbar flexion by leaning back in the chair, which produces cervical and lumbar extension and avoids repetitive stress injuries to the neck and lower back. PMID- 9951648 TI - The immunopathology of siliconosis. History, clinical presentation, and relation to silicosis and the chemistry of silicon and silicone. AB - Recent evidence confirms the fundamental involvement of the human immune system in the reaction to implantation of silicone-based medical devices. An as yet-to be particularized epitope of many complex substances sharing siloxane structures is presented through the MHC-II apparatus with development and retention of T cell memory. This memory can be tested for in practical terms using one or more forms of silica, which links the immuno-histopathology and autoimmune attributes of "silicosis" with those of "siliconosis." The lesions of siliconosis are typical of those for persistent antigens and delayed, cell mediated hypersensitivity. The basic descriptive pathology of the reaction to silicone has been known since soon after introduction of silicones in medical procedures, with the exception of some details related to the more recent discoveries on the role of cytokines in the immunopathic process. The clinical consequences of siliconosis are common and can be severe in some individuals implanted with silicone devices. PMID- 9951661 TI - Binocular function and patient satisfaction after monovision induced by myopic photorefractive keratectomy. AB - PURPOSE: To measure binocular function and patient satisfaction with monovision induced by photorefractive keratectomy (PRK) in myopic presbyopic patients. SETTING: Refractive Department, Cleveland Clinic, Cleveland, Ohio, USA. METHODS: This study comprised 21 myopic presbyopic patients with monovision induced by PRK. Sixteen emmetropic patients who had PRK served as a control group. Monovision was induced by undercorrecting the nondominant eye by 1.25 diopters for near vision and correcting the dominant eye with emmetropia for distance vision. Monocular and binocular uncorrected Snellen visual acuities at 20 feet and 13 inches, manifest refraction, ocular dominance, stereopsis at 20 feet and 13 inches, monocular and binocular contrast sensitivities, Worth-4-Dot test at 20 feet and 1/3 of a meter, and fusional convergence amplitudes were examined in each patient. RESULTS: In the monovision group at near and distance, 20 patients (95.3%) had binocular visual acuity of 20/25 or better. No patient in the monovision group used reading glasses postoperatively; 4 of 16 patients (25.0%) in the control group used such glasses. All patients maintained binocular fusion and stereo acuity ranging from 40 to 800 seconds of arc. Mean patient satisfaction was 86% (range 40% to 100%). In the control group, 12 patients (75.0%) had binocular distance visual acuity of 20/25 or better and 11 (68.8%) had binocular near visual acuity of 20/25 or better. CONCLUSION: Monovision PRK patients had better near vision than control PRK patients, with minimal compromise in stereo acuity and overall high patient satisfaction. PMID- 9951662 TI - Induced astigmatism after photorefractive keratectomy. AB - PURPOSE: To retrospectively analyze a group of patients to determine whether their induced astigmatism was caused by asymmetry in the laser beam, asymmetry in ablation rates, or wound healing in different corneal meridians. SETTING: Single center physician office. METHODS: In this study, 146 eyes of 116 patients who had photorefractive keratectomy (PRK) for myopia with the Apex laser (Summit Technology) were retrospectively identified. In 28 eyes, the patient's chair had been rotated 90 degrees from its usual position under the laser. The vector summated mean change in astigmatism in eyes with the chair rotated 90 degrees was compared with that in a group of control eyes in which the chair was in the usual position. RESULTS: The vector-summated mean change in the control eyes was 0.30 diopter (D) at 83 degrees. Forty-eight of 113 eyes (42.5%) had induced with-the rule (WTR) astigmatism, and 14 of 113 eyes (12.4%) had induced against-the-rule (ATR) astigmatism. In the eyes in which the chair was rotated 90 degrees, vector summated mean change was 0.10 D at 13 degrees (P < .0005). One of 27 eyes (3.7%) had induced WTR astigmatism, and 13 of 27 eyes (48.1%) had induced ATR astigmatism (P < .001, chi-square). CONCLUSION: Astigmatism induced by myopic PRK with the Apex laser was small. The axis of induced astigmatism rotated 90 degrees when the patient's chair was rotated, implying that it is inhomogeneities in the beam rather than meridional asymmetry in ablation rates or wound healing that are responsible for induced astigmatism. PMID- 9951663 TI - Retreatment of central islands after photorefractive keratectomy. AB - PURPOSE: To evaluate excimer laser retreatment of central islands and the refractive consequences. SETTING: Department d'Ophtalmologie, Centre Hospitalier de l'Universite Laval, Quebec City, and Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Canada. METHODS: In this study, 22 eyes retreated for central islands were retrospectively analyzed. All initial corrections and retreatments were performed with the Chiron Technolas Keracor 116 laser. RESULTS: A marked decrease in symptoms was observed in almost all cases. Topographic analysis confirmed these results but revealed persistence of minimal islands in several cases. Retreatment of central islands also induced a small myopic correction. Using a 2.5 mm zone, the mean induced refractive effect was 0.21 diopter of myopic correction per diopter of retreatment. CONCLUSION: Retreatment of central islands appeared safe, was relatively easy, and provided good results with a rapid recovery. PMID- 9951665 TI - Surgical correction of postkeratoplasty astigmatism with the Hanna arcitome. AB - PURPOSE: To report the results of arcuate keratotomy performed with the Hanna arcitome in patients with postkeratoplasty astigmatism. SETTING: Department of Ophthalmology, Saint-Antoine Hospital, Paris VI University, Paris, France. METHODS: This retrospective study comprised 22 eyes (22 patients) with postkeratoplasty astigmatism. Paired symmetrical arcuate keratotomy was performed with the Hanna arcitome. Outcome measures included refraction, videokeratography, and keratometry. RESULTS: At 6.6 months +/- 8.9 (SD) after surgery, the mean increase in best spectacle-corrected visual acuity (BSCVA) was 2.1 +/- 2.4 lines. Thirteen eyes gained 2 lines or more of BSCVA, and 15 gained 3 lines or more of uncorrected visual acuity. Two patients had a decrease in BSCVA: 1 had lens opacification unrelated to arcuate keratotomy and 1, increased corneal irregularity. Mean refractive astigmatism was 6.94 +/- 2.11 diopters (D) preoperatively and 3.85 +/- 1.95 D postoperatively (P < .01). Mean change in keratometric astigmatism was -51 +/- 36%. Astigmatism decreased in 21 eyes as measured by manifest refraction, keratometry, and videokeratography; it increased in 1 cornea with a microperforation. CONCLUSIONS: The results of arcuate keratotomy performed with the Hanna arcitome were comparable to those with freehand relaxing incisions. The instrument made safer and more uniform arcuate incisions than a freehand technique. PMID- 9951664 TI - Excimer laser assisted in situ keratomileusis for hyperopia. AB - PURPOSE: To evaluate hyperopic surgical correction with 6.0 mm optical zone hyperopic laser in situ keratomileusis (LASIK) after various refractive procedures. SETTING: Buzard Eye Institute, Las Vegas, Nevada, USA. METHODS: This study followed 14 eyes of 14 patients who had hyperopic LASIK with a VISX Star laser. Mean follow-up was 8 months. The patients represented a variety of preoperative situations, including primary radial keratotomy (RK) (5 eyes) primary automated lamellar keratectomy (ALK) (2 eyes), primary LASIK (3 eyes), congenital hyperopia (1 eye), and combinations of ALK, RK, and LASIK. In all patients, a toroidal or "doughnut-shaped" ablation was constructed with the use of a 3.5 mm diameter soft contact lens as a blocking agent centrally with a 6.0 mm outside beam diameter. RESULTS: Mean preoperative spherical equivalent was +1.33 diopters (D) +/- 0.5 (SD) (range +0.50 to +1.88 D). The mean spherical equivalent was -0.32 +/- 1.20 D (range -1.25 to +2.63 D) at 1 month postoperatively and -0.15 +/- 0.60 D (range -1.13 to +1.25 D) at the last follow up. Uncorrected visual acuity of 20/40 was obtained by 13 eyes (93%). No eye lost 2 or more lines of best corrected visual acuity at last follow-up. Four eyes required a postoperative LASIK enhancement procedure to correct induced myopia. No significant complications were seen. CONCLUSION: Hyperopic LASIK with the technique used in this study appeared safe, predictable, and stable. It represents a simple way to add hyperopic correction to existing laser systems. PMID- 9951666 TI - Laser thermokeratoplasty after lamellar corneal cutting. AB - PURPOSE: To evaluate the effect of laser thermokeratoplasty (LTK) in eyes that previously had a lamellar corneal cut. SETTING: University of Al-Azhar, Cairo, Egypt, and Instituto Oftalmologico de Alicante, Spain. METHODS: In 15 eyes (10 patients), noncontact LTK was applied 6 to 8 weeks after a lamellar corneal cut had been made. Central pachymetry, keratometry, and videokeratography were performed and uncorrected visual acuity, best spectacle-corrected visual acuity (BSCVA), and manifest and cycloplegic refractions measured before and 1, 6, 12, and 18 months after LTK. RESULTS: Mean follow-up was 19.13 months. Mean refraction was +5.93 diopters (D) +/- 1.9 (SD) before LTK and -0.43 +/- 1.5 D at 1 month, +1.63 +/- 1.6 D at 6 months, 1.91 +/- 1.41 at 12 months, and +2.01 +/- 1.5 D at the end of the study. Total regression did not occur in any case. Mean BSCVA before LTK was 0.66 +/- 0.2, and spontaneous visual acuity at the end of the study was 0.58 +/- 0.18. No patient lost any lines of preoperative BSCVA. There was no significant difference between the results at 12 months and at the end of the study. CONCLUSION: Corneal lamellar cutting appeared to improve the magnitude of the refractive effect of noncontact LTK and to decrease the amount of regression. PMID- 9951667 TI - Pathological examination of an explanted phakic posterior chamber intraocular lens. AB - PURPOSE: To report the clinicopathological correlation of an explanted phakic posterior chamber intraocular lens (PPC IOL) and to study the conformation of this lens implanted into human eyes obtained postmortem. SETTING: Center for Research on Ocular Therapeutics and Biodevices, Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA. METHODS: Three silicone PPC IOLs were explanted. One lens, explanted from a 38-year-old woman with complicated cataract, was submitted for pathological analysis. In addition to gross and scanning electron microscopy (SEM), the lens was studied after experimental implantation in human eyes obtained postmortem using frontal, posterior, and side-view techniques. RESULTS: Although gross and SEM showed that the IOL was well polished, examination of the lens in human cadaver eyes showed it was oversized and poorly fixated. It was relatively bulky in its anterior-posterior dimension and revealed evidence of significant contact with the iris and crystalline lens. CONCLUSIONS: This study illustrates many pitfalls to be avoided in the design of a plate PPC IOL. The lens in this report was too large, and instead of ciliary sulcus fixation, it showed poor fixation through the zonules onto the posterior face of the pars plicata. Present and future PPC IOLs should be submitted for similar preclinical studies to clarify the type and site of fixation. PMID- 9951668 TI - Necessity of the Honan intraocular pressure reducer in cataract surgery using topical anesthesia. AB - PURPOSE: To assess the use of the Honan intraocular pressure reducer (HIPR) for clear corneal cataract surgery using topical anesthesia. SETTING: University of North Carolina Hospitals Ambulatory Care Clinic outpatient operating rooms. METHODS: Of 51 consecutive candidates for surgery (excluding those with uncontrolled glaucoma), 26 were randomly assigned to wear the HIPR (Honan group) for 10 minutes before surgery. The remainder were placed in a control group. Intraocular pressure (IOP) was measured before (T1) and after (T2) HIPR application and after patient preparation for surgery (T3). RESULTS: Mean IOP was the same in the Honan and control groups at T1 and T3. At T2, the groups had a significantly different mean IOP (P = 1.8 x 10(-5)). In the Honan group, mean IOP decreased significantly (P = 2.8 x 10(-7)) between T1 and T2, and there was a significant correlation among patients at T1 and T2 (P < .0005). Between T2 and T3, the Honan group experienced a significant recovery (P = 3.5 x 10(-9)); there was a significant correlation between the decreases from T1 to T2 and the increases from T2 to T3 (P < .0005). Mean IOP in the control group did not change between T1 and T2 but increased significantly between T2 and T3 (P = .004). CONCLUSION: When using topical anesthesia, the HIPR transiently reduced IOP. However, the IOP-reducing effect resolved by the time of surgery, negating any reason to use the HIPR with topical anesthesia for cataract surgery. PMID- 9951669 TI - Inflammation after phacoemulsification in patients with type 2 diabetes mellitus without retinopathy: prospective study. AB - PURPOSE: To evaluate inflammation after clear corneal incision (CCI) cataract surgery in patients with noninsulin-dependent diabetes mellitus and no retinopathy. METHODS: Forty patients with diabetes and 40 age-matched controls had standardized temporal CCI cataract surgery with implantation of a foldable intraocular lens. Anterior chamber flare was evaluated in an undilated eye with a laser flare-cell meter preoperatively and 1, 3, 7, 14, and 28 days postoperatively. RESULTS: In both groups, flare and cell values increased on the first postoperative day and successively decreased on the following days. Flare had not recovered to preoperative values by day 28. At no time was there a significant mean difference in cell and flare between the 2 groups. CONCLUSION: It does not appear necessary to alter the postoperative therapeutic regimen in patients with type 2 diabetes mellitus and no retinopathy. PMID- 9951670 TI - Posterior capsule opacification after phacoemulsification in patients with diabetes mellitus. AB - PURPOSE: To compare posterior capsule opacification (PCO) after phacoemulsification and implantation of heparin-surface-modified (HSM) poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) in the capsular bag in patients with diabetes mellitus with that in a control group. SETTING: St. Erik's Eye Hospital, Stockholm, Sweden. METHODS: This prospective study comprised 26 patients with diabetes mellitus and 26 control patients without diabetes. Those with glaucoma, exfoliation syndrome, uveitis, and pupil size smaller than 6.0 mm after dilation were excluded. All patients received the same standardized phacoemulsification procedure with implantation of an HSM PMMA IOL in the capsular bag. Posterior capsule opacification was scored 1 and 2 years after surgery by evaluating retroillumination images taken with a Scheimpflug camera (Nidek Anterior Eye Segment Analysis System) after pupil dilation with phenylephrine 10% and cyclopentolate 1%. The PCO density behind the IOL optic was graded clinically from 0 to 4 (0 = none, 1 = minimal, 2 = mild, 3 = moderate, 4 = severe) and scored using the Evaluation of Posterior Capsule Opacification medical software developing system. RESULTS: No differences in PCO were found between the diabetic and control groups 1 year after surgery. The total PCO score was significantly less in diabetic than in control eyes 2 years after surgery (P < .05, Mann-Whitney). In addition, progression of PCO from 1 year to 2 years after surgery was significantly less in diabetic groups with different stages of diabetic retinopathy than in the control group (P < or = .05, Kruskal-Wallis analysis of variance and multiple comparisons). CONCLUSION: The rate of PCO after phacoemulsification was statistically significantly lower in patients with diabetes mellitus than in those without diabetes. PMID- 9951671 TI - Phacoemulsification in eyes with posterior polar cataract. AB - PURPOSE: To evaluate the results of phacoemulsification in eyes with posterior polar developmental cataract and to appraise the strategy for surgical management. SETTING: Iladevi Cataract & IOL Research Centre, Raghudeep Eye Clinic, Ahmedabad, India. METHOD: This prospective study comprised 25 consecutive patients. All surgeries were performed by 1 surgeon. Endophacoemulsification was carried out after hydrodelineation. Hydrodissection or rotation was not attempted. A 2-port vitrectomy was performed when necessary. RESULTS: Mean follow up was 13.72 months (range 7 to 22 months). Nine patients (36%) developed posterior capsule rupture and 8 (32%) revealed plaques. An intraocular lens (IOL) was implanted in all 25 eyes. In 8 of 9 cases with rupture, the haptics were placed in the sulcus; in 1 case, the IOL was placed in the bag. One patient in the capsular rupture group developed macular edema 3 weeks postoperatively that responded to conservative treatment. Among 25 patients, 18 had a visual acuity of 20/20 to 20/30 and 6, 20/80 to 20/120. These 6 patients had residual posterior capsule plaque. All except 2 patients with plaque required a neodymium:YAG capsulotomy. In these patients, visual acuity improved to 20/30. In 1 patient, with microcornea, acuity did not improve to beyond 20/120. CONCLUSION: This study confirms the predisposition to posterior capsule rupture in eyes with posterior polar cataracts. Careful surgical planning produces satisfactory technical and visual outcomes. PMID- 9951672 TI - Posterior capsule opacification 5 years after extracapsular cataract extraction. AB - PURPOSE: To find out whether there is a "hidden" group of patients with posterior capsule opacification (PCO) 5 years after cataract surgery and to establish the incidence of PCO. SETTING: Department of Ophthalmology, Sahlgrenska University Hospital, Gothenburg, Sweden. METHODS: A random sample (n = 164) was selected among patients who had extracapsular cataract extraction (ECCE) with intraocular lens implantation in 1991 (N = 1672). All surgically treated cases that required neodymium:YAG (Nd:YAG) laser capsulotomy (n = 37) within the first 5 years after surgery were recorded. Patients still alive 5 years after surgery who had not had Nd:YAG treatment were offered an eye examination to determine whether PCO requiring capsulotomy existed. RESULTS: Thirty-seven of 110 patients (34%) alive 5 years after surgery had an Nd:YAG capsulotomy during the first 5 postoperative years. Follow-up was possible in 51 of 73 untreated patients (70%). Clinically significant PCO according to specified criteria was found in 7 cases (14%). Half of them would benefit from treatment; the other half had visual impairment from other eye disease. CONCLUSIONS: The estimated incidence of PCO 5 years after ECCE was 43%. Five years after surgery, there was an untreated group with clinically significant PCO, approximately 9% of the surgically treated population. This hidden group must be considered in PCO studies. PMID- 9951673 TI - Posterior capsule opacification in eyes with a silicone or poly(methyl methacrylate) intraocular lens. AB - PURPOSE: To evaluate the effect of poly(methyl methacrylate) (PMMA) and silicone intraocular lenses (IOLs) on posterior capsule opacification (PCO) after cataract surgery. SETTING: Kangnam St. Mary's Hospital, Seoul, Korea. METHODS: This retrospective study comprised 48 patients (54 eyes) who had neodymium:YAG (Nd:YAG) laser posterior capsulotomy from March 1995 to December 1997. All operations were performed by 1 surgeon using the same technique except for incision method. RESULTS: Mean interval from cataract surgery to Nd:YAG capsulotomy was 31 months in the PMMA group and 15 months in the silicone group. The difference between groups was statistically significant (P = .0002). The ratio of Elschnig pearl to fibrosis type PCO was 16:6 in the PMMA group and 14:18 in the silicone group. Mean total Nd:YAG laser energy used was 256 mJ in the PMMA group and 309 mJ in silicone group. However, the damage caused by the laser was more severe and more common in the silicone group. CONCLUSION: Silicone IOLs induced PCO faster than PMMA IOLs, with fibrosis the most common type in the silicone group. Precautions should be taken to prevent damage during Nd:YAG laser capsulotomy in eyes with a silicone IOL. PMID- 9951674 TI - Optical coherence tomography of macular thickness after cataract surgery. AB - PURPOSE: To evaluate macular thickness changes after uneventful cataract surgery using optical coherence tomography (OCT) and compare the findings with those of flare and cell measurements of the anterior chamber. SETTING: Clinique Sourdille, Nantes, France. METHODS: In this retrospective study, 41 eyes having uneventful cataract surgery with a clear corneal small incision and intracapsular fixation of a foldable intraocular lens were evaluated by OCT and laser flare and cell measurements preoperatively and 1, 8 to 12, and 30 to 60 days postoperatively. RESULTS: Some postoperative increase in macular thickness was noted in 11 eyes. This was not related to a higher postoperative flare. Visual consequences were proportional to the macular elevation. CONCLUSION: Clinical and subclinical thickness changes, without breakdown of the blood-aqueous barrier, can be detected after cataract surgery. Most of these changes resolve spontaneously, but their mid- and long-term significance is unknown. PMID- 9951676 TI - Intralenticular implant study in pigmented rabbits: opacity lensmeter assessment. AB - PURPOSE: To quantitatively analyze the clarity of regenerated lens material after endocapsular lens extraction and restoration of the lens capsular bag with and without implantation of an intralenticular disc lens. SETTING: Shepherd Research Center, Allergan, Irvine, California, USA. METHOD: The clarity of regenerated lens material was evaluated by Interzeag Opacity Lensmeter 701 (OLM) recordings after endocapsular lens extraction in New Zealand/Dutch Belt pigmented rabbits with (n = 21) and without (n = 16) placement of a disc-shaped intralenticular implant in the capsular bag. Postoperative objective measurements were performed at 1, 2, and 3 weeks and 1, 2, 3, and 6 months. Comparisons were made between young and adult rabbits. RESULTS: Mean OLM results were similar in both groups at weeks 1, 2, 3, and 4. After 1 month, progressive central compaction of early irregular regenerated lens fibers was associated with increased OLM readings that were higher in the intralenticular implant group than in the control group. Regenerated lens opacification was greater in tissue posterior to the intralenticular lens than in that anterior to the disc lens. CONCLUSION: Insertion of an intralenticular disc lens into the lens capsule bag was associated with poor optical clarity primarily of the posterior regenerated lens tissue. The OLM was useful in assessing the degree of opacification of the regenerated lenses. PMID- 9951675 TI - Pseudoaccommodation: BioComFold versus a foldable silicone intraocular lens. AB - PURPOSE: To assess the degree of pseudoaccommodation amplitude correlated with shifts along the anteroposterior axis of the BioComFold foldable intraocular lens (IOL). SETTING: Department of Ophthalmology, Hotel-Dieu Hospital, Paris, France. METHODS: This prospective study comprised 30 eyes of 30 patients operated on consecutively for cataract by phacoemulsification and in-the-bag implantation of a BioComFold (15 patients) or a foldable control (15 patients) IOL. The BioComFold IOL has a peripheral bulging ring that pushes the optic forward during the effort to accommodate, creating a zoom effect. Pseudoaccommodation amplitude was evaluated using the blurring of controlled vision by adding spheres, with the best correction for distance vision in place. Pupil diameter was measured with a Goldmann campimeter under constant illumination. Anterior chamber depth was determined by A-scan (Paxial, Biophysic Medical) 30 minutes after cyclopentolate 1% was instilled and again 30 minutes after pilocarpine 2% was instilled. RESULTS: The difference in pseudoaccommodation amplitude and pupil diameter between the 2 groups was not statistically significant (P = .6737 and P = .4014, respectively). The IOL's forward shifts from maximal ciliary relaxation to maximal ciliary contraction were significantly greater in the BioComFold group (P = .0215). CONCLUSION: The design of the BioComFold IOL allowed greater forward optic shifts along the anteroposterior axis during the effort to accommodate. Nevertheless, this shift was not correlated with a significantly greater pseudoaccommodation amplitude. PMID- 9951677 TI - Cataract development after implantation of the Staar Collamer posterior chamber phakic lens. AB - Implantation of a posterior chamber phakic intraocular lens is an effective refractive procedure with a good safety record in the short-term follow-ups reported in the literature. Cataract formation is a potential complication of the procedure. Two patients developed lens opacities in 3 eyes after the procedure was performed for myopic astigmatism. The possible causes are discussed. This is not a dangerous complication as cataract extraction is easily achieved if necessary. However, it is undesirable and further research is required to assess the long-term incidence, causes, and ways to prevent its occurrence. PMID- 9951678 TI - Late clear corneal wound failure after trivial trauma. AB - A clear corneal cataract wound ruptured after trivial trauma. The wound did not meet the criteria for wound stability as previously recommended. This case illustrates the potential public health hazard with the increasing use of clear corneal cataract surgery. Proper wound design can eliminate this risk. Patients without proper wound design should be cautioned to wear protective eyewear to avoid serious or blinding trauma. PMID- 9951679 TI - Combined surgery for severe eye trauma with extensive iridodialysis, posterior lens dislocation, and intractable glaucoma. AB - A 44-year-old woman sustained a severe left eye contusion from the explosion of a plastic bottle containing fermented orange juice. This resulted in extensive iridodialysis, posterior crystalline lens dislocation, and intractable glaucoma. Eleven days after the injury, combined surgery of trabeculectomy with mitomycin C, pars plana vitrectomy, lens removal, iridodialysis repair, and scleral-fixated intraocular lens implantation under general anesthesia was performed. Intraocular pressure (IOP) was under control until 5 weeks postoperatively; glaucoma implant surgery was then performed. At the last follow-up 15 months after the combined surgery, best corrected visual acuity was 20/50 and IOP was 15 mm Hg without medication. Combined surgery can be considered a safe, effective option in the management of severe eye trauma in selected cases. PMID- 9951680 TI - Spontaneous dislocation into the vitreous of a poly(methyl methacrylate) disc lens 9 years after surgery. AB - A 76-year-old woman had sudden visual loss 9 years after an extracapsular cataract extraction with implantation of a poly(methyl methacrylate) disc intraocular lens (IOL) in the capsular bag. Slitlamp examination showed the disc IOL had luxated into the vitreous through a linear inferior opening in the capsular bag; the IOL lay on the retinal surface. A pars plana vitrectomy was performed. The vitreous cavity was filled with perfluorocarbon liquid, floating the IOL to behind the iris. The IOL was removed through a limbal incision, then another type of IOL was implanted in the ciliary sulcus using transscleral fixation. Thirty days after surgery, best corrected visual acuity (BCVA) was 20/20. At 2 months, total retinal detachment appeared with a large superior retinal dialysis. Another pars plana vitrectomy was performed and the scleral fixated IOL removed through a limbal incision. Internal gas tamponade was used. The eye was left aphakic. Final BCVA was 20/25. PMID- 9951681 TI - Capsular bag distension after optic capture of a sulcus-fixated intraocular lens. AB - Capsular bag distension from occlusion of the circular anterior capsule opening by the intraocular lens (IOL) optic is a rare complication of capsulorhexis. The nature and source of fluid remain unclear. We report a case of capsular bag distension in an eye with an optic-captured, all-poly(methyl methacrylate), sulcus-fixated IOL. The fluid behind the IOL optic was visible on the first postoperative day and resolved spontaneously by the sixth postoperative week. We believe that retained viscoelastic material in the capsular bag was a major contributor to the fluid. PMID- 9951682 TI - Oligoclonal T cells in human cancer. AB - Many solid tumors are characterised by the infiltration of lymphocytes and their presence has been correlated with a more favourable prognosis. These tumor infiltrating lymphocytes (TIL), have been shown to possess specific cytolytic reactivity towards autologous tumours, thus suggesting that tumour cells may express antigens capable of eliciting an immune response. Expression of such tumour-associated antigens (TAA) in combination with appropriate accessory signals would lead to the in vivo accumulation of T cells with anti-tumour specificity. Analysis of the composition of the specific T-cell receptor (TCR) of TIL could thus provide information on the nature of the antigen(s) recognised by TIL. In this review, different aspects of the presence of clonal T cells in patients with cancer are discussed. PMID- 9951683 TI - Monoclonal antibodies in solid tumours: approaches to therapy with emphasis on gynaecological cancer. AB - Monoclonal antibodies have progressed from the laboratory to the clinic. Although recognised in diagnosis there are still problems as far as their therapeutic use is concerned. This review looks at the history, principles of active specific immunotherapy, clinical experience with monoclonal antibodies in therapy of solid tumours, in particular the development of new bispecific monoclonal antibodies, and trials in ovarian, breast and colorectal cancer. Immunoconjugates, linked with radionuclides and cytotoxic drugs, indicate future developments. Conditions for successful therapy, especially with adjuvants in patients with small tumour residues, are also described. PMID- 9951684 TI - New p53-based anti-cancer therapeutic strategies. AB - The p53 gene is frequently mutated in human tumours and therefore an important target for therapeutic intervention. Several p53-based strategies for treatment of cancer are currently under development. p53 gene therapy has resulted in tumour regression in patients with lung cancer. A mutant adenovirus can obliterate tumour cells carrying mutant p53 or lacking p53, but is unable to replicate in normal cells. Furthermore, current studies suggest that reactivation of mutant p53 proteins in tumours using small p53-activating molecules may initiate p53-dependent apoptosis and thus eliminate the tumour. PMID- 9951686 TI - Apoptosis in B-chronic lymphocytic leukaemia. AB - B-chronic lymphocytic leukaemia (B-CLL) is characterised by the progressive accumulation of monoclonal B cells, which may be the result of several factors leading to extended B-CLL cell lifespan, increased proliferative capacity and diminished cell death. Here we review the implications of several signals mediated by receptors, such as surface IgM, CD6 and CD40, for the B-CLL cell survival, together with data on gene modulation in relation to the apoptosis process in B-CLL cells. We also describe some features of the Fas/FasL system in B-CLL that hypothetically might contribute to the accumulation of leukaemic cells and the progression of the disease, by downregulating the apoptotic response or avoiding the autologous immune response. PMID- 9951685 TI - Glycosylated and non-glycosylated recombinant human granulocyte colony stimulating factor (rhG-CSF)--what is the difference? AB - Two forms of recombinant human G-CSF (rhG-CSF) are available for clinical use: filgrastim is expressed in E coli and non-glycosylated, whereas lenograstim is derived from Chinese hamster ovary (CHO) cells and glycosylated. The function of the sugar chain, accounting for approximately 4% of the molecular weight of lenograstim (and native G-CSF), is not known. Glycosylation of the G-CSF molecule does not prolong its circulation half life. Lenograstim is more active than filgrastim (and research-use deglycosylated G-CSF) on a weight-by-weight basis in in vitro colony-forming and cell line assays. An international potency standard assigns a specific activity of 100,000 IU/microgram to filgrastim and 127,760 IU/microgram to lenograstim. Correspondingly, two randomised crossover studies in normal subjects, comparing mass equivalent doses of the two rhG-CSFs, have demonstrated a 25-30% higher concentration of blood stem cells (CD34+, CFU-GM) during lenograstim administration. No difference in side effects was observed. Results from a prospective, randomised, non-crossover trial in breast cancer patients suggest that bioequivalent doses of filgrastim and lenograstim have a similar effect on mobilisation of CD34+ cells and immature CD34+ cell subsets, respectively. Although comparisons outside the setting of stem cell mobilisation are lacking, the clinical relevance of the greater specific activity of lenograstim may thus be limited. The difference in potency between microgram identical doses of the two rhG-CSFs makes dosing in biological units (IU) rather than mass units (microgram) more appropriate. PMID- 9951687 TI - Breast cancer in the eastern province of Saudi Arabia. AB - In the Kingdom of Saudi Arabia (KSA), hospital and population based statistics have shown that breast cancer has the highest crude frequency rate among Saudi women. The scarcity of reports about the disease in the KSA has been the impetus to this analysis about breast cancer in the eastern province of KSA. Data on female patients with invasive breast carcinoma seen at King Fahd Hospital of the University in the eastern province of KSA, were retrospectively reviewed. The analysis intended to examine the pattern of the disease and the outcome for patients. Between 1985 and 1995, 292 patients were identified. Their median age +/- SD (standard deviation) was 42 +/- 10.5 years. Most patients were younger than 50 years (78%) and were predominantly premenopausals (79%). Only 25 (9%) of patients had stage I cancer, whilst 130 (44%), 90 (30%), and 47 (16%) had stage II, III, and IV, respectively. Among patients with known axillary nodal status (242 patients), only 37% were node-negative whilst 32% and 31% had 1-3, and > or = 4 positive nodes, respectively. Adjuvant chemotherapy and tamoxifen were commonly offered; nonetheless, other adjuvant modalities were rarely utilised. The median follow-up +/- SD of all patients was 62.3 +/- 8.9 months: 152 patients (52%) were alive with no evidence of disease, 25 (9%) were alive with evidence of disease, and 115 (39%) were dead from breast cancer or its related complications. The median survival of the entire group was not obtained, but the 10-year projected survival was 55%. For stage I and II patients, 118 (76%) were alive with a projected 10-year actuarial survival of 64%. On the other hand, only 51 (57%) of patients with stage III disease were alive with a median survival of 41.5 months (95% Confidence interval (CI), 18.9 to 51.3). Patients with stage IV disease demonstrated a poor outcome with a median survival of 23.5 (95%, CI 12.2 to 31.4). Multivariate analyses were performed to explore the influence of independent variables on overall survival (OS) for patients with non-metastatic disease. Besides the expected adverse effect of disease progression, the favourable influence of adjuvant chemotherapy and tamoxifen prevailed. The amount of benefit gained from tamoxifen, however, was small. Similar analyses were undertaken to determine the influence of independent variables on progression free survival (PFS). These analyses ascertained the adverse effects of advanced stage and the favourable impact of adjuvant chemotherapy. Breast cancer in the KSA has features that are distinctive from those of industrialised countries. Survival data, however, were comparable. The favourable influence of adjuvant chemotherapy was evident on both OS and PFS. Adjuvant tamoxifen, however, had little effect. Due to its infrequent use, the role of other adjuvant modalities could not be asserted. PMID- 9951688 TI - Establishment of a monoclonal antibody to human myeloma cell: relation to chemotherapy and extramedullar infiltration. AB - Resistance of myeloma cells to melphalan (L-PAM) is a serious problem. To investigate mechanisms of drug resistance, we generated a monoclonal antibody, clone O3, to melphalan-resistant myeloma cells, KHM-11R. Western blot analysis showed that molecular weight of O3 antigen was approximately 90 kDa. Expression of O3 antigen was approximately two times higher in KHM-11R than in parental melphalan sensitive cell line, KHM-11. O3 was preferentially expressed in plasma cell, B-cell, and monocytic cell lines, but not in T-cell lines. Analysis of bone marrow samples from myeloma patients revealed that 13 of 23 samples expressed O3 antigen at various levels, and that O3 antigen expression in patients correlate with preceding chemotherapy, advanced clinical stage and extramedullar invasion of myeloma cells. Furthermore, patients expressing O3 antigen at the time of diagnosis tended to have poor prognosis. The investigation of O3 antigen in myeloma cells will be useful to reveal the pathophysiology of extramedullar invasion and the mechanism of cell killing by melphalan. PMID- 9951689 TI - Complete sequence of p53 gene in 20 patients with lung cancer: comparison with chemosensitivity and immunohistochemistry. AB - In this study the entire p53 complementary DNA has been sequenced in 20 non-small cell lung carcinomas (NSCLC) and the results correlated with chemosensitivity, immunohistochemistry and clinical data. Ten patients had mutations in p53, 8 missense mutations and 2 nonsense mutations. The method discovered two mutations never described previously and two other mutations that have never been described before in connection with NSCLC tumours. Chemosensitivity data, according to a short-term assay (FMCA), indicated that tumours with p53 mutation were more resistant to cisplatin and cyclophosphamide. Immunohistochemical studied demonstrated a 70% concordance between over-expression of p53 protein and mutation in p53. No conclusions or trends could be drawn from the immunohistochemical studies of Bcl-2 and Bax. PMID- 9951691 TI - Outbreak of nosocomial Acinetobacter baumannii bacteremia in a high risk ward. AB - Acinetobacter baumannii is emerging as a major cause of nosocomial infections particularly in high risk patients. Being resistant to adverse environmental conditions, it can stay for prolonged periods in the hospital environment. We report an outbreak in the medical oncology ward where nine patients suspected of bacteraemia were blood culture positive for A. baumannii from the two samples each, one collected through the i.v. cannula and another through the peripheral veneous puncture. The bacteria was also isolated from the environmental sources from the various samples collected. The biotype, antibiogram, cellular protein profiles on SDS-PAGE and the restriction enzyme analysis patterns of the patient isolates and the environmental isolates were similar. This points to the environment as a source of infection. With reinforcement of proper barrier nursing and use of disposable heparine ampoules it was possible to control the outbreak. PMID- 9951690 TI - Photoprotective effects of some quinoxaline 1,4-dioxides in hairless mice. AB - 2-benzoyl-3-phenylquinoxaline 1,4-dioxide (BPQ) and other substituted quinoxaline 1,4-dioxides (QdO) were tested for their ability to inhibit the stimulations of ornithine decarboxylase (ODC) enzyme activity and DNA synthesis, two biochemical markers linked to skin tumour promotion by ultraviolet B (UVB) radiation. Topical application of BPQ on the dorsal skin of hairless mice was found to inhibit in a dose-dependent manner UVB-induced ODC activity and DNA synthesis. When applied 20 min before UVB radiation, a dose of 17 mg BPQ applied in 0.4 ml of vehicle inhibited UVB-induced ODC activity and DNA synthesis by 95% and 85%, respectively. This inhibitory effect is dependent on the time of administration of BPQ relative to UVB radiation, with a generally greater inhibition observed when this compound is applied before rather than after UVB treatment. The inhibitory abilities of the other QdO on the ODC and DNA responses induced by UVB radiation greatly varied and appear to be dependent on the structure of the compounds and their metabolic activation in the skin following irradiation. The remarkable effectiveness of BPQ against the ODC and DNA markers of UVB promotion is also observed following multiple applications of this agent. These results suggest that QdO, in particular BPQ and certain derivatives of it, may be useful in protecting the skin against UVB-induced skin damage. PMID- 9951692 TI - Platelet dysfunction as the presenting feature of atypical myelodysplastic syndrome with monosomy 7, normal blood counts and no bleeding tendency. AB - A 71-year-old male patient with atypical myelodysplastic syndrome showing monosomy 7 is described. He presented with severe foot pains, trophic skin and nail changes, loss of distal pulses, all compatible with peripheral arterial occlusive disease. He had completely normal blood counts and no bleeding tendency. Prolonged bleeding time was disclosed by chance, during routine haemostatic studies. An acquired platelet dysfunction was considered, with prolonged bleeding time and large platelets that failed to aggregate in response to arachidonic acid and that had impaired response to collagen and adrenaline. The bone marrow was hypercellular, with numerous dysplastic megakaryocytes and two other slightly dysplastic myeloid lines. Cytogenetic analyses of the bone marrow cells showed a mosaic karyotype: 46,XY/45,XY,-7. On angiography, bilateral thrombosis of the iliac, superficial femoral and popliteal was disclosed. The patient was prepared with platelet transfusions. Arterial thrombectomy and amputation of the left calf were performed. Ten months later, his blood counts showed mild pancytopenia. He died at home. The authors discuss some clinical and pathogenetical aspects of such presentations of myelodysplastic syndromes. PMID- 9951693 TI - Combined radiation and chemotherapy in posttransplant lymphoproliferative disorder. AB - The optimal treatment for posttransplant lymphoproliferative disorder which has progressed despite a reduction in immunosuppression has not been defined. We report on two patients with stage I posttransplant lymphoproliferative disorder who developed progressive disease despite a reduction in the level of immunosuppression. Both patients were treated with combined short course CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy followed by involved-field radiation therapy. In both patients, a rapid response was obtained followed by complete remission. Combined modality therapy can be utilized successfully in progressive limited stage posttransplant lymphoproliferative disorder. PMID- 9951695 TI - Non-secretory solitary plasmacytoma of the spleen. AB - A case of primary nonsecretory plasmacytoma of the spleen is reported. On laparotomy and splenectomy a 920 g spleen was removed, measuring 16 x 14 x 6 cm. The cut surface of the entire spleen showed that the tumour occupied most of the splenic tissue. A bone marrow aspirate and trephine, skeletal survey showed no signs of myeloma. Biopsy of the liver and regional lymph nodes was normal. Immunocytochemistry of the splenic tumour showed positivity for pan-B and plasma cell markers. After splenectomy the patient was treated with chemotherapy according to protocol VBCMP (M2). PMID- 9951694 TI - Metastasis of bronchogenic carcinoma to the thumb. AB - Bone metastasis in the hand is rare. The etiology is quite different from that of metastasis to other bones; bronchogenic carcinoma is by far the most frequent case. Distal phalanges are mainly involved with irregular osteolysis and cortical destruction. Differential diagnosis of phalangeal metastasis includes osteomyelitis, rheumatoid arthritis and gout. The prognosis is always that of metastatic bronchial cancer with an average survival of three months. Treatment may involve distal digital amputation or antalgic radiotherapy. A case of bronchogenic carcinoma with metastasis to the thumb is presented. The metastasis was located in the distal phalanx of the left thumb. The primary tumor was located in the lung. Treatment consisted of amputation. The overall survival was five months. PMID- 9951696 TI - Systemic lupus erythematosus associated with primary large cell carcinoma of the lung. AB - The association between systemic lupus erythematosus (SLE) and malignancy has been controversial in the literature. We report a case of lung cancer in a 50 year-old woman with a 4-year history of SLE. She underwent surgery at a pathological stage of T2N2M0, but she eventually died of rapid recurrence of the cancer in the abdomen resulting in massive haemorrhage from the inferior vena cava (IVC). Immunological disorders related to SLE are thought to contribute to rapid progression of the malignancy. PMID- 9951697 TI - Metastatic small cell lung cancer causing biliary obstruction. AB - We report a case with metastatic small cell lung cancer which first manifested with biliary obstruction due to metastasis. Prognosis of patients presenting with jaundice due to hepatic parenchyma involvement is thought to be poor. However, the patient was successfully treated with percutaneous transhepatic biliary drainage and combination chemotherapy with reduced dosage. We believe this to be the first such case report, despite the frequency of metastasis to the liver from small cell lung cancer. PMID- 9951698 TI - High-level expression of murine terminal deoxynucleotidyl transferase in Escherichia coli grown at low temperature and overexpressing argU tRNA. AB - Terminal deoxynucleotidyl transferase (TdT) is a highly conserved vertebrate enzyme that possesses the unique ability to catalyze the random addition of deoxynucleoside 5'-triphosphates onto the 3'-hydroxyl group of a single-stranded DNA. It plays an important role in the generation of immunoglobin and T-cell receptor diversity. TdT is usually obtained from animal thymus gland or produced in a baculovirus system, but both procedures are rather tedious, and proteolysis occurs during purification. Attempts to overexpress TdT in bacteria have been unsuccessful or have yielded an enzyme with a lower specific activity. A dearth of TdT has thus hampered detailed structural and functional studies. In the present study, we report that by lowering growth temperature and overexpressing a rare arginyl tRNA, it is possible to boost the production in Escherichia coli of murine TdT with minimal proteolysis and high specific activity. PMID- 9951699 TI - Energy dissipation as a key factor for electroporation of protoplasts. AB - Energy dissipation (epsilon) during electroporation was theoretically determined to be epsilon = 0.5CV02 for the various combinations of capacitance (C) and initial voltage (V0). Experiments on asparagus protoplasts established that electroporation efficiency (EE) and survival rate were directly proportional to energy dissipation during electroporation. A positive linear relationship exists between energy dissipation per unit volume and EE, whereas energy dissipation per unit volume and survival rate of protoplasts are related in a negative linear manner. At the same energy level, longer time constants were more effective at increasing EE. This suggests that energy dissipation approximating rectangular waveforms is more important than that dissipated as sharply decaying exponential waveforms. With energy as the key parameter, the optimization of electrical parameters for efficient electroporation is greatly simplified, is not machine dependent, and generally applies to all species. PMID- 9951700 TI - Cloning and nucleotide sequence of the thermostable beta-galactosidase gene from Pyrococcus woesei in Escherichia coli and some properties of the isolated enzyme. AB - Pyrococcus woesei (DSM 3773) beta-galactosidase gene amplified by polymerase chain reaction was cloned into KpnI and HindIII binding sites of pET-30LIC expression plasmid. The obtained pGal2 (6785 bp) transcription vector was then transferred to Escherichia coli B121 (DE3) cells. High identity (99.9%) of DNA sequences suggests that beta-galactosidases from P. woesei and Pyrococcus furiosus are closely related. This enzyme from E. coli transformant is a unique thermostable protein in the cells and can be successfully separated by thermal precipitation of other bacterial proteins at 85 degrees C. The crude beta galactosidase remaining in the solution comprises about 21% of the total amount of proteins extracted from E. coli cells and has maximal activity at pH 5.4 and temperature of 93 degrees C. Isolated enzyme is active at temperatures up to 110 degrees C and the activity loss after 4 h of incubation at 85 and 93 degrees C did not exceed 11 and 15% of the initial value respectively. PMID- 9951701 TI - Gene digging. A method for obtaining species-specific sequence based on conserved segments of nucleotides in open reading frames. AB - A method termed "gene digging" has been developed based on our observation of stretches of highly conserved nucleotide sequence in the coding region of many genes across related species. Rabbit-specific nucleotide sequences corresponding to desired coding segments of 14 different genes were obtained with primers that were designed based on conserved nucleotide stretches. Our success in gene digging could be attributable to the method's inherent ability to reduce the degeneracy of primers by more than two orders of magnitude (sometimes by more than three orders of magnitude) compared to primers designed from conserved amino acids. Our results not only demonstrate the value of the method, but also hint at a thus far unknown functional significance of conserved nucleotide stretches in the coding region of various genes. In our hands the method worked 14 out of 14 times indicating generality of the concept. PMID- 9951702 TI - Two-step cycle sequencing reduces premature terminations when using primers with high annealing temperatures. AB - Direct cycle sequencing of double-stranded polymerase chain reaction (PCR) products using thermostable polymerases produces fragments that are shorter than expected when the enzyme prematurely detaches as it approaches the 5'-end of the DNA template. These premature terminations result in a substantially reduced reading length of the DNA sequence. Since some DNA templates spontaneously fold and form stable secondary structures at temperatures that are typically used for primer annealing, one factor that may cause premature terminations to occur is the formation of secondary structures in the template during the annealing step of the cycle sequencing reaction. We describe a simple and effective method for reducing premature terminations in DNA sequences. We demonstrate that maintaining the annealing temperature of the cycle sequencing reaction above a critical temperature reduces premature terminations in DNA sequences that regularly contain premature terminations when the temperature of the annealing step is 60 degrees C. In the method described, annealing and extension of the primer along the template take place at the same temperature (72 degrees C). This procedure for reducing premature terminations can be applied when sequencing with primers that are relatively long (at least 27 mer) and have high optimal annealing temperatures. PMID- 9951704 TI - ELISA-based assay for scatchard analysis of ligand-receptor interactions. AB - A simple, nonradioactive method is presented that can be used for performing large numbers of binding assays of cell membrane receptors with their ligands. The method adopts the simple membrane preparation and biotin-based quantitation methods of the semi-intact cell endocytosis assays. After binding of the biotinylated ligand to its receptors on the semi-intact cell membranes, a rapid centrifugation step separates the membranes from unbound ligand. Bound ligand is subsequently released by detergent, captured by a specific antibody coated on teh surface of microwells, and quantitated with peroxidase-conjugated streptavidin in a colorimetric assay. Using this assay, Scatchard analysis was performed on the data for the specific binding of iron-loaded transferrin to its receptors on mouse fibroblasts and yielded Kd values similar to those obtained with other published methods. The assay is sensitive, rapid, and also convenient, because aliquots of semi-intact cells can be stored frozen. The perforated plasma membrane of the cells offers the additional possibility of screening factors that interact with the cytoplasmic domain of the receptors for their possible effects on the parameters of the extracellular ligand-receptor interaction. PMID- 9951705 TI - Picolinyl esters for the structural determination of fatty acids by GC/MS. AB - The position of unsaturation, chain branching, and other structural features of fatty acids are not often apparent from the mass spectra of common derivatives such as methyl esters because of factors such as charge location at the carboxy termiunus and migration of double bonds. The spectra of picolinyl esters, on the other hand, contain fragment ions that provide this information. The esters are synthesized by reaction of the acids with thionyl chloride to form the acid chloride that is reacted with 3-pyridylcarbinol to give the ester. Under electron impact conditions in the mass spectrometer, an electron is removed from the nitrogen of the pyridine ring and a hydrogen atom is abstracted from the alkyl chain to this electron-deficient site. This process produces a radical site in the chain that initiates chain cleavage. Hydorgen atoms can be removed from any position of the chain with varying probability, depending on the chain structure. Thus, diagnostic ions are produced from each type of fatty acid whose masses and relative abundances reflect the structure of the alkyl chain and any substituents. Patterns of fragmentation for straight-chain, branched-chain, unsaturated and cyclic fatty acids are described together with those containing hydroxy-, epoxy-, keto-, and ether groups. PMID- 9951703 TI - Origins and development of peptide antibiotic research. From extracts to abstracts to contracts. AB - That cationic proteins might be factors on the antimicrobial defenses of mammalian hosts and are apparently associated with the cytoplasmic granules of phagocytic leukocytes first became evident on the late nineteenth century. It remained, however, for development of sophisticated microanalytic techniques in microbiology, cell biology and protein biochemistry to place these hypotheses in the realm of established theory. This article is a brief summary of significant steps in the development of this theory. It also attempts to outline the firmly established scope and significance of these developments both for the theory of immunity to infection in the different phyla and for the now global quest for new antibiotics. PMID- 9951706 TI - Differential display. A general protocol. AB - Characterization of regulated gene expression in eukaryotic cells is essential for studying cell growth and differentiation as well as for understanding the molecular mechanisms of diseases. Differential display was developed for such comparative studies by allowing a systematic and nonbiased screening for molecular differences at the level of mRNA expression between or among different cells or tissues. The essence of the method is to amplify messenger RNA 3' termini using a pair of anchored oligo-dT primer and a short primer with an arbitrary sequence. The amplified cDNAs labeled with radioisotope are then distributed on a denaturing polyacrylamide gel and visualized by autoradiography. Side-by-side comparison of mRNA species from two or more related samples allows identification of both up- and downregulation genes of interest. Some of the most recent improvements have been incorporated into this general protocol for differential display. PMID- 9951707 TI - Efficient identification of point mutations by automated DNA sequencing of artificial heterozygote samples. AB - DNA sequencing templates of individual point mutants of the lacI target gene were amplified by polymerase chain reaction (PCR). By mixing the PCR fragments from two individual mutants in a defined ratio, samples of artificial heterozygous composition were prepared. These samples were then submitted to automated DNA sequencing. The simultaneous, visual comparison of the mixed mutant traces using a graphics program efficiently revealed all heterozygous positions. Based on the individual intensities of the heterozygous base signals the identified point mutations could be assigned to the corresponding mutants. This efficient approach doubles the sample throughput for both the sequencing reactions and the gel electrophoresis using an automated DNA sequencing system. PMID- 9951708 TI - pUCPCR1. A vector for direct cloning of PCR products in a double Xcm1 restriction site offering compatible single 3'-overhanging T residues. AB - The multiple cloning site of pUC19 was replaced by a multiple cloning site possessing a double Xcm1 restriction site. Digestion with XcmI gives a linear vector with a single 3'-overhanging T-residue at both ends. This provides the easiest way of creating a vector in which PCR fragments produced by Taq polymerase can be directly cloned without further modifications. PMID- 9951709 TI - Toward a model of neuropsychological activity. AB - The main purpose of this research was to establish the intercorrelations existing among different psychological and neuropsychological test scores in a normal and homogeneous population. A second purpose was to attempt further step in the component analysis of cognitive activity measured by means of neuropsychological tests. A comprehensive neuropsychological test battery was assembled and individually administered to a 300-subject sample, aged 17-25 year-old. All of them were right-handed male university students. The battery included some basic neuropsychological tests directed to assess language, calculation abilities, spatial cognition, praxic abilities, memory, perceptual abilities, and executive functions. In addition, the Wechsler Adult Intelligence Scale was administered. Forty-one different scores were calculated. Correlations among the different test scores were analyzed. It was found that some of the tests presented a quite complex intecorrelation system, whereas other tests presented few or no significant correlations. Mathematical ability tests and orthography knowledge represented the best predictors of Full Scale IQ. A factor analysis with varimax rotation disclosed five factors (verbal, visuoperceptual, executive function, fine movements, and memory) accounting for 63.6% of the total variance. Implications of these results for a neuropsychological model about brain organization of cognition were analyzed. PMID- 9951710 TI - Methodological considerations in the neuropsychological study of central nervous system underarousal with a specific emphasis on coma. AB - Several obstacles exist that impede the scientific study of pathological underarousal (stupor and coma). For instance, there is a lack of a clear, rational, standardized taxonomy with which to describe the phenomenon. Moreover, there is considerable confusion of the construct of arousal with other neurobehavioral constructs. The field also suffers from a general lack of acceptably reliable and valid instruments, especially measures of long-term outcome. Additionally, current treatments for chronic pathological underarousal are frequently presumptive and applied haphazardly, and thus do little to elucidate the process of recovery. It is suggested that biomedical and neuropsychological approaches to the study and treatment of pathological underarousal are complementary and that it is useful to view pathological underarousal as a behavioral, as well as a medical, phenomenon. PMID- 9951711 TI - Neuropsychological evaluation of everyday memory. AB - The evaluation of everyday memory (EM) was reviewed and reconceptualized. EM has established new objectives of study and the development of new methods to reach these objectives. At the basic level, this approach has already produced important discoveries and the development of new principles about memory and functioning. At the clinical level, this new area of investigation has resulted in evaluating deficits of EM, which is defined as what daily life functions remain impaired after a deficit pathology has occurred. A type of evaluation has evolved that is oriented toward treatment and extremely useful in designing rehabilitation programs for individuals with alterations in memory. PMID- 9951712 TI - A mathematical analysis of the spread of HIV/AIDS in Japan. AB - The spread of HIV/AIDS in Japan was analysed using a mathematical model incorporating pair formations between adults and sexual contacts with commercial sex workers. The parameters involved in the model were carefully specified as realistically as possible to the actual situation in Japan. Plausible ranges were assigned to those parameters for which values are not known precisely. The model was used to simulate the effect of HIV infected commercial sex workers introduced into a population without HIV. It was shown that the model could generate different scenarios, an explosive infection or a temporal spread, according to different settings of the parameters. Then the condition for occasional introduction of HIV infected commercial sex workers to be able to cause an explosive spread of HIV infection was analysed. This condition was summarized in terms of the critical transmission probability so that we could easily evaluate the degree of the risk. For some unclear parameters, sensitivity to the critical transmission probability was calculated. We also calculated a plausible range of the critical transmission probability using the Latin hypercube sampling method where the parameters were distributed on the plausible ranges. According to the analyses of the model it is concluded that the actual situation of HIV spread in Japan should lie very near the critical point that determines whether the explosive HIV spread actually takes place. This also suggests that effective action taken immediately could be useful to prevent explosive HIV infection in Japan. PMID- 9951713 TI - Patient-ventilator interaction: a general model for nonpassive mechanical ventilation. AB - A general mathematical model for the dynamic behaviour of a single-compartment respiratory system in response to an arbitrary applied inspiratory airway pressure and arbitrary respiratory muscle activity is investigated. The model is used to compute explicit expressions for ventilation and pressure variables of clinical interest for clinician-selected and impedance-determined inputs. The outcome variables include tidal volume, end-expiratory pressure, minute ventilation, mean alveolar pressure, average pleural pressure, as well as the work performed by the ventilator and the respiratory muscles. It is also demonstrated that under suitable conditions, there is a flow reversal that can occur during inspiration. PMID- 9951715 TI - Stability analysis of the FitzHugh-Nagumo differential equations driven by impulses: applied to the electrical firing of magnocellular neurons. AB - A stability analysis is carried out for a mathematical model which describes the electrical firing of a single vasopressin neuron. The model used in a FitzHugh Nagumo-type system which is driven by impulses. The analysis is based on recent developments in the stability theory of impulsive differential equations. Conditions are derived under which the system of differential equations is stable at two of its equilibrium points. Biologically this bistability represents the cell alternating between periods of electrical activity and silence. The conditions for stability are specified in terms of the amplitude and frequency of the impulses perturbing the system. Both stochastic and deterministic impulses are considered. PMID- 9951714 TI - Surface aggregation patterns of LDL receptors near coated pits. I. The radially convective diffusion and generalized insertion mechanism. AB - In this paper we formulate a mathematical model for the receptor mediated endocytotic cycle under the influence of diffusion, radial convection, and generalized receptor reinsertion. The steady state radial concentration function of unbound receptors admits an explicit representation. This can be expressed as a functional of the insertion rate, the diffusion coefficient, and the flow strength. Using the referred functional we study the influence of the aforementioned mechanisms on the surface aggregation pattern of low density lipoprotein (LDL) receptors near coated pits. We perform that analysis on both a theoretical level and by means of simulated receptor aggregation patterns obtained by computer graphics techniques. We conclude that radially convective diffusion in combination with suitable characterizations of the insertion mode are consistent with reported cell surface aggregation patterns. PMID- 9951716 TI - Scaling of the limb long bones to body mass in terrestrial mammals. AB - Long-bone scaling has been analyzed in a large number of terrestrial mammals for which body masses were known. Earlier proposals that geometric or elastic similarity are suitable as explanations for long-bone scaling across a large size range are not supported. Differential scaling is present, and large mammals on average scale with lower regression slopes than small mammals. Large mammals tend to reduce bending stress during locomotion by having shorter limb bones than predicted rather than by having very thick diaphyses, as is usually assumed. The choice of regression model used to describe data samples in analyses of scaling becomes increasingly important as correlation coefficients decrease, and theoretical models supported by one analysis may not be supported when applying another statistical model to the same data. Differences in limb posture and locomotor performance have profound influence on the amount of stress set up in the appendicular bones during rigorous physical activity and make it unlikely that scaling of long bones across a large size range of terrestrial mammals can be satisfactorily explained by any one power function. PMID- 9951717 TI - Growth of tobacco in short-day conditions leads to high starch, low sugars, altered diurnal changes in the Nia transcript and low nitrate reductase activity, and inhibition of amino acid synthesis. AB - Diurnal changes in carbohydrates and nitrate reductase (NR) activity were compared in tobacco (Nicotiana tabacum. L.cv. Gatersleben) plants growing in a long (18 h light/6 h dark) and a short (6 h light/18 h dark) day growth regime, or after short-term changes in the light regime. In long-day-grown plants, source leaves contained high levels of sugars throughout the light and dark periods. In short-day-grown plants, levels of sucrose and reducing sugars were very low at the end of the night and, although they rose during the light period, remained much lower than in long days and declined to very low levels again by the middle of the night. Starch accumulated more rapidly in short-day-than long-day-grown plants. Starch was completely remobilised during the night in short days, but not in long days. A single short day/long night cycle sufficed to stimulate starch accumulation during the following light period. In long-day-grown plants, the Nia transcript level was high at the end of the night, decreased during the day, and recovered gradually during the night. In short-day-grown plants, the Nia transcript level was relatively low at the end of the night, decreased to very low levels at the end of the light period, increased to a marked maximum in the middle of the night, and decreased during the last 5 h of the dark period. In long-day-grown plants, NR activity in source leaves rose by 2- to 3-fold in the first part of the light period and decreased in the second part of the light period. In short-day-grown plants, NR activity was low at the end of the night, and only increased slightly after illumination. Dark inactivation of source-leaf NR was partially reversed in long-day-grown plants, but not in short day-grown plants. In both growth regimes, mutants with one instead of four functional copies of the Nia gene had a 60% reduction in maximum NR activity in the source leaves, compared to wild-type plants. The diurnal changes in NR activity were almost completely suppressed in the mutants in long days, whereas the mutants showed similar or slightly larger diurnal changes than wild-type plants in short days. When short-day-grown plants were transferred to long-day conditions for 3 d, NR activity and the diurnal changes in NR activity resembled those in long-day grown plants. Phloem export from source leaves of short-day-grown plants was partially inhibited by applying a cold-girdle for one light and dark cycle. The resulting increase in leaf sugar was accompanied by an marked increase in the Nia transcript level and a 2-fold increase in NR activity at the end of the dark period. When wild-type plants were subjected to a single short day/long night cycle of increasing severity, NR activity in source leaves at the end of the night decreased when the endogenous sugars declined below about 3 mumol hexose (g FW)-1. In sink leaves in short-day conditions, sugars were higher and the light induced rise in NR activity was much larger than in source leaves on the same plants. The source leaves of wild-type plants in short-day conditions contained very high levels of nitrate, very low levels of glutamine, low levels of total amino acids, and lower protein and chlorophyll, compared to long-day-grown plants. Plants grown in short days had relatively high levels of glutamate and aspartate, and extremely low levels of most of the minor amino acids in their source leaves at the end of the night. Illumination led to a decrease in glutamate and an increase in the minor amino acids. A single short day/long night cycle led to an increase in glutamate, and a large decrease in the minor acids at the end of the dark period, and reillumination led to a decrease in glutamate and an increase in the minor amino acids. It is proposed that sugar-mediated control of Nia expression and NR activity overrides regulation by nitrogenous compounds when sugars are in short supply, resulting in a severe inhibition of nitrate assimilation. It is also proposed that su PMID- 9951718 TI - A 56-kDa protein is a novel granule-bound starch synthase existing in the pericarps, aleurone layers, and embryos of immature seed in diploid wheat (Triticum monococcum L.). AB - A novel 56-kDa granule-bound starch synthase (GBSS; NDPglucose-starch glucosyltransferase, EC 2.4.1.21) responsible for amylose synthesis was found in the pericarps, aleurone layers and embryos of immature diploid wheat (Triticum monococcum L.). The GBSS and other proteins bound to starch granules of various tissues of immature normal and waxy diploid wheat seeds were separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and their activities were examined. In the waxy mutant, the waxy protein (59.5 kDa, GBSSI) was absent, but amylose and GBSS activity were evident in all tissues except the endosperm. Of the proteins bound to starch granules, only the 56-kDa protein was associated with the presence of amylose and GBSS activities in the pericarps, aleurone layers and embryos. Mutations at the waxy locus did not affect the 56 kDa protein in these tissues. Changes in the amount of 56-kDa protein during the course of seed development, and the distribution of the 56-kDa protein in each tissue of immature seeds were quite different from those of the waxy protein. On the other hand, the N-terminal amino acid sequence of the 56-kDa protein had a 40 50% similarity to GBSSI of some other plant species and was antigenically related to the waxy protein. These results strongly suggest that the 56-kDa protein in diploid wheat is a GBSSI class enzyme and, hence, an isoform of the waxy protein. The waxy protein and 56-kDa protein, however, are expressed in different seed tissues and at different stages of seed development. PMID- 9951719 TI - Cellular localization of a plant protein PSAM 1 in arbuscular mycorrhizas of Pisum sativum. AB - Psam 1 is a single-copy gene which is activated during early plant-fungal interaction in wild-type pea inoculated with Glomus mosseae and which codes for PSAM 1, a putative protein of 108 amino acids. A synthetic peptide was designed of 108 amino acids. A synthetic peptide was designed in an antigenic region of this protein to produce a polyclonal antibody against PSAM 1 and to investigate its cellular localization. Western blot analysis revealed that a polypeptide of about 14.5 kDa accumulated more in mycorrhizal than non-mycorrhizal pea roots. The PSAM 1 antigen was immunolocated in planta in arbuscule-containing cells of mycorrhizal roots and especially in the cytoplasm surrounding young arbuscules in cortical cells, which suggests that its accumulation is somehow related to the symbiotic state of these cells. PMID- 9951720 TI - The expression of the salt-responsive gene salT from rice is regulated by hormonal and developmental cues. AB - The expression pattern of the salT gene was analyzed in different cell types and organs of rice (Oryza sativa L.) in response to saline and hormonal treatments to obtain detailed information on the physiological cues controlling gene expression. Gel blot analysis of RNA and in-situ hybridization performed on seedlings grown for 10 ds in the presence of 1% NaCl revealed that salT was expressed mainly in the younger tissues of the plant. In contrast, 6-week-old plants exhibited maximal salT mRNA accumulation in sheaths of older leaves. In addition, salT was normally expressed in rapidly dividing suspension-cultured cells, but not in quiescent ones. Altogether, these results may indicate that salT expression in each region of the plant is dependent on the metabolic activity of the cells as well as on whether or not they are stressed. The effects of two growth regulators, abscisic acid (ABA) and gibberellic acid, were investigated in combination with the effects of NaCl. Gibberellic acid had a synergistic effect on the induction of the salT gene when combined with 0.5% NaCl, but did not induce salT on its own. At 10 microM, ABA induced salT both in the absence of NaCl and in its presence. Whereas 1 microM ABA acted additively with NaCl to induce gene expression, 5 microM ABA with NaCl was only as effective as NaCl alone. This may indicate that the two stimuli act independently and possibly through antagonistic signal transduction pathways. PMID- 9951721 TI - Isolation and molecular characterization of a new vegetative MADS-box gene from Solanum tuberosum L. AB - A cDNA clone, STMADS11, encoding a new MADS-box protein was isolated from Solanum tuberosum L. (potato). Expression of STMADS11 was found in all vegetative organs of the plant, but not in floral tissues. The expression was also detected in all developmental stages, from tuber sprouts to mature plants, reaching a maximum in well-developed organs. However, the level of STMADS11 mRNA was low in tissues such as resting tuber or sprouts developed in the cold, where the metabolic activity is reduced. "In situ" hybridizations performed on leaf and stem sections showed that the STMADS11 transcript is mainly associated with vascular bundles. Cladistic analysis arising from amino acid sequence comparison revealed that STMADS11 shows the highest similarity to STMADS16, another vegetative MADS-box gene from potato, and to the previously reported "orphan" genes AGL15 and AGL17 from Arabidopsis thaliana. Possible implications of these data in relation to STMADS11 function are discussed. PMID- 9951726 TI - Expression of the Arabidopsis thaliana invertase gene family. AB - Cell-wall and vacuolar invertases (beta-D-fructofuranosidase, EC 3.2.1.26) from Arabidopsis thaliana (L.) Heynh. are encoded by at least four genes, namely At beta fruct1, At beta fruct2, At beta fruct3 and At beta fruct4. Different A. thaliana organs from four developmental stages and under different environmental conditions were analyzed for invertase gene expression. Our results clearly show that both the cell-wall and vacuolar invertase genes are expressed in a development and organ-specific manner. No transcripts of the cell-wall invertase gene At beta fruct1 were found in the cotyledons; however, relatively high levels were detected in the leaves of mature plants. The expression of the second cell wall gene At beta fruct2 was found to be flower-specific, conversely no expression of At beta fruct1 was detected in flowers. The vacuolar gene At beta fruct3 shows a distinctly different regulation of expression from At beta fruct1. Northern and reverse transcriptase-polymerase chain reaction analyses revealed the presence of transcripts in the cotyledons and only low levels in leaves, roots and flower buds. The second vacuolar invertase gene, At beta fruct4, was found to be expressed in leaves of very young plants, but no transcripts were detected in the leaves of mature flowering plants. In order to investigate the respective roles of invertases and sucrose synthase, a comparative analysis of the expression of these genes was carried out. The present study shows that cell wall and vacuolar invertase genes are differentially regulated by environmental factors. PMID- 9951728 TI - Plant NADP-dependent isocitrate dehydrogenases are predominantly localized in the cytosol. AB - The isoenzyme patterns of NADP-isocitrate dehydrogenase (NADP-IDH; EC 1.1.1.42) have been investigated in 15 species of higher plants using dietylaminoethyl ion exchange chromatography and immunological techniques. The obtained results unambiguously demonstrate that the cytosolic enzyme is the predominant form in leaf extracts of all the surveyed plant species. The chloroplastic isoenzyme, previously reported in pea (Pisum sativum L.) leaves (R.D. Chen et al., 1989, Planta 178; 157-163), is a minor form in ferns and dicotyledonous angiosperms and is undetectable in gymnosperms and monocotyledonous angiosperms. Comparison of immunological relatedness suggests that the proteins of cytosolic isoenzymes have been highly conserved in the course of plant evolution. The data support the previously proposed idea that the cytosol is the major site for alpha ketoglutarate production to be used for nitrogen assimilation. PMID- 9951729 TI - Clp protease complexes and their diversity in chloroplasts. AB - The Clp proteases represent a large, ancient ATP-dependent protease family which in higher plants is known to be located in chloroplasts. The soluble, presumably multisubunit, enzyme of the organelle stroma is of dual genetic origin. It consists of a nuclear-encoded, regulatory subunit ClpC, which is an ATPase, and a plastid-encoded proteolytic subunit ClpP, which is a serine protease. An additional, nuclear-encoded proteolytic subunit resembling ClpP has been recently reported from tomato (Schaller and Ryan, 1995 plant gene Register 95-00). We demonstrate that in both tomato Lycopersicon esculentum Mill. and Arabidopsis thaliana, (L.) Heynh. the nuclear-encoded ClpP (nClpP) is made as a precursor molecule that can be imported into isolated intact chloroplasts of spinach (Spinacia oleracea L.) and processed in two or three steps, respectively, to the size of the authentic protein. Furthermore, both gel electrophoresis under non denaturing conditions and size-exclusion chromatography verified that the three proteins can form distinct heteromeric supramolecular complexes of approximately 860, 1380 and 1700 kDa (probably also of 600 kDa) molecular mass. The size ranges of the former two are reminiscent of those of Clp complexes described from Escherichia coli. In addition, various complexes between 160 and 560 kDa are detectable with the individual components. Both the processing "intermediates" and the mature nClpP are found in assembled form. PMID- 9951730 TI - The expression of a symbiosis-regulated gene in eucalypt roots is regulated by auxins and hypaphorine, the tryptophan betaine of the ectomycorrhizal basidiomycete Pisolithus tinctorius. AB - A full-length cDNA coding for a symbiosis-regulated transcript, EgHypar, was isolated by differential screening from a Eucalyptus globulus bicostata- Pisolithus tinctorius ectomycorrhiza. The sequence of this clone revealed a protein with an estimated molecular mass of 25.5 kDa that exhibited a high degree of homology (66%) with plant auxin-induced glutathione-S-transferases. Expression of the EgHypar gene in seedlings was confined largely in roots and it is drastically increased by ectomycorrhiza development. The concentration of EgHypar transcripts was similarly up-regulated in roots incubated in media supplemented with P. tinctorius cell-free extracts, indole-3-acetic acid, 2,4 dichlorophenoxyacetic acid or hypaphorine (tryptophan betaine), the major indolic compound secreted by P. tinctorius. The latter fungal alkaloid concomitantly induced a decrease in root hair elongation in eucalypt seedlings. Up-regulation of EgHypar expression by auxins and fungal metabolites suggests that this symbiosis-regulated gene could be involved in the morphological changes taking place in plants roots upon symbiosis development. To our knowledge, these results provide the first molecular evidence that gene expression of the host plant is altered by molecules produced by the ectomycorrhizal mycobiont. PMID- 9951731 TI - A unique reaction in a common pathway: mechanism and function of chorismate synthase in the shikimate pathway. AB - Chorismate synthase, the seventh enzyme in the shikimate pathway, catalyzes the transformation of 5-enolpyruvylshikimate 3-phosphate to chorismate which is the last common precursor in the biosynthesis of numerous aromatic compounds in bacteria, fungi and plants. The enzyme has an absolute requirement for reduced FMN as a cofactor, although the 1,4-anti elimination of phosphate and the C(6proR)-hydrogen does not involve a net redox change. The role of the reduced FMN in catalysis has long been elusive. However, recent detailed kinetic and bioorganic approaches have fundamentally advanced our understanding of the mechanism of action, suggesting an initial electron transfer from tightly bound reduced flavin to the substrate, a process which results in C-O bond cleavage. Studies on chorismate synthases from bacteria, fungi and plants revealed that in these organisms the reduced FMN cofactor is made available in different ways to chorismate synthase: chorismate synthases in fungi--in contrast to those in bacteria and plants--carry a second enzymatic activity which enables them to reduce FMN at the expense of NADPH. Yet, as shown by the analysis of the corresponding genes, all chorismate synthases are derived from a common ancestor. However, several issues revolving around the origin of reduced FMN, as well as the possible regulation of the enzyme activity by means of the availability of reduced FMN, remain poorly understood. This review summarizes recent developments in the biochemical and genetic arena and identifies future aims in this field. PMID- 9951732 TI - The MSG1 and AXR1 genes of Arabidopsis are likely to act independently in growth curvature responses of hypocotyls. AB - Growth-curvature responses of hypocotyls of Arabidopsis thaliana (L.) Heynh. were measured in double mutants between msg1 and axr1, both of which are auxin resistant and defective in hypocotyl growth curvature induced upon unilateral application of auxin. The msg1 axr1 double mutants showed no auxin-induced growth curvature, that is, they exhibited the msg1 phenotype, though the axr1 defects were partial. Hypocotyls of both the msg1 and axr1 mutants were partially defective in second-positive phototropism, whereas the double mutants lost the response completely. When grown on vertically held agar plates, the axr1 mutant showed normal hypocotyl gravitropism and the mutation did not affect the reduced hypocotyl gravitropism of msg1. Hypocotyls of msg1 and axr1 mutants grew upward like wild-type ones when grown along an agar surface, while they grew more randomly when grown without an agar support, suggesting that axr1 hypocotyls are not completely normal in gravitropism. The extent of defects in growth orientation increased in the order: msg1 axr1 double mutants > msg1 > axr1 > wild type. The hypocotyls of these mutants showed auxin resistance in the order: msg1 axr1 > axr1 > msg1 > wild type. The msg1 mutant had epinastic leaves and axr1 had wrinkled leaves; leaves of the msg1 axr1 double mutants were epinastic and wrinkled. These results suggest that MSG1 and AXR1 act independently in separate pathways of the reactions tested in the present study. In contrast, the phenotype of the msg1 aux1 double mutants shows that AUX1 is not significantly involved in these phenomena. PMID- 9951733 TI - Pronounced differences between the native K+ channels and KAT1 and KST1 alpha subunit homomers of guard cells. AB - Stomatal opening is the result of K(+)-salt accumulation in guard cells. Potassium uptake in these motor cells is mediated by voltage-dependent, K(+) selective ion channels. Here we compare the invitro properties of two guard-cell K(+)-channel alpha-subunits from Arabidopsis thaliana (L.) Heynh. (KAT1) and Solanum tuberosum L. (KST1) after heterologous expression with the respective K(+)-transport characteristics in their mother cell. The KAT1 and KST1 subunits when expressed in Xenopus oocytes shared the basic features of the K(+)-uptake channels in the corresponding guard cells, including voltage dependence and single-channel conductance. Besides these similarities, the electrophysiological comparison of K+ channels in the homologous and the heterologous expression systems revealed pronounced differences with respect to modulation and block by extracellular cations. In the presence of 1 mM Cs+, 50% of the guard-cell K(+) uptake channels (GCKClin) in A. thaliana and S. tuberosum, were inhibited upon hyperpolarization to -90 mV. For a similar effect on KAT1 and KST1 in oocytes, voltages as negative as -155 mV were required. In contrast, compared to the K+ channels in vivo the functional alpha-subunit homomers almost lacked a voltage dependent block by extracellular Ca2+. Similar to the block by Cs+ and Ca2+, the acid activation of the alpha-homomers was less pronounced in oocytes. Upon acidification the voltage-dependence shifted by 82 and 90 mV for GCKCLin in A. thaliana and S. tuberosum, respectively, but only by 25 mV for KAT1 and KST1. From the differences in K(+)-channel modulation in vivo and after heterologous expression we conclude that the properties of functional guard-cell K(+)-uptake channels result either from the heterometric assembly of different alpha-subunits or evolve from cell-type specific posttranslational modification. PMID- 9951734 TI - No induction of beta-oxidation in leaves of Arabidopsis that over-produce lauric acid. AB - Leaves from transgenic Brassica napus L. plants engineered to produce lauric acid show increased levels of enzyme activities of the pathways associated with fatty acid catabolism (V.A. Eccleston and J.B. Ohlrogge, 1998, Plant Cell 10: 613-621). In order to determine if the increases in enzyme activity are mirrored by increases in the expression of genes encoding enzymes of beta-oxidation, which is the major pathway of fatty acid catabolism in plants, the medium-chain acyl-acyl carrier protein (ACP) thioesterase MCTE from California bay (Umbellularia california) was over-expressed under the control of the cauliflower mosaic virus 35S promoter in Arabidopsis thaliana (L.) Heynh. Arabidopsis was the most suitable choice for these studies since gene expression could be analyzed in a large number of independent MCTE-expressing lines using already well characterized beta-oxidation genes. Levels of MCTE transcripts in leaves varied widely over the population of plants analyzed. Furthermore, active MCTE was produced as determined by enzymatic analysis of leaf extracts of MCTE-expressing plants. These plants incorporated laurate into triacylglycerol of seeds, but not into lipids of leaves as shown by gaschromatographic analysis of total fatty acid extracts. The expression levels of the beta-oxidation and other genes that are highly expressed during developmental stages involving rapid fatty acid degradation were measured. No significant difference in gene expression was observed among MCTE-expressing plants and transgenic and non-transgenic controls. To eliminate the possibility that post-translational mechanisms are responsible for the observed increases in enzyme activity acyl-CoA oxidase activity was also measured in leaves of MCTE-expressing plants using medium and long chain acyl-CoA substrates. No significant increases in either medium- or long-chain acyl-CoA oxidase activities were detected. We conclude that endogenous beta-oxidation is sufficient to account for the complete degradation of laurate produced in rosette leaves of Arabidopsis expressing MCTE. PMID- 9951735 TI - Overexpression of rice phytochrome A partially complements phytochrome B deficiency in Arabidopsis. AB - The red/far-red reversible phytochromes play a central role in regulating the development of plants in relation to their light environment. Studies on the roles of different members of the phytochrome family have mainly focused on light labile, phytochrome A and light-stable, phytochrome B. Although these two phytochromes often regulate identical responses, they appear to have discrete photosensory functions. Thus, phytochrome A predominantly mediates responses to prolonged far-red light, as well as acting in a non-red/far-red-reversible manner in controlling responses to light pulses. In contrast, phytochrome B mediates responses to prolonged red light and acts photoreversibly under light-pulse conditions. However, it has been reported that rice (Oryza sativa L.) phytochrome A operates in a classical red/far-red reversible fashion following its expression in transgenic tobacco plants. Thus, it was of interest to determine whether transgenic rice phytochrome A could substitute for loss of phytochrome B in phyB mutants of Arabidopsis thaliana (L.) Heynh. We have observed that ectopic expression of rice phytochrome A can correct the reduced sensitivity of phyB hypocotyls to red light and restore their response to end-of-day far-red treatments. The latter is widely regarded as a hallmark of phytochrome B action. However, although transgenic rice phytochrome A can correct other aspects of elongation growth in the phyB mutant it does not restore other responses to end of-day far-red treatments nor does it restore responses to low red:far-red ratio. Furthermore, transgenic rice phytochrome A does not correct the early-flowering phenotype of phyB seedlings. PMID- 9951736 TI - Salt stress in Mesembryanthemum crystallinum L. cell suspensions activates adaptive mechanisms similar to those observed in the whole plant. AB - A salt-tolerant stable cell-suspension culture from the halophyte Mesembryanthemum crystallinum L. has been established from calli generated from leaves of 6-week-old well-watered plants. Optimal cell growth was observed in the presence of 200 mM NaCl, and within 7 d cells were able to concentrate Na+ to levels exceeding those in the growth medium. Accumulation of Na+ was paralled by increases in the compatible solute pinitol and myo-inositol methyl transferase (IMT), a key enzyme in pinitol biosynthesis. Increasing concentrations of NaCl stimulated the activities of tonoplast and plasma-membrane H(+)-ATPases. Immunodetection of the ATPases showed that the increased activity was not due to changes in protein amount that could be attributed to treatment conditions. A specific role for these mechanisms in salt-adaptation is supported by the inability of mannitol-induced water stress to elicit the same responses, and the absence of enzyme activity and protein expression associated with Crassulacean acid metabolism in the cells. Results demonstrate that these M. crystallinum cell suspensions show a halophytic growth response, comparable to that of the whole plant, and thus provide a valuable tool for studying signaling and biochemical pathways involved in salt recognition and response. PMID- 9951737 TI - Changes in the location of polyphenol oxidase in potato (Solanum tuberosum L.) tuber during cell death in response to impact injury: comparison with wound tissue. AB - In order to elucidate the nature of the response of potato to impact injury at the biochemical level, changes in the location of the enzyme responsible for the discoloration, polyphenol oxidase, were determined using immunogold location with an antibody specific for potato tuber polyphenol oxidase. Tissue printing revealed that the enzyme was distributed throughout the tuber. Following impact injury, both tissue printing and quantitative electron microscopy indicated that there was no increase in the level of the enzyme although there was subcellular redistribution of polyphenol oxidase. This redistribution was first apparent at 12 h after impact, as determined by the use of confocal immunolocation, and coincided with loss of membrane integrity. These changes were examined in parallel with a number of stress-related parameters in both impact and wound responses. Wounding was accompanied by active gene expression and protein synthesis, leading to metabolic activity and tissue repair. In contrast, the bruising response was characterised by a limited active response and vital staining methods indicated that after 16 h the tissue undergoes cell death. PMID- 9951739 TI - [The "medicalization" of culture]. PMID- 9951738 TI - Expression analysis of a high-affinity nitrate transporter isolated from Arabidopsis thaliana by differential display. AB - We used the differential display technique on total RNAs from roots of Arabidopsis thaliana (L.) Heynh. plants which had or had not been induced for 2 h by nitrate. One isolated cDNA clone, designated Nrt2:1At, was found to code for a putative high-affinity nitrate transporter. Two genomic sequences homologous to Nrt2:1At were found to be localized on the same fragment of chromosome 1 in the Arabidopsis genome. Expression analyses of both low- and high-affinity nitrate transporter genes, respectively Nrt1:1At (previously named Chl1) and Nrt2:1At, were carried out on plants grown under different nitrogen regimes. In this paper, we show that both genes are induced by very low levels of nitrate (50 microM KNO3). However, stronger induction was observed with Nrt2:1At than with Nrt1:1At. Moreover, these two genes, although both over-expressed in a nitrate-reductase deficient mutant, were differently regulated when N-sufficient wild-type or mutant plants were transferred to an N-free medium. Indeed, the steady-state amounts of Nrt1:1At mRNA declined whereas the amount of Nrt2:1At mRNA increased, probably reflecting the de-repression of the high-affinity transport system during N-starvation. PMID- 9951740 TI - [Regulation of mitochondrial respiration by ADP, O2 and NO]. PMID- 9951741 TI - [Spontaneous neurotransmitter release in neuromuscular synapsis. A few mechanisms]. PMID- 9951742 TI - [Interrelation between the journal Medicina (Buenos Aires) and the Argentine Societies of Clinical Investigation and Immunology]. PMID- 9951743 TI - Essential clinical epidemiology in clinical education. PMID- 9951744 TI - Use of autologous fibrin glue in dermatologic surgery: application of skin graft and second intention healing. AB - OBJECTIVE: To evaluate the efficiency of biological sealant, an autologous fibrin glue, in dermatological surgery. DESIGN: Randomized clinical trial. SETTING: The Dermatology Service of Hospital das Clinicas, Universidade de Campinas (UNICAMP), referral center. PATIENTS: 14 patients with malign epithelial cutaneous tumors participated in the evaluation, each having two tumors, generally facial and symmetrical, in order to perform a comparative evaluation on the same individual. PROCEDURES: The glue was prepared beforehand with a sample of autologous blood. Surgical extirpation of the tumor was followed by grafts or second intention healing. OUTCOMES: The efficiency of the sealant was then evaluated in relation to hemostasis, adhesion, surgical time and evolution of the granulation tissue, clinically and histologically. RESULTS: Immediate hemostasis and graft adhesion, with a significant reduction of surgical time, and in the open wounds there was immediate hemostasis and a clinical increase in granulation tissue, but with no histological differences among the groups on the 7th day. CONCLUSION: It is an adjuvant resource in skin cancer surgery. PMID- 9951746 TI - Anticardiolipin antibody in recurrent spontaneous aborting and fertile women. AB - OBJECTIVE: To determine the association between the presence of anticardiolipin antibody and a history of recurrent spontaneous abortion. STUDY DESIGN: Clinical controlled study. LOCATION: Department of Gynecology and Obstetrics-University of Campinas (UNICAMP). SUBJECTS: 52 individuals with recurrent spontaneous abortion were included in Group 1 and 104 individuals with at least one live born child in Group 2. Elapsed time from last delivery to blood sampling varied from six months to two years. METHOD: Between November 1993 and November 1994, patients' blood samples were screened for anticardiolipin antibody by ELISA, as described by Triplett, Barna and Unger (1993). ANALYSIS: Chi-square and Fisher's Exact tests were used for statistical analysis. Student's "t" test was used to compare the means. RESULTS: There was no statistical difference in the presence of the anticardiolipin antibody between Group 1 (zero and 2.9%) and Group 2 (7.7 and 5.8%). CONCLUSION: There was no association between the presence of anticardiolipin antibody and recurrent spontaneous abortion. PMID- 9951745 TI - In vivo metabolism of alpha-tocopherol in lipoproteins and liver: studies on rabbits in response to acute cholesterol loading. AB - OBJECTIVE: To investigate the transport of alpha-tocopherol in lipoproteins of rabbits under normal diet and under acute loading of cholesterol. DESIGN: Two New Zealand White rabbits were fed 14C-alpha-tocopherol acetate in a single oral dose and the recovery of radiolabel in lipoproteins and plasma was monitored. Low density lipoprotein (LDL) from these animals was obtained and labeled with [3H] cholesteryl ester. Three other rabbits were injected with this double-labeled LDL in the native form; while three other animals received this LDL in the acetylated form. RESULTS: Plasma clearance, liver uptake and levels of radiolabel in high density lipoprotein (HDL) of animals injected with 14C[3H]acetyl LDL were significantly higher than those in animals injected with 14C[3H]native LDL. Larger particles of HDL, rich in apolipoprotein E (apoE) carried significantly higher levels of both labels in rabbits injected with acetylated LDL. CONCLUSION: These results provide evidence for in vivo mechanisms of "reverse alpha tocopherol transport", analogous to "reverse cholesterol transport". PMID- 9951747 TI - Overweight and obesity among mothers of malnourished children--Brazil--PNSN- 1989. AB - OBJECTIVE: To evaluate the relationship between the nutritional status of the youngest child under 48 months of age (in families with the biological mother present) and their mothers among 3906 children selected from a sample of a national survey in 1989 (PNSN). RESULTS: Malnutrition was present in 5.8% of the children. From these, 21.8%, 60.9% and 17.3% had overweight/obese, eutrophic and malnourished mothers, respectively. Stratified analyses taking into account the regions, situation, income distribution and mother's educational level demonstrated that a lower proportion of malnourished children was concurrent with a higher proportion of overweight/obese mothers. The Kappa test evidenced a poor agreement between the nutritional conditions of the child-mother pairs (K < = 0.048). CONCLUSIONS: When the proportion of malnourished children decreased within the analyzed groups, the proportion of overweight/obese mothers increased. Such an epidemiological pattern indicates that within groups in which malnutrition is less prevalent, the proportion of children for whom a lack of food in the household is the main determinant factor for malnutrition is lower. PMID- 9951748 TI - Seasonal variation of blood pressure in maintenance hemodialysis. AB - CONTEXT: Seasonal variation in arterial blood pressure has been reported in studies with hypertensive and normotensive subjects. However, the influence of seasonal change on blood pressure of hemodialysis patients has not been reported. OBJECTIVE: To investigate the seasonal variation of blood pressure in Brazil, a tropical country, in patients on hemodialysis. DESIGN: Prospective, cohort study. SETTING: Dialysis unit of a tertiary medical center (a teaching hospital of the University of Sao Paulo School of Medicine, Sao Paulo). PATIENTS: Sixteen patients with chronic renal failure undergoing hemodialysis. OUTCOMES: Blood pressure, body weight, and ambient temperature were evaluated during 6 hemodialysis sessions carried out on 13 days during the four seasons. RESULTS: The diastolic blood pressure was lower in summer than in fall and winter (95 +/- 8 vs 107 +/- 10 and 101 +/- 10 mmHg, respectively; p < 0.05). The same was observed with mean blood pressure (116 +/- 8 vs 130 +/- 11 and 124 +/- 9 mmHg, respectively; p < 0.01). On the other hand, the ambient temperature was higher in summer than in fall and winter (23.0 +/- 1.6 vs 19.5 +/- 3.0 and 15.8 +/- 1.9 degrees C, respectively; p < 0.01). CONCLUSIONS: We concluded that for patients with chronic renal failure the blood pressure has a seasonal variation with higher pressures in fall and winter than in summer. Thus, further studies are needed to elucidate the impact of this observation on the adjustment of antihypertensive treatment and on morbidity and mortality in maintenance dialysis patients. PMID- 9951749 TI - Primary melanoma of the uterine cervix figo stage III B. AB - The primary malignant melanoma of the uterine cervix is rare, usually diagnosed at an advanced stage and with poor prognosis. The diagnosis is made through histological evaluation and confirmed by special staining procedures. Radical surgery has been used and advocated. However in its advanced stages chemotherapy, immunotherapy or radiotherapy can be employed. A case of a patient with malignant melanoma of the uterine cervix, Stage IIIb, is presented in addition to a clinical and pathological discussion. PMID- 9951750 TI - Large intestine obstruction complicated with perforation: a rare manifestation of Schistosoma mansoni infection. AB - The authors report a case of a 25 year old Brazilian man with a history of crampy abdominal pain in the left iliac fossa for 2 weeks, abdominal distention, mucous diarrhea and anorexia. The patient presented signs of hemodynamic instability and a hard mass palpated in the left iliac fossa presented peritoneal irritation. At laparotomy, fecal peritonitis and a punched-out perforation of the midsigmoid colon were found. A left hemicolectomy was performed with terminal colostomy. Specimen examination revealed a thickened rectosigmoid wall, narrow lumen and multiple mucosal polyps. Microscopically, chronic granulomatous colitis with Schistosoma mansoni eggs confirmed the etiology. To the authors' knowledge, this is the first case of obstruction complicated with perforation due to mansoni schistosomiasis reported in the literature. PMID- 9951751 TI - Problem-based learning: application and possibilities in Brazil. AB - The Ministry of Health launched the Family Health Program (FHP) with the aim of establishing comprehensive primary care for families and communities. The Public Health School of Ceara has been applying problem-based learning as the instructional method for the training of the family health teams. The importance of this method and the possibility of applying it in the implementation of a new and effective approach to the continuing education of Brazilian health professionals are emphasized. PMID- 9951752 TI - Immunolocalization of MP84 in renal biopsy sections of sickle cell nephropathy patients. PMID- 9951753 TI - Methodological aspects of prognostic factor studies: some caveats. PMID- 9951754 TI - Good common sense--quaint superstition. PMID- 9951755 TI - Validation of routine incidence reporting of one anaesthesia provider institution within a nation-wide quality of process assessment program. AB - In 1992, a long-term project was launched by the German Society for Anaesthesiology and Intensive Care Medicine to render quality comparisons between anaesthesia providers. As one of the first volunteer centres, we established the standardised reporting of perioperative anaesthesia related incidents, events, and complications (IEC) in any routine anaesthetic procedure performed. This present study is aimed to explore the longitudinal stability of IEC recordings in one institution, which should be a prerequisite for valid external comparisons. Methods. The analyses were completed on an adult population of 49945 consecutive anaesthetic procedures with peripheral surgery from July 1992 until December 1996. Attribute quality control charts with monthly samples of an average of 954 anaesthetics were used to assess statistical variability of specific IEC incidences. Results. Average proportions were 20% for moderate IEC, 2.7% for severe IEC, 13% for moderate cardio-vascular IEC, 1.3% for severe cardio-vascular IEC, and 2.4% for respiratory IEC. Moderate IEC proportions showed considerable variability during the study period. A series of excess proportions was probably due to educational activities on documentation discipline. In contrast, clinically severe IEC proportions were rather stable. Stability of cardio vascular IEC proportions resembled the picture of the overall IEC assessment. Monthly respiratory IEC proportions showed smallest variability during the study period. Discussion. Use of the quality control statistics is suitable to distinguish random from systematic influence on quality indicators. IEC recordings that are not specific in pathophysiologic type or are of low grade of clinical severity, are heavily dependent on systematic documentation features. We assume that peak values, such as in times of optimised documentation discipline, better reflect reality than average values because missing reporting is much more likely than false positives. PMID- 9951756 TI - Influence of pulse oximetry and capnography on time to diagnosis of critical incidents in anesthesia: a pilot study using a full-scale patient simulator. AB - OBJECTIVE: Many studies (outcome, epidemiological) have tested the hypothesis that pulse oximetry and capnography affect the outcome of anesthetic care. Uncontrollable variables in clinical studies make it difficult to generate statistically conclusive data. In the present study, we eliminated the variability among patients and operative procedures by using a full-scale patient simulator. We tested the hypothesis that pulse oximetry and capnography shorten the time to diagnosis of critical incidents. METHODS: A simulator was programmed to represent a patient undergoing medullary nailing of a fractured femur under general anesthesia and suffering either malignant hyperthermia, a pneumothorax, a pulmonary embolism or an anoxic oxygen supply. One hundred thirteen anesthesiologists were randomly assigned to one of two groups of equal size, one with access to pulse oximetry and capnography data and the other without. Each anesthesiologist was further randomized to one of the four critical incidents. Each anesthetic procedure was videotaped. The time to correct diagnosis was measured and analyzed. RESULTS: Based on analysis of 91 of the subjects, time to diagnosis was significantly shorter (median of 432 s vs. >480 s) for the anoxic oxygen supply scenario (p = 0.019) with pulse oximetry and capnography than without. No statistical difference in time to diagnosis was obtained between groups for the other three critical incidents. CONCLUSIONS: Simulation may offer new approaches to the study of monitoring technology. However, the limitations of current simulators and the resources required to perform simulator-based research are impediments to wide-spread use of this tool. PMID- 9951758 TI - Hydraulic analog for simultaneous representation of pharmacokinetics and pharmacodynamics: application to vecuronium. AB - OBJECTIVE: To facilitate teaching the pharmacologic determinants of clinically observed drug effect, we expand on the hydraulic representation of the pharmacokinetics and pharmacodynamics of intravenous drugs. INTRODUCTION: There are two significant barriers to understanding the pharmacological determinants underlying clinically observed drug responses. The first obstacle is the mathematical nature of traditional descriptions of these phenomena; the second barrier to understanding is that most educational texts focus solely on pharmacokinetics. However, pharmacokinetics alone do not explain the action at the effect site. The scientific and educational literature has used analogs of pharmacokinetic phenomena to make the concepts more intuitive. This manuscript extends the use of a hydraulic analog to include the effect site, allowing a simultaneous representation of pharmacokinetics and pharmacodynamics. METHODS: In the described hydraulic analog, fluid delivered into a central reservoir is representative of drug infusion, and the heights of the fluid columns in the central and peripheral reservoirs are representative of the drug concentrations in the corresponding pharmacologic compartments. The height of the fluid column in an 'effect reservoir' is representative of the apparent effect site concentration in a simultaneous pharmacokinetic-pharmacodynamic model. A non linear scale on the effect reservoir represents the relationship between the effect site concentration and the clinical effect. Reservoir surface areas are equivalent to volumes of distribution and hydraulic resistances are inversely proportional to drug clearances. The proof of mathematical equivalency of the presented analog to simultaneous pharmacokinetic-pharmacodynamic models is given in an appendix. ILLUSTRATION OF THE EDUCATIONAL APPLICATION: The effect window can represent monitored twitch response following the administration of a neuromuscular blocking agent. Using pharmacokinetic-pharmacodynamic parameter values for vecuronium, we demonstrate how the hydraulic analog can be used to explain the priming principle and the clinically observed time-course disparity of two effect sites: the larynx and the adductor pollicis. (A companion web site: http://www.anest.ufl.edu/ha.html presents an interactive animation of the described analog.) PMID- 9951757 TI - Normothermic cardiopulmonary bypass increases heparin requirements necessary to maintain anticoagulation. AB - OBJECTIVE: With the practice of warm cardiopulmonary bypass (CPB) at our institution we have observed an apparent increase in heparin requirements. CPB temperature predictability affects pharmacokinetics and differences in drug metabolism can be expected. We hypothesized that heparin requirements would increase with increasing CPB temperature. METHODS: Following Institutional Review Board approval, we reviewed the charts of 354 patients undergoing primary coronary artery bypass graft surgery. We recorded patient demographic data, CPB duration, heparin requirements, and temperature during CPB. CPB was conducted between 24 degrees C and 37 degrees C. The Spearman's correlation coefficient, Pearson chi-square, and rank-sum tests were used for data analysis. RESULTS: Core temperature during CPB correlated with heparin requirements (r = 0.13, p < 0.02). However, CPB duration was shorter in warm patients than in cold patients (r = 0.455, p < 0.0001). Additional heparin requirements adjusted for duration of CPB (units/minute) were also significantly greater in the warm group (p = 0.018). CONCLUSIONS: Maintenance of adequate heparin anticoagulation during CPB is clinically important. Warm CPB patients required more heparin per minute than those undergoing cold CPB. More frequent assessment of anticoagulation and administration of additional heparin should be considered in patients undergoing warm CPB. PMID- 9951759 TI - Evaluation in volunteers of the VIA V-ABG automated bedside blood gas, chemistry, and hematocrit monitor. AB - OBJECTIVE: To evaluate the VIA V-ABG (VIA Medical Corp.) point-of-care blood gas and chemistry monitor in healthy human volunteers, with particular emphasis on the measurement of blood gases. METHODS: Experimental conditions were varied by intermittently subjecting volunteers to either isocapnic hypercapnia (end-tidal (ET), PETCO2 = 50+/-2 mmHg, ETPO2 = 130+/-5 mmHg) or isocapnic hypoxia (PETCO2 = 42+/-2, PETO2 + 45+/-2 mmHg) in addition to room air breathing. Measurements by the VIA V-ABG device were compared with paired samples and measurements performed by two ABL Radiometers (505 and 500). Analysis of results includes bias and precision plots and comparison of results with minimal performance criteria as established by CLIA. RESULTS: Nineteen volunteers yielded 222 matched samples. The range of values were 7.32-7.61 for pH, 20.9-51.6 mmHg for PCO2, 27.9-184.5 mmHg for PO2, 134-141 mmol/l for Na, 3.1-4.1 mmol/l for K, and 30.0-50.4% for hematocrit. Bias and precision (+/-2 sd) for pH was 0.01 and 0.04, for PCO2 was 0.4 and 4.8, for PO2 was 1.0 and 17.0, for Na was -0.3 and 5.2, for K was 0.1 and 0.2, and for Hct was 2.0 and 5.4. CONCLUSIONS: Over the range of blood gas values assessed, blood gas measurements by the VIA V-ABG device were clinically acceptable and met minimal performance criteria utilizing current Medicare CLIA proficiency standards. Performance criteria were also met by the VIA V-ABG device for Na, K, and Hct measurements but the range of values was too narrow to allow characterization of clinical acceptability. The VIA V-ABG device appears to perform well compared with the results which have been published for other point of-care devices. Comparison between different studies investigating point-of-care devices is difficult due to several factors (range of values measured, comparison device, population studied, etc.). Some of these instruments, including the VIA V ABG device, may serve quite well as point-of-care devices to perform certain tests at the bedside. Whether or not any of these devices can substitute for traditional laboratory blood gas and chemistry measurements remains an issue that is not adequately studied. PMID- 9951760 TI - Sampling intervals to record severe hypotensive and hypoxic episodes in anesthetised patients. AB - OBJECTIVE: To define the longest sampling interval which will faithfully record the time course of episodes of severe hypotension and hypoxia in anesthetised patients. METHODS: Electronic anesthetic records of 1501 patients were analyzed retrospectively for hypotension where measured systolic blood pressure fell to 60 mmHg or less, and for hypoxia where SpO2 fell to 80% or less. The onset and offset times, maximum rate of change and spectral content were calculated for each episode. RESULTS: These episodes commonly were rapid in onset and offset. The longest sampling interval to accurately represent these data was calculated to be 36 s for invasive blood pressure and 13 s for pulse oximetry. CONCLUSIONS: Our current anesthetic record is inadequate to record many of the severe changes that we observed. One minute recording intervals, such as used in many electronic record keeping systems, are too slow to capture the rapid rates of change seen, and may lead to the assumption that an episode was not recognized promptly or that treatment was not administered in a timely manner. PMID- 9951761 TI - Sensitivity of near infrared spectroscopy to cerebral and extra-cerebral oxygenation changes is determined by emitter-detector separation. AB - OBJECTIVE: To examine the effect of two emitter-detector separations (2.7 and 5.5 cm) on the detection of changes in cerebral and extra-cerebral tissue oxygenation using near infrared spectroscopy (NIRS). METHODS: Two NIR detectors were placed on the scalp 2.7 and 5.5 cm from a single NIR emitter. Changes in deoxyhaemoglobin (HHb), oxyhaemoglobin (O2Hb),oxidised cytochrome C oxidase (Cyt) and total haemoglobin (tHb) were recorded from each detector during the induction of cerebral oligaemia (transition from hypercapnia to hypocapnia) and scalp hyperaemia (following release of a scalp tourniquet). RESULTS: Cerebral oligaemia (mean decrease in middle cerebral artery blood flow velocity of 44%) induced by a mean reduction in end tidal CO2 of 18 mmHg was accompanied by a significant increase in the spectroscopic signal for HHb and a decrease in the O2Hb signal. The signal change per unit photon path length detected at 5.5 cm was significantly greater for HHb (p = 0.007) than that detected at 2.7 cm. In contrast, the increase in all chromophores detected at 5.5 cm during scalp hyperaemia was significantly less than that detected at 2.7 cm (p<0.001). CONCLUSIONS: The differing sensitivity of the proximal and distal channels to changes in cerebral and extracerebral oxygenation is compatible with theoretical models of NIR light transmission in the adult head and may provide a basis for spatially resolving these changes. The optimal emitter-detector separation for adult NIRS requires further investigation and may differ between individuals. PMID- 9951762 TI - Artifact mistaken for electrical interference recorded from a pulmonary artery catheter. AB - Artifactual signals superimposed on the electrocardiogram have been well documented [1-5]. These signals can originate from infusion pumps [1, 2], occlusion heads from cardiopulmonary bypass machines [3,4], and dialysis apparatus [5]. Artifacts on a pulmonary artery tracing, such as those produced by "catheter whip," are well described [6], and rarely if ever confuse the clinician. Extraneous electrical signals are of major concern because they pose a hazard to susceptible patients. We report a case in which the blood pressure tracing from the pulmonary artery revealed an artifact that looked at first glance like 60 cycle alternating current (AC) electrical interference. The investigation as to its origin revealed important lessons in the analysis of human error. PMID- 9951763 TI - Pro: is pulse oximetry still worthwhile? PMID- 9951764 TI - Con: is pulse oximetry still worthwhile? PMID- 9951765 TI - Effect of ketamine on bispectral index and levels of sedation. PMID- 9951767 TI - Dynamic contrast-enhanced MR imaging of the entire breast with spectral-selective inversion fast three dimensional sequence. AB - Dynamic contrast-enhanced images with high spatial and temporal resolutions were acquired with a fast 3D spoiled gradient echo (SPGR) sequence using spectral selective inversion recovery (IR) pulse. Five healthy volunteers and 12 patients with 14 pathologically proven breast lesions were studied. Fat suppressed volume image data covering the entire breast were obtained with a sufficient spatial resolution (0.9 x 1.5 x 3.0 mm3) and an imaging time of 57 s. By using the criteria including peripheral enhancement and presence of spiculation, sensitivity, specificity, and accuracy in detecting malignant lesions were 88.9, 80.0 and 85.7%, respectively. Although the C/N and S/N ratios were approximately 30% less than those of the conventional fat suppressed 3D technique, fast 3D SPGR imaging with spectral IR method demonstrated sufficient image quality for both time intensity analysis and morphological evaluation of the breast lesions with a data acquisition time less than half of the conventional method. This technique can substantially improve spatial and temporal resolutions of dynamic MR images of the breast and will be useful in evaluating malignant and benign breast lesions. PMID- 9951766 TI - In vivo 300 MHz longitudinally detected ESR-CT imaging in the head of a rat treated with a nitroxide radical. AB - In vivo longitudinally detected ESR (LODESR)-CT system operating at 300 MHz was developed, based on the combination of a bridged loop-gap resonator and a pair of saddle-type pickup coils (STPCs). The sensitivity distribution of the STPCs was simulated on the basis of a magnetic dipole model. A LODESR-CT image of a phantom (a physiological saline solution of a nitroxide radical) was satisfactorily corrected by using the simulation result. LODESR-CT images of the head of a rats, in which nitroxide radical was injected intraperitonally, were also obtained through the correction in the same manner. This is the first in vivo CT (i.e. three-dimensional imaging) study with a 300 MHz ESR. PMID- 9951768 TI - Detection of colorectal liver metastases: prospective comparison of unenhanced and ferumoxides-enhanced magnetic resonance imaging at 1.5 T, dual-phase spiral CT, and spiral CT during arterial portography. AB - The purpose of this study was to compare the efficacy of unenhanced and ferumoxides-enhanced magnetic resonance imaging with that of dual-phase spiral CT and spiral CT during arterial portography (CTAP) for the detection of colorectal liver metastases. Fourteen patients with liver metastases candidates for partial hepatectomy were examined with dual-phase spiral CT, unenhanced and ferumoxides enhanced MR imaging at 1.5 T, and spiral CTAP. Imaging tests were read blinded, prospectively, quantitating number of lesions excepting CTAP which used US to exclude cysts. Subsequent intraoperative US and pathologic findings were correlated with preoperative imaging results. At surgery, 36 lesions 0.5-13 cm in diameter (mean+/-standard deviation, 2.9+/-2.1 cm) were identified. Dual-phase spiral CT depicted 21/36 (58%); precontrast MR imaging, 19/36 (53%); ferumoxides enhanced MR imaging, 30/36 (83%); and spiral CTAP, 34/36 (94%) lesions. Ferumoxides-enhanced MR imaging was significantly more sensitive than spiral CT and unenhanced MR imaging (P < 0.01). The difference in sensitivity between ferumoxides-enhanced MR imaging and spiral CTAP was not statistically significant (P> 0.1). Spiral CTAP, however, depicted nine false-positive lesions (2 hemangiomas, 7 perfusion defects). The positive predictive value was 79% for spiral CTAP and 100% for combined pre- and postcontrast MR imaging. We conclude that ferumoxides-enhanced MR imaging is superior to unenhanced MR imaging and biphasic spiral CT for depiction of colorectal liver metastases. Further investigation is needed to clarify whether MR imaging with use of ferumoxides might replace spiral CTAP for preoperative evaluation of liver resection candidates. PMID- 9951769 TI - Influence of pulse angle variations on stimulated echo acquisition mode proton nuclear magnetic resonance spectra of AB spin systems: theory and experiments with citrate. AB - The influence of pulse angle variations in the localization sequence stimulated echo acquisition mode (STEAM) on the signal of strongly coupled AB spin systems has been examined. Experimental 1H nuclear magnetic resonance (NMR) spectra of citrate were recorded on a 1.5 T whole-body imager. Theoretically calculated spectra were generated, with good correlation to experimental results. The dependence of the signal intensity on sequence timing and pulse angles was calculated analytically. For longer sequence timings, the ratio of the signal intensity from citrate to the signal intensity from uncoupled nuclei depends strongly on the applied flip angles. The shape of spectra also changes with varying flip angles. These effects are clearly less pronounced for STEAM than for point resolved spectroscopy (PRESS). The results have to be considered for quantitative measurements of citrate in spectroscopic investigations as, e.g. of prostate neoplasms. PMID- 9951771 TI - A method of RF inhomogeneity correction in MR imaging. AB - A direct postprocessing method for correcting RF inhomogeneity in MR imaging is proposed. First, two images with different flip-angles of theta and 2theta are obtained. Next, the spatial distribution maps of the sensitivity of the surface coil and the B1 field intensity are produced by employing those images. Finally, the correction of the MR image is achieved, dividing the original image by distribution maps of the coil sensitivity and the B1 field intensity. The method was applied to images obtained by a gradient echo sequence and the corrected image is presented. PMID- 9951772 TI - Carbon-centered radicals as oxygen sensors for in vivo electron paramagnetic resonance: screening for an optimal probe among commercially available charcoals. AB - It is known that some charcoals possess paramagnetic centers with an electron paramagnetic resonance (EPR) linewidth which can be broadened by oxygen. In order to identify potential candidates as sensors for in vivo EPR oximetry, we carried out a systematic study among commercially available charcoals. A total of 34 charcoals were tested. The steps used for the screening were: (1) to check the presence of paramagnetic centers in the material; (2) to measure the EPR linewidth in nitrogen and in air on the dry material and on a aqueous suspension of particles; (3) to calibrate the oxygen sensitive materials (EPR linewidth vs. pO2); (4) to test the sensitivity and stability of the response to changes of pO2 in a simple model of hypoxia induced in mice. Seventeen charcoals contained paramagnetic centers detectable by low-frequency EPR (1.1 GHz). The EPR spectrum consist of one single line which is typical of carbon-centered radicals (g-factor approximately 2). Eight charcoals presented sufficient interesting EPR properties (linewidth in nitrogen < 0.1 mT, linewidth in air for an aqueous suspension of particles > 0.15 mT) to be further characterized in vivo. Only three charcoals presented a stable, reproducible, and sensitive response to pO2 for more than 2 months. These three coals should be considered as good candidates to be used as oxygen sensor using in vivo EPR spectroscopy. PMID- 9951770 TI - 1H MR spectroscopy in patients with mesial temporal epilepsy. AB - The study provides a review of the basic examination procedures and results of proton magnetic resonance spectroscopy (1H MRS) in patients suffering from mesial temporal lobe epilepsy (MTLE). The source of seizures in MTLE is most often an epileptogenic focus secondary to hippocampal sclerosis. 1H MRS currently plays an important role in the non-invasive diagnosis of this type of epileptogenic lesion. The decisive 1H MRS parameter characterizing an epileptogenic lesion is a statistically significantly decreased value of N-acetylaspartate levels compared with control values, most often associated with a decrease in the ratios of the intensities of NAA/Cr, NAA/Cho and NAA/(Cr + Cho) signals. Moreover, MRS makes it possible to distinguish bilateral involvement of mesial temporal structures typically associated with a bilateral decrease in the levels of metabolites and/or their ratios. As regards other metabolic compounds which play an important role in the pathobiochemistry of epilepsy, MRS is employed to study the action of gamma-aminobutyric acid (GABA), inositol, lactate, glutamine, and glutamate, the clinical function of which has not been fully clarified as yet. It is in this context that one should consider the application of 1H MRS in evaluating the action of some new anti-epileptic agents affecting excitatory and inhibitory amino acids. There is no doubt that in vivo 1H MRS, along with other imaging methods, has made a significant contribution to the clinical and biochemical description of epileptic seizures and has assumed a prominent position among the techniques of pre-operative examination in epileptic surgery. PMID- 9951773 TI - Additive effect of voluntary exercise and growth hormone treatment on bone strength assessed at four different skeletal sites in an aged rat model. AB - The aim of the study was to assess the effect of growth hormone (GH), voluntary exercise (Ex), and the combination of GH and Ex on bone strength, mass, and dimensions in aged, intact female rats. In addition, the effect of food restriction (FR) was studied. Fourteen-month-old virgin F-344 rats were divided into 6 groups with 13 animals in each: (1) baseline (BSL); (2) control + solvent vehicle (CTRL); (3) GH 2.5 mg/kg/day (GH); (4) exercise, voluntary: 0.6-0.7 km/day (Ex); (5) GH treatment and voluntary exercise (GH + Ex); and (6) FR. Group 1 was killed at the beginning of the study and served as baseline. All the other groups were killed after 18 weeks' treatment. The effects of aging and treatment regimes were measured at four different skeletal sites: lumbar vertebrae, femoral cortical bone, femoral neck, and the distal femoral metaphysis. Aging in itself induced a decline in vertebral body strength and ash density. At the appendicular skeletal sites, bone mass and strength were unchanged or increased. Treatment with GH alone induced a significant increase in the biomechanical parameters at the vertebral body and the femoral diaphysis, but not at the femoral neck or the distal femoral metaphysis. Voluntary exercise on its own increased load values significantly over CTRL at the vertebral body site, but not at any of the appendicular skeletal sites. The combination of GH and voluntary exercise resulted in an additive effect at the vertebral site and at the femoral diaphysis, and a synergistic (potentiating) effect at the two femoral metaphyses. FR, on the other hand, had a negative effect on cortical bone area and strength at the femoral diaphysis, but no significant effect on the other sites tested. We conclude that GH treatment and voluntary exercise both have skeletal anabolic effects; however, these effects are exerted to differing degrees at different sites. Importantly, when dosed together, GH and Ex have either an additive or synergistic anabolic effect on all sites (axial and appendicular). PMID- 9951774 TI - Recombinant growth hormone accelerates bone regenerate consolidation in distraction osteogenesis. AB - The purpose of the present study was to prove whether homologous GH has a stimulating effect on bone healing. Therefore, left tibiae of 30 micropigs were osteomized and distracted over an external fixator at the rate of 2 mm/day on each of 10 consecutive days. Animals were killed after a healing period of another 10 days. The treatment group received 100 microg of recombinant porcine growth hormone (rpGH) per kilogram of body weight per day. Serial torsional nondestructive biomechanical tests were performed in vivo using a newly developed measurement device. After killing, destructive torsional strength testing of the sites of distraction was performed. To determine the endocrine response to the administration of rpGH, serum levels of insulin-like growth factor-I (IGF-I) were determined. Nondestructive in vivo testing showed that torsional stiffness of the regenerate was significantly higher in the treatment group than in the control group. Final regenerate torsional failure load was 131% higher and ultimate torsional stiffness was 231% higher in the treatment group than in the control group. The mean serum level of IGF-I increased to 440% of preoperative basal level in the treatment group and remained unchanged in the control group. Our data indicate that systemic administration of recombinant homologous growth hormone greatly accelerates ossification of bone regenerate in distraction osteogenesis. PMID- 9951775 TI - Enhanced osteoblast development after continuous infusion of hPTH(1-84) in the rat. AB - Rats and humans respond to intermittent treatment with parathyroid hormone (PTH) with increased bone density and cancellous bone volume. In the rat, osteoblast expression of insulin-like growth factor-I (IGF-I) is elevated by intermittent PTH. We examined the effect of continuous infusion of rhPTH(1-84), a bone catabolic regime, on the IGF system in rat pelvis. Female Sprague-Dawley rats (12 weeks, 250 g) were randomly assigned to receive 0, 0.1, 1, or 5 microg/100 g body weight (b.w.) rhPTH(1-84) (0, 0.106, 1.06, or 5.305 nmol/kg) in vehicle (1% normal rat serum in saline) delivered by subcutaneous Alzet minipump. After 7 days, blood was taken for serum chemistry and pelvises were processed for immunocytochemistry. Sections of pelvis from rats continuously infused with 0.1 or 1 microg/100 g b.w. rhPTH(1-84) for 7 days did not differ significantly from those of the vehicle-treated controls. However, continuous infusion of 5 microg/100 g b.w. rhPTH(1-84) resulted in a dramatic increase in cellular development, with trabeculae surrounded by many layers of large, plump osteoblasts. All pelvis osteoblasts expressed osteocalcin, but only those from rats that received 0, 0.1, or 1 microg/100 g b.w. rhPTH(1-84) showed positive staining for IGF-I. The extra-abundant osteoblasts from rats that received 5 microg/100 g b.w. rhPTH(1-84) did not stain for IGF-I. However, although all osteoblasts stained positively for IGF binding proteins (IGFBPs)-3, -4, and -5, staining for these IGFBPs increased as the dose of rhPTH(1-84) (and osteoblast number) increased. These results suggest that continuous infusion of PTH has a direct effect on osteoblast development (either recruitment or proliferation), decreases the expression of IGF-I, and enhances the expression of IGFBPs in pelvis, factors which may interact to bring about negative bone balance. PMID- 9951776 TI - Parathyroid hormone stimulates cancellous bone formation at skeletal sites regardless of marrow composition in ovariectomized rats. AB - The purpose of the current report is to compare the skeletal effects of PTH treatment at red (hematopoietic) and yellow (fatty) marrow sites in ovariectomized (ovx) rats. In the first study, mature, slowly growing ovx rats that were 4 months of age and 4 weeks postovariectomy were treated with human parathyroid hormone [hPTH(1-34)] (80 microg/kg, 5 days/week) for 6 weeks. In the second study, aged ovx rats that were 15 months of age and 1 year postovariectomy were treated with PTH according to the same regimen for 10 weeks. The proximal tibial metaphysis (PTM) and first lumbar vertebra (LV), bone sites with red marrow, as well as the distal tibial metaphysis (DTM) and fifth caudal vertebra (CV), bone sites with yellow marrow, were processed undecalcified for quantitative bone histomorphometry. At the end of the first study in mature ovx rats, estrogen depletion induced a 73% loss of cancellous bone in the PTM and a 15% loss in the LV. In contrast, not even a trend for cancellous bone loss was observed in the DTM and CV of vehicle-treated ovx rats. PTH treatment of ovx rats increased cancellous bone volume by 191% in the PTM, 56% in the DTM, 47% in the LV, and 22% in the CV, compared with vehicle treatment of ovx rats. In addition, the hormone markedly increased cancellous bone formation by 177% in the PTM, 679% in the DTM, 309% in the LV, and 833% in the CV. Aged ovx rats (second study) exhibited moderate cancellous osteopenia in the LV but not the CV. PTH treatment increased cancellous bone volume by 67% and 37% and bone formation rate by 635% and 359% in the LV and CV, respectively, compared with vehicle treatment of ovx rats. Although the magnitude of the anabolic response to PTH may vary somewhat within the skeleton, the results indicate that PTH augments cancellous bone mass and markedly stimulates bone formation at skeletal sites, regardless of marrow composition. PMID- 9951777 TI - Use of peripheral quantitative computed tomography for densitometry of the femoral neck and spine in cynomolgus monkeys (Macaca fascicularis). AB - Quantitative computed tomography (QCT) allows for the separate densitometric examination of cortical and cancellous bone in vivo. With the new peripheral QCT (pQCT) instrument (the Norland/Stratec XCT-3000A), we evaluated the clinically relevant axial sites of spine and femoral neck in nonhuman primates in vivo. The reproducibility was good (coefficient of variation [CV] <3% at both sites for cortical, trabecular, and total bone mineral density [BMD]; CV 3%-7% for bone mineral content [BMC] and cross-sectional bone area). One hundred sixty intact female cynomolgus monkeys (M. fascicularis) were scanned at the femoral neck. There was less variability among monkeys in cortical BMD (mean 802 mg/mL, CV 6%) as opposed to trabecular BMD (mean 334 mg/mL, CV 28%) or transition zone BMD (mean 457 mg/mL, CV 12%). Scans were performed on lumbar vertebrae (L-4, L-5, and L-6) from five monkeys in vivo and ex vivo. Removal of soft tissue increased measured BMD. Decreasing voxel size from 0.4 mm to 0.2 mm increased measured BMD by diminishing the partial volume effect. Factor analysis demonstrated the expected relationships between pQCT parameters and physical measurement of bone mass and volume ex vivo. Preliminary results in eight ovariectomized and eight reproductively intact monkeys revealed a lower transition zone BMD at the femoral neck, and lower total BMD of the vertebral body in estrogen-deficient animals. PMID- 9951778 TI - Calcified cartilage morphometry and its relation to subchondral bone remodeling in equine arthrosis. AB - The calcified layer of articular cartilage is known to be affected by age and mechanical factors that may play a role in the development of arthrosis. Because these factors are also related to subchondral remodeling and sclerosis, a morphometric study was carried out in fluorochrome-labeled animals to determine whether the level of subchondral remodeling affected the thickness of the calcified cartilage layer and its irregularity and vascularity at the interface with subchondral bone. These parameters were also studied at a site of increased mechanical stress. The area and thickness of the calcified cartilage layer was determined in basic fuchsin-stained ground sections (120 microm). The irregularity of the chondro-osseous interface was expressed as the ratio of its length to that of the relatively straight tidemark (Int/Tid) and the number of abutting vessels with and without fluochrome labels were counted (N.Ves/Tid,%L.Ves/Tid). These were compared with single-labeled surface (sLS/BS, %) in subchondral bone, which was used as an index of remodeling. In a group of 12 horses, in which one carpus had an osteochondral fragment surgically created 10 weeks earlier, there was activation of subchondral remodeling in the third carpal bone opposite the fragment. An increase in %L.Ves/Tid (p < 0.01) at the interface was correlated with the increase in %sLS/BS in subchondral bone (r=0.431, p=0.035). The number of abutting vessels and the interface irregularity were not significantly changed on the fragmented side. In the metacarpal condyles from the fetlock joints of the same horses there were no differences associated with the surgically created fragment in the carpus and no correlation of %L.Ves/Tid with subchondral %sLS/BS. At a site where mechanical overload and traumatic osteochondrosis is known to occur on the palmar surface, the calcified cartilage was thinner, and the interface irregularity tended to be greater. These findings indicate that activated subchondral remodeling extends to involve the calcified layer, but the thickness and irregularity of the calcified cartilage are not consistently related to current subchondral remodeling. At sites of mechanical overload the calcified cartilage was thinner and the interface tended to be more irregular, suggesting previous increased remodeling. PMID- 9951779 TI - Connectivity and the elastic properties of cancellous bone. AB - This study addresses the possible significance of trabecular connectivity for the mechanical quality of cancellous bone. A total of 141 cubic trabecular bone specimens collected from autopsy material from 56 individuals without any known bone or metastatic diseases were used. Age variation was in the range of 14-91 years and a wide range of trabecular architecture was found. Each specimen was three-dimensionally reconstructed with a voxel size of either 20 or 25 microm. Using the detailed three-dimensional reconstructions as input for microstructural finite-element models, the complete elastic properties of the trabecular architecture were obtained and maximum and mean stiffness could be calculated. Volume fraction and true three-dimensional architectural measurements of connectivity density and surface density were determined. Connectivity density was determined in an unbiased manner by the Euler number, which is a topological property. Using multiple regression analysis it was found that volume fraction explained by far the greatest part (84%-94%) of the variation in both mean and maximum stiffness. When connectivity density and surface density were included, the correlations increased marginally to 89%-95%. Noticeably negative regression coefficients were found for connectivity density. The results suggest that, in normal cancellous bone, the connectivity density has very limited value for assessment of elastic properties by morphological variables, but if a relation exists then stiffness decreases with increasing connectivity. PMID- 9951780 TI - Does estrogen stimulate osteoblast function in postmenopausal women? AB - How estrogen therapy influences bone metabolism in postmenopausal women has previously been studied using several approaches, including bone densitometry, measurement of biochemical markers of bone turnover, and histomorphometry. Taken together, these investigations suggest that conventional doses of estrogen protect from bone loss predominantly through suppression of bone resorption, with little evidence to suggest that a stimulatory action on osteoblasts is also involved. In contrast, studies of patients treated with estradiol implants suggest that, following prolonged exposure to relatively high estrogen levels, an additional stimulatory effect on osteoblast function is observed. The suggestion that estrogen stimulates osteoblast activity in postmenopausal women under certain circumstances is consistent with other evidence that estrogen is an important physiological regulator of osteoblast activity. Furthermore, these findings raise the possibility that it may be useful to develop strategies for treating postmenopausal osteoporosis that aim to reproduce the stimulatory action of relatively high estrogen levels on bone formation in postmenopausal women. PMID- 9951781 TI - Intramuscular clodronate therapy in postmenopausal osteoporosis. AB - Long-term daily administration of oral bisphosphonates has been effective in the treatment of postmenopausal osteoporosis, but the duration, mode and cost of the therapy may sometimes affect patient compliance. In Italy, the bisphosphonate clodronate is also available via the intramuscular (i.m.) route of administration, and the present study was performed to test its efficacy in postmenopausal osteoporosis. Ninety osteoporotic postmenopausal women were enrolled in a randomized, controlled 3 year study. The diet of all patients was adjusted to provide 1200-1300 mg of calcium daily, eventually by administration of supplements. Patients were randomly assigned to no therapy (30 patients) or to receive clodronate 100 mg i.m. either every 2 weeks (30 patients) or 1 week (30 patients). The i.m. injection caused substantial pain at the site of injection, which led to treatment withdrawal in almost 50% of the patients receiving weekly dosing. In control patients, a progressive, slow decline in spine and femoral bone mineral density (BMD), which became statistically significant at the end of the second year of observation, was observed. In the patients given weekly i.m. clodronate, spinal BMD rose by 3.8% (+/-7.3 SD) within 6 months. A slight, nonsignificant increase was observed thereafter, such that, at the completion of 3 years of observation, the mean gain was 4.5% (+/-6.3). In the patients treated with injections of 100 mg of clodronate every two weeks the increase in BMD was somewhat lower and slower, becoming significant only at month 24 (2.9+/-4.6%). In none of the two active groups was the femoral neck BMD changed significantly during the 3 years of the study. A significant increase in trochanter and Ward's triangle BMD was observed at month 12 only in the patients on the highest dose of clodronate. In both groups treated, the hip BMD changes were significantly different from those observed in control patients. The biochemical markers of bone turnover were suppressed in both clodronate groups. These results indicate that intermittent i.m. clodronate administration can provide clinically relevant benefits to skeletal bone density in osteoporotic postmenopausal women, but the in situ pain may limit its extensive use. PMID- 9951782 TI - Long-term consequences of fracture of the lower leg: cross-sectional study and long-term longitudinal follow-up of bone mineral density in the hip after fracture of lower leg. AB - The purpose of this study was to investigate whether bone loss in the hip, occurring after a fracture of the lower leg, persists many years after the fracture. In a long-term follow-up we measured bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) of both hips and the lumbar spine in a group of 11 patients, 5 years after a fracture of the lower leg. These patients were part of an earlier study, evaluating bone loss in the hip, up to 1 year after fracture of the lower leg. In this follow-up study, 5 years after fracture, loss from baseline BMD in the trochanteric region of the ipsilateral hip was 4.7% (p=0.04), whereas after a year in this group there was a decrease of 12.5% from baseline. On the contralateral side, hardly any change occurred. In the ipsilateral femoral neck, 5 years after fracture, BMD decreased by 2.9% (p=0.10), after 1 year loss from baseline was 5.1%. In a cross-sectional study we examined the differences in BMD of both hips, measured by DXA, in a group of 19 elderly patients reporting a fracture of the lower leg, with a mean time of 9.3 years after fracture. In this study, we found a 4.7% lower BMD in the trochanteric region of the hip on the fractured side compared with the nonfractured side (p=0.006), and a 2.9% lower BMD in the femoral neck (p=0.25). We conclude that, after fracture of the lower leg, BMD in the ipsilateral hip decreases significantly, with maximal bone loss after 1 year. After 5 years recovery has occurred, but not to baseline. Thereafter, significant excess bone loss is still observed in the trochanteric region. This persisting lower BMD may lead to an increased risk of another fracture in later years. PMID- 9951783 TI - Lack of an intronic Sp1 binding-site polymorphism at the collagen type I alpha1 gene in healthy Korean women. AB - Osteoporosis is a disease that is strongly genetically influenced. However, the genes responsible for the disease are poorly defined. Recent data show that a G-T transition polymorphism of the Sp1 binding site at the collagen type I alpha1 gene (Sp1 polymorphism) is associated significantly with bone mineral density (BMD) and osteoporotic fracture in British women. To establish the association between the Sp1 genotypes and BMD in Korean women, we examined 200 healthy postmenopausal women of Korean ethnicity, ranging in age from 44 to 66 years (mean+/-SD: 54.7+/-5.3 years). PCR amplification using the same primers as those used previously, with enzyme digestion, revealed no restriction site in our samples. We also performed a single-strand conformational polymorphism (SSCP) analysis in 100 of the 200 samples and could not find any polymorphic sites in the PCR amplification region. Based on our study, the Sp1 polymorphism at the type I collagen alpha1 gene was not found in Korean women. Therefore, we suggest that the Sp1 polymorphism at the type I collagen alpha1 gene is absent or rare in Korean women. Based on the present findings, this polymorphism does not seem to be responsible for the entire genetic contribution to BMD. PMID- 9951784 TI - Prevention of appendicular bone loss in Paget's disease following treatment with intravenous pamidronate disodium. AB - It has been shown previously that intravenous pamidronate treatment for severe Paget's disease is associated with appendicular bone loss. This 2 year study was designed to determine whether cotreatment with calcitriol and a calcium supplement would prevent this. Intravenous pamidronate was used to treat 49 patients with symptomatic Paget's disease. Patients were stratified into two groups of differing biochemical severity based on hydroxyproline excretion (HypE) expressed as micromoles per liter of glomerular filtrate (GF): (1) a severe group with HypE > 10 micromol/L GF; and (2) a moderate group with HypE 5-10 micromol/L GF. Within each group, patients were randomly allocated to receive supplements of calcium and calcitriol (supplemented) or no supplements (unsupplemented) after initiation of pamidronate therapy. The severe group received 360 mg of pamidronate as six doses of 60 mg once weekly and the moderate group received 240 mg as four weekly doses of 60 mg. Patients were followed for 24 months following treatment and had serial bone densitometry of the forearm measured as well as urine and plasma biochemistry. When the groups were combined, the unsupplemented patients showed a decrease in bone mineral density (BMD) at the ultradistal forearm site, which persisted to 24 months. Those supplemented with calcium and calcitriol showed an increase in BMD and the difference between the two groups was significant at all times posttreatment (p < 0.03). When the groups were analyzed separately, those with moderate disease again showed significant differences in BMD between supplemented and unsupplemented patients at all timepoints. In the severe group, the differences did not reach statistical significance due to smaller patient numbers. Similar changes in BMD were also observed at the forearm shaft site. When serial parathyroid hormone (PTH) levels (with the moderate and severe groups combined) were plotted against time since treatment the rise in PTH in the supplemented patients was less than the rise in the unsupplemented patients (p < 0.04). These results suggest that forearm bone loss after intravenous pamidronate treatment for moderate-to-severe Paget's disease can largely be prevented by administration of calcium and calcitriol. The mechanism may be a blunting of the secondary hyperparathyroidism that occurs after intravenous pamidronate. These findings may have wider application in moderate-to-severe Paget's disease treated with other bisphosphonates. PMID- 9951785 TI - Bone metabolic changes in Antarctic wintering team members. AB - Bone mass, bone metabolic markers, and calcium regulation hormones were measured in members of an Antarctic wintering team who stayed at the Japanese Antarctic station, Syowa (latitude: south 69 degrees 00', longitude: east 39 degrees 35') for 1 year. Subjects included 31 healthy Japanese males, aged 24-51 years (mean age 34.5 years) at the beginning of this study, ingesting 488 IU/day of vitamin D and 550.9 mg/day of calcium per person. The long-term coefficient of variation (CV) of the equipment used in the assessments of bone mass was 0.67% in single X ray absorptiometry (SXA), 0.17% in the speed of sound (SOS) by quantitative ultrasound method (QUS), and 0.63% in broadband ultrasound attenuation (BUA) by QUS. The seasonal changes in the calcaneal bone mineral density (BMD) by SXA were not significant, whereas the SOS measured by QUS decreased during the measurement period (0.55%, p < 0.001), and BUA increased (1.9%, p < 0.01). Bone-specific alkaline phosphatase and osteocalcin levels increased significantly during summer (p < 0.001) and urinary calcium level decreased significantly during winter (p < 0.05). Urinary pyridinoline and deoxypyridinoline levels decreased significantly at the end of winter (p < 0.001). Serum 1,25(OH)2D3 level did not change significantly, whereas serum 25(OH)D3 level decreased significantly during winter (p < 0.001). Serum parathyroid hormone (PTH) level significantly increased at the end of winter (p < 0.01), although both PTH level and 25(OH)D3 level remained within the normal range. We concluded that the 25(OH)D3 level in subjects who stayed in Antarctica for 1 year decreased significantly with the reduction in duration of sunshine, but there were no clear changes in bone mass. PMID- 9951786 TI - Epidemiological study of hip fracture in Shenyang, People's Republic of China. AB - The aim of this study was to investigate the incidence and epidemiology in 1994 of hip fracture in Shenyang, a large city in the northeast of The People's Republic of China, using register information and medical records collected from the 36 hospitals in Shenyang. The hip fracture data were restricted to cervical or trochanteric types. A subset (59% of total) of medical records of hip fracture was used to investigate the causes of hip fracture. The causes were classified as simple fall, fall from a bicycle during cycling, bicycle accident, car accident, and fall from a height. There was a total of 453 hip fractures (206 in women and 247 in men) in the population over 50 years of age. The age-adjusted 1 year cumulative incidence rate was 67/100,000 (95% confidence interval [CI] = 58 76/100,000) for women and 81/100,000 (95% CI = 71-91/100,000) for men. The standardized incidence rate against the 1985 U.S. population was 87/100,000 (95% CI = 77-97/100,000) for women and 100/100,000 (95% CI = 89-111/100,000) for men. The mean (+/-standard deviation) age of patients with a hip fracture was 67.5+/ 9.8 years for men and 66.9+/-9.0 years for women. The overall male-to-female ratio of hip fracture was 1.21:1 for age-adjusted hip fracture incidence and 1.15:1 for standardized incidence. Simple fall accounted for 70% hip fractures in women but caused only 49% in men (chi2 = 11.2, degrees of freedom [df] = 1,p = 0.0008). The frequency of hip fractures caused by a fall from a bicycle was higher in men (28%) than women (10%) (chi2 = 13.0, df = 1,p = 0.0003). The results of this study indicate (1) a low incidence of hip fracture in a Chinese population compared with more affluent countries, and (b) a higher incidence in men than women that is related in part to a higher incidence of accidents, especially bicycle-related ones. PMID- 9951787 TI - A case of McCune-Albright syndrome mimicking Paget's disease of bone. PMID- 9951788 TI - Uptake of seven myocardial tracers during increased myocardial blood flow by dobutamine infusion. AB - RATIONALE AND OBJECTIVES: Direct comparison of myocardial perfusion tracers has been made difficult by variability in experimental models, and by a virtual absence of data comparing tracer uptake to myocardial blood flow under conditions of increased myocardial oxygen consumption, similar to what occurs with dynamic exercise. METHODS: Tracer uptake versus myocardial blood flow was evaluated for thallium-201 (201TI) and six technetium-99m (99mTc) myocardial-imaging agents in 24 open-chest canines with an occluded left-anterior descending coronary artery during dobutamine infusion. Data were fitted to the exponential model y = ax(1 - exp[-PSc/x]), where y is the tissue tracer/g normalized to normal (activity at 1 mL/minute/g) and x is the blood flow measured by the radioactive microsphere method. RESULTS: With dobutamine, myocardial tracer uptake was linear across a wide range of ischemic and hyperemic flows for each tracer. Based on the permeability surface area product, 201TI and 99mTc Q3 provided the best tracer estimate of myocardial blood flow (5.30+/-0.86 mL/minute/g, r = 0.91; 5.46+/-0.58 mL/minute/g, r = 0.94, respectively). Correlation coefficient (r) values for other tracers studied were 99mTc Q4 (r =0.93), 99mTc Q12 (r = 0.93), 99mTc sestamibi (r = 0.90), 99mTc tetrofosmin (r = 0.96), and 99mTc-N-Noet (r = 0.82). CONCLUSIONS: Of the 99mTc tracers examined under conditions of dobutamine-altered myocardial contractility, the myocardial uptake properties of 99mTc Q3 were most similar to those of 201TI. PMID- 9951789 TI - Experimental hepatobiliary fascioliasis in rabbits: a radiology-pathology correlation. AB - RATIONALE AND OBJECTIVES: The authors sought to correlate the radiologic findings of hepatobiliary fascioliasis with pathologic features. METHODS: Serial ultrasound, computed tomography (CT), and magnetic resonance findings in seven rabbits with experimentally induced fascioliasis were obtained every other week. Direct cholangiogram was also obtained after the rabbits were killed. Radiology pathology correlation was done in specimens. RESULTS: In the parenchymal phase (an acute phase of parenchymal invasion of a larva), CT showed subcapsular clustered areas of low attenuation. Magnetic resonance appearance was similar in shape but better than CT in characterizing the hemorrhagic nature of the lesion. Ultrasound findings were nonspecific in this phase. In the ductal phase (a stationary phase after residing in the bile duct), CT showed dilatation of central ducts with symmetric periportal hypoattenuation (periportal tracking). Magnetic resonance could not depict mild ductal dilatation. Ultrasound was most valuable in demonstrating the moving worm within the dilated duct. Pathologically, the hepatic parenchymal lesions consisted of a cluster of eosinophilic granulomas with hemorrhagic change (migratory tract of the flukes). Ductal changes were observed predominantly in the central bile ducts. Periportal lymphangiectasia was also noted. CONCLUSIONS: Computed tomography or magnetic resonance can demonstrate the characteristic evolutionary pattern of fascioliasis that reflects the unique life cycle of Fasciola hepatica. The role of ultrasound, although limited in the parenchymal phase, was most useful in the ductal phase in that it demonstrated the moving worms themselves. PMID- 9951791 TI - Dynamic phosphorus-31 magnetic resonance spectroscopy of the quadriceps muscle: effects of age and sex on spectroscopic results. AB - RATIONALE AND OBJECTIVES: Phosphorus-31 (31p) magnetic resonance spectroscopy (MRS) is used to assess the influence of sex and age on quadriceps muscle metabolism before and after exercise. METHODS: Fifty-four healthy volunteers and 56 patients with an arterial occlusive disease were examined by dynamic 31p MRS. In the magnet, the quadriceps muscle was stressed by an isometric and an isotonic form of exercise until exhaustion. RESULTS: Older subjects showed a significantly larger ratio of inorganic phosphate (P(i)) to phosphocreatine (PCr) than younger subjects (r = 0.52, P = 8 x 10(-9)). With subjects' increasing age, the ratio of adenosine triphosphate (beta-ATP) to total phosphate decreased (r = -0.36, P = 5 x 10(-5)). The ratio of phosphomonoester to beta-ATP and phosphodiester (PDE) to beta-ATP showed a strong age dependence (r = 0.71 and 0.69, P = 3 x 10(-17) and 4 x 10(-15), respectively). The pH was the only one of the evaluated spectroscopic parameters that showed a sex dependence. Female subjects had a significantly lower pH (7.03+/-0.02) than male subjects (7.05+/-0.03) (P = 6 x 10(-4)). With increasing age, the maxima of P(i) to PCr were less extreme during both of the exercises (r = -0.51, P = 3 x 10(-16)). Likewise, the exercise-induced acidosis was less severe with increasing age (r = -0.51, P = 7 x 10(-16)). After the exercises ended, the times of half recovery of P(i) to PCr and the pH neither correlated with the subjects' age nor with sex or the cross-sectional area of the quadriceps muscle. CONCLUSIONS: The sex and age of volunteers or patients may affect spectroscopic results in a significant way. This influence has to be considered in the interpretation of spectroscopic studies. According to the recovery rates of P(i) to PCr and the pH, an age-related deterioration of muscular metabolism seems to be avoidable by appropriate physical activity. PMID- 9951790 TI - D-galactose-based signal-enhanced color Doppler sonography of breast tumors and tumorlike lesions. AB - RATIONALE AND OBJECTIVES: This study sought to evaluate prospectively the diagnostic potential of unenhanced and enhanced color Doppler and power Doppler for the differentiation of tumors and tumorlike lesions of the breast. METHODS: Ninety-two patients with 110 tumors or tumorlike lesions of the breast were investigated by unenhanced and enhanced color and power Doppler ultrasound. The sonomorphologic aspects of vascularization were analyzed. In addition, maximal systolic frequency shift, resistance, and pulsatility indices were determined. RESULTS: In 15 (24%) of 63 primary carcinomas, 15 (68%) of 22 fibroadenomas, and all (100%) of 14 postoperative lesions, the sonomorphologic analysis for the differential diagnosis of breast tumors was improved after contrast enhancement in color Doppler mode. In comparing unenhanced color Doppler to power Doppler, the latter was found to be slightly superior (sensitivity, 60% vs. 67%; specificity, 39% vs. 45%, respectively); after enhancement, both modes were equivalent (sensitivity, 100% vs. 100%; specificity, 95% vs. 95%, respectively). Signal enhancement resulted in a significant improvement in sensitivity and specificity (P < 0.01). Typical signs of malignancy were irregular vessel calibers, serpiginous courses, penetration of the tumor's margin, and irregular reticular vascularization. The quantitative parameters proved not to be helpful for the differential diagnosis of breast tumors. CONCLUSIONS: By improved analysis of the vascularization pattern, d-galactose-enhanced color Doppler sonography was found to provide more reliable differential diagnostic information than unenhanced Doppler ultrasound in tumors and tumorlike lesions of the breast. PMID- 9951792 TI - Gadolinium neutron capture therapy (GdNCT) of melanoma cells and solid tumors with the magnetic resonance imaging contrast agent Gadobutrol. AB - RATIONALE AND OBJECTIVES: The therapeutic gain of neutron capture therapy with a neutral macrocyclic gadolinium (Gd) complex (Gadobutrol) was evaluated through in vitro and in vivo studies in a beam of low-energy neutrons. METHODS: Neutron irradiation for both the in vitro and in vivo studies was performed in a beam of low-energy neutrons produced by the research reactor of the Hahn-Meitner Institut, Berlin. Malignant melanoma cells of human origin were irradiated in the presence or absence of Gadobutrol. In vivo irradiation was performed on tumor bearing nude mice. The tumor site was irradiated subsequent to intratumoral injection of Gadobutrol and compared with irradiation in the absence of the Gd complex. RESULTS: In vitro studies showed a Gd-dependent delay of cell proliferation as a consequence of neutron irradiation. In animals, intratumoral administration of the Gd complex at a dose of 1.2 mmol Gd/kg before neutron irradiation results in a significant delay in tumor growth with respect to the control groups. CONCLUSIONS: In vitro and in vivo studies showed a therapeutic benefit with the neutral Gd complex and suggest Gd-containing magnetic resonance contrast media are potential candidates for neutron capture therapy. The Gd dose used in the irradiation experiments was four times the presently accepted high dose in clinical magnetic resonance imaging. PMID- 9951793 TI - Fast fluid-attenuated inversion recovery (FLAIR) compared with T2-weighted spin echo in the magnetic resonance diagnosis of mesial temporal sclerosis. AB - RATIONALE AND OBJECTIVES: The authors compare coronal fast fluid-attenuated inversion recovery (FLAIR) with coronal T2-weighted spin-echo (SE) magnetic resonance (MR) techniques in the diagnosis of mesial temporal sclerosis (MTS). METHODS: In this prospective study, the authors assessed MR scans of 30 patients with drug-resistant temporal lobe epilepsy (based on clinical symptomatology and electroencephalographic registrations) with MR features suggestive of MTS. MR scans of age-, sex-, and scanner-matched patients, referred for MR assessment of white matter disease, without a history of epilepsy and with no visible abnormalities on MR, were used as controls. In 16 patients the MR diagnosis was confirmed by histologic abnormalities consistent with MTS. Coronal T2 SE and FLAIR images of patients and controls were presented to two experienced radiologists in random order for independent blinded review. Hippocampal and associated extrahippocampal temporal lobe abnormalities were used for the diagnosis of MTS. RESULTS: The sensitivity of observer A was 97% for the T2 SE sequence and 100% for the FLAIR; the specificity of observer A for both techniques was 100%. The sensitivity of observer B was 53% for T2 SE and 83% for FLAIR; the specificity for observer B was 93% for the T2 SE and 100% for FLAIR. CONCLUSION: Coronal FLAIR images provide a similar or increased yield in the detection of MTS compared with T2-weighted SE images. PMID- 9951794 TI - Usability of semiautomatic segmentation algorithms for tumor volume determination. AB - RATIONALE AND OBJECTIVES: Tumor volume is an important parameter for clinical decision making. At present, semiautomatic image segmentation is not a standard for tumor volumetry. The aim of this work was to investigate the usability of semiautomatic algorithms for tumor volume determination. METHODS: Semiautomatic region- and volume-growing, isocontour, snakes, hierarchical, and histogram-based segmentation algorithms were tested for accuracy, contour variability, and time performance. The test were performed on a newly developed organic phantom for the simulation of a human liver and liver metastases. The real tumor volumes were measured by water displacement. These measured volumes were used as the gold standard for determining the accuracy of the algorithms. RESULTS: Variability of the segmented volumes ranging from 3.9 +/- 3.2% (isocontour algorithm) to 11.5 +/ 13.9% (hierarchical segmentation) was observed. The segmentation time per slice varied between 32 (volume-growing) and 72 seconds (snakes) on an IBM/RS6000 workstation. CONCLUSIONS: Only the region-growing and isocontour algorithms have the potential to be used for tumor volumetry. However, further improvements of these algorithms are necessary before they can be placed into clinical use. PMID- 9951795 TI - Gas dynamics in CO2 angiography: in vitro evaluation in a circulatory system model. AB - RATIONALE AND OBJECTIVES: The use of carbon dioxide (CO2) as a vascular contrast agent has increased significantly since the introduction of digital subtraction angiography. To optimize the injection of CO2 for digital subtraction angiography, we evaluated the gas dispersion patterns from differing catheter designs, gas flow dynamics, and the influence of vessel size and inclination on luminal gas filling. METHODS: A circulatory system model was constructed and perfused with 36% glycerin solution at a rate of 1.08 to 1.13 liters per minutes (pulse rate 72 beats/minute, pressure 90-111 mm Hg). Fifty milliliters of CO2 was rapidly injected into the vascular tube of the model (diameter 6.4-15.9 mm) at an inclination of 0 degrees to 45 degrees via a catheter, and imaged digitally in a cross-table lateral projection. The dispersal patterns of gas bubbles from the halo, pigtail, and end-hole catheters were evaluated as well as the degree of luminal gas filling. RESULTS: The halo and end-hole catheters produced continuous gas flow with homogeneous density. The pigtail catheter produced smaller bubbles with inhomogeneous density. Luminal gas filling was incomplete, with a residual fluid level posteriorly regardless of the size and inclination of the tube. At 0 degrees inclination, gas filling was greater with the 6.4-mm tube than with the 15.9-mm tube. With an inclination of 0 degrees to 15 degrees, gas filling was significantly improved for the larger tubes. On dispersal, CO2 bubbles rapidly coalesced and moved forward along the anterior aspect of the tube. The frontal motion of the bubble was parabolic in configuration. CONCLUSIONS: The halo and end-hole catheters provide more homogeneous gas density than the pigtail catheter. Gas filling was incomplete regardless of catheter design, vessel size, or inclination. Inclination improves gas filling in vessels > 12.7 mm in diameter. PMID- 9951796 TI - Evaluation of gadopentetate dimeglumine magnetic resonance cisternography in an animal model: preliminary report. AB - RATIONALE AND OBJECTIVES: To evaluate magnetic resonance (MR) imaging characteristics of the cisternal administration of gadopentetate dimeglumine (gadolinium) in a small experimental animal. METHODS: Four female New Zealand White rabbits were used for this experiment. Each rabbit received a single dose of intrathecal gadolinium (doses ranged from 75-100 micromol) via a cisternal puncture. Immediate and delayed sagittal and axial T1-weighted images of the brain and cervical spinal cord were acquired on a 2 Tesla CSI magnet. RESULTS: All the rabbits tolerated the experiment well, without significant alterations in behavior or seizure activity. During the early phase of imaging, subarachnoid space enhancement was observed over the surface of the brain parenchyma and spinal cord on T1-weighted images. Gradual diffusion of the gadolinium into the cranial parenchyma was seen on the delayed MR studies (45 minutes-6 hours), as revealed by progressive generalized enhancement of the brain. Sustained enhancement of gray matter of the spinal cord was observed. CONCLUSION: This study illustrates that there is no barrier between the cerebrospinal fluid (CSF) and the brain-spinal cord with regard to gadolinium. Possible practical applications for gadolinium-enhanced MR myelography or cisternography include the assessment of communication or obstruction of CSF pathways, subarachnoid space CSF flow pattern analysis, spontaneous or acquired CSF fistula evaluation, evaluation of the intercommunication of central nervous system cystic structures bordering on CSF pathways, and the study of the dynamics of gadolinium diffusion in the central nervous system parenchyma. PMID- 9951797 TI - Hepatic microcirculatory changes induced by hepatic artery embolization in rats: original investigation. AB - RATIONALE AND OBJECTIVES: To evaluate the effects of hepatic artery embolization (HAE), hepatic microcirculatory changes induced by HAE were assessed quantitatively in rats. METHODS: Using in vivo microscopy, the blood-flow velocity (BFV) through terminal portal venules (TPVs) and terminal hepatic venules (THVs) was measured during HAE with gelatin sponge powder (GSP), iodized oil (Lipiodol, 0.1, 0.2, and 0.4 mL/kg), or 0.1 mL/kg Lipiodol followed by GSP. RESULTS: After HAE with GSP, BFV through TPVs decreased significantly, but BFV through THVs did not decrease. After HAE with Lipiodol (0.2 and 0.4 mL/kg), BFV through TPVs decreased significantly, but BFV through THVs did not. After HAE with Lipiodol followed by GSP, BFV through both TPVs and THVs decreased significantly. CONCLUSIONS: Neither GSP nor Lipiodol adversely affects hepatic microcirculation when administered alone; however, HAE with a combination of Lipiodol and GSP does adversely affect hepatic microcirculation. PMID- 9951798 TI - Takayasu arteritis, Buerger disease and inflammatory abdominal aortic aneurysms: is there a common pathway in their pathogenesis? AB - Takayasu arteritis, Bueger disease and IAAA are non-specific vasculitis involving mainly large vessels, the etiology of which are all still in the mist. Our recent HLA analysis on Takayasu arteritis and Buerger disease revealed a close association with some HLA antigens which made us suppose the common pathological pathway to cause these morbid conditions. International survey on Takayasu arteritis also revealed cases involving abdominal aorta only (Type IV, International Classification) in Asian countries, very similar to clinical and pathological features of IAAA. These ongoing survey suggest the common mechanism in the pathophysiology of these morbid conditions. PMID- 9951799 TI - Pathology of isolated nonclassical and catastrophic manifestations of Takayasu arteritis. AB - Takayasu arteritis is usually defined as a chronic, progressive, inflammatory, occlusive disease of the aorta and its branches. However, we should remind Takayasu arteritis as a systemic disease. Here I describe nonclassical and catastrophic manifestations of the Takayasu arteritis, which often go unrecognized until after the event. Especially I stress that we should focus on cardiopulmonary complications in Takayasu arteritis. PMID- 9951800 TI - Increased levels of soluble forms of adhesion molecules in Takayasu arteritis. AB - The present series of experiments were designed to determine if soluble forms of vascular cell adhesion molecule-1 and inter cellular adhesion molecule-1 are elevated in the setting of Takayasu arteritis. Plasma levels of these soluble adhesion molecules were measured by enzyme-linked immunosorbent assay in 73 Takayasu arteritis and 36 age-matched normal controls and examined with respect to the age of patients. Soluble vascular cell adhesion molecule-1 levels were significantly higher in Takayasu arteritis (mean 871.4 ng/ml, P<0.01) compared with controls (mean 607.9 ng/ml). No difference was found in soluble inter cellular adhesion molecule-1 levels between these two groups. Comparison of soluble vascular cell adhesion molecule-1 and inter cellular adhesion molecule-1 in these patients subdivided by age into three groups indicated significantly higher levels of these molecules in individuals over 50 years old compared to those under 39 years old (P<0.05). These data suggest that the measurement of soluble vascular cell adhesion molecule-1 may be clinically important in Takayasu arteritis. The correlation of soluble vascular cell adhesion molecule-1 and inter cellular adhesion molecule-1 levels with age may indicate some relationship with progression of this disease. PMID- 9951801 TI - Vasculitis-susceptible genes in mice with a deficit in Fas-mediated apoptosis. AB - Autoimmune diseases show complex pathological manifestations, which frequently involve systemic vasculitis. This complication is understood to be a manifestation of advanced disease, or to represent distinct entities, restricted by genetic and/or environmental factors. An MRL/Mp strain of mice bearing the Fas deletion mutant gene, lpr (MRL/lpr), spontaneously develop systemic vasculitis coincidentally with glomerulonephritis, arthritis and sialoadenitis, but a C3H/HeJ-lpr/lpr (C3H/lpr) strain does not. Thus, this is a suitable model for analyzing the genetic basis of vasculitis in autoimmune diseases. To genetically dissect these complex pathological manifestations, a linkage analysis of each lesion with polymorphic microsatellite markers was performed by using MRL/lpr x (MRL/lpr x C3H/lpr)F1 backcross mice. Vasculitis-susceptible gene loci were mapped on chromosomes 3 and 4, which were not associated with glomerulonephritis, arthritis and sialoadenitis. These results indicate that systemic vasculitis in MRL/lpr mice may be under the control of host genes which are different from those for other autoimmune diseases. PMID- 9951802 TI - Atherosclerosis and inflammation mononuclear cell recruitment and adhesion molecules with reference to the implication of ICAM-1/LFA-1 pathway in atherogenesis. AB - Recent investigations have reanimated the view that there exists a possible link between atherosclerosis and inflammation. Adhesion of monocytes as well as T lymphocytes to the arterial endothelial surface, followed by their migration into the subendothelial space is a hallmark for experimental animals fed an atherogenic diet. Human studies show identical features in the arterial wall to the animal models of atherosclerosis. The recruitment of leukocytes into areas of inflammation is mediated by interacting sets of cell adhesion molecules. In atherosclerosis, focal expression of key adhesion molecules particularly triggered by plasma atherogenic lipoproteins has been detected, and these molecules may mediate the recruitment of mononuclear cells to the plaque. Among these adhesion molecules, ICAM-1, a protein of the Ig superfamily, and one of the ligands for LFA-1 have been suggested to play an important role in atherogenesis. In diet-induced hypercholesterolemic rats, we found that ICAM-1 expression is up regulated mainly in lesion-prone areas of the aorta during the early stages of atherogenesis. Increased ICAM-1 expression was associated with a marked monocyte and T lymphocyte intimal recruitment. Further immunohistochemical studies have demonstrated that LFA-1 is expressed by more than 85% of macrophages in the lesions, and their presence therefore may point toward the involvement of the LFA 1/ICAM-1 receptor ligand pathway in the recruitment of mononuclear cells in the lesions. In order to verify this hypothesis, systemic administration of blocking antibodies was attempted; injection of anti-ICAM-1/LFA-1 monoclonal antibodies significantly reduced macrophage adherence and their emigration into the intima. Our current study suggests that ICAM-1 may act as an "athero-ELAM" for mononuclear cell intimal recruitment during atherogenesis. PMID- 9951803 TI - Effects and mechanism of tissue-type plasminogen activator and plasminogen activator inhibitor on vascular smooth muscle cell proliferation. AB - Smooth muscle cell (SMC) proliferation and migration play a pivotal role in restenosis following angioplasty. The expression of tissue-type plasminogen activator (tPA) increased significantly during SMC proliferation and migration in rabbit iliac artery injury model. In this experiment, the relationship of tPA, PAI-1 and vascular SMC proliferation was studied in vitro using human aortic smooth muscle cells cultivated in normal lipid or high lipid serum. The expression of certain oncogenes during the SMC proliferation was detected by Northern blot. RESULTS: tPA stimulates vascular SMC proliferation in a dose dependent manner, and the effect is increased significantly in high lipid environment. PAI-1 inhibits the mitogenic effect of tPA to SMC and is dose dependent. tPA increases oncogene c-myc mRNA level during SMC proliferation, and the level of c-myc mRNA increases significantly in hyperlipidemia. These findings indicate that tPA directly promotes human vascular SMC proliferation in vitro, and may contribute to intimal SMC proliferation after vascular injury by increasing the expression of oncogene c-myc mRNA. PMID- 9951804 TI - Demographic, clinical, and angiographic data of patients with Takayasu arteritis in Brazil. AB - We collected clinical, demographic, and angiographic data of Takayasu arteritis (TA) patients followed at Rheumatology Division of three Public University Centers (UNIFESP, USP, and UNICAMP) located in Sao Paulo State, Brazil. Clinical and demographic data were obtained from 73 patients (61 female; 50 white) The mean age at time of diagnosis was 27 y.o. and the mean follow-up time was 5 years. The following clinical features were observed along the evolution of these patients: absent or reduced pulses in upper limbs (85%), arterial bruit (64.5%), claudication of upper members (57%), headache (45%), hypertension (35.5%), dizziness (29%), cardiac bruit (29%), weight loss (27.5%), arthralgia or arthritis (26%), fever (24.5%) and claudication of lower limbs (20.5%). According to new angiographic classification of Takayasu arteritis performed in 28 patients followed at UNTFESP, with routine full aortography, 21% were classified as type I, 4% as type IIa, 4% as type III, 14% as type IV and 57% as type V. No patients had type IIb. Patients with Takayasu arteritis in Sao Paulo State Brazil showed female predominance and arterial involvement pattern similar to the one observed in Japan, with more than 20% classified as type I with exclusive involvement of the branches from the aortic arch. PMID- 9951805 TI - Takayasu arteritis in Colombia. AB - Takayasu arteritis has been recognized in Colombia just recently, and so far we do not have any report concerning its presentation here. In this first report, some issues related to the presentation of the disease are indicated and compared with those found in the medical literature. No differences were found in age and sex. Most of the cases were diagnosed during an inactive phase of the disease with advanced manifestations due to vascular lesion which suggests the existence of some genetic factor influencing such a presentation, or may be the consequence of a delay in diagnosing the disease during initial and active stages due to not suspecting it. Comparing the vessels which are affected among other races and countries, we can find both differences and similarities. With the purpose of discovering the demographic, clinical, angiographic and laboratorial characteristics of Takayasu arteritis in Colombia, the present study was carried out by studying 35 clinical cases in different medical centers of the country. PMID- 9951806 TI - A possible role of sex in determining distribution of lesions in Takayasu Arteritis. AB - Sixty-nine female and 43 male patients of Takayasu Arteritis (TA) were analysed based on their clinical and angiographic features. Clinical manifestations included hypertension in 41 (95%), bruits in 37 (86%) and hypertensive retinopathy in 28 (65%) male patients as compared to 47 (68%), 45 (65%) and 39 (56%) female patients respectively. An increased number of male patients (11.6%) had higher serum creatinine than female patients (1.6%). Angiographic evaluation suggested that female patients had involvement of ascending aorta, arch and abdominal aorta in six (8.6%), 14 (20.5%) and 37 (53.6%) patients respectively as compared to six (13.6%), five (11.6%) and 34 (79.1%) male patients. This data suggests that Indian male patients with TA have a higher frequency of hypertension and abdominal aorta involvement while female patients have a tendency towards involvement of aortic arch and its branches. PMID- 9951807 TI - An autopsy study of Takayasu arteritis in India. AB - Autopsy findings of 10 patients with Takayasu arteritis (TA) are presented. These patients include six females and four males with a mean age of 22.6+/-10.2 years. Hypertension was the commonest mode of presentation. On autopsy, the vascular lesions in the aorta comprised of stenosis (eight), dilatation (six), aneurysm (two) and dissection of aorta involving its arch, thoracic and abdominal aorta (one). Abdominal aorta was the commonest site of involvement (nine patients) and renal artery was involved in six patients. Histologically, the three types of lesions were identified--active, fibrotic and combination of active and fibrotic lesions. Active inflammatory lesions in the arterial circuit were present despite a clinically chronic (silent) phase of the disease. Cardiac involvement included left ventricular hypertrophy (nine), right ventricular hypertrophy (four), biventricular hypertrophy (three), myocarditis (two) (rheumatic and Takayasu's myocarditis--one patient each) and involvement of coronary artery (one). The pulmonary artery was involved in two patients. Kidneys showed changes of malignant hypertension and benign nephrosclerosis in one patient each. Associated tuberculosis was present in four patients. The causes of mortality were congestive heart failure (four), chronic renal failure (two), intracranial bleed, aneurysmal rupture and pulmonary thromboembolism in one patient each. Thus, the major causes of morbidity and mortality in Indian patients with TA is due to severe uncontrolled hypertension and its effect on heart, kidney and brain. The disease appears to have a persistent activity for a prolonged period even when it appears to be clinically silent. PMID- 9951808 TI - Molecular analyses of HLA class II-associated susceptibility to subtypes of autoimmune diseases unique to Asians. AB - It is well known that individuals positive for particular HLA-class II alleles show high risks for the development of Takayasu arteritis and other diseases caused by immunological disorders such as autoimmune diseases and allergies. HLA class II molecules present antigenic peptides to CD4+ T cells. Their extensive polymorphism affects the structures of peptides bound to HLA class II molecules to create individual differences in immune responses to antigenic peptides. To better understand the mechanisms for association between HLA class II alleles and susceptibility to autoimmune diseases, it is important to identify self-peptides presented by disease-susceptible HLA class II molecules and triggering disease causative T cells. Many autoimmune diseases are observed in all ethnic groups, whereas the incidences of diseases, clinical manifestations and disease susceptible HLA class II alleles are different among various ethnic groups for some autoimmune diseases. These phenomena suggest that differences in autoimmune self-peptide(s) in the context of disease-susceptible HLA class II molecules may cause these differences. Therefore, comparisons among disease-susceptible HLA class II alleles, autoimmune self-peptides and clinical manifestations of autoimmune diseases in different ethnic groups would be helpful in determining the pathogenesis of the diseases. In this paper, we describe our recent findings on: (1) the uniqueness of both clinical manifestations and HLA-linked genetic background of Asian-type (optico-spinal form) multiple sclerosis; (2) the structural characteristics of peptides bound to HLA-DQ molecules susceptible to insulin-dependent diabetes mellitus; (3) the identification of a disease-related autoantigenic peptide presented by disease-susceptible HLA-DQ molecules in Asians specific infant onset myasthenia gravis; and (4) a manipulation of human T cell response by altered peptide ligands, as a possible candidate for new and antigen specific immuno-suppressive therapy against autoimmune diseases. PMID- 9951810 TI - The association between the HLA antigens and Takayasu's arteritis in Thai patients. AB - The HLA-A, -B, -DR and -DQ antigen distribution in 20 unrelated Thai patients with Takayasu's arteritis was compared with that in 44 healthy controls. The frequency of HLA-A31 and HLA-B52 (chi2=4.54, P<0.05; chi2=3.80, P<0.05, RR=7.5) appeared to be increased in the patient group. In contrast, the frequency of HLA A24 and HLA-DQ3 (chi2=4.18, P<0.05, RR=0.25; chi2=5.36, P<.025, RR=0.28) appeared to be decreased in this group. PMID- 9951809 TI - MICA gene polymorphism in Takayasu's arteritis and Buerger's disease. AB - To further clarify the HLA-linked genes susceptible to arterio-vasculitis of unknown etiology, Takayasu's arteritis and Buerger's disease, polymorphism in the MICA gene, a newly identified gene near the HLA-B gene and expressed in epithelial cell lineage, was investigated. Polymerase chain reaction (PCR)-DNA conformation polymorphism (DCP) analysis and subsequent sequencing of the MICA gene have revealed that there are 5 MICA alleles which are different in the number of a GCT repeat in exon 5: MICA alleles MICA-1.1, -1.2, -1.3 and -1.4 have 9, 6, 5 and 4 GCT repeats, respectively, and MICA-1.5 has 5 GCT repeats with a 1 bp frameshift insertion in the repeat. MICA genotyping data in 81 Japanese patients with Takayasu's arteritis, 38 Japanese patients with Buerger's disease, and 160 healthy Japanese controls showed that MICA-1.2 and -1.4 were significantly associated with Takayasu's arteritis and Buerger's disease, respectively. Because MICA-1.2 and -1.4 were in strong linkage disequilibria with HLA-B52 and -B54 in the Japanese populations, respectively, we have compared the odds ratio (OR) of the risk to the diseases for individuals having both or each of the disease-associated MICA and HLA-B alleles. It was found that MICA-1.2 gave a significantly high OR of risk to Takayasu's arteritis in the absence of HLA B52, suggesting that the HLA-linked gene susceptible to Takayasu's arteritis is mapped near the MICA gene. In contrast, MICA-1.4 gave a significantly high OR of risk to Buerger's disease only in the presence of HLA-B54, suggesting that the HLA-linked gene susceptible to Buerger's disease is linked to the HLA-B54-MICA 1.4 haplotype, and may be differently mapped from that to Takayasu's arteritis. PMID- 9951811 TI - Association of clinical manifestations with HLA-B alleles in Takayasu arteritis. AB - HLA-DNA typing using PCR-SSOP and PCR-DCP methods was performed in 85 patients with Takayasu arteritis and 492 healthy controls who had been typed for HLA by serological method. Frequencies of HLA-B52 (B*5201) and B39 (B*3901 and B*3902) were significantly increased in the patients. Frequency of HLA-DRB1*1502 was also increased but it was suggested to be a reflection of its linkage disequilibrium with B52. Association of HLA-B52 and B39 with seven clinical manifestations- pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance--in 132 HLA-typed patients with Takayasu arteritis was studied. In HLA-B52 positive TA patients, aortic regurgitation (vs B52(-)-B39(+), OR=3.8, P<0.05, vs B52(-)-B39(-), OR=5.49, P<0.001), ischemic heart disease (vs B52(-) B39(+), OR=12.05, P<0.05, vs B52(-)-B39(-), OR=2.85, P<0.05), and pulmonary infarction (vs B52(-)-B39(+), OR=5.74, P<0.03) were found to be significantly prevalent. On the other hand, in HLA-B39 positive TA patients, frequency of renal artery stenosis was significantly increased (vs B52(+)-B39(-), OR=12.14, P<0.001, vs B52(-)-B39(-), OR=5.21, P<0.03). These observations have suggested that HLA B52 molecule and B39 molecule would contribute to different clinical manifestations by binding different antigenic peptides to cause inflammations. Thus HLA-B molecule may play an important role in pathogenesis or determining clinical manifestations of Takayasu arteritis. PMID- 9951812 TI - Immunogenetic analysis of Takayasu arteritis in Indian patients. AB - The distribution of HLA-A, B, C and DR antigens was determined in a cohort of 104 unrelated Indian patients with Takayasu arteritis (TA) belonging to the North Indian states of Punjab, Haryana, Uttar Pradesh and Delhi. The data was compared with healthy controls belonging to the same ethnic group. In addition, polymorphism in the MHC class I chain related A (MIC A) gene was studied in a group of 25 TA patients and 40 healthy controls. The data revealed a strong association of the disease with HLA-B5 (chi2=22.5, P<1 x 10(-6), RR=3.08) as well as its two common serological subtypes, B51 (chi2=20.5) and B52 (chi2=18.5). No particular association was observed with any of the five alleles of the MIC A gene, nor any linkage disequilibrium could be established with these alleles and those of HLA-B locus in this population. The observation suggest that HLA linked genes are definitely involved in the development of Takayasu arteritis and that the disease in Indian subjects is associated with HLA-B5 and its two serological subtypes, B51 as well as B52. PMID- 9951813 TI - Intron 2 and exon 3 sequences may be involved in the susceptibility to develop Takayasu arteritis. AB - We studied Major Histocompatibility Complex (MHC) Class I and Class II genes in seven Mexican Mestizo patients with Takayasu arteritis. Takayasu arteritis is an uncommon condition in Mexican Mestizo, however, previous studies report association of the disease in this population with Human Leukocyte Antigen (HLA) B39 and HLA-DRB1*1301. The results in the present study show that the haplotypes of the Mexican Mestizo patients with Takayasu arteritis are very heterogeneous, even when the disease is much more rare in Mexico than in Japan. The sequence analysis of HLA-B39 shows that Mexican patients exhibit the HLA-B*39061 and HLA B*39062 subtypes. These subtypes are more common in Mexico than in Japan, where the predominant subtype is HLA-B*3901. Interestingly, HLA-B*39061 and B-39062 share the 3' end of intron 2 and the 5' end of exon 3 with HLA-B*5101 and B*52012, alleles associated to Takayasu arteritis in Japanese. This fact suggests that Takayasu arteritis patients may share a specific sequence rather than a specific allele, even when the gene involved in the susceptibility to develop Takayasu arteritis may be a neighboring gene located between the genes related at present time with the disease, i.e. a gene located between MHC Class I and Class II regions. PMID- 9951814 TI - Ophthalmological findings in patients with Takayasu disease. AB - We examined 65 (61 female and 4 male) Takayasu patients. Patient age ranged from 17 to 78 years old (mean 50.2); age of onset was from 11 to 60 years old (mean 32.8); and duration from onset to referral ranged from 1 month to 43 years (mean 16.8 years). Routine ophthalmological examinations were performed. Fluorescein angiography, kinetic perimetry by Goldmann perimetry, static perimetry by Octopus 1-2-3, electroretinography (ERG), and measurements of central retinal arterial pressure were also performed, as appropriate. Major causes of impaired visual acuity (less than 16/20) were cataract. A few patients had low visual acuity caused by Takayasu disease itself. On the other hand, although not many complained of visual disturbance, about 35% of patients had subnormal visual functions. Because the visual deterioration may be based on ocular hypoperfusion, which may subsequently lead to more serious changes, regular ophthalmological examination for every Takayasu disease patient is recommended. PMID- 9951815 TI - The clinical application of 'edema-weighted' magnetic resonance imaging in the assessment of Takayasu's arteritis. AB - Takayasu's arteritis is an inflammatory process affecting medium to large arteries. In about half of cases, constitutional symptoms and laboratory studies do not correlate with disease activity, confounding therapeutic decision making. We present six representative cases of Takayasu's arteritis in which new magnetic resonance imaging sequences for improved morphological and tissue characterization were useful in identifying aortic wall thickening and acute inflammatory changes, respectively. Specifically, fast spin-echo sequences designed to enhance detection of vessel wall edema were included. This information proved useful in guiding clinical decision making, particularly in regard to initiation and monitoring of therapy in our patients. PMID- 9951816 TI - Takayasu arteritis: ultrasonographic evaluation of the cervico-cerebral arteries. AB - PURPOSE: To present the ultrasonographic findings of the cervico-cerebral arteries in patients with Takayasu arteritis. MATERIALS AND METHODS: We used duplex ultrasound to study the arteries in the neck including the common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA) and the vertebral arteries. For the intracranial arteries, transcranial Doppler ultrasound was used to study the blood flow velocities and directions in the middle cerebral artery (MCA), anterior cerebral artery (ACA), posterior cerebral artery (PCA), ophthalmic artery, basilar and vertebral arteries. The ultrasonographic findings were compared with magnetic resonance angiography (MRA) and standard angiography. RESULTS: Four patients with the diagnosis of Takayasu arteritis were studied. One patient presented with ischemic optic neuropathy and was found to have absent radial pulse. Two patients presented with severe hypertension in young age. The other patient had accidental findings of unmeasurable blood pressure in both arms. One patient had abnormal carotid duplex ultrasound. He was found to have an occlusion of the right ICA. Thickening of the wall of the left ICA was also noted. Reduction of flow velocity in the MCA was demonstrated on TCD. There was evidence of collateral circulation from the contralateral carotid artery demonstrated by reversal of flow in the ipsilateral A1 segment of the ACA. MRA and angiography confirmed the ultrasound findings. Three patients had normal carotid duplex ultrasound but one of them was found to have a severe stenosis at the origin of the common carotid artery by MRA and angiogram. Absence of one vertebral artery was noted in three patients. MRA and angiogram confirmed the occlusion of the same vertebral arteries at their origins. In one patient, reversal of flow in the intracranial part (V4 segment) of the affected vertebral artery indicating collateral flow from contralateral vertebral and basilar arteries was demonstrated. CONCLUSION: Ultrasonography could be used as an additional noninvasive procedure apart from CT angiography, MRI and MRA in patients with Takayasu arteritis. Occlusion and wall thickening of the neck artery could be detected by color coded B-mode and Doppler ultrasound. Transcranial Doppler was useful in evaluation of flow velocity and flow direction of the arteries around the circle of Willis. PMID- 9951817 TI - Magnetic resonance imaging diagnosis of Takayasu arteritis. AB - Conventional angiography has been used for diagnosis of Takayasu arteritis (TA). In early stage of TA, subtle inflammatory wall thickening of the aorta and its branches without significant stenosis may be the only morphologic change of TA. Magnetic resonance (MR) imaging appears to be useful in the diagnosis of early stage TA by visualizing concentric wall thickening of the vessels. T2-weighted images may show bright signal of edema in and around the inflamed vessel. Contrast media-enhanced MR shows enhanced wall of vessels even in chronic stage, which may indicate the activity of TA at the tissue level. MR angiography allows us noninvasive assessment of the vascular tree and it may replace conventional angiography. PMID- 9951818 TI - Antiaorta antibodies and Takayasu arteritis. AB - A search for antibodies reactive against a total human aorta extract and its main protein components such as elastin, fibronectin and collagen was attempted by electroimmunetransference and ELISA. Thirty five sera from clinically and angiographically proven diagnosis of Takayasu Arteritis patients were compared with 32 sera from people without abnormalities. Non specific binding was found on electroimmune transference and no difference was shown in optical density readings in ELISA, therefore, we did not demonstrate the presence of antiaorta specific antibodies in this vasculitic condition. Our findings are in agreement with several authors, the contribution of humoral immunity to pathogenesis of Takayasu Arteritis has not been proved yet. PMID- 9951819 TI - Surrogate markers of disease activity in patients with Takayasu arteritis. A preliminary report from The International Network for the Study of the Systemic Vasculitides (INSSYS). AB - Twenty-nine patients with clinically defined Takayasu arteritis and 26 healthy control volunteers were recruited by INSSYS investigators from their clinical practices. Patients with Takayasu arteritis were divided into those with clear cut clinically active or inactive disease based on Birmingham Vasculitis Activity Scores. Multiple serological tests were performed including ESR, C-reactive protein, tissue factor, von Willebrand factor, thrombomodulin, tissue plasminogen activator, ICAM-1, VCAM-1, E-selectin and PECAM-1. No test was reliably able to distinguish between healthy volunteers and patients with active Takayasu arteritis. At present there is no known serological test which can consistently supplant vascular histopathology in determining the activity of Takayasu arteritis. PMID- 9951820 TI - Surgical treatment for annuloaortic ectasia in Takayasu arteritis. AB - Annuloaortic ectasia (AAE) associated with aortic regurgitation (AR) is a rare involvement in Takayasu arteritis. There are many difficult problems in surgical treatment of this lesion because of its inflammatory nature. We developed a composite graft repair technique to avoid complications associated with Bentall type procedures for treatment of AAE+AR. The technique consists of a double proximal suturing and direct coronary artery reimplantation as a Carrel patch without wrapping. Eight patients (one male, seven females) received this composite graft repair for treatment of AAE+AR due to Takayasu arteritis. Of them, two patients were in active phase. There was one hospital death probably due to ventricular arrhythmia, however, no late death occurred. And there were no late complications related to operative procedures. Thus, our composite graft repair technique for treatment of AAE+AR in Takayasu arteritis can prevent major complications associated with Bentall type procedures. However, close serial follow-up, careful control of inflammation, and early detection and treatment of other vascular involvements are necessary in the postoperative management of patients with Takayasu arteritis. PMID- 9951821 TI - Percutaneous transluminal renal angioplasty in aortoarteritis. AB - Percutaneous transluminal renal angioplasty (PTRA) was performed in 26 patients with aortoarteritis, including unilateral renal artery stenosis in ten patients, bilateral renal artery stenosis in 16 patients. The total of 37 stenotic artery were performed by PTRA. Among them, 30 stenosis (81.1 per cent) were technically successful, three stenosis (8.1 per cent) were technically improved, and four stenosis were resistant to dilatation. The blood pressure responses were observed after PTRA, including cured in 17 patients (65.4 per cent), improved in five patients (19.2 per cent), failed in four patients (15.4 per cent). Sixteen patients after successful angioplasty were followed-up from 6 months to 15 years (average 5.4 years). The blood pressure was still normal in 12 patients (75 per cent). The blood pressure gradually increased may be due to restenosis in four patients (25 per cent). PMID- 9951822 TI - Stent supported angioplasty in Takayasu arteritis. AB - Eleven patients with Takayasu Arteritis (TA) underwent angioplasty and stent placement in aorta, renal, carotid, subclavian and coronary arteries. Five wall stents were deployed in aorta in four patients. Indications for angioplasty and stent placement in aorta included hypertension in four patients and claudication and erectile impotence in one patient each. Post-procedure the peak systolic pressure gradient across the stenotic segment in the aorta disappeared. Six patients underwent angioplasty and stent placement in carotid arteries. Indications were syncope in 6 patients, loss of vision, stroke, transient ischaemic attack and seizures in one patients each. There was a marked improvement in symptoms in the patients following the procedure. For chronic total occlusion of subclavian arteries, two stents were deployed in two patients. Following the stent placement pulses in upper limb reappeared. Stents were also deployed to treat near total occlusion of right coronary artery and flow limited dissection of renal artery in one patient each. Complications of the procedure included pain in the back, mild hypertension, transient bradycardia and conduction block in one patient each. In conclusion, the stenotic and obliterative vascular lesions in TA can be managed successfully with angioplasty and stent placement. A long term follow up is required to determine the re stenosis rate. PMID- 9951823 TI - Atypical Takayasu arteritis: late onset and arthritic manifestations: report of two cases. AB - We recently experienced two cases of Takayasu arteritis rendered atypical by late onset (over 60 years of age) of disease, involvement of distal branch arteries, and association with rheumatoid arthritis. In both cases, roentgenologic examination revealed typical appearance of the abdominal aorta and stenosis of the subclavian artery entirely compatible with Takayasu arteritis. In addition, Case 1 had occlusive lesions of the superficial femoral arteries and Case 2 manifested occlusion of the axillary artery. Laboratory findings showed increased ESR and CRP but negative HLA B52 locus. Both cases showed arthritis symptoms with swelling, pain, and tenderness in joints. Case 1 did not manifest erosive lesions and positive RA test; Case 2 showed roentgenologic erosive lesions in hand joints with positive RA test. A surgical specimen from the femoral artery of Case 1 showed lesions suggesting Takayasu arteritis. Based upon these findings, we diagnosed the two patients as having atypical Takayasu arteritis with late middle age onset and arthritic manifestations. PMID- 9951824 TI - Subclavian steal syndrome secondary to Takayasu arteritis. AB - We present a case of 'subclavian steal syndrome' secondary to Takayasu arteritis, in a 32-year-old, Japanese woman, whose clinical manifestations result from severe ocular and brain ischemia, refractory to high dose systemic corticosteroids. Surgical management using two bypass-grafts was carried out. The first one, a GoreTex, 8 mm in diameter, thin wall, stretch type with ring-bypass graft, from the left external iliac artery to the ipsilateral axillary artery. The second one, an autologous reverse saphenous vein graft from the left subclavian artery to the ipsilateral common carotid artery. The result was a remarkable improvement of the patient's general condition and symptoms. Patency of the extra-anatomic conduits was established by digital subtraction angiography (DSA), and transcranial Doppler evaluation, as well as flow velocity assessment revealed an objective improvement of the blood supply to the ischemic areas. The present surgical approach was justified since the inflammatory process extended to the aortic arch. The development of new and efficient operatory techniques, and continuous improvement of the graft-materials provide better expectations for the long-term outcome of refractory syndromes. PMID- 9951825 TI - Pathology and pathogenesis of Buerger's disease. AB - Since Buerger's disease, which is also called 'thromboangiitis obliterans', was proposed in 1908 (Buerger, Am J Med Soc 1908;136:567), more cases have been reported from the United States, Europe, and especially from the Orient. However the pathogenesis of this disease remains unclarified, and its acceptance as a specific disease entity has been disputed (Gore and Burrows, Am J Clin Pathol 1958;29:319; Wessler et al., N Engl J Med 1960;262:1149). We histologically examined the surgically resected arterial specimens from 113 cases, 109 males and four females, clinically diagnosed as Buerger's disease in 1975-1976 and reported the results in 1978 (Kurozumi and Tanaka, Vasc Surg 1978;12:63) and proposed that the term 'Buerger's disease' should be replaced by 'Buerger's syndrome'. We reexamined the above-mentioned cases and will report the pathology and propose the possible pathogenesis of Buerger's disease. PMID- 9951826 TI - Diagnostic criteria of Buerger's disease. AB - After many changes, Buerger's disease stands as an independent clinicopathologic entity, but a better understanding of Buerger's disease has been impeded by the lack of unanimous diagnostic criteria of the disease. Since specificity of Buerger's disease is characterized by peripheral ischemia of an inflammatory nature and with a self-limiting course, diagnostic criteria of Buerger's disease should be discussed from clinical point of view. Our clinical criteria for the diagnosis of Buerger's disease are: (1) smoking history; (2) onset before the age of 50 years; (3) infrapopliteal arterial occlusions; (4) either upper limb involvement or phlebitis migrans; and (5) absence of atherosclerotic risk factors other than smoking. Confident clinical diagnosis of Buerger's disease may be made only when all five requirements have been fulfilled. A set of strict and well defined clinical diagnostic criteria is essential for any study of Buerger's disease to ensure the homogeneity of the selected patient population for valid comparisons. PMID- 9951827 TI - Visceral intestinal Buerger's disease. AB - Buerger's disease is a non-arteriosclerotic, segmental, progressive, inflammatory vaso-occlusive disease of unknown etiology. Buerger's disease occurs almost exclusively in susceptible young men who are habitual tobacco users; usually with onset of symptoms before the age of 40 years. Buerger's disease affects both arteries and veins of principally lower and upper limbs and, rarely, of the viscera. To date, only 16 confirmed cases of visceral-intestinal Buerger's disease have been reported in the English-language literature; and all 16 patients were men. We describe here, for the first time, two young women with intestinal Buerger's disease who died of complications of ischemic bowel disease. PMID- 9951828 TI - Buerger's disease with intestinal involvement. AB - Here I describe three cases of intestinal Buerger's disease and review previously reported cases. All patients had involvement of the extremities and clinical manifestations of Buerger's disease. Occlusive changes in intestinal arteries also occurred, in both the presence and absence of abdominal symptoms. Intestinal Buerger's disease may be asymptomatic, acute, or chronic, and treatment varies according to the type of disease. PMID- 9951829 TI - Buerger's disease at the 'San Juan De Dios' Hospital, Santa Fe De Bogota, Colombia. AB - OBJECTIVES: To know the clinical characteristics in the presentation of Buerger's disease in San Juan de Dios Hospital, Bogota, Colombia, between 1986 and 1996, and compare them with a previous series from the same Hospital and another reported in international literature; To determine the changes in the form of appearance of the disease. METHODS: We reviewed the clinical information of 22 patients with diagnosis of Buerger's disease, observed between 1986 and 1993, and we added the information of the clinical histories of eight other patients with equal diagnosis, observed between 1994 and 1996 in our Unit. RESULTS: We observed 30 patients: 28 men (93%) and two women (7%), with a ratio M:F of 14:1, with an average age of 39+10 years (range from 18 to 52 years). Sixty percent were younger than 40 years and only the 10% were older than 50 years. The most frequent reasons for consultation were: pain in rest in the affected extremity, gangrene and ulceration in more than 50%. Raynaud's phenomenon in 30%, and the related surgical history in 40%. The pedal pulse was the most compromised followed by popliteal, poster or tibial and femoral. We did not observe the presence of thrombophlebitis. Eighty percent showed compromise of more than one extremity. All of them were active smokers. Three patients showed IgG anticardiolipine antibodies at high level. CONCLUSIONS: The clinical characteristics are similar to those reported, we find also a reduction of the disease diagnosis. It calls to our attention that no thrombophlebitis was found in the present series and the less compromise of the upper extremities with a frequent femoral compromise. All this points toward a change in the natural history of the disease. PMID- 9951830 TI - The change in concept and surgical treatment on Buerger's disease--personal experience and review. AB - Buerger's disease was originally described by Leo Buerger in 1908 as thromboangitis obliterance and has been considered as one of the most intractable vasculitis syndromes in our country. This lesion is popularly seen in male young generation with a background history of heavy smoking. Buerger's disease in Japan has been frequently seen in our practice; however, it is noted that there have been certain definitive changes in relation to number of patients, clinical manifestation as well as course of treatment in particular in surgical treatment. Firstly, the number of patients who visited at outpatient clinic as well as to admit hospital has been sharply declined. Secondly, the number of surgical treatments of Buerger's disease have also decreased. The sympathectomy, mainly lumbal sympathectomy, which was maintained at about 15 to 20% of the number of patients admitted, was virtually abolished from the practice and mainly converted to the medical and pharmacological treatment by prostaglandin. The reliability of pharmacological sympathectomy is one of the other reasons which contributed to the shift of treatment. It is also our impression that the severity of the disease itself has been changed, in other words, we do not frequently see very severely ill patients. As far as surgery is concerned the important modality in the treatment for the advanced lesion of Buerger's disease is mainly confined in small arteries with multisegmental occlusion. As a consequence, the surgical reconstructive procedures are technically difficult and long term patency rate is considered to be low. As far as our experience is concerned, it is noted that the number of bypass surgery was most frequently seen at below trifurcation segment of knee joint; in other words, peripheral, distal type bypass was the most popular, followed by above knee segment. The reconstructive surgery at femoral region was least frequently seen. On the other hand, the patency rate of bypass graft was higher in the proximal segment in comparison to the distal segment. Although the number of arterial reconstructive procedures has been definitively declined, as was seen in sympathectomy surgery. It is difficult to predict accurately what kind of factors are affecting or contributing to the change in concept in Buerger's disease as well as the course of treatment, it is suggested that the environmental factors may playing a major role for the modification of disease process. PMID- 9951831 TI - Immunogenetic analysis of Buerger's disease in India. AB - In order to understand the role of HLA linked factors in determining susceptibility to Buerger's disease, we have studied 21 unrelated Asian Indian patients belonging to the North Indian states of Punjab, Haryana, Uttar Pradesh and Delhi, representing mainly a lower socioeconomic background. The data was compared with healthy controls belonging to the same ethnic group. The study revealed an over representation of HLA-B40 (60+61) (chi2=6.12; P<0.02) and DR2 (chi2=10.2; P<0.002). Amongst the patients no particular association or linkage disequilibrium with any of the five alleles of the MIC-A gene could be derived in the small sample size studied. PMID- 9951832 TI - Takayasu arteritis and Buerger disease III. The International Conference on Takayasu arteritis and Buerger disease. 4-6 November, 1997. General discussion. PMID- 9951834 TI - Distribution of interstitial telomere-related sequences in the human genome and their relationship with fragile sites. AB - Using a computer search in the mapped human genome, we could show that interstitial telomere-related sequences are clustered in R-bands, and, in some cases, coexist with mapped fragile sites. We speculate that this association could predispose to chromosome fragility and recombination. PMID- 9951833 TI - Effects of ultraviolet C radiation on cellular proliferation in p53-/- keratinocytes. AB - Skin cancer is the most common tumor type in Caucasians, with an incidence that approaches the lifetime risk for all other cancer subtypes combined. The most common predisposing factor is exposure to ultraviolet (UV) radiation present in sunlight. The purpose of this investigation was to evaluate the effects of UVC on the proliferation of a p53-/- human keratinocyte cell line, HaCaT, and how UVC alters the response of these cells to transforming growth factors (TGF)-alpha and TGF-beta1. UVC treatment during G0/G1 phase resulted in decreased incorporation of [3H]thymidine, an effect that was enhanced by pretreatment with TGF-beta1. However, irradiation of HaCaT cells in S or G2/M phase had no effect on the incorporation of [3H]thymidine, suggesting that these cells failed to undergo G2/M arrest in response to UV-mediated DNA damage. UVC had no effect on TGF-beta1 mediated growth inhibition, but decreased the mitogenic response of HaCaT cells to TGF-alpha. Seven days after irradiation, there were no differences between the number of cells that were exposed to UVC and those that were not, suggesting that the effects of UVC on proliferation of HaCaT cells was transient. These results suggested that UVC did not stimulate proliferation of p53-/- HaCaT cells, or cause cell cycle arrest in G2/M, which would allow transmission of chromosomal damage to daughter cells during M phase. Failure of the G2/M cell cycle checkpoint may be one of the mechanisms by which p53 results in genomic instability. PMID- 9951835 TI - Telomerase activity in radiation-induced chronic human skin ulcers. AB - An increasing activity of telomerase is considered to be a reliable molecular biological marker for malignancy. There is much research work on telomerase detection in malignant tumors, but no such investigation was carried out in chronic skin ulcers induced by radiation. We investigated the levels of telomerase activity in radiation-induced chronic human skin ulcers and the possible relationship between the enzyme and cancer transformation. We used the nonisotopic telomere repeat amplification protocol (TRAP) in 20 cases of chronic human skin ulcers induced by radiation, 5 cases of normal skin, 2 of burned skin, and 5 of carcinoma. Our results showed that the positive rate for telomerase activity was 30% in chronic radiation skin ulcers, 0% in normal and burned skin, and 100% in carcinoma. The telomerase activity in radiation ulcers was weaker than that detected in carcinoma. We suggest that the telomerase activity assay could be used as a marker for predicting the prognosis and the effect of treatment in chronic human skin ulcers induced by radiation. PMID- 9951836 TI - Induction of micronuclei in human lymphocytes by organic solvents in vitro. AB - Our work is focused on identifying micronuclei (MN) induced in whole blood lymphocyte cultures after treatment with the organic solvents toluene, benzene, and acetone. We used the micronucleus test as a cytogenetic biomarker for genotoxicity and treated whole blood cultures with different concentrations of these solvents (0.1 to 5 mM) and mixtures of them (toluene plus acetone, toluene plus benzene). Our results did not show a significant increase in the number of micronuclei in binucleated lymphocytes after 48 hr of in vitro treatment. The addition of an external metabolic factor (10% S9 mix for 2 hr) in blood cultures treated with the organic solvents or their mixtures did not cause induction of MN. These results indicate the lack of genotoxic activity of toluene, benzene, and acetone in vitro. PMID- 9951838 TI - The distribution of selenium levels in Saudi dairy farms: a preliminary report from Al-Kharj. AB - A survey was undertaken within four dairy farms in Al-Kharj area, Saudi Arabia, to measure the selenium (Se) content in the soil, alfalfa, and water samples. Selenium was determined by Inductively Coupled Plasma Atomic Emission Spectrometry. Selenium content in the studied soil samples was low, and, in some farms, the Se content of alfalfa approached that in the low-Se zone in China. This may be reflected in the dietary Se-intake level of the Saudi population with an increased risk for developing Se deficiency-associated diseases. We suggest that extensive surveys of the Se status should be carried out in Saudi Arabia. Moreover, Se supplementation of the soil may be advisable. PMID- 9951837 TI - The effects of cadmium on the hepatic and renal levels of reduced glutathione, the activity of glutathione S-transferase and gamma glutamyl transpeptidase. AB - Cadmium chloride, injected subcutaneously in mice at doses of 1.0, 1.5, and 2.0 mg/Kg body weight, resulted in the alteration of body weight and relative liver and kidney weights, the hepatic and renal reduced glutathione levels, and the activity of the enzymes glutathione S-transferase and gamma-glutamyl transpeptidase in a dose-dependent manner. Body weight increased insignificantly with dosage, but significant elevations in relative liver weight (29% of control) and particularly in kidney weight (93% of control) were documented in the cases that received the highest dose of cadmium chloride (2.0 mg/Kg body weight). The treatment significantly lowered hepatic and renal reduced glutathione levels and glutathione S-transferase activity. On the other hand, the gamma-glutamyl transpeptidase activity was found to increase significantly after treatment, with the highest values in the liver (137% of control) and in the kidneys (204% of control). We found that cadmium chloride at 2.0 mg/Km body weight produced the greatest changes in the abovementioned parameters. A significant correlation (r) was observed in some cases among the abovementioned biomolecules between, as well as within, the organs. The present study showed that the effects of cadmium could be correlated with a decreased level of reduced glutathione and glutathione S transferase activity and an increased activity of gamma-glutamyl transpeptidase in liver and kidney. PMID- 9951840 TI - Diagnosis of mucosa-associated lymphoid tissue (MALT) lymphoma in gastroendoscopic biopsy specimens. AB - We evaluated the diagnostic criteria of gastric lymphoma in endoscopic biopsies. METHODS: Our study included cases diagnosed as lymphoma by gastroendoscopic biopsy between 1984 and 1994 that were available in the files of the Department of Gastroenterology, Chinese PLA General Hospital. RESULTS: Among 53,400 cases of gastroendoscopy, we found 1672 (3%) cases of malignant neoplasm that were diagnosed by endoscopic features and histological findings. Thirty-eight cases of primary gastric lymphoma included 22 men and 16 women 16 to 82 years old, with a median age of 47.7. The endoscopy showed the ulcerative type in 12 cases, diffuse infiltrating type in 11 cases, massive infiltrating type in 6 cases, and large mucosal folds type in 4 cases. Five cases had a mixed type pattern of involvement. Histologically, 34 cases showed mucosa-associated lymphoid tissue lymphoma (89.5%), 2 cases had lymphoblastic lymphoma, and 2 cases were unclassifiable because of crush artifact of neoplastic cells. The majority of cases of primary gastric lymphoma have morphologic and clinical features that justify their inclusion in the category of low-grade lymphoma of mucosa associated lymphoid tissue (MALT). PMID- 9951839 TI - Passive dosimetry as an alternative technique to dynamic enrichment of organic pollutants of indoor air. AB - Evaluation of the quality of indoor air was carried out in 20 apartments, 3 offices, and 3 laboratories in the Tricity area in Poland with reference to concentrations of selected volatile organic compounds (VOCs), such as benzene, toluene, butyl acetate, ethylbenzene, m-xylene, styrene, and m-dichlorobenzene. The time dependence of concentrations of selected VOCs in a newly erected building was studied. Two different techniques were used for the isolation and preconcentration of analytes from air samples: a passive method employing a home made permeation-type passive sampler and a dynamic method based on a sorption tube. In both cases, activated charcoal was used as a sorption medium (trap packing). The sorption tube was used to validate the results obtained by the passive method, as well. In the majority of dwellings examined, the concentrations of air pollutants were relatively low and did not exceed the MAC values. No significant differences were observed between MAC concentrations determined by using the passive or the dynamic method of air sampling. The results obtained by both sampling methods were characterized by similar precision. PMID- 9951841 TI - Histopathological changes in hepatocellular carcinoma after hepatic arterial embolization. AB - Hepatic arterial embolization (HAE) is used to treat hepatocellular carcinoma (HCC), but little is known about the histopathological changes occurring after HAE. Thirty-nine cases of liver neoplasms treated with HAE and 11 cases of liver neoplasms after digital selective angiography (DSA) were analyzed histopathologically. The pathological type, histological grade, degree of necrosis, capsular changes, number of HAE, vessel injury, and lymphocytic infiltration were recorded. Six cases showed 100% necrosis, 14 cases had 30 to 95% necrosis, and 19 cases 0 to 5% necrosis after HAE. Eleven cases of DSA did not reveal histological features of necrosis. The necrosis was related to the pathological type of tumor, encapsulation, and degree of vascular injury and was independent of histological grade, number of HAE, or lymphocytic infiltration of the neoplasm. HAE is an effective therapy for advanced stage of HCC. The encapsulated HCC is a preferred indicator for HAE. PMID- 9951843 TI - Effect of malathion, an organophosphorus pesticide, on the serum proteins of Heteropneustes fossilis (BLOCH). AB - The use of pesticides to control pests and to increase food production is a normal process in this modern age. The objective of this study was to determine changes in different serum protein fractions caused by the action of malathion, a commonly used pesticide. We used Indian catfish, Heteropneustes fossilis. The fish were exposed to a sublethal dose of 4 mg/L of malathion for 24, 48, 72, and 96 hr. The LC50 value at 96 hr was found to be 11.676 mg/L. The results showed the formation of three low and four high mobility fractions and the disappearance of some protein fractions at different periods of exposure. The appearance of fractions A, B, and C (low-mobility proteins) may be due to altered immune responses caused by cellular damage. The appearance of new high-mobility fractions (D, E, F, and G) is possibly due to the breakdown of red blood cells and other cellular components. The findings of this study indicate that the high concentration of malathion (4 mg/L) induced more alterations in serum proteins compared with the low concentration (1.2 mg/L) used in our previous study. PMID- 9951842 TI - Effect of cocaine on testicular blood flow in rats: evaluation by percutaneous injection of xenon-133. AB - PURPOSE: Cocaine abuse has reached epidemic proportions in the United States. Our recent study has shown that cocaine has adverse action on spermatogenesis and fertility in male rats. The indirect action of cocaine occurs by blocking the reuptake of neurotransmitter, which causes local vasoconstriction. In this study we evaluate blood flow to the testes after subcutaneous injection of cocaine to male rats. METHODS: Male Sprague-Dawley rats were divided into two main groups. The treatment group received subcutaneous cocaine (30 mg/kg body weight) and the control animals received normal saline. Xenon-133 wash out experiments were carried out on testes at 5, 10, 15, 20, 30, 45, 60, 90 min and 4.5 hours after injection of cocaine or normal saline. Statistical analysis was done by SPSS V. 7.S for windows. P < 0.05 was considered statistically significant. RESULTS: There was a reduction in testicular blood flow after cocaine administration to male rats. This vasoconstrictor effect was most pronounced at 15 min after injection of cocaine and persisted up to 60 min. At 90 min, the early restitution of blood flow to ischemic tissue occurred. There was a significant increase in testicular blood flow in cocaine-treated groups than in the control group during restitution phases at 90 min. At 4.5 hours, there was no difference in blood flow in both groups. CONCLUSION: This study demonstrates that cocaine, when given subcutaneously at a 30 mg/kg body weight dose, results in prolonged vasoconstriction of the blood vessels to the testes. Adverse effects of cocaine on the testes may be in part due to ischemic and postischemic reperfusion injury to the organ. PMID- 9951844 TI - Clinical trials of HCC in Taiwan. AB - Tumors of the liver represent one of the most common malignancies in the world. Little has changed in the past 5 years to alter the statistics. Published census from the Department of Health in Taiwan, 1993, showed that cancer death was 107/100,000 population. Hepatoma is the number one cause of cancer death with 24.05/100,000 population. It increased 11.23% in comparison with last year's survey. About 5,000 people die from hepatoma each year in Taiwan. Both case control studies and cohort studies have shown a strong association between chronic hepatitis B carriage rate and an increased incidence of hepatocellular carcinoma (HCC). Although up to a 200-fold excess incidence of HCC was found in Taiwan, the association of chronic hepatitis B virus in different populations of Southeast Asia who have HCC is somewhat varied. Many treatment modalities for hepatoma have been attempted. Chemotherapy is usually given to patients with metastatic disease or for persistent or recurrent disease. The consensus is that no single drug or combination of drugs given systemically leads to a reproducible response rate of more than 25% or has any effect on survival, or survival beyond that of untreated control. The identification of new, effective chemotherapy drugs and other modality treatments for advanced stage HCC is urgently required. We report here the results regarding response rates, toxicities, and survivals of 14 on-going and finished Phase I, II and III clinical trials on hepatoma. These include chemotherapy and/or biological modifier, radioisotope, hormone, and hepatic infusion. Nine future therapies and gene therapies will also be discussed. PMID- 9951845 TI - Liver transplantation for hepatocellular carcinoma? AB - The worldwide experience of the largest transplant programs with hepatic resection and liver transplantation for primary hepatic cancer are reviewed. The pros and cons for resection as well as for transplantation are presented. The choice between resection or transplantation may depend upon the geographic location of the individual patient, their financial resources, the availability of specific surgical expertise, as well as a panoply of medical/surgical factors that define what can or cannot be accomplished. In the absence of limiting factors, transplantation appears to be the surgical method of choice for small neoplastic lesions less than 5 cm in diameter, particularly when the number of lesions is small (< or = 3) and the cancer occurs in the setting of cirrhosis. Surgical resection is the preferred procedure for larger lesions and for those occurring in individuals without confounding cirrhosis. PMID- 9951846 TI - Pre-operative chemoembolization of hepatocellular carcinoma in cirrhotic patients. AB - BACKGROUND/AIMS: The aim of the study was to evaluate clinical and pathological effects of transcatheter arterial chemoembolization (TACE) before surgical resection for hepatocellular carcinoma (HCC) in cirrhosis (55 patients); results were compared with a group of 45 patients undergoing surgical resection without TACE. METHODOLOGY: From March 1989 to December 1997, 55 cirrhotic patients, affected by surgically resectable HCC not larger than 5 cm with unifocal or bifocal tumor lesions, underwent TACE pre-operatively. RESULTS: Massive necrosis was observed in 26%, necrosis > 50% in 38% of lesions. Neoplastic cells were found in 47% of cases within the capsule or in the pericapsular tissue. Satellite nodules showed a low rate of necrosis. Mortality and morbidity in the pre operative TACE group were 1.8% and 29%, respectively, and 4.4% and 33%, respectively, in the control group. One-, 3- and 5-year patient survival rates were 87%, 70% and 39%, respectively, versus 79%, 38% and 19%, respectively (p<0.02), in the control group. Disease-free survival was 40% and 28% at 3 years and 5 years with pre-operative TACE versus 20% and 11% (p<0.05). CONCLUSIONS: Pre operative TACE can be performed with low morbidity. TACE can necrotize the main lesion and temporarily arrest portal diffusion of neoplastic cells by acting on microvascular infiltration. No evident effect on satellites and pericapsular neoplastic foci was observed. The long-term patients and disease-free survival rates were improved upon. PMID- 9951847 TI - Biochemical modulation of doxorubicin by high-dose tamoxifen in the treatment of advanced hepatocellular carcinoma. AB - BACKGROUND/AIMS: In vitro data have indicated that tamoxifen (> 2.5 uM) significantly enhances the cytotoxic effect of doxorubicin in hepatocellular carcinoma (HCC) cells. This clinical study was conducted to examine whether tamoxifen, at a dose sufficient to result in a plasma concentration of more than 2.5 uM, may improve the therapeutic efficacy of doxorubicin in patients with advanced HCC. METHODOLOGY: A prospective phase II study was conducted. Eligible patients had unresectable and non-embolizable HCC, objectively measurable tumors, adequate neogram with absolute granulocyte count > 2,000/mm3 and platelet count > 1 x 10/mm3, total serum bilirubin < 3.0 mg/dl, age > or = 75 year, and a Karnofsky performance status < or = 50%. The treatment included oral tamoxifen 40 mg/m2, q.i.d, Day 1 to 7, and intravenous doxorubicin 60 mg/m2, Day 4, repeated every 3 weeks. RESULTS: Between May 1994 and December 1996, a total of 38 patients were enrolled in the study. Thirty-six patients were evaluable for tumor response and treatment-related toxicities. There were 32 men and 4 women, with a median age of 49 years. They received an average of 3.8 (range:1-12) courses of chemotherapy. ECOG (Eastern Cooperative Oncology Group) Grade 3-4 leucopenia and Grade 3-4 thrombocytopenia developed in 27.2% and 12.5% courses given, respectively. Gastrointestinal toxicity was generally mild. Three patients developed symptomatic cardiac toxicity. Twelve patients (33.3%, 95% confidence interval 17-51%) had achieved a partial remission (PR), with a median progression free survival of 7 months. Median survivals of the responders and non-responders were 10 and 3 months, respectively (p<0.05). The median Karnofsky performance status of the responders improved from 74.0+/-6.3% to a post-chemotherapy value of 93.2+/-4.6% (p<0.05) CONCLUSIONS: High dose tamoxifen appears to be an effective biochemical modulator of doxorubicin in the treatment of HCC. Prospective randomized phase III studies comparing doxorubicin alone versus doxorubicin plus high-dose tamoxifen are needed. PMID- 9951848 TI - Efficacy of repeated percutaneous isolated liver chemoperfusion in local control of unresectable hepatocellular carcinoma. AB - BACKGROUND/AIMS: Percutaneous isolated liver chemoperfusion (PILP) with hepatic venous isolation and charcoal hemoperfusion (HVI-CHP) enables high-dose intraarterial infusion of cytotoxic agents while reducing systemic toxicity. We report here the effect of repeated PILP with HVI-CHP on local control of unresectable hepatocellular carcinoma (HCC). METHODOLOGY: After placement of a hepatic arterial infusion (HAI) catheter, a 4-lumen-2-balloon catheter (24F) was introduced into the retrohepatic inferior vena cava through the femoral vein, and the balloons were inflated to accomplish HVI. During HAI of adriamycin (60-150 mg/m2), total hepatic venous outflow was captured via fenestrations of one major lumen between the balloons and pumped out into CHP filters. The filtered blood was returned to the right atrium through the end opening of another major lumen of the catheter. Of 30 patients, 8 had repeated PILP in a range of 2-4 treatments, and 22 had a single treatment. RESULTS: Eleven (52%) of 21 evaluable patients in the single PILP group and 7 out of 8 patients (88%) in the repeated PILP group had partial or complete response. Median durations of response in responding patients were 6 and 21 months in the single and the repeated PILP groups, respectively (p=0.02). The 1- and 2-year survival rates (single vs. repeated) were 57% vs 88%, and 29% vs 70%, respectively (p=0.05). CONCLUSIONS: Repeated PILP could be performed safely in patients with advanced HCC and significantly prolonged the duration of remission in patients with unresectable HCC. PMID- 9951849 TI - An introduction to mucin-producing tumors of the pancreas: why they deserve more attention. AB - BACKGROUND/AIMS: Mucin-producing tumors of the pancreas are clinically characterized by dilatation of the major pancreatic duct due to pooled mucin, and by dilatation of the orifice of the duodenal papilla. The concept of mucin producing tumors of the pancreas was proposed in 1982, but has undergone revision since then. METHODOLOGY: The present paper reviews the history, classification, and description of mucin-producing tumors of the pancreas. Problems relating to this type of tumor are also discussed. RESULTS: The clinical concept of mucin producing tumors of the pancreas has affected studies of the pancreatic diseases in many areas. First, when recognition of pancreatic cancer with a relatively good prognosis commenced, this concept led to awareness of the necessity for a detailed examination of the pancreatic duct epitheliums in cases of suspected pancreatic carcinoma. Second, the concept made it easier to diagnose carcinoma in situ. Third, new classifications of cystic lesions of the pancreas were initiated. Fourth, a molecular biological view of the onset of pancreatic cancer was developed. Pathologically, this type of tumor is characterized by papillary growth of the epitheliums within the pancreatic duct, and it has been regarded as having a good prognosis. The term mucin-producing tumors of the pancreas now includes: intraductal papillary tumors which are non-invasive carcinomas or carcinoma in situ; duct-ectatic tumors, or mucinous cystic tumors; and, invasive carcinomas, derived from the former types. CONCLUSIONS: The definition of "mucin producing tumor of the pancreas" has been undergoing revision. In the past, it has referred to pancreatic tumors with a good prognosis. It is now time to consider a more detailed classification. PMID- 9951850 TI - Observations on the etiology and pathogenesis of intraductal papillary-mucinous neoplasms of the pancreas. AB - During the last two decades, intraductal papillary-mucinous neoplasms have been recognised as a group that should be distinguished from ductal adenocarcinomas. The literature for these tumors is confusing with the use of many different terms such as mucinous duct ectasia and, sometimes, there is a failure to distinguish them from mucinous cystic tumors. The recognition and apparently increasing incidence of these neoplasms is perhaps entirely attributable to improved diagnostic and imaging methods such as endoscopic retrograde pancreatography and computerized tomography. Experimental, molecular, and epidemiologic data suggest that the etiology of IPMN overlaps that of solid ductal adenocarcinomas. PMID- 9951851 TI - Clinicopathologic view of intraductal papillary-mucinous tumor of the pancreas. AB - Intraductal papillary-mucinous tumors (IPMTs) of the pancreas form a special group of neoplasms characterized by intraductal papillary growth of mucin producing columnar cells. Included among these neoplasms are papillary and villous adenomas, lesions with mucinous duct ectasia and mucin-producing carcinomas. Most patients are males and present with episodic pancreatitis-like symptoms, which may have been noted for years. These symptoms are due to incomplete and later complete duct obstruction by papillary proliferations and/or mucin, which eventually cause fibrotic atrophy of the normal parenchyma. At the time of diagnosis, malignant non-invasive IPMTs are observed in 5-30% of the cases. Fifteen to forty percent of the IPMTs show invasion and half of the invasive IPMTs have metastases. Pre-operatively, invasiveness cannot be predicted. Patients with non-invasive IPMT survive for long periods after surgery, as do many patients with invasive, non-metastatic IPMT, although intraductal proliferation with a mild degree of atypia may be present at the resection margin. In patients with invasive and metastatic IPMT, survival ranges from a few months up to 3 years. PMID- 9951852 TI - Diagnosis of mucin-producing tumor of the pancreas by balloon-catheter endoscopic retrograde pancreatography--compression study. AB - The procedure of choice for the treatment of mucin-producing pancreatic tumor (MPPT) remains controversial, since it includes not only malignant but also benign lesions. The purpose of the present study was to characterize 53 consecutive cases of MPPT and to elucidate the characteristics of benign or malignant MPPT according to the findings of an improved method of endoscopic retrograde pancreatography (ERP), namely balloon-catheter ERP-compression study (balloon ERP-CS), as well as endoscopic ultrasonography (EUS), in comparison with a histological examination. There were 37 male and 16 female cases with a median age of 63+/-11 (mean+/-SD). The balloon ERP-CS was performed in all cases, and the obtained pancreatograms were classified into two types: Main Duct type and Branch Duct type. The latter was further divided into subtypes A and B. The Branch Duct A type showed only cystic dilatation of the branch duct. If the main pancreatic duct downstream to a cyst showed more than a 5 mm dilatation, this was classified as a Branch Duct B type. Seventeen out of 19 Main duct types (89%) were histologically diagnosed as neoplasms including 13 lesions of cancer and 4 of adenoma. All the Branch Duct A type cases were diagnosed as hyperplasias. 23 Branch Duct B type cases contained 7 cancers, 8 adenomas, and 8 hyperplasias. In the Main Duct type, benign or malignant, the diagnostic ability of balloon ERP-CS was calculated as sensitivity 100%, specificity 40%, and accuracy 84%; in the Branch Duct type, sensitivity 73%, specificity 86%, and accuracy 82%. On EUS, it was found that the size of the tumor in the cyst, with respect to the maximum diameter as well as height, correlated well with the grade of malignancy. All tumors (n=35) greater than 20 mm in diameter were found to be cancerous. These findings indicate that the MPPT is highly suggestive of neoplasms when the dilatation of the main pancreatic duct is detected by balloon ERP-CS and when, in a case without dilatation of the main pancreatic duct, a nodular lesion greater than 10 mm in diameter is identified in the cyst by balloon ERP-CS as well as EUS. Our current patient management strategy for operations is as follows: Main Duct type patients and Branch Duct type patients with a nodular defect detected by balloon ERP-CS and with an elevation of more than 10 mm in EUS should have an operation. Other Branch Duct type patients without main pancreatic duct dilatation are followed up by balloon ERP-CS. PMID- 9951853 TI - Mucin-producing tumor of the pancreas--intraluminal ultrasonography. AB - BACKGROUND/AIMS: Many patients with mucin-producing pancreatic tumor, characterized by dilatation of the pancreatic duct, are diagnosed by conventional ultrasonography in a mass ultrasonographic survey in Japan. It is a necessary and reliable method for making a precise diagnosis and for deciding on the treatment approach. Endoscopic ultrasonography (EUS) is appreciated as a useful method for precise diagnosis of pancreatic tumors. Intraductal ultrasonography (IDUS) is expected to be a new modality for the more detailed diagnosis of pancreatic tumors. METHODOLOGY: Endoscopic ultrasonography and intraductal ultrasonography were performed in 23 patients with mucin-producing pancreatic tumor. The differences in ultrasonographic findings between benign and malignant tumors were studied. RESULTS: Ultrasonographic findings of mucin-producing pancreatic tumor revealed by EUS and IDUS were: cystic lesion, mural nodule in the cystic lesion, wall thickness of the cyst, mucus echoes, and solid tumor with a mixed echo pattern. Seven out of 11 patients with mural nodule were diagnosed as carcinomas and another 4 patients had adenoma. Seven of 8 patients with mucus echoes were diagnosed as carcinoma. Three of 4 patients with solid tumor were diagnosed as invasive carcinoma. The ultrasonographic findings suggesting malignancy were: mural nodule, irregular wall thickness, mucus echoes, and solid tumor with a mixed pattern. Solid tumor indicated invasive carcinoma exclusively. CONCLUSIONS: Intraluminal ultrasonography, EUS and IDUS are very useful in making a differential diagnosis between benign and malignant tumors in mucin-producing pancreatic tumors. PMID- 9951854 TI - Characteristics and treatment of mucin-producing tumor of the pancreas. AB - BACKGROUND/AIMS: There has been no thorough clinicopathological analysis of a large number of cases with mucin-producing tumor of the pancreas. The aim of this study was to investigate the clinicopathological features of and therapeutic strategy for this ailment. METHODOLOGY: Two hundred and fifty-nine cases of mucin producing tumor of the pancreas were analyzed clinicopathologically. RESULTS: Mucin-producing tumor of the pancreas was found in 177 males and 82 females (M:F=2.2:1). The mean age was 65.5 years. Jaundice, diabetes mellitus and a past history of pancreatitis were found in 15-19% of the cases. The tumor was most frequently (62%) found in the head of the pancreas. Pathologically, hyperplasia or adenoma was found in 58 cases, and adenocarcinoma in 160 cases. Five-year survival rate by the Kaplan-Meier method was 82.6% in all of the cases, and the post-operative survival curve was much better in cases with this type of carcinoma than in cases with ordinary pancreatic duct cell carcinoma (5-year survival rate: 17.3%). Organ-function preserving procedures, such as duodenum preserving subtotal resection of the head of the pancreas or spleen preserving distal pancreatectomy, might be recommended for this disease without infiltration. CONCLUSIONS: Mucin-producing tumor has unique clinicopathological characteristics, such as the dilated main pancreatic duct or branches, dilatation of the orifice of the papilla of Vater, or a good prognosis. Organ-function preserving procedures should be recommended in some cases with this ailment. PMID- 9951855 TI - Surgery for mucin-producing pancreatic tumor. AB - BACKGROUND/AIMS: There is a diversity of mucin-producing tumors of the pancreas, including benign adenoma, malignant intraductal papillary carcinoma and invasive papillary carcinoma. However, there has been little discussion of appropriate techniques for surgically treating these tumors. METHODOLOGY: From August 1981 to December 1997, surgery was performed on 24 patients with mucin-producing pancreatic tumors (18 cases were malignant and 6 were benign). The surgical techniques which were used, the results of surgery, and the post-operative course of the patients are discussed. RESULTS: Surgical resection was possible in 23 patients and included: 4 cases of total pancreatectomy; 1 case of pancreaticoduodenectomy (Whipple's procedure); 1 case of Whipple's procedure with a transverse colectomy; 13 cases of pylorus-preserving pancreaticoduodenectomy (PPPD); 2 cases of duodenum-preserving pancreatic head resection (DPPHR); 1 case of resection of the posterior segment of the pancreas (posterior segmentectomy); and, 1 case of resection of the medial segment of the pancreas (medial segmentectomy). Surgical resection was also used for 17 (94.4%) of the 18 patients with malignant tumor. There were no fatalities during or immediately following surgery. One patient developed transient duodenal stenosis after DPPHR. The 5-year survival rate after surgical resection was 68.4% for the 17 patients with malignant tumor. Mucus leaked from the pancreatic duct into the operating field of 1 patient during pancreatectomy. This patient died 7 months after surgery from a tumor metastasis of the thoracic mediastinal lymph nodes and peritoneal seeding. This episode illustrates the high risk associated with leakage of pancreatic duct mucus into the operating field. The longest surviving patient, 13 years and 11 months after total pancreatectomy, has good health and shows no signs of recurrence. CONCLUSIONS: The prognosis for surgically resectable mucin-producing pancreatic tumors is better than that for invasive pancreatic duct carcinoma. When treating mucin-producing pancreatic tumors surgically, techniques which allow preservation of pancreatic and gastroenteric functions should be selected when possible. These techniques include PPPD, DPPHR and pancreatic segmentectomy. A total pancreatectomy should only be selected in cases where cancer has invaded the entire pancreas (especially when cancer has invaded the duct within the pancreatic head, through the tail). It may also be used when residual cancer cells have been detected by intra-operative pathological examination at the distal stump of the pancreas. During surgery with any technique, leakage of pancreatic duct mucus into the operating field must be avoided. PMID- 9951856 TI - Anomalous pancreaticobiliary ductal union--an etiologic association of gallbladder cancer and adenomyomatosis. AB - BACKGROUND/AIMS: Anomalous pancreaticobiliary ductal union (APBDU) has been proposed as a risk factor of gallbladder cancer. To clarify the frequency and the subtype distribution of APBDU in patients with gallbladder cancer and adenomyomatosis, a retrospective study was performed. METHODOLOGY: The radiograms of endoscopic retrograde cholangiopancreaticography of 680 patients with well documented biliary and pancreatic ducts from April 1992 to November 1996 were reviewed. The length of the common channel and insertion of the pancreatic duct and the bile duct were identified and recorded. RESULTS: Gallbladder cancer and adenomyomatosis were identified in 8 and 12 patients, respectively. Patients with gallbladder cancer were significantly older (mean age: 66.5 years, p<0.01) than those with gallbladder adenomyomatosis (mean age: 42.7 years). APBDU was noted in 59 (8.7%) of 680 cases with complete pancreaticobiliary radiograms. Among them, 5 of 8 patients with gallbladder cancer coexisted with APBDU. Four (80%) belonged to the P-B type. Six of 12 patients with gallbladder adenomyomatosis had APBDU. Five (83.3%) belonged to P-B type. CONCLUSIONS: Patients with gallbladder cancer and adenomyomatosis were frequently associated with APBDU. The close relationship and similar distribution of the P-B type of APBDU in both diseases suggest an etiologic association in various gallbladder diseases. PMID- 9951857 TI - Prospective randomized trial of 5-fluorouracil, doxorubicin, and mitomycin C for non-resectable pancreatic and biliary carcinoma: multicenter randomized trial. AB - BACKGROUND/AIMS: The efficacy of combination chemotherapy, which consists of fluorouracil, doxorubicin and mitomycin, was compared with that of palliative surgery-only in patients (control) having non-resectable pancreatic and biliary carcinomas in a multicenter randomized trial. METHODOLOGY: The patients were assigned to combination chemotherapy consisting of concomitant 5-fluorouracil 200 mg/m2, doxorubicin 15 mg/m2, and mitomycin 5 mg/m2 by intravenous administration. This combination chemotherapy was given concurrently as the initial dose within 1 week after palliative operation, and this regimen was repeated for at least 2 whole courses at 4-week intervals before the next course of therapy. Forty-two cases of this combination chemotherapy group and 41 of the control group were completely eligible for analysis. RESULTS: Regarding the overall 50% inhibition of tumor progression and that of gallbladder carcinoma, there were significantly better outcomes in the modified FAM therapy group. In this group, tumor reduction was achieved in 1 complete response (CR) and 2 partial response (PR) patients. With respect to the overall and differentiated survival times according to the tumor sites and the clinical efficacy, there was no difference between the groups. The most frequent adverse reactions were gastrointestinal manifestations such as anorexia, nausea, vomiting, and diarrhea; also noted was alopecia. CONCLUSIONS: Since this combination chemotherapy inhibited the tumor progression for significantly longer duration and, to a lesser extent, reduced the tumor size in non-resectable gallbladder carcinomas compared to a non-administrated chemotherapy group, this study will function as the basis for pursuing a more effective chemotherapy. PMID- 9951858 TI - Relative merits of ultrasonography, computed tomography and cholangiography in patients of surgical obstructive jaundice. AB - Fifty consecutive patients with surgical obstructive jaundice were evaluated prospectively with ultrasonography (US), computed tomographic scans (CT scan) and cholangiography-percutaneous transhepatic cholangiography (PTC) or endoscopic retrograde cholangio-pancreaticography (ERCP). The diagnostic accuracy of ultrasound in defining the level of obstruction was 86% as compared to 86% and 94.8% for CT scan and cholangiography, respectively. To measure the etiology of the obstruction, the accuracy of ultrasound, CT scan and cholangiography were 84%, 86% and 75%, respectively. The sensitivity of CT scans and cholangiography in the diagnosis of choledocholithiasis was 100%, 81.8% and 90%, respectively, whereas specificity was 97%, 100% and 100%, respectively. Sensitivity for a diagnosis of malignant disease was 100% for both US and CT scans whereas specificity was 90% and 81%, respectively. Ultrasonography as a single radiological investigation is sufficient in the evaluation of the majority of patients with surgical obstructive jaundice. CT scan and cholangiography should be done only when US gives equivocal findings or if concomitant therapeutic procedures like basketing and stenting are also planned. PMID- 9951859 TI - Evaluation of cholesterol absorption in rats using markers labeled with stable isotopes. Effect of complete bile diversion. AB - BACKGROUND/AIMS: An easily performed method to measure cholesterol absorption with isotope labeled cholesterol and beta-sitostanol in humans is described. The first aim of the study was to show whether this method can also be used in rats. Secondly, to see whether complete bile diversion results in a complete loss of cholesterol absorption. METHODOLOGY: Cholesterol absorption was evaluated in rats by the constant isotope feeding method using [2H6]cholesterol and [2H4]sitostanol as markers. Fecal samples were analyzed by gas-chromatography/mass spectrometry. RESULTS: In 8 rats with intact enterohepatic circulation of bile acids, cholesterol absorption averaged 61 (3% (SD) (range: 54-69%)). Complete bile diversion was followed by an almost total loss of cholesterol absorption (5.5+/ 0.6%, range: 2.4-6.9%, n=7). CONCLUSIONS: The results indicate that deuterated cholesterol and deuterated sitostanol are reliable markers for measurement of cholesterol absorption in rats and that bile acids are essential for cholesterol absorption. PMID- 9951861 TI - Urgent bedside endoscopic nasobiliary drainage without fluoroscopic monitoring. AB - Emergency endoscopic nasobiliary drainage was performed successfully in 2 patients with severe cholangitis and septic shock without the help of fluoroscopy because of technical problems in the fluoroscopy units. Definitive procedure was performed after the recovery. Nasobiliary drainage can be performed without fluoroscopic guidance, but should be attempted in exceptional situations. PMID- 9951860 TI - Traumatic biliary stricture successfully treated by percutaneous transhepatic bile duct dilatation: a case report. AB - A 24 year-old woman complained of obstructive jaundice 24 days after blunt abdominal trauma due to a traffic accident. Endoscopic retrograde cholangiopancreatography (ERCP) revealed a stricture, 15 mm in length, at the common bile duct associated with upper bile duct dilatation. Jaundice was reduced by percutaneous transhepatic cholangio-drainage (PTCD). A 7 Fr-sized PTCD tube was exchanged for a larger-sized catheter for percutaneous transhepatic cholangioscopy expecting gradual dilatation of the stricture. Following the confirmation of satisfactory dilatation of the stricture, the catheter was removed. There was no recurrence of jaundice 16 months later in a follow-up study. PMID- 9951862 TI - Diffuse papillomatosis of the gallbladder: case report of a hydropic gallbladder. AB - We present the case of a 47 year-old man with a gallbladder papillomatosis. His medical history showed typical biliary symptoms with chronic colicky pain and two episodes of jaundice. Unusually, the patient himself discovered a right hypochondrial mass which appeared to be a hydropic gallbladder. Pre-operative diagnosis was done by ultrasonography and percutaneous cholecystography. A cholecystectomy was performed. Gross description and microscopic examination confirmed the diagnosis of benign diffuse papillomatosis involving the entire mucosal surface of the gallbladder. The clinical and anatomical aspects of this lesion are discussed. PMID- 9951863 TI - Ischemic biliary stricture due to lymph node dissection in the hepatoduodenal ligament. AB - We report on 2 cases of ischemic biliary stricture after radical lymphadenectomy in the hepatoduodenal ligament with skeletonization of the extrahepatic bile ducts for malignant diseases. In both cases, histologic examination of the subsequently resected biliary strictures revealed evidence of ischemia. Skeletonization of the bile ducts may result in ischemia and stricture formation. In patients who require thorough dissection of the hepatoduodenal lymph nodes, bile duct resection should be considered. PMID- 9951865 TI - Blood supply of esophageal stumps. AB - BACKGROUND/AIMS: The purpose of the study was to determine the blood supply of stumps of mobilized esophagus. METHODOLOGY: Esophageal stumps of five groups of rabbits were studied. The esophageal stumps were dyed via intravenous injection of trypan blue, and were analyzed by color image processing. RESULTS: The dyed length of the esophageal stump was 7.15+/-0.5 cm in the stomach-connecting group; 4.6+/-0.69 cm in the stomach-connecting with myotomy group; 6.1+/-0.88 cm in the distal stomach-connecting group; 3.0+/-0.47 cm in the neck-connecting group; and, 2.1+/-0.2 cm in the neck-connecting with myotomy group. There was a significant difference in the dyed length between the stomach-connecting and neck-connecting groups (p=0.000), and between the stomach-connecting and stomach-connecting with myotomy groups (p=0.026), but there was no significant difference between the neck-connecting and neck-connecting with myotomy (p=0.094), or the stomach connecting and distal stomach-connecting groups (p=0.053). CONCLUSIONS: Stumps of the mobilized esophagus in rabbits, with or without myotomy, exhibit differences in dyed length, depending on the diameter, wall thickness and location of the blood supply in the esophagus. PMID- 9951864 TI - Water enhanced "non-paralytic" transcutaneous ultrasound of the normal gastric wall layers (WETCUS). AB - BACKGROUND/AIMS: Barium studies, endoscopies and endoscopic ultrasound are the usual methods for gastrointestinal tract examinations. Endoscopic ultrasound was the only accurate equipment used for imaging the various layers of the stomach wall distinctly. METHODOLOGY: Twenty patients undergoing renal ultrasound were given 600 cc of water to drink. Gastric wall layers were demonstrated in all patients, namely mucosa; submucosa, musculosa and serosa. The echogenic layer of the water-mucosa interface was not included in gastric wall thickness measurement. RESULTS: The normal wall measurement varied from 3-5 mm. This is lower than in previous reports. CONCLUSIONS: Water enhanced "non-paralytic" transcutaneous ultrasound is a simple, safe, non-invasive, and accurate test for visualizing gastric wall layers. PMID- 9951866 TI - Evaluation of percutaneous endoscopic gastrostomy in a university hospital. AB - BACKGROUND/AIMS: Percutaneous endoscopic gastrostomy (PEG) has become a commonly performed procedure to provide nutritional support for chronically ill patients. The aim of this study was to review the safety and results of PEG in a teaching hospital. METHODOLOGY: A retrospective review of 44 patients who underwent PEG procedure. The indication was long-term enteral feeding in patients who were unable to maintain adequate nutrition by mouth with an otherwise functioning gut. The most common primary diagnosis was cerebrovascular accident (17 patients). All patients were unable to swallow. RESULTS: There were six (13.6%) minor complications, and two mortalities from peritonitis (4.5%). The most common complication was gastrostomy site infection, which did not require exchange of the feeding tube. CONCLUSIONS: PEG is a useful means of providing nutrition in patients unable to swallow without the necessity for laparotomy and general anesthesia. This method provides an adequate avenue for enteral alimentation in selected patients and is relatively safe. Careful attention to the technique of insertion is important to prevent leakage or bowel perforation. PMID- 9951867 TI - What is the association of primary sclerosing cholangitis with sex and inflammatory bowel disease in Turkish patients? AB - BACKGROUND/AIMS: In the Western world, primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that is associated with inflammatory bowel disease (IBD), particularly chronic ulcerative colitis and, to a lesser degree, Crohn's disease. The goal of this study was to determine the prevalence of PSC in Turkish patients with IBD and chronic amebic colitis, a disease that is endemic in Turkey. METHODOLOGY: During a 10-year period, between 1986 and 1996, a total of 81 IBD (64 ulcerative colitis and 17 Crohn's disease) patients and 127 patients with chronic amebic colitis were seen and evaluated with radiologic, serologic, immunologic and pathologic tests. Whenever a clinical or biochemical finding suggested the presence of co-existent hepatic and/or biliary disease, the patient was further evaluated by liver biopsy, auto-antibodies and endoscopic retrograde cholangiopancreatography (ERCP) to determine whether they also had PSC or some other form of liver disease. As a disease control group, a total of 752 patients with clinical and/or laboratory evidence of pancreaticobiliary disease were also studied. In 86 of these 752 patients (10%), a primary disorder of the biliary tree was diagnosed by ultrasonography, computed tomography, peritoneoscopy, liver biopsy, ERCP and abdominal laparotomy. In addition, all 86 patients of the control group were evaluated endoscopically in order to determine whether they had any associated gastrointestinal condition of the upper or lower gastrointestinal tracts. After establishing final diagnoses of IBD, amebic colitis and PSC, these patients were evaluated with respect to their socio economic status. A high protein diet (1.8 gram/kg/day) was administered to those patients with chronic amebic colitis and IBD during the active period of the disease. RESULTS: Of the 208 patients (81 with IBD and 127 with chronic amebic colitis), no cases of PSC were identified. Of the 86 patients in the control group with primary biliary tract disease, 45 had a biliary system malignancy, 14 had primary biliary cirrhosis (PBC), 16 had PSC, 3 had Caroli's disease, 6 had a common bile duct cyst, and 2 had gallbladder adenomatosis. All but 1 of the 16 patients with PSC were female. CONCLUSIONS: These data suggest that, in contrast to findings in Western Europe and the USA, in Turkey: 1) PSC is not regularly associated with idiopathic IBD; 2) most patients with PSC are female; 3) PSC accounts for only 18% of patients with a primary disorder of the biliary tree; 4) the incidence of small-duct primary sclerosing cholangitis is greater than that reported in the literature; and, 5) the incidence of IBD and PSC in Turkey is relatively lower than in other countries. PMID- 9951868 TI - Percutaneous cholangiofiberscopic endoluminal forceps biopsy of intrabile duct diseases. AB - BACKGROUND/AIMS: The aim of the present study was to determine the usefulness and sensitivity of percutaneous cholangiofiberscopic guided forceps biopsy in patients suspected of intrabile duct diseases. This study also emphasized the use of a video monitor system in which the field of view is magnified; thus, even a small lesion can easily be detected. Furthermore, coordination of both the operator and assistant is easier because both can observe the image together on the video monitor. METHODOLOGY: Percutaneous cholangio-fiberscopic forceps biopsy was performed in 27 patients (14 men, 13 women, aged 37-81 years with a mean age of 61 years). A mature T-tube tract was used as an access for cholangioscopy in 17 cases while the remaining 10 patients underwent percutaneous transhepatic biliary drainage and gradual tract dilatation from 7-French to 16-French. A flexible fiberoptic choledoscope was gently inserted into a mature tract and once an abnormal mucosal lesion was identified, a forceps biopsy was inserted into a working channel of the scope, and 3-5 specimens were taken for histological examination. RESULTS: A histological diagnosis was obtained in 24 cases of the 27 patients (sensitivity 89%) and included cholangiocarcinoma (n=8), papillomatosis (n=3), ampullary adenoma (n=1), ampullary adenocarcinoma (n=1), hepatoma with intrabile duct invasion (n=1), and chronic inflammation (n=10). Post-procedural bleeding was noted in 1 patient. CONCLUSIONS: Percutaneous cholangiofiberscopic guided forceps biopsy is a safe and easy to perform procedure. It yielded a high sensitivity rate for definitive diagnosis of very small or early intrabile duct lesions; thus, a curative therapeutic modality can be appropriately applied. The use of a video monitor system, which magnified the field of view without distorting the quality of the image, plays a crucial role in this technique. Mucin substance is commonly seen in cholangiocarcinoma. The association between bile duct stones and neoplasm needs further evaluation. PMID- 9951869 TI - Continuous hyperthermic peritoneal perfusion for peritoneal dissemination of gastric cancer. AB - BACKGROUND/AIMS: We investigated the histological and clinical effectiveness of continuous hyperthermic peritoneal perfusion (CHPP) for treating peritoneal dissemination (therapeutic CHPP) and for the prevention of peritoneal recurrence (prophylactic CHPP). METHODOLOGY: In 5 patients with gastric cancer and peritoneal dissemination, the apoptosis index of the cancer cells on in situ end labeling for detection of apoptotic cells was 3.0+/-1.2% before CHPP, and had increased to 52.9+/-8.3% after CHPP. The survival curve of the therapeutic CHPP group was significantly better than that of the control group. The therapeutic CHPP group was classified as miliary type or nodular type. The survival curve in the miliary type was significantly better than that in the nodular type. RESULTS: In prophylactic CHPP, there was no improvement in prognosis, but a prophylactic effect against peritoneal recurrence was demonstrated in the patients who were n4 negative when the mean intraperitoneal temperature during CHPP (MIT) was maintained above 42 degrees C. CONCLUSIONS: These results indicated that an improved prognosis can be expected after therapeutic CHPP in patients with peritoneal spread. The beneficial effects are especially marked in patients with the miliary type. Moreover, prophylactic CHPP exerts a prophylactic effect against peritoneal recurrence in patients with n4 negative, providing that the MIT can be maintained above 42 degrees C. PMID- 9951870 TI - Intact tissue of gastrointestinal cancer specimen orthotopically transplanted into nude mice. AB - BACKGROUND/AIMS: A relevant animal model of human gastrointestinal cancer in nude mice, which can be adapted for repetitive investigations, could improve our understanding of carcinogenesis and cancer metastasis. Furthermore, it may support the development of new and effective therapeutic concepts. METHODOLOGY: We have established an orthotopic transplantation tumor model for human tumors in nude mice with intact tissues of colorectal, pancreatic, and gastric cancer. We investigated the biological characteristics of original and corresponding transplanted tumors, including routine pathological examination (HE staining), mucin production (PAS staining), and immunostaining. In addition, the lung and liver specimens were screened for micrometastases. RESULTS: 1) Overall, 10 out of 22 surgical specimens were growing in nude mice subcutaneously and/or orthotopically (4/6 colon, 5/10 pancreatic, and 1/6 gastric cancer). In the group of fresh tumor tissues with greater than 50% tumor cell content, the take rate was 100% (3/3 pancreatic, and 3/3 colon). 2) The orthotopically transplanted tumors resemble the original tumors morphologically and biologically, including local invasion, regional and distant metastases, and CEA production. 3) The detection of dissemination of cancer cells can be achieved by immunostaining. CONCLUSIONS: An orthotopic xenotransplantation model for human gastrointestinal carcinomas in nude mice was established. The comparative analysis by immunohistochemistry suggests that this study will be helpful for developing new diagnostic methods to monitor micrometastatic disease. PMID- 9951871 TI - Multiple parapapillary choledochoduodenal fistulas with ampullary carcinoma. AB - Only very rarely do multiple parapapillary choledochoduodenal fistulas occur concurrently with ampullary carcinoma. The following presents just such a case, which occurred in a 51 year-old Japanese female hospitalized for epigastralgia. Gastrointestinal fiberscopy (GIF) showed abnormal swelling of Vater's papilla. She was diagnosed as having ampullary carcinoma and choledochoduodenal fistulas, as determined by hypotonic duodenography (HDG), endoscopic retrograde cholangiopancreatography (ERCP) and from the histopathology of the ampullary mucosal biopsy. Pancreatoduodenectomy was performed. We postulated that the multiple fistulas were formed on the longitudinal fold of Vater's papilla by an ampullary carcinoma, and that the fistulas played a major role in bile drainage. As a result, jaundice was not seen throughout the entire clinical course. We report on the mechanism of fistula formation, with a review of the recent literature. PMID- 9951873 TI - Colonoscopic diagnosis of whipworm infection. AB - Trichuriasis is an intestinal infection found in human beings which is caused by Trichuris trichiura, more commonly known as whipworm because of its whip-like appearance. It is characterized by the invasion of the colonic mucosa by the adult Trichuris and produces minor inflammatory changes at the sites of localization. It is prevalent throughout the world, especially in tropical areas. Its diagnosis is usually made by identification of the typical eggs in the stool; adult whipworm is rarely seen during colonoscopy. Colonoscopy can directly diagnose trichuriasis, confirming the threadlike form of worms with an attenuated end. The worms can be overlooked, particularly if colon preparation is imperfect. Attenuated whip-like ends of whipworms, which are embedded in the colonic mucosa, were removed with biopsy forceps. We report on 5 cases of whipworm infection that were diagnosed on total colonoscopy. PMID- 9951872 TI - Lymphangiomatous cysts of the spleen: report of 3 cases and review of the literature. AB - Splenic cysts are very uncommon entities. The majority of these cysts are solitary and asymptomatic. They are mainly seen in children or young adults; and, they are usually seen either as solitary or multiple. For all splenic cysts, surgical intervention is advantageous, as the risk of splenic rupture is very high, even from minor abdominal injury. This report presents a summary of 3 cases with lymphangiomatous splenic cyst that were treated at the Gastroenterology Surgical Center, Mansoura University, Egypt from 1993 to 1996. Lymphangiomatous cyst of the spleen is considered a rare type of cyst that is usually found as a single or multi-cystic lesion. PMID- 9951874 TI - Hydatid liver cyst perforation into the digestive tract. AB - Complications of liver hydatid disease include those related to the compression of adjacent viscus, to the infection of the cyst's contents or to the perforation of the cyst. Perforations into hollow abdominal organs are rare, and can occur secondary to the infection of the cyst or to a primary pathology of the perforated organ. We report on 2 cases of perforation of a liver cyst into the duodenum, 1 due to the presence of a duodenal ulcer, and 1 secondary to a hydatid abscess. The surgical treatment of the lesions and their complications was, in both cases, successful. PMID- 9951875 TI - Giant intraluminal fibrovascular polyp of the esophagus. AB - Giant polyps of the esophagus are relatively rare. Without previous history, the diagnosis of the disease is difficult to be made by esophagography and esophagoscopy. A case of giant intraluminal fibrovascular polyp (13x4x3.5 cm) of the esophagus is presented. The polyp was retrieved from the esophagus by a Foley's catheter and resected via the oral route. PMID- 9951876 TI - Dihydropyrimidine dehydrogenase but not thymidylate synthase expression is associated with resistance to 5-fluorouracil in colorectal cancer. AB - BACKGROUND/AIMS: In planning adjuvant treatment of colorectal cancer, it is of critical importance to optimize the treatment by identifying subsets of patients that will respond or not to chemotherapy. Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are key enzymes involved in the biochemical functions of the antimetabolite 5-fluorouracil (5-FU). In searching for the factors determining the 5-FU sensitivity of colorectal cancer, TS and DPD were analyzed in relation to the inhibitory effect of 5-FU on cell proliferation in a series of human colorectal cancer cell lines. METHODOLOGY: TS and DPD protein expressions were quantified in 5 human colorectal cancer cell lines, using TS binding assay and Western blotting, respectively. Cellular growth inhibition was assessed by MTT assay after 48 hours of continuous exposure to 5-FU or cisplatin (CDDP). RESULTS: TS protein expression was detected in all but one of the cell lines studied and varied within a 17-fold range, while DPD protein expression was detectable in only one cell line (CaR1). CaR1, which expressed the highest level of DPD and no detectable TS, showed remarkable resistance to 5-FU. The other colorectal cancer cell lines with undetectable DPD expression were sensitive to 5 FU. There was no correlation between TS expression and 5-FU sensitivity. All of the cell lines studied showed similar sensitivity to CDDP. CONCLUSIONS: These data suggest that DPD, but not TS, expression predicts 5-FU sensitivity in colorectal cancer cell lines. PMID- 9951877 TI - Ileoanal anastomosis for ulcerative colitis: results of an evolutionary surgical procedure. AB - BACKGROUND/AIMS: Proctocolectomy with ileoanal anastomosis (IAA) has proved to be the most suitable surgical treatment for ulcerative colitis. The aim of this study was to compare the results of IAA according to the evolution of surgical procedures and particularly to compare the results of stapled versus hand-sewn anastomosis. METHODOLOGY: From 1984 to 1996, 37 men and 31 women were operated on in our centre for ulcerative colitis. The anastomosis between the J pouch and the dentate line was handsewn in 35 patients (group 1) and stapled in 33 patients (group 2). RESULTS: The mean operative time was significantly shorter in group 2 as compared with group 1 (265+/-59 vs. 323+/-53, p<0.01, respectively), whereas morbidity and functional results were comparable in both groups. In 10 patients with stapled IAA, a diverting ileostomy was not performed and the morbidity in this group did not increase. CONCLUSIONS: These results suggest that stapled IAA anastomosis is a safe procedure. The stapling technique of IAA simplifies total excision of the rectum and could mean that a diverting ileostomy is not necessary. PMID- 9951878 TI - Intra-operative detection of lymph node involvement in carcinoma of the colon. AB - BACKGROUND/AIMS: We studied the accuracy rate of intra-operative lymph node assessment compared with pathological examination to determine whether surgeons could modify the extent of lymphadenectomy during the operation. METHODOLOGY: Intra-operative and pathological lymph node assessments were compared in 360 patients with carcinoma of the colon. RESULTS: A total of 6,431 lymph nodes were examined, mean number per patient was 17.9. The overall accuracy rate of intra operative diagnosis was 56.1%, sensitivity was 93.2%, and specificity was 41.7%. The accuracy rate of the diagnosis of N1 and N2 was 43.7% and that of N3 and N4 was 78.3% (p=0.001). There was no significant difference in the diagnosis rates in the colonic region. These results indicated that diagnosis in < or = N3 was more accurate than that in > or = N2. There were 5 false-negative cases. All of the false-negative lymph nodes were located adjacent to the colonic wall. CONCLUSIONS: Intra-operative diagnosis of the positivity of < or = N2 lymph nodes was too poor to decide the extent of lymph node dissection of < D2. It is adequate to dissect according to at least the D2 criteria in all cases. If the surgeon observes N3 involvement, he should add the D3 dissection. PMID- 9951879 TI - Antineutrophil cytoplasmic antibodies in Estonian patients with inflammatory bowel disease. Prevalence and diagnostic role. AB - BACKGROUND/AIMS: In Estonia, the incidence of ulcerative colitis and especially Crohn's disease appears to be rare. Antineutrophil cytoplasmic antibodies (ANCA) are frequently found in ulcerative colitis but less frequently in Crohn's disease, their pathophysiological significance is still unclear. METHODOLOGY: Fifty-nine serum samples from patients with ulcerative colitis, 17 with Crohn's disease, 25 with irritable bowel syndrome, and 86 healthy persons were studied. Sera were analyzed for the presence of ANCA by indirect immunofluorescence, and enzyme-linked immunosorbent assay for specific ANCA using different antigens was performed. RESULTS: ANCA were detected in 29 of 59 (49%) patients with ulcerative colitis, 4 of 17 (24%) patients with Crohn's disease, and in 4 of 111 (4%) controls. The immunofluorescence staining was mostly perinuclear (pANCA). There was no correlation between ANCA and the duration or extent of the inflammatory bowel disease. In specific enzyme-linked immunosorbent assays, only 14 sera elicited binding above the normal range. CONCLUSIONS: Although the prevalence of ulcerative colitis and Crohn's disease in Estonia is much lower than in European countries, there seem to be no differences in the presence of ANCA. PMID- 9951880 TI - Oxygen desaturation during sedation for colonoscopy in elderly patients. AB - BACKGROUND/AIMS: Conscious sedation increases the tolerance of patients to endoscopic examination, but arterial oxygen desaturation during endoscopy has often been reported. Elderly patients are considered to be at special risk. However, sedation-induced changes in cardiovascular function in the elderly have not been well investigated. Therefore, this study examined the effects of sedation on pulse rate, systolic blood pressure, and arterial oxygen saturation in elderly patients. METHODOLOGY: Twenty patients aged less than 60 years and 20 patients aged 60 years or more, scheduled to undergo colonoscopic removal of colorectal polyps, received 0.05 or 0.025 mg/kg body weight, respectively, of midazolam intravenously. Before, during, and after endoscopy, pulse rate, systolic blood pressure, and arterial oxygen saturation were recorded every 5 min with a pulse oximeter. RESULTS: Administration of midazolam had no significant effect on pulse and arterial systolic blood pressure in either group. In contrast, midazolam significantly reduced the levels of arterial oxygen saturation during and after endoscopy in both age groups. However, although patients aged 60 years or more received midazolam at half dosage, arterial oxygen saturation during endoscopy was significantly lower and the incidence of 5% or more oxygen desaturation was significantly higher than in the patients aged less than 60 years. CONCLUSIONS: Midazolam increases the tolerance of elderly patients to endoscopy, but it significantly lowers the level of arterial oxygen saturation and increases the incidence of desaturation. Continuous monitoring is especially valuable during endoscopy in the elderly. PMID- 9951881 TI - Colorectal cancer in patients over 80 years of age. AB - BACKGROUND/AIMS: The aim of the study was to compare the short- and long-term outcome of older and younger patients treated for colorectal cancer. We also wanted to study whether age was independently associated with post-operative mortality. METHODOLOGY: We conducted a retrospective study of 503 consecutive patients treated for colorectal cancer. One hundred and six (21%) were 80 years of age or older. The median follow-up was 5.5 years (2-16.8 years) or until death. RESULTS: Post-operative mortality was 6% (0.7% in patients less than 65 years and 16% in patients over 80 years). Multiple logistic regression analysis showed that age, emergency operation, advanced T-stage, and ASA-class were each independently related to post-operative mortality. The overall estimated 5-year survival rate was 59% in patients less than 65 years and 24% in patients over 80 years. The cancer specific 5-year survival was 62% in patients less than 65 years and 45% in patients over 80 years. CONCLUSIONS: The study demonstrated that age was an independent risk factor for post-operative mortality. In very old patients surviving the post-operative period, the long-term outcome was good. Advanced age alone should not be used as a criterion to deny surgery for colorectal cancer. PMID- 9951882 TI - Laparoscopic approach in acute small bowel obstruction. A review of 68 patients. AB - BACKGROUND/AIMS: Laparoscopic management of acute small bowel obstruction has potential advantages over classical laparotomy. The aims of this study were to assess the feasibility and the safety of this technique, as well as to find any predictive success factors. METHODOLOGY: A laparoscopic approach was undertaken in 68 out of 150 patients admitted between 1991 and 1997 for acute small bowel obstruction. RESULTS: The cause of obstruction was bands or adhesions in 80% of the patients. A correct laparoscopic diagnosis was established in 66% of the cases. A laparoscopic treatment was performed successfully in 31 patients (46%), and was assisted by minilaparotomy in 4 patients (6%), and by open herniorraphy in 2 patients (3%). Thirty-one patients (46%) needed a conversion to laparotomy. There were 6 bowel injuries (9%), all recognized during laparoscopy. There were 2 deaths in converted patients and 2 early reoperations for persisting ileus in patients treated by laparoscopy alone or by assisted laparoscopy. CONCLUSION: Acute small bowel obstruction can be treated by laparoscopy alone, or assisted by minilaparotomy or open herniorraphy with advantages for the patient and few complications despite a high rate of conversion. There were no pre-operative predictive factors for successful laparoscopy, except for an isolated previous scar from an appendectomy. Pre-operative predictive success factors were parietal intestinal adhesions, as the only cause of obstruction. Multiple adhesions will mostly require conversion to laparotomy. PMID- 9951883 TI - Well differentiated "lipoma-like" liposarcoma of the sigmoid mesocolon and multiple lipomatosis of the rectosigmoid colon. Report of a case. AB - Liposarcoma is the second most common soft tissue sarcoma in adults. These neoplasms take their origin from primitive mesenchymal cells and are rarely encountered in fat rich areas, such as subcutaneous tissue and/or the subserosa of the intestinal tract which, on the contrary, are the two most common sites of lipomas. The two major locations of liposarcomas are the extremities and the retroperitoneum followed with much less frequency by the inguinal region. Other sites are uncommon, particularly the mesentery (9 cases to date in the literature) and, even more so, the mesocolon (only 3 cases of primary sarcoma of the mesocolon reported to date). This paper reports on the case of a well differentiated "lipoma-like" liposarcoma of the sigmoid mesocolon, associated with multiple lipomatosis of the recto-sigmoid colon in a 75 year-old female patient. Surgical treatment consisted of a trans-anal extra-peritoneal anterior resection by CEEA 28 stapler under endoscopic vision. The patient has been followed up for the last 2 years and is still disease-free and well. The peculiarity of the case consists in the contemporaneous presence in close contiguity of two different rare neoplasms whose association is not yet known. PMID- 9951884 TI - Spontaneous gastroduodenal perforation in cancer patients receiving chemotherapy. AB - BACKGROUND/AIMS: Spontaneous gastroduodenal perforation is a rare and lethal complication in cancer patients receiving chemotherapy. METHODOLOGY: Data of 9 patients with spontaneous gastroduodenal perforation occurring during chemotherapy were reviewed. RESULTS: All 9 patients were male with an average age of 54.4+/-2.5 years. The primary malignancies included 5 head and neck cancers, 2 esophageal cancers, 1 malignant lymphoma, and 1 hepatocellular carcinoma. Abdominal pain was the most common symptom. The average interval between the onset of symptoms and surgery was 2.9+/-0.7 days (range: 16 hours to 7 days). Perforation was located on the duodenum (6 patients) and on the lower part of the body of the stomach (3 patients). Simple closure of the perforation was performed on 8 patients, and subtotal gastrectomy on 1 patient. Culture of the ascitic fluid of 8 patients revealed E. coli, Klebsiella pneumoniae, streptococcus viridans, and enterococcus. Four patients (44.4%) had post-operative complications. The 30-day post-operative mortality was 44.4% (4/9). Three patients died of sepsis with multiple organ failure, and 1 died of hepatic failure. Age, anaemia, leukopenia, serum albumin levels, impaired renal or liver functions are not significant operative risk factors. Pre-operative shock is a significant factor in predicting operative mortality and complications. CONCLUSIONS: High index with suspicion of the disease with early treatment may improve survival of cancer patients with spontaneous gastroduodenal perforation. PMID- 9951885 TI - Acid suppression with ranitidine plus oral triple therapy improves ulcer healing but not Helicobacter pylori eradication. AB - BACKGROUND/AIMS: To evaluate whether the addition of 2 weeks of ranitidine to a 1 week oral triple therapy (OTT) regimen improved ulcer healing and H. pylori eradication. METHODOLOGY: Two hundred and eleven consecutive patients with an endoscopic diagnosis of active duodenal ulcer (DU) and a positive antrum biopsy for H. pylori were enrolled. Those attending the Hospital Vera Cruz (Group A, n=142) received a 14-day course of ranitidine (150 mg after breakfast and dinner) plus a 1-week OTT, consisting of bismuth subcitrate, (240 mg after the 3 meals), tetracycline (500 mg, 10 min before the three meals and at bedtime), and furazolidone (200 mg after breakfast and dinner). Patients from the Hospital das Clinicas (Group B, n=69) received the same OTT as Group A but without ranitidine. Patients underwent endoscopy again on average 40 days (range: 30-60 days) after completing therapy in order to assess ulcer healing and H. pylori status. RESULTS: Both schedules were equally efficient in eradicating H. pylori with 90% (128/142) eradication in group A, and 84% (58/69) in group B (p=0.2). In contrast, the addition of ranitidine to OTT improved ulcer healing when compared with OTT alone (96%, 137/142, vs. 70%, 48/69; p<0.001). CONCLUSIONS: Our results demonstrate that the association of acid suppression, obtained with 2 week ranitidine administration with OTT improved ulcer healing but did not enhance H. pylori eradication. PMID- 9951886 TI - Heavy bacterial loads of H. pylori may precipitate duodenal ulcer bleeding but not bleeding severity. AB - BACKGROUND/AIMS: To determine whether severity of Helicobacter pylori (H. pylori) infection is aggravated during acute duodenal ulcer bleeding and related to bleeding severity. METHODOLOGY: One hundred and thirty-eight patients with H. pylori-infected bleeding duodenal ulcer and 112 non-bleeding cases were included in the study. A comparison was made of the anti-H. pylori IgG titer, endoscopic finding, density of H. pylori (range: 1-5) in the antrum, and severity of antral gastritis (score: 0-3) between bleeding and non-bleeding cases. The role of H. pylori in bleeding cases was further analyzed to survey its relationship to the severity of bleeding judged by clinical parameters. The H. pylori status of patients with rebleeding within the first week was compared to that of the non rebleeding cases as well. RESULTS: The anti-H. pylori IgG titer and H. pylori density of the non-bleeding group were lower than those of the bleeding group (0.466+/-0.288 vs. 0.912+/-0.559, p<0.001; 2.13+/-1.02 vs. 3.34+/-1.32, p<0.001). The percentages of bleeding ulcers in the study cases increased in a trend as the density of H. pylori increased (density: 1-5; 32.7%, 33.8%, 57.4%, 81.3%, 91.4%, p<0.001). Although the severity of gastritis and density of H. pylori disclosed an upward trend as bleeding severity increased, only ulcer size was significantly associated with bleeding severity (p<0.05). The 10 cases with recurrent bleeding had higher bacterial density and serological titer than the 128 non-rebleeding cases (p<0.005). CONCLUSIONS: Heavy bacterial loads of H. pylori infection may precipitate bleeding episodes of duodenal ulcer. However, in bleeding duodenal ulcer, the status of H. pylori infection is not strongly associated with initial bleeding severity before therapeutic endoscopy. With the aim of enhancing hemostasis and preventing rebleeding, further studies could focus on diminishing the bacterial load of H. pylori during bleeding episodes. PMID- 9951887 TI - Primary malignant lymphoma of the duodenum: report of a case. AB - We present a case of long-term survival in primary malignant lymphoma of the duodenum treated with a curative surgical resection and post-operative chemotherapy. A 72 year-old man was admitted to our hospital complaining of epigastric discomfort. Endoscopy revealed an ulcerative tumor in the duodenal bulb. The tumor was diagnosed histologically as malignant lymphoma by endoscopic biopsy. A distal gastrectomy and duodenal bulb resection were performed with lymph nodes dissection. The tumor was histologically classified as B-cell phenotype, large cell, immunoblastic lymphoma of high grade, according to the Working Formulation. The patient received CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy after the operation, and he has no sign of recurrence during a follow-up period of 6 years. PMID- 9951888 TI - The usefulness of intra-operative endoscopy in Peutz-Jeghers syndrome: a case report. AB - The Peutz-Jeghers syndrome is an autosomal dominant inherited disease manifested by a combination of mucocutaneous pigmentation and gastrointestinal hamartomatous polyps that usually cause intussusception and intestinal hemorrhage. We report a case in which the patient has been followed-up on for 14 years and who underwent surgical and endoscopic polyp removal several times as well as one intestinal resection. This time, with the use of combined surgery and perioperative endoscopy, 27 polyps were removed, performing only 3 enterotomies. This is the highest number in one session to be reported in the literature. The usefulness of this technique is providing a "clean small intestine" that allows the patient a longer time interval between laparotomies and reduces the complications associated with multiple laparotomies and resections. PMID- 9951889 TI - Intra-operative measurement of the tissue blood flow for evaluating blood supply to the gastric tube for esophageal reconstruction. AB - BACKGROUND/AIMS: Anastomotic leakage after esophageal surgery is still the main reason for post-operative morbidity and mortality. We developed a reliable procedure for evaluating blood supply to the gastric tube after esophageal reconstruction. METHODOLOGY: After construction of the gastric tube, tissue blood flow was measured intra-operatively at the anastomotic sites using laser Doppler flowmetry. RESULTS: There was a distinct difference in tissue blood flow at the distal portion of the gastric tube. The tissue blood flow at the sites of attempted anastomosis was considerably decreased compared to the value of the gastric body (control site). CONCLUSIONS: By measuring tissue blood flow at the attempted anastomotic site intra-operatively using laser Doppler flowmetry, a sufficiently nourished gastric tube could be prepared. It was our hypothesis that total elimination of the ischemic portion would make esophagogastric anastomosis safer and more reliable. PMID- 9951890 TI - Endoscopic sclerotherapy to arrest uncontrolled variceal bleeding in cirrhotic patients with high surgical risk. AB - BACKGROUND/AIMS: In 20-50% of patients bleeding from esophageal varices, conservative procedures fail to obtain hemostasis and prevent early recurrence. METHODOLOGY: We retrospectively analyzed the efficacy and safety of endoscopic sclerotherapy in 66 cirrhotic patients with high surgical risk and persistence or recurrence of variceal bleeding in spite of adequate medical treatment (somatostatin and/or balloon tamponade). RESULTS: Emergency sclerosis controlled bleeding in 46 out of 66 patients (70%). The remaining 20 patients underwent additional procedures to arrest the hemorrhage, and 6 died because of massive bleeding. Early rebleeding occurred in 5 patients (10%). The mortality within 2 days, 1 week, and 6 weeks was 9%, 17% and 32%, respectively. Death was attributed to hemorrhage in 9 cases. Sclerotherapy was associated with complications in 9 patients (14%). CONCLUSION: These results suggest that emergency sclerotherapy is a safe and effective procedure in cirrhotic patients with high surgical risk and persistence or recurrence of bleeding after conservative hemostatic procedures. PMID- 9951891 TI - Timing and necessity of endoscopy in AIDS patients with dysphagia or odynophagia. AB - BACKGROUND/AIMS: Dysphagia and odynophagia are common problems with significant morbidity in acquired immunodeficiency syndrome (AIDS) patients. Endoscopy in AIDS patients with esophageal symptoms is valuable for diagnosis, but the timing and necessity of routine endoscopy remains controversial. METHODOLOGY: We retrospectively studied 40 AIDS patients undergoing upper gastrointestinal endoscopy. Among them, 25 patients were enroled with dysphagia and/or odynophagia and were put on empirical fluconazole treatment before endoscopic evaluation. RESULTS: Fourteen (56%) of 25 patients improved after fluconazole treatment, while 11 patients had persistent symptoms. Among the 14 patients with symptomatic improvement, 7 were found to have esophageal candidiasis which improved after continuation of fluconazole for 1-2 more weeks. The other 7 patients had a normal endoscopic appearance. In contrast, among 11 patients with persistent symptoms, there were 3 patients with azole-resistant candidiasis, 3 with cytomegalovirus esophagitis, 1 with herpes simplex virus esophagitis with candidiasis, 1 with Kaposi's sarcoma, and 3 with idiopathic esophageal ulcer. They were successfully treated with Amphotericin B, Ganciclovir, Acyclovior, and oral steroids, except for the patient with Kaposi's sarcoma. CONCLUSIONS: Routine endoscopy may not necessarily be indicated in every AIDS patient with dysphagia or odynophagia. Empirical fluconazole treatment can improve symptoms in 50% of patients. It is only indicated when patients have persistent symptoms after empirical treatment. With endoscopic examination, etiologic agents other than common candidiasis can be determined and the patients can thus be put on specific treatment. PMID- 9951892 TI - Successful conservative treatment for esophageal perforation by a fish bone associated with mediastinitis. AB - A 74 year-old man presenting with esophageal perforation associated with mediastinitis due to the swallowing of a fish bone is reported herein. Conservative treatment, including starvation therapy and the injection of antibiotic drugs, proved to be successful for this patient. Although the optimal treatment for esophageal perforation remains controversial, it is important to choose the appropriate strategies when treating cases of esophageal perforation with mediastinitis. PMID- 9951893 TI - Carcinosarcoma of the esophagus: three cases with immunohistological examination. AB - Carcinosarcoma of the esophagus is a rare malignant tumor with both carcinomatous and sarcomatous components. We present 3 cases of carcinosarcoma of the esophagus and discuss the histogenesis of the tumors. We performed immunohistochemical studies using various antibodies: anti-cytokeratin, anti-vimentin, anti-smooth muscle actin, anti-p53, and MIB 1 reacting with Ki-67 nuclear antigen. PMID- 9951894 TI - Squamous cell carcinoma of the thoracic esophagus following radiation therapy for breast cancer. AB - Between 1981 and 1995, 4 patients (3 females, 1 male; aged 48-80) were diagnosed with squamous cell carcinoma of the esophagus, following mediastinal irradiation for breast cancer. The interval between irradiation and the presentation of esophageal cancer was 10.75 years on average (7-19). The treatment consisted of: radiotherapy only; a partial esophagectomy with proximal gastrectomy without post operative radiotherapy; laser photocoagulation for a superficial tumor; and, palliative treatment including gastrostomy, tracheal photocoagulation and chemotherapy for 1 patient suffering from advanced stage cancer with tracheal invasion, respectively. Radiotherapy of the esophageal cancer (exclusive or adjuvant) should take into account previous esophageal radiation therapy. The indications of curative excision surgery are the same as for other types of esophageal cancer, but the anastomoses should be performed in a non-irradiated area. Excision by esophageal stripping without thoracotomy is contraindicated because of the presence of peri-esophageal sclerosis. Preventive measures in radiation therapy for breast cancer are suggested. PMID- 9951895 TI - Experimental technique of esophageal substitution: intrathoracic interposition of a pedunculated gastric tube (PGT) preserving cardiac function. Preliminary results. AB - BACKGROUND/AIMS: The authors present an experimental technique performed on piglets to replace a segment of the thoracic esophagus with a gastric tube pedunculated on gastroepiploic vessels transposed between proximal and distal esophageal segments, and consequently preserve cardiac function. METHODOLOGY: Four piglets aged between 30 and 75 days, weight 6-20 kg, underwent esophageal replacement with a gastric tube, length 6-10 cm (mean: 8 cm), constructed from the greater gastric curvature and pedunculated on the gastroepiploic vessels. The gastric tube thus obtained, it was transposed into the right hemithorax through a small opening in the diaphragm. Esophageal reconstruction was done by interposition of the gastric tube between the upper and lower esophageal stumps. RESULTS: The post-operative course was uneventful. An esophagogram on the 4th post-operative day showed no anastomotic leakage in all cases, and oral food intake could be commenced. At follow-up, the animals were found to be eating normally. CONCLUSIONS: This experimental technique could have important advantages over existing techniques of esophageal replacement: 1) cardiac function is preserved; 2) it is technically easy to obtain a gastric tube with a long vascular pedicle, so replacement up to the superior esophagus is possible; and, 3) in the post-operative period, no swallowing difficulties appear to occur. PMID- 9951896 TI - Neurophysiological basis of sympathetic nerve-preserving surgery for lower rectal cancer--a canine model. AB - BACKGROUND/AIMS: The relative contribution and interrelated compensation of sympathetic signals among sympathetic components in pelvic plexus remain undefined. This study was designed to investigate the genitourinary function in response to autonomic nerve preservation and severance using a canine model. METHODOLOGY: Eighteen mongrel dogs were randomly divided into 3 groups which received severance of the hypogastric nerves on either the right side, left side, or on both sides. The hypogastric nerves and sacral sympathetic trunks were electrically stimulated and the contraction pressure of the internal urethral orifice was measured immediately, at 1- and 3-month intervals. The ejaculation function and the length of time required to reach sexual orgasm were evaluated by manual penis-stimulation. RESULTS: The difference between the left and right sides of the normal hypogastric nerve in contribution to sympathetic signals was insignificant. Compared with the hypogastric nerve, the bilateral sacral sympathetic trunks were functionally trivial in controlling the closure of the internal urethral orifice. The preserved side of the hypogastric nerve compensated for the loss of sympathetic signals of the severed side within 1 month and, thereafter, remained stationary. In contrast, the functional compensation of bilateral sacral sympathetic trunks for the severed bilateral hypogastric nerves was insignificant. When the hypogastric nerve was preserved in one or both sides, all dogs maintained normal antegrade ejaculation. If bilateral hypogastric nerves were severed, 50.0% (3/6) of the dogs lost both emission and ejaculation function; 33.3% (2/6) presented with retrograde ejaculation; and, 16.7% (1/6) presented with combined retrograde ejaculation and reduced antegrade ejaculation. The time required to reach sexual orgasm was not affected by the severance of the hypogastric nerve. CONCLUSIONS: The normal genitourinary function could be maintained only when at least one side of the hypogastric nerve was preserved. PMID- 9951897 TI - Laparoscopic transgastric pancreatic pseudocystogastrostomy--first experience with extraluminal approach. AB - BACKGROUND/AIMS: Transgastric cystogastrostomy (Jurasz procedure) became a standard procedure in the treatment of mature pancreatic pseudocysts contacting the stomach. The first experience with laparoscopically performed transgastric cystogastrostomy under performing anterior gastrostomy is discussed. METHODOLOGY: Five ports were used. The anterior stomach wall was opened 2 cm in length. The communication channel with the pseudocyst was created by means of precise coagulation of the posterior stomach as well as the pseudocyst wall. The pseudocyst was evacuated and the stoma was completed by stapling with the EndoGIA lineal stapler 3 cm in length. The anterior stomach wall was also closed with EndoGIA stapler. RESULTS: Excellent results could be achieved. The pseudocyst resoluted within 1 month after the operation, and the anastomosis healed completely. The patient was discharged on the 8th post-operative day. The follow up for 1 year was free of complications. CONCLUSIONS: Laparoscopic pseudocystogastrostomy appears to be a reliable method for treatment of large size mature pancreas pseudocysts because it is a minimally invasive procedure with standardized stapler-performed anastomosis. However, this initial experience has to be confirmed with a large number of patients. PMID- 9951898 TI - The importance of increasing the number of gastric biopsies in the diagnosis of Helicobacter pylori. AB - BACKGROUND/AIMS: The role of Helicobacter pylori in various gastroduodenal diseases is universally accepted. In this study, we aimed to determine the proper number and sites of the gastric biopsies in order to achieve the highest diagnostic yield through the use of a urease test and histopathology. We also compared the histological findings encountered in patients who had Helicobacter pylori (H. pylori) colonization. METHODOLOGY: Fifty patients referred for upper gastrointestinal endoscopy for dyspeptic complaints were included in the study. Our mapping protocol included 2 biopsies from antrum and 2 biopsies from corpus. We obtained 2 biopsies from each biopsy site for urease test and histopathological assessment. Golden standard positivity for the presence of H. pylori colonization was defined as concomitantly positive urease test and histologically detected bacteria found at the same biopsy site. RESULTS: Forty three patients had H. pylori colonization. Colonization rates of H. pylori, sensitivities of urease testing, and histopathology in 4 biopsy sites were not statistically different. Sensitivity of urease testing was 81.4% for 1 biopsy and 100% for 4 cumulative biopsies. Sensitivities of histological assessment were 93% and 100% for 1 and 4 biopsies, respectively. CONCLUSIONS: Results of this study suggest that 2 biopsies for urease testing and 1 biopsy for histopathology obtained from the antrum or corpus of the stomach were sufficient to obtain the highest statistically significant diagnostic sensitivity. PMID- 9951900 TI - The epidemiology of hemorrhage from the upper gastrointestinal tract in the mid nineties--has anything changed? AB - BACKGROUND/AIMS: Gastrointestinal hemorrhage is a frequent medical problem and a significant cause of morbidity and mortality. The aim of this retrospective analysis, which was carried out at our institution, was to establish the causes of hemorrhage from the upper digestive tract during a 3-year period. METHODOLOGY: The retrospective study includes those patients in which urgent endoscopic investigations of the upper digestive tract were carried out between 1 January 1994 and 31 December 1996. RESULTS: 2150 patients were investigated: 797 women and 1353 men. The average age of our patients was 57 years (a 3-97 year span, SD+/-17). In 665 patients (35.8%), endoscopic investigation of the upper digestive tube revealed signs of acute hemorrhage or traces of previous hemorrhage. Endoscopic hemostasis was carried out in 577 cases (31.1%). Sequelae of ulcer disease were the cause of hemorrhage in 46.1% of investigated patients. Frequent causes of hemorrhage were also inflammatory, hemorrhagically-erosive changes of the gastric and duodenal mucosa (21.9%), ruptured esophageal varices (9.4%), and esophageal reflux disease (8.0%). In 13.6% of patients the cause of hemorrhage did not lie in the upper digestive tract. In 50.3% of cases the gastrointestinal hemorrhage manifested itself by the discharge of melenic feces, and in 33.1% by hematemesis. 47.2% of our patients were aged over 60. CONCLUSIONS: Also in our society sequelae of ulcer disease are the most significant cause of gastrointestinal hemorrhage. Hemorrhages are frequent in elderly patients who usually have accompanying diseases. PMID- 9951899 TI - Gastric emptying after gastric interposition for esophageal carcinoma: comparison between the anterior and posterior mediastinal approaches. AB - BACKGROUND/AIMS: Close observation and evaluation of the function of the transposed stomach after esophagectomy is essential. The present study uses the sulfamethizole capsule meal test to evaluate differences in gastric emptying between the anterior and posterior mediastinal approaches in patients undergoing esophagectomy. METHODOLOGY: Thirty-eight patients who underwent the esophagectomy and esophagogastrostomy for esophageal cancer were randomly divided into 2 groups: Group 1: anterior mediastinal approach, and Group 2: posterior mediastinal approach. Gastric emptying was studied using the sulfamethizole capsule meal test. Patients received sulfamethizole food capsules, 65 g of bread, and 150 ml of water. Plasma sulfamethizole levels were determined by high performance liquid chromatography (HPLC). RESULTS: Gastric emptying in both groups was significantly accelerated compared to healthy volunteers. Gastric emptying did not differ significantly between groups 1 and 2. CONCLUSIONS: The present data show that the sulfamethizole capsule meal test is an effective means of evaluating the emptying of the transposed stomach. Furthermore, when the stomach is used as an esophageal substitute following esophagectomy, gastric emptying does not differ according to the access route. PMID- 9951901 TI - Helicobacter pylori infection and age on the development of intestinal metaplasia -a multiple logistic regression analysis. AB - BACKGROUND/AIMS: Both intestinal metaplasia (IM) and Helicobacter pylori (H. pylori) infection have been linked to gastric carcinogenesis in an age-dependent manner. However, their relationship remains ill defined, especially with respect to age. METHODOLOGY: Three hundred and two asymptomatic subjects (167 males and 135 females; mean age 44.3+/-11.1 years) underwent complete endoscopic examination and biopsy at the antrum and the corpus. H. pylori infection was diagnosed according to histopathology and serology, while IM was determined by histopathology. RESULTS: Eighty-four patients (27.8%) had IM, while 185 patients (61.3%) were seropositive to H. pylori. The frequency of IM was higher in patients with gastric ulcer (9/14, 64.3%) than in those with minimal change (68/229, 29.7%) or duodenal ulcer (7/59, 11.9%), both p<0.01. Patients with IM had a higher mean age (49.5+/-14.1 vs. 42.3+/-9.0, p<0.01) and a higher H. pylori prevalence than those without IM (61/84, 72.6% vs. 124/218, 56.9%, p<0.01). The concordance rate of H. pylori infection between histopathologic and serologic diagnosis was lower in patients with IM (67/84, 79.8%) than those without (196/218, 89.9%, p<0.05). Using logistic regression analyses, the development of IM was noted to be independently related to both H. pylori infection (odds ratio=1.97, 95% confidence interval: 1.1(3.53)) and age (odds ratio = 1.93, 95% confidence interval: 1.51(2.47)). CONCLUSIONS: These data suggest that age and H. pylori infection are independent risk factors for the development of IM. Furthermore, H. pylori infection may have been underestimated in patients with IM because of the use of a single method of detection. PMID- 9951902 TI - Relationship between Helicobacter pylori infection, histological gastritis, and functional dyspepsia. AB - BACKGROUND/AIMS: It is still controversial as to whether or not Helicobacter pylori (H. pylori) infection, histological gastritis, and functional dyspepsia (FD) are intercorrelated. We prospectively evaluated patients with functional dyspepsia in an attempt to clarify this issue. METHODOLOGY: Eighty-eight consecutive patients with functional dyspepsia (age range: 18-84 years) who did not show disease(s) other than gastritis were investigated. In a questionnaire they were asked to report the presence or absence of 8 upper gastrointestinal (GI) symptoms and to score them from 0 (absence) to 3 (severe), whereupon a sum score was calculated. Forty age-matched subjects with a sum score of <3 served as controls. Biopsy specimens for histology, bacterial culture, and rapid urease test were taken. A C13-urease breath test was also performed in 122 subjects. RESULTS: H. pylori infection was present in 43% of patients with functional dyspepsia and 35% of control subjects (not significant (n.s.)). None of the symptoms were correlated with H. pylori infection. The median symptom sum score was 8.5 in H. pylori-positive and 9.5 in H. pylori-negative patients with functional dyspepsia (n.s.). Histological gastritis was strongly associated with H. pylori infection but was not correlated with any of the symptoms. CONCLUSIONS: In a prospective population of patients with functional dyspepsia, H. pylori infection or gastritis are not associated with specific or severe symptoms. Our data imply that H. pylori gastritis is not an important condition in the pathogenesis of dyspeptic complaints. PMID- 9951903 TI - Detection of interferon inhibitors or antagonists in gastrointestinal malignancies. AB - BACKGROUND/AIMS: The aim of this study was to investigate the IFN-inhibiting activity in sera from patients with gastrointestinal malignancies, exerted in a variety of cellular types, as well as to elucidate the determinants of cellular sensitivity to such IFN-inhibitors. METHODOLOGY: Sera from 16 patients with gastric cancer and 18 with colon cancer were tested, while sera from 37 healthy blood donors were used as controls. All serum samples, collected before any kind of treatment, were tested for IFN-blocking and endogenous IFN-like activity. These activities were determined by assaying the inhibition of the vesicular stomatitis virus specific cytopathic effect in three cell lines: A549 cells, intestine 407 and Chang liver cells. RESULTS: There was no endogenous IFN in any of the serum samples of patients or controls. Concerning the IFN blocking activity of serum, there was no significant difference between gastric and colon cancer, while a marked variability was prominent depending on the cell line used. 76.4% of serum samples exerted IFN-blocking activity in the A549 cells, 47.05% in the Int-407 cell line and 32.3% in the Chang Liver cells. No control sample had IFN-blocking activity in any of the cell lines tested. CONCLUSIONS: The results support a cytokine and cytokine inhibitors network, mediating pathophysiological events at the cellular level as well as the whole organism. The limited responsiveness of many neoplasias, including digestive system cancer, to IFN treatment might be due to the presence of IFN inhibitors in the patient's serum. PMID- 9951904 TI - Targeting locoregional immunochemotherapy with new drugs in metastatic liver disease: a promising alternative. AB - BACKGROUND/AIMS: A retrospective report of our experience with adjuvant targeted locoregional immunochemotherapy using new drugs in 29 Stage IV colorectal cancer patients with unresectable metastatic liver disease from September 1997 to December 1998. METHODOLOGY: After pre-operative screening, all patients were subjected to laparotomy for insertion of transhepatic and transplenic arterial catheters, both implanted subcutaneously in the right upper abdominal quadrant. A bolus transhepatic arterial chemotherapy using Eloxatine 150 mg/m2 and Campton 140 mg/m2, suspended in a 5:1 lipiodol-urografin emulsion, was given 15 days post operatively, followed the day after by 5 daily transplenic artery and then 5 daily transhepatic arterial injections of IL-2 in a 5:1 lipiodol-urografin mixture. This treatment schema was repeated at 2-month intervals. RESULTS: Treatment response was recorded: CR=24.2%, PR=55.2%, SD=10.3%, and PD=10.3%. Seventy-nine percent responded favorably with 7 patients (24.2%) showing marked tumor bulk reductions. There were no treatment-related morbidities or mortalities. CONCLUSIONS: All 29 patients are alive with a median survival of 11 months as of this writing. Eighty percent report a significant improvement in quality of life. Targeted locoregional immunochemotherapy using the above drugs is a promising option for patients with far-advanced metastatic liver disease. PMID- 9951905 TI - GB virus C infection by blood transfusion during and following liver surgery. AB - BACKGROUND/AIMS: GB virus C has been associated with some cases of fulminant hepatitis and post-transfusion hepatitis. We examined transfusion-related infection with this virus. METHODOLOGY: Of 150 patients undergoing liver resection, 108 received a homologous blood transfusion. Serum samples before and after surgery were examined for GB virus C RNA by a nested polymerase chain reaction with reverse transcription. We also studied the post-operative course of patients infected with GB virus C by blood transfusion. RESULTS: Viral RNA was detected in sera taken after transfusion in 4 (4%) patients receiving homologous transfusions. Viral RNA was not detected after surgery in the 42 patients given autologous transfusions or not receiving homologous blood. Post-operative courses in the 4 infected patients were uneventful. CONCLUSIONS: As 4% of homologous transfusions resulted in GB virus C infection in our small surgical study, autologous transfusion is recommended when circumstances permit. PMID- 9951906 TI - Lipid parameters predicting liver function in patients with cirrhosis and after liver transplantation. AB - BACKGROUND/AIMS: The liver plays a central role in the production and metabolism of lipoproteins, regulating their synthesis and degradation. The protein content of the lipoproteins are the so-called apolipoproteins. Some of the apolipoproteins serve as cofactors for enzymatic reactions, as ligands for interaction with specific receptors, and as structural proteins. Apolipoprotein B (apoB) is the primary structural component of the atherogenic low density lipoprotein (LDL) particles and has a specific binding region for interacting with the LDL-receptor. In contrast, apolipoprotein A-I (apoA-I) represents the primary protein content of the high density lipoprotein (HDL) particles, which interacts with the putative HDL-receptor, and stimulates the enzymatic reaction of lecithin-cholesterol acyltransferase (LCAT) resulting in esterified cholesterol, which is the essential step in the process of reverse cholesterol transport. METHODOLOGY: We studied lipid parameters in arterial and hepatic venous serum samples from 52 patients with cirrhosis and from 16 patients in the clinically stable long-term course after liver transplantation. Splanchnic blood flow was measured (indocyanine-green steady-state infusion) and hepatic extraction/production rates were calculated. To assess the influence of the clinical stage of established cirrhosis, the quantitated parameters were statistically analyzed. RESULTS: In cirrhosis, apolipoprotein A-I levels are decreased depending on the clinical stage (p<0.01). This parameter showed excellent correlations to liver function tests. Triglycerides (TG) (p<0.05) and cholesterol (Chol) (p<0.05) were reduced as well, whereas apolipoprotein B levels did not change. In cirrhosis, hepatic production of both cholesterol and triglycerides were decreased (p<0.05 each), as well as hepatic extraction of free fatty acids (FFA) (p<0.01). Except for cholestatic liver disease with raised serum cholesterol (p<0.05) and apolipoprotein B levels (p<0.001), the etiology of cirrhosis had no impact on the observed serum lipid alterations. CONCLUSIONS: The serum concentrations of the determined lipid parameters depend primarily on liver function. Decreased liver function was associated with reduced extraction of free fatty acids and reduced cholesterol and triglyceride synthesis. Liver transplantation restored the lipid abnormalities to normal. Finally, apolipoprotein A-I served as an excellent parameter for predicting liver function in the studied patients. PMID- 9951908 TI - Diagnosis and treatment of liver hydatid disease. AB - BACKGROUND/AIMS: Human echinococcosis is endemic in some areas of the world, including Mediterranean countries. The liver is the most frequent seat of echinococcosis, involved in about 70% of cases. Because there is still no effective medical therapy, surgery remains the treatment of choice. METHODOLOGY: Twenty-seven patients operated on for liver hydatid disease between 1990 and 1995 were analyzed and compared with results obtained from a study undertaken at our clinic between 1960 and 1988. RESULTS: The diagnosis was established by typical case history, clinical features and laboratory tests, of which imaging methods proved most informative. Radical procedures (total pericystectomy and liver resection) seem to be too aggressive for treatment. Marsupialization and drainage were mostly abandoned, because of high morbidity rates. CONCLUSIONS: Among surgical procedures used at our clinic, evacuation of the cyst with partial excision of the pericyst and omentoplasty resulted in the lowest morbidity and, thereupon, the shortest post-operative hospital stay and the best clinical results. PMID- 9951907 TI - Semiquantitative evaluation of hepatic fibrosis by measuring tissue hydroxyproline. AB - BACKGROUND/AIMS: It is important to evaluate the degree of hepatic fibrosis when diagnosing and treating hepatic cirrhosis. We focused on hydroxyproline, which is detected specifically in collagen, which plays a major role in hepatic fibrosis. The correlations between liver tissue hydroxyproline residue levels and the degree of hepatic fibrosis were examined in dogs with dimethylnitrosamine-induced fibrotic livers. METHODOLOGY: Dimethylnitrosamine was administered to dogs to establish experimental hepatic fibrosis. Paraffinized sections of liver specimens, stained with hematoxylin-eosin and azan, were examined and the degree of hepatic fibrosis was graded. About three-milligram samples of liver tissue were loaded onto a fully automated liquid chromatograph and the levels of hydroxyproline residues were measured. RESULTS: The liver tissue hydroxyproline appeared to reflect the degree of hepatic fibrosis. The liver tissue hydroxyproline levels and pathological hepatic fibrosis grades correlated significantly (p<0.05). CONCLUSIONS: Tissue hydroxyproline appears to be a more useful fibrosis marker, because hydroxyproline is influenced less by other factors. Furthermore, our results demonstrate that a very small amount of liver tissue (wet weight 3 mg) was enough to enable the levels of hydroxyproline residues to be measured by an automated amino acid analyzer (JLC-3000) and hepatic fibrosis is expressed as the numerical value by this analysis. PMID- 9951909 TI - Effect of tuftsin on human Kupffer cell. AB - BACKGROUND/AIMS: Kupffer cells are the most important category of reticuloendothelial cells which are critical for host defense in the liver. We investigated the effects of tuftsin (Thr-Lys-Pro-Arg) on human Kupffer cells. METHODOLOGY: Human Kupffer cells were obtained from the livers of patients with colon cancer. Phagocytosis assay was done by microscopic counting of the number of Kupffer cells that engulfed fluorescent particle(s), and the number of the particles engulfed per Kupffer cell when Kupffer cells were incubated with and without tuftsin. Effect of tuftsin on the release of tumor necrosis factor from Kupffer cells was also studied. RESULTS: Phagocytosis was enhanced significantly by tuftsin. The greatest effect on percentage of phagocytic cells was observed at 1.0 microg/ml of tuftsin. The mean number of particles engulfed per Kupffer cell was also increased with tuftsin 1.0 microg/ml. Tumor necrosis factor release was also significantly increased; the greatest effect was observed at 1.0 microg/ml of tuftsin. CONCLUSIONS: Tuftsin enhances phagocytic activity and tumor necrosis factor release of human Kupffer cells, which are advantageous for host defense against invading microorganisms and tumor cells. PMID- 9951910 TI - Risk factors influencing the outcome of portal and mesenteric vein thrombosis. AB - BACKGROUND/AIMS: This study analyzes risk factors that influence the course and outcome of portal and superior mesenteric vein thrombosis (PMVT). METHODOLOGY: We retrospectively reviewed 45 patients who were admitted to our institution over a 17-year period with a diagnosis of PMVT. Patients were classified according to three etiological groups, namely: cirrhosis (47%), pancreatitis (22%), and other causes (33%), with 1 patient belonging to two different groups. RESULTS: Over the course of the disease, rupture of gastric or esophageal varices was more frequent (p<0.005) in cirrhotics (75%) than non-cirrhotics (17%). Sclerotherapy was always the first treatment for variceal bleeding, with a success rate of 73% but a rate of recurrence of 56%. Surgical procedures were performed on 22% of patients. Actuarial survival was 43% at 5 years, but survival was significantly increased for idiopathic cases (p=0.005) and decreased in the presence of cirrhosis (p<0.001), malignancy (p<0.0001) or hematemesis (p<0.005). Gastrointestinal bleeding and terminal malignancies were responsible for 50% of deaths. CONCLUSIONS: Cirrhotic patients experience a detrimental outcome with an increased risk of gastrointestinal bleeding, which is the first cause of mortality in PMVT. Non-cirrhotic patients, especially idiopathic cases, enjoy a longer survival rate and seldom bleed, which allows for the use of anticoagulative therapy. PMID- 9951911 TI - Phase II clinical trial of combined natural interferon-beta plus recombinant interferon-gamma treatment of chronic hepatitis B. AB - BACKGROUND/AIMS: Alpha-interferon (IFN-alpha) is an effective treatment for chronic hepatitis B but only 25-40% of patients will profit from a long-term beneficial response to the currently recommended schedule of 3-6 MU given 3 times a week for 6 months. Clinical trials are therefore needed to investigate alternative modifications of interferon therapy, including combinations of different antivirals or immune modulators in order to improve the therapeutic approach to chronic hepatitis B infection. In a phase II trial we evaluated whether a combination of natural interferon-beta (nIFN-beta) with strong antiviral activity plus recombinant interferon-gamma (rIFN-gamma) with a predominantly immunomodulatory activity is able to increase the response rate compared to historical controls treated with IFN-alpha in a conventional regimen. METHODOLOGY: Forty patients with chronic hepatitis B were included in this trial of combined interferon therapy at a dosage of 6 MU nIFN-beta during week 1 followed by 3 MU for weeks 2-4 plus rIFN-gamma at a daily subcutaneous (s.c.) injection of 150 microg during the entire 4 weeks of the treatment period. Patients entered the trial on the basis of the following criteria: hepatitis B surface antigen (HBsAG), HBeAG and HBV-DNA positive for at least 6 months, HDV, EBV, CMV, anti-HIV negative, and chronic hepatitis proven on biopsy taken within 4 weeks of entry as well as 6 and/or 12 months after interferon therapy. The final diagnosis and classification of chronic hepatitis has been based on guidelines according to a revised classification of chronic hepatitis (Desmet 1994). The post-treatment follow-up was 12 months. RESULTS: The combined interferon therapy achieved complete responses with seroconversion from HBeAG to anti-HBe and a negative HBV-DNA (dot blot) test, as well as normalization of ALT activity in 15 patients, and partial response with negativation of HBV-DNA concomitant to a decrease in aminotransferase activity to near normal levels in 6 patients. Nineteen patients showed no response to viral markers but showed relief of clinical symptoms as well as pronounced decrease of serumtransaminase activity. Grading of liver biopsies demonstrated an improvement of histologic parameters after the interferon regimen in half of the evaluable patients (n=22). Histological response has been quantified by a reduction in the score of histological activity (HAI-index) from 12.6 before to 7.6 after interferon therapy, and in the inflammation and cellular degeneration score (ICD) from 9.9 to 5.2. Histological response, however, failed to show a consistent correlation with serologic response. This medium-dose combination of interferon-beta and interferon-gamma was tolerated very well by the patients, this good tolerability being explained by tachyphylaxis in response to daily interferon doses. No serious side effects or decompensation of liver function were observed during the 4-week period of therapy or the follow-up, despite the special clinical situation where 60% of the patients included in the study presented with histologically proven cirrhosis (35% of them with clinical manifestation of mildly decompensated cirrhosis). CONCLUSIONS: This short-term regimen of combined nIFN-beta + rIFN gamma therapy in patients with chronic hepatitis B proved to be equieffective to long-term treatment with interferon-alpha and combines high clinical tolerability with good practicability, as it can be administered on an in-patient basis, ensuring close patient monitoring. PMID- 9951912 TI - In vivo effect of granulocyte-macrophage colony-stimulating factor and interferon combination on monocyte-macrophage and T-lymphocyte functions in chronic hepatitis B leukocytopenic patients. AB - BACKGROUND/AIMS: Both rhGM-CSF and IFN-gamma have antiviral and immunoregulatory effects. Furthermore, GM-CSF has the advantage of increasing WBC in leukocytopenic patients. METHODOLOGY: We investigated a) the antiviral effects of rhGM-CSF and INF-alpha combination treatment in 12 chronic hepatitis B patients with leukocytopenia as a result or not of previous interferon therapy, b) the in vivo effects of these agents on monocyte-macrophage and T-lymphocyte functions and, c) their correlation to HBV infection outcome. RESULTS: Combination therapy caused a significant fall in HBV-DNA levels (p<0.0002), accompanied by significant reductions in transaminase levels and in histological activity index (p<0.0001, in each case). In parallel, rhGM-CSF induced a 2.7- to 5-fold weekly increment in WBC. Moreover, treatment caused a significant increase in all monocyte-macrophage parameters (p<0.0001 for random, directed migration and phagocytosis index) and in peripheral blood lymphocyte parameters (p<0.0001 for IL-2r and HLA-DR expression) studied. A similar picture was also obtained from cytokine levels (IL-2 and GM-CSF) in the supernatants from PHA-cultured T lymphocytes (p<0.0003, <0.001, respectively). CONCLUSIONS: The combined therapy achieves the initial treatment aim of increasing WBC and exerting an antiviral effect. In addition, the observed changes in immunological parameters probably reflect a Th1 pattern of immune response that could be responsible for the fate of HBV infection. Finally, cytokine levels (IL-2 and GM-CSF) in the supernatants might serve to monitor viral activity and outcome of the HBV infection. PMID- 9951913 TI - Evaluation of contrast echocardiography and lung perfusion scan in detecting intrapulmonary vascular dilatation in normoxemic patients with early liver cirrhosis. AB - BACKGROUND/AIMS: Intrapulmonary vascular dilatations (IPVD) are extrahepatic complications occurring in liver transplant candidates, that can result in severe hypoxemia. The aim of this study was to compare the use of two diagnostic modalities, contrast echocardiography and lung perfusion scan, in detecting IPVD in normoxemic patients with early liver cirrhosis. METHODOLOGY: Fifty-six consecutive outpatients with biopsy-proven cirrhosis had contrast echocardiography, a lung perfusion scan, pulmonary function tests, and arterial blood gas estimations. All patients were grade A or B according to the Child-Pugh classification. Patients with chronic intrinsic lung disease, heart failure or malignancy were excluded from the study. RESULTS: All patients had normal arterial blood-gas analyses. Eight out of 56 patients (14.3%) had a positive contrast echocardiogram, all with a decreased diffusion capacity (DLCO < 75% of the predicted value). An isolated DLCO impairment was observed in 40% of the patients with normal spirometry. None of the patients with echocardiography proven IPVD had a positive lung perfusion scan (p<0.005). CONCLUSIONS: In normoxemic cirrhotic patients, subclinical pulmonary vasodilatation and gas exchange abnormalities can occur. Contrast-enhanced echocardiography is the most valuable screening test in detecting IPVD in the early stages of hepatic insufficiency. PMID- 9951915 TI - Effects of transjugular intrahepatic portosystemic shunt (TIPS) on quantitative liver function tests. AB - BACKGROUND/AIMS: The transjugular intrahepatic portosystemic stent-shunt (TIPS) has been established as a new effective treatment for portal hypertension in advanced liver disease. Impairment of liver function due to reduced portal venous perfusion is considered to be a major risk of TIPS, and the shunt leads to an increase in the incidence of hepatic encephalopathy (HE). Known complications, like the increase in the incidence of HE or TIPS stenosis, are diagnosed either clinically or by doppler ultrasound. It is not practicable to use quantitative liver function tests in the diagnostic work-up of HE, and medical or interventional therapy can be established after clinical diagnosis. Still, information is limited about the influence of TIPS on quantitative liver function tests in patients with liver cirrhosis. Therefore, the aim of this prospective study was to assess the effects of TIPS on various liver function tests. METHODOLOGY: Fifteen patients with liver cirrhosis, a hepatopetal portal flow before TIPS, and an uncomplicated course without stenosis after elective TIPS were analysed. Liver function was quantitatively measured using the [14C]aminopyrine breath test (ABT), considered to be independent of hepatic blood flow, the monoethylglycinexylidide test (MEGX), believed to be largely dependent on hepatic blood flow, serum bilirubin, serum albumin, and prothrombin time. Measurements were performed before, 1, 3 and 6 months after TIPS. RESULTS: TIPS decreased the portal venous pressure gradient from 31.0+/-2.0 cm (SEM) H2O to 16.9+/-1.8 cm H2O (p<0.01). One, 3 and 6 months after TIPS there was no significant deterioration of liver function as assessed by ABT, MEGX or serum bilirubin, serum albumin, and prothrombin time compared to baseline values before TIPS. ABT and MEGX were significantly correlated before TIPS (r=0.72; p<0.01) and after TIPS (r=0.76; p<0.05). CONCLUSIONS: These data show no significant deterioration of microsomal liver function as measured by the quantitative liver function tests ABT and MEGX over a period of 6 months after elective TIPS. In particular, there was no significant reduction of the MEGX-test considered to depend predominantly on hepatic blood flow. Thus, there is no need for the quantitative liver function tests ABT and MEGX in the routine management of patients following the TIPS procedure. PMID- 9951914 TI - Escalating interferon-alpha-2b dose for patients with chronic hepatitis C. AB - BACKGROUND/AIMS: We examined the effectiveness of escalating the dose of interferon-alpha-2b in subjects with chronic hepatitis C who did not respond to usual treatment with 3,000,000 units 3 times a week. METHODOLOGY: Treatment was started with 3,000,000 units of interferon-alpha-2b 3 times a week. If serum alanine aminotransferase activity was not normal at 12 weeks, the dose was increased to 3,000,000 units daily. If serum alanine aminotransferase activity was not normal after 12 weeks, the dose was increased to 5,000,000 units daily. RESULTS: Fifty-one subjects started treatment. Twenty-nine subjects had their dose increased to 3,000,000 units daily and only 1 responded (3%, 95% confidence interval 0-10.9%) while 41% (95% confidence interval 21.4-60.6%) had to discontinue treatment at this dose because of adverse events or intolerance. Of 14 subjects who had their dose increased to 5,000,000 units daily, none (95% confidence interval 0-3.6%) responded, while 43% (95% confidence interval 13.5 72.5%) had to discontinue treatment. CONCLUSIONS: Escalating doses of interferon alpha-2b are not effective and are associated with increased toxicity and intolerance in patients with chronic hepatitis who do not respond to initial treatment with 3,000,000 units 2 times a week. PMID- 9951916 TI - The effect of interferon and desferrioxamine on serum ferritin and hepatic iron concentrations in chronic hepatitis B. AB - BACKGROUND/AIMS: Recent reports indicate that an individual's iron status might affect the response rate achieved with Interferon therapy for the treatment of chronic viral hepatitis. METHODOLOGY: Forty individuals, 29 men and 11 women, with chronic viral hepatitis B, who had elevated serum ferritin levels, were randomized to receive either Interferon (IFN) 5 MU TIW SQ for 6 months alone (n=21) or Interferon in combination with repetitive cycles of desferrioxamine infused at a dose of 80 mg/kg per cycle (n=19) over 3 consecutive days in an effort to reduce their metabolically active iron pool during the course of IFN treatment. These cycles were continued until a serum ferritin level of less than 250 ng/ml (normal values <220 ng/ml) was achieved. Additionally, all desferrioxamine treated subjects were placed on a low iron containing diet. An interferon response was defined as normalization of the serum ALT and seroconversion from eAg positive to eAb positive. All other responses were defined as failures. RESULTS: The mean ages of the subjects in the 2 groups were 39+/-6 and 38+/-5 years. The initial serum ALT levels were 150+/-27 and 151+/-13 IU/l. The hepatic iron concentrations were 916+/-29 and 896+/-15 microg/g/dry liver weight. The serum ferritin levels were 386+/-12 and 393+/-18 ng/ml. None of these values differed significantly between the 2 treatment groups. The desferrioxamine treated group consisted of 14 men and 5 women. This group experienced a reduction in their serum ferritin to a level of 237+/-13 ng/ml as a result of the desferrioxamine treatment (p<0.05). Additionally, a reduction in their hepatic iron concentration, to a level 766+/-29 microg/g/dry liver weight, occurred with treatment (p<0.05). Twelve of the 19 (63%) desferrioxamine-treated subjects and 8 of the 21 (38%) control subjects experienced a normalization of their serum ALT levels with treatment (p<0.05). Thirteen of 19 (68%) of the desferrioxamine-treated subjects but only 8 of 21 (38%) of the IFN alone treated group seroconverted to anti-e positive (p<0.05). Moreover, a greater improvement in the hepatic histologic score and rate of HBV-DNA loss occurred in the desferrioxamine-treated group. CONCLUSIONS: Based upon these data, it can be concluded that desferrioxamine infusion to achieve a normal serum ferritin level enhances the likelihood of an individual with chronic hepatitis B responding to IFN therapy. The precise mechanism responsible for this phenomenon is not clear, but would appear to be due to a reduction in the hepatic free iron pool as reflected by sequential changes in the serum ferritin and hepatic iron concentrations. PMID- 9951917 TI - Chronic liver diseases for the risk of hepatocellular carcinoma: a case-control study in Japan. Etiologic association of alcohol consumption, cigarette smoking and the development of chronic liver diseases. AB - BACKGROUND/AIMS: A great number of hepatocellular carcinoma (HCC) develop from chronic liver disease. Among a total of 23,000 deaths of HCC in 1988 in Japan, 82% had positive antibodies against HBV and/or HCV. In the present study we investigated the etiological factors involved in this process, employing patients with chronic hepatitis as controls. METHODOLOGY: In this study, alcohol consumption and cigarette smoking were investigated in 104 male patients with HCC which developed from chronic liver disease and 104 male controls with chronic liver disease without HCC (one for each case) matched for age. RESULTS: When compared with non-drinkers and non-smokers, the relative risk (RR) for developing HCC rose to 17.9 among those with both drinking and smoking habits. The risk was greater than for those in whom either habit existed alone. The RR decreased among ex-smokers who were non-drinkers or ex-drinkers, but it was still as high as 9.4. For current smokers, even if they were non- or ex-drinkers, the RR was 15.4. CONCLUSIONS: Drinking and the cigarette smoking were both risk factors, but the existence of synergism between them was also suggested. Therefore, patients with chronic liver disease should be thoroughly counseled to refrain from both drinking and smoking. PMID- 9951919 TI - Choledocholithiasis at the hepatic confluence mimicking a hilar cholangiocarcinoma. AB - Adenocarcinomas of the bifurcation of the hepatic ducts (Klatskin tumors) are a relatively rare cause of obstructive jaundice. Differential diagnosis includes other neoplastic lesions, sclerosing cholangitis, Mirizzi's syndrome and benign strictures. We present a 46 year-old white female with a 2 month history of epigastric pain and progressive jaundice. Endoscopic retrograde cholangiopancreaticography (ERCP) revealed a filiform stenosis of the right hepatic duct and an obstructed left hepatic duct, an image strongly suggestive of a Klatskin tumor. The correct diagnosis was achieved, however, by percutaneous transhepatic cholangiography (PTC), which disclosed a gallstone at the common hepatic duct bifurcation and multiple small concrements in the left hepatic duct. After endoscopic removal of the gallstones in the biliary tree and laparoscopic cholecystectomy, the patient was discharged on the third post-operative day. Protuberant tumors and round biliary stones may be confused at ERCP. PMID- 9951918 TI - Laparoscopic liver resection compared with conventional partial hepatectomy--a prospective analysis. AB - BACKGROUND/AIMS: Tumor size and location are the major influences on the practicality of a laparoscopic operation. Visual control of the operating field is important for isolation and ligation of blood vessels and bile ducts after selective liver dissection by suitable techniques such as the water-jet dissector. METHODOLOGY: We carried out laparoscopic liver resections with the Jet Cutter in 17 patients. The results were compared to a control group of 17 closely matched patients undergoing conventional hepatic resection during the period of the study. In 1 patient, conversion of laparoscopic to an open operation was required. RESULTS: Early in our learning curve, the duration of operation and time for resection were significantly longer in the laparoscopic group. Following laparoscopic operation, patients were discharged from the hospital after a mean of 7.8+/-8.2 days; patients having undergone conventional operation were discharged after a mean of 11.6+/-12.8 days. CONCLUSIONS: Laparoscopic liver resection is technically feasible, but, at present, careful patient selection is required. PMID- 9951921 TI - A case of non A, non B, non C hepatitis that relapsed into fulminant hepatic failure. AB - We describe a 12 year-old patient that relapsed into fulminant non A, non B, non C (NANBNC) hepatitis 10 weeks post-clinical recovery. A complete clinical and pathological evaluation, including an ultra-structural examination of a liver biopsy was consistent with the diagnosis of NANBNC hepatitis. The patient relapsed into hepatic failure and required transplantation. NANBNC hepatitis may have a relapsing form that can lead to hepatic failure requiring transplantation. Consultants in hepatology should have a high degree of clinical awareness and maintain prolonged patient follow-up. PMID- 9951920 TI - Adult celiac disease and primary sclerosing cholangitis: two case reports. AB - The association of primary sclerosing cholangitis and celiac disease is uncommon. Herein, we report on 2 different cases which developed this association. Case 1 was a 59 year-old female who firstly complained of symptoms of cholestasis. The diagnosis of primary cholangitis was made on liver biopsy, and the endoscopic retrograde cholangiopancreatography (ERCP) showed narrowing and irregularity of the extra- and intrahepatic bile ducts. The results were positive for antiendomysial antibodies and the jejunal biopsy confirmed the coexistence of celiac disease, which was asymptomatic until that moment. The gluten-free diet ameliorated the index of cholestasis. Case 2 was an old man suffering from undiagnosed celiac disease for at least 5 years prior to admission at our Department. The diagnosis was based on the histological examination of a jejunal biopsy. The patient did not follow the gluten-free diet and was again admitted to our Department 6 years later with symptoms of cholestasis. The liver biopsy and ERCP confirmed the diagnosis of primary sclerosing cholangitis. PMID- 9951922 TI - Hepatocellular carcinoma in primary biliary cirrhosis: a case report and review of the Japanese literature. AB - We present a 66 year-old woman in the cirrhotic stage of primary biliary cirrhosis (PBC), who developed hepatocellular carcinoma (HCC). All serological tests for hepatitis B virus (HBV) and hepatitis C virus (HCV) were negative. We surveyed 16 reported cases (13 females and 3 males) of PBC associated with HCC in Japan. The presence of HCV RNA was determined by the polymerase chain reaction in all of the patients, 3 of whom (19%) were HCV RNA-positive. Although patients with PBC rarely develop HCC, it is suggested that HCV infection may play a minor role in the development of HCC in Japanese patients with PBC. PMID- 9951923 TI - Asymptomatic intrahepatic choledochal cyst associated with chronic active hepatitis C. AB - A rare case of asymptomatic congenital choledochal cyst (Todani Type V) associated with chronic active hepatitis C is reported. A 45 year-old man was admitted for work-up of localized cystic dilatation of the intrahepatic bile ducts after effective interferon treatment for chronic active hepatitis C. Radiologic examination revealed localized cystic dilatation of the intrahepatic bile ducts in the atrophic left lobe. A left hepatic lobectomy was performed because malignancy had not been excluded. Macroscopic examination of the resected specimen revealed cystic dilatation of the intrahepatic bile ducts. Histologically, there was no evidence of malignancy. Hepatic lobectomy is the treatment of choice for Type V cysts if the disease is confined to a single lobe. Choledochal cysts should be excised to eliminate the potential for cholangitis, lithiasis, and carcinoma. PMID- 9951924 TI - Clinical features, image analysis, and laparoscopic and histological liver findings in Budd-Chiari syndrome. AB - BACKGROUND/AIMS: Clinical manifestations and histological features of the liver in Budd-Chiari syndrome (BCS), with or without idiopathic membranous obstruction of the inferior vena cava (MOVC), vary according to whether BCS is acute, subacute or chronic. We clarified the diagnostic features in 6 patients with MOVC and in 1 without MOVC. METHODOLOGY: Five patients with subacute or chronic type BCS with MOVC complaining of epigastric pain, hematemesis and encephalopathy, and signs of portal hypertension or collateral circulation were seen. There was 1 asymptomatic patient with MOVC. One patient with acute type BCS without MOVC revealed hepatic and multi-organ failure. Liver function tests in BCS with MOVC were similar to those in liver cirrhosis, and laboratory data in acute type without MOVC were quite the same as those seen in fulminant hepatitis. Non invasive image analysis by US, CT and MRI showed thrombi and obstruction of the IVC, and extrahepatic vasculature or communication between hepatic veins and IVC. Vena cavography showed the length of obstruction in IVC and collateral circulation in the extrahepatic or intrahepatic veins. Liver biopsy demonstrated massive hemorrhagic necrosis in acute type without MOVC, and laparoscopy with liver biopsy in asymptomatic, subacute and chronic type with MOVC showed subcapsular hemorrhage, congestion, fibrosis, and cirrhotic features. CONCLUSIONS: The non-invasive image analysis was complementary to vena cavography, and liver biopsy with or without laparoscopy was essential not only for diagnosis of acute, subacute, and chronic BCS, but also for therapeutic decision-making. PMID- 9951925 TI - Transient spontaneous regression of hepatocellular carcinoma. AB - We report on 2 patients with liver cirrhosis and biopsy-proven hepatocellular carcinoma who underwent spontaneous regression. In 1 case the tumor became undetectable at ultrasonography, while, in the other, the liver lesions decreased in size and showed inner calcifications. In both patients, alpha-fetoprotein, which was high at first diagnosis, returned to normal values. After a tumor-free period of 4 years and 17 months, respectively, liver cancer reappeared and patients died from complications. We advance the hypothesis that tumor regression, when it occurs in cirrhotic patients, is always transient, with chronic liver disease being the oncogenic triggering factor. PMID- 9951926 TI - Chronic liver failure induced by long-term administration of tegafur: a case report. AB - A 55 year-old man was admitted with massive ascites. Although the laboratory data on admission were compatible with hepatic cirrhosis and remarkable esophageal varices were observed during endoscopy, the imaging findings such as computed tomography and ultrasonographic examination did not confirm hepatic cirrhosis. The patient had no history of alcohol abuse, blood transfusions or acute hepatitis. Serological markers related to viral and autoimmune hepatitis were all negative. Seven years ago, the patient had undergone an operation for colon cancer and has been taking tegafur since then for a total of 55 months. Tegafur was suspected as the causative agent for the liver dysfunction of this patient and the administration of tegafur was stopped. His laboratory data improved gradually and the ascites vanished. The first liver biopsy performed 6 months after discontinuation of tegafur still revealed chronic active hepatitis. However, at the liver biopsy performed 18 months after withdrawal of tegafur, inflammatory activity had subsided and the third liver biopsy, performed 34 months thereafter, revealed further improvement of the pathological changes that had occurred in the liver. We therefore conclude that the administration of tegafur may have caused chronic active liver injury with portal hypertension manifested as ascites and esophageal varices. PMID- 9951928 TI - Pancreatic duct patency after pancreaticogastrostomy: long-term follow-up study. AB - BACKGROUND/AIMS: To clarify whether the pancreatic duct remains patent during long-term follow-up of patients after pancreaticogastrostomy. In a previous study of pancreaticogastrostomy with post-operative follow up for 3 years after surgery, we found that the orifice of the pancreatic duct was difficult to detect in some patients because of swelling of the gastric mucosa. Previous studies have not examined pancreatic duct patency during long-term follow-up. METHODOLOGY: Between July 1985 and August 1989, 20 patients underwent a pylorus-preserving pancreaticoduodenectomy with reconstruction by pancreaticogastrostomy. Five of these patients were followed up post-operatively for more than 9 years to determine the patency of the pancreatic duct. All pancreatic anastomoses were performed by the telescopic method. RESULTS: All 5 patients were female, with a mean age of 65.4 years (range: 54-75). Median post-operative follow-up was 10.8 years (range: 9-12). The indications for surgery were carcinoma of the ampulla of Vater in 4 patients and chronic pancreatitis in 1 patient. Pancreatic duct patency was confirmed in 4 patients by gastroscopy and pancreatography. However, the anastomotic orifice could not be detected in the remaining patient because of complete coverage by the gastric mucosa. In this patient, pancreatic exocrine and endocrine function deteriorated with dilation of the distal pancreatic duct. The patient underwent a second operation involving dissociation of the pancreatico gastric anastomosis and resection of about 1 cm of the fibrous, proximal portion of the pancreas. Reconstruction was performed with a Roux-en-Y pancreaticojejunostomy and a mucosa-to-mucosa anastomosis. CONCLUSIONS: Although pancreaticogastrostomy has been applied as a safe and straightforward method for reconstruction after pancreaticoduodenectomy, anastomotic stenosis is a potential late complication of this approach. PMID- 9951927 TI - A prospective randomized study using adjuvant locoregional chemoimmunotherapy in combination with surgery for pancreatic carcinoma. AB - BACKGROUND/AIMS: A prospective randomized clinical trial combining adjuvant locoregional chemoimmunotherapy for pancreatic carcinoma in 512 patients was conducted from September 1991 to September 1998 at Athens Medical Center. METHODOLOGY: All patients were randomly assigned to (A) Resective Surgery (n=274), and (B) Palliative Surgery (n=238) groups. Each group was further subdivided into: (1) surgery alone, and (2) surgery plus 1-day bolus chemotherapy (Gemcitabine 1 gm/m2, Carboplatin 200 mg/m2 and Mitoxantrone 0.2 g/kg bw suspended in 10 ml of Lipiodol and 2 ml of 58% urografin), and immunotherapy (1 ml IL-2 and 0.5 ml gamma-IFN suspended in 5 ml of Lipiodol and 1 ml of 58% urografin) followed by a 5-day course of transplenic and another 5-day course of transtumoral immunotherapy using the same agents. This was repeated at 2-month intervals during the first post-operative year and every 3 months thereafter. RESULTS: Significant reduction in patient symptomatology and improvements in post treatment quality of life were noted in patients receiving adjuvant chemoimmunotherapy. Moreover, the mean survival rate significantly improved in patients receiving the adjuvant treatment, both for the resective (32 months) and the palliative (16 months) groups. CONCLUSIONS: The treatment regimen employed was well tolerated and did not contribute to any clinical deterioration. Adjuvant targeted locoregional chemoimmunotherapy is therefore a promising avenue in the management of patients with pancreatic carcinoma. PMID- 9951929 TI - Para-aortic lymph node metastasis in carcinoma of the distal bile duct. AB - BACKGROUND/AIMS: Lymph node dissection plays an important role in radical surgery for pancreaticoduodenal carcinomas. The aim of this study was to identify the critical areas of lymph node dissection in carcinoma of the distal bile duct. METHODOLOGY: Between January 1995 and December 1996, 20 consecutive patients with distal bile duct cancer underwent pancreaticoduodenectomy with extended lymph node dissection (including the para-aortic nodes). Histopathologic findings were examined with special reference to lymph node metastasis. RESULTS: Histological evidence of lymph node metastasis was found in 11 patients (55%). The areas with frequent metastases were the posterior pancreaticoduodenal lymph nodes (35%), and the nodes around the hepatoduodenal ligament (35%) and around the common hepatic artery (30%). Para-aortic lymph node involvement was identified in 5 patients (25%). Most of these existed in the inter-aorticocaval space. Pancreatic parenchymal invasion was present in 10 patients. Half of the patients with pancreatic invasion had para-aortic nodal involvement. Para-aortic lymph node metastasis was significantly associated with pancreatic parenchymal invasion (p<0.05). CONCLUSIONS: In carcinoma of the distal bile duct with pancreatic parenchymal invasion, extended lymph node dissection (including para-aortic nodes) should be undertaken because of the relatively high incidence of metastasis. PMID- 9951930 TI - Clinical analysis of inflammatory masses of the pancreatic head region. AB - BACKGROUND/AIMS: Inflammatory masses of the pancreatic head are a dilemma for surgeons, especially when the differences between these lesions and pancreatic head carcinoma are not so clear. The surgical management of these inflammatory benign lesions is also a topic with conflicting opinions. A clinical analysis was performed in an attempt to differentiate between these lesions and malignancy. The results of our observatory strategy of these lesions are also presented. METHODOLOGY: From 1992 to 1994, 73 patients with ultrasonographically (US) or computed tomographically (CT) heterogenous pancreatic head lesions were diagnosed at the Department of Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan. Forty nine of these lesions were neoplastic (Group I), but the remaining 24 patients had inflammatory non-neoplastic lesions (pancreatic inflammatory masses, IPM, Group II), which were diagnosed during laparotomy by core needle biopsy. Surgery and outcome were reviewed. Ten of the 24 patients in group II received biopsy only, and the remaining 14 patients received bypass procedures. At follow-up of at least 16 months of the surviving patients (n=21), only 9.5% were with residual lesions. All cases in group II revealed shrinkage of masses. We focused on the clinical features, hematology, biochemistry, image study, serum CEA and CA 19-9, and compared these variances between the 2 groups. RESULTS: Three clinical features were statistically different between groups I and II: mean age at presentation of disease (group I vs II = 53.3 vs 65.1), the tendency of a past history of alcoholism (Group II), and presence of abdominal pain (Group II). Group II also showed a higher level of serum alkaline phosphatase and a lower level of total bilirubin as well as a lower level of CA19-9. These inflammatory masses could not be distinguished from the true neoplasms pre-operatively on endoscopic appearance, US, or CT. CONCLUSIONS: Pre-operative differentiation between these pancreatic lesions may be difficult but laparotomy and core needle biopsy remain safe and reliable procedures. Our short-term follow-up justified the bypass surgery and that observatory strategy is enough for those patients with pancreatic head inflammatory masses. PMID- 9951931 TI - Pre-operative predictors of short-term survival after pancreatic cancer resection. AB - BACKGROUND/AIMS: The aim of the present study is to investigate the pre-operative factors that affect short-term survival after pancreatic cancer resection and to evaluate their prognostic value. METHODOLOGY: Fifty-nine patients with ductal adenocarcinoma of the pancreas operated on in the Second Department of Surgery, Hokkaido University Hospital between 1989 and 1996 were reviewed. RESULTS: The patients had a mean age of 62.6 years. The difference of survival between patients aged 62 years or younger and older patients was significant (p=0.0053). Primary tumor size was evaluated with enhanced CT examination; 36 patients had tumors larger than 3 cm in diameter. The 1-year survival rate of patients with tumors 3 cm or less in diameter was significantly better than that of patients with primary tumors greater than 3 cm in diameter (p=0.0258). Analysis of carcinoembryonic antigen (CEA) showed a significant difference in 1-year survival rates between patients with a pre-operative value below twice the diagnostic cutoff level (cutoff index; C.I.) and patients with a value above this level (p=0.0006). The 1-year survival rate for the subset of younger patients (= or < 62 years) with smaller tumors (3 cm or less) and a lower pre-operative serum CEA level (= or < two times of C.I.), was 72.7% (n=11). Multivariate analysis indicated that age and the pre-operative serum CEA level were both independent prognostic factors of 1-year survival (p=0.0077, and 0.003, respectively), although the statistical significance of tumor size was weak (p=0.107). CONCLUSIONS: It was suggested that age and serum CEA level were independent prognostic factors of short-term survival after pancreatic cancer resection. PMID- 9951932 TI - Lessons learned from a complicated case of cephalic obstructive chronic pancreatitis. AB - The authors report the complex case of a 51 year-old man admitted to his local hospital for gallbladder and common bile duct lithiasis, 1 year before admission to our hospital. There, he was treated by cholecystectomy and transduodenal biliary sphincteroplasty. He was readmitted after 3 months because of a painful episode and was discharged with the diagnosis of "relapsing acute pancreatitis in chronic pancreatitis." At our hospital, he underwent laparotomy and revision of the previous transduodenal biliary sphincteroplasty. Pancreatic sphincteroplasty and septectomy were also performed. The night after surgery, the patient suffered from acute post-operative pancreatitis complicated by severe hemorrhage due to erosion of the superior pancreaticoduodenal arteries, treated with gastroduodenal artery embolization by tungsten coils. Three months later, the patient suffered from another acute episode. An endoscopic retrograde colangio pancreatography (ERCP) showed the complete patency of the sphincteroplasties but clearly identified the persistence of a severe cephalic stricture. Therefore, the patient was readmitted to our hospital and underwent another laparotomy. A pylorus preserving pancreaticoduodenectomy (PPPD) was performed. The post-operative course was uneventful and at 14 months follow-up the patient was in good health. The discussion focuses on the surgical treatment of chronic pancreatitis with cephalic Wirsung duct stenosis, stressing the increasing role of PPPD as a first choice option. PMID- 9951933 TI - Ductectatic mucinous cystadenocarcinoma of the pancreas: a rare variant. AB - A rare case of the ductectatic variant of mucinous pancreatic cystadenocarcinoma in a 64 year-old man, presenting with painless obstructive jaundice, is reported. CT scan revealed a multicystic lesion of the pancreatic head, which caused biliary obstruction. Endoscopic retrograde pancreatography (ERP) revealed the characteristic grapelike cluster pattern of pancreatic ductectatic neoplasms. Pancreaticoduodenectomy was then successfully performed. Pancreatic ductectatic mucinous cystadenocarcinoma is a rare entity, presenting, usually, with obstructive pancreatitis, and is histologically indistinguishable from the classic malignant mucinous cystic neoplasm. ERP is the diagnostic method of choice and should be performed in any case of susceptible pancreatic lesions. PMID- 9951934 TI - A case of solitary metastatic pancreatic cancer from rectal carcinoma: a case report. AB - A 79 year-old male who had undergone resection of the rectum for rectal cancer was shown to have metastasis to the pancreas 11 years after surgery. The metastatic lesion was located at the tail and body of the pancreas, and was resected with distal pancreatectomy. The same patient also had metastasis to the lung 8 years after initial rectal surgery. Therefore, the course of metastasis to the pancreas was suggested to be from the metastatic lung tumor to the pancreas by hematogenous spread. The patient was considered disease-free 8 months after the pancreatectomy. Recent advances in the technology of diagnostic imaging have facilitated the selection of surgical therapy for metastasis to the pancreas in rectal cancer patients after follow-up by imaging diagnosis. PMID- 9951935 TI - Benign retroperitoneal schwannoma mimicking a pancreatic cystic tumor: case report and literature review. AB - A rare case of benign retroperitoneal schwannoma mimicking a pancreatic cystic tumor is reported herein. The tumor mass, based on a computed tomography scan and an abdominal echo examination, was initially suspected to be a mucinous cystadenoma or cystadenocarcinoma of the pancreas. However, the surgical and pathohistological findings made a final diagnosis of benign pancreatic schwannoma. The patient is doing well at a 2-year follow-up. The tumor, 18x17x15 cm in size, represented the largest among reported pancreatic schwannomas. Furthermore, a comprehensive review of reported cases of pancreatic schwannoma was carried out to summarize corresponding findings, including benign or malignant forms, adherence to other tissues, cystic change of the tumor, as well as relation to von Recklinghausen's neurofibromatosis. PMID- 9951936 TI - Mucinous cystadenoma of the pancreas as a cause of acute pancreatitis. AB - Acute pancreatitis is only rarely the first presentation of a cystic neoplasm of the pancreas. Mucinous cystadenomas have not been reported to be a cause of acute pancreatitis; however, we present two cases of mucinous cystadenoma of the pancreas which have caused acute pancreatitis. Both patients (female) presented acute abdominal pain, with serum amylase elevation and ultrasound scan (US) and computed tomography (CT) evidence of moderate pancreatitis, which resolved with medical treatment; fluid collection in the distal pancreas had been misinterpreted as a pseudocyst. There was no history of alcohol abuse or gallstone disease. After distal pancreatectomy the diagnosis of mucinous cystadenoma was confirmed; in one case a large pseudocyst was associated with this diagnosis. Pre-operative differential diagnosis between inflammatory and neoplastic cysts is difficult, especially when the patient's first presentation is due to an episode of acute pancreatitis. A neoplastic cyst should be considered when acute pancreatitis attacks occur in non-alcoholic women, who do not have gallstone disease. PMID- 9951937 TI - Can clamping of splenic vessels prevent abrupt increase of portal vein pressure and migration of transplanted hepatocytes to the liver after intrasplenic hepatocyte transplantation? AB - BACKGROUND/AIMS: It is well known that hepatocyte transplantation can retain some proper functions, significantly improve the survival rate of rats with different models of acute fulminant hepatic failure, correct some congenital genetic disorders, and improve liver function in cirrhosis. Portal hypertension and hepatic embolization have been described following intrasplenic hepatocyte transplantation. We evaluated the effect of temporary occlusion of splenic vessels on changes in portal vein pressure and on distribution of transplanted hepatocytes after hepatocyte transplantation into the spleen in normal rats. METHODOLOGY: Liver cirrhosis has been induced in rats by 1% dimethylnitrosamine (Sigma, St. Louis, Mo) dissolved in normal saline at the dose of 10 ml of DMN/Kg, i.p., 3 consecutive days a week for 4 weeks. Donor hepatocytes were harvested by in situ ethylenediaminetetraacetic acid (EDTA) perfusion. Changes in portal vein pressures were monitored by a pressure monitor and distribution of transplanted hepatocytes was assayed by measurement of radioactivity of 51Cr-labeled transplanted hepatocytes according to clamping or non-clamping during intrasplenic hepatocyte transplantation. RESULTS: The changes in portal pressure remained significantly high 10 min after hepatocyte transplantation in the nonocclusion groups compared to the occlusion groups. However, the changes in portal vein pressures in cirrhotic rats returned to normal faster than in normal rats after cell transplantation in the nonocclusion groups. The distribution of 51Cr-labeled transplanted hepatocytes into the spleen significantly diminished radioactivity of the liver at 10 min, 2 hours, and 24 hours in the occlusion groups compared to the nonocclusion groups. Also, duration of clamping time of splenic vessels did not influence the initial distribution of transplanted hepatocytes at the time of intrasplenic hepatocyte injection. CONCLUSIONS: These results suggested that temporary occlusion of splenic vessels should be routinely used during intrasplenic hepatocyte transplantation. PMID- 9951938 TI - Reversible hypersplenism after splenopexy for wandering spleen. AB - Wandering spleen is a rare condition characterized by a normal spleen with extreme mobility associated with an elongated pedicle. The most common presentation is an acute surgical abdomen related to acute torsion. A case of wandering spleen complicated by symptomatic hypersplenism in a 29 year-old woman is presented. The hypersplenism was diagnosed after bleeding delivery, requiring blood transfusion. Wandering spleen was suspected after pre-operatively performed CT scan. The patient was successfully treated by splenopexy. This report illustrates that conservative surgical management may result in complete reversal of hematological symptoms. PMID- 9951939 TI - Helicobacter pylori-seronegative gastric carcinoma: a subset of gastric carcinoma with distinct clinicopathologic features. AB - BACKGROUND/AIMS: The frequent association of gastric atrophy and intestinal metaplasia in gastric cancer (GC) might preclude serologic detection of Helicobacter pylori (H. pylori) infection in GC. By using polymerase chain reaction (PCR) for detection, we would like to determine whether there exists a subset of genuinely H. pylori-negative GC patients, and whether they have distinct clinicopathologic features or not. METHODOLOGY: IgG antibodies against H. pylori were determined by ELISA in sera, and H. pylori DNA was detected by PCR in resected gastric specimens from 160 GC patients. Clinicopathologic characteristics were then compared among group A: seropositive, group B: seronegative but PCR-positive, and group C: seronegative and PCR-negative. RESULTS: Among 160 patients, 105 (65.6%) were classified as group A, 25 (15.6%) as group B, and 30 (18.8%) as group C. Group B patients were older and had more infiltrative tumor growth than group A. Group C had a significantly higher frequency of female predominance, and their cancers were of a more cardiac location and of the diffuse histologic subtype than those of groups A and B. CONCLUSIONS: A significant portion (15.6%) was negative to ELISA but positive to PCR, suggesting that older ages and infiltrative tumor growth might preclude serologic detection of H. pylori infection by impairing humoral responses. Although the majority (81.2%) has a strong association with H. pylori infection, an H. pylori-negative subset indeed exists and has distinct clinicopathologic features, supporting that causes other than H. pylori infection are involved in GC carcinogenesis. PMID- 9951941 TI - Magaldrate stimulates endogenous prostaglandin E2 synthesis in human gastric mucosa in vitro and in vivo. AB - BACKGROUND/AIMS: Prostaglandin E2 (PGE2) plays an important role in the inhibition of gastric acid production and exerts cytoprotective action. The in vitro and in vivo effect of magaldrate, an aluminum containing antacid, on PGE2 synthesis in the gastric mucosa was investigated. METHODOLOGY: In the first part of the study, magaldrate was added to a suspension of isolated gastric mucosal cells. In the second part, the antacid gel was applied to the gastric mucosa during gastroscopy and biopsies were taken from the same site 5 and 10 min later. RESULTS: The antacid significantly stimulated PGE2 release from the suspension of isolated gastric cells in vitro. The biopsies obtained after the application of magaldrate showed an increased PGE2 production compared to specimens obtained before. CONCLUSIONS: The data suggest that in addition to its neutralizing capacity as an antacid, magaldrate contributes to the cytoprotective activity of the mucosa by stimulating endogenous PGE2 synthesis. PMID- 9951940 TI - E-cadherin expression as a differentiation marker in gastric cancer. AB - BACKGROUND/AIMS: E-cadherin is a cell-cell adhesion molecule involved in tumor progression and metastasis. We evaluated the E-cadherin expression pattern in gastric cancer and investigated its relationship to histopathological features. METHODOLOGY: The expression of E-cadherin was evaluated in 83 formalin-fixed, paraffin-embedded specimens of gastric cancer by immunohistochemistry. RESULTS: In benign gastric mucosa, E-cadherin was expressed uniformly at the cell membrane. Abnormal E-cadherin expression with loss of membranous localization was found in 55 (56%) cancer specimens. Aberrant E-cadherin expression was found more often in diffuse (96%) and mixed type tumors (91%) than in intestinal type tumors (47%) (p=0.0001). A significantly higher proportion of signet-ring (84%) and undifferentiated tumors (87%) showed abnormal E-cadherin expression compared with adenocarcinomas with glandular morphology (57%) (p=0.01). There was a significant correlation between abnormal E-cadherin expression and degree of differentiation (p=0.0001), local tumor extent (p=0.002), and the presence of lymph node metastases (p=0.04). CONCLUSIONS: Loss of normal E-cadherin expression may serve as a differentiation marker in gastric cancer. PMID- 9951943 TI - 24-hr measurement of gastric mucosal perfusion in conscious humans. AB - BACKGROUND/AIMS: Gastric mucosal blood flow estimation in humans is obtained through an endoscope and the time of measurement lasts only a few minutes. Thinking that long-term monitoring of mucosal perfusion would be a significant contribution to the study of gastric physiology, we registered gastric mucosal blood flow continuously for 24 hours, using single fiber laser-Doppler technology. METHODOLOGY: The study was undertaken in 16 healthy subjects (8 of them had their gastric acidity inhibited with a proton pump inhibitor) and in 8 patients with an endoscopically proven, active duodenal ulcer. A 140 cm-long single fiber laser-Doppler microprobe was positioned through a gastrointestinal tube in the middle of the gastric corpus and the mucosal microcirculation was monitored from 14.00 h until 13.59 h the following day. Data were stored and processed to evaluate the probable circadian rhythms, using maximum entropy spectrum analysis. RESULTS: We found that the daily variations of gastric mucosal perfusion follow a circadian rhythm. The respective patterns with maximum and minimum values were: healthy controls, maximum at 02.00, 10.00, 18.00 h and minimum at 5.30, 14.00 and 22.00 h. Healthy controls treated by a proton pump inhibitor, maximum at 02.00, 07.00, 18.00 h and minimum at 04.00, 12.00 and 22.00 h. Ulcer patients, maximum 07.00 and 21.00 h and minimum at 17.00 and 24.00 h. CONCLUSIONS: It is concluded that long-term measurement of gastric mucosal blood flow in conscious humans is feasible and that this factor of gastric physiology follows a concrete circadian rhythm, which is not particularly influenced by acid inhibition, but is completely distorted in ulcer patients. PMID- 9951942 TI - Laparoscopic gastric banding for morbid obesity with expanded PTFE: technique and early results in the first 100 consecutive cases. AB - BACKGROUND/AIMS: Surgery is the only effective treatment for the truly morbidly obese patient. Gastric banding was demonstrated to be a safe, effective, and easily reversible technique in the open surgical approach. METHODOLOGY: A five puncture technique, developed by the authors, for laparoscopic gastric banding utilizing an expanded polytetrafluoroethylene (ePTFE) band is fully described and discussed. This technique was utilized in 100 consecutive patients operated on between October 1995 and November 1996. RESULTS: We recorded no mortality, no cases of conversion, a 1% rate of major complications, a low minor morbidity rate (10%), and an acceptable length of operative time (106+/-8 minutes). This was significantly related to body weight, B.M.I. and % of I.B.W. being longer in more obese patients, but not to the experience of the surgical team. Weight loss (35.0+/-5.1 kg), percentage of excess weight lost (55.3+/-5.3%), percentage of ideal body weight achieved (149.1+/-8.4%), and body mass index (33.8+/-2.0) were all significantly improved at 3, 6, 9 and 12-months follow-up. CONCLUSIONS: Early results of this series are promising, showing low morbidity and a rate of weight loss comparable to that achievable by means of open gastric banding or vertical banded gastroplasty. Any statement about long-term results deserves a longer follow-up. PMID- 9951944 TI - Serum human hepatocyte growth factor (hHGF) is elevated in patients with metastatic gastric carcinoma. AB - BACKGROUND/AIMS: Hepatocyte growth factor (HGF) is a stromally derived protein growth factor that modulates epithelial cell proliferation and motility. HGF may therefore be involved in tumor progression. METHODOLOGY: We measured the immunoreactive (ir)-HGF concentration in the sera of 56 patients with human gastric carcinoma, using an enzyme-linked immunosorbent assay and evaluated its association with clinical and histopathologic factors. Clinical stages were classified in accordance with The General Rules for TNM Classification (International Union Against Cancer). RESULTS: The serum hHGF concentrations from patients with gastric carcinoma significantly increased with increasing pathologic tumor grades. Also, there were significantly higher concentrations in patients with nodal metastasis compared to patients without metastasis. The serum hHGF concentrations in patients with liver metastasis were significantly higher than in patients without liver metastasis. CONCLUSIONS: These data show that the serum hHGF concentration is elevated in gastric carcinoma patients with liver and nodal metastasis. In multivariate analysis, the serum hHGF concentration was found to be the most important independent factor in predicting overall survival. Thus, the current results suggest that HGF may be important in the progression and metastasis of gastric carcinoma. PMID- 9951945 TI - Eradiction of H. pylori results in regression of B-cell low grade gastric MALToma with evident B-symptoms. AB - Although it is well known that eradication of H. pylori may result in either complete or partial regression of low-grade B-cell mucosa-associated lymphoid tissue lymphoma (MALToma), it would be of clinical interest to determine whether the B-symptoms of patients with MALToma could be relieved by eradication of H. pylori. Here, we report on a 29 year-old female case with B-cell low-grade gastric MALToma with apparent B-symptoms. Her peripheral blood also disclosed large granular lymphocytes (LGL). The B-symptoms of this patient were quickly relieved within 2 weeks after starting an anti-H. pylori regimen; peripheral blood LGLs were clearly decreased as well. Complete regression of MALToma was determined 4 months after the anti-H. pylori regimen. Thereafter, the patient has been disease-free and in good general condition during a 2-year follow-up. PMID- 9951946 TI - Gastric leiomyosarcoma mimicking a cystic tumor at the pancreatic tail--one case report. AB - A 73 year-old female patient suffered from anemia and a palpable abdominal mass. Abdominal ultrasonography and magnetic resonance imaging revealed a lesion with papillary excrescences at the pancreatic tail. Endoscopic retrograde cholangiopancreatography showed a normal pancreatic duct, but a small submucosal tumor was found in the stomach incidentally. Laparotomy disclosed an exophytic tumor arising from the submucosal layer of the stomach. Pathology revealed a gastric leiomyosarcoma with remarkable liquefaction and cystic change. Gastric leiomyosarcoma can be so necrotic as to be mistaken for a cystic tumor. It is critically important to differentiate the peripancreatic cystic lesion because the treatment strategy is totally different. PMID- 9951947 TI - Drug treatment of asthma in the 1990s: achievements and new strategies. AB - Asthma is an inflammatory condition of the airways. First-line therapy involves the use of inhaled corticosteroids as anti-inflammatory agents to control the underlying process. Bronchodilators are used for symptom relief. Short-acting beta-agonists provide rapid relief of bronchoconstriction, whereas long-acting beta-agonists control the symptoms and reduce the frequency of exacerbations when combined with inhaled corticosteroids. Anticholinergic bronchodilators have a minor role in acute exacerbations and in patients troubled by adverse effects from beta-agonists. Theophylline has a bronchodilator action in asthma, but its role as an anti-inflammatory agent needs to be examined further. Because of their toxicity, corticosteroid-sparing agents have a limited role, being restricted to patients with severe uncontrolled asthma. New selective phosphodiesterase IV inhibitors show both anti-inflammatory and bronchodilator characteristics with fewer adverse effects. Other new approaches to the control of inflammation come from the antileukotriene drugs, which improve pulmonary function in patients with chronic asthma. The antileukotrienes have shown promising results, especially in the treatment of asthma caused by aspirin (acetylsalicylic acid), exercise and cold air. Other new therapies being studied include anti-immunoglobulin E, antitryptase and anti-CD4 agents. These newer possibilities suggest that the range of available treatment options will expand significantly over the next decade. PMID- 9951948 TI - Alpha-adrenoceptor antagonists in the treatment of benign prostatic hyperplasia. AB - Lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH) have a significant impact on the lifestyle of older men. Transurethral resection of the prostate (TURP) is the most effective surgical therapy for this condition but an increasing number of patients are electing conservative medical therapy. Alpha Adrenoceptor antagonists and 5alpha-reductase inhibitors are the 2 categories of drug therapy currently available for BPH. Use of alpha-adrenoceptor antagonists in the treatment of BPH is based on their ability to prevent the neural stimulation which induces prostate smooth muscle contraction, producing lower urinary tract symptoms. Several studies have demonstrated that alpha-receptors predominate in the prostatic stroma, capsule and bladder neck. Initial work focused on the use of phenoxybenzamine, a nonspecific alpha-blocker, in the treatment of BPH. While results were promising, significant adverse effects and concern over potential mutagenicity have resulted in a lack of use of this medication for this indication. Subsequent attention was directed towards the short-acting alpha-specific antagonist prazosin. Results conflicted regarding whether an actual sustained improvement in lower urinary tract symptoms could be achieved with this medication, and because of twice daily dosing compliance issues were a drawback. Thus, the mainstay in pharmacological treatment of BPH over the past decade has been 2 once-a-day alpha-specific antagonists, doxazosin and terazosin. Over 75% of all prescriptions written for BPH are for one of these 2 medications. Despite their tremendous success in both decreasing urinary symptoms and increasing urinary flow rates, systemic adverse effects can be bothersome. Recently, efforts have focused on use of alpha1A-urospecific antagonists such as tamsulosin and alfuzosin in an attempt to achieve similar clinical results as doxazosin and terazosin without systemic adverse effects. Thus far, results are promising, but long term studies must be done to determine whether pharmacological uroselectivity is actually clinically relevant. PMID- 9951949 TI - Drug therapy of postprandial hyperglycaemia. AB - It is widely accepted that the most challenging goal in the management of patients with diabetes mellitus is to achieve blood glucose levels as close to normal as possible. In general, normalising postprandial blood glucose levels is more difficult than normalising fasting hyperglycaemia. In addition, some epidemiological studies suggest that postprandial hyperglycaemia (PPHG) or hyperinsulinaemia are independent risk factors for the development of macrovascular complications of diabetes mellitus. Recently, several drugs with differing pharmacodynamic profiles have been developed which target PPHG. These include insulin lispro, amylin analogues, alpha-glucosidase inhibitors and meglitinide analogues. Insulin lispro has a more rapid onset of action and shorter duration of efficacy compared with regular human insulin. In clinical trials, the use of insulin lispro was associated with improved control of PPHG and a reduced incidence of hypoglycaemic episodes. Repaglinide, a meglitinide analogue, is a short-acting insulinotropic agent which. when given before meals, stimulates endogenous insulin secretions and lowers postprandial hyperglycaemic excursions. Both insulin lispro and repaglinide are associated with postprandial hyperinsulinaemia. In contrast, amylin analogues reduce PPHG by slowing gastric emptying and delivery of nutrients to the absorbing surface of the gut. Alpha Glucosidase inhibitors such as acarbose, miglitol and voglibose also reduce PPHG primarily by interfering with the carbohydrate-digesting enzymes and delaying glucose absorption. With the availability of agents which preferentially reduce postprandial blood glucose excursions, it is now possible to achieve glycaemic goals in a larger proportion of individuals with diabetes mellitus. PMID- 9951952 TI - Practical recommendations for the management of adenocarcinoma of the pancreas. AB - Pancreatic cancer is widely regarded by medical personnel and the lay public as one of the most dreaded of all diagnoses. Although in selected series of operable patients the chance of long term survival may reach 20%, most patients have unfavourable disease at the time of diagnosis, and for the entire group of newly diagnosed patients, 5-year survival is rare. This grim outlook results from a combination of factors, including an anatomical location which makes early detection by screening tests or by symptoms difficult, a high tendency for spread to regional lymphatics and the liver, a poor profile of sensitivity to chemotherapeutic agents and the poor medical condition of many patients at the time of diagnosis. These factors mean that it is particularly important that at the time of diagnosis these patients are carefully evaluated, and that they and their families are fully aware of the treatment options available to them and the associated potential risks and benefits. For localised cancers, surgical resection alone offers the potential for long term survival. The addition of postoperative radiation therapy (RT) predictably improves local control but has minimal impact on survival, which is primarily determined by the development of liver metastases. Randomised trial data support the use of combined fluorouracil (5-FU) chemotherapy and RT in patients who have undergone pancreatectomy and have negative margins, although the benefits are modest and the relevant randomised trials enrolled relatively small patient numbers. For patients with marginally resectable tumours, the feasibility has been demonstrated of using chemotherapy plus RT to reduce tumour size before resection, but it is unclear whether this approach will benefit a significant number of patients. Tumours which are unresectable because of local advancement (involvement of major vessels or regional nodes) can be treated with RT alone or in combination with chemotherapy, but survival past 2 years is uncommon. Patients with liver metastases have a poor prognosis. As part of a programme of supportive care, some of these patients may receive cytotoxic therapy, the goal of which is to relieve cancer-related symptoms such as pain from the primary tumour or metastatic sites, or weakness, nausea and anorexia which may be associated with liver metastases. Although the objective response rate of chemotherapy agents is low, in an individual patient they may produce an adequate response and acceptable toxicity so that the patient experiences overall improvement in symptoms. The mainstay of chemotherapy for pancreatic cancer, as with other gastrointestinal cancers, has been fluorouracil. However, recent clinical data have shown that gemcitabine produces similar results in terms of response rate and survival, with more acceptable toxicity, so that the quality of life was judged to be better than with fluorouracil. Pancreatic cancer provides a fertile ground for testing new, biologically based approaches to cancer therapy because of the limited success of currently available treatments. PMID- 9951954 TI - Long-acting isosorbide mononitrate. AB - Elantan long (EL) is the only long-acting isosorbide mononitrate formulation based on a controlled membrane principle. 30% of the dose is available for immediate release and the remaining 70% is gradually released over time. After oral administration, isosorbide mononitrate EL has a quick onset of action (30 minutes) and effects are evident for up to 17 hours. The antianginal effects of once-daily isosorbide mononitrate EL 50 to 100mg were generally similar to those of conventional isosorbide mononitrate or isosorbide dinitrate 10 to 20mg twice or 3 times daily, or sustained-release nifedipine 20mg twice or 3 times daily. Patients tended to show a better response with once-daily isosorbide mononitrate EL 50mg than with bupranolol 100mg. Patients showed significantly greater improvement in some quality-of-life indices with once-daily isosorbide mononitrate EL than with twice or 3 times daily regimens of conventional isosorbide mononitrate or isosorbide dinitrate. Tolerance did not develop after 13 months of once-daily administration of isosorbide mononitrate EL. No rebound increase in incidence of ischaemic episodes was observed after discontinuation of the drug. PMID- 9951950 TI - Second-generation antihistamines: a comparative review. AB - Second-generation histamine H1 receptor antagonists (antihistamines) have been developed to reduce or eliminate the sedation and anticholinergic adverse effects that occur with older H1 receptor antagonists. This article evaluates second generation antihistamines, including acrivastine, astemizole, azelastine, cetirizine, ebastine, fexofenadine, ketotifen, loratadine, mizolastine and terfenadine, for significant features that affect choice. In addition to their primary mechanism of antagonising histamine at the H1 receptor, these agents may act on other mediators of the allergic reaction. However, the clinical significance of activity beyond that mediated by histamine H1 receptor antagonism has yet to be demonstrated. Most of the agents reviewed are metabolised by the liver to active metabolites that play a significant role in their effect. Conditions that result in accumulation of astemizole, ebastine and terfenadine may prolong the QT interval and result in torsade de pointes. The remaining agents reviewed do not appear to have this risk. For allergic rhinitis, all agents are effective and the choice should be based on other factors. For urticaria, cetirizine and mizolastine demonstrate superior suppression of wheal and flare at the dosages recommended by the manufacturer. For atopic dermatitis, as adjunctive therapy to reduce pruritus, cetirizine, ketotifen and loratadine demonstrate efficacy. Although current evidence does not suggest a primary role for these agents in the management of asthma, it does support their use for asthmatic patients when there is coexisting allergic rhinitis, dermatitis or urticaria. PMID- 9951951 TI - Drug therapy in the management of type 1 autoimmune hepatitis. AB - Prednisone alone or in combination with azathioprine is the treatment of choice for severe type 1 autoimmune hepatitis. The combination regimen is preferred, especially in the elderly, because of a lower incidence of corticosteroid-related complications. Only patients with sustained severe laboratory abnormalities, bridging necrosis or multilobular necrosis on histological assessment, and/or incapacitating symptoms, have absolute indications for treatment based on controlled clinical trials. The institution of therapy must be individualised in other patients, based mainly on symptoms and disease behaviour. Serum aspartate aminotransferase and gamma-globulin levels are the most useful indices to monitor during therapy. Liver tissue examination is the best method of evaluating completeness of response. Most patients enter remission, but relapse occurs in 50 to 86% after drug withdrawal. Maintenance therapy with low dosages of prednisone or azathioprine can be used long term in patients who have relapsed repeatedly. Inability to achieve remission after 3 years (incomplete response), deterioration during therapy (treatment failure) and drug toxicity are unsatisfactory responses that warrant alternative strategies. Liver transplantation is effective in managing decompensated disease, but recurrence of autoimmune hepatitis after transplantation is possible. Tacrolimus and budesonide are promising new drugs. PMID- 9951955 TI - Ibandronate. AB - Ibandronate (ibandronic acid) is a third generation bisphosphonate which inhibits hone resorption in human and animal studies. It also inhibits bone formation only at high doses (10 microg/kg/day) in animal studies. In animal models, ibandronate was more potent than etidronate, clodronate, pamidronate and alendronate and equivalent in potency or more potent than risedronate in inhibiting induced hypercalcaemia and bone resorption. In clinical studies, single-dose ibandronate (0.2 to 6 mg intravenously) significantly reduced albumin-corrected serum calcium levels and urinary markers of bone resorption in patients with hypercalcaemia of malignancy, and in those with bone metastases. Serum calcium levels were normalised in 50 and 67% of ibandronate 2 mg recipients and in about 76% of 4 mg recipients. In postmenopausal women with osteoporosis or osteopenia. ibandronate (0.5 to 5 mg/day orally or 0.5 to 2 mg every 3 months intravenously) dose dependently increased bone mineral density, with parallel reductions in the biochemical markers of bone turnover. In preliminary studies in patients with Paget's disease a single intravenous ibandronate dose (2mg) decreased serum alkaline phosphatase levels and urinary markers of bone turnover. Adverse events associated with the use of ibandronate in the management of hypercalcaemia of malignancy include increased body temperature, hypocalcaemia and hypophosphataemia. Less commonly, flu-like symptoms and gastrointestinal intolerance may occur. PMID- 9951956 TI - Finasteride: a review of its use in male pattern hair loss. AB - The 5alpha-reductase inhibitor finasteride blocks the conversion of testosterone to dihydrotestosterone (DHT), the androgen responsible for male pattern hair loss (androgenetic alopecia) in genetically predisposed men. Results of phase III clinical studies in 1879 men have shown that oral finasteride 1 mg/day promotes hair growth and prevents further hair loss in a significant proportion of men with male pattern hair loss. Evidence suggests that the improvement in hair count reported after 1 year is maintained during 2 years' treatment. In men with vertex hair loss, global photographs showed improvement in hair growth in 48% of finasteride recipients at 1 year and in 66% at 2 years compared with 7% of placebo recipients at each time point. Furthermore, hair counts in these men showed that 83% of finasteride versus 28% of placebo recipients had no further hair loss compared with baseline after 2 years. The clinical efficacy of oral finasteride has not yet been compared with that of topical minoxidil, the only other drug used clinically in patients with male pattern hair loss. Therapeutic dosages of finasteride are generally well tolerated. In phase III studies, 7.7% of patients receiving finasteride 1 mg/day compared with 7.0% of those receiving placebo reported treatment-related adverse events. The overall incidence of sexual function disorders, comprising decreased libido, ejaculation disorder and erectile dysfunction, was significantly greater in finasteride than placebo recipients (3.8 vs 2.1%). All sexual adverse events were reversed on discontinuation of therapy and many resolved in patients who continued therapy. No other drug-related events were reported with an incidence > or =1% in patients receiving finasteride. Most events were of mild to moderate severity. Oral finasteride is contraindicated in pregnant women because of the risk of hypospadias in male fetuses. CONCLUSIONS: Oral finasteride promotes scalp hair growth and prevents further hair loss in a significant proportion of men with male pattern hair loss. With its generally good tolerability profile, finasteride is a new approach to the management of this condition, for which treatment options are few. Its role relative to topical minoxidil has yet to be determined. PMID- 9951953 TI - Biliary tract infections: a guide to drug treatment. AB - Initial therapy of acute cholecystitis and cholangitis is directed towards general support of the patient, including fluid and electrolyte replacement, correction of metabolic imbalances and antibacterial therapy. Factors affecting the efficacy of antibacterial therapy include the activity of the agent against the common biliary tract pathogens and pharmacokinetic properties such as tissue distribution and the ratio of concentration in both bile and serum to the minimum inhibitory concentration for the expected micro-organism. Antimicrobial therapy is usually empirical. Initial therapy should cover the Enterobacteriaceae, in particular Escherichia coli. Activity against enterococci is not required since their pathogenicity in biliary tract infections remains unclear. Coverage of anaerobes, in particular Bacteroides spp., is warranted in patients with previous bile duct-bowel anastomosis, in the elderly and in patients in serious clinical condition. In patients with acute cholecystitis or cholangitis of moderate clinical severity, monotherapy with a ureidopenicillin--mezlocillin or piperacillin--is at least as effective as the combination of ampicillin plus aminoglycoside. In severely ill patients with septicaemia, an antibacterial combination is preferable. Therapy with aminoglycosides, mostly for Pseudomonas aeruginosa-related infections, should not exceed a few days because the risk of nephrotoxicity seems to be increased during cholestasis. Relief of biliary obstruction is mandatory, even if there is clinical improvement with conservative therapy, because cholangitis is most likely to recur with continued obstruction. Emergency invasive therapy is reserved for patients who fail to show a clinical response to antibacterial therapy within the first 36 to 48 hours or for those who deteriorate after an initial clinical improvement. Immediate surgery is indicated for gangrenous cholecystitis and perforation with peritonitis. Long term administration of antibacterials is required for recurrent cholangitis, as seen in bile duct-bowel anastomosis. Oral cotrimoxazole (trimethoprim/sulfamethoxazole) is the preferred agent. Wound infection rates after biliary tract surgery can be significantly reduced by preoperative administration of prophylactic antibacterials. Newer generation beta-lactams have not proven to be of greater benefit than older agents such as cefuroxime or cefazolin. Antibacterial prophylaxis before endoscopic retrograde cholangiopancreatography (ERCP) should be reserved for patients with obstructive jaundice, since the risk of infectious complications seems to be strongly associated with this clinical condition. Failure to achieve full biliary drainage is the most important factor in predicting septicaemia, and prophylaxis should be prolonged until the bile duct is unobstructed. Piperacillin, cefazolin, cefuroxime, cefotaxime and ciprofloxacin are effective for this indication. PMID- 9951957 TI - The efficacy of pentamidine combined with allopurinol and immunotherapy for the treatment of patients with diffuse cutaneous leishmaniasis. AB - A new treatment regimen was tested on patients with incurable diffuse cutaneous leshmaniasis (DCL) infected with Leishmania mexicana mexicana in Mexico. Two patients with advanced stages of the disease were treated with polychemotherapy (pentamidine and allopurinol) combined with recombinant human interferon-gamma (rIFN-gamma). For determination of the best medication, parasites isolated from patient lesions were exposed to available drugs both as promastigotes and as intracellular amastigotes. A synergistic effect was observed in vitro for the combination of pentamidine and allopurinol. Both patients were treated and recovered rapidly, but one of them developed insulin-dependent type I diabetes because of pentamidine toxicity. The complication was controlled and both patients were discharged with an apparent parasitologic cure, but after 3 months the two patients began to relapse. Our results suggest that allopurinol pentamidine polychemotherapy, involving reduced dosage of pentamidine, combined with rIFN-gamma is an alternative for DCL patients infected with L. m. mexicana. PMID- 9951958 TI - Tubular structures associated with Babesia caballi in equine erythrocytes in vitro. AB - In-vitro-propagated Babesia caballi parasites were examined by scanning and transmission electron microscopy. Many small pores were observed over the entire surface of infected erythrocytes on scanning electron microscopy, and on transmission electron microscopy these small pores were found to be openings of tubular structures. By the examination of a number of infected cells the tubular structures were found to be connected with the parasite, and this observation might indicate that the tubular structures arose the edge of the parasite and terminated at an Invagination on the surface of the erythrocyte. These findings suggest that intraerythrocytic stages of B. caballi come into direct contact with culture medium. PMID- 9951959 TI - Development of a quantitative, competitive polymerase chain reaction--enzyme linked immunosorbent assay for the detection of Wuchereria bancrofti DNA. AB - A quantitative, competitive polymerase chain reaction (QC-PCR) assay for the sensitive detection of Wuchereria bancrofti DNA was developed. A competitor sequence was constructed by an exchange of nucleotides in the Wuchereria-specific Ssp I repeat. The PCR products were hybridized to specific DNA probes and their amounts, determined by an enzyme-linked immunosorbent assay (ELISA). In laboratory-prepared samples the QC-PCR-ELISA assay was capable of detecting the amount of DNA equivalent to 0.1 microfilaria (mf) added to 200 microl of blood lysate. The assay was also tested on 78 blood samples collected in endemic areas in Egypt. All 28 samples that were positive both for mf and for circulating antigen were also QC-PCR-ELISA-positive. In addition, one mf-negative but antigen positive sample was also positive as determined by QC-PCR-ELISA. A positive correlation of mf density with the QC-PCR-ELISA was observed. Samples containing 10 or fewer mf/ml had a mean relative amount of Ssp I PCR product of 19.7 units, whereas samples with 11-100 mf/ml had a mean of 36.3 units and those with more than 100 mf/ml had a mean of 84.6 units. Because of the high standard deviation within each group, estimates of worm burdens in infected individuals using the QC PCR-ELISA are not recommended. However, we present data indicating that the W. bancrofti QC-PCR-ELISA is a powerful new tool for evaluation of parasitic loads for community-based diagnosis of bancroftian filariasis. PMID- 9951960 TI - Neolignans inhibit Trypanosoma cruzi infection of its triatomine insect vector, Rhodnius prolixus. AB - Two neolignans, burchellin and nordihydroguaiaretic acid (NDGA), were toxic only to Trypanosoma cruzi clone Dm28c maintained in brain heart infusion (BHI) medium at a concentration of 100 microg/ml, not 10 microg/ml. When Rhodnius prolixus was fed with epimastigotes of T. cruzi and treated simultaneously with a single dose of burchellin or NDGA at 10 pg/ml of blood meal the number of parasites in the gut decreased. Whereas burchellin was only partially active, NDGA drastically reduced the number of epimastigotes and metacyclic trypomastigotes of T. cruzi in the excreta (urine plus feces). When the insect larvae were pretreated with burchellin or NDGA at 20 days before the infection with T. cruzi a significant reduction in the number of parasites in the gut occurred. However, when both compounds were applied at 20 days after the establishment of T. cruzi infection, although burchellin significantly reduced the gut infection, neither compound could abolish the infection entirely within the subsequent 15 days. PMID- 9951961 TI - Characterization by pulse-field electrophoresis of a new region of DNA amplification containing the M2 subunit of ribonucleotide reductase in hydroxyurea-resistant Leishmania. AB - An extrachromosomal circular DNA of of approximately 50-kb size was amplified in the hydroxyurea-resistant variant of Leishmania mexicana amazonensis. The amplicon carried the M2 gene of ribonuleotide reductase as part of the gene encoding resistance to hydroxyurea. The amplicon was unstable. It disappeared rapidly as shown in pulse-field gradient electrophoresis gels after reversion of the cells for 20-80 days. This loss of amplified DNA was accompanied by a rapid loss of resistance to hydroxyurea during the same period. The amplicon was not hybridized to specific probes from any of the four regions of DNA amplification previously reported for Leishmania. This region of amplification thus appears to be a new region of DNA amplification in Leishmania. PMID- 9951963 TI - Experimental Angiostrongylus costaricensis infection in mice: immunoglobulin isotype responses and parasite-specific antigen recognition after primary low dose infection. AB - Immunoglobulin isotype responses and parasite-specific antigen recognition were investigated in experimental Angiostrongylus costaricensis infection in two different mouse strains. Even in a low-dose infection with third-stage larvae (L3), BALB/c mice showed high mortality until 28 days postinfection (p.i.) in association with a low patency rate in surviving animals. On the other hand, low mortality and a high rate of patent infection was observed in C57BL/10 mice. Parasite-specific IgM, total IgG, and IgG subclasses against crude adult-worm antigen (AcAg) rose in both groups of mice from day 14 onward, with IgG and IgG1 being significantly elevated in BALB/c mice at 21 and 28 days p.i., respectively. For total IgE, significantly elevated concentrations were detected at 14 days p.i. in BALB/c mice as compared with C57BL/10 mice. A. costaricensis-specific antigen recognition by total IgG, IgG1, or IgG2a was similar in both mouse strains, intensifying from 3 to 4 weeks p.i., with recognition of immunodominant AcAg ranging between 80 and 210 kDa. This study provides evidence that in BALB/c and C57BL/10 mice, immunoglobulins, with the possible exception of IgE and IgG1, do not decisively contribute to the outcome of a primary A. costaricensis infection with respect to immunopathogenesis or parasite permissiveness. PMID- 9951962 TI - B-cell activation in the mesenteric lymph nodes of resistant BALB/c mice infected with the murine nematode parasite Trichuris muris. AB - Immune responses in resistant BALB/c mice infected with the murine nematode parasite Trichuris muris were examined. Following the establishment of infection, worm burdens of T. muris were expelled by BALB/c mice by day 21 postinfection (p.i.). Specific immunoglobulin G1 (IgG1) antibodies to T. muris excretory/secretory (E/S) antigens were detected in sera from infected mice, though specific IgG2a antibodies were not observed during infection. Ig-producing cells increased in the mesenteric lymph nodes (MLN) of infected mice on days 7, 14, and 21 p.i., with the greatest increase in numbers of IgG- and IgA-producing cells occurring on day 14. Marked increases in the relative percentages of B220+ and surface Ig+ (sIg+) cells were observed in the MLN of infected mice on days 14 and 21 p.i. Furthermore, cellular expansion of the MLN in infected mice resulted in an increase in the absolute numbers of B220+ and sIg+ cells. The levels of interleukin 2 (IL-2), IL-4, and interferon-gamma (IFN-gamma) detected in the supernatants from concanavalin A-stimulated MLN cells of infected mice were higher than those found in normal mice. Consequently, the expulsion of T. muris in resistant BALB/c mice was concomitant with cytokine production and B-cell activation in the MLN of infected mice. These results suggest the involvement of B-cell responses in protective immunity to T. muris infection. PMID- 9951964 TI - Polymerase chain reaction and DNA probe hybridization to assess the efficacy of diminazene treatment in Trypanosoma brucei-infected cattle. AB - Four of eight Ankole longhorn cattle experimentally infected with Trypanosoma brucei were treated with 7 mg/kg diminazene aceturate (Berenil, Hoechst AG, Germany) at day 71 postinfection. The trypanocidal activity was monitored using polymerase chain reaction (PCR) and DNA probe hybridization. When extracted parasite DNA (without host DNA) was used, as little as 1 fg per reaction, which is equivalent to about 1-10% of the DNA in a single trypanosome, produced a specific product that was visible as a 177-bp band in an agarose gel. In infected cattle, specific PCR products could be amplified at as early as 1 day postinfection. PCR signals remained positive during infection, except in one sample, although aparasitemic phases occurred. In cases where treatment resulted in a significant clinical improvement, PCR signals disappeared at 3-4 days after the administration of the drug. By contrast, in cattle that showed clinical signs of CNS involvement after treatment, although aparasitemic, and died before the termination of the experiment, specific products could be amplified on several occasions following treatment. The PCR signals generated after treatment could be further enhanced by subsequent slot-blot hybridization with a T. brucei-specific DNA probe. We conclude that PCR coupled with DNA probe hybridization provides a highly sensitive tool for the assessment of therapeutic efficiency and disease progression in trypanosome infections, especially in chronic infections when the level of parasitemia is low or when trypanosomes are sequestered at cryptic sites. PMID- 9951965 TI - Miracidial infectivity of Hypoderaeum conoideum (Trematoda: Echinostomatidae): differential susceptibility of two lymnaeid species. AB - A study was made of the infectivity of Hypoderaeum conoideum miracidia to a range of laboratory-reared specimens of freshwater snail species (Lymnaea peregra, L. corvus, Physella acuta, and Gyraulus chinensis) that coexist with the parasite in the same natural habitat. L. peregra and L. corvus were found to be equally susceptible to the parasite when specimens of each snail species were singly exposed to miracidia. However, when miracidia could choose either lymnaeid species, they showed a high degree of specificity toward L. peregra. The results obtained suggest that H. conoideum miracidia are capable of distinguishing among these lymnaeids in their orientation to the host. This indicates that miracidia might achieve specificity before actually contacting the snail host and suggests that during the host-snail orientation process they respond to signals different from those generated upon snail contact and invasion. The specificity toward L. peregra observed in H. conoideum miracidia seems to indicate adaptation to the snail community in their natural habitat, resulting in enhancement of their transmission. PMID- 9951966 TI - Ultrastructural investigation of the spore-forming protist Nephridiophaga blattellae in the Malpighian tubules of the German cockroach Blattella germanica. AB - Multinuclear plasmodia of the sporogenic protist Nephridiophaga blattellae are found intracellularly and in the lumen of the Malpighian tubules of the German cockroach Blattella germanica. Spore formation occurs only in the lumen. During sporogony, about 10-35 spores measuring 5.5x3.2 microm are endogenously formed within a plasmodium. Sporoblasts arise by the fusion of cisternae of the endoplasmic reticulum into a double membranous wall, which encloses a generative nucleus plus a portion of cytoplasm. Several somatic nuclei remain in the residual cytoplasm. Sporoblast and residual cytoplasm include mitochondria of the tubular type, endoplasmic reticulum, and many free ribosomes. During spore maturation, electron-dense wall material is deposited between the spore membranes, and the spores gain their typical oval, biconcave form. Freeze-etched spores reveal a small, central, cap-like structure, which may be the site where an infectious sporoplasm could emerge. Mature spores always have one nucleus, whereas early sporoblast stages with two small nuclei were found by transmission electron microscopy. Many nuclei of different developmental stages contain granules within the nuclear envelope. The systematic position of N. blattellae is unresolved. In certain respects it is reminiscent of Haplosporidia. However, the organisms of the two groups have different spore-forming processes and haplosporosomes are missing in the nephridiophagids. Therefore a new phylum might have to be erected for members of the family Nephridiophagidae. PMID- 9951967 TI - Effects of fluorinated inositols on the phosphoinositide metabolism and the proliferation of Trypanosoma cruzi. AB - Inositol has been cited as being essential for the growth of micro-organisms and animals. Its action rests mostly in the formation of a set of inositol-containing lipids, including phosphatidylinositol and its phosphorylated derivatives. To evaluate the functional responses coupled to the phosphoinositide metabolism in Trypanosoma cruzi we used myo-inositol and its six fluorinated analogues. Their uptake into epimastigotes was characterised using tritium-labeled myo-inositol and monodeoxyfluoro-myo-inositols. The analogues were tested for their ability to inhibit [3H]-myo-inositol incorporation into phosphoinositides and the proliferation of epimastigotes and amastigotes. The results showed differences between T. cruzi and mammalian systems in the responses to the fluorinated analogues. We found that the 3-, 5- and 6-fluoro analogues did not enter the cells but had an inhibitory effect on the incorporation of the radioactive inositol into lipids and on the amastigotes' and epimastigotes' replication. The most effective inhibitor, 1-D-6-deoxy-6-myo-inositol, had no effect on mammalian cell division. PMID- 9951968 TI - Schistosoma haematobium: comparative studies on the characteristics of infection in three populations of Planorbarius metidjensis from the Agadir province in South Morocco. AB - Planorbarius metidjensis measuring 2 or 3 mm in diameter and originating from three populations in the Agadir province (Ida Ou Gnidif, Imouzzer, and Sidi Belkacem) were experimentally infected with Schistosoma haematobium to determine if the complete larval development of the parasite might be ensured by any snail population of the Agadir province and to compare the general characteristics of infection. No significant difference between the three populations was noted in the survival rates of snails when the first shedding occurred or in the prevalence of infection. The mean duration of the shedding period was significantly higher in the Imouzzer population (111 days versus 53-58 days). The total number of cercariae shed per mollusc was significantly lower in the Ida Ou Gnidif planorbids (1,398/snail versus 3,346 and 3,343/snail in the other 2 groups). The same rhythm in daily cercarial production was noted in the three snail groups, with the periodicity being 18-20 days. Despite some differences in parasite development between the three snail populations, the different populations of P. metidjensis can ensure the complete development of S. haematobium and maintain local transmission in the South of Morocco. PMID- 9951969 TI - Nested polymerase chain reaction for detection of Theileria annulata and comparison with conventional diagnostic techniques: its use in epidemiology studies. AB - In this work we studied the ability of a nested polymerase chain reaction (PCR) to detect Theileria annulata, the causative agent of Mediterranean theileriosis, in blood samples obtained from cattle on farms in different Spanish regions and its possible use in epidemiology studies. Of the 214 samples analyzed, 78.04%, 69.86%, and 62.26% were found to be positive by nested PCR, indirect immunofluorescent antibody test, and optical microscopy of Giemsa-stained smears, respectively. The three techniques were in agreement in 68.6% of the results. The observation that the prevalence of Mediterranean theileriosis estimated using nested PCR alone (70.3%) and that obtained using all three diagnostic techniques together (80.4%) did not significantly differ verifies the utility of this technique in epidemiology studies. PMID- 9951970 TI - Alpha-tubulins of Tritrichomonas mobilensis are encoded by multiple genes and are not posttranslationally tyrosinated. AB - Reverse-transcriptase polymerase chain reaction cloning of the 3'-ends of the alpha-tubulin cDNAs of Tritrichomonas mobilensis in combination with Southern blot analysis identified seven to eight distinct alpha-tubulin genes. All seven lack a carboxy-terminal tyrosine and the corresponding sequence compatible with posttranslational tyrosination. This indicates that whereas tyrosination of alpha tubulin has been found in most species, including humans and trypanosomes, it is absent in trichomonads. PMID- 9951971 TI - Acute otitis media: management and surveillance in an era of pneumococcal resistance--a report from the Drug-resistant Streptococcus pneumoniae Therapeutic Working Group. AB - OBJECTIVE: To provide recommendations [corrected] for the management of acute otitis media (AOM) and the surveillance of drug-resistant Streptococcus pneumoniae (DRSP). Five questions were addressed: (1) Can amoxicillin remain the best initial antimicrobial agent for treating AOM in the current period of increasing prevalence of DRSP? (2) What are suitable alternative agents for use if amoxicillin fails? (3) Should empiric treatment of AOM vary by geographic region? (4) Where can clinicians learn about resistance patterns in their patient populations? (5) What modifications to laboratory surveillance would improve the utility of the information for clinicians treating AOM? PARTICIPANTS: Experts in the management of otitis media and the DRSP Therapeutic Working Group. This group was convened by the CDC to respond to changes in antimicrobial susceptibility among pneumococci and includes clinicians, academicians and public health practitioners. EVIDENCE: Published and unpublished data summarized from the scientific literature and experience from the experts present. PROCESS: [corrected] After group presentations and review of background materials, subgroup chairs prepared draft responses to the five questions, discussed the responses as a group and edited those responses [corrected]. CONCLUSIONS: Oral amoxicillin should remain the first line antimicrobial agent for treating AOM. In view of the increasing prevalence of DRSP, the safety of amoxicillin at higher than standard dosages and evidence that higher dosages of amoxicillin can achieve effective middle ear fluid concentrations, an increase in the dosage used for empiric treatment from 40 to 45 mg/kg/day to 80 to 90 mg/kg/day is recommended. For patients with clinically defined treatment failure after 3 days of therapy, useful alternative agents include oral amoxicillin-clavulanate, cefuroxime axetil and intramuscular ceftriaxone. Many of the 13 other Food and Drug Administration approved otitis media drugs lack good evidence for efficacy against DRSP. Currently local surveillance data for pneumococcal resistance that are relevant for the clinical management of AOM are not available from most areas in the United States. Recommendations to improve surveillance include establishing criteria for setting susceptibility breakpoints for clinically appropriate antimicrobials to ensure relevance for treating AOM, testing middle ear fluid or nasal swab isolates in addition to sterile site isolates and testing of drugs that are useful in treating AOM. The management of otitis media has entered a new era with the development of DRSP. These recommendations are intended to provide a framework for appropriate clinical and public health responses to this problem. PMID- 9951972 TI - Poliomyelitis as a paradigm for investment in and success of vaccination programs. PMID- 9951974 TI - Infection control practices and the pregnant health care worker. PMID- 9951973 TI - A case for Bacillus Calmette-Guerin vaccine in United States-born children. PMID- 9951975 TI - Hepatitis B vaccine and central nervous system demyelinating diseases. Viral Hepatitis Prevention Board. PMID- 9951976 TI - Effect of transplacentally acquired tetanus antibodies on the antibody responses to Haemophilus influenzae type b-tetanus toxoid conjugate and tetanus toxoid vaccines in Filipino infants. AB - BACKGROUND: Pregnant women in developing countries are vaccinated with tetanus toxoid (TT) to prevent neonatal tetanus. In populations in which the maternal TT vaccination program is efficiently implemented, responses of the infant to TT and TT-conjugated vaccines such as Haemophilus influenzae type b (Hib) capsular polysaccaride (PS) TT-conjugate (Hib-TT) vaccine may be depressed. OBJECTIVES: To study the influence of transplacentally acquired anti-TT antibodies on responses to TT vaccination and to Hib-TT vaccine. METHODS: One hundred ninety-four healthy Filipino infants received three doses of a Hib conjugate (either Hib-TT, PRP-OMP or HbOC) with diphtheria-tetanus-pertussis vaccine (DTP) given simultaneously but in a separate syringe at the age of 6, 10 and 14 weeks (primary series). In addition 54 of the study children received a booster dose of Hib-TT at 9 months simultaneously with the measles vaccine. RESULTS: Transplacentally acquired anti TT did not interfere with the anti-Hib PS antibody (anti-Hib PS) response to any of the conjugates. The transplacentally acquired anti-TT was not significantly associated with the concentration of anti-Hib PS either before or after the booster dose of Hib-TT. High concentrations (> or =1 IU/ml) of transplacentally acquired anti-TT inhibited the infants' anti-TT responses. CONCLUSIONS: High concentration of transplacentally acquired anti-TT did not depress anti-Hib PS responses to the Hib-TT vaccine. On the other hand the high anti-TT concentrations somewhat depressed the anti-TT responses of the infants. However, the anti-TT concentrations attained were in the protective range in all study children after either the primary series (DTP + Hib-TT) or the booster dose of Hib-TT. PMID- 9951977 TI - Comparison of human immunodeficiency virus 1 DNA polymerase chain reaction and qualitative and quantitative RNA polymerase chain reaction in human immunodeficiency virus 1-exposed infants. AB - BACKGROUND: HIV-1 RNA PCR is a widely available and sensitive assay but has not been studied for use in early diagnosis of HIV-1 infection in infants. METHODS: Research HIV-1 DNA PCR and HIV-1 RNA PCR were performed on peripheral blood mononuclear cells and plasma, respectively, from 284 blood samples from 204 infants. A commercially available HIV-1 quantitative RNA PCR was also performed on plasma from the 132 samples from HIV-1-infected infants and 22 of the samples from HIV-1-uninfected infants. RESULTS: Sensitivities of all assays varied with infant age. HIV-1 DNA PCR had a sensitivity of 27% in the < or = 3-week age group (n = 11) whereas qualitative and quantitative RNA PCR had sensitivities of 64 and 55%, respectively (P not significant). Each assay had a sensitivity of 96.2% at 4 to 6 weeks (n = 26) and 100% at > or = 7 weeks of age (n = 95). Specificity of HIV-1 DNA PCR for all age groups was 100%, whereas specificities of qualitative and quantitative RNA PCR assay were 96.1 and 95.5%, respectively. CONCLUSIONS: HIV-1 RNA PCR may offer a slight advantage in sensitivity over DNA PCR in the diagnosis of HIV infection in young infants. Positive RNA results can be found in a small number of infants who are not HIV-1-infected. HIV-1 RNA detection should not be routinely used alone for the diagnosis of HIV infection in young infants. PMID- 9951978 TI - Clinical implications of penicillin and ceftriaxone resistance among children with pneumococcal bacteremia. AB - OBJECTIVES: To determine whether reduced penicillin or ceftriaxone susceptibility affects clinical presentation and outcome in children with pneumococcal bacteremia. DESIGN: Retrospective review of patients with Streptococcus pneumoniae bacteremia. RESULTS: We reviewed 922 cases of pneumococcal bacteremia. Of 744 isolates with known penicillin (PCN) susceptibilities 56 were PCN nonsusceptible. The majority displayed intermediate resistance; 14 of 730 isolates with known ceftriaxone (CTX) susceptibilities were CTX-nonsusceptible. Neither the PCN- nor the CTX-nonsusceptible cohort displayed a difference from its susceptible counterpart in temperature, respiratory rate or white blood cell count on initial patient evaluation, although trend suggested they were more often admitted at the initial visit. At follow-up only children treated initially with antibiotic were evaluated. Children with PCN-nonsusceptible isolates were no more likely to be febrile than those with PCN-susceptible isolates (28% vs. 25%, P = 0.61) and were no more likely to have a positive repeat blood culture (0% vs. 1%, P = 0.59) or a new focal infection (10% vs. 6%, P = 0.79). Data concerning CTX-nonsusceptible organisms were limited by the low number of such isolates. Although patients with CTX-nonsusceptible pneumococci were more likely to be febrile at follow-up than those with CTX-susceptible organisms (67% vs. 24%, P = 0.04), we were unable to demonstrate a significant difference for other endpoints. CONCLUSIONS: Reduced antibiotic susceptibility does not alter the clinical presentation of pneumococcal bacteremia. With current practice intermediate resistance to PCN is of little clinical significance in nonmeningitic systemic pneumococcal infections. PMID- 9951979 TI - Reactogenicity and immunogenicity of a new live attenuated combined measles, mumps and rubella vaccine in healthy children. AB - OBJECTIVE: To compare the reactogenicity and immunogenicity of a novel live attenuated measles-mumps-rubella vaccine, SB MMR (Priorix; SmithKline Beecham Biologicals), with a widely used MMR vaccine, Merck MMR (M-M-R II; Merck & Co. Inc). METHODS: A total of 4702 healthy children, ages 9 to 24 months, were enrolled in 8 single blind, randomized, controlled trials. Reactogenicity (local and general solicited symptoms and all unsolicited symptoms) was assessed for up to 42 days postvaccination. Immunogenicity [seroconversion rates and geometric mean titers (GMT)] was assessed at 42 or 60 days postvaccination in 1912 subjects in 7 studies. In two studies the persistence of the antibodies at Month 12 postvaccination was assessed in 201 subjects. RESULTS: Local symptoms (pain on or immediately after injection; pain, redness and swelling within 4 days of injection) were reported less frequently after SB MMR than Merck MMR (P < 0.0001). General symptoms and all other events were similar between the two groups. Fever >39.5 degrees C was reported after 9.5 and 11.9% of the SB MMR and Merck MMR doses, respectively. At Days 42 to 60 postvaccination seroconversion rates for antimeasles antibodies were higher with SB MMR than with Merck MMR (98.7% vs. 96.9%, P < 0.031) but similar in both groups for anti-mumps and anti rubella antibodies, GMTs being approximately 10% higher (P < 0.05) with Merck MMR than with SB MMR. At the Month 12 assessment the seropositivity rates and GMTs were similar in both groups. CONCLUSION: When administered as primary vaccination in children in the second year of life, the new SB MMR vaccine has been shown to be superior to a comparator vaccine in terms of local reactogenicity, with equivalent immunogenicity. PMID- 9951980 TI - Increased long term mortality associated with rash after early measles vaccination in rural Senegal. AB - OBJECTIVES: To examine whether clinical symptoms, including rash, were more common after measles immunization compared with placebo and to study the association between postvaccination symptoms and later mortality. DESIGN: Examination of side effects in the 3 weeks after immunization in a trial of high titer and standard titer measles vaccines. PATIENTS: Two hundred twenty-four children randomly selected to be included in the surveillance for diarrhea, fever and rash. RESULTS: There was no difference in fever and diarrhea between recipients of high titer vaccines and recipients of placebo. However, high titer recipients tended to have more measles-like rashes than placebo recipients [relative risk, 2.12 (range, 0.90 to 5.03)]. Among recipients of high titer vaccines, children who presented a rash had higher mortality in the following 5 to 7 years than those who did not develop rash [mortality rate ratio, 3.85 (range, 1.52 to 9.79)]. High titer recipients without a rash had the same mortality as children in the placebo group who were given standard doses of measles vaccine at 10 months of age [mortality rate, 0.76 (range, 0.35 to 1.62)]. CONCLUSIONS: These observations suggest that in this particular study, rash after high titer measles vaccine may identify children who received a particularly high dose of vaccine or children with more severe and persistent postvaccination immunosuppression. Whether high titer vaccine is more likely than standard titer measles vaccine to provoke such reaction is not known, given that we did not compare side effects after different titers of measles vaccine. Future trials of live measles vaccine should monitor the development of rash. PMID- 9951981 TI - Poor serologic responses five to seven years after immunization with high and standard titer measles vaccines. AB - BACKGROUND: Few data exist on the persistence of measles antibodies after vaccination of West African infants. Therefore we examined measles antibody titers 5 to 7 years after children in rural Senegal had received high titer Edmonston-Zagreb (EZ-HT), high titer Schwarz (SW-HT) or standard titer Schwarz (SW-STD) measles vaccines in infancy. METHODS: Children had received either high titer vaccines at 5 months of age or standard titer at 10 months of age. Finger prick blood samples were tested for measles antibody 5 to 7 years later by the hemagglutinin inhibition test. RESULTS: Persistence of antibody after high titer vaccines was poor with the result that 39 and 50% of the EZ-HT and the SW-HT groups had low titers of hemagglutinin inhibition measles antibodies (< or =125 mIU/ml). Nineteen percent of the children in the SW-STD group had low titers which is a lower prevalence than in the high titer groups [relative risk (95% confidence intervals), 0.05 (0.28 to 0.88) vs. EZ-HT; relative risk, 0.38 (0.22 to 0.66) vs. SW-HT]. Geometric mean (95% confidence interval) antibody titers in children with detectable values were 616 (435 to 871) in the EZ-HT, 1106 (616 to 1866) in the SW-HT and 1271 (871 to 1741) mIU/ml in the SW-STD groups, respectively. Multivariant regression analysis showed that mean titers were 2.00 (1.03 to 3.89) times higher for children with low prevaccination antibody titers (< or =125 mIU/ml) and 3.06 (1.90 to 4.94) times higher if blood was collected in the rainy season. INTERPRETATION: Given the rapid decline in antibody titers over a 5- to 6-year period in an area where measles vaccine coverage was high, it seems likely that multiple dose immunization schedules will be needed in the future to maintain protective antibody concentrations (>125 mIU/ml) in West Africa. The role of subclinical boosting by exposure to natural measles and the possible role of malaria, which increases immunoglobulin turnover, in influencing long term antibody persistence after vaccination deserve further investigation. PMID- 9951982 TI - The natural history of human immunodeficiency virus 1 infection in Haitian infants. AB - OBJECTIVES: The current study followed HIV-infected women through pregnancy and their infants through the first 2 years of life to determine the rate of vertical transmission of HIV infection from Haitian women, factors in maternal health and obstetrical history that might influence such transmission and the natural history of HIV infection in their affected offspring. STUDY DESIGN: The medical histories of 81 infants born of HIV-infected women and of a control group of 88 infants born to uninfected women were documented with close clinical and serologic follow-up. In addition to standard tests for persistence of HIV antibodies, the use of acid-dissociated p24 assays enabled us to assign some additional infants to the HIV-infected cohort. RESULTS: Transmission could be documented in 27% of infants born to HIV-infected women. Excess early deaths occurred in infants of HIV-infected women in Port-au-Prince with 60% of infected infants dead by 6 months of age. This is a more accelerated mortality than that in a group of 42 HIV-infected infants born of Haitian mothers living in Miami where 10% were dead at 6 months. Clinically, in 6 of 19 deaths in HIV-infected children in Haiti, failure to thrive and gastroenteritis lead to a systemic infection manifested as meningitis, sepsis or pneumonia as the immediate cause of death. CONCLUSIONS: Early mortality attributable to perinatally acquired AIDS was identified in Haiti. The comparison of data from Miami and Port-au-Prince suggests that environmental exposures in developing countries may be more operative in this early mortality than viral strain or maternal host factors, both of which might be expected to be similar between the two groups of Haitian ethnicity. PMID- 9951983 TI - Changes in epidemic patterns of Kawasaki disease in Japan. AB - OBJECTIVE: Clustering of cases of Kawasaki disease throughout Japan was noted three times during the period before 1986. During the ensuing 10 years, however, no nationwide epidemic has been recognized. The purpose of this study is to test the hypothesis that local outbreaks have persisted after 1987. METHOD: The data on 56 980 patients reported from 1987 through 1996 were classified according to the area of residence. The time trend of the incidence rate was compared by year and by quarter of the year (January to March, April to June, July to September and October to December) in 10 geographical areas in Japan. RESULTS: No nationwide outbreaks have been noted since 1987 in Japan, but the existence of local outbreaks of various magnitudes was recognized as occurring in different periods in certain areas. The incidence rates were continuously high in Area 1 between 1987 and 1988 and in Area 4 between 1995 and 1996. In Area 9 local outbreaks were noted on three separate occasions (from 1987 to the first half of 1988, between 1990 and 1991 and from the second half of 1992 to 1993). No clusterings were witnessed in other areas during the 10-year period. CONCLUSION: The current annual number of patients ranges from 5000 to 6000, and local epidemics occur in various areas. The current epidemiologic patterns support the infection theory for the etiology of this disease. PMID- 9951984 TI - Update on hepatitis C for the general pediatrician. PMID- 9951985 TI - Periodic fever syndrome. PMID- 9951986 TI - The etiology of Kawasaki disease: superantigen or conventional antigen? PMID- 9951987 TI - Viral causes of tonsillitis and fever unresponsive to antibiotic therapy. PMID- 9951988 TI - Demonstration of Chlamydia pneumoniae in cardiovascular tissues from children with Kawasaki disease. PMID- 9951989 TI - Visceral leishmaniasis treated with liposomal amphotericin B. PMID- 9951990 TI - Beta-hemolytic Streptococcus milleri group misidentified as Streptococcus pyogenes on throat culture. PMID- 9951991 TI - A suspected case of trimethoprim-sulfamethoxazole-induced loss of fingernails and toenails. PMID- 9951992 TI - Group B streptococcal disease in a child beyond early infancy with a deficiency of the second component of complement (C2). PMID- 9951993 TI - Fever, thrombocytopenia and splenomegaly in a neonate. PMID- 9951994 TI - Use of metronidazole during pregnancy. PMID- 9951995 TI - Case definition for dengue hemorrhagic fever. PMID- 9951996 TI - Comparison of three rapid, in-office mononucleosis tests. PMID- 9951997 TI - Saying no thanks to life extension by tube or device. PMID- 9951998 TI - Progress in the determination of histocompatibility. 1965. PMID- 9951999 TI - Ex vivo evaluation of organ function after cold ischemia. AB - An ex vivo perfusion of kidneys was performed at 34 degrees C after cold ischemia of 24, 48, 72, and 96 hours to evaluate organ function prospectively. The prospective evaluation of organ function followed static hypothermic storage of the kidneys in a solution representative of clinical organ preservation. The warm perfusion was performed with an acellular solution that supports oxidative metabolism of sufficient magnitude to restore urine flow ex vivo. The parameters of organ function evaluated included oxygen consumption, vascular resistance, urine flow, and glomerular filtration rates, which were correlated with the histologic findings. The results of this study suggest that kidneys exposed to 24 and 48 hours of cold ischemia demonstrated oxygen consumption rates and vascular dynamics similar to control kidneys without exposure to cold ischemia, indicating cell viability. When the cold ischemic period was increased beyond 48 hours of preservation, substantially reduced rates of oxygen consumption and increased vascular resistances were observed, representing a loss of viability confirmed histologically. However, organ function was found to be impaired after exposure to cold ischemia at every time point. These results suggest that cold ischemic exposure had a negative impact on immediate renal function once oxidative metabolism was restored, which was exacerbated as the cold ischemic period was extended. Furthermore, these findings suggest that although the renal cells were viable after cold ischemic exposure, the viability status did not result in immediate function. Therefore, assessment of an organ based solely on cell viability may falsely indicate a functional organ. It will be necessary to identify parameters of organ function that can distinguish reversibility from non reversibility of cellular impairment to distinguish permanent functional disturbances. The ability to predict organ function prospectively will be an important aspect of any effective future expansion of the organ donor pool. PMID- 9952000 TI - Bioartificial pancreas use in diabetic pregnancy. AB - The purpose of this study was to evaluate the feasibility and effectiveness of Bioartificial Pancreas (BAP) technology use during diabetic pregnancy. In particular, the study asked 1) can microencapsulated islet cells effectively correct carbohydrate metabolism during diabetic pregnancy and 2) will such therapy, if initiated before conception, eliminate diabetes-induced congenital malformations in the fetus? Streptozotocin-induced diabetic female mice (ICR) received transplants of rat islets encapsulated within alginate microbeads. Animals were placed with male mice and bred. Random, nonfasting blood glucose (BG) determinations were made posttransplantation and throughout pregnancy. Pups were delivered by cesarean section on day 19 of gestation. Outcome parameters from transplanted animals (Tx) were compared to nondiabetic control animals and to untreated diabetic (DM) animals. Transplanted animals had significantly lower BG levels throughout pregnancy, compared with DM animals, but also had levels that were often lower than those seen in control nondiabetic animals, and had increased episodes of documented hypoglycemia. The malformation and fetal loss rate in the Tx group was significantly lower than the untreated group (ICR: 5.4% vs. 40%). Only 3 of 84 pups from the Tx group had major malformations, but all had anencephaly, a malformation not seen in any other study group. Both maternal BG levels and fetal malformation rates are significantly reduced using BAP technology in our animal models. However, the possible role these encapsulated islets may play in producing increased episodes of hypoglycemia or specific congenital malformations in pregnancy must be thoroughly investigated before any clinical studies. PMID- 9952002 TI - Fluid dynamic optimization of a ventricular assist device using particle image velocimetry. AB - Thrombus formation and resulting thromboembolism are major risks that can impede the widespread use of ventricular assist devices (VADs). Adverse flow patterns (turbulence and stasis) have been implicated in thrombogenesis. This study focuses on optimization of VAD geometry, port orientation, and fluid dynamics to reduce thrombus formation. Particle image velocimetry with cross-correlation was performed using Amberlite particles suspended in distilled water. The transparent VADs were illuminated by halogen lamps. Four different VADs were tested in an iterative approach toward optimization. A peak shear stress of 9,100 dynes/cm2 was noted in the first configuration immediately after the end of systole at the outlet port. Modifications in chamber geometry, port diameters and orientation, and valve enclosure design yielded shear stresses in the two subsequent geometries of 5,100 dynes/cm2 and 1,900 dynes/cm2, respectively. For the third iteration, a region of stasis occurred during the transition between the inlet port and the blood chamber. Further modifications were implemented, including a reduction in port diameters and further smoothing of the port entry region. This eliminated stasis and yielded a maximum shear level of 4,100 dynes/cm2. In conclusion, optimization was achieved through geometric modification of the VAD, thus minimizing adverse flow conditions. PMID- 9952001 TI - Theoretical prediction of the hemodynamic performance of slow resorbing polyester protein impregnated arterial prostheses after implantation: a plea for fast resorption of the coating. AB - The clinical literature cites cases where slow, incomplete, or nonuniform protein resorption from protein impregnated arterial prostheses produces undesirable localized internal capsule proliferation leading to a significant reduction of the internal diameter of the prosthesis. In an attempt to describe the hemodynamic response to this phenomenon, the blood flow in such stenotic regions was simulated and characterized numerically using FIDAP computational fluid dynamics software to determine the Navier-Stokes and continuity equations for simple channel flow. To simulate various stages of internal capsule development, numeric computations were made in an idealized tubular expansion at stenosis ratios ranging from 0.9 to 0.5 and stenosis length ratios from 10 to 40. The results indicated that a triangular annular ring vortex was formed immediately distal to the stenosis at all Reynolds numbers (Re) studied. The size of the vortex increased almost linearly with the Reynolds number. The pressure drop through the stenosis was affected by blood flow rate, severity, and stenosis length. When the stenosis ratio was low, the pressure drop through the stenosis increased gradually and almost linearly with blood flow rate. In a severe stenosis, the pressure drop was no longer a linear function of flow rate, but increased significantly with increasing flow rate. In conclusion, satisfactory healing of the internal capsule requires fast resorption of any impregnated protein. If the resorption is slow, incomplete, or nonuniform, there is a tendency for the lumen to narrow, causing stenosis, an increased pressure drop through the narrowed graft and disturbed flow distal to the stenosis. This phenomenon therefore constitutes a major limitation for using this type of graft in small diameter arterial reconstruction. PMID- 9952003 TI - Extracorporeal recording of mouse hemodynamic parameters by ultrasound velocity dilution. AB - The use of mice as models for cardiovascular studies has traditionally been difficult because of their small size and the lack of appropriate instrumentation to perform fundamental measurements of cardiac output (CO) and total blood volume (TBV). The advent of transgenic techniques to develop mouse strains that mimic human disease makes the development of this instrumentation crucial. The current study outlines a novel technique for the determination of CO and TBV in the mouse using an extracorporeal arteriovenous (A-V) shunt, combined with the measurement of ultrasound dilution after the intravenous administration of small volumes of isotonic saline. The potential sources of error associated with Stewart-Hamilton dilution techniques were addressed by the research. The new techniques were applied in three anesthetized mice (27-36 gm). Isotonic saline (10-80 microl) was injected intravenously while measuring ultrasound dilution in the A-V shunt. The CO ranged from an average of 6.8+/-0.71 to 12.7+/-1.7 ml/min. Heart rates were not significantly altered by the intravenous administration of isotonic saline. The TBV ranged from 4.36+/-0.22 to 5.15+/-1.04 ml/100 gm. These results agree with the literature and suggest that these techniques will prove useful in cardiovascular studies of mice. PMID- 9952004 TI - Promotion of neovascularization around hollow fiber bioartificial organs using biologically active substances. AB - A limiting factor of the long-term function of bioartificial organs is oxygen delivery to the encapsulated tissue. This study determined whether incorporation of endothelial cell growth factor (ECGF) into the alginate core of a hollow fiber bioartificial organ will induce neovascularization around the hollow fiber. Polyethersulfone (PES) and polyvinylidine difluoride (PVDF) hollow fibers were examined. Endothelial cell growth factor was incorporated into sodium alginate, extruded into the lumen of hollow fibers, and cured in calcium chloride. Samples without ECGF were fabricated and used as controls. Hollow fibers were implanted into 16 rats. For each rat, two implants were placed subcutaneously and two intraperitoneally, one with and one without ECGF at each site. Implants were placed on opposite sides of each animal. Implants were removed 65 days later and examined using immunohistochemical methods and light microscopy to determine the extent of neovascularization. A total of 64 implants were used. Most intraperitoneal implants were found free floating but were encased within a 100 microm thick avascular fibrotic reaction. This finding was independent from the presence of ECGF. Hollow fibers without ECGF, implanted subcutaneously, also had an avascular fibrotic reaction surrounding each implant. Subcutaneous implants with incorporation of ECGF within the alginate core had marked neovascularization within the fibrotic overgrowth that surrounded these implants. This was most prevalent in hollow fibers, with the thin separation layer facing the fiber lumen irrespective of limiting pore size. Potent angiogenic factors, such as ECGF, incorporated into diffusion chamber bioartificial organs can promote neovascularization around the subcutaneously implanted hollow fiber and may improve oxygen delivery to the tissue encapsulated within devices based on this technology. PMID- 9952005 TI - Intravascular membrane oxygenator and carbon dioxide removal devices: a review of performance and improvements. AB - The first intravascular oxygenator and carbon dioxide (CO2) removal device (IVOX), conceived by Mortensen, was capable of removing 30% of CO2 production of an adult at normocapnia with a measurable reduction in ventilator requirements. Through studies of mathematical modeling, an ex vivo venovenous bypass circuit to model the human vena cava, animal models of severe smoke inhalation injury, and patients with acute respiratory failure, the practice of permissive hypercapnia has been established to enhance CO2 removal by IVOX. By allowing the blood pCO2 to rise gradually, the CO2 excretion by IVOX can be linearly increased in a 1:1 relationship. Experimental and clinical studies have shown that CO2 removal by IVOX can increase from 30 to 40 ml/min at a normal blood pCO2 to 80 to 90 ml/min at a pCO2 of 90 mm Hg. In addition, IVOX with permissive hypercapnia allows a significant reduction in minute ventilation and peak airway pressure. Active blood mixing to decrease the boundary layer resistance in the blood can significantly improve O2 transfer by up to 49% and CO2 removal by up to 35%. Design changes can also improve the performance of IVOX. Increased surface area with more fibers and enhanced mixing by increased fiber crimping in new prototypes of IVOX significantly increased CO2 removal. Other groups have used alternative designs to address the limited performance of intravascular gas exchange devices. With improved design and patient management, clinically meaningful gas exchange and reduction in mechanical ventilatory support may be achieved during treatment of severe respiratory failure. PMID- 9952007 TI - Significant reduction in circuit pressure with modified plasma separation chamber for a heparin removal device. AB - The heparin removal device (HRD), using plasma separation and poly-L-lysine (PLL) affinity adsorption, has been shown to be an effective alternative to protamine after cardiopulmonary bypass (CPB). Previous designs of the HRD used standard Luer-Lok ((phi = 2.3 mm) port connections between the extracorporeal tubing and the plasma separation chambers, which resulted in excessively high circuit pressures (> 750 mm Hg) at an HRD flow of 1,400 ml/min. To reduce circuit pressures, we enlarged the connection ports to phi = 4.2 mm, keeping other circuit components and sorbent amounts unchanged. The modified circuit HRD was divided into the SMALL PORT group (phi = 2.3 mm, A = 4.15 mm2) and the LARGE PORT group (phi = 4.2 mm, A = 13.85 mm2) in adult swine (70+/-5 kg) given 300 U/kg heparin. A dual lumen cannula was inserted into the right atrium and connected to the HRD. Inlet pressure ranged from 749+/-42 to 795+/-57 mm Hg in the SMALL PORT group during the HRD run at 1,400 ml/min, whereas it ranged from 345+/-5 to 372+/ 34 mm Hg in the LARGE PORT group (p < 0.01 between groups). Likewise, the chamber pressure ranged from 447+/-21 to 452+/-27 mm Hg in the SMALL PORT group and from 190+/-14 to 204+/-19 mm Hg in the LARGE PORT group (p < 0.01 between groups). There were no significant differences in ACT between groups. We conclude that enlarged chamber ports significantly lower circuit pressures for the HRD without changing heparin removal capability. PMID- 9952006 TI - Can the clearance of tumor necrosis factor alpha and interleukin 6 be enhanced using an albumin dialysate hemodiafiltration system? AB - Patients with acute hepatic failure (AHF) have elevated levels of inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL 6). Recently, we have shown selective hemodiafiltration with albumin dialysis, as an extracorporeal liver support device (ECLVS), to be effective in the clearance of multiple toxins that are elevated in AHF. Our objective was to evaluate whether ECLVS would be effective in the clearance of TNF-alpha and IL-6. An in vitro continuous hemodiafiltration circuit was used with single pass counter current dialysis. A known amount of recombinant rat TNF-alpha and IL-6 was added to heparinized bovine blood and filtered across a polyalkyl sulfone hemofilter using matched filtration and dialysate flow rates. During 4 hours, the serial TNF alpha and IL-6 concentrations were measured in the circulating blood, and the content of each cytokine was calculated using mass balance. For each cytokine, clearance was determined for two dialysate groups at constant temperature and pH (group 1: dialysate = 0.9 normal saline, n = 5; group 2: dialysate = albumin 2 gm/dl, n = 5). Analysis of data was performed using ANOVA and Student's t-test. There was improved clearance of TNF-alpha and IL-6 when albumin was used in the dialysate (81+/-0.09% of the initial TNF-alpha and 77+/-0.04% of the IL-6 quantities) compared with when 0.9 normal saline was used as the dialysate (58+/ 0.14% of the initial TNF-alpha and 56+/-0.18% of the IL-6 quantities); p < 0.03. An ECLVS utilizing hemodiafiltration with albumin dialysis is more effective than conventional hemofiltration in the clearance of TNF-alpha and IL-6 and, therefore, may benefit patients with acute hepatic failure. PMID- 9952008 TI - Evaluation of a physiologic pulsatile pump system for neonate-infant cardiopulmonary bypass support. AB - An alternate physiologic pulsatile pump (PPP) system was designed and evaluated to produce sufficient pulsatility during neonate-infant open heart surgery. This hydraulically driven pump system has a unique "dual" pumping chamber mechanism. The first chamber is placed between the venous reservoir and oxygenator and the second chamber between the oxygenator and patient. Each chamber has two unidirectional tricuspid valves. Stroke volume (0.2-10 ml), upstroke rise time (10-350 msec), and pump rate (2-250 beats per minute [bpm]) can be adjusted independently to produce adequate pulsatility. This system has been tested in 3 kg piglets (n = 6), with a pump flow of 150 ml/kg/min, a pump rate of 150 bpm, and a pump ejection time of 110 msec. After initiation of cardiopulmonary bypass (CPB), all animals were subjected to 25 minutes of hypothermia to reduce the rectal temperatures to 18 degrees C, 60 minutes of deep hypothermic circulatory arrest (DHCA), then 10 minutes of cold perfusion with a full pump flow, and 40 minutes of rewarming. During CPB, mean arterial pressures were kept at less than 50 mm Hg. Mean extracorporeal circuit pressure (ECCP), the pressure drop of a 10 French aortic cannula, and the pulse pressure were 67+/-9, 21+/-6, and 16+/-2 mm Hg, respectively. All values are represented as mean+/-SD. No regurgitation or abnormal hemolysis has been detected during these experiments. The oxygenator had no damping effect on the quality of the pulsatility because of the dual chamber pumping mechanism. The ECCP was also significantly lower than any other known pulsatile system. We conclude that this system, with a 10 French aortic cannula and arterial filter, produces adequate pulsatility in 3 kg piglets. PMID- 9952009 TI - Effects of mechanical fatigue on the bending properties of the porcine bioprosthetic heart valve. AB - The mechanisms underlying the failure of porcine bioprosthetic aortic heart valves are not well understood. One possible explanation is that delaminations of the layered leaflet structure occur through flexion, leading to calcification and further delaminations, and finally resulting in valve failure. We investigated the changes in flexural rigidity of the belly of aortic valve cusps subjected to accelerated durability testing. We used three-point bending wherein a load was applied to the center of each specimen by a thin stainless steel bar calibrated to a known load-displacement relationship. Ten circumferential and 15 radial specimens from valves fatigued to 0, 50, 100, and 200 million cycles were flexed both with and against the curvature of the cusp. Linear beam theory was applied as a means to compare the relative bending stiffness between groups. Although specimens aligned to the circumferential direction were stiffer when bent against the cuspal curvature, the radial oriented specimens exhibited no bending directional dependence. Both the radial and circumferential specimens experienced a significant decrease in the bending stiffness with an increased number of accelerated test cycles. Overall, our results suggest that it is the fibrosa that experiences the greatest loss of stiffness with mechanically induced fatigue damage. PMID- 9952010 TI - Conductance artifacts in a novel in vitro model of ventriculothoracic electrical coupling. AB - The utility of open chest conductance (COND) ventriculography is limited by artifacts altering the relationship between COND and left ventricular (LV) volume. Pressure-COND loops often lean to the left during LV volume reduction by caval occlusion. Time varying alterations in the pericardial-LV contact area affect electrical coupling in the open chest during the cardiac cycle, producing COND artifacts. In this study, an open-mediastinum model was constructed. Components represented the LV, blood, pericardium, and thoracic contents. Varying ventriculothoracic coupling was simulated by changing the volume of pericardial saline (0, 30, 60 ml). Raw dual field COND was repeatedly (n = 20) compared with volumes of normal saline from 60 to 120 ml at 5 ml intervals. Groups were compared by linear regression and repeated measures ANOVA. Artifacts significantly (p < 0.01) altered parallel COND, indicated by the y-intercept, with the exception of 0 versus 30 ml. The slope constant also changed significantly, with the exception of 30 versus 60 ml. These results suggest that variable pericardial-LV contact can cause time varying artifacts in COND in the open chest. Therefore, posterior insulation may reduce artifacts in COND ventriculography and should be tested for this effect. PMID- 9952011 TI - Effectiveness of transaortic venting from a failing left ventricle during venoarterial bypass. AB - Insufficient unloading of the left ventricle (LV) is a limitation of percutaneous cardiopulumonary support (PCPS). We previously reported the unloading effect of transaortic catheter venting (TACV) during venoarterial bypass (VAB) in normal hearts. The aim of this study was to assess the effectiveness of TACV with VAB in a heart failure (HF) model. Seven adult mongrel dogs underwent TACV with VAB, and isolated LV failure was induced by multiple ligation of left coronary arteries. With standard hemodynamic monitoring, slope of the LV end-systolic pressure volume relationship (Emax; mm Hg/ml), aortic elastance (Ea; mm Hg/ml), LV stroke work (SW; 10(-4)J), preload recruitable stroke work (PRSW; 10(-4)J/ ml), LV pressure-volume area (PVA; 10(-4)J), and potential energy (PE; 10(-4)J) were assessed using a micro-tip manometer and a conductance catheter. In addition to evaluation of LV function, myocardial adenosine 5'-triphosphate (ATP) was measured in each condition. The TACV combined support significantly reduced LV total energy (PVA) and LV work (SW). The LV energetic charge (PE/PVA, myocardial ATP) was significantly increased by TACV. These results suggest that TACV might be an effective technique for LV recovery during VAB or PCPS in patients with severe heart failure. PMID- 9952012 TI - Numeric flow simulation for an innovative ventricular assist system secondary impeller. AB - The secondary impeller of the Cleveland Clinic Foundation Innovative Ventricular Assist System heart pump is designed to pump the blood from the journal bearing through the annulus back to the discharge to rejoin the main flow. It is crucial, however, that the amount of hemolysis and potential for thrombus formation is minimized. Based on our earlier computational fluid analysis of the initial design, an improved secondary impeller has been proposed. The objective of this work was to analyze the flow with the new impeller configuration by computational fluid dynamics and to find out where in the geometry hemolysis becomes high, as well as where the potential for thrombosis exists. The present work includes: 1) visualizing the 3-dimensional flow pattern in the secondary impeller cavity, 2) investigating the tip clearance effect, and 3) estimating the shear stress distribution as a measure for blood damage caused in the secondary impeller cavity. PMID- 9952013 TI - Hemodynamic effects of prostaglandins and catecholamines in graded reduction of pulmonary flow during venoarterial bypass in awake goats. AB - The roles of prostaglandins and catecholamines in the hypotensive hemodynamic change during cardiopulmonary support with a venoarterial bypass (VAB) were investigated in a series of chronic animal experiments of gradually reduced pulmonary arterial blood flow (PAF). The VAB system consisted of a pulsatile ventricular assist device, an artificial lung, and the right atrium uptake and descending aorta return cannulae in four adult goats weighing 49-51 kg. The PAF was adjusted to 50, 10, and 0% of the total systemic blood flow. Indomethacin, an inhibitor of prostaglandin production; phentolamine, an alpha-antagonist of catecholamine; and noradrenaline, an agonist of catecholamine were administered at each PAF condition. The mean aortic pressure (mAoP) and the systemic vascular resistance decreased in proportion to the decrease in PAF. Indomethacin increased the mAoP at all PAF conditions, indicating a relationship between prostaglandins and hypotension. Phentolamine decreased the mAoP at all PAF conditions, indicating a normal response of catecholamine receptors. However, noradrenaline increased the mAoP at 50 and 10% PAF, but did not appreciably increase the value at 0% PAF, indicating complete response of catecholamine receptors to endogenous catecholamines at 0% PAF only. In conclusion, prostaglandins play a substantial role in hypotension during VAB, and catecholamines may subsequently increase in compensation for extreme hypotension. PMID- 9952014 TI - Numeric modeling of the cardiovascular system with a left ventricular assist device. AB - A numeric model consisting of a lump-parameter cardiovascular system (CVS) model and a model for the Cleveland Clinic Implantable Ventricular Assist System (IVAS), a nonpulsatile rotary pump designed to augment the failing left ventricle, are described in this paper. The purposes of this study were to 1) observe the hemodynamic interactions between CVS and IVAS under various physiologic and pathophysiologic conditions running at different speeds; and 2) allow testing and optimization of various IVAS control algorithms. An existing numeric model of CVS (24 coupled differential equations, representing all cardiac chambers and systemic and pulmonary vasculature) was modified to add the IVAS pump as an auxiliary chamber between the left ventricle and aorta with pressure flow-speed characteristics derived from in vitro testing. Simulations were conducted for ventricles with normal and abnormal systolic and diastolic dysfunction at different exercise levels with the pump running at various speeds. Computer simulations show that 1) numeric modeling is useful for predicting hemodynamic response of CVS to IVAS in various circumstances; 2) IVAS results in normalization of cardiac output, especially in failing hearts, although with reduced pulse pressure; and 3) various control algorithms allowing adaptation of IVAS to physiologic demands of CVS could be developed based on the simulation study. PMID- 9952015 TI - Development of an endocardioscope for repair of an atrial septal defect in the beating heart. AB - The purpose of this study was to evaluate the possibility of surgical treatment of an atrial septal defect in the beating heart without cardiopulmonary bypass. The first step was to develop an endocardioscope that permitted observation of the inside of the beating heart. To visualize the inside of the beating heart, the tip of the endoscope was covered with a glass adapter. The endocardioscope was inserted through the right atrial appendage in eight beagles. The atrial septum, foramen ovale, coronary sinus, tricuspid valve, and chordae tendineae were identified without hemodynamic derangement. The second step was to attempt to close the foramen ovale with clips or staplers. We were able to close the foramen ovale with these devices, but a safer, easier device is needed. The endocardioscope we developed should prove to be a useful tool for minimally invasive surgical treatment of heart diseases, such as atrial septal defect. PMID- 9952016 TI - Effect of multivitamins on plasma homocysteine and folate levels in patients on hemodialysis. AB - Hyperhomocysteinemia is a risk factor for cardiovascular disease in patients on hemodialysis. Causes include genetic enzyme deficiencies, chronic renal failure, and vitamin deficiencies. Homocysteine correlates negatively with folate status. In patients on hemodialysis, supraphysiologic doses of B vitamins and folate reduce homocysteine by 26-33%. No study has examined the effect of a standard multivitamin (Nephro-Vite Rx), containing B vitamins and 1 mg of folate, on erythrocyte-folate (RBC-folate) and homocysteine in patients on dialysis. We examined RBC-folate and homocysteine levels in 11 stable chronic patients on hemodialysis, mean duration of dialysis 9.8+/-4.1 months, who were not on vitamin or folate supplements, and repeated these levels after 3 weeks of once daily Nephro-Vite Rx dosage. Plasma homocysteine levels fell by 23.7% from 27.8+/-5.9 to 21.2+/-6.6 micromol/L (p = 0.007), whereas RBC-folate levels rose 60% from 631.2+/-208.3 to 1007.5+/-423.7 nmol/L (p = 0.001). The optimum dose of B vitamins and folate remains to be established, and a clinical benefit from lowering homocysteine has not yet been demonstrated. In summary, a standard multivitamin such as Nephro-Vite Rx reduces plasma homocysteine levels and increases RBC-folate levels in patients on hemodialysis. Our results may have implications for the modification of cardiovascular risk in these patients. PMID- 9952017 TI - Theoretical comparison of filtration by the renal glomerulus and artificial membranes. AB - Improvement in filtration performance of artificial membranes will be possible if their structure mimics the renal glomerulus. Blood filtration with glomerular capillary and artificial membranes was, therefore, modeled to clarify the effects of their structure on filtration rates. Filtration rates were obtained by dividing membrane modules axially into a number of sections and using a calculus of finite differences. The modules were assumed to be composed of straight hollow fibers arranged in parallel, with a membrane surface area of 1.5 m2. The mean transmembrane pressure (TMP) was assumed to be too low for a protein gel layer to form on the membrane surface. A decrease in the inner diameter of membrane hollow fibers led to an increase in filtration rate because of an increased film mass transfer coefficient. A decrease in hollow fiber length also produced an increase in filtration rate because of decreased axial TMP drop. The glomerular capillary has a higher filtration rate than artificial membranes because of the low TMP drop and the low osmotic pressure at the membrane surface. Decreasing both the inner diameter and the length of the hollow fibers is effective in increasing the filtration rate at constant TMP. PMID- 9952018 TI - Development of a stopped flow reactor for the rapid, high sensitivity measurement of endotoxin concentration in dialysate. AB - Continuous measurement of endotoxin concentration in dialysate, using a separated endotoxin-specific limulus reagent, promises rapid measurement without the complex operating procedures of the limulus reagent. To achieve high sensitivity measurements in a short period of time, an improved system featuring stopped-flow operation was developed. To prevent dispersion of the limulus reagent and residence of reacting solution containing the limulus reagent in the system reactor, the circuit in the reactor was changed from a coil configuration to a straight line, and its length was reduced. An endotoxin test solution was supplied at 760 microl/min, into which 40 microl of limulus reagent was pulse injected. Flow was stopped at the point where the test solution entered the reactor. After the completion of the reaction, the solution was passed through a spectrophotometer and the relationship between reaction time and absorbance was determined. Peak tailing was less than that obtained by the conventional technique, good correlation was obtained from the peak height, and a decrease in sensitivity caused by broadening of the peak was suppressed. The lower detection limit of dialysate was 100 endotoxin units (EU)/L at a reaction time of 20 minutes, and 60 EU/L at 30 minutes. Change from the monitoring system to stop flow operation made high sensitivity monitoring of endotoxin concentration with a short reaction time possible. PMID- 9952019 TI - In vitro clotting technique for hemodialysis circuits. AB - Physiologic clotting of a dialysis circuit was achieved using an in vitro method. The closed loop method used a circuit filled with defibrinated bovine blood. To achieve clotting, a slow infusion (5-15 ml/hr) of ACD bovine plasma was performed. The rate and amount of infusion of the plasma allowed for careful control of the amount of clotting in the circuit and dialyzer. By varying these, a range of clotting (10-40% dialyzer volume reduction) was achieved in a timeframe of approximately 100 minutes. The results of the technique closely mimicked clinical examples of dialysis circuits in appearance. Residual blood clots were present in the venous drip chamber filter, in nonstreamlined areas of the bloodline (e.g., bond joint gaps), and throughout the dialyzer fibers and header space. As an additional check of clotting distribution, the performance of the dialyzers compared favorably with previously reported effects of reuse. Solute clearances decreased with the fiber bundle volumes (FBV) of the devices. Correlations of small molecular weight (MW) (urea, creatinine) clearances with FBV were linear, whereas middle MW (vitamin B12) clearances and the ultrafiltration coefficient (kUF) had nonlinear correlations. The results indicate that this clotting method can be used as a valuable tool for a qualitative in vitro assessment of a hemodialysis extracorporeal circuit. PMID- 9952020 TI - Rapid activation of the alternative pathway of complement by extracorporeal membrane oxygenation. AB - Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with severe respiratory distress syndromes. However, an inflammatory response has been observed with the use of this therapy. We measured complement activation in vivo in two adults receiving ECMO for acute respiratory distress syndrome (ARDS). Production of complement activation fragments C4d, Bb, iC3b, and SC5b-9 was determined using commercial ELISA kits. In both patients there was intense activation of complement that peaked 1 hour (mean SC5b-9 increase to 1135% of baseline) after the start of ECMO and occurred predominantly via the alternative pathway (Bb production). Early and acute complement activation may be responsible for the initiation of the inflammatory response that has been observed in patients treated with ECMO. PMID- 9952021 TI - Evaluation of microparticles released from an adsorber used for low density lipoprotein apheresis. PMID- 9952022 TI - Differential surface expression of HLA-DRB1 and HLA-DRB4 among peripheral blood cells of DR4 positive individuals. AB - Increasing interest in the functional consequences of differential expression of MHC class II molecules prompted us to examine the surface expression of HLA class II molecules on fresh peripheral blood mononuclear cells. Differential regulation of DR4 and DRB4 was shown for peripheral blood monocytes. In addition, DR4 expression is upregulated on B cells of patients suffering from chronic inflammation and is reduced under prednisolone-treatment. The expression levels of total DR molecules on a given cell type are almost identical comparing different haplotypes among non-RA controls, suggesting that the alpha-chain determines the level of surface expression. The present findings fit the hypothesis that the differential expression of HLA class II molecules is involved in regulation of the immune response and may thus contribute to determining susceptibility to immunological diseases. PMID- 9952023 TI - Activation of human Valpha24NKT cells by alpha-glycosylceramide in a CD1d restricted and Valpha24TCR-mediated manner. AB - Vact14NK(natural killer) T cells play an important role in controlling tumors or in preventing autoimmunity in the murine system. Valpha24NKT cells, the human counterpart of Valpha14NKT cells, may contribute to controlling the progression of autoimmune diseases in humans. These findings show the possibility that ligand(s) for these NKT cells can control the above-mentioned pathological conditions. Specific glycolipids such as alpha-galactosylceramide (alpha-GalCer) and alpha-glucosylceramide (alpha-GlcCer) have been identified as ligand(s) recognized by murine Valpha14NKT cells in a CD1d-restricted manner, but it remains unclear whether these glycolipids are ligand(s) for Valpha24NKT cells in humans. To determine whether alpha-glycosylceramide is presented by CD1d molecules in humans, we initially established a Valpha24NKT cell line specific for alpha-glycosylceramide using dendritic cell (DC) like cells from normal peripheral blood mononuclear cells (PBMC) in an autologous mixed leukocyte reaction (auto-MLR) system, and characterized the Valpha24NKT cell line. The Valpha24NKT cells were CD3+ CD4-CD8-Valpha24+Vbeta11+NKRP1A+ and specifically proliferated in response to alpha-glycosylceramide in CD1d-restricted and Valpha24TCR-mediated manner. The phenotypic and functional similarities between murine Valpha14NKT cells and human Valpha24NKT cells suggest that Valpha24NKT cells may play an important role in controlling tumors or in preventing autoimmunity as observed with Valpha14NKT cells. PMID- 9952024 TI - Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Valpha24-JalphaQ and gammadelta T cell receptor bearing cells. AB - The adult liver contains lymphocytes with a unique phenotypic distribution compared to blood and other organs. We have characterized a human lymphocyte population that exhibits dual T cell and natural killer (NK) cell phenotype and function, denoted natural T (NT) cells, in nine normal adult liver specimens. Flow cytometry revealed that up to 55% (mean 27%) of hepatic (but <6% of peripheral) CD3+ lymphocytes expressed CD56, CD161 and/or one or more of the killer inhibitory receptors (KIR) p58.1, p58.2, p70 and CD94. NK function was attributed to the CD3+CD56+ cells by the demonstration that hepatic, but not peripheral, CD3+ lymphocytes could be induced to lyse NK-sensitive K562 target cells, while CD56- cells from both compartments could not. Three color flow cytometric analysis of fresh hepatic cells indicated that CD3+CD56+ NT cells can be either CD8+, CD4+ or CD4 CD8-, they express alphabeta or gammadelta T cell receptors (TCR) and CD161 and KIRs, but rarely CD16. Hepatic NT cells predominantly express the mature/activated CD45RO and CD56dim phenotypes. Analysis of mRNA production by isolated NT cells indicated a preferential usage of the invariant CD1-restricted Valpha24-JalphaQ TCR. The presence of such large numbers of chronically activated NT cells provides compelling evidence that the liver has unique immunoregulatory functions. PMID- 9952025 TI - Tolerance of NK and LAK activity for HLA class I-deficient targets in a TAP1 deficient patient (bare lymphocyte syndrome type I). AB - NK cells recognize target cells that lack HLA class I molecules and lyse them, according to the 'missing self' hypothesis. It was previously reported that a TAP2-deficient patient with an HLA class I-deficiency, had a normal number of NK cells but that the lymphocytes of this patient had lost their NK activity against K562 cells. In this study, we investigated the HLA class I-recognizing NK receptor expressions and the NK and LAK activities of the lymphocytes of a TAP1 deficient patient. The patient had a normal number of NK cells. Although the lymphocytes showed LAK activity against class I expressing targets following IL 2, IL-12 and IL-15 stimulation for 3 days, neither NK nor LAK activity against targets lacking class I molecules was induced. The NK cells of the patient expressed class I-recognizing NK receptors, although the percentages of such cells were low. However, no differences were observed in the expression levels of inhibitory and activating NK receptors between lymphocytes of the patient and those of healthy controls, suggesting that the modulation of the NK receptor expression is not primarily responsible for this tolerance. These results also suggest that the lymphocytes of the patient are defective in the recognition of class I-deficient target cells in order to promote the induction of self tolerance. PMID- 9952026 TI - Donor cell induced CD69 expression and intracellular IL-2 and IL-4 production by peripheral blood lymphocytes isolated from kidney transplant recipients. AB - Flow cytometry assays, which measure CD69 activation and intracellular cytokine production, have been used to measure peripheral blood lymphocyte (PBL) responses to in vitro antigen exposure. In the present study, we show that, in healthy individuals and immunosuppressed kidney transplant recipients, CD69 expression and intracellular cytokine production by peripheral blood T cells compare favorably to thymidine uptake as a measure of PBL response to alloantigen in mixed leukocyte culture (MLC). Heparinized whole blood from 23 healthy individuals was incubated for 24-48 h with 3rd party allogeneic monocytes; blood from twelve kidney transplant recipients was incubated with monocytes from their kidney donor and with monocytes from unrelated individuals. The percentage of T cells expressing surface CD69 or intracellular IL-2 or IL-4 was determined by 3 color flow cytometry. We identified 5 donor-specific response patterns in our kidney transplant group. One transplant recipient was hyporesponsive; his cells did not express CD69 or produce IL-2 in response to either donor or 3rd party allogeneic cells. All other transplant recipients expressed CD69 and IL-2 in response to 3rd party allogeneic cells. Two had no response to donor cells (donor specific hyporesponsiveness), three had donor-specific anergy (CD69 expression without cytokine production in response to donor cells), five had a donor specific Thl response (CD69 expression and IL-2 production in response to donor cells), and one had a donor-specific Th2 response (CD69 expression and IL-4 but not IL-2 production in response to donor cells). Rapid measures of donor-specific hyporesponsiveness such as CD69 activation antigen expression and intracellular cytokine production may prove valuable in monitoring lymphocyte function and aid in the long-term management of kidney transplant recipients. PMID- 9952027 TI - Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus. AB - A human cDNA expression library that was used to investigate the nature of autoantigens recognized by the serum from a patient with systemic lupus erythematosus revealed the presence of antibodies directed against two transcriptional regulation protein: DEK, a site-specific 45 kD DNA binding protein, likely involved in signal transduction and transcriptional regulation, and a novel 28 kD protein that showed a 94% homology with murine ALY, a nuclear protein that plays a role in regulating the activity of TCRalpha enhancer complex. Whereas autoantibodies directed to epitopes on DEK are commonly found in patients with pauciarticular onset juvenile rheumatoid arthritis, autoantibodies against ALY have not been described and their occurrence has led to the cloning of the cDNA sequence of the first member of the human ALY family. PMID- 9952029 TI - Chromosome 6p-encoded HLA-DR2 determination discriminates migraine without aura from migraine with aura. AB - Segregation analysis indicates that migraine without aura (MWoA) and migraine with aura (MWA) have multifactorial inheritance, but involved genetic and environmental factors are largely unknown. A controlled study was performed to assess the HLA-driven liability to migraine and to verify if the heterogeneity between MWoA and MWA is HLA-linked. Forty-five migraine patients (31 MWoA, 14 MWA) and 53 healthy blood donors as controls, coming from the same geographic area, were studied. Tissue typing was performed using the standard complement dependent microlymphocytotoxicity technique for HLA Class I and by PCR-SSP (Sequences Specific Primers) typing for HLA Class II. Data emerging from the present study showed no altered distribution for HLA Class I A, B, C antigen frequency in migraine (MWoA, MWA) if compared to the control group. HLA Class II DR2 antigen showed a decreased frequency in MWA group if compared with both MWoA (p = 0.01) and control group (p = 0.039, RR = 0.21). These results seem to support the hypothesis of a protective role of DR2 antigen in MWA and provide additional basis for the proposed difference within MWoA and MWA. PMID- 9952028 TI - An endogenous retroviral long terminal repeat at the HLA-DQB1 gene locus confers susceptibility to rheumatoid arthritis. AB - Human endogenous retrovirus (HERV) long terminal repeat (LTR) elements contain regulatory sequences that can influence the expression of adjacent cellular genes, which may contribute to breakdowns of the immune function leading to autoimmune disease. Rheumatoid arthritis (RA) is associated with particular HLA DR/DQ haplotypes that modulate the pathogenesis of this autoimmune disease. We have therefore studied a solitary LTR element (DQ-LTR3) of the HERV-K family at the HLA-DQB1 locus for a possible disease association among 228 RA patients and 311 unrelated blood donors. The DQ-LTR3 was significantly more frequent among patients (76% vs 33%, OR = 5.07,p < 0.0001), with the majority of patients being heterozygous for the DQ-LTR3 (61% vs 22%, p < 0.0001). HLA-DRB1*04 positive patients did still differ for the presence of the DQ-LTR3 (88% vs 70%, OR = 3.03, p < 0.001), with an increase of both DQ-LTR3 homozygous and heterozygous patients, when compared to DRB1*04 positive controls (p = 0.0015). HLA-DR/DQ genotype analysis among HLA-DRB1*04 positive individuals revealed significantly more DQ-LTR3 homozygotes among HLA-DRB1*04-DQBI*03 homozygous patients (72% vs 27%, P = 0.015), and the number of DQ-LTR3 homozygous (23% vs 19%) and heterozygous (66% vs 53%) individuals was also increased among HLA-DRB1*04 heterozygous patients (p = 0.034). The presence of the DQ-LTR3 element increased both the relative risk and the positive predictive value for either DRB1*04 DQB1*03 positive/negative individuals when compared to the presence of HLA DRB1*04-DQB1*03 alone. In conclusion, these data suggest that this DQ-LTR3 enhances susceptibility to RA. PMID- 9952030 TI - A clonal culture assay for human cord blood lymphohematopoietic progenitors. AB - We describe a two-step clonal culture assay system for human lymphohematopoietic progenitors present in umbilical cord blood which are capable of differentiation along both myeloid and B-lymphoid lineages. Human cord blood CD34+ cells were plated in methylcellulose in the presence of stem cell factor (SCF), granulocyte colony stimulating factor (G-CSF), interleukin (IL)-7, and the murine stroma cell line, MS-5. The growing primary colonies were individually examined for their potentials to differentiate along both myeloid and B-lymphoid lineages by reculturing aliquots of the primary colonies in methylcellulose culture containing IL-3, G-CSF and erythropoietin (Epo), and on a monolayer of MS-5 in the presence of SCF and G-CSF. Approximately 10-15% of the primary colonies generated various combinations of myeloid cells and CD19+ sIgM+ cells. Subsequent studies using micromanipulated single CD34+ cells unequivocally demonstrated the clonal origin of the lymphohematopoietic progenitors. This culture system should prove valuable for elucidation of the mechanisms regulating early stages of human lymphohematopoiesis. PMID- 9952031 TI - Triplet repeat polymorphism in the MICA gene in HLA-B27 positive and negative caucasian patients with ankylosing spondylitis. AB - Previously, we reported a triplet repeat polymorphism in the transmembrane region within the MICA gene closely linked to HLA-B in a limited number of B27-positive Caucasian patients with ankylosing spondylitis (AS) (N = 48). In this study, we enrolled much more patients including some negative for B27, 162 AS subjects consisting of 140 B27-positive, and 22 B27-negative patients. The microsatellite allele consisting of 4 repetitions of (GCT/AGC) (A4 allele) was present at a significantly higher phenotype frequency in the patient group than in the ethnically matched control group (Pc < 0.000001). However, the frequency of the A4 allele was not significantly higher in the B27-positive and B27-negative patient groups, as compared to the B27-positive and B27-negative control groups, respectively. The higher phenotype frequency of the A4 allele in the patient group was supposed to be due to a strong linkage disequilibrium between the MICA and HLA-B genes. Thus, the possibility that the MICA gene is involved in the pathogenesis of AS can be excluded, supporting the hypothesis of a primary association of AS with HLA-B27. PMID- 9952032 TI - Nomenclature for Factors of the HLA system, update August 1998. WHO Nomenclature Committee for Factors of the HLA System. PMID- 9952033 TI - Nomenclature for Factors of the HLA System, update September 1998. WHO Nomenclature Committee for Factors of the HLA System. PMID- 9952034 TI - Ganglioside GM1 attenuates scopolamine-induced amnesia in rats and mice. AB - Some experimental evidence suggests that the beneficial effects of monosialoganglioside GM1 on learning and memory could be related to an improving effect in central cholinergic function. The present study investigates the effects of GM1 on the memory impairment induced by scopolamine in rats or mice tested in passive (PA) and discriminative avoidance (DA) tasks, respectively. Wistar EPM-1 male rats and Swiss EPM-M1 male mice were treated daily IP with 50 mg/kg GM1 or saline for 7 or 14 days, respectively. Twenty-four hours after the last injection, GM1-treated animals received 1 mg/kg scopolamine (GM1-SCO) and saline-treated animals received 1 mg/kg scopolamine (SAL-SCO) or saline (SAL-SAL) IP. Twenty minutes later, the animals were submitted to PA or DA conditioning, and tests were performed 24 h later. The latency in entering the dark chamber of the PA apparatus (LD) presented by SAL-SCO rats was significantly decreased when compared to that presented by SAL-SAL animals. GM1-SCO animals showed an increased LD when compared to SAL-SCO animals and were not significantly different from SAL-SAL rats. GM1-SCO and SAL-SAL (but not SAL-SCO) mice spent significantly less time in the aversive enclosed arm of the discriminative avoidance apparatus when compared to the time spent in the non-aversive enclosed arm. The results are consistent with the interpretation that GM1 attenuates scopolamine-induced amnesia. Although not eliminating the participation of other transmitter systems, the present study indicates a possible role of central cholinergic transmission in the action of this compound on learning and memory. PMID- 9952035 TI - Effects of test conditions on the outcome of place conditioning with morphine and naltrexone in mice. AB - Drug administration during test trials can increase the expression of place conditioning, offering an opportunity to determine the specificity of this enhanced response. Prior to training, Swiss-Webster mice spent similar durations in each of the distinctive compartments of a two-compartment box during three 900 s tests. During a 4-day conditioning period, daily injections of morphine (5-20 mg/kg, SC) or vehicle were differentially paired with one of two compartments of the box using an unbiased place conditioning procedure. Post-conditioning tests were conducted 2 and 3 days after the last conditioning day. Mice pre-treated during post-conditioning tests with vehicle did not show significant preference for the morphine-paired compartment when conditioned with morphine. Pretreatment with morphine (2.5-30 mg/kg, SC) led to a dose-dependent increase in time spent in the morphine-paired compartment. Post-conditioning tests in other groups of mice were conducted with heroin (0.1-3 mg/kg), fentanyl (0.01-0.3 mg/kg), cocaine (10-30 mg/kg) and pentobarbital (10-30 mg/kg), and results suggested that none of the tested drugs facilitated the expression of the morphine-conditioned place preference. In another experiment, naltrexone (0.1-10 mg/kg, SC) was administered as the conditioning drug. When tested with naltrexone (0.1-10 mg/kg), there was a dose-dependent avoidance of the naltrexone-paired compartment. Overall, the present data indicated that: (1) failure to exhibit place preference or place aversion when tested in a drug-free state does not imply the failure of conditioning procedure; and (2) effects of the morphine cue reinstatement during the post-conditioning tests appeared to be related to the unique pharmacological profile of the morphine stimulus. PMID- 9952036 TI - Repeated neonatal maternal separation alters intravenous cocaine self administration in adult rats. AB - Behavioural responses to psychostimulant drugs can be profoundly affected by early environmental influences. The aim of this study was to describe the effects of repeated brief separations of rat pups from their dams during the early neonatal period on cocaine self-administration behaviour as adults. Lister hooded rats exposed to a repeated maternal separation procedure (REMS) showed altered acquisition and maintenance of cocaine self-administration as adults, the effects being dose and gender-dependent. Overall, the patterns of acquisition of self administration across three doses of cocaine (0.05, 0.08 and 0.5 mg/injection) suggested a rightward shift in the acquisition dose-effect functions for the REMS animals relative to control animals. At 0.05 mg/injection, there was a retarded acquisition of cocaine self-administration in male and female neonatally separated rats. At 0.08 mg/injection there was a facilitated acquisition in female neonatally separated subjects. After establishment of stable self administration of the training dose, in the same cohort of subjects, rightward and downward shifts in the cocaine self-administration dose-effect functions were determined for female and male REMS subjects, respectively, relative to their controls. The dose-effect function for both female groups was shifted to the left of that of the respective male groups, although the lighter body weights of the females meant that they administered a higher unit dose per unit body weight than the males. Whereas male REMS subjects tended to self-administer less cocaine than the controls at the dose eliciting maximal responding (0.03 mg/injection) and to make fewer lever responses overall at each dose tested, female REMS subjects self administered significantly more cocaine than their respective controls at a dose of 0.03 mg/injection. There was no differential sensitivity to the rate-altering effects of the selective dopamine D2 receptor antagonist, eticlopride, or to the selective dopamine D1 receptor antagonist, SCH 23390. These data provide further evidence that altered early environment affects drug-taking behaviour in a developmentally specific and gender-specific manner, with the effects of neonatal separation contrasting with previously published data on the effects of post weaning isolation rearing. PMID- 9952037 TI - Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat. AB - The effect of a dopamine receptor antagonist on locomotor activity was examined during withdrawal from either self-administered or experimenter-administered cocaine. In the self-administration experiment, the locomotor response to a challenge injection of cis-flupenthixol was assessed in photocell cages at 4 h after the cessation of a 12-h cocaine self-administration session. Rats which had self-administered cocaine, and were challenged with cis-flupenthixol (0.05 mg/kg), were found to be hypoactive relative to controls. In the experimenter administered cocaine experiment, animals were given eight IP injections of 15 mg/kg cocaine over a 9.5-h period, for a total of 120 mg/kg. At 4, 8, and 24 h (tested in three separate groups of rats) after cessation of the eight injections, the locomotor response to a challenge injection of saline or cis flupenthixol was tested. Cocaine-treated animals displayed a dose-dependent, heightened sensitivity to the locomotor depressant effects of 0.05 mg/kg and 0.2 mg/kg cis-flupenthixol 4 h post-cocaine, whereas they did not show increased sensitivity to 0.05 mg/kg cis-flupenthixol 8 or 24 h post-cocaine. However, cocaine-treated animals displayed a mild hypoactivity 8 h post-cocaine. In a separate group of animals, a dose-response experiment was performed which indicated that a dose of cis-flupenthixol as high as 0.2 mg/kg was required to produce locomotor depression in cocaine-naive rats. The results of this study support clinical observations of dopamine antagonist-precipitated motor dysfunction in abstinent cocaine abusers, and lend further support to the hypothesis that alterations in dopaminergic neurotransmission consequent to prolonged cocaine exposure are partly responsible for some of the symptoms of cocaine withdrawal. PMID- 9952038 TI - Effects of continuous oral nicotine administration on brain nicotinic receptors and responsiveness to nicotine in C57Bl/6 mice. AB - The route of drug delivery is an important consideration in studies that evaluate the long-term bio-behavioral adaptations that occur in response to chronic drug administration. Continuous infusions (intravenous or subcutaneous) or intermittent intraperitoneal (or subcutaneous) injections are the most commonly utilized routes of chronic drug delivery in these studies. The purpose of the present study was to determine the effects of chronic oral nicotine exposure on sensitivity to nicotine and brain nicotinic cholinergic receptors in female C57Bl/6 mice. Mice were randomized to different treatment groups that received 2% saccharin, containing 0-200 microg/ml nicotine (free base). In preliminary experiments, radiotelemetry devices were implanted in the mice; consumption of the nicotine-containing drinking solution caused a significant increase in home cage nocturnal (but not diurnal) activity and also altered circadian alterations in body temperature. Oral nicotine exposure resulted in dose-related elevations in plasma levels of cotinine, a primary nicotine metabolite. Continuous exposure (30 days) to oral nicotine (200 microg/ml) resulted in the expression of significant tolerance to the locomotor depressant and hypothermic actions of acute nicotine challenge. This tolerance was accompanied by a significant increase in brain nicotinic receptor number assessed by quantitative auto radiography using [3H]-cytisine (alpha4 nAChr) and [125I]-alpha-bungarotoxin (alpha7 nAChr) as radioligands. These results suggest that chronic oral nicotine delivery to female C57Bl/6 mice results in behavioral and biochemical changes that resemble changes that occur following other routes of chronic nicotine delivery. PMID- 9952039 TI - Locomotor response to MDMA is attenuated in knockout mice lacking the 5-HT1B receptor. AB - 3,4-Methylenedioxymethamphetamine (MDMA) is a psychoactive drug of abuse which is increasingly popular in human recreational drug use. In rats, the drug has been shown to stimulate locomotion while decreasing exploratory behavior. MDMA acts as an indirect agonist of serotonin (5-HT) receptors by inducing 5-HT release by a 5 HT reuptake transporter-dependent mechanism, although it is not known which 5-HT receptors are important for the behavioral effects of the drug. In order to examine the role of specific 5-HT receptors, we assessed the behavioral effects of MDMA on knockout mice lacking the 5-HT1B receptor. Knockout animals show a reduced locomotor response to MDMA, although delayed locomotor stimulation is present in these animals. This finding indicates that the locomotor effects of MDMA are dependent upon the 5-HT1B receptor, at least in part. In contrast, MDMA eliminates exploratory behavior in both normal and knockout mice, suggesting that the exploratory suppression induced by MDMA occurs through mechanisms other than activation of the 5-HT1B receptor. To confirm these findings, we tested the effects of MDMA on the locomotor and exploratory behavior of wild-type mice pretreated with GR 127935, a 5-HT1B/1D receptor antagonist. These mice had an attenuated locomotor response to MDMA, but still exhibited the drug-induced suppression of exploration. PMID- 9952041 TI - Sensitization elicited by directly and indirectly acting dopaminergic agonists: comparison using neural network analysis. AB - The major aim of this work was to compare sensitized responses to amphetamine with those of apomorphine. This was done using both a univariant analysis of locomotor activity and a multivariant neural network analysis of five different behaviors. The neural network analysis compares the pattern of behaviors from a treated group to a set of patterns from control conditions and estimates the dose of drug in control conditions that best matches the pattern of behaviors of the treated group. Both methods indicated that repeated administration of 2.0 mg/kg amphetamine but not 0.5 mg/kg amphetamine resulted in sensitization to the administration of a 0.5 mg/kg amphetamine challenge given 10 days following the end of the sensitizing regimen. Both analyses indicated sensitization following repeated administration of 5 mg/kg apomorphine. Studies of cross sensitization were done using a neural network analysis that could distinguish patterns of behavior elicited by amphetamine from those elicited by apomorphine. Such studies indicated that apomorphine elicits an apomorphine-like response in animals sensitized to either apomorphine or amphetamine. In contrast, amphetamine produces an amphetamine-like response in animals sensitized to amphetamine and an apomorphine-like response in animals sensitized to apomorphine. The results indicate that neural network analysis may be a useful tool for analyzing drug effects on patterns of behavior. PMID- 9952040 TI - Effect of 5-HT2 receptor antagonists on a cranial nerve reflex in the rabbit: evidence for inverse agonism. AB - This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) reflex of the rabbit. The NM reflex was elicited by varying intensities of a tactile stimulus and the magnitudes of the elicited responses were measured at each intensity. Dose-response curves were obtained for the effects of several 5-HT2 receptor antagonists on response magnitude. d-Bro-molysergic acid diethylamide (BOL), LY-53,857 and ketanserin had no significant effect on the magnitude of the NM reflex, indicating that they are neutral antagonists. However, the 5-HT2 receptor antagonists ritanserin, MDL 11,939 and mianserin produced a significant reduction in response magnitude with no significant effects on response frequency, suggesting that they were acting as inverse agonists at the 5-HT2 receptor. The reduction in reflex magnitude produced by mianserin (10 micromol/kg) was fully blocked by BOL (5.8 micromol/kg), supporting the conclusion that mianserin was producing a reduction in reflex magnitude through an effect at the 5-HT2 receptor. The occurrence of inverse agonism suggests the possible existence of constitutive activity in vivo. We conclude that the 5-HT2 receptor (either 2A or 2C) plays an important role in motor function, perhaps by providing a tonic influence on motor systems. PMID- 9952042 TI - In vivo 123I IBZM SPECT imaging of striatal dopamine-2 receptor occupancy in schizophrenic patients treated with olanzapine in comparison to clozapine and haloperidol. AB - We investigated the degree of striatal dopamine-2 (D2) receptor occupancy in six schizophrenic patients receiving clinically effective antipsychotic treatment with olanzapine 10-25 mg/day in comparison to patients treated with clozapine 300 600 mg/day (n = 6) or haloperidol 5-20 mg/day (n = 10). 123I Iodobenzamide (IBZM) and single photon emission computerized tomography (SPECT) were used for the visualization of striatal D2 receptors. For the quantification of striatal D2 receptor occupancy, striatal IBZM binding in patients treated with antipsychotics was compared to that in untreated healthy controls (n = 8) reported earlier. Olanzapine led to a mean striatal D2 receptor occupancy rate of 75% (range 63 85). Haloperidol-treated patients showed dose-dependently (Pearson r = 0.64; P < 0.05) a significantly higher (P < 0.05) mean occupancy rate of 84% (range 67-94). During clozapine treatment, the mean D2 receptor occupancy of 33% (range < 20-49) was significantly lower than with olanzapine (P < 0.005). The higher striatal D2 receptor occupancy of haloperidol was correlated with the incidence and severity of extrapyramidal motor side-effects (EPS). No clinical relevant EPS occurred during treatment with olanzapine or clozapine. There was no correlation between the degree of striatal D2 receptor occupancy and clinical improvement. PMID- 9952043 TI - Effect of a tyrosine-free amino acid mixture on regional brain catecholamine synthesis and release. AB - We report the effects of a tyrosine (and phenylalanine)-free amino acid mixture on tyrosine levels, ex vivo catecholamine synthesis and in vivo catecholamine release in brain regions of the rat. Administration of a tyrosine-free amino acid load reduced tissue levels of tyrosine (-50% after 2 h) in all brain regions examined (frontal cortex, hippocampus, striatum). The tyrosine-free amino acid mixture also reduced DOPA accumulation: this effect was most marked in striatum ( 44%) and nucleus accumbens (-34%), areas with a predominantly dopaminergic innervation. Smaller decreases (-20-24%) were detected in other areas (cortex, hippocampus and hypothalamus). The effect on DOPA accumulation was prevented by supplementing the mixture with tyrosine/phenylalanine. The tyrosine-free amino acid mixture did not alter 5-HTP accumulation in any region. In microdialysis experiments, the tyrosine-free amino acid mixture did not consistently alter striatal extracellular dopamine under basal conditions but markedly, and dose dependently, reduced the release of dopamine induced by amphetamine. In contrast, the tyrosine-free amino acid mixture did not alter either basal or amphetamine evoked release of noradrenaline in hippocampus. Overall, these studies indicate that administration of a tyrosine-free amino acid mixture to rats depletes brain tyrosine to cause a decrease in regional brain catecholamine synthesis and release. Dopaminergic neurones appear to be more vulnerable to tyrosine depletion than noradrenergic neurones. PMID- 9952044 TI - Involvement of the medial geniculate body in prepulse inhibition of acoustic startle. AB - Prepulse inhibition of acoustic startle is the normal reduction in startle response to an intense auditory stimulus when this stimulus is immediately preceded by a weaker prestimulus. Previous studies have shown that several neuroanatomical structures and pathways in the brain are involved in the modulation of prepulse inhibition. In the present study, the functional importance of the medial geniculate body (MG) in the modulation of prepulse inhibition was investigated. To this end, in vivo brain microdialysis probes were used to infuse drugs locally into the MG of awake, freely moving rats simultaneously with startle response and prepulse inhibition measurements in the same animals. Intrageniculate infusion of the sodium channel blocker, tetrodotoxin, significantly reduced prepulse inhibition without affecting baseline startle amplitude. A similar effect was obtained after intrageniculate infusion of the GABA(B) receptor agonist, baclofen. In addition, intrageniculate infusion of muscimol, an agonist at the GABA(A) receptor complex, reduced prepulse inhibition, although this effect was obtained at a higher concentration of the drug compared to that of baclofen. These studies suggest that the MG is involved in the modulation of prepulse inhibition and that auditory signals relayed via the MG may be subjected to inhibitory control at this level, involving GABA neurotransmission. PMID- 9952045 TI - Differential effects of GABA(A) and GABA(B) agonists on sensitization to the locomotor stimulant effects of ethanol in DBA/2 J mice. AB - Contemporary theories of drug abuse suggest that behavioral sensitization plays an important role in addiction. However, few studies have examined the mechanisms underlying behavioral sensitization to ethanol. The present study examined the ability of THIP (2, 4, or 8 mg/kg) and baclofen (5.0, 6.25, or 7.5 mg/kg), GABA(A) and GABA(B) agonists, respectively, to prevent development of sensitization to the locomotor stimulant effects of ethanol (2 g/kg) in DBA/2 J mice. Ethanol was administered immediately before four 5-min activity trials conducted at 48-h intervals. Administration of ethanol on each of the four trials resulted in behavioral sensitization in control groups. While having few effects on activity when given alone, both GABA agonists completely blocked the acute stimulant response to ethanol on the first trial. Administration of THIP prior to ethanol on each trial failed to prevent development of sensitization. In contrast, all doses of baclofen blocked sensitization. Assessment of blood ethanol levels 15, 50 and 100 min after administration of ethanol indicated that baclofen did not change the pharmacokinetics of ethanol. These results indicate an important role for GABA(B) receptors, but not GABA(A) receptors, in development of sensitization to the locomotor stimulant effects of ethanol. PMID- 9952046 TI - Effects of benzodiazepine agonists on punished responding in pigeons and their relationship with clinical doses in humans. AB - Anxiolytic drugs generally produce anticonflict effects in both pigeons and rats, although relatively few anxiolytics have been examined in the pigeon and the procedure has not been as completely validated as the rat model. In this study, we examined the antipunishment effects of a variety of benzodiazepine agonists in pigeons and compared the relationship between their potencies to engender anxiolytic-like effects and their clinical doses in humans. In pigeons whose responding was maintained under a multiple FR30food:FR30food+shock schedule, the benzodiazepine agonists diazepam, flunitrazepam, alprazolam, chlordiazepoxide, lorazepam, flurazepam, bromazepam, medazepam, and clorazepate produced dose related increases in punished responding, and, with the exception of medazepam, decreased unpunished responding at higher doses. Potencies calculated from the percentage of pigeons showing significant increases in punished responding ranged from 0.081 to 11 mg/kg, and these potencies were invariably lower than those for decreases in unpunished responding by factors ranging from 2.2 to more than 14. The comparison of relative potencies of benzodiazepine receptor agonists in pigeons and humans revealed a high positive correlation (0.90, P<0.005), thus demonstrating the predictive validity of this preclinical animal model for anxiolytic benzodiazepines. The results agree with previous findings of robust anticonflict effects of benzodiazepine receptor agonists and extend further the pharmacological characterization to compounds that have not been examined previously in pigeons. PMID- 9952047 TI - The GABA(A) receptor antagonist picrotoxin attenuates most sleep changes induced by progesterone. AB - Progesterone has been shown to exert benzodiazepine-like effects on sleep, which suggests that they are mediated by an agonistic modulation of GABA(A) receptor functioning. To assess the involvement of GABA(A) receptors, we investigated the sleep responses to one dose of the GABA(A) antagonist picrotoxin (1.5 mg/kg) and progesterone (90 mg/kg), administered IP to eight rats alone and in combination, during the first 4 post-injection hours. Compared with vehicle, picrotoxin significantly delayed the latency to non-rapid eye movement sleep (non-REMS) and thereby decreased all sleep states, but barely affected the EEG activity within non-REMS. Progesterone significantly shortened non-REMS latency, increased pre REMS, depressed low-frequency EEG activity (< or = 8 Hz) and augmented EEG activity in the higher frequencies within non-REMS. Except for the changes in high-frequency EEG activity, picrotoxin attenuated all effects of progesterone. These findings support the notion that GABA(A) receptors play an important role in the sleep effects of progesterone. PMID- 9952048 TI - Effect of nociceptin on alcohol intake in alcohol-preferring rats. AB - The present study investigated the effect of nociceptin (NC), the endogenous ligand of the opioid-like orphan receptor ORL1, on ethanol intake in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats. Acute intracerebroventricular (i.c.v.) injection of 250 or 500 ng/rat of NC, just before access to 10% ethanol (offered 2 h/day), significantly increased ethanol intake. Subchronic (7 days) i.c.v. injection of 500 ng/rat of NC, given just before access to 10% ethanol (for 30 min/day), resulted in a progressive decrease in ethanol consumption. After the end of NC treatment, rats progressively recovered their usual ethanol intake. When NC, 500 or 1000 ng/rat, was tested versus the effect of ethanol in the place conditioning paradigm, NC significantly reduced the increase in time spent in the ethanol-paired compartment after conditioning. This finding suggests that NC reduces the rewarding properties of ethanol in msP rats; thus, they may respond to the acute NC administration by increasing their ethanol intake in an attempt to achieve the usual reinforcing effect of ethanol, whereas subchronic NC treatment may result in extinction of ethanol drinking. The results of the present study suggest that the brain NC mechanisms may represent an interesting target of pharmacological interventions for the treatment of alcoholism. PMID- 9952049 TI - Self-efficacy and participation in vigorous physical activity by high school students. AB - The relationship between physical activity self-efficacy and participation in vigorous physical activity by high school students is examined in this article. Self-efficacy is hypothesized to be positively related to participation in three settings (physical education class, other school-related activities, and outside of school). The effects of age, gender, perceived barriers, and actual barriers are also examined. The sample consists of 1,041 grade 9 and 11 students from a large Metropolitan Toronto school board. Factors derived from a previous (factor) analysis were used to examine the effects of self-efficacy, perceived barriers, and life strain (an actual barrier). The results of multiple regression analysis indicate that physical activity self-efficacy, despite external barriers (but not internal barriers), is predictive of physical activity participation in the hypothesized direction. Other results show consistent age and gender effects on physical activity participation and some support for the hypothesized relationship between perceived barriers and participation. PMID- 9952050 TI - Changing women: the narrative construction of personal change through community health work among women in Mexico. AB - A major premise of health education is that people can and do change their lives. Personal changes and the events that precipitate them are often told in a form of narrative and are accompanied by a new sense of oneself. This research draws on the study of narratives and women's community activism to explore processes of personal change in women's activism as community health workers in Mexico. The research is a case study based on in-depth semistructured interviews. Two major categories of narratives of change emerged: change of the self and little or no change. Within these categories, changes are defined as development of the self, becoming a new and different person, actualization of the self, and little or no change. Although women experience significant changes, their changes are based on normative female identities. Implications for the study of narratives and personal change in health education are discussed. PMID- 9952051 TI - Adolescent abstinence and condom use: are we sure we are really teaching what is safe? AB - This article reviews existing research on condom and abstinence method- and user failure rates, and the use of this research in determining sexuality education curricula. Latex condoms effectively prevent pregnancies and most sexually transmitted diseases or infections (STIs), with method-failure rates between 0.5% and 7%, but with user-failure rates between 12% and 70%. Total abstinence presumably has a method-failure rate of zero, but research on periodic abstinence indicates user-failure rates between 26% and 86%. No researchers have attempted to establish total abstinence user-failure rates. Abstinence-only curricula evaluations have demonstrated changes in adolescents' attitudes but little change in sexual behaviors. Comprehensive sexuality education curricula have demonstrated attitudinal changes and delays in adolescents' sexual activity. Since inconsistent use of either condoms or abstinence threatens adolescents' health, this article urges more scientific research on total abstinence user failure rates, better and clearer dissemination of research findings, and encourages funders to require educators to show thorough knowledge of research findings. PMID- 9952052 TI - Self-regulating childhood asthma: a developmental model of family change. AB - This article tests a model of self-regulatory development in which families' cognitive beliefs and behavioral skills for managing asthma symptoms emerge in four successive phases: asthma symptom avoidance, asthma acceptance, asthma compliance, and asthma self-regulation. Confirmatory factor analyses revealed that the hypothesized multiphase model provided the best factorial fit for phase items. Subsequent Guttman analyses of the families' phase scores revealed a high degree of sequential ordering. Finally, trend analyses of family phase differences revealed a significant negative linear relation with measures of asthma severity and a significant positive linear relation with physician care and concern measures, asthma regulatory measures, and beliefs in Western biomedical practices. Despite receiving primary care for asthma at a major metropolitan university hospital, 83% of the sample were classified as precompliant. The phase model of asthma self-regulatory development offers a qualitative approach for investigating the psychological determinants of asthma self-regulatory behavior. PMID- 9952053 TI - Exploring self-efficacy as a predictor of disease management. AB - Self-efficacy is posited in social cognitive theory as fundamental to behavior change. Few health behavior studies have examined self-efficacy prospectively, viewed it as part of a reciprocal behavioral process, or compared self-efficacy beliefs in the same population across different behaviors. This article first discusses self-efficacy in its theoretical context and reviews the available prospective studies. Second, it explores self-efficacy as a predictor of disease management behaviors in 570 older women with heart disease. Although the R2 statistics in each case were modest, the construct is shown to be a statistically significant (p<.05) predictor at both 4 and 12 months postbaseline of several disease management behaviors: using medicine as prescribed, getting adequate exercise, managing stress, and following a recommended diet. Building self efficacy is likely a reasonable starting point for interventions aiming to enhance heart disease management behaviors of mature female patients. PMID- 9952054 TI - Staging of dietary patterns among African American women. AB - This article describes the development of a behavioral staging algorithm for use in the Eat Well, Live Well Nutrition Program, a peer-delivered community-based program for African American women (N = 301). The authors examined whether increased frequency in performing low-fat eating behaviors and lower percentage calories from fat intake resulted as a participant moved through five stages of readiness to change each of five low-fat dietary patterns. Frequency of performing low-fat dietary behaviors was significantly different (p<.05) between four stages for the pattern of avoid fried foods, three stages for modify meats, and two stages for the patterns of substitution, avoid fat as seasoning, replacement. Percentage calories from fat were significantly different (p<.05) between four stages for the pattern of replacement, three stages for avoid fried foods and modify meats, and two stages for substitution and avoid fat as seasoning. Implications of these findings for the tailoring of community-based dietary programs are presented. PMID- 9952055 TI - Monitoring the dissemination of an educational protocol on pediatric asthma in family practice: a test of associations between dissemination variables. AB - Many asthma education programs aim at reducing morbidity. Now that effective programs are available, the next step is the nationwide dissemination to achieve morbidity reduction. A dissemination of a tested program has been undertaken in Dutch primary care, guided by the Diffusion of Innovation theory. It was hypothesized that greater awareness and concern and/or receptivity about asthma self-management would make it more likely that family physicians would adopt the program. Family physicians were considered more likely to adopt the program if they saw it as an improvement on their current way of providing education, as easy to use, and as having observable outcomes. It was expected that once the program had been adopted, and as it was being implemented, it would increasingly be perceived by its users as successful. Finally, more perceived success of performance was expected to be related to continued use. Both longitudinal and cross-sectional data largely confirmed the hypotheses. PMID- 9952056 TI - Personal responsibility for health? A review of the arguments and the evidence at century's end. AB - This article examines the continuing controversies regarding personal versus social responsibility for health as they are being played out at the turn of the century. Following a brief examination of the contested meaning of "personal responsibility for health" in recent historical context, attention is focused on the arguments for and against holding the individual to be primarily accountable for his or her health behavior. The paper then makes the case for more balanced, ecological approaches that stress individual responsibility for health within the context of broader social responsibility. The article concludes by briefly summarizing the Canadian approach to health promotion as a useful example of what such a balanced, ecological approach might look like. PMID- 9952057 TI - Trazodone and valproate in patients discontinuing long-term benzodiazepine therapy: effects on withdrawal symptoms and taper outcome. AB - Recent uncontrolled research suggested that trazodone and sodium valproate may be helpful in benzodiazepine (BZ) discontinuation. We therefore undertook a double blind study to assess whether trazodone and valproate, as compared to placebo, would attenuate withdrawal and facilitate discontinuation in BZ-dependent patients with a minimum of 1 year daily BZ use. Seventy-eight patients, taking a mean dose of 19+/-17 mg/day of diazepam (or its equivalent), were stabilized for several weeks on their BZ (16 diazepam, 25 lorazepam, 37 alprazolam) and then for 1-2 weeks, pretreated with trazodone, sodium valproate or placebo before being tapered at 25% per week. All treatments were continued for 5 weeks post-taper. BZ free status was assessed after 5 and 12 weeks post-taper. Neither trazodone nor valproate had any significant effect on withdrawal severity. Peak physician withdrawal checklist change from baseline to peak severity was 16.4 for trazodone, 18.04 sodium valproate and 18.24 placebo (F = 0.10; NS). Taper success rates were significantly effected by both active agents at the 5-week, but not 12 week, assessment. At 5 weeks post-taper, 79% of sodium valproate and 67% of trazodone, but only 31% of placebo patients were BZ-free (chi2 = 7.34; df 2; P<0.03). Major adverse events for trazodone were sedation and dry mouth, and for valproate, diarrhea, nausea and headaches. PMID- 9952058 TI - Polymorphisms of the dopamine D4 receptor and response to antipsychotic drugs. AB - The dopamine D4 receptor may be a site through which the clinical effects of antipsychotic drugs are mediated. Polymorphisms of a 48 base pair repeat in the third exon of the DRD4 gene code for different length segments in the third intracytoplasmic loop of the D4 receptor. The most common long (seven repeat) form of the D4 receptor has been shown in both physiologic and pharmacologic experiments to respond differently to dopamine agonists and antagonists than do shorter forms of D4. Thus, variants of D4 may partly determine patient response to antipsychotic drugs and, in particular, response to typical neuroleptics, which have a relatively low affinity for the D4 receptor, as compared to clozapine, which has a relatively high affinity for D4. DRD4 polymorphisms in the third intron were characterized in 28 patients with chronic psychosis who responded well to typical neuroleptics, 32 patients who responded well to clozapine, and 57 healthy comparison subjects. Patients responding to typical neuroleptics carried the allele for the long (seven repeat) form of the D4 receptor (allele frequency 8.9%) less frequently than patients responding to clozapine (allele frequency 23.4%, P = 0.046) or healthy comparison subjects (allele frequency 26.3%, P = 0.004). The results of this study suggest that inherited variants of D4 may explain some of the interindividual variation seen in patient response to different classes of antipsychotic medication. PMID- 9952059 TI - Smoking withdrawal, nicotine dependence and prepulse inhibition of the acoustic startle reflex. AB - The present study examined the relationship between nicotine dependence as measured by the Fagerstrom Tolerance Questionnaire (FTQ) and prepulse inhibition (PPI) of the acoustic startle reflex measured after overnight smoking withdrawal in a non-clinical population of male smokers with no history of psychiatric disorders or drug/alcohol abuse. It was found that smokers who scored high (>median) on the FTQ showed significantly less PPI as compared to those scoring low (20 mg/d led to transient urinary retention, paresthesia, and reduced motor strength in the lower extremities accompanied by gait disturbances. The IT treatment lasted for 861 days (of which 580 days were spent at home), until the patient's death, not related to the treatment. CONCLUSION: Intrathecal infusion of buprenorphine/bupivacaine provided satisfactory long-term pain relief in a patient with PSS-associated Raynaud's phenomena, skin ulcerations, and intractable ischemic pain. PMID- 9952102 TI - Intrathecal addition of morphine to bupivacaine. PMID- 9952103 TI - Intrathecal fentanyl and fetal bradycardia. PMID- 9952104 TI - Paravertebral somatic nerve block for outpatient inguinal herniorrhaphy. PMID- 9952105 TI - Postoperative analgesia following total knee arthroplasty: a study comparing spinal anesthesia and combined sciatic femoral 3-in-1 block. PMID- 9952106 TI - Splenic marginal zone B-cell and thymic T-cell lymphomas in p53-deficient mice. AB - The molecular pathology and histogenesis of lymphomas in 56 retired breeder male and 14 12-week-old male homozygous p53-deficient (p53-/-) mice (C57BL/6TacfBR [KO]p53 N4) were evaluated. Lymphomas were assessed by serial morphologic techniques, immunohistochemistry, flow cytometry, and analysis of T cell receptor (TCR) or immunoglobulin heavy chain (IgH) gene rearrangements. We found two common types of lymphomas. T-cell lymphomas arose in the thymus through a sequence of lymphocyte depletion, medullary hyperplasia, and unilateral lymphoma. Tumor cells were CD3+, CD90+, and usually TCRalpha/beta+ and possessed clonal TCRbeta gene rearrangements. Thymic lymphoblastic lymphomas (LL) were highly malignant and quickly metastasized to the splenic white pulp and liver, even when the thymus was only slightly increased in weight. In the spleen, a novel lymphoma was found. Marginal zone hyperplasia led to marginal zone lymphoma (MZL), a well differentiated lymphoma that usually expressed CD45R (B220) and CD5 at low levels and that had clonal IgH gene rearrangements. IgH gene rearrangements were also seen in spleens with marginal zone hyperplasias only. Hyperplastic and neoplastic marginal zone B cells expressed IgM at low to normal levels, as seen by FACS analysis and immunohistochemistry. These tumors only metastasized to the liver at a later stage, as they became less differentiated. Several mice had both types of tumors present in the spleen. Two B-cell lymphoblastic lymphomas of uncertain origin were also found. In this article, we discuss the possible mechanisms responsible for development of the lymphomas seen in these p53-deficient mice. PMID- 9952107 TI - Quantitative analysis and in situ localization of human telomerase RNA in chronic liver disease and hepatocellular carcinoma. AB - Telomerase is a specialized type of reverse transcriptase that catalyzes the synthesis and extension of telomeric DNA. High levels of telomerase activity have been detected in most hepatocellular carcinoma (HCC) tissues; very weak telomerase activity is, however, detected in approximately half of nontumorous chronic liver disease tissues. The purpose of this study was to investigate the possible source of this weak telomerase activity in these tissues using quantitative competitive reverse transcription (RT)-polymerase chain reaction (PCR) and in situ RT-PCR. Competitive RT-PCR indicated that the relative amount of human telomerase RNA (hTR) was significantly higher in chronic hepatitis or liver cirrhosis compared with the normal liver (p < 0.005), and in HCC compared with the normal liver (p < 0.001) and with chronic hepatitis or liver cirrhosis (p < 0.0001). In the normal liver tissue, hTR was detected by in situ RT-PCR in occasional sinusoidal cells and nuclei of occasional hepatocytes. In tumor-free liver or tumor-bearing liver, hTR was detected in sinusoidal cells, infiltrating lymphocytes, occasional proliferative bile ductal epithelial cells, and the nuclei of occasional hepatocytes. In HCC, hTR was detected in nuclei of all HCC cells as an intense signal and in sinusoidal cells. These results indicate that the amount of hTR increases in the nuclei of hepatocytes during hepatocarcinogenesis, and that the cells associated with the weak telomerase activity in approximately half of the nontumorous chronic liver lesions are mainly migrating lymphocytes and sinusoidal cells. PMID- 9952108 TI - Development and characterization of a monoclonal antibody specific for human basophils and the identification of a unique secretory product of basophil activation. AB - Despite increasing evidence that basophils can infiltrate into inflamed tissues during allergic reactions, determination of the extent of infiltration and elucidation of their role in allergic disease has been frustrated by the lack of reliable means for detecting this cell type in tissues. In the present study, we report on a new monoclonal antibody specific for basophils and on the initial characterization of the antigen it recognizes. Basophils were isolated from peripheral blood by Percoll density gradient centrifugation and a positive selection immunomagnetic procedure and injected into mice to produce monoclonal antibodies. A hybridoma clone, designated BB1, secreted antibody of the IgG2a isotype; this antibody bound selectively to basophils on immunocytochemistry but did not react with any other cell type or tissue structure, although it did stain a proportion of cells from the basophilic cell line KU812F. In sections of mixed populations of peripheral blood cells, similar numbers of cells stained with Alcian blue dye and BB1 over a wide range of basophil purity. BB1 antibody was effective in identifying basophils in sections of mixed cells or in tissues after fixation with ethanol, Carnoy's solution, or formalin. Staining of basophils with BB1 gave a granular appearance, although flow cytometry indicated that some antigen was also present on the surface of the cell. Activation of these cells with anti-IgE antibody or with the calcium ionophore A23187 provoked release of the antigen in parallel with that of histamine. BB1 antibody did not, by itself, stimulate histamine release. The molecular mass of the antigen was determined on Hedrick-Smith gels to be 124+/-11 kd. This new monoclonal antibody will be a valuable experimental tool in future studies, allowing the reliable detection of basophils in tissues of patients with allergic and chronic inflammatory disease; in addition, the antigen it identifies has potential as a unique marker of basophil activation. PMID- 9952109 TI - Increased expression of tissue inhibitor of metalloproteinase-1 and loss of correlation with matrix metalloproteinase-9 by macrophages in asthma. AB - Alveolar macrophages (AMs) can mediate tissue destruction and repair by synthesizing matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) as well as inflammatory cytokines, which regulate their production. Imbalances between these enzymes and inhibitors may contribute to the tissue damage and remodeling seen in inflammatory diseases. In this study, we examined the role of AMs in chronic asthma. We have previously demonstrated an increased production of MMP-9 by AMs in untreated asthmatic patients as compared with healthy subjects, and in asthmatics treated with inhaled corticosteroids and patients with chronic bronchitis. We now report on the expression of TIMP-1, the inhibitor of MMP-9, and compare the levels and the regulation by cytokines of both MMP-9 and TIMP-1. Enzyme and inhibitor were measured using an enzyme immunoassay and immunoprecipitation. TIMP-1 steady-state mRNA levels were measured using the RNase protection assay. AMs from untreated asthmatics were found to produce more TIMP-1 both at protein and mRNA levels than AMs from other groups. The release of TIMP-1 and MMP-9 from individual AMs was significantly correlated in control populations and the molecules mainly complexed to each other, whereas this was not true for untreated asthmatics, indicating an imbalance between MMP-9 and TIMP 1 production. In the latter population, TIMP-1 release was inhibited by an anti IL-6 antibody and MMP-9 release by anti-TNF-alpha, anti-IL-6, and anti-IL-1/beta antibodies. The imbalance of MMP-9 and TIMP-1 production, via the involvement of different cytokines, suggests that AMs may be involved in the abnormal repair observed in chronic asthma. PMID- 9952110 TI - Experimental colitis increases small intestine permeability in the rat. AB - Small intestine permeability is frequently altered in patients with Crohn's disease and is thought to play a pathogenic role. The aim of this study was to investigate the permeability and structure of small intestine tight junctions (TJ) in an animal model of chronic distal colitis. Seven days after colitis induction with trinitrobenzenesulfonic acid/ethanol, the duodenal and ileal TJ were studied by means of transmission electron microscopy using lanthanum nitrate, freeze fractures, and immunohistochemistry of occludin, ZO-1, and cingulin. Animals treated with intrarectal ethanol alone served as controls. In controls, 7.5% of duodenal and 9.6% of ileal TJ were permeable to lanthanum, whereas in colitis, permeability increased significantly (79.5% and 72.9%, respectively; p < 0.001, both segments compared with controls). In colitis, the percentage of "leaky" junctions in duodena as well as in terminal ilea correlated positively with the macroscopic colon damage score (p < 0.02 and p < 0.005, respectively). Freeze-fracture analysis and immunohistochemistry of cingulin and ZO-1 did not reveal any difference between control and treated animals, whereas the signal of the transmembrane protein occludin was found to be disrupted and irregular in both small intestine segments. Distal colitis induces an increase of TJ permeability throughout the entire small intestine, and the extent of alterations correlates with colonic damage. Alterations in the transmembrane protein occludin seem to be responsible for the observed changes. Further investigation is needed to elucidate the mechanism of TJ alterations by a remote focus of inflammation. PMID- 9952111 TI - CD34+ cells in human intestine are fibroblasts adjacent to, but distinct from, interstitial cells of Cajal. AB - Interstitial cells of Cajal (ICC) generate the pacemaker component of the gut and play important roles in the control of gut motility. The tyrosine kinase receptor Kit is an established marker for ICC. Recently, it has been reported that immunoreactivity for the sialomucin CD34 may be present on ICC in human intestine. Gastrointestinal stromal tumors express both Kit and CD34, suggesting that these tumors may derive from ICC. We characterized the distribution of CD34 immunoreactivity at the cellular level in the normal human gut, using double immunofluorescence immunohistochemistry and confocal microscopy. CD34 immunoreactivity identified previously unrecognized cells closely adjacent to, but distinct from, the Kit immunoreactive ICC. These CD34 immunoreactive cells expressed the fibroblast marker prolyl 4-hydroxylase-whereas ICC did not-and were also distinct from smooth muscle cells, glial cells, and macrophages. In the human gut, CD34 immunoreactivity is not expressed by ICC but by a population of fibroblasts, likely corresponding to the "fibroblast-like cells" described in previous ultrastructural studies. Our findings also challenge the hypothesis that stromal tumors originate from ICC. PMID- 9952113 TI - Abstracts. 1999 Annual Meeting United States and Canadian Academy of Pathology. March 20-26, 1999. San Francisco, California. PMID- 9952112 TI - The basic helix-loop-helix transcription factor dHAND, a marker gene for the developing human sympathetic nervous system, is expressed in both high- and low stage neuroblastomas. AB - Neuroblastoma is derived from the sympathetic nervous system and might arise as a result of impaired differentiation, retaining the neuroblastic tumor cells in the cell cycle. Thus, to understand the genesis of neuroblastoma, the study of mechanisms and genes regulating normal sympathetic development is of potential interest. The basic helix-loop-helix transcription factors human achaete-scute homolog-1 (HASH-1) and deciduum, heart, autonomic nervous system, and neural crest derivatives (dHAND) are expressed in the sympathetic nervous system of embryonic mice and chicken, with undetectable postnatal expression. By in situ hybridization technique, we show that dHAND was expressed by human sympathetic neuronal and extra-adrenal chromaffin cells throughout embryonic and fetal life, and was initially expressed in immature chromaffin cells of the adrenal gland. With overt chromaffin differentiation, dHAND was down-regulated. HASH-1, in contrast, was expressed in human sympathetic cells only at the earliest embryonic ages examined (Week 6.5 to 7). All examined neuroblastoma specimens (25/25) and all cell lines (5/5) had detectable dHAND mRNA levels. HASH-1 expression in tumor specimens was more restricted, although all cell lines (5/5) were HASH-1 positive. These results show that neuroblastoma tumors have retained embryonic features, suggesting that many neuroblastomas are blocked at an early stage of normal development when HASH-1 and dHAND are expressed. dHAND also appears to be a reliable and potentially useful clinical diagnostic marker for neuroblastoma, because expression was not dependent on tumor or differentiation stages and other pediatric tumors were dHAND-negative. PMID- 9952114 TI - Society for Pediatric Pathology. Annual Meeting, San Francisco, California. March 20-21, 1999. PMID- 9952115 TI - Management of multilevel cervical spondylosis with myelopathy. PMID- 9952116 TI - Intrathecal morphine delivered via subcutaneous pump for intractable pain in pancreatic cancer. AB - BACKGROUND: Pain secondary to unresectable pancreatic cancer is frequently severe and extremely difficult to control with traditional methods of analgesia. This retrospective study reports the analgesic effects of intrathecal morphine sulfate by implanted infusion pumps in nine patients with unresectable adenocarcinoma of the pancreas. METHODS: Nine patients were implanted over a 2-year period. Preoperative morphine i.v. equivalents were a mean of 81.51 mg/day, with a range of 20-140 mg/day. Patients were hospitalized for a trial dose of 1-2 mg of intrathecal Duramorph, 1 mg/ml, via lumbar puncture to assess whether adequate pain relief could be achieved and whether there would be drug-related side effects. RESULTS: All patients who received a trial dose experienced excellent pain relief, and subsequently underwent implantation of a lumbar subarachnoid catheter and infusion pump during the same hospitalization. The mean number of days from diagnosis to pump implant was 119, with a range of 3-587 days. The mean maximum daily dose was 21.28 mg, with a range of 3-73.10 mg. No patient experienced respiratory depression or excess sedation which prevented achievement of pain control. Minor supplemental narcotic use was documented in three of the nine patients. Assessment of pain control was made by the level of activity and the analog pain scale, with 0 being no pain and 10 being the worst pain imaginable. All of the patients experienced good to excellent relief of pain. The mean duration of intrathecal morphine sulfate use until death was 137.3 days, with a range of 52-354 days. CONCLUSIONS: This series of nine patients indicates that long-term administration of intrathecal morphine via implanted infusion pump in patients with pancreatic cancer is both efficacious and safe. All patients and their families reported an improved quality of life with an increased level of activity. PMID- 9952117 TI - Intrathecal morphine delivered via subcutaneous pump for intractable cancer pain: a review of the literature. PMID- 9952118 TI - Clinical results of the transoral operation for lesions of the craniovertebral junction and its abnormalities. AB - BACKGROUND: We treated 20 cases of craniovertebral junction lesions via a transoral approach. Developmental abnormalities of the craniovertebral junction accounted for 15 cases; there were 3 cases of tumor, 1 case of osteomyelitis, and 1 case of rheumatoid arthritis. METHODS: The transoral transpharyngeal approach was used in all cases. In 17 non-tumoral patients the anterior margin of the atlas and the odontoid process were resected. In one patient with a ventral clivus chordoma, both a transoral and a transnasal transsphenoidal approach was used for partial resection of the tumor mass. In two cases the median transpharyngeal approach was combined with a jaw-facial incision. In one case a metastatic adenocarcinoma, and in another a neurinoma of the accessory nerve straddling the posterior fossa and the pharyngeal region were removed. RESULTS: After operation four cases developed craniovertebral joint instability and required posterior cervical fusion or external fixation with a halo brace. Follow up ranged from 2 to 44 months. In most patients neurologic function slowly improved. One worsened, and one died of respiratory failure after operation. Two patients with malignant tumors died during the follow-up period. CONCLUSION: In patients with developmental malformations, transoral decompression will result in some neurologic improvement and arrest the progress of symptoms. Patients with tumors are likely to show a good neurologic outcome when transoral surgery is performed in the early stage of the condition. PMID- 9952119 TI - Craniocervical junction tuberculosis: a rare but dangerous disease. AB - BACKGROUND: Mycobacterium tuberculosis of the cervical spine is a rare but dangerous manifestation of extra-pulmonary tuberculosis. The clinical picture ranges from early, nonspecific, insidious symptoms to severe neurological complications and death, attributed to craniocervical junction instability and cervicomedullary compression. The different lines of management include antituberculous medication with traction and external fixation or adjunctive surgery (debridement and stabilization) in patients with severe or persistent neurological complications and/or vertebral instability. METHODS: We describe two patients with advanced craniocervical junction tuberculosis. The early clinical picture was nonspecific in Case 1 and obscured by psychiatric illness in Case 2. The detailed clinical and radiological findings, and the management, will be described. Involvement of the occipital condyles and foramen magnum, which has not been reported previously, will be demonstrated. RESULTS: Both cases underwent transoral biopsy, aspiration, and debridement of retropharyngeal abscess (granuloma). Histological and tissue culture studies proved the abscesses were tuberculous and anti-tuberculous medications were started. Case 1 showed complete resolution of the clinical and radiological findings. Case 2 developed cardiorespiratory arrest while in a halo jacket. He was resuscitated but remained quadriplegic and semiconscious; he developed nosocomial gram negative pneumonia. He was referred back to his local hospital where he died 1 year later. CONCLUSIONS: Tuberculosis is an infrequent but notable cause of cervicomedullary compression. It should be suspected in patients with infective spondylitis who are immunocompromised or reside in an area highly endemic for tuberculosis. Management strategies include antituberculosis medication, transoral biopsy and drainage of the abscess, traction and external fixation, posterior decompression, and internal fixation, according to the clinical and radiological findings. PMID- 9952120 TI - Cervical myelopathy due to migration of Torkildsen's shunt: case report. AB - BACKGROUND: Ventriculocisternal (Torkildsen's) shunts were used often in the past for the treatment of patients with obstructive hydrocephalus. Cisternal shunts may still be indicated in the management of syringomyelia. CASE DESCRIPTION: Presented is a case of a patient developing cervical myelopathy due to migration of a Torkildsen's shunt placed 30 years before. Initially thought to have a malfunctioning shunt, he then underwent removal of the catheter, which was demonstrated on magnetic resonance imaging (MRI) to be compressing the cervicomedullary junction. The patient improved slightly after removal of the catheter. CONCLUSIONS: Patients with cisternal shunts in whom a cervical myelopathy develops should be evaluated with MRI to rule out upper spinal cord compression caused by a migrated catheter. PMID- 9952121 TI - Multidisciplinary approach to traumatic intracranial aneurysms secondary to shotgun and handgun wounds. AB - BACKGROUND: Traumatic intracranial aneurysms (TICAs) may develop following gunshot injuries to the head. Management of these lesions often combines various aspects of microneurosurgical and endovascular techniques to safely repair or obliterate vessel defects. METHODS: We reviewed our experience over the last 18 years and identified five cases of intracranial aneurysms following gunshot and handgun wounds that were treated surgically and/or endovascularly. RESULTS: All patients had successful obliteration of their lesions using a variety of therapeutic modalities aimed at preserving neurologic function while at the same time eliminating the aneurysm from the circulation. CONCLUSION: Both microneurosurgery and endovascular surgery have important roles to play in the management of TICAs. In some cases, both methods can be combined to eliminate lesions and maximize patient recovery in a safe, efficient, and effective fashion. PMID- 9952122 TI - Skull osteolysis after mild head trauma: case report. AB - BACKGROUND: To our knowledge, there have been only two reported cases of patients with osteolytic skull lesions secondary to head trauma without concomitant skull fracture. METHODS: We present a case of skull bone lysis, not associated with skull fracture in a 20-year-old male, after mild head injury. During surgery, tumorous skull tissue of benign appearance was excised and primary cranioplasty was performed. RESULTS: The pathological examination showed an inflammatory reactive process within the bone lesion. Three years after surgery the patient was asymptomatic and studies did not show any new bone changes. CONCLUSIONS: The authors draw attention to this exceptionally rare condition, pointing out the necessity of surgical biopsy, contrary to some opinions. PMID- 9952124 TI - Small cell lung carcinoma causing epidural hematoma: case report. AB - BACKGROUND: Epidural hematoma usually stems from trauma, yet it may occur from other etiologies, including neoplasms. We present a case of small cell lung carcinoma with focal hemorrhagic central nervous system metastasis producing an epidural hematoma, and review the associated literature. CLINICAL PRESENTATION: A 67-year-old man was undergoing chemotherapy for small cell carcinoma of the lung. Acute neurologic deterioration resulted from a large parietal epidural hematoma of non-traumatic origin. INTERVENTION: The clot was evacuated via craniotomy with marked improvement in his clinical state. Metastatic tumor was present in the scalp, muscle, bone, and dura. No gross brain invasion was apparent. CONCLUSIONS: This case illustrates the wisdom of including metastatic disease in the differential diagnosis of intracranial hemorrhage. Even epidural hematoma may result from metastatic cancer. The prevalence of lung carcinoma and the aging of the population may produce an increased appearance of this phenomenon. Appropriate evaluation and rapid intervention will aid the patient in both the acute and long-term phases, and should improve the quality of survival. PMID- 9952123 TI - Malignant prolactinoma: case report and review of the literature. AB - BACKGROUND: Malignant prolactinomas are rare events. To date, only 14 patients with metastases in- or outside the central nervous system have been reported. CASE DESCRIPTION: We present a patient who developed a metastasis to the cauda equina, which is the first case documented with MRI. A giant prolactinoma in this 51-year-old man was partially removed by a transcranial approach. After radiotherapy and treatment with bromocriptine, the patient had a remission for 3 years. Thereafter, a sacral intraspinal tumor was diagnosed. Because of increasing prolactin levels not responding to bromocriptine and a radiologically suspected intrasellar tumor, we operated transsphenoidally first and found only fibrous tissue. We performed a sacral laminectomy and almost totally removed an intradural tumor. Histopathology and immunohistochemistry confirmed the diagnosis of a prolactinoma metastasis. The patient received radiotherapy and bromocriptine and has no evidence of recurrent tumor or metastases after a follow-up of 38 months, thus being the second reported patient with long-term remission of the disease. DISCUSSION: We review the literature on this topic and try to establish common features of the course of this rare malignant disease and the efficacy of therapy in the cases reported hitherto. PMID- 9952125 TI - Recovery of hearing after removal of a large jugular foramen schwannoma: report of two cases. AB - BACKGROUND: Although hearing loss is a common presenting symptom of jugular foramen schwannoma (JFS), recovery of hearing after tumor removal has rarely been reported. We report two cases of a large JFS presenting with severe hearing loss and recovering normal hearing after tumor removal. METHODS AND RESULTS: Two patients complaining of progressive hearing loss each proved to have a large JFS involving the posterior fossa. The hearing losses, which exceeded 90 dB, were not associated with dysfunction of the 9th, 10th, or 11th cranial nerves. Schwannomas were removed by a suboccipital retrosigmoid approach, preserving labyrinthine structures. The vestibulocochlear nerve, stretched and displaced rostrally by the tumor, was preserved with surrounding arachnoidal tissue. Soon after surgery, recovery of hearing began; normal hearing was restored within 3 months. CONCLUSIONS: In a case of JFS with severe hearing loss, normal hearing may be attainable by tumor removal using a retrosigmoid approach that preserves labyrinthine structures. The arachnoidal tissue separating the vestibulocochlear nerve from the schwannoma is important to hearing preservation. PMID- 9952126 TI - Intra-arterial papaverine for the treatment of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. AB - BACKGROUND: Intra-arterial papaverine (IAP) has been described as a treatment for cerebral vasospasm refractory to standard therapy. METHODS: We report a series of 15 consecutive patients with aneurysmal subarachnoid hemorrhage in which IAP was employed for the treatment of symptomatic vasospasm. All patients exhibited delayed ischemic neurologic deficits, focal cerebral hypoperfusion on stable xenon-enhanced computerized tomography cerebral blood flow studies, and angiographically defined arterial narrowing. Papaverine was infused into 32 arteries on 23 occasions. Six patients required multiple treatments between 1 and 8 days apart. In five instances, IAP was combined with angioplasty. RESULTS: Angiographically defined vasospasm was at least partially reversed immediately following treatment on 18 of 23 occasions. The associated clinical improvement was major on 6 occasions, and either minor or none on 17. Post-treatment cerebral blood flow was assessed on 13 occasions and showed improvement in previously ischemic areas on six occasions and no improvement on seven. Complications were encountered on four occasions. Systemic hypotension and transient brain-stem depression were seen with vertebral artery infusions; a generalized seizure and paradoxical aggravation of vasospasm resulting in hemispheric infarction occurred with internal carotid artery infusions. CONCLUSIONS: Intra-arterial papaverine resulted in reversal of arterial narrowing in the majority of cases (78%). However, this angiographic improvement was associated with cerebral blood flow augmentation in only 46% of cases analyzed, and major clinical improvement in 26%. PMID- 9952127 TI - Transluminal angioplasty and intra-arterial papaverine for the treatment of cerebral vasospasm after ruptured arteriovenous malformations. AB - BACKGROUND: This is the first report on the use of intra-arterial papaverine and percutaneous transluminal angioplasty in two patients with severe, symptomatic cerebral vasospasm who suffered ruptured arteriovenous malformations (AVMs). CASE DESCRIPTIONS: The source of hemorrhage was a venous aneurysm in the first case and a pedicular aneurysm of the distal posterior inferior cerebellar artery in the second case. In both cases, the AVMs were located in the superior vermis and there was minimal subarachnoid hemorrhage. The first patient underwent removal of the AVM before the period of cerebral vasospasm and the second patient underwent removal of the AVM after the cerebral vasospasm had resolved. The outcome was excellent in the first patient and poor in the second patient. CONCLUSION: Arteriovenous malformation with ruptured aneurysms may be at high risk for cerebral vasospasm even when there is minimal subarachnoid hemorrhage. We recommend early treatment of AVMs with ruptured pedicular, intranidal, or venous aneurysms to avoid rebleeding and to allow for aggressive treatment of cerebral vasospasm. The management of cerebral vasospasm after AVM rupture is discussed. PMID- 9952128 TI - Effect of clot removal and surgical manipulation on regional cerebral blood flow and delayed vasospasm in early aneurysm surgery for subarachnoid hemorrhage. AB - BACKGROUND: Effect of clot removal and surgical manipulation on cerebral blood flow (CBF) and delayed vasospasm was studied in early aneurysm surgery for subarachnoid hemorrhage (SAH). METHODS: Thirty-two patients in this study fulfilled the following criteria: ruptured anterior communicating aneurysms, computed tomography (CT) within 2 days and unilateral pterional approach within 3 days after the ictus, bilaterally symmetrical clots without intracerebral hematoma, no postoperative complication, and CBF studies with single photon emission computed tomography (SPECT) with 123I-IMP. RESULTS: Postoperative regional hypoperfusion due to brain retraction was frequently recognized on 123I IMP-SPECT without infarction. The regional CBF (rCBF) showed a continuous fall during the first 4 weeks after the ictus, followed by improvement. The rCBF in the vicinity of the surgical route was significantly lower, especially in the acute stage (Day 3-7). A significant association between decrease of cisternal blood after surgery and the degree of local vasospasm and local CBF values during spasm stage was observed in the interhemispheric cisterns, A2 and medial frontal cortex, but not in the sylvian fissure or insular cisterns, M1 or M2, and frontal watershed and temporal cortex. CONCLUSIONS: The present study provides evidence for the effectiveness of direct clot removal by early surgery for SAH on local vasospasm and CBF reduction. However, a potential improvement in local CBF with clot removal could be masked by brain retraction, which was demonstrated to affect rCBF adversely. Therefore, it is critical to perform brain retraction as gently as possible. PMID- 9952129 TI - Delayed thrombus propagation after parent artery clipping for giant fusiform aneurysms of the circle of Willis. AB - BACKGROUND: Obliteration of a giant fusiform aneurysm without significant therapeutic morbidity is extremely difficult. Ischemic complications have been often reported. METHODS: Two patients with giant fusiform aneurysms of the circle of Willis are presented. Both patients underwent proximal parent artery clipping after a bypass procedure. Balloon occlusion tests confirmed both patients' ability to tolerate flow reduction after proximal clipping. RESULTS: Although both patients awoke from anesthesia without neurologic deficit, they developed contralateral hemiparesis several hours after the operation as a result of a small infarct in the basal ganglia. These ischemic events might be attributed to the delayed thrombosis involving the orifice of the distal perforating arteries. CONCLUSIONS: In the treatment for giant fusiform aneurysms of the circle of Willis, special attention should be paid not only to flow reduction, but also to delayed thrombus propagation that may not be predicted by preoperative balloon occlusion testing. PMID- 9952130 TI - Recanalization of completely thrombosed giant aneurysm: case report. AB - BACKGROUND: Spontaneous recanalization in a completely thrombosed giant aneurysm is a very rare condition. CASE DESCRIPTION: An 18-year-old woman presented with a serpentine variety giant aneurysm of the posterior cerebral artery, in which spontaneous recanalization of a completely thrombosed lumen was demonstrated on magnetic resonance imaging and angiography. The patient was treated by trapping of the parent artery and aneurysmectomy. CONCLUSION: This case will provide insight into the potential for spontaneous recanalization in completely thrombosed giant aneurysms. PMID- 9952131 TI - Porcine small intestinal submucosa as a dural substitute. AB - BACKGROUND: The continuing search for the ideal dural substitute is currently directed toward collagen preparations. Xenogeneic porcine small intestinal submucosa (SIS), a naturally occurring extracellular matrix rich in collagen, has been successfully used as a soft tissue graft in several body organ systems, including preliminary studies as a dural substitute in the rat. METHODS: Eight dogs underwent temporoparietal craniotomy and dural resection with replacement by SIS. Five dogs had contralateral procedures without SIS grafting. Three dogs had contralateral SIS grafts placed 2 months after the initial procedure. Histologic assessment was obtained at 7, 30, 60, 90, and 120 days. Cerebrospinal fluid (CSF) cytological examination and routine serum chemistry preceded sacrifice. RESULTS: Histologic evaluation showed initial graft infiltration by mononuclear round cells, spindle-shaped cells within an eosinophilic staining extracellular matrix, and neovascularity. Complete resorption of the graft was evident by 60 days. This pattern is consistent with the previously described incorporation and remodeling of the SIS graft at other sites. CSF cytology and routine serum chemistry at the time of sacrifice were normal. Response to repeat grafting was identical to that of initial exposure. There was no clinical or histologic evidence of sensitization or graft rejection. No evidence of adverse effect on the underlying cerebral cortex was observed. CONCLUSIONS: Porcine small intestinal submucosa demonstrates a favorable biologic response as a dural substitute in the canine model. It is a promising biomaterial for dural replacement. PMID- 9952132 TI - Non-visualization of known cerebral aneurysm on MRA. PMID- 9952133 TI - The business of surgery. Business principles applied to preoperative planning, operating room management, and surgical strategy. PMID- 9952134 TI - Severe intraoperative CO poisoning: should apathy prevail? PMID- 9952136 TI - The role of spirometry in predicting pulmonary complications after abdominal surgery: progressing toward an answer. PMID- 9952135 TI - Surrogate outcomes: meaningful not! PMID- 9952137 TI - Simple, easy, safe, and inexpensive. But is it efficacious? PMID- 9952138 TI - Antiemetic prophylaxis does not improve outcomes after outpatient surgery when compared to symptomatic treatment. AB - BACKGROUND: Although prophylactic administration of antiemetics reduces the incidence of postoperative nausea, vomiting, or both (PONV), there is little evidence to suggest this improves patient outcomes. The authors hypothesized that early symptomatic treatment of PONV will result in outcomes, including time to discharge, unanticipated admission, patient satisfaction, and time to return to normal daily activities, that are similar to those achieved with routine prophylaxis. METHODS: Men and women (n = 575) scheduled for outpatient surgery during general anesthesia were randomized to receive either 4 mg intravenous ondansetron or placebo before operation and either 1 mg intravenous ondansetron or placebo if postoperative symptomatic treatment of PONV was necessary. Patients were stratified into subgroups by risk factors for PONV. RESULTS: No differences occurred in the time to discharge, rate of unanticipated admission, or time to return to normal activity between the prophylaxis and treatment groups. The reported level of satisfaction with control of PONV was 93% in the treatment arm and 97% in the prophylaxis arm, which fall within the limits defined a priori as clinically equivalent. Female patients with a history of motion sickness or PONV who were undergoing highly emetogenic procedures had a higher reported level of satisfaction with prophylaxis than with treatment (100% vs. 90%, P = 0.043); however, the level of satisfaction with the overall outpatient surgical experience was not different. CONCLUSION: Although PONV is unpleasant, the data indicate little difference in outcomes when routine prophylactic medications are administered versus simply treating PONV should symptoms occur. PMID- 9952139 TI - Airway obstruction and perioperative complications in smokers undergoing abdominal surgery. AB - BACKGROUND: The goal of this study was to determine whether airway obstruction determined by preoperative spirometry predicts perioperative complications in smokers undergoing abdominal surgery whose treatment is managed according to current clinical practice. METHODS: A pulmonary function database identified patients undergoing abdominal surgery who met the following criteria for airway obstruction (n = 135): a forced expiratory volume less than 40% of predicted normal value, a forced expiratory volume:forced vital capacity ratio less than the lower limit of predicted normal, a smoking history of more than 20 pack years, and an age older than 35 yr. A group of patients without airway obstruction (n = 135) was matched for gender, surgical site (upper vs. lower abdominal), smoking history, and age. Medical records were reviewed by an abstractor to identify perioperative complications that occurred within 30 days after surgery. RESULTS: The forced expiratory volume values were 0.9+/-0.21 (mean +/- SD) and 2.9+/-0.61 in patients with and without airway obstruction, respectively. When analyzed by conditional logistic regression using the 1:1 matched-pairs feature, including age, pack-year smoking history, site of incision, and current smoking status as covariates, in patients with airway obstruction bronchospasm was more likely to develop (odds ratio, 6.9 [95% confidence interval, 1.2 to 38.4]) but the patients were not more likely to need prolonged endotracheal intubation (odds ratio, 1.1 [95% confidence interval, 0.4 to 3.2]). They were also no more likely to need prolonged intensive care admission or readmission. The frequency of other complications was less than 5%. CONCLUSION: When other factors were considered, preoperative airway obstruction predicted the occurrence of bronchospasm, but not prolonged endotracheal intubation, in smokers undergoing abdominal surgery who are treated according to current clinical practices. PMID- 9952140 TI - Effect of oxygen treatment on heart rate after abdominal surgery. AB - BACKGROUND: Cardiac complications are common during the postoperative period and may be associated with hypoxemia and tachycardia. Preliminary studies in high risk patients after operation have shown a possible beneficial effect of oxygen therapy on arterial oxygen saturation and heart rate. METHODS: The authors studied the effect of oxygen therapy on arterial oxygen saturation and heart rate in 100 consecutive unselected patients randomly and double blindly allocated to receive air or oxygen therapy between the first and fourth day after major abdominal surgery. RESULTS: The median arterial oxygen saturation rate increased significantly from 96% to 99% (P < 0.0001) and the heart rate decreased significantly from 85 beats/min to 81 beats/min (P < 0.0001) during oxygen supplementation compared with air administered by a binasal catheter. The greatest decrease in heart rate occurred in patients with the lowest oxygen saturation or the highest heart rate values before oxygen supplementation. Overall, 73% of this unselected group of patients responded with decreased heart rate during supplemental oxygen therapy. No significant differences in changes in heart rate after oxygen supplementation were found between patients with or without an epidural catheter or between the postoperative day studied. CONCLUSION: Postoperative oxygen therapy increased arterial oxygen saturation and decreased heart rate after uncomplicated abdominal surgery in a consecutive unselected group of patients who received routine postoperative care. PMID- 9952141 TI - Assessment of changes in coagulation in parturients with preeclampsia using thromboelastography. AB - BACKGROUND: Preeclampsia is associated with a risk of abnormal hemostasis that occurs most commonly secondary to thrombocytopenia. Thromboelastography measures whole blood coagulation and has been used to manage coagulation defects in obstetric patients. The authors conducted this investigation in a large number of preeclamptic women to assess changes in coagulation using thromboelastography. METHODS: Thromboelastography and platelet counts were performed in 52 healthy pregnant women, 140 mild preeclamptic women, and 114 severe preeclamptic women in active labor using disposable plastic cups and pins and native whole blood. In preeclamptic patients with a platelet count <100,000/mm3, conventional coagulation tests were also performed. Epidural analgesia was provided in some women when they requested pain relief. RESULTS: Fifteen percent of all preeclamptic women (38 of 254) and 2% (1 of 52) of healthy pregnant women had a platelet count <100,000/mm3. The incidence of thrombocytopenia <100,000/mm3 was 3% (4 of 140) and 30% (34 of 114) in mild preeclamptic patients and severe preeclamptic patients, respectively. Severe preeclamptic patients with a platelet count <100,000/mm3 were significantly hypocoagulable when compared to the other study groups. Ten severe preeclamptic women with a platelet count <100,000/mm3 had a maximum amplitude <54 mm (the lower limit of maximum amplitude in healthy pregnant women enrolled in this investigation). None of the mild preeclamptic women had a maximum amplitude <54 mm. Five severe preeclamptic women with a platelet count <100,000/mm3 had an abnormal coagulation profile, whereas all four mild preeclamptic women with a platelet count <100,000/mm3 had a normal coagulation profile. CONCLUSION: This study shows that severe preeclamptic women with a platelet count <100,000/mm3 are hypocoagulable when compared to healthy pregnant women and other preeclamptic women. PMID- 9952142 TI - Endotracheal intubation, but not laryngeal mask airway insertion, produces reversible bronchoconstriction. AB - BACKGROUND: Tracheal intubation frequently results in an increase in respiratory system resistance that can be reversed by inhaled bronchodilators. The authors hypothesized that insertion of a laryngeal mask airway would be less likely to result in reversible bronchoconstriction than would insertion of an endotracheal tube. METHODS: Fifty-two (45 men, 7 women) patients were randomized to receive a 7.5-mm (women) or 8-mm (men) endotracheal tube or a No. 4 (women) or No. 5 (men) laryngeal mask airway. Anesthesia was induced with 2 microg/kg fentanyl and 5 mg/kg thiopental, and airway placement was facilitated with 1 mg/kg succinylcholine. When a seal to more than 20 cm water was verified, respiratory system resistance was measured immediately after airway placement. Inhalation anesthesia was begun with isoflurane to achieve an end-tidal concentration of 1% for 10 min. Respiratory system resistance was measured again during identical conditions. RESULTS: Among patients receiving laryngeal mask airways, the initial respiratory system resistance was significantly less than among patients with endotracheal tubes (9.2+/-3.3 cm water x 1(-1) x s(-1) [mean +/- SD] compared with 13.4+/-9.6 cm water x 1(-1) x s(-1); P < 0.05). After 10 min of isoflurane, the resistance decreased to 8.6+/-3.6 cm water x 1(-1) x s(-1) in the endotracheal tube group but remained unchanged at 9.1+/-3.3 cm water x 1(-1) x s( 1) in the laryngeal mask airway group. The decrease in respiratory system resistance in the endotracheal tube group of 4.7+/-7 cm water x 1(-1) x s(-1) was highly significant compared with the lack of change in the laryngeal mask airway group (P < 0.01). CONCLUSIONS: Resistance decreased rapidly only in patients with endotracheal tubes after they received isoflurane, a potent bronchodilator, suggesting that reversible bronchoconstriction was present in patients with endotracheal tubes but not in those with laryngeal mask airways. A laryngeal mask airway is a better choice of airway to minimize airway reaction. PMID- 9952143 TI - Pulmonary airway resistance with the endotracheal tube versus laryngeal mask airway in paralyzed anesthetized adult patients. AB - BACKGROUND: The hypothesis that airway resistance is less with the laryngeal mask airway than with the endotracheal tube was tested. METHODS: Thirty-six paralyzed, anesthetized adult patients with no respiratory disease (American Society of Anesthesiologists physical status 1-3; age, 18-80 yr) were randomly allocated (9 men, 9 women in each group) to receive either a size-4 laryngeal mask airway or an endotracheal tube (men, 9-mm ID; women, 8-mm ID). A pulmonary monitor with flow transducer and esophageal balloon was used to measure peak airway pressure and mean airway resistance (device resistance plus pulmonary airway resistance) at three different tidal volumes (5, 10, and 15 ml/kg). Device resistance was measured in vitro with the distal end of the endotracheal tube or laryngeal mask airway open to the atmosphere and using the same ventilator settings. Pulmonary airway resistance was derived by subtracting the mean device resistance from the mean airway resistance. RESULTS: Peak airway pressure, mean airway resistance, device resistance, and pulmonary airway resistance were greater for the endotracheal tube (all P < 0.0001). CONCLUSIONS: The laryngeal mask airway triggers less bronchoconstriction than does the endotracheal tube in paralyzed anesthetized adult patients. This may have implications for maintaining intraoperative pulmonary function and reducing the risk for atelectasis and pulmonary infection. PMID- 9952144 TI - The effect of fentanyl on sevoflurane requirements for somatic and sympathetic responses to surgical incision. AB - BACKGROUND: Fentanyl produces a reduction in the minimum alveolar concentration (MAC) of isoflurane and desflurane needed to blockade adrenergic response (BAR) to surgical incision in 50% of patients (MAC-BAR). MAC-BAR of sevoflurane and the reduction in MAC-BAR of sevoflurane by fentanyl have not been described previously. The purpose of this study was to determine the MAC and MAC-BAR reduction of sevoflurane by fentanyl with and without nitrous oxide (N2O). METHODS: Two hundred twenty-six patients were randomly assigned to one of two groups: a sevoflurane group and a sevoflurane/N2O group. Patients in each group were randomly assigned to one of five different fentanyl concentration subgroups. Patients were anesthetized with sevoflurane and fentanyl in the sevoflurane group and with sevoflurane, fentanyl, and N2O (66 vol%) in the sevoflurane/N2O group. Somatic and sympathetic responses to surgical incision were observed for MAC and MAC-BAR assessment at predetermined concentrations of sevoflurane. RESULTS: Fentanyl produced an initial steep reduction in the MAC and MAC-BAR of sevoflurane, with 3 ng/ml resulting in a 61% reduction in MAC and an 83% reduction in MAC-BAR. A ceiling effect was observed for MAC and MAC-BAR, with 6 ng/ml fentanyl providing only an additional 13% and 9% reduction in MAC and MAC BAR, respectively. In the presence of 66 vol% N2O, MAC and MAC-BAR of sevoflurane were reduced with increasing concentrations of fentanyL A ceiling effect was not observed for reduction in MAC and MAC-BAR in the presence of N2O. CONCLUSIONS: MAC and MAC-BAR decreased similarly with increasing concentrations of fentanyl in plasma, showing an initial steep reduction followed by a ceiling effect. In the presence of N2O, MAC and MAC-BAR decreased similarly but did not exhibit a ceiling effect. PMID- 9952145 TI - Effects of xenon on hemodynamic responses to skin incision in humans. AB - BACKGROUND: The authors evaluated the hemodynamic suppressive effects of xenon in combination with sevoflurane at skin incision in patients undergoing surgery. METHODS: Forty patients were assigned randomly to receive one of the following four anesthetics: 1.3 minimum alveolar concentration (MAC) sevoflurane, 0.7 MAC xenon with 0.6 MAC sevoflurane, 1 MAC xenon with 0.3 MAC sevoflurane, or 0.7 MAC nitrous oxide with 0.6 MAC sevoflurane (n = 10 each group). Systolic blood pressure and heart rate were measured before anesthesia, before incision, and approximately 1 min after incision. RESULTS: The changes in hemodynamic variables in response to incision were less with sevoflurane in combination with xenon and nitrous oxide than with sevoflurane alone. Changes in heart rate (in beats/min) were 19+/-11 (+/- SD) for sevoflurane alone, 11+/-6 for 0.7 MAC xenon sevoflurane, 4+/-4 for 1 MAC xenon-sevoflurane, and 8+/-7 for nitrous oxide sevoflurane. Changes in systolic blood pressure were 35+/-18 mmHg for sevoflurane alone, 18+/-8 mmHg for 0.7 MAC xenon-sevoflurane, 16+/-7 mmHg for 1 MAC xenon sevoflurane, and 14+/-10 mmHg for nitrous oxide-sevoflurane. CONCLUSIONS: Xenon and nitrous oxide in combination with sevoflurane can reduce hemodynamic responses to skin incision compared with sevoflurane alone. One probable explanation may be that xenon has analgesic properties similar to those of nitrous oxide, although the exact mechanism is yet to be determined. PMID- 9952146 TI - Perioperative pharmacodynamics of acetaminophen analgesia in children. AB - BACKGROUND: There are no adequate pharmacodynamic data relating concentrations of acetaminophen in serum to analgesia. METHODS: Children undergoing outpatient tonsillectomy were administered acetaminophen either orally, 0.5-1.0 h preoperatively (n = 20), or per rectum at induction of anesthesia (n = 100). No other analgesic agents were administered. Individual concentrations of acetaminophen in serum and pain scores (0-10) measured over a 4-h postoperative period were analyzed using a nonlinear mixed-effects model (NONMEM). RESULTS: Mean (% CV) estimates of population pharmacokinetic parameters with percent coefficient of variation, standardized to a 70-kg person, for a one-compartment model with first-order input, lag time, and first order-elimination were a volume of distribution of 60 (21) 1 and a clearance of 13.5 (46) 1/h. Rectally administered acetaminophen had an absorption half-life of 35 (63) min with a lag time of 40 min. The absorption half-life for the oral preparation was 4.5 (63) min without a detectable lag time. The relative bioavailability of the rectal compared with the oral formulation was 0.54. The equilibration half-time of an effect compartment was 1.6 (131) h. Pharmacodynamic population parameter estimates (percent coefficient of variation) for a fractional sigmoidal Emax model, in which the greatest possible pain relief equates to an Emax of 1, were Emax = 1, EC50 (the concentration producing 50% of Emax) = 3.4 (94) mg/l, and Hill coefficient = 0.54 (42). CONCLUSIONS: The pharmacodynamics of acetaminophen can be described using a sigmoidal Emax model with a low Hill coefficient. To achieve a mean posttonsillectomy pain score of 3.6 of 10, an effect compartment concentration of 10 mg/l is necessary. PMID- 9952147 TI - Dexmedetomidine failed to block the acute hyperdynamic response to electroconvulsive therapy. AB - BACKGROUND: Orally administered clonidine (0.2-0.3 mg) has been reported to decrease the acute hypertensive response to electroconvulsive therapy (ECT) without prolonging early recovery. This preliminary study was designed to evaluate the acute hemodynamic effects of the investigational alpha2-adrenergic agonist, dexmedetomidine, in patients undergoing a series of ECT treatments. METHODS: Six patients undergoing a series of three to six consecutive ECT treatments were studied according to a randomized, double-blind, placebo controlled protocol All patients received either saline or dexmedetomidine, 0.5 or 1.0 microg/kg intravenously, 10-30 min before induction of anesthesia for ECT using a standardized anesthesia protocol. In addition to assessing the cardiovascular variables, the duration of seizure activity, degree of sedation, and time to discharge from the Phase I recovery unit were assessed. RESULTS: Although dexmedetomidine produced dose-related increases in the level of sedation before the ECT procedure, it failed to decrease the peak blood pressure and heart rate responses after the ECT treatment. The 0.5 and 1.0 microg/kg doses of dexmedetomidine prolonged the times to orientation and to discharge from the Phase I unit. CONCLUSIONS: The results of this pilot study suggest that dexmedetomidine (0.5-1.0 microg/kg given intravenously) is not beneficial in controlling the acute hyperdynamic response after ECT. PMID- 9952148 TI - Molar potency is predictive of the speed of onset of neuromuscular block for agents of intermediate, short, and ultrashort duration. AB - BACKGROUND: The times to peak effect of rocuronium, vecuronium, cisatracurium, mivacurium, and succinylcholine were evaluated to confirm that the correlation between potency and onset time observed for long-acting relaxants also held for drugs of intermediate and short duration. METHODS: The authors recruited 99 patients classified as American Society of Anesthesiologists physical status score 1 or 2 for the study. After anesthesia was induced, tracheal intubation was accomplished without relaxants. Anesthesia was maintained with nitrous oxide and 3% or 4% end-tidal desflurane plus intravenous narcotic supplementation. The evoked electromyographic response to single stimuli administered at 0.10 Hz was recorded continuously. Drug doses were selected to produce approximately 95% twitch depression. If peak twitch depression did not fall in the range of 90% to 98%, the patient was excluded from the study. The time to 50% to 90% of peak effect was plotted as a function of the administered dose. RESULTS: There was no difference in the onset profiles of mivacurium and vecuronium, or in the time to 50% of peak effect between succinylcholine and rocuronium. For all other parameters, onset times ranked as follows: succinylcholine < rocuronium < vecuronium-mivacurium < cisatracurium (P < 0.05). When the log of the ED95 in micromoles per kilogram for all five drugs was plotted against the log of onset time to 50% peak effect, the R2 value for the best fit line was more than 0.98. CONCLUSIONS: The inverse correlation between the molar potency and speed of onset previously described for agents of long duration also applies to nondepolarizing agents of intermediate and short duration. The onset time of succinylcholine also appears to be compatible with this relation. PMID- 9952149 TI - Ondansetron is effective to treat spinal or epidural morphine-induced pruritus. AB - BACKGROUND: Spinally and epidurally administered morphine is frequently associated with pruritus. Isolated case reports indicate that ondansetron may be effective in this context. This study aims to investigate the effectiveness of ondansetron to treat this side effect. METHODS: In a prospective, randomized, double-blind, placebo-controlled study, 100 patients with pruritus (> 4 on a visual analog scale, on which 0 represents no pruritus and 10 represents worst pruritus imaginable) after spinal or epidural administration of morphine, received either 8 mg ondansetron intravenously (ondansetron group) in 100 ml NaCl 0.9% or vehicle (placebo group). A decrease of more than 4 points on the visual analog scale 60 min after treatment was considered a success. Changes in levels of pain and sedation, hemodynamic values, and other side effects were checked regularly. The presence or absence of pruritus was assessed for the last time 24 h later. RESULTS: The two groups were similar for demographic characteristics, the route of administration of morphine, and severity of pruritus at the beginning of the study. The ondansetron group showed a success rate of 70% versus 30% for the placebo group (P > 0.05). Among the successfully treated patients, three (9%) in the ondansetron group and six (40%) in the placebo group reported the recurrence of pruritus (P < 0.05). Among the successfully treated patients, none complained of residual pruritus 24 h later. No changes in pain or sedation levels were noted. Hemodynamic values remained stable, hemoglobin oxygen saturation did not decrease, and no other side effects were observed. CONCLUSION: The administration of 8 mg ondansetron intravenously is an effective treatment for spinally or epidurally administered morphine-induced pruritus. In this clinical condition the treatment is safe and well tolerated. PMID- 9952150 TI - Dose-response relationship of intrathecal morphine for postcesarean analgesia. AB - BACKGROUND: This series investigated the quality of analgesia and the incidence and severity of side effects of intrathecal morphine for post-cesarean analgesia administered over a dose range of 0.0-0.5 mg. METHODS: ONE hundred eight term parturients undergoing cesarean delivery at term and given spinal anesthesia were randomized to receive a single dose of intrathecal morphine (0.0, 0.025, 0.05, 0.075, 0.1, 0.2, 0.3, 0.4, or 0.5 mg). A patient-controlled analgesia (PCA) device provided free access to additional analgesics. PCA morphine use, incidence and severity of side effects, and need for treatment interventions were recorded for 24 h. Data were analyzed with analysis of variance and linear regression analysis for trends among groups. RESULTS: Patient-controlled analgesia use differed significantly between groups; PCA use was higher in the control group than in groups receiving 0.075, 0.1, 0.3, 0.4, or 0.5 mg. Twenty-four-hour PCA morphine use was 45.7 mg lower (95% CI, 4.8-86.6 mg lower) in the 0.075-mg group than the control group. There was no difference in PCA morphine use between the 0.075- and 0.5-mg groups (95% CI, 36.8 mg lower to 45.0 mg higher); despite a fivefold increase in intrathecal morphine dose, PCA morphine use remained constant. There was no difference between control and treatment groups or among treatment groups with respect to nausea and vomiting. Pruritus and the need for treatment interventions increased in direct proportion to the dose of intrathecal morphine (linear regression, P = 0.001 and P = 0.0002, respectively). CONCLUSIONS: These data indicate there is little justification for use of more than 0.1 mg for post-cesarean analgesia. For optimal analgesia, augmentation [corrected] of intrathecal morphine with systemic opioids may be necessary. PMID- 9952151 TI - Dilution of spinal lidocaine does not alter the incidence of transient neurologic symptoms. AB - BACKGROUND: Although it has been suggested that the dilution of 5% hyperbaric lidocaine before injection for spinal anesthesia may decrease the incidence of transient neurologic symptoms, previous studies have not noted a decreased incidence between 5% and 2% lidocaine. The aim of the current study was to determine whether the incidence of transient neurologic symptoms could be altered by further diluting spinal lidocaine from 2.0% to 0.5%. METHODS: One hundred nine patients with American Society of Anesthesiologists physical status 1 or 2 undergoing outpatient knee arthroscopy were randomized in a double-blind fashion to receive 50 mg hyperbaric spinal lidocaine as a 2.0%, 1.0%, or 0.5% concentration. On the third postoperative day, patients were contacted by a blinded investigator and questioned regarding the incidence of postoperative complications, including transient neurologic symptoms, defined as pain or dysthesia in one or both buttocks or legs occurring within 24 h of surgery. RESULTS: The incidence of transient neurologic symptoms did not differ among patients receiving 2.0% (incidence of 15.8%), 1.0% (incidence of 22.2%), and 0.5% (incidence of 17.1%) lidocaine (P = 0.756). CONCLUSIONS: For ambulatory patients undergoing arthroscopy, the incidence of transient neurologic symptoms is not reduced by decreasing spinal lidocaine concentrations from 2.0% to 1.0% or 0.5%. The incidences of transient neurologic symptoms with the 0.5%, 1.0%, and 2.0% solutions are similar to previously reported incidences for 5.0% lidocaine, suggesting that dilution of lidocaine from 5.0% to 0.5% does not change the incidence of these symptoms. PMID- 9952152 TI - Population pharmacokinetic modeling in very premature infants receiving midazolam during mechanical ventilation: midazolam neonatal pharmacokinetics. AB - BACKGROUND: Midazolam is used widely as a sedative to facilitate mechanical ventilation. This prospective study investigated the population pharmacokinetics of midazolam in very premature infants. METHODS: Midazolam (100 microg/kg) was administered as a rapid intravenous bolus dose every 4-6 h to 60 very premature neonates with a mean (range) gestational age of 27 weeks (24-31 weeks), a birth weight of 965 g (523-1,470 g), and an age of 4.5 days (2-15 days). A median (range) of four (one to four) blood samples, 0.2 ml each, were drawn at random times after the first dose or during continuous treatment, and concentrations of midazolam in serum were assayed by high-performance liquid chromatography. A population analysis was conducted using a two-compartment pharmacokinetic model using the NONMEM program. RESULTS: Average parameter values (interpatient percent coefficient of variation) for infants with birth weights 1,000 g or less were total systemic clearance (Cl(T)) = 0.783 ml/min (83%), intercompartmental clearance (Cl(Q)) = 6.53 ml/min (116%), volume of distribution of the central compartment (V1) = 473 ml (70%), and volume of distribution of the peripheral compartment (V2) = 513 ml (146%). For infants with birth weights more than 1,000 g they were as follows: Cl(T) = 1.24 ml/min (78%), Cl(Q) = 9.82 ml/min (98%), V1 = 823 ml (43%), and V2 = 1,040 ml (193%). The intrapatient variability (percent coefficient of variation) in the data was 4.5% at the mean concentration midazolam in serum of 121 ng/mL. CONCLUSIONS: Serum concentration-time data were used in modeling the population pharmacokinetics of midazolam in very premature, ventilated neonates. Clearance of midazolam was markedly decreased compared with previous data from term infants and older patients. Infants weighing less than 1,000 g at birth had significantly lower clearance than those weighing more than 1,000 g. PMID- 9952153 TI - Immunochemical evidence against the involvement of cysteine conjugate beta-lyase in compound A nephrotoxicity in rats. AB - BACKGROUND: Compound A, a degradation product of sevoflurane, causes renal corticomedullary necrosis in rats. Although the toxicity of this compound was originally hypothesized to result from the biotransformation of its cysteine conjugates into toxic thionoacyl halide metabolites by renal cysteine conjugate beta-lyase, recent evidence suggests that alternative mechanisms may be responsible for compound A nephrotoxicity. The aim of this study was to evaluate these issues by determining whether mercapturates and glutathione conjugates of compound A could produce renal corticomedullary necrosis in rats, similar to compound A, and whether renal covalent adducts of the thionacyl halide metabolite of compound A could be detected immunochemically. METHODS: Male Wistar rats were administered, intraperitoneally, N-acetylcysteine conjugates (mercapturates) of compound A (90 or 180 micromol/kg) or glutathione conjugates of compound A (180 micromol/kg) with or without intraperitoneal pretreatments with aminooxyacetic acid (500 micromol/kg) or acivicin (250 micromol/kg). Rats were killed after 24 h, and kidney tissues were analyzed for toxicity by histologic examination or for protein adducts by immunoblotting or immunohistochemical analysis, using antisera raised against the covalently bound thionoacyl halide metabolite of compound A. RESULTS: Mercapturates and glutathione conjugates of compound A both produced renal corticomedullary necrosis similar to that caused by compound A. Aminooxyacetic acid, an inhibitor of renal cysteine conjugate beta-lyase, did not inhibit the toxicity of the mercapturates, whereas acivicin, an inhibitor of gamma-glutamyltranspeptidase, potentiated the toxicity of both classes of conjugates. No immunochemical evidence for renal protein adducts of the thionacyl halide metabolite was found in rats 24 h after the administration of the mercapturates of compound A or in the kidneys of rats, obtained from a previous study, 5 and 24 h after the administration of compound A. CONCLUSION: The results of this study are consistent with the idea that a mechanism other than the renal cysteine conjugate beta-lyase pathway of metabolic activation is responsible for the nephrotoxicity of compound A and its glutathione and mercapturate conjugates in male Wistar rats. PMID- 9952154 TI - Nitrous oxide produces antinociceptive response via alpha2B and/or alpha2C adrenoceptor subtypes in mice. AB - BACKGROUND: Opiate receptors in the periaqueductal gray region and alpha2 adrenoceptors in the spinal cord of the rat mediate the antinociceptive properties of nitrous oxide (N2O). The availability of genetically altered mice facilitates the detection of the precise protein species involved in the transduction pathway. In this study, the authors establish the similarity between rats and mice in the antinociceptive action of N2O and investigate which alpha2 adrenoceptor subtypes mediate this response. METHODS: After obtaining institutional approval, antinociceptive dose-response and time-course to N2O was measured in wild-type and transgenic mice (D79N), with a nonfunctional alpha2A adrenoceptor using tail-flick latency. The antinociceptive effect of N2O was tested after pretreatment systemically with yohimbine (nonselective alpha2 antagonist), naloxone (opiate antagonist), L659,066 (peripheral alpha2 antagonist) and prazosin (alpha2B- and alpha2C-selective antagonist). The tail flick latency to dexmedetomidine (D-med), a nonselective alpha2 agonist, was tested in wild-type and transgenic mice. RESULTS: N2O produced antinociception in both D79N transgenic and wild-type litter mates, although the response was less pronounced in the transgenic mice. Antinociception from N2O decreased over time with continuing exposure, and the decrement was more pronounced in the transgenic mice. The antinociceptive response could be dose dependently antagonized by opiate receptor and selective alpha2B-/alpha2C-receptor antagonists but not by a central nervous system-impermeant alpha2 antagonist (L659,066). Whereas dexmedetomidine exhibited no antinociceptive response in the D79N mice, the robust antinociceptive response in the wild-type litter mates could not be blocked by a selective alpha2B-/alpha2C-receptor antagonist. CONCLUSION: These data confirm that the antinociceptive response to an exogenous alpha2-agonist is mediated by an alpha2A adrenoceptor and that there appears to be a role for the alpha2B- or alpha2C-adrenoceptor subtypes, or both, in the analgesic response to N2O. PMID- 9952155 TI - The pulmonary first-pass uptake of five nondepolarizing muscle relaxants in the pig. AB - BACKGROUND: It is not known whether the lungs influence the early pharmacokinetics of muscle relaxants and, if they do, whether differences in pulmonary uptake contribute to the differences in potency and/or onset time among muscle relaxants. Because the lungs are uniquely positioned, receive the entire cardiac output, have a large capillary surface area, and can temporarily store various basic drugs, the authors determined whether substantial pulmonary first pass uptake of muscle relaxants occurs. METHODS: In 14 pigs, rocuronium, vecuronium, Org 9487, Org 7617, or d-tubocurarine were administered simultaneously with indocyanin green within 1 s into the right ventricle, and then arterial blood was sampled every 1.2 s (in the first min). The tibialis muscle response was registered mechanomyographically. RESULTS: The maximum block was 93% (68-100% [median and range]). Onset times ranged from 83 s (78-86 s) for rocuronium to 182 s (172-192 s) for d-tubocurarine. Fraction-versus-time outflow curves showed that the peak of muscle relaxants and indocyanin green occurred almost simultaneously. Pulmonary first-pass retention was negligible. The retention of muscle relaxants at 95% passage of indocyanin green was -9% (-31 to 18%). The difference in the mean transit time between muscle relaxant and indocyanin green was 1.0 (0.8 to 1.4), 0.2 (-0.8 to 0.3), 0.3 (0.2 to 0.4), 0.5 (0.2 to 1.3), and -2.2 s for rocuronium, vecuronium, Org 9487, Org 7617, and d tubocurarine, respectively. CONCLUSIONS: There is no substantial pulmonary first pass uptake of rocuronium, vecuronium, Org 9487, Org 7617, or d-tubocurarine in pigs. Therefore, differences in pulmonary first-pass uptake do not contribute to the differences in potency and/or onset time among muscle relaxants. PMID- 9952156 TI - Effects of temperature and volatile anesthetics on GABA(A) receptors. AB - BACKGROUND: Potentiation of the activity of the gamma-aminobutyric acid type A (GABA(A)) receptor channel by volatile anesthetic agents is usually studied in vitro at room temperature. Systematic variation of temperature can be used to assess the relevance of this receptor to general anesthesia and to characterize the modulation of its behavior by volatile agents at normal body temperature. METHODS: Potentiation of the GABA(A) receptor by halothane, sevoflurane, isoflurane, and methoxyflurane was studied at six temperatures in the range 10-37 degrees C using the whole-cell patch-clamp technique and mouse fibroblast cells stably transfected with defined GABA(A) receptor subunits. RESULTS: Control GABA concentration-response plots showed small and physically reasonable changes in the GABA concentration required for a half-maximal effect, the Hill coefficient, and maximal response over the range 10-30 degrees C. Potentiations of GABA (1 microM) responses by aqueous minimum alveolar concentrations of the volatile anesthetic agents decreased with increasing temperature from 10-37 degrees C in an agent-specific manner (methoxyflurane > isoflurane > sevoflurane > halothane) but tended to equalize at normal body temperature (37 degrees C). These findings are in line with published results on the temperature dependence of anesthetic potencies in animals. CONCLUSIONS: These results are consistent with direct binding of volatile anesthetic agents to the GABA(A) receptor channel playing an important role in general anesthesia. The finding that the degree of anesthetic potentiation was agent-specific at low temperatures but not at 37 degrees C emphasizes the importance of doing in vitro experiments at normal body temperature. PMID- 9952157 TI - The antiallodynic effects of intrathecal cholinesterase inhibitors in a rat model of neuropathic pain. AB - BACKGROUND: This study determined the effect of intrathecally administered cholinesterase inhibitors, edrophonium and neostigmine, on nerve injury-induced, touch-evoked allodynia and identified the pharmacologic characteristics of this action. METHODS: Rats were prepared with tight ligation of the left L5 and L6 spinal nerves and with lumbar intrathecal catheters fitted for long-term monitoring. Edrophonium (3, 10, 30, or 100 microg) or neostigmine (0.3, 1, 3, or 10 microg) was administered intrathecally. Tactile allodynia and motor weakness were assessed. To evaluate the pharmacologic characteristics of the activity, a muscarinic receptor antagonist or a nicotinic receptor antagonist was administered intrathecally before edrophonium or neostigmine was injected. To compare the action of subtype antagonists, the M1 muscarinic receptor antagonist pirenzepine, the M2 antagonist methoctramine, the M3 antagonist 4-DAMP (diphenylacetoxy-N-methypiperidine), and the M4 antagonist tropicamide were administered intrathecally before cholinesterase inhibitors were injected. RESULTS: Intrathecal edrophonium or neostigmine produced a dose-dependent antagonism of the touch-evoked allodynia. Neostigmine resulted in a moderate effect on motor weakness at doses of 3 and 10 microg. Pretreatment with intrathecal atropine but not mecamylamine yielded a complete antagonism of the effects of the cholinesterase inhibitors. In addition, antiallodynia produced by edrophonium (100 microg) was reversed by pretreatment with methoctramine, 4-DAMP, tropicamide, and pirenzepine. In the neostigmine (10 microg) group, only the M1 antagonist pirenzepine had a moderate effect on reversal of increased allodynic threshold. CONCLUSIONS: These experiments suggest that intrathecal edrophonium or neostigmine produces an antagonism on touch-evoked allodynia at the spinal level in a rat model of neuropathic pain and that the antiallodynic action of cholinesterase inhibitors is probably mediated by a spinal muscarinic system, especially at the M1 receptor subtype. PMID- 9952158 TI - Spinal antinociceptive action of Na+-K+ pump inhibitor ouabain and its interaction with morphine and lidocaine in rats. AB - BACKGROUND: The Na+,K+-adenosine triphosphatase is a ubiquitous enzyme system that maintains the ion gradient across the plasma membrane of a variety of cell types, including cells in the central nervous system. We investigated the antinociceptive effect of intrathecally administered ouabain and examined its potential interaction with spinal morphine and lidocaine. METHODS: Using rats chronically implanted with lumbar intrathecal catheters, the ability of intrathecally administered ouabain, morphine, and lidocaine and of mixtures of ouabain-morphine and ouabain-lidocaine to alter tail-flick latency was examined. To characterize any interactions, isobolographic analysis was performed. The effects of pretreatment with intrathecally administered atropine or naloxone also were tested. RESULTS: Intrathecally administered ouabain (0.1-5.0 microg), morphine (0.2-10.0 microg), and lidocaine (25-300 microg) given alone produced significant dose- and time-dependent antinociception, but systemic administration of ouabain did not produce such an effect. The median effective dose (ED50) values for intrathecally administered ouabain, morphine, and lidocaine were 2.3, 5.0, and 227.0 microg, respectively. Isobolographic analysis exhibited a synergistic interaction after the coadministration of ouabain and morphine. With ouabain and lidocaine, there was no such evidence of synergism. Intrathecally administered atropine, but not naloxone, completely blocked the antinociceptive effect of ouabain and attenuated its interaction with spinally administered morphine. CONCLUSIONS: Intrathecally administered ouabain produces antinociception, at least in part, via an enhancement of cholinergic transmission in the spinal nociceptive processing system. The results of the interaction of ouabain with morphine and lidocaine suggest that modulation of Na+-,K+ electrochemical gradients and thus subsequent release of neurotransmitters in the spinal cord are likely to play important roles in the spinal antinociceptive effect of intrathecally administered ouabain. PMID- 9952159 TI - Intrathecal clonidine alleviates allodynia in neuropathic rats: interaction with spinal muscarinic and nicotinic receptors. AB - BACKGROUND: Intrathecally administered clonidine increases release of spinal acetylcholine, which may be related to its analgesic action in neuropathic pain. The current study determined the role of spinal muscarinic and nicotinic receptors in the antiallodynic effect of intrathecally administered clonidine in spinal nerve-ligated rats. METHODS: Allodynia was produced in rats by ligation of the left L5-L6 spinal nerves. Mechanical allodynia was determined by application of von Frey filaments to the left hindpaw. The effect of intrathecal injection of saline, two muscarinic receptor antagonists (atropine and scopolamine), and two nicotinic receptor antagonists (mecamylamine and hexamethonium) on the antiallodynic action produced by intrathecal administration of 20 microg clonidine was assessed in six groups of animals. Each group consisted of six to eight rats. RESULTS: Intrathecal injection of saline or muscarinic or nicotinic receptor antagonists did not alter the withdrawal thresholds. The antiallodynic effect produced by intrathecally administered clonidine was attenuated in a dose dependent manner by intrathecal treatment with muscarinic and nicotinic antagonists. Although nicotinic receptor antagonists only partially attenuated the effect of clonidine, blockade of spinal muscarinic receptors almost abolished the antiallodynic effect of clonidine. CONCLUSIONS: These results demonstrate that the analgesic effect of intrathecally administered clonidine on neuropathic pain is mediated by spinal muscarinic and nicotinic receptors. Therefore, this study provides functional evidence that spinally released acetylcholine plays a role in the antiallodynic effect of intrathecally administered clonidine in neuropathic pain. PMID- 9952160 TI - Dexamethasone changes brain monoamine metabolism and aggravates ischemic neuronal damage in rats. AB - BACKGROUND: Glucocorticoids have been reported to aggravate ischemic brain damage. Because changes in the activities of various neuronal systems are closely related to the outcome of ischemic damage, the authors evaluated the effects of dexamethasone on the monoaminergic systems and ischemic neuronal damage. METHODS: The right middle cerebral artery was occluded for 2 h, and the tissue concentrations of monoamines and their metabolites were determined in the cerebral cortex and the striatum of rats. The turnover of 5-hydroxytryptamine was compared in animals injected with saline and those injected with dexamethasone twice (2 mg/kg in each injection) by evaluating the probenecid-induced accumulation of 5-hydroxyindoleacetic acid. The turnovers of norepinephrine and dopamine were estimated from the alpha-methyl-p-tyrosine-induced depletion of norepinephrine and dopamine, respectively. The effect of dexamethasone on the infarct volume was evaluated by triphenyltetrazolium chloride stain in rats subjected to 2 h of occlusion. RESULTS: Dexamethasone did not affect the cortical 5-hydroxytryptamine or 5-hydroxyindoleacetic acid contents. However, it suppressed the turnover of the cortical 5-hydroxytryptamine on both sides. Dexamethasone reduced the turnover of the striatal 5-hydroxytryptamine and facilitated the dopamine turnover. In rats subjected to 2 h of occlusion and 2 h of reperfusion, the infarct volume was 10.5 times greater in the group that received dexamethasone than in the animals that received saline. CONCLUSIONS: Dexamethasone suppresses the inhibitory serotonergic system and facilitates the excitatory dopaminergic system in the rat telencephalon. This may be a mechanism by which dexamethasone aggravates ischemic neuronal injury. PMID- 9952161 TI - Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 sodium channel blockers. AB - BACKGROUND: Capsaicin, the pungent ingredient in chili peppers, is a vanilloid with noxious and analgesic effects that inhibits tetrodotoxin-resistant sodium currents. Because tetrodotoxin-resistant currents are found primarily in small diameter nociceptor afferents of the peripheral nerves, their inhibition may lead to selective analgesia. Therefore, the authors evaluated the interactions between tetrodotoxin, a site 1 sodium channel blocker, and capsaicin on nerve blockade in vivo. METHODS: Percutaneous sciatic nerve injections with 0 to 9.9 mM capsaicin, 0 to 120 microM tetrodotoxin, or both were administered to male Sprague-Dawley rats. Thermal nociceptive and motor blockade were measured. Data were expressed as medians with 25th and 75th percentiles. RESULTS: Capsaicin produced a transient increase in thermal latency with no effect on motor strength. Tetrodotoxin reduced motor strength for a longer duration than nociception. The interaction between tetrodotoxin and capsaicin was synergistic, as evidenced by (1) supraadditive prolongation of both nociceptive and motor block, with the effect of capsaicin reversed by the vanilloid antagonist capsazepine, and (2) synergism in the frequency that rats achieved maximal block shown by isobolographic analysis. The combination of tetrodotoxin and capsaicin showed less motor predominance than tetrodotoxin did alone. Similar interactions were found between tetrodotoxin and resiniferatoxin (another vanilloid), and between capsaicin and saxitoxin (another site 1 sodium channel blocker), but much less so between bupivacaine and capsaicin. CONCLUSIONS: Site 1 sodium channel blockers and vanilloids have synergistic effects on nerve blockade in vivo. These interactions may be useful in developing prolonged local anesthetics and elucidating mechanisms of functionally selective nerve blockade. PMID- 9952162 TI - The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat electroencephalographic model. AB - BACKGROUND: The purpose of this study was to investigate the in vivo pharmacodynamics and the pharmacodynamic interactions of remifentanil and its major metabolite, GR90291, in a rat electroencephalographic model. METHODS: Remifentanil and GR90291 were administered according to a stepwise infusion scheme. The time course of the electroencephalographic effect (0.5-4.5 Hz) was determined in conjunction with concentrations of the parent drug and the metabolite in blood. RESULTS: Administration of remifentanil resulted in concentrations of remifentanil and GR90291 in the ranges 0-120 ng/ml and 0-850 ng/ml, respectively. When the metabolite was administered, concentrations of the metabolite in the range 0-220 microg/ml and no measurable concentrations of remifentanil were observed. The mean +/- SE values of the pharmacokinetic parameters clearance and volume of distribution at steady state were 920+/-110 ml x min(-1) x kg(-1) and 1.00+/-0.93 l/kg for remifentanil and 15+/-2 ml x min(-1) x kg(-1) and 0.56+/-0.08 l/kg for GR90291. The relative free concentrations in the brain, as determined on the basis of the cerebrospinal fluid/total blood concentration ratio at steady state, were 25+/-5% and 0.30+/-0.11% for remifentanil and GR90291, respectively. Concentration-electroencephalographic effect relations were characterized on the basis of the sigmoidal Emax pharmacodynamic model. The mean +/- SE values for the maximal effect (Emax), the concentration at which 50% of the maximal effect is obtained (EC50), and Hill factor for remifentanil were 109+/-12 microV, 9.4+/-0.9 ng/ml, and 2.2+/-0.3, respectively (n = 8). For GR90291, the mean +/- SE values for EC50 and the Hill factor were 103,000+/-9,000 microg/ml and 2.5+/-0.4, respectively (n = 6). CONCLUSIONS: Analysis of the data on the basis of a previously postulated, mechanism-based pharmacokinetic-pharmacodynamic model for synthetic opioids revealed that the low in vivo potency of GR90291 can be explained by a low affinity to the mu-opioid receptor in combination with a poor brain penetration. PMID- 9952163 TI - GAS-1: a mitochondrial protein controls sensitivity to volatile anesthetics in the nematode Caenorhabditis elegans. AB - BACKGROUND: Mutations in several genes of Caenorhabditis elegans confer altered sensitivities to volatile anesthetics. A mutation in one gene, gas-1(fc21), causes animals to be immobilized at lower concentrations of all volatile anesthetics than in the wild-type, and it does not depend on mutations in other genes to control anesthetic sensitivity. gas-1 confers different sensitivities to stereoisomers of isoflurane, and thus may be a direct target for volatile anesthetics. The authors have cloned and characterized the gas-1 gene and the mutant allele fc21. METHODS: Genetic techniques for nematodes were as previously described. Polymerase chain reaction, sequencing, and other molecular biology techniques were performed by standard methods. Mutant rescue was done by injecting DNA fragments into the gonad of mutant animals and scoring the offspring for loss of the mutant phenotype. RESULTS: The gas-1 gene was cloned and identified. The protein GAS-1 is a homologue of the 49-kDa (IP) subunit of the mitochondrial NADH:ubiquinone-oxidoreductase (complex I of the respiratory chain). gas-1(fc21) is a missense mutation replacing a strictly conserved arginine with lysine. CONCLUSIONS: The function of the 49-kDa (IP) subunit of complex I is unknown. The finding that mutations in complex I increase sensitivity of C elegans to volatile anesthetics may implicate this physiologic process in the determination of anesthetic sensitivity. The hypersensitivity of animals with a mutation in the gas-1 gene may be caused by a direct anesthetic effect on a mitochondrial protein or secondary effects at other sites caused by mitochondrial dysfunction. PMID- 9952164 TI - Effects of xenon on the performance of various respiratory flowmeters. AB - BACKGROUND: The anesthetic gas xenon has distinctly different physical properties compared with air, nitrous oxide, or oxygen. This led us to predict that xenon would affect the performance of commercially available flowmeters. METHODS: Flow was generated by an anesthesia ventilator connected to a lung simulator via a semiclosed breathing circuit. With the system filled with air or with various concentrations of xenon or nitrous oxide in a balance of oxygen, the tidal volume was measured with two rotating vanes, a Pitot tube, a variable-orifice flowmeter, and two constant-temperature hot-wire flowmeters. RESULTS: Although xenon minimally affected both rotating vane flowmeters, it caused the Pitot tube and the variable-orifice flowmeters to overread in proportion to the square root of the density of the gas mixture used (xenon is 4.6 times more dense than air). In contrast, the hot-wire anemometers underread with xenon; for example, their readings in the presence of 45% and 70% xenon were less than 10% of those displayed when air was used. Nitrous oxide minimally affected all the flowmeters except the variable-orifice device. The Pitot flowmeter was also affected, but only when its gas analyzer port was open to the ambient air so that it no longer corrected its readings for changes in gas composition. In these cases, nitrous oxide produced overreadings in the same manner as did xenon. CONCLUSION: Among the four types of flowmeters studied, only the rotating-vane type is sufficiently accurate for use during anesthesia with xenon. PMID- 9952165 TI - Systemic air embolism after lung trauma. AB - Systemic air or gas embolism has been increasingly recognized as a complication of serious chest trauma and often presents with catastrophic circulatory and cerebral events. The classic findings are hemoptysis, sudden cardiac or cerebral dysfunction after initiation of PPV, air in retinal vessels, and air in arterial aspirations. The clinician must be wary of more subtle presentations. Several diagnostic tools (TEE, Doppler, CT) can detect intracardiac and cerebral air, but they may not be necessary to confirm the diagnosis of SAE. Cessation of SAE is essential for successful resuscitation. In those with unilateral lung injury, this can theoretically be achieved by isolating and ventilating the noninjured lung. Sole reliance on immediate thoracotomy for hilar clamping to stem the flow of gas emboli is a concept that needs to be challenged. Whether airway and ventilation interventions will eliminate, delay, or decrease the need for thoracotomy and improve the prognosis of SAE remains to be seen. There is little reported in the literature regarding such interventions. Airway management of a patient at risk for SAE should include a technique that can selectively ventilate each lung. Patients with bilateral sources of SAE may benefit from the avoidance of high airway pressures. Regional anesthesia should be considered when appropriate. HBOT is useful in managing cerebral air embolism and should be incorporated as soon as possible. Clinicians involved in trauma care must be familiar with SAE. By adopting a problem-based solution through innovative airway and ventilation management, anesthesiologists may significantly alter and improve the morbidity and mortality rate of SAE resulting from chest trauma. PMID- 9952166 TI - A review of the use of fentanyl analgesia in the management of acute pain in adults. PMID- 9952167 TI - Practice guidelines for obstetrical anesthesia: a report by the American Society of Anesthesiologists Task Force on Obstetrical Anesthesia. PMID- 9952169 TI - Intraoperative burns secondary to warmed i.v. bags: a warning. PMID- 9952168 TI - Severe carbon monoxide poisoning during desflurane anesthesia. PMID- 9952170 TI - Application of cell-salvage during cesarean section. PMID- 9952171 TI - Epidural anesthesia in a parturient with a lumboperitoneal shunt. PMID- 9952172 TI - Complete atrioventricular block and cardiac arrest following intravenous famotidine administration. PMID- 9952173 TI - The coexistence of portopulmonary hypertension and hepatopulmonary syndrome. PMID- 9952174 TI - Brain death during anesthesia due to undiagnosed meningeal carcinomatosis of gastric adenocarcinoma. PMID- 9952175 TI - Plus ca change. PMID- 9952176 TI - Missing documentation. PMID- 9952177 TI - Cost-efficient carbon dioxide monitoring via nasal cannula. PMID- 9952178 TI - Jetting lidocaine through the atomizer. PMID- 9952179 TI - Use of a modified lightwand for nasal intubation. PMID- 9952180 TI - Pacer-induced artifact in the bispectral index during cardiac surgery. PMID- 9952181 TI - Endotracheal tube damage in the presence of bite block. PMID- 9952182 TI - Postoperative myocardial infarction (PMI) after noncardiac surgery. PMID- 9952183 TI - A piece of my mind. A vision of health care for the next millennium. PMID- 9952184 TI - George D. Lundberg ousted as JAMA editor. PMID- 9952185 TI - Renewed efforts to improve the quality of health care. PMID- 9952186 TI - Report offers vision for microbicide development. PMID- 9952187 TI - New advocates of adequate treatment say have no fear of pain or of prosecution. PMID- 9952188 TI - From the Food and Drug Administration. PMID- 9952189 TI - From the Centers for Disease Control and Prevention. Progress toward eliminating Haemophilus influenzae type b disease among infants and children--United States, 1987-1997. PMID- 9952190 TI - From the Centers for Disease Control and Prevention. False-positive laboratory tests for Cryptosporidium involving an enzyme-linked immunosorbent assay--United States, November 1997-March 1998. PMID- 9952191 TI - Coronary events with lipid-lowering therapy: the AFCAPS/TexCAPS trial. Air Force/Texas Coronary Atherosclerosis Prevention Study. PMID- 9952192 TI - Coronary events with lipid-lowering therapy: the AFCAPS/TexCAPS trial. Air Force/Texas Coronary Atherosclerosis Prevention Study. PMID- 9952193 TI - Coronary events with lipid-lowering therapy: the AFCAPS/TexCAPS trial. Air Force/Texas Coronary Atherosclerosis Prevention Study. PMID- 9952194 TI - Coronary events with lipid-lowering therapy: the AFCAPS/TexCAPS trial. Air Force/Texas Coronary Atherosclerosis Prevention Study. PMID- 9952195 TI - Coronary events with lipid-lowering therapy: the AFCAPS/TexCAPS trial. Air Force/Texas Coronary Atherosclerosis Prevention Study. PMID- 9952196 TI - Coronary events with lipid-lowering therapy: the AFCAPS/TexCAPS trial. Air Force/Texas Coronary Atherosclerosis Prevention Study. PMID- 9952197 TI - Coronary events with lipid-lowering therapy: the AFCAPS/TexCAPS trial. Air Force/Texas Coronary Atherosclerosis Prevention Study. PMID- 9952198 TI - Coronary events with lipid-lowering therapy: the AFCAPS/TexCAPS trial. Air Force/Texas Coronary Atherosclerosis Prevention Study. PMID- 9952199 TI - Educating physicians to prevent sex-related contact with patients. PMID- 9952200 TI - Hemodynamic factors and symptomatic carotid artery occlusion. PMID- 9952201 TI - Sildenafil for treatment of erectile dysfunction in men with diabetes: a randomized controlled trial. Sildenafil Diabetes Study Group. AB - CONTEXT: Erectile dysfunction is common in men with diabetes. OBJECTIVE: To assess the efficacy and safety of oral sildenafil citrate in the treatment of erectile dysfunction in men with diabetes. DESIGN: A multicenter, randomized, double-blind, placebo-controlled, flexible dose-escalation study conducted May through November 1996. SETTING: Patients' homes and 19 clinical practice centers in the United States. PATIENTS: A total of 268 men (mean age, 57 years) with erectile dysfunction (mean duration, 5.6 years) and diabetes (mean duration, 12 years). INTERVENTIONS: Patients were randomized to receive sildenafil (n = 136) or placebo (n = 132) as needed, but not more than once daily, for 12 weeks. Patients took the study drug or placebo 1 hour before anticipated sexual activity. The starting dose of sildenafil citrate was 50 mg, with the option to adjust the dose to 100 mg or 25 mg based on efficacy and tolerability, to be taken as needed. MAIN OUTCOME MEASURES: Self-reported ability to achieve and maintain an erection for sexual intercourse according to the International Index of Erectile Function and adverse events. RESULTS: Two hundred fifty-two patients (94%) completed the study (131/136 in the sildenafil group, 121/132 in the placebo group). By intention-to-treat analysis, at 12 weeks, 74 (56%) of 131 patients in the sildenafil group reported improved erections compared with 13 (10%) of 127 patients in the placebo group (P<.001). The proportion of men with at least 1 successful attempt at sexual intercourse was 61 % (71/ 117) for the sildenafil group vs 22% (25/114) for the placebo group (P<.001). Adverse events related to treatment were reported for 22 (16%) of 136 patients taking sildenafil and 1 (1%) of 132 patients receiving placebo. The most common adverse events were headache (11% sildenafil, 2% placebo), dyspepsia (9% sildenafil, 0% placebo), and respiratory tract disorder (6% sildenafil, 2% placebo), predominantly sinus congestion or drainage. The incidence of cardiovascular adverse events was comparable for both groups (3% sildenafil, 5% placebo). CONCLUSION: Oral sildenafil is an effective and well-tolerated treatment for erectile dysfunction in men with diabetes. PMID- 9952202 TI - Antibiotics and risk of subsequent first-time acute myocardial infarction. AB - CONTEXT: Increasing evidence supports the hypothesis of a causal association between certain bacterial infections and increased risk of developing acute myocardial infarction. If such a causal association exists, subjects who used antibiotics active against the bacteria, regardless of indication, might be at lower risk of developing acute myocardial infarction than nonusers. OBJECTIVE: To determine whether previous use of antibiotics decreases the risk of developing a first-time acute myocardial infarction. DESIGN: Population-based case-control analysis. SETTING: The United Kingdom-based General Practice Research Database comprising 350 general practices. PATIENTS: A total of 3315 case patients aged 75 years or younger with a diagnosis of first-time acute myocardial infarction between 1992 and 1997 and 13139 controls without myocardial infarction matched to cases for age, sex, general practice attended, and calendar time. MAIN OUTCOME MEASURES: Use of antibiotics among those who did or did not have a first-time acute myocardial infarction. RESULTS: Cases were significantly less likely to have used tetracycline antibiotics (adjusted odds ratio [OR], 0.70; 95% confidence interval [CI], 0.55-0.90) or quinolones (adjusted OR, 0.45; 95% CI, 0.21-0.95). No effect was found for previous use of macrolides (primarily erythromycin), sulfonamides, penicillins, or cephalosporins. CONCLUSIONS: The findings from this large case-control analysis provide further, albeit indirect, evidence for an association between bacterial infections with organisms susceptible to tetracycline or quinolone antibiotics and the risk of acute myocardial infarction. These results of preliminary nature should stimulate more research to further explore the role of infections in the etiology of acute myocardial infarction. PMID- 9952203 TI - Association of managed care market share and health expenditures for fee-for service Medicare patients. AB - CONTEXT: Managed care has the potential to transform fundamentally the structure and functioning of the entire health care system, including the care provided to patients who are not enrolled in managed care plans. OBJECTIVE: To determine whether increasing health maintenance organization (HMO) market share is associated with decreased expenditures for the care of patients covered by Medicare's traditional fee-for-service plan, a group cared for well outside the boundaries of managed care. DESIGN AND SETTING: Data from the Health Care Financing Administration were used to compare expenditures for the care of Medicare fee-for-service beneficiaries for 802 market areas, representing the entire United States, for 1990 to 1994. These data were matched with data on system-wide (Medicare and non-Medicare) HMO market share in these areas. PATIENTS: All fee-for-service Medicare beneficiaries (1990-1994) except for those with end-stage renal disease. MAIN OUTCOME MEASURE: Average fee-for-service expenditure per fee-for-service Medicare beneficiary by market area. RESULTS: In a regression model, increases in system-wide HMO market share were associated with declines in both Part A and Part B fee-for-service expenditures per Medicare beneficiary (P<.001). Increases from 10% market share to 20% market share were associated with 2.0% decreases in Part A fee-for-service expenditures and 1.5% decreases in Part B fee-for-service expenditures. CONCLUSIONS: Managed care can have widespread effects on the health care system. Health care for individuals who are not covered by managed care organizations can be influenced by the presence of managed care. Lower expenditures in areas with high HMO market shares may indicate that traditional Medicare beneficiaries in areas with high market shares received fewer or less intensive services than traditional Medicare beneficiaries in other areas. PMID- 9952204 TI - Current and remote blood pressure and cognitive decline. AB - CONTEXT: Previous studies raise the possibility that blood pressure (BP) in middle age predicts later cognitive decline. OBJECTIVE: To examine prospectively the relationship of BP with level of and change in cognitive function in the elderly. DESIGN: Longitudinal, population-based study comprising subjects enrolled in the East Boston component of the Established Populations for the Epidemiologic Study of the Elderly (EPESE) (1982-1983) and the Hypertension Detection and Follow-Up Program (HDFP) (1973-1974). SETTING: East Boston, Mass. PARTICIPANTS: Of the 3657 participants in the EPESE with baseline BP measurements, 2068 also participated in the HDFP. Subjects were aged 65 to 102 years at baseline in the EPESE and had mental status and memory assessed at baseline and 3 and 6 years. MAIN OUTCOME MEASURES: Numbers of errors on the Short Portable Mental Status Questionnaire and the East Boston Memory Test and rates of change in these numbers of errors. Subjects had BP measured both at baseline in the EPESE and 9 years before, as part of the HDFP. RESULTS: In analyses adjusted for age, sex, and education, there was no strong linear association between BP and cognition. The associations found were fairly small in magnitude, and varied according to which test was used to measure cognition. There was little evidence for an effect of BP on change in cognitive function with either test, or for an effect on level of function on the memory test. In analyses of level of mental status questionnaire performance, however, elevated systolic BP (> or =160 mm Hg) 9 years before baseline was associated with a 14% (95% confidence interval [CI], 4%-25%) increase in error rate, relative to the referent (130-139 mm Hg). Baseline systolic BP had a U-shaped association with the number of errors; error rates were 9% higher compared with the referent group among those with systolic BP lower than 130 mm Hg (95% CI, 1%-17%) and 7% greater (95% CI, 0%-15%) among those with elevated systolic BP. Diastolic BP 9 years before baseline also had a U-shaped association with errors on the mental status questionnaire. CONCLUSION: The findings do not suggest a linear association of BP with cognitive decline, but they are consistent with a more complex relationship between BP and cognition than previously appreciated. PMID- 9952205 TI - Avoiding the unintended consequences of growth in medical care: how might more be worse? AB - The United States has experienced dramatic growth in both the technical capabilities and share of resources devoted to medical care. While the benefits of more medical care are widely recognized, the possibility that harm may result from growth has received little attention. Because harm from more medical care is unexpected, findings of harm are discounted or ignored. We suggest that such findings may indicate a more general problem and deserve serious consideration. First, we delineate 2 levels of decision making where more medical care may be introduced: (1) decisions about whether or not to use a discrete diagnostic or therapeutic intervention and (2) decisions about whether to add system capacity, eg, the decision to purchase another scanner or employ another physician. Second, we explore how more medical care at either level may lead to harm. More diagnosis creates the potential for labeling and detection of pseudodisease--disease that would never become apparent to patients during their lifetime without testing. More treatment may lead to tampering, interventions to correct random rather than systematic variation, and lower treatment thresholds, where the risks outweigh the potential benefits. Because there are more diagnoses to treat and more treatments to provide, physicians may be more likely to make mistakes and to be distracted from the issues of greatest concern to their patients. Finally, we turn to the fundamental challenge--reducing the risk of harm from more medical care. We identify 4 ways in which inadequate information and improper reasoning may allow harmful practices to be adopted-a constrained model of disease, excessive extrapolation, a missing level of analysis, and the assumption that more is better. PMID- 9952206 TI - Infectious mononucleosis in middle age. PMID- 9952207 TI - JAMA and editorial independence. PMID- 9952208 TI - Antibiotics for prevention of myocardial infarction? Not yet! PMID- 9952209 TI - The economist's model of physician behavior. PMID- 9952210 TI - Treatment of erectile dysfunction in men with diabetes. PMID- 9952211 TI - Serpents, staffs, and the emblems of medicine. PMID- 9952212 TI - Aesculapius: a modern tale. PMID- 9952213 TI - The white coat: why not follow suit? PMID- 9952214 TI - Rejuvenating the symbols of medicine. PMID- 9952215 TI - JAMA patient page: blood pressure. PMID- 9952217 TI - Bile acid malabsorption as a cause of chronic diarrhea: diagnostic value of 7alpha-hydroxy-4-cholesten-3-one in serum. AB - To evaluate the usefulness of 7a-hydroxy-4-cholesten-3-one (HCO) serum concentrations as a diagnostic marker of bile acid malabsorption, we determined the reference range of HCO in 106 normal subjects (age 40.2+/-16.8 years; 55 women, 51 men) and conducted a utility study in 23 patients with chronic diarrhea of unknown origin (age 49.4+/-15.3 years, 13 women, 10 men). The diagnosis of bile acid malabsorption was made on the basis of a decreased retention of [75Se]homocholyltaurine after oral application (75SeHCAT test). HCO (reference range: 6-48 ng/ml) and the 75SeHCAT test yielded the same results in 19/23 (83%) patients. Bile acid malabsorption was identified by an increase of HCO in serum with a sensitivity of 90% and a specificity of 79%. Analysis of HCO in serum may serve as a novel, simple, and sensitive method for the detection of bile acid malabsorption in patients with chronic diarrhea of unknown origin. PMID- 9952216 TI - Relationship of extraintestinal involvements in inflammatory bowel disease: new insights into autoimmune pathogenesis. AB - Extraintestinal manifestations in patients with inflammatory bowel disease (IBD) are quite common (about 25%) and careful clinical observation and statistical analysis during the last five decades have demonstrated that in colitis associated extraintestinal complications, the organs most commonly involved are the biliary tract, joints, skin, and eyes. However, almost all organs can be involved in IBD. Some of the extraintestinal manifestations may precede IBD, although the majority accompany the underlying disease and are influenced by its activity. Prompt recognition of extracolonic organ involvement in IBD is important because of the relative refractoriness of the disease and a possible increase in morbidity and mortality. The identified pathogenetic autoimmune mechanisms include genetic susceptibility, cytokine imbalances, antigenic display of autoantigen, aberrant self-recognition, and immunopathogenetic autoantibodies against organ-specific cellular antigen(s) shared by colon and extracolonic organs. Microbes may play an important role, probably by molecular mimicry. PMID- 9952218 TI - Central modulation of rectal distension-induced blood pressure changes by alosetron, a 5-HT3 receptor antagonist. AB - Irritable bowel syndrome (IBS) represents one of the most common gastrointestinal related diagnoses. Although the precise etiologic basis of IBS is not known, a common presenting symptom is abdominal pain or discomfort that is thought to develop, at least in part, from a heightened awareness of visceral nociceptive input. Agents capable of reducing this heightened visceral nociception would, therefore, have utility in the treatment of IBS. In this study we evaluated the effects of intravenous and intracerebroventricular administration of a 5-HT3 receptor antagonist, alosetron, on blood pressure changes associated with rectal distension in anesthetized and awake dogs. This vasoactive reflex serves as a model for visceral nociception. For intracerebroventricular studies, the cerebroventricular guides were placed over the lateral ventricle. In anesthetized studies, blood pressure was measured by femoral artery cannulation. In awake studies, blood pressure was monitored by noninvasive measurement. A rectal balloon was placed in the rectum of each dog and maintained throughout the experiments. Each dose of alosetron was given to the dogs as an intravenous or intracerebroventricular bolus, and every 30 min the rectal balloon was inflated and blood pressure responses observed. In both anesthetized and awake dogs alosetron produced a significant inhibition of the vasoactive reflex. In particular, alosetron showed high potency when administered intracerebroventricularly. Alosetron, administered either centrally or peripherally, appears to modulate the visceral nociceptive effect of rectal distension in dogs. PMID- 9952219 TI - Identification and characterization of a novel rat triosephosphate isomerase gene in remnant ileum after massive small bowel resection. AB - This paper describes the identification and characterization of a novel cDNA encoding a putative protein of 254 amino acids that is highly homologous to triosephosphate isomerase. The cDNA was isolated by subtractive hybridization and was differentially expressed in the remnant rat ileum after massive small bowel resection. The novel triosephosphate isomerase was named rsTPI (resection-induced TPI) and the putative protein encoded RSTPI. The nucleotide and amino acid sequences of rsTPI and RSTPI were about 60% and 62% homologous to Giardia lamblia TPI and TPI, respectively. Active catalytic sites (Lys 13, His 95, and Glu 167) and the peptide motifs, AYEPVWSIGT and GGASLKPEF found in other triosephosphate isomerases were conserved in RSTPI. rsTPI expression was detected in normal ileum and pancreas by reverse transcription-polymerase chain reaction. Expression of rsTPI in remnant rat ileum was detectable by northern blot analysis one week after massive small bowel resection. Expression increased significantly by 2.8 fold between one and two weeks after surgery. High levels were maintained for at least one month after surgery. The up-regulation of triosephosphate isomerase expression in the remnant small intestine after massive resection indicates that it may play an important role in the adaptive process. PMID- 9952220 TI - Characterization of early developmental pattern of expression of neurotensin/neuromedin N gene in foregut and midgut. AB - The gut endocrine gene, neurotensin (NT/N), is expressed in a strict temporally and spatially specific pattern. Utilizing a sensitive reverse transcription polymerase chain reaction procedure, we analyzed foregut and midgut organs for NT/N expression, determined the earliest apparent time point that NT/N is expressed in the gastrointestinal tract and compared the temporal relationship of NT/N with other genes. NT/N expression was detected in the fetal and early postnatal stomach. In the small bowel, NT/N was expressed at the earliest fetal time (14 days) that the small bowel could be reliably delineated from other gut organs; in contrast, expression of sucrase-isomaltase was only apparent at 28 days after birth. NT/N was expressed in the fetal (12, 14 and 16 days) liver and then again on days 3 and 7 after birth; however, NT/N was detected only in the fetal (14 and 16 days) pancreas. Finally, NT/N expression was first detected at approximately 12 days gestation in the primitive foregut and midgut, thus occurring significantly earlier than actual intestinal cytodifferentiation. NT/N is widely expressed in the gastrointestinal tract during fetal development, suggesting the presence of a shared ancestral stem cell; NT/N expression is then restricted to the small bowel of the adult. The determination of the cellular factors regulating the expression of NT/N will provide a better understanding of the mechanisms responsible for the strict patterning of gene expression in the gastrointestinal tract and possibly gut differentiation. PMID- 9952221 TI - The utilization of colon transit scintigraphy in the diagnostic algorithm for patients with chronic constipation. AB - We performed a retrospective utilization study covering a four-year period to determine how physicians familiar with colon transit scintigraphy (CTS) use it to manage patients with chronic constipation. Following CTS, there was a change is both frequency and likelihood of diagnosis. The diagnosis was changed in 51% of patients-37% of those considered to have slow transit constipation (STC) before CTS, 43% with obstructed defecation, and 64% with functional bowel disease (FBD). CTS increased the diagnostic likelihood in all groups. Of patients with the diagnosis of STC, 16% were considered "almost certain" before CTS while 83% were considered "almost certain" after CTS. For FBD comparable percentages were 13% and 62%. CTS may play a major role in the diagnostic work-up of patients with chronic constipation, both altering diagnosis and increasing diagnostic certainty. PMID- 9952222 TI - Respiratory distress during mesalamine therapy. PMID- 9952223 TI - Effect of acute hyperglycemia on jejunal compliance and peristaltic reflex in healthy humans. AB - Acute hyperglycemia has been shown to affect gastric motor function and colonic peristaltic reflex, but little is known about its effects on the small bowel. Our aim was to determine the effect of experimentally induced acute hyperglycemia on small bowel compliance and peristaltic reflex. Ten healthy subjects were studied during euglycemia and induced hyperglycemia. Sequential balloon inflation in the jejunum was used to determine pressure-volume relationships. The frequency of jejunal contractions and motility index proximal and distal to a distending balloon were measured for assessment of the peristaltic reflex. The intestinal pressure-volume relationship was not affected by hyperglycemia (In pressure/volume 0.084+/-0.006 vs 0.096+/-0.006, P = 0.19). During hyperglycemia, there was significantly more distal inhibition of frequency of contractions (51.0+/-26.6% vs 26.7+/-22.3%, P < 0.05) and of motility index (18.8+/-10.8% and 10+/-6.4, P < 0.05) in response to balloon inflation. We conclude that in the small bowel of healthy subjects, experimentally induced acute hyperglycemia has no effect on compliance and little effect on enteric nerve function. PMID- 9952224 TI - Effects of electroacupuncture on gastric migrating myoelectrical complex in dogs. AB - The aim-of this study was to investigate the characteristics of the gastric slow wave during different phases of the migrating myoelectrical complex (MMC) and the effect of electroacupuncture on the MMC. The experiment was performed in eight hound dogs implanted with one pair of bipolar serosal electrodes 2 cm proximal to the pylorus. Gastric myoelectrical activity was recorded for three complete cycles of the MMC in two sessions, one with electroacupuncture at points ST36 and PC6 and the other at sham points. The acupuncture was performed for 30 min in phase I of the second cycle of the MMC. Spectral analysis was performed to compute the frequency and power (amplitude) of the gastric slow wave, whereas blind visual analysis was applied to compute the appearance of spike potentials and the length of each phase of the MMC. It was found that there was a significant difference in the frequency and power of the gastric slow wave during different phases of the MMC (P < 0.05). Phase I was characterized with the highest frequency and lowest power of the gastric slow wave, whereas phase III exhibited the highest power in the slow wave. It was also found that in comparison with the sham points, electroacupuncture at the acupoints increased the number of spike bursts. This increase was not significant during the MMC cycle with electroacupuncture (34.4+/-4.1 vs 27.5+/-2.5%, P > 0.05) but became significant during the cycle after electroacupuncture (39.8+/-3.3% vs 27.5+/ 2.5%, P < 0.0005). Similarly, during the MMC cycle after electroacupuncture at the acupoints, there was a significant decrease in the length of phase I (14.8+/ 2.2 vs 46.9+/-6.1 min, P < 0.003) and a significant increase in the length of phase II (75.6+/-9.9 vs 30.6+/-4.1 min, P < 0.003) and phase III (25.8+/-0.6 vs 22.1+/-0.7 min, P < 0.003). A similar increase was observed during the MMC cycle with electroacupuncture but was not statistically significant. In conclusion, the gastric slow wave has the highest power during phase III of the MMC, indicating that the antral contraction is characterized not only by the appearance of spikes, but also by the increased power of the slow wave. Electroacupuncture at acupoints of ST36 and PC6 enhances the gastric MMC by reducing the length of phase I and increasing the length of phases II and III. PMID- 9952225 TI - Factors affecting outcome following proximal and distal intestinal resection in the dog: an examination of the relative roles of mucosal adaptation, motility, luminal factors, and enteric peptides. AB - In the clinical setting, resection of the ileum results in an inferior functional outcome compared to jejunal resection. This may be related to a greater adaptive capacity of the ileum, intrinsic structural and functional differences, or regional differences in motor and hormonal function. Our aim was to evaluate the relative contributions of these factors to functional outcome after resection of the proximal or distal intestine. Twenty-four dogs underwent either intestinal transection or 50% resection of the proximal or distal intestine. Studies (nutritional status, absorption, adaptation, motility, peptide levels) were performed every four weeks until the animals were killed at 12 weeks. Caloric intake was similar in all four groups. Weight loss was greater and more sustained after distal resection (DR). Serum cholesterol levels decreased significantly only in the DR group. While stool weight and moisture were similar, the DR animals had persistent, significant steatorrhea. Intraluminal anaerobic bacteria and SCFA concentrations were significantly greater in the ileum but were not influenced by resection. Intestinal remnant length increased to a greater extent after proximal resection (PR), but circumference increased to a similar extent after both resections. Villus height and crypt depth increased significantly only after PR. MMC frequency was similar in all four groups. In the DR animals 26% of migrating motor complexes (MMCs) originated within the remnant. The jejunal remnant of these animals had a dominance of cluster activity similar to the intact distal ileum. Following PR, the postprandial motilin response was decreased. After DR, there were transient increases in neurotensin and PYY. Of the various factors evaluated, mucosal adaptation and the intestinal motor response appear most likely to explain the inferior nutritional and absorptive outcome associated with resection of the distal small intestine. PMID- 9952226 TI - Effect of 5-fluorouracil on gastrointestinal carcinogenesis induced by N-methyl N'-nitro-N-nitrosoguanidine in rats. AB - This study was undertaken to determine the effect of 5-fluorouracil on gastrointestinal carcinogenesis. Sixty rats were divided into three groups of 20 rats each. All rats were exposed to N-methyl-N'-nitro-N-nitrosoguanidine for the first 20 weeks. Group 1 rats received intraperitoneal injections of 5 fluorouracil for the first 20 weeks and were then observed for the second 20 weeks. Group 2 rats also received 5-fluorouracil injections, but for the second 20 weeks. Group 3 rats received no 5-fluorouracil treatment. Four of 20 rats in group 1 developed an invasive adenocarcinoma. In group 3, invasive squamous cell carcinoma and adenocarcinoma developed in one rat each. None of the group 2 rats had malignant lesions. These results suggested that 5-fluorouracil is not effective in suppressing the initial stage of gastrointestinal carcinogenesis with a coexisting carcinogen. Rather, the therapeutic effect is exerted in later stages of tumor progression. PMID- 9952227 TI - Effect of pancreatic juice reflux into biliary tract on N-nitrosobis(2 oxopropyl)amine (BOP)-induced biliary carcinogenesis in Syrian hamsters. AB - To elucidate the possible role of pancreatic juice reflux into the biliary tract in promoting the development of biliary carcinoma, Syrian hamsters were subjected to cholecystoduodenostomy and ligation of the distal end of the common duct and then subcutaneously injected with N-nitrosobis(2-oxopropyl)amine (BOP) (experimental group). The incidences of gallbladder carcinoma and extrahepatic bile duct carcinoma in the experimental group was significantly higher than in the sham-operated group (P < 0.01, P < 0.05). The proliferating cell nuclear antigen (PCNA) labeling indices of both regions gradually increased with time, and were significantly higher in the experimental group at weeks 9 and 16 than in the sham-operated group at the same time. Trypsin and phospholipase A2 (PLA2) activities in bile and tissue levels of superoxide dismutase (SOD) in the gallbladder and extrahepatic bile ducts were higher in the experimental group than in the sham-operated group. These findings suggest that the carcinogenic effect of BOP was enhanced in biliary epithelium that had proliferated in response to and/or had been injured by activated pancreatic enzymes refluxing into the biliary tract and then increased free radical activity, leading to a high frequency of carcinoma development in the biliary tract. PMID- 9952229 TI - Helicobacter pylori infection in elderly people: does quantitative serological testing predict gastroduodenal ulcer disease? AB - Invasive diagnosis of peptic ulcer disease in the aged often carries an increased risk. Recently a correlation between high IgG serum antibody concentrations against H. pylori and a clinical diagnosis has been reported. In this study, we attempted to establish a relationship between the magnitude of serum IgG antibody to H. pylori and the endoscopic diagnoses in H. pylori-infected elderly patients. All the patients aged 60 or older were entered into the study prospectively. Those patients who had ulcerogenic medications or H. pylori eradication therapy prior to testing, or who were seronegative for H. pylori were excluded. Endoscopic diagnoses included duodenal ulcer, gastric ulcer, presence of both gastric ulcer and duodenal ulcer, gastroduodenal erosions, and nonulcer dyspepsia. H. pylori IgG serology was determined by an enzyme-linked immunosorbent assay with values of greater than 50 units/ml being seropositive. In all, 182 seropositive elderly patients were recruited. The age was 68.8+/-6.7 (mean+/-SD) years (range = 60-94 years). The serum IgG titers ranged from 51 units/ml to 800 units/ml with a peak frequency at 50-99 units/ml (30.8%). The quantitation of H. pylori IgG values and the endoscopic diagnoses failed to demonstrate any relationship of statistical significance. Our results indicate that the magnitude of H. pyloni IgG serology cannot be used to predict the presence or absence of peptic ulcer disease in the elderly. PMID- 9952228 TI - Adenocarcinoid of ileum and appendix, incidentally discovered during exploratory laparotomy for gastric MALT lymphoma, with subsequent diffuse prostatic metastases: report of a case with light, immunohistochemical, and electron microscopic studies. AB - The diagnosis of adenocarcinoid (mucinous/goblet cell carcinoid) is usually unexpected by both clinicians and pathologists. We report here the case of a 74 year-old man with gastric lymphoma (B-cell MALToma) diagnosed by endoscopy, who was found on exploratory laparotomy also to have extensive intraabdominal involvement by adenocarcinoid, arising from the ileum and/or appendix. The patient died two years after diagnosis with bladder outlet and small bowel obstruction due to diffuse metastases. In addition to mucin positivity, immunohistochemical stains demonstrated the tumor to be positive for chromogranin, synaptophysin, serotonin, gastrin, and glucagon. Of histogenetic interest, some individual neoplastic cells appeared to be positive for both mucin and chromogranin, and this was confirmed by the electron microscopic finding of microvilli, intracytoplasmic mucin droplets, and neurosecretory granules involving the same neoplastic cells. This also appears to be the first reported case of adenocarcinoid associated with lymphoma and demonstration of histochemical/immunohistochemical and ultrastructural evidence of cellular components with dual mucinous adenocarcinoma and neuroendocrine features, and the second reported case to have prostatic metastases. PMID- 9952230 TI - One stomach--one strain: does Helicobacter pylori strain variation influence disease outcome? AB - The aim of the study was to determine inter- and intrapatient variation of Helicobacter pylori strains based on genomic fingerprinting and cagA (cytotoxin associated gene A) status. Ten bacterial colonies from each of 10 patients with gastric cancer (GC), 10 with duodenal ulcer (DU), and 10 with gastritis (GI) were used. The presence of the putative adhesin gene, the cagA gene, and the strain specific banding pattern obtained by arbitrary primed (AP-) PCR was analyzed. Genomic fingerprinting showed extensive interpatient variation, but the banding patterns obtained from colonies from the same patient were always identical (intrapatient variation). In five patients, the cagA status varied between the colonies despite identical banding patterns. Among patients in a developed country such as Sweden, the proportion with multiple-strain infection of H. pylori is low, but subclones with differing cagA status exist within the strain. PMID- 9952231 TI - Attenuation of hydrophobic phospholipid barrier is an early event in Helicobacter felis-induced gastritis in mice. AB - Helicobacter pylori infection has been linked to the development of gastritis which can then progress to a number of disease entities including peptic ulcer disease and gastric cancer. Since the pathogenic mechanism by which the bacteria causes gastritis is unresolved, we employed a model system, the H. felis-infected mouse to investigate the temporal relationship between bacterially-induced alterations in the hydrophobic phospholipid barrier of the stomach and the development of gastritis. In the present study, C57BL/6 mice were inoculated with 10(9) CFU of H. felis and the changes in gastric wet weight, histology, surface hydrophobicity, phospholipid/phosphatidylcholine concentration, phospholipase A2 activity, and the pH of collected gastric juice were measured 0.5-2 months postinoculation. In related experiments, we investigated the effects of treating H. felis infected mice with antibiotic/ bismuth therapy on the above gastric properties. It was determined that both gastric surface hydrophobicity and phospholipid composition were significantly attenuated as early as 2-4 weeks postinfection, preceding signs of mucosal inflammation and glandular atrophy as indicated by increases in gastric wet weight, pH and a disappearance in parietal cells. These early H. felis-induced changes in gastric surface hydrophobicity and phospholipid concentration were reversed by antibiotic/bismuth therapy. Based on these results we conclude that H. felis infection induces an early transformation of the stomach from a hydrophobic to an acid-sensitive hydrophilic state that may trigger the subsequent development of gastritis. PMID- 9952232 TI - Reactions from rat gastric mucosa during one year of Helicobacter pylori infection. AB - The aim of the present study was to investigate responses from the gastric mucosa of rats during long-term H. pylori infection. Twenty-four Sprague-Dawley rats were inoculated with a mouse-adapted strain of human H. pylori (vacA+, cagA+), 16 uninfected rats served as controls. Three to six rats from each group were killed two weeks or two, six, or 12 months later. At sacrifice, blood was sampled and the gastric mucosa was taken for bacterial culture, histology, immunocytochemistry and in situ hybridization. H. pylori colonized the antrum in 23/24 inoculated rats; with time the density of bacteria increased. The inflammation in the antral mucosa was mild to moderate and was dominated by infiltration of lymphocytes and macrophages. Serum H. pylori-specific IgG2a was significantly increased in the infected rats. The frequency of epithelial cell apoptosis was significantly increased in the early months of infection. The mucosal expression of trefoil peptide mRNA remained unchanged. We conclude that after one year of H. pylori infection in rats, the mucosal responses were rather mild, indicating that the animals may adapt to the infection by mechanisms which remain to be identified. PMID- 9952234 TI - Histological esophagitis: clinical and histological response to omeprazole in children. AB - Many children with esophagitis demonstrate histological changes without gross evidence of esophagitis by esophagoscopy. The effect of omeprazole on the histological healing of esophagitis in children is unknown. Therefore, the aim of this study was to determine the effect of omeprazole on refractory histological esophagitis in pediatric patients. Eighteen patients with histological evidence of esophagitis and recurrent symptoms despite therapy with H2-receptor antagonists and prokinetic agents were prospectively treated with omeprazole. Dosing was adjusted by monitoring intragastric pH, and esophagoscopy was repeated after 8-12 weeks of omeprazole treatment. Two patients did not complete the study due to either worsening symptoms or hypergastrinemia. Of the remaining patients, 76% were asymptomatic with omeprazole treatment and 24% reported improvement in their symptoms. Approximately 40% demonstrated complete histological healing of their esophagitis. Three patients (17%) had persistent elevations in serum gastrin levels while on omeprazole treatment, which was associated with both younger patient age and higher omeprazole dosing; however, all elevated gastrin levels returned to normal after discontinuation of the medication. All patients had recurrence of their symptoms after completing a course of omeprazole, even patients with complete histological healing. Omeprazole is efficacious in treating children with esophagitis refractory to H2-receptor antagonist and prokinetic agents. However, none of the patients were able to discontinue acid suppressive therapy even after documented healing of their esophagitis. PMID- 9952233 TI - Healing of severe esophagitis improves esophageal peristaltic dysfunction. AB - Reflux esophagitis is frequently associated with peristaltic dysfunction, which increases with the severity of inflammatory lesions. In order to assess peristaltic dysfunction with more accuracy before and after healing, we used a 24 hr pH and pressure recording method. Nineteen patients (median age: 65, range: 33 77) with stage II and III (Savary-Miller classification) esophagitis and peristaltic dysfunction were treated with 40 mg omeprazole for three to six months until complete endoscopic healing was achieved. Before treatment, median contraction amplitude was significantly lower than median contraction amplitude of a control group of comparable age [31 (21-53) versus 42 (21-77) mm Hg, P < 0.01], as well as median percentage of peristaltic contractions [27 (16-63) versus 44 (11-56), P < 0.01]. At the end of treatment, a statistically significant improvement of esophageal motor functions was observed for both median contraction amplitude [38 (26-55), P = 0.001] and median percentage of peristaltic waves [45 (23-68), P = 0.0001]. The posttreatment values, although still low, were not significantly different from control values. In conclusion, complete healing of grade II and III esophagitis improves peristalsis. Inflammatory processes related to severe esophagitis may be involved in failed peristalsis and low contraction amplitude. PMID- 9952235 TI - Symptomatic gastroesophageal reflux in acutely hospitalized patients. AB - Patients admitted acutely to hospital may be at risk of increased morbidity and mortality as a result of gastroesophageal reflux and its complications. The recognized association of gastroesophageal reflux with cardiac and respiratory disease, the use of drugs that reduce lower esophageal sphincter pressure, and the supine position in which many patients are nursed may increase the risk of gastroesophageal reflux. This study aimed to determine the prevalence and severity of refluxlike symptoms in a series of consecutive unselected patients admitted acutely through the accident and emergency department of a district general hospital and to study the effect of hospitalization on these symptoms. Patients were interviewed by questionnaire on two occasions: immediately following admission and again 7-10 days later. The frequency of symptoms of heartburn, acid regurgitation, dysphagia, nausea, and belching were recorded on a 6-point scale, in addition to whether these symptoms occurred at night. Medication history, the number of days spent on bed rest, nasogastric intubation, and operation history were also recorded. In all, 275 patients were interviewed, of whom 229 had a second interview; 27% (62) had symptoms at least once a week (49% reported symptoms at least once a month) prior to admission, of whom 4% (9) had daily heartburn and/or acid regurgitation. Following admission to hospital there was a significant (P < 0.001) fall in the prevalence and frequency of refluxlike symptoms. There was a significant association of refluxlike symptoms with number of days spent in bed (P < 0.05) and with the use of nonsteroidal antiinflammatory drugs in hospital (P < 0.0001). Logistic regression analysis confirmed the association of NSAIDs with refluxlike symptoms. Nasogastric intubation and surgery were not associated with heartburn. In conclusion, symptoms of heartburn and acid regurgitation become less frequent following admission to hospital. This probably relates to a reduction in physical exertion following hospital admission but may reflect a reduction in anxiety levels or treatment of underlying disease. Patients on prolonged bed rest and those given non-steroidal anti-inflammatory drugs are at increased risk of refluxlike symptoms and may require antireflux measures. PMID- 9952236 TI - Relationship of portal pressure and colorectal vasculopathy in patients with cirrhosis. AB - We studied the relationship between portal pressure and colorectal mucosal vascular lesions in cirrhotics and the effectiveness of drug therapy in treating these lesions. Colonoscopy and hepatic venous pressure gradient (HVPG) studies were performed in 21 cirrhotics. Oral spironolactone plus transdermal nitroglycerin were given to patients who had diffuse mucosal cherry-red spots and/or rectal varices. The colonoscopy and HVPG determinations were repeated after four weeks. Colonoscopic findings included vascular ectasias in 13 patients (62%), diffuse cherry-red spots in the rectum in five patients (24%), and rectal varices in eight patients (38%). Overall, colorectal mucosal vascular lesions were found in 16 cirrhotics (76%). These findings were not found in 21 age- and sex-matched noncirrhotic controls. Vascular ectasias appeared without relationship to the HVPG. Patients with diffuse cherry-red spots (N = 5, 22.4+/ 3.4 mm Hg) had a significantly higher HVPG than those without (N = 16, 16.6+/-3.3 mm Hg, P < 0.01). However, no significant difference was found in HVPG between patients with rectal varices (N = 8, 19.4+/-4.6 mm Hg) and patients without rectal varices (N = 13, 17.2+/-3.8 mm Hg). After four weeks of drug therapy, diffuse cherry-red spots became less obvious when the HVPG decreased more than 20%. Rectal varices did not change their appearance with HVPG reduction. We found that colorectal vascular lesions are common in cirrhotics. Diffuse cherry-red spots are probably dependent on elevated portal pressure, but vascular ectasias and rectal varices are not related to the degree of portal pressure. Chronic drug therapy with reduction of portal pressure improves colonoscopic findings such as diffuse cherry-red spots. PMID- 9952237 TI - Portohepatic gradient and portal hemodynamics in patients with cirrhosis due to hepatitis C virus infection. AB - We evaluated the agreement between wedged hepatic vein pressure (WHVP), portal vein pressure (PVP), and its relationship with portal hemodynamics in 21 patients with HCV-related cirrhosis with esophageal varices. Direct measurements of the portohepatic gradient (HVPG) were obtained by ultrasound-guided fine needle puncture of the right hepatic and the portal veins. In five cases PVP was 6.4 10.4 mm Hg higher than WHVP. In 12 cases measurements were similar (WHVP - PVP < or = 3 mm Hg). In the remaining four cases WHVP was 3.6-9.6 mm Hg higher than PVP. WHVP and PVP agreement was not related to HVPG mean value, Child-Pugh score, or grading of esophageal varices. By contrast, the difference between WHVP and PVP was inversely related to the portal flow velocity (P = 0.053) and directly related to the portal vascular resistance (P = 0.02). Whereas the portal branches were visualized in patients with WHVP lower or similar to PVP, a predominant left portosystemic collateral flow was observed in patients with WHVP > PVP. Our data point out that, in patients with cirrhosis due to hepatitis C virus infection, discrepant HVPG values reflect true hemodynamic differences. PMID- 9952238 TI - Serum soluble interleukin-2 receptor levels before and during interferon treatment in patients with chronic hepatitis B virus infection. AB - To determine the role of serum soluble interleukin-2 receptor (sIL-2R) in chronic hepatitis B virus (HBV) infection, the level of serum sIL-2R was measured in sera of 105 patients with chronic HBV infection and in 21 healthy controls, using enzyme-linked immunosorbent assay. Serum sIL-2R levels were significantly higher in chronic HBV-infected patients with chronic hepatitis (508+/-310 units/ml) and liver cirrhosis (543+/-283 units/ml) than in healthy controls (331+/-106 units/ml, P < 0.05). Moreover, serum sIL-2R levels were significantly higher in patients with chronic hepatitis or liver cirrhosis than in asymptomatic HBV carriers (341+/-150 units/ml, P < 0.01). There was no difference in serum sIL-2R levels between asymptomatic HBV carriers and healthy controls or between patients with chronic hepatitis and liver cirrhosis. A significant relationship was found between serum sIL-2R and ALT levels (P < 0.05) in patients with chronic HBV infection, although there was no correlation between sIL-2R and HBV DNA levels. Serum sIL-2R levels in most patients decreased to the same level as asymptomatic HBV carriers and healthy controls at 48 weeks after the end of treatment, and serum ALT and HBV DNA levels were decreased to within the normal range at 96 weeks. Thus, serum sIL-2R levels indicate the degree of liver damage among patients with chronic HBV infection. The serum sIL-2R levels one year after interferon administration may be a useful marker of determined at the effectiveness by this treatment. PMID- 9952239 TI - Further studies on aminopeptidase-M in blood in children with cholestatic liver diseases and viral hepatitis. AB - Aim of this study was to determine and further characterize the serum aminopeptidase-M in children with liver diseases. Based on our new assay, we have shown two fractions of the enzyme. Activity of the first fraction is expressed in undiluted serum at pH adjusted from 8.5 (pH of storaged serum) to 7.4. Activity of the second fraction (cryptic activity) appears in the serum (pH 7.4) as a result of dilution and/or addition of aniline naphthalene sulfonic acid. In children with Alagille syndrome, extrahepatic biliary duct atresia, Byler's disease, and acute hepatitis due to hepatitis B virus infection, activities of both fractions are highly elevated as compared to healthy children or those with chronic viral hepatitis. Moreover, serum aminopeptidase-M seems to reflect other aspects of the pathological process than those reflected by the alanine aminotransferase and gamma-glutamyltranspeptidase. Due to increased activity and broad substrate specificity, the enzyme seems to be also a cofactor of cholestasis and hepatitis. PMID- 9952240 TI - Transjugular liver biopsy in 52 patients with an automated Trucut-type needle. AB - A three-year prospective study was conducted to assess the efficacy and safety of transjugular liver biopsy with a Trucut-type needle employing an automated device. Fifty-two consecutive patients (39 women and 13 men), ages 46.3+/-14.6 years, in whom percutaneous liver biopsy was contraindicated were included in the study. An 18-gauge transjugular hepatic needle with a 20-mm throw length, a cutting cannula at the distal end, and an automated trigger device on the proximal end was used. All procedures were performed under fluoroscopic control, and the following variables were assessed: (1) number of passes, (2) size and average number of the obtained fragments, (3) number of portal triads, and (4) adequacy of the specimen for histologic diagnosis. The procedure was successful in 49/52 patients, and all samples obtained were satisfactory for histologic analysis even when cirrhosis or bridging fibrosis were present. Mean biopsy specimen length was 1.7+/-0.88 cm; mean number of passes was 2.42+/-1.01, the mean number of biopsy fragments and portal triads per attempt were 2.5+/-1.01 and 6.24+/-3.18, respectively. No major complications were observed. Transjugular hepatic biopsy with this new cutting system is an effective and safe procedure in patients with contraindication for percutaneous liver biopsy. PMID- 9952241 TI - Effect of octreotide (Sandostatin 201-995) on bile flow and bile components. AB - Octreotide (Sandostatin 201-995) has an inhibitory effect on gastric, intestinal, and pancreatic secretions and hepatic and splachnic blood flow. We examined the effects of octreotide on bile flow and bile components in 10 patients with T-tube choledochostomy. A Fogarty balloon catheter was inserted distal to the T-tube of these patients for measurement of bile flow and bile components. Bile samples were obtained to analyze bile acid, phospholipid, lipoprotein, and cholesterol, and bile flow measurements were performed every 15 min for a period of 90 min before study and after normal saline and octreotide administrations. While octreotide had an inhibitory effect on bile flow, the concentrations of bile acid, phospholipid, and lipoprotein in bile were increased with octreotide. PMID- 9952242 TI - Myasthenia gravis: another autoimmune disease associated with hepatitis C virus infection. AB - We report on a male Egyptian patient who developed myasthenia gravis with typical symptoms, beneficial response to pyridostigmine, and the presence of anti acetylcholine receptor antibodies and anti-striated muscle antibodies during the course of a chronic hepatitis C infection complicated by liver cirrhosis. As also reported for the herpes simplex and for the HIV virus, hepatitis C may lead to myasthenia gravis via a mechanism of cross-reactivity between viral epitopes and the acetylcholine receptor. PMID- 9952243 TI - Effects of ursodeoxycholic acid therapy on in vitro gallbladder contractility in patients with cholesterol gallstones. AB - During treatment with ursodeoxycholic acid (UDCA), the fasting gallbladder volume increases by a yet unknown mechanism. The present study tests whether in vitro human gallbladder contractility in response to acetylcholine and cholecystokinin is affected by UDCA therapy. Gallbladder tissue was obtained from 15 patients treated with UDCA (10 mg/kg/day) during three weeks prior to surgery, and from 15 comparable patients not treated. Data were correlated with in vivo contractility, bile composition, and gallbladder wall inflammation. The inflammation score was lower in the treated patient group. UDCA treatment enhanced gallbladder contractility in vitro: Dose-response curves for acetylcholine and cholecystokinin were both shifted to the left, and the maximal contractile stress generated in response to cholecystokinin was higher in the treated group, whereas the maximal acetylcholine-induced stress was not increased. Maximal cholecystokinin-induced stress correlated positively with fasting gallbladder volume and negatively with the biliary cholesterol saturation index, but not with bile salt hydrophobicity or gallbladder wall inflammation score. In conclusion, UDCA treatment improves in vitro gallbladder contractility, possibly related to a reduced biliary cholesterol saturation. Increased fasting gallbladder volumes during UDCA treatment thus do not appear to result from decreased gallbladder muscle contractile strength. PMID- 9952244 TI - Partial characterization of mechanisms of cytoprotective action of hydrophilic bile salts against hydrophobic bile salts in rats: relation to canalicular membrane fluidity and packing density. AB - Bile salts regulate the subselection of phosphatidylcholine species secreted into bile and thereby modulate bile metastability. The aim of this study was to determine whether bile salts alter phosphatidylcholine species of the canalicular membrane, and if they do, to clarify whether the cytoprotective action of hydrophilic bile salts is associated with modulation of phosphatidylcholine composition in cell membrane bilayers. Bile salt-pool-depleted rats were infused intravenously with sodium taurocholate at a constant rate (200 nmol/min/100 g body wt) for 2 hr, followed by infusion of either sodium tauroursodeoxycholate, sodium tauroalphamuricholate, or sodium taurobetamuricholate (200 nmol/min/100 g) for 2 hr. Biliary outputs of cholesterol and phosphatidylcholine and phosphatidylcholine hydrophobicity in bile and subcellular fractions were determined. The cytoprotective action of hydrophilic bile salts was determined by the release of canalicular membrane-localizing enzymes (alkaline phosphatase, leucine aminopeptidase) into bile. Tauroursodeoxycholate, taurobetamuricholate, and tauroalphamuricholate decreased the release of these enzymes when compared to values under taurocholate infusion. Bile phosphatidylcholine hydrophobicity was also decreased by the bile salts, whereas the cholesterol/phosphatidylcholine ratio was increased. In contrast, phosphatidylcholine hydrophobicity in the canalicular membrane was increased by these three bile salts. In conclusion, hydrophilic bile salts promote biliary secretion of relatively hydrophilic phosphatidylcholine secretion into bile, and consequently phosphatidylcholine hydrophobicity in canalicular membranes increased. Such an alteration in phosphatidylcholine species within canalicular membrane enhances its lateral packing density with less fluidity, and this may account, in part, for the cytoprotective action of hydrophilic bile salts against hydrophobic bile salts. PMID- 9952245 TI - Biliary sludge and pigment stone formation in bile duct-ligated guinea pigs. AB - We studied the effects of bile stasis in a guinea pig model of pigment gallstone. The common bile ducts of guinea pigs were partially ligated, and the guinea pigs killed one or two weeks later. Biliary sludge or stones were examined with the Fourier transform infrared spectroscopy and the scanning electromicroscopy. The bile was analyzed for pH, free calcium, bile acids and bilirubin fractions, and the activities of both bacterial and endogenous beta-glucuronidase. After bile duct ligation, calcium bilirubinate precipitates or stones formed in all except one of the animals studied. The bile pH and the proportion of unconjugated bilirubin rose after bile duct ligation, with a concomitant fall of bilirubin monoglucuronide. The activity of bacterial beta-glucuronidase decreased after ligation, while the activity of endogenous beta-glucuronidase rose at week 2. Our results imply that precipitation of calcium bilirubinate in this animal model was induced by an increased bile pH and the nonenzymatic hydrolysis of conjugated bilirubin. PMID- 9952246 TI - Fecal elastase 1 determination in chronic pancreatitis. AB - This study assessed the diagnostic accuracy of fecal elastase 1 in chronic pancreatitis. Fifty-three healthy subjects, 44 patients with chronic pancreatitis (22 severe, 13 moderate, and 9 mild), and 43 patients with nonpancreatic digestive disease were studied. Elastase 1 concentration was determined on a small sample of feces using a commercially available kit. Fecal chymotrypsin was also measured. With a cutoff level of 190 microg/g, all healthy controls except one (98.1%), and the majority of patients with nonpancreatic digestive diseases (40 of 43; 93.0%) had elastase values above this limit. Among the 44 patients with chronic pancreatitis, 34 (77.3%) had pathological values: all 22 (100%) with severe disease, 10 of 13 (76.9%) with moderate disease and 2 of 9 (22.2%) with mild disease. Chymotrypsin values were pathological in 25 of 44 (56.8%) patients with chronic pancreatitis: 17 of 22 (77.2%) with severe pancreatitis, 7 of 13 (53.8%) with moderate pancreatitis, and 1 of 9 (11.1%) with mild disease. The specificity was 95.8% for elastase 1 and 85.4% for chymotrypsin. The difference both in sensitivity and specificity of the two enzymes was statistically significant (P < 0.05). Fecal elastase 1 has a high sensitivity, superior to that of fecal chymotrypsin, in the diagnosis of chronic pancreatitis. For its simplicity and rapidity, it could represent the tubeless test of choice in chronic pancreatitis. PMID- 9952247 TI - A 5-year follow-up study of generalized anxiety disorder and panic disorder. AB - To examine the course and outcome of subjects with generalized anxiety disorder (GAD) and panic disorder, we compared 64 patients with GAD and 68 patients with panic disorder who had participated in drug treatment studies and were interviewed an average of 5 years earlier. At baseline GAD subjects were significantly older, had an earlier onset, and longer duration of illness than panic subjects. GAD subjects also had less severe symptoms. At follow-up, diagnostic stability was observed for both GAD and panic disorder. Significantly fewer GAD subjects achieved full remission at follow-up (18% vs. 45%, p < .01). Subjects with GAD were significantly less anxious at baseline than the panic disorder comparison group, but at follow-up there were few significant differences between groups on most severity of illness variables. This change was due in great part to improvement in the panic disorder group with a concomitant lack of change in the GAD group. PMID- 9952248 TI - Suicide in patients hospitalized for schizophrenia: 1913-1940. AB - From a sample of 1357 schizophrenic patients hospitalized between 1913 and 1940 at the Phipps Clinic, we have follow-up data on 1212 (89%) cases, with a mean length of follow-up of 11 years. Of these 1212 patients, 28 (2%) are known to have committed suicide. Suicide was significantly correlated with 1) previous suicide attempts, 2) depressive symptoms, 3) preoccupation with suicide, 4) affective illness in close relatives, 5) poor premorbid social and work history, 6) sexual worries, and 7) psychomotor agitation. Marital status, gender, age at onset, age at admission, number of previous admissions, condition at discharge from Phipps, length of hospitalization, the presence of any type of delusions or hallucinations, alcohol problems, paranoid or catatonic features, and utilization of shock therapies were not significantly correlated with subsequent suicide. The seven variables significantly correlated with suicide enumerated above were chosen to construct a scale suggesting which patients were at high risk for suicide. PMID- 9952249 TI - Longitudinal course and predictors of continuing distress following critical incident exposure in emergency services personnel. AB - This study examines the longitudinal course and predictors of stress-specific and general symptomatic distress in emergency services personnel. A three-group quasi experimental design was used to determine the responses of 322 rescue workers to the Loma Prieta earthquake Interstate 880 Freeway collapse and to unrelated control critical incidents. Self-report questionnaires, including measures of incident exposure, peritraumatic dissociation and emotional distress, and current symptoms, were administered 1.9 years (initial) and 3.5 years (follow-up) after the freeway collapse. Despite modest symptom improvement at follow-up, rescue workers were at risk for chronic symptomatic distress after critical incident exposure. Peritraumatic dissociation accounted for significant increments in current posttraumatic stress disorder symptoms, over and above exposure, adjustment, years of experience, locus of control, social support, and general dissociative tendencies. The results suggest that rescue workers, particularly those with more catastrophic exposure and those prone to dissociate at the time of the critical incident, are at risk for chronic symptomatic distress. PMID- 9952250 TI - Gender differences in clinical correlates of suicidality among young adults. AB - Gender differences were examined in risk factors for suicidality among young adult friends of suicide victims. Data were derived from a follow-up community survey of 76 members of the social network of 23 consecutive adolescent suicide victims 6 years after the friend's death. The Beck-Kovacs Scale for Suicidal Ideation was the outcome measure. Multiple regression analyses revealed aggression to have the only significant effect on suicidality among men, whereas depression and posttraumatic stress disorder had significant independent effects on suicidality among women. Results suggest that young adult men who are aggressive and female subjects with elevated symptoms of depression and/or posttraumatic stress disorder may be at increased risk of suicidality. PMID- 9952251 TI - Perceived abuse and neglect as risk factors for suicidal behavior in adolescent inpatients. AB - The aim of this study was to assess relative risk of histories of different types of abuse (sexual, physical, and emotional) and neglect (physical and emotional) for suicidal behavior (attempts, ideation, and self-mutilation) in psychiatrically hospitalized adolescents. Seventy-one adolescent inpatients (34 boys, 37 girls) completed self-report measures of abuse and neglect, current suicidal ideation, and lifetime suicide and self-mutilation attempts. The prevalence of sexual and physical abuse was 37.5% and 43.7%, respectively, with 31.3% and 61% of youngsters reporting emotional and physical neglect. Fifty-one percent of youngsters had made suicide attempts, and 39% had self-mutilated. Suicide attempters were significantly more likely to be female, Latino, to report sexual, physical, and emotional abuse, and to endorse emotional neglect. In multivariate analyses, female gender, sexual abuse, and emotional neglect remained significant predictors of self-mutilation and suicidal ideation. Female gender and sexual abuse remained significant predictors of suicide attempts. These findings suggest that emotional neglect is an important and deleterious component of maltreatment experiences and may be a more powerful predictor of suicidal behavior in hospitalized adolescents than physical abuse, emotional abuse, and physical neglect. PMID- 9952252 TI - Dreams of personality disordered subjects. AB - Dreams provide access to underlying personality structure, defensive and adaptive functions, and they elucidate the psychological forces that lead to overt symptomatic behavior. Two hundred three dreams of 39 personality disordered patients were factor analyzed and compared with Hall and Van de Castle's normative data (Hall C, Van de Castle RI [1966] The content analysis of dreams. New York: Appleton-Century-Crofts). Results included a five-factor solution that sheds light on some core issues of the dreamers. Comparisons between the groups resulted in the personality-disordered group demonstrating more estrangement in their dreams, fewer interactions, and more emotionality. In their interactions, they demonstrated a lower ratio of aggressive interactions yet a higher tendency to view themselves as the aggressor. Results are related to theoretical literature on personality and defensive styles, mostly from a psychodynamic perspective. PMID- 9952253 TI - Alexithymia and attachment representation in idiopathic spasmodic torticollis. AB - We investigated alexithymia and the mental representation of attachment in idiopathic spasmodic torticollis (IST). It was hypothesized a) that alexithymia in IST is more prevalent than in a nonclinical control group and b) that significant correlations emerge between alexithymia and a dismissing attachment representation. Twenty patients with IST and 20 healthy controls matched for age and sex were administered the Toronto Alexithymia Scale (TAS-20) and the Adult Attachment Interview (AAI). Attachment was classified using the Attachment Interview Q-sort. IST patients scored significantly higher on the measure of alexithymia than subjects in the comparison group. In IST a dismissing attachment representation was significantly more frequent than in the control group. Across the total sample, externally oriented thinking correlated positively with dismissing attachment, and both externally oriented thinking and difficulty communicating feelings (two of the three subscales of the TAS-20) correlated inversely with secure attachment. Alexithymia is more prevalent in IST than in normals. As was hypothesized, alexithymia in adults is significantly interrelated with the mental representation of attachment. PMID- 9952254 TI - Enhancing medication compliance for people with serious mental illness. PMID- 9952255 TI - Dimensions of social adjustment in schizophrenia: a factor analysis. PMID- 9952256 TI - Some psychological and physical consequences in middle-aged adults of underfunded institutional care in childhood. PMID- 9952257 TI - Hippocampal and entorhinal cortex high-frequency oscillations (100--500 Hz) in human epileptic brain and in kainic acid--treated rats with chronic seizures. AB - PURPOSE: Properties of oscillations with frequencies >100 Hz were studied in kainic acid (KA)-treated rats and compared with those recorded in normal and kindled rats as well as in patients with epilepsy to determine differences associated with epilepsy. METHODS: Prolonged in vivo wideband recordings of electrical activity were made in hippocampus and entorhinal cortex (EC) of (a) normal rats, (b) kindled rats, (c) rats having chronic recurrent spontaneous seizures after intrahippocampal KA injections, and (d) patients with epilepsy undergoing depth electrode evaluation in preparation for surgical treatment. RESULTS: Intermittent oscillatory activity ranging from 100 to 200 Hz in frequency and 50-150 ms in duration was recorded in CA1 and EC of all three animal groups, and in epileptic human hippocampus and EC. This activity had the same characteristics in all groups, resembled previously observed "ripples" described by Buzsaki et al., and appeared to represent field potentials of inhibitory postsynaptic potentials (IPSPs) on principal cells. Unexpectedly, higher frequency intermittent oscillatory activity ranging from 200 to 500 Hz and 10-100 ms in duration was encountered only in KA-treated rats and patients with epilepsy. These oscillations, termed fast ripples (FRs), were found only adjacent to the epileptogenic lesion in hippocampus, EC, and dentate gyrus, and appeared to represent field potential population spikes. Their local origin was indicated by correspondence with the negative phase of burst discharges of putative pyramidal cells. CONCLUSIONS: The persistence of normal-appearing ripples in epileptic brain support the view that inhibitory processes are preserved. FRs appear to be field potentials reflecting hyper-synchronous bursting of excitatory neurons and provide an opportunity to study the role of this pathophysiologic phenomenon in epilepsy and seizure initiation. Furthermore, if FR activity is unique to brain areas capable of generating spontaneous seizures, its identification could be a powerful functional indicator of the epileptic region in patients evaluated for surgical treatment. PMID- 9952258 TI - A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. AB - PURPOSE: The purpose of this study was to test the hypothesis that a ketogenic diet would increase the resistance of rats to pentylenetetrazole (PTZ)-induced seizures and to understand the relation of ketonemia to seizure resistance. METHODS: A freely consumed, high-fat (ketogenic) diet was administered to male Sprague-Dawley rats for 5-10 weeks, while control animals were fed either rodent chow or a high-carbohydrate diet. Ketonemia was measured as plasma levels of beta hydroxybutyric acid (beta-OHB). Seizures were induced by tail-vein infusion of pentylenetetrazole. RESULTS: The ketogenic diet produced a highly significant (p<0.01) increase in beta-OHB levels within 5 days. Induction of seizures by PTZ 35 days after animals were placed on their respective diets showed that ketogenic animals had a significantly (p<0.01) increased threshold for seizure induction compared with those fed an isocaloric diet of either high-carbohydrate or normal rodent chow. Ketogenic animals did not exhibit increased seizure severity relative to controls, despite receiving consistently higher doses of PTZ. CONCLUSIONS: The ketogenic diet resulted in an increased seizure threshold, confirming the hypothesis, and seizure threshold was found to be a direct function of the level of ketonemia. PMID- 9952260 TI - Phenytoin penetration into brain after administration of phenytoin or fosphenytoin. AB - PURPOSE: This study was designed to measure the brain penetration of phenytoin (PHT) after intravenous (i.v.) administration of either standard PHT or fosphenytoin (FPHT), a PHT prodrug. The study was formulated to answer the question whether the time required for FPHT to be converted to PHT in the bloodstream would delay the accumulation of PHT in brain. METHODS: Four rats were sampled at various times after intravenous infusion of 30 mg/kg PHT i.v. or 30 mg/kg PHT equivalents of FPHT i.v. PHT was measured in serum, protein-free ultrafiltrate, and in brain, by using high-performance liquid chromatography. RESULTS: Although the initial PHT-free fraction was significantly higher for FPHT treated rats than it was for PHT-treated rats, brain PHT levels were significantly reduced after infusion of FPHT. CONCLUSIONS: When FPHT is used for treatment of generalized status epilepticus, it should be anticipated that lower initial brain PHT levels will be achieved than are typically found with standard PHT. PMID- 9952259 TI - Bidirectional transfer between electrical and flurothyl kindling in mice: evidence for common processes in epileptogenesis. AB - PURPOSE: This study sought to determine whether there was a transfer of seizure susceptibility between two models of epileptogenesis, electrical kindling and a newly described model of flurothyl kindling. In this study, we determined the effects of preexposure to one kindling agent on the seizure responsiveness to the other. METHODS: Mice were divided into three groups: (a) six mice (FLK) were kindled with flurothyl, rechallenged with flurothyl after a 28-day incubation phase, implanted with olfactory bulb (OB) electrodes, and electrically kindled; (b) six mice (ELK) were implanted with OB electrodes, electrically kindled to six stage 5 seizures, and given one flurothyl trial 3 days later and a second flurothyl trial after a 28-day incubation period; and (c) six mice (IMP) were implanted with OB electrodes, tested with flurothyl at the same times as the ELK group, and later electrically kindled. RESULTS: Mice that were previously kindled with flurothyl (FLK) had significantly faster electrical kindling rates to one stage 5 seizure or to six stage 5 seizures compared with animals in the ELK and IMP groups. Mice that were previously exposed to either electrical kindling or flurothyl kindling had significantly diminished latencies to generalized seizure onset (flurothyl-induced seizure thresholds) either before or after a 28-day incubation period compared with the IMP control mice. In addition, both the FLK and ELK groups had significantly increased percentages of mice expressing forebrain-brainstem seizures, compared with the IMP group, following either rechallenge with flurothyl after a 28-day incubation or focal electrical kindling. CONCLUSIONS: These findings indicate a near-complete bidirectional transfer between these electrical and flurothyl kindling models. Mice that were previously exposed to either electrical or flurothyl kindling have increased seizure susceptibilities and altered seizure phenotypes when exposed to the other seizure paradigm. Overall, these studies indicate that previous seizures are the critical determinant of the bidirectional transfer of seizure susceptibility observed, and not the electrical or pharmacologic properties of the original kindling agent. Finally, the observation of near identity in transfer characteristics between electrical and flurothyl kindling models suggests that the proepileptogenic processes initiated by exposure to either model are similar. PMID- 9952261 TI - The EEG and prognosis in status epilepticus. AB - PURPOSE: To examine the relation between specific EEG features and clinical outcome, determine whether a predictable sequence of EEG patterns exists during status epilepticus (SE), and examine the relation between periodic epileptiform discharges (PEDs) and SE. METHODS: EEG records of 50 patients with SE admitted to Graduate Hospital between January 1990 and July 1995 were reviewed. Ictal EEGs were available in 72%; 28% had only postictal EEGs. Poor outcome was defined as death or persistent vegetative state, and good outcome as all others. Fisher's Exact test, chi2, and t tests were performed for data analysis. RESULTS: Of 50 patients, 72% had a good outcome and 28%, a poor outcome. If PEDs were present at any time during or after SE, outcome tended to be worse (p = 0.053). With PEDs, eight (44%) of 18 had a poor outcome; without PEDs, six (19%) of 32 had a poor outcome. Etiologies for SE did not substantially differ in patients with or without PEDs, and structural abnormalities were not more associated with the presence of PEDs. PEDs were seen both early and late, during and after SE. Other EEG characteristics (lateralized vs. bilateral symmetric ictal EEG, discrete vs. continuous ictal activity, and postictal focal slowing) did not relate to outcome. No predictable sequence of EEG changes was found during SE. CONCLUSIONS: PEDs are the only EEG feature related to outcome in SE and are associated with poor outcome independent of etiology. PMID- 9952262 TI - Comparison of status epilepticus with prolonged seizure episodes lasting from 10 to 29 minutes. AB - PURPOSE: Status epilepticus (SE) is a major medical and a neurologic emergency associated with significant morbidity and mortality. The current definition of SE is continuous seizure activity or intermittent seizure activity without regaining consciousness, lasting > or =30 min. Epilepsy monitoring unit data indicate that many seizures self-terminate within minutes. Thus consideration was recently given to include seizure episodes lasting > or =10 min in the definition of SE. Because no large studies have been conducted on seizures lasting 10-29 min, this study was initiated to compare cases of SE and 10 to 29-min seizure episodes seen within the same period. METHODS: Patients seen at the Medical College of Virginia Hospitals of Virginia Commonwealth University over the same 2-year period were studied. Two hundred twenty-six prospective SE cases (91 children and 135 adults) and 81 retrospective 10- to 29-min seizure episodes (31 children and 50 adults) were compared. A standardized data-entry-form system was compiled on each patient and was used to evaluate the data collected. RESULTS: The 10- to 29-min seizure patients and the SE cases had similar demographic characteristics, such as sex, race, and age, and also had similar etiologies. The majority (93%) of SE cases required anticonvulsant (AED) treatment to control and stop seizure activity. In the 10- to 29-min group, 43% stopped seizing spontaneously, and the remainder (57%) required AED treatment to stop seizure activity. The mortality for the SE patients was 19% compared with 2.6% for 10- to 29-min group (p<0.001). In the 10- to 29-min group that stopped seizing spontaneously, the mortality was 0. In the 10- to 29-min patients that required AED treatment, the mortality was 4.4%. CONCLUSIONS: The results demonstrate that a significant number of patients experience seizure activity lasting from 10- to 29-min. Approximately half of these seizure events stopped spontaneously and did not require AED treatment. The other half of the patients responded quickly to medications and stopped seizing before the 30-min definition for SE. The overall mortality of this group was significantly lower than that of the patients with SE. The results demonstrate that further studies on the 10- to 29-min seizure group are needed to differentiate seizures that will stop spontaneously and those that will only stop with AED treatment. Because almost half of the prolonged seizures stopped spontaneously, further studies are needed before including prolonged seizure activity in the definition of SE. PMID- 9952263 TI - Interictal spikes increase cerebral glucose metabolism and blood flow: a PET study. AB - PURPOSE: In patients with reflex epilepsy, it is sometimes possible to evoke interictal spikes predictably, thus providing an uncommon but important experimental paradigm for examining the physiological changes produced by epileptiform discharges. METHODS: To examine the changes in regional cerebral blood flow (rCBF) and glucose consumption (rCMRglc) produced by interictal spikes, we performed positron emission tomography (PET) scans with the blood-flow tracer [15O]H20 and with [18F]fluorodeoxyglucose in a patient with fixation-off epilepsy. The scans were performed in states of high and low spike frequency produced by eye closure and opening, respectively. RESULTS: The rCBF study revealed a focal increase in blood flow associated with the state of increased interictal spiking. The focus was in the posterior portion of the left superior parietal lobule (Talairach coordinates: x: -36, y: -71, z: 39; t = 4.5; p<0.05) and corresponded to the site of maximal ictal EEG abnormality recorded with implanted electrodes. In a volume of interest of 10-mm diameter centered on the t statistic peak in the rCBF study, the mean rCMRglc was 39.1 micromol/100 g/min with eyes open and 44.1 micromol/100 g/min (13% increase) with eyes closed. An identical activation paradigm was used in six normal subjects studied with functional magnetic resonance imaging. In the normal subjects, no significant activation was observed in the parieto-occipital region, indicating that the changes observed in the patient were due to interictal spiking rather than to task performance alone. CONCLUSIONS: Interictal spiking produces focal increases in cerebral blood flow and glucose metabolism. PMID- 9952265 TI - Influence of valproate monotherapy on platelet activation and hematologic values. AB - PURPOSE: Valproate (VPA) has been linked to coagulation disturbances, with both impaired and exaggerated clotting, which has been attributed to an effect of VPA on platelets or hemostatic proteins. Additional thrombocytic function testing may help to identify patients at risk of increased bleeding caused by platelet dysfunction. METHODS: We evaluated the influence of VPA on hematologic routine values and platelet activation by using immunostaining and flow cytometry in 30 patients receiving long-term VPA therapy and in 30 controls. RESULTS: The fraction of activated platelets was similar in both groups; however, the general extent of platelet activation was significantly lower in the patient group, with considerable interindividual variability. In addition, patients had a significantly lower platelet count, prolonged thrombin time, and higher mean corpuscular hemoglobin. CONCLUSIONS: Our data confirm the previously reported hematologic changes caused by VPA and additionally suggest that VPA impairs procoagulatory thrombocytic function, which is reflected by reduced platelet activation and increased thrombin time. Possible mechanisms of VPA-platelet interaction are discussed. PMID- 9952264 TI - Profile of antiepileptic pharmacotherapy in a tertiary referral center in South India: a pharmacoepidemiologic and pharmacoeconomic study. AB - PURPOSE: To study the current pharmacotherapy practices of epilepsy and its economics in a developing country by correlating the epidemiology and economics of antiepileptic drug (AED) treatment in general epilepsy care and comprehensive epilepsy care. METHODS: We compared the AED-use profiles, efficacy, and tolerability at entry and at last follow-up for 972 patients seen at a comprehensive epilepsy care program in South India from 1993 to 1995. The relative cost was expressed as the average percentage of the per capita gross national product (GNP/capita) each individual spent for AED treatment. RESULTS: At entry, 562 (57.8%) subjects were receiving polytherapy; at last follow-up, 743 (76.4%) patients were receiving monotherapy, an increase of 34.3% in the use of monotherapy. One or more adverse drug reactions were reported by 28.6% of patients at entry and by 19.8% at last follow-up. The proportion of patients who were seizure free increased from 29.0 to 44.8%. Carbamazepine (CBZ) was the most frequently used AED, followed by diphenylhydantoin (DPH), valproate (VPA), and phenobarbitone (PB). The relative cost (% GNP/capita) for standard AEDs were as follows: PB, 4.4%; DPH, 7.1%; CBZ, 16.8%; and VPA, 29.5%. The average annual cost of AED treatment per patient in U.S. dollars was $64.32 at entry and $47.73 at last follow-up. Reduction in polytherapy resulted in the net annual saving of $16,128 ($16.59 per patient, or 5.4% GNP/capita). CONCLUSIONS: The more frequent use of relatively expensive drugs like CBZ and VPA and the use of polytherapy still quite prevalent in developing countries-has escalated the cost of AED therapy. Although in recent years AEDs have become more available in developing regions, primary and secondary care physicians have not been adequately educated about the current trends in the pharmacotherapy of epilepsy. PMID- 9952266 TI - Adjustment of carbamazepine dose to offset the effects of the interaction with remacemide hydrochloride in a double-blind, multicentre, add-on drug trial (CR2237) in refractory epilepsy. AB - PURPOSE: The efficacy of remacemide hydrochloride (REM) as an antiepileptic drug (AED) was tested in a double-blind, add-on trial in patients with refractory epilepsy. Concurrent drugs included carbamazepine (CBZ). The interfering effects of the pharmacokinetic interaction between REM and CBZ were offset by the monitoring of plasma CBZ concentration and the appropriate reduction of CBZ dose by an unblinded observer. METHODS: Patients taking CBZ entered a 4-week run-in period to stabilise their dosage regimen to Tegretol tablets and blinded capsules containing Tegretol tablets. They then entered an 8-week baseline period during which variation of plasma CBZ concentration was used to derive an individual Shewart Control Chart for each patient. These charts were used to define the threshold for CBZ dose reduction after the addition of trial drug. Where necessary the unblinded observer adjusted that portion of the daily dose of CBZ concealed in the opaque capsules, thereby maintaining the blind for the investigator and the patient. RESULTS: CBZ dosage reductions ranging from 14 to 50% were required by 63% of patients who received REM. Substantial increases in plasma CBZ concentration, which would have confounded the results of the trial, were thus avoided. The small increases in CBZ concentration that occurred in spite of this procedure were of similar magnitude in responders (patients who experienced > or =50% reduction in seizure frequency during treatment) and nonresponders, and in both groups the mean increase was <1 mg/L. CONCLUSIONS: The method is offered as a model solution for problems caused by pharmacokinetic interactions in add-on trials. PMID- 9952267 TI - Antiepileptic drug therapy and sexual function in men with epilepsy. AB - PURPOSE: To study the effects of antiepileptic drugs (AEDs) on sex hormone levels and sexual activity in a group of men attending a hospital-based epilepsy clinic. METHODS: One hundred eighteen men being treated with AED therapy, 32 with epilepsy but not receiving AEDs, and 34 controls were recruited. All subjects were aged 18-65 years. Blood (20 ml) was removed for hormone assays, after which each subject completed a validated questionnaire [Sexuality Experience Scores (Frenken and Vennix, 1981)] aimed at exploring the individuals' sexual activity and attitudes to sexual morality. RESULTS: Men taking carbamazepine (CBZ) only had significantly higher mean sex hormone-binding globulin (SHBG) levels than the control group. The CBZ group also had a significantly lower mean DHEAS concentration than the control, untreated, and sodium valproate (VPA) monotherapy groups. The phenytoin monotherapy group (PHT) had a significantly higher mean SHBG than both the control and untreated groups, and had a significantly higher mean total testosterone (TT) value than the control untreated, CBZ, and VPA groups, and a significantly lower mean DHEAS than the controls, untreated, and VPA groups. Men receiving more than one AED had significantly higher mean SHBG concentrations compared with control, untreated, and VPA groups. In addition, the polytherapy group's mean TT was significantly higher than the control and VPA groups, although its mean DHEAS concentration was lower than the control, untreated, and VPA groups. There were no significant differences between the study groups in mean FT, Budrostenedione (AND), or estradiol levels. But the CBZ, PHT, and polytherapy groups had significantly lower mean free and rogen index (FAI) than the controls. The CBZ group had a lower mean FAI than the VPA group. The polytherapy group had a lower FAI than the untreated group. Sexuality Experience Scores (SES) showed that those men receiving AEDs embraced a stricter sexual morality than the controls and untreated, and expressed greater satisfaction with their marriages than the control and untreated groups. CONCLUSIONS: Seizure type did not affect SES scores. Multiple regression showed men who had received further education were less accepting of strict sexual morality. PMID- 9952268 TI - Effects of menopause on seizures in women with epilepsy. AB - PURPOSE: Although important associations between epilepsy and women's hormonal phases are described, the relation of menopause to epilepsy has received little attention. METHODS: By using a structured interview, we studied menopausal women with epilepsy seen at the University of Maryland Epilepsy Center over a 1-year period from 1994 to 1995. We analyzed the characteristics and temporal relation of the seizures to menopause and compared the frequency and severity of the seizures with those in a similar group of premenopausal women. RESULTS: We identified 61 menopausal women (46 who were postmenopausal and 15 perimenopausal) and compared them with 46 premenopausal women. No statistically significant differences were noted in either the frequency or the severity of seizures comparing all menopausal or only postmenopausal with premenopausal women. However, 12 (20%) of the 61 menopausal women noted that their seizures first began during or after menopause, with eight having no proven cause for their seizures. Many individual women described changes in their seizures with menopause. Among the 61 menopausal women, 49 had established epilepsy before the onset of menopause, and 20 (41%) reported worsening of their seizures with menopause, 13 (27%) noted improvement, and 16 (33%) described no changes. These observations were similar for peri- and postmenopausal women. Of the 15 menopausal women taking hormone replacement therapy, the six taking progestin were significantly less likely to report worsening of their seizures. CONCLUSIONS: These findings support the view that hormonal influences are important in women with seizures. Although, in aggregate, menopausal (combined perimenopausal and postmenopausal) and postmenopausal women's seizures were similar in frequency and severity to those of other women, menopause was associated with changes in seizures for some women. Moreover, menopause may be a previously unrecognized factor for some new-onset seizures. The relations between menopause and epilepsy deserve to be more fully investigated. PMID- 9952269 TI - Components of attention in children with complex partial seizures with and without ADHD. AB - PURPOSE: To evaluate attentional difficulties in children with complex partial seizures, we reviewed the records of 12 children with complex partial seizures with attention deficient hyperactivity disorder (CPS/ADHD); 21 children with CPS without ADHD (CPS); 22 children with ADHD; and 15 control children. METHODS: Each child completed a computerized performance test (CPT), which evaluated sustained attention, inhibition of response, response time, and consistency of response. The ADHD groups also completed the CPT after a dose of methylphenidate. RESULTS: The results found poorest performance on the CPT by the CPS/ADHD group. Particular difficulty in attention was found for children with epilepsy regardless of the ADHD diagnosis. When methylphenidate was administered to the ADHD groups, both groups improved in performance on the CPT. CONCLUSIONS: Epilepsy may predispose children to attention problems that can significantly interfere with learning. Similar improvement for children with CPS/ADHD was found with methylphenidate compared with baseline as for children with ADHD but without CPS. PMID- 9952270 TI - Self-efficacy and social support as mediators in the relation between disease severity and quality of life in patients with epilepsy. AB - PURPOSE: This study examined the influence of two psychosocial variables mediating between disease severity and quality of life (QoL) in epilepsy; social support and mastery (measured by locus of control and self-efficacy). A model placing these two variables as mediators between disease severity and QoL was tested with structural equation modeling. METHODS: Eighty-nine patients with epilepsy (58% men, age 36+/-12 years) were given the following instruments: Liverpool Seizure Severity Scale, Interpersonal Support Evaluation List, Epileptic Self-Efficacy Scale, Locus of Control scale, and the World Health Organization's Quality of Life Questionnaire, the WHOQOL. RESULTS: Structural equation modeling showed good fit between the research model and the data (Bentler-Bonett Normalized Index of fit, 0.96; LISREL GFI, 0.95). Ninety percent of the variance of the WHOQOL was explained by a combination of disease severity, self-efficacy in epilepsy, social support, and locus of control. Mastery was found to mediate the correlation between disease severity and QoL, and social support was found to act as a mediator between disease severity and mastery. CONCLUSIONS: The study findings emphasize the possibility of improving QoL among patients with epilepsy by counseling and treatment aimed at reinforcing their self-efficacy and locus of control, as well as by improving their SoS. PMID- 9952271 TI - Referral patterns of family physicians may allow population-based incidence studies of childhood epilepsy. AB - PURPOSE: To evaluate the burden of illness of childhood epilepsy on patient, care giver, and society, representative incidence cohorts must be followed longitudinally. Case ascertainment through pediatricians and neurologists would be a valid method if family physicians refered all new cases of childhood epilepsy. The study objective was to determine whether family physicians' referral patterns in Southwestern Ontario make it possible to conduct a population-based incidence study of childhood epilepsy by sampling only from specialists' practices. METHODS: Of the 1,718 family physicians practicing in Southwestern Ontario, a systematic sample participated in a mailed survey. Case simulations describing seven types of childhood seizures were presented to physicians with instructions to respond as to whether they would investigate/manage without referral; refer to a specialist only if problems occurred; or refer to a specialist always. RESULTS: Of 214 family physicians, 185 (86.4%) returned completed surveys; 86% would not refer a child with a febrile seizure. Referral to a specialist would be made always by 93% of family physicians for patients with status epilepticus, 95% for worsening partial epilepsy, 82% for a first, brief, generalized clonic seizure, 80% for absence epilepsy, and 99% for neonatal seizures. Only 50% of family physicians would always refer a neurodevelopmentally abnormal child with generalized clonic epilepsy, but a further 37% would refer if problems occurred. CONCLUSIONS: It is feasible to recruit a representative population-based cohort of recently diagnosed patients for epidemiologic studies of childhood epilepsy by surveying pediatricians and neurologists. These survey results could be used to adjust estimates of incidence obtained through specialists' practices for the bias in case ascertainment that may result from this practical method. PMID- 9952273 TI - Epilepsy and religious experiences: Voodoo possession. AB - Epileptic seizures have a historical association with religion, primarily through the concept of spirit possession. Five cases where epileptic seizures were initially attributed to Voodoo spirit possession are presented. The attribution is discussed within the context of the Voodoo belief system. PMID- 9952272 TI - Family studies and human leukocyte antigen class II typing in Indian probands with seizures in association with single small enhancing computed tomography lesions. AB - PURPOSE: To define the clinical features of the syndrome of seizures associated with single, small, enhancing computed tomography (CT) lesions (SSELs) in 235 Indian probands and seizure types among their family members. Human leukocyte antigen (HLA) class II genomic typing in randomly selected 41 probands was done to identify the role of hereditary factors in this syndrome. METHODS: The seizure types among 235 probands, their clinical outcome, and seizures in their family members were studied. Family data were collected on relatives of 212 additional probands with neurologic diseases other than epilepsy. HLA class II antigens were studied by using polymerase chain reaction (PCR) amplified DNA and sequence specific oligonucleotide probe (PCR-SSOP) hybridization. RESULTS: The seizures in 86% were partial with or without generalization; 77% had fewer than five seizures before the first CT scan. Evanescent focal neurologic deficits after seizures were noted in 40%. Most patients (97%) were treated with a single antiepileptic drug (AED). Significant resolution of the CT scan lesion was noted within 6 months in 125 (53%) of 235 cases. Two thirds of patients had no seizures while taking a single AED, and an additional 18% had no seizures even after their AEDs were discontinued. Epilepsy among relatives of Indian probands having seizures in association with SSELs was more common as compared with relatives of probands with other neurologic diseases. A family history of seizures was noted in 21% probands, the ratio of affected first- to second-degree relatives was 4.3:1, and 60% of affected sibs had syndromic concordance with probands. There was a positive association of HLA-DRB1*13 (Pc = 0.036) with this syndrome. CONCLUSIONS: The syndrome of seizures in association with SSELs seems to be a benign localization-related epileptic syndrome. Our results of HLA studies point to an inherited susceptibility to an infective agent, which in most cases is of cysticercal etiology. PMID- 9952274 TI - Rasmussen's encephalitis with concomitant cortical dysplasia: the role of GluR3. AB - The role of the glutamate receptor GluR3 in Rasmussen's encephalitis is actively under investigation. Autoimmune processes with this receptor as the target are currently theorized. We provide an additional case of pathologically proved Rasmussen's encephalitis (with concomitant cortical dysplasia) in the presence of antibodies against the GluR3 receptor. PMID- 9952275 TI - Male monozygotic twins discordant for periventricular nodular heterotopia and epilepsy. AB - PURPOSE: To determine zygosity and study cerebral structure in apparently identical twins with discordant manifestation of focal epilepsy. METHODS: Male twins in their fifth decade were scanned by using magnetic resonance imaging (MRI) to detect structural abnormalities. Zygosity was determined by using 10 microsatellite markers. RESULTS: DNA analysis showed that the twins were >99.99% likely to be monozygous; they were discordant for bilateral symmetric periventricular nodular heterotopia (PNH) and epilepsy. CONCLUSIONS: The discordant occurrence of PNH and epilepsy in monozygotic male twins carries implications with respect to somatic mosaicism, currently held to be responsible for PNH in affected male subjects. PMID- 9952276 TI - Natural history and treatment of lupus nephritis. AB - Renal involvement occurs in the majority of patients with systemic lupus erythematosus. Contemporary therapeutic regimens for immunosuppression and for the treatment of hypertension, hyperlipidemia, infections, and seizures have likely contributed to improvements in the prognosis of these patients over the last four decades. Corticosteroids usually ameliorate the manifestations of lupus nephritis but achieve less complete and sustained remissions than do cytotoxic drugs. Among the cytotoxic drugs, pulse cyclophosphamide has one of the best profiles of efficacy and toxicity. Because each episode of exacerbation of lupus nephritis results in cumulative scarring, atrophy and fibrosis, we recommend continued maintenance treatment for 1 year beyond the point of complete remission of proliferative lupus nephritis. Studies are in progress to determine whether innovative treatment strategies will enhance efficacy and minimize toxicity associated with cytotoxic drug therapies. Lupus membranous nephropathy poses a lower risk of renal failure, but persistent nephrotic syndrome confers risks of cardiovascular events; this form of lupus nephritis is usually treated with less intensive regimens of corticosteroids, cytotoxic drugs, or cyclosporine. The prognosis and overall success of treatment for lupus nephritis seem to vary widely among geographically and racially diverse populations. The causes for the apparently worse prognosis and poorer responses to treatment of lupus nephritis in Black patients are currently unexplained and require further study. Until such data are available, caution is clearly warranted in extrapolating evidence, particularly about prognosis and effects of treatment, among different populations of patients with lupus nephritis. PMID- 9952277 TI - Relevance of systemic lupus erythematosus nephritis animal models to human disease. AB - Systemic lupus erythematosus (SLE) is characterized by spontaneous B and T cell autoreactivity and multiorgan immune injury including severe glomerulonephritis. This autoimmune syndrome results from a global derangement in immune regulation dependent on the interaction of complex genetic and environmental susceptibility factors. Animal models have provided a powerful tool to study disease mechanisms and novel therapeutic interventions under well-defined conditions, and bypass the barriers inherent in the study of human lupus. Classical models of spontaneous and investigator-induced murine lupus, their mutant variants, and novel transgenic and gene-targeted mutant lineages have been particularly useful. Extensive genome typing in inbred and recombinant lupus-prone strains permits mapping and characterization of multiple lupus susceptibility loci and genes and their contribution to various disease phenotypes. Murine models provide important insight into the identity of targeted self-antigens, the molecules and pathways that maintain tolerance, immune cell and cytokine interactions that promote autoimmunity, and mechanisms of renal localization and injury by immune effectors. These models reveal that multiple and independent mechanisms contribute to disease pathogenesis and provide a better understanding of the remarkable phenotypic and histopathologic heterogeneity that characterizes human SLE. PMID- 9952278 TI - Breakdown of self-tolerance and the pathogenesis of autoimmunity. AB - Autoimmunity results from a breakdown of physiological mechanisms responsible for maintaining tolerance to self-antigens. These mechanisms are traditionally divided into central and peripheral. T or B lymphocytes that bind to self antigens with high avidity are deleted or rendered unresponsive during their ontogeny in generative lymphoid organs such as the thymus and the bone marrow (central tolerance). However, this elimination process is incomplete, and regulatory mechanisms that keep mature autoreactive lymphocytes in check are necessary for preventing autoimmunity (peripheral tolerance). Peripheral tolerance mechanisms include passive or activation-induced T and B cell apoptosis, anergy, ignorance, and perhaps suppression of autoreactivity by regulatory lymphocytes. Observations in humans and experimental animals with defined genetic mutations provide examples of autoimmune disorders arising from failure to maintain peripheral tolerance to self. However, multiple factors are necessary for the induction of autoimmunity. For example, bacterial and viral infections may precipitate autoimmune disease in genetically susceptible individuals by exposing autoreactive T cells to cross-reactive peptides (molecular mimicry) or by enhancing lymphocyte stimulation. PMID- 9952279 TI - The role of apoptosis in autoimmunity: immunogen, antigen, and accelerant. AB - The immunologic basis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE) is complex and multifaceted. Recent advances in the field of apoptosis have suggested new paradigms for the development of autoimmunity. This review examines the role that apoptosis plays in maintaining immunologic tolerance to self-antigens, and how abnormalities in the regulation of apoptosis can lead to a breakdown in self-tolerance. This article also examines the increasing recognition of apoptotic cell antigens as the targets of autoantibodies and discusses the possibility that the autoimmune response characteristic of SLE is specifically directed against apoptotic cells. In addition, we will describe some of the features that distinguish nonpathogenic anti-DNA autoantibodies from those which deposit in the kidney and lead to lupus nephritis. Finally, we will attempt to synthesize the vast body of data connecting apoptosis and SLE into a single hypothesis in which we suggest that apoptotic cells are a primary source of immunogen, and that abnormalities in the handling of apoptotic cells can lead to a breakdown in self-tolerance. PMID- 9952280 TI - The role of autoantibodies in the pathogenesis of lupus nephritis. AB - Despite intensive research over the past three decades, the events leading to pathogenic autoantibody production and immune deposit formation in individuals with systemic lupus erythematosus continues to be debated. The controversy is fueled by the clinical observations that individual patients with lupus have variable expression of disease, and that it is often difficult to completely distinguish the events involved in the initiation of nephritis from the processes leading to progressive disease and organ failure. This review focuses on the mechanisms of immune deposition in individuals with lupus nephritis. Recent evidence derived from both analysis of spontaneously occurring animal models of lupus nephritis and human lupus nephritis suggests that direct binding of autoantibodies to glomerular antigens is an important mechanism in lupus and other immune complex nephritides. In situ deposition of circulating autoantigens and autoantibodies also may play a role. These findings, taken together with observations from analysis of other autoimmune diseases, suggest that autoantigen ligation by autoantibodies may contribute to the inflammatory/fibrogenic response through either direct stimulation of cells or interruption of cell-cell or cell matrix interactions. The nature of these type of interactions in individual patients therefore may have disease-modulating effects. For example, the predominant autoantibody response likely influences the glomerular response to immune deposition and the ensuing inflammation. The evidence for, and implications of, this hypothesis are discussed. PMID- 9952281 TI - Cytokines in the pathogenesis of systemic lupus erythematosus. AB - Cytokines, chemokines, and growth factors are overexpressed by renal parenchymal cells and by infiltrating mononuclear cells in human and experimental lupus nephritis. The importance of cytokines in the pathogenesis of lupus nephritis has been established using spontaneous mouse models of systemic lupus erythematosus (SLE). The actions of these cytokines are complex. There is a growing appreciation that the cytokine level and stage of kidney disease determines whether cytokine protects or promotes further tissue injury. This article identifies potential therapeutic targets and strategies that might halt progressive renal injury in patients with SLE. PMID- 9952282 TI - Lupus nephritis: novel immunosuppressive modalities and future directions. AB - Systemic lupus erythematosus (SLE) is a multisystemic disease characterized by alterations in the regulation of both cellular and humoral immune responses. B cell hyperactivity and genetic aberrations lead to formation of compliment-fixing IgG autoantibodies including anti-DNA and anti-nucleosome antibodies. Pathological T cell clones that recognize double-stranded DNA and nucleosomes further drive B cell production of DNA autoantibodies. Deposition of autoantibodies within the skin, kidney, brain, and other organ systems contributes to the pathophysiology and clinical manifestations of SLE. A growing body of experimental evidence indicates that DNA antibodies contribute to the histological changes observed in lupus nephritis. The binding of anti-DNA and other autoantibodies to basement membranes and other cellular structures within the glomerulus results in activation of compliment and recruitment of inflammatory cells into the glomerulus. The use of high-dose steroid hormones and cytotoxic agents have improved patient and renal survival, but are associated with major infection, infertility, osteoporosis, and secondary malignancies. New pharmacological approaches to the treatment of lupus nephritis will include drugs that deplete specific B cell clones involved in the synthesis of nephritogenic autoantibodies as well as the blocking of signal transduction pathways required for antigen-dependent antibody synthesis. Novel clonal-specific approaches to immunosuppression in patients with SLE offer the potential for precise targeting of the disease pathogenesis and for reducing toxic complications of treatment. PMID- 9952283 TI - Renal transplantation for end-stage renal disease caused by systemic lupus erythematosus nephritis. AB - The 1975 observations of the Advisory Committee of the Renal Transplant Registry about systemic lupus erythematosus (SLE) remain largely unaltered. The SLE patient's survival after renal transplantation has improved, but remains similar to the non-SLE transplantation population. Disease activity declines throughout the transplantation period with a low rate of graft loss due to recurrent disease. There is slight discordant evidence about spontaneous renal recovery and graft survival rates in the SLE transplant population. The latter difference may relate to variances in the donor source (live-related versus cadaveric). The original report did not address the now well-recognized immediate- and long-term risks posed by the anti-phospholipid antibody syndrome, the accelerated rate of vascular disease, hematologic malignancies, and corticosteroid osteoporosis in the SLE transplant recipient. PMID- 9952284 TI - Concentrations of leptin in the serum of pregnant, lactating, and cycling rats and of leptin messenger ribonucleic acid in rat placental tissue. AB - Leptin concentrations were measured in the serum of cycling, pregnant, and lactating Sprague-Dawley rats. Serum leptin concentrations did not vary significantly during the estrous cycle. In contrast, as gestation advanced, serum leptin concentrations increased significantly, p < 0.0001. Following delivery, leptin concentrations declined and remained stable during lactation. Leptin messenger ribonucleic acid (mRNA) was identified in the visceral adipose tissue and placenta of rats sacrificed on days 14 and 21 of pregnancy. The relative abundance of placental leptin mRNA increased approximately 4 to 5 fold from day 14 to 21 of gestation. The pattern of elevated leptin concentrations in the serum of late pregnant rats is similar to that reported in pregnant women, therefore the rat may be a useful model for the study of leptin during pregnancy. The increase in leptin in the serum of late pregnant rats, as well as an increase in placental mRNA, raises the possibility that leptin may serve a physiological role for the late parturient rat and/or its young. PMID- 9952285 TI - Growth inhibition of leukemic cells by (-)-epigallocatechin gallate, the main constituent of green tea. AB - In this report, we presented the results that EGCG, the main constituent of the polyphenols present in Japanese green tea inhibited growth of leukemic cell lines of both human and mice. The proliferation of human leukemic cell lines and mouse NFS60 cell line was inhibited by EGCG. Sensitivity of each line to EGCG was different, and more than 50% of DNA synthesis was reduced in all the cell lines in the presence of 50 microM EGCG. On the other hand, normal hematopoietic progenitor cells retained their natural function of supplying mature cells of various lineages in the presence of less than 10 microM EGCG in vitro. Even in the presence of 100 microM EGCG, half the colonies containing all the lineages of cells were developed. All the dead cells of each line showed characteristics of apoptosis, which might be due to inhibition by EGCG of growth factors' signaling. Besides anticarcinogenic activity, EGCG is expected to have a new function for leukemia therapy without side effects. PMID- 9952286 TI - Intralymphocyte free magnesium and calcium and insulin tolerance test in a group of essential hypertensive patients. AB - In order to assess the links which are claimed to exist between peripheral insulin resistance and intracellular magnesium and calcium concentrations, we measured free intralymphocyte magnesium (Mg(i)) and calcium (Ca(i)) concentrations as well as the rate constant of plasma glucose disappearance (K(itt)) after insulin injection (insulin tolerance test: ITT) in a group of 16 normotensive control subjects (NC) and 34 essential hypertensive subjects (EH). Mg(i) and Ca(i) were measured in triplicate by means of a fluorimetric technique based on the dyes furaptra and fura-2 respectively. K(itt) values proved significantly reduced in EH as compared to NC (M +/- SD, EH: 4.49 +/- 1.31 vs 5.28 +/- 1.19, P <0.05; 95% confidence limits: 0.23-1.5). Mg(i) and Ca(i) were not statistically different in EH as compared to NC subjects (Mg(i), NC: 266 +/- 20 micromol/l; EH: 245 +/- 50 micromol/l; Ca(i), NC: 47 +/- 9 nmol/l EH: 46 +/- 13 nmol/l). We found a statistically significant inverse correlation in the whole study group between K(itt) and body mass index (R= -0.363, P<0.01) and a statistically significant positive correlation between K(itt) and Mg(i) (R=0.347, P=0.013) was found. In a step-up multivariate regression analysis including blood pressure, plasma lipids, BMI, plasma magnesium, fasting insulin, fasting glucose, Mg(i) and Ca(i), the dependent variable K(itt) is statistically significantly correlated with body mass index and Mg(i). In a first attempt to study the relationships between insulin resistance, Mg(i) and Ca(i) in nucleated cells, the chosen index of peripheral resistance seems to be linked to intracellular free magnesium. PMID- 9952287 TI - Expression of lymphocyte subpopulations, cytokine serum levels and blood and urine trace elements in nickel sensitised women. AB - In this study, 20 non-allergic and 20 non-atopic women sensitised only to nickel (Ni) showed similar levels of urine and serum Ni and serum chromium (Cr). On the contrary, serum copper, a marker of inflammation, was significantly higher in the Ni-sensitised group. Sensitised women also had higher values of blood B CD19+, CD5--CD19+ and B and natural killer CD3--CD25+ lymphocytes, but not alterations of some other lymphocyte subsets and serum cytokines. Urine Ni was correlated with "memory" CD4+-CD45RO+ lymphocytes in the non-allergic women and with T CD4+ CD45RO+ and CD3+-CD25+ cells in the atopic women; these subjects also showed a statistically significant correlation of serum Ni with B CD5+-CD19+ lymphocytes and serum IL-13. Moreover, serum Cr of both groups of women was positively or negatively correlated with activated HLA-DR+ cells and/or serum IL-5 and interferon gamma. These results (confirming in part those of a previous study on non-allergic men) suggest that both Ni and Cr are involved in mechanisms regulating the immune response and that allergy to these metals could be considered an alteration of their physiological role. PMID- 9952288 TI - Peripheral type benzodiazepine receptor in T lymphocyte rich preparation. AB - Some types of mood disorders and drugs are suggested to affect peripheral type benzodiazepine receptors (PBR), but their mechanisms are unclear. The isolation of pure lymphocytes is requisite for the investigation of the function of PBR on lymphocytes, since platelets and monocytes also have many PBR. The objective of this study was to establish a method of binding assay for PBR using pure T lymphocytes. Mononuclear cells and T lymphocytes were prepared by using a density gradient material and magnetic beads, respectively. The cells were analyzed using flow cytometry and a counting chamber. Binding studies were performed using T lymphocytes from 10 normal volunteers. The T lymphocytes were incubated with [3H]PK11195, harvested on glass fiber filters, and counted with a plate scintillation counter. The binding data were analyzed by the Scatchard method. With the magnetic bead technique, pure T cells were selected that contained only 1.5% monocytes and platelet/cell ratio of 1.4. The Scatchard plot of the data indicated that only one type of specific binding site was involved in the binding. The dissociation constant (Kd) was 3.8+/-1.3nM (mean+/-SD), and the Bmax was 379+/-124 fmol//10(6) cells (mean+/-SD). The density gradient- magnetic beads technique can be used as an appropriate method of preparation of T cells for PBR binding assay. PMID- 9952289 TI - Excitatory mechanism of veratridine on slowly adapting pulmonary stretch receptors in anesthetized rabbits. AB - The excitatory effects of veratridine on slowly adapting pulmonary stretch receptors (SARs) were studied before and after administration of ouabain (a Na+ K+ ATPase inhibitor) in anesthetized, artificially ventilated rabbits after vagus nerve section. Administration of veratridine (40 microg/kg) stimulated SAR activity but did not significantly alter tracheal pressure. Administration of ouabain (50 microg/kg) initially stimulated SAR activity during both inflation and deflation, but after 20 min, two different types of SAR responses were observed; one became silent at the peak, of inflation only, and the other maintained excitatory activity during both inflation and deflation phases. Veratridine usually inhibited SAR activity in ouabain-treated animals, irrespective of the difference of ouabain effects. These results suggest that veratridine-induced stimulation of SARs is closely related to the change in the Na+ ion gradient, which is regulated by Na+ pump activity. PMID- 9952290 TI - Cardiac effects of benzodiazepine receptor agonists and antagonists in the isolated rat heart: a comparative study. AB - Effects of PK 11195 and flumazenil on cardiac responses to diazepam, clonazepam and zolpidem were compared. Coronary flow rate was increased at relatively low doses of diazepam and decreased at higher doses. Clonazepam induced a dose dependent increase, and zolpidem a decrease of coronary flow rate. PK 11195 reduced the diazepam-induced increase of coronary flow rate, and flumazenil was ineffective. Neither antagonist evoked substantial changes in the decrease of coronary flow rate. PK 11195, and less so flumazenil, antagonized the clonazepam induced increase. PK 11195 and flumazenil only in their highest doses suppressed and respectively potentiated the zolpidem-induced decrease. Inotropy showed a biphasic response in the presence of diazepam, i.e. an initial transient decrease, followed by a dose-dependent increase in two steps. Clonazepam induced a similar response. Zolpidem increased the inotropy. The negative inotropic response induced by diazepam did not change significantly in the presence of PK 11195 or flumazenil. The positive inotropic response was suppressed by PK 11195, and less so by flumazenil. The negative response to clonazepam was antagonized by both PK 11195 and flumazenil; the positive response was not significantly changed. In the presence of lower doses of PK 11195, the zolpidem-induced response was potentiated, whereas higher doses produced reversal; flumazenil potentiated the response. In conclusion, the results support earlier suggestions, involving receptor mechanisms with cardiac effects of benzodiazepines. Both agonists and antagonists (inter)act in a different manner, suggesting that rather ambiguous receptor mechanisms are involved in benzodiazepine effects in the heart. PMID- 9952291 TI - Effects of butylated hydroxytoluene (BHT) enriched diet on serum antioxidant activity in pre-and overtly diabetic nod mice. AB - Preventive (antioxidant activity) and chain-breaking (total peroxyl radical trapping parameter) antioxidants in the serum of controls and butylated hydroxytoluene (BHT)-diet enriched nonobese diabetic (NOD) and C57B16/J mice from 5 to 25 weeks of age are measured in this study. A significant decrease in the overall potency of both antioxidant types is demonstrated in NOD untreated controls but not in animals whose diet was BHT-enriched. Therefore, we show that alterations of the antioxidant status in NOD mice is efficaciously counteracted by BHT. PMID- 9952292 TI - Enterostatin (Val-Pro-Asp-Pro-Arg)-like immunoreactivity in rat urine: relationship to corticosterone output. AB - Numerous studies have documented a role for enterostatins in appetitive behavior. However, due to the lack of knowledge about the distribution of enterostatins in tissues and body fluids, it has not been possible to examine the role of endogenous enterostatin in this process. To this end, using a polyclonal antibody raised against enterostatin -- Val-Pro-Asp-Pro-Arg (VPDPR), we examined the nature and distribution of enterostatin-like immunoreactivity in the rat urine by ELISA and chromatography. The results reported here show for the first time the presence of VPDPR-like immunoreactivity (VPDPR-LI) in rat urine. Further characterization of rat urine VPDPR-LI revealed that it is not due to VPDPR but to another peptide similar to VPDPR. Furthermore, as urinary excretion of corticosterone increases, the level of VPDPR-LI in urine decreases. PMID- 9952293 TI - Reactivity of homocysteine-thiolactone and alpha-methylhomocysteine-thiolactone with e-(aq) and OH-radical: a pulse radiolysis study. AB - The efficient radiation protecting agents homocysteine-thiolactone x HCl (HCTL x HCl) and its alpha-alkylated derivative (alpha-methyl-homocysteine, alpha-MHCTL x HCl) have been investigated in respect to the identification of the primarily formed species after absorption of ionizing radiation using pulse radiolysis technique.The reaction of e-(aq) with the unprotonated form of HCTL (k = 2.1 x 10(9) dm3 mol(-1) s(-1)) is leading to the formation of a radical anion having two absorption bands: at 275 nm (epsilon = 2500 dm3 mol(-1) cm(-1)) and 510 nm (epsilon = 930 dm3 mol(-1) cm(-1)), which decay with 2k = 2.3 x 10(9) dm3 mol(-1) s(-1). The protonated form of HCTL reacts with e-(aq) with k = 4.0 x 10(10) dm3 mol(-1) s(-1). The OH-radicals react with HCTL with k = 1.95 x 10(9) dm 3 mol(-1) x s(-1) resulting in a transient spectrum with lambda(max) = 265 nm (epsilon =2000 dm3 mol(-1) cm(-1)). The transients disappear with 2k = 2.1 x 10(9) dm3 mol(-1) s(-1). The reactivity of e-(aq) with alpha-MHCTL was determined for both forms: for the protonated, k = 1.25 x 10(10) dm3 mol(-1) s(-1) and for the unprotonated, k = 2.6 x 10(9) dm3 mol(-1) s(-1). The transient absorption spectrum at pH = 8.4 shows two absorption bands: lambda = 275 nm (epsilon = 3500 dm3 x mol(-1) x cm(-1)) and 490 nm (epsilon = 1160 dm3 x mol(-1) x cm(-1)). The transients disappear with 2k = 2.2 x 10(9) dm3 x mol(-1) x s(-1). The reaction of OH with alpha-MHCTL x HCl,k = 8.4 x 10(9) dm3 x mol(-1) x s(-1) (pH = 8.6) is resulting in an absorption spectrum with lambda(max) < 260 nm and an absorption band at 350 nm (epsilon = 510 dm3 x mol(-1) x cm(-1)). Up to 50 micros after pulse the transients decay with 2k = 5.5 x 10(9) dm3 x mol(-1) x s(-1) and thereafter by a k = 8.4 x 10(9) dm3 x mol(-1) x s(-1) (pH = 8.6) is resulting in an absorption spectrum with lambda(max) < 260 nm and an absorption band at 350 nm (epsilon = 510 dm3 x mol(-1) x cm(-1)). Up to 50 micros after pulse the transients decay with 2k = 5.5 x 10(9) dm3 x mol(-1) x s(-1) and thereafter by a first order reaction. In addition, the formation of some products was also studied. The yield of ammonia resulting from alpha-MHCTL x HCl strongly depends on pH, e.g. at pH = 5.1 Gi (NH3) = 0.95, whereas at pH = 9.15 it increases to Gi = 3.1. Hydrogen sulphide is formed in airfree solutions, Gi (H2S) = 0.29, whereas in the presence of N2O it is reduced to Gi (H2S) = 0.10. Some probable reaction mechanisms are presented. PMID- 9952294 TI - Effects of stress on amino acids and related compounds in various tissues of fasted rats. AB - The purpose of this study was to examine the effect of stress on the free amino acid pattern of plasma and various organs. Two groups of rats were deprived of food, for 24 hrs. One group was sacrificed after this time (fasting control representing mostly free endogenous amino acids) and the second group was first restrained in wire cages for 120 min before being sacrificed (fasting stress representing mostly the effects of stress on endogenous free amino acids). A third group had free access to food and was sacrificed at the same time (fed control representing mostly free amino acids absorbed from the gut and endogenous free amino acid metabolism). Fasting (as compared to fed controls) reduced alanine and arginine but increased ethanolamine, glutamic acid and glutamine in the plasma; increased ethanolamine, phosphoethanolamine and glutamic acid in the liver; increased carnosine, glutamic acid, phosphoethanolamine and glutamine in the ventricle; increased oxidized glutathione in the aorta; decreased alanine, aspartic acid, glutamic acid, leucine and methionine and increased glutamine in the pancreas; and decreased arginine in skeletal muscle. Fasting plus stress (as compared to fasting controls) reduced alanine and glutamine in the plasma; increased methionine in the liver; increased ethanolamine, GABA, and glutamic acid in the aorta; reduced arginine, glutamic acid, glutamine, leucine and methionine but increased ethanolamine in the ventricle; reduced ammonia and ethanolamine but increased histidine, isoleucine, leucine, lysine, phenylalanine, tyrosine and valine in the pancreas; and reduced ammonia in skeletal muscle. Fasting plus stress affects the amino acid composition of plasma and various of tissues but effects seen were individually different and strongly substance and tissue specific. Plasma changes did not coincide with tissue changes. Changes in the endogenous pattern of amino acids and related compounds in response to stress could be first indications of stress induced organ pathology. PMID- 9952295 TI - Risks for radiation-induced breast cancer: the debate continues. PMID- 9952296 TI - The radiation-induced S-phase checkpoint is independent of CDKN1A. AB - We recently demonstrated that, in response to radiation, replication is down regulated at the level of individual origins throughout S phase of the cell cycle. Since several in vitro studies demonstrate that CDKN1A (formerly known as p21) down-regulates replication by inhibiting PCNA, and since CDKN1A can retard progression of cells through S phase in vivo, the question arises whether CDKN1A is involved in the S-phase damage-sensing pathway. In the present study we analyzed the effect of ionizing radiation on CDKN1A+/+ and CDKN1A-/- cells derived from the HCT 116 cell line. Neither progression of cells through S phase nor survival after exposure to ionizing radiation is influenced by CDKN1A status in either synchronous or asynchronous cells. These results establish that CDKN1A is not necessary for the acute S-phase damage-sensing pathway that functions to prevent firing of replication origins during S phase. PMID- 9952297 TI - Increased hydroxyl radical production and apoptosis in PC12 neuron cells expressing the gain-of-function mutant G93A SOD1 gene. AB - Mutations of the SOD1 gene (formerly known as Cu,Zn-SOD) are frequently associated with the familial form of amyotrophic lateral sclerosis (ALS). The G93A mutation of SOD1 with substitution of Gly to Ala at residue 93 results in gain of a peroxidative function. Here we report that transfection of PC12 neuron precursor cells with the G93A mutation of SOD1 results in increased production of hydroxyl radicals (*OH) and an enhanced rate of cell death by apoptosis. Notably, PC12 cells transfected with the H63C/G93A mutant of SOD1 with a mutation in the catalytic site that converts histidine at position 63 to cysteine showed a dramatically reduced production of *OH and rate of death by apoptosis. Thus the gain of function of the mutant G93A SOD1 can be reduced by an active site mutation. These results provide additional genetic evidence for the hypothesis that the increased *OH production and induced cytotoxicity in neuron cells expressing the mutant G93A SOD1 results from the gain of peroxidative function by the enzyme's catalytic site. PMID- 9952298 TI - Low frequency of Ras gene mutation in spontaneous and gamma-ray-induced thymic lymphomas of scid mice. AB - Scid mice, which have a defect in the capacity to repair DNA double-strand breaks, were highly prone to the induction of thymic lymphomas after exposure to ionizing radiation; approximately 70% of mice developed lymphomas within 1 year after exposure to 1-3 Gy, whereas approximately 20% of unirradiated control mice developed lymphomas. To gain information on the possible role of Ras activation in development of thymic lymphomas in scid mice, we have examined both the frequency and the spectrum of Kras and Nras mutations in spontaneous and radiation-induced lymphomas. Neither activated Kras nor Nras genes were detected in spontaneous lymphomas, while Kras mutations increased in a dose-dependent manner in radiation-induced lymphomas. However, Kras mutations were infrequent (6% in lymphomas in mice exposed to 1 Gy, 12.5% in those exposed to 2 Gy, 16.7% in those exposed to 3 Gy), and no mutations were detected in Nras genes, suggesting that Ras mutation was not significantly involved in the development of thymic lymphomas in scid mice. Analysis of the spectrum of Kras mutations demonstrated unique mutations in both codons 13 (GGC to GAC) and 61 (CAA to CTA) in addition to the commonly identified substitution of GAT for GGT in codon 12 of Kras. PMID- 9952299 TI - Radiation-induced progressive decrease in fluid secretion in rat submandibular glands is related to decreased acinar volume and not impaired calcium signaling. AB - The mechanism(s) of radiation-induced salivary gland dysfunction is poorly understood. In the present study, we have assessed the secretory function (muscarinic agonist-stimulated saliva flow, intracellular calcium mobilization, Na+/K+/2Cl- cotransport activity) in rat submandibular glands 12 months postirradiation (single dose, 10 Gy). The morphological status of glands from control and irradiated rats was also determined. Pilocarpine-stimulated salivary flow was decreased by 67% at 12 months (but not at 3 months) after irradiation. This was associated with a 47% decrease in the wet weight of the irradiated glands. Histological and morphometric analysis demonstrated that acinar cells were smaller and occupied relatively less volume and convoluted granular tubules were smaller but occupied the same relative volume, while intercalated and striated ducts maintained their size but occupied a greater relative volume in submandibular glands from irradiated compared to control animals. In addition, no inflammation or fibrosis was observed in the irradiated tissues. Carbachol- or thapsigargin-stimulated mobilization of Ca2+ was similar in dispersed submandibular gland cells from control and irradiated animals. Further, [Ca2+]i imaging of individual ducts and acini from control and irradiated groups showed, for the first time, that mobilization of Ca2+ in either cell type was not altered by the radiation treatment. The carbachol-stimulated, bumetanide-sensitive component of the Na+/K+/ 2Cl- cotransport activity was also similar in submandibular gland cells from control and irradiated animals. These data demonstrate that a single dose of gamma radiation induces a progressive loss of submandibular gland tissue and function. This loss of salivary flow is not due to chronic inflammation or fibrosis of the gland or an alteration in the neurotransmitter signaling mechanism in the acinar or ductal cells. The radiation induced decrease in fluid secretion appears to be related to a change in either the water-handling capacity of the acini or the number of acinar cells in the gland. PMID- 9952302 TI - Halogen anion formation in 5-halouracil films: X rays compared to subionization electrons. AB - The radiosensitization properties of 5-halouracils (5-FU, 5-BrU and 5-IU), i.e. the enhanced sensitivity of biological media containing these compounds to ionizing radiation, have been studied using surface science methods. We show that soft X rays and near 0 eV electrons both induce dissociation of 5-halouracils into a halogen anion and a uracilyl radical. The yield of anions from 5-FU is much smaller than that from the bromo- and iodo-analogs. We explain the high anion yields in 5-BrU and 5-IU with dissociative electron attachment (DEA) of near 0 eV electrons. The thermodynamic threshold for DEA to 5-FU is near 2 eV and therefore prohibits dissociation by near 0 eV electrons. PMID- 9952301 TI - Comparison of strand breaks in plasmid DNA after positional changes of Auger electron-emitting iodine-125. AB - To elucidate the kinetics of the induction of DNA strand breaks by low-energy Auger electron emitters, we compared the yields of DNA breaks in supercoiled pUC19 DNA after the decay of 125I (1) in proximity to DNA after minor-groove binding (125I-iodoHoechst 33342, 125IH) and (2) at a distance from DNA (125I iodoantipyrine, 125IAP). Iodine-125 bound to the minor groove in DNA or free in solution is equally effective per decay in producing single-strand breaks (SSBs), while 125I bound to the minor groove is 6.7-fold more efficient than 125I free in solution in producing double-strand breaks (DSBs) (1.08 +/- 0.13 compared to 0.16 +/- 0.01 DSB/decay). Consequently, SSB to DSB ratios for 125IAP and gamma radiation (20.7 +/- 2.9 and 43.8 +/- 1.5, respectively) are greater than that for 125IH (2.9 +/- 0.4). Finally, the decay of 125IH leads to fragmentation of plasmid DNA beyond SSBs and DSBs. PMID- 9952300 TI - Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA dependent protein kinase-mediated rejoining of double-strand breaks. AB - Wortmannin has been shown to be an efficient radiosensitizer. Since wortmannin is able to inhibit DNA-dependent protein kinase (DNA-PK) and double-strand break (DSB) rejoining, it is believed that its mechanism of radiation sensitization is through the inhibition of DNA-PK-mediated repair of DSBs. However, since wortmannin is not a specific inhibitor, the possibility that other kinases are inhibited and thereby may contribute to radiosensitization cannot be ruled out. Here we present data confirming the radiosensitizing effect of wortmannin on cells of different cell lines. In the same range of wortmannin concentrations, survival after exposure to ionizing radiation correlated well with DSB rejoining and the induction of micronuclei, suggesting that the inhibition of the processing of DSBs is involved in the sensitizing effect. Pretreatment with wortmannin enhanced the radiosensitivity of ataxia telangiectasia (AT) cells, thereby precluding the participation of ATM protein in the radiation sensitization by wortmannin. At the same time, irradiated DNA-PK-deficient cells were not significantly affected by pretreatment with wortmannin. These observations support a likely mechanism; that is, wortmannin sensitizes cells to radiation through inhibition of the DNA-PK-mediated rejoining of DSBs. PMID- 9952303 TI - Radiation-induced DNA damage in tumors and normal tissues: V. Influence of pH and nutrient depletion on the formation of DNA-protein crosslinks in irradiated partially and fully hypoxic tumor cells. AB - It has been demonstrated that the yield of radiation-induced DNA strand breaks and DNA-protein crosslinks (DPCs) appears to depend predominantly on the oxygen concentration in the microenvironment around the DNA of mammalian cells (Radiat. Res. 142, 163-168, 1995). Consequently, these DNA lesions have the potential to be used to detect hypoxic cells or estimate the hypoxic fraction of solid tumors. Although it has been demonstrated that physiological factors (e.g. pH, temperature, nutrient depletion, etc.) have no influence on the induction and repair of both DNA strand breaks and DPCs in irradiated oxygenated cells (Radiat. Res. 140, 321-326, 1994), there are no data to suggest how these physiological factors influence the induction and repair of DNA strand breaks and DPCs in irradiated partially hypoxic or fully hypoxic cells. In the present study, the influence of pH (6.6-7.3) and nutrient depletion on the formation and/or repair of radiation-induced DNA strand breaks and DPCs in partially hypoxic (O2 concentration in the gas phase of 2.0-8.0%) or fully hypoxic (O2 concentration in the gas phase of 0.3-0.4%) populations of exponential (day 3) and plateau-phase (day 5) 9L rat brain tumor cells in culture was determined. Each population of cells was irradiated at 37 degrees C with 15 Gy and trypsinized at 4 degrees C after one half-time of strand break repair at 37 degrees C, and the DNA damage was measured using our alkaline elution technique, with or without proteinase K (PK) in the lysis solution. An analysis of the DNA-protein crosslink factor as a function of the oxygen concentration and a statistical comparison of the single strand scission factor measured at eluted fraction 7 (SSSF7), with or without PK in the lysis solution, indicate that pH and nutrient depletion do not significantly influence the formation and/or repair of DNA strand breaks and DPCs in irradiated partially hypoxic or fully hypoxic 9L cells. The data also demonstrate that the DNA lesions produced in irradiated partially hypoxic cells will cause the hypoxic fraction or fractional hypoxic volume to be overestimated by this DNA damage assay, not underestimated. However, this potential overestimation of the hypoxic fraction or fractional hypoxic volume should not limit the usefulness of this DNA damage assay in most laboratory studies, because it will take the contribution of a large cohort of partially hypoxic cells to overcome the dominance of the signal from a relatively small cohort of fully hypoxic cells. PMID- 9952304 TI - Induction of intracellular calcium oscillations in human skin fibroblast populations by sinusoidal extremely low-frequency magnetic fields (20 Hz, 8 mT) is dependent on the differentiation state of the single cell. AB - Experiments were performed to analyze whether short-term exposure to a sinusoidal extremely low-frequency electromagnetic field (20 Hz, 8 mT) can alter the dynamics of intracellular calcium in diploid human skin fibroblasts. In heterogeneous fibroblast populations, about 30% of the cells responded with a change in the oscillation activity of intracellular calcium within 40 min. It was demonstrated at the level of the single cell that the responsiveness of fibroblast populations to extremely low-frequency electromagnetic fields depends on the specific differentiation state of the exposed cell. The data obtained clearly indicate that mitotic progenitor fibroblasts respond with an enhancement of the dynamics of calcium, whereas in postmitotic fibrocytes a reduction of the dynamics was observed when the cells were co-stimulated with suboptimal concentrations of platelet-derived growth factor. Thus data from our laboratory on terminal differentiation induced by extremely low-frequency electromagnetic fields may be correlated with changes in the dynamics of Ca2+ reported here. PMID- 9952305 TI - Increased DNA synthesis in INIT/10T1/2 cells after exposure to a 60 Hz magnetic field: a magnetic-field or a thermal effect? AB - This study was designed to test the hypothesis that a 0.1-0.8-mT 60 Hz magnetic field may act as a promoter of carcinogenesis. C3H 10T1/2 mouse fibroblasts initiated with the carcinogen methylcholanthrene (INIT/10T1/2 cells) were used; in these cells, expression of the carcinogenic phenotype is suppressed indefinitely by the presence of retinyl acetate in the culture medium. After withdrawal of retinyl acetate, expression of the carcinogenic phenotype may be observed as the loss of contact inhibition. Cells grown without retinyl acetate were exposed to 0.1-0.8-mT (rms) 60 Hz magnetic fields or to sham fields. Eight days after exposure, magnetic-field and sham-exposed cells showed the same levels of incorporation of [3H]thymidine, and both had counts significantly higher than those of unexposed cells. The rate of incorporation of [3H]thymidine was very sensitive to small (0.1-0.8 degrees C) and transient (60 min) increases in incubation temperature during the first few days of withdrawal of retinyl acetate. Exposure of Jurkat (human acute T-cell lymphoma) and GH3 (rat pituitary tumor) cells to magnetic fields and sham conditions yielded similar results. INIT/10T1/2 cells cultured in the presence of retinyl acetate showed no effect of exposure conditions. Both magnetic-field and sham exposures caused a slight increase in temperature within the exposure zone in the incubator. Thus the differences between rates of incorporation of [3H]thymidine in magnetic field exposed, sham-exposed and unexposed cells seem to be attributable at least in part to a slight elevation in temperature during exposure. Since some cells appear to be extremely sensitive to small increases in temperature, measurements of magnetic-field effects must be made and interpreted with caution. PMID- 9952306 TI - Two-step model for the risk of fatal and incidental lung tumors in rats exposed to radon. AB - Data from 4276 rats with radon exposures up to 10,000 WLM at rates up to 1000 WL are analyzed with a two-step clonal expansion model. The age dependences of the hazard for the risks for fatal and for incidental tumors are very different. Therefore, two different parameterizations of the model are used in the two cases. In both cases radiation acts only on the initiating mutation and the clonal expansion, but not on the second mutation. Average exposure rates of 5 WL for fatal tumors and 0.5 WL for incidental tumors double the rate of spontaneous mutations. While the fatal tumors show a linear increase in the effective clonal expansion rate up to about 100 WL average exposure rate and a saturation at higher exposure rates, the incidental tumors follow a step-like behavior of this parameter. It is proposed that only the fatal lung tumors among the rats be used for generalizations to models for lung cancer in humans. The fitted model for fatal tumors shows an inverse dose-rate effect at average exposure rates above 20 WL. However, below 10 WL the lung cancer risk per unit exposure decreases with increasing duration of exposure. Between 10 and 20 WL, the difference in ERR/WLM between acute and protracted exposure is small. PMID- 9952307 TI - Comparison of breast cancer incidence in the Massachusetts tuberculosis fluoroscopy cohort and in the Japanese atomic bomb survivors. AB - Breast cancer has occurred in excess among women exposed briefly to atomic bomb radiation and among those exposed repeatedly over many years to medical radiation for tuberculosis (TB). The excess relative risk of breast cancer incidence in the Japanese atomic bomb survivors, however, is significantly higher (two-sided P = 0.04) than that in the Massachusetts TB fluoroscopy patients. The best estimate of the ratio between the excess relative risk coefficients for the Japanese and Massachusetts cohorts is 2.11 (95% CI 1.05, 4.95). However, this higher relative excess risk is attributable to the lower baseline risk of breast cancer among Japanese women compared with the Massachusetts women, and the excess absolute breast cancer risks in the two data sets are statistically indistinguishable (two sided P = 0.32). The best estimate of the ratio between the excess absolute risk coefficients among Japanese and Massachusetts women is 0.73 (95% CI 0.41, 1.44). After childhood exposures, an early onset of radiation-induced breast cancer was seen among Japanese atomic bomb survivors but not among the Massachusetts women. There are some indications (two-sided P = 0.04) of differences in the patterns of risk over time since exposure between these groups exposed in childhood. However, in general there are no marked differences between the Massachusetts and Japanese data sets in the age and time distribution of risk of radiation-induced breast cancer. These data provide little evidence for a reduction of breast cancer risk after fractionated irradiation. PMID- 9952308 TI - Does fractionation decrease the risk of breast cancer induced by low-LET radiation? AB - Whether fractionation decreases the risk of breast cancer induced by low-LET radiation is a question of some importance. Analyses of the data for TB cohorts who were exposed to multiple fluoroscopies show an apparently similar breast cancer risk compared with those for the acutely exposed A-bomb survivors. However, the fluoroscopy cohorts were subjected to very much lower-energy photons (60-80 kVp) compared with the A-bomb survivors; the increased RBE associated with the low photon energies to which these fluoroscopy cohorts were exposed suggests that, in comparison to the risk estimates for the A-bomb survivors, the risk estimates from the X-ray fluoroscopy cohorts are increased because of the lower energy X rays and decreased by a similar amount due to fractionation, resulting in an overall apparent equality of risk. Thus the results from the most powerful epidemiological data sets available for assessing breast cancer risks after fractionated exposure to low-LET radiation (the fluoroscopy cohorts) are quite consistent with a lower radiation risk for a fractionated exposure in comparison to an acute exposure. In general, for any cancer site, estimates of the dose-rate effectiveness factor (DDREF) generated by comparing the results for A-bomb survivors with those for the TB fluoroscopy cohorts should probably be roughly doubled from their apparent values because of the increased RBE of the fluoroscopy X rays. PMID- 9952309 TI - Chemokine receptors--future therapeutic targets for HIV? AB - To date, triple drug therapies for HIV have resulted in spectacular reductions in the number of virus particles and often remarkable recovery from disease in infected people. There is still, however, a great need for improved therapies. A battery of drugs aimed at different stages in the life cycle of HIV will enable switching of treatments if resistant viruses emerge or if patients are unable to tolerate particular therapies. Intense efforts are now underway to produce drugs that target chemokine receptors used by HIV to gain entry into cells. HIV needs two receptors on the host cell surface for efficient attachment and infection. HIV first interacts with CD4 but requires a coreceptor to penetrate the cell membrane. The first coreceptor, identified in 1996, is a member of the family of chemokine receptors, members of the G-protein coupled 7TM superfamily, which are involved in the trafficking of leukocytes in immune surveillance and inflammation. Such a therapeutic approach would differ from those used successfully to date, which focus largely on proteins coded by the HIV virus itself, and which are required for the replicative cycle of the virus. Many small, orally bioavailable molecules that block various 7TM receptors are used to treat a panoply of diseases including ulcers, allergies, migraines, and schizophrenia. These molecules are the cornerstone of the pharmaceutical industry's contribution to the fight against so many diseases, and it is hoped that a small molecule inhibitor of coreceptors can be developed that will become an invaluable drug in the fight against AIDS. PMID- 9952310 TI - Integrated cytochrome P450 reaction phenotyping: attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes. AB - With the increased availability of human liver tissue, recombinant (cDNA expressed) cytochrome P450 proteins (rCYPs), and knowledge of the human CYP pool (e.g. immunoquantitated levels of each CYP form in native liver microsomes), it is now possible to carry out in vitro "CYP reaction phenotyping" in an integrated manner. Reaction phenotyping allows one to identify which CYP form(s) is (are) involved in the metabolism of a given drug, using a combination of data obtained with native human liver microsomes and rCYP proteins. The following describes how one can attempt to integrate such data. A total of ten drugs are included in the analysis, represented by twelve reactions (six hydroxylations, two O demethylations, one N-demethylation, one O-deethylation, and two sulfoxidations) that are largely catalyzed (> or =20%) by various combinations of CYPs (CYP3A4, CYP2C9, CYP1A2, and CYP2D6), and characterized by a wide range of apparent Km values (12-820 microM). Briefly, reaction rates measured with individual rCYPs are normalized with respect to the nominal specific content of the corresponding CYP in native human liver microsomes. In turn, the normalized rates for each rCYP are summed, yielding a "total normalized rate" (TNR), and the normalized rate for each rCYP is expressed as a percent of the TNR (% TNR). Finally, % TNR is related to inhibition (percent inhibition in the presence of CYP form selective chemical inhibitors; % I) and univariate regression analysis (r > or = 0.63; P < or = 0.05; N > or = 10 different livers) data obtained with native human liver microsomes. Therefore, the reaction phenotype of a drug is assigned by integrating all three data sets (r, % TNR, and % I). PMID- 9952311 TI - Structural and functional impairment of mitochondria in adriamycin-induced cardiomyopathy in mice: suppression of cytochrome c oxidase II gene expression. AB - The use of adriamycin (ADR) in cancer chemotherapy has been limited due to its cumulative cardiovascular toxicity. Earlier observations that ADR interacts with mitochondrial cytochrome c oxidase (COX) and suppresses its enzyme activity led us to investigate ADR's action on the cardiovascular functions and heart mitochondrial morphology in Balb-c mice i.p. treated with ADR for several weeks. At various times during treatment, the animals were assessed for cardiovascular functions by electrocardiography and for heart tissue damage by electron microscopy. In parallel, total RNA was extracted from samples of dissected heart and analyzed by Northern blot hybridization to determine the steady-state level of three RNA transcripts encoded by the COXII, COXIII, and COXIV genes. Similarly, samples obtained from the liver of the same animals were analyzed for comparative studies. Our results indicated that 1) treatment of mice with ADR caused cardiovascular arrhythmias characterized by bradycardia, extension of ventricular depolarization time (tQRS), and failure of QRS at high concentrations (10-14 mg/kg body weight cumulative dose); 2) the heart mitochondria underwent swelling, fusion, dissolution, and/or disruption of mitochondrial cristae after several weeks of treatment. Such abnormalities were not observed in the mitochondria of liver tissue; and 3) among the three genes of COX enzyme examined, only COXII gene expression was suppressed by ADR treatment, mainly after 8 weeks in both heart and liver. Knowing that heart mitochondria represent almost 40% of heart muscle by weight, we conclude that the deteriorating effects of ADR on cardiovascular function involve mitochondrial structural and functional impairment. PMID- 9952312 TI - Identification of a novel complement-dependent serum-elicited inward current in the Xenopus oocyte provoking Ca2+ influx and subsequent activation of Cl- channels. AB - The membrane spanning complement channel is assumed to be a nonselective ion 'pore', although little evidence is available to support this hypothesis. In this paper we provide evidence that Ca2+ entry and Cl- exit occur rapidly after complement activation and precede the development of a long-lasting complement dependent inward current. Addition of rabbit serum (a source of heterologous complement) and mouse anti-human insulin receptor antibody to a single Xenopus oocyte expressing human insulin receptor was shown to stimulate an initial hyperpolarising current followed by a sustained depolarising current. On voltage clamping the oocyte, a novel long-lasting inward current generated by serum addition was detected. Complement classical pathway-stimulated calcium influx into the oocyte was directly demonstrated using 45Ca influx measurements. In addition, we found that Ca2+ influx was required for the stimulation of the complement alternative pathway-dependent inward current. The novel conductance elicited by the classical pathway was outwardly rectifying, had a reversal potential of -35 +/- 8 mV (or -52 +/- 7 mV in the presence of chloride channel inhibitors), was inhibited by nifedipine, and was observed in the presence but not in the absence of the pore-forming complement component C9. As overactivation of complement does play a role in many inflammatory or autoimmune diseases, inhibition of early complement-mediated ion flux might restrict tissue damage and aid recovery from such diseases. PMID- 9952313 TI - Influence of the antiallergic drug oxatomide and derivatives on membrane structures: relation with inhibition of calcium influx in rat basophilic leukemia cells. AB - Oxatomide is an H1 antihistaminic drug that also inhibits mediator release from mast cells. From previous studies, it appeared that inhibition of the influx of extracellular calcium is the major cause of this inhibition of exocytosis. Here, we explored the role of drug-membrane interactions in the inhibition of mediator release. We investigated the effects on phase transition and fluidity of artificial membranes. All compounds studied distorted the phase transition in L alpha-dipalmitoylphosphatidylcholine liposomes, which correlated with the drug induced increase in membrane fluidity measured by fluorescence anisotropy of the bilayer interacting probe 1-[4-(trimethylamino)-phenyl]-6-phenylhexa-1,3,5 triene. Erythrocytes were used to study membrane effects on a cellular level. The hypotonic-induced haemolysis of erythrocytes was inhibited by the drugs. Compounds which increased membrane fluidity of liposomes to a greater extent were also more active in decreasing haemolysis. Drug-induced disturbance of the membranes is related to their effect on the activity of store-operated Ca2+ channels. The activity of these channels in rat basophilic leukemia cells, assayed as 45Ca2+ influx, was most effectively inhibited by oxatomide derivatives, thereby inducing a more rigid membrane structure. Small changes in molecular structure affect the activity of the drugs and these structure-activity relations are discussed. PMID- 9952314 TI - The high-affinity binding of [3H]norharman ([3H]beta-carboline) to the ethanol inducible cytochrome P450 2E1 in rat liver. AB - High-affinity binding sites of [3H]norharman (synonymous: [3H]beta-carboline) were characterized in microsomal membranes from rat liver utilizing various beta carboline (BC) derivatives and substances binding to enzymes of the cytochrome P450 (CYP) superfamily (EC 1.14.14.1). Saturation experiments demonstrated that [3H]norharman binds with high-affinity (dissociation constant 20.86 nM; maximum binding 21.40 pmol/mg protein). Displacement experiments with the beta-carboline derivatives 6-methyl-BC and 6-hydroxy-BC revealed a better adaptation to the two site model, indicating that [3H]norharman binds to at least two sites, with an affinity of the high-affinity site in the low nM range. Substances binding with relative preference to isozymes of the CYP superfamily displaced [3H]norharman with a lesser potency than unlabeled norharman. Imidazole, pyrazole, and 4 methylpyrazole, known as inducers of the ethanol-inducible CYP2E1, displaced [3H]norharman with relative high potency. Furthermore, binding experiments with microsomes from human lymphoblast-expressed rat CYP2E1 revealed a high-affinity binding site [inhibition constant (Ki) 13.21 nM] comparable to that of microsomal membranes for norharman. It was displaceable by ethanol (Ki 14.25 microM), indicating that norharman and ethanol bind to the same binding site on CYP2E1. In vivo experiments with rats which had ingested ethanol for two weeks revealed that norharman blood plasma levels were significantly elevated at the end of this period, supporting the notion of an interaction of norharman and ethanol metabolism. Since it has been demonstrated in the Ames test that norharman's comutagenic action is connected with microsomal membranes (containing CYP isozymes), the present findings suggest that the observed increase in the levels of norharman in alcoholics leads to further CYP enzyme induction and thereby contributes to the increased risk of carcinomas in these patients. PMID- 9952315 TI - Greater synergism of retinoic acid receptor (RAR) agonists with vitamin D3 than that of retinoid X receptor (RXR) agonists with regard to growth inhibition and differentiation induction in monoblastic leukemia cells. AB - Retinoids and 1alpha,25-dihydroxyvitamin D3 (VD3) cooperatively induce the differentiation of myeloid leukemia cells. We investigated the role of retinoid receptors (RARs and RXRs) in the combined effects of retinoids and VD3 on growth inhibition and differentiation induction in human monoblastic leukemia U937 cells by using RAR- or RXR-selective retinoids. An isobologram analysis showed that both combinations were synergistic with regard to inhibiting the proliferation, and RAR agonists exhibited greater synergism with VD3 than did RXR agonists. RXR agonists alone induced nitroblue tetrazolium (NBT) reduction and expression of CD11b in U937 cells, whereas RAR agonists alone did not. On the other hand, RAR agonists and RXR agonists enhanced the differentiation induced by VD3, but RXR agonists required higher concentrations. An RAR antagonist inhibited the differentiation induced by RAR agonists plus VD3, but not that induced by RXR agonists plus VD3. Thus, RARs and RXRs act differently in their synergism with VD3. RAR agonists are more potent than RXR agonists with regard to synergism with VD3, and their combination may be useful in differentiation therapy against myeloid leukemia. PMID- 9952317 TI - Agonist-induced release of splice variants of the alpha subunit of the stimulatory G-protein from rat cardiac membranes. AB - It was the aim of the present study to evaluate whether, in physiological cardiac tissue, long and short splice variants of G(s)alpha (the alpha subunit of the stimulatory G-protein) differ in their susceptibility to guanine nucleotide mediated activation. As a measure of G(s)alpha activation, we determined the proportion of G(s)alpha subunits which were released from the plasma membrane upon stimulation. Membrane preparations from heart ventricles of Wistar rats were incubated with increasing concentrations of the non-hydrolyzable GTP analogue guanylyl-imidodiphosphate (GppNHp, 0-100 micromol/L) in the absence or presence of the beta-adrenoceptor agonist isoprenaline (1 micromol/L). The 45 and 52 kDa forms of G(s)alpha (G(s)alpha-S and -L, respectively) were measured in the supernatant of the incubation mixture by immunoblotting and densitometry. The increase in cyclic AMP induced by GppNHp was measured in the same supernatant. In the absence of isoprenaline, GppNHp increased cyclic AMP formation and the concentration-dependent release of G(s)alpha-L (Friedman test, P < 0.05), whereas the amount of soluble G(s)alpha-S was not affected. After addition of isoprenaline, the redistribution of G(s)alpha-S into the soluble fraction could be stimulated by GppNHp in a concentration-dependent manner (P < 0.05). Kinetic experiments revealed that activation of G(s)alpha-S by GppNHp was rather slow, but could be markedly enhanced by isoprenaline. Thus, it is likely that the different susceptibilities of G(s)alpha-S and -L towards GppNHp reflects differences in the rate of spontaneous GDP release. PMID- 9952316 TI - Removal by human apurinic/apyrimidinic endonuclease 1 (Ape 1) and Escherichia coli exonuclease III of 3'-phosphoglycolates from DNA treated with neocarzinostatin, calicheamicin, and gamma-radiation. AB - DNA strand breaks with terminal 3'-phosphoglycolate groups are produced by agents that can abstract the hydrogen atom from the 4'-carbon of DNA deoxyribose groups. Included among these agents are gamma-radiation (via the OH radical) and enediyne compounds, such as neocarzinostatin and calicheamicin. However, while the majority of radiation-induced phosphoglycolates are found at single-strand breaks, most of the phosphoglycolates generated by these two enediynes are found at bistranded lesions, including double-strand breaks. Using a 32P-post-labelling assay, we have compared the enzyme-catalyzed removal of phosphoglycolates induced by each of these agents. Both human apurinic/apyrimidinic endonuclease 1 (Ape 1) and its Escherichia coli homolog exonuclease III rapidly removed over 80% of phosphoglycolates from gamma-irradiated DNA, although there appeared to be a small resistant subpopulation. The neocarzinostatin-induced phosphoglycolates were removed more slowly, though not to completion, while the calicheamicin induced phosphoglycolates were extremely refractory to both enzymes. These data suggest that unless other enzymes are capable of acting upon the phosphoglycolate termini at enediyne-induced double-strand breaks, such termini will be resistant to end rejoining repair pathways. PMID- 9952318 TI - Reduced sensitivity of HeLa cells to cis-platinum by simultaneous overexpression of copper, zinc-superoxide dismutase and catalase. AB - The overexpression of catalase or Cu,Zn-superoxide dismutase (Cu,Zn-SOD) did not affect the sensitivity of HeLa cells to cis-platinum. However, the cytotoxicity of cis-platinum was depressed significantly by the simultaneous overexpression of catalase and Cu,Zn-SOD. We concluded that cis-platinum accelerated the generation of superoxide anion in the cells, and the superoxide anion produced was converted into H2O by the cooperative roles of catalase and Cu,Zn-SOD. PMID- 9952319 TI - Enzymatic reduction studies of nitroheterocycles. AB - The nitroimidazole derivative Megazol is a highly active compound used against several strains of Trypanosoma cruzi, the causative agent of Chagas' disease (American trypanomiasis). With the aim of gaining an insight into the probable mode of action, the interaction of Megazol with different redox enzymes was studied in comparison to that of Nifurtimox and Metronidazole. The three nitroaromatic compounds are reduced by L-lactate cytochrome c-reductase, adrenodoxin reductase, and NADPH:cytochrome P-450 reductase (EC 1.6.2.4), the efficiencies of the enzymatic reductions being roughly related to the reduction potentials of these pseudo-substrates. As the enzyme responsible for the reduction of Megazol within the parasite has not yet been identified, the nitroimidazole was assayed with T. cruzi lipoamide dehydrogenase and trypanothione reductase. Megazol did not inhibit the physiological reactions but proved to be a weak substrate of both flavoenzymes. The single electron reduction of the compound by NADPH:cytochrome P-450 reductase, by rat liver as well as by trypanosome microsomes was confirmed by ESR experiments. As shown here, Megazol interferes with the oxygen metabolism of the parasite, but its extra activity when compared to Nifurtimox may be related to other features not yet identified. PMID- 9952320 TI - In vivo iron mobilisation evaluation of hydroxypyridinones in 59Fe-ferritin loaded rat model. AB - Although there are a number of well-characterised animal models available for testing and comparing the efficacy of iron chelators, most are expensive to operate and are not capable of providing rapid and reproducible results. The method described herein is based on the labelling of rat liver with 59Fe using rat 59Fe-ferritin. This method produces highly reproducible data of the type necessary for dose-response investigations, comparison of the efficacies of different administration routes, and structure activity studies. PMID- 9952321 TI - Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo 4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5 thienoylamino-L-glutamic acid (AG2034): comparison across sensitive and resistant human tumor cell lines. AB - Folic acid (PteGlu)-enhanced intense synergy has been observed between nonpolyglutamylatable dihydrofolate reductase (DHFR) inhibitors and polyglutamylatable inhibitors of other folate-requiring enzymes, such as glycinamide ribonucleotide formyltransferase (GARFT) and thymidylate synthase. Since this phenomenon is potentially therapeutically useful, we explored its universality by examining the combined action of a DHFR inhibitor, trimetrexate (TMQ), with a GARFT inhibitor, 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H pyrimidino[5,4,6][1,4]++ +thiazin-6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034), in eight human cultured cell lines. Using a 96-well plate cell growth inhibition assay, four ileocecal adenocarcinoma cell lines [HCT-8, HCT 8/DW2 (Tomudex-resistant), HCT-8/DF2 (Tomudex-/FdUrd-resistant), and HCT-8/50 (adapted to 50 nM PteGlu)], three head and neck carcinoma cell lines [A253, FaDu, and Hep-2/500 (FdUrd-resistant)], and a non-small cell lung carcinoma cell line [H460] were treated for 96 hr with TMQ + AG2034 in the presence of 23 or 40 microM PteGlu. Cell growth was measured with the sulforhodamine B assay at the end of this period. Drug interactions were assessed by fitting a 7-parameter model including a synergism parameter, alpha, to data with weighted nonlinear regression. Isobologram analysis was also applied. At 23 microM PteGlu, cells exhibited similar intensities of Loewe synergy for the combination of TMQ + AG2034. Loewe synergy was abolished in HCT-8/50 cells cultured and studied in 50 nM PteGlu. At 40 microM PteGlu, the intensity of the combined action in all cell lines was increased However, the most intense Loewe synergy was seen with HCT-8, HCT-8/DF2, H460, FaDu, A253, and Hep-2/500 cells, whereas the HCT-8/50 subculture showed less of the phenomenon, and PteGlu enhancement was the least with HCT 8/DW2, a subline deficient in folylpolyglutamate synthetase (FPGS). The universality of the PteGlu-enhanced intense synergy phenomenon is suggested. Impaired FPGS activity and low-folate adaptation prior to treatment significantly lessen the degree of PteGlu enhancement. PMID- 9952322 TI - Biochemical basis for a cholesterol-lowering activity of 2-[2"-(1",3"-dioxolane)] 2-methyl-4-(2'-oxo-1'-pyrrolidinyl)-6- nitro-2H-1-benzopyran (SKP-450), a novel antihypertensive agent. AB - Administration (p.o.) of SKP-450, 2-[2"-(1",3"-dioxolane)]-2-methyl-4-(2'-oxo-1' pyrrolidinyl)-6-nitro-2H- 1-benzopyran, a novel antihypertensive agent, to hypercholesterolemic Syrian hamsters led to a significant reduction in plasma lipids in a dose-dependent manner, i.e., a 10.8% to 29% reduction in low-density lipoprotein cholesterol at doses of 0.3 to 10 mg/kg of SKP-450. SKP-450 was found to specifically inhibit the hepatic microsomal lanosterol 14alpha-methyl demethylase (14alpha-DM) in a competitive manner (Ki:2.65 microM). Furthermore, a dose-dependent decrease in the 14alpha-DM activity by SKP-450 parallelled the cholesterol synthetic rate in vitro in both the rat hepatic S10 fractions (supernatants at 10,000 g; IC50:20 microM) and Chinese hamster ovary cells (IC50:23 microM). However, this phenomenon was not seen in AR45 cells, which are deficient in 14alpha-DM, suggesting that 14alpha-DM is the major target for the inhibitory action of SKP-450 in regard to cholesterol biosynthesis. PMID- 9952323 TI - Endoscopy of the navicular bursa: a new technique for the treatment of contaminated and septic bursae. AB - A technique for evaluation of the navicular bursa using a 4 mm 25 degrees inclined view arthroscope is described. This allows examination of the palmar/plantar surface of the navicular bone, the insertions of the navicular suspensory, T and impar ligaments, the bursal synovium and the dorsal surface of the deep digital flexor tendon. The technique was used in 16 horses with punctures of the navicular bursa. Procedures facilitated by the technique were bursal lavage, removal of pannus, synovial resection and debridement of lesions on the palmar/plantar surface of the bone and in the deep digital flexor tendon. Following treatment, 10 animals were sound and returned to their pre-injury use and 6 animals had persistent lameness; 2 of these were salvaged after neurectomy, 1 was retired for use as a broodmare and 2 were destroyed. In contrast to the 'streetnail' procedure, the reported technique is less invasive and post operative care is simpler. The success rate is also better. Endoscopically guided treatment therefore appears to offer an advantage in the treatment of contaminated or septic navicular bursae. PMID- 9952324 TI - Tenosynovitis associated with longitudinal tears of the digital flexor tendons in horses: a report of 20 cases. AB - The paper describes a series of cases with longitudinal tears in the superficial or deep digital flexor tendons within the digital flexor tendon sheath. This appears to be a previously unreported condition. Twenty cases are described, one horse was affected bilaterally. Nineteen defects involved the deep digital flexor tendon and in 2 horses the manica flexoria of the superficial digital flexor tendon was torn. All affected horses were lame and there was marked distension of the digital flexor tendon sheaths. Ultrasonography revealed nonspecific signs of chronic tenosynovitis but not the cause. Diagnosis was established by tenoscopy in 9 cases and by open surgical exploration in the remainder. In 7 limbs, the deep digital flexor tendon lesions were treated by removal of the torn fibrils under tenoscopic control. In the remaining cases they were removed and the defects were repaired with absorbable suture material. Wound closure in all open cases included repair of the palmar/plantar annular ligament. Eleven horses became sound and returned to work, 3 improved but were lame on returning to work and 2 horses did not improve following treatment. At the time of reporting, 4 horses are sound and in controlled ascending exercise regimes. It is concluded that longitudinal tears of the digital flexor tendons should be considered in the differential diagnosis of tenosynovitis of the digital flexor tendon sheath. The results presented suggest that accurate diagnosis and specific treatment justify surgical investigation. PMID- 9952325 TI - Effects of inhaled dry powder ipratropium bromide on recovery from exercise of horses with COPD. AB - The present study evaluated ventilatory, cardiovascular and metabolic parameters during recovery from strenuous exercise in horses suffering from a crisis of chronic obstructive pulmonary disease (COPD) and to determine whether ipratropium dry powder inhalation (DPI) before exercise has an effect on these parameters. When 6 saddle horses, affected with COPD, developed airway obstruction, they inhaled placebo and ipratropium (2400 microg/horse), the order being randomly chosen. Pulmonary function tests were then recorded 15 min after inhalation. Following these tests, the horses underwent a strenuous treadmill exercise, followed by a recovery period that consisted of a 10 min walk. Measurements were made at the first and tenth min of recovery. Respiratory flow, O2 and CO2 fractions in the respired gas, pleural pressure changes and heart rate were recorded. Arterial and mixed venous blood samples were analysed for gas tensions, haemoglobin and plasma lactate concentrations. Oxygen consumption (VO2), CO2 production, tidal volume, alveolar oxygen tension (PAO2), alveolar ventilation, the alveolar-pulmonary capillary oxygen difference ((A-a)dO2) and total pulmonary resistance (RL) were measured. The PAO2 was the only parameter significantly improved during recovery following ipratropium DPI. This improvement was not accompanied by evidence of improvement of other ventilatory or cardiorespiratory parameters. The results showed that in horses suffering from a crisis of COPD, recovery is characterised by an exercise-induced bronchodilation. Secondly, ipratropium DPI at a dose of 2400 microg/horse is an effective bronchodilator in these horses at rest but it has little effect on the airway calibre during the recovery period. It is suggested that the short term recovery period is still influenced by exercise-induced adjustments that may exceed the bronchodilatory effect of inhaled ipratropium that are observed before exercise. PMID- 9952326 TI - The effect of orthopaedic shoeing on the force exerted by the deep digital flexor tendon on the navicular bone in horses. AB - This study quantifies both the intended effect of orthopaedic shoeing to decrease the load on the navicular bone and the eventual undesired effects on gait performance. The compressive force exerted by the deep digital flexor tendon on the navicular bone and on the quality of the trot and redistribution of forces over the flexor tendons and the suspensory ligament were studied as a function of orthopaedic shoeing in 12 sound Dutch Warmblood horses. A modified CODA-3 gait analysis system and a force plate were used to quantify objectively the load on the lower limb. The quality of the trot was assessed using the same gait analysis system while the horses were trotting on the treadmill. The effects of shoes with heel wedges and egg-bar shoes were compared to flat shoes and unshod feet. When heel wedges were applied, the maximal force on the navicular bone was reduced by 24% (P<0.05) in comparison with flat shoes. Egg-bar shoes did not reduce the force on the navicular bone, but in unshod feet this force appeared to be 14% lower (P<0.05) compared to flat shoes. Egg-bar shoes cause the horse's trot to be slightly less animated (P<0.05), compared to flat shoes and shoes with heel wedges. It is concluded that shoes with heel wedges reduce the force on the navicular bone as a result of a decreased moment of force at the distal interphalangeal joint in combination with a decreased angle between the deep digital flexor tendon distally and proximally of the navicular bone. Therefore it can be expected that in horses suffering from navicular disease, heel wedges will have the expected beneficial effect on the pressure on the navicular bone, while the effect of egg-bar shoes remains doubtful. PMID- 9952327 TI - Physiological responses of horses to a treadmill simulated speed and endurance test in high heat and humidity before and after humid heat acclimation. AB - To investigate whether horses were able to acclimate to conditions of high temperature and humidity, 5 horses of different breeds were trained for 80 min on 15 consecutive days on a treadmill at 30 degrees C and 80%RH. Training consisted of a combination of long duration low-intensity exercise, medium duration medium intensity exercise and short duration high intensity exercise. Between training sessions the horses were maintained at 11+/-3 degrees C and 74+/-2%RH. Before (PRE-ACC) and after acclimation (POST-ACC) the horses undertook a simulated Competition Exercise Test (CET), designed to represent the Speed and Endurance Test of a 3-day event, at 30 degrees C/80%RH. Maximal oxygen uptake (VO2PEAK) was not changed following acclimation (PRE-ACC 141+/-8 ml/min/kg bwt vs. POST-ACC 145+/-9 ml/min/kg bwt [STPD], P>0.05). Following acclimation, 4 of the 5 horses were able to complete a significantly greater amount of Phase D in the CET (PRE ACC 6.3+/-0.3 min vs. POST-ACC 7.3+/-0.3 min, P<0.05; target time = 8 min). Resting body temperatures (pulmonary artery [TPA], rectal [TREC] and tail-skin [TTSK] temperatures) were all significantly lower following acclimation. During exercise, metabolic heat production (M) and heat dissipation (HD), for the same exercise duration, were both significantly lower following acclimation (P<0.05), although heat storage (HS) was significantly higher (P<0.05). The higher heat storage following acclimation was associated with a lower TTSK for a given TPA and a decreased total fluid loss (% bodyweight, P<0.05). Plasma volume was not changed following acclimation. The relationship of sweating rate (SR) to TPA or TTSK on either the neck or the gluteal region was not significantly altered by acclimation, although the onset of sweating occurred at a lower TPA or TTSK following acclimation (P<0.05). The horses in the present study showed a number of physiological adaptations to a period of 15 days of exposure to high heat and humidity consistent with a humid heat acclimation response. These changes were mostly similar to those reported to occur in man and other species and were consistent with thermal acclimation and an increased thermotolerance, leading to an improved exercise tolerance. It is concluded that a 15 day period of acclimation is beneficial for horses from cooler and or drier climates, that have to compete in hot humid conditions and that this may redress, to some extent, the decrement in exercise tolerance seen in nonacclimated horses and reduce the risk of heat related disorders, such as heat exhaustion. PMID- 9952329 TI - Post operative performance of racing Standardbreds treated arthroscopically for carpal chip fractures: 176 cases (1986-1993). AB - A retrospective study of 176 Standardbred horses that had arthroscopic surgery for carpal chip fractures over a 7 year period was done in order to determine fracture location and post operative performance. Chip fractures of the proximal third carpal bone and the distal radiocarpal bone occurred with equal frequency (49.2 and 49.6% respectively), and chip fractures involving the antebrachiocarpal joint were rare. Trotters had significantly more third carpal bone lesions than radiocarpal bone lesions when compared to pacers (P = 0.0304). Seventy-four per cent of horses made at least one start following surgery. Pacers were significantly more likely to have at least one start after surgery than were trotters (P = 0.0009). Median earnings per start significantly decreased after surgery (P = 0.0081), while median race mark significantly increased after surgery (P = 0.0100). It is concluded that the majority of Standardbreds will be useful racehorses following carpal arthroscopy; however, most earn less money per start and many race at a lower class. PMID- 9952328 TI - Skeletal muscle metabolic response to exercise in horses with 'tying-up' due to polysaccharide storage myopathy. AB - Polysaccharide storage myopathy (PSSM) is a distinct cause of exertional rhabdomyolysis in Quarter Horses that results in glycogen and abnormal polysaccharide accumulation. The purpose of this study was to determine if excessive glycogen storage in PSSM is due to a glycolytic defect that impairs utilisation of this substrate during exercise. Muscle biopsies, blood lactates and serum CK were obtained 1) at rest from 5 PSSM Quarter Horses, 4 normal Quarter Horses (QH controls) and 6 Thoroughbreds with recurrent exertional rhabdomyolysis (TB RER) and 2) after a maximal treadmill exercise test in PSSM and QH controls. In addition, 3 PSSM horses performed a submaximal exercise test. At rest, muscle glycogen concentrations were 2.4x and 1.9x higher in PSSM vs. QH controls or TB RER, respectively. Muscle lactates at rest were similar between PSSM and QH controls but significantly higher in PSSM vs. TB RER. Muscle glucose 6-phosphate concentrations were also higher in PSSM horses than controls combined. During maximal exercise, mean muscle glycogen concentrations declined 2.7x more and mean lactate increased 2x more in PSSM vs. QH controls; however, differences were not statistically significant. Blood lactate concentrations after maximal exercise did not reflect generally higher muscle lactate in PSSM vs. QH controls. No change in blood lactate concentrations occurred in PSSM horses with submaximal exercise. Serum CK activity increased significantly 4 h after maximal and submaximal exercise and was significantly higher in PSSM vs. QH controls. These results show that during maximal exercise, PSSM horses utilised muscle glycogen and produce lactic acid via a functional glycolytic pathway and that during submaximal exercise oxidative metabolism was unimpaired. The excessive glycogen storage and formation of abnormal polysaccharide in PSSM horses therefore appear to reflect increased glycogen synthesis rather than decreased utilisation. The specific subset of horses with exertional rhabdomyolysis due to PSSM would likely benefit clinically from a diet low in soluble carbohydrates like grain with fat added as well as gradually increasing daily exercise to reduce excessive glycogen accumulation and enhance utilisation. PMID- 9952330 TI - Differences in second-intention wound healing between horses and ponies: macroscopic aspects. AB - Second-intention healing of deep wounds was studied in 5 horses and 5 ponies. Standardised wounds were created on the distal limbs and hind quarters. Wounds on the metatarsi extended onto the metatarsal bone; the depth of the wounds in the femoral biceps muscle was 18 mm. The wound margins were marked by tattoos. Photographs were taken at weekly intervals to determine the wound area. The relative contribution of contraction and epithelialisation to wound closure was quantified by means of the tattoos. Swelling of the limbs was measured; and regularity and aspect of the granulation tissue were semi-quantitatively scored. Second-intention wound healing occurred significantly faster in ponies than in horses, and muscle wounds healed significantly faster than metatarsal wounds. These marked differences reflected the greater contribution of contraction to wound healing. Moreover, demarcation was seen earlier and a healthy granulation bed developed more rapidly in ponies, whereas in horses the granulation tissue remained irregular and purulent for longer. Healing of the metatarsal wounds of horses differed markedly from that of all other wounds: these wounds increased to almost twice their original size in the first 2 weeks, exuberant granulation tissue was persistent, epithelialisation started later, and contraction played a minor role in wound closure. Limb swelling was greater in horses than in ponies. Periosteal new bone formation was more extensive, and was active over a longer period in the metatarsal bones of horses than of ponies. From this study it is concluded that second-intention healing of deep wounds occurs faster in ponies than in horses. This difference can be largely attributed to a more pronounced and faster wound contraction in ponies than in horses. Therefore, attempts to improve second-intention wound healing in clinical practice should be directed at stimulation of wound contraction. PMID- 9952331 TI - Differences in second-intention wound healing between horses and ponies: histological aspects. AB - The histological aspects of second-intention healing were studied in 5 horses and 5 ponies. Biopsies were taken weekly from standardised wounds on the metatarsus and femoral biceps muscle of one horse and one pony. Sections were stained to enable cell counting and the detection of DNA synthesis, fibrin, smooth muscle actin (SMA), collagen, and bacteria. In the ponies, the number of polymorphonuclear leucocytes (PMNs) was high during the first 3 weeks and subsequently decreased rapidly. In the horses, the initial number of PMNs was lower, but remained persistently elevated during the evaluation period. PMNs were found mainly in the superficial zones. Significantly more fibrin was present in the wounds of the horses. No significant differences were observed in the number of fibroblasts, the amounts of SMA and collagen. However, myofibroblasts were significantly less regularly organised in the wounds of the horses, particularly in the metatarsal wounds. The mitotic activity of the epithelium was temporally reduced in week 3. The mitotic activity of the granulation tissue was initially high but declined rapidly from week 1 onwards, with the exception of the metatarsal wounds of the horses, in which mitotic activity remained significantly higher. Histology confirmed and explained the macroscopical differences in wound healing between horses and ponies by the strict organisation of the myofibroblasts and the more effective acute inflammation in the ponies. Stimulation of the organisation of myofibroblasts and improvement of the efficacy of the inflammatory response in horses may therefore result in better second intention wound healing in horses in clinical practice. PMID- 9952332 TI - A field survey on the distribution of strongyle infections of horses in Sweden and factors affecting faecal egg counts. AB - Faecal egg counts were performed during the first quarter of 1995 on samples from 1183 horses of varying breeds, ages and gender on 110 farms in 3 regions of Sweden. The majority of the horses had been treated with ivermectin or pyrantel when stabled the previous autumn. The risk of reinfection with strongyles between treatment and sampling was therefore considered to be minimal. Consequently, the results reflect primarily the occurrence of worms originating from inhibited strongyle larvae refractory to anthelmintic treatment. A total of 922 (78%) individuals were found to shed strongyle eggs, and 15 (14%) of the farms studied had at least one horse infected with Strongylus vulgaris. There was a significant, gradual decrease in faecal egg output in horses originating from the southern to the northern part of Sweden. Horses from studfarms showed significantly higher numbers of strongyle eggs/g faeces (EPG) as compared to those on other types of farms, such as riding-schools and boarding stables. However, there was no correlation between herd size and mean herd EPG. The output of strongyle eggs was highest in horses aged 2 and 3 years. EPG values then declined with increasing age of the horse. Horses treated with ivermectin in the previous autumn showed significantly lower EPG values than untreated horses and those treated with pyrantel pamoate. PMID- 9952333 TI - Naturally occurring osteoarthritis in the metacarpophalangeal joints of wild horses. AB - This study identified changes consistent with osteoarthritis; articular cartilage damage, subchondral bone sclerosis and marginal osteophytes, in the metacarpophalangeal joints of wild New Zealand horses. The articular cartilage lesions were identified by Indian ink staining techniques and histology. The lesions occurred on the proximodorsal aspect of the first phalanx (P1) and were more severe on the medial compared to the lateral eminence of the bone, and their severity increased with age. The bone mineral density of the subchondral bone underlying the cartilage lesions, assessed using conventional radiography and dual energy absorptiometry, also increased with age and with severity of the overlying cartilage lesion. Subjective assessment of cabinet radiographs revealed that the subchondral bone sclerosis was greater in horses with severe articular cartilage damage. Ossicles, with a distinct trabecular bone pattern, were identified at the proximo-dorsal margin of P1 in 8 specimens from 5 horses from the older age groups (greater than age 5 years). The results of this study demonstrate age-related changes consistent with osteoarthritis in the metacarpophalangeal joints of wild horses. There appears to be a significant relationship between subchondral bone sclerosis and overlying cartilage degeneration in the proximodorsal aspect of P1. We have identified an age-related osteoarthritic process naturally present in horses; and postulate that the stresses of racing and training may accelerate this ageing process. PMID- 9952334 TI - Unreliable rectal absorption of cisapride in horses. PMID- 9952335 TI - Autosomal trisomy in a Thoroughbred colt: 65,XY,+31. PMID- 9952336 TI - Genetic dissection of murine susceptibilities to liver and lung tumors based on the two-stage concept of carcinogenesis. AB - Inbred mouse strains exhibit strain-specific susceptibilities to spontaneous and induced tumors, indicating that the individual risks for neoplastic development are largely under genetic control. Recent advances in linkage analysis have made it routine to chromosomally map the mouse genes responsible for the strain variations in tumor susceptibility using segregating crosses. It is also possible to characterize their biological functions using the positional information. These types of studies are still severely hampered for human cases due to the remarkable genetic heterogeneity and impossibility of experimental crosses. In this article, previous work on genetic susceptibility to mouse liver and lung tumors is reviewed in view of the classical two-stage concept of carcinogenesis. According to this central concept, the tumor susceptibility genes should affect either the first stage, 'initiation', or the second stage, 'promotion', or both. At least some genes seem to be specifically involved in initiation or promotion, in line with the fact that initiation and promotion are due, to a certain extent, to independent mechanisms. This notion should be also applicable to human carcinogenesis and may provide important clues for prevention of initiation and promotion in populations with a genetic predisposition for cancer development. PMID- 9952337 TI - Clinicopathological study of severe chronic active Epstein-Barr virus infection that developed in association with lymphoproliferative disorder and/or hemophagocytic syndrome. AB - Chronic active Epstein-Barr virus (CAEBV) infection has been previously reported to be sometimes associated with an aggressive clinical course. However, the role of EBV in the CAEBV is not well clarified. A retrospective study was performed on nine adult and five child patients (eight males and six females). Histologically, at first admission, the presence of neoplastic lesions could not be confirmed. The lymph nodes in half of all cases revealed paracortical hyperplasia with transformed lymphocytes (hyperplastic type). Half of the cases showed non suppurative necrosis and an increased number of histiocytes with phagocytosis (histiocytic type). Activated histiocytes with lymphokine positivity were frequently detected in the histiocytic type. In the phenotypical study, 10 of the examined 11 cases showed increased numbers of natural killer (NK) cells and/or CD8-positive T lymphocytes. In situ hybridization (ISH) showed EBV-infected lymphoid cells, but the number of EBV-infected cells varied. Double-labeling immunochemistry/ISH demonstrated EBV-infected T cells, including NK cells, but not B cells. In addition, three cases showed a monoclonal dissemination of EBV terminal repetitive sequence (TR), and two cases showed oligoclonal dissemination. From those findings, monoclonal, oligoclonal and polyclonal populations of EBV-infected T or NK cells were considered to be present in CAEBV states. During the clinical course, 12 of the 14 cases died within 5 years. Six cases died from EBV-associated hematopoietic tumors (histiocytic tumor, T cell lymphoma, B cell lymphoma, plasmacytoma, and NK cell leukemia); one from non-EBV associated acute myelogenous leukemia, and five due to hemophagocytic syndrome. The examined EBV-associated hematopoietic tumors showed monoclonal EBV terminal repetitive sequences. There is a possibility that the monoclonal dissemination of EBV-infected cells develops from oligoclonal or polyclonal EBV-infected cells. And active histiocytes with lymphokine positivity were frequently detected in the cases with histologically histiocytic type. These findings seem to be related with the causes of death due to hemophagocytic syndrome. PMID- 9952338 TI - Immunohistochemical and ultrastructural studies of basal cells, Clara cells and bronchiolar cuboidal cells in normal human airways. AB - Immunohistochemical studies were made of the distribution of various cytokeratins (CK), Clara cell secretory protein (CC10), surfactant protein A (SP-A) and type VII collagen in normal human airways. Electron microscopic studies were made to identify hemidesmosomes and anchoring fibrils on the basal surfaces of the epithelial cells. CK19 was detected in all epithelial cells, and CK17 in all basal cells. CK14 was coexpressed in a few basal cells, and this coexpression was decreased in the distal airways. Two types of basal cells were recognized. One type, found mainly in large airways, was characterized by abundant intermediate filaments and well-developed hemidesmosomes and anchoring fibrils. The second type contained few intermediate filaments and poorly developed hemidesmosomes and anchoring fibrils. Reactivity for type VII collagen was found along the basement membrane throughout the airways, but not in the alveoli. Clara cells were reactive for CC10 and CK17, but not for CK14 and SP-A. The bronchiolar cuboidal cells in the respiratory bronchioles were positive only for CK19. Surfactant protein A was present only in type II alveolar epithelial cells. Thus, two types of basal cells are present in airways, and the bronchiolar cuboidal cells appear distinct from these basal cells, Clara cells and type II alveolar epithelial cells. PMID- 9952339 TI - Immunohistochemical and gelatin zymography studies for matrix metalloproteinases in bleomycin-induced pulmonary fibrosis. AB - The role of various matrix metalloproteinases (MMP) and tissue inhibitor of metalloproteinases-2 (TIMP-2), and the gelatinolytic activities of MMP involved in the process of bleomycin-induced pulmonary fibrosis in rabbits were investigated. Male Japanese white rabbits were intubated with tracheal tubes under anesthesia, and bleomycin hydrochloride in sterile saline or only sterile saline was administered through the tracheal tubes. The animals were killed 1, 3, 7, 14 and 28 days after the administration of bleomycin (n = 3) or saline (n = 2). Light microscopic immunohistochemistry for MMP-1 (interstitial collagenase), MMP-2 (gelatinase A), MMP-9 (gelatinase B) and TIMP-2 was performed. The gelatinolytic activities of lung tissue homogenates were studied by gelatin zymography. In the early stages, the gelatinolytic activity of MMP-9 was predominant. MMP-9 localized in the infiltrating neutrophils, macrophages, bronchial and bronchiolar epithelial cells. The alveolar epithelial basement membrane was frequently disrupted in the early stages, where MMP-9 possibly contributed to the disruption. In the late stages, the gelatinolytic activities of the latent and active forms of MMP-2 were predominant, and MMP-2 localized in the regenerated alveolar epithelial cells in addition to the bronchial epithelial cells. MMP-2, especially its active form, possibly plays a role in alveolar epithelial cell regeneration. The localization of MMP-1 was similar to that of MMP-9. TIMP-2 localized in the epithelial cells and in some fibroblasts in fibrotic lesions. TIMP-2 possibly plays a role in extracellular matrix deposition in balance with MMP. PMID- 9952340 TI - Angiomyofibroblastoma of the vulva: case report. AB - Angiomyxomas are a group of relatively rare mesenchymal myxoid tumors. Three types of angiomyxomas have been identified: superficial angiomyxoma, aggressive angiomyxoma and angiomyofibroblastoma. These tumors have a predilection for occurring in the perineum of middle-aged females and are often clinically diagnosed as Bartholin's cyst. A case of a 42-year-old female with a perineal angiomyofibroblastoma mimicking a Bartholin's cyst is presented. The pathological and clinical characteristics of this tumor are discussed. PMID- 9952341 TI - Primary ovarian angiosarcoma: a case report and literature review. AB - Primary ovarian angiosarcoma is extremely rare. Only 16 cases have histologically been reported to date in the literature. A case of angiosarcoma arising in the right ovary of a 46-year-old female is presented. Grossly, the resected right ovary was completely replaced by a solid tumor mass, which revealed multiple necrotic and/or hemorrhagic foci. This case revealed the typical histological features of angiosarcoma with sinusoidal and solid patterns of anaplastic tumor cells. Immunohistochemically, tumor cells were strongly and diffusely positive for CD31 and CD34, in particular, along the cytoplasmic membrane of the tumor cells. Ultrastructurally, tumor cells possessed the intermediate junctions between tumor cells, discontinuous basal laminae attached to the irregularly shaped blood vessels and occasional cytoplasmic pinocytotic vesicles. These findings confirmed the case as being one of angiosarcoma of the ovary. The patient died 9 months after surgery as a result of developed multifocal brain metastases. A total of 17 cases reported as primary ovarian angiosarcoma, including this presented case, are clinicopathologically reviewed. PMID- 9952342 TI - Interdigitating reticulum cell tumor of lymph node: a case report and literature review. AB - Interdigitating reticulum cell (IRC) tumor is a rare tumor arising from the antigen-presenting cell - interdigitating reticulum cell. A 41-year-old male presented with lumps in the left neck and bone pain. Further investigations revealed multiple left neck and para-aortic lymphadenopathy, and multiple bony lesions. Histological examination of the lymph node showed proliferation of unusual, large, round neoplastic cells mimicking large cell lymphoma. Immunophenotypic and ultrastructural studies confirmed this tumor to be arising from an interdigitating reticulum cell. A review of reported IRC tumors illustrates the variability of this tumor in clinical and pathological features, which differ from other dendritic reticulum cell tumors. PMID- 9952343 TI - Primary ductal adenocarcinoma of the lacrimal gland. AB - The morphological similarity of salivary and lacrimal gland tumors is known. Many clinicopathological studies and characteristics of salivary duct carcinoma, which bears histological similarities to mammary duct carcinoma, have been recently reported; however, only one case of lacrimal duct carcinoma is reported. A second case of lacrimal duct carcinoma is presented. A 67-year-old male with a painless mass in the right upper eyelid underwent total removal of the tumor mass. Microscopic examination of the tumor mass revealed ductal adenocarcinoma of the lacrimal gland, which was the equivalent of salivary duct carcinoma. The immunohistological studies of the lacrimal duct carcinoma showed similar results to those reported for salivary duct carcinoma. The recurrent tumor in the subdural spaces was removed 2 years after the initial surgery and the patient is followed as an outpatient. PMID- 9952344 TI - Retroperitoneal leiomyosarcoma of a male centenarian. AB - An autopsy case of retroperitoneal leiomyosarcoma of a centenarial male is described. He complained of abdominal pain in his left side 1 month before his death. Ultrasonography and computed tomography revealed a large mass in the left abdominal cavity. At autopsy, a circumscribed mass, 15 cm in diameter, was found in the left-upper abdominal cavity, and seemed to be derived from the retroperitoneum in an exophytic manner. Histologically, spindle cells with slight eosinophilic cytoplasm and blunt-ended nuclei showed interwoven fascicular growth, and mitotic figures were easily encountered. Immunohistochemically, the tumor cells were labeled by alpha-smooth muscle actin and vimentin. To our knowledge, this case of leiomyosarcoma has presented in the oldest patient ever reported. The rarity of soft tissue sarcomas in the extremely elderly is also discussed. PMID- 9952345 TI - Sarcomatous dermatofibrosarcoma protuberans metastasized to the lung: preservation of CD34 expression in tumor cells. AB - A case of metastatic dermatofibrosarcoma protuberans (DFSP) in a 47-year-old woman is presented. Dermatofibrosarcoma protuberans occasionally recurs, but rarely metastasizes. The patient underwent local removal of the nuchal tumor by a general practitioner, followed by a rapid recurrence. She underwent total removal of the tumor and a diagnosis of spindle cell sarcoma was made after an incisional biopsy was performed. This lesion had both a typical DFSP-like area and a fibrosarcoma (FS)-like area. After 7 years, an abnormal lung shadow was observed and a segmental lung resection was performed. Histologically, the lung tumor was similar to the FS-like area in the nuchal tumor. Confirming CD34 expression in the tumor cells, this lung tumor was diagnosed as metastatic DFSP. Usually CD34 expression is unique to DFSP but almost negative in FS-like areas. In the present case, the FS-like area in the nuchal tumor showed decreased CD34 reactivity, as previously reported, but the FS-like area in the metastatic tumor still widely preserved CD34 expression. The presented case suggests that the FS-like area in DFSP is histogenetically different from typical FS or malignant fibrous histiocytoma. PMID- 9952346 TI - Secretory carcinoma of the breast in a 51-year-old male. AB - Approximately 100 female secretory carcinoma cases have been reported. Although this tumor was initially termed juvenile carcinoma as the patients were all children and adolescent females, subsequent reports demonstrated that it occurs in females of all ages. Moreover, to date, only five males with this tumor have been reported. As with the initial female secretory carcinoma cases, all five were children or young adults. A very rare case of non-invasive secretory carcinoma of the breast arising in a 51-year-old Japanese male is described. He presented with a lump in his left breast. The surgically resected tumor was a typical secretory carcinoma histologically, except that there was no infiltration of the surrounding stroma, and was composed of tumor cells with vacuolated cytoplasm that contained secretory materials. This case, the first recorded secretory carcinoma of the breast in a middle-aged male, demonstrates that this tumor may also arise in mature males, as is the case in females. Physicians should not rule out the possibility of a secretory carcinoma of the breast regardless of patient age and gender. PMID- 9952347 TI - Multiple giant angiomyolipomas with a polygonal epithelioid cell component in tuberous sclerosis: an autopsy case report. AB - A recent case of angiomyolipoma (AML) with a prominent component of polygonal epithelioid cells is described. A 27-year-old Japanese male with tuberous sclerosis presented with massive abdominal tumors increasing progressively in size. The patient died of respiratory disturbance and the autopsy revealed massive tumors in the bilateral kidneys, liver and lymph nodes, subependymal giant cell glioma of the brain and lymphangiomyomatosis of the lungs. The giant tumors were an unusual type of AML with a component of polygonal epithelioid cells, which showed a hepatocellular carcinoma-like pattern in some areas. Smooth muscle components comprising spindle cells, short or plump spindle cells and polygonal epithelioid cells frequently exhibited positive staining for HMB-45 but negative staining for epithelial cell markers. The unusual AML presented in this case was thought to be of low-grade malignancy and slow growing. It has been suggested that angiomyolipomas with diffuse areas of epithelioid cell component are potentially malignant. Immunostainings positive for HMB-45 but negative for epithelial cell markers are considered to be useful in differentiating AML with polygonal epithelioid cell component from other tumors, especially from renal cell carcinoma and hepatocellular carcinoma. PMID- 9952348 TI - Development of catecholaminergic neurons in the pond snail, Lymnaea stagnalis: I. Embryonic development of dopamine-containing neurons and dopamine-dependent behaviors. AB - The embryonic development of the catecholaminergic system of the pond snail, Lymnaea stagnalis, was investigated by using chromatographic and histochemical methods. High performance liquid chromatography suggested that dopamine was the only catecholamine present in significant concentrations throughout the embryonic development of Lymnaea. Dopamine first became detectable at about embryonic stage (E) 15 (15% of embryonic development) and then increased in amount during early development to reach about 120-140 fmol per animal by around E40. Dopamine content remained stable during mid-embryogenesis (E40-65), increased slowing for the next couple of days, and then increased rapidly to culminate at about 400 fmol per animal by hatching. The detection of aldehyde- and glyoxylate-induced fluorescence and of tyrosine hydroxylaselike immunoreactivity indicated that the first catecholaminergic cells appeared in the late trochophore or early veliger stage of embryonic development (E32-35). The paired perikarya of these transient apical catecholaminergic (TAC) neurons were located beneath the apical plate, remained outside of the central ganglia during embryogenesis, and no longer contained detectable catecholamines close to hatching. TAC neurons bore cilia on the ends of short processes that penetrated the overlying epithelium; their long processes branched repeatedly under the ciliated apical plate. Several smaller catecholaminergic cells first appeared in the anterior margin of the foot at a stage when the embryos began to metamorphose from the veliger form (E55). Similar bipolar cells later appeared in the tentacle and lips. The axons of all of these small peripheral cells projected centrally and terminated within the neuropil of different central ganglia. Central catecholaminergic neurons, including RPeD1, differentiated only after metamorphosis was complete (E75). Development of locomotor, respiratory, and feeding behaviors correlated with maturation of catecholaminergic neurons, as indicated by histology and chromatography. PMID- 9952349 TI - Development of catecholaminergic neurons in the pond snail, Lymnaea stagnalis: II. Postembryonic development of central and peripheral cells. AB - Catecholamines have long been thought to play important roles in different mollusc neural functions. The present study used glyoxylate- and aldehyde-induced histofluorescence to identify central and peripheral catecholaminergic neurons in the snail Lymnaea stagnalis. The majority of these cells were also found to react to antibodies raised against tyrosine hydroxylase. A minority of the catecholaminergic neurons, however, exhibited no such immunoreactivity. The number of central catecholaminergic neurons nearly doubled (from about 45 to about 80 cells) during the first 2-3 days of postembryonic development. Thereafter, catecholaminergic neurons again doubled in number and generally grew by about 100-200% in soma diameter as the snails grew by 1,000% in overall linear measurements. In contrast to the relatively meager addition of central catecholaminergic neurons, several thousand catecholaminergic somata were added to different peripheral tissues during postembryonic development. These small, centrally projecting neurons were particularly concentrated in the lips, esophagus, anterior margin of the foot, and different regions of the male and female reproductive tracts. Chromatographic analyses indicated that dopamine was the major catecholamine present in the central ganglia, foot, and esophagus, although detectable levels of norepinephrine (approximately 20% of dopamine levels) were also found in the ganglia. The total content but not the concentration of dopamine increased within the tissue samples during postembryonic development. The companion study (Voronezhskaya et al. [1999] J. Comp. Neurol. 404:285-296) and the present study furnish a complete description of central and peripheral catecholaminergic neurons from their first appearance in early embryonic development to adulthood. PMID- 9952350 TI - Nuclear respiratory factor-2 subunit protein: correlation with cytochrome oxydase and regulation by functional activity in the monkey primary visual cortex. AB - Previous studies have shown that a transcription factor of the Ets family, nuclear respiratory factor 2 (NRF-2), can activate in vitro the gene expression of cytochrome oxidase (CO), a mitochondrial enzyme of oxidative metabolism. The goals of our present study were to determine whether the distribution of NRF-2 alpha subunit proteins correlated with that of CO activity in the macaque monkey visual cortex and whether the level could be perturbed by visual deprivation. We generated polyclonal antibodies specifically against human NRF-2 alpha subunit. In normal monkeys, patterns of NRF-2 alpha distribution resembled closely that of CO activity: 1) NRF-2 alpha immunoreactivity was localized in both nuclei and cytoplasm of neurons, but the levels differed among various laminae; 2) layers IVA, IVC, and VI, which had high CO activity, were labeled more densely by NRF-2 alpha than layers I, IVB, and V, which contained lower levels of both NRF-2 alpha and CO activity; and 3) CO-rich puffs in layers II and III contained a higher level of NRF-2 alpha than CO-poor interpuffs. From 1 day to 7 days after monocular impulse blockade with tetrodotoxin, there was a progressive reduction of NRF-2 alpha in deprived ocular dominance columns, in parallel with decreases in CO activity. These results suggest that local levels of NRF-2 in the monkey visual cortex closely reflect neuronal physiological and metabolic levels revealed by CO activity and that the expression of NRF-2 alpha, like that of CO, is regulated tightly by neural functional activity. PMID- 9952351 TI - Neurotrophins and their receptors in the tench retina during optic nerve regeneration. AB - To understand the role of neurotrophins in the visual system, we investigated the distribution of both neurotrophins and their receptors within the retina of a fish that has the capacity to spontaneously regenerate its optic nerve axons after lesion. Intact retinas and retinas from tench, whose optic nerve had been crushed, were analyzed by immunohistochemistry and in situ hybridization. Trk receptors were mainly immunolocalized in cells of the inner nuclear and ganglion cell layers, a distribution coincident with that of their mRNAs. Nerve growth factor (NGF) immunoreactivity was detected exclusively in Muller cell processes, and brain-derived neurotrophic factor (BDNF) was found in both neuronal bodies and Muller cell processes. Neurotrophin-3 (NT-3) was detected in most of the cell nuclei, and neurotrophin-4/5 (NT-4/5) was localized in fibers and in a few cells in the inner retina. An increase in both TrkA protein and mRNA was detected during axonal regeneration within the retinal ganglion cell layer, reaching a maximum 30 days postcrush and returning to normal levels by day 90, when optic nerve regeneration is almost completed in this fish. None of the other neurotrophins and receptors showed appreciable changes. The heterogeneous distribution patterns of neurotrophins and their receptors in fish retina, their differences from the distribution observed in other species, and the TrkA changes after optic nerve crush suggest an important role for these molecules in the normal physiology of the fish retina and during the regeneration process. PMID- 9952352 TI - Layer VI in cat primary auditory cortex: Golgi study and sublaminar origins of projection neurons. AB - The organization of layer VI in cat primary auditory cortex (AI) was studied in mature specimens. Golgi-impregnated neurons were classified on the basis of their dendritic and somatic form. Ipsilateral and contralateral projection neurons and the corticogeniculate cells of origin were labeled with retrograde tracers and their profiles were compared with the results from Golgi studies. Layer VI was divided into a superficial half (layer VIa) with many pyramidal neurons and a deeper part (layer VIb) that is dominated by horizontal cells. Nine types of neuron were identified; four classes had subvarieties. Classical pyramidal cells and star, fusiform, tangential, and inverted pyramidal cells occur. Nonpyramidal neurons were Martinotti, multipolar stellate, bipolar, and horizontal cells. This variety of neurons distinguished layer VI from other AI layers. Pyramidal neuron dendrites contributed to the vertical, modular organization in AI, although their apical processes did not project beyond layer IV. Their axons had vertical, intrinsic processes as well as corticofugal branches. Horizontal cell dendrites extended laterally up to 700 microm and could integrate thalamic input across wide expanses of the tonotopic domain. Connectional experiments confirmed the sublaminar arrangement seen in Nissl material. Commissural cells were concentrated in layer VIa, whereas corticocortical neurons were more numerous in layer VIb. Corticothalamic cells were distributed more equally. The cytological complexity and diverse connections of layer VI may relate to a possible role in cortical development. Layer VI contained most of the neuronal types found in other layers in AI, and these cells form many of the same intrinsic and corticofugal connections that neurons in other layers will assume in adulthood. Layer VI, thus, may play a fundamental ontogenetic role in the construction and early function of the cortex. PMID- 9952353 TI - Mormyrid electrosensory lobe in vitro: morphology of cells and circuits. AB - The electrosensory lobe (ELL) of mormyrid electric fish is a cerebellum-like brainstem structure that receives the primary afferent fibers from electroreceptors in the skin. The ELL and similar sensory structures in other fish receive extensive input from other central sources in addition to the peripheral input. The responses to some of these central inputs are adaptive and serve to minimize the effects of predictable sensory inputs. Understanding the interaction between peripheral and central inputs to the mormyrid ELL requires knowledge of its functional circuitry, and this paper examines this circuitry in the in vitro slice preparation and describes the axonal and dendritic morphology of major ELL cell types based on intracellular labeling with biocytin. The cells described include medium ganglion cells, large ganglion cells, large fusiform cells, thick-smooth dendrite cells, small fusiform cells, granule cells, and primary afferent fibers. The medium ganglion cells are Purkinje-like interneurons that terminate on the two types of efferent cells, i.e., large ganglion and large fusiform cells, as well as on each other. These medium ganglion cells fall into two morphologically distinct types based on the distributions of basal dendrites and axons. These distributions suggest hypotheses about the basic circuit of the ELL that have important functional consequences, such as enhancement of contrast between "on" elements that are excited by increased afferent activity and "off" elements that are inhibited. PMID- 9952354 TI - Development and further characterization of a small subclass of rat olfactory receptor neurons that shows immunoreactivity for the HSP70 heat shock protein. AB - We previously described a rat olfactory receptor neuron (ORN) subpopulation [the 2A4(+) ORNs] that shows uniquely strong reactivity with antibodies to the 70-kD heat shock protein (HSP70) family of molecular chaperones (Carr et al. [1994] J. Comp. Neurol. 348:150-160). The 2A4(+)ORNs are dispersed through zones II-IV of the olfactory epithelium (OE), and their axons project to only two or three glomeruli that are located consistently in each olfactory bulb (OB). To date, the 2A4(+)ORN subpopulation is the only cell population to show such distinct HSP70 immunoreactivity as well as the most discrete ORN subpopulation to be so labeled. The present report shows that 2A4(+)ORN neurons first appear between postnatal days 7 (P7) and P10. Initially, low cell numbers rise to a density of 0.1 2A4(+)ORNs/mm OE length by P14, plateau at 0.9 2A4(+)ORNs/mm by P49, then fall to adult values of 0.4 cells/mm. Autoradiographic birthdating indicates that almost all of these early appearing 2A4(+)ORNs are generated postnatally, in contrast to the prenatal generation of all ORN subpopulations characterized to date by their expression of olfactory receptor protein mRNAs. A developmentally related increase in the mean depth of 2A4(+)ORNs within the OE also occurs. In the OB, initial 2A4(+)axonal projections are to only two or three glomeruli, as in adults. Slight but significant rostral shifts in (+)glomerular location occur with development. The 2A4(+)ORN immunoreactivity was found to be due to expression of HSP70, the dominant stress-inducible member of the HSP70 family, rather than constitutively expressed HSC70. In addition, despite their presence in rat OE, no 2A4(+)ORNs were found in mice, gerbils, guinea pigs, or hamsters. PMID- 9952355 TI - Immunohistochemistry and spinal projections of the reticular formation in the northern leopard frog, Rana pipiens. AB - Over 30 nuclei have been identified in the reticular formation of rats, but only a small number of distinct reticular nuclei have been recognized in frogs. We used immunohistochemistry, retrograde tracing, and cell morphology to identify nuclei within the brainstem of Rana pipiens. FluoroGold was injected into the spinal cord, and, in the same frogs, antibodies to enkephalin, substance P, somatostatin, and serotonin were localized in adjacent sections. We identified many previously unrecognized reticular nuclei. The rhombencephalic reticular formation contained reticularis (r.) dorsalis; r. ventralis, pars alpha and pars beta; r. magnocellularis; r. parvocellularis; r. gigantocellularis; r. paragigantocellularis lateralis and dorsalis; r. pontis caudalis, pars alpha and pars beta; nucleus visceralis secundarius; r. pontis oralis, pars medialis and pars lateralis; raphe obscurus; raphe pallidus; raphe magnus; and raphe pontis. The mesencephalic reticular formation contained locus coeruleus-subcoeruleus, r. cuneiformis, r. subcuneiformis, raphe dorsalis-raphe centralis superior, and raphe linearis. Thus, the reticular formation of frog, which is an anamniote, is organized complexly and is similar to the reticular formation in amniotes. Because many of these nuclei may be homologous to reticular nuclei in mammals, we used mammalian terminology for frog reticular nuclei. PMID- 9952356 TI - Muscarinic receptor subtypes in the lateral geniculate nucleus: a light and electron microscopic analysis. AB - Neural activity in the dorsal lateral geniculate nucleus of the thalamus (DLG) is modulated by an ascending cholinergic projection from the brainstem. The purpose of this study was to identify and localize specific muscarinic receptors for acetylcholine in the DLG. Receptors were identified in rat and cat tissue by means of antibodies to muscarinic receptor subtypes, ml-m4. Brain sections were processed immunohistochemically and examined with light and electron microscopy. Rat DLG stained positively with antibodies to the m1, m2,and m3 receptor subtypes but not with antibodies to the m4 receptor subtype. The m1 and m3 antibodies appeared to label somata and dendrites of thalamocortical cells. The m1 immunostaining was pale, whereas m3-positive neurons exhibited denser labeling with focal concentrations of staining. Strong immunoreactivity to the m2 antibody was widespread in dendrites and somata of cells resembling geniculate interneurons. Most m2-positive synaptic contacts were classified as F2-type terminals, which are the presynaptic dendrites of interneurons. The thalamic reticular nucleus also exhibited robust m2 immunostaining. Cat DLG exhibited immunoreactivity to the m2 and m3 antibodies. The entire DLG stained darkly for the m2 receptor subtype, except for patchy label in the medial interlaminar nucleus and the ventralmost C laminae. The staining for m3 was lighter and was distributed more homogeneously across the DLG. The perigeniculate nucleus also was immunoreactive to the m2 and m3 subtype-specific antibodies. Immunoreactivity in cat to the m1 or m4 receptor antibodies was undetectable. These data provide anatomical evidence for specific muscarinic-mediated actions of acetylcholine on DLG thalamocortical cells and thalamic interneurons. PMID- 9952357 TI - Developmental stages in the human thymus. AB - The thymus is populated by hematopoietic cells that have the capacity to develop into at least three different hematopoietic lineages, T, NK and dendritic cells. While developing into T cells these cells pass a series of developmental stages that can be discriminated on the basis of expression of a number of antigens. The availability of a myriad of monoclonal anti- bodies against human differentiation antigens has permitted a detailed analysis of the various cellular stages in the human thymus. This analysis not only comprised investigation of molecular but also of functional features of purified thymocyte subsets, since more recently assays were set up that allowed investigation of the hematopoietic precursor activities of human thymic progenitor cells. Here we review the current status of knowledge with regard to early developmental stages in the human thymus. In addition, we discuss recent data on later developmental stages, in particular concerning positive selection and maturation of T cells. PMID- 9952359 TI - Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons. AB - Repeated exposure to human immunodeficiency virus (HIV) does not always result in seroconversion. Understanding the conditions that permit or protect against progressive infection with HIV is important for vaccine development. Nineteen subjects at risk for HIV infection were CCR-5 genotyped and screened for virus specific memory cytotoxic T lymphocytes (CTL). None had the Delta32CCR 5/Delta32CCR-5 genotype associated with HIV resistance. HIV-specific CTL were detected in 7 (41.1%) of 17 exposed uninfected subjects versus 0 of 14 seronegative subjects with no HIV risk factors (P=.006, chi2 test). Recognition of virus by CTL in exposed uninfected subjects was major histocompatibility complex class I-restricted and multispecific, and specificity could change with time. Activity could persist up to 34 months after the last virus exposure. The presence of HIV-specific CTL in a greater proportion of seronegative HIV-exposed versus unexposed subjects supports the notion that in some cases, virus exposure induces HIV immunity without seroconversion or disease progression. PMID- 9952358 TI - The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses. AB - Twelve subjects were treated with zidovudine, lamivudine, and ritonavir within 90 days of onset of symptoms of acute infection to determine whether human immunodeficiency virus type 1 (HIV-1) infection could be eradicated from an infected host. In adherent subjects, with or without modifications due to intolerance, viral replication was suppressed during the 24-month treatment period. Durable suppression reduced levels of HIV-1-specific antibodies and cytotoxic T lymphocyte responses in selected subjects. Proviral DNA in mononuclear cells uniformly persisted. The persistence of HIV-1 RNA expression in lymphoid tissues and peripheral blood mononuclear cells suggests that elimination of this residual pool of virus should be achieved before considering adjustments in antiretroviral therapeutic regimens. In addition, given the reduction in levels of virus-specific immune responses, it would seem prudent to consider enhancing these responses using vaccine strategies prior to the withdrawal of antiviral therapy. PMID- 9952360 TI - Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects. AB - It has been hypothesized that protection against human immunodeficiency virus (HIV)-1 infection may result from either acquired host immunity, inheritance of a dysfunctional CCR5 HIV-1 coreceptor, or a low or attenuated virus inoculum. Thirty-seven HIV-1-uninfected persons engaging in repeated high-risk sexual activity with an HIV-1-infected partner were prospectively studied to determine the contribution of these factors in protecting against HIV-1 transmission. More than one-third (13/36) demonstrated HIV-1-specific cytotoxicity, and this activity significantly correlated with the wild type CCR5 genotype (P=.03). Only 1 subject (3%) demonstrated the homozygous CCR5 32-bp deletion (Delta32/Delta32). Median plasma HIV-1 RNA levels from 18 HIV-1-infected sex partners were not statistically different from those of matched infected control patients. These results indicate that inheritance of the Delta32 CCR5 mutation does not account for the majority of persistently HIV-1-resistant cases, and the presence of cellular immunity in these persons suggests either undetected infection or protective immunity. PMID- 9952361 TI - Immunization with human immunodeficiency virus type 1 rgp120W61D in QS21/MPL adjuvant primes T cell proliferation and C-C chemokine production to multiple epitopes within variable and conserved domains of gp120W61D. AB - Human immunodeficiency virus type 1 (HIV-1) gp120W61D-specific T cell lines (TCL) were generated from an HIV-1-seronegative volunteer who received rgp120W61D in QS21/MPL adjuvant with emulsion. TCL were challenged with pools of consecutive, overlapping peptides spanning the gp120W61D sequence and then with the individual peptides of the immunostimulatory pool. T cell epitopes were found within both variable and conserved domains, and there was no evidence of a single immunodominant epitope. The two most frequently recognized peptides were located in the C1 domain and in the C-terminal region of the V3 loop. Several TCL were shown to recognize multiple peptides from nonoverlapping regions. Peptides from both conserved and variable domains were capable of inducing MIP-1alpha, MIP 1beta, and RANTES production. When tested against the equivalent peptide from the HIV-1IIIB sequence, however, TCL were able to tolerate only minor conserved changes in the amino acid sequence. PMID- 9952363 TI - Virologic and immunologic response to nucleoside reverse-transcriptase inhibitor therapy among human immunodeficiency virus-infected infants and children. AB - Plasma human immunodeficiency virus RNA and CD4 lymphocyte response to nucleoside reverse-transcriptase therapy were evaluated in a large, comparative pediatric trial. Both baseline values and changes in the two laboratory markers over time correlated well with clinical outcome and possessed independent predictive value. In comparison of RNA reduction from baseline between the dideoxyinosine (ddI) and zidovudine+ddI therapeutic arms, marginal superiority of the combination arm was not correlated with an observed clinical benefit. Despite the size of this trial and the significantly higher rate of clinical end points in the zidovudine monotherapy group, attempts to establish surrogacy for plasma RNA were difficult. Nevertheless, plasma RNA and CD4 lymphocyte count together possess strong clinical predictive power and are valuable tools for both the clinician and the evaluation of new therapies. PMID- 9952362 TI - Efficacy of zidovudine and human immunodeficiency virus (HIV) hyperimmune immunoglobulin for reducing perinatal HIV transmission from HIV-infected women with advanced disease: results of Pediatric AIDS Clinical Trials Group protocol 185. AB - Pediatric AIDS Clinical Trials Group protocol 185 evaluated whether zidovudine combined with human immunodeficiency virus (HIV) hyperimmune immunoglobulin (HIVIG) infusions administered monthly during pregnancy and to the neonate at birth would significantly lower perinatal HIV transmission compared with treatment with zidovudine and intravenous immunoglobulin (IVIG) without HIV antibody. Subjects had baseline CD4 cell counts /=200/microL) but not with time of zidovudine initiation (5.6% vs. 4.8% if started before vs. during pregnancy; P=. 75). The Kaplan-Meier transmission rate for HIVIG recipients was 4. 1% (95% confidence interval, 1.5%-6.7%) and for IVIG recipients was 6.0% (2.8%-9.1%) (P=.36). The unexpectedly low transmission confirmed that zidovudine prophylaxis is highly effective, even for women with advanced HIV disease and prior zidovudine therapy, although it limited the study's ability to address whether passive immunization diminishes perinatal transmission. PMID- 9952364 TI - Impaired phagocyte oxidative capacity in human immunodeficiency virus-infected children. AB - Children infected with the human immunodeficiency virus (HIV) have T helper cell deficiency, but frequent bacterial infections suggest phagocyte dysfunction. Whole blood chemiluminescence (CL) assays were used to measure the respiratory burst capacity of phagocytes from HIV-infected children, perinatally HIV-exposed but uninfected children, and normal healthy children. Phagocytes were stimulated by zymosan opsonized with human complement with and without priming by platelet activating factor (PAF) or FMLP. Activities of enzymes involved in the respiratory burst, oxidase and myeloperoxidase, were examined after opsonin receptor-independent stimulation with PMA. Unprimed CL responses to opsonized zymosan were decreased for HIV-infected children with severe CD4 lymphocyte suppression compared with healthy children (P=.03), and PAF-primed CL responses to opsonized zymosan were decreased in HIV-infected children with both moderate and severe CD4 lymphocyte suppression (P=.02 and P=.01, respectively), despite normal or increased activities of the respiratory burst enzymes. These impairments may contribute to secondary bacterial infections. PMID- 9952365 TI - Maternal virus load and perinatal human immunodeficiency virus type 1 subtype E transmission, Thailand. Bangkok Collaborative Perinatal HIV Transmission Study Group. AB - To determine the rate and risk factors for human immunodeficiency virus (HIV)-1 subtype E perinatal transmission, with focus on virus load, pregnant HIV-infected women and their formula-fed infants were followed prospectively in Bangkok. Of 281 infants with known outcome, 68 were infected (transmission rate, 24.2%; 95% confidence interval, 19.3%-29.6%). Transmitting mothers had a 4.3-fold higher median plasma HIV RNA level at delivery than did nontransmitters (P<.001). No transmission occurred at <2000 copies/mL. On multivariate analysis, prematurity (adjusted odds ratio [AOR], 4.5), vaginal delivery (AOR, 2.9), low NK cell percentage (AOR, 2.4), and maternal virus load were associated with transmission. As RNA quintiles increased, the AOR for transmission increased linearly from 4.5 to 24.8. Two-thirds of transmission was attributed to virus load>10,000 copies/mL. Although risk is multifactorial, high maternal virus load at delivery strongly predicts transmission. This may have important implications for interventions designed to reduce perinatal transmission. PMID- 9952366 TI - Coinfection of macaques with simian immunodeficiency virus and simian T cell leukemia virus type I: effects on virus burdens and disease progression. AB - To test the hypothesis that coinfection with human immunodeficiency virus (HIV) and human T cell leukemia/lymphoma virus types I or II (HTLV-I or -II) accelerates progression to AIDS, pig-tailed macaques were inoculated with the simian counterparts, SIV and STLV-I. During 2 years of follow-up of singly and dually infected macaques, no differences in SIV burdens, onset of disease, or survival were detected. However, in the first coinfected macaque that died of AIDS (1 year after infection), >50% of CD4+ and CD8+ lymphocytes expressed CD25. On the basis of the low incidence of HTLV-I- and STLV-I-associated disease during natural infections, this early evidence of neoplastic disease was unexpected. While these results demonstrate that coinfection with SIV and STLV-I has no influence on the development of immunodeficiency disease, they do establish a reliable macaque model of persistent STLV-I infection. PMID- 9952367 TI - Phase IIa safety and immunogenicity of a therapeutic vaccine, TA-GW, in persons with genital warts. AB - A fusion protein vaccine consisting of human papillomavirus 6 L2E7 with Alhydrogel was developed for the treatment of genital warts. Twenty-seven subjects with genital warts received 3 immunizations over 4 weeks in an open label study. The vaccine was well-tolerated, and all subjects made serum IgG antibodies, predominantly IgG1, against L2E7. Nineteen of 25 tested persons made antigen-specific T cell proliferative responses to L2E7, and peripheral blood mononuclear cells when cultured with L2E7 in vitro produced both interferon-gamma and interleukin (IL)-5, although IL-5 predominated after the final vaccination. Five subjects completely cleared warts within 8 weeks. Subjects whose warts were not cleared by 8 weeks were offered conventional therapy. Recurrence of warts was not seen in any of the 13 persons whose warts cleared by vaccine alone or with conventional therapy. While these preliminary results of the use of this therapeutic immunogen are encouraging, proof of efficacy will require randomized double-blind trials. PMID- 9952368 TI - Quantitative analysis of neutralizing immune responses to human parvovirus B19 using a novel reverse transcriptase-polymerase chain reaction-based assay. AB - Infection with human parvovirus B19 causes fifth disease, acute and chronic red cell aplasia, fetal hydrops, arthropathy, and other disorders. Antiviral antibodies limit B19 infection in vivo; however, the identification of serologic markers of protection has been hampered by the lack of a quantitative assay for parvovirus neutralization. A novel in vitro test for parvovirus neutralization has been developed using reverse transcriptase-polymerase chain reaction to detect viral transcripts in a B19-permissive cell line. Parvovirus neutralizing activity was measured in sera from naturally infected individuals, and common features of sera with high neutralizing capacity were identified as protection correlates. Sera that suppressed B19 replication in vitro demonstrated IgG reactivity with capsid proteins VP1 and VP2, but no linear relationship between antibody titer and neutralizing capacity was observed. Sera from experimental animals and human volunteers immunized with a virus-like particle vaccine candidate exhibited B19 neutralizing titers equal to or greater than those observed in natural infections. PMID- 9952369 TI - Genetic linkage of exotoxin alleles and emm gene markers for tissue tropism in group A streptococci. AB - In group A streptococci, genetic markers for principal tissue reservoir are located within emm genes, which encode surface proteins that have a role in virulence. A worldwide collection of 160 isolates was evaluated for two traits: chromosomal emm gene markers for tissue tropism (designated patterns A-E), and bacteriophage-associated genes (speA and speC) encoding pyrogenic exotoxins. The speA and speC alleles of organisms harboring the emm marker for a pharyngeal reservoir (pattern A-C) differ from spe alleles that predominate in organisms with the emm marker for impetigo (pattern D). However, organisms that display the emm marker for both tissue sites (pattern E) are not intermediate for the distribution of either speA or speC alleles, but instead resemble pattern A-C isolates for speA and pattern D strains for speC. Statistically significant nonrandom associations between exotoxin alleles and emm patterns were observed but cannot be readily explained by niche separation alone. PMID- 9952370 TI - Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis. AB - Human T cell responses to ESAT-6 and eight synthetic overlapping peptides were investigated in tuberculosis (TB) patients and control subjects from regions of high and low endemicity for TB. ESAT-6 was recognized by 65% of all tuberculin purified protein derivative-responsive TB patients, whereas only 2 of 29 bacille Calmette-Guerin-vaccinated Danish healthy donors recognized this molecule. In Ethiopia, a high frequency (58%) of healthy contacts of TB patients recognized ESAT-6. All of the peptides were recognized by some donors, indicating that the molecule holds multiple epitopes. Danish and Ethiopian patients differed in the fine specificity of their peptide responses. Recognition of the C-terminal region (aa 72-95) was predominant in Danish patients, whereas recognition of aa 42-75 was predominant in Ethiopia. The relationship of these differences to the distribution of HLA types in the two populations is discussed. This study demonstrates that ESAT-6 is frequently recognized during early infection and holds potential as a component of a future TB-specific diagnostic reagent. PMID- 9952371 TI - Interleukin-12 induces sustained activation of multiple host inflammatory mediator systems in chimpanzees. AB - To determine in vivo effects of interleukin (IL)-12 on host inflammatory mediator systems, 4 healthy chimpanzees received recombinant human IL-12 (1 microg/kg) by intravenous injection. IL-12 induced increases in plasma concentrations of IL-15, IL-18, and interferon-gamma (IFN-gamma), plus a marked antiinflammatory cytokine response (IL-10, soluble tumor necrosis factor [TNF] receptors, IL-1 receptor antagonist) and secretion of alpha-chemokines (IL-8, IFN-gamma-inducible protein 10) and beta-chemokines (monocyte chemoattractant protein-1, macrophage inflammatory protein-1beta). In addition, IL-12 elicited neutrophilic leukocytosis, neutrophil degranulation (elastase-alpha1-antitrypsin complexes), coagulation activation (F1 + 2 prothrombin fragment, thrombin-antithrombin III complexes), and fibrinolytic activation (tissue-type plasminogen activator, plasmin-alpha2-antiplasmin complexes). IL-12-induced activation of multiple host mediator systems was found only after 8-24 h, remained detectable until the end of the 48-h observation period, and occurred in the absence of detectable TNF and IL-1beta. These data may contribute to understanding the role of IL-12 in the pathogenesis of sepsis syndrome and the toxicity found after repeated injections of IL-12. PMID- 9952372 TI - Lactobacilli and vaginal host defense: activation of the human immunodeficiency virus type 1 long terminal repeat, cytokine production, and NF-kappaB. AB - Lactobacilli, a component of the normal vaginal flora, can activate the human immunodeficiency virus (HIV)-1 long terminal repeat (LTR) in the Jurkat T lymphocyte and THP-1 macrophage cell lines. Activation of the LTR in Jurkat cells was strongly enhanced by vanadate and inhibited by catalase, implicating H2O2. In contrast, activation in THP-1 cells occurred in the absence of vanadate and was unaffected by catalase. The active material partitioned into the phenol layer on hot aqueous phenol extraction. Lactobacilli also increased tumor necrosis factor alphaand interleukin-1betaproduction and activated NF-kappaB in THP-1 cells and increased tumor necrosis factor-alphaproduction by human monocytes. Human vaginal fluid specimens had comparable properties, which correlated with their bacterial content. These findings suggest the presence in vaginal fluid of agent(s) derived from indigenous bacteria that can activate the HIV-1 LTR, cytokine production, and NF-kappaB in cells of macrophage lineage, with possible influence on vaginal physiology and host defense. PMID- 9952373 TI - Effective phagocytosis and killing of Candida albicans via targeting FcgammaRI (CD64) or FcalphaRI (CD89) on neutrophils. AB - Invasive fungal infections are an increasing problem for immunocompromised patients. As an approach to improve targeting of polymorphonuclear leukocytes (PMNL) toward Candida albicans, the effect of bispecific antibodies (BsAbs) directed against C. albicans and either FcalphaRI or FcgammaRI was evaluated. Control PMNL and in vivo granulocyte colony-stimulating factor (G-CSF)-primed PMNL served as effector cells. A new radiometric killing assay for measuring candidacidal activity was developed to facilitate quantification of PMNL-mediated killing of C. albicans. BsAbs directed to either FcgammaRI (CD64) or FcalphaRI (CD89) on human PMNL effectively enhanced both phagocytosis and killing of C. albicans in vitro. Fungicidal activity triggered via FcgammaRI required in vivo priming with G-CSF, whereas FcalphaRI-mediated activity was not dependent on this growth factor. Furthermore, PMNL from human FcgammaRI-transgenic mice effectively phagocytosed and eliminated C. albicans in the presence of BsAbs. These results document the capacity of FcR-directed BsAbs and G-CSF to trigger antifungal immune responses. PMID- 9952374 TI - Molecular characterization of Cyclospora-like organisms from baboons. AB - Cyclospora organisms are intestinal pathogens of humans that are increasingly recognized in many parts of the world; yet, the reservoirs and host range remain poorly defined. Analysis of 18S ribosomal DNA (rDNA) suggests that the human associated Cyclospora species (Cyc-hu) is most closely related to the Eimeria species, which are host species-specific. Recently, oocysts identical to those of Cyc-hu were detected in baboon fecal specimens from Tanzania. The 18S rDNA from 3 of these baboon-associated oocyst specimens was amplified and sequenced. Phylogenetic analysis indicated that these baboon-associated Cyclospora-like organisms (Cyc-bab) are nearly identical to each other and are distinct from Cyc hu (1.6%-1.7% dissimilar); however, these Cyc-bab organisms are the closest known relatives of Cyc-hu. Together, these primate-associated cyclosporans constitute a coherent clade within the diverse group of Eimeria species. These findings raise important questions about the evolutionary relationships of the eimeriids and Cyc hu host range and should lead to improved polymerase chain reaction-based diagnostics. PMID- 9952375 TI - RANTES, macrophage-inhibitory protein 1alpha, and the eosinophil product major basic protein are released into upper respiratory secretions during virus-induced asthma exacerbations in children. AB - The presence of cytokines and the toxic eosinophil granule product major basic protein (MBP) was investigated in nasal aspirates from children with naturally occurring virus-induced asthma exacerbations and compared with levels in nasal aspirates taken from the same children when asymptomatic. Increased levels of MBP accompanied by increased levels of the chemokines RANTES and macrophage inhibitory protein 1alpha were observed in nasal aspirates from children during the virus-induced exacerbations. Granulocyte-macrophage colony-stimulating factor was mostly undetectable in samples obtained during both symptomatic and asymptomatic periods. Interleukin-5 levels were low, but tended to increase in samples from symptomatic children. These data confirm that the eosinophil product MBP and the eosinophil chemoattractant chemokines RANTES and macrophage inhibitory protein 1alpha are increased in upper respiratory viral infections associated with asthma exacerbations and suggest an important role for these chemokines in regulating eosinophil influx and activation. These chemokines may represent targets for therapeutic intervention in virus-induced asthma exacerbations. PMID- 9952376 TI - HLA-DQ alleles and human papillomavirus DNA in adult-onset laryngeal papillomatosis. AB - Sixty-two patients with histologically confirmed adult-onset laryngeal papilloma were clinically examined; their HLA class II DQA1 and DQB1 alleles and the presence and type of human papillomavirus (HPV) in their laryngeal papilloma biopsies were determined by polymerase chain reaction-based methods. No differences in the DQA1 or DQB1 frequencies appeared between the patients as a group and the reference population. When the patients were divided into groups according to number of laryngeal procedures performed, no HLA association was noticed with any group, nor did the presence of HPV-6 or HPV-11 DNA in the laryngeal specimen correlate with HLA type. A suggestive association was found between the DQB1 *0501 allele and the 16 patients whose laryngeal biopsy was HPV negative, but because of the small series, additional patients need to be studied. Earlier, the DQB1 *0501 allele was reported to be protective against cervical cancer, another HPV-associated disease. PMID- 9952377 TI - Infrequent detection of TT virus infection in intravenous drug users, prostitutes, and homosexual men. AB - TT virus (TTV), a recently discovered DNA virus, has been implicated as a cause of non-A to non-C posttransfusion hepatitis. The frequency of TTV in persons considered at high risk for sexual and parenteral infection was investigated (52 prostitutes, 81 homosexual men, 65 intravenous drug users) to assess its mode of transmission. TTV DNA was assayed by polymerase chain reaction using primers from conserved regions in the N22 clone. Viremia frequency was 4.5%-13.0% in study subjects, not significantly different from that in low-risk controls (2 [4.5%] of 44). The frequency of TTV viremia increased significantly with age (P=.018) but was not associated with human immunodeficiency virus coinfection. The low frequency of infection detected in both risk groups suggests that spread by sexual contact or by intravenous drug use is relatively inefficient and unlikely to account for the high prevalence of TTV observed worldwide. PMID- 9952378 TI - Cytomegalovirus infection and coronary heart disease: results of a german case control study. AB - This case-control study investigated whether previous infection with cytomegalovirus (CMV) was associated with coronary heart disease (CHD). In total, 312 patients of German nationality aged 40-68 years who had a coronary stenosis of >50% of the luminal diameter were recruited for study. Controls (n=479) were voluntary blood donors. CMV serology was performed to determine presence of specific CMV antibodies (IgG, IgM, IgA ELA test; Medac, Hamburg, Germany). Rheologic and inflammatory markers were determined. The prevalence of specific IgG antibodies against CMV was 54.5% in cases and 49.9% in controls (P=.116). The odds ratio for CHD was 1.21 (95% confidence interval, 0.84-1.75) given a positive serostatus of specific IgG antibodies after adjustment for covariates. With the exception of C-reactive protein in controls, none of the rheologic or inflammatory markers was associated with CMV serostatus. Thus, serologic evidence of previous infection with CMV was not a major risk factor for CHD in this population. PMID- 9952379 TI - Expression of granzyme B during primary cytomegalovirus infection after renal transplantation. AB - CD8+ T cells employ granzyme B (GrB) to induce apoptosis in target cells. Increased expression of GrB has been put forward as a diagnostic marker in transplant rejection and viral infection. Three-color flow cytometric analysis revealed that peripheral blood CD8+ T lymphocytosis during primary cytomegalovirus infection after renal transplantation resulted from expansion of a CD8+GrB+CD62L+ T cell subset that was almost absent during stable transplant function or acute rejection. This expansion coincided with a temporary increase in systemic soluble GrB (sGrB) levels. No such increase was observed during stable transplant function or acute rejection. Thus, the primary immune response to cytomegalovirus infection is accompanied by appearance of CD8+GrB+CD62L+ T cells and increased sGrB levels in the peripheral blood compartment. Determination of the latter may provide a novel approach for monitoring viral infections. PMID- 9952380 TI - Incidence of immune recovery vitritis in cytomegalovirus retinitis patients following institution of successful highly active antiretroviral therapy. AB - This study was conducted to determine the likelihood of the development of a new ocular inflammatory syndrome (immune recovery vitritis, IRV), which causes vision loss in AIDS patients with cytomegalovirus (CMV) retinitis, who respond to highly active antiretroviral therapy (HAART). We followed 30 HAART-responders with CD4 cell counts of >/=60 cells/mm3. Patients were diagnosed with IRV if they developed symptomatic vitritis of >/=1+ severity associated with inactive CMV retinitis. Symptomatic IRV developed in 19 (63%) of 30 patients and in 26 (59%) of 44 eyes over a median follow-up from HAART response of 13.5 months. The annual incidence of IRV was 83/100 person-years. Excluding patients with previous cidofovir therapy did not significantly alter the time course of IRV (P=.79). These data suggest that IRV develops in a significant number of HAART-responders with CMV retinitis and is unrelated to previous cidofovir therapy. PMID- 9952381 TI - Molluscum contagiosum virus: antibody responses in persons with clinical lesions and seroepidemiology in a representative Australian population. AB - An ELISA for molluscum contagiosum virus (MCV) was used to determine the antibody status of 35 adults with clinical infections and known human immunodeficiency virus (HIV) serology and of 357 persons (ages, 1 week-69 years) considered representative of the Australian population. MCV antibody was identified in 77% of persons with molluscum lesions: in 17 of 24 HIV-1-negative persons and in 10 of 11 who were HIV-1-positive. No relationship was evident between the serologic responses and the number of lesions or the duration of infection. The population survey revealed an overall seropositivity rate of 23%. The lowest antibody prevalence was in children aged 6 months to 2 years (3%), and seropositivity increased with age to reach 39% in persons >/=50 years old. These findings indicate that MCV infections, including very mild or subclinical cases, may be more common in the general community than previously suspected. PMID- 9952382 TI - Codon 215 mutations in human immunodeficiency virus-infected pregnant women. Swiss Collaborative 'HIV and Pregnancy' Study. AB - In 1994, the Pediatric AIDS Clinical Trials Group (PACTG) Protocol 076 demonstrated a two-thirds reduction of perinatal human immunodeficiency virus (HIV) type 1 transmission with zidovudine chemoprophylaxis. However, zidovudine alone does not fully suppress HIV replication, and chemoprophylaxis with zidovudine alone might select for zidovudine-resistant viral variants, decreasing the efficacy of zidovudine prophylaxis and affecting future responses to combined antiretroviral regimens. Sixty-two HIV-infected pregnant women consecutively enrolled in the ongoing Swiss HIV and Pregnancy Study were prospectively evaluated for the presence or development of zidovudine resistance by analysis of codon 215 of the reverse transcriptase gene. Six women (9.6%) harbored a codon T215Y/F mutation, which is associated with high-level resistance to zidovudine. Postnatal evaluation was completed in all children of mothers harboring the mutation. None was HIV-infected. The observed prevalence of codon 215 mutations of 9.6% raises important concerns regarding the future use of the PACTG 076 regimen. PMID- 9952383 TI - Antiviral activity of the human immunodeficiency virus type 1-specific nonnucleoside reverse transcriptase inhibitor HBY 097 alone and in combination with zidovudine in a phase II study. HBY 097/2001 Study Group. AB - The safety and antiviral activity of the second-generation nonnucleoside inhibitor HBY 097 was investigated in asymptomatic or mildly symptomatic human immunodeficiency virus (HIV)-1-infected patients in a randomized, double-blinded, dose-escalation study. Mean maximum virus load decreases ranged from -1.31 log10 copies/mL of plasma at week 1 in the group receiving HBY 097 monotherapy (250 mg three times daily) to -2.19 log10 copies/mL at week 4 in the group receiving zidovudine plus HBY 097 (750 mg three times daily). After 12 weeks, these patients had viral RNA copy numbers 1.05 log10 below baseline. Genotypic analysis of resistance development revealed reverse transcriptase K103N variants in most patients, which was associated with less durable efficacy of HBY 097 treatment. Fewer patients receiving combination therapy with high-dose HBY 097 developed the K103N variant (P<.01). HBY 097 caused pronounced acute suppression of HIV-1 replication both in combination with zidovudine and alone. Therefore, sustained antiviral activity can be expected from multiple combination therapy regimens including a quinoxaline derivative. PMID- 9952384 TI - LTB4 and LTC4 are absent in the cerebrospinal fluid of human immunodeficiency virus type 1-seropositive persons with toxoplasmic encephalitis: evidence for inhibition of 5-lipoxygenase by Toxoplasma gondii. AB - Previous studies on macrophages have shown that Toxoplasma gondii alters the metabolism of arachidonic acid with subsequent inability to generate leukotrienes (LT)s. LTB4 and LTC4 were analyzed in cerebrospinal fluid of 3 groups of human immunodeficiency virus (HIV) type 1-seropositive patients: with toxoplasmic encephalitis (TE) (n=10), with herpes simplex encephalitis (n=5), and without encephalitis (n=10) and in HIV-1-seronegative controls without inflammatory diseases (n=30) by specific immunoassays and gas chromatography-mass spectrometry. In HIV-1-seropositive subjects with TE, LTB4 and LTC4 were below the detection limit (<5.0 pg/mL) and thus significantly decreased (P<.01) compared with HIV-1-seropositive patients with herpes simplex encephalitis (LTB4, 148.5+/-47.6 pg/mL; LTC4, 116.4+/-36.9 pg/mL) and in those without encephalitis (LTB4, 46.1+/-16.8 pg/mL; LTC4, 48.3+/-21.3 pg/mL), and in controls (LTB4, 43.6+/ 21.2; LTC4, 45.2+/-18.9 pg/mL). These results point to an essential role of inhibition of 5-lipoxygenase with subsequent failure of LT release as an important mechanism for the survival of T. gondii in vivo. PMID- 9952385 TI - Combination antiretroviral therapy and recent declines in AIDS incidence and mortality. AB - The reasons for recent declines in AIDS incidence and mortality may include advances in treatment, but these may be confounded by earlier declines in the incidence of human immunodeficiency virus (HIV) infection. To determine whether the declines in AIDS and mortality may, in part, stem from wider use of combination antiretroviral therapy, 622 HIV-positive men with well-characterized dates of seroconversion were followed. In this group, combination therapy came into widespread use in only 1996. In a Cox proportional hazards model, the 1996 calendar period was significantly associated with slower progression to AIDS (relative hazard [RH]=0. 19, 95% confidence interval [CI], 0.05-0.69, P=.01) and death (RH=0. 45, 95% CI, 0.21-0.95, P=.04). Declines in incidence of HIV infection, changes in HIV virulence, and end-point underreporting cannot fully explain the decline in AIDS and death in 1996. The introduction of combination antiretroviral therapy as the standard of care may already have had measurable effects. PMID- 9952386 TI - Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene. AB - The active metabolite of vitamin D, 1,25 dihydroxyvitamin D3, is an important immunoregulatory hormone [1]. Its effects are exerted by interaction with the vitamin D receptor, which is present on human monocytes and activated T and B lymphocytes. Variation in the vitamin D receptor gene was typed in 2015 subjects from large case-control studies of three major infectious diseases: tuberculosis, malaria, and hepatitis B virus. Homozygotes for a polymorphism at codon 352 (genotype tt) were significantly underrepresented among those with tuberculosis (chi2=6.22, 1 df, P=. 01) and persistent hepatitis B infection (chi2=6.25, 1 df, P=.01) but not in subjects with clinical malaria compared with the other genotypes. Therefore, this genetic variant, which predisposes to low bone mineral density in many populations, may confer resistance to certain infectious diseases. PMID- 9952387 TI - Qualitative and quantitative analysis of the local and systemic antibody response in mice and humans with Helicobacter immunity and infection. AB - Immunization can prevent or cure an otherwise chronic gastric Helicobacter infection in several different animal models. The goal of the present study was to compare the titers and specificities of local and systemic antibody responses generated by Helicobacter infection and immunization. Protective immunization results in levels of specific gastric antibody significantly lower than induced by infection. However, antibodies from protectively immunized mice preferentially recognize immunodominant proteins of 10-22 and 30 kDa. Immunoblot analysis of infected mice and humans demonstrated that the serum IgA, but not serum IgG, binding profiles yield an accurate profile of the antigenic specificity of the host's gastric IgA. Therefore, serum IgA may be useful in evaluating the immunodominant antigens at the gastric mucosa of infected persons and possibly in determining the immunogenicity of orally applied Helicobacter vaccines. PMID- 9952388 TI - Correlates of gonococcal infection and of antimicrobial-resistant Neisseria gonorrhoeae among female sex workers, Republic of the Philippines, 1996-1997. AB - From 1994 to 1997, the proportion of Neisseria gonorrhoeae highly resistant to ciprofloxacin (MIC >/=4 microg/mL) increased substantially among female sex workers (FSWs) in the Philippines. Among 1499 Filipina FSWs, we evaluated factors associated with gonococcal infection and with gonococcal antimicrobial resistance. By multivariate analysis, gonococcal infection was associated with sex with a new client, self-prescribed prophylactic antimicrobial use, work in a brothel, and inconsistent condom use and was negatively associated with registration status and vaginal hygiene practices. Factors associated with ciprofloxacin-resistant gonococci included: marital status, living alone, duration of sex work, and clinic site. Further, gonococci highly resistant to ciprofloxacin were isolated from 10 (11.5%) of 87 FSWs reporting self-prescribed antimicrobial use versus 44 (3.4%) of 1295 reporting no antimicrobial use (P<.001). Self-prescribed prophylactic antimicrobial use and inconsistent condom use could be important factors in the continued emergence of gonococcal antimicrobial resistance in the Philippines. PMID- 9952389 TI - Selective anti-inflammatory action of interleukin-11 in murine Lyme disease: arthritis decreases while carditis persists. AB - The role of interleukin (IL)-11, a cytokine with potent anti-inflammatory properties, in murine Lyme disease was investigated. Borrelia burgdorferi infected mice treated with IL-11 developed less arthritis than did control animals. In contrast, IL-11 blocking antibodies increased Lyme arthritis. Murine Lyme carditis was not affected by either IL-11 or IL-11 antibodies. Administration of IL-11 was associated with increased production of mRNA for IL 12 and inducible nitric oxide synthase but not interferon-gamma or IL-4 in B. burgdorferi-infected mice, suggesting a predominant effect of IL-11 on the innate immune response. These data show that IL-11 selectively reduced joint but not cardiac inflammation caused by B. burgdorferi in mice. PMID- 9952390 TI - Eosinophil sequestration and activation are associated with the onset and severity of systemic adverse reactions following the treatment of onchocerciasis with ivermectin. AB - To investigate the role of eosinophil activation and sequestration in the development and severity of adverse reactions after the treatment of Onchocerca volvulus infection, 40 O. volvulus-infected Ghanaians were randomized to receive placebo or standard- or high-dose ivermectin. Subjects were examined for typical physiologic and clinical events before and up to 48 h after treatment. Plasma samples were tested for interleukin (IL)-5 and eosinophil degranulation products (e.g., eosinophil-derived neurotoxin, EDN). After treatment, peripheral eosinophil counts declined in ivermectin-treated groups (P<.001), whereas circulating levels of IL-5 (P<.01) and EDN (P<.05) increased. Cumulative levels of IL-5 and EDN correlated with reaction scores (P<.01). High-dose ivermectin was associated with more-severe reactions, more-profound eosinopenia, and higher circulating levels of IL-5 and EDN, compared with the standard dose. These results suggest that eosinophil sequestration and activation/degranulation are associated with the initiation and severity of ivermectin-associated adverse reactions. PMID- 9952391 TI - Increased levels of soluble interleukin-4 receptor in the sera of patients with visceral leishmaniasis. AB - Kenyan subjects with visceral leishmaniasis were examined for evidence of increased production of soluble interleukin-4 receptor (sIL-4R). Soluble IL-4R regulates the bioactivity of IL-4, a cytokine important in mediating progressive forms of leishmaniasis. Persons with visceral leishmaniasis sustained 8- to 10 fold more circulating sIL-4R compared with Papua New Guinea residents with documented filariasis or uninfected Kenyan and North American subjects. Soluble IL-2R concentrations were elevated nonspecifically in both visceral leishmaniasis and filariasis patients. These findings are significant given that IL-4 induces sIL-4R in mice, and treatment with recombinant sIL-4R cures progressive murine leishmaniasis dependent on IL-4 bioactivity. Further studies are indicated to determine whether the immunologic detection of IL-4 produced in human visceral leishmaniasis is obscured because of sequestration by soluble receptor and whether the production of sIL-4R is relevant to the pathogenesis of visceral leishmaniasis. PMID- 9952393 TI - Meningococcal disease outbreak associated with disco attendance. PMID- 9952392 TI - Plasma levels of the interleukin-6 cytokine family in persons with severe Plasmodium falciparum malaria. AB - Plasma levels of interleukin (IL)-6, soluble IL-6 receptor, soluble gp130, leukemia inhibitory factor (LIF), and ciliary neutrophic factor (CNTF) were analyzed in 32 patients with severe malaria. Ten had renal failure, 8 had cerebral malaria, and 14 had other causes of severity. Before treatment, the IL-6 and soluble IL-6 receptor plasma levels were significantly higher in persons with cerebral malaria or renal failure than in other groups (P<.01 for both). After initiation of therapy, IL-6 levels dropped within 24 h, but soluble IL-6 receptor levels increased. CNTF levels were significantly reduced in persons with cerebral malaria or renal failure but normalized within 24 h. Plasma concentrations of gp130 and LIF did not differ between the malaria groups or normal controls. Excessive levels of IL-6 could be controlled by a subsequent shedding of the soluble IL-6 receptor, and low-level CNTF expression could contribute to or even result from cerebral malaria or renal failure. PMID- 9952395 TI - Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+ dependent inactivation of NMDA receptors. AB - Glutamate receptors are associated with various regulatory and cytoskeletal proteins. However, an understanding of the functional significance of these interactions is still rudimentary. Studies in hippocampal neurons suggest that such interactions may be involved in calcium-induced reduction in the open probability of NMDA receptors (inactivation). Thus we examined the role of the intracellular domains of the NR1 subunit and two of its binding partners, calmodulin and alpha-actinin, on this process using NR1/NR2A heteromers expressed in human embryonic kidney (HEK) 293 cells. The presence of the first 30 residues of the intracellular C terminus of NR1 (C0 domain) was required for inactivation. Mutations in the last five residues of C0 reduced inactivation and produced parallel shifts in binding of alpha-actinin and Ca2+/calmodulin to the respective C0-derived peptides. Although calmodulin reduced channel activity in excised patches, calmodulin inhibitors did not block inactivation in whole-cell recording, suggesting that inactivation in the intact cell is more complex than binding of calmodulin to C0. Overexpression of putative Ca2+-insensitive, but not Ca2+-sensitive, forms of alpha-actinin reduced inactivation, an effect that was overcome by inclusion of calmodulin in the whole-cell pipette. The C0 domain also directly affects channel gating because NR1 subunits with truncated C0 domains that lacked calmodulin or alpha-actinin binding sites had a low open probability. We propose that inactivation can occur after C0 dissociates from alpha-actinin by two distinct but converging calcium-dependent processes: competitive displacement of alpha-actinin by calmodulin and reduction in the affinity of alpha-actinin for C0 after binding of calcium to alpha-actinin. PMID- 9952396 TI - Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways. AB - We have shown that estrogen elicits a selective enhancement of the growth and differentiation of axons and dendrites (neurites) in the developing CNS. We subsequently demonstrated widespread colocalization of estrogen and neurotrophin receptors (trk) within developing forebrain neurons and reciprocal transcriptional regulation of these receptors by their ligands. Using organotypic explants of the cerebral cortex, we tested the hypothesis that estrogen/neurotrophin receptor coexpression also may result in convergence or cross-coupling of their signaling pathways. Estradiol elicited rapid (within 5-15 min) tyrosine phosphorylation/activation of the mitogen-activated protein (MAP) kinases, ERK1 and ERK2, that persisted for at least 2 hr. This extracellular signal-regulated protein kinase (ERK) activation was inhibited successfully by the MEK1 inhibitor PD98059, but not by the estrogen receptor (ER) antagonist ICI 182,780, and did not appear to result from estradiol-induced activation of trk. Furthermore, we also found that estradiol elicited an increase in B-Raf kinase activity. The latter and subsequent downstream events leading to ERK activation may be a consequence of our documentation of a multimeric complex consisting of, at least, the ER, hsp90, and B-Raf. These novel findings provide an alternative mechanism for some of the estrogen actions in the developing CNS and could explain not only some of the very rapid effects of estrogen but also the ability of estrogen and neurotrophins to regulate the same broad array of cytoskeletal and growth-associated genes involved in neurite growth and differentiation. PMID- 9952397 TI - Cellular localization of huntingtin in striatal and cortical neurons in rats: lack of correlation with neuronal vulnerability in Huntington's disease. AB - Immunohistochemistry and single-cell RT-PCR were used to characterize the localization of huntingtin and/or its mRNA in the major types of striatal neurons and in corticostriatal projection neurons in rats. Single-label immunohistochemical studies revealed that striatum contains scattered large neurons rich in huntingtin and more numerous medium-sized neurons moderate in huntingtin. Double-label immunohistochemical studies showed that the large huntingtin-rich striatal neurons include nearly all cholinergic interneurons and some parvalbuminergic interneurons. Somatostatinergic striatal interneurons, which are medium in size, rarely contained huntingtin. Calbindin immunolabeling showed that the vast majority of the medium-sized striatal neurons that contain huntingtin are projection neurons, but only approximately 65% of calbindin labeled projection neurons (localized to the matrix compartment of striatum) were labeled for huntingtin. Calbindin-containing projection neurons of the matrix compartment and calbindin-negative projection neurons of the striatal patch compartment contained huntingtin with comparable frequency. Single-cell RT-PCR confirmed that striatal cholinergic interneurons contain huntingtin, but only approximately 65% of projection neurons contained detectable huntingtin message. The finding that huntingtin is not consistently found in striatal projection neurons [which die in Huntington's disease (HD)] but is abundant in striatal cholinergic interneurons (which survive in Huntington's disease) suggests that the mutation in huntingtin that causes HD may not directly kill neurons. In contrast to the heterogeneous expression of huntingtin in the different striatal neuron types, we found all corticostriatal neurons to be rich in huntingtin protein and mRNA. One possibility raised by our findings is that the HD mutation may render corticostriatal neurons destructive rather than render striatal neurons vulnerable. PMID- 9952398 TI - The photovoltage of macaque cone photoreceptors: adaptation, noise, and kinetics. AB - Whole-cell voltage and current recordings were obtained from red and green cone photoreceptors in isolated retina from macaque monkey. It was demonstrated previously that the cone photovoltage is generated from two sources, phototransduction current in the cone outer segment and photocurrent from neighboring rods. Rod signals are likely transmitted to cones across the gap junctions between rods and cones. In this study, the "pure" cone and rod components of the response were extracted with rod-adapting backgrounds or by subtracting the responses to flashes of different wavelength equated in their excitation of either rods or cones. For dim flashes, the pure cone component was similar in waveform to the cone outer segment current, and the rod component was similar to the photovoltage measured directly in rods. With bright flashes, the high frequencies of the rod signal were filtered out by the rod/cone network. The two components of the cone photovoltage adapted separately to background illumination. The amplitude of the rod component was halved by backgrounds eliciting approximately 100 photoisomerizations sec-1 per rod; the cone component was halved by backgrounds of 8700 photoisomerizations sec-1 per cone. Coupling between rods and cones was not modulated by either dim backgrounds or dopamine. Voltage noise in dark-adapted cones was dominated by elementary events other than photopigment isomerizations. The dark noise was equivalent in magnitude to a steady light eliciting approximately 3800 photoisomerizations sec-1 per cone, a value significantly higher than the psychophysical estimates of cone "dark light." PMID- 9952399 TI - Uptake of precursor and synthesis of transmitter in a histaminergic photoreceptor. AB - As a first step in understanding how the supply of the neurotransmitter histamine is maintained in a photoreceptor, we followed the uptake and metabolism of the immediate precursor of histamine, histidine. [3H]Histidine taken up into photoreceptors and glia was detected using autoradiography, and synthesis of [3H]histamine from [3H]histidine was assayed with thin-layer chromatography. Photoreceptors from barnacles were pulsed (15 min) with [3H]histidine (0.2-200 microM), then maintained in normal saline for up to 24 hr. Autoradiography showed that photoreceptor somata, axons, and presynaptic arbors were labeled, but only weakly, like (nonhistaminergic) ganglion cells. Label instead was concentrated over surrounding glia. Stimulating preparations with light did not increase photoreceptor labeling. Grain counts from photoreceptor axons showed uptake of [3H]histidine into these neurons by a Na+-dependent mechanism with a Km of approximately 50 microM. Over 24 hr only 1% of the [3H]histidine taken up by preparations was converted to [3H]histamine either in the dark or in the light. Injections of [3H]histidine directly into photoreceptors established that synthesis takes place within the photoreceptors and confirmed that stimulation with light did not measurably affect the rate of conversion of [3H]histidine to [3H]histamine. These results suggest that de novo synthesis of transmitter is unlikely to be as important as its reuptake in maintaining neurotransmitter supply in these photoreceptor terminals. In support of this conclusion, photoreceptors accumulated more label when transmitter release was stimulated with high K+ and histamine uptake was antagonized with chlorpromazine. PMID- 9952401 TI - Hippocampal long-term potentiation preserves the fidelity of postsynaptic responses to presynaptic bursts. AB - Hippocampal cells often fire prolonged bursts of action potentials, resulting in dynamic modulation of postsynaptic responses; yet long-term potentiation (LTP) has routinely been studied using only single presynaptic stimuli given at low frequency. Recent work on neocortical synapses has suggested that LTP may cause a "redistribution of synaptic strength" in which synaptic responses to the first stimulus of a presynaptic burst of action potentials are potentiated with later responses depressed. We have examined whether this redistribution occurs at hippocampal synapses during LTP. Using prolonged bursts that result in maximal short-term depression of later responses within the burst, we found that LTP resulted in a uniform potentiation of individual responses throughout the burst rather than a redistribution of synaptic strength. This occurred both at Schaffer collateral-CA1 synapses and at CA3-CA3 synapses, the latter being activated and monitored using paired recordings. Thus in the hippocampus, LTP preserves the fidelity of postsynaptic responses to presynaptic bursts by a uniform increase rather than a redistribution of synaptic strength, a finding that suggests there are important differences between neocortex and hippocampus in how long-term changes in synaptic strength are used to encode new information. PMID- 9952400 TI - Reg1ulatory role and molecular interactions of a cell-surface heparan sulfate proteoglycan (N-syndecan) in hippocampal long-term potentiation. AB - The cellular mechanisms responsible for synaptic plasticity involve interactions between neurons and the extracellular matrix. Heparan sulfates (HSs) constitute a group of glycosaminoglycans that accumulate in the beta-amyloid deposits in Alzheimer's disease and influence the development of neuron-target contacts by interacting with other cell surface and matrix molecules. However, the contribution of HSs to brain function is unknown. We found that HSs play a crucial role in long-term potentiation (LTP), a finding that is consistent with the idea that converging molecular mechanisms are used in the development of neuron-target contacts and in activity-induced synaptic plasticity in adults. Enzymatic cleavage of HS by heparitinase as well as addition of soluble heparin type carbohydrates prevented expression of LTP in response to 100 Hz/1 sec stimulation of Schaffer collaterals in rat hippocampal slices. A prominent carrier protein for the type of glycans implicated in LTP regulation in the adult hippocampus was identified as N-syndecan (syndecan-3), a transmembrane proteoglycan that was expressed at the processes of the CA1 pyramidal neurons in an activity-dependent manner. Addition of soluble N-syndecan into the CA1 dendritic area prevented tetanus-induced LTP. A major substrate of src-type kinases, cortactin (p80/85), and the tyrosine kinase fyn copurified with N syndecan from hippocampus. Moreover, association of both cortactin and fyn to N syndecan was rapidly increased after induction of LTP. N-syndecan may thus act as an important regulator in the activity-dependent modulation of neuronal connectivity by transmitting signals between extracellular heparin-binding factors and the fyn signaling pathway. PMID- 9952402 TI - Activation of protein kinase A contributes to the expression but not the induction of long-term hyperexcitability caused by axotomy of Aplysia sensory neurons. AB - Nociceptive sensory neurons (SNs) in Aplysia provide useful models to study both memory and adaptive responses to nerve injury. Induction of long-term memory in many species, including Aplysia, is thought to depend on activation of cAMP dependent protein kinase (PKA). Because Aplysia SNs display similar alterations in models of memory and after nerve injury, a plausible hypothesis is that axotomy triggers memory-like modifications by activating PKA in damaged axons. The present study disproves this hypothesis. SN axotomy was produced by (1) dissociation of somata from the ganglion [which is shown to induce long-term hyperexcitability (LTH)], (2) transection of neurites of dissociated SNs growing in vitro, or (3) peripheral nerve crush. Application of the competitive PKA inhibitor Rp-8-CPT-cAMPS at the time of axotomy failed to alter the induction of LTH by each form of axotomy, although the inhibitor antagonized hyperexcitability produced by 5-HT application. Strong activation of PKA in the nerve by coapplication of a membrane-permeant analog of cAMP and a phosphodiesterase inhibitor was not sufficient to induce LTH of either the SN somata or axons. Furthermore, nerve crush failed to activate axonal PKA or stimulate its retrograde transport. Therefore, PKA activation plays little if any role in the induction of LTH by axotomy. However, the expression of LTH was reduced by intracellular injection of the highly specific PKA inhibitor PKI several days after nerve crush. This suggests that long-lasting activation of PKA in or near the soma contributes to the maintenance of long-term modifications produced by nerve injury. PMID- 9952403 TI - Ciliary neurotrophic factor is a regulator of muscular strength in aging. AB - Ciliary neurotrophic factor (CNTF) participates in the survival of motor neurons and reduces the denervation-induced atrophy of skeletal muscles. Experiments performed in rats show a decrease in peripheral CNTF synthesis during aging, associated with an overexpression of its alpha-binding receptor component by skeletal muscles. Measurement of sciatic nerve CNTF production and of the muscular performance developed by the animals revealed a strong correlation between the two studied parameters (r = 0.8; p < 0.0003). Furthermore, the twitch and tetanic tensions measured in the isolated soleus skeletal muscle in 24-month old animals increased 2. 5-fold by continuous in vivo administration of CNTF. Analyses of the activation level of leukemia inhibitory factor receptor beta- and signal transducer and activator of transcription 3-signaling molecules in response to exogenous CNTF revealed an increased tyrosine phosphorylation positively correlated with the twitch tension developed by the soleus muscle of the animals. PMID- 9952404 TI - Rapid, activation-induced redistribution of ionotropic glutamate receptors in cultured hippocampal neurons. AB - We have examined the membrane localization of an AMPA receptor subunit (GluR1) and an NMDA receptor subunit (NR1) endogenously expressed in primary cultures of rat hippocampal neurons. In unstimulated cultures, both GluR1 and NR1 subunits were concentrated in SV2-positive synaptic clusters associated with dendritic shafts and spines. Within 5 min after the addition of 100 microM glutamate to the culture medium, a rapid and selective redistribution of GluR1 subunits away from a subset of synaptic sites was observed. This redistribution of GluR1 subunits was also induced by AMPA, did not require NMDA receptor activation, did not result from ligand-induced neurotoxicity, and was reversible after the removal of agonist. The activation-induced redistribution of GluR1 subunits was associated with a pronounced (approximately 50%) decrease in the frequency of miniature EPSCs, consistent with a role of GluR1 subunit redistribution in mediating rapid regulation of synaptic efficacy. We conclude that ionotropic glutamate receptors are regulated in native neurons by rapid, subtype-specific membrane trafficking, which may modulate synaptic transmission in response to physiological or pathophysiological activation. PMID- 9952405 TI - Mutation in neurofilament transgene implicates RNA processing in the pathogenesis of neurodegenerative disease. AB - A mouse neurofilament light subunit (NF-L) transgene with a 36 bp c-myc insert at the end of the coding region was found to have neuropathic effects on enteric and motor neurons of transgenic mice. The severity of phenotype was related directly to the levels of transgenic mRNA expression. High levels of transgene expression were lethal to newborn pups, causing profound alterations in the development of the enteric nervous system and extensive vacuolar changes in motor neurons. Lower levels of transgene expression led to a transient stunting of growth and focal alterations of enteric and motor neurons. Because the positioning of the c-myc insert coincided with the location of the major stability determinant of the NF-L mRNA (Canete-Soler et al., 1998a,b), additional studies were undertaken. These studies showed that the c-myc insert alters the ribonucleoprotein (RNP) complexes that bind to the stability determinant and disrupts their ability to regulate the stability of the transcripts. The findings indicate that expression of an NF-L transgene with a mutant mRNA stability determinant is highly disruptive to enteric and motor neurons and implicate alterations in RNA processing in the pathogenesis of a neurodegenerative condition. PMID- 9952407 TI - Sustained and accelerating activity at two discrete sites generate epileptiform discharges in slices of piriform cortex. AB - When near-threshold electrical stimulation is used to evoke epileptiform discharges in brain slices, a latent period of up to 150 msec elapses before the discharge begins. During this period most neurons are silent, and abnormal electrical activity is difficult to detect with microelectrodes. A fundamental question about epileptiform activity concerns how synchronous discharges arise abruptly in a relatively quiescent slice. This issue was addressed here by using voltage imaging techniques to study epileptiform discharges in rat piriform cortex slices. These experiments revealed two distinct forms of electrical activity during the latent period. (1) A steeply increasing depolarization, referred to here as onset activity, has been described previously and occurs at the site of discharge onset. (2) A sustained depolarization that precedes onset activity, referred to here as plateau activity, has not been described previously. Plateau and onset activity occurred in different subregions of the endopiriform nucleus (a region of high seizure susceptibility). When cobalt or kynurenic acid was applied focally to inhibit electrical activity at the site of plateau activity, discharges were blocked. However, application of these agents to other nearby sites (except the site of onset) failed to block discharges. Plateau activity represents a novel form of electrical activity that precedes and is necessary for epileptiform discharges. Discharges thus are generated in a sequential process by two spatially distinct neuronal circuits. The first circuit amplifies and sustains activity initiated by the stimulus, and the second generates the actual discharge in response to an excitatory drive from the first. PMID- 9952406 TI - Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. AB - Oxidative stress is thought to contribute to dopaminergic cell death in Parkinson's disease (PD). The neurotoxin 6-hydroxydopamine (6-OHDA), which is easily oxidized to reactive oxygen species (ROS), appears to induce neuronal death by a free radical-mediated mechanism, whereas the involvement of free radicals in N-methyl-4-phenylpyridinium (MPP+) toxicity is less clear. Using free radical-sensitive fluorophores and vital dyes with post hoc identification of tyrosine hydroxylase-positive neurons, we monitored markers of apoptosis and the production of ROS in dopaminergic neurons treated with either 6-OHDA or MPP+. Annexin-V staining suggested that 6-OHDA but not MPP+-mediated cell death was apoptotic. In accordance with this assignment, the general caspase inhibitor Boc (Asp)-fluoromethylketone only blocked 6-OHDA neurotoxicity. Both toxins exhibited an early, sustained rise in ROS, although only 6-OHDA induced a collapse in mitochondrial membrane potential temporally related to the increase in ROS. Recently, derivatives of buckminsterfullerene (C60) molecules have been shown to act as potent antioxidants in several models of oxidative stress (Dugan et al., 1997). Significant, dose-dependent levels of protection were also seen in these in vitro models of PD using the C3 carboxyfullerene derivative. Specifically, C3 was fully protective in the 6-OHDA paradigm, whereas it only partially rescued dopaminergic neurons from MPP+-induced cell death. In either model, it was more effective than glial-derived neurotrophic factor. These data suggest that cell death in response to 6-OHDA and MPP+ may progress through different mechanisms, which can be partially or entirely saved by carboxyfullerenes. PMID- 9952408 TI - Molecular analysis of the X11-mLin-2/CASK complex in brain. AB - A heterotrimeric complex containing Lin-10/X11alpha, Lin-2/CASK, and Lin-7 is evolutionarily conserved from worms to mammals. In Caenorhabditis elegans, it localizes Let-23, a receptor tyrosine kinase, to the basolateral side of vulval epithelium, a step crucial for proper vulva development. In mammals, the complex may also participate in receptor targeting in neurons. Accordingly, phosphotyrosine binding (PTB) and postsynaptic density-95/Discs large/Zona Occludens-1 domains found in X11alpha and mLin-2/CASK bind to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. In this paper, we have further analyzed the X11alpha-mLin-2/CASK association that is mediated by a novel protein-protein interaction. We show that the mLin-2/CASK calmodulin kinase II (CKII) domain directly binds to a 63 amino acids peptide located between the Munc-18-1 binding site and the PTB domain in X11alpha. Ca2+/calmodulin association with mLin-2/CASK does not modify the X11alpha-mLin-2 interaction. A region containing the mLin-2/CASK guanylate kinase domain also interacts with X11alpha but with a lower affinity than the CKII domain. Immunostaining of X11alpha in the brain shows that the protein is expressed in areas shown previously to be positive for mLin-2/CASK staining. Together, our data demonstrate that the X11alpha-mLin-2 complex contacts many partners, creating a macrocomplex suitable for receptor targeting at the neuronal plasma membrane. PMID- 9952409 TI - Inhibitors of myosin light chain kinase block synaptic vesicle pool mobilization during action potential firing. AB - During repetitive action potential firing the maintenance of synaptic transmission relies on a continued supply of synaptic vesicles for fusion with the presynaptic plasma membrane. The mechanism of transport by which vesicles are delivered to the site of fusion from a reserve pool is unknown, as are the biochemical pathways linking intracellular Ca2+ elevation with vesicle mobilization. Here, using the fluorescent tracer FM1-43 in hippocampal synaptic terminals, I show that inhibitors of myosin light chain kinase can block mobilization of the reserve pool and not the immediately releasable pool. PMID- 9952410 TI - The sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains. AB - The molecules that specify domains on the neuronal plasma membrane for the delivery and accumulation of vesicles during neurite outgrowth and synapse formation are unknown. We investigated the role of the sec6/8 complex, a set of proteins that specifies vesicle targeting sites in yeast and epithelial cells, in neuronal membrane trafficking. This complex was found in layers of developing rat brain undergoing synaptogenesis. In cultured hippocampal neurons, the sec6/8 complex was present in regions of ongoing membrane addition: the tips of growing neurites, filopodia, and growth cones. In young axons, the sec6/8 complex was also confined to periodic domains of the plasma membrane. The distribution of synaptotagmin, synapsin1, sec6, and FM1-43 labeling in cultured neurons suggested that the plasma membrane localization of the sec6/8 complex preceded the arrival of synaptic markers and was downregulated in mature synapses. We propose that the sec6/8 complex specifies sites for targeting vesicles at domains of neurite outgrowth and potential active zones during synaptogenesis. PMID- 9952411 TI - Suppression of postischemic hippocampal nerve growth factor expression by a c-fos antisense oligodeoxynucleotide. AB - We examined the uptake and distribution of an antisense phosphorothioated oligodeoxynucleotide (s-ODN) to c-fos, rncfosr115, infused into the left cerebral ventricle of male Long-Evans rats and the effect of this s-ODN on subsequent Fos, NGF, neurotrophin-3 (NT-3), and actin expression. To establish the uptake and turnover of s-ODN in the brain, we studied the copurification of the immunoreactivity of biotin with biotinylated s-ODN that was recovered from different regions of the brain. A time-dependent diffusion and the localization of s-ODN were further demonstrated by labeling the 3'-OH terminus of s-ODN in situ with digoxigenin-dUTP using terminal transferase and detection using anti digoxigenin IgG-FITC. Cellular uptake of the s-ODN was evident in both the hippocampal and cortical regions, consistent with a gradient originating at the ventricular surface. Degradation of the s-ODN was observed beginning 48 hr after delivery. The effectiveness of c-fos antisense s-ODN was demonstrated by its suppression of postischemic Fos expression, which was accompanied by an inhibition of ischemia-induced NGF mRNA expression in the dentate gyrus. Infusion of saline, the sense s-ODN, or a mismatch antisense s-ODN did not suppress Fos expression. That this effect of c-fos antisense s-ODN was specific to NGF was demonstrated by its lack of effect on the postischemic expression of the NT-3 and beta-actin genes. Our results demonstrate that c-fos antisense s-ODN blocks selected downstream events and support the contention that postischemic Fos regulates the subsequent expression of the NGF gene and that Fos expression may have a functional component in neuroregeneration after focal cerebral ischemia reperfusion. PMID- 9952412 TI - Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections. AB - Here we examine the role of Reelin, an extracellular protein involved in neuronal migration, in the formation of hippocampal connections. Both at prenatal and postnatal stages, the general laminar and topographic distribution of entorhinal projections is preserved in the hippocampus of reeler mutant mice, in the absence of Reelin. However, developing and adult entorhinal afferents show severe alterations, including increased numbers of misrouted fibers and the formation of abnormal patches of termination from the medial and lateral entorhinal cortices. At perinatal stages, single entorhinal axons in reeler mice are grouped into thick bundles, and they have decreased axonal branching and decreased extension of axon collaterals. We also show that the number of entorhino-hippocampal synapses is lower in reeler mice than in control animals during development. Studies performed in mixed entorhino-hippocampal co-cultures combining slices from reeler and wild-type mice indicate that these abnormalities are caused by the lack of Reelin in the target hippocampus. These findings imply that Reelin fulfills a modulatory role during the formation of layer-specific and topographic connections in the hippocampus. They also suggest that Reelin promotes maturation of single fibers and synaptogenesis by entorhinal afferents. PMID- 9952413 TI - Odor-induced, activity-dependent transneuronal gene induction in vitro: mediation by NMDA receptors. AB - Expression of tyrosine hydroxylase (TH) by juxtaglomerular (JG) neurons of the olfactory bulb (OB) requires innervation of the bulb by olfactory receptor neurons (ORNs). ORN lesion selectively downregulates TH in JG neurons. In reversible odor deprivation, TH expression is downregulated as the naris is closed and then upregulated upon naris reopening. The mechanism or mechanisms regulating this dependence are unknown. TH expression could be regulated by trophic factor release and/or synaptic activity from ORN terminals. We investigated TH expression in cocultures of dissociated postnatal rat OB cells and embryonic olfactory neuroepithelium (OE) slice explants. TH-positive neurons in control dissociated OB cell cultures alone comprise only a small fraction of the total population of cells present in the culture. However, when OE slice explants are cocultured with dispersed OB cells, there is a mean 2.4-fold increase in the number of TH-positive neurons. ORNs in vivo use glutamate as a neurotransmitter. Broad spectrum excitatory amino acid antagonists (kyurenic acid) or selective antagonists of the NMDA receptor (APV) both prevent induction of TH expression in OE-OB cocultures. Furthermore, pulse application of NMDA stimulates TH expression in OB neurons in the absence of OE. In vitro, OB TH neurons express NMDA receptors, suggesting that NMDA stimulation is acting directly on TH neurons. Exposure of OE explants to natural odorants results in upregulation of TH, presumably through increased ORN activity, which could be blocked by APV. These findings indicate that odorant-stimulated glutamate release by ORN terminals regulates TH expression via NMDA receptors on JG dopaminergic neurons. PMID- 9952414 TI - Lysophosphatidic acid stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts. AB - During neurogenesis in the embryonic cerebral cortex, the classical neurotransmitters GABA and L-glutamate stimulate ionic conductance changes in ventricular zone (VZ) neuroblasts. Lysophosphatidic acid (LPA) is a bioactive phospholipid producing myriad effects on cells including alterations in membrane conductances (for review, see Moolenaar et al., 1995). Developmental expression patterns of its first cloned receptor gene, lpA1/vzg-1 (Hecht et al., 1996; Fukushima et al., 1998) in the VZ suggested that functional LPA receptors were synthesized at these early times, and thus, LPA could be an earlier stimulus to VZ cells than the neurotransmitters GABA and L-glutamate. To address this possibility, primary cultures of electrically coupled, presumptive cortical neuroblast clusters were identified by age, morphology, electrophysiological profile, BrdU incorporation, and nestin immunostaining. Single cells from cortical neuroblast cell lines were also examined. Whole-cell variation of the patch-clamp technique was used to record from nestin-immunoreactive cells after stimulation by local administration of ligands. After initial plating at embryonic day 11 (E11), cells responded only to LPA but not to GABA or L glutamate. Continued growth in culture for up to 12 hr produced more LPA responsive cells, but also a growing population of GABA- or L-glutamate responsive cells. Cultures from E12 embryos showed LPA as well as GABA and L glutamate responses, with LPA-responsive cells still representing a majority. Overall, >50% of cells responded to LPA with depolarization mediated by either chloride or nonselective cation conductances. These data implicate LPA as the earliest reported extracellular stimulus of ionic conductance changes for cortical neuroblasts and provide evidence for LPA as a novel, physiological component in CNS development. PMID- 9952415 TI - BEN/SC1/DM-GRASP expression during neuromuscular development: a cell adhesion molecule regulated by innervation. AB - BEN/SC1/DM-GRASP is a cell adhesion molecule belonging to the Ig superfamily that is transiently expressed during avian embryogenesis in a variety of cell types, including the motoneurons of the spinal cord. We have investigated the pattern of BEN expression during neuromuscular development of the chick. We show that both motoneurons and their target myoblasts express BEN during early embryonic development and that the protein becomes restricted at neuromuscular contacts as soon as postsynaptic acetylcholine receptor clusters are observed in muscle fibers. Muscle cells grown in vitro express and maintain BEN expression even when they fuse and give rise to mature myotubes. When embryos are deprived of innervation by neural tube ablation, BEN expression is observed in muscle fibers, whereas, in control, the protein is already restricted at neuromuscular synaptic sites. These results demonstrate that all myogenic cells intrinsically express BEN and maintain the protein in the absence of innervation. Conversely, when neurons are added to myogenic cultures, BEN is rapidly downregulated in muscle cells, demonstrating that innervation controls the restricted pattern of BEN expression seen in innervated muscles. After nerve section in postnatal muscles, BEN protein becomes again widely spread over muscle fibers. When denervated muscles are allowed to be reinnervated, the protein is reexpressed in regenerating motor axons, and reinnervation of synaptic sites leads to the concentration of BEN at neuromuscular junctions. Our results suggest that BEN cell adhesion molecule acts both in the formation of neuromuscular contacts during development and in the events leading to muscle reinnervation. PMID- 9952416 TI - Stimulation of myelin basic protein gene transcription by Fyn tyrosine kinase for myelination. AB - Myelin is synthesized about the time of birth. The Src-family tyrosine kinase Fyn is involved in the initial events of myelination. Fyn is present in myelin forming cells and is activated through stimulation of cell surface receptors such as large myelin-associated glycoprotein (L-MAG). Here we show that Fyn stimulates transcription of the myelin basic protein (MBP) gene for myelination. MBP is a major component of the myelin membrane. In 4-week-old Fyn-deficient mice, MBP is significantly reduced, and electron microscopic analysis showed that myelination is delayed, compared with wild-type mice. The Fyn-deficient mice had thinner, more irregular myelin than the wild-type. We found that Fyn stimulates the promoter activity of the MBP gene by approximately sevenfold. The region responsible for the transactivation by Fyn is located between nucleotides -675 and -647 with respect to the transcription start site. Proteins binding to this region were found by gel shift study, and the binding activity correlates with Fyn activity during myelination. These results suggest that transactivation of the MBP gene by Fyn is important for myelination. PMID- 9952417 TI - Organization of disparity-selective neurons in macaque area MT. AB - Neurons selective for binocular disparity are found in a number of visual cortical areas in primates, but there is little evidence that any of these areas are specialized for disparity processing. We have examined the organization of disparity-selective neurons in the middle temporal visual area (MT), an area shown previously to contain an abundance of disparity-sensitive neurons. We recorded extracellularly from MT neurons at regularly spaced intervals along electrode penetrations that passed through MT either normal to the cortical surface or at a shallow oblique angle. Comparison of multiunit and single-unit recordings shows that neurons are clustered in MT according to their disparity selectivity. Across the surface of MT, disparity-selective neurons are found in discrete patches that are separated by regions of MT that exhibit poor disparity tuning. Within disparity-selective patches of MT, we typically observe a smooth progression of preferred disparities (e.g. , near to far) as our electrode travels parallel to the cortical surface. In electrode penetrations normal to the cortical surface, on the other hand, MT neurons generally have similar disparity tuning, with little variation from one recording site to the next. Thus disparity tuned neurons are organized into cortical columns by preferred disparity, and preferred disparity is mapped systematically within larger, disparity-tuned patches of MT. Combined with other recent findings, the data suggest that MT plays an important role in stereoscopic depth perception in addition to its well known role in motion perception. PMID- 9952418 TI - GDNF protection against 6-OHDA-induced reductions in potassium-evoked overflow of striatal dopamine. AB - Glial cell line-derived neurotrophic factor (GDNF), when administered before 6 hydroxydopamine (6-OHDA), has been shown to prevent the reduction in nigral dopamine (DA) levels and tyrosine hydroxylase-positive neurons normally observed after 6-OHDA lesions. The present study examined the ability of GDNF to prevent 6 OHDA-induced reductions in striatal DA release and reductions in striatal and nigral DA levels. GDNF (10 micrograms), or vehicle, was injected into the right nigra of anesthetized male Fischer-344 rats and was followed 6 hr later by intranigral 6-OHDA or saline. Three to four weeks later the animals were anesthetized with urethane and prepared for in vivo electrochemistry. Potassium evoked overflow of DA was dramatically decreased in the right striatum of the vehicle + 6-OHDA-treated animals. GDNF appeared to prevent the reduction in evoked overflow of DA in the right striatum of the 6-OHDA-treated animals. However, in comparison with that in animals that received GDNF + saline, the overflow of DA was significantly reduced in the GDNF + 6-OHDA animals. Similarly, although nigral levels of DA were above normal in the GDNF + 6-OHDA-treated animals, they were below DA levels found in GDNF + saline-treated rats. Striatal DA levels were partially protected by GDNF. In animals examined 10-12 weeks after the GDNF and 6-OHDA treatments, the apparent protective ability of GDNF on the evoked overflow of DA in the striatum was diminished. Thus, although intranigral GDNF can prevent 6-OHDA-induced reductions in nigral DA levels, long-term protection of the evoked overflow of DA in the striatum is minimal. PMID- 9952419 TI - Selective inhibition of kindling development by intraventricular administration of TrkB receptor body. AB - Recent work has shown that neurotrophin gene expression is increased after seizures evoked in the kindling model of epilepsy, but whether neurotrophins regulate kindling development is as yet unclear. In this study, we attempted to block selectively the activation of distinct neurotrophin receptors throughout kindling development in the rat via chronic intracerebroventricular administration of trk receptor bodies. The efficacy and selectivity of the trk receptor bodies were established by inhibition of neurotrophin-induced trk receptor phosphorylation in pheochromocytoma (PC12) cells and primary cultures of cortical neurons. The intracerebroventricular infusion of trkB receptor body (trkB-Fc) inhibited development of kindling in comparison with that seen with saline or human IgG controls, trkA-Fc, or trkC-Fc. These results imply that activation of trkB receptors contributes to the development of kindling, a form of activity-dependent behavioral plasticity in the adult mammalian brain. PMID- 9952420 TI - Dopamine selectively inhibits the direct cortical pathway to the CA1 hippocampal region. AB - The perforant path input (pp) is a major direct source of specific sensory information for the CA1 hippocampal region. The termination area of this pathway, the stratum lacunosum-moleculare, has the highest concentration of dopamine receptors in the hippocampus. We have examined the properties of the pp input and its modulation by dopamine. The input is glutamatergic and has a larger NMDA component than the Schaffer collateral (sc) input. Dopamine strongly inhibits the response to pp stimulation (IC50 approximately 3 microM) but not the response to sc stimulation. Dopamine reduces both the NMDA and AMPA components of transmission at the pp and increases paired-pulse facilitation. In the sc, the NMDA component but not the AMPA component is decreased, and paired-pulse facilitation is not affected. The effect of dopamine on the pp does not depend on GABAA inhibition but is reduced by the antagonists of both D1 and D2 families of dopamine receptors. The effect is not completely blocked by the combination of D1 and D2 antagonists, but is completely blocked by the atypical neuroleptic clozapine. Our results provide the first evidence for strong dopaminergic control of transmission in the perforant path. By inhibiting this pathway, dopamine hyperfunction and/or NMDA hypofunction abnormalities implicated in schizophrenia may isolate CA1 from its main source of sensory information. PMID- 9952421 TI - The organization of cerebellar and basal ganglia outputs to primary motor cortex as revealed by retrograde transneuronal transport of herpes simplex virus type 1. AB - We used retrograde transneuronal transport of herpes simplex virus type 1 to map the origin of cerebellar and basal ganglia "projections" to leg, arm, and face areas of the primary motor cortex (M1). Four to five days after virus injections into M1, we observed many densely labeled neurons in localized regions of the output nuclei of the cerebellum and basal ganglia. The largest numbers of these neurons were found in portions of the dentate nucleus and the internal segment of the globus pallidus (GPi). Smaller numbers of labeled neurons were found in portions of the interpositus nucleus and the substantia nigra pars reticulata. The distribution of neuronal labeling varied with the cortical injection site. For example, within the dentate, neurons labeled from leg M1 were located rostrally, those from face M1 caudally, and those from arm M1 at intermediate levels. In each instance, labeled neurons were confined to approximately the dorsal third of the nucleus. Within GPi, neurons labeled from leg M1 were located in dorsal and medial regions, those from face M1 in ventral and lateral regions, and those from arm M1 in intermediate regions. These results demonstrate that M1 is the target of somatotopically organized outputs from both the cerebellum and basal ganglia. Surprisingly, the projections to M1 originate from only 30% of the volume of the dentate and <15% of GPi. Thus, the majority of the outputs from the cerebellum and basal ganglia are directed to cortical areas other than M1. PMID- 9952422 TI - Gonadal steroids promote glial differentiation and alter neuronal morphology in the developing hypothalamus in a regionally specific manner. AB - One of the more striking sexual dimorphisms in the adult brain is the synaptic patterning in some hypothalamic nuclei. In the arcuate nucleus (ARC) males have twice the number of axosomatic and one-half the number of axodendritic spine synapses as females. The opposite pattern is observed in the immediately adjacent ventromedial nucleus (VMN). In both cases, early exposure to testosterone dictates adult dimorphism, but the exact timing, mechanism, and site of steroid action remain unknown. Astrocytes also exhibit sexual dimorphisms, and their role in mediating neuronal morphology is becoming increasingly evident. Using Golgi Cox impregnation to examine neuronal morphology and glial fibrillary acidic protein immunoreactivity (GFAP-IR) to characterize astrocytic morphology, we compared structural differences in dendrites and astrocytes from the ARC and VMN in postnatal day 2 rat pups from four hormonally different groups. Consistent with previous observations, testosterone exposure induced a rapid and dramatic stellation response in ARC astrocytes. Coincident with this change in astrocytic morphology was a 37% reduction in the density of dendritic spines on ARC neurons. In contrast, astrocytes in the VMN were poorly differentiated and did not respond to testosterone exposure, nor were there any changes in neuronal dendrite spine density. However, VMN neurons exposed to testosterone had almost double the number of branches compared with that in controls. These data suggest that the degree of maturation and the differentiation of hypothalamic astrocytes in vivo are correlated with the ability of neurons to sprout branches or spines in response to steroid hormones and may underlie regionally specific differences in synaptic patterning. PMID- 9952423 TI - Active motor neurons potentiate their own sensory inputs via glutamate-induced long-term potentiation. AB - Adaptive motor control is based mainly on the processing and integration of proprioceptive feedback information. In crayfish walking leg, many of these operations are performed directly by the motor neurons (MNs), which are connected monosynaptically by sensory afferents (CBTs) originating from a chordotonal organ that encodes vertical limb movements. An in vitro preparation of the crayfish CNS was used to investigate a new control mechanism exerted directly by motor neurons on the sensory inputs themselves. Paired intracellular recordings demonstrated that, in the absence of any presynaptic sensory firing, the spiking activity of a leg MN is able long-lastingly to enhance the efficacy of the CBT-MN synapses. Moreover, this effect is specific to the activated MN because no changes were induced at the afferent synapses of a neighboring silent MN. We report evidence that long-term potentiation (LTP) of the monosynaptic EPSP involves a retrograde system of glutamate transmission from the postsynaptic MN, which induces the activation of a metabotropic glutamate receptor located presynaptically on the CBTs. We demonstrate that LTP at crayfish sensory-motor synapses results exclusively from the long-lasting enhancement of release of acetylcholine from presynaptic sensory afferent terminals, without inducing any modifications in postsynaptic MN properties. Our data indicate that this positive feedback control represents a functional mechanism that may play a key role in the auto organization of sensory-motor networks. PMID- 9952424 TI - Dopamine quinone formation and protein modification associated with the striatal neurotoxicity of methamphetamine: evidence against a role for extracellular dopamine. AB - Methamphetamine-induced toxicity has been shown to require striatal dopamine and to involve mechanisms associated with oxidative stress. Dopamine is a reactive molecule that can oxidize to form free radicals and reactive quinones. Although this has been suggested to contribute to the mechanism of toxicity, the oxidation of dopamine has never been directly measured after methamphetamine exposure. In this study we sought to determine whether methamphetamine-induced toxicity is associated with the oxidation of dopamine by measuring the binding of dopamine quinones to cysteinyl residues on protein. We observed that administration of neurotoxic doses of methamphetamine to rats resulted in a two- to threefold increase in protein cysteinyl-dopamine in the striatum 2, 4, and 8 hr after treatment. When methamphetamine was administered at an ambient temperature of 5 degreesC, no increase in dopamine oxidation products was observed, and toxicity was prevented. Furthermore, as shown by striatal microdialysis, animals treated with methamphetamine at 5 degreesC showed DA release identical to that of animals treated at room temperature. These data suggest that the toxicity of methamphetamine and the associated increase in dopamine oxidation are not exclusively the result of increases in extracellular dopamine. Because dopamine induced modifications of protein structure and function may result in cellular toxicity, it is likely that dopamine oxidation contributes to methamphetamine induced toxicity to dopamine terminals, adding support to the role of dopamine and the evidence of oxidative stress in this lesion model. PMID- 9952425 TI - Effects of ibotenate hippocampal and extrahippocampal destruction on delayed match and -nonmatch-to-sample behavior in rats. AB - The effects of ibotenate lesions of the hippocampus (HIPP) or hippocampus plus collateral damage to extrahippocampal structures (HCX) were investigated in rats trained to criterion on spatial versions of either a delayed-match (DMS) or delayed-nonmatch-to-sample (DNMS) task. After recovery from surgery, animals were retrained at "0" sec delays, then assessed at 0-30 sec delays for 15 d, retrained again at 0 sec delays, and retested for another 25 d on 0-30 sec delays. Pretrained HIPP-lesioned animals showed marked delay-dependent deficits in both tasks that never recovered. Detailed examination of within- and between-trial performance factors, including changes in response preferences, length of previous trial delay, and sequential dependencies, revealed important factors operating in lesioned animals that were either absent or insignificant before the lesion. Pretrained HCX-lesioned animals showed deficits similar to those of HIPP animals, with the noticeable exception of a strong "recency" influence of the previous trial. Another group of HIPP- and HCX-lesioned animals trained on the tasks after the lesion showed reduced impairments of the type described above, suggesting that extrahippocampal structures trained after the lesion can assume the role of the hippocampus to some degree. The findings indicate that both the type of lesion and the previous history of the animal determine the postlesion DMS and DNMS performance of animals suffering damage to the hippocampus and/or related structures. PMID- 9952426 TI - Neural coding of sound frequency by cricket auditory receptors. AB - Crickets provide a useful model to study neural processing of sound frequency. Sound frequency is one parameter that crickets use to discriminate between conspecific signals and sounds made by predators, yet little is known about how frequency is represented at the level of auditory receptors. In this paper, we study the physiological properties of auditory receptor fibers (ARFs) by making single-unit recordings in the cricket Teleogryllus oceanicus. Characteristic frequencies (CFs) of ARFs are distributed discontinuously throughout the range of frequencies that we investigated (2-40 kHz) and appear to be clustered around three frequency ranges (/=18 kHz). A striking characteristic of cricket ARFs is the occurrence of additional sensitivity peaks at frequencies other than CFs. These additional sensitivity peaks allow crickets to detect sound over a wide frequency range, although the CFs of ARFs cover only the frequency bands mentioned above. To the best of our knowledge, this is the first example of the extension of an animal's hearing range through multiple sensitivity peaks of auditory receptors. PMID- 9952427 TI - Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain. AB - Adenovirus-mediated gene transfer into the brain is associated with significant inflammation and activation of anti-vector and anti-transgene immune responses that curtail the gene delivery of adenoviruses and therapeutic efficacy. Elucidating the molecular mediators of inflammatory and immune responses to adenoviruses injected into the brain should allow us to inhibit their inflammatory actions, thereby reducing vector clearance and enhance adenoviral mediated gene transfer into the CNS. Cytokines are primary mediators of the immune response and are released during inflammation. Here we report for the first time that injection of replication-deficient adenovirus vectors into the cerebral ventricles of rats causes a rapid increase in body temperature. This fever response precedes any vector-encoded transgene expression and occurs with vectors encoding no transgene, as well as with vectors encoding a therapeutic transgene i.e., HSV1-thymidine kinase. No fever is detected after infection of the striatum, an important brain target in studies on neurodegeneration. After infection of the brain ventricles, CSF levels of immunoreactive tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta increase significantly (up to 300 fold). In the hypothalamus, the locus of thermoregulation in the brain, only IL 1beta and IL-6 are significantly elevated. A neutralizing TNF-alpha antibody has no effect on adenovirus-induced fever. However, pretreatment with either the IL-1 receptor antagonist or the cyclooxygenase inhibitor flurbiprofen completely abolishes adenovirus-induced fever, suggesting that IL-1 and prostaglandins are direct mediators of this response. These results are the first to demonstrate that IL-1, but not TNF-alpha, is the main mediator of a very early inflammatory response to adenovirus in the brain. PMID- 9952428 TI - Optokinetic and vestibular stimulation determines the spatial orientation of negative optokinetic afternystagmus in the rabbit. AB - Prolonged binocular optokinetic stimulation (OKS) in the rabbit induces a high velocity negative optokinetic afternystagmus (OKAN II) that persists for several hours. We have taken advantage of this uniform nystagmus to study how changes in static head orientation in the pitch plane might influence the orientation of the nystagmus. After horizontal OKS, the rotation axis of the OKAN II remained almost constant in space as it was kept aligned with the gravity vector when the head was pitched by as much as 80 degrees up and 35 degrees down. Moreover, during reorientation, slow-phase eye velocity decreased according to the head pitch angle. Thereafter, we analyzed the space orientation of OKAN II after optokinetic stimulation during which the head and/or the OKS were pitched upward and downward. The rotation axis of OKAN II did not remain aligned with an earth vertical axis nor a head vertical axis, but it tended to be aligned with that of the OKS respace. The slow-phase eye velocity of OKAN II was also affected by the head pitch angle during OKS, because maximal OKAN II velocity occurred at the same head pitch angle as that during optokinetic stimulation. We suggest that OKAN II is coded in gravity-centered rather than in head-centered coordinates, but that this coordinate system may be influenced by optokinetic and vestibular stimulation. Moreover, the velocity attenuation of OKAN II seems to depend on the mismatch between the space-centered nystagmus rotation axis orientation and that of the "remembered" head-centered optokinetic pathway activated by OKS. PMID- 9952429 TI - Responses to the sensory properties of fat of neurons in the primate orbitofrontal cortex. AB - The primate orbitofrontal cortex is a site of convergence of information from primary taste, olfactory, and somatosensory cortical areas. We describe the responses of a population of single neurons in the orbitofrontal cortex that responds to fat in the mouth. The neurons respond, when fatty foods are being eaten, to pure fat such as glyceryl trioleate and also to substances with a similar texture but different chemical composition such as paraffin oil (hydrocarbon) and silicone oil [Si(CH3)2O)n]. This is evidence that the neurons respond to the oral texture of fat, sensed by the somatosensory system. Some of the population of neurons respond unimodally to the texture of fat. Other single neurons show convergence of taste inputs, and others of olfactory inputs, onto single neurons that respond to fat. For example, neurons were found that responded to the mouth feel of fat and the taste of monosodium glutamate (both found in milk), or to the mouth feel of fat and to odor. Feeding to satiety reduces the responses of these neurons to the fatty food eaten, but the neurons still respond to some other foods that have not been fed to satiety. Thus sensory specific satiety for fat is represented in the responses of single neurons in the primate orbitofrontal cortex. Fat is an important constituent of food that affects its palatability and nutritional effects. The findings described provide evidence that the reward value (or pleasantness) of the mouth feel of fat is represented in the primate orbitofrontal cortex and that the representation is relevant to appetite. PMID- 9952430 TI - Genetic analysis of gibberellin biosynthesis. PMID- 9952431 TI - Are homeobox knotted-like genes and cytokinins the leaf architects? PMID- 9952432 TI - Tracheary element differentiation uses a novel mechanism coordinating programmed cell death and secondary cell wall synthesis AB - Tracheary element differentiation requires strict coordination of secondary cell wall synthesis and programmed cell death (PCD) to produce a functional cell corpse. The execution of cell death involves an influx of Ca2+ into the cell and is manifested by rapid collapse of the large hydrolytic vacuole and cessation of cytoplasmic streaming. This precise means of effecting cell death is a prerequisite for postmortem developmental events, including autolysis and chromatin degradation. A 40-kD serine protease is secreted during secondary cell wall synthesis, which may be the coordinating factor between secondary cell wall synthesis and PCD. Specific proteolysis of the extracellular matrix is necessary and sufficient to trigger Ca2+ influx, vacuole collapse, cell death, and chromatin degradation, suggesting that extracellular proteolysis plays a key regulatory role during PCD. We propose a model in which secondary cell wall synthesis and cell death are coordinated by the concomitant secretion of the 40 kD protease and secondary cell wall precursors. Subsequent cell death is triggered by a critical activity of protease or the arrival of substrate signal precursor corresponding with the completion of a functional secondary cell wall. PMID- 9952434 TI - The site of oxygen limitation in soybean nodules AB - In legume nodules the [O2] in the infected cells limits respiration and nitrogenase activity, becoming more severe if nodules are exposed to subambient O2 levels. To identify the site of O2 limitation, adenylate pools were measured in soybean (Glycine max) nodules that were frozen in liquid N2 before being ground, lyophilized, sonicated, and separated on density gradients of nonaqueous solvents (heptane/tetrachloroethylene) to yield fractions enriched in bacteroid or plant components. In nodules maintained in air, the adenylate energy charge (AEC = [ATP + 0.5 ADP]/[ATP + ADP + AMP]) was lower in the plant compartment (0.65 +/- 0.04) than in the bacteroids (0.76 +/- 0.095), but did not change when the nodulated root system was exposed to 10% O2. In contrast, 10% O2 decreased the bacteroid AEC to 0.56 +/- 0.06, leading to the conclusion that they are the primary site of O2 limitation in nodules. To account for the low but unchanged AEC in the plant compartment and for the evidence that mitochondria are localized in O2-enriched microenvironments adjacent to intercellular spaces, we propose that steep adenylate gradients may exist between the site of ATP synthesis (and ADP use) in the mitochondria and the extra-mitochondrial sites of ATP use (and ADP production) throughout the large, infected cells. PMID- 9952433 TI - Structure, properties, and tissue localization of apoplastic alpha-glucosidase in crucifers. AB - Apoplastic alpha-glucosidases occur widely in plants but their function is unknown because appropriate substrates in the apoplast have not been identified. Arabidopsis contains at least three alpha-glucosidase genes; Aglu-1 and Aglu-3 are sequenced and Aglu-2 is known from six expressed sequence tags. Antibodies raised to a portion of Aglu-1 expressed in Escherichia coli recognize two proteins of 96 and 81 kD, respectively, in vegetative tissues of Arabidopsis, broccoli (Brassica oleracea L.), and mustard (Brassica napus L.). The acidic alpha-glucosidase activity from broccoli flower buds was purified using concanavalin A and ion-exchange chromatography. Two active fractions were resolved and both contained a 96-kD immunoreactive polypeptide. The N-terminal sequence from the 96-kD broccoli alpha-glucosidase indicated that it corresponds to the Arabidopsis Aglu-2 gene and that approximately 15 kD of the predicted N terminus was cleaved. The 81-kD protein was more abundant than the 96-kD protein, but it was not active with 4-methylumbelliferyl-alpha-D-glucopyranoside as the substrate and it did not bind to concanavalin A. In situ activity staining using 5-bromo-4-chloro-3-indolyl-alpha-D-glucopyranoside revealed that the acidic alpha glucosidase activity is predominantly located in the outer cortex of broccoli stems and in vascular tissue, especially in leaf traces. PMID- 9952436 TI - Cell-specific production and antimicrobial activity of naphthoquinones in roots of lithospermum erythrorhizon AB - Pigmented naphthoquinone derivatives of shikonin are produced at specific times and in specific cells of Lithospermum erythrorhizon roots. Normal pigment development is limited to root hairs and root border cells in hairy roots grown on "noninducing" medium, whereas induction of additional pigment production by abiotic (CuSO4) or biotic (fungal elicitor) factors increases the amount of total pigment, changes the ratios of derivatives produced, and initiates production of pigment de novo in epidermal cells. When the biological activity of these compounds was tested against soil-borne bacteria and fungi, a wide range of sensitivity was recorded. Acetyl-shikonin and beta-hydroxyisovaleryl-shikonin, the two most abundant derivatives in both Agrobacterium rhizogenes-transformed "hairy-root" cultures and greenhouse-grown plant roots, were the most biologically active of the seven compounds tested. Hyphae of the pathogenic fungi Rhizoctonia solani, Pythium aphanidermatum, and Nectria hematococca induced localized pigment production upon contact with the roots. Challenge by R. solani crude elicitor increased shikonin derivative production 30-fold. We have studied the regulation of this suite of related, differentially produced, differentially active compounds to understand their role(s) in plant defense at the cellular level in the rhizosphere. PMID- 9952435 TI - Quantitative intercellular localization of NADH-dependent glutamate synthase protein in different types of root cells in rice plants AB - The quantitative analysis with immunogold-electron microscopy using a single affinity-purified anti-NADH-glutamate synthase (GOGAT) immunoglobulin G (IgG) as the primary antibody showed that the NADH-GOGAT protein was present in various forms of plastids in the cells of the epidermis and exodermis, in the cortex parenchyma, and in the vascular parenchyma of root tips (<10 mm) of rice (Oryza sativa) seedlings supplied with 1 mM NH4+ for 24 h. The values of the mean immunolabeling density of plastids were almost equal among these different cell types in the roots. However, the number of plastids per individual cell type was not identical, and some parts of the cells in the epidermis and exodermis contained large numbers of plastids that were heavily immunolabeled. Although there was an indication of labeling in the mitochondria using the single-affinity purified anti-NADH-GOGAT IgG, this was not confirmed when a twice-affinity purified IgG was used, indicating an exclusively plastidial location of the NADH GOGAT protein in rice roots. These results, together with previous work from our laboratory (K. Ishiyama, T. Hayakawa, and T. Yamaya [1998] Planta 204: 288-294), suggest that the assimilation of exogeneously supplied NH4+ ions is primarily via the cytosolic glutamine synthetase/plastidial NADH-GOGAT cycle in specific regions of the epidermis and exodermis in rice roots. We also discuss the role of the NADH-GOGAT protein in vascular parenchyma cells. PMID- 9952437 TI - Blue light and abscisic acid independently induce heterophyllous switch in marsilea quadrifolia AB - In natural habitats Marsilea quadrifolia L. produces different types of leaves above and below the water level. In aseptic cultures growth conditions can be manipulated so that leaves of the submerged type are produced continuously. Under such conditions the application of either blue light or an optimal concentration of abscisic acid (ABA) induced the development of aerial-type leaves. When fluridone, an inhibitor of ABA biosynthesis, was added to the culture medium it did not prevent blue light induction of aerial leaf development. During blue light treatment the endogenous ABA level in M. quadrifolia leaves remained unchanged. However, after the plants were transferred to an enriched medium, the ABA level gradually increased, corresponding to a transition in development from the submerged type of leaves to aerial leaves. These results indicate that the blue light signal is not mediated by ABA. Therefore, in the regulation of heterophyllous determination, discrete pathways exist in response to environmental signals. PMID- 9952438 TI - Change in apoplastic aluminum during the initial growth response to aluminum by roots of a tolerant maize variety AB - Root elongation, hematoxylin staining, and changes in the ultrastructure of root tip cells of an Al-tolerant maize variety (Zea mays L. C 525 M) exposed to nutrient solutions with 20 &mgr;M Al (2.1 &mgr;M Al3+ activity) for 0, 4, and 24 h were investigated in relation to the subcellular distribution of Al using scanning transmission electron microscopy and energy-dispersive x-ray microanalysis on samples fixed by different methods. Inhibition of root elongation rates, hematoxylin staining, cell wall thickening, and disturbance of the distribution of pyroantimoniate-stainable cations, mainly Ca, was observed only after 4 and not after 24 h of exposure to Al. The occurrence of these transient, toxic Al effects on root elongation and in cell walls was accompanied by the presence of solid Al-P deposits in the walls. Whereas no Al was detectable in cell walls after 24 h, an increase of vacuolar Al was observed after 4 h of exposure. After 24 h, a higher amount of electron-dense deposits containing Al and P or Si was observed in the vacuoles. These results indicate that in this tropical maize variety, tolerance mechanisms that cause a change in apoplastic Al must be active. Our data support the hypothesis that in Al-tolerant plants, Al can rapidly cross the plasma membrane; these data clearly contradict the former conclusions that Al mainly accumulates in the apoplast and enters the symplast only after severe cell damage has occurred. PMID- 9952439 TI - Glycolytic flux is adjusted to nitrogenase activity in nodules of detopped and argon-treated alfalfa plants AB - To investigate the short-term (30-240 min) interactions among nitrogenase activity, NH4+ assimilation, and plant glycolysis, we measured the concentrations of selected C and N metabolites in alfalfa (Medicago sativa L.) root nodules after detopping and during continuous exposure of the nodulated roots to Ar:O2 (80:20, v/v). Both treatments caused an increase in the ratios of glucose-6 phosphate to fructose-1,6-bisphosphate, fructose-6-phosphate to fructose-1,6 bisphosphate, phosphoenolpyruvate (PEP) to pyruvate, and PEP to malate. This suggested that glycolytic flux was inhibited at the steps catalyzed by phosphofructokinase, pyruvate kinase, and PEP carboxylase. In the Ar:O2-treated plants the apparent inhibition of glycolytic flux was reversible, whereas in the detopped plants it was not. In both groups of plants the apparent inhibition of glycolytic flux was delayed relative to the decline in nitrogenase activity. The decline in nitrogenase activity was followed by a dramatic increase in the nodular glutamate to glutamine ratio. In the detopped plants this was coincident with the apparent inhibition of glycolytic flux, whereas in the Ar:O2-treated plants it preceded the apparent inhibition of glycolytic flux. We propose that the increase in the nodular glutamate to glutamine ratio, which occurs as a result of the decline in nitrogenase activity, may act as a signal to decrease plant glycolytic flux in legume root nodules. PMID- 9952440 TI - In vitro biosynthesis of phosphorylated starch in intact potato amyloplasts AB - Intact amyloplasts from potato (Solanum tuberosum L.) were used to study starch biosynthesis and phosphorylation. Assessed by the degree of intactness and by the level of cytosolic and vacuolar contamination, the best preparations were selected by searching for amyloplasts containing small starch grains. The isolated, small amyloplasts were 80% intact and were free from cytosolic and vacuolar contamination. Biosynthetic studies of the amyloplasts showed that [1 14C]glucose-6-phosphate (Glc-6-P) was an efficient precursor for starch synthesis in a manner highly dependent on amyloplast integrity. Starch biosynthesis from [1 14C]Glc-1-P in small, intact amyloplasts was 5-fold lower and largely independent of amyloplast intactness. When [33P]Glc-6-P was administered to the amyloplasts, radiophosphorylated starch was produced. Isoamylase treatment of the starch followed by high-performance anion-exchange chromatography with pulsed amperometric detection revealed the separated phosphorylated alpha-glucans. Acid hydrolysis of the phosphorylated alpha-glucans and high-performance anion exchange chromatography analyses showed that the incorporated phosphate was preferentially positioned at C-6 of the Glc moiety. The incorporation of radiolabel from Glc-1-P into starch in preparations of amyloplasts containing large grains was independent of intactness and most likely catalyzed by starch phosphorylase bound to naked starch grains. PMID- 9952441 TI - The Arabidopsis CBF gene family is composed of three genes encoding AP2 domain containing proteins whose expression Is regulated by low temperature but not by abscisic acid or dehydration. AB - We have identified two genes from Arabidopsis that show high similarity with CBF1, a gene encoding an AP2 domain-containing transcriptional activator that binds to the low-temperature-responsive element CCGAC and induces the expression of some cold-regulated genes, increasing plant freezing tolerance. These two genes, which we have named CBF2 and CBF3, also encode proteins containing AP2 DNA binding motifs. Furthermore, like CBF1, CBF2 and CBF3 proteins also include putative nuclear-localization signals and potential acidic activation domains. The CBF2 and CBF3 genes are linked to CBF1, constituting a cluster on the bottom arm of chromosome IV. The high level of similarity among the three CBF genes, their tandem organization, and the fact that they have the same transcriptional orientation all suggest a common origin. CBF1, CBF2, and CBF3 show identical expression patterns, being induced very rapidly by low-temperature treatment. However, in contrast to most of the cold-induced plant genes characterized, they are not responsive to abscisic acid or dehydration. Taken together, all of these data suggest that CBF2 and CBF3 may function as transcriptional activators, controlling the level of low-temperature gene expression and promoting freezing tolerance through an abscisic acid-independent pathway. PMID- 9952442 TI - Cloning of nicotianamine synthase genes, novel genes involved in the biosynthesis of phytosiderophores. AB - Nicotianamine synthase (NAS), the key enzyme in the biosynthetic pathway for the mugineic acid family of phytosiderophores, catalyzes the trimerization of S adenosylmethionine to form one molecule of nicotianamine. We purified NAS protein and isolated the genes nas1, nas2, nas3, nas4, nas5-1, nas5-2, and nas6, which encode NAS and NAS-like proteins from Fe-deficient barley (Hordeum vulgare L. cv Ehimehadaka no. 1) roots. Escherichia coli expressing nas1 showed NAS activity, confirming that this gene encodes a functional NAS. Expression of nas genes as determined by northern-blot analysis was induced by Fe deficiency and was root specific. The NAS genes form a multigene family in the barley and rice genomes. PMID- 9952443 TI - Complementary DNA cloning and characterization of ferredoxin localized in bundle sheath cells of maize leaves. AB - In maize (Zea mays L.) two leaf-specific ferredoxin (Fd) isoproteins, Fd I and Fd II, are distributed differentially in mesophyll and bundle-sheath cells. A novel cDNA encoding the precursor of Fd II (pFD2) was isolated by heterologous hybridization using a cDNA for Fd I (pFD1) as a probe. The assignment of the cDNAs to the Fds was verified by capillary liquid-chromatography/electrospray ionization-mass spectrometry. RNA-blot analysis demonstrated that transcripts for Fd I and Fd II accumulated specifically in mesophyll and bundle-sheath cells, respectively. The mature regions of pFD1 and pFD2 were expressed in Escherichia coli as functional Fds. Fd I and Fd II had similar redox potentials of -423 and 406 mV, respectively, but the Km value of Fd-NADP+ reductase for Fd II was about 3-fold larger than that for Fd I. Asparagine at position 65 of Fd II is a unique residue compared with Fd I and other Fds from various plants, which have aspartic acid or glutamic acid at the corresponding position as an electrostatic interaction site with Fd-NADP+ reductase. Substitution of asparagine-65 with aspartic acid increased the affinity of Fd II with Fd-NADP+ reductase to a level comparable to that of Fd I. These structural and functional differences of Fd I and Fd II may be related to their cell-specific expression in the leaves of a C4 plant. PMID- 9952444 TI - Purification of the trehalase GMTRE1 from soybean nodules and cloning of its cDNA. GMTRE1 is expressed at a low level in multiple tissues. AB - Trehalose (alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside), a disaccharide widespread among microbes and lower invertebrates, is generally believed to be nonexistent in higher plants. However, the recent discovery of Arabidopsis genes whose products are involved in trehalose synthesis has renewed interest in the possibility of a function of trehalose in higher plants. We previously showed that trehalase, the enzyme that degrades trehalose, is present in nodules of soybean (Glycine max [L.] Merr.), and we characterized the enzyme as an apoplastic glycoprotein. Here we describe the purification of this trehalase to homogeneity and the cloning of a full-length cDNA encoding this enzyme, named GMTRE1 (G. max trehalase 1). The amino acid sequence derived from the open reading frame of GMTRE1 shows strong homology to known trehalases from bacteria, fungi, and animals. GMTRE1 is a single-copy gene and is expressed at a low but constant level in many tissues. PMID- 9952446 TI - Arabidopsis ent-kaurene oxidase catalyzes three steps of gibberellin biosynthesis. AB - The Arabidopsis GA3 cDNA was expressed in yeast (Saccharomyces cerevisiae) and the ability of the transformed yeast cells to metabolize ent-kaurene was tested. We show by full-scan gas chromatography-mass spectrometry that the transformed cells produce ent-kaurenoic acid, and demonstrate that the single enzyme GA3 (ent kaurene oxidase) catalyzes the three steps of gibberellin biosynthesis from ent kaurene to ent-kaurenoic acid. PMID- 9952447 TI - Evidence for a slow-turnover form of the Ca2+-independent phosphoenolpyruvate carboxylase kinase in the aleurone-endosperm tissue of germinating barley seeds AB - Phosphoenolpyruvate carboxylase (PEPC) activity was detected in aleurone endosperm extracts of barley (Hordeum vulgare) seeds during germination, and specific anti-sorghum (Sorghum bicolor) C4 PEPC polyclonal antibodies immunodecorated constitutive 103-kD and inducible 108-kD PEPC polypeptides in western analysis. The 103- and 108-kD polypeptides were radiolabeled in situ after imbibition for up to 1.5 d in 32P-labeled inorganic phosphate. In vitro phosphorylation by a Ca2+-independent PEPC protein kinase (PK) in crude extracts enhanced the enzyme's velocity and decreased its sensitivity to L-malate at suboptimal pH and [PEP]. Isolated aleurone cell protoplasts contained both phosphorylated PEPC and a Ca2+-independent PEPC-PK that was partially purified by affinity chromatography on blue dextran-agarose. This PK activity was present in dry seeds, and PEPC phosphorylation in situ during imbibition was not affected by the cytosolic protein-synthesis inhibitor cycloheximide, by weak acids, or by various pharmacological reagents that had proven to be effective blockers of the light signal transduction chain and PEPC phosphorylation in C4 mesophyll protoplasts. These collective data support the hypothesis that this Ca2+ independent PEPC-PK was formed during maturation of barley seeds and that its presumed underlying signaling elements were no longer operative during germination. PMID- 9952445 TI - Organellar and cytosolic localization of four phosphoribosyl diphosphate synthase isozymes in spinach. AB - Four cDNAs encoding phosphoribosyl diphosphate (PRPP) synthase were isolated from a spinach (Spinacia oleracea) cDNA library by complementation of an Escherichia coli Deltaprs mutation. The four gene products produced PRPP in vitro from ATP and ribose-5-phosphate. Two of the enzymes (isozymes 1 and 2) required inorganic phosphate for activity, whereas the others were phosphate independent. PRPP synthase isozymes 2 and 3 contained 76 and 87 amino acid extensions, respectively, at their N-terminal ends in comparison with other PRPP synthases. Isozyme 2 was synthesized in vitro and shown to be imported and processed by pea (Pisum sativum) chloroplasts. Amino acid sequence analysis indicated that isozyme 3 may be transported to mitochondria and that isozyme 4 may be located in the cytosol. The deduced amino acid sequences of isozymes 1 and 2 and isozymes 3 and 4 were 88% and 75% identical, respectively. In contrast, the amino acid identities of PRPP synthase isozyme 1 or 2 with 3 or 4 was modest (22%-25%), but the sequence motifs for binding of PRPP and divalent cation-nucleotide were identified in all four sequences. The results indicate that PRPP synthase isozymes 3 and 4 belong to a new class of PRPP synthases that may be specific to plants. PMID- 9952449 TI - The xanthophyll cycle modulates the kinetics of nonphotochemical energy dissipation in isolated light-harvesting complexes, intact chloroplasts, and leaves of spinach AB - We analyzed the kinetics of nonphotochemical quenching of chlorophyll fluorescence (qN) in spinach (Spinacia oleracea) leaves, chloroplasts, and purified light-harvesting complexes. The characteristic biphasic pattern of fluorescence quenching in dark-adapted leaves, which was removed by preillumination, was evidence of light activation of qN, a process correlated with the de-epoxidation state of the xanthophyll cycle carotenoids. Chloroplasts isolated from dark-adapted and light-activated leaves confirmed the nature of light activation: faster and greater quenching at a subsaturating transthylakoid pH gradient. The light-harvesting chlorophyll a/b-binding complexes of photosystem II were isolated from dark-adapted and light-activated leaves. When isolated from light-activated leaves, these complexes showed an increase in the rate of quenching in vitro compared with samples prepared from dark-adapted leaves. In all cases, the quenching kinetics were fitted to a single component hyperbolic function. For leaves, chloroplasts, and light-harvesting complexes, the presence of zeaxanthin was associated with an increased rate constant for the induction of quenching. We discuss the significance of these observations in terms of the mechanism and control of qN. PMID- 9952448 TI - Two Arabidopsis mutants that overproduce ethylene are affected in the posttranscriptional regulation of 1-aminocyclopropane-1-carboxylic acid synthase. AB - The Arabidopsis mutants eto1 (ethylene overproducer) and eto3 produce elevated levels of ethylene as etiolated seedlings. Ethylene production in these seedlings peaks at 60 to 96 h, and then declines back to almost wild-type levels. Ethylene overproduction in eto1 and eto3 is limited mainly to etiolated seedlings; light grown seedlings and various adult tissues produce close to wild-type amounts of ethylene. Several compounds that induce ethylene biosynthesis in wild-type, etiolated seedlings through distinct 1-aminocyclopropane-1-carboxylic acid (ACC) synthase (ACS) isoforms were found to act synergistically with eto1 and eto3, as did the ethylene-insensitive mutation etr1 (ethylene resistant), which blocks feedback inhibition of biosynthesis. ACS activity, the rate-limiting step of ethylene biosynthesis, was highly elevated in both eto1 and eto3 mutant seedlings, even though RNA gel-blot analysis demonstrated that the steady-state level of ACS mRNA was not increased, including that of a novel Arabidopsis ACS gene that was identified. Measurements of the conversion of ACC to ethylene by intact seedlings indicated that the mutations did not affect conjugation of ACC or the activity of ACC oxidase, the final step of ethylene biosynthesis. Taken together, these data suggest that the eto1 and eto3 mutations elevate ethylene biosynthesis by affecting the posttranscriptional regulation of ACS. PMID- 9952450 TI - Apyrase functions in plant phosphate nutrition and mobilizes phosphate from extracellular ATP. AB - ATP, which is present in the extracellular matrix of multicellular organisms and in the extracellular fluid of unicellular organisms, has been shown to function as a signaling molecule in animals. The concentration of extracellular ATP (xATP) is known to be functionally modulated in part by ectoapyrases, membrane associated proteins that cleave the gamma- and beta-phosphates on xATP. We present data showing a previously unreported (to our knowledge) linkage between apyrase and phosphate transport. An apyrase from pea (Pisum sativum) complements a yeast (Saccharomyces cerevisiae) phosphate-transport mutant and significantly increases the amount of phosphate taken up by transgenic plants overexpressing the gene. The transgenic plants show enhanced growth and augmented phosphate transport when the additional phosphate is supplied as inorganic phosphate or as ATP. When scavenging phosphate from xATP, apyrase mobilizes the gamma-phosphate without promoting the transport of the purine or the ribose. PMID- 9952451 TI - Interactions between senescence and leaf orientation determine in situ patterns of photosynthesis and photoinhibition in field-grown rice AB - Photosynthesis and photoinhibition in field-grown rice (Oryza sativa L.) were examined in relation to leaf age and orientation. Two varieties (IR72 and IR65598 112-2 [BSI206]) were grown in the field in the Philippines during the dry season under highly irrigated, well-fertilized conditions. Flag leaves were examined 60 and 100 d after transplanting. Because of the upright nature of 60-d-old rice leaves, patterns of photosynthesis were determined by solar movements: light falling on the exposed surface in the morning, a low incident angle of irradiance at midday, and light striking the opposite side of the leaf blade in the afternoon. There was an early morning burst of CO2 assimilation and high levels of saturation of photosystem II electron transfer as incident irradiance reached a maximum level. However, by midday the photochemical efficiency increased again almost to maximum. Leaves that were 100 d old possessed a more horizontal orientation and were found to suffer greater levels of photoinhibition than younger leaves, and this was accompanied by increases in the de-epoxidation state of the xanthophyll cycle. Older leaves had significantly lower chlorophyll content but only slightly diminished photosynthesis capacity. PMID- 9952452 TI - Rhizosphere bacteria enhance selenium accumulation and volatilization by indian mustard AB - Indian mustard (Brassica juncea L.) accumulates high tissue Se concentrations and volatilizes Se in relatively nontoxic forms, such as dimethylselenide. This study showed that the presence of bacteria in the rhizosphere of Indian mustard was necessary to achieve the best rates of plant Se accumulation and volatilization of selenate. Experiments with the antibiotic ampicillin showed that bacteria facilitated 35% of plant Se volatilization and 70% of plant tissue accumulation. These results were confirmed by inoculating axenic plants with rhizosphere bacteria. Compared with axenic controls, plants inoculated with rhizosphere bacteria had 5-fold higher Se concentrations in roots (the site of volatilization) and 4-fold higher rates of Se volatilization. Plants with bacteria contained a heat-labile compound in their root exudate; when this compound was added to the rhizosphere of axenic plants, Se accumulation in plant tissues increased. Plants with bacteria had an increased root surface area compared with axenic plants; the increased area was unlikely to have caused their increased tissue Se accumulation because they did not accumulate more Se when supplied with selenite or selenomethionine. Rhizosphere bacteria also possibly increased plant Se volatilization because they enabled plants to overcome a rate limiting step in the Se volatilization pathway, i.e. Se accumulation in plant tissues. PMID- 9952454 TI - Flavonoids promote haustoria formation in the root parasite triphysaria versicolor AB - Parasitic plants in the Scrophulariaceae develop infective root structures called haustoria in response to chemical signals released from host-plant roots. This study used a simple in vitro assay to characterize natural and synthetic molecules that induce haustoria in the facultative parasite Triphysaria versicolor. Several phenolic acids, flavonoids, and the quinone 2,6-dimethoxy-p benzoquinone induced haustoria in T. versicolor root tips within hours after treatment. The concentration at which different molecules were active varied widely, the most active being 2, 6-dimethoxy-p-benzoquinone and the anthocyanidin peonidin. Maize (Zea mays) seeds are rich sources of molecules that induce T. versicolor haustoria in vitro, and chromatographic analyses indicated that the active molecules present in maize-seed rinses include anthocyanins, other flavonoids, and simple phenolics. The presence of different classes of inducing molecules in seed rinses was substantiated by the observation that maize kernels deficient in chalcone synthase, a key enzyme in flavonoid biosynthesis, released haustoria-inducing molecules, although at reduced levels compared with wild-type kernels. We discuss these results in light of existing models for host perception in the related parasitic plant Striga. PMID- 9952453 TI - Red bell pepper chromoplasts exhibit in vitro import competency and membrane targeting of passenger proteins from the thylakoidal sec and DeltapH pathways but not the chloroplast signal recognition particle pathway. AB - Chloroplast to chromoplast development involves new synthesis and plastid localization of nuclear-encoded proteins, as well as changes in the organization of internal plastid membrane compartments. We have demonstrated that isolated red bell pepper (Capsicum annuum) chromoplasts contain the 75-kD component of the chloroplast outer envelope translocon (Toc75) and are capable of importing chloroplast precursors in an ATP-dependent fashion, indicating a functional general import apparatus. The isolated chromoplasts were able to further localize the 33- and 17-kD subunits of the photosystem II O2-evolution complex (OE33 and OE17, respectively), lumen-targeted precursors that utilize the thylakoidal Sec and DeltapH pathways, respectively, to the lumen of an internal membrane compartment. Chromoplasts contained the thylakoid Sec component protein, cpSecA, at levels comparable to chloroplasts. Routing of OE17 to the lumen was abolished by ionophores, suggesting that routing is dependent on a transmembrane DeltapH. The chloroplast signal recognition particle pathway precursor major photosystem II light-harvesting chlorophyll a/b protein failed to associate with chromoplast membranes and instead accumulated in the stroma following import. The Pftf (plastid fusion/translocation factor), a chromoplast protein, integrated into the internal membranes of chromoplasts during in vitro assays, and immunoblot analysis indicated that endogenous plastid fusion/translocation factor was also an integral membrane protein of chromoplasts. These data demonstrate that the internal membranes of chromoplasts are functional with respect to protein translocation on the thylakoid Sec and DeltapH pathways. PMID- 9952455 TI - Expression of a soybean gene encoding the tetrapyrrole-synthesis enzyme glutamyl tRNA reductase in symbiotic root nodules. AB - Heme and chlorophyll accumulate to high levels in legume root nodules and in photosynthetic tissues, respectively, and they are both derived from the universal tetrapyrrole precursor delta-aminolevulinic acid (ALA). The first committed step in ALA and tetrapyrrole synthesis is catalyzed by glutamyl-tRNA reductase (GTR) in plants. A soybean (Glycine max) root-nodule cDNA encoding GTR was isolated by complementation of an Escherichia coli GTR-defective mutant for restoration of ALA prototrophy. Gtr mRNA was very low in uninfected roots but accumulated to high levels in root nodules. The induction of Gtr mRNA in developing nodules was subsequent to that of the gene Enod2 (early nodule) and coincided with leghemoglobin mRNA accumulation. Genomic analysis revealed two Gtr genes, Gtr1 and a 3' portion of Gtr2, which were isolated from the soybean genome. RNase-protection analysis using probes specific to Gtr1 and Gtr2 showed that both genes were expressed, but Gtr1 mRNA accumulated to significantly higher levels. In addition, the qualitative patterns of expression of Gtr1 and Gtr2 were similar to each other and to total Gtr mRNA in leaves and nodules of mature plants and etiolated plantlets. The data indicate that Gtr1 is universal for tetrapyrrole synthesis and that a Gtr gene specific for a tissue or tetrapyrrole is unlikely. We suggest that ALA synthesis in specialized root nodules involves an altered spatial expression of genes that are otherwise induced strongly only in photosynthetic tissues of uninfected plants. PMID- 9952457 TI - Water deficit and spatial pattern of leaf development. Variability In responses can Be simulated using a simple model of leaf development AB - We analyzed the effect of short-term water deficits at different periods of sunflower (Helianthus annuus L.) leaf development on the spatial and temporal patterns of tissue expansion and epidermal cell division. Six water-deficit periods were imposed with similar and constant values of soil water content, predawn leaf water potential and [ABA] in the xylem sap, and with negligible reduction of the rate of photosynthesis. Water deficit did not affect the duration of expansion and division. Regardless of their timing, deficits reduced relative expansion rate by 36% and relative cell division rate by 39% (cells blocked at the G0-G1 phase) in all positions within the leaf. However, reductions in final leaf area and cell number in a given zone of the leaf largely differed with the timing of deficit, with a maximum effect for earliest deficits. Individual cell area was only affected during the periods when division slowed down. These behaviors could be simulated in all leaf zones and for all timings by assuming that water deficit affects relative cell division rate and relative expansion rate independently, and that leaf development in each zone follows a stable three-phase pattern in which duration of each phase is stable if expressed in thermal time (C. Granier and F. Tardieu [1998b] Plant Cell Environ 21: 695 703). PMID- 9952456 TI - Mutations affecting induction of glycolytic and fermentative genes during germination and environmental stresses in Arabidopsis. AB - Expression of the alcohol dehydrogenase gene (ADH) of Arabidopsis is known to be induced by environmental stresses and regulated developmentally. We used a negative-selection approach to isolate mutants that were defective in regulating the expression of the ADH gene during seed germination; we then characterized three recessive mutants, aar1-1, aar1-2, and aar2-1, which belong to two complementation groups. In addition to their defects during seed germination, mutations in the AAR1 and AAR2 genes also affected anoxic and hypoxic induction of ADH and other glycolytic genes in mature plants. The aar1 and aar2 mutants were also defective in responding to cold and osmotic stress. The two allelic mutants aar1-1and aar1-2 exhibited different phenotypes under cold and osmotic stresses. Based on our results we propose that these mutants are defective in a late step of the signaling pathways that lead to increased expression of the ADH gene and glycolytic genes. PMID- 9952458 TI - Purification and characterization of a NADPH-dependent aldehyde reductase from mung bean that detoxifies eutypine, a toxin from eutypa lata1 AB - Eutypine (4-hydroxy-3-[3-methyl-3-butene-1-ynyl] benzaldehyde) is a toxin produced by Eutypa lata, the causal agent of eutypa dieback in the grapevine (Vitis vinifera). Eutypine is enzymatically converted by numerous plant tissues into eutypinol (4-hydroxy-3-[3-methyl-3-butene-1-ynyl] benzyl alcohol), a metabolite that is nontoxic to grapevine. We report a four-step procedure for the purification to apparent electrophoretic homogeneity of a eutypine-reducing enzyme (ERE) from etiolated mung bean (Vigna radiata) hypocotyls. The purified protein is a monomer of 36 kD, uses NADPH as a cofactor, and exhibits a Km value of 6.3 &mgr;M for eutypine and a high affinity for 3- and 4-nitro-benzaldehyde. The enzyme failed to catalyze the reverse reaction using eutypinol as a substrate. ERE detoxifies eutypine efficiently over a pH range from 6.2 to 7.5. These data strongly suggest that ERE is an aldehyde reductase that could probably be classified into the aldo-keto reductase superfamily. We discuss the possible role of this enzyme in eutypine detoxification. PMID- 9952459 TI - The two major types of plant plasma membrane H+-ATPases show different enzymatic properties and confer differential pH sensitivity of yeast growth. AB - The proton-pumping ATPase (H+-ATPase) of the plant plasma membrane is encoded by two major gene subfamilies. To characterize individual H+-ATPases, PMA2, an H+ ATPase isoform of tobacco (Nicotiana plumbaginifolia), was expressed in Saccharomyces cerevisiae and found to functionally replace the yeast H+-ATPase if the external pH was kept above 5.0 (A. de Kerchove d'Exaerde, P. Supply, J.P. Dufour, P. Bogaerts, D. Thines, A. Goffeau, M. Boutry [1995] J Biol Chem 270: 23828-23837). In the present study we replaced the yeast H+-ATPase with PMA4, an H+-ATPase isoform from the second subfamily. Yeast expressing PMA4 grew at a pH as low as 4.0. This was correlated with a higher acidification of the external medium and an approximately 50% increase of ATPase activity compared with PMA2. Although both PMA2 and PMA4 had a similar pH optimum (6.6-6.8), the profile was different on the alkaline side. At pH 7.2 PMA2 kept more than 80% of the maximal activity, whereas that of PMA4 decreased to less than 40%. Both enzymes were stimulated up to 3-fold by 100 microgram/mL lysophosphatidylcholine, but this stimulation vanished at a higher concentration in PMA4. These data demonstrate functional differences between two plant H+-ATPases expressed in the same heterologous host. Characterization of two PMA4 mutants selected to allow yeast growth at pH 3.0 revealed that mutations within the carboxy-terminal region of PMA4 could still improve the enzyme, resulting in better growth of yeast cells. PMID- 9952460 TI - Molecular cloning and expression analysis of the mitochondrial pyruvate dehydrogenase from maize. AB - Four cDNAs, one encoding an alpha-subunit and three encoding beta-subunits of the mitochondrial pyruvate dehydrogenase, were isolated from maize (Zea mays L.) libraries. The deduced amino acid sequences of both alpha- and beta-subunits are approximately 80% identical with Arabidopsis and pea (Pisum sativum L.) homologs. The mature N terminus was determined for the beta-subunit by microsequencing the protein purified from etiolated maize shoot mitochondria and was resolved by two dimensional gel electrophoresis. This single isoelectric species comprised multiple isoforms. Both alpha- and beta-subunits are encoded by multigene families in maize, as determined by Southern-blot analyses. RNA transcripts for both alpha- and beta-subunits were more abundant in roots than in young leaves or etiolated shoots. Pyruvate dehydrogenase activity was also higher in roots (5 fold) compared with etiolated shoots and leaves. Both subunits were present at similar levels in all tissues examined, indicating coordinated gene regulation. The protein levels were highest in heterotrophic organs and in pollen, which contained about 2-fold more protein than any other organ examined. The relative abundance of these proteins in nonphotosynthetic tissues may reflect a high cellular content of mitochondria, a high level of respiratory activity, or an extra plastidial requirement for acetate. PMID- 9952461 TI - Curvature induced by amyloplast magnetophoresis in protonemata of the moss Ceratodon purpureus. AB - After gravistimulation of Ceratodon purpureus (Hedw.) Brid. protonemata in the dark, amyloplast sedimentation was followed by upward curvature in the wild-type (WT) and downward curvature in the wwr mutant (wrong way response). We used ponderomotive forces induced by high-gradient magnetic fields (HGMF) to simulate the effect of gravity and displace the presumptive statoliths. The field was applied by placing protonemata either between two permanent magnets at the edge of the gap, close to the edge of a magnetized ferromagnetic wedge, or close to a small (<1 mm) permanent magnet. Continuous application of an HGMF in all three configurations resulted in plastid displacement and induced curvature in tip cells of WT and wwr protonemata. WT cells curved toward the HGMF, and wwr cells curved away from the HGMF, comparable to gravitropism. Plastids isolated from protonemal cultures had densities ranging from 1.24 to 1.38 g cm-3. Plastid density was similar for both genotypes, but the mutant contained larger plastids than the WT. The size difference might explain the stronger response of the wwr protonemata to the HGMF. Our data support the plastid-based theory of gravitropic sensing and suggest that HGMF-induced ponderomotive forces can substitute for gravity. PMID- 9952462 TI - Ectopic expression of the maize homeobox gene liguleless3 alters cell fates in the leaf. AB - The semidominant mutation Liguleless3-O (Lg3-O) causes a blade-to-sheath transformation at the midrib region of the maize (Zea mays L.) leaf. We isolated a full-length lg3 cDNA containing a knotted1-like family homeobox. Six Lg3-O partial revertant alleles caused by insertion of a Mutator (Mu) transposon and two deletion derivatives were isolated and used to verify that our knotted1-like cDNA corresponds to the LG3 message. In wild-type plants the LG3 mRNA is expressed in apical regions but is not expressed in leaves. In mutant plants harboring any of three dominant lg3 alleles (Lg3-O, -Mlg, and -347), LG3 mRNA is expressed in leaf sheath tissue, indicating that the Lg3 phenotype is due to ectopic expression of the gene. The Lg3-O revertant alleles represent two classes of Lg3 phenotypes that correlate well with the level of ectopic Lg3 expression. High levels of ectopic LG3 mRNA expression results in a severe Lg3 phenotype, whereas weak ectopic Lg3 expression results in a mild Lg3 phenotype. We propose that ectopic Lg3 expression early in leaf development causes the blade-to-sheath transformation, but the level of expression determines the extent of the transformation. PMID- 9952463 TI - ADP-Dependent phosphorylation regulates association of a DNA-binding complex with the barley chloroplast psbD blue-light-responsive promoter. AB - The chloroplast gene psbD encodes D2, a chlorophyll-binding protein located in the photosystem II reaction center. Transcription of psbD in higher plants involves at least three promoters, one of which is regulated by blue light. The psbD blue-light-regulated promoter (BLRP) consists of a -10 promoter element and an activating complex, AGF, that binds immediately upstream of -35. A second sequence-specific DNA-binding complex, PGTF, binds upstream of AGF between -71 and -100 in the barley (Hordeum vulgare) psbD BLRP. In this study we report that ADP-dependent phosphorylation selectively inhibits the binding of PGTF to the barley psbD BLRP. ATP at high concentrations (1-5 mM) inhibits PGTF binding, but in the presence of phosphocreatine and phosphocreatine kinase, this capacity is lost, presumably due to scavenging of ADP. ADP inhibits PGTF binding at relatively low concentrations (0.1 mM), whereas other nucleotides are unable to mediate this response. ADP-mediated inhibition of PGTF binding is reduced in the presence of the protein kinase inhibitor K252a. This and other results suggest that ADP-dependent phosphorylation of PGTF (or some associated protein) inhibits binding of PGTF to the psbD BLRP and reduces transcription. ADP-dependent phosphorylation is expected to increase in darkness in parallel with the rise in ADP levels in chloroplasts. ADP-dependent phosphorylation in chloroplasts may, therefore, in coordination, inactivate enzymes involved in carbon assimilation, protein synthesis, and transcription during diurnal light/dark cycles. PMID- 9952465 TI - Regulation of growth anisotropy in well-watered and water-stressed maize roots. II. Role Of cortical microtubules and cellulose microfibrils AB - We tested the hypothesis that the degree of anisotropic expansion of plant tissues is controlled by the degree of alignment of cortical microtubules or cellulose microfibrils. Previously, for the primary root of maize (Zea mays L.), we quantified spatial profiles of expansion rate in length, radius, and circumference and the degree of growth anisotropy separately for the stele and cortex, as roots became thinner with time from germination or in response to low water potential (B.M. Liang, A.M. Dennings, R.E. Sharp, T.I. Baskin [1997] Plant Physiol 115:101-111). Here, for the same material, we quantified microtubule alignment with indirect immunofluorescence microscopy and microfibril alignment throughout the cell wall with polarized-light microscopy and from the innermost cell wall layer with electron microscopy. Throughout much of the growth zone, mean orientations of microtubules and microfibrils were transverse, consistent with their parallel alignment specifying the direction of maximal expansion rate (i.e. elongation). However, where microtubule alignment became helical, microfibrils often made helices of opposite handedness, showing that parallelism between these elements was not required for helical orientations. Finally, contrary to the hypothesis, the degree of growth anisotropy was not correlated with the degree of alignment of either microtubules or microfibrils. The mechanisms plants use to specify radial and tangential expansion rates remain uncharacterized. PMID- 9952464 TI - The interaction between cold and light controls the expression of the cold regulated barley gene cor14b and the accumulation of the corresponding protein. AB - We report the expression of the barley (Hordeum vulgare L.) COR (cold-regulated) gene cor14b (formerly pt59) and the accumulation of its chloroplast-localized protein product. A polyclonal antibody raised against the cor14b-encoded protein detected two chloroplast COR proteins: COR14a and COR14b. N-terminal sequencing of COR14a and expression of cor14b in Arabidopsis plants showed that COR14a is not encoded by the cor14b sequence, but it shared homology with the wheat (Triticum aestivum L.) WCS19 COR protein. The expression of cor14b was strongly impaired in the barley albino mutant an, suggesting the involvement of a plastidial factor in the control of gene expression. Low-level accumulation of COR14b was induced by cold treatment in etiolated plants, although cor14b expression and protein accumulation were enhanced after a short light pulse. Light quality was a determining factor in regulating gene expression: red or blue but not far-red or green light pulses were able to promote COR14b accumulation in etiolated plants, suggesting that phytochrome and blue light photoreceptors may be involved in the control of cor14b gene expression. Maximum accumulation of COR14b was reached only when plants were grown and/or hardened under the standard photoperiod. The effect of light on the COR14b stability was demonstrated by using transgenic Arabidopsis. These plants constitutively expressed cor14b mRNAs regardless of temperature and light conditions; nevertheless, green plants accumulated about twice as much COR14b protein as etiolated plants. PMID- 9952466 TI - The wheat peptidyl prolyl cis-trans-isomerase FKBP77 is heat induced and developmentally regulated. AB - We isolated a cDNA encoding a 568-amino acid, heat-stress-induced peptidyl prolyl isomerase belonging to the FK506-binding-protein (FKBP) family. The open reading frame encodes for a peptidyl prolyl isomerase that possesses three FKBP-12-like domains, a putative tetratricopeptide motif, and a calmodulin-binding domain. Specific antibodies showed that the open reading frame encodes a heat-induced 77 kD protein, the wheat FKBP77 (wFKBP77), which exhibits 84% identity with the wFKBP73 and 42% identity with the human FKBP59. Because of the high similarity in sequence to wFKBP73, wFKBP77 was designated as the heat-induced isoform. The wFKBP77 mRNA steady-state level was 14-fold higher at 37 degreesC than at 25 degreesC. The wFKBP77 transcript abundance was the highest in mature embryos that had imbibed and 2-d-old green shoots exposed to 37 degreesC, and decreased to 6% in 6-d-old green shoots. The transcript level returned to the level detected at 25 degreesC after recovery of the embryos for 90 min at 25 degreesC. We compared wFKBP73 and wFKBP77 with the heat-shock proteins having cognate and heat-stress induced counterparts. PMID- 9952467 TI - Purification and cDNA cloning of isochorismate synthase from elicited cell cultures of Catharanthus roseus. AB - Isochorismate is an important metabolite formed at the end of the shikimate pathway, which is involved in the synthesis of both primary and secondary metabolites. It is synthesized from chorismate in a reaction catalyzed by the enzyme isochorismate synthase (ICS; EC 5.4.99.6). We have purified ICS to homogeneity from elicited Catharanthus roseus cell cultures. Two isoforms with an apparent molecular mass of 64 kD were purified and characterized. The Km values for chorismate were 558 and 319 microM for isoforms I and II, respectively. The isoforms were not inhibited by aromatic amino acids and required Mg2+ for enzyme activity. Polymerase chain reaction on a cDNA library from elicited C. roseus cells with a degenerated primer based on the sequence of an internal peptide from isoform II resulted in an amplification product that was used to screen the cDNA library. This led to the first isolation, to our knowledge, of a plant ICS cDNA. The cDNA encodes a protein of 64 kD with an N-terminal chloroplast-targeting signal. The deduced amino acid sequence shares homology with bacterial ICS and also with anthranilate synthases from plants. Southern analysis indicates the existence of only one ICS gene in C. roseus. PMID- 9952468 TI - Use of ubiquitin fusions to augment protein expression in transgenic plants. AB - A major goal of plant biotechnology is the production of genetically engineered crops that express natural or foreign proteins at high levels. To enhance protein accumulation in transgenic plants, we developed a set of vectors that express proteins and peptides as C-terminal translational fusions with ubiquitin (UBQ). Studies of several proteins in tobacco (Nicotiana tabacum) showed that: (a) proteins can be readily expressed in plants as UBQ fusions; (b) by the action of endogenous UBQ-specific proteases (Ubps), these fusions are rapidly and precisely processed in vivo to release the fused protein moieties in free forms; (c) the synthesis of a protein as a UBQ fusion can significantly augment its accumulation; (d) proper processing and localization of a protein targeted to either the apoplast or the chloroplast is not affected by the N-terminal UBQ sequence; and (e) single amino acid substitutions surrounding the cleavage site can inhibit in vivo processing of the fusion by Ubps. Noncleavable UBQ fusions of beta-glucuronidase became extensively modified, with additional UBQs in planta. Because multiubiquitinated proteins are the preferred substrates of the 26S proteasome, noncleavable fusions may be useful for decreasing protein half-life. Based on their ability to augment protein accumulation and the sequence specificity of Ubps, UBQ fusions offer a versatile way to express plant proteins. PMID- 9952470 TI - Manipulation of in vivo sorbitol production alters boron uptake and transport in tobacco AB - Recent evidence that some species can retranslocate boron as complexes with sugar alcohols in the phloem suggests a possible mechanism for enhancing boron efficiency. We investigated the relationship between sugar alcohol (sorbitol) content, boron uptake and distribution, and translocation of foliar-applied, isotopically enriched 10B in three lines of tobacco (Nicotiana tabacum) plants differing in sorbitol production. In tobacco line S11, transformed with sorbitol 6-phosphate dehydrogenase, the production of sorbitol was accompanied by an increase in the concentration of boron in plant tissues and an increased uptake of boron compared with either tobacco line A4, transformed with antisense orientation of sorbitol-6-phosphate dehydrogenase, or wild-type tobacco (line SR1, zero-sorbitol producer). Foliar application of 10B to mature leaves was translocated to the meristematic tissues only in line S11. These results demonstrate that the concentration of the boron-complexing sugar alcohol in the plant tissue has a significant effect on boron uptake and distribution in plants, whereas the translocation of the foliar-applied 10B from the mature leaves to the meristematic tissues verifies that boron is mobile in sorbitol-producing plants (S11) as we reported previously. This suggests that selection or transgenic generation of cultivars with an increased sugar alcohol content can result in increased boron uptake, with no apparent negative effects on short-term growth. PMID- 9952469 TI - Characterization of N-glycans from Arabidopsis. Application to a fucose-deficient mutant. AB - The structures of glycans N-linked to Arabidopsis proteins have been fully identified. From immuno- and affinodetections on blots, chromatography, nuclear magnetic resonance, and glycosidase sequencing data, we show that Arabidopsis proteins are N-glycosylated by high-mannose-type N-glycans from Man5GlcNAc2 to Man9GlcNAc2, and by xylose- and fucose (Fuc)-containing oligosaccharides. However, complex biantenary structures containing the terminal Lewis a epitope recently reported in the literature (A. -C. Fitchette-Laine, V. Gomord, M. Cabanes, J.-C. Michalski, M. Saint Macary, B. Foucher, B. Cavalier, C. Hawes, P. Lerouge, and L. Faye [1997] Plant J 12: 1411-1417) were not detected. A similar study was done on the Arabidopsis mur1 mutant, which is affected in the biosynthesis of L-Fuc. In this mutant, one-third of the Fuc residues of the xyloglucan has been reported to be replaced by L-galactose (Gal) (E. Zablackis, W.S. York, M. Pauly, S. Hantus, W.D. Reiter, C.C.S. Chapple, P. Albersheim, and A. Darvill [1996] Science 272: 1808-1810). N-linked glycans from the mutant were identified and their structures were compared with those isolated from the wild type plants. In about 95% of all N-linked glycans from the mur1 plant, L-Fuc residues were absent and were not replaced by another monosaccharide. However, in the remaining 5%, L-Fuc was found to be replaced by a hexose residue. From nuclear magnetic resonance and mass spectrometry data of the mur1 N-glycans, and by analogy with data reported on mur1 xyloglucan, this subpopulation of N-linked glycans was proposed to be L-Gal-containing N-glycans resulting from the replacement of L-Fuc by L-Gal. PMID- 9952471 TI - Changes of mitochondrial properties in maize seedlings associated with selection for germination at low temperature. Fatty acid composition, cytochrome c oxidase, and adenine nucleotide translocase activities AB - Mitochondria are affected by low temperature during seedling establishment in maize (Zea mays L.). We evaluated the associated changes in the mitochondrial properties of populations selected for high (C4-H) and low (C4-L) germination levels at 9.5 degreesC. When seedlings of the two populations were grown at 14 degreesC (near the lower growth limit), the mitochondrial inner membranes of C4-H showed a higher percentage of 18-carbon unsaturated fatty acids, a higher fluidity, and a higher activity of cytochrome c oxidase. We found a positive relationship between these properties and the activity of a mitochondrial peroxidase, allowing C4-H to reduce lipid peroxidation relative to C4-L. The specific activity of reconstituted ATP/ADP translocase was positively associated with this peroxidase activity, suggesting that translocase activity is also affected by chilling. The level of oxidative stress and defense mechanisms are differently expressed in tolerant and susceptible populations when seedlings are grown at a temperature near the lower growth limit. Thus, the interaction between membrane lipids and cytochrome c oxidase seems to play a key role in maize chilling tolerance. Furthermore, the divergent-recurrent selection procedure apparently affects the allelic frequencies of genes controlling such an interaction. PMID- 9952472 TI - Differential expression of three members of the 1-aminocyclopropane-1-carboxylate synthase gene family in carnation AB - We investigated the expression patterns of three 1-aminocyclopropane-1 carboxylate (ACC) synthase genes in carnation (Dianthus caryophyllus cv White Sim) under conditions previously shown to induce ethylene biosynthesis. These included treatment of flowers with 2,4-dichlorophenoxyacetic acid, ethylene, LiCl, cycloheximide, and natural and pollination-induced flower senescence. Accumulation of ACC synthase transcripts in leaves following mechanical wounding and treatment with 2,4-dichlorophenoxyacetic acid or LiCl was also determined by RNA gel-blot analysis. As in other species, the carnation ACC synthase genes were found to be differentially regulated in a tissue-specific manner. DCACS2 and DCACS3 were preferentially expressed in styles, whereas DCACS1 mRNA was most abundant in petals. Cycloheximide did not induce increased accumulation of ACC synthase transcripts in carnation flowers, whereas the expression of ACC synthase was up-regulated by auxin, ethylene, LiCl, pollination, and senescence in a floral-organ-specific manner. Expression of the three ACC synthases identified in carnation did not correspond to elevated ethylene biosynthesis from wounded or auxin-treated leaves, and there are likely additional members of the carnation ACC synthase gene family responsible for ACC synthase expression in vegetative tissues. PMID- 9952473 TI - Feedback control and diurnal regulation of gibberellin 20-oxidase transcript levels in potato. AB - Tuber formation in potato (Solanum tuberosum) is promoted by short photoperiods and is inhibited by gibberellins (GAs). Endogenous levels of GA1 were shown to decrease in stolons and leaves of potato plants induced to tuberize, which suggests that photoperiodic regulation of GA biosynthesis may play a role in tuber induction. We report the isolation of three potato cDNA clones (StGA20ox1 3) encoding GA 20-oxidase, a key regulatory enzyme in the GA-biosynthetic pathway. Using northern analysis, we detected a differential pattern of tissue specific expression of the mRNAs corresponding to these clones. StGA20ox mRNAs were also very abundant in leaves of the potato ga1 mutant, which is blocked in the 13-hydroxylation step, and were strongly down-regulated by gibberellic acid, suggesting a feedback regulation of these genes. In plants grown in short-day (inductive) conditions, levels of the StGA20ox transcripts in leaves fluctuated during a 24-h period, with a peak of accumulation observed about 4 h after the lights were turned off. Interruption of the night with a 30-min "night break" of light (noninductive conditions) did not have a marked effect on the levels of accumulation of the three GA 20-oxidase mRNAs during the day, but it induced a second peak of expression of StGA20ox1 and StGA20ox3 transcripts late in the night. This observation, together with the finding that StGA20ox1 mRNA is expressed at high levels in leaves, suggests that night-break induction of this gene might play a role in the control of tuberization by regulating endogenous levels of GAs in response to daylength conditions. PMID- 9952474 TI - Separating growth from elastic deformation during cell enlargement AB - Plants change size by deforming reversibly (elastically) whenever turgor pressure changes, and by growing. The elastic deformation is independent of growth because it occurs in nongrowing cells. Its occurrence with growth has prevented growth from being observed alone. We investigated whether the two processes could be separated in internode cells of Chara corallina Klien ex Willd., em R.D.W. by injecting or removing cell solution with a pressure probe to change turgor while the cell length was continuously measured. Cell size changed immediately when turgor changed, and growth rates appeared to be altered. Low temperature eliminated growth but did not alter the elastic effects. This allowed elastic deformation measured at low temperature to be subtracted from elongation at warm temperature in the same cell. After the subtraction, growth alone could be observed for the first time. Alterations in turgor caused growth to change rapidly to a new, steady rate with no evidence of rapid adjustments in wall properties. This turgor response, together with the marked sensitivity of growth to temperature, suggested that the growth rate was not controlled by inert polymer extension but rather by biochemical reactions that include a turgor sensitive step. PMID- 9952475 TI - Nitrate transport and not photoinhibition limits growth of the freshwater Cyanobacterium synechococcus species PCC 6301 at low temperature. AB - The effect of low temperature on cell growth, photosynthesis, photoinhibition, and nitrate assimilation was examined in the cyanobacterium Synechococcus sp. PCC 6301 to determine the factor that limits growth. Synechococcus sp. PCC 6301 grew exponentially between 20 degreesC and 38 degreesC, the growth rate decreased with decreasing temperature, and growth ceased at 15 degreesC. The rate of photosynthetic oxygen evolution decreased more slowly with temperature than the growth rate, and more than 20% of the activity at 38 degreesC remained at 15 degreesC. Oxygen evolution was rapidly inactivated at high light intensity (3 mE m-2 s-1) at 15 degreesC. Little or no loss of oxygen evolution was observed under the normal light intensity (250 microE m-2 s-1) for growth at 15 degreesC. The decrease in the rate of nitrate consumption by cells as a function of temperature was similar to the decrease in the growth rate. Cells could not actively take up nitrate or nitrite at 15 degreesC, although nitrate reductase and nitrite reductase were still active. These data demonstrate that growth at low temperature is not limited by a decrease in the rate of photosynthetic electron transport or by photoinhibition, but that inactivation of the nitrate/nitrite transporter limits growth at low temperature. PMID- 9952478 TI - Optical model analysis of 200 MeV p PMID- 9952479 TI - p-11B spectroscopic factor from the interference of potential scattering and elastic transfer at low energies. PMID- 9952477 TI - Reply PMID- 9952476 TI - Biochemical analysis of plant protection afforded by a nonpathogenic endophytic mutant of colletotrichum magna AB - A nonpathogenic mutant of Colletotrichum magna (path-1) was previously shown to protect watermelon (Citrullus lanatus) and cucumber (Cucumis sativus) seedlings from anthracnose disease elicited by wild-type C. magna. Disease protection was observed in stems of path-1-colonized cucurbits but not in cotyledons, indicating that path-1 conferred tissue-specific and/or localized protection. Plant biochemical indicators of a localized and systemic (peroxidase, phenylalanine ammonia-lyase, lignin, and salicylic acid) "plant-defense" response were investigated in anthracnose-resistant and -susceptible cultivars of cucurbit seedlings exposed to four treatments: (1) water (control), (2) path-1 conidia, (3) wild-type conidia, and (4) challenge conditions (inoculation into path-1 conidia for 48 h and then exposure to wild-type conidia). Collectively, these analyses indicated that disease protection in path-1-colonized plants was correlated with the ability of these plants to mount a defense response more rapidly and to equal or greater levels than plants exposed to wild-type C. magna alone. Watermelon plants colonized with path-1 were also protected against disease caused by Colletotrichum orbiculare and Fusarium oxysporum. A model based on the kinetics of plant-defense activation is presented to explain the mechanism of path-1-conferred disease protection. PMID- 9952480 TI - Microscopic and semimicroscopic analysis of the reaction 27Al(p, alpha )24Mg in the energy range between 20 and 45 MeV. PMID- 9952481 TI - Hyperspherical formalism for the photoeffect of the alpha particle. PMID- 9952482 TI - Two-body effects in triton photodisintegration sum rules. PMID- 9952485 TI - Microscopic foundations of Dirac phenomenology. PMID- 9952484 TI - Fragmentation instabilities in nuclear systems. PMID- 9952483 TI - Channel cross correlation and intermediate resonance in the 55Mn(p,p)55Mn and 55Mn(p, alpha )52Cr reactions. PMID- 9952487 TI - Scattering of 14.6 MeV neutrons from Fe: Neutron emission cross section measurements. PMID- 9952486 TI - Scattering of 14.6 MeV neutrons from Fe: Investigation of structure in neutron emission spectra. PMID- 9952488 TI - Coulomb excitation of cadmium isotopes with protons. PMID- 9952489 TI - Energy dependence of the absorptive potential for sub-Coulomb energy proton bombardment of zirconium and molybdenum isotopes. PMID- 9952490 TI - Proton stripping to outer subshells and the damping of single-particle states: 116Sn, 144Sm, and 208Pb( alpha,t) reactions at 80 MeV. PMID- 9952491 TI - Test of microscopic optical model potentials for neutron elastic scattering at 14.6 MeV over a wide mass range. PMID- 9952492 TI - Energy dependence of (p,t) analyzing powers arising from strong, sequential, two step processes with j dependence. PMID- 9952493 TI - Deep-inelastic reactions of 16O+48Ti at 100 MeV. PMID- 9952494 TI - Fokker-Planck and linear transport solutions to collective flow in heavy ion collisions. PMID- 9952495 TI - Particle emission in the light heavy-ion fusion reactions: 14N, 16,18O+ 12C. PMID- 9952496 TI - High energy approximations for nuclear knockout form factors at small momentum transfer. PMID- 9952497 TI - Coherent KL0-->KS0 regeneration on Cu. PMID- 9952499 TI - Nuclear magnetic moments of 44.3 s 107Agm and 39.8 s 109Agm. PMID- 9952498 TI - Pion inelastic scattering to giant resonances and low-lying collective states in 118Sn and 40Ca. PMID- 9952500 TI - Measurements of atomic level widths in thulium: Effect on the measurement of neutrino mass from tritium beta decay spectra. PMID- 9952501 TI - Dynamical basis generation method with an application to the four-nucleon problem. PMID- 9952502 TI - Covariant soliton dynamics: Structure of the nucleon. PMID- 9952503 TI - Many-body soliton dynamics: Modification of nucleon properties in nuclei. PMID- 9952504 TI - Laser spectroscopy of the transitional nucleus 151Sm. PMID- 9952505 TI - Medium energy gamma rays following radiative capture of 50 MeV polarized protons on 11B. PMID- 9952506 TI - Two-spectator quasifree scattering process in the 2H(d,pn)pn reaction at 108 MeV. PMID- 9952508 TI - Discrete ambiguity in the nonrelativistic optical potential for 12C at 400 MeV and its resolution by spin-rotation data. PMID- 9952507 TI - Consequences of Pauli effects in 6Li and the reaction 6Li(e,e'd)4He. PMID- 9952509 TI - Angular momentum effects in the pi -nn bound-state problem. PMID- 9952510 TI - Pair clustering and giant pairing resonances. PMID- 9952511 TI - Kinematics of threshold ( gamma, pi 0) reactions. PMID- 9952512 TI - Narrow widths of Lambda single particle states in hypernuclei. PMID- 9952513 TI - Extra entropy production due to nonequilibrium phase transitions in relativistic heavy ion reactions. PMID- 9952514 TI - Isospin dependence in the central real part of the optical model potential. PMID- 9952515 TI - Total neutrino-scattering cross sections and total muon-capture rates in nuclei. PMID- 9952516 TI - Mass dispersion through particle emission from a vibrating nucleus. PMID- 9952518 TI - Dual model form factors and pion photoproduction. PMID- 9952517 TI - Coulomb sum rule: Systematic comparison with experimental data. PMID- 9952519 TI - Dual model form factors and pion photoproduction. PMID- 9952520 TI - Erratum: Deuteron forward photodisintegration PMID- 9952521 TI - Measurements of spin-correlation parameters ALL and ASL for p PMID- 9952522 TI - Inclusive pion production in 330, 400, and 500 MeV proton-nucleus collisions. PMID- 9952523 TI - Precompound limits of linear momentum transfer in heavy ion reactions. PMID- 9952524 TI - Shape evolution in the transitional gadolinium, dysprosium, erbium, and ytterbium nuclei. PMID- 9952525 TI - Meson-exchange approach to the tensor analyzing power in elastic pd backward scattering. PMID- 9952527 TI - Ground-state photoneutron reactions in 14C. PMID- 9952526 TI - Neutron-proton radiative capture cross section at Tn PMID- 9952528 TI - Resonating group Faddeev approach to deuteron-alpha scattering. PMID- 9952529 TI - Decays of high-lying states in 12C. PMID- 9952530 TI - Multiconfiguration resonating-group theory of the seven-nucleon system with realistic cluster wave functions. PMID- 9952532 TI - Coupled channel analysis of proton scattering from 40Ar. PMID- 9952531 TI - Measurement of the 158Tb electron-capture Q value. PMID- 9952533 TI - Microscopic analysis of complete 90Zr(p,n) spectra including the Delta isobar effect. PMID- 9952535 TI - Level structures of 61Co via the reaction 59Co(t,p)61Co. PMID- 9952534 TI - Optical model for low-energy neutrons on 60Ni. PMID- 9952536 TI - Anomalous absorption of neutron partial waves by the nuclear optical potential. PMID- 9952537 TI - High spin states in 99Tc. PMID- 9952538 TI - Uranium nuclear reactions at 900 MeV/nucleon. PMID- 9952539 TI - High-spin states in 157,158Er and 158,159Tm. PMID- 9952540 TI - Fast light particle emission in 20 MeV/nucleon 20Ne induced reactions. PMID- 9952541 TI - Collective structures in the odd-Z transitional nuclei 115,117I and 121,123Sb. PMID- 9952542 TI - Production of fast alpha particles in 20Ne+ 197Au collisions studied by counting the simultaneously emitted neutrons. PMID- 9952543 TI - New J pi =10(+) resonance in 16O PMID- 9952544 TI - Recoil of products from reactions of 20,22Ne with 93Nb at 100 and 142 MeV. PMID- 9952546 TI - Spin dependence of the Lambda N effective interaction. PMID- 9952545 TI - Nucleon-nucleon t-matrix interaction for scattering at intermediate energies. PMID- 9952547 TI - ( pi, pi N) reactions in 48Ca. PMID- 9952548 TI - Measurements of the spin-rotation parameters for parrowd-->parrowd elastic scattering at 496, 647, and 800 MeV. PMID- 9952549 TI - Triple-differential cross sections to discrete states in the 16O( pi +,2p)14N reaction. PMID- 9952551 TI - Analytic distorted wave approximation for pion scattering from nuclei. PMID- 9952550 TI - Relativistic and nonrelativistic impulse approximation descriptions of 300-1000 MeV proton + nucleus elastic scattering. PMID- 9952552 TI - g factor of 41+ states in the N=82 isotones 136Xe and 138Ba. PMID- 9952553 TI - Electron capture decay rate of 50V. PMID- 9952554 TI - Energy level measurements in 158Gd: An investigation of a possible neutrino balance. PMID- 9952555 TI - Decay of mass-separated 199Pom and 199Pog. PMID- 9952557 TI - Six quark cluster effects and binding energy differences between mirror nuclei. PMID- 9952556 TI - Directional correlation measurements for gamma transitions in 127Te. PMID- 9952558 TI - Dynamics of the nuclear one-body density: Small amplitude regime. PMID- 9952559 TI - Rotational structure of highly deformed 99Y: Decay of 99Sr. PMID- 9952560 TI - Rotational structure of highly deformed 99Y: Particle-rotor model calculations. PMID- 9952561 TI - Form factors and the s-wave component of the two-pion-exchange three-nucleon potential. PMID- 9952562 TI - Two-step processes in the population of the 22+ state via the 197Au(d,3He)196Pt reaction. PMID- 9952563 TI - Multinucleon transfer in the reaction 12C(p, 6Li)7Be at Ep =40.3 MeV. PMID- 9952564 TI - Evidence for multistep processes in proton capture reactions. PMID- 9952566 TI - Half-life of 71Ge. PMID- 9952565 TI - Low energy antiproton nuclear absorption cross sections. PMID- 9952567 TI - Partitioning of nuclei. PMID- 9952569 TI - Anomalous M3 moment in 39K as a test of nuclear structure. PMID- 9952568 TI - Phase ambiguities in the O(6) limit of the interacting boson model. PMID- 9952570 TI - Analyzing power as a probe for clarifying nuclear reaction mechanisms: Calculation of the two-step unbound channel contribution. PMID- 9952571 TI - Interaction of relativistic helium projectile fragments in nuclear emulsions. PMID- 9952572 TI - Isospin composition of giant resonances and asymmetries in pi + compared to pi - inelastic scattering. PMID- 9952573 TI - Insensitivity of weak interaction amplitudes to relativistic nuclear dynamics. PMID- 9952574 TI - Inelastic electron scattering form factors involving the second excited 2(+) levels in the nuclei 48Ti and 50Cr. PMID- 9952575 TI - 12C PMID- 9952576 TI - Equivalent local Dirac potentials. PMID- 9952577 TI - Nucleon scattering from 34S and the relative sign of neutron and proton transition matrix elements for the (0-->22+) transition. PMID- 9952578 TI - Testing the validity of statistical models of fission fragment angular distributions. PMID- 9952579 TI - Coalescence of complex fragments. PMID- 9952580 TI - 4He D-state effects in the 2H(d PMID- 9952582 TI - Natural parity states of 20Ne for 12 d pi + and pi d --> pi d. PMID- 9952662 TI - K+ mesons as a probe of the nuclear interior. PMID- 9952661 TI - Coulomb effects and charge symmetry breaking for the A=4 hypernuclei. PMID- 9952664 TI - Recoil effects in the relativistically corrected impulse approximation. PMID- 9952663 TI - Limits on the neutron-antineutron oscillation time from the stability of nuclei. PMID- 9952665 TI - Relativistic (Dirac equation) effects in microscopic elastic scattering calculations. PMID- 9952666 TI - Pion single charge exchange on 7Li at low energies. PMID- 9952667 TI - Method for observation of neutrinos and antineutrinos. PMID- 9952668 TI - Nucleon-Dirac potentials from quark models. PMID- 9952670 TI - beta + decay of 47Cr. PMID- 9952669 TI - E0 transitions in 82Kr. PMID- 9952671 TI - Search for the decay of 180Tam. PMID- 9952672 TI - Weak branches in 42Sc, 35Ar, and 27Si beta + decay. PMID- 9952674 TI - beta - decay of 158Tb. PMID- 9952673 TI - Observation of the beta decay of 180Hfm. PMID- 9952675 TI - Stable vortex excitations in rotating nuclei. PMID- 9952676 TI - Physical boson basis states in the boson expansion theories. PMID- 9952677 TI - 10 PMID- 9952679 TI - Particle-hole symmetry in the interacting-boson model: Fermion and boson aspects. PMID- 9952678 TI - Relationship between effective and realistic interactions in 6Li. PMID- 9952681 TI - Systematics of fission fragment total kinetic energy release. PMID- 9952680 TI - Different bases in the SU(3) limit of the interacting-boson model. PMID- 9952682 TI - Probing the microstructure of the giant dipole resonance in 208Pb. PMID- 9952684 TI - Higher nodal states of alpha+ 15N cluster structure in 19F. PMID- 9952683 TI - Depletion of light cluster production in 1 GeV proton-nucleus collisions. PMID- 9952685 TI - Measurement of pion-induced deuteron breakup at 150 MeV. PMID- 9952686 TI - Low-lying proton resonances of spin 9/2 in 51Mn and 53Mn. PMID- 9952687 TI - Large-angle proton-nucleus scattering shows no evidence for intermediate Delta states. PMID- 9952688 TI - Entrance channel dependence of back angle yields: Orbiting in 24Mg PMID- 9952689 TI - Angular correlations in the beta-delayed two-proton decay of 22Al. PMID- 9952690 TI - Inelastic scattering of pions on 12C at 800 MeV/c. PMID- 9952692 TI - NN potential with separable core from MIT bag model. PMID- 9952691 TI - Extension of the Beg-Agassi-Gal theorem to virtual particles. PMID- 9952694 TI - Erratum: Rotating toroidal nuclei in heavy-ion reactions PMID- 9952695 TI - Observation of N and M orbital-electron capture in the decay of 163Ho. PMID- 9952693 TI - Ground state binding energies of hypernuclei. PMID- 9952696 TI - Asymmetric neutron emission in 14N PMID- 9952697 TI - Capture of polarized protons by 12C and the interference of compound and direct reaction mechanisms near Ep PMID- 9952698 TI - Inelastic scattering of 65 MeV protons from 12C, 24Mg, 28Si, and 32S. PMID- 9952699 TI - 16O( gamma,p)15N reaction for E gamma =100-400 MeV. PMID- 9952700 TI - Giant quadrupole and monopole resonances in 28Si. PMID- 9952701 TI - 3Hearrow(p,p)3He analyzing powers between 25 and 35 MeV. PMID- 9952702 TI - Search for isovector magnetic quadrupole strength and spin-isospin correlations in 20Ne. PMID- 9952703 TI - 9Be(p,p alpha ) 5He cluster knockout reaction with 150 MeV polarized protons. PMID- 9952704 TI - Polarization transfer in n-p scattering at 50 MeV. PMID- 9952705 TI - Gamow-Teller matrix elements from the 11B(p,n)11C reaction at Ep PMID- 9952706 TI - Spectroscopy of the 5(-), 6(-), and PMID- 9952707 TI - Inelastic electron scattering from 48Ca. PMID- 9952708 TI - Analysis of giant resonances in proton, 3He, and alpha scattering and the spin flip strength in 208Pb. PMID- 9952709 TI - Coulomb excitation of 165Ho. PMID- 9952710 TI - Numerical simulation of medium energy heavy ion reactions. PMID- 9952712 TI - Charge exchange, scattering, and transfer reactions for 9Be+6Li and analysis of 14C(6Li,6He). PMID- 9952711 TI - Hydrodynamic phase in cylindrically symmetric ultrarelativistic heavy ion collisions. PMID- 9952713 TI - Spin distribution of the compound nucleus in heavy ion reactions at near-barrier energies. PMID- 9952714 TI - Excitation functions for production of heavy actinides from interactions of 40Ca and 48Ca ions with 248Cm. PMID- 9952715 TI - Vlasov-Uehling-Uhlenbeck theory of medium energy heavy ion reactions: Role of mean field dynamics and two body collisions. PMID- 9952716 TI - Energy dependence of the cross sections for the 24Mg(16O,12C)28Si(g.s.) reaction. PMID- 9952717 TI - Fragmentation of hot classical drops. PMID- 9952718 TI - Incomplete fusion calculations in the 27Al(16O,xy) reaction at 65, 77, and 87.4 MeV bombarding energies. PMID- 9952719 TI - Spontaneous fission of rutherfordium isotopes. PMID- 9952720 TI - Surface effects on the isovector spin response induced by high energy protons. PMID- 9952721 TI - Polarization observables in pi d--> pi d and pp--> pi d and the NN- pi NN equations. PMID- 9952722 TI - (N, Delta ) reaction in the bag model. PMID- 9952724 TI - Reaction p PMID- 9952723 TI - Reaction 2H(p,d pi +)n at 506 MeV. PMID- 9952725 TI - Meson exchange calculation of the p PMID- 9952726 TI - Dynamical model for pion photoproduction in the Delta region. PMID- 9952727 TI - Half-life of 241Pu. PMID- 9952728 TI - End-point energy of 3H beta decay. PMID- 9952729 TI - Calculation of the 48Ca( beta -)48Sc decay rate. PMID- 9952731 TI - Thermal properties of 16O and 40Ca with a realistic effective Hamiltonian. PMID- 9952730 TI - Spectroscopy of the platinum isotopes and the dynamical supersymmetry U(6/12). PMID- 9952733 TI - Multi-quark compound states and the 3He charge form factor. PMID- 9952732 TI - 6Li--> alpha PMID- 9952734 TI - Generating function for angular momentum multiplicities. PMID- 9952735 TI - Radiochemical measurements of 200-MeV proton-induced fission of 133Cs. PMID- 9952736 TI - Improved limits on the double beta decay half-lives of 50Cr, 64Zn, 92Mo, and 96Ru. PMID- 9952737 TI - Additional beta-delayed protons from the Tz=-3/2 nuclei 21Mg, 25Si, 29S, and 41Ti. PMID- 9952738 TI - Quark effects in the charge distribution of 208Pb. PMID- 9952740 TI - Derivation of the eigenstates of Hermitian boson expansion theory from results of non-Hermitian theory. PMID- 9952739 TI - Consistency of polarization corrections to the S-wave isovector strength in the pion-nucleus optical potential. PMID- 9952741 TI - Isovector admixtures in the isoscalar giant quadrupole resonance in 208Pb. PMID- 9952743 TI - Comparison of magnetic dipole excitations in the f7/2 shell region with the new collective excitations in 156Gd. PMID- 9952742 TI - Tensor analyzing powers T20( theta ) and T22( theta ) in the 2H(darrow, gamma ) 4He reaction. PMID- 9952744 TI - Charge asymmetry effects in pi *d elastic scattering at 180 MeV. PMID- 9952745 TI - Double K-shell ionization in electron capture decay. PMID- 9952746 TI - Systematics in the volume integrals of the imaginary part of the light ion optical potentials. PMID- 9952747 TI - Influence of neck formation on heavy ion subbarrier fusion. PMID- 9952748 TI - Direct surface transfer reactions induced by a 1102 MeV40Ar beam on 68Zn target nucleus. PMID- 9952749 TI - Erratum: Equivalent local Dirac potentials PMID- 9952750 TI - Observation of parity doublets in 219Ac. PMID- 9952751 TI - Sub-barrier fusion of 16O with 16,18O. PMID- 9952752 TI - Radioactive decay of 232U by 24Ne emission. PMID- 9952753 TI - Interpretation of the angular distribution of the 4He( pi -,n)3H reaction based on the Delta -hole model. PMID- 9952754 TI - Evidence for an underlying SU(3) structure near neutron number N=104. PMID- 9952755 TI - Specific distortion effects in the five-nucleon system. PMID- 9952756 TI - Spin isovector responses in finite nuclei. PMID- 9952757 TI - Separable Ernst-Shakin-Thaler expansions of local potentials. PMID- 9952758 TI - Current conservation and the transverse electric multipole field. PMID- 9952759 TI - 2H(d, gamma ) 4He reaction at low energies. PMID- 9952760 TI - Test of Fermi gas model predictions of level density in 137Xe. PMID- 9952762 TI - Magnetic dipole excitations in the N=28 isotones 50Ti, 52Cr, and 54Fe. PMID- 9952761 TI - Cross sections and analyzing powers for quenched spin excitations in 40,48Ca at Ep PMID- 9952763 TI - Transfer in the light Hg isotopes and the U(6/12) models. PMID- 9952764 TI - 14N(7Li,p)20F: Ex=4.5-9.0 MeV. PMID- 9952766 TI - High-spin gamma -ray spectroscopy in Z=83 isotopes: 199,201Bi. PMID- 9952765 TI - Elastic and inelastic scattering of 12C PMID- 9952768 TI - Coagulation of the quark-gluon plasma in nn PMID- 9952767 TI - Complete fusion and quasifission in reactions between heavy ions. PMID- 9952769 TI - Deformation effects in the heavy ion quarter-point angle. PMID- 9952771 TI - Charge symmetry violation in the structure of the 3H-3He system. PMID- 9952770 TI - Alpha transfer mechanism in heavy-ion reactions. PMID- 9952772 TI - Pion scattering on aligned 165Ho. PMID- 9952774 TI - Mechanism of 3He( pi -,pn) reaction. PMID- 9952773 TI - Transport theory for inclusive pion reactions and mean proton momentum for ( pi,p). PMID- 9952776 TI - K PMID- 9952775 TI - Production mechanism of backward energetic protons studied from two-particle correlations in 800 MeV proton-nucleus collisions. PMID- 9952777 TI - Measurement of the 16N(2(-),g.s.)--> 16O(0 (+),g.s.)+e PMID- 9952779 TI - Upper limit on T nonconserving tensor couplings in nuclear beta decay. PMID- 9952778 TI - Decay of 2.22-sec 1 5646Ba90 to levels of odd-odd 1 5746La89. PMID- 9952780 TI - Experimental test of time reversal invariance using beta-polarization-gamma angular correlations in beta decay. PMID- 9952782 TI - Simultaneous electromagnetic enhancement of nuclear beta decay and isomeric transitions. PMID- 9952781 TI - Beta decay of the new isotopes 52K, 52Ca, and 52Sc; a test of the shell model far from stability. PMID- 9952784 TI - Excited states of 4He. PMID- 9952783 TI - Cluster picture of 7Li. PMID- 9952786 TI - Convergence of Faddeev partial-wave series for triton ground state. PMID- 9952785 TI - Simple model for backbending. PMID- 9952787 TI - Multiconfiguration microscopic study of alpha + 14C molecular states. PMID- 9952789 TI - Isoscalar giant monopole in a macroscopic-microscopic approach. PMID- 9952788 TI - Three-nucleon bound-state collapse with Tabakin potentials. PMID- 9952790 TI - E2 strength of the lowest resonance in 6Li( alpha, gamma ): Collective effects in the 1p shell. PMID- 9952791 TI - Misconceptions regarding spin 3/2. PMID- 9952793 TI - Hypertriton and hyperspherical harmonics. PMID- 9952792 TI - Equivalent local potentials for nucleon-alpha scattering. PMID- 9952794 TI - Energy and density dependence of the isovector tensor interaction. PMID- 9952795 TI - Signature to detect the isovector giant quadrupole resonance. PMID- 9952796 TI - Widths of the 6.92 and 7.12 MeV levels in 16O and the influence of the effective temperature. PMID- 9952797 TI - Resonant states in momentum representation. PMID- 9952799 TI - Probing heavy ion collisions with bremsstrahlung. PMID- 9952800 TI - Hermitian folded-diagram potentials in nucleon-nucleon scattering. PMID- 9952798 TI - Photoexcitation mechanisms and the fission process of 209Bi from threshold to the Delta region. PMID- 9952801 TI - 4He(d,p)n4He reaction at low bombarding energies. PMID- 9952802 TI - Thermal neutron capture gamma rays from sulfur isotopes: Experiment and theory. PMID- 9952803 TI - Method of continued fractions for on- and off-shell t matrix of local and nonlocal potentials. PMID- 9952805 TI - Nonradiative versus radiative nuclear excitation in the positron-K-electron annihilation. PMID- 9952804 TI - Elastic scattering of polarized neutrons on 16O, 59Co, and Pb at 23 MeV. PMID- 9952806 TI - Measurement of the cross sections for the 232Th(n,2n)231Th reaction in the 6.745 to 10.450 MeV energy range. PMID- 9952807 TI - Coincident neutron-proton emission from proton bombardment of 87Sr and 91Zr. PMID- 9952809 TI - Microscopic calculation of the imaginary Lane isospin potential W1. PMID- 9952808 TI - Core polarization in inelastic scattering to 52Cr(21+). PMID- 9952810 TI - Composite particles and entropy production in relativistic nuclear collisions. PMID- 9952811 TI - Direct reaction description of sub- and above-barrier fusion of heavy ions. PMID- 9952812 TI - Level structure of 215Fr. PMID- 9952813 TI - Light-particle-complex-fragment coincidence cross sections from intermediate energy nucleus-nucleus collisions. PMID- 9952814 TI - Anomalous projectile fragments as nuclear molecules. PMID- 9952815 TI - Time-dependent Hartree-Fock calculations of 4He PMID- 9952816 TI - Nuclear-charge distribution near symmetry for thermal-neutron-induced fission of 235U. PMID- 9952817 TI - Angular distributions in heavy-ion-induced fission. PMID- 9952818 TI - Linear momentum transfer in 292-MeV 20Ne-induced fission of 165Ho, 181Ta, 197Au, 209Bi, and 238U. PMID- 9952819 TI - Simple parametrization of the pi -N amplitude. PMID- 9952820 TI - Spin observables in elastic proton scattering. PMID- 9952822 TI - Effects of medium-modified form factors in quasielastic electron scattering from 12C. PMID- 9952821 TI - Proton-nucleon spin-rotation and -depolarization parameters at 800 MeV. PMID- 9952823 TI - Inclusive measurement of (p, pi -xn) double charge exchange reactions on bismuth from threshold to 800 MeV. PMID- 9952824 TI - Relativistic effects in the neutron-deuteron scattering lengths. PMID- 9952825 TI - Meson theoretical basis for Dirac impulse approximation. PMID- 9952826 TI - Decays of 117Xe--> PMID- 9952827 TI - Collective M1 states in the classical limit of the neutron-proton interacting boson model. PMID- 9952828 TI - Treatment of pairing correlations based on the equations of motion for zero coupled pair operators. PMID- 9952829 TI - Polarized-proton-induced pion production on sup10B at 200, 225, 250, and 260 MeV incident energies. PMID- 9952830 TI - Excitation function of the sup58Ni(n,d)sup57Co reaction near its threshold. PMID- 9952831 TI - Measurement of the backward-to-90 degrees neutron-proton elastic cross section ratio between 40 and 75 MeV. PMID- 9952832 TI - Identification of the yrast decay scheme of sup86Y. PMID- 9952833 TI - Experimental evidence against the proposed band based on a shape isomer in sup32S. PMID- 9952835 TI - Electron scattering transverse sum rule: Tentative comparison with experimental data. PMID- 9952834 TI - Equivalent local potentials from nonlocal separable ones. PMID- 9952837 TI - Hypernucleus production in heavy-ion collisions. PMID- 9952836 TI - Magnetic quadrupole strength in sup12C. PMID- 9952838 TI - Semiclassical methods and the summation of the scattering partial wave series. PMID- 9952840 TI - Reply to "Role of pion absorption on quasi-deuterons in sup12C( pi sup+,2p)" PMID- 9952839 TI - Role of pion absorption on quasi-deuterons in sup12C( pi sup+,2p). PMID- 9952841 TI - Comparison between semiclassical and classical descriptions of the collective M1 mode in the interacting boson model. PMID- 9952842 TI - Determination of two-nucleon spectroscopic amplitudes from (d, alpha ) analyzing powers. PMID- 9952843 TI - Single-particle states in sup149Er and sup149Ho, and the effect of the Z=64 closure. PMID- 9952844 TI - Further evidence for a stiff nuclear equation of state from a transverse-momentum analysis of Ar(1800 MeV/nucleon) + KCl. PMID- 9952846 TI - Nsup model for the reaction sup12C(p, pi sup-)sup13Osubg.s. far above the 33 resonance. PMID- 9952845 TI - Nonanalog pion double charge exchange through Delta sub33-nucleon interaction. PMID- 9952847 TI - Energy average of the scattering matrix in picket-fence models. PMID- 9952849 TI - Gamma-ray energies from the reaction 35Cl(n, gamma ). PMID- 9952848 TI - Photoproton decay of the E1 giant resonance in 19F. PMID- 9952851 TI - Photoneutron cross sections for 14C. PMID- 9952850 TI - Neutron capture by 31P. PMID- 9952852 TI - Identification of new excited levels in 28Si through the 27Al(d,n)28Si reaction. PMID- 9952853 TI - Four-nucleon scattering in the K-matrix approach with improved treatment of the (2+2) channels. PMID- 9952856 TI - Fragmentation of the low-energy octupole resonance in 48Ca, 90Zr, and 208Pb. PMID- 9952855 TI - Neutron decay of the isoscalar giant resonance region in 90Zr. PMID- 9952854 TI - Single-particle effects in precompound reactions: Influence of the f7/2 shell closure. PMID- 9952857 TI - Equivalence of post and prior sum rules for inclusive breakup reactions. PMID- 9952859 TI - Direct measurement of the radiative tail in electron scattering from atomic nuclei. PMID- 9952858 TI - Multipole moments of 176Yb and 182W nuclei from inelastic scattering of 134 MeV protons. PMID- 9952860 TI - Mechanism of spin-dependent inelastic scattering in the 13C PMID- 9952862 TI - Reexamination of fission fragment angular distributions and the fission process: Formalism. PMID- 9952861 TI - Possibility of dynamical symmetry restoration in the Gaussian overlap approximation. PMID- 9952864 TI - Light-charged-particle emission in the spontaneous fission of 250Cf, 256Fm, and 257Fm. PMID- 9952863 TI - Reexamination of fission fragment angular distributions and the fission process: Analysis of data. PMID- 9952865 TI - Dynamical evaluation of pi d-dibaryon coupling parameters. PMID- 9952866 TI - Relativity and spin in one-, two-, and three-body systems. PMID- 9952867 TI - Theory of mesonic and dibaryonic excitations in the pi NN system: Derivation of pi NN scattering equations. PMID- 9952869 TI - Hypernuclear physics with electron beams: Exclusive and inclusive excitations. PMID- 9952868 TI - Isospin dependence of Pauli corrections to the pion-nucleus optical potential. PMID- 9952870 TI - Double excitation in high energy inelastic scattering. PMID- 9952871 TI - Intermediate isobar effects in a two-nucleon mechanism for (p, pi ). PMID- 9952872 TI - Atomic nuclei decay modes by spontaneous emission of heavy ions. PMID- 9952873 TI - Measurements of spin, magnetic moment, and electric quadrupole moment of 41.5 h 188Ir. PMID- 9952874 TI - Relation between the interacting boson-fermion approximation model and dynamical boson-fermion symmetries. PMID- 9952876 TI - Nuclear polarization in muonic 90Zr. PMID- 9952875 TI - Rotational properties of octupole deformed nuclei discussed within a simple model. PMID- 9952877 TI - Mass yield distribution for the interaction of silver with 300 GeV protons. PMID- 9952878 TI - Measurement of the neutron-proton total cross section in the 25-75-MeV range. PMID- 9952880 TI - Peaks in the low energy d PMID- 9952879 TI - Near-spherical band in 76Kr observed in the beta -decay of mass separated 76Rb. PMID- 9952881 TI - F-spin multiplets in collective nuclei. PMID- 9952883 TI - Structural changes at very high spins in Yb isotopes. PMID- 9952882 TI - Comparison of truncated shell model calculations in the laboratory and intrinsic systems. PMID- 9952885 TI - Suppression of elastic magnetic electron scattering form factors. PMID- 9952884 TI - Nuclear parity violation in gamma d--> pi PMID- 9952886 TI - Backward cross section in the generalized exciton model. PMID- 9952887 TI - Quark effects in nuclear longitudinal response functions. PMID- 9952888 TI - Microscopic description of the (p, pi -) continuum at intermediate proton energy. PMID- 9952890 TI - Sensitivity of the triton binding energy to the D-state probability in the deuteron. PMID- 9952889 TI - Importance of the energy-dependent geometry in the 16O PMID- 9952891 TI - Parametrizing the equation of state of cold and dense nuclear matter. PMID- 9952892 TI - Erratum: Measurement of the 158Tb electron-capture Q value PMID- 9952893 TI - Search for energy and target effects in anomalous projectile fragment production. PMID- 9952894 TI - Microscopic optical model analysis of nucleon scattering from light nuclei. PMID- 9952895 TI - Separable potentials from Gamow states. PMID- 9952896 TI - Reaction 2H(3He, gamma ) 5Li at center-of-mass energies between 25 and 60 keV. PMID- 9952898 TI - Parametrization of the coupled channels S matrix in the inelastic case. PMID- 9952897 TI - Test of the reduced width amplitude distribution from proton resonance studies. PMID- 9952899 TI - Cross sections for He, Li, and Be isotopes produced in the alpha + alpha reaction at 198.4 MeV. PMID- 9952900 TI - States of 38S from the 36S(t,p)38S reaction. PMID- 9952901 TI - Inclusive 150-MeV-proton-induced spectra at forward angles. PMID- 9952902 TI - Sturmian projection and an L2 discretization of three-body continuum effects. PMID- 9952903 TI - 198,199,200,201,202,204Hg(n, gamma ) cross sections and the termination of s process nucleosynthesis. PMID- 9952904 TI - (t,3He) reactions on 40,42,44Ca, 46,48,50Ti, 54Cr, and 54Fe. PMID- 9952906 TI - Microscopic approach to the alpha-particle-nucleus optical potential. PMID- 9952905 TI - (e,p) and (e, alpha ) reactions in 90Zr and 92Zr. PMID- 9952907 TI - Shell model calculation for the 71Ga( nu,e-)71Ge solar neutrino detector. PMID- 9952909 TI - Gamma rays in 148Sm from the decay of 148Eu and the 146Nd( alpha,2n gamma ) reaction. PMID- 9952908 TI - Determination of the pi 1g9/2 orbit size in 88Sr, 90Zr, and 92Mo from inelastic electron scattering. PMID- 9952910 TI - Inelastic proton scattering to the 3(-) and 1(+) states in 50Ti, 52Cr, and 54Fe. PMID- 9952911 TI - "Stripping" reaction in heavy ion projectile dissociation: Extended Serber model. PMID- 9952912 TI - 21Ne from 12C PMID- 9952913 TI - Resonances in 13C(13C, alpha )22Ne. PMID- 9952914 TI - Statistical analysis of 13C(13C, alpha )22Ne. PMID- 9952915 TI - 28Si PMID- 9952916 TI - Nuclear temperatures in the reaction of 14N with Ag at 35 MeV/nucleon. PMID- 9952917 TI - Potential sensitivity in projectile excitation for 7Li PMID- 9952918 TI - Transfer and breakup processes in reactions of 11- and 17-MeV/nucleon 20Ne PMID- 9952919 TI - Unambiguous phase-shift analysis of the 12C(12C, alpha 0)20Ne reaction at Coulomb barrier energies. PMID- 9952920 TI - Proton-induced fission of 232Th and Ir: Exciton model calculations. PMID- 9952921 TI - Large angle pi d scattering in the region of the (3,3) resonance. PMID- 9952922 TI - Dispersive effects in pion-nucleus scattering. PMID- 9952923 TI - Relativistic treatment of the spin difference functions in inelastic proton nucleus scattering. PMID- 9952925 TI - 3He(p,2p)d and 3He(p,pd)p reactions at large recoil momenta. PMID- 9952924 TI - Noncoplanar geometry for detecting nuclear renormalization effects in exclusive ( pi, pi N) reactions. PMID- 9952927 TI - Diffraction theory analysis of pion elastic scattering from the calcium isotopes. PMID- 9952926 TI - Pion production near mid-rapidity in high-energy heavy-ion collisions. PMID- 9952928 TI - Isospin effect in pi * 14C elastic scattering at 50 MeV. PMID- 9952929 TI - Systematics of continuum pion double charge exchange on T=0 nuclei. PMID- 9952930 TI - 144Nd levels fed in beta decay of 144Pr isomers. PMID- 9952932 TI - Longitudinal polarization of positrons in 22Na decay. PMID- 9952931 TI - Inner bremsstrahlung accompanying beta decay of 147Pm. PMID- 9952933 TI - Band structure in the N=88 isotones 149Pm, 151Eu, and 153Tb. PMID- 9952934 TI - Thermal effects and the interplay between pairing and shape deformations. PMID- 9952936 TI - Brueckner-Bethe and variational calculations of nuclear matter. PMID- 9952935 TI - Symmetry-conserving higher-order interaction terms in the interacting boson model. PMID- 9952937 TI - Interacting boson model with surface delta interaction between nucleons. PMID- 9952939 TI - Structure of the actinides by the interacting boson model. PMID- 9952938 TI - Neutron-proton multiplets in odd-odd 106-116In nuclei. PMID- 9952940 TI - Structure in the fusion yield for 32S PMID- 9952941 TI - Energy dependence of the 7Li(p,d)6Li reaction. PMID- 9952943 TI - Variational calculations with correlated basis functions: Three-nucleon and three alpha-particle systems. PMID- 9952942 TI - Diffraction analysis of pion-elastic scattering from 40Ar. PMID- 9952944 TI - Entrance-channel effects on the average angular momentum of compound nuclei produced in fusion reactions. PMID- 9952945 TI - Black body description of antiproton-nucleus scattering. PMID- 9952946 TI - Elimination of the linear energy-dependence of nonlocal optical potentials. PMID- 9952947 TI - Double isobaric analog resonance in 208Po and the isobaric multiplet mass equation. PMID- 9952948 TI - Erratum: Six quark cluster effects and binding energy differences between mirror nuclei PMID- 9952949 TI - Erratum: Neutron spectra and level density parameters from the 16O+12C fusion reaction PMID- 9952950 TI - pi 0 photoproduction on scalar-isoscalar nuclei near threshold. PMID- 9952951 TI - Observation of high energy gamma rays in intermediate energy nucleus-nucleus collisions. PMID- 9952953 TI - Incompressibility of neutron-rich nuclear matter. PMID- 9952952 TI - Single-particle 2d5/2 strength in the 48Ca PMID- 9952955 TI - Surface effects in the exciton model of preequilibrium nuclear reactions. PMID- 9952954 TI - Shell-model analysis of high-resolution data for elastic and inelastic electron scattering on 19F. PMID- 9952956 TI - Microscopic analysis of t PMID- 9952958 TI - Nucleon-nucleon interaction in the quark compound bag model. PMID- 9952957 TI - Elastic photon scattering from carbon and calcium and its interpretation. PMID- 9952959 TI - Relativistic effects in the sum rules for the d( gamma, p)n reaction. PMID- 9952960 TI - Coherent contributions of charge-dependent forces to the spreading width of the analog of 49Ca. PMID- 9952961 TI - Predictions of elastic alpha particle scattering from theoretical nuclear densities. PMID- 9952963 TI - Optical potentials from the scattering cross section by inversion. PMID- 9952962 TI - Recoil range distributions of residues from alpha + 59Co reactions. PMID- 9952964 TI - Subthreshold pion production. PMID- 9952965 TI - Nuclear structure in 95,97Ru nuclei. PMID- 9952966 TI - Pion-helium potential by inverse scattering method. PMID- 9952967 TI - (3He,t) reaction in the Delta -isobar region. PMID- 9952968 TI - Separable model for the antinucleon-nucleon elastic and annihilation interaction. PMID- 9952969 TI - Nuclei containing an antinucleon. PMID- 9952970 TI - Inelastic scattering of pi + and pi - mesons from 3He and 4He at energies of 350, 400, and 475 MeV. PMID- 9952971 TI - Excitation functions for the production of 18F and 24Na from Al and Si with fast pions. PMID- 9952972 TI - Final state interactions and relativistic effects in the (e PMID- 9952973 TI - Independent isomer yield ratio of 90Rb from thermal neutron fission of 235U. PMID- 9952974 TI - Measurement of three protons in coincidence following absorption of 228 MeV pi + in carbon. PMID- 9952975 TI - Electromagnetic pion pair current from quark models. PMID- 9952976 TI - Decays of 101Rhm and 101Rhg. PMID- 9952977 TI - Search for the beta - decay of 48Ca. PMID- 9952978 TI - Nuclear structure and double beta decay: Two neutrino mode. PMID- 9952979 TI - Temperature dependence of collective states in hot nuclei. PMID- 9952980 TI - Charge independence breaking and the triton binding energy. PMID- 9952981 TI - Quenching of spin-flip quadrupole transitions. PMID- 9952983 TI - Hybrid mass relations. PMID- 9952982 TI - Calculation of nuclear level density from an equation of state. PMID- 9952984 TI - Comparison of Lanczos methods and moment methods in calculating nuclear level densities. PMID- 9952985 TI - U(5) x SU(2) limits of the interacting boson fermion model, their associated supersymmetries, and their application to 76Se and 75As. PMID- 9952987 TI - Radiative deuteron capture into the secondary doorway state of 13C. PMID- 9952986 TI - Electromagnetic transitions in 205Hg. PMID- 9952988 TI - Modified separable representation of the Paris nucleon-nucleon potential in the 1S0 and 3P0 states. PMID- 9952989 TI - 58Ni+64Ni subbarrier fusion cross section. PMID- 9952991 TI - E4 systematics and the interacting boson model. PMID- 9952990 TI - Cluster configurations in 7Li. PMID- 9952992 TI - Channel coupling effects in subbarrier fusion of oxygen with oxygen. PMID- 9952993 TI - Direct reaction description of complete fusion above barrier. PMID- 9952994 TI - Sawtooth curve of neutron multiplicity. PMID- 9952996 TI - Fragmentation instabilities in nuclear systems. PMID- 9952995 TI - Excitation energy of the collective M1 mode in the classical limit of the neutron proton interacting boson model. PMID- 9952997 TI - Erratum: Dynamics of the nuclear one-body density: Small amplitude regime PMID- 9952998 TI - First observation of the d+d--> 4He+ eta 0 reaction. PMID- 9953000 TI - Inclusive angular distribution of alpha and Li fragments produced in Fe-C and Fe Pb collisions at 1.88 GeV/nucleon. PMID- 9952999 TI - Detection of heavy-ion reaction products in bound excited states. PMID- 9953001 TI - Possible hydrogen-like structure for giant resonances in nuclei. PMID- 9953002 TI - 17O(p PMID- 9953004 TI - Collective excitations of 194Pt in low energy neutron scattering. PMID- 9953005 TI - Linear momentum transfer in 40-150 MeV proton-induced reactions with 238U. PMID- 9953003 TI - 2H, 3,4He(p PMID- 9953006 TI - Radiative muon absorption in calcium. PMID- 9953007 TI - Multiple Coulomb excitation of the transitional nucleus 82Kr. PMID- 9953008 TI - Momentum balance for the incomplete fusion of 16O+40Ca. PMID- 9953009 TI - Gamma-ray multiplicity distribution associated with massive transfer. PMID- 9953010 TI - Elastic and inelastic scattering of uranium ions by holmium, gold, and bismuth targets. PMID- 9953012 TI - Optical model plus resonance analysis of 12C+12C elastic scattering. PMID- 9953011 TI - Alpha transfer reaction 16O(12C,8Beg.s.)Ne: Key process in the 12C(16O, alpha ) reaction. PMID- 9953013 TI - Neutron emission in inelastic reactions of 12C+ 158Gd and 20Ne+ 150Nd. PMID- 9953014 TI - Fusion reactions between 32S and 24,25,26Mg in the energy region Elab PMID- 9953015 TI - Approach to the limits for massive energy and spin deposition into a composite nucleus. PMID- 9953016 TI - Entropy evolution in heavy ion collision. PMID- 9953017 TI - Heavy residues following 5-10 MeV/nucleon 12C- and 14N- induced reactions on Sm and Pr targets. PMID- 9953018 TI - Phenomenological model for 6Li form factor in terms of multi-quark-cluster configurations. PMID- 9953019 TI - Separable potentials for relativistic three-body calculations of the NNN, NN pi, N pi pi, and pi pi pi systems. PMID- 9953020 TI - Measurements of the E2 resonance effect in pionic atoms. PMID- 9953021 TI - Spin observables in quasi-elastic proton-nucleus scattering near 1 GeV. PMID- 9953022 TI - General Lorentz-invariant representation of NN scattering amplitudes. PMID- 9953024 TI - Relativistic treatment of spin observables in the excitation of the 1(+) T=0 state in 12C. PMID- 9953023 TI - Kaon photoproduction operator for use in nuclear physics. PMID- 9953025 TI - Beta-delayed proton decays of 27P and 31Cl: Gamow-Teller decays with large Q values. PMID- 9953026 TI - Nuclear magnetic resonance on oriented 4.7 h 99Rhm, 4.3 d 101Rhm, and 2.9 d 97Ru after recoil implantation into Fe. PMID- 9953027 TI - Beta asymmetries in the decay of polarized 56Co. PMID- 9953028 TI - Double proton decay and H-H PMID- 9953030 TI - Mirror potentials and the fermion problem. PMID- 9953029 TI - Mixed-symmetry interpretation of some low-lying bands in deformed nuclei. PMID- 9953031 TI - Spectroscopic properties of highly excited states. PMID- 9953032 TI - Application of the Kishimoto-Tamura boson expansion theory to a single-j shell model. PMID- 9953033 TI - Rotational model with Coriolis mixing applied to the structure of stretched states. PMID- 9953035 TI - d3/2 1p PMID- 9953034 TI - Search for superheavy elements using the 48Ca+254Esg reaction. PMID- 9953036 TI - Measurements of neutron-deuteron elastic and charge exchange scattering. PMID- 9953037 TI - F-spin multiplets of nuclei and their relation to U(12). PMID- 9953038 TI - Volume integrals of optical potentials for light composite projectiles. PMID- 9953039 TI - Inadequacy of four-particle tests of Dyson boson mapping. PMID- 9953040 TI - Mesonic atoms from heavy-ion collisions. PMID- 9953042 TI - Applicability of transport theory of gases to the description of excited nuclear matter. PMID- 9953041 TI - WKB treatment of a simple two-dimensional fission model. PMID- 9953043 TI - Erratum: Complete fusion and quasifission in reactions between heavy ions PMID- 9953045 TI - Direct neutron decay of the giant quadrupole resonance in 92Zr and its particle hole structure. PMID- 9953044 TI - Two-step processes in the quasi-free (e,e'p) reaction. PMID- 9953046 TI - Nuclear alignment: Implications for the decay of the quantum-electrodynamic vacuum. PMID- 9953047 TI - Nucleon-deuteron scattering based on meson-exchange nucleon-nucleon dynamics. PMID- 9953048 TI - Evidence for nonstatistical fluctuations in nucleus-nucleus collisions at high energies. PMID- 9953050 TI - Ground state photoneutron reactions in 17O. PMID- 9953051 TI - Absolute cross section for the photodisintegration of deuterium. PMID- 9953049 TI - Coulomb energy systematics and the missing J pi =(1/2)+ state in 9B. PMID- 9953052 TI - Polarization asymmetry in the photodisintegration of the deuteron. PMID- 9953054 TI - In-beam gamma -ray spectroscopy of excited states in 141Pm. PMID- 9953053 TI - Relativistic effects and deuteron photodisintegration with polarized and unpolarized gamma rays. PMID- 9953055 TI - Emission of preformed alpha particles through a collective process in 150Sm(p, alpha ). PMID- 9953056 TI - Cross sections relevant to gamma-ray astronomy: Alpha-particle-induced reactions on 12C, 14N, and 16O nuclei. PMID- 9953057 TI - Coulomb excitation of 105Pd with protons. PMID- 9953058 TI - Level structure of 220Ra. PMID- 9953059 TI - In-beam gamma-ray spectroscopy of 82Sr. PMID- 9953060 TI - Search for heavy-ion resonances in the reactions 12C(20Ne, alpha ) and 12C(20Ne, 8Be). PMID- 9953061 TI - Description of light-ion collisions in the time-dependent cluster model. PMID- 9953062 TI - Multicoincidence study of fragmentation events at small angles from 20Ne induced reactions at 35 MeV/nucleon. PMID- 9953063 TI - Effect of shell structure on the nucleon transfer contribution to the imaginary part of the heavy ion optical potential. PMID- 9953064 TI - Photofission of 238U with neutron-capture gamma rays. PMID- 9953065 TI - Differential cross sections for p+d--> gamma +3He at intermediate energies. PMID- 9953066 TI - Delta excitations in heavy nuclei induced by (3He,t) and (p,n) reactions. PMID- 9953067 TI - Measurements of cross sections and analyzing powers for the inclusive pp-->pn pi PMID- 9953068 TI - Emission of 3He and 4He in reactions of 70- and 160-MeV pi +/- mesons with Ag. PMID- 9953069 TI - Validity of the coupled-channel method for the study of Delta excitation in intermediate-energy NN scattering. PMID- 9953070 TI - Probability current conservation imposed on nucleon knockout amplitudes. PMID- 9953072 TI - NN- pi NN equations and the chiral bag model. PMID- 9953071 TI - Continuum spectra for 165 MeV pion-nucleus single charge exchange. PMID- 9953073 TI - Three-particle equations for the pion-nucleon system. PMID- 9953075 TI - Double K-shell ionization accompanying the internal conversion of the 0.145-MeV transition in 141Pr. PMID- 9953076 TI - Variational formulation of nuclear fluid dynamics. PMID- 9953074 TI - Spontaneous 14C emission from 223Ra. PMID- 9953077 TI - Influence of the N=50 shell closure on mean square charge radii of strontium. PMID- 9953078 TI - Accuracy of the optimal subset approximation. PMID- 9953080 TI - Dynamical supersymmetry U(12/4) for boson-fermion systems. PMID- 9953079 TI - Trinucleon magnetic moments. PMID- 9953081 TI - Nuclear collective response calculated with realistic forces. PMID- 9953082 TI - Variational Monte Carlo calculation of 16O. PMID- 9953083 TI - Finite temperature effects and phase transitions in the pairing force problem: Variational approach. PMID- 9953084 TI - Nuclear structure of Sr, Zr, and Mo isotopes. PMID- 9953085 TI - Proton-neutron occupancies of spherical shells in the ground states of some doubly even 2p-1f shell nuclei. PMID- 9953086 TI - Boson expansion theory in the seniority scheme. PMID- 9953087 TI - Ground-state properties of nuclear matter using the Lambda approximations of the Green's function theory. PMID- 9953088 TI - Level structure and E2 strength from the 31P(n, gamma )32P reaction. PMID- 9953089 TI - Elastic scattering of 0.8 GeV protons from the non-zero-spin nuclei 13C and 14N. PMID- 9953090 TI - 3H(p PMID- 9953091 TI - Ground state M1 transition strength of the 1.115 MeV level in 65Cu. PMID- 9953092 TI - Search for a direct large-cluster-transfer process in the 12,13C(20Ne, alpha ) reaction. PMID- 9953094 TI - Analytic heavy-ion potentials. PMID- 9953093 TI - Off-shell properties of the Paris nucleon-nucleon potential and implications for few-body systems. PMID- 9953096 TI - Effects of the Pauli principle on the 16O PMID- 9953095 TI - Distribution of charge and matter in nuclei: Charge density difference of 206Pb and 205Tl. PMID- 9953097 TI - Neutrino reactions in 13C and the behavior of the axial current form factor. PMID- 9953098 TI - Effect of fission following incomplete fusion on the interpretation of fission fragment angular distributions in heavy-ion fusion reactions. PMID- 9953099 TI - Electric hexadecupole transition strength in 32S and shell-model predictions for E4 systematics in the sd shell. PMID- 9953101 TI - Sensitivity of beta - gamma circular polarization measurements to a possible right-handed current presence in the weak interaction. PMID- 9953100 TI - Coulomb corrections to alpha - alpha phase shifts. PMID- 9953102 TI - Simple estimates of excitation energy sharing between heavy and light fragments in heavy-ion reactions. PMID- 9953103 TI - Heavy cluster decay of trans-zirconium "stable" nuclides. PMID- 9953105 TI - Absorption cross sections and the use of complex potentials in coupled-channels models. PMID- 9953104 TI - Effect of the nuclear surface on a propagating density pulse. PMID- 9953106 TI - Comment on "Negative-parity alpha clusters in 19F" PMID- 9953107 TI - Reply to "Comment on 'Negative-parity alpha clusters in 19F' " PMID- 9953108 TI - Large-angle elastic scattering of pi + and pi - from 16O at 114 MeV. PMID- 9953109 TI - g bosons and the third 4(+) state in 192Os. PMID- 9953110 TI - Search for admixture of heavy neutrinos with masses between 5 and 55 keV. PMID- 9953111 TI - Structure of high-spin proton states in 208Pb. PMID- 9953112 TI - Measurements of elastic neutron scattering from sup12C and 32S at 30.3 and 40.3 MeV: Limits on charge symmetry breaking in the nuclear mean field. PMID- 9953113 TI - Compound nucleus fluctuation cross section in the intermediate coupling regime Gamma -bar/D-bar PMID- 9953114 TI - Energy dependence of deformation parameters in the 12C(p PMID- 9953115 TI - Energy dependence of 24Mg(p PMID- 9953116 TI - Proton stripping to 6(-) stretched states of 26Al. PMID- 9953117 TI - Nuclear matter density effects in monopole transitions. PMID- 9953118 TI - Two-body photodisintegration of 4He in the 100-360 MeV region. PMID- 9953119 TI - Three-body model of the optical potential for particle-nucleus scattering. PMID- 9953120 TI - Neutron total cross section in Ca and Fe at 35.3, 40.3, and 50.4 MeV. PMID- 9953121 TI - 74,76,78,80,82Se by inelastic scattering of 64.8 MeV protons. PMID- 9953123 TI - Reactions 50Cr(p, gamma )51Mn and 50Cr(p,p' gamma )50Cr from 1.7 to 2.5 MeV. PMID- 9953122 TI - Particle emission associated with deep inelastic alpha -particle scattering at 35 MeV/nucleon. PMID- 9953124 TI - Resolution of the nature of the coupling in subthreshold fission in 238U+n. PMID- 9953125 TI - High-spin gamma -ray spectroscopy in 197Bi. PMID- 9953126 TI - Preequilibrium neutron emission in fusion of 165Ho+12C at 25 MeV per nucleon. PMID- 9953127 TI - Photon bremsstrahlung from ultrarelativistic nuclear collisions. PMID- 9953128 TI - Model for fusion and cool compound nucleus formation based on the fragmentation theory. PMID- 9953129 TI - Decay of excited projectile residues into complex fragments. PMID- 9953130 TI - Effects of entrance channel and compound nucleus in the fusion cross sections for 28Si PMID- 9953131 TI - Few-nucleon transfer in quasi-elastic collisions at 20 MeV/nucleon. PMID- 9953132 TI - Phenomenological consequences of a hypothetical light neutral particle in heavy ion collisions. PMID- 9953133 TI - Low energy pi + inelastic scattering from nuclei to the continuum. PMID- 9953134 TI - Theoretical antideuteron-nucleus absorptive cross sections. AB - Antideuteron-nucleus absorptive cross sections for intermediate to high energies are calculated using an ion-ion optical model. Good agreement with experiment (within 15 percent) is obtained in this same model for mean p-nucleus cross sections at laboratory energies up to 15 GeV. We describe a technique for estimating antinucleus-nucleus cross sections from N mean N data and suggest that further cosmic ray studies to search for antideuterons and other antinuclei be undertaken. PMID- 9953135 TI - Spin-rotation parameter Q for 800 MeV proton elastic scattering from 16O, 40Ca, and 208Pb. PMID- 9953137 TI - Problem of backward proton production. PMID- 9953138 TI - Estimate of the pionic contribution to very forward electron scattering from 3He by surprisal analysis. PMID- 9953136 TI - Medium energy probes and the interacting boson model of nuclei. PMID- 9953139 TI - Pion single charge exchange angular distributions at T pi =48 MeV. PMID- 9953140 TI - Relativistic treatment of p PMID- 9953141 TI - Photoactivation of isomeric levels in 113In and 87Sr. PMID- 9953142 TI - Shell-model calculation of 99Tc beta decay in astrophysical environments. PMID- 9953143 TI - R-matrix analysis of the beta +/--delayed alpha spectra from the decay of 8Li and 8B. PMID- 9953145 TI - Shape transition in Os and Pt isotopes. PMID- 9953144 TI - Thermostatic properties of nuclear matter at low temperature in a saturating chiral field theory. PMID- 9953146 TI - Interacting boson model with surface delta interaction between nucleons: Structure and interaction of bosons. PMID- 9953147 TI - Skyrme-force parametrization: Least-squares fit to nuclear ground-state properties. PMID- 9953148 TI - Elastic vibrational approach to giant resonances of deformed nuclei. PMID- 9953149 TI - Determination of the neutron and proton effective charges in the quadrupole operator of nuclear collective models. PMID- 9953150 TI - Coulomb excitation of 157Gd. PMID- 9953151 TI - Spin distribution of compound nucleus formed by near-barrier fusion. PMID- 9953152 TI - Nucleon-nucleon final state interactions in NN-->NN pi. PMID- 9953154 TI - Determination of an effective radius from the gamma-ray multiplicities in fusion reactions. PMID- 9953155 TI - Coherent damping of excitations in nuclear collisions from the energy-weighted inelastic sum rule. PMID- 9953153 TI - Theoretical estimates of photoproduction cross sections for neutral subthreshold pions in carbon-carbon collisions. AB - Using the Weizsacher-Williams method of virtual quanta, total cross section estimates for the photoproduction of neutral subthreshold pions in carbon-carbon collisions at incident energies below 300 MeV/nucleon are made. Comparisons with recent experimental data indicate that the photoproduction mechanism makes an insignificant contribution to these measured cross sections. PMID- 9953157 TI - Novel aspects of the carbon-decay mode of radium. PMID- 9953156 TI - Erratum: Fusion-energy reaction 2H(t,a)n from Et=12.5 to 117 keV PMID- 9953158 TI - Quadrupole moment of 107Agm determined by level mixing resonance on oriented nuclei. PMID- 9953159 TI - Level structure and electromagnetic properties in 212Ra. PMID- 9953160 TI - Quantum mechanical signature in exclusive coherent pion production. AB - We calculate the coherent production of pions from subthreshold to relativistic energies in heavy-ion collisions using a quantum, microscopic, many-body model. For the first time, in this approach, we use harmonic oscillator wave functions to describe shell-model information. The theoretical quantum mechanical results obtained for the pion spectra represent an important improvement over our previous microscopic, many-body calculations. PMID- 9953161 TI - Nucleon-deuteron doublet scattering lengths with three-nucleon potentials. PMID- 9953162 TI - 4He(p PMID- 9953164 TI - Charge-symmetry breaking in neutron-proton scattering: Isospin-mixing parameter. PMID- 9953163 TI - Triad of three-particle Lippmann-Schwinger equations. PMID- 9953165 TI - Optimal approximation to elastic and inelastic scattering on a bound nucleon system. PMID- 9953166 TI - Separable representation of the Bonn nucleon-nucleon potential. PMID- 9953167 TI - Optical model calculation of elastic and charge exchange scattering of protons from trinucleons. PMID- 9953168 TI - Separable approximation to the NN Paris potential in the framework of the Bethe Salpeter equation. PMID- 9953169 TI - Iteration-subtraction method for scattering equations compared with continued fractions method. PMID- 9953170 TI - Exit doorways and intermediate structure resonances. PMID- 9953171 TI - Neutron inelastic scattering from 54,56Fe. PMID- 9953172 TI - Formulation of elastic and inelastic breakup-fusion reactions. PMID- 9953173 TI - Search for superheavy elements in damped collisions between 238U and 248Cm. PMID- 9953175 TI - High-spin states of 97Rh. PMID- 9953174 TI - Selectivity in 13C(6Li,p)18O. PMID- 9953177 TI - Heavy systems at intermediate energies in the Boltzmann-Uehling-Uhlenbeck approach. PMID- 9953176 TI - Fusion-fission dynamics at high excitation energies studied by neutron emission. PMID- 9953178 TI - Nuclear interferometry and thermal freeze out. PMID- 9953180 TI - Fission fragment angular distributions. PMID- 9953179 TI - Cross sections for the production of 11C in C targets by 20Ne and 56Fe at relativistic energies. PMID- 9953181 TI - Fitting scenarios in a simple theoretical approach to 1s level shifts in pionic atoms. PMID- 9953183 TI - pi +d--> pi PMID- 9953182 TI - pi +d--> pi PMID- 9953184 TI - pi 0 eta and pi 0 eta ' mixing and the reaction d PMID- 9953185 TI - Hybrid quark-hadron model of Lambda nonmesonic decay: Finite nuclei. PMID- 9953187 TI - Calculation of the ( Delta -h, p-h) Landau parameter g Delta ' from a many-body Hamiltonian including pi and Delta degrees of freedom. PMID- 9953186 TI - Triple-differential cross sections of the ( pi +,pp) reaction on lithium isotopes. PMID- 9953188 TI - Relativistic plane-wave impulse approximation for nuclear inelastic scattering of protons and electrons. PMID- 9953190 TI - Model-independent error analysis of K+-nucleus elastic scattering. PMID- 9953189 TI - Pion-induced pion production on the deuteron. PMID- 9953191 TI - Nonmesonic nucleon decay in nuclei. PMID- 9953193 TI - Summed strength and signature properties of magnetic multipole excitations in a single j shell. PMID- 9953192 TI - Shape coexistence and level structure of 100Zr from decay of the low-spin isomer of 100Y. PMID- 9953194 TI - Microscopic calculations in the A=6 system. PMID- 9953195 TI - Clustered quark matter. PMID- 9953196 TI - Relativistic effects in three-body bound states. PMID- 9953197 TI - Model-space nuclear matter calculations with the Paris nucleon-nucleon potential. PMID- 9953198 TI - 3He(p PMID- 9953200 TI - Equivalent local Dirac potentials and nuclear magnetic moments. PMID- 9953199 TI - Major mechanism of photoactivation for the 115In( gamma, gamma ') 115Inm process by 60Co gamma -ray irradiation. PMID- 9953202 TI - Exclusion effect of a strong, short-range, attractive real potential. PMID- 9953201 TI - Comparison of K-p bound state calculations. PMID- 9953203 TI - Simultaneous electromagnetic enhancement of nuclear beta decay and internal conversion. PMID- 9953204 TI - Production of neutral pions in heavy-ion collisions at Elab PMID- 9953206 TI - Macroscopic limit of the microscopic SU(3) PMID- 9953205 TI - Spin-flip decomposition of the spectrum for 90Zr(p,n) at Ep PMID- 9953207 TI - Electroexcitation of isoscalar states in sup16O. PMID- 9953209 TI - Four-body calculation of the breakup reaction 3He(p,pd)1H. PMID- 9953208 TI - Role of the Delta (1232) in the ( gamma,p) reaction. PMID- 9953210 TI - Resonant E2 capture into the 8Be ground state. PMID- 9953211 TI - Multipole collectivity in 168Er from inelastic scattering. PMID- 9953212 TI - Convergence of distorted wave methods: Theory and a simple example. PMID- 9953213 TI - Two-component exciton model: Basic formalism away from shell closures. PMID- 9953215 TI - Isovector deformation parameters from coupled-channel analysis of (p,n) reactions. PMID- 9953214 TI - Inelastic scattering of 65-MeV polarized protons from 178Hf, 180Hf, 182W, and 184W and multipole moments of the optical potential. PMID- 9953216 TI - Test of the triaxial rotor model and the interacting boson fermion approximation model description of collective states in 191Ir. PMID- 9953217 TI - Intranuclear cascade models lack dynamic flow. PMID- 9953218 TI - Constrained-phase-space approach to spin alignment in deep-inelastic heavy-ion collisions. PMID- 9953219 TI - Fast and slow processes in the fragmentation of 238U by 85 MeV/nucleon 12C. PMID- 9953220 TI - Pion production in inelastic and central nuclear collisions at high energy. PMID- 9953221 TI - Quantal and semiclassical methods in relativistic electromagnetic excitation. PMID- 9953223 TI - Angular distributions and mechanisms for light fragment formation in relativistic heavy-ion collisions. PMID- 9953222 TI - 7Li+12C: Excitation of projectile and target states and single-nucleon stripping. PMID- 9953224 TI - Multinucleon transfer reactions with 7Li PMID- 9953225 TI - Pion production in heavy ion collisions near absolute thresholds. PMID- 9953226 TI - Triton and alpha emission in the thermal-neutron-induced ternary fission of 233U, 235U, 239Pu, and 241Pu. PMID- 9953228 TI - Fragment shell effect in low energy fission: Independent yields of technetium isotopes in the thermal-neutron-induced fission of 239Pu. PMID- 9953227 TI - Nuclear friction and lifetime of induced fission. PMID- 9953230 TI - Pion production cross sections and analyzing powers in the inclusive 12C(p, pi +)X reaction at 400 and 450 MeV. PMID- 9953229 TI - Pion optical potential with Delta dynamics. PMID- 9953233 TI - Sum rules for the longitudinal response in inclusive electron scattering. PMID- 9953232 TI - Pion absorption on nuclei at 65 MeV. PMID- 9953231 TI - Covariant time-ordered perturbation theory. PMID- 9953234 TI - Energy dependence of the 6Li(p, Delta ++)6He reaction. PMID- 9953235 TI - Electric monopole transitions in 102Ru. PMID- 9953236 TI - Magnetic moments of the 21+ states in 146,148Ce. PMID- 9953237 TI - Isomerism in 148Pr and the low-lying levels of 148Nd. PMID- 9953239 TI - Symmetric and antisymmetric states: A general feature of two-component systems. PMID- 9953240 TI - Quark cluster probabilities in nuclei. PMID- 9953238 TI - Adequacy of the boson basis and the identification of spurious states. PMID- 9953241 TI - Color-dielectric model as an explanation of the Nolen-Schiffer anomaly. PMID- 9953242 TI - Reanalysis of nuclear level widths from particle-x-ray coincidence experiments. PMID- 9953243 TI - Angular distributions for 14C,26Mg( pi +, pi -). PMID- 9953245 TI - Photon scattering by gamma -soft nuclei. PMID- 9953244 TI - Coexistence models for the 01+ and 02+ states in Ge isotopes. PMID- 9953246 TI - Amount of breathing mode admixture in the first excited state of 4He. PMID- 9953247 TI - Effective radii of light composites produced in relativistic heavy ion collisions. PMID- 9953248 TI - Spin structure of (1/2)+1-->(1/2)+0; the reaction p PMID- 9953249 TI - Comment on the A dependence of antiproton nuclear absorption cross sections. PMID- 9953251 TI - Relativistic nuclear model and 0(+) PMID- 9953250 TI - Comment on "Exact boson mappings for the nuclear neutron (proton) p shell with the symmetry SO(7) PMID- 9953252 TI - Reply to the Comment "Relativistic nuclear model and 0(+) PMID- 9953254 TI - Band structure change in Z>50 region: Doubly odd 120,122Cs and 126,128La. PMID- 9953253 TI - Erratum: Boltzmann equation for heavy ion collisions PMID- 9953255 TI - Global transverse momentum analysis for Ar+KCl and Ar+BaI2 at 1.2 GeV/nucleon. PMID- 9953257 TI - Multiple-scattering effects in electron-nucleus collisions. PMID- 9953256 TI - Isoscalar monopole and dipole strength between 10 and 20 MeV in 24Mg from inelastic alpha scattering at and around 0 degrees. PMID- 9953258 TI - Coupled-channel analysis of nucleon scattering from sup40Ca up to 80 MeV. PMID- 9953259 TI - Low-energy level structure of 151Sm by neutron capture reactions and theoretical interpretation. PMID- 9953260 TI - Direct calculation of the S matrix for scattering of charged particles. PMID- 9953262 TI - Deuteron-proton breakup reaction at Ed PMID- 9953261 TI - Test of time reversal invariance in p-p elastic scattering at 198.5 MeV. PMID- 9953264 TI - Alternative formulation of post-form distorted-wave Born approximation theory of nuclear breakup. PMID- 9953263 TI - Pseudostate calculations in n+t and p+3He systems. PMID- 9953265 TI - Measurement of the branching ratio 3H(d, gamma )/3H(d,n) using thick tritium gas targets. PMID- 9953267 TI - Cross sections for the Ti(p,n) reaction to analogs of ground and 2+ excited states. PMID- 9953266 TI - Optical potential approach in scattering of hadrons from light nuclei. PMID- 9953268 TI - Medium spin states in 83Kr. PMID- 9953270 TI - Elastic magnetic scattering on 51V. PMID- 9953269 TI - Siegert's theorem and nuclear electrodisintegration. PMID- 9953272 TI - Knockout and knockout-fusion contributions to the (p,p')-type singles cross sections. PMID- 9953271 TI - Microscopic calculation of neutrino capture rates in 69,71Ga and the detection of solar and galactic neutrinos. PMID- 9953273 TI - 12C+17O reaction. PMID- 9953274 TI - Experimental evidence and the Landau-Zener promotion in nucleus-nucleus collisions. PMID- 9953275 TI - Pion production as a test of nuclear matter properties. PMID- 9953276 TI - Direct and compound components of the 27Al(6Li, alpha )29Si reaction at 32 MeV. PMID- 9953278 TI - Two-particle correlation functions in the thermal model and nuclear interferometry descriptions. PMID- 9953277 TI - Liquid-gas phase separation in nuclear collisions. PMID- 9953279 TI - Experimental search for nonfusion yield in the heavy residues emitted in the 11B+12C reaction. PMID- 9953280 TI - Actinide production in reactions of heavy ions with 248Cm. PMID- 9953281 TI - Quasi-elastic processes in the 28Si+40Ca reaction at 225 MeV. PMID- 9953282 TI - Mechanism of the heavy-ion charge exchange reaction 12C(12C,12N)12B at 35 MeV/nucleon. PMID- 9953284 TI - Simplex splitting in the light actinides. PMID- 9953283 TI - Stopping of heavy nuclei in relativistic heavy-ion collisions. PMID- 9953286 TI - Coupled cluster description of pion-nucleon systems. PMID- 9953285 TI - Virtual photon theory in electrofission. PMID- 9953287 TI - Capture of medium-energy positrons in deuterium. PMID- 9953288 TI - Parity violation in deuteron electrodisintegration near threshold with a (0.5 4.0) GeV electron beam. PMID- 9953289 TI - 18O(p PMID- 9953290 TI - Pauli-principle effects in pion scattering from the lightest nuclei. PMID- 9953291 TI - Pion-nucleon charge exchange and scattering at low energies. PMID- 9953292 TI - Pion production: A probe for coherence in medium-energy heavy-ion collisions. PMID- 9953293 TI - 67Li( pi +,pd)3,4He reactions at 59.4 MeV. PMID- 9953294 TI - Coupled-channel effects in low-energy elastic pion scattering. PMID- 9953295 TI - Bag model with diffuse surface. PMID- 9953296 TI - Elastic pi + and pi - scattering on 14C at 164 MeV. PMID- 9953297 TI - Magnetic moments of the (3/2)1- and (5/2)1- states in 107,109Ag. PMID- 9953298 TI - Hole-hole and hole-particle representations of the dynamical symmetries of odd odd nuclei. PMID- 9953299 TI - Exchange effects in the interacting boson-fermion model. PMID- 9953300 TI - Test of the proton-neutron interacting boson-fermion model in the region around A=190. PMID- 9953301 TI - Particle-hole interacting boson approximation applied to 56Ni. PMID- 9953302 TI - Unbroken SU(3) symmetry and the relation of interacting-boson-model parameters with the shell model. PMID- 9953303 TI - 40Ca( gamma,p0)39K reaction for E gamma =100-300 MeV. PMID- 9953305 TI - Signs of the quadrupole moments of the 8(+) isomers in 88,90Zr. PMID- 9953304 TI - Incomplete mass transfer in 12C and 14N reactions on medium-heavy targets at 15 and 30 MeV/nucleon. PMID- 9953306 TI - Search for the E5(51--->02+) transition in 90Zr. PMID- 9953308 TI - Multipole moments for 12C from coupled channels analysis of 0.8 and 1.0 GeV proton scattering. PMID- 9953307 TI - g9/2 single particle state in 28Si. PMID- 9953310 TI - Importance of third- and higher-order virtual nuclear excitation contributions to the nucleon-nucleus interaction. PMID- 9953309 TI - Nucleon-nucleon force in a skyrmion model stabilized by omega exchange. PMID- 9953311 TI - Erratum: Backward cross section in the generalized exciton model PMID- 9953312 TI - Large angle correlations in 40 MeV/nucleon 12C PMID- 9953313 TI - Evidence for h11/2 neutron alignment in band crossings for the transitional mass 100 nuclei. PMID- 9953314 TI - Transfer cross sections from reactions with 254Es as a target. PMID- 9953315 TI - Nuclear effects in electroproduction. PMID- 9953316 TI - Quasimolecular resonances in terms of dipole and quadrupole interacting bosons. PMID- 9953318 TI - Configuration mixing in preequilibrium reactions: A new look at the hybrid exciton controversy. PMID- 9953317 TI - Validity of macroscopic models for the sup3He( alpha, gamma )7Be electric-dipole capture reaction. PMID- 9953319 TI - Determination of nonlocal potentials from the phase shifts. PMID- 9953321 TI - Collective aspects of 91Zr by (d,d') scattering at 17 MeV. PMID- 9953320 TI - Gamow separable approximations for realistic N-N interactions: Single channel case. PMID- 9953322 TI - Coulomb correction effect in Delbruck scattering and atomic Rayleigh scattering of 1-4 MeV photons. PMID- 9953323 TI - Semimicroscopic calculations of elastic, inelastic, and total neutron scattering by 239Pu in the energy range 10 keV <= En <= PMID- 9953324 TI - Elastic scattering of protons from 40,42,44,48Ca from 20 to 50 MeV and nuclear matter radii. PMID- 9953325 TI - Microscopic model for nuclear breakup in heavy ion collisions. PMID- 9953326 TI - Excited states in neutron-deficient 195Bi. PMID- 9953327 TI - Comparison of 6Li- and 7Li-induced fusion cross sections on 16O. PMID- 9953329 TI - Analytical study of nuclear mean field effects in high-energy nucleus-nucleus collisions. PMID- 9953328 TI - Electromagnetic dissociation of 59Co, 89Y, and 197Au targets by relativistic heavy ions to Z=26. PMID- 9953330 TI - Potential barriers and Landau-Zener promotion in the inelastic excitation of 17O by 13C ions. PMID- 9953332 TI - Fragmentation in the mechanical instability region. PMID- 9953331 TI - Sub-barrier fusion of the oxygen isotopes: A more complete picture. PMID- 9953334 TI - Preequilibrium analysis of exclusive neutron spectra following nuclear capture of stopped pions. PMID- 9953333 TI - Medium effects in photopion reactions. PMID- 9953335 TI - Pion absorption on 3He at T pi =62.5 and 82.8 MeV. PMID- 9953336 TI - Identification and decay of neutron-rich 102Sr and level structure of A~100 Y nuclei. PMID- 9953338 TI - Faddeev calculations of the 2 pi -3N force contribution to the 3H binding energy. PMID- 9953337 TI - Experimental mass excess of 49K and 50K. PMID- 9953339 TI - Delta isobars in finite nuclei and nuclear matter. PMID- 9953340 TI - Application of a number-conserving boson expansion theory to Ginocchio's SO(8) model. PMID- 9953341 TI - Three-body mesonic retardation effect. PMID- 9953342 TI - Boson-fermion hybrid representation of the antisymmetrizer and an effective Hamiltonian in hybrid space. PMID- 9953344 TI - Onset of helium-fragment scaling in heavy ion collisions. PMID- 9953343 TI - g factors of the lowest (5/2)+ and (7/2)+ states in 197Au and calibration of the transient magnetic field in Gd. PMID- 9953346 TI - Absolute 12C( gamma,p PMID- 9953345 TI - Influence of giant dipole resonance structure on elastic gamma-ray scattering from 209Bi. PMID- 9953347 TI - 0(-) state at low excitation energy in 26Al. PMID- 9953348 TI - Measurement of the pi d PMID- 9953349 TI - Angular correlation measurements in the 27Al(16O, alpha 12C) reaction at 65 MeV bombarding energy. PMID- 9953350 TI - Random-phase-approximation calculations and residual interactions in the sigma tau channel. PMID- 9953351 TI - Rapid calculation of exact spin distributions of multilevel configurations. PMID- 9953352 TI - Lorentz-Lorenz effect and the Kemmer-Duffin-Petiau equation. PMID- 9953353 TI - Monoenergetic positron conversion in heavy ion fragments. PMID- 9953354 TI - Nuclei far off stability in the NpN PMID- 9953355 TI - Asymmetry and angular distribution of deuteron photodisintegration in the 20-60 MeV range. PMID- 9953356 TI - Giant resonance coupling and l-dependent potentials for 16O. PMID- 9953357 TI - Phenomenological fit to deuteron photodisintegration data in the medium energy region. PMID- 9953359 TI - Parity violating asymmetries in the scattering of transversely polarized protons. PMID- 9953358 TI - Comparison of the standard Paris potential and its separable representation in the nuclear matter problem. PMID- 9953361 TI - Erratum: Collective M states in the classical limit of the neutron-proton interacting boson model PMID- 9953360 TI - Reply to "Parity violating asymmetries in the scattering of transversely polarized protons" PMID- 9953362 TI - Evidence for a coexisting four-particle, four-hole band in doubly closed subshell 96Zr. PMID- 9953363 TI - Measurement of pi +/ pi - cross section ratio for the giant quadrupole resonance in 208Pb. PMID- 9953364 TI - Breakup of Ne at 11 and 15 MeV/nucleon. PMID- 9953366 TI - Few channel models of nuclear reactions: Proton and deuteron elastic scattering expansions. PMID- 9953365 TI - Intermediate and weak coupling in 219Ra. PMID- 9953367 TI - Few channel models of nuclear reactions: Distorted-wave Born approximation for light-ion-induced transfer processes. PMID- 9953368 TI - Approximations for the treatment of final state interactions in nuclear knockout form factors. PMID- 9953369 TI - Deep inelastic separated response functions from 40Ca and 48Ca. PMID- 9953370 TI - Inelastic electron scattering from collective levels of 154Gd. PMID- 9953372 TI - Polarization transfer and the spin-parity composition of the charge-exchange continuum. PMID- 9953371 TI - Electroexcitation of giant multipole resonances in 63Cu. PMID- 9953373 TI - Nuclear structure effects in preequilibrium reactions: alpha -induced reactions on 24,25,26Mg, 27Al, and 28Si. PMID- 9953374 TI - Cross section and analyzing power measurements for the giant resonance region in 208Pb with 200-MeV protons. PMID- 9953375 TI - Statistical decay of giant resonances. PMID- 9953376 TI - Search for structure in the fusion of 28Si+28,30Si and 30Si+30Si. PMID- 9953377 TI - One-nucleon-transfer reactions induced by 352-MeV 18O on 28Si. PMID- 9953378 TI - Production of cold target-like fragments in the reaction of 48Ca+248Cm. PMID- 9953379 TI - Evolving collectivity at high spins in 157Er, 158Er, and 159Er. PMID- 9953381 TI - Double NN scattering effects in the ion-ion interaction at intermediate energies. PMID- 9953380 TI - Lambda 0 nonpolarization: Possible signature of quark matter. PMID- 9953383 TI - Fusion, transfer, and elastic scattering at sub-barrier energies for 16,18O ions on 208Pb and 15N and 16O ions on 209Bi. PMID- 9953382 TI - Search for superdeformation effects in 144Gd. PMID- 9953384 TI - Projection operator method for resonances in repulsive core potentials. PMID- 9953385 TI - Heavy ion peripheral collisions at relativistic energies: Theory of giant quadrupole excitation. PMID- 9953387 TI - Inelastic proton excitation of high-lying giant resonances. PMID- 9953386 TI - Macroscopic model of rotating nuclei. PMID- 9953388 TI - Relativistic effects on spin observables in quasielastic proton scattering. PMID- 9953390 TI - Relativistic one-pion-exchange potentials. PMID- 9953389 TI - Subthreshold K+ production on many-quark configurations in nuclei. PMID- 9953391 TI - Reaction p+12C-->13C+ micro++ nu micro and the weak form factors in the timelike region. PMID- 9953392 TI - Low equation, pion-nucleon scattering, and Castillejo-Dalitz-Dyson pole. PMID- 9953393 TI - Pion single charge exchange on 14C from 35 to 295 MeV. PMID- 9953395 TI - Solar neutrinos from the decay of 8B. PMID- 9953394 TI - Relativistic three-body approach to NN scattering at intermediate energies. PMID- 9953398 TI - Decay of 7.3-min 235Th and 24.6-min 235Pa. PMID- 9953397 TI - 234U excited states fed in the beta decay of 234Pa. PMID- 9953396 TI - Distortion in the beta -decay spectrum for low electron kinetic energies. PMID- 9953399 TI - Characterization of isomers in 158Ho. PMID- 9953400 TI - Half-life limit for 48Ca(2 beta -)48Ti(02+,2997). PMID- 9953402 TI - K-shell ionization in the beta decay of 141Ce. PMID- 9953401 TI - Mechanism of pion double charge exchange at T pi =292 MeV. PMID- 9953403 TI - Magnetic moment and lifetime of the 127 keV state in 101Ru. PMID- 9953405 TI - Nuclear reactions of silver with 0.8-TeV protons. PMID- 9953404 TI - Spin-dipole isovector resonances in 12C and 6Li by positive photopion production. PMID- 9953406 TI - Valence proton orbit radii and total rms charge radii in the tin region. PMID- 9953407 TI - Effect of variation of the single particle energies in the structure of N=82 isotones. PMID- 9953409 TI - Nuclear wave function considerations in pion photoproduction. PMID- 9953408 TI - Collective flow in Ar+KCl at 1.8 GeV/nucleon. PMID- 9953410 TI - 26Al(n,p)26Mg reaction: Comparison between the Hauser-Feshbach formula and the exact random-matrix result for the cross section. PMID- 9953412 TI - 4H and (n, alpha x) reactions on 6Li and 7Li. PMID- 9953411 TI - Rotational band structure in 133Pr. PMID- 9953413 TI - Thermalization in ultrarelativistic heavy ion collisions: Parton cascade approach. PMID- 9953414 TI - Application of a hot spot model to fragment emission from pion true absorption. PMID- 9953416 TI - Three remarks on the 3s proton. PMID- 9953415 TI - Temperature-induced deformation in 148Sm. PMID- 9953417 TI - U PMID- 9953418 TI - Calculation of the one-photon decay rate of the polyelectron P++- PMID- 9953419 TI - Alternative interpretations of the many-particle Lippmann-Schwinger equation. PMID- 9953420 TI - Higher order perturbation treatment of three-nucleon forces in the Faddeev equations. PMID- 9953421 TI - Microscopic theory of the 4He system with multichannel resonating-group method. PMID- 9953423 TI - Anomalous absorption of proton partial waves by the optical potential. PMID- 9953422 TI - 4He D-state effects in the 2H(d, gamma )4He reaction at low energies. PMID- 9953424 TI - Giant resonance structure in 208Pb measured using the (p,p') reaction at 334 MeV. PMID- 9953425 TI - Interaction of 5-50 MeV/nucleon 3He and 4He with 59Co. PMID- 9953427 TI - Complex scaling in the description of nuclear resonances. PMID- 9953426 TI - Particle-hole strength excited in the 40Ca(p,n)40Sc reaction at 134 MeV. PMID- 9953428 TI - Pairing effects and multistep direct and compound emission in the 92-100Mo(p,xn) reactions. PMID- 9953429 TI - Calculation of mass yields for proton-nucleus spallation reactions. PMID- 9953430 TI - Global analysis of the intranuclear cascade model. PMID- 9953431 TI - High-spin (f7/2)A-40 states in 47Ti, 47Sc, 44Ca, 45Ca, and 48Ti via 36S+14C fusion-evaporation reactions. PMID- 9953432 TI - Resonances in the low-energy 13C+13C spectrum. PMID- 9953434 TI - Light fragment production in the interaction of 84 MeV/nucleon 12C with 208Pb. PMID- 9953433 TI - Incomplete fusion in the 40Ar+68Zn reaction: Trends and limits. PMID- 9953435 TI - Disassembly of hot classical charged drops. PMID- 9953436 TI - Influence of shape fluctuations in relativistic heavy ion collisions. PMID- 9953437 TI - Pion interferometry predictions for relativistic heavy-ion collisions using the intranuclear cascade model. PMID- 9953439 TI - Effect of nuclear dissipation on neutron emission prior to fission. PMID- 9953438 TI - Fusion cross section of the 16O+13C reaction. PMID- 9953440 TI - Fission fragment properties in fast-neutron-induced fission of 237Np. PMID- 9953441 TI - Delta N interaction and pi d observables. PMID- 9953443 TI - Effect of pi pi interactions in pi N scattering. PMID- 9953442 TI - Elastic scattering of polarized protons from 3He at intermediate energies. PMID- 9953445 TI - Energy dependence of the low energy pion-nucleus optical potential. PMID- 9953444 TI - Relativistic dynamics of spin-one particles and deuteron-nucleus scattering. PMID- 9953447 TI - Operator PMID- 9953446 TI - Effects of nuclear correlations on low-energy pion charge-exchange scattering. PMID- 9953448 TI - Geometry and time scales of self-consistent orbits in a modified SU(2) model. PMID- 9953449 TI - Test of forbidden state NN potential in the 3N system. PMID- 9953450 TI - Collective systematics in the mass 80 region. PMID- 9953451 TI - Giant quadrupole resonance in rotating light nuclei in the calcium region. PMID- 9953453 TI - Intermediate and compound structure in the 16O+16O system. PMID- 9953452 TI - Direct contributions to the decay of isoscalar giant resonances in 58Ni. PMID- 9953454 TI - Strong anomaly in the d-p bremsstrahlung. PMID- 9953455 TI - Nuclear macroscopic properties and pionic exchange currents in (e,e' PMID- 9953456 TI - Effect of final-state interactions in tritium beta decay. PMID- 9953457 TI - Hole-transition rates in a Fermi gas model. PMID- 9953458 TI - Anomaly in spectra of 105Pd and 103Ru. PMID- 9953459 TI - Screening of the tensor force in the isoscalar M1 state in 208Pb. PMID- 9953460 TI - Spin-flip probability in the 12C(13C,13C')12C*(2(+)) reaction. PMID- 9953461 TI - F-spin multiplets and alpha transfer systematics in the interacting boson model. PMID- 9953462 TI - Importance of quadrupole coupling for low energy pion charge exchange reactions. PMID- 9953463 TI - Nucleus-nucleus potential from fusion and elastic scattering. PMID- 9953465 TI - Systematics of spontaneous emission of intermediate mass fragments from heavy nuclei. PMID- 9953464 TI - Comment on "Method for observation of neutrinos and antineutrinos" PMID- 9953466 TI - Excitation of isovector giant resonances in 27Al by heavy ion charge exchange reaction. PMID- 9953467 TI - Surface and elastic effects in isovector giant resonances. PMID- 9953468 TI - sup18O(p PMID- 9953470 TI - Analyzing power of 27Al(n PMID- 9953469 TI - Energy variation of the matrix element in the statistical breakup of light nuclei below the pion production threshold. PMID- 9953471 TI - Radiative neutron capture by deuterium. PMID- 9953472 TI - Spin dependence of the isospin-forbidden decay 8Be(Ex=27.5 MeV)-->d PMID- 9953473 TI - Direct E2 neutron capture in light nuclei. PMID- 9953474 TI - Differential cross section for the 2H( gamma,p)n reaction between 100 and 255 MeV. PMID- 9953475 TI - Analyzing-power measurements in the 48Ca(p,n)48Sc reaction at 134 MeV. PMID- 9953476 TI - 208Pb PMID- 9953477 TI - Levels in 99Ru populated by the (3He,2n gamma ) reaction: Complete particle-core multiplets. PMID- 9953478 TI - 55Mn( PMID- 9953481 TI - Excitation function of 93Nb( PMID- 9953479 TI - Dependence upon mass number and neutron excess of the real part of the proton optical potential for mass numbers 44 <= A <= 72. PMID- 9953480 TI - Photon scattering from 206Pb. PMID- 9953482 TI - Quadrupole and hexadecapole moments of 232Th and 238U from inelastic scattering of 65 MeV polarized protons. PMID- 9953483 TI - Evaporation recoil effects: Asymmetries in neutron, projectile-fragment coincidences for 35 MeV/nucleon 14N PMID- 9953484 TI - Element distributions after binary fission of 44Ti. PMID- 9953485 TI - Spectroscopic study of the high-spin states in 135Pr. PMID- 9953487 TI - Entrance channel limit on the fusion of 28Si with 12C at high energy. PMID- 9953486 TI - Coincidence measurements of intermediate mass fragments produced in 32S-induced reactions on Ag at E/A=22.5 MeV. PMID- 9953488 TI - Reaction dynamics studied via positron and electron spectroscopy. PMID- 9953490 TI - Polarization of 12B produced in 14N-induced reactions. PMID- 9953489 TI - Yrast bands in 136,138Sm and 132Nd. PMID- 9953491 TI - Fragment angular distributions for neutron fission of 232Th. PMID- 9953493 TI - Elastic collisions between light nuclei and the phase variation of the nucleon nucleon scattering amplitude. PMID- 9953492 TI - (p, pi -) continuum spectra at intermediate energy in the local Fermi gas model. PMID- 9953494 TI - Forward-angle cross sections for pion-nucleon charge exchange between 100 and 150 MeV/c. PMID- 9953496 TI - Radiative pion capture on 13C. PMID- 9953495 TI - Continuum polarization transfer in 500 MeV proton scattering and pionic collectivity in nuclei. PMID- 9953497 TI - Elastic scattering of 65 MeV positive and negative pions from nickel isotopes. PMID- 9953498 TI - y scaling and final state interactions in 3He PMID- 9953499 TI - Decay of 83-min 139Ba to levels of 139La and the decay of 18-min 141Ba to levels of 141La. PMID- 9953501 TI - Ground state energy of a hard-sphere Fermi fluid. PMID- 9953500 TI - Search for the double- beta decay of 76Ge. PMID- 9953502 TI - Simplified boson mappings of symplectic shell model algebras. PMID- 9953503 TI - Semiclassical analysis of the interacting boson model for dipole resonances. PMID- 9953505 TI - Electromagnetic form factors of 3He and 3H and current conservation. PMID- 9953504 TI - Intrinsic states for the SU(3) limit of the interacting boson model. PMID- 9953506 TI - Yields of fission products produced by thermal-neutron fission of 243Cm. PMID- 9953507 TI - Fragments of charges 3 <= Z <= 14 from 84Kr and 40Ar at relativistic energies. PMID- 9953509 TI - Quadrupole moment of the first excited state of 136Ba. PMID- 9953508 TI - Mass of 146Gd. PMID- 9953511 TI - Dynamical model of nuclear fission with shell effects. PMID- 9953510 TI - 36,38Ar(d-bar, alpha )34,36Cl reactions induced by tensor polarized deuterons. PMID- 9953512 TI - Mechanism for double-charge exchange in heavy ion reactions. PMID- 9953513 TI - Resolution of the magnetic moment problem in relativistic theories. PMID- 9953514 TI - Hermitian treatment of Dyson boson theory. PMID- 9953516 TI - Erratum: Charge-symmetry breaking in neutron-proton scattering: Isospin-mixing parameter PMID- 9953515 TI - Statistical significance of forward-backward asymmetry of the fluctuating nuclear angular distributions. PMID- 9953517 TI - Expanding pion emitting source in Ar on Pb collisions. PMID- 9953519 TI - Behavior of projectile fragments of 1.88 GeV/nucleon 56Fe. PMID- 9953518 TI - Thermal population of nuclear excited states. PMID- 9953520 TI - Microscopic theory of the sup3H+ alpha system with the multichannel resonating group method. PMID- 9953521 TI - Potential model calculation of proton-proton bremsstrahlung using the Paris potential. PMID- 9953522 TI - Structure of 96Ru. PMID- 9953523 TI - Neutron total cross section of 40Ca and cross section difference of 44Ca-40Ca. PMID- 9953524 TI - Analyzing powers for 207Pb(t PMID- 9953525 TI - Differential cross sections and analyzing powers for neutron elastic scattering from 89Y between 8 and 17 MeV. PMID- 9953526 TI - Parities of bound dipole states in 40Ar. PMID- 9953527 TI - Spherical optical model potential for the Re/Os stellar nucleosynthesis chronometer from s-wave neutrons on 186,187,188Os. PMID- 9953528 TI - Effect of 8Be decay on nuclear temperature measurements. PMID- 9953530 TI - pn to d and alpha pn to alpha d emission ratios in heavy-ion-induced reactions. PMID- 9953531 TI - Clues to the shapes of very hot nuclei: Calculated patterns for evaporative emission from deformed nuclei. PMID- 9953529 TI - Light particle emission in 16O-induced reactions on 12C, 27Al, and 197Au at E/A=25 MeV. PMID- 9953532 TI - Anomalous behavior of singly charged relativistic secondary particles produced in collisions of 16O ions with emulsion nuclei at ~2A GeV. PMID- 9953533 TI - Geometric interpretation of the adiabatic model for heavy-ion fusion. PMID- 9953534 TI - Deexcitation of the complete fusion nucleus 155Tb. PMID- 9953536 TI - Rayleigh's criterion for the neck stability in heavy-ion reactions and fission. PMID- 9953535 TI - Actinides produced by 12C + 242Pu and 16O + 238U reactions. PMID- 9953537 TI - Particle-bound excited state yields produced in the reaction of 181 MeV 19F +159Tb. PMID- 9953538 TI - Phase transitions in quark-gluon matter. PMID- 9953540 TI - Model dependence of unitary isobar model treatments of NN-->NN pi at intermediate energies. PMID- 9953539 TI - Photoexcitation mechanisms and fission of 209Bi from threshold to the Delta region. PMID- 9953541 TI - Calculation of (K-, pi ) hypernuclear yields for stopped kaons in 12C. PMID- 9953543 TI - Renormalized pi NN coupling constant and the P-wave phase shifts in the cloudy bag model. PMID- 9953542 TI - Random phase approximation spin-isospin nuclear response in the deep inelastic region. PMID- 9953544 TI - Delta isobar Landau-Migdal parameters and the high momentum properties of the spin-isospin response functions. PMID- 9953546 TI - Internal conversion in an intense radiation field. PMID- 9953545 TI - Decay of 145Cs to levels of 145Ba. PMID- 9953547 TI - Probe of the shell crossing at A=40 via beta decay: Experiment and theory. PMID- 9953549 TI - Pionic retardation effects in two-pion-exchange three-nucleon forces. PMID- 9953548 TI - Charge radii and moments of tin nuclei by laser spectroscopy. PMID- 9953551 TI - High-spin yrast levels in doubly even germanium and selenium isotopes: Microscopic study in the variation-after-projection approach. PMID- 9953550 TI - Soliton matter as a model of dense nuclear matter. PMID- 9953552 TI - Hot rotating toroidal nuclei. PMID- 9953553 TI - Microscopic description of four-body excitations in heavy nuclei. PMID- 9953554 TI - (p,t) reaction on even-mass cadmium nuclei: Test for the admixture of intruder configurations in the ground states. PMID- 9953555 TI - Photon interactions below 9 MeV in Ba and Ce. PMID- 9953556 TI - Half-life measurements for neutron-rich Ag and Cd nuclei. PMID- 9953557 TI - Measurement of the optical isotope shift of 82Sr. PMID- 9953558 TI - Angular distributions of pi + in the 10B( gamma, pi +) reaction leading to low lying states of 10Be. PMID- 9953559 TI - Electromagnetic and hadronic form factors and operators in the interacting boson model. PMID- 9953560 TI - Implications of low lying M1 strengths for interacting boson approximation calculations. PMID- 9953561 TI - Stability of the ground state of finite nuclei against neutral pion condensation. PMID- 9953562 TI - Isovector M1 collective excitations in light nuclei. PMID- 9953563 TI - Comment on "Triad of three-particle Lippmann-Schwinger equations" PMID- 9953564 TI - Comment on "Triad of three-particle Lippmann-Schwinger equations" PMID- 9953566 TI - Doubly decoupled structures in 182,184Ir. PMID- 9953565 TI - Erratum: Few channel models of nuclear reactions: Proton and deuteron elastic scattering expansions PMID- 9953567 TI - Identification of the first excited state in the N=Z nucleus 3264Ge32. PMID- 9953569 TI - Density matrix expansion for microscopic optical model potential. PMID- 9953568 TI - M4 excitations in 13C. PMID- 9953570 TI - Charge dependence of the nucleon-nucleon interaction due to pion-mass difference. PMID- 9953571 TI - Convergence of a separable expansion method in three-nucleon calculations. PMID- 9953572 TI - Analyzing powers for (p PMID- 9953573 TI - Momentum space Faddeev calculation for N-d scattering below the breakup threshold. PMID- 9953574 TI - Electroexcitation of M4 transitions in 17O and 18O. PMID- 9953575 TI - Proton scattering and the interacting boson model in the s-d shell. PMID- 9953576 TI - Polarization effects in sub-Coulomb breakup of deuterons. PMID- 9953578 TI - Quasi-elastic electron scattering from 238U. PMID- 9953577 TI - Spin-parity measurements in 44,46Sc. PMID- 9953579 TI - Molecular interpretation of the oscillations of the fusion excitation function for the alpha +40Ca system. PMID- 9953581 TI - Low-lying levels in 45Sc. PMID- 9953580 TI - Damping of high-spin single-particle strengths in 209Pb. PMID- 9953582 TI - Identification of collective flow by transverse-momentum analysis of emulsion data for Au+AgBr and Xe+AgBr. PMID- 9953583 TI - Phase-integral calculation of phase shifts for a heavy-ion optical potential. PMID- 9953584 TI - Real part of the interaction potential between two 238U nuclei. PMID- 9953585 TI - Deexcitation of nuclei formed near the instability temperature. PMID- 9953586 TI - Impact parameter dependence of the specific entropy and the light particle yield in relativistic heavy ion collision. PMID- 9953587 TI - Transfer reactions for 28Si PMID- 9953588 TI - Dissolution of nucleons in giant nuclei. PMID- 9953589 TI - Analytical treatment of high-energy nucleus-nucleus collisions including mean field effects: Boltzmann equation approach. PMID- 9953590 TI - Angular correlations between projectile and target fragments emitted from nuclear collisions of 238U at 0.85A GeV. PMID- 9953591 TI - Angular distributions of low-energy neutrons from 390-MeV/nucleon Ne+Pb collisions. PMID- 9953592 TI - Form factors for a proximity interaction between deformed nuclei. PMID- 9953593 TI - Fission probes of sub-barrier fusion cross section enhancements and spin distribution broadening. PMID- 9953594 TI - Doorway states and cross-section fluctuations in the 12C PMID- 9953595 TI - Coincident electrofission of 238U at q PMID- 9953596 TI - Z and A identification of 370- micros 258Fm. PMID- 9953597 TI - Photofission cross section of 232Th. PMID- 9953598 TI - Observation of the 12C( 3He, pi +)15N reaction near threshold using recoil detection. PMID- 9953599 TI - Use of polarization in pion-nucleon bremsstrahlung. PMID- 9953600 TI - Quasielastic proton-nucleus scattering at 300-800 MeV. PMID- 9953601 TI - Applications of the pi NN bound-state problem: The deuteron and the 4,4 resonance. PMID- 9953603 TI - Relativistic approach to photon-nucleon scattering. PMID- 9953602 TI - Determination of proton-nucleon analyzing powers and spin-rotation-depolarization parameters at 500 MeV. PMID- 9953604 TI - Nuclear deexcitation via an inelastic electronic bridge. PMID- 9953605 TI - Interpretation of states in 105Ag utilizing a particle-rotor model. PMID- 9953606 TI - Thermal response of states of approximate angular momentum in the finite temperature restricted Hartree-Fock approximation. PMID- 9953607 TI - Trinucleon charge densities and three-nucleon forces. PMID- 9953608 TI - M1 transitions between low-lying levels in 128Xe and the proton-neutron interacting boson model. PMID- 9953609 TI - Branching ratio of the second excited state of 30P. PMID- 9953610 TI - 1+ state in 44Ca. PMID- 9953611 TI - Elastic and inelastic 16O+12C scattering at 38 MeV/nucleon. PMID- 9953612 TI - Dirac approach to anomalous magnetic moment calculations. PMID- 9953613 TI - Main parameters of charge-exchange resonance relaxation within the model of interacting and independently damping quasiparticles. PMID- 9953615 TI - Erratum: Fusion, transfer, and elastic scattering at sub-barrier energies for 16,18O ions on 208Pb and 15N and 16O ions on 209Bi PMID- 9953614 TI - Comparison of abrasion model differences in heavy ion fragmentation: optical versus geometric models. AB - Using an abrasion-ablation collision model, which includes contributions from frictional-spectator interactions and electromagnetic dissociation, analyses of the sensitivities of predicted fragmentation cross sections to the choice of a particular abrasion formalism are made using both geometric and optical potential abrasion models. Most cross section differences obtained using the two abrasion models are less than the present experimental uncertainties, suggesting that either abrasion model is suitable for estimating isotopic and elemental fragment distributions. PMID- 9953616 TI - Erratum: Further consequences of the excluded bound state S1/2 alpha -N interaction in 6He and 6Li PMID- 9953617 TI - 2H(d, gamma )4He reaction and the 4He D state. PMID- 9953618 TI - M3 transition in the two-rotor model. PMID- 9953620 TI - Two-body bound state problem and nonsingular scattering equations. PMID- 9953619 TI - Few-channel models of nuclear reactions: Three-body model for deuteron elastic scattering and breakup. PMID- 9953622 TI - pi -exchange NN interaction model with overlapping nucleon form factors. PMID- 9953621 TI - Stretched states in 26Mg from the 25Mg( alpha,3He) reaction at 81 MeV. PMID- 9953623 TI - Parity nonconservation in elastic p alpha scattering. PMID- 9953625 TI - On-shell equivalent transformations for eliminating energy dependence from coupled channel equations with nonlocal linearly energy-dependent potentials. PMID- 9953624 TI - Nucleon-nucleon and nucleon- Delta -isobar forces in a Skyrme model with higher derivative terms. PMID- 9953626 TI - Double-differential inclusive hydrogen and helium spectra from neutron-induced reactions at 27.4, 39.7, and 60.7 MeV: Oxygen and nitrogen. PMID- 9953627 TI - Self-energies of nuclei and real and imaginary optical model potentials. PMID- 9953628 TI - 80Se from the 78Se(t,p) reaction. PMID- 9953629 TI - Search for the Fermi-surface anomaly in fast-neutron scattering from yttrium. PMID- 9953630 TI - Tests of the factorized distorted wave impulse approximation for (p,2p) reactions. PMID- 9953631 TI - d5/2 isobaric analog state in 57Co from 56Fe(p, gamma ) and 56Fe(p,p' gamma ) reactions. PMID- 9953632 TI - Excited states of 97Ru and 103Ru. PMID- 9953634 TI - 3He cluster structure of 12C. PMID- 9953633 TI - Gold multifragmentation: Analysis of an exclusive experiment. PMID- 9953635 TI - Multistep fragmentation of heavy ions in peripheral collisions at relativistic energies. PMID- 9953636 TI - Mass of 57Cu. PMID- 9953637 TI - Three-pion correlations in relativistic heavy ion collisions. PMID- 9953638 TI - Formation and decay of the composite system in 40Ar-induced reactions at 15 MeV/nucleon. PMID- 9953639 TI - Neutron-fragment coincidence measurements in 14N+Ho and 14N+Ni reactions at 35 MeV/nucleon. PMID- 9953640 TI - Coulomb excitation study of 235U: Assessment of theoretical quasiparticle states. PMID- 9953641 TI - Fission-like yields in 16O+40,44Ca reactions. PMID- 9953642 TI - ( pi +/-,2N) reactions at 165 and 245 MeV. PMID- 9953644 TI - Isospin nonconservation in nucleon-nucleon scattering by a color force. PMID- 9953643 TI - pi p elastic scattering from 67 to 139 MeV. PMID- 9953645 TI - Importance of quark interchange in pion production via nucleon-nucleon scattering. PMID- 9953646 TI - Baryon exchange model for p PMID- 9953647 TI - 200-MeV- pi +-induced single-nucleon removal from 24Mg. PMID- 9953648 TI - Measurements on isovector giant resonances in pion charge exchange. PMID- 9953650 TI - Dirac equation with a separable potential. PMID- 9953649 TI - Signature for the existence of eta-mesic nucleus. PMID- 9953651 TI - Relativistic scattering operators for Dirac particles: Structure, symmetries, and reconstruction. PMID- 9953653 TI - Unitary meson-exchange calculation of NN-->NN pi reaction. PMID- 9953652 TI - Nuclear-structure aspects of nonanalog pion double charge exchange. PMID- 9953654 TI - Systematics of fragment angular distributions in high-energy proton reactions. PMID- 9953655 TI - Bose-Fermi symmetry chain for the description of odd-odd nuclei. PMID- 9953656 TI - "Exact" relativistic theory of two-body bound-state wave functions. PMID- 9953657 TI - Calculation of M1 transition rates at high spin in axial nuclei. PMID- 9953658 TI - Finite-temperature Hartree-Fock-Bogoliubov calculations in rare earth nuclei. PMID- 9953660 TI - New supersymmetry classification of nuclear levels in 195Pt. PMID- 9953659 TI - Dynamics of droplet formation in nuclear matter. PMID- 9953661 TI - Mass dependence of effective charges in the interacting-boson model. PMID- 9953662 TI - Physical interpretation and quantization of periodic time-dependent Hartree-Fock solutions. PMID- 9953663 TI - Four-body correlations in heavy nuclei. PMID- 9953664 TI - Measurement of magnetic dipole moments of 129Xem and 131Xem by spin exchange with optically pumped Rb. PMID- 9953665 TI - Search for 34Si ions in 241Am decay. PMID- 9953667 TI - Evidence for a 17 keV level in 168Tm. PMID- 9953666 TI - g factor of the 21+ state in 142Ba. PMID- 9953669 TI - Width of the second T=(3/2) state in 9Be. PMID- 9953668 TI - Phase shift analysis of 12C ion elastic scattering measured at very high energy. PMID- 9953670 TI - Lifetime measurement of excited states in 105Ag. PMID- 9953672 TI - Interacting boson model calculation of octupole states in deformed nuclei. PMID- 9953671 TI - Strong factor in the SO(2,3) S matrix. PMID- 9953673 TI - Hadronic excitation of the second 0+ state in 90Zr. PMID- 9953674 TI - Pauli distortion effect on the first-order optical potential. PMID- 9953676 TI - Giant M1 resonance in 140Ce. PMID- 9953675 TI - Erratum: Relativistic effects on spin observables in quasielastic proton scattering PMID- 9953677 TI - Relaxation of the mass-asymmetry degree of freedom in heavy-ion reactions. PMID- 9953678 TI - Surface effects and the spin-isospin nuclear response function. PMID- 9953679 TI - Gauge-invariant nuclear Compton amplitude manifesting low-energy theorems. PMID- 9953680 TI - Tensor-force effects in the 2H(d PMID- 9953681 TI - 36S(t,p gamma )38S reaction. PMID- 9953682 TI - E1-E2 interference in 159Tb( gamma,n) and 209Bi( gamma,n) reactions. PMID- 9953683 TI - 90,91Zr (n, alpha ) 87,88Sr reactions at 14.3 and 18.15 MeV incident neutron energy. PMID- 9953685 TI - Real part of the neutron and proton optical potentials at 11 MeV for mass numbers 40 <= A <= 76. PMID- 9953684 TI - Measurements and calculations of neutron scattering in the actinide region. PMID- 9953686 TI - Radial shape of the optical potential for 35 and 11 MeV protons on targets with mass number 10 pi pi N models used in A( pi,2 pi ) calculations" PMID- 9953724 TI - Reply to "Comment on 'Comparison of approximate chiral-dynamical pi N--> pi pi PMID- 9953725 TI - Erratum: Relativistic and nonrelativistic impulse approximation descriptions of 300-1000 MeV proton + nucleus elastic scattering PMID- 9953728 TI - Octupole deformation at high spin in the Ba-Sm region. PMID- 9953727 TI - Angular momenta of intermediate width structures in 12C PMID- 9953726 TI - Transverse quasielastic electron scattering from the deuteron. PMID- 9953729 TI - Analyzing power measurements of (d,2He) reactions on light nuclei. PMID- 9953731 TI - Boson mapping of the shell model algebra obtained from a seniority-dictated similarity transformation. PMID- 9953730 TI - Examination of the vector analyzing powers in the reaction 12C, 16O (d PMID- 9953733 TI - Phenomenological wave functions for the ground and 2.313 MeV states in sup14N. PMID- 9953732 TI - Delta excitations and shell-model information in heavy-ion, charge-exchange reactions. AB - We calculate total cross sections for coherent pion production using localized plane-wave approximations for the shell-structure of valence nucleons that are excited to delta particles in the intermediate state in the (12C, 12B) and (12C, 12N) charge-exchange, heavy-ion reactions. We find comparable agreement to projectile downshift data for 12C(12C, 12B)12N. Then we improve the formalism by replacing the localized plane wave bound states with harmonic oscillator states which are imbedded in a multipole expansion approach and calculate pion differential cross sections to test for the sensitivity of the spectra to the single-particle mass parameter. PMID- 9953734 TI - Nucleon-nucleon potential with quark degrees of freedom. PMID- 9953735 TI - Analysis of slow neutron capture by 9Be, 12C, and 13C. PMID- 9953736 TI - Proton radiative capture by deuterium between 100 and 200 MeV. PMID- 9953737 TI - 26Mg(p,n)26Al and 23Na( alpha,n)26Al reactions. PMID- 9953738 TI - On- and off-shell convergence of the time-independent mean-field theory of collisions. PMID- 9953739 TI - 2jth rank tensor polarization in reactions involving a spin j particle. PMID- 9953740 TI - Backward production of protons in proton-nucleus collisions at low and intermediate energy. PMID- 9953741 TI - Production of 91Nb, 94Nb, and 95Nb from Mo by 14.5-14.8 MeV neutrons. PMID- 9953742 TI - Nuclear structure of 231Th from neutron capture and (d,p) reaction measurements. PMID- 9953743 TI - Excitation of the high energy nuclear continuum in 208Pb by 22 MeV/nucleon 17O and 32S. PMID- 9953744 TI - Inclusive observables calculated with the nuclear random walk model: Application to the 40Ar+68Zn reaction at 14.6 and 27.6 MeV/nucleon. PMID- 9953745 TI - Target and projectile excitation of 7Li PMID- 9953746 TI - Correlations between alpha particles and evaporation residues for the 14N+12C reaction at E(14N)=180 MeV. PMID- 9953747 TI - Heavy ion collisions and anisotropic hydrodynamics. PMID- 9953748 TI - Linear momentum and angular momentum transfer in the reactions of 16O with 154Sm. PMID- 9953749 TI - Complete and incomplete fusion in 20Ne+93Nb reactions. PMID- 9953750 TI - Solving coupled equations by iteration for heavy-ion multiple Coulomb-nuclear excitation. PMID- 9953751 TI - Production and decay of highly excited nuclear systems formed in 84Kr +12C and 27Al collisions at 35 MeV/nucleon. PMID- 9953752 TI - Dependence of actinide production on the mass number of the projectile: Xe +248Cm. PMID- 9953753 TI - Radioactivity in strange quark matter. PMID- 9953755 TI - Unified description of pi d- pi d, pi d-NN, and NN-NN reactions at intermediate energies. PMID- 9953754 TI - Covariant light front perturbation theory and three-particle equations. PMID- 9953756 TI - Photonuclear spallation reactions in Cu. PMID- 9953757 TI - Muon and neutrino production in inclusive proton-12C reactions. PMID- 9953758 TI - Formal framework for the electroproduction of polarized nucleons from nuclei. PMID- 9953759 TI - Symmetric, Lorentz invariant NN amplitude: Yukawa representation. PMID- 9953760 TI - Relativistic random-phase-approximation response function for quasielastic electron scattering in local density approximation. PMID- 9953761 TI - Theory of kaonic hydrogen. PMID- 9953763 TI - Beta-delayed proton decay of 61Ge. PMID- 9953762 TI - Investigation of A=152 radioactivities with mass-separated sources: Identification of 152Lu. PMID- 9953764 TI - U(12) systematics in nuclei. PMID- 9953765 TI - Test of microscopic three-boson force in a six-fermion system. PMID- 9953766 TI - Shell-model evidence for the exchange term in the interacting-boson-fermion Hamiltonian. PMID- 9953767 TI - 16O( alpha, alpha p) and 40Ca( alpha, alpha p) reactions at 139.2 MeV incident energy. PMID- 9953768 TI - Excitation of 12C+ 12C "quasimolecular" resonances by inelastic scattering of 190 MeV protons from 24Mg. PMID- 9953770 TI - Nuclear level excitation during charge nonconservation. PMID- 9953769 TI - Observation of selective gamma decay of fission-like fragments in the 32S+58Ni reaction at 143 MeV. PMID- 9953771 TI - Cross section and transverse polarization transfer for the 2H(p,n)2p reaction at 160 MeV. PMID- 9953772 TI - Search for superdeformed shapes in 144Gd. PMID- 9953773 TI - Measurement of the vector analyzing power in pi +-d elastic scattering at 0.74 GeV/c. PMID- 9953775 TI - Definite evidence of the Landau-Zener transition in nucleus-nucleus collisions. PMID- 9953776 TI - Radiative capture reaction 7Be(p, gamma )8B at low energies. PMID- 9953774 TI - 16O( gamma, pi +)16N reaction at 320 MeV photon energy. PMID- 9953777 TI - Effect of elastic transfer in sub-barrier fusion between similar nuclei. PMID- 9953778 TI - Recoil effects in the coordinate space Dirac equation. PMID- 9953779 TI - Need for new physics in statistical models of nuclear de-excitation. PMID- 9953780 TI - Six-quark clusters and the energy dependence of the ( pi +, pi -) reaction. PMID- 9953781 TI - sup3He+3He reaction cross sections at 17.9, 21.7, and 24.0 MeV. PMID- 9953783 TI - Nucleon-deuteron elastic scattering with the Paris nucleon-nucleon potential. PMID- 9953782 TI - Measurement of the 12C(n, gamma 0)13C cross section in the giant dipole resonance region. PMID- 9953784 TI - Neutron-proton capture at extreme angles at En PMID- 9953786 TI - Lippmann-Schwinger equation in a soluble three-body model: Surface integrals at infinity. PMID- 9953785 TI - Preequilibrium gamma rays with angular momentum coupling. PMID- 9953787 TI - 76Se(t,p)78Se reaction at 17 MeV. PMID- 9953788 TI - Trinucleon system in a two-body model: Coulomb effect on bound and scattering states. PMID- 9953789 TI - d5/2 isobaric analog state in 55Co. PMID- 9953790 TI - High spin states in 208Pb. PMID- 9953791 TI - Shell and odd-even effects on alpha-particle energy spectra from the (p, alpha ) reaction on nuclei around neutron number 50. PMID- 9953792 TI - Forward-to-backward asymmetry of the ( gamma,n) reaction in the energy range 20 30 MeV. PMID- 9953793 TI - Proton stripping to 8(-) stretched states in 60Ni. PMID- 9953794 TI - 73Ge(d,3He)72Ga reaction. PMID- 9953795 TI - Coulomb effects on the electron scattering radiation tail. PMID- 9953796 TI - Particle-core multiplets in 97Mo populated via the (3He,2n gamma ) reaction. PMID- 9953797 TI - Gamma ray spectroscopy in 103Pd. PMID- 9953798 TI - Computer simulations of fragmentation in nuclear reactions: A semiclassical model. PMID- 9953799 TI - Mass distributions from microscopic models of heavy ion collisions. PMID- 9953800 TI - Linear momentum transfer and light particle emission in the E/A=25 MeV 6Li+238U reaction. PMID- 9953802 TI - Cross section of 16O+16O near the Coulomb barrier. PMID- 9953801 TI - Neutron emission in the fissioning 158Er composite system. PMID- 9953803 TI - Coupled-channels analysis of silicon-nickel fusion reactions. PMID- 9953805 TI - Projectilelike fragments from 14N beams at 15, 25, and 35 MeV/nucleon. PMID- 9953806 TI - Decay properties of 150Tm and 150Er. PMID- 9953804 TI - Distributions of the total energy and multiplicity of gamma rays feeding the discrete yrast states in heavy-ion-induced fusion reactions. PMID- 9953807 TI - Spectroscopic applications of the (p, pi -) reaction. PMID- 9953808 TI - Reaction 16O( pi +, pp)14N at 60 MeV: Testing the quasi-deuteron mechanism. PMID- 9953809 TI - Fission induced in natU, natPb, 197Au, and 165Ho by 80 and 100 MeV pi + and pi - PMID- 9953810 TI - Theory of bremsstrahlung amplitudes in the soft-photon approximation. PMID- 9953812 TI - Relativistic treatment of 0(+)(p,p' PMID- 9953813 TI - Nucleon-nucleus inelastic scattering using a relativistic impulse approximation with exchange. PMID- 9953811 TI - Effect of pi d channel coupling on the medium energy nucleon-nucleon interaction. PMID- 9953814 TI - Fragmentation of hot quantum drops. PMID- 9953815 TI - y scaling in inclusive scattering. PMID- 9953816 TI - Elastic and inelastic scattering of 50-MeV pions from 28Si and 30Si. PMID- 9953817 TI - Pion-nucleon bremsstrahlung and Delta electromagnetic moments. PMID- 9953818 TI - Role of three-body unitarity in pi -N scattering. PMID- 9953819 TI - L2-L3 Coster-Kronig transition probability for Z=54. PMID- 9953820 TI - Half-life of tritium and the Gamow-Teller transition rate. PMID- 9953821 TI - Electric dipole collectivity in light nuclear systems. PMID- 9953822 TI - Nuclear binding and quark confinement. PMID- 9953823 TI - Comparison of SU(3) phenomenologies in the sd shell. PMID- 9953824 TI - Dynamical symmetry of the interacting boson model in light nuclei. PMID- 9953825 TI - Solvable model for one-dimensional nuclear matter: Simultaneous eigenstates of spin, isospin, and energy. PMID- 9953826 TI - Three-body potentials originating from cluster distortion. PMID- 9953827 TI - Algebraic analysis of physical and spurious states in Dyson boson mapping. PMID- 9953828 TI - Pairing effects at finite temperature: Fermionic and bosonic contributions to the specific heat of a nucleus. PMID- 9953830 TI - Angular momentum effects in preequilibrium cluster emission. PMID- 9953829 TI - Intermediate structures in the excitation functions of heavy ion fusion reactions. PMID- 9953831 TI - 7Li(p PMID- 9953832 TI - Angular momentum distribution in heavy ion fusion reactions. PMID- 9953833 TI - Role of correlations in the 3He(e,e' PMID- 9953834 TI - Electromagnetic production of heavy leptons in relativistic heavy ion collisions. PMID- 9953836 TI - Photodisintegration of deuteron at low energies: Isolation of electric and magnetic contributions. PMID- 9953835 TI - Deser-Goldberger-Baumann-Thirring formula for pi -p atoms. PMID- 9953837 TI - Testing interacting boson model cores through particle-core coupling: Negative parity states in the odd-mass Tl and Au isotopes. PMID- 9953838 TI - Number projection method. PMID- 9953839 TI - Molecular states in excited spectra of light nuclei. PMID- 9953840 TI - Erratum: Doorway states and cross-section fluctuations in the 12C PMID- 9953841 TI - Selective sequential 2n decay of 14C states populated by 13C+n. PMID- 9953843 TI - Medium effects in the nuclear Landau-Vlassov transport theory. PMID- 9953842 TI - Signature dependence observed for M1 transitions between rotational levels based on an f7/2 single-particle state in 163Dy. PMID- 9953844 TI - Parametrization of the coupled channels S matrix in the inelastic case: Relation to Arndt-Roper form. PMID- 9953845 TI - Search for high-spin states in 27Si and 27Al. PMID- 9953846 TI - Electroexcitation of 4(-) states in 16O. PMID- 9953847 TI - Lifetime of the lowest 0(+), T=1 state of 22Na. PMID- 9953848 TI - Quantal equivalent local potentials from resonating group method n+ alpha nonlocal interactions. PMID- 9953849 TI - Stability of angular extrapolation methods for determining the deuteron asymptotic D-state to S-state ratio. PMID- 9953850 TI - M1 radiation widths in 27Al. PMID- 9953851 TI - Effect of inelastic excitation on the elastic scattering of alpha particles from 144,148,150,152,154Sm at 120 MeV. PMID- 9953853 TI - Coupled-channel description of inelastic scattering from soft nuclei. PMID- 9953852 TI - Stellar krypton cross sections at kT=25 and 52 keV. PMID- 9953854 TI - Electromagnetic final state interactions in high energy nuclear collisions: Isobaric comparisons. PMID- 9953855 TI - Collective band structures in the gamma -soft nucleus 135Nd. PMID- 9953856 TI - Test of the triaxial rotor model and the interacting boson-fermion approximation model description of collective states in 193Ir. PMID- 9953857 TI - Model-independent analysis of heavy-ion elastic scattering. PMID- 9953858 TI - Exciton-model approach to fast-particle emission in heavy-ion collisions. PMID- 9953859 TI - Symmetric mass fragmentation following capture in reactions of 4.8-8 MeV/nucleon 208Pb on 50Ti, 52Cr, 58Fe, and 64Ni using the fusion model based on the dynamical fragmentation theory. PMID- 9953860 TI - Solution of the mean field equations for spontaneous fission. PMID- 9953861 TI - Delta production by pion charge exchange on complex nuclei. PMID- 9953863 TI - Correlation effects in the relativistic impulse approximation treatment of proton nucleus elastic scattering. PMID- 9953862 TI - Cascade model calculations of p PMID- 9953864 TI - Multiquark compound states and the triton charge form factor. PMID- 9953865 TI - Electromagnetic excitation of the delta resonance in nuclei. PMID- 9953866 TI - Nucleon-nucleon scattering with isobar degrees of freedom. PMID- 9953867 TI - Near-threshold (p PMID- 9953868 TI - Pion scattering to collective excitations in 90Zr and 118Sn. PMID- 9953869 TI - Electron-capture branching ratio of 81Krm. PMID- 9953870 TI - Weak pion-nucleon coupling strength: New constraint from parity mixing in 18F. PMID- 9953872 TI - Configuration mixing among 11/2(-) states in 19F. PMID- 9953871 TI - Effect of deuteron structure on hyperfine structure of deuterium. PMID- 9953873 TI - Rigid reflection-asymmetric rotor description of the nucleus 227Ac. PMID- 9953874 TI - Sensitivity of large-angle pion elastic scattering to medium modifications. PMID- 9953875 TI - Double charge exchange on 56Fe. PMID- 9953876 TI - Vector and tensor analyzing powers for the (d PMID- 9953877 TI - Approximate analytic expression for B(E2) values in the interacting boson model. PMID- 9953878 TI - Zero-temperature second random phase approximation and its formal properties. PMID- 9953879 TI - Discussion of the coexisting 0(+) band in the doubly closed subshell 96Zr on the basis of the polyspheron model. PMID- 9953880 TI - Comment on "Method for observation of neutrinos and antineutrinos" PMID- 9953881 TI - Erratum: Mechanism of the heavy-ion charge-exchange reaction 12C(12C,12)12B at 35 MeV/nucleon PMID- 9953882 TI - Heavy residue masses as possible indicators of the impact parameter in the reaction 20Ne+60Ni at 742 MeV. PMID- 9953883 TI - Line-shape analysis of high spin states: Collectivity in 166Yb. PMID- 9953884 TI - Interpretation of relativistic dynamical effects in proton-nucleus scattering. PMID- 9953885 TI - Microscopic prescriptions for elastic and inelastic scattering. PMID- 9953886 TI - Low-energy scattering theory for Coulomb plus long-range potentials. PMID- 9953889 TI - Theory of compound-nucleus reactions: Gaussian versus non-Gaussian statistics of its parameters. PMID- 9953888 TI - Cross sections for production of the 15.10-MeV and other astrophysically significant gamma-ray lines through excitation and spallation of 12C and 16O with protons. PMID- 9953887 TI - Spin-flip transitions in 16O and 18O excited by inelastic proton scattering. PMID- 9953890 TI - Photodisintegration of the deuteron with elliptically polarized gamma rays. PMID- 9953891 TI - Measurement of the analyzing power for n-p radiative capture. PMID- 9953892 TI - Elementary deconvolution method for the wave packet theory of collisions. PMID- 9953894 TI - Proton-90Zr interaction at sub-Coulomb proton energies. PMID- 9953893 TI - Low energy octupole resonance in 46Ti studied by inelastic proton scattering at 65 MeV. PMID- 9953895 TI - Masses of 77Kr and 75Kr. PMID- 9953896 TI - Transverse polarization transfer DNN(0 degrees) measurements for the (p,n) reaction on 58Ni and 90Zr at Ep PMID- 9953898 TI - Deuteron and entropy production in relativistic heavy ion collisions. PMID- 9953897 TI - Proton and deuteron inelastic excitation of the 1(+) state at Ex=5.846 MeV in 208Pb: Isoscalar character and importance of tensor correlations. PMID- 9953899 TI - Quantitative analysis of the relation between entropy and nucleosynthesis in central Ca + Ca and Nb + Nb collisions. PMID- 9953901 TI - Decay of instable Li, Be, and B fragments and the distortion of temperature measurements in heavy ion collisions. PMID- 9953900 TI - Search for shape isomers in 56Ni. PMID- 9953902 TI - Projectile-breakup and transfer-reemission reactions in the 12C+20Ne system. PMID- 9953904 TI - Quark model for nucleus-nucleus collisions. PMID- 9953903 TI - Unified semiquantal description of coupled-channels effects in fusion and elastic scattering of polarized heavy ions. PMID- 9953906 TI - Light fragment spectra to upper kinematic limits for 300 MeV proton reactions with Be and Ag. PMID- 9953905 TI - Mass dependence of pion double charge exchange. PMID- 9953907 TI - Delta resonance in nuclei. PMID- 9953908 TI - Delta (1232) production via charge-changing weak currents: e PMID- 9953909 TI - Pionic fusion and the clustering correlation. PMID- 9953910 TI - Excitation of the isobaric analog state of 165Ho by pion single-charge exchange. PMID- 9953911 TI - Neutron and proton matrix elements for 21+ transitions in T=1 nuclei from pion inelastic scattering. PMID- 9953912 TI - Pion elastic and inelastic scattering from 48,50Ti, 52Cr, and 54,56Fe at 180 MeV: Determination of neutron and proton multipole matrix elements. PMID- 9953913 TI - Crossing symmetric self-consistent pi N t matrix. PMID- 9953914 TI - Spin and isospin effects in a relativistic treatment of p PMID- 9953915 TI - Inelastic scattering of alpha particles on light nuclei at P alpha =7.0 GeV/c. PMID- 9953916 TI - Double-analog transition 48Ca( pi +, pi -)48Ti at 35 and 50 MeV. PMID- 9953917 TI - Quark-cluster effects in elastic electron-deuteron scattering. PMID- 9953918 TI - Peculiarity of the charge-exchange quadrupole excitation in nuclei. PMID- 9953919 TI - Microscopic relativistic description of proton-nucleus scattering. PMID- 9953920 TI - Semiphenomenological studies of the ground state binding energies of hypernuclei. PMID- 9953921 TI - Octupole state properties in 168Er and the two-neutron { PMID- 9953922 TI - Beta decay of 20O. PMID- 9953924 TI - Shape coexistence effects and superdeformation in 84Zr. PMID- 9953923 TI - Measurement of E0 transitions in neutron-rich nuclei near A=100. PMID- 9953925 TI - Coulomb effects in the 3He ground state. PMID- 9953926 TI - Nucleon-number-conserving description of pairing correlations in terms of occupation probability amplitudes. PMID- 9953927 TI - Deriving an interacting boson model from the fermion SO(8) model. PMID- 9953929 TI - Boson representations of fermion systems. PMID- 9953928 TI - Critical dynamics of highly viscous finite nuclear matter. PMID- 9953931 TI - Inclusion of a hard-core effect in the Thomas-Fermi method. PMID- 9953930 TI - Liquid-gas and superconducting phase transitions of nuclear matter calculated with real time Green's function methods and Skyrme interactions. PMID- 9953932 TI - Geometrized dynamics and search of structural instabilities in SU(2) models. PMID- 9953933 TI - Coulomb effects in the alpha-induced deuteron breakup. PMID- 9953934 TI - ( pi,p) reactions at low excitation energy. PMID- 9953936 TI - Isotope shift in erbium I by laser-atomic-beam spectroscopy. PMID- 9953935 TI - Pion double charge exchange on 12C at low energies. PMID- 9953937 TI - Search for a purported resonance in 13C at 20 MeV via analyzing power measurements of 12C(n,n). PMID- 9953938 TI - Precompound decay in heavy ion reactions via the hybrid model. PMID- 9953940 TI - Nucleon size and the attractive nuclear force. PMID- 9953939 TI - Calculation of coefficients of fractional parentage for large spaces. PMID- 9953941 TI - Continuum effects and the interpretation of Sigma hypernuclei. PMID- 9953942 TI - Polarization in pi N--> eta N and pi N phase-shift analyses. PMID- 9953943 TI - Evidence of multiplicity scaling of medium energy protons emitted in relativistic heavy ion collisions and antiproton annihilation in nuclei. PMID- 9953945 TI - Reduction of coupled equations for heavy ion reactions. PMID- 9953944 TI - Comment on "Test of Fermi gas model predictions of level density in 137Xe" PMID- 9953946 TI - No two-proton strength to 72Ge(02+). PMID- 9953948 TI - Temperatures, energies, and degree of thermal equilibration of fragments in damped nuclear reactions. PMID- 9953947 TI - 28Si PMID- 9953949 TI - 36-MeV-triton-induced charge exchange: Mass measurements and energy levels of neutron-rich nuclei and the charge exchange reaction mechanism. PMID- 9953950 TI - Possible experiments to distinguish between different methods of treating the Pauli principle in nuclear potential models. PMID- 9953951 TI - Coulomb sum rules in the relativistic Fermi gas model. PMID- 9953952 TI - Nuclear structure of 208Pb from 207Pb+n resonances. PMID- 9953953 TI - Nuclear excitation in positron-K-electron annihilation. PMID- 9953954 TI - Heavy-ion collision theory with momentum-dependent interactions. PMID- 9953955 TI - Physical interpretation of time-dependent Hartree-Fock density matrix for heavy ion scattering. PMID- 9953957 TI - Direct and fusion carbon reaction components in the 6Li+12C reaction at 30 MeV. PMID- 9953959 TI - n-p bremsstrahlung interpretation of high energy gamma rays from heavy-ion collisions. PMID- 9953956 TI - Trends of total reaction cross sections for heavy ion collisions in the intermediate energy range AB - Direct measurements of total reaction cross sections (sigma R) have been performed in the energy range of 10-300 MeV/nucleon for heavy ion collisions. A decrease of sigma R with increasing energy was observed for a wide range of masses of the colliding systems. The data suggest that sigma R reaches a minimum located around 300 MeV/nucleon independently of the projectile target combination. A dependence of sigma R on mass asymmetry of the svstem is also demonstrated. Trends of sigma R in this energy range are well reproduced by the predictions of a simple microscopic model based on individual nucleon-nucleon collisions. Our data have been employed in this framework to derive a new semi empirical parametrization of sigma R. Most of the experimental results in the intermediate and high energy range have been reproduced by this parametrization using a single energy-dependent parameter. PMID- 9953958 TI - Two-particle correlations at small relative momenta for 40Ar-induced reactions on 197Au at E/A=60 MeV. PMID- 9953960 TI - Equilibrium model for fusion and orbiting. PMID- 9953962 TI - Reaction mechanism of pn and d emission in certain heavy-ion-induced nuclear reactions. PMID- 9953961 TI - Mechanism of the (6Li, 6He) reaction at intermediate energies and its suitability as a spin probe. PMID- 9953963 TI - Fragment production in intermediate energy heavy ion reactions. PMID- 9953964 TI - Transfer mechanism for 3 alpha in heavy ion scattering. PMID- 9953965 TI - Widths of Sigma and Lambda hypernuclear states. PMID- 9953966 TI - Relativistic Faddeev theory of the pi NN system with application to pi d scattering. PMID- 9953967 TI - Polarized pion-deuteron breakup in the region of the 3,3 resonance. PMID- 9953968 TI - Recoil measurement of the spallation of gold by intermediate energy pions. PMID- 9953969 TI - ( gamma,p), ( gamma,pn), and ( gamma,pp) reactions on light nuclei in the Delta (1232) resonance region. PMID- 9953970 TI - Doorway states induced by quantum recoils. PMID- 9953971 TI - Shell-model description of the beta decay of the N=21 isotones 35Si and 36P. PMID- 9953972 TI - beta +/electron-capture decay of 192,194,196,198,200Bi: Experimental evidence for low lying 0+ states. PMID- 9953973 TI - Collective 2(+) states in the U(5) classical limit of the proton-neutron interacting boson model. PMID- 9953974 TI - Face-centered-cubic solid-phase theory of the nucleus. PMID- 9953975 TI - Simple parametrization for octupole states in spherical and weakly deformed heavy nuclei. PMID- 9953976 TI - Interacting boson-fermion limit of the SO(8) model of nuclei. PMID- 9953978 TI - Energy levels of the nucleus 166Ho. PMID- 9953977 TI - Reconstituting rotational band structure from deformed boson expansions: Generic treatment. PMID- 9953980 TI - Generating functions for the Racah decomposition. PMID- 9953979 TI - Deltas in hadron gas. PMID- 9953981 TI - Yrast states of 216Rn and the extent of a region of possible static intrinsic reflection asymmetry. PMID- 9953982 TI - Photoactivation of 111Cdm without a "nonresonant" contribution. PMID- 9953983 TI - Alpha emission at the Fermi energy. PMID- 9953984 TI - Electron capture decay of 81Krm. PMID- 9953986 TI - Nature of the 17 keV and associated levels in 168Tm. PMID- 9953985 TI - Non-hedgehog ansatz and the role of the omega meson in the chiral soliton models. PMID- 9953987 TI - Last members of the K pi =04+ alpha -cluster rotational band in 20Ne. PMID- 9953988 TI - Erratum: Major mechanism of photoactivation for the 115In( gamma, gamma ')115Inm process by 60Co gamma -ray irradiation PMID- 9953989 TI - Identification of new neutron-rich rare-earth isotopes produced in 252Cf fission. PMID- 9953990 TI - Exotic isoscalar dipole resonances in the Walecka model. PMID- 9953992 TI - Photons from heavy-ion collisions at Fermi velocity. PMID- 9953993 TI - Effects of center-of-mass motion in the resonating-group theory of romann+ alpha scattering. PMID- 9953991 TI - Boson fermion dynamical SU(3) symmetry for asymmetric deformation in odd mass nuclei. PMID- 9953994 TI - Class of Jost-like functions. PMID- 9953995 TI - Fusion-energy reaction 3H PMID- 9953996 TI - Photon scattering in the giant dipole resonance region of 16O. PMID- 9953997 TI - Gamow-Teller strength in the 26Mg(p,n)26Al reaction at 135 MeV and its fractionation into T= 0, 1, and 2 isospin channels. PMID- 9953998 TI - Measurements of relative angular distributions for the 2H PMID- 9953999 TI - Polarized proton scattering from 116,120,124Sn at 16 MeV. PMID- 9954001 TI - Semiclassical treatment of the nucleon-nucleus optical potential. PMID- 9954000 TI - Distribution of proton spectroscopic strengths in the odd-A Rb isotopes. PMID- 9954003 TI - Direct-reaction plus statistical-model analysis of the 52Cr(d,2n)52Mng,m reaction. PMID- 9954002 TI - 52Cr(p,n)52Mng,m and 52Cr(d,2n)52Mng,m excitation functions. PMID- 9954004 TI - Nucleon transport induced by two-body collisions. PMID- 9954005 TI - Higher-order coupling effects in low energy heavy-ion fusion reactions. PMID- 9954006 TI - Symmetric splitting for the system 32S+238U at energies near and below the barrier. PMID- 9954007 TI - Dilepton radiation from high temperature nuclear matter. PMID- 9954008 TI - Actinide production in 136Xe bombardments of 249Cf. PMID- 9954009 TI - Production and deexcitation of highly deformed 67Ga. PMID- 9954010 TI - Quasielastic processes in the 28Si + 208Pb reaction at 6 MeV/nucleon. PMID- 9954011 TI - Two-center shell model for deformed and arbitrarily orientated nuclei. PMID- 9954012 TI - Positron and electron peaks produced by sub-Coulomb barrier heavy-ion collisions. PMID- 9954013 TI - Energy and target dependence of projectile breakup effect in elastic scattering of 6Li. PMID- 9954014 TI - Fission mechanisms of 0.2 TeV uranium beams. PMID- 9954015 TI - Effective interaction analysis of 500 MeV (p PMID- 9954016 TI - Distorted-wave impulse approximation and coupled-channels analysis of inelastic pion scattering from 18O. PMID- 9954018 TI - Nonlocality in medium energy proton scattering. PMID- 9954017 TI - Total nuclear capture rates for negative muons. PMID- 9954019 TI - Hypernuclear currents in a relativistic mean-field theory. PMID- 9954021 TI - Nuclear structure dependence of the (p, pi +) reaction. PMID- 9954020 TI - Elastic and inelastic scattering of 362 MeV polarized protons from 40Ca. PMID- 9954022 TI - Measurement of the neutron-neutron scattering length ann with the reaction pi -d -> nn gamma in complete kinematics. PMID- 9954023 TI - Indication of pionic-atom anomalies in pion-nucleus elastic scattering. PMID- 9954024 TI - Relativistic quarks in one-dimensional periodic structures. PMID- 9954025 TI - Beta decay of 39Cl. PMID- 9954026 TI - Structure of 39Ar. PMID- 9954027 TI - 150.8 keV, E3 transition in 111Cdm and comparison of experimental and theoretical high multipole order internal conversion coefficients. PMID- 9954028 TI - Effective interaction for relativistic mean-field theories of nuclear structure. PMID- 9954029 TI - Theoretical description of low-lying K pi =1(+) states in deformed nuclei. PMID- 9954030 TI - Intruder-g.s. mixing in Cd nuclei. PMID- 9954032 TI - Energy dependence of inelastic proton scattering to the 3(-), 2.614 MeV state in 208Pb. PMID- 9954031 TI - Nucleon promotion in the 17O+12C reaction. PMID- 9954033 TI - Cross section of 27Al(n,2n)26Alg.s. near 14 MeV. PMID- 9954034 TI - Identification of 182Pb in 40Ca irradiations of 147Sm. PMID- 9954035 TI - Anisotropies in transfer-induced fission of 16O+232Th. PMID- 9954036 TI - g factor of the 21+ state in 140Ba and 142Ba. PMID- 9954037 TI - Erratum: Relativistic random-phase-approximation response function for quasielastic electron scattering in local density approximation PMID- 9954038 TI - Temperature-induced noncollective rotation in 166Er. PMID- 9954039 TI - Nuclear photoabsorption cross section: Collective and quasi-deuteron contributions. PMID- 9954041 TI - Calculation of two-step processes in the (e,e'p) reaction. PMID- 9954040 TI - Measurement of the tensor analyzing power T21in pi PMID- 9954042 TI - Lippmann's identities in a soluble three-particle model. PMID- 9954043 TI - Low-energy 2H(d, gamma )4He reaction and the D-state admixture in the 4He ground state. PMID- 9954044 TI - Potential model analysis of low energy 2H(d, gamma )4He fusion data. PMID- 9954045 TI - Microscopic calculations of 5He with realistic interactions. PMID- 9954046 TI - Short lifetimes in 30P. PMID- 9954047 TI - E2 transition in the reaction 2H( gamma,n)1H. PMID- 9954048 TI - Asymptotic boundary conditions for three-body breakup: Probable nonutility of the standard approach. PMID- 9954049 TI - Microscopic theory of the 8Be( alpha, gamma )12C reaction in a three-cluster model. PMID- 9954050 TI - Center-of-mass motion and Siegert's theorem. PMID- 9954051 TI - Inelastic electron scattering charge form factor of 4He. PMID- 9954052 TI - Influence of nuclear dynamics on neutron scattering from 194Pt. PMID- 9954053 TI - Search for peak structure in e++ Th collisions. PMID- 9954054 TI - Influence of the detection geometry in the analysis of experimental observables in projectile breakups. PMID- 9954055 TI - Projectile-like fragments from 20Ne + 197Au and the correlated energy transfer studied by counting the simultaneously emitted neutrons. PMID- 9954056 TI - Single-nucleon transfer reactions induced by 376-MeV 17O on 208Pb. PMID- 9954057 TI - Fission and quasifission in U-induced reactions. PMID- 9954058 TI - Time delay effects on K x-ray production probability in deep inelastic U + U and U + Pb nuclear reactions. PMID- 9954059 TI - Band crossings in the gamma -soft nucleus 136Nd. PMID- 9954060 TI - Classical simulations of heavy-ion collisions. PMID- 9954061 TI - Correlated fluctuations in the 89Y(19F,x)y excitation functions. PMID- 9954062 TI - Application of quantum theory of particle collisions to 16O + 16O reactions. PMID- 9954063 TI - Probing the direct step of relativistic heavy ion fragmentation: (12C,11B + p) at 2.1 GeV/nucleon with C and CH2 targets. PMID- 9954064 TI - Neutron decay of excited nuclear states in heavy ion collisions. PMID- 9954066 TI - Evolution of 4 pi observables in the Vlasov-Uehling-Uhlenbeck theory and the transverse momentum transfer as a barometer for hadronic matter. PMID- 9954065 TI - Energy and linear-momentum dissipation in the fusion reaction of 165Ho + 20Ne at 30 MeV/nucleon. PMID- 9954067 TI - Inelastic pion scattering from 12C. PMID- 9954068 TI - Unitary theory of pion photoproduction in the chiral bag model. PMID- 9954070 TI - Singularities in pi -N scattering amplitude in nuclear matter. PMID- 9954069 TI - Relativistic impulse approximation in an additive potential model. PMID- 9954071 TI - Contributions of two-gluon exchange diagrams to the NN spin-orbit interaction. PMID- 9954072 TI - Modification of nuclear beta decay by intense low-frequency electromagnetic waves. PMID- 9954073 TI - Beta and neutrino spectra in the decay of 8B. PMID- 9954074 TI - Decay of 83Zr and the low-energy level structure of 83Y. PMID- 9954076 TI - Pair transfer at high angular momenta. PMID- 9954075 TI - Rotational bands in near-vibrational systems. PMID- 9954077 TI - Electromagnetic properties of 6Li in a cluster model with breathing clusters. PMID- 9954079 TI - Self-consistent Hartree description of deformed nuclei in a relativistic quantum field theory. PMID- 9954078 TI - Sigma model calculations of neutron-rich nuclear matter. PMID- 9954080 TI - Compatibility of the nuclear shell and nucleon bag models. PMID- 9954081 TI - Test of the fermion dynamical symmetry model microscopy in the sd shell. PMID- 9954082 TI - Relativistic description of nuclear systems in the Hartree-Fock approximation. PMID- 9954083 TI - Calculation of geometrical structure coefficients for the trinucleon system with central and tensor interactions. PMID- 9954084 TI - On-line nuclear orientation of cesium isotopes and the magnetic moment of 118Csm. PMID- 9954085 TI - E0 strength in 12C from 6Li scattering. PMID- 9954087 TI - Nuclear shape deformations in 485-MeV 56Fe PMID- 9954086 TI - Half-lives of the actinide nuclei 225Th,226Th,223Ac, and 226Ac. PMID- 9954088 TI - Possible Ex PMID- 9954089 TI - Confirmation of the 2805-keV level of 38S. PMID- 9954091 TI - Compound nucleus temperatures from particle and gamma ray emissions: Effects due to the temperature dependence of the level density parameter. PMID- 9954090 TI - Low-frequency anomaly in 172Os moment of inertia. PMID- 9954092 TI - Pseudovector versus pseudoscalar theory in kaon photoproduction from nucleons and nuclei. PMID- 9954093 TI - M1 selection rules in the neutron-proton interacting boson model. PMID- 9954094 TI - Delta (1232) contribution to three-nucleon force. PMID- 9954096 TI - Dispersive contribution to the nucleus-nucleus potential. PMID- 9954095 TI - Sum rule for two-particle excitation processes in heavy-ion reactions. PMID- 9954097 TI - Reduced alpha transfer rates in a schematic model. PMID- 9954098 TI - Doorway model for three-nucleon pion absorption. PMID- 9954099 TI - Two nuclear phases and the proton-neutron force. PMID- 9954100 TI - Erratum: Phase shift analysis of 12C ion elastic scattering measured at very high energy PMID- 9954101 TI - Separable approximations to energy dependent potentials. PMID- 9954102 TI - Analytic Sturmian functions and convergence of separable expansions. PMID- 9954103 TI - Electroexcitation of discrete levels in 12C and 13C at high momentum transfers. PMID- 9954104 TI - Minimal substitution for isospin dependent potentials. PMID- 9954105 TI - (p PMID- 9954106 TI - Off-energy-shell behavior of realistic potential models. PMID- 9954107 TI - Analysis of primary electric dipole gamma rays from slow-neutron capture by Ca isotopes. PMID- 9954108 TI - Preequilibrium model analysis of (p,n) reactions on isotopes of Zr and Mo. PMID- 9954109 TI - Backward-angle anomaly in alpha +40Ca scattering and molecular vibrational states in 44Ti. PMID- 9954110 TI - Mixing of isoscalar and isovector magnetic dipole excitation modes in 206Pb and 208Pb: Case of electron scattering form factors. PMID- 9954111 TI - Calculation of pair production by 10 and 20 MeV photons. PMID- 9954113 TI - Microscopic distorted-wave approximation study of low-energy nucleon scattering from 89Y. PMID- 9954112 TI - Fine structure of resonance at Ex~ 14 MeV in 40Ca. PMID- 9954114 TI - Structure of unbound states in 29Si from neutron resonance spectroscopy of 28Si + n. PMID- 9954115 TI - Optimizing heavy ion experiments to probe dense nuclear matter. PMID- 9954116 TI - Collective band structures in the odd-proton nuclei 135,137Pm. PMID- 9954118 TI - Statistical giant dipole resonance decay of highly excited states of 63Cu. PMID- 9954117 TI - Zero-point fluctuations and the diffuseness of the nuclear surface. PMID- 9954119 TI - Microscopic analysis of projectile excitation for 18O+64Ni. PMID- 9954120 TI - Subbarrier interactions of the oxygen isotopes. PMID- 9954121 TI - In-plane light particle correlations in 40 MeV/nucleon C+C, Ag, Au, and 50 MeV/nucleon C+C reactions. PMID- 9954122 TI - Inelastic excitation and neutron transfer in the 13C-13C scattering with the molecular particle-core model. PMID- 9954123 TI - Elastic and inelastic scattering of 58Ni PMID- 9954124 TI - Kinetic equation of nuclear gas. PMID- 9954125 TI - Coriolis interaction and variable reflection asymmetry in fission vibrational resonances. PMID- 9954127 TI - Charge asymmetry of the nuclear interaction and neutron-neutron scattering parameters. PMID- 9954126 TI - Pion double charge exchange and nuclear correlations. PMID- 9954128 TI - Invariant light front perturbation theory. PMID- 9954130 TI - Dispersion relations and Castillejo-Dalitz-Dyson pole in the pi N P wave scattering amplitude. PMID- 9954129 TI - Neutron and proton matrix elements for transitions in 39K from pion inelastic scattering. PMID- 9954132 TI - Classification and construction of six-quark basis states from parity eigenfunctions for N-N processes. PMID- 9954131 TI - Nuclear force in the Skyrme model. PMID- 9954133 TI - Structure of S from nuclear production experiments. PMID- 9954134 TI - Nuclear reactions induced by pi - at rest. PMID- 9954135 TI - Decay of 80Zn: Implications for shell structure and r-process nucleosynthesis. PMID- 9954136 TI - Gamow-Teller beta decay of 29Na and comparison with shell-model predictions. PMID- 9954137 TI - Algebraic solution of a general quadrupole Hamiltonian in the interacting boson model. PMID- 9954138 TI - Alpha particle cluster states in fp-shell nuclei. PMID- 9954140 TI - Nucleus as a canonical ensemble: d/p ratio and entropy at high temperature. PMID- 9954139 TI - Nucleus as a canonical ensemble: Entropy and level density at low temperature. PMID- 9954141 TI - Nuclear ground-state properties and nuclear forces in the unitary-model-operator approach: Application to 16O. PMID- 9954142 TI - Feasibility of detecting neutrinoless double-beta decay between pairs of single beta emitters. PMID- 9954143 TI - Ir(t PMID- 9954144 TI - Observation of 149Tm decay to 149Er levels and beta -delayed proton emission. PMID- 9954146 TI - Shell effects in Pb(p,xn) preequilibrium neutron emission. PMID- 9954145 TI - Intermediate-mass fragments from nonbinary processes in the reaction of 14N on Ag at E/A = 35 MeV. PMID- 9954147 TI - Two-nucleon high-spin states, the Bansal-French model and the crude shell model. PMID- 9954148 TI - Constrained Thomas-Fermi approach to the nuclear compressibility of a hot finite system. PMID- 9954149 TI - Analysis of coherent pion photoproduction on the deuteron at large angles. PMID- 9954150 TI - Spurious components in the ideal boson states. PMID- 9954151 TI - Effective valence proton and neutron numbers in transitional A PMID- 9954152 TI - Temperature distributions in nuclear collisions: Brief discussion and simple example. PMID- 9954153 TI - Theory of the (n,p) reaction on 90Zr. PMID- 9954155 TI - Antiproton annihilation in light nuclei. PMID- 9954154 TI - Weak electron-induced charged current reactions in 12C at intermediate energies. PMID- 9954156 TI - Comment on "Test of microscopic three-boson force in a six-fermion system" PMID- 9954157 TI - Ultrarelativistic hypernuclei. PMID- 9954159 TI - 37Cl solar neutrino capture cross section. PMID- 9954158 TI - Importance of the deuteron quadrupole moment in sup2H PMID- 9954160 TI - Deuteron-nucleus elastic scattering: Solution of the standard model via the finite element method. PMID- 9954161 TI - Search for nonresonant capture in the 16O( alpha, gamma )20Ne reaction at low energies. PMID- 9954162 TI - Random phase approximation effects in the longitudinal response function of 12C. PMID- 9954163 TI - Photonuclear and atomic cross sections of 27Al between 3 and 38 MeV. PMID- 9954164 TI - Proton resonances in 24Mg from Ex=12.7 to 15.7 MeV. PMID- 9954165 TI - Nuclear reaction theory of resonances belonging to a rotational band. PMID- 9954166 TI - 111Ag utilizing the (3He, pn gamma ) reaction: A rotational nucleus with intermediate deformation. PMID- 9954167 TI - Photon scattering from 90Zr below neutron emission threshold. PMID- 9954169 TI - Internal and barrier wave interpretation of the oscillations of the fusion excitation function. PMID- 9954168 TI - 73Ge(t,p)75Ge at Et PMID- 9954170 TI - Lifetime and g-factor measurements of yrast states in 134Nd and 136Nd. PMID- 9954171 TI - Dynamical effects in the Coulomb expansion following nuclear fragmentation. PMID- 9954173 TI - Dynamics of direct transfer reactions induced by heavy ions in the Fermi energy domain. PMID- 9954172 TI - Velocity and angular distributions of evaporation residues from 32S-induced reactions. PMID- 9954174 TI - Observation of collective behavior in 110Sn. PMID- 9954175 TI - Resonance behavior in the 24Mg PMID- 9954176 TI - Spin density and the real part of the heavy-ion potential. PMID- 9954177 TI - Phase structure of excited baryonic matter in the relativistic mean field theory. PMID- 9954178 TI - Photoexcitation mechanisms and photofission cross section for Bi by 100-300 MeV quasi-monochromatic photons. PMID- 9954179 TI - Delta production in proton-nucleus scattering at intermediate energies. PMID- 9954180 TI - Differential range measurement of the interaction of 238U with 400 GeV protons. PMID- 9954182 TI - Total reaction cross sections of 50 and 65 MeV pions on nuclei. PMID- 9954181 TI - Energy dependence of the 12C(p, pi +)13C PMID- 9954184 TI - European Muon Collaboration effect in the hybrid quark-hadron model. PMID- 9954183 TI - Pion elastic and inelastic scattering from 51V at 180 MeV. PMID- 9954185 TI - Generalized impulse approximation for relativistic proton scattering. PMID- 9954186 TI - Momentum-space second-order optical potential for pion-nucleus elastic scattering. PMID- 9954187 TI - Decay of 100Sr and a "pairing-free" K pi =1(+) rotational band in odd-odd 100Y. PMID- 9954188 TI - E0 study of 0(+) states near 5 MeV in 208Pb. PMID- 9954190 TI - Variational bounds for the triton. PMID- 9954189 TI - Determination of the absolute K through O conversion coefficients of the 80-keV M4 transition in 193Irm. PMID- 9954191 TI - Charge dependence in the triton. PMID- 9954192 TI - Isovector pairing collective motion: Generator-coordinate-method approach. PMID- 9954193 TI - Fermion dynamical symmetry model of nuclei: Basis, Hamiltonian, and symmetries. PMID- 9954195 TI - Weak evidence for a nuclear Josephson effect in the 34S(32S, 32S) elastic scattering reaction. PMID- 9954194 TI - Interaction energy in infinite nuclear matter in the hybrid soliton model. PMID- 9954197 TI - Angular momentum saturation in the 209Bi( alpha,2n) reaction. PMID- 9954196 TI - Thermal cross section for 10B(n,t)2 alpha. PMID- 9954199 TI - Predictions for magnetic moments and beta -decay transition strengths for mirror nuclei. PMID- 9954198 TI - Neutral pion production cross sections in heavy ion collisions from 80 to 219 MeV/nucleon. PMID- 9954200 TI - Rotational structure of highly deformed 99Y: 536-keV band. PMID- 9954201 TI - Nucleon momentum distribution in 2H from y-scaling analysis of inclusive electrodisintegration. PMID- 9954202 TI - Classification of i-active states in an isospin-invariant fermion dynamical symmetry model. PMID- 9954203 TI - Comment on "Reduction of coupled equations for heavy ion reactions" PMID- 9954204 TI - Discussion of a new supersymmetry classification of nuclear levels in 195Pt. PMID- 9954205 TI - Erratum: Fusion-energy reaction 3H PMID- 9954206 TI - pi d elastic amplitudes in the 117-324 MeV region. PMID- 9954207 TI - Systematic evidence for degrees of freedom beyond the sd phenomenological interacting boson model. PMID- 9954208 TI - Rotational versus pseudo-L symmetries in the interacting boson-fermion-model description of deformed nuclei. PMID- 9954209 TI - Classical dynamical polarization effects due to Coulomb potential between deformed nuclei. PMID- 9954210 TI - Coupled K pi =0(+) and K pi =0(-) vibrations in 234U. PMID- 9954212 TI - 12C PMID- 9954211 TI - Ground-state photoneutron reactions in sup18O. PMID- 9954213 TI - Spectroscopy of 18O: Radiative capture, 14C( alpha, gamma )18O. PMID- 9954214 TI - 9B excited states and analysis of the 9Be(3He,t) spectra. PMID- 9954215 TI - Unified formulation of variational approaches and separable expansions for the solution of scattering equations. PMID- 9954216 TI - Absolute photoneutron cross sections for Zr, I, Pr, Au, and Pb. PMID- 9954217 TI - Photon scattering on 238U and the interpretation of near-threshold photofission resonances. PMID- 9954218 TI - Energy dependence of the optical-model potential for fast-neutron scattering from bismuth. PMID- 9954220 TI - Coulomb and nuclear excitation of giant dipole resonances in ( alpha, alpha ') inelastic scattering. PMID- 9954219 TI - Global optical potential for alpha particles with energies above 80 MeV. PMID- 9954221 TI - Preequilibrium (p,p') spectra for nuclei around neutron number 50. PMID- 9954222 TI - Proton and alpha emission in 20Ne+24Mg collisions below 10 MeV/nucleon. PMID- 9954223 TI - Fusion evaporation and fusion-fission with aligned 23Na ions at energies near and below the fusion barrier. PMID- 9954225 TI - Origin of the oscillations in the 12C+12C fusion excitation function in terms of internal and barrier waves. PMID- 9954224 TI - Distribution of reaction strength in 32S PMID- 9954226 TI - Fission and deep-inelastic scattering yields for 58Ni PMID- 9954227 TI - Angular distributions of high energy gamma rays from heavy-ion collisions via an n-p bremsstrahlung interpretation. PMID- 9954228 TI - Incomplete momentum transfer in the 40Ar+58Ni reaction. PMID- 9954230 TI - Folding model for sub-barrier interaction between alpha-type nuclei. PMID- 9954229 TI - Modified Glauber model for the description of elastic scattering between heavy ions. PMID- 9954231 TI - Measurement of Ann, Ano, and Aon for the reaction pp-->d pi PMID- 9954232 TI - Identification of the different orders of scattering in alpha -nucleus reactions. PMID- 9954233 TI - Spin polarization and spin alignment in hypernuclei. PMID- 9954234 TI - Collective excitation of 172Yb from inelastic alpha scattering at 36 MeV. PMID- 9954235 TI - Mass dependence of pion single-charge exchange to the isobaric analog state at 20 MeV. PMID- 9954236 TI - Unitary meson-exchange pi NN models: NN and pi d elastic scattering. PMID- 9954237 TI - Elastic scattering of 30 MeV positive and negative pions from nickel isotopes. PMID- 9954239 TI - Proton-induced spallation reactions between 300 MeV and 20 GeV. PMID- 9954238 TI - Double charge exchange to the double isobaric analog state at T pi ~292 MeV. PMID- 9954240 TI - Poincare invariant potential model. PMID- 9954241 TI - Conventional nuclear European Muon Collaboration effect in deep inelastic lepton nucleus scattering. PMID- 9954242 TI - Upper limits on the mixing of heavy neutrinos in the beta decay of 63Ni. PMID- 9954243 TI - Transition through triaxial shapes of the light samarium isotopes and the beta decay of 136,138,140Eu. PMID- 9954244 TI - Bound-state beta decay of highly ionized atoms. PMID- 9954245 TI - alpha -decay reduced width of 194Pb and low-spin levels in 194Tl populated in 194Pb beta decay. PMID- 9954246 TI - Level structure of 159Eu from the beta - decay of the recently discovered isotope 159Sm. PMID- 9954248 TI - Thermostatic properties of polarized nuclear matter. PMID- 9954247 TI - Realistic few-quasiparticle level densities in spherical nuclei. PMID- 9954249 TI - Soliton matter in the two-dimensional linear sigma model. PMID- 9954251 TI - Nuclear elasticity applied to giant resonances of fast rotating nuclei. PMID- 9954250 TI - Nuclear charge radii of proton-rich strontium isotopes. PMID- 9954252 TI - Truncation, statistical inference, and single-particle description. PMID- 9954254 TI - Pion production, pion absorption, and nucleon properties in dense nuclear matter: Relativistic Dirac-Brueckner approach at intermediate and high energies. PMID- 9954253 TI - Spectral distribution calculations of the level density of 24Mg. PMID- 9954255 TI - Photoneutron cross section for 29Si. PMID- 9954256 TI - Photodisintegration of 4He in the Delta region. PMID- 9954257 TI - Dynamic polarization potential for coupled-channels effects on the heavy-ion fusion reactions. PMID- 9954258 TI - Interaction of neutral kaons with nuclei and neutron distributions. PMID- 9954259 TI - Classical microscopic calculations of 16O+16O and 40Ca+40Ca fusion cross sections. PMID- 9954260 TI - Nuclear bound states of the eta 0 meson and pion double-charge-exchange reactions. PMID- 9954261 TI - Unknown hypernucleus emitted from the S-substitutional 1 Lambda 2C excited state. PMID- 9954262 TI - Comment on "Electroexcitation of M4 transitions in 17O and 18O" PMID- 9954263 TI - Reply to "Comment on 'Electroexcitation of M4 transitions in 17O and 18O' " PMID- 9954264 TI - Erratum: Gamow-Teller strength in the 26Mg(p,n)26Al reaction at 135 MeV and its fractionation into T=0, 1, and 2 isospin channels PMID- 9954265 TI - Erratum: Dirac equation with a separable potential PMID- 9954267 TI - Vacuum instability for model field theories. PMID- 9954266 TI - Observation of both h11/2 proton and neutron alignments in 139Pm. PMID- 9954268 TI - Core-polarization effects on stretched particle-hole excitations in closed shell nuclei. PMID- 9954269 TI - Correlations between observables in n-d scattering. PMID- 9954270 TI - Deformed nucleonic bags and nuclear magnetic properties. PMID- 9954271 TI - Isospin sum rule for nuclear photoabsorption: Effect of retardation. PMID- 9954272 TI - Neutron-deuteron scattering calculations with W-matrix representation of the two body input. PMID- 9954273 TI - 34S(p,n)34Cl reaction at 35 MeV and its microscopic distorted-wave Born approximation analysis: Stringent test of the shell model. PMID- 9954274 TI - Off-shell effects in the nucleon-nucleon-alpha system. PMID- 9954275 TI - High-resolution inelastic electron scattering from 17O. PMID- 9954277 TI - Use of splines to calculate resonance poles and Gamow states. PMID- 9954276 TI - Algebraic approach to the two-Skyrmion system. PMID- 9954279 TI - Tensor polarization of the deuteron as a test of quantum chromodynamics. PMID- 9954278 TI - Eigenvalue problem for Gamow vectors and a separable approximation for the N-N interaction. PMID- 9954280 TI - 90Zr(n,d)89Y reaction at 22 MeV. PMID- 9954281 TI - Inelastic proton scattering exciting the gamma -vibrational band in deformed nuclei (152 <= A <= 192) at 65 MeV and the systematics of the hexadecapole (Y42) strength of the gamma vibration. PMID- 9954282 TI - Fermi-surface anomaly for neutrons in yttrium. PMID- 9954283 TI - 112Cd from 110Cd(t,p). PMID- 9954285 TI - Core polarization and quenching in stretched spin states: Case study of the 9- Ex=3.522 MeV state in 116Sn. PMID- 9954284 TI - 89Y PMID- 9954286 TI - Spatial development of inelastic scattering and particle transfer cross sections in very heavy ion reactions. PMID- 9954287 TI - Similar rotational band structures in doubly-odd 136Pm and 134Pr. PMID- 9954289 TI - Magnetic properties of the 176Lu ground-state band. PMID- 9954288 TI - Excitation functions for production of heavy actinides from interactions of 16O with 249Cf. PMID- 9954290 TI - Search for high excitation energy structures in 90Zr and 208Pb, via 20Ne inelastic scattering. PMID- 9954291 TI - Nucleus-nucleus optical potential in an optimal approximation. PMID- 9954292 TI - Ultradipole photons in low-energy heavy-ion reactions. PMID- 9954293 TI - High-spin states in doubly-odd 130La. PMID- 9954294 TI - Effect of high spin states on fusion in heavy ion collisions. PMID- 9954295 TI - Sequential breakup cross section of 6Li PMID- 9954296 TI - Systematics of the release of residual nuclei from relativistic nucleus-nucleus interactions. PMID- 9954297 TI - Giant resonances in excited Sn isotopes. PMID- 9954298 TI - Thermal-neutron fission cross section of 26.1-min 235Um. PMID- 9954299 TI - Exchange effects and large angle proton scattering on light nuclei at intermediate energies: p+3He scattering. PMID- 9954300 TI - Quark compound bag model for NN scattering up to 1 GeV. PMID- 9954301 TI - Short range delta-nucleon interaction in pion-deuteron elastic scattering. PMID- 9954303 TI - Protonium and baryonium states with the Graz potential. PMID- 9954302 TI - Current conservation and interaction currents in relativistic meson theories. PMID- 9954304 TI - Inelastic pion scattering to low-lying excited states of 44Ca. PMID- 9954305 TI - Charge-symmetry breaking in neutron-proton elastic scattering. PMID- 9954307 TI - Systematics of angular-dependent neutron production by 585 MeV protons on targets with 12 <= A <= 238: Differential cross section measurements. PMID- 9954306 TI - Cancellations in axial-vector amplitudes and Ward-Takahashi relation. PMID- 9954308 TI - Systematics of angular-dependent neutron production by 585 MeV protons on targets with 12 <= A <= 238: Validation of intranuclear cascade-evaporation model calculations. PMID- 9954309 TI - Experimental search for nonstrange narrow isovector dibaryons. PMID- 9954310 TI - Tensor and vector spin observables in p-d elastic scattering at 600, 800, and 1000 MeV. PMID- 9954311 TI - Model for tunneling in many-particle systems. PMID- 9954312 TI - Green's function Monte Carlo study of light nuclei. PMID- 9954313 TI - Simple parametrization for low energy octupole modes of s-d shell nuclei. PMID- 9954315 TI - Model wave functions for the deuteron. PMID- 9954314 TI - Nucleon-nucleon tensor interaction and the triton binding energy. PMID- 9954316 TI - Quark cluster model for nuclear matter. PMID- 9954317 TI - Rotational model and shell model pictures of magnetic dipole excitations. PMID- 9954319 TI - Magnetic moments of 119Tem, 121Tem, and 123Tem. PMID- 9954318 TI - Collective magnetic multipole excitations in open shells: 48Ti. PMID- 9954320 TI - Nuclear orientation and nuclear magnetic resonance of 196Au in Fe. PMID- 9954321 TI - Geometrical representation of interacting boson models: U(3) model. PMID- 9954323 TI - Generator coordinate method approach to the dynamic group representation. PMID- 9954322 TI - Magnetic moments of excited states in the stable chromium isotopes. PMID- 9954325 TI - Extension of the yrast band in 74Se. PMID- 9954324 TI - Description of the K pi =1(+) isovector states within a generalized coherent state model. PMID- 9954326 TI - Search for double beta decay in 100Mo and 92Mo. PMID- 9954327 TI - Reactions with 40Ar and 84Kr leading to the same compound nucleus, 200Po. PMID- 9954328 TI - Search for sharp lines in e+-e PMID- 9954329 TI - Elastic scattering of 19.5 and 30 MeV negative pions from 12C. PMID- 9954330 TI - E0 decays of 0+ states in 146Gd: Search for two-phonon octupole excitations. PMID- 9954331 TI - Observation of vector analyzing power in elastic scattering of 150-MeV 6Li on 12C. PMID- 9954332 TI - Deuteron bremsstrahlung-weighted photonuclear sum rule. PMID- 9954333 TI - Pion multiplicities in dynamical models of heavy ion collisions. PMID- 9954334 TI - Microscopic optical-potential analysis of charge-symmetry violation in pi +/- elastic scattering from 3H and 3He 3He. PMID- 9954335 TI - Possible existence of new K pi =0(+) low-lying excited bands in 168Er. PMID- 9954336 TI - Dynamical symmetries in even-even Te nuclides. PMID- 9954337 TI - Effective Lambda NN interactions in light hypernuclei. PMID- 9954338 TI - Global optical potentials for elastic p+ 40Ca scattering using the Dirac equation. PMID- 9954339 TI - Evidence for predicted level crossing in doubly decoupled structures. PMID- 9954340 TI - Search for entrance-channel effects in the production of superdeformed nuclei. PMID- 9954342 TI - rho - omega mixing in nuclear charge asymmetry. PMID- 9954341 TI - Excitation of the Delta (3,3) resonance in compressed finite nuclei. PMID- 9954344 TI - Microscopic analysis of the 13C( alpha,n PMID- 9954345 TI - Transverse isoscalar excitations in 24Mg by 180 degrees electron scattering. PMID- 9954343 TI - Gamow-Teller and M1 strength in the 32S(p,n)32Cl reaction at 135 MeV. PMID- 9954347 TI - Properties of the E1 giant resonance built on the first excited state of 16O. PMID- 9954346 TI - Longitudinal response of three-body nuclei. PMID- 9954348 TI - Polarized, high-density, gaseous 3He targets. PMID- 9954349 TI - Unified description of the neutron-208Pb mean field between -20 and +165 MeV from the dispersion relation constraint. PMID- 9954350 TI - High spin states in 52Cr PMID- 9954351 TI - Level spectrum of 219Ra and weak coupling in the light actinide region. PMID- 9954352 TI - Inclusive two-particle correlations for 16O-induced reactions on 197Au at E/A=94 MeV. PMID- 9954353 TI - Band structure in 180Re and the different coupling schemes in a deformed doubly odd nucleus. PMID- 9954354 TI - Rotational bands in 133Ce. PMID- 9954355 TI - High spin states in 98Tc via the 94Zr(7Li,3n)98Tc reaction. PMID- 9954357 TI - Target residues from the interaction of copper with 35 MeV/nucleon 12C ions. PMID- 9954358 TI - High-spin excitations in the rotating frame and sudden approximations. PMID- 9954356 TI - Molecular single-particle effects in the 12C PMID- 9954359 TI - Applications of the extended Boltzmann-Uehling-Uhlenbeck model to participant and spectator dynamics. PMID- 9954360 TI - Level structure of 140Nd. PMID- 9954361 TI - Band crossings in even-even 138Sm and 134Nd. PMID- 9954362 TI - Viewing the liquid-gas phase transition by measuring proton correlations. PMID- 9954363 TI - Yield and recoil properties of iodine isotopes from the interaction of 240 MeV 12C with 238U. PMID- 9954364 TI - Interference effects between 17O states populated in the 13C(6Li,d)17O*--> alpha +13C reaction. PMID- 9954365 TI - Spectroscopy of high spin states in 73Br. PMID- 9954366 TI - Target asymmetry measurement in gamma d--> PMID- 9954367 TI - Medium energy proton scattering from 154Gd and the interacting boson model of nuclei. PMID- 9954369 TI - Quark model of the pi -pp--> PMID- 9954368 TI - Effect of neutron-proton mass difference on charge symmetry breaking in neutron proton elastic scattering. PMID- 9954370 TI - Electromagnetic interaction of an off-shell nucleon. PMID- 9954371 TI - Nucleon electromagnetic form factors from scattering of polarized muons or electrons. PMID- 9954372 TI - Meson-nucleus interactions using polarized nuclei. PMID- 9954373 TI - Deuteron properties of the coupled nucleon and isobar channels model. PMID- 9954374 TI - N Delta -NN interaction in the pionic disintegration of the deuteron. PMID- 9954375 TI - Effective hadron theories from a quark model. PMID- 9954376 TI - 228Th nuclear states fed in 228Ac decay. PMID- 9954377 TI - Electric monopole transitions in 122Te. PMID- 9954378 TI - Double K-shell ionization accompanying the internal conversion of the 0.166-MeV transition in 139La. PMID- 9954380 TI - Vibrational modes at finite temperature: Restoring force and mass parameters for multipole excitations. PMID- 9954379 TI - Reconstituting rotational band structure from deformed boson expansions: Model test. PMID- 9954382 TI - Quarks and the saturation properties of nuclear matter. PMID- 9954381 TI - Nuclear structure of light thallium isotopes as deduced from laser spectroscopy on a fast atom beam. PMID- 9954383 TI - Coexistence and B(E2)'s in even Ge nuclei. PMID- 9954384 TI - Systematics of light deformed nuclei in relativistic mean-field models. PMID- 9954385 TI - Shape changes and alignment properties in 77Kr. PMID- 9954387 TI - 3s1/2 spectroscopic strength distribution in 207Tl and 205Tl. PMID- 9954386 TI - SU(3) x SU(4) limit of an isospin invariant fermion dynamical symmetry model. PMID- 9954388 TI - Triaxiality in the proton-neutron interacting boson model: Systematic study of perturbations in the SU(3) limit. PMID- 9954389 TI - Triaxiality in the proton-neutron interacting boson model: Perturbed O(6) symmetry with application to the mass A PMID- 9954390 TI - Isovector excitations of N PMID- 9954391 TI - Excitation of the Delta (3,3) resonance in compressed finite nuclei from a constrained mean-field method. PMID- 9954392 TI - Determination of the collective Hamiltonian in a self-consistent theory of large amplitude adiabatic motion. PMID- 9954394 TI - Pionic fusion near threshold using the 208Pb(3He, pi -)211At reaction. PMID- 9954393 TI - Application of a theory of large amplitude collective motion to a generalized landscape model. PMID- 9954395 TI - 7Li(p PMID- 9954396 TI - Simultaneous population of large and small deformation bands at very high spin in 152Dy. PMID- 9954397 TI - Forward angle measurements of 60 MeV/nucleon 40Ar peripheral interactions on 208Pb. PMID- 9954398 TI - Significance of the 54Fe (n,p) measurement of the Gamow-Teller transition. PMID- 9954399 TI - Coupling between the isoscalar and isovector monopole resonances in N PMID- 9954401 TI - One- and two-step contributions to the 90Zr(p,n)90Nb cross section at 0 degrees. PMID- 9954402 TI - Comment on "Charge dependence of the nucleon-nucleon interaction due to the pion mass difference" PMID- 9954400 TI - Spectral distribution calculations using Wildenthal's universal sd interaction. PMID- 9954404 TI - Search for heavy-ion radioactivity from 241Am. PMID- 9954403 TI - Erratum: Theory of kaonic hydrogen PMID- 9954405 TI - Angular momentum dependence of complex fragment emission. PMID- 9954407 TI - Absolute gamma intensities in the A=98 transitional nuclei and shape coexistence in 98Y. PMID- 9954406 TI - Radioactive decay of 234U via Ne and Mg emission. PMID- 9954408 TI - Two-body exit channels in p PMID- 9954410 TI - Three-body breakup: Asymptotic behavior. PMID- 9954411 TI - 12C( gamma,n) cross section from 30 to 100 MeV. PMID- 9954409 TI - 1H(d PMID- 9954412 TI - Kemmer-Duffin-Petiau equations from two-body Dirac equations. PMID- 9954413 TI - Proton resonances in 32S from Ex=9.83 to 12.74 MeV. PMID- 9954414 TI - Unified treatment of bound-state and scattering problems. PMID- 9954415 TI - Nuclear structure of 48Ca. PMID- 9954417 TI - Coherent pickup and knockout contributions to the 144Nd(p, alpha )141Pr reaction. PMID- 9954416 TI - Proton occupation numbers in 206Pb from the (d PMID- 9954418 TI - High-spin states of (1f7/2)-2 character in 56,58,60,62Co. PMID- 9954419 TI - From binary breakup to multifragmentation: Computer simulation. PMID- 9954420 TI - Lifetimes of yrast and near-yrast states of 159,160,161Yb. PMID- 9954421 TI - Level structure of 83Zr. PMID- 9954422 TI - Elastic scattering of 210 MeV 6Li ions from 12C and 58Ni and unique 6Li-nucleus optical potentials. PMID- 9954423 TI - Analysis of damped and fusion processes in the 197Au+51V reaction at Elab PMID- 9954424 TI - Fragmentation of 16O projectiles at 100 MeV per nucleon. PMID- 9954425 TI - Multiplicity and bombarding energy dependence of the entropy in relativistic heavy-ion reactions. PMID- 9954426 TI - Excitation energy division in the quasielastic region from reactions of 12 MeV/nucleon 48Ti with 150Nd. PMID- 9954427 TI - Quasi-elastic processes in 58Ni- and 64Ni-induced reactions on Sn isotopes. PMID- 9954428 TI - Properties of kaon-photoproduction operator on nucleons and nuclei. PMID- 9954429 TI - S-wave optical potential in pionic atoms. PMID- 9954430 TI - 16O(p PMID- 9954431 TI - Relativistic effects in forward angle proton-nucleus elastic scattering. PMID- 9954432 TI - High momentum components in nuclei. PMID- 9954433 TI - Role of pair terms in NN scattering. PMID- 9954434 TI - Search for short lived neutral particle in the 15.1 MeV isovector transition of 12C. PMID- 9954435 TI - Intruder state collectivity at a double subshell closure from the beta decay of 0 96Yg to the levels of 96Zr. PMID- 9954437 TI - Intrinsic operators and wave functions for the interacting boson model. PMID- 9954436 TI - Basis for relativistic models of nuclear structure in field-theoretic models of the strong interaction. PMID- 9954438 TI - 10+ yrast isomer in 132Ba. PMID- 9954440 TI - Nuclear level density parameter-its dependence on spin and temperature. PMID- 9954441 TI - Fluctuations and the thermal mean-field approach. PMID- 9954439 TI - Potential description of the positive- and negative-energy properties of the alpha + 40Ca system and alpha -cluster structure of 44Ti. PMID- 9954442 TI - Systematic procedure for going beyond the time-dependent Hartree-Fock approximation. PMID- 9954443 TI - Tails of the rotational strength function in the nuclear quasicontinuum. PMID- 9954444 TI - Coulomb effects in asymptotic normalization constants: A soluble model. PMID- 9954445 TI - Configuration mixing and electromagnetic properties of odd-even nuclei. PMID- 9954446 TI - Estimate of the triton asymptotic D to S ratio. PMID- 9954448 TI - Low temperature kinetics of nuclear superfluids. PMID- 9954447 TI - Band structure in 133,135Pr. PMID- 9954449 TI - Complex scaling in the cluster model: Resonances in 8Be. PMID- 9954450 TI - Target/projectile mass dependence of light ion yields from heavy ion collisions. PMID- 9954451 TI - Four-fragment exit channel in the interaction of 1050 MeV 84Kr with U studied with mica detectors. PMID- 9954452 TI - Differential cross section and analyzing power measurements for p+p elastic scattering at 497.5 MeV. PMID- 9954453 TI - Calculation of energy levels of 232Th, 232-238U for the K pi =0(+) ground state bands. PMID- 9954454 TI - Active target production of muons for muon-catalyzed fusion. PMID- 9954456 TI - Yukawa theories in nuclear physics. PMID- 9954455 TI - Angular and spectral distributions for subthreshold pion production. PMID- 9954457 TI - Mass dependence of the semiclassical corrections in the treatment of the nucleon nucleus optical potential. PMID- 9954458 TI - Alpha particle cluster states in 40Ca. PMID- 9954460 TI - Energy and symmetry of states in light nuclei. PMID- 9954459 TI - Comment on "No two-proton strength to 72Ge(02+)" PMID- 9954462 TI - Breakup-fusion analysis of continuum spectra of alpha - and h-induced reactions. PMID- 9954461 TI - Octupole deformation in odd-odd nuclei. PMID- 9954463 TI - Structure of the 6Li-->p+(n alpha ) vertex: Three-body formalism. PMID- 9954465 TI - Structure of the 6Li-->p+(n alpha ) vertex: 6Li(e,e'p)n alpha reaction. PMID- 9954464 TI - Structure of the 6Li-->p+(n alpha ) vertex: 6Li(p,2p)n alpha reaction. PMID- 9954467 TI - Extension of the minimal three-nucleon model to the unphysical sheet of energy. PMID- 9954466 TI - Direct calculation of the S matrix in coordinate space. PMID- 9954468 TI - Ground state proton capture reactions from 20 to 100 MeV. PMID- 9954470 TI - Intrinsic radial sensitivity of nucleon inelastic scattering. PMID- 9954469 TI - E1 polarizability of 7Li and astrophysical S factor for 4He(t, gamma )7Li. PMID- 9954471 TI - Final-state electronic interactions in allowed beta decay. PMID- 9954473 TI - Effects of final-state interaction on the 12C(e,e'p PMID- 9954472 TI - Proton elastic scattering from 12C at 250 MeV and energy dependent potentials between 200 and 300 MeV. PMID- 9954474 TI - Ambiguity-free polarization measurements from mixture initial preparations. PMID- 9954476 TI - Low-lying states in 111In. PMID- 9954475 TI - Coexistence in the even zinc isotopes. PMID- 9954478 TI - 82Se(t,p)84Se reaction at 17 MeV. PMID- 9954477 TI - 93Nb(n,xp), natAg(n,xp), and natIn(n,xp) reactions at 14.1 MeV. PMID- 9954479 TI - Neutron capture cross section of 197Au: A standard for stellar nucleosynthesis. PMID- 9954480 TI - Non-yrast states in even-even 98Ru. PMID- 9954481 TI - 111Cd from the (3He,2n gamma ) reaction and a rotational interpretation. PMID- 9954482 TI - Collective and single particle structure in 103Rh. PMID- 9954483 TI - Observation of collective flow in relativistic nuclear collisions by transverse momentum analysis. PMID- 9954484 TI - Lateral ejection of low energy protons in high energy heavy-ion collisions. PMID- 9954485 TI - Identification of the (9/2(+) to (5/2(-) transition in 69Se. PMID- 9954487 TI - Momentum space simulation of proton spectra in heavy ion reactions. PMID- 9954486 TI - 28Si PMID- 9954488 TI - Light particle emissions in 12C+64Ni at E(12C)=35-70 MeV. PMID- 9954489 TI - Four-body calculation of the 0(+)-1(+) binding energy difference in the A=4 Lambda hypernuclei. PMID- 9954491 TI - Inelastic pion scattering from 13C at 65 MeV. PMID- 9954490 TI - Energy dependence of neutron-proton matrix element ratios derived from 25-800 MeV energy proton scattering. PMID- 9954493 TI - Total radiative capture rates for three- and four-nucleon pionic atoms. PMID- 9954492 TI - Relativistic treatment of (p,p' gamma ) reactions. PMID- 9954494 TI - Nuclear structure effects in double-beta decay. PMID- 9954495 TI - Triple angular correlations in the decay of 110Agm. PMID- 9954496 TI - Shell-model description of the beta - decay of the N=21 and 22 isotones 34Al, 36Si, and 37P. PMID- 9954497 TI - Branching ratios of 9C to low lying states in 9B. PMID- 9954499 TI - Neutron stars and the equation of state. PMID- 9954498 TI - Nuclear charge symmetry breaking and the 3H PMID- 9954500 TI - Effect of nuclear deformation on few-quasiparticle state densities. PMID- 9954501 TI - Systematics of B(E2;01+-->21+) values for even-even nuclei. PMID- 9954502 TI - Comparison of the symplectic shell model and Hartree-Fock results for excited 0(+) states of 4He. PMID- 9954503 TI - Band structure and determination of K quantum numbers for odd-odd systems in the interacting boson-fermion-fermion model. PMID- 9954504 TI - Microscopic approach to enforced SU(6) symmetry in random phase approximation. PMID- 9954505 TI - Effect of rotation on the isovector giant dipole resonance in certain calcium isotopes. PMID- 9954506 TI - Low-lying levels in 148Pm. PMID- 9954507 TI - Low-lying l=3 proton resonances in 50Cr PMID- 9954508 TI - Pion inelastic scattering from 48,50Ti, 52Cr, and 54,56Fe: Higher-lying states. PMID- 9954509 TI - Measurement of charged pion asymmetries in scattering of polarized electrons from polarized 3He. PMID- 9954510 TI - 20Ne PMID- 9954512 TI - Photons from ultrarelativistic nuclear collisions. PMID- 9954511 TI - Application of Gamow resonances to continuum nuclear spectra. PMID- 9954513 TI - Comment on "Low-frequency anomaly in 172Os moment of inertia" PMID- 9954514 TI - Comment on "Algebraic analysis of physical and spurious states in Dyson boson mapping" PMID- 9954515 TI - Comment on the characterization of the giant quadrupole resonance in 208Pb as reported from pi +/ pi - scattering. PMID- 9954516 TI - Signatures of initial- and final-state interactions in pion absorption. PMID- 9954518 TI - Erratum: Spectral distribution calculations of the level density of 24Mg PMID- 9954517 TI - Comment on "Trends of total reaction cross section for heavy ion collisions in the intermediate energy range" AB - The energy-dependent, semiempirical, surface transparency factor of Kox et al. is accurately represented by a simple analytical expression. Total reaction cross sections obtained using this parametrization agree with Kox's predictions to within four percent. PMID- 9954520 TI - Search for mixed-symmetry states in the O(6) nucleus 134Ba. PMID- 9954519 TI - Electroexcitation of high-multipolarity transitions in 140Ce. PMID- 9954521 TI - Low-energy pion double charge exchange on Ca isotopes. PMID- 9954522 TI - Spin-flip excitations in a schematic model. PMID- 9954523 TI - Evidence for dispersion relation corrections in inelastic nucleon scattering to the 3- state in 208Pb. PMID- 9954524 TI - 7Be(n,p)7Li total cross section from 25 meV to 13.5 keV. PMID- 9954525 TI - Coulomb Faddeev calculation of d+p-->p+p+n spectra near threshold and three-body effects. PMID- 9954526 TI - Off-shell properties of the two-nucleon t matrix. PMID- 9954527 TI - Possibility of new information about the N-N force in N-d polarization observables. PMID- 9954528 TI - Medium-spin states in 99Mo. PMID- 9954529 TI - Preequilibrium (n,n') cross sections on nuclei around atomic number 50 at En=14.1 MeV. PMID- 9954530 TI - Fragment spectra from reactions induced by 35 MeV/nucleon 14N on 165Ho. PMID- 9954531 TI - Angular momentum in a statistical formalism for complex particle emission. PMID- 9954532 TI - High spin structure in the odd-proton nucleus 133Pr. PMID- 9954533 TI - Heavy-ion optical potential for sub-barrier fusion deduced from a dispersion relation. PMID- 9954534 TI - Fluctuation and resonance analysis for 11B+12C, 7Li+16O, and 10B+13C induced reactions. PMID- 9954536 TI - Mean field effects in hot compressed nuclear matter. PMID- 9954535 TI - Relativistic nuclear fluid dynamics and Vlasov-Uehling-Uhlenbeck kinetic theory. PMID- 9954537 TI - Dissipation and forces in time-dependent Hartree-Fock calculations. PMID- 9954538 TI - 13C PMID- 9954539 TI - Interaction time evaluation in dissipative heavy ion reactions. PMID- 9954540 TI - Multifragmentation and dissociation in heavy ion collisions. PMID- 9954541 TI - Pion spectra in equilibrium models of nuclear collisions. PMID- 9954542 TI - Multiple alpha-transfer and dynamic Regge poles in anomalous large angle scattering. PMID- 9954543 TI - High-spin states of 99Ag and 100Cd. PMID- 9954545 TI - Skyrme force approach to intermediate energy proton scattering. PMID- 9954544 TI - Model for particle emission from a fissioning system. PMID- 9954547 TI - Realistic calculations for strangeness exchange at rest. PMID- 9954546 TI - Optical model for medium and high energy hadron-nucleus collisions. PMID- 9954548 TI - Dirac optical potentials constrained by a Dirac-Hartree approach to nuclear structure. PMID- 9954549 TI - Energy dependence of isovector and isoscalar 1+ excitations in 28Si PMID- 9954550 TI - Configuration dependence in calculations for pion inelastic scattering near N=28. PMID- 9954551 TI - Magnetic response of closed-shell +/-1 nuclei in Dirac-Hartree approximation. PMID- 9954553 TI - Relativistic random-phase approximation longitudinal response function for quasielastic electron scattering. PMID- 9954552 TI - Separable approximation method for two-body relativistic scattering. PMID- 9954554 TI - Elastic scattering of 19.5 and 30 MeV positive and negative pions from 40Ca. PMID- 9954555 TI - Comparison of 13C(p, pi -)14O and 13C(p, pi +)14C PMID- 9954556 TI - Relativistic impulse approximation description of polarized proton elastic scattering from polarized 13C. PMID- 9954557 TI - Relativistic folding model for intermediate energy deuteron-nucleus scattering. PMID- 9954558 TI - Beta decay properties of 148Er and 148Ho. PMID- 9954560 TI - Shell model nuclear matrix elements for double beta decay. PMID- 9954559 TI - Decays of 118In, 120In isomers to levels in 118Sn, 120Sn, and 122Sn. PMID- 9954561 TI - Temperature-dependent shell effects in 16O and 40Ca with a realistic effective Hamiltonian. PMID- 9954563 TI - Systematics of g factors in the neutron-rich 142,144,146Ba isotopes. PMID- 9954562 TI - Essential mechanisms in the triton binding. PMID- 9954564 TI - Effective interaction for N=50 isotones. PMID- 9954565 TI - Thermodynamic coefficients of hot nuclei. PMID- 9954566 TI - Geometrical structure and critical phenomena in the fermion dynamical symmetry model: SO(8). PMID- 9954567 TI - Fermion calculations in the boson space using the Dyson boson mapping. PMID- 9954568 TI - Light-particle multiplicity accompanying projectile breakup at 20 MeV/nucleon. PMID- 9954569 TI - Elastic and inelastic scattering of 0.8 GeV protons from 40Ar. PMID- 9954570 TI - Large angle p PMID- 9954571 TI - Unusual backward emission of multifragmentation products in ultrarelativistic nucleus-nucleus collisions. PMID- 9954572 TI - Measurement of the beta decay half-life of 17B. PMID- 9954573 TI - 48Ti PMID- 9954574 TI - 90Zr (p,n) and (n,p) distorted-wave impulse approximation cross sections in 2p2h random-phase approximation. PMID- 9954575 TI - E2(T=0) photofission of 236U and statistical calculations. PMID- 9954576 TI - Total Gamow-Teller strength and effect of configuration mixing and proton-neutron correlation in the even-even sd-shell nuclei. PMID- 9954578 TI - Reply to "Comment on 'Interpretation of relativistic dynamical effects in proton nucleus scattering.' " PMID- 9954577 TI - Comment on "Interpretation of relativistic dynamical effects in proton-nucleus scattering" PMID- 9954579 TI - Erratum: Band structure in 180Re and the different coupling schemes in a deformed doubly odd nucleus PMID- 9954580 TI - Analyzing powers for the reaction 2H PMID- 9954581 TI - Elastic scattering of 179.3 MeV antiprotons by deuterium. PMID- 9954582 TI - 50 MeV pion inelastic scattering to the 1+ doublet in 12C. PMID- 9954583 TI - Using the (p PMID- 9954584 TI - 12C PMID- 9954586 TI - p PMID- 9954585 TI - D-state amplitudes of three-nucleon systems using single-nucleon transfer reactions. PMID- 9954588 TI - Effect of polarization potential in proton-deuteron scattering. PMID- 9954587 TI - Influence of target clustering on exchange effects in internuclear interaction. PMID- 9954589 TI - Isospin splitting of the giant dipole resonance in the s-d shell and the interacting boson model. PMID- 9954591 TI - Isospin effects on the 15N PMID- 9954590 TI - Nucleon-nucleon scattering in a time-dependent treatment. PMID- 9954592 TI - Octupole deformation in 227Ac by single-proton stripping reactions: 226Ra( alpha, t)227Ac and 226Ra(3He,d)227Ac. PMID- 9954593 TI - Alpha scattering from 209Bi at 50.5 MeV. PMID- 9954594 TI - Form factors and transition charge densities for the quadrupole and hexadecupole electroexcitation of some 2p-1f shell nuclei. PMID- 9954596 TI - Pion production in a field theoretic description of hot compressed matter. PMID- 9954595 TI - Giant dipole resonances in excited Er isotopes. PMID- 9954597 TI - Comparison of Vlasov-Uehling-Uhlenbeck model with 4 pi heavy ion data. PMID- 9954598 TI - Quark-gluon plasma versus hadron gas. What one can learn from hadron abundances. PMID- 9954599 TI - Energy spectra of strange particles hadronizing from a quark-gluon plasma. PMID- 9954600 TI - Bubbles and drops in superheated and supercooled nuclear matter. PMID- 9954601 TI - Weak and strong signature splitting in doubly-odd 132Pr. PMID- 9954603 TI - Measurement of 12C, 16O, and 56Fe charge changing cross sections in helium at high energy, comparison with cross sections in hydrogen, and application to cosmic-ray propagation. PMID- 9954602 TI - Giant resonance excitations in projectile fragmentation at medium energies. PMID- 9954605 TI - J pi =6(+) molecular state below the barrier of the 12C PMID- 9954604 TI - Semiclassical theory of sub-Coulomb neutron transfer in collisions of deformed heavy ions and its application to the 238U PMID- 9954606 TI - Stochastic calculation of tunneling in systems with many degrees of freedom. PMID- 9954607 TI - Energy dependence of relativistic effects in the elastic scattering of polarized protons from 16O and 40Ca. PMID- 9954608 TI - Isospin distribution of quadrupole strength in 118Sn: Comparison with pion, nucleon, and electron scattering. PMID- 9954609 TI - Neutron-proton scattering observables at 325 MeV, the epsilon 1 parameter, and the tensor force. PMID- 9954610 TI - Structure of the low-lying 2+ states in 14C from inelastic pion scattering. PMID- 9954611 TI - (p,p' pi +) reaction at energies below 1 GeV. PMID- 9954612 TI - Neutron-proton final-state interaction in pi d breakup: Differential cross section. PMID- 9954614 TI - Transition densities in 30Si studied by electron scattering and coupled-channel calculations of 650 MeV proton scattering. PMID- 9954613 TI - Neutron-proton final-state interaction in pi d breakup: Vector analyzing power. PMID- 9954615 TI - Measurements of total and separated response functions of the deuteron through the quasielastic peak region for q PMID- 9954616 TI - Nonperipheral effects in medium energy proton scattering on collective nuclear states. PMID- 9954617 TI - Radiative muon capture in nuclei. PMID- 9954619 TI - Effect of a D-state admixture in the alpha particle on the B Lambda value of Lambda 5He. PMID- 9954618 TI - Extension of the Bonn meson exchange NN potential above pion production threshold: Nucleon renormalization and unitarity. PMID- 9954620 TI - From resonances to surface waves in pi +-p scattering. PMID- 9954621 TI - Reduced alpha widths for nuclei with N >= 84,Z <= 84. PMID- 9954622 TI - Fermi nuclear matrix element of allowed isospin-hindered positron decay of 56Co. PMID- 9954623 TI - Relations between Gamow-Teller and magnetic dipole transitions. PMID- 9954624 TI - Rotational collectivity in shell-model wave functions for A=20-28 nuclei. PMID- 9954625 TI - Orthogonalization of correlated states. PMID- 9954626 TI - Neutron strengths of the unbound 2h11/2, 1j13/2, and 1k17/2 shell-model states in 209Pb. PMID- 9954627 TI - Effects of direct nucleon-nucleon interactions in pion-condensed neutron star matter. PMID- 9954628 TI - Bethe-Salpeter calculation of three-nucleon observables with rank-one separable potentials. PMID- 9954629 TI - Finite particle number effects and the relationship of the fermion dynamical symmetry model with the Nilsson model. PMID- 9954630 TI - Pairing vibrations in semimagic even nuclei. PMID- 9954631 TI - Possibility of isospin breaking in the deuteron. PMID- 9954632 TI - Proton radiative capture by 15N, 16O, 27Al, and 28Si. PMID- 9954634 TI - Front-form Hamiltonian dynamics of deuteron electrodisintegration. PMID- 9954633 TI - Onset of deformation in Pb isotopes at high excitation energies. PMID- 9954636 TI - Speed of sound in asymmetric nuclear matter with Skyrme interactions. PMID- 9954635 TI - Valence p-n interactions and sufficient conditions for the development of collectivity in heavy nuclei. PMID- 9954637 TI - Direct versus sequential four-particle transfer in heavy ion collisions with superfluid nuclei: Sn+Sn reaction. PMID- 9954638 TI - Comment on "Feasibility of detecting neutrinoless double-beta decay between pairs of single-beta emitters" PMID- 9954639 TI - Reply to "Comment on 'Feasibility of detecting neutrinoless double-beta decay between pairs of single-beta emitters' " PMID- 9954640 TI - F-spin multiplets and alpha-transfer systematics. PMID- 9954641 TI - Evolution of mass and charge asymmetry in damped heavy-ion reactions. PMID- 9954642 TI - Energy dependence of the mean-field potential for neutron scattering from 190,192Os and 194,196Pt. PMID- 9954644 TI - Ab initio approach to the deuteron in the Skyrme-Witten model. PMID- 9954643 TI - Electromagnetic transitions in neutron-rich 40Cl. PMID- 9954645 TI - Measurements of cross sections relevant to gamma -ray line astronomy. PMID- 9954646 TI - 20F via 21Ne(t, alpha )20F reaction. PMID- 9954647 TI - Coincidence 16O(e PMID- 9954648 TI - Coulomb excitation of 144,146,148,150Nd. PMID- 9954650 TI - Low- and high-spin excited states in 139Pr. PMID- 9954649 TI - Levels and transitions in 204Pb and the four valence neutron-hole configurations. PMID- 9954652 TI - F-spin vector effects in inelastic electron scattering from low-lying collective states of 154Gd. PMID- 9954651 TI - Inelastic electron scattering from 64Ni. PMID- 9954653 TI - Total nuclear reaction probabilities for 2 to 6 MeV/nucleon d and 3He in Si. PMID- 9954654 TI - Nuclear structure of 200Pt from in-beam conversion-electron and gamma -ray spectroscopy. PMID- 9954656 TI - Effect of a steep gradient in the potential energy surface on nucleon exchange. PMID- 9954655 TI - Pion interferometry in ultrarelativistic heavy-ion collisions. PMID- 9954657 TI - Unexpected large deformations in 60Ni nuclei produced in the reaction 120 MeV 30Si PMID- 9954658 TI - Band structures in doubly odd 130Pr. PMID- 9954659 TI - Levels in 99Pd populated by the 96Ru( alpha,n) and (6Li,p2n) reactions. PMID- 9954660 TI - One-nucleon stripping reactions to discrete levels induced by a 480 MeV 12C beam on a 208Pb target. PMID- 9954661 TI - Properties of intermediate width structure in 12C(12C,12C)12C(O2+). PMID- 9954663 TI - Two-parameter liquid drop describing symmetric fission. PMID- 9954662 TI - Detailed balance description of energetic photons in heavy-ion collisions. PMID- 9954664 TI - Measurement of the spin correlation parameters All and Asl for the reaction pp- >d pi + in the energy region 500-800 MeV. PMID- 9954666 TI - Hamiltonian light-front dynamics of elastic electron-deuteron scattering. PMID- 9954667 TI - Time-delay analysis of the interpretation of narrow Sigma -hypernuclear states as bound states in the continuum. PMID- 9954665 TI - Elastic and inelastic scattering of 0.8 GeV polarized protons from 24Mg and 26Mg. PMID- 9954669 TI - Quasielastic proton-nucleus scattering in a relativistic plane-wave impulse approximation. PMID- 9954668 TI - Relativistic Faddeev calculation of K+d scattering. PMID- 9954670 TI - Proton-induced inclusive pion production from light nuclei in the region of the Delta 1232 resonance. PMID- 9954671 TI - Pion inelastic scattering to the three lowest 2+ states of 18O. PMID- 9954672 TI - Influence of collision centrality upon participant protons in d+C, alpha +C, and C+C interactions at 4.2 GeV/c per nucleon. PMID- 9954674 TI - Covariant approach to pi +-proton bremsstrahlung. PMID- 9954675 TI - y scaling in a simple quark model. PMID- 9954673 TI - Spin dependence of pp inelasticities at intermediate energies. PMID- 9954677 TI - Approximations for double-beta-decay formulas. PMID- 9954676 TI - Variation with the mass number of the oscillator spacing and of other quantities for a hyperon in hypernuclei. PMID- 9954678 TI - Statistical decay of the E1 giant resonance. PMID- 9954679 TI - Interacting boson-fermion model analysis of beta decay in A=195 and 197 nuclei. PMID- 9954680 TI - Quenching of gA in the nuclear medium. PMID- 9954682 TI - Dynamic symmetries in deformed odd-even nuclei. PMID- 9954681 TI - K capture in the decay of 131Ba. PMID- 9954684 TI - Statistical shape fluctuations in 166Er. PMID- 9954683 TI - Decoupling a collective degree of freedom from a model for tunneling in many particle systems. PMID- 9954686 TI - Skeleton boson realizations of collective subalgebras. PMID- 9954685 TI - Monopole strength as a measure of nuclear shape mixing. PMID- 9954687 TI - Microscopic derivation of boson-fermion Hamiltonians. PMID- 9954688 TI - t expansion and the Lipkin model. PMID- 9954690 TI - Parity violating mechanisms in nuclei. PMID- 9954689 TI - Boson representations of fermion systems: Proton-neutron systems. PMID- 9954691 TI - Search for the exotic nucleus 10He. PMID- 9954692 TI - 0 degrees polarization transfer in (p,n) reactions from 6,7Li and 9Be near 55 MeV. PMID- 9954694 TI - Analyses of nucleon spectra in heavy ion reactions. PMID- 9954693 TI - Equations-of-motion treatment of pairing correlations: Seniority-one states. PMID- 9954695 TI - Fusion of 32S + 27Al and 19F + 40Ca and the nucleus-nucleus potential. PMID- 9954696 TI - Generator coordinate method for spin-isospin projection in the chiral-bag-plus Skyrmion hybrid model. PMID- 9954697 TI - Quenching of magnetic strength in N=28 nuclei. PMID- 9954698 TI - Analytical number-projected BCS nuclear model. PMID- 9954699 TI - Physical content of pseudopotential interactions. PMID- 9954700 TI - Electron-induced weak processes in 12C and the behavior of the cross section near the maximal angle. PMID- 9954701 TI - Momentum dependence, Boltzmann-Uehling-Uhlenbeck calculations, and transverse momenta. PMID- 9954702 TI - Time-dependent Hartree-Fock calculation of the escape width of the giant monopole resonance in 16O. PMID- 9954704 TI - Approximate sum rules for inclusive breakup reactions. PMID- 9954703 TI - Exact and approximate sum rules for inclusive breakup reactions. PMID- 9954705 TI - Erratum: Angular and spectral distributions for subthreshold pion production PMID- 9954706 TI - Depopulation of the isomeric state 180Tam by the reaction 180Tam PMID- 9954707 TI - Relativistic Vlasov-Uehling-Uhlenbeck model for heavy-ion collisions. PMID- 9954708 TI - Giant E1 resonances in 20Ne observed with the 19F(p PMID- 9954709 TI - Electric quadrupole strength in 16O from the 15N(p PMID- 9954711 TI - 2H(d, gamma )4He reaction from a microscopic point of view. PMID- 9954710 TI - Electric quadrupole strength in 20Ne from the 19F(p PMID- 9954712 TI - Determination of the neutron electric form factor from 1H PMID- 9954713 TI - Low-energy neutron-proton analyzing power and the new Bonn potential and Paris potential predictions. PMID- 9954715 TI - 114Cd from 112Cd(t,p). PMID- 9954714 TI - Sum rule approach to the study of statistical decay properties of nuclear giant resonances. PMID- 9954716 TI - Evidence for state dependence of the imaginary part of the empirical optical potential. PMID- 9954717 TI - Systematics of continuum angular distributions: Extensions to higher energies. PMID- 9954718 TI - Level structure of the doubly-odd 242Am nucleus. PMID- 9954719 TI - Structure of 112In nucleus. PMID- 9954721 TI - Strong photon strength in 40Ar between 8 and 11 MeV. PMID- 9954720 TI - Excitation of giant resonances in 28Si with 250 MeV protons. PMID- 9954722 TI - Ground state M1 strengths of d5/2-1 levels in 39K. PMID- 9954723 TI - Evidence for Gaussian statistics in the compound nucleus: Case of overlapping resonances. PMID- 9954724 TI - Nuclear excitation and precompound nuclear reactions. PMID- 9954725 TI - Quantum molecular dynamics approach to heavy ion collisions: Description of the model, comparison with fragmentation data, and the mechanism of fragment formation. PMID- 9954726 TI - Neutrons in coincidence with intermediate mass fragments at large angles from 14N+Ag reactions at E/A=20 and 35 MeV. PMID- 9954728 TI - Strongly dissipative processes in the 28Si PMID- 9954727 TI - Numerical method for the calculation of continuum excitation amplitudes in time dependent external field problems. PMID- 9954729 TI - Sources of light particles from fusion-like processes in the 20Ne PMID- 9954730 TI - Projection operator model for heavy-ion resonance parameters below the Coulomb barrier and its application to 12C PMID- 9954731 TI - High spin levels populated in multinucleon-transfer reactions with 480 MeV 12C. PMID- 9954732 TI - Mechanisms for light charged particle emission in the reactions 247 and 337 MeV 40Ar+natAg. PMID- 9954733 TI - Large-angle correlations between 4He and 1,2,3H or 4He in the reactions 247 and 337 MeV 40Ar+natAg: Unexpected properties of the nuclear stratosphere. PMID- 9954735 TI - Optical potentials for p-shell heavy ion projectiles. PMID- 9954736 TI - Dispersions in semiclassical dynamics. PMID- 9954734 TI - Signature dependence of M1 and E2 transition probabilities for the i13/2 rotational band in 161Dy. PMID- 9954738 TI - Fragmentation of carbon ions at 250 MeV/nucleon. PMID- 9954737 TI - Spectroscopy of neutron-rich nickel isotopes: Experimental results and microscopic interpretation. PMID- 9954739 TI - Level densities and barriers of deformed 59Cu nuclei with 28 PMID- 9954741 TI - Nuclear stratosphere formation and its effects upon statistical particle emission processes. PMID- 9954740 TI - Transition from quasi-elastic to deep-inelastic reactions in the 48Ti PMID- 9954742 TI - Delta-hole model in the local-density approximation. PMID- 9954743 TI - Neutrino reactions on oxygen and a proposed measurement of the Weinberg angle. PMID- 9954744 TI - Medium effects in ( pi, pi ' gamma ) angular correlations on 12C(2(+)). PMID- 9954745 TI - Laser-assisted internal conversion. PMID- 9954746 TI - beta +-electron-capture decay of 69Se. PMID- 9954748 TI - Decay of 101Sr and the rotational structure of 101Y. PMID- 9954747 TI - Delayed proton emission of N=81 odd-odd precursors: 148Ho, 150Tm, and 152Lu. PMID- 9954749 TI - beta - gamma angular correlations in 20Na and 20F beta decay. PMID- 9954750 TI - Equation of state from nuclear and astrophysical evidence. PMID- 9954751 TI - Reflection-asymmetric rotor model of odd A~219-229 nuclei. PMID- 9954752 TI - Application of the multiphonon method to the study of the vibrational states with K=0 in heavy deformed nuclei. PMID- 9954753 TI - Correspondence between the fermion dynamic symmetry model and the interacting boson model in wave functions. PMID- 9954755 TI - Nuclear polarization and charge moments of 208Pb from muonic x rays. PMID- 9954754 TI - Extended thermal random phase approximation equation for nuclear collective excitation at finite temperature. PMID- 9954756 TI - Deformed odd-odd 180,182,184Re isotopes in the interacting-boson model. PMID- 9954757 TI - Trinucleon magnetic moments: 34-channel results. PMID- 9954758 TI - Trinucleon asymptotic normalization constants: Comparison of 3He and 3H. PMID- 9954759 TI - 3H and 3He solutions for momentum-dependent potentials. PMID- 9954761 TI - Low-spin states of 198Pt from (p,p' gamma ) measurements. PMID- 9954760 TI - Internal transformation brackets and quasi-Euler angles in hyperspherical formalism of four-body systems. PMID- 9954762 TI - Magnetic moments of the first excited 2+ states of the even-even Te isotopes. PMID- 9954764 TI - First observation of the (6Li,8He) reaction. PMID- 9954763 TI - Location of the low-energy isoscalar octupole resonance in 58Ni. PMID- 9954765 TI - Excitation function of the 15.11 MeV (1+,T=1) state in 12C from ( pi, pi ' gamma ) angular correlations. PMID- 9954766 TI - Decay of 3 sec 160Hom. PMID- 9954768 TI - Systematics of isotope production rates. PMID- 9954767 TI - Relativistic deuteron-nucleus scattering in the Kemmer-Duffin-Petiau formalism. PMID- 9954770 TI - Emission temperature and source radii inferred from two-particle correlation measurements in nuclear collisions. PMID- 9954769 TI - Eigenvalue problem of the resonating-group norm operator with mixed cluster states. PMID- 9954771 TI - Schematic Thomas-Fermi model for atomic nuclei. PMID- 9954772 TI - Realistic estimates for promptly emitted particles. PMID- 9954773 TI - Comment on "Radiative capture reaction 7Be PMID- 9954775 TI - Pre-scission neutron multiplicity following the 16O PMID- 9954774 TI - Erratum: Nucleon-number-conserving description of pairing correlations in terms of occupation probability amplitudes PMID- 9954776 TI - Gamma-ray energy correlations from nuclei at very high spins. PMID- 9954777 TI - Bipolar harmonic reduction formulae. PMID- 9954778 TI - Wave equation for a composite nucleon. PMID- 9954779 TI - Long range local effective potential for a three-particle system. PMID- 9954780 TI - Phase shift analysis of 0-30 MeV pp scattering data. PMID- 9954781 TI - Effective interaction for nucleon-nucleus scattering based on a one-boson exchange model. PMID- 9954783 TI - Coupling of the giant dipole resonance to gamma vibrations. PMID- 9954782 TI - Levels of the four lowest two-particle configurations in 210Po studied by in-beam gamma -ray and conversion-electron spectroscopy with the 209Bi PMID- 9954784 TI - Damping of the continuum response from 2p-2h excitations. PMID- 9954785 TI - Spin-isospin nuclear responses with hadronic probes. PMID- 9954786 TI - Collective motion in nucleus-nucleus collisions at 800 MeV/nucleon. PMID- 9954787 TI - Preequilibrium emission and incomplete fusion of low and medium mass heavy ion systems. PMID- 9954789 TI - High energy gamma rays from the 12C+12C and 40Ar+48Ti systems at 15 MeV/nucleon. PMID- 9954788 TI - Angular correlations near the Fermi energy. PMID- 9954791 TI - K+/ pi + enhancement in heavy-ion collisions. PMID- 9954790 TI - Target mass dependence of neutron emission in collisions with 35 MeV/nucleon 14N ions. PMID- 9954792 TI - Inclusive neutron spectra at 0 degrees from Nb-Nb and Au-Au collisions at 800 MeV/nucleon. PMID- 9954793 TI - N/Z equilibration in damped collisions induced by E/A=8.5 MeV 58Ni and 64Ni on 238U. PMID- 9954795 TI - Unified theory of gamma d-->np, pi 0d, pi NN, and pp-->pp gamma and the chiral bag model. PMID- 9954794 TI - Cross section for the 12C(139La,X)11C reaction at relativistic energies. PMID- 9954796 TI - Inelastic proton scattering at 200 to 400 MeV for 24Mg and 28Si in a microscopic framework. PMID- 9954797 TI - Energy dependence of the charge asymmetry A(T pi, theta ) in pi d elastic scattering. PMID- 9954798 TI - Energy dependence of T20 and tau 21 in pi d PMID- 9954799 TI - Unexpected recoil systematics of intermediate energy spallation products. PMID- 9954801 TI - Gamow-Teller decay of 80Zn: Shell structure and astrophysical implications. PMID- 9954800 TI - Contribution of the second kind of meson exchange current to pion-nucleus double charge-exchange reactions 18O( pi +, pi -) 18Ne(g.s) and 14C( pi +, pi -)14Og.s. PMID- 9954803 TI - beta -decay rate of 79mSe and its consequences for the s-process temperature. PMID- 9954802 TI - Test of the singly magic character of the N=50 isotone 83As populated in 83Ge decay. PMID- 9954805 TI - Rotational g factors of osmium isotopes at low spins. PMID- 9954804 TI - Decay of 143Ba to levels of the odd-proton N=86 nuclide 143La. PMID- 9954806 TI - Ground-state energy of nuclear matter. PMID- 9954807 TI - Collective rotational transverse current multipoles: Even-even nuclei. PMID- 9954808 TI - Bag-model nuclear equation of state in the Wigner-Seitz approximation. PMID- 9954809 TI - Global interpretation of low-energy octupole states in spherical and weakly deformed Z>28 nuclei. PMID- 9954810 TI - Convection currents in nuclei in a relativistic mean-field theory. PMID- 9954811 TI - Effect of surface fluctuations on the nuclear density. PMID- 9954813 TI - Cluster-orbital shell model and its application to the He isotopes. PMID- 9954812 TI - Optimal parametrization for the relativistic mean-field model of the nucleus. PMID- 9954815 TI - sdg interacting-boson model in the SU(3) scheme and its application to 168Er. PMID- 9954814 TI - Symmetry-preserving higher-order terms in the O(6) limit of the interacting boson model. PMID- 9954816 TI - Calculations of many-particle-many-hole deformed state energies: Near degeneracies, deformation condensates. PMID- 9954818 TI - Integrodifferential equation for few- and many-body systems. PMID- 9954817 TI - Momentum space Faddeev calculation of 3He binding energy with N-N P and D waves. PMID- 9954820 TI - Nuclear matter problem in the relativistic Green's function approach. PMID- 9954819 TI - Interpretation of atomic mass systematics in terms of the valence shells and a simple scheme for predicting masses. PMID- 9954821 TI - Charge radii in the 50 <= N,Z <= 82 region. PMID- 9954822 TI - Weak-coupling description of intruder states. PMID- 9954823 TI - Quark-exchange contribution to the European Muon Collaboration effect in nuclear matter. PMID- 9954824 TI - Bifurcation sets of the self-consistent flow in generalized SU(2) models. PMID- 9954825 TI - Bremsstrahlung from 16O PMID- 9954826 TI - Excitation of positive-parity states in 10B with the 13C(p, alpha )10B reaction. PMID- 9954827 TI - Role of tensor forces in the 4He(d PMID- 9954828 TI - Proton and neutron transition densities in 6,7Li from low energy neutron and proton scattering. PMID- 9954830 TI - Population of the metastable state of 111Cd via photoactivation by 60Co source. PMID- 9954829 TI - ( alpha,n) reaction to high spin states in 14N and 27Si. PMID- 9954831 TI - Nucleus 136Sm and the transition to a deformed regime at N=76-74. PMID- 9954833 TI - Spin determination from the angular distributions of identical colliding nuclei. PMID- 9954832 TI - Fusion, deep-inelastic collisions, and neck formation. PMID- 9954834 TI - Functional integral approach to the Lipkin model. PMID- 9954835 TI - Proton-rich exotic heavy nuclei: Self-consistent calculations. PMID- 9954837 TI - Comparison of effective charges derived in two different boson mappings. PMID- 9954836 TI - Damping of quadrupole motion in time-dependent density-matrix theory. PMID- 9954838 TI - Hamiltonian hierarchy and the Hulthen potential. PMID- 9954839 TI - Inclusive meson cross sections and quark clusters in nuclei. PMID- 9954840 TI - 2H(d PMID- 9954841 TI - Possibility of pions emitted in the spontaneous fission of 252Cf. PMID- 9954842 TI - Effect of entrance channel asymmetry on fusion reactions leading to compound nuclei with A=40,42. PMID- 9954844 TI - Deformed nuclear state as a quasiparticle-pair condensate. PMID- 9954843 TI - Entropy in 12C PMID- 9954845 TI - Proton distortion effects and meson exchange current contributions in the (e,e'p) reaction. PMID- 9954846 TI - Electron scattering form factors of stretched transitions using Woods-Saxon wave functions. PMID- 9954847 TI - Model analysis of the effect of elementary degrees of freedom in the 3S1 nucleon nucleon system. PMID- 9954849 TI - Compton scattering off the deuteron at low and intermediate energies. PMID- 9954848 TI - S-matrix pole trajectories for Yukawa potentials. PMID- 9954851 TI - Activation cross section and isomeric cross-section ratio for the 93Nb(n, alpha )90Ym,g process. PMID- 9954850 TI - Excited states of 139Ce from (p,n gamma ) reactions on lanthanum. PMID- 9954852 TI - Reactions 50Cr(p, gamma )51Mn and 50Cr(p,p' gamma )50Cr from 2.5 to 3.1 MeV. PMID- 9954853 TI - Isomeric cross-section ratio for the formation of 73m,gSe in various nuclear processes. PMID- 9954854 TI - Electron-pair creation on uranium by 10 and 20 MeV photons. PMID- 9954855 TI - Electroexcitation of 8- states in 52Cr. PMID- 9954856 TI - Level structure of 101Ru from the 100Ru(d,p) reaction. PMID- 9954857 TI - Resolution of potential ambiguities through farside angular structure: Data summary. PMID- 9954859 TI - Shape coexistence effects and quasiparticle alignment in 81Sr. PMID- 9954858 TI - Resolution of potential ambiguities through farside angular structure: Semiclassical analysis. PMID- 9954860 TI - Stripping- and pickup-induced breakup in 11- and 17-MeV/nucleon 20Ne+197Au reactions. PMID- 9954861 TI - Statistical E1 and M1 gamma strength functions from heavy-ion, xn gamma data. PMID- 9954862 TI - Mass of 39Sc via the 40Ca PMID- 9954864 TI - Hypernucleus formation in high-energy nuclear collisions. PMID- 9954863 TI - alpha -transfer contribution to 10B PMID- 9954866 TI - Angular correlation function as a detector for two-step processes. PMID- 9954865 TI - Collective flow and pion production in a hydrodynamic model. PMID- 9954867 TI - Optimal polynomial theory applied to 0-350 MeV pp scattering. PMID- 9954868 TI - Model dependence of charge-symmetry breaking in the neutron-proton interaction. PMID- 9954869 TI - Pion-induced nucleon knockout from polarized nuclei. PMID- 9954870 TI - Charge distribution and charge correlation in the annihilation of antiprotons on nuclei. PMID- 9954872 TI - ( gamma,pp-bar) as a probe of the Dirac negative energy bound states. PMID- 9954871 TI - Inclusive electron scattering from 2H,3He, and 4He. PMID- 9954873 TI - Fragment emission in the interaction of 238U with 400 GeV protons. PMID- 9954874 TI - Lambda N rho coupling and nonmesonic decay of heavy Lambda hypernuclei. PMID- 9954875 TI - Charge symmetry breaking in the reaction np-->d pi 0. PMID- 9954876 TI - Observations of hyperon-nucleus systems produced on 12C and 7Li targets using the (K-, pi +) reaction at 715 MeV/c. PMID- 9954877 TI - Cluster model theory of the Lambda 9Be hypernucleus. PMID- 9954878 TI - Observation of pionic atom anomaly in low-energy pion scattering. PMID- 9954879 TI - Reaction pi -p--> gamma n below the Delta resonance. PMID- 9954881 TI - Rare decays of cadmium and tellurium. PMID- 9954880 TI - Reaction pi -p--> pi 0n below the Delta resonance. PMID- 9954882 TI - Gamma decays of isobaric analog states relevant to neutrino detection. PMID- 9954884 TI - 14C beta decay and the 14N M1 form factors. PMID- 9954883 TI - Decay of 139,141,143Xe to levels of 139,141,143Cs. PMID- 9954885 TI - Half-life measurements for neutron-rich Tc, Ru, Rh, and Pd isotopes. Identification of the new isotopes 111Tc, 113Ru, and 113Rh. PMID- 9954886 TI - Shell model predictions for 19N PMID- 9954887 TI - Pairing, temperature, and deformed-shell effects on the properties of superdeformed 152Dy nucleus. PMID- 9954888 TI - Structure of Os and Pt isotopes. PMID- 9954889 TI - Structure of even-even Dy nuclei in the interacting boson model with two quasiparticle states. PMID- 9954890 TI - Symmetry-restoring treatment of the pairing Hamiltonian in the quasiparticle representation. PMID- 9954892 TI - Temperature-dependent shape transition in 166Er. PMID- 9954891 TI - Core-plus-alpha-particle states of 20Ne and 16O in terms of vibron models. PMID- 9954894 TI - Structure of N=88 isotones in the interacting-boson-plus-one-fermion-pair model. PMID- 9954893 TI - Coexistence or strong-mixing of intruder 0+ states in even-even Zr nuclei. PMID- 9954895 TI - Trinucleon asymptotic normalization constants with the new Bonn potential. PMID- 9954897 TI - Equation of state for dense nucleon matter. PMID- 9954896 TI - Nuclear equation of state from the nonlinear relativistic mean field theory. PMID- 9954898 TI - Nature of the equivalence between gamma instability and rigid triaxiality for finite boson number. PMID- 9954899 TI - Approximation for shell-model level densities. PMID- 9954900 TI - Shell-model calculations of isovector electromagnetic transitions and Gamow Teller beta decays in the N PMID- 9954901 TI - Clustered quark matter at finite temperature. PMID- 9954902 TI - Semiclassical analysis of the SO(3,1) S matrix. PMID- 9954904 TI - Evidence of alpha correlation from binding energies in medium and heavy nuclei. PMID- 9954903 TI - Nonlocal separable potential in the one-dimensional Dirac equation. PMID- 9954905 TI - Origin of the 13C PMID- 9954906 TI - Systematic features in the structure of doubly odd nuclei around A PMID- 9954907 TI - Erratum: Protonium and baryonium states with the Graz potential PMID- 9954908 TI - Superdeformation in 104,105Pd. PMID- 9954909 TI - Shape transitions in hot rotating 158Yb nuclei. PMID- 9954910 TI - Particle-hole stretched states excited in the 26Mg(p,n)26Al reaction at 134 MeV. PMID- 9954911 TI - Neutron-deuteron breakup calculations with W-matrix representation of the two body input. PMID- 9954912 TI - Singlet deuteron production in the 4He(d,p alpha )n reaction at 7 MeV. PMID- 9954913 TI - Quasifree proton knockout reaction in the distorted wave impulse approximation. PMID- 9954914 TI - 25Mg(3He,d)26Al to high spin states. PMID- 9954915 TI - Differences in the mirror reactions 3H(p, gamma )4He and 3He(n, gamma )4He from an isospin conserving nuclear force. PMID- 9954916 TI - Important configurations in six-quark N-N states. PMID- 9954918 TI - g9/2 isobaric analog state in 55Co. PMID- 9954917 TI - Elastic deuteron scattering and optical model parameters at energies up to 100 MeV. PMID- 9954919 TI - Highest spin n-p states in heavy nuclei via the ( alpha,d) reaction at 218 MeV. PMID- 9954920 TI - Electron scattering studies of the ground state rotational band of 152Sm. PMID- 9954921 TI - Medium energy gamma rays in nuclear reactions. PMID- 9954922 TI - Experimental limit for the circular polarization of the 1081 keV gamma ray in 18F. PMID- 9954923 TI - Distribution of excitation energy in the 505 MeV 56Fe+165Ho reaction. PMID- 9954924 TI - Higher-order pair-conversion peaks in heavy-ion collisions. PMID- 9954925 TI - Production of pions and light fragments in 0.8A GeV La PMID- 9954926 TI - Spin-spin effects through nuclear reorientation in elastic scattering of deformed heavy ions. PMID- 9954928 TI - Estimation of fusion time in heavy-ion collisions. PMID- 9954927 TI - Population of high spin states by quasi-elastic and deep inelastic collisions. PMID- 9954929 TI - Neutron-induced fission of the 26 min 235U isomer. PMID- 9954930 TI - Pion-nucleus double charge exchange and the nuclear shell model. PMID- 9954931 TI - Extraction of signals of a phase transition from nuclear multifragmentation. PMID- 9954932 TI - 7Li(p PMID- 9954933 TI - Elastic scattering of 50 MeV pi +/- from 58Ni, 60Ni, and 64Ni. PMID- 9954935 TI - Radiative pion capture and pion photoproduction in a chiral bag model. PMID- 9954934 TI - Hypernuclear production by the ( pi +,K+) reaction. PMID- 9954936 TI - "Optimal" approximation and the realistic nucleon-nucleon interactions. PMID- 9954937 TI - Quark distributions in nuclei. PMID- 9954938 TI - Lifetimes of N=Z nuclei 66As and 70Br. PMID- 9954940 TI - Application of a cubic barrier in exotic decay studies. PMID- 9954939 TI - Search for the l-forbidden beta decay 207Tl-->207Pb(570 keV). PMID- 9954941 TI - Analysis of magnetic dipole transitions between sd-shell states. PMID- 9954942 TI - beta vibrations in the O(6) limit of the proton-neutron interacting boson model. PMID- 9954943 TI - Mesic retardation and the triton binding energy. PMID- 9954944 TI - Competing coexistence models in medium-mass nuclei. PMID- 9954945 TI - Quark model and the triton. PMID- 9954946 TI - Approximate analytic self-consistent solution of the Overhauser problem for T >= 0. PMID- 9954947 TI - Sharing of collective multipole strength in the nuclear particle-hole model. PMID- 9954948 TI - Matrix elements of shell model Hamiltonians in multiple angular momentum coupling schemes. PMID- 9954949 TI - Semiclassical description of the pairing force matrix elements at finite rotational frequencies. PMID- 9954950 TI - Microscopic boson description of proton-neutron systems: Application to elastic and inelastic electron scattering from 18O and 20Ne. PMID- 9954951 TI - Geometrical structure and critical phenomena in the fermion dynamical symmetry model: Sp(6). PMID- 9954952 TI - Perturbative treatment of imaginary potential in 12C PMID- 9954954 TI - Response function of nuclear matter. PMID- 9954953 TI - Quadrupole scattering of 135 MeV protons by 9Be. PMID- 9954956 TI - Exact multistep distorted-wave method. PMID- 9954955 TI - Microscopic theory of backbending in some neutron-rich palladium isotopes. PMID- 9954957 TI - Comment on "p-barp--> Lambda -bar Lambda reaction in the one-gluon-exchange and the 3P0 models" PMID- 9954959 TI - Beta decay of 154Lu and 154Yb. PMID- 9954958 TI - Erratum: Poincare invariant potential model PMID- 9954960 TI - Decay of a new 16.7 min isomer of 131Sb. PMID- 9954962 TI - Preliminary selection of candidates for shape isomerism from even-even nuclei with masses A<208. PMID- 9954961 TI - Nuclear mean free path in the relativistic sigma - omega model. PMID- 9954963 TI - Superfluid tunneling in the restoration of parity conservation in octupole deformed nuclei. PMID- 9954964 TI - Multiconfiguration resonating-group study of scattering and reaction cross sections in the seven-nucleon system. PMID- 9954965 TI - Single-nucleon pickup spectroscopic factors for levels in 30Si and 30P and the D state of three-nucleon systems. PMID- 9954966 TI - Electroexcitation of 4He in the near continuum. PMID- 9954967 TI - Scattering of polarized and unpolarized nucleons from 28Si. PMID- 9954968 TI - Arrangement channel approach to exchange processes: Quasisymmetric and symmetric representations. PMID- 9954969 TI - Relativistic nucleon-nucleon interaction consisting of an attractive scalar and a repulsive vector. PMID- 9954970 TI - Deuteron photodisintegration. PMID- 9954972 TI - Total cross section and resonance spectroscopy for n+86Kr. PMID- 9954971 TI - Analog (p,n) cross sections of the zirconium isotopes at 18 and 25 MeV. PMID- 9954973 TI - Negative parity states of even-A Pt isotopes from proton inelastic scattering. PMID- 9954975 TI - E4 properties in deformed nuclei and the sdg interacting boson model. PMID- 9954976 TI - Alpha-particle emission from fast-neutron-induced reactions on neodymium isotopes. PMID- 9954974 TI - Measurements and a direct-reaction-plus-Hauser-Feshbach analysis of 89Y(p,n)89Zr, 89Y(p,2n)88, and 89Y(p,pn)88Y reactions up to 40 MeV. PMID- 9954977 TI - Unusual behavior of projectile fragments produced by the interactions of relativistic Ar ions with copper. PMID- 9954978 TI - Quantum mechanical coupled channels calculation of the 208Pb+238U(0(+),2(+),.,40(+)) reaction. PMID- 9954980 TI - Predictions of the macroscopic model of nuclei: Barriers to fusion and to light fragment emission. PMID- 9954979 TI - Optical model and coupled-channels analyses of the elastic and inelastic scattering of 18O from 28Si at 352 MeV. PMID- 9954981 TI - Gamma decay of high spin states in 25Mg above 6.1 MeV. PMID- 9954982 TI - Electromagnetic dissociation of 59Co and 197Au targets by relativistic 139La projectiles. PMID- 9954983 TI - Sources of light-charged-particle emission in the reaction 480 MeV 56Fe+natAg. PMID- 9954985 TI - Charge and mass distributions from the reaction of 240 MeV 12C ions with 238U. PMID- 9954984 TI - Boltzmann master equation analysis of preequilibrium neutron emission from heavy ion collisions at 35 MeV/nucleon. PMID- 9954987 TI - Nucleon transfer to continuum states. PMID- 9954986 TI - Covariant Boltzmann-Uehling-Uhlenbeck approach for heavy-ion collisions. PMID- 9954988 TI - Fragment angular momenta in alpha-induced fission of 238U. PMID- 9954989 TI - Unified theory of gamma N--> pi N, pi pi N, and pi N--> pi N, pi pi N reactions. PMID- 9954990 TI - Scaling in electron scattering from a relativistic Fermi gas. PMID- 9954991 TI - Nuclear reactions of 48Ti, 56Fe, 57Fe, 58Ni, 60Ni, 63Cu, and 65Cu by 12-GeV protons. PMID- 9954992 TI - Charge-symmetry-breaking corrections to pseudoscalar meson-nucleon coupling constants due to up-down current quark mass difference and their effects on NN scattering lengths. PMID- 9954994 TI - First-forbidden 0(+)-->0(-),1(-) electron capture of 44Ti. PMID- 9954993 TI - Extension of the Bonn meson exchange NN potential above pion production threshold: Role of the delta isobar. PMID- 9954995 TI - Activation of 115Inm by single pulses of intense bremsstrahlung. PMID- 9954997 TI - Random phase approximation for light nuclei based on fully relativistic Hartree Fock calculations. PMID- 9954996 TI - Half-life of 163Ho. PMID- 9954998 TI - Quasiparticle model for nuclear dynamics studies: Ground-state properties. PMID- 9954999 TI - Alpha particle structure. PMID- 9955001 TI - Pseudo-Hamiltonian approach to a theory of effective interactions in the particle hole channel: Microscopic foundations. PMID- 9955000 TI - Pseudo-Hamiltonian approach to a theory of effective interactions in the particle hole channel: Phenomenology. PMID- 9955002 TI - Three-dimensional, spherically symmetric, saturating model of an N-boson condensate. PMID- 9955003 TI - Variable moment of inertia in the interacting boson model. PMID- 9955004 TI - Shell effects in hot isobaric nuclei. PMID- 9955006 TI - Excitation energy of the 1.74 MeV state in 10B. PMID- 9955007 TI - Feasibility of measurement of the electromagnetic polarizability of the bound nucleon. PMID- 9955005 TI - Fine structure in 153Tm alpha decay. PMID- 9955008 TI - Multimodal fission and neutron evaporation. PMID- 9955009 TI - Isospin relaxation in the reaction 98Mo + 98Mo at 14.7 MeV/nucleon. PMID- 9955010 TI - Isovector and isotensor Coulomb energies for 61 <= A <= 209. PMID- 9955011 TI - Magnetic moment of the deuteron and quark degrees of freedom. PMID- 9955012 TI - 11Ba( alpha,p)14C*(Ex=23.288 MeV) reaction and (p, pi +) production mechanisms. PMID- 9955013 TI - Correlations between high energy gamma rays and light fragments in heavy ion collisions. PMID- 9955014 TI - Electromagnetic production of kaons. PMID- 9955016 TI - Electron peaks in e++Th, U, and Ta interactions. PMID- 9955015 TI - Dirac coupled channels calculation for p+40Ca inelastic scattering using the relativistic impulse approximation. PMID- 9955017 TI - Observation of a nuclear rainbowlike phenomenon in the (3He,t) charge-exchange reaction. PMID- 9955018 TI - 8Li from the 9Be(t, alpha )8Li reaction. PMID- 9955019 TI - Measurement of the 4He( gamma,p)3H total cross section and charge symmetry. PMID- 9955021 TI - Nonresonant capture of low-energy protons by 27Al. PMID- 9955022 TI - Convergence features in the pseudostate theory of the d+ alpha system. PMID- 9955020 TI - Radiative muon absorption in oxygen. PMID- 9955023 TI - 22Na(n,p)22Ne and 22Na(n, alpha )19F cross sections from 25 meV to 35 keV. PMID- 9955025 TI - Apparent violation of isospin symmetry in the 3H(3He,2H)4He reaction. PMID- 9955026 TI - Three-state mixing among 0+ states in even Cd isotopes. PMID- 9955024 TI - Forbidden (p,d) pickup to stretched states of 26Al. PMID- 9955028 TI - Resonating-group-method study of alpha +40Ca elastic scattering and 44Ti structure. PMID- 9955027 TI - Energy dependence of the deformed optical potential for neutron scattering from 54,56Fe and 58,60Ni up to 80 MeV. PMID- 9955029 TI - Energies and widths of states in 9B. PMID- 9955031 TI - Description of inelastic scattering between heavy ions in the Glauber model. PMID- 9955030 TI - Transfer reactions for the 50Ti + 90Zr system below the Coulomb barrier. PMID- 9955032 TI - Total projectile kinetic energy scaling in energetic nucleus-nucleus collisions. PMID- 9955033 TI - Azimuthal distributions in heavy ion collisions and the nuclear equation of state. PMID- 9955034 TI - Transitional dissipative mechanisms in the fission-like fragmentation of medium mass nuclear systems. PMID- 9955036 TI - 20F from the 13C(11B, alpha )20F reaction. PMID- 9955035 TI - 10B(7Li, 7Be)10Be charge-exchange reaction. PMID- 9955037 TI - Features of direct and sequential Coulomb breakup of 6Li ions. PMID- 9955038 TI - Influence of multiple excitation of low lying states and giant resonances on heavy ion inelastic spectra. PMID- 9955039 TI - Dispersion relation approach to sub-barrier heavy-ion fusion reactions. PMID- 9955040 TI - Ratio of spin transfer parameters dt/rt in 2H(p PMID- 9955041 TI - Elastic and inelastic scattering of 0.8 GeV protons from 20Ne and 22Ne. PMID- 9955042 TI - Excitation of the Delta resonance in the 12C(e,e') reaction. PMID- 9955043 TI - Polarization transfer for inclusive proton-nucleus inelastic scattering at 800 MeV. PMID- 9955044 TI - Nucleon-nucleon correlation effects on deeply inelastic lepton scattering in the region x>1. PMID- 9955046 TI - Low-energy K--nucleon potentials and the nature of the Lambda (1405). PMID- 9955045 TI - Exclusive quasi-deuteron absorption of pions in 16O and 18O at 116 MeV. PMID- 9955048 TI - European Muon Collaboration effect in deuteron and in three-body nuclei. PMID- 9955047 TI - One-nucleon knockout by pions and deltas. PMID- 9955049 TI - Inelastic scattering of pions by 10B. PMID- 9955050 TI - Charge symmetry breaking in neutron-proton scattering including arbitrary mesons. PMID- 9955052 TI - Elastic scattering of protons by 16O, 40Ca, and 208Pb at 200, 500, and 800 MeV: Effects of vacuum polarization and Pauli-blocking corrections. PMID- 9955051 TI - Elastic scattering of protons by 16O, 40Ca, and 208Pb at 200, 500, and 800 MeV: Relativistic and nonrelativistic analyses based on the impulse approximation. PMID- 9955053 TI - Polarization observables in pi d PMID- 9955054 TI - Polarization observables in pi d PMID- 9955055 TI - Influence of the delta-nucleon interaction on the pion-deuteron breakup process. PMID- 9955056 TI - Ground state spin and magnetic moment of 73Se. PMID- 9955057 TI - Isospin-forbidden positron decay of 48V and time-reversal invariance. PMID- 9955058 TI - 10 PMID- 9955059 TI - Elastic electromagnetic form factors of 6Li from three-body models. PMID- 9955061 TI - Problems in calculating parity ratios for nuclear level densities with the Fermi gas model. PMID- 9955060 TI - Test of a projection method from the interacting boson model-2 to the interacting boson model-1. PMID- 9955062 TI - Charge form factors and root mean square radii of 3He and 3H with the new Bonn potential. PMID- 9955063 TI - Alpha-cluster model theory of 44Ti and an effective two-body interaction. PMID- 9955064 TI - Test of the O(6) character of nuclei near A=130. PMID- 9955065 TI - Renormalizability of effective pionic Lagrangians in the nuclear medium. PMID- 9955066 TI - Microscopic investigation of the alpha +18O system in a three-cluster model. PMID- 9955068 TI - Nucleon-nucleon interaction with nonlocal tensor contribution for the 3S1-3D1 state. PMID- 9955067 TI - Ring diagram nuclear matter calculations using Bonn and V14 potentials. PMID- 9955069 TI - Limits on P- and P,T-violating absorption of MeV neutrons in 165Ho. PMID- 9955070 TI - Large-angle pi +p elastic scattering at 66.8 MeV. PMID- 9955071 TI - Decay of the first isobaric analog state in 69Ge. PMID- 9955072 TI - Yrast band in doubly-odd 138Eu. PMID- 9955073 TI - Unfavored allowed beta decay of the 11/2- isomer of 141Nd. PMID- 9955075 TI - Lepton-induced weak interactions in nuclei in the 1 to 3 GeV range. PMID- 9955074 TI - Quadrupole moment of the first 2(+) excited state in 64Zn. PMID- 9955076 TI - Quasifree electron scattering on nucleons in a momentum-dependent potential. PMID- 9955077 TI - Hermitian treatment of Dyson boson theory. PMID- 9955079 TI - Potential separable expansion approach to scattering on Coulomb-like potentials. PMID- 9955078 TI - 182-190Pt and 180-188Os isotopes in the phenomenological interacting boson model. PMID- 9955080 TI - Comment on "Model wave functions for the deuteron" PMID- 9955081 TI - Reply to "Comment on 'Model wave functions for the deuteron' " PMID- 9955082 TI - Comment on "Search for nonresonant capture in the 16O PMID- 9955083 TI - Erratum: High energy gamma rays from the 12C PMID- 9955085 TI - Usual rotational behavior in 178Os. PMID- 9955084 TI - Evidence for narrow structure in the analyzing power of the 3He(p PMID- 9955086 TI - 37Ar as a calibration source for solar neutrino detectors. PMID- 9955088 TI - beta -band moment of inertia anomaly. PMID- 9955087 TI - Reaction 6Li PMID- 9955090 TI - Spectroscopy of unbound isobaric analog states via 28Si(d,n)29P and 32S(d,n)33Cl reactions. PMID- 9955089 TI - Semidecoupling in doubly odd deformed nuclei. PMID- 9955091 TI - Vector analyzing powers for 1H(d PMID- 9955092 TI - Inelastic alpha scattering to the giant quadrupole and monopole resonances of 58Ni, 92Mo, and 120Sn at 152 MeV. PMID- 9955094 TI - One-nucleon-transfer reactions for Ag isotopes in the interacting boson-fermion model. PMID- 9955093 TI - Quadrupole transitions at very small momentum transfer in nuclei. PMID- 9955095 TI - High-energy gamma-ray production in light-ion induced reactions. PMID- 9955096 TI - Alpha-particle energy spectra from the (p, alpha ) reaction on nuclei around atomic number 50. PMID- 9955097 TI - Comparison of average s-wave resonance spacings from proton and neutron resonances. PMID- 9955099 TI - Giant monopole resonance in Sn and Sm nuclei and the compressibility of nuclear matter. PMID- 9955098 TI - 70Zn(p,t)68Zn reaction at Ep=35 MeV. PMID- 9955100 TI - Surface contributions to the complex neutron-208Pb mean field between -20 and +20 MeV. PMID- 9955101 TI - Neutron-40Ca mean field between -80 and +80 MeV from a dispersive optical-model analysis. PMID- 9955102 TI - Transport description for capture processes in nuclear collisions. PMID- 9955103 TI - Computational model for nuclear reaction studies: Quasiparticle dynamics. PMID- 9955104 TI - Sequential feeding and temperature determinations from the relative populations of widely separated states in 4He, 5Li, and 8Be nuclei. PMID- 9955105 TI - Decay of deformed 59Cu nuclei. PMID- 9955107 TI - Failure of finite-range distorted-wave Born approximation and coupled-channels Born approximation to describe (7Li,6Li) single particle transitions. PMID- 9955106 TI - Dileptons as a probe of pion, kaon, nucleon, and antinucleon dynamics in nuclear matter. PMID- 9955108 TI - Narrow component of momentum width and neutron halo in 11Li. PMID- 9955109 TI - Shape coexistence in 189Tl. PMID- 9955110 TI - Entropy from fragment yields in nucleus-nucleus collisions around 100 MeV/nucleon. PMID- 9955111 TI - Measurement of the 12C(3He, pi +)15N reaction cross section near threshold. PMID- 9955112 TI - Crossing constraints for hyperon reactions. PMID- 9955113 TI - Lambda -nucleus single-particle potentials. PMID- 9955114 TI - Isospin splitting of the giant dipole built on the isobaric analog state. PMID- 9955115 TI - Measurement of pi +d--> Delta ++n at intermediate energy. PMID- 9955116 TI - 2H(p,2p)n at 508 MeV: Recoil momenta <= 200 MeV/c. PMID- 9955118 TI - Calculation of excitation functions for proton-nucleus spallation reactions. PMID- 9955117 TI - Multiple scattering description of intermediate energy deuteron-nucleus elastic scattering. PMID- 9955120 TI - Angular distributions for 16O( gamma,p)15N at intermediate energies. PMID- 9955119 TI - Excitation function for the pion single-charge-exchange reaction 13C( pi +, pi 0)13N (g.s.). PMID- 9955121 TI - Spin observables in small-angle elastic p PMID- 9955122 TI - Neutral strange particle production and inelastic cross section in p-bar+Ta reaction at 4 GeV/c. PMID- 9955123 TI - Deep inelastic electron scattering in the distorted-wave Born approximation: An analytic approach. PMID- 9955124 TI - Laser spectroscopy of 170Tm. PMID- 9955125 TI - Double K-shell ionization accompanying internal conversion of the 0.662-MeV transition in 137Bam. PMID- 9955127 TI - Activation of 111Cdm by single pulses of intense bremsstrahlung. PMID- 9955126 TI - 43K( beta -) 43Ca and the structure of 43K and 43Ca. PMID- 9955128 TI - Fragmentation of octupole strength in even-A Pt isotopes. PMID- 9955129 TI - Shell-model predictions for electromagnetic properties of N=50 nuclei. PMID- 9955130 TI - Nuclear linear response to electroweak interactions in a relativistic theory for 16O. PMID- 9955132 TI - Interaction strengths in the interacting boson-fermion model. PMID- 9955131 TI - Linear relation between the scattering length and the size of a loosely bound two body system: One-dimensional model analysis. PMID- 9955134 TI - Comparisons between shell-model calculations, seniority truncation, and quasiparticle approximations: Application to the odd Ni isotopes and odd N=82 isotones. PMID- 9955133 TI - M3 transition to the scissors mode in the two-rotor model and random-phase approximation. PMID- 9955135 TI - Core polarization effects in sd-shell nuclei and charge-symmetry breaking in the nuclear mean field. PMID- 9955136 TI - Gyromagnetic factors of the high-spin yrast states in some doubly even germanium and selenium isotopes. PMID- 9955137 TI - Onset of large deformation and the occurrence of anomalous high-spin yrast spectra in the zirconium region. PMID- 9955138 TI - Spectral function of the p3/2 nucleons in 6Li. PMID- 9955139 TI - Nuclear spin alignment of mass separated 69Ge isomers. PMID- 9955140 TI - Possible octupole deformation in Cs and Ba nuclei from their differential radii. PMID- 9955141 TI - Scattering of charged particles in a time-dependent approach. PMID- 9955142 TI - Excitation functions for 12C+12C elastic scattering in the range Ec PMID- 9955143 TI - Finite Hermitian alternatives to the Dyson Hamiltonian. PMID- 9955145 TI - Single-particle potential in dense nuclear matter. PMID- 9955144 TI - Statistical model of subthreshold pion production. PMID- 9955146 TI - Approximations in the quasiparticle random phase evaluation of double beta decay rates. PMID- 9955147 TI - Comment on "Center-of-mass motion and Siegert's theorem" PMID- 9955148 TI - Reply to "Comment on 'Center-of-mass motion and Siegert's theorem' " PMID- 9955150 TI - Mixed symmetry in the vibrational nucleus 142Ce. PMID- 9955151 TI - Charge-radius changes in even-A platinum nuclei. PMID- 9955149 TI - Energy dependence of pion inelastic scattering to the 1(+) states in 12C. PMID- 9955152 TI - Self-consistent retardation in a three-dimensional relativistic equation. PMID- 9955153 TI - Three-body exchange mechanisms in the 3He( gamma,p)2H reaction. PMID- 9955154 TI - Energy-dependent corrections to spin observables in nucleon-nucleus inelastic scattering. PMID- 9955155 TI - Search for resonances in the 22Na(p, gamma )23Mg reaction. PMID- 9955157 TI - Breakup-fusion analyses of single-nucleon stripping to bound and unbound orbits. PMID- 9955158 TI - p-4He scattering: New data and a phase-shift analysis between 30 and 72 MeV. PMID- 9955156 TI - Inelastic electron scattering from 13C. PMID- 9955159 TI - Cross section and analyzing power measurements for the (p,d) reaction on 16O and 40Ca at 200 MeV. PMID- 9955160 TI - Detailed-balance test of time-reversal symmetry for a pair of close-lying resonances. PMID- 9955161 TI - Levels in 112Pd and 102Mo. PMID- 9955162 TI - Neutron-hole strengths and core coupling in 87Sr via the 88Sr(3He, alpha )87Sr reaction. PMID- 9955163 TI - Laser-induced two-step population of nuclear resonances near neutron binding energies. PMID- 9955164 TI - Random-phase-approximation-based dynamical polarization potential. PMID- 9955165 TI - Semiclassical description of isovector giant multipole resonances. PMID- 9955166 TI - Nucleon exchange in the absence of strong driving forces: The reaction 238U+48Ca at Elab PMID- 9955167 TI - Emission times in low-energy heavy-ion reactions by particle-particle correlations. PMID- 9955168 TI - High-spin states in 114Sn. PMID- 9955169 TI - (16O,14C) reaction on some even N=28 isotones. PMID- 9955171 TI - Symmetric collision of two slabs in the framework of the Vlasov equation. PMID- 9955170 TI - Rotational bands in 140Gd: Systematics of triaxial N=76 isotones. PMID- 9955172 TI - Nuclear liquid-gas phase transition with finite range force. PMID- 9955173 TI - Coulomb instability of hot nuclei. PMID- 9955175 TI - Antiproton and antilambda annihilations on several nucleons. PMID- 9955174 TI - Electroexcitation of the Delta resonance in the (e,e'p) reaction. PMID- 9955176 TI - Two-amplitude model for the energy dependence of double charge exchange on 18O. PMID- 9955177 TI - Nuclear charge radii of the Te isotopes from muonic atoms. PMID- 9955178 TI - Inclusive pion-nucleus double charge exchange. PMID- 9955179 TI - Internal bremsstrahlung spectrum of 35S in the range from 10 to 100 keV. PMID- 9955181 TI - Boson transition densities within the interacting-boson-model picture: Rotational limit. PMID- 9955182 TI - Relativistic quasiparticle method in nuclear physics. PMID- 9955180 TI - Decay of 149Erg+m by positron and delayed proton emission and by electron capture. PMID- 9955183 TI - 127I(3He,t)127Xe reaction with relevance to neutrino detection. PMID- 9955184 TI - Successive decays of isomers in 81Sr. PMID- 9955185 TI - Branching ratios for the 12C( gamma,p) reaction at an excitation energy of 28 MeV. PMID- 9955186 TI - Determination of the 235Th beta -decay end point energy. PMID- 9955187 TI - y scaling, binding effects, and the nucleon momentum distribution in 3He. PMID- 9955188 TI - Coarse graining of microscopic variables in the minimal information approach. PMID- 9955189 TI - Accurate energy determination of the 5673-keV state in 18F and implications in the 17O nucleosynthesis. PMID- 9955190 TI - Proton-neutron interacting boson model calculations in truncated F-spin space. PMID- 9955191 TI - Validity of F-spin multiplets and the consistent Q formalism in SU(3) nuclei. PMID- 9955193 TI - Radial shape of the Lambda N force. PMID- 9955192 TI - Self-consistent semiclassical calculation of the spin-orbit contribution to the nucleus-nucleus optical potential. PMID- 9955195 TI - Electron scattering and 14N wave functions. PMID- 9955194 TI - Comment on "Microscopic optical-potential analysis of charge-symmetry violation in pi +/- elastic scattering from 3H and 3He" PMID- 9955196 TI - Erratum: Quark distributions in nuclei PMID- 9955197 TI - Erratum: Effects of final-state interaction on the 12C(e,e'p)11B reaction PMID- 9955198 TI - Search for anomalous e+-e- annihilation from 140Pr. PMID- 9955199 TI - Irregularities at high spin in the odd-odd nucleus 158Tm. PMID- 9955200 TI - Search for the spontaneous emission of pions. PMID- 9955201 TI - Evidence for oscillating two-neutron transfer probabilities at large radial separation in heavy-ion reactions. PMID- 9955202 TI - Some relations for radiative-pion-capture and muon-capture rates. PMID- 9955204 TI - Isovector and isoscalar spin-flip excitations in even-even s-d shell nuclei excited by inelastic proton scattering. PMID- 9955203 TI - D-state effects in the radiative capture reaction d+ alpha -->6Li+ gamma. PMID- 9955205 TI - Photon scattering in the giant resonance region of 24Mg, 28Si, and 32S. PMID- 9955207 TI - Structure of the first excited state of 4He. PMID- 9955206 TI - Exact treatment of the Pauli exclusion operator in the nuclear matter Bethe Goldstone equation. PMID- 9955208 TI - Radiative proton capture to excited states in 16O. PMID- 9955209 TI - Scattering of polarized photons by protons. PMID- 9955210 TI - Evidence for M1 strength in the 3H(p PMID- 9955211 TI - Multinucleon knockout in electron scattering. PMID- 9955212 TI - Nucleon-induced deuteron breakup: Analysis of 14.1 MeV data by rigorous Faddeev calculations with meson-exchange NN interactions. PMID- 9955213 TI - Neutron-90Zr mean field from a dispersive optical model analysis. PMID- 9955214 TI - Optical model description of the neutron interaction with 116Sn and 120Sn over a wide energy range. PMID- 9955215 TI - Extrapolation of the dispersive optical model to the resonance region for neutrons on 86Kr. PMID- 9955216 TI - Nonstatistical effects observed with 52Cr+n resonances. PMID- 9955217 TI - Separable representation of the two-body Reid soft core T operator in terms of positive energy Weinberg states. PMID- 9955219 TI - Systematics of momentum distributions from reactions with relativistic ions. PMID- 9955218 TI - Preequilibrium neutron emission in the reactions 90Zr, 208Pb(p,xn) with 80 MeV projectiles. PMID- 9955220 TI - Properties of shape-driving orbitals: Rotational bands in 131La. PMID- 9955221 TI - Particle-particle coincidence measurements for 1,2,3H and 4He in the reaction 480 MeV 56Fe+natAg. PMID- 9955222 TI - Temperatures and excitation energies of hot nuclei in the reactions of 32S+Ag and 16O+Ag at 30 MeV/nucleon. PMID- 9955223 TI - Subbarrier fusion of 16O+147,149Sm. PMID- 9955224 TI - Two-neutron emission from electromagnetic dissociation of 59Co and 197Au targets by relativistic heavy ions. PMID- 9955225 TI - Rotational states in neutron-deficient 139Gd. PMID- 9955226 TI - Unique 6Li-nucleus optical potentials from elastic scattering of 210 MeV 6Li ions by 28Si, 40Ca, 90Zr, and 208Pb. PMID- 9955227 TI - Energy dependence of the optical potential for the 16O+144Sm system near the Coulomb barrier. PMID- 9955228 TI - Fragmentation mechanism in the 40Ar+58Ni reaction. PMID- 9955229 TI - Statistical calculation of fission decay probabilities of nuclear giant multipole resonances. PMID- 9955230 TI - Collective model distorted-wave Born approximation analysis of 500-MeV proton scattering from 40Ca. PMID- 9955231 TI - Lambda-neutron interaction in kaon photoproduction from the deuteron. PMID- 9955232 TI - Polarization of hypernuclei in the ( pi +,K+) reaction. PMID- 9955233 TI - Calculation of the first-order s-wave optical potential in pionic atoms. PMID- 9955235 TI - Level scheme of 148Pm and the s-process neutron density. PMID- 9955234 TI - Deuteron breakup at 2.1 and 1.25 GeV. PMID- 9955237 TI - Decay properties of 153Yb and 153Tm; Excitation energies of the s1/2 and h11/2 proton states in 153Tm. PMID- 9955236 TI - Beta decay of 30Na: Experiment and theory. PMID- 9955238 TI - Rotational perturbation to the natural-parity rotational band of 163Dy. PMID- 9955239 TI - Shape transition and dynamical symmetries in the interacting boson model. PMID- 9955240 TI - Isoscalar monopole and quadrupole strength of 16O in an alpha +12C cluster and symplectic mixed basis. PMID- 9955241 TI - Comparison of two kinds of truncations. PMID- 9955242 TI - Field theoretical model for nuclear and neutron matter: Thermal effects. PMID- 9955243 TI - Neutron-proton weak coupling: Reducing shell-model dimensions by truncations in the neutron and proton subspaces. PMID- 9955245 TI - Inverted signature dependence of B(M1) in natural-parity rotational bands. PMID- 9955244 TI - Direct measurements of neutron emission in complete and incomplete 12C-induced fusion reactions. PMID- 9955246 TI - Theoretical analysis of 208Pb(p,n) spectra at 200 MeV. PMID- 9955247 TI - Three-body forces in the SO(8) model. PMID- 9955248 TI - Use of inelastic pion scattering to study isospin mixing in nuclei. PMID- 9955249 TI - Shell-model calculations of the neutron-rich 40Cl nucleus. PMID- 9955251 TI - European Muon Collaboration effect in nuclear Drell-Yan processes. PMID- 9955250 TI - Pion charge exchange and the optical theorem. PMID- 9955252 TI - Tensor polarization in charge exchange reactions with Delta -isobar formation. PMID- 9955254 TI - Pionic components of the deuteron wave function. PMID- 9955253 TI - Nilsson parameter set in the A PMID- 9955255 TI - Density matrix expansion in the Gaussian wave-packet phase space representation. PMID- 9955256 TI - Erratum: Charge and mass distributions from the reaction of 240 MeV 12C ions with 238U PMID- 9955257 TI - Neutron decay from the giant resonance region in 208Pb. PMID- 9955258 TI - Onset of multifragment emission in heavy-ion collisions. PMID- 9955259 TI - Dependence of 12B excitation energy on its kinetic energy in the 14N + Ag reaction at E/A=35 MeV. PMID- 9955260 TI - Simple relationships in the eikonal model of the energy flow in ultrarelativistic heavy ion collisions. PMID- 9955261 TI - Absorptive effects in K+ Lambda photoproduction on nucleons and nuclei. PMID- 9955262 TI - Fragmentation of high-spin particle-hole states in 26Mg. PMID- 9955263 TI - Bonn meson-exchange potential in the N-N-bar system. PMID- 9955265 TI - Anomalous behavior in some recent parametrizations of the nucleon-nucleon S and K matrices. PMID- 9955264 TI - Structure of 14C via elastic and inelastic neutron scattering from 13C: Measurement and R-matrix analysis. PMID- 9955266 TI - Measurement of the 27Al(n, alpha )24Na reaction cross section in the energy region 7.13 to 9.01 MeV. PMID- 9955267 TI - Absolute ground-state (t,p) strengths in germanium isotopes and two-state mixing. PMID- 9955268 TI - Phenomenological analysis of dispersion corrections for neutron and proton scattering from 208Pb. PMID- 9955269 TI - Determination of 193Au and 193Hg atomic masses by the 197Au( alpha,8He)193Au reaction. PMID- 9955270 TI - Delbruck and nuclear Rayleigh effects in elastic photon scattering in the giant dipole resonance region. PMID- 9955272 TI - Statistical decay of fragments from C + 12C, 2.1 GeV/nucleon. PMID- 9955273 TI - Relativistic Vlasov-Uehling-Uhlenbeck equation for nucleus-nucleus collisions. PMID- 9955271 TI - Preequilibrium emission and target-projectile-like correlations for 20Ne+60Ni at E(20Ne PMID- 9955275 TI - 64Ni +92Zr fission yields at energies close to the Coulomb barrier. PMID- 9955276 TI - Elastic scattering of the unstable nucleus 7Be on 12C at 140 MeV. PMID- 9955274 TI - Vector polarized 6Li scattering from 12C and 16O. PMID- 9955277 TI - Classical equations-of-motion model for high-energy heavy-ion collisions. PMID- 9955278 TI - Effect of alpha -transfer polarization potential in the 24Mg PMID- 9955279 TI - Peripheral reactions induced by a 2.1-GeV/nucleon 12C beam on a C target using a simple combinatorial model. PMID- 9955280 TI - 12C+12C structure factor at sub-Coulomb energies. PMID- 9955281 TI - Rotational bands in doubly odd 176,178Re. PMID- 9955283 TI - Tunneling through equivalent multihumped fission barriers: Some implications for the actinide nuclei. PMID- 9955282 TI - Au photofission cross section by quasimonochromatic photons in the intermediate energy region. PMID- 9955285 TI - Polarization observables in pi d PMID- 9955284 TI - Kaon photoproduction from nuclei in a relativistic nuclear model. PMID- 9955286 TI - J dependence in the reaction 16O( pi +,2p)14N at 116 MeV. PMID- 9955287 TI - Neutron-proton analyzing power measurements from 375 to 775 MeV. PMID- 9955289 TI - Positron polarization from the decay of 25Al relative to 26Alm. PMID- 9955288 TI - First-order pion-nucleus optical potential in the nuclear surface near the Delta 33 resonance. PMID- 9955290 TI - Experimental mass excess of 40Cl and 42Cl. PMID- 9955291 TI - Isomers in the 123Cd and 125Cd decays and level schemes in 123In and 125In. PMID- 9955292 TI - Linear response treatment of multipole excitations at finite temperature. PMID- 9955293 TI - Resonant random phase approximation. PMID- 9955294 TI - Finite-density effective sigma meson mass in chiral models. PMID- 9955295 TI - Broken SU(3) symmetry applied to rotational nuclei: Cylindrical intrinsic states in the interacting boson model. PMID- 9955296 TI - Three- and N-body systems: An approach in terms of relative coordinates and momenta. PMID- 9955297 TI - Collective spin in nuclear dynamical symmetry. PMID- 9955299 TI - Comparison of mean-field and exact Monte Carlo solutions of a one-dimensional nuclear model. PMID- 9955298 TI - Numerical realization of the fermion dynamical symmetry model. PMID- 9955300 TI - New approach to multishell calculations in multiple angular momentum coupling schemes. PMID- 9955301 TI - Comparison of realistic and symmetry-determined S and D pairs for 156Gd. PMID- 9955302 TI - Supersymmetry classification of nuclear levels in odd-mass platinum isotopes. PMID- 9955303 TI - Structure of 17C and 17N. PMID- 9955304 TI - Importance of the neutron-proton interaction for Zr isotopes. PMID- 9955305 TI - Parametrization of the relativistic Dirac-Brueckner G matrix. PMID- 9955306 TI - Possible discontinuity in octupole behavior in the Pt-Hg region. PMID- 9955307 TI - Observation of the ground-state band of 234Th using the 232Th(18O,16O) reaction. PMID- 9955308 TI - Contributions to the E2 transition in the reaction 2H( gamma,n)p. PMID- 9955310 TI - High-energy reaction cross sections of light nuclei. PMID- 9955309 TI - Identification of 181Pb in 40Ca irradiations of 144Sm. PMID- 9955311 TI - Persistence of octupole bands to high angular momentum in the A=80 region. PMID- 9955313 TI - Finite size corrections to the thermodynamic properties of hot noninteracting fermion systems. PMID- 9955312 TI - Effective nucleon-nucleon t matrix in the (p,2p) reaction. PMID- 9955314 TI - Antisymmetrization correction for nucleon-nucleus elastic scattering. PMID- 9955315 TI - Spin of the proton and the chiral bag. PMID- 9955316 TI - Multiplicity distributions for the reaction 40Ar on 27Al calculated in the statistical multifragmentation model. PMID- 9955317 TI - Ambiguities in the determination of the elementary pn-->pn gamma bremsstrahlung cross section. PMID- 9955318 TI - alpha 4He elastic scattering at high energies. PMID- 9955319 TI - Local potential alpha -cluster model and the Wildermuth condition. PMID- 9955320 TI - Erratum: Medium energy gamma rays in nuclear reactions PMID- 9955322 TI - Alternating parity structure in doubly odd 218Ac. PMID- 9955321 TI - Zero degree cross section for the reaction 14C(p,n) 14N2.31, 14N3.95 at 200, 300, and 450 MeV. PMID- 9955324 TI - Inversion of elastic scattering phase shifts calculated with algebraic scattering theory. PMID- 9955323 TI - Nucleon exchange and heat partition in damped collisions. PMID- 9955325 TI - High spin states of even-odd Er isotopes in the interacting boson-fermion model 1. PMID- 9955326 TI - Neutral pion photoproduction on the proton near threshold and the chiral symmetry. PMID- 9955327 TI - Angular momentum dependence of the absorptive optical potential. PMID- 9955328 TI - Density dependence in the two-nucleon effective interaction at 135 MeV. PMID- 9955329 TI - Evaluation of E2 form factor: 24Mg. PMID- 9955331 TI - Nonmesonic photonuclear reactions in the three-nucleon system. PMID- 9955330 TI - 2H( gamma,n) absolute cross section at 2754 keV. PMID- 9955333 TI - Early stage equilibration dynamics in a two-component nuclear system. PMID- 9955332 TI - Low-energy nucleon-deuteron scattering. PMID- 9955334 TI - Neutron transition multipole moment for 88Sr( alpha, alpha ')88Sr (2(+), 1.84 MeV). PMID- 9955335 TI - Systematic behavior of octupole strengths in 46,48,50Ti. PMID- 9955336 TI - Thermal-neutron scattering lengths and capture by even calcium isotopes. PMID- 9955338 TI - Fission barriers of light nuclei. PMID- 9955337 TI - Heavy-ion excitation and photon decay of giant resonances in 208Pb. PMID- 9955339 TI - 12C(12C,8Be)16O cross-section measurement at sub-barrier energies. PMID- 9955340 TI - Comparison of the 13C+16O reaction with 12C+17O. PMID- 9955341 TI - Pion production and distribution in grazing relativistic heavy-ion collisions: A Monte Carlo method. PMID- 9955343 TI - Proton and neutron alignments and transition strengths in the transitional nucleus 81Rb. PMID- 9955342 TI - Systematics of charge-pickup reactions by GeV/nucleon heavy nuclei. PMID- 9955344 TI - Mass dependence of high-energy gamma-ray production in heavy-ion reactions. PMID- 9955345 TI - Quasielastic scattering of 30Si on 208Pb and the quadrupole moments of 2+ levels in 30Si. PMID- 9955346 TI - Single-particle and multiparticle analysis of nucleus-nucleus collisions at 14.6, 60, and 200 GeV/nucleon. PMID- 9955347 TI - 12C-induced single particle transfer reactions at E/A=50 MeV. PMID- 9955348 TI - Multifragmentation, fragment flow, and the nuclear equation of state. PMID- 9955349 TI - Comparison of fission of heavy nuclei induced by different probes. PMID- 9955351 TI - Production of pi degrees in the Coulomb field of nuclei by virtual photons from electron scattering. PMID- 9955350 TI - y-scaling analysis of the electromagnetic longitudinal and transverse response functions. PMID- 9955352 TI - Excitation of spin-isospin modes in the quasifree scattering region. PMID- 9955353 TI - Dirac optical potentials for nucleon scattering by 208Pb at intermediate energies. PMID- 9955354 TI - High-energy photons in neutron-proton and proton-nucleus collisions. PMID- 9955355 TI - Measurement of t20 in pi +d elastic scattering. PMID- 9955356 TI - Energy of the 32-keV transition of 83Krm and the atomic mass difference between 3H and 3He. PMID- 9955357 TI - beta + decay and cosmic-ray half-life of 54Mn. PMID- 9955358 TI - Level structure of odd-mass Pr isotopes: Decay of 3.0-min 145Ce to levels of 145Pr. PMID- 9955360 TI - Shell model study of 40S( beta -)40Cl and the energy levels of 40Cl. PMID- 9955359 TI - Decay study of 104Inm,g. PMID- 9955361 TI - Relativistic calculation of the deuteron quadrupole and magnetic moments. PMID- 9955363 TI - 9Be and 9B nuclei in a microscopic three-cluster model. PMID- 9955362 TI - Comparison between effective Hamiltonians in symmetry restoring methods: Intrinsic collective excitations in deformed nuclei. PMID- 9955364 TI - Toward a quantum chromodynamical derivation of nuclear physics. PMID- 9955365 TI - Six-fermion tests of Dyson boson mappings. PMID- 9955367 TI - Nuclear shape transitions at finite temperature. PMID- 9955366 TI - Delta component in the nuclear ground state. PMID- 9955368 TI - Nuclear structure of 154,156Dy in the dynamic pairing-plus-quadrupole model. PMID- 9955370 TI - Isovector giant dipole resonance in hot rotating light nuclei in the calcium region. PMID- 9955369 TI - Calculation of rotational spectra of well-deformed nuclei up to very high spins. PMID- 9955372 TI - Thermal-neutron cross section for 10B(n,t)2 alpha via 3He-4He mass spectrometry. PMID- 9955371 TI - Absolute photoneutron cross section of 127I. PMID- 9955374 TI - Shell-model realization of the scissors mode. PMID- 9955373 TI - Phenomenological analysis of 10B+16O elastic scattering. PMID- 9955375 TI - Intrinsic basis function in the Dyson boson mapping. PMID- 9955376 TI - Erratum: Electron scattering studies of the ground state rotational band of 152Sm PMID- 9955377 TI - Erratum: Decay of a new 16.7 min isomer of 131Sb PMID- 9955378 TI - Heavy fragment radioactivity of 238Pu: Si and Mg emission. PMID- 9955379 TI - Superdeformation in the odd-odd nucleus 150Tb: Experimental search for superdeformed configurations. PMID- 9955380 TI - 14N(n,p)14C cross section from 61 meV to 34.6 keV and its astrophysical implications. PMID- 9955381 TI - Strength function of the d5/2 hole state in 39Ca. PMID- 9955382 TI - Single-particle strength distributions in 41Ca. PMID- 9955383 TI - Heavy-fragment radioactivities and resonances in heavy-ion collisions: A correlation. PMID- 9955384 TI - Coulomb sum rule in the relativistic sigma omega rho model. PMID- 9955386 TI - Inelastic (1(+)-->0(+)) electromagnetic form factor of 6Li from three-body models. PMID- 9955385 TI - 2H(d PMID- 9955388 TI - Knockon exchange contribution in the resonating-group study of the nucleus nucleus interaction. PMID- 9955387 TI - Strong nonstatistical effects in neutron capture at the 2p size resonance region. PMID- 9955390 TI - Discretization methods of the breakup continuum in deuteron-nucleus collisions. PMID- 9955389 TI - Differential cross section at forward and backward angles for deuteron photodisintegration at intermediate energies. PMID- 9955392 TI - Microscopic optical-model calculations of neutron total cross sections and cross section differences. PMID- 9955391 TI - Parity violation in the 0.734-eV neutron resonance in 139La. PMID- 9955393 TI - Inelastic scattering of 66.5 MeV protons from 148Sm and 154Sm. PMID- 9955394 TI - 53Cr(n,n' gamma ) reactions and the level structure of 53Cr. PMID- 9955395 TI - Quasifree scattering in the preequilibrium region. PMID- 9955396 TI - Direct and preequilibrium processes studied in the 51V( alpha, alpha 'p) reaction at E alpha =172.5 MeV. PMID- 9955397 TI - Optical model analysis of polarized neutron scattering from aluminum, copper, and chromium. PMID- 9955398 TI - Optical model analysis of polarized neutron scattering from yttrium, lanthanum, and thulium. PMID- 9955399 TI - High spin states in 78Sr. PMID- 9955400 TI - Charge, mass, and energy changes during fragmentation of relativistic nuclei. PMID- 9955402 TI - Particle-core coupling in 141Pm. PMID- 9955403 TI - Relativistic dissipative hydrodynamics and the nuclear equation of state. PMID- 9955401 TI - High spin states in 137Pr. PMID- 9955405 TI - Long-range correlations in nucleus-nucleus interactions at ultrahigh energies. PMID- 9955404 TI - Neutron inclusive measurements in 14N+Ag reactions at 35 MeV/nucleon. PMID- 9955406 TI - Simultaneous analyses of elastic scattering and fusion cross sections for the 32S+58,64Ni systems at energies near the Coulomb barrier. PMID- 9955408 TI - Intermediate structure in 12C+16O system through alpha-induced reactions on 24Mg in the energy range E alpha =26-37 MeV. PMID- 9955407 TI - Nonequilibrium effects in the 139La+40Ar reaction at 10 MeV per nucleon observed in a study of neutron emission. PMID- 9955409 TI - beta -delayed fission from 256Esm and the level scheme of 256Fm. PMID- 9955410 TI - Beta-delayed fission and neutron emission calculations for the actinide cosmochronometers. PMID- 9955411 TI - Phenomenological model analysis of elastic and inelastic scattering of PMID- 9955412 TI - "Inevitable" nonstrange dibaryon. PMID- 9955414 TI - Dirac equation analysis of intermediate-energy 3He-nucleus scattering. PMID- 9955413 TI - pi - capture on the deuteron as a dibaryon search. PMID- 9955415 TI - Use of form factors in electromagnetic interactions. PMID- 9955416 TI - Approach to criticality in the fragmentation of xenon by 1-19 GeV protons. PMID- 9955417 TI - Fermi and Gamow-Teller strength in p-shell nuclei from (p,n) reactions at 492 and 590 MeV. PMID- 9955419 TI - Electromagnetic production of Sigma hypernuclei. PMID- 9955418 TI - Coupled channels analysis of positive pion inelastic scattering from 28Si at 50 MeV. PMID- 9955420 TI - Potential model calculations of parity violation in proton-proton scattering. PMID- 9955422 TI - Identification of 145Er and 145Ho. PMID- 9955423 TI - Structure of neutron-rich 74Zn from 74Cu decay and shell-model calculations for even-A Zn nuclei. PMID- 9955421 TI - Structure of odd-odd 132Sb. PMID- 9955424 TI - Beta decay of 18N to alpha particle emitting states in 18O and a proposed search for parity violation in 18O. PMID- 9955425 TI - Theory of cluster radioactive decay and of cluster formation in nuclei. PMID- 9955426 TI - Iterative boson expansion procedure for fermion systems. PMID- 9955428 TI - Mechanism of shape transition in neutron-rich palladium isotopes. PMID- 9955427 TI - Shapes and shape fluctuations in hot rotating 158Yb nuclei. PMID- 9955430 TI - Unitary transformation from color-spin to isospin-spin coupling schemes for six quark color singlet states. PMID- 9955429 TI - Isoscalar giant resonances in a relativistic model. PMID- 9955431 TI - Chiral-quark-gluon description of the nuclear force. PMID- 9955433 TI - Quark mass differences and isospin violation in the pion-nucleon coupling constants. PMID- 9955432 TI - Rotational bands and band crossings in 119Xe. PMID- 9955434 TI - Spectroscopy of 20Ne and 24Mg nuclei in the interacting boson model including g bosons. PMID- 9955436 TI - Choice of finite-temperature single-particle potential and preservation of thermodynamic relations. PMID- 9955435 TI - Macroscopic theory of heavy-ion fusion reactions. PMID- 9955438 TI - Presence of a deep inelastic component at bombarding energies close to the Coulomb barrier: The Ni+Sn case. PMID- 9955437 TI - Role of static hexadecapole deformations in subbarrier fusion reactions between heavy ions. PMID- 9955439 TI - Comment on "Electromagnetic production of kaons" PMID- 9955441 TI - Comment on "37Ar as a calibration source for solar neutrino detectors" PMID- 9955440 TI - Reply to "Comment on 'Electromagnetic production of kaons' " PMID- 9955442 TI - Reply to "Comment on '37Ar as a calibration source for solar neutrino detectors' " PMID- 9955443 TI - Comment on "Properties of intermediate width structure in 12C(12C,12C)12C (02+)" PMID- 9955445 TI - Comment on "Fusion of 32S+27Al and 19F+40Ca and the nucleus-nucleus potential" PMID- 9955444 TI - Reply to "Comment on 'Properties of intermediate width structure in 12C(12C,12C)12C (02+)' " PMID- 9955446 TI - Reply to "Comment on 'Fusion of 32S+27Al and 19F+40Ca and the nucleus-nucleus potential' " PMID- 9955447 TI - Erratum: Relativistic impulse approximation description of polarized proton elastic scattering from polarized 13C PMID- 9955448 TI - Direct ( pi +,pd) cross sections for light nuclei. PMID- 9955449 TI - Impact parameter dependence of incomplete fusion between 10 and 20 MeV/nucleon. PMID- 9955450 TI - Cluster-model calculations of exotic decays from heavy nuclei. PMID- 9955451 TI - Calculation of the absolute lifetimes of the variety of decay modes of 234U. PMID- 9955452 TI - Tests of factorization in strong-interaction few-body problems. PMID- 9955453 TI - Empirical effective interaction for 135 MeV nucleons. PMID- 9955454 TI - Neutron-induced deuteron breakup cross section at 10.3 MeV. PMID- 9955455 TI - Relativistic multipole operators for semileptonic weak and electromagnetic nuclear reactions. PMID- 9955456 TI - Coupled-channel analysis of elastic and inelastic alpha scattering on 24Mg in the energy range 28-120 MeV. PMID- 9955458 TI - Causality and the Coulomb sum rule in nuclei. PMID- 9955457 TI - Deformed nature of the 6- states in 26Al observed by the ( alpha,t) reaction. PMID- 9955460 TI - 148Gd(p,t)146Gd reaction: Neutron states in 146Gd. PMID- 9955459 TI - Convergence of the orthogonalized resonating group method. PMID- 9955461 TI - Stretched high-spin two-neutron-hole states in 206Pb and 114Sn via the (p,t) reaction at 168 MeV. PMID- 9955462 TI - Fusion of 16O + 40Ca at Elab(16O)=13.4 MeV/nucleon. PMID- 9955463 TI - Fragmentation cross sections of 28Si at 14.5 GeV/nucleon. AB - We used CR39 plastic nuclear track detectors (C12H18O7) in combination with automatic track measurement techniques to determine total charge changing and partial cross sections for the production of fragments of charge ZF = 6 to ZF = 13 in collisions of 28Si beam nuclei at 14.5 GeV/nucleon in targets H, C, CR39, (C18H38O), Al, Cu, Ag, and Pb. By application of factorization rules, measured partial cross sections are separated into pure nuclear and electromagnetic components. The cross sections for electromagnetic dissociation agree with theoretical models. The results are consistent with a Z2 dependence of virtual photon spectra. PMID- 9955464 TI - Target residues from the interaction of copper with 15-45 MeV/nucleon 12C ions. PMID- 9955466 TI - Nuclear mean field dynamics in the lattice Hamiltonian Vlasov method. PMID- 9955465 TI - g factor of the (59/2(-) isomer in 147Gd. PMID- 9955467 TI - Rotational band structure in odd-odd 132La. PMID- 9955469 TI - Systematics of fusion-fission time scales. PMID- 9955468 TI - Complete and incomplete fusion of 6 MeV/nucleon light heavy ions on 51V. PMID- 9955470 TI - Effective Lagrangian approach to K+-nucleon scattering and K+ photoproduction. PMID- 9955471 TI - Application of chiral bag model to pion photoproduction. PMID- 9955472 TI - Nuclear interaction currents. PMID- 9955473 TI - Covariant one-meson exchange in the soliton model. PMID- 9955474 TI - Electron-inclusive threshold electroproduction calculations and subthreshold kaon electroproduction from nuclei. PMID- 9955476 TI - Problems of describing spin-(3/2 baryon resonances in the effective Lagrangian theory. PMID- 9955475 TI - Isobaric yield curves at A=72 from the spallation of medium mass isotopes by intermediate energy protons. PMID- 9955477 TI - Radiative muon capture in a relativistic mean field theory: Fermi gas model. PMID- 9955478 TI - 14C( pi +, pi -)14O reaction between 19 and 80 MeV. PMID- 9955480 TI - Mechanisms for spin suppression and orbital enhancement in M1 transitions: Critical assessment. PMID- 9955479 TI - Decay of 50V. PMID- 9955481 TI - Gamma-gamma angular correlations in the decay of 76As. PMID- 9955482 TI - Collisional width of giant resonances and interplay with Landau damping. PMID- 9955483 TI - Even-odd Xe and Ba isotopes in the interacting boson-fermion model. PMID- 9955484 TI - Linear-response calculation of electromagnetic strength functions for hot, rotating nuclei. PMID- 9955485 TI - Static path approximation in deformed nuclei. PMID- 9955486 TI - Noncompact orthosymplectic supersymmetry in 61Ni and 62Ni. PMID- 9955487 TI - Random phase approximation studies in the fermion dynamical symmetry model: SO(8). PMID- 9955488 TI - Liquid-gas and superconducting phase transitions in finite symmetric nuclear matter. PMID- 9955489 TI - Heavy-fragment radioactivity of 234U. PMID- 9955490 TI - Evidence for a (semi)direct component in the decay of the isoscalar giant monopole in 208Pb. PMID- 9955491 TI - Laser-assisted internal conversion. PMID- 9955492 TI - Coupling constants in kaon photoproduction. PMID- 9955493 TI - Role of core polarization in inelastic electron scattering from even Ni isotopes. PMID- 9955494 TI - Transition from quasielastic to damped processes in the 32S+64Ni reaction. PMID- 9955496 TI - Isospin fragmentation of pairing vibrations. PMID- 9955495 TI - Renormalized quasielastic response of finite nuclei. PMID- 9955498 TI - Reply to "Comment on 'Electromagnetic dissociation of 59Co and 197Au targets by relativistic 139La projectiles' " PMID- 9955497 TI - Comment on "Electromagnetic dissociation of 59Co and 197Au targets by relativistic 139La projectiles" PMID- 9955500 TI - Erratum: Quark model calculations of nucleon structure functions PMID- 9955499 TI - Partition of excitation energy in the optimum Q-value model. PMID- 9955501 TI - Transition from quasivibrational to quasirotational structures in hot rotating 158Yb nuclei. PMID- 9955503 TI - Diffraction dissociation of photons on hydrogen. PMID- 9955502 TI - Study of quark fragmentation in e+e- annihilation at 29 GeV: Global jet parameters and single-particle distributions. PMID- 9955505 TI - Comparison of top-quark and scalar-quark production at the CERN collider. PMID- 9955504 TI - Multiplicity distribution in hadron-nucleus scattering. PMID- 9955507 TI - QCD predictions for associated production of jets in p-barp-->W+/-X. PMID- 9955506 TI - Improved perturbative QCD estimates for the hadroproduction of heavy flavors. PMID- 9955508 TI - Dissipative phenomena in quark-gluon plasmas. PMID- 9955510 TI - Measurement of the weak neutral current via nuclear parity violation. PMID- 9955509 TI - Coherent photon radiation from nuclei as a probe of impact-parameter and nucleon velocity distribution in ultrarelativistic nuclear collisions. PMID- 9955511 TI - Prompt lepton production in upsilon and t-quarkonium decays. PMID- 9955512 TI - Hadronic width of the chi 2. PMID- 9955513 TI - Detection of supersymmetric particles in W-boson decay. PMID- 9955514 TI - Phenomenological consequences of an enhanced top-quark Yukawa coupling. PMID- 9955515 TI - The S(1934). PMID- 9955516 TI - Second-order corrections to the muon anomalous magnetic moment in alternative electroweak models. PMID- 9955517 TI - Chiral model for nucleon and delta. PMID- 9955518 TI - Hyperfine splitting in a realistic basis for baryons. PMID- 9955519 TI - Quark model of light mesons with dynamically broken chiral symmetry. PMID- 9955520 TI - Semirelativistic potential model for charmonium. PMID- 9955521 TI - Gap equation for the chiral-symmetry-restoration transition. PMID- 9955522 TI - General numerical solutions of the Friedberg-Lee soliton model for ground and excited states. PMID- 9955523 TI - Precocious unification in simple grand unified theories. PMID- 9955524 TI - Lifting scalar-quark and -lepton masses with sideways U(1). II. PMID- 9955525 TI - Contribution of diffraction dissociation to the A dependence of inclusive pion fragmentation data. PMID- 9955526 TI - Completing information on a high-energy strong-interaction reaction. PMID- 9955527 TI - Chromoelectric flux tubes and the transverse-momentum distribution in high-energy nucleus-nucleus collisions. PMID- 9955528 TI - Light-meson spectra from QCD spin-dependent forces. PMID- 9955529 TI - Isospin mass splittings of hadrons with heavy quarks. PMID- 9955531 TI - Comment on radiative corrections to the decay pi 0-->e++e-+ gamma. PMID- 9955530 TI - Derivation of the Wolfenstein form of the Kobayashi-Maskawa matrix from fermion masses. PMID- 9955532 TI - Erratum: Radiative corrections to neutrino-induced neutral-current phenomena in the SU(2)L x U(1) theory PMID- 9955533 TI - Erratum: Quark-antiquark contribution to the hadroproduction of psi in the color singlet model PMID- 9955534 TI - Heavy flavors in jets from perturbative QCD. PMID- 9955535 TI - Mechanism for glueball production. PMID- 9955536 TI - Role of the equation of state in the hydrodynamical model. PMID- 9955538 TI - Symmetry behavior of the static Taub universe: Effect of curvature anisotropy. PMID- 9955537 TI - Multibaryons in Skyrme and quark models. PMID- 9955539 TI - Explicit curvature dependence of coupling constants. PMID- 9955540 TI - Proof of summed form of proper-time expansion for propagator in curved space time. PMID- 9955541 TI - Spherically symmetric systems of fields and black holes. V. Predynamical properties of causal structure. PMID- 9955542 TI - Oppenheimer-Snyder collapse with maximal time slicing and isotropic coordinates. PMID- 9955543 TI - Asymptotically Friedmann and Friedmann-type solutions to Einstein's equations when quantum effects due to conformally invariant fields are taken into account. PMID- 9955545 TI - Classification of gravitational waves in a nonsymmetric gravitational theory. PMID- 9955544 TI - Two equal Kerr-Newman sources in stationary equilibrium. PMID- 9955547 TI - Unitarity of conformal supergravity. PMID- 9955546 TI - Gravitational waves in an algebraically extended theory of gravity. PMID- 9955549 TI - Spontaneous gauge-symmetry breaking in higher-dimensional theories. PMID- 9955548 TI - N=4 remaining supersymmetry in a Kaluza-Klein monopole background in D=11 supergravity theory. PMID- 9955550 TI - Effective actions and conformal transformations. PMID- 9955551 TI - Compatibility between the Brownian metric and the kinetic metric in Nelson stochastic quantization. PMID- 9955553 TI - Bell's theorem and delayed determinism. PMID- 9955552 TI - Note on the connection between spin and statistics. PMID- 9955554 TI - Causal action at a distance in a relativistic system of two bound charged spinless particles: Hydrogenlike models. PMID- 9955555 TI - Classical relativistic constituent particles and composite states. II. PMID- 9955556 TI - On the calculation of phase shifts produced by complex potentials. II. PMID- 9955558 TI - Fractional charges for the non-Abelian fermion-monopole system. PMID- 9955557 TI - Fermions interacting with spherically symmetric monopoles: Beyond the step function approximation. PMID- 9955559 TI - Quantized electric-flux-tube solutions to Yang-Mills theory. PMID- 9955561 TI - Static solutions in the vacuum sector of the Skyrme model. PMID- 9955560 TI - The t expansion and SU(2) lattice gauge theory. PMID- 9955563 TI - Factorization of the Drell-Yan cross section in perturbation theory. PMID- 9955562 TI - Derivative expansions of fermion determinants: Anomaly-induced vertices, Goldstone-Wilczek currents, and Skyrme terms. PMID- 9955564 TI - Estimates of the electron g factor: Application of convergence acceleration methods to the QED series. PMID- 9955565 TI - Simple improvement of scaling and Lorentz invariance in lattice field theories. PMID- 9955566 TI - Lattice Skyrme model. PMID- 9955567 TI - Improved wave functions for large-N expansions. PMID- 9955568 TI - One-body approximation to the problem of three Dirac particles. PMID- 9955569 TI - Constrained superfields and gauge invariance. PMID- 9955570 TI - Note on the derivation of chiral anomalies from fermion determinants. PMID- 9955571 TI - Cancellation of higher-order anomalies. PMID- 9955572 TI - Polar gyroscopic tests of general relativity. PMID- 9955573 TI - Difficulties in synchronous-gauge density fluctuations. PMID- 9955574 TI - Special symmetries for the Utiyama Lagrangian with external Yang-Mills fields. PMID- 9955576 TI - Comment on the anharmonic oscillator and the analytic theory of continued fractions. PMID- 9955575 TI - Comment on "Simple procedure to calculate accurate energy levels of a double-well anharmonic oscillator" PMID- 9955577 TI - Renormalization-scheme-invariant perturbation theory: Miracle or mirage? PMID- 9955578 TI - Collapse of radiating fluid spheres and cosmic censorship. PMID- 9955579 TI - Reply to "Collapse of radiating fluid spheres and cosmic censorship" PMID- 9955581 TI - No-go theorems for the minimization of potentials. PMID- 9955580 TI - Erratum: Classical Kaluza-Klein cosmology for a torus space with a cosmological constant and matter PMID- 9955582 TI - Spinorial solitary wave dynamics of a (1+3)-dimensional model. PMID- 9955584 TI - Spontaneous compactification with antisymmetric tensor and scalar fields. PMID- 9955583 TI - Evidence for a first-order deconfinement transition in large-N gauge theory. PMID- 9955586 TI - Measurement of energy-energy correlations in e+e--->hadrons at sqrt s =29 GeV. PMID- 9955585 TI - Prompt muon production in e+e- annihilations at 29 GeV. PMID- 9955587 TI - New limit on the strength of mixing between nu micro and nu e. PMID- 9955588 TI - Experimental examination of the Landau-Pomeranchuk-Migdal effect by high-energy electromagnetic cascade showers in lead. PMID- 9955589 TI - Excitation rates of heavy quarks. PMID- 9955591 TI - Twist-four corrections to asymmetry in polarized-electron-deuteron scattering. PMID- 9955590 TI - Twist-four corrections to charged- and neutral-current neutrino scattering. PMID- 9955593 TI - Response of deep detectors to extraterrestrial neutrinos. PMID- 9955594 TI - Hadron-hadron interaction in a string-flip model of quark confinement. II. Nucleon-nucleon interaction. PMID- 9955592 TI - V-A structure of the charged weak current of the tau lepton and the reaction gamma +N-->1(*)+ nu 1+N' PMID- 9955595 TI - Possible stabilizing lever for the phase-shift analysis of hyperon-nucleon scattering. PMID- 9955596 TI - Experimental implications of finite-width and PT effects in W-boson radiative production. PMID- 9955598 TI - Effects of the multiple-scattering structure in the propagation of hadronic properties in nucleus-nucleus collisions. PMID- 9955597 TI - Deceleration of high-energy protons by heavy nuclei. PMID- 9955599 TI - Phenomenological coupling of excited lepton to Z0 and Z PMID- 9955600 TI - Surface vibrations of the nucleon. PMID- 9955601 TI - Baryon mass splittings and bag-model parameters. PMID- 9955603 TI - Glueball theory of the xi (2.22). PMID- 9955602 TI - Baryon spectrum of the Skyrme model. PMID- 9955605 TI - Dynamical resonances in strongly coupled Higgs models. PMID- 9955604 TI - Bounds on Higgs-boson masses in a two-doublet extension of the standard model. PMID- 9955607 TI - Nucleon electromagnetic and axial-vector form factors in the context of bag models. PMID- 9955606 TI - Recoil effects in a bag model. PMID- 9955609 TI - Surface motion of the spherical MIT bag and implications for baryon spectroscopy. PMID- 9955608 TI - Gluonic interactions in the soliton bag model. PMID- 9955610 TI - Flux-tube model for hadrons in QCD. PMID- 9955612 TI - Phenomenology on the lattice: Composite operators in lattice gauge theory. PMID- 9955611 TI - Chiral and flavor SU(2) and SU(3) symmetry breaking in quantum chromodynamics. PMID- 9955613 TI - On Z4 horizontal symmetry and left-right-symmetric theories. PMID- 9955614 TI - Nonminimal SU(5) model. PMID- 9955616 TI - N=1 supergravity theories with gravitational mass scales. PMID- 9955615 TI - Intermediate mass scale of SU(N) grand unification with nontrivial charge assignment. PMID- 9955617 TI - Light-fermion mass hierarchies in supersymmetric models. PMID- 9955618 TI - Polarization phenomena in collinear reactions. PMID- 9955620 TI - New interactions and neutrino counting. PMID- 9955619 TI - Search for micro* pi * mass enhancements in neutrino- and antineutrino-deuterium charged-current interactions. PMID- 9955621 TI - Neutrino radiative-lifetime limits from the absence of solar gamma rays. PMID- 9955622 TI - On the new value for the electron asymmetry in Sigma -->ne nu and hyperon semileptonic decays. PMID- 9955623 TI - Production of scalar-quarkonium in t-quarkonium radiative decays. PMID- 9955624 TI - Potential model for quark confinement. PMID- 9955625 TI - Measurement of K* and K0 inclusive rates in e+e- annihilation at 29 GeV. PMID- 9955626 TI - Measurement of p PMID- 9955627 TI - Role of gluon-jet fragmentation in heavy-quark production by hadrons. PMID- 9955628 TI - Deformation effects in the Skyrmion-Skyrmion interaction. PMID- 9955629 TI - Evaluation of the derivative quartic terms of the meson chiral Lagrangian from forward dispersion relations. PMID- 9955630 TI - Relics of cosmic quark condensation. PMID- 9955631 TI - Induced-gravity inflation. PMID- 9955632 TI - Gravitational radiation from cosmic strings. PMID- 9955633 TI - Detectability of certain dark-matter candidates. PMID- 9955634 TI - Gravitational Casimir energy in non-Abelian Kaluza-Klein theories. PMID- 9955635 TI - Wave function of an anisotropic universe. PMID- 9955637 TI - Gauge coupling constants of the squashed seven-sphere in eleven-dimensional supergravity. PMID- 9955636 TI - Dimension of the Universe. PMID- 9955638 TI - Einstein-Maxwell dynamics as a P(4) affine theory. PMID- 9955639 TI - Charged spinning fluids with magnetic dipole moment in the Einstein-Cartan theory. PMID- 9955640 TI - Spinor matter fields in SL(2,C) gauge theories of gravity: Lagrangian and Hamiltonian approaches. PMID- 9955641 TI - Higher-order corrections to the laws of motion and precession for black holes and other bodies. PMID- 9955642 TI - Gravitational repulsion by Kerr and Kerr-Newman black holes. PMID- 9955643 TI - Relativistic Doppler-shift effects. PMID- 9955644 TI - Einstein's gravitation as a gauge theory of the Lorentz group. PMID- 9955645 TI - Particle in an external electromagnetic field. II. The exact velocity in a constant and uniform field. PMID- 9955646 TI - Second-order wave equation for spin-(1/2) fields. PMID- 9955647 TI - Path-integral formulation of the theory of loops and strings. PMID- 9955648 TI - Multiple-turning-point problems and lattice multiscale singular perturbation. PMID- 9955649 TI - Scalar field theory in 3+1 dimensions. PMID- 9955650 TI - Class of solutions of Yang's R-gauge equations and self-duality. PMID- 9955651 TI - Nonlocal Hamiltonian gauge theories and their connection with lattice Hamiltonians. PMID- 9955652 TI - Quantization of a nonlocal Abelian gauge theory and certain local-limit implications. PMID- 9955653 TI - Exact ground-state properties of the SU(2) Hamiltonian lattice gauge theory. PMID- 9955654 TI - Chiral order parameter of the Wilson fermion formulation in a lattice CPN-1 model. PMID- 9955655 TI - Gauge invariance, charge conservation, and axial anomaly in fermion-monopole interactions. PMID- 9955656 TI - Axial and parity anomalies and vacuum charge: A direct approach. PMID- 9955657 TI - Chiral anomaly, bosonization, and fractional charge. PMID- 9955658 TI - Nambu-Jona-Lasinio-type effective Lagrangian: Anomalies and nonlinear Lagrangian of low-energy, large-N QCD. PMID- 9955659 TI - Chiral-symmetry breaking in supersymmetric gauge theories. PMID- 9955660 TI - Supersymmetric models for quarks and leptons with nonlinearly realized E PMID- 9955661 TI - Self-energy corrections to fermions in the presence of a thermal background. PMID- 9955662 TI - Localization of the dyon charge. PMID- 9955663 TI - Exact gravitational field of a string. PMID- 9955664 TI - Calculating heat kernels. PMID- 9955665 TI - Connections between the soliton dynamics provided by some integrable relativistic theories. PMID- 9955666 TI - N=1 supersymmetric Yang-Mills theory in the light-cone gauge. PMID- 9955667 TI - Fractionization of the Witten index in some soluble models. PMID- 9955668 TI - Interaction of electric and magnetic charges: Addendum. PMID- 9955669 TI - Crossover from strong to weak coupling in lattice gauge theory with dynamical fermions. PMID- 9955670 TI - Thermodynamics of SU(2) gauge theory with dynamical, light fermions. PMID- 9955672 TI - Gravitational collapse of a radiating shell of matter. PMID- 9955671 TI - Nicolai maps on manifolds. PMID- 9955674 TI - Multisoliton solutions to Einstein's equations. PMID- 9955673 TI - Strong-coupling quantum gravity. III. Quasiclassical approximation. PMID- 9955675 TI - Anisotropic Kaluza-Klein cosmologies. PMID- 9955676 TI - Geometry of Kaluza-Klein theory. I. Basic setting. PMID- 9955677 TI - Geometry of Kaluza-Klein theory. II. Field equations. PMID- 9955678 TI - Does a phase transition in the early universe produce the conditions needed for inflation? PMID- 9955679 TI - Constraints on stress-energy perturbations in general relativity. PMID- 9955681 TI - Nonminimal N=1 supergravity effective theories. PMID- 9955680 TI - Stability of charged rotating black holes in the eikonal approximation. PMID- 9955683 TI - Quantum radiation in a one-dimensional cavity with moving boundaries. PMID- 9955682 TI - Harmonic expansions for (4+K)-dimensional Rarita-Schwinger fields on coset spaces and effective Lagrangian in four dimensions. PMID- 9955684 TI - World-line condition and the noninteraction theorem. PMID- 9955685 TI - One-dimensional motion for classical relativistic two-body systems in time asymmetric Lorentz scalar potentials. PMID- 9955686 TI - Radiative corrections to classical particle motion in a magnetic field. PMID- 9955687 TI - Unitary transformations of photon polarization vectors. PMID- 9955688 TI - Axial-gauge formulation of a three-dimensional field theory. PMID- 9955690 TI - Chiral anomaly and the Wess-Zumino condition. PMID- 9955689 TI - Supersymmetric QED at finite temperature and the principle of equivalence. PMID- 9955692 TI - Variational estimates for spectra in lattice Hamiltonian theories. PMID- 9955691 TI - Symmetry breaking of SU(n) gauge theories to maximal regular subgroups and fourth rank tensors. PMID- 9955693 TI - SU(N) x SU(N) chiral models on asymmetric lattices with standard and improved actions. PMID- 9955695 TI - Non-Abelian magnetic flux at high temperatures. PMID- 9955694 TI - Gauge invariance and the finite-element solution of the Schwinger model. PMID- 9955696 TI - Construction of a new class of axially symmetric SU(N) monopole solutions by Neugebauer's dressing method. PMID- 9955697 TI - QCD vacuum as a chromomagnetic superconductor: Microscopic physics. PMID- 9955698 TI - QCD chiral-symmetry breaking in a Rayleigh-Ritz variational calculation. PMID- 9955699 TI - Radiating Vaidya metric imbedded in de Sitter space. PMID- 9955700 TI - Superstring cosmology. PMID- 9955702 TI - Majorana spinors in higher-dimensional theories. PMID- 9955701 TI - Gravitational coupling of neutrinos to matter vorticity. II. Microscopic asymmetries in angular momentum modes. PMID- 9955704 TI - Tilde substitution law in thermo field dynamics: Thermal state conditions. PMID- 9955703 TI - Central two-particle forces are not sufficient in relativistic Newtonian mechanics for particles with spin. PMID- 9955706 TI - Reducing the number of flavors in the microcanonical method. PMID- 9955707 TI - Critical behavior of doubling approximations of the : phi4:2 lattice field theories. PMID- 9955705 TI - Comparison of the canonical Hamiltonian and the Hamiltonian of Callan and Rubakov for the monopole-fermion system. PMID- 9955709 TI - Causal fields and spin-statistics connection for massless particles in higher dimensions. PMID- 9955708 TI - Erratum: Modified quantum chromodynamics and ultraviolet divergences PMID- 9955710 TI - Search for heavy charged particles and light nuclei and antinuclei produced by 400-GeV protons. PMID- 9955712 TI - Monte Carlo study of colorless clusters in jets. PMID- 9955711 TI - Effects of heavy unconventional scalars in leptonic interactions. PMID- 9955713 TI - Diquark cascade and meson production in diquark-deuteron fragmentation. PMID- 9955715 TI - Multiparticle production in proton-nucleus collisions at 200 GeV. PMID- 9955714 TI - Inclusive psi hadroproduction from quark-gluon scattering. PMID- 9955716 TI - Proton-nucleus inclusive reactions and momentum degradation of quarks. PMID- 9955717 TI - Angular distribution of shower particles produced in the collisions of 30-400-GeV protons with emulsion nuclei. PMID- 9955718 TI - Testing supersymmetry interpretations of anomalous missing-pT events observed at the CERN pp-bar collider. PMID- 9955719 TI - Angular distributions in anomalous l+l- gamma events. PMID- 9955720 TI - Photon and dilepton emission from the quark-gluon plasma: Some general considerations. PMID- 9955721 TI - Ultrahigh-energy cosmic-ray spectrum. PMID- 9955722 TI - Properties of gluino-gluino-gluon states. PMID- 9955724 TI - Limitations of a semiclassical treatment of the Skyrme soliton. PMID- 9955723 TI - Chiral-symmetry breaking and light-quark masses in lattice QCD. PMID- 9955725 TI - New methods for static meson potentials. PMID- 9955726 TI - Tree-unitarity constraints on supersymmetric theories. PMID- 9955727 TI - Quark clusters and the deep-inelastic structure functions of nuclei. PMID- 9955728 TI - Light gauge fermions and scalar-electron pair production in e+e- annihilation. PMID- 9955729 TI - Weak Delta S=1 scattering experiments: Are they needed and feasible? PMID- 9955730 TI - Spin effects in large-angle meson-baryon scattering. PMID- 9955732 TI - On the polarization of the sea quarks. PMID- 9955731 TI - Phenomenological approach to secondary-particle yields in ultrarelativistic nuclear interactions. PMID- 9955733 TI - Compositeness signature of Z0 in the ll-bar gamma decay mode. PMID- 9955734 TI - KL--> gamma gamma in supersymmetric gauge theory. PMID- 9955735 TI - Electromagnetic mass splittings of heavier hadrons in the MIT bag model. PMID- 9955736 TI - Ground-state pseudoscalar nonet and the generalized MIT bag model. PMID- 9955737 TI - Rotational-vibrational coupling in the Skyrme-soliton model for baryons. PMID- 9955738 TI - Two-loop Feynman-gauge calculation of the meson nonsinglet evolution potential. PMID- 9955739 TI - Grand unification and supergravity in SO(10). PMID- 9955740 TI - Gauge-boson bound states in a unified SO14 model. PMID- 9955741 TI - Erratum: Models for polarization asymmetry in inclusive hadron production PMID- 9955742 TI - Hadronic invariant mass in semileptonic top decay: A simple way to detect top particle decay? PMID- 9955743 TI - Production of charged Higgs particles in W* decay. PMID- 9955745 TI - Kaluza-Klein cosmologies and inflation. II. PMID- 9955744 TI - Structure of elastic p-p scattering at low and high energies. PMID- 9955746 TI - Decaying particles do not "heat up" the Universe. PMID- 9955748 TI - Evolution equation for the Higgs field in an expanding universe. PMID- 9955747 TI - Feynman rules for finite-temperature Green's functions in an expanding universe. PMID- 9955749 TI - Scalar electrodynamics in Robertson-Walker universes. PMID- 9955750 TI - Quantum instability of de Sitter spacetime. PMID- 9955752 TI - Generic instabilities in first-order dissipative relativistic fluid theories. PMID- 9955751 TI - Inflation and reheating in Bianchi type-IX cosmology. PMID- 9955753 TI - Nonstatic radiating spheres in general relativity. PMID- 9955754 TI - Weak and strong quantum vacua in Bianchi type-I universes. PMID- 9955755 TI - Particle creation in de Sitter space. PMID- 9955756 TI - Particle and energy creation by moving mirrors. PMID- 9955757 TI - Black hole in thermal equilibrium with a scalar field: The back-reaction. PMID- 9955758 TI - Spherically symmetric systems of fields and black holes. IV. No room for black hole evaporation in the reduced configuration space? PMID- 9955759 TI - Relativistic transformation law of quantum fields: A slight generalization consistent with the equivalence of all Lorentz frames. PMID- 9955760 TI - Yang-Mills equations and parallel propagation on closed paths. PMID- 9955761 TI - Nonperturbative many-body techniques applied to a Yang-Mills field theory. PMID- 9955762 TI - Fermions and stochastic quantization. PMID- 9955763 TI - Schwinger-DeWitt proper-time expansion and eikonal approximation. PMID- 9955765 TI - New lattice approximation of gauge theories. PMID- 9955764 TI - Galilean-invariant gauge theory. PMID- 9955766 TI - Improved Hamiltonian variational technique for lattice models. PMID- 9955767 TI - Improved projector Monte Carlo study of string tension and roughening in lattice QED in three dimensions. PMID- 9955768 TI - Finite-temperature deconfinement and chiral-symmetry restoration at strong coupling. PMID- 9955769 TI - Nonperturbative effects in equilibrium finite-temperature scalar field theory. PMID- 9955770 TI - Locally supersymmetric SU(6) grand unified theory without fine-tuning and strong CP problems. PMID- 9955771 TI - Preon dynamics and the supersymmetric extension of local current algebra. PMID- 9955772 TI - Color confinement and the quantum-chromodynamic vacuum. II. Gluon propagation and the Coulomb interaction. PMID- 9955773 TI - Contribution of light quarks to the deconfinement transition in QCD. PMID- 9955774 TI - Odd-soliton solutions of the Einstein equations in a vacuum. PMID- 9955775 TI - Higher-dimensional extensions of Bianchi type-I cosmologies. PMID- 9955776 TI - Limitations of constraint dynamics. PMID- 9955777 TI - General calculation of the N=4 supersymmetric Yang-Mills self-energy in an effective light-cone gauge formalism. PMID- 9955778 TI - Nonlinear motion of a classical string: The Nambu string. PMID- 9955779 TI - Solitary waves in the Nambu-Jona-Lasinio Lagrangian. PMID- 9955781 TI - High-density behavior in supersymmetry. PMID- 9955780 TI - Mean-plaquette analysis of the SU(3) lattice gauge theory. PMID- 9955782 TI - Asymptotic behavior of quark masses induced by instantons. PMID- 9955783 TI - Erratum: Finite-temperature and supercharged ideal supersymmetric matter PMID- 9955784 TI - New form for the coincidence limit of the Feynman propagator, or heat kernel, in curved spacetime. PMID- 9955785 TI - Production of the K-bar PMID- 9955787 TI - Rapidity and charge correlations of centrally produced charged particles in events with a high-momentum pi 0 near 11 degrees. PMID- 9955786 TI - Transverse-spin dependence of the p-p total cross section Delta sigma T from 0.8 to 2.5 GeV/c. PMID- 9955788 TI - Measurement of the dijet cross section in 400-GeV/c pp interactions. PMID- 9955790 TI - Change of confinement scale in nuclei: Predictions for structure functions confront electroproduction data. PMID- 9955789 TI - Study of Bose-Einstein correlations in e+e- annihilation at 29 GeV. PMID- 9955792 TI - QCD scaling violations for spin-dependent structure functions. PMID- 9955791 TI - Variations of the confinement scale for quarks in nuclei. PMID- 9955794 TI - S-wave meson-nucleon scattering in an SU(3) cloudy bag model. PMID- 9955793 TI - Triple hadronic-energy correlations in high-energy e-e+ annihilation. PMID- 9955795 TI - Geometrical scaling in high-energy hadron collisions. PMID- 9955796 TI - Quarkonium production at pp-bar colliders. PMID- 9955797 TI - Phenomenological Lagrangian for nonleptonic charmed-meson decays. PMID- 9955799 TI - Fits to the hadron masses in the chiral bag model. PMID- 9955798 TI - Calculation of exclusive decay modes of the tau. PMID- 9955800 TI - Confined Coulombic model for heavy-light-quark systems. PMID- 9955801 TI - Characteristic size for the neutrino. PMID- 9955802 TI - Anomalous magnetic moment of light quarks and dynamical symmetry breaking. PMID- 9955803 TI - Chiral Lagrangian of pseudoscalars and vectors. PMID- 9955804 TI - Periodic Skyrme solitons. PMID- 9955806 TI - Supersymmetric unified compositeness and the quark-lepton generation structure. PMID- 9955805 TI - Chiral fermions beyond the standard model. PMID- 9955807 TI - Charge distributions of hadrons associated with hadronic J/ psi production. PMID- 9955809 TI - Flavor-changing decays of the Z0 and supersymmetry. PMID- 9955808 TI - Crossing versus noncrossing quark-line diagrams in p-barp-->two mesons. PMID- 9955811 TI - Quintet baryon model for hadron interactions. PMID- 9955810 TI - Fixing the Higgs-boson mass. PMID- 9955812 TI - Resonant-exchange mechanism: Limitations to its effectiveness. PMID- 9955814 TI - Rapidity signatures of phase transition in high-energy nucleus-nucleus collisions. PMID- 9955813 TI - Parity nonconservation in proton-water scattering at 1.5 GeV/c. PMID- 9955815 TI - F-meson production rate in bottom-meson decays. PMID- 9955816 TI - Is there another set of left-handed W and Z bosons? PMID- 9955817 TI - Quantum cosmology with a positive-definite action. PMID- 9955818 TI - Cosmologies with quasiregular singularities. I. Spacetimes and test waves. PMID- 9955819 TI - Cosmologies with quasiregular singularities. II. Stability considerations. PMID- 9955820 TI - Cosmology with decaying particles. PMID- 9955821 TI - Realization of new inflation. PMID- 9955822 TI - Global-symmetry evolution in axion cosmologies. PMID- 9955823 TI - Test-particle motion in Einstein's unified field theory. I. General theory and application to neutral test particles. PMID- 9955824 TI - Test-particle motion in Einstein's unified field theory. II. Charged test particles. PMID- 9955825 TI - Maximally slicing a black hole with minimal distortion. PMID- 9955827 TI - Gravitation without black holes. PMID- 9955826 TI - Stimulated emission and black holes. PMID- 9955829 TI - Gravitational versus finite-temperature effects in SU(5) symmetry breaking. PMID- 9955828 TI - Four forces and spinor connection in general relativity. PMID- 9955831 TI - Fractional fermion number in Kaluza-Klein theories. PMID- 9955830 TI - Field-theoretical model for nuclear and neutron matter. I. Equation of state. PMID- 9955832 TI - Matrix general relativity and Yang-Mills theory. PMID- 9955834 TI - Quantum mechanics as a classical theory. PMID- 9955833 TI - Forced harmonic oscillator with damping and thermal effects. PMID- 9955835 TI - Functional-integral approach to Parisi-Wu stochastic quantization: Abelian gauge theory. PMID- 9955836 TI - Canonical formalism on a null surface: The scalar and the electromagnetic fields. PMID- 9955838 TI - lambda phi4 theory in the nonrelativistic limit. PMID- 9955837 TI - Boundary effects and the massless limit of the photon. PMID- 9955839 TI - Chiral anomalies and zeta-function regularization. PMID- 9955840 TI - Covariant generalization of the Zitterbewegung of the electron and its SO(4,2) and SO(3,2) internal algebras. PMID- 9955841 TI - Self-consistent phases in topological particle theory. PMID- 9955842 TI - Derivation of discrete invariances (T,C, and P) and the connection between spin and statistics in topological particle theory. PMID- 9955843 TI - Percolation temperature and the "instability" of the effective potential. PMID- 9955845 TI - Strong CP problem and flat potential. PMID- 9955844 TI - Probing kink interactions with fermions. PMID- 9955846 TI - Axial anomaly in three dimensions and planar fermions. PMID- 9955847 TI - Dimensional phase transitions: Coupling of matter to the cell complex. PMID- 9955848 TI - Hamiltonian Monte Carlo calculation in two-dimensional SU(2) QCD with fermions. PMID- 9955849 TI - Chiral-symmetry restoration transition in the presence of dynamical quarks. PMID- 9955850 TI - Gaussian corrections around the mean-field approximation for the mixed SU(2) lattice gauge theory. PMID- 9955851 TI - Renormalization flow of SU(3) lattice gauge actions. PMID- 9955852 TI - Using maximally symmetric lattices to improve scaling and Lorentz invariance in the O(3) nonlinear sigma model. PMID- 9955853 TI - Levinson theorem for Dirac particles. PMID- 9955855 TI - Physical conceptualization of the gravitational vacuum field equations. PMID- 9955854 TI - Quadratic Lagrangian for general relativity theory. PMID- 9955856 TI - Note on Kaluza-Klein theories. PMID- 9955857 TI - Free energy in thermo field dynamics. PMID- 9955858 TI - Fractional fermion number and its thermal effect. PMID- 9955859 TI - Path-integral solution for a two-dimensional model with axial-vector-current pseudoscalar derivative interaction. PMID- 9955860 TI - Loop equations and constraints in two-dimensional QCD. PMID- 9955861 TI - Chiral anomaly in the Schwinger-Symanzik formalism. PMID- 9955862 TI - Gluon propagator and transverse vertices. PMID- 9955863 TI - Topological invariance of the Witten index and related quantities. PMID- 9955864 TI - Are there higher topological obstructions relevant to unified theories? PMID- 9955865 TI - Lattice thermodynamics for gauge theories. PMID- 9955866 TI - U(1) lattice-gauge-Higgs theory with radial degrees of freedom. PMID- 9955867 TI - Multiple-time observables in quantum theory. PMID- 9955868 TI - Reply to the comment of Cohen and Peres. PMID- 9955869 TI - Erratum: Mass-derivative formula and the singularity structure in thermo field dynamics PMID- 9955870 TI - Dynamical quark mass at finite temperature. PMID- 9955871 TI - Precision measurement of the total cross section for e+e--->hadrons at a center of-mass energy of 29 GeV. PMID- 9955873 TI - Valons in mesons. PMID- 9955872 TI - Primary-cosmic-ray energy spectrum up to 50 TeV derived from sea-level muon measurements. PMID- 9955874 TI - Production of composite neutral Higgs bosons in photoproduction and e+e- experiments. PMID- 9955875 TI - Amplitude description of elastic pp scattering at 800 MeV. PMID- 9955876 TI - Search for supersymmetric particles in hadron-hadron collisions. PMID- 9955877 TI - Asymmetry effects of supersymmetric QCD in dilepton production. PMID- 9955878 TI - Proton decay and Higgs particles in SU(5). PMID- 9955879 TI - Simple dynamical hadron mass-spectrum calculations incorporating hadronic channels arising from qq-bar creation. PMID- 9955880 TI - Static properties of the nucleon octet in a relativistic potential model with center-of-mass correction. PMID- 9955881 TI - Supersymmetric electromagnetic moments and radiation zeros. PMID- 9955882 TI - Consequences of the improved Kobayashi-Maskawa matrix for mixing and CP nonconservation in K0-K-bar 0 and B0-B-bar 0 systems. PMID- 9955883 TI - Constraints on the mixing of a fourth family of quarks. PMID- 9955884 TI - Breaking of isospin symmetry in theories with a dynamical Higgs mechanism. PMID- 9955885 TI - Linearly rising Regge trajectories and bag and string models for hadrons. PMID- 9955886 TI - Hadron structure in a simple model of quark/nuclear matter. PMID- 9955887 TI - Center-of-mass corrections and fermions consisting of confined quarks. PMID- 9955888 TI - Intermediate mass scales in the new SO(10) grand unification in the one-loop approximation. PMID- 9955890 TI - Composite invisible axion. PMID- 9955889 TI - Experimental tests of new SO(10) grand unification. PMID- 9955891 TI - Production of gluinos in gamma gamma collisions. PMID- 9955893 TI - gamma p-->F+F-p reaction as a possible test for 0(++) glueball state. PMID- 9955892 TI - Polarized e+e- collisions as a tool to reveal supersymmetric particles. PMID- 9955895 TI - W gamma production in pp collisions and the magnetic moment of the W boson. PMID- 9955894 TI - Verification of NN( 3P0) structure predicted by isobar coupling. PMID- 9955897 TI - Analysis of the decay psi -->vector PMID- 9955896 TI - Remark on an SU(3)f-violating decay of the psi. PMID- 9955898 TI - Primary electron spectrum in semileptonic B decays. PMID- 9955900 TI - t-quarkonium predictions from an interquark potential with relativistic corrections. PMID- 9955899 TI - Testing the single-quark radiation hypothesis. PMID- 9955901 TI - Finite-size effects on bag thermodynamics. PMID- 9955902 TI - Scaling in lattice QCD with Kogut-Susskind fermions. PMID- 9955903 TI - Origin of structure in the Universe. PMID- 9955904 TI - Large-scale energy-density perturbations and inflation. PMID- 9955905 TI - Quantum mechanics of inflation. PMID- 9955906 TI - Physical approach to cosmological homogeneity. PMID- 9955907 TI - Anisotropy and cosmic nucleosynthesis of light isotopes including 7Li. PMID- 9955908 TI - Laws of motion and precession for black holes and other bodies. PMID- 9955909 TI - Inhomogeneous electromagnetic gravitational collapse. PMID- 9955911 TI - Charged spin fluid in the Einstein-Cartan theory. PMID- 9955910 TI - Bargmann structures and Newton-Cartan theory. PMID- 9955912 TI - Gravitational models of a Lorentz extended electron. PMID- 9955913 TI - Adiabatic exponents and equations of state for neutron-star matter. PMID- 9955914 TI - Glory scattering by black holes. PMID- 9955916 TI - Stability of Englert-type solutions on Npqr spaces in d=11 supergravity. PMID- 9955915 TI - Space-time: Arena or illusion? PMID- 9955917 TI - Time variation of coupling constants in Kaluza-Klein cosmologies. PMID- 9955918 TI - Stability of ten-dimensional Kaluza-Klein supergravity. PMID- 9955919 TI - Magnetic monopoles from antisymmetric tensor gauge fields. PMID- 9955920 TI - Monopole annihilation and causality. PMID- 9955921 TI - Restoration of spontaneously broken continuous symmetries in de Sitter spacetime. PMID- 9955923 TI - 1/c expansion of a separable model of direct-interaction type. PMID- 9955922 TI - Statistical mechanics in a covariant gauge. PMID- 9955925 TI - Properties of a classical charged harmonic oscillator accelerated through classical electromagnetic zero-point radiation. PMID- 9955924 TI - Matter and radiation in equilibrium. PMID- 9955926 TI - Path-wise stochastic calculus of variations with the classical action and quantum systems. PMID- 9955927 TI - Baker-Campbell-Hausdorff relations and unitarity of SU(2) and SU(1,1) squeeze operators. PMID- 9955928 TI - Super lattices and gauge theory. PMID- 9955929 TI - Axial anomaly and the ac Josephson effect in (1+1)-dimensional models. PMID- 9955930 TI - Yang-Mills theories in the light-cone gauge. PMID- 9955931 TI - Explicit Hamiltonian for SU(2) lattice gauge theory. PMID- 9955932 TI - Interactions between quark clusters in lattice QCD. PMID- 9955933 TI - Abelian and non-Abelian bosonization in the path-integral framework. PMID- 9955934 TI - Memory-function approach to retardation effects in the relativistic two-body problem. PMID- 9955936 TI - Fractional charge and spectral asymmetry in one dimension: A closer look. PMID- 9955935 TI - Zitterbewegung of the electron in external fields. PMID- 9955937 TI - Radiative corrections in supersymmetric gauge theories. PMID- 9955938 TI - Hadronic contributions to the anomalous magnetic moment of the muon. PMID- 9955939 TI - Differential cross section of electron-positron bremsstrahlung. PMID- 9955940 TI - Repulsive gravitation and electron models. PMID- 9955941 TI - Homogeneous, nonsingular, closed Einstein-Cartan cosmological model. PMID- 9955942 TI - Rotational anomalies without anyons. PMID- 9955943 TI - Radiatively induced topological mass terms in (2+1)-dimensional gauge theories. PMID- 9955945 TI - Gauge covariance of the effective potential. PMID- 9955944 TI - Explicit decoupling gauge condition. PMID- 9955946 TI - New Lagrangian formalism for the bag. PMID- 9955947 TI - Nonperturbative analysis of leading logarithms in three-dimensional QED. PMID- 9955948 TI - Thermal production of superheavy magnetic monopoles in the new inflationary universe scenario. PMID- 9955951 TI - Sensing-area distribution functions for one- and three-loop superconductive magnetic-monopole detectors. PMID- 9955952 TI - Exotic processes in high-energy e-p collisions. PMID- 9955950 TI - Limits on deeply penetrating particles in the >10(17) eV cosmic-ray flux. PMID- 9955949 TI - Inclusive hadron production in upsilon decays and in nonresonant electron positron annihilation at 10.49 GeV. PMID- 9955953 TI - Long-range effects in the weak parity-violating pion-nucleon coupling. PMID- 9955954 TI - K+-proton partial-wave analysis to 3 GeV/c. PMID- 9955956 TI - Diffraction dissociation and the Chou-Yang model. PMID- 9955955 TI - KN scattering in the cloudy bag model: s, p, and d waves. PMID- 9955957 TI - Kl3+ decays involving finite neutrino mass and mass mixing. PMID- 9955958 TI - Long- and short-distance contributions to kaon decays. PMID- 9955959 TI - SU(3) breaking in K-->K gamma from QCD sum rules. PMID- 9955960 TI - Hadron-hadron interaction in a string-flip model of quark confinement. I. Meson meson interaction. PMID- 9955961 TI - Majorana neutrino masses and lepton mixing angles in the perturbative and semiempirical approach. PMID- 9955962 TI - Numerical solutions to an extended chiral bag model. PMID- 9955963 TI - Quantum relativistic oscillator. Modifying the Hamiltonian formalism of the relativistic string. PMID- 9955965 TI - Monopole-induced baryon-number violation in "realistic" grand unified theories. PMID- 9955964 TI - Symmetry breaking in SO(10): Higgs-boson structure. PMID- 9955966 TI - Dynamical symmetry breaking and composite model for leptons, quarks, and Higgs mesons. PMID- 9955968 TI - Implications for logarithmic-singularity contribution to e+e---> pi + pi - gamma reaction at Q2=0.9 GeV2 from bremsstrahlung background. PMID- 9955967 TI - New results on the reaction e+e---> micro+ micro- at sqrt s =29 GeV. PMID- 9955969 TI - Striking pattern of a strong-interaction reaction. PMID- 9955970 TI - Two-body decays of K mesons in a microscopic framework. PMID- 9955972 TI - Excited Z0 bosons and the anomalous CERN events. PMID- 9955971 TI - Radiative decay of heavy Higgs bosons. PMID- 9955974 TI - High-spin mesons in the quark model. PMID- 9955973 TI - Comparison of beam-dump and vector-boson-decay production of new neutral heavy leptons. PMID- 9955975 TI - Interesting four-quark states besides xi (2220). PMID- 9955976 TI - Symmetrical parametrization of the Kobayashi-Maskawa matrix. PMID- 9955977 TI - Bound on the horizontal coupling from a deviation from universality. PMID- 9955978 TI - Erratum: Ratio of lifetimes for the D+ and D0 mesons PMID- 9955980 TI - Limits on excited spin-3/2 leptons. PMID- 9955981 TI - Charged-hyperon production by 400-GeV protons. PMID- 9955979 TI - Observation of the decay B-bar 0-->D PMID- 9955982 TI - Negative-kaon and antiproton production near 700 MeV/c by 28.4-GeV/c protons. PMID- 9955983 TI - Measurement of the reaction pi +n PMID- 9955984 TI - Energy distribution of leptons from e+e--->W+W- PMID- 9955985 TI - Looking for weak-boson compositeness via form factors. PMID- 9955987 TI - Systematics of pi N scattering in chiral soliton models. PMID- 9955986 TI - Intermediate-mass Higgs-boson production in polarized e+e- colliders. PMID- 9955988 TI - Amplitudes of the two-nucleon interaction at 579 MeV. PMID- 9955990 TI - Nonstandard Higgs bosons as a source of monojets. PMID- 9955989 TI - Testing spinless-boson-parent models for anomalous l+l- gamma events. PMID- 9955992 TI - Nucleon-nucleus reactions at ultrarelativistic energies. PMID- 9955991 TI - Triple-Regge phenomenology. A new approach. PMID- 9955993 TI - Stability of detonation fronts leading to quark-gluon plasma. PMID- 9955994 TI - Another mode of decay of M micro pi (0.429). PMID- 9955995 TI - Possibility of searching for Higgs boson in t-quarkonium decays. PMID- 9955996 TI - Lorentz noninvariance and the Eotvos experiments. PMID- 9955997 TI - Gauge invariance of the KL-KS mass difference in left-right-symmetric models. PMID- 9955998 TI - Gauge-invariant calculation of the KL-KS mass difference in the left-right model. PMID- 9955999 TI - Mesons in a relativized quark model with chromodynamics. PMID- 9956000 TI - Hyperfine splitting of quarkonium. PMID- 9956001 TI - Mixing of tt-bar bound states with the Z boson. PMID- 9956002 TI - Magnetic moments of heavy quarks and leptons. PMID- 9956003 TI - Neutrino mass matrix. PMID- 9956004 TI - Anomalous, chiral Lagrangians of pseudoscalar, vector, and axial-vector mesons generated from quark loops. PMID- 9956005 TI - Conjecture concerning the modes of excitation of the quark-gluon plasma. PMID- 9956007 TI - Nonrenormalization of phases, softly broken Peccei-Quinn symmetry, and strong-CP problem. PMID- 9956006 TI - Unique chiral three-preon model of quarks and leptons. PMID- 9956008 TI - Searching for scalar-quarkonium at proton-antiproton colliders. PMID- 9956009 TI - Interpreting p-p polarization at high energies. PMID- 9956010 TI - Lepton-flavor-violating decays of Z0 and tau. PMID- 9956011 TI - In search of Q2Q-bar2 mesons in J/ psi radiative decays. PMID- 9956013 TI - Electric dipole moment of the deuteron. PMID- 9956012 TI - Tensor particles A2(1320), f(1270), and f'(1525) and the decay rate of K1--> gamma gamma. PMID- 9956014 TI - Charge-commutation-relation approach to composite vector bosons in SU(2)L/rU(1)Y. The case with W and Z. PMID- 9956016 TI - Mixing of a heavy neutrino with the electron neutrino. PMID- 9956015 TI - Can supersymmetry particles fake the top-quark signal? PMID- 9956017 TI - Path-integral quantum cosmology. I. Vacuum Bianchi type I. PMID- 9956018 TI - Path-integral quantum cosmology. II. Bianchi type I with volume-dependent source. PMID- 9956020 TI - Will entropy decrease if the Universe recollapses? PMID- 9956019 TI - Arrow of time in cosmology. PMID- 9956021 TI - Wave packet in quantum cosmology. PMID- 9956022 TI - Classical and quantum cosmology of the Starobinsky inflationary model. PMID- 9956023 TI - Expansion isotropization during the inflationary era. PMID- 9956024 TI - Quantum effect on Kaluza-Klein cosmologies: High-temperature case. PMID- 9956025 TI - Functional measure in Kaluza-Klein theories. PMID- 9956027 TI - Gravitational radiation and the validity of the far-zone quadrupole formula in the Newtonian limit of general relativity. PMID- 9956026 TI - Stationary axisymmetric post-Minkowskian metrics. PMID- 9956028 TI - Point-particle limit and the far-zone quadrupole formula in general relativity. PMID- 9956029 TI - Parametrized-post-Newtonian limit of the scalar-tetradic theory A. PMID- 9956031 TI - Monopole abundance in the Solar System and the intrinsic heat in the Jovian planets. PMID- 9956030 TI - Gravitational counterterms and Becchi-Rouet-Stora symmetry. PMID- 9956032 TI - Symmetry breaking via compensators in an N=1 supergravity theory. PMID- 9956033 TI - Alternative extension of supersymmetry. PMID- 9956034 TI - Gauge-invariant statistical mechanics and average action principle for the Klein Gordon particle in geometric quantum mechanics. PMID- 9956036 TI - Supersymmetry and the relationship between the Coulomb and oscillator problems in arbitrary dimensions. PMID- 9956035 TI - Quantum-mechanical evolution of generalized coherent states and semiclassical approximation. PMID- 9956037 TI - Classical paths for a dissipative quantum system. PMID- 9956038 TI - Determination of binding energy in field theory using a basis wave-functional expansion. PMID- 9956040 TI - Quantum field theory on discrete space-time. II. PMID- 9956039 TI - Functional approach to derivative expansion of the effective Lagrangian. PMID- 9956041 TI - Solution of the light-cone equation for the relativistic bound state. PMID- 9956043 TI - Single-surface basis for topological particle theory. PMID- 9956042 TI - Conformal invariance and gauge fixing in QED. PMID- 9956045 TI - Ambiguity structure of the full VVA-triangle graph in 4 and n dimensions. PMID- 9956044 TI - Phases of higher-order terms in the topological expansion. PMID- 9956046 TI - Conformal invariance and string theory in compact space: Bosons. PMID- 9956047 TI - Gauge-boson composites. PMID- 9956048 TI - Variational method for field theories on the lattice and the spectrum of the phi4 theory in 1+1 dimensions. PMID- 9956049 TI - Langevin simulations of lattice field theories. PMID- 9956050 TI - Self-consistent field approximation for string tension in SU(2) lattice gauge theory. PMID- 9956051 TI - Microcanonical formulation of lattice gauge theories with fermions. PMID- 9956053 TI - Renormalization flow on a lattice and deconfinement. PMID- 9956052 TI - Properties of phase transitions of the lattice SU(2) Higgs model. PMID- 9956054 TI - Gauge fixing the SU(N) lattice-gauge-field Hamiltonian. PMID- 9956055 TI - Prolongation structure, Lie-Backlund vector fields, and conservation laws for Yang-Mills theory in two dimensions. PMID- 9956057 TI - Thermodynamics of two-dimensional QCD in the large-N limit. PMID- 9956056 TI - Variational approach to (2+1)-dimensional QED. PMID- 9956058 TI - Dynamical hadronization transition and hydrodynamical stability. PMID- 9956059 TI - Cosmological constraints on heavy unstable particles. PMID- 9956060 TI - Quantum relativistic oscillator. III. Contraction between the algebras of SO(3,2) and the three-dimensional harmonic oscillator. PMID- 9956062 TI - Relation between global and U1 anomalies. PMID- 9956061 TI - Thermal averages in covariant gauges. PMID- 9956064 TI - Bifurcation of the type-II solutions of the Yang-Mills equations with static sources. PMID- 9956063 TI - Adiabatic expansion and higher-order corrections for induced currents. PMID- 9956066 TI - Anomalous interactions for the supersymmetric nonlinear sigma model in two dimensions. PMID- 9956065 TI - Semiclassical approach to Dirac operators in external gauge fields corresponding to supersymmetric quantum systems. PMID- 9956067 TI - Erratum: Forced harmonic oscillator with damping and thermal effects PMID- 9956068 TI - Searches for unstable neutral leptons in low-multiplicity events from electron positron annihilation. PMID- 9956070 TI - J/ psi decays into a vector and a pseudoscalar meson and the quark content of the eta and eta ' PMID- 9956069 TI - Inclusive photoproduction of strange baryons at 20 GeV. PMID- 9956072 TI - Measurement of D0 lifetime in e+e- annihilation at high energy. PMID- 9956073 TI - Study of the radiative decay K+--> micro+ nu gamma. PMID- 9956071 TI - Measurement of the decay Upsilon (2S)--> pi pi Upsilon (1S). PMID- 9956074 TI - Final polarizations in quasielastic neutrino-nucleon scattering. PMID- 9956075 TI - Supersymmetric effects in polarized-e*-p scattering. PMID- 9956076 TI - Koba-Nielsen-Olesen-scaling violations in the dual parton model. PMID- 9956077 TI - QCD background for the UA1 W-->tb-bar signal. PMID- 9956078 TI - Jets in W and Z production from QCD showers. PMID- 9956079 TI - Pre-equilibrium emission of lepton pairs from oscillating quark-antiquark plasma. PMID- 9956080 TI - Model-independent analysis of hadronic decays of J/ psi and eta c(2980). PMID- 9956081 TI - Scalar mesons and the decay of the iota: A paradox explained. PMID- 9956082 TI - Matter-antimatter oscillations and proton decay in E6. PMID- 9956083 TI - Exclusive heavy-meson production in Z0 decay. PMID- 9956084 TI - Detection rates for "invisible"-axion searches. PMID- 9956085 TI - New observable phases in a supersymmetric extension of the standard model. PMID- 9956086 TI - Baryon self-energy due to the pion-quark interaction. PMID- 9956087 TI - Restrictions on two-Higgs-doublet models from heavy-quark systems. PMID- 9956088 TI - Symmetry-breaking patterns in left-right-symmetric models: How to ensure natural flavor conservation and a soft CP violation. PMID- 9956089 TI - Internal states in the pion static model. PMID- 9956090 TI - Generation of grand unification hierarchies due to supergravity. PMID- 9956092 TI - Photoproduction of a neutrino pair from an electron and astrophysical implications of neutrino-emission processes. PMID- 9956091 TI - Another look at Z-->ll-bar gamma decay. PMID- 9956093 TI - b-barbx and W--> nu tau backgrounds for the UA1 monojet signal. PMID- 9956094 TI - How to describe weak-interaction mixing and maximal CP violation? PMID- 9956096 TI - Derivation of mass relations for composite W and Z from effective-Lagrangian approach. PMID- 9956095 TI - On parametrizing the N-generation quark mixing matrix. PMID- 9956097 TI - Measurement of the analyzing power for p+p PMID- 9956098 TI - Stellar energy loss through scalar-neutrino production. PMID- 9956100 TI - Bianchi type-I model with cosmological constant in a generalized scalar-tensor theory of gravitation. PMID- 9956099 TI - Experimental tests of the gravitational inverse-square law for mass separations from 2 to 105 cm. PMID- 9956102 TI - Aspects of quasi-Riemannian Kaluza-Klein theory. PMID- 9956101 TI - General numerical solution of cylindrical gravitational waves. PMID- 9956103 TI - Three-dimensional closed universes without collapse in a five-dimensional Kaluza Klein theory. PMID- 9956104 TI - Quantum particle production in an expanding universe and Kaluza-Klein theories. PMID- 9956105 TI - Godel cosmology in Riemann-Cartan spacetime with spin density. PMID- 9956106 TI - Regular reduction of relativistic theories of gravitation with a quadratic Lagrangian. PMID- 9956107 TI - Vacuum states in de Sitter space. PMID- 9956108 TI - Vacuum polarization of the electromagnetic field near a rotating black hole. PMID- 9956109 TI - Gravitational counterterms in an axial gauge. PMID- 9956110 TI - Goldstone bosons in string models of galaxy formation. PMID- 9956111 TI - "Isothermal" density perturbations in an axion-dominated inflationary universe. PMID- 9956112 TI - Supersymmetric formulation of gravity theories with nontrivial Lorentz connection. PMID- 9956114 TI - Stability analysis of Einstein/Maxwell-scalar system. PMID- 9956113 TI - Gauged seven-dimensional N=2 pure supergravity with two-form potential and its compactifications. PMID- 9956115 TI - Low-energy limit of strings. PMID- 9956116 TI - Analysis of a quantum measurement. PMID- 9956118 TI - Finite-dimensional approximation of time evolution operators: A nonperturbative approach to quantum field theories. PMID- 9956117 TI - Massless fields of arbitrary spin, uniformly accelerated frames, and the zero point energy. PMID- 9956119 TI - Constraints on Hamiltonian lattice formulations of field theories in an expanding universe. PMID- 9956120 TI - Periodic solutions of the mixed nonlinear Schrodinger equation. PMID- 9956121 TI - Gauge-invariant description of massive higher-spin particles by dimensional reduction. PMID- 9956123 TI - Is there a solution to the Rarita-Schwinger wave equation in the presence of an external electromagnetic field? PMID- 9956122 TI - Quadratic divergences in dimensional renormalization of 1/N expansions. PMID- 9956124 TI - Strings at finite temperature. PMID- 9956125 TI - Cosmological heavy-neutrino problem. PMID- 9956126 TI - Vacuum charge: Another study in 1+1 dimensions. PMID- 9956127 TI - Asymptotic scaling in Hamiltonian calculations of the O(3) sigma model. PMID- 9956128 TI - Meson electric form factor on the lattice. PMID- 9956130 TI - Orthogonal and unitary matrices in arbitrary dimensions. PMID- 9956129 TI - Compact solitons, bags, and radial excitations. PMID- 9956131 TI - Anomalies, dimensional regularization, and the heat kernel. PMID- 9956132 TI - Minimum amount of inflation to solve the flatness and horizon problems. PMID- 9956133 TI - Brans-Dicke-type models with torsion. PMID- 9956134 TI - Isometries of homogeneous Godel-type spacetimes. PMID- 9956135 TI - Nonrelativistic potential scattering through the shifted large-dimension expansion. PMID- 9956137 TI - Statistical systems in higher dimensions. PMID- 9956136 TI - Generalized Klein-Gordon equations in d dimensions from supersymmetry. PMID- 9956138 TI - Monte Carlo study of the axial-gauge gluon propagators on the Polyakov-Wilson lattice. PMID- 9956139 TI - Expansion of single-link integrals around a saddle-point configuration. PMID- 9956140 TI - Comments on the Born approximation in Aharonov-Bohm Scattering. PMID- 9956142 TI - Massive generalization of the Weinberg potential for a free photon. PMID- 9956141 TI - A rule for the combinatoric factors of Feynman diagrams. PMID- 9956144 TI - Effect of the axion halo on bound electrons. PMID- 9956143 TI - Erratum: Two-body Dirac equation for semirelativistic quarks PMID- 9956145 TI - Dipole gravitational radiation in the nonsymmetric gravitational theory of Moffat. PMID- 9956146 TI - Experimental test of the law of gravitation. PMID- 9956148 TI - Several theorems about the interference of particle beams and the theoretical interpretation of Collela-Overhauser-Werner and Marton experiments. PMID- 9956147 TI - Continuous observations in quantum mechanics: An application to gravitational wave detectors. PMID- 9956149 TI - Stability of Schwarzschild black holes in fourth-order gravity. PMID- 9956150 TI - Mass spectrum of chiral ten-dimensional N=2 supergravity on S5. PMID- 9956151 TI - Generalized coherent states and generalized squeezed coherent states. PMID- 9956153 TI - Radiative corrections in grand unified theories based on N=1 supergravity. II. Gauge theories. PMID- 9956152 TI - Dynamics of gauge systems and Dirac's conjecture. PMID- 9956154 TI - Field theories in replica formalism and fixed points. PMID- 9956155 TI - Bose-Fermi correspondence and Kac-Moody algebras in four dimensions. PMID- 9956156 TI - Renormalization of Yang-Mills theory in the Abelian gauge. PMID- 9956157 TI - Natural gauge without any ghost for Yang-Mills theory. PMID- 9956158 TI - Dimensional reduction and theories with massive gauge fields. PMID- 9956159 TI - Gauging of Dirac-Kahler fermions on the cubic lattice. PMID- 9956160 TI - Effects of dynamical quark loops on Monte Carlo simulation in lattice gauge theory. PMID- 9956162 TI - Color confinement and the quantum-chromodynamic vacuum. III. PMID- 9956161 TI - Anomalies, Levinson's theorem, and fermion determinants. PMID- 9956163 TI - Abelian model for mesons. PMID- 9956164 TI - From Regge trajectories to a static sine-Gordon-type equation. PMID- 9956166 TI - Cosmological perturbations in a universe dominated by a coherent scalar field. PMID- 9956165 TI - Derivation of a formula in finite-temperature field theory. PMID- 9956167 TI - Gravitational Aharonov-Bohm effect in three dimensions. PMID- 9956168 TI - Anomaly cancellations and compactifications in the SO(32) superstring theory. PMID- 9956169 TI - Topological degree for supersymmetric chiral models. PMID- 9956170 TI - Chiral Jacobians and two-dimensional QED at finite temperature. PMID- 9956171 TI - Derivation of the Lee-Yang term via stochastic quantization. PMID- 9956172 TI - Chemical potential on the lattice. PMID- 9956173 TI - New two-step approach to one-dimensional anharmonic oscillators. PMID- 9956174 TI - Opposite-sign dilepton production in nu micro interactions. PMID- 9956176 TI - Measurement of the rate for pion beta decay. PMID- 9956175 TI - Search for heavy long-lived particles in high-energy cosmic rays. PMID- 9956178 TI - Description of the energy dependence of proton-proton partial-wave amplitudes by means of O(4) expansions. PMID- 9956179 TI - Energy dependence of the valon-valon matter form factor. PMID- 9956177 TI - Decays of the J/ psi into two pseudoscalar mesons. PMID- 9956180 TI - Monte Carlo studies of high-transverse-energy hadronic interactions. PMID- 9956181 TI - Gluino contributions to high-transverse-momentum hadron production at very high energies. PMID- 9956182 TI - Psi production through three-gluon fusion. PMID- 9956183 TI - Nuclear stopping power at high energies. PMID- 9956184 TI - Thermalization of quarks and gluons in heavy-ion collisions. PMID- 9956186 TI - Some dynamical properties of the pion in pi +-->e+ nu gamma and pi +-->e+e+e- nu decays. PMID- 9956185 TI - Supersymmetric-particle production at pp-bar collider energies. PMID- 9956188 TI - Nonleptonic kaon decay. PMID- 9956187 TI - Calculation of the width of the decay psi '--> psi eta. PMID- 9956190 TI - Hyperon radiative decay. PMID- 9956189 TI - Fourth-generation charged leptons and neutrinos via Z0. PMID- 9956191 TI - Higgs-boson decays at the superconducting super collider. PMID- 9956193 TI - Lepton distributions from the decay of scalar-lepton pairs at e+e- colliders. PMID- 9956192 TI - Lepton distributions from the decay of W-tilde pairs at e+e- colliders. PMID- 9956194 TI - Apparatus-dependent contributions to g-2? PMID- 9956195 TI - Hadronic contributions to the g-2 of the muon. PMID- 9956196 TI - Study of light baryons in the three-quark-cluster model: Exact calculations. PMID- 9956197 TI - Bound states of heavy Q2Q-bar 2 systems. PMID- 9956198 TI - Couplings of low-lying glueballs to photons and to heavy quarks. PMID- 9956200 TI - Quark confinement in quantum chromodynamics. PMID- 9956199 TI - Exotic fermions. PMID- 9956202 TI - Quantum relativistic oscillator. II. Nonrelativistic limit and phenomenological justification. PMID- 9956201 TI - Helicity amplitudes and Regge behavior for simple planar hadron amplitudes. PMID- 9956204 TI - Cryogenic photon-mass experiment. PMID- 9956205 TI - Multijet events with missing transverse momentum from scalar-quark pair production at the CERN pp-bar collider. PMID- 9956203 TI - Improved upper limit on nu tau mass. PMID- 9956207 TI - Multipole moments of (composite) W's and the magnetic moment of the muon. PMID- 9956206 TI - D decays: Do theory and experiment agree? PMID- 9956208 TI - Mass of the H dibaryon in a chiral model. PMID- 9956209 TI - qq-bar pair creation: A field-theory approach. PMID- 9956210 TI - Comment on bag models with spontaneously broken color symmetry. PMID- 9956211 TI - Quantum chromodynamics with colored Higgs mechanism. PMID- 9956212 TI - Damping mechanisms for coherent oscillations of axions. PMID- 9956214 TI - Membrane viewpoint on black holes: Dynamical electromagnetic fields near the horizon. PMID- 9956213 TI - Quantitative analysis of the thermal damping of coherent axion oscillations. PMID- 9956215 TI - Three-dimensional conformal supergravity and Chern-Simons terms. PMID- 9956216 TI - Further investigations of the Kerr-de Sitter space. PMID- 9956217 TI - Classical limit of the Korteweg-de Vries hierarchy of isospectral transformations. PMID- 9956218 TI - Dirac equation in a six-dimensional spacetime: Temporal polarization for subluminal interactions. PMID- 9956219 TI - Classical spin and its quantization. PMID- 9956220 TI - Zero-point field in curved spaces. PMID- 9956221 TI - Radiation from initially static vacuum structures. PMID- 9956222 TI - Impossibility of supersymmetry restoration in quantum-mechanical systems. PMID- 9956223 TI - Temperature corrections in the case of derivative interactions. PMID- 9956224 TI - Color confinement, Becchi-Rouet-Stora symmetry, and negative dimensions. PMID- 9956225 TI - Factorization of soft and collinear divergences in QCD in the Feynman gauge via a background field gauge. PMID- 9956226 TI - Nonperturbative propagators in quantum chromodynamics. PMID- 9956227 TI - One-loop vacuum polarization in the nonlinear R xi gauge. PMID- 9956228 TI - Internal symmetries of non-Abelian gauge field configurations. PMID- 9956229 TI - New stochastic algorithm and its application to compact QED. PMID- 9956230 TI - Gauge Potts model with generalized action: A Monte Carlo analysis. PMID- 9956231 TI - Self-duality for eight-dimensional gauge theories. PMID- 9956232 TI - Manifestly covariant, Poincare-invariant quantum theories of directly interacting particles. PMID- 9956233 TI - Mean-plaquette approximation for lattice gauge theories at finite temperature. PMID- 9956234 TI - Path-integral derivation of the heat kernel on SU(N) space. PMID- 9956235 TI - Higher-dimensional Einstein-Maxwell theory with inflation. PMID- 9956236 TI - Does the return flux result in the Aharonov-Bohm scattering amplitude? PMID- 9956237 TI - Three-dimensional O(N) model with Fermi and scalar fields. PMID- 9956238 TI - Radiative corrections to the topological mass in (2+1)-dimensional electrodynamics. PMID- 9956239 TI - Invariants of self-adjoint rank-four SU(n) tensors. PMID- 9956240 TI - 1/N corrections in the matrix model and the quantum collective field. PMID- 9956241 TI - Dispersive derivation of the triangle anomaly. PMID- 9956243 TI - New type of two-photon squeezed coherent states. PMID- 9956242 TI - Remarks on scalar solitons and the virial constraint. PMID- 9956244 TI - Finite-temperature effects on the energy levels of hydrogenlike atoms. PMID- 9956245 TI - Comment on "How to make quantum mechanics look like a hidden-variable theory and vice versa" PMID- 9956246 TI - Reply to "Comment on 'How to make quantum mechanics look like a hidden-variable theory and vice versa' " PMID- 9956248 TI - Topology of four-dimensional lattice gauge fields. PMID- 9956247 TI - Weak-coupling universality in SU(3) mixed actions: Theory versus high-statistics simulation. PMID- 9956249 TI - Study of D production in high-energy gamma p interactions. PMID- 9956251 TI - Nuclear effects in deep-inelastic lepton scattering. PMID- 9956250 TI - Triggered-bubble-chamber study of the reaction pi +p--> Delta ++ pi 0 pi 0 at 16 GeV/c. PMID- 9956252 TI - Pion-nucleon partial-wave analysis to 1100 MeV. PMID- 9956253 TI - Estimates of hadronic production of DD-bar from dilepton mass spectrum in fusion model. PMID- 9956254 TI - Diagnosing quark matter by measuring the total entropy and the photon or dilepton emission rates. PMID- 9956255 TI - Single-electron/muon signature for heavy leptons and W gauginos at the CERN pp bar collider. PMID- 9956256 TI - Standard-model dimuon sources in pp-bar collisions. PMID- 9956257 TI - Direct photon production by positive- and negative-pion beams. PMID- 9956259 TI - Reanalysis of Higgs-boson-exchange models of CP violation. PMID- 9956258 TI - Production and detection of high-energy neutrinos from Cygnus X-3. PMID- 9956261 TI - Weak D-->K pi decays revisited. PMID- 9956260 TI - QCD corrections to the decay B--> psi X. PMID- 9956262 TI - Proton decay cannot be suppressed kinematically. PMID- 9956263 TI - Mass dependence of searches for fractional charge in matter using ion-beam techniques. PMID- 9956264 TI - Experimental consequences of a heavy neutral fermion. PMID- 9956265 TI - Coupling charmonium to the charmed-meson sector. PMID- 9956266 TI - Self-consistent meson coupling calculations. PMID- 9956267 TI - Fermion mass hierarchy as a consequence of the spontaneous breakdown of the four flavor symmetry. PMID- 9956268 TI - 1/N expansion (N=number of generations) and mass hierarchy of charged fermions in composite model for leptons, quarks, and Higgs mesons. PMID- 9956269 TI - Supersymmetry and electron + missing pT+ jet events. PMID- 9956270 TI - Distinguishing between Dirac and Majorana neutrinos in neutrino-electron scattering. PMID- 9956271 TI - Double-beta-decay suppression with three generations of Majorana neutrinos. PMID- 9956272 TI - Muons in gamma showers from Cygnus X-3? PMID- 9956273 TI - On a mechanism for small neutrino masses. PMID- 9956274 TI - Composite-W-boson couplings. PMID- 9956275 TI - Additional scalar bosons in SU(5) theories. PMID- 9956276 TI - Behavior of relativistic wave functions near the origin for a QCD potential. PMID- 9956277 TI - Erratum: Exotic processes in high-energy e-p collisions PMID- 9956278 TI - Direct photon production in e+e- collisions. PMID- 9956279 TI - On the electromagnetic properties of Majorana fermions. PMID- 9956280 TI - Evaporation of strange matter in the early Universe. PMID- 9956281 TI - Numerical analysis of inflation. PMID- 9956282 TI - Quantum cosmological model of the inflationary universe. PMID- 9956283 TI - Effects of quantum fields on singularities and particle horizons in the early universe. III. The conformally coupled massive scalar field. PMID- 9956284 TI - Power-law inflation. PMID- 9956285 TI - General relativistic strings. PMID- 9956286 TI - Cosmological compactification. PMID- 9956287 TI - Black-hole bubbles. PMID- 9956288 TI - Field equations and spontaneous compactification in quasi-Riemannian theories of gravity. PMID- 9956289 TI - Yang-Mills-Einstein supergravity in seven dimensions. PMID- 9956290 TI - Massive fluid spheres in general relativity. PMID- 9956291 TI - Curvature tensor for Kaluza-Klein theories with homogeneous fibers. PMID- 9956292 TI - Spin distributions for a spheroidal Cartan fluid. PMID- 9956294 TI - Stochastic formulations of the Maxwell field in the temporal gauge. PMID- 9956293 TI - Realistic physical origin of the quantum observable operator algebra in the frame of the causal stochastic interpretation of quantum mechanics: The relativistic spin-zero case. PMID- 9956295 TI - Gaussian effective potential. II. lambda phi4 field theory. PMID- 9956296 TI - Renormalization group and nonlocal terms in the curved-spacetime effective action: Weak-field results. PMID- 9956297 TI - Renormalization of the coupled cluster equations in three-dimensional phi4 quantum field theory. PMID- 9956298 TI - Coupled cluster description of field theories: Procedures and their application to the vacuum sector in (1+1)-dimensional Phi 4 field theories. PMID- 9956299 TI - New canonical structures in Liouville theories and strings without tachyons in D<25. PMID- 9956301 TI - Dipole mechanism of spontaneous breaking of N=2 supersymmetry. II. Reformulation and generalization in harmonic superspace. PMID- 9956300 TI - Effect of the radiation component on soliton motion. PMID- 9956303 TI - Simple approach to tunneling using the method of finite elements. PMID- 9956302 TI - Discrete-time quantum mechanics. PMID- 9956304 TI - Analysis of spin and gauge models with variational methods. PMID- 9956305 TI - Fast algorithm for Monte Carlo simulations of systems with fermions. PMID- 9956306 TI - Dynamical structure of the quantum relativistic rotator and analogy to Rohrlich's version of the quantum relativistic string. PMID- 9956307 TI - One-potential quantum field theory of spinless charges and monopoles: General formalism and the infrared problem. PMID- 9956308 TI - Boson subalgebras and classification of boson state vectors. PMID- 9956309 TI - Evolution equation and relativistic bound-state wave functions for scalar-field models in four and six dimensions. PMID- 9956311 TI - Large-N gauge theory of loops and strings. I. PMID- 9956310 TI - Stable SU(5) monopoles with higher magnetic charge. PMID- 9956312 TI - Large-N gauge theory of loops and strings. II. PMID- 9956313 TI - Structure of axionic domain walls. PMID- 9956314 TI - Parameter counting for self-dual monopoles. PMID- 9956315 TI - Fermion-monopole system reexamined. III. PMID- 9956316 TI - Isotropization and homogenization of an anisotropic and inhomogeneous cosmological model during the inflationary era. PMID- 9956317 TI - New derivation of Lopez's source of the Kerr-Newman field. PMID- 9956319 TI - Erratum: Canonical quantization of supergravity PMID- 9956318 TI - Angular momentum and wave functions in monopole and related potentials. PMID- 9956320 TI - Erratum: Differential cross section of electron-positron bremsstrahlung PMID- 9956322 TI - Question of degenerate states in supersymmetric quantum mechanics. PMID- 9956321 TI - Kaluza-Klein mixmaster universes. PMID- 9956323 TI - Intranuclear cascade in nu microNe interactions. PMID- 9956324 TI - Measurements of triple- and double-spin parameters in elastic p-p scattering at 6 GeV/c. PMID- 9956325 TI - Evidence for time and directional enhancements of multimuon cosmic-ray events. PMID- 9956326 TI - Higgs bosons from vector-boson fusion in e+e-, ep, and pp collisions. PMID- 9956327 TI - On the observability of B0-B-bar0 mixing in the e+e--->BB-barX reaction at sqrt s PMID- 9956328 TI - Excited fermions and low-energy parity-violating phenomena. PMID- 9956329 TI - Meson-exchange models for low-energy nucleon-antinucleon scattering. PMID- 9956330 TI - Nucleon-antinucleon annihilation via confined quark-gluon states. PMID- 9956331 TI - Quark-gluon model for diffraction at high energies. PMID- 9956332 TI - Geometrical model of multiparticle production in hadron-hadron collisions. PMID- 9956333 TI - Role of the QCD-induced gluon-gluon coupling to gauge-boson pairs in the multi TeV region. PMID- 9956334 TI - Transverse-momentum distribution of produced particles in ultrarelativistic nucleus-nucleus collisions. PMID- 9956335 TI - Evidence for stabilized strange-quark matter in cosmic rays? PMID- 9956336 TI - K2 pi decays. PMID- 9956337 TI - Weak electric and magnetic form factors for semileptonic baryon decays in an independent-quark model. PMID- 9956339 TI - Mixtures of quarkonium and gluonium. PMID- 9956340 TI - Pseudoscalar electromagnetic vertex function: Quark-hadron duality. PMID- 9956338 TI - Nonleptonic decays of chiral solitons and a possible resolution of the S-wave/P wave puzzle. PMID- 9956342 TI - Muon capture in a general class of weak models. PMID- 9956341 TI - (V+A) components from the measured observables in muon capture. PMID- 9956344 TI - Constraints on the Higgs-boson masses in left-right electroweak gauge theories. PMID- 9956343 TI - Radiative annihilation of K-p atoms and the Lambda (1405). PMID- 9956345 TI - Extended strongly interacting Higgs theories. PMID- 9956346 TI - Renormalization of the axial-vector current in QCD. PMID- 9956347 TI - An effective Lagrangian for quantum chromodynamics: The structure of hadrons. PMID- 9956348 TI - Numerical solution of soliton bag models. PMID- 9956349 TI - Sudden change in the bulk properties of nucleon-antinucleon plasma at a certain temperature in the relativistic Hartree approximations. PMID- 9956350 TI - Dynamical axion. PMID- 9956351 TI - A rare decay of the D PMID- 9956352 TI - Elusive "penguin" mechanism for K decay. PMID- 9956353 TI - Rephasing invariant formulation of CP violation in the Kobayashi-Maskawa framework. PMID- 9956354 TI - Radiative decay of quarkonium into Higgs scalar. PMID- 9956356 TI - Erratum: Parity and signature determination by the V1V2 decay mode PMID- 9956355 TI - Center-of-mass correction and confinement radii of the composite vector bosons. PMID- 9956358 TI - Interior solutions for rotating fluid spheres. PMID- 9956357 TI - Majorana neutrinos and photinos from kaon decay. PMID- 9956359 TI - Absence of super-radiance of the Dirac particles in the Kerr-Newman geometry and the weak positive-energy condition. PMID- 9956360 TI - Relativistic radiation transport in dispersive media. PMID- 9956361 TI - Wigner transformation in curved space-time and the curvature correction of the Vlasov equation for semiclassical gravitating systems. PMID- 9956363 TI - Quantum mechanics of the scalar field in the new inflationary universe. PMID- 9956362 TI - Semiclassical wave function of the Universe at small three-geometries. PMID- 9956365 TI - Creation-field cosmology: A possible solution to singularity, horizon, and flatness problems. PMID- 9956364 TI - Stability of self-consistent higher-dimensional cosmological solutions. PMID- 9956366 TI - Entropy production due to gravitational-wave viscosity in a Kaluza-Klein inflationary universe. PMID- 9956367 TI - Quantum states and the Hadamard form. III. Constraints in cosmological space times. PMID- 9956368 TI - Scalar field theories in curved space. PMID- 9956369 TI - Superfield perturbation theory in harmonic superspace. PMID- 9956370 TI - Quantum measurements of finite duration. PMID- 9956371 TI - Multiple-time properties of quantum-mechanical systems. PMID- 9956372 TI - Pseudoclassical description of a relativistic spinning particle. PMID- 9956373 TI - Solving field theory in one space and one time dimension. PMID- 9956374 TI - Discretized light-cone quantization: Solution to a field theory in one space and one time dimension. PMID- 9956375 TI - Soliton sector of the ( phi4)2 quantum field theory in the Hartree approximation. PMID- 9956377 TI - Current-definition freedom in a derivative-coupling model. PMID- 9956376 TI - Equations of minimal manifolds. PMID- 9956378 TI - Gauge invariance for spin-3 fields. PMID- 9956379 TI - Charge of the vacuum in (1+1)-dimensional fermion theories with external fields. II. Zero energy gap. PMID- 9956380 TI - Quantum corrections to false vacuum decay in the Coleman-Weinberg potential. PMID- 9956382 TI - Monte Carlo study of the Abelian Higgs model. PMID- 9956381 TI - Quantum roll: A study of the long-time behavior of the finite-element method. PMID- 9956384 TI - Nonperturbative study of hadronization with heavy sources: The screening length as a function of the quark mass in the Schwinger model. PMID- 9956383 TI - Dirac field on a Minkowski lattice. PMID- 9956386 TI - Phase transition of a fermionic system in a gauge theory. PMID- 9956385 TI - Topologically massive chromodynamics in the perturbative regime. PMID- 9956387 TI - Heterotic string in an arbitrary background field. PMID- 9956388 TI - Fermion-monopole system reexamined. IV. PMID- 9956389 TI - Monopole and dyon supermultiplets. PMID- 9956390 TI - Hidden symmetries of gauge potentials in supersymmetric gauge theories. PMID- 9956391 TI - Mass splittings within composite Goldstone supermultiplets from broken supersymmetry. PMID- 9956393 TI - Two-loop finite-temperature effective potential for the Wess-Zumino model. PMID- 9956392 TI - Possibility of unified preon models with supersymmetry. PMID- 9956395 TI - Trouble with boson loops in Skyrmion physics. PMID- 9956396 TI - Levinson's theorem for Dirac particles moving in a background magnetic monopole field. PMID- 9956394 TI - Study of a three-dimensional quantum-mechanical supersymmetric model with nucleon nucleon-type interaction. PMID- 9956398 TI - Constraints on hadronic current operators in relativistic quantum-mechanical models. PMID- 9956397 TI - Levinson's theorem for Dirac particles with a long-range potential. PMID- 9956399 TI - Perturbation calculations for infrared-divergent problems. PMID- 9956400 TI - Equivalence of the Schwinger model to a scalar-field gauge theory. PMID- 9956401 TI - Spectral flow in a (1+1)-dimensional model. PMID- 9956402 TI - Rotating the Skyrme soliton. PMID- 9956403 TI - Phase transitions and topological excitations in hypergauge theories. PMID- 9956404 TI - Comments on rotational perturbations of Friedmann models. PMID- 9956405 TI - Regularization prescriptions and the axial model. PMID- 9956406 TI - Finite-temperature deconfinement transition in (2+1)-dimensional Z3 gauge theory. PMID- 9956407 TI - Analysis of inclusive KK-bar pi from 11-GeV/c K-p interactions. PMID- 9956408 TI - Inclusive production of multistrange hyperons from 11-GeV/c K-p interactions. PMID- 9956411 TI - Resolving QCD jets beyond leading order: Gluon-decay probabilities. PMID- 9956410 TI - Bose-Einstein correlations in e+e- annihilations in the Upsilon region. PMID- 9956409 TI - Test of s-channel helicity conservation in inelastic rho 0 diffraction in 20-GeV photoproduction. PMID- 9956412 TI - Spin analysis of 0+1-->0+1 and its application to pi +d--> pi +d data. PMID- 9956413 TI - Leading-particle spectrum and impact-parameter distributions at very high energies. PMID- 9956414 TI - Soft-gluon emission in heavy-quarkonia production. PMID- 9956415 TI - Application of chiral perturbation theory to K-->2 pi decays. PMID- 9956416 TI - Nucleon decay in supergravity unified theories. PMID- 9956418 TI - Bound heavy- and light-quark systems in a non-Coulombic logarithmic-potential model. PMID- 9956417 TI - Analytic parametrization of 4He charge form factor. PMID- 9956420 TI - Correlations in color and spin in multiparton processes. PMID- 9956419 TI - Multiparton processes: An application to the double Drell-Yan mechanism. PMID- 9956422 TI - Variational quantum-field-theoretical approach to the chiral bag. PMID- 9956421 TI - Degenerate states and the Kinoshita-Lee-Nauenberg theorem in deep-inelastic scattering. PMID- 9956424 TI - Soliton bag models of hadrons from QCD. PMID- 9956423 TI - Nuclear matter in the crystal soliton bag model. PMID- 9956426 TI - Supersymmetric composite models with preons in two hypercolor representations. PMID- 9956425 TI - Composite model for quarks and leptons. PMID- 9956427 TI - Comparison of cross sections from deep-inelastic neutrino scattering on neon and deuterium. PMID- 9956428 TI - Hyperon polarization asymmetry: Polarized beams and Omega - production. PMID- 9956429 TI - Light gluinos and quark-gluon-plasma formation in relativistic heavy-ion collisions. PMID- 9956431 TI - Note on CP nonconservation in K--> pi pi. PMID- 9956430 TI - Searching for strange matter by heavy-ion activation. PMID- 9956432 TI - Radiative partial width of A1 in current-algebra approach. PMID- 9956433 TI - Single-Majoron emission in micro decay. PMID- 9956434 TI - Excited quarks and Glashow-Iliopoulos-Maiani mechanism. PMID- 9956435 TI - Erratum: Neutrino mass matrix PMID- 9956438 TI - New limits on the production of anomalous nuclear fragments in deuteron-deuteron collisions. PMID- 9956439 TI - Study of inelastic interactions of 340-GeV/c pions with emulsion nuclei. PMID- 9956436 TI - New determination of the Michel parameter in tau decay. PMID- 9956437 TI - Lifetimes, cross sections, and production mechanisms of charmed particles produced by 20-GeV photons. PMID- 9956440 TI - Search for possible superheavy particles in sodium nuclei. PMID- 9956441 TI - On the multiplicity distribution in e+e--->hadrons. PMID- 9956442 TI - Perturbative QCD analysis of the photon structure function. PMID- 9956443 TI - Light-gluino scenario. PMID- 9956444 TI - Photons from strange-quark annihilation in a quark-gluon plasma. PMID- 9956446 TI - P or CP determination by sequential decays: V1V2 modes with decays into l-barAlB and/or q-barAqB. PMID- 9956445 TI - Coherence and Coulomb effects on pion interferometry. PMID- 9956447 TI - Distinguishing a spin-0 technipion and an elementary Higgs boson: V1V2 modes with decays into l-barAlB and/or q-barAqB. PMID- 9956448 TI - Simple tests for CP or P violation by sequential decays: V1V2 modes with decays into l-barAlB and/or q-barAqB. PMID- 9956451 TI - Radiative meson decay in the cloudy bag model. PMID- 9956450 TI - Dipion decay modes of the Upsilon family from a universal epsilon coupling. PMID- 9956449 TI - Right-handed currents, finite neutrino mass, and mass mixings in Kl3+ decays. PMID- 9956453 TI - Detection of W-boson supersymmetric decay modes. PMID- 9956452 TI - Calculation of the decay micro--->e-e+e- nu micro nu -bare. PMID- 9956454 TI - Anomalous quadrupole moment of W in supersymmetry. PMID- 9956455 TI - Nucleon form factors in an independent-quark model based on Dirac equation with power-law potential. PMID- 9956456 TI - Dispersive effects in D0-D-bar0 mixing. PMID- 9956457 TI - Hyperfine splittings in the low-lying nucleon and isobar resonances with ground state quantum numbers. PMID- 9956458 TI - Rho mesons in the Skyrme model. PMID- 9956459 TI - Covariant description of mesons as nontopological solitons. PMID- 9956460 TI - Nonleading radiative contributions to low-energy N=1 supergravity theories. PMID- 9956461 TI - Numerical study of the lattice meson form factor. PMID- 9956462 TI - Lattice and perturbative QCD analysis of exclusive processes. PMID- 9956463 TI - Momentum projection and relativistic boost of solitons: Coherent states and projection. PMID- 9956464 TI - Quasisolitons in the vector-meson sector of the Weinberg chiral model. PMID- 9956465 TI - Bisolitonic ansatz for the Skyrme field. PMID- 9956466 TI - Symmetry breaking and charge operator in SU(9) grand-unification models. PMID- 9956467 TI - Decays of heavy charged Higgs bosons. PMID- 9956469 TI - Phenomenological bounds on flavor-mixing contributions to the down-scalar-quark mass matrix. PMID- 9956468 TI - Proton decay in a nucleus: Effects of the nuclear surface. PMID- 9956470 TI - t-quarkonian energy levels and the strong-interaction coupling constant. PMID- 9956471 TI - Stability of the rotating Skyrmion. PMID- 9956472 TI - Phenomenological model for baryons with radially dependent quark mass. PMID- 9956473 TI - Comment on the suppression of parity-violating asymmetry in sigma (p PMID- 9956474 TI - Erratum: QCD corrections to the decay B--> psi X PMID- 9956475 TI - Analyzing power for pi -p elastic scattering in the energy region of the Roper resonance. PMID- 9956476 TI - Search for monoenergetic photons from Upsilon (1S)--> gamma +X. PMID- 9956478 TI - Solutions to the effective field equations for a proposed gravitational effective action. PMID- 9956477 TI - Nature of the high-energy particles from Cygnus X-3. PMID- 9956479 TI - Gauge invariance and unitarity in higher-derivative quantum gravity. PMID- 9956481 TI - Natural Poincare gauge model. PMID- 9956480 TI - Surface geometry of a rotating black hole in a magnetic field. PMID- 9956483 TI - Hamiltonian formulation of eleven-dimensional supergravity. PMID- 9956482 TI - Chromohydrodynamics in Einstein-Cartan theory. PMID- 9956484 TI - Constraint algebra in eleven-dimensional supergravity. PMID- 9956485 TI - Symmetry breaking in inhomogeneous spacetimes: A tractable example. PMID- 9956487 TI - Global symmetry breaking in two-dimensional flat spacetime and in de Sitter spacetime. PMID- 9956486 TI - Superspace formulation of ten-dimensional N=1 supergravity coupled to N=1 super Yang-Mills theory. PMID- 9956488 TI - Conformally invariant quantum field theory in static Einstein space-times. PMID- 9956489 TI - Consistent picture of supersymmetry breaking at finite temperature: Self consistent loop-expansion method. PMID- 9956490 TI - Dirac quantization in superspace. PMID- 9956492 TI - Renormalizing ( phi3)6 theory in curved space-time. PMID- 9956491 TI - Normalization invariance in quantum field theories. PMID- 9956493 TI - Interacting scalar field theory in general curved space-time. PMID- 9956495 TI - Superluminal reference frames and generalized Lorentz transformations. PMID- 9956494 TI - Calabi-Yau manifolds from arbitrary weighted homogeneous spaces. PMID- 9956496 TI - Correlation functions for homogeneous, isotropic random classical electromagnetic radiation and the electromagnetic fields of a fluctuating classical electric dipole. PMID- 9956497 TI - Stochastic mechanics and the Kepler problem. PMID- 9956499 TI - Fermion-grand-unified-monopole systems as exactly solvable two-dimensional quantum-field-theory problems. PMID- 9956498 TI - Three-cocycle in quantum mechanics. II. PMID- 9956500 TI - Entropy production of superstrings in the very early Universe. PMID- 9956502 TI - Renormalization of QCD with nonvanishing vacuum angle, the UA(1) Ward-Takahashi identity, and decoupling. PMID- 9956501 TI - Anomalous vacuum expectation values. PMID- 9956503 TI - Ultraviolet divergences of the supersymmetric O(N) model in a 1/N expansion. PMID- 9956504 TI - Gauge invariance and mass. I. Abelian case. PMID- 9956506 TI - Extrema of SO(N)-invariant Higgs potentials and their associated mass eigenstates. PMID- 9956505 TI - Gauge invariance and mass. II. Non-Abelian case. PMID- 9956507 TI - Geometrical description of the gauged Dirac-Kahler fields on the lattice. PMID- 9956508 TI - Topological excitations and long-range order. PMID- 9956509 TI - The t expansion and SU(3) lattice gauge theory. PMID- 9956510 TI - Representation of the vacuum wave function of the U(1) lattice gauge theory. PMID- 9956511 TI - SU(2) deconfinement temperature on a body-centered hypercubic lattice. PMID- 9956512 TI - Dimensional reduction near a phase transition. PMID- 9956513 TI - Quenched massive Schwinger model in the infrared approximation. PMID- 9956514 TI - Consistent and covariant anomalies and local cohomology. PMID- 9956515 TI - Supersymmetry and zero-momentum modes. PMID- 9956516 TI - Is the doubly charged monopole stable? PMID- 9956517 TI - Ambiguities of the chiral-anomaly graph in higher dimensions. PMID- 9956518 TI - Gap and Bethe-Salpeter equations in Hamiltonian lattice QCD with Wilson fermions. PMID- 9956519 TI - Perturbative origin of an essential singularity in dimensional renormalization of quadratic divergences. PMID- 9956520 TI - Relativistic two-dimensional field theory with dynamical generation of a superconducting gap. PMID- 9956521 TI - Relativistic string coupled to massless scalar field. PMID- 9956522 TI - Similarity solutions for the self-dual SU(2) fields. PMID- 9956524 TI - Canonical derivation of the gluon propagator in the temporal gauge. PMID- 9956523 TI - Explicit formula for the renormalization-scheme invariants of perturbation theory. PMID- 9956525 TI - Technical aspect in the light-cone gauge. PMID- 9956526 TI - Conservation laws in the supersymmetric sine-Gordon model. PMID- 9956528 TI - Perturbation theory for an anharmonic oscillator. PMID- 9956527 TI - Modest step towards a Young-tableau method for E6. PMID- 9956529 TI - Conditions for nondegeneracy in supersymmetric quantum mechanics. PMID- 9956532 TI - Lattice formulation of the superstring. PMID- 9956530 TI - Conformal transformation of the effective action. PMID- 9956531 TI - Dyonic bound states from local compactification. PMID- 9956534 TI - Measurements of production polarization and decay asymmetry for Xi - hyperons. PMID- 9956533 TI - Observation of A dependence in Koba-Nielsen-Olesen scaling distributions for high energy hadron-nucleus interactions. PMID- 9956535 TI - Measurement of the rate of formation of pi-mu atoms in KL0 decay. PMID- 9956537 TI - Transverse-polarization effects in e+e- collisions: The role of chiral symmetry. PMID- 9956536 TI - Measurement of the resonance parameters and radiative width of the rho + PMID- 9956539 TI - Partons in nuclei. PMID- 9956538 TI - Signals for composite-W+/- production in gamma p collisions. PMID- 9956540 TI - Monte Carlo simulation of jets in the upsilon and t-quarkonium regions. PMID- 9956541 TI - Dynamical basis for Koba-Nielsen-Olesen scaling and its violation. PMID- 9956542 TI - Hadronic transverse energy and QCD. PMID- 9956543 TI - Inclusive nucleon-nucleus scattering and symmetric-hadron-pair production at high Pperp in the relativistic quark model. PMID- 9956544 TI - Muon production by photons from Cygnus X-3. PMID- 9956545 TI - Supplementary evidence for T violation. PMID- 9956546 TI - Discriminating horizontal symmetries from operator analysis and proton-decay experiments. PMID- 9956548 TI - Chiral symmetry and radiative pion decay. PMID- 9956547 TI - Radiative corrections for semileptonic decays of hyperons: "Model-independent" part. PMID- 9956549 TI - Prediction of the electric form factors of the nucleon. PMID- 9956551 TI - Exotic fermions in E6 and the anomalous magnetic moments of leptons. PMID- 9956550 TI - Electric dipole moment of the electron in left-right-symmetric theories. PMID- 9956552 TI - Higgs-boson masses in a supersymmetric extension of the standard model. PMID- 9956553 TI - Comparing the Schrodinger and spinless Salpeter equations for heavy-quark bound states. PMID- 9956554 TI - Heavy-quarkonium systems and the QCD scale parameter Lambda MS PMID- 9956555 TI - Possible evidence for dynamical supersymmetry in the hadron spectrum. PMID- 9956556 TI - CP violation and generation mixing. PMID- 9956557 TI - Baryon axial-vector couplings and SU(3)-symmetry breaking in chiral quark models. PMID- 9956558 TI - Structural arrangement of quarks in three-particle systems. PMID- 9956559 TI - Fokker-Planck stochastic Koba-Nielsen-Olesen solutions, branching processes, and path to hadronization. PMID- 9956560 TI - Relativistic wave equations for the dynamics of two interacting particles. PMID- 9956561 TI - Relativistic quarkonium dynamics. PMID- 9956562 TI - Light fermion bound states in two-particle relativistic quantum mechanics. PMID- 9956563 TI - Energy and Regge residues in quantum-mechanical "QCD" sum rules. PMID- 9956564 TI - Bound on the W-boson electric dipole moment. PMID- 9956566 TI - Quantum-electrodynamic radiative corrections to the decay pi 0--> gamma e+e- PMID- 9956565 TI - Does the A dependence in high-pT jets come from the European Muon Collaboration effect? PMID- 9956567 TI - Corrections to the box-diagram amplitude due to kaon mass. PMID- 9956568 TI - Fermion condensates and weak symmetry breaking in a superstring-based model. PMID- 9956569 TI - Remarks on a composite model for leptons, quarks, and Higgs mesons. PMID- 9956570 TI - Comment on "New observable phases in a supersymmetric extension of the standard model" PMID- 9956571 TI - Erratum: Bounds on higgs-boson masses in a two-doublet extension of the standard model PMID- 9956572 TI - Search for single photons from radiative neutrino or supersymmetric-particle production. PMID- 9956574 TI - Gravity in minesmdashAn investigation of Newton's law. PMID- 9956573 TI - Bag formation in a chiral model. PMID- 9956575 TI - Detecting cold dark-matter candidates. PMID- 9956577 TI - Instability of de Sitter space on short time scales. PMID- 9956576 TI - Axion emission rates in stars and constraints on its mass. PMID- 9956579 TI - A class of viscous magnetohydrodynamic type-I cosmologies. PMID- 9956578 TI - Quantum stress-energy tensors and the weak energy condition. PMID- 9956581 TI - Cosmic strings with cosmological constant. PMID- 9956580 TI - Nonstatic vacuum strings: Exterior and interior solutions. PMID- 9956583 TI - Boundary conditions in quantum cosmology. PMID- 9956582 TI - Cosmic strings as random walks. PMID- 9956584 TI - Quantum blurring of cosmological singularities. PMID- 9956586 TI - Hadamard singularity and quantum states in Bianchi type-I space-time. PMID- 9956585 TI - Spectrum of Hawking radiation and the Huygens principle. PMID- 9956587 TI - Brans-Dicke-type models with nonmetricity. PMID- 9956588 TI - Quasi-Riemannian gravity and spontaneous breaking of the Lorentz gauge symmetry in more than four dimensions. PMID- 9956590 TI - Spin-two fields and general covariance. PMID- 9956589 TI - Classical fluctuations in dissipative quantum systems. PMID- 9956591 TI - Symmetry breaking in six-dimensional Einstein-Maxwell- sigma theory. PMID- 9956592 TI - Effects of acceleration through the Dirac sea. PMID- 9956593 TI - Mean-curvature normal and dual-string models. PMID- 9956594 TI - Does statistical mechanics equal one-loop quantum field theory? PMID- 9956595 TI - Expansion of the one-loop effective action in covariant derivatives. PMID- 9956596 TI - Improved determination of binding energy in field theory using a basis wave functional expansion. PMID- 9956597 TI - Anharmonic oscillator as a test of the coupled-cluster method. PMID- 9956598 TI - Nodal structure of supersymmetric wave functions. PMID- 9956599 TI - Non-Abelian symmetries from higher dimensions in string theories. PMID- 9956601 TI - Nonequilibrium truncation scheme for the statistical mechanics of relativistic matter. PMID- 9956600 TI - Complex Langevin equations and their applications to quantum statistical and lattice field models. PMID- 9956602 TI - Does natural duplexity conceal half-integral fermion number? PMID- 9956603 TI - Spontaneous chiral-symmetry breaking in three-dimensional QED. PMID- 9956604 TI - Chiral superfield four-point function in the N=4 super Yang-Mills theory. PMID- 9956606 TI - Observations on the T lnR term in the quark-antiquark free energy. PMID- 9956605 TI - SU(2) quark potential on a body-centered-hypercubic lattice. PMID- 9956608 TI - Critical behavior near deconfinement. PMID- 9956607 TI - Non-Abelian Debye screening: The color-averaged potential. PMID- 9956610 TI - Current-algebra results in the path-integral framework. PMID- 9956609 TI - Chiral symmetry at finite baryonic density. PMID- 9956611 TI - Phase transition in supersymmetric matter. PMID- 9956613 TI - Absence of spinor loop anomalies involving non-gauge-type external fields. PMID- 9956612 TI - Spontaneous breaking of parity in (2+1)-dimensional QED. PMID- 9956614 TI - Gravitino auxiliary fields of N=1, D=10 supergravity theory. PMID- 9956615 TI - Riemannian contributions to the short-ranged velocity-dependent nucleon-nucleon interaction. PMID- 9956616 TI - Comments on continuous observation in quantum mechanics. PMID- 9956617 TI - Erratum: Fermionic zero modes in two-dimensional field theories PMID- 9956618 TI - Supersymmetric oscillator and the phase problem. PMID- 9956620 TI - Superconducting inductance-bridge transducer for resonant-mass gravitational radiation detector. PMID- 9956619 TI - Quantization of Nambu-Goto strings with new boundary conditions. PMID- 9956621 TI - Black holes in two spacetime dimensions. PMID- 9956622 TI - Class of stationary axisymmetric solutions of Einstein's equations in empty space. PMID- 9956624 TI - Gravitational effects of global strings. PMID- 9956623 TI - String-dominated universe. PMID- 9956625 TI - A mechanism for baryogenesis in supersymmetric inflationary cosmologies. PMID- 9956626 TI - Gauge theories, geometry, and cosmology. PMID- 9956627 TI - Behavior of homogeneous five-dimensional space-times. PMID- 9956628 TI - Torsion and chiral fermions in Kaluza-Klein theories. PMID- 9956629 TI - Progress towards the supersymmetrization of Chern-Simons terms in five dimensional simple supergravity. PMID- 9956630 TI - Supergravity without spinors. PMID- 9956631 TI - Compactification of superstrings and torsion. PMID- 9956633 TI - Renormalization in anti-de Sitter supersymmetry. PMID- 9956632 TI - Lehmann spectral representation for anti-de Sitter quantum field theory. PMID- 9956634 TI - Non-Abelian Aharonov-Bohm effect. PMID- 9956635 TI - Masslessness and light-cone propagation in 3+2 de Sitter and 2+1 Minkowski spaces. PMID- 9956636 TI - Analysis of the compatibility between the Maxwell-Boltzmann distribution and the Rayleigh-Jeans spectrum for classical systems. PMID- 9956638 TI - On the Hill-determinant method. PMID- 9956637 TI - New Schrodinger equations for old: Inequivalence of the Darboux and Abraham-Moses constructions. PMID- 9956639 TI - Effective field equations for expectation values. PMID- 9956640 TI - Minimal theory of quantum electrodynamics. PMID- 9956641 TI - Infrared behavior of three- and four-gluon vertices in Yang-Mills theory. PMID- 9956642 TI - Stability analysis of M4 >= 2 >= 2 in the Einstein-Maxwell system. PMID- 9956643 TI - Kaluza-Klein monopoles in five dimensions. PMID- 9956644 TI - Path-integral solubility of two-dimensional models. PMID- 9956645 TI - Covariant method for soliton matrix elements. PMID- 9956647 TI - Canonical quantization of a two-dimensional model with anomalous breaking of gauge invariance. PMID- 9956646 TI - Quasipoint vertices. PMID- 9956649 TI - Mean-field approximation for Abelian and non-Abelian lattice gauge theories at finite temperature. PMID- 9956650 TI - Foldy-Wouthuysen representation and the relativistic equations of motion for a classical colored, spinning particle. PMID- 9956648 TI - Gauge-matter Potts model: Saddle-point approach and large N. PMID- 9956651 TI - New ghost-free infrared-soft gauges. PMID- 9956652 TI - Lorentz invariance in the mean-field approximation. PMID- 9956653 TI - Hydrogenlike structure of bound-state energy for a fermion and a Dirac dyon with charge Zd= ||q||+1/2. PMID- 9956654 TI - Mass corrections in supersymmetric sine-Gordon theory. PMID- 9956655 TI - Thermodynamic stability of cosmological models. PMID- 9956656 TI - Time variation of coupling constants in Kaluza-Klein cosmologies reexamined. PMID- 9956657 TI - Possible closure conditions in a Kaluza-Klein compactified M4 >= 1-barN-1 model. PMID- 9956658 TI - Induced charges and tunneling in soliton-antisoliton systems. PMID- 9956659 TI - Path-integral derivation of anomalies using dimensional regularization. PMID- 9956660 TI - Renormalized covariant Wigner function of the magnetized vacuum. PMID- 9956661 TI - Fermionic zero modes and violation of the fluctuation-dissipation theorem. PMID- 9956662 TI - 1/N expansion for a Mie-type potential. PMID- 9956663 TI - Imaginary part in thermo field dynamics. PMID- 9956664 TI - Role of Darboux's theorem in supersymmetric quantum mechanics. PMID- 9956665 TI - More about the SU(2) 2(+) glueball state. PMID- 9956666 TI - Surface terms and radiative corrections to the VVA triangle diagram. PMID- 9956668 TI - Low-energy theorems from scale currents. PMID- 9956667 TI - Anomalies in odd-dimensional space-times and zeta-function regularization. PMID- 9956670 TI - On Cooperstock's counterexample to the gravitational-radiation quadrupole formula. PMID- 9956669 TI - Comment on the 4/3 problem in the electromagnetic mass and the Boyer-Rohrlich controversy. PMID- 9956672 TI - Velocity of sound in SU(3) lattice gauge theory. PMID- 9956671 TI - Reply to "On Cooperstock's counterexample to the gravitational-radiation quadrupole formula" PMID- 9956673 TI - One-loop renormalization of the Yang-Mills theory with Dirac fermions in the light-cone gauge. PMID- 9956674 TI - One-loop-order renormalization of the massless Wess-Zumino model in anti-de Sitter space. PMID- 9956675 TI - Fermionic zero modes in two-dimensional field theories. PMID- 9956676 TI - Hadronic decay of the etac(2980). PMID- 9956678 TI - Propagation and secondary production of low-energy antiprotons in the atmosphere. PMID- 9956677 TI - Low-energy p, p-bar, and d vertical intensities at mountain altitude. PMID- 9956679 TI - Nonstandard-Higgs-scalar- and pseudoscalar-boson production in ep and e+e- colliders. PMID- 9956680 TI - Lepton correlations in gauge-boson pair production and decay. PMID- 9956681 TI - Two-photon production in pp and pp-bar collisions. PMID- 9956682 TI - Spin property of heavy hadron in heavy-quark fragmentation: A simple model. PMID- 9956683 TI - Total e+e- annihilation cross section in the charm continuum. PMID- 9956685 TI - Total cross section and extraction of low-energy parameters of Lambda p scattering. PMID- 9956684 TI - Q2 dependence of exclusive meson production in two-photon reactions. PMID- 9956687 TI - Transverse-momentum distribution of pi 0 and its product gamma rays. PMID- 9956686 TI - Effects of quark compositeness at the Superconducting Super Collider. PMID- 9956689 TI - Exclusive decays of a heavy pseudoscalar. PMID- 9956688 TI - Jets as a probe of quark-gluon plasmas. PMID- 9956690 TI - Photodecay amplitudes in a flux-tube potential model for baryons. PMID- 9956692 TI - Dinucleon decay in the nucleus: A quark-model analysis. PMID- 9956691 TI - Two Higgs doublets and heavy-quarkonium decays. PMID- 9956693 TI - Two-photon decays of scalar and pseudoscalar bosons in supersymmetry. PMID- 9956694 TI - Neutrino masses and proton decay modes in SU(3) x SU(3) x SU(3) trinification. PMID- 9956695 TI - General upper bounds on the light-neutral-Higgs-boson mass in minimal low-energy supergravity. PMID- 9956696 TI - Spin splittings in heavy quarkonia. PMID- 9956697 TI - Scale anomaly and the scalars. PMID- 9956698 TI - Why the nonrelativistic potential model and the ultrarelativistic bag model give the same spectra. PMID- 9956699 TI - Current algebra and the cloudy-bag model. PMID- 9956701 TI - Isospin as a spontaneously broken symmetry of the electroweak interactions. PMID- 9956700 TI - Soft-pion corrections to the Skyrme soliton. PMID- 9956703 TI - Branching ratios of b-flavored mesons. PMID- 9956702 TI - Study of eta formation in photon-photon collisions. PMID- 9956704 TI - Do heavy quarkonia have stringlike behavior? PMID- 9956706 TI - Erratum: Are there baryons which contain constituent gluons? PMID- 9956705 TI - Realistic supersymmetric preon models. PMID- 9956708 TI - Time variation of fundamental constants, primordial nucleosynthesis, and the size of extra dimensions. PMID- 9956707 TI - Rephasing invariants and CP violation. PMID- 9956709 TI - Evolution of cosmic strings. PMID- 9956710 TI - Cosmic and local mass density of "invisible" axions. PMID- 9956711 TI - Astrophysical axion bounds diminished by screening effects. PMID- 9956713 TI - Membrane viewpoint on black holes: Properties and evolution of the stretched horizon. PMID- 9956712 TI - Invisible axions and the QCD phase transition in the early Universe. PMID- 9956714 TI - Stochastic quantization of Einstein gravity. PMID- 9956715 TI - Quantum gauge fields at high curvature. PMID- 9956716 TI - Topology change and monopole creation. PMID- 9956717 TI - Fields in nonaffine bundles. I. The general bitensorially gauge-covariant differentiation procedure. PMID- 9956718 TI - Fields in nonaffine bundles. II. Gauge-coupled generalization of harmonic mappings and their Bunting identities. PMID- 9956719 TI - Gravitational amplification and attenuation as part of the mutual interaction of quantum fields in curved space-times. PMID- 9956720 TI - Higher-derivative operators and DeWitt's WKB ansatz. PMID- 9956722 TI - Feynman path integral and the interaction picture. PMID- 9956721 TI - Gauge invariance of the one-loop effective potential in Md >= 1 Kaluza-Klein theory. PMID- 9956724 TI - Wheeler-Feynman dynamics of spin-1/2 particles. PMID- 9956723 TI - Feynman path integral and the photon. PMID- 9956726 TI - Constraints and equations of motion in supersymmetric Yang-Mills theories. PMID- 9956725 TI - New families of isospectral Hamiltonians. PMID- 9956728 TI - Topological invariants for Dirac operators on open spaces. PMID- 9956727 TI - Path-integral derivation of gauge and gravitational chiral anomalies in theories with vector and axial-vector couplings in arbitrary even dimensions. PMID- 9956729 TI - Is the chiral angle related to the vacuum charge? A study in one dimension. PMID- 9956730 TI - When is the central charge of the Virasoro algebra in string theories in curved space-time not a numerical constant? PMID- 9956731 TI - Proof of one-loop finiteness of type-I SO(32) superstring theory. PMID- 9956732 TI - Eigensolutions of the light-cone equation for a scalar field model. PMID- 9956733 TI - Spontaneous symmetry breaking in the effective potential. PMID- 9956734 TI - Thomas-Fermi approximation to functional determinants in external gauge potentials. PMID- 9956736 TI - Monte Carlo study of the four-dimensional anisotropic U(1) gauge theory (lattice dimensional reduction). PMID- 9956735 TI - First-order phase transition in lattice QCD at finite temperature with light fermions: An analytical study. PMID- 9956738 TI - Saddle-point instability in models of chiral-symmetry breaking. PMID- 9956737 TI - Color radiation in the classical Yang-Mills theory. PMID- 9956739 TI - Evaluation of the chiral anomaly by the stochastic quantization method. PMID- 9956740 TI - Nonquenched order-parameter estimates in massive two-dimensional QED by an infrared method. PMID- 9956741 TI - Gauge-invariant energy-momentum tensor for massive QED. PMID- 9956743 TI - Chaos in Yang-Mills equations. PMID- 9956742 TI - Potential scattering and large-N expansions. PMID- 9956744 TI - Dimensional reduction and higher-order topological invariants: Descent by even steps and applications. PMID- 9956745 TI - Construction of nondegenerate non-Abelian solutions and Coulomb-type solution for the same charge distribution in SU(2) Yang-Mills theory. PMID- 9956746 TI - Incompatibility of stochastic regularization and Zwanziger's gauge fixing. PMID- 9956747 TI - Stochastic approach to the large-N limit. PMID- 9956748 TI - Born-Oppenheimer approximation and the origin of Wess-Zumino terms: Some quantum mechanical examples. PMID- 9956749 TI - Path-integral bosonization for massive fermion models in two dimensions. PMID- 9956750 TI - Gravitational anomalies and the Goldstone-Wilczek current. PMID- 9956751 TI - Lee-Weinberg bound reexamined. PMID- 9956752 TI - Transition of rotating Bianchi type-IX cosmological model into an inflationary era. PMID- 9956753 TI - Erratum: Superstring cosmology PMID- 9956754 TI - Measurement of the pi-->e nu branching ratio. PMID- 9956755 TI - Study of the radiative decay J/ psi --> gamma rho rho. PMID- 9956757 TI - Searching for supersymmetry in high-energy cosmic-ray interactions. PMID- 9956756 TI - Neutrino-induced meson production in nucleon-decay detectors. PMID- 9956759 TI - Polarization effects in production and decay of Z0. PMID- 9956758 TI - Cygnus X-3 events and very-high-energy photonuclear cross sections. PMID- 9956761 TI - K factors for processes involving real photons. PMID- 9956760 TI - Jets-plus-missing-momentum events in electron-positron annihilation at the Z0 peak. PMID- 9956762 TI - DD-bar correlations in fusion and cluster models. PMID- 9956763 TI - Statistical approach to nondiffractive hadron-hadron collisions: Multiplicity distributions and correlations in different rapidity intervals. PMID- 9956764 TI - Dimuons from gluinos. PMID- 9956765 TI - How much strangeness production is there in ultrarelativistic nucleus-nucleus collisions? PMID- 9956766 TI - Pion interferometry of quark-gluon plasma. PMID- 9956767 TI - Transverse-momentum behavior of jets from generalized Altarelli-Parisi equations. PMID- 9956769 TI - Cabibbo-angle-favored D-->PP and D-->VP decays: A dispersion approach. PMID- 9956768 TI - Mechanism for coherent production of pions from the decay of resonances. PMID- 9956770 TI - Induced second-class form factors in Sigma - beta decay. PMID- 9956771 TI - Constituent-quark description of nonleptonic hyperon decays. PMID- 9956773 TI - New four-quark Delta S=2 local operator. PMID- 9956772 TI - Theoretical foundation for treating decays allowed by the Okubo-Zweig-Iizuka rule and related phenomena. PMID- 9956774 TI - M0-M-bar0 matrix elements in a relativized quark model. PMID- 9956775 TI - Heavy-fermion contributions to Delta mZ, Delta mW, Delta sin PMID- 9956776 TI - Evolution of relativistic multiquark systems. PMID- 9956778 TI - Skyrmion phenomenology in the standard electroweak model. PMID- 9956777 TI - Glueball solitons. PMID- 9956779 TI - Symmetry-breaking patterns in QCD with 27 scalars. PMID- 9956780 TI - Exact dependence of multiquark operators on the number of colors. PMID- 9956781 TI - Saturation of color forces and nuclear binding. PMID- 9956782 TI - New kind of chiral bag model. PMID- 9956783 TI - Distorted-field approximation to the static pion potential. PMID- 9956784 TI - N=1 supergravity grand unified theories with noncanonical kinetic energy terms. PMID- 9956785 TI - Low-energy phenomenology of some supersymmetric E6-breaking patterns. PMID- 9956786 TI - Search for D production in pion-nucleon interactions. PMID- 9956787 TI - e+e---> gamma + missing neutrals: Neutrino versus photino production. PMID- 9956788 TI - D-wave amplitude of pi pi scattering and nucleon static properties in the Skyrme model. PMID- 9956789 TI - CP violation in charged-kaon decay. PMID- 9956790 TI - Scalar-meson contribution to chiral Lagrangian and nonleptonic K decays. PMID- 9956791 TI - QCD corrections to the decay B--> eta cX. PMID- 9956792 TI - Anomalous current commutators in the nonlinear sigma model. PMID- 9956793 TI - Cloudy bag model, the " sigma " meson, and pi N scattering. PMID- 9956794 TI - Elastic pp-bar and pp scattering up to sqrt s =546 GeV and the flavored perturbative Reggeon field theory. PMID- 9956795 TI - Is D0--> phiK-bar0 really a clear signal for the annihilation diagram? PMID- 9956797 TI - Generic instabilities in first-order dissipative relativistic fluid theories. II. Havas-Swenson-type theories. PMID- 9956796 TI - Neutrino mass limits from the Fritzsch mass matrix. PMID- 9956798 TI - c-boundary of Taub's plane-symmetric static vacuum spacetime. PMID- 9956800 TI - Inertial systems related to the kinematics of discrete mass distributions. PMID- 9956799 TI - Generalized proof of a mass-monopole criterion. PMID- 9956801 TI - Gauged N=4, d=6 Maxwell-Einstein supergravity and "antisymmetric-tensor Chern Simons" forms. PMID- 9956802 TI - Gravitational Casimir energy in even dimensions. PMID- 9956803 TI - Effects of quantum fields on singularities and particle horizons in the early universe. IV. Initially empty universes. PMID- 9956804 TI - Gauge-invariant perturbations in a universe with a collisionless gas and a fluid. PMID- 9956805 TI - On the relic, cosmic abundance of stable, weakly interacting massive particles. PMID- 9956806 TI - Schwarzschild radial functions. PMID- 9956807 TI - Feynman Green function inside a Schwarzschild black hole. PMID- 9956809 TI - Back reaction and the small-mass regime. PMID- 9956808 TI - Vacuum energy density near static distorted black holes. PMID- 9956811 TI - Three-plus-one formulation of Regge calculus. PMID- 9956810 TI - Thermodynamic instability of de Sitter space. PMID- 9956812 TI - Functional formulation of Regge gravity. PMID- 9956813 TI - Topological solitons in Kaluza-Klein theories. PMID- 9956814 TI - Quantum mechanics of measurements distributed in time. A path-integral formulation. PMID- 9956816 TI - Second-order wave equation for spin-1/2 fields. II. The Hilbert space of the states. PMID- 9956815 TI - Grassmann oscillator. PMID- 9956818 TI - Discrete-time quantum mechanics. II. Systems with several degrees of freedom. PMID- 9956817 TI - Covariant quantization of superstrings based on Becchi-Rouet-Stora invariance. PMID- 9956819 TI - Electromagnetic interactions in multiconnected spaces. PMID- 9956820 TI - Temperature-dependent anharmonic oscillator: A Hartree approach. PMID- 9956821 TI - Baryonlike and mesonlike solitons in a one-dimensional Dirac model of extended particles. PMID- 9956823 TI - Graph rules for functions of the time-evolution operator. PMID- 9956822 TI - Temperature-induced interaction: lambda phi4 theory. PMID- 9956825 TI - Dynamically selected vacuum field configuration in massless QED. PMID- 9956824 TI - Levinson's theorem for potentials with Coulomb tails. PMID- 9956826 TI - Spontaneous breaking of global symmetries in supersymmetric theories. PMID- 9956827 TI - Renormalization-group equations in broken supersymmetric theories using superspace methods. PMID- 9956828 TI - Grand unification of fermion generations: Neutrino masses and cosmological constraints. PMID- 9956829 TI - Chiral-symmetry restoration at finite densities in Coulomb-gauge QCD. PMID- 9956830 TI - U(1) lattice gauge theory in the electric-field representation. PMID- 9956831 TI - Static quark-antiquark potential with renormalization-group-improved lattice action. PMID- 9956832 TI - Variations on the Langevin equation for lattice QCD with fermions. PMID- 9956834 TI - Geometric view on topologically massive gauge theories. PMID- 9956833 TI - Gluonic correlations and lattice hadron structure. PMID- 9956835 TI - Color screening and topological index in the classical Yang-Mills theory with sources. PMID- 9956836 TI - Chiral effective action from anomalies. PMID- 9956837 TI - Zero-energy modes, charge conjugation, and fermion number. PMID- 9956838 TI - Force on a charge in the space-time of a cosmic string. PMID- 9956839 TI - Dynamics of the semiclassical Einstein equations. PMID- 9956840 TI - beta functions of the four-point coupling constants in a new class of gauge theory. PMID- 9956841 TI - Bulk-viscosity-driven inflationary model. PMID- 9956843 TI - Looking for colored leptons. PMID- 9956842 TI - Formation of delta(980) and A2(1320) in photon-photon collisions. PMID- 9956845 TI - Transverse momenta in minimum-bias events at collider energies. PMID- 9956844 TI - Pion-nucleon scattering in the cloudy bag model. PMID- 9956847 TI - Conformal symmetry and exclusive processes beyond leading order. PMID- 9956846 TI - Extended-technicolor signatures at the Superconducting Super Collider. PMID- 9956848 TI - Vector-boson decay modes of the nucleon in N=1 supergravity model. PMID- 9956849 TI - Glueball theory of the theta(1700). PMID- 9956850 TI - On the mixing and production of exotic fermions in E6. PMID- 9956851 TI - Extra fermions in E6 superstring theories. PMID- 9956852 TI - Mass spectrum of low-lying baryons in the ground state in a relativistic potential model of independent quarks with chiral symmetry. PMID- 9956853 TI - Chiral model of the nucleon: Projecting the hedgehog as a coherent state. PMID- 9956854 TI - Quantum-chromodynamic evolution of the baryon system. PMID- 9956855 TI - Determination of baryon magnetic moments from QCD sum rules. PMID- 9956856 TI - Possible effect of glueball on 0++-meson nonet spectrum. PMID- 9956857 TI - Dynamical gluons in low-energy mesons. PMID- 9956858 TI - Solitary waves in a Skyrmion-quark Lagrangian. PMID- 9956859 TI - Effective Lagrangian for Skyrmion physics. PMID- 9956860 TI - Two-fluid model of the Skyrmion. PMID- 9956861 TI - Implications of E PMID- 9956863 TI - Spin depolarization of a polarized antiproton beam by electron cooling. PMID- 9956862 TI - Spontaneous parity violation and Higgs-meson masses in a composite model for leptons, quarks, and Higgs mesons. PMID- 9956864 TI - Luminosity monitoring and search for an e through e gamma scattering at e+e- colliders. PMID- 9956865 TI - Detector calibration, luminosity monitoring, and search for an e at DESY HERA. PMID- 9956866 TI - Twist-4 corrections to the asymmetry in polarized-lepton scattering. PMID- 9956868 TI - Relativistic effects in charmonium radiative decays: Is a v2/c2 expansion good enough? PMID- 9956867 TI - Creation of relativistic positronium. PMID- 9956869 TI - Radiative corrections due to enhanced Yukawa couplings. PMID- 9956870 TI - SU(3) breaking and the H dibaryon. PMID- 9956872 TI - On the Z4 model of flavor mixing. PMID- 9956871 TI - Clustering in a quark gas. PMID- 9956874 TI - Erratum: Tensor particles A2(1320), f(1270), and f'(1525) and the decay rate of K1--> gamma gamma PMID- 9956873 TI - Reply to "On the Z4 model of flavor mixing" PMID- 9956875 TI - Pion-nucleon scattering and QCD interactions. PMID- 9956876 TI - On the interpretation of the European Muon Collaboration effect. PMID- 9956877 TI - Possibility of detecting heavy neutral fermions in the Galaxy. PMID- 9956878 TI - Solar System constraints and signatures for dark-matter candidates. PMID- 9956879 TI - Effects of neutron-star superconductivity on magnetic monopoles and core field decay. PMID- 9956881 TI - Oppenheimer-Snyder collapse in polar time slicing. PMID- 9956880 TI - Black-hole thermodynamics and the Euclidean Einstein action. PMID- 9956882 TI - Transfer equation in accelerated media. PMID- 9956883 TI - Finite-dimensional Einstein-Maxwell-scalar field system. PMID- 9956884 TI - Quantum fluctuation-dissipation theorem for general relativity. PMID- 9956885 TI - Cosmological perturbations in Kaluza-Klein models. PMID- 9956886 TI - Inflation in quantum cosmology in higher dimensions. PMID- 9956887 TI - Cosmic strings and the formation of galaxies and clusters of galaxies. PMID- 9956888 TI - Fluctuations from cosmic strings and the microwave background. PMID- 9956890 TI - Evolution of evaporating black holes in an inflationary universe. PMID- 9956889 TI - Singularity-free cosmology: A simple model. PMID- 9956891 TI - Gauge field theory of gravity. PMID- 9956892 TI - Pseudoclassical description for a nonrelativistic spinning particle. I. The Levy Leblond equation. PMID- 9956893 TI - Pseudoclassical description for a nonrelativistic spinning particle. II. Classical content. PMID- 9956895 TI - Proposed experimental test of Bell's inequality in nuclear beta decay. PMID- 9956894 TI - s-equivalent Lagrangians in generalized mechanics. PMID- 9956896 TI - Stochastic dynamical reduction theories and superluminal communication. PMID- 9956897 TI - Unsharp reality and joint measurements for spin observables. PMID- 9956898 TI - Path integrals and the solution of the Schwinger model in curved space-time. PMID- 9956899 TI - Isometric operators, isospectral Hamiltonians, and supersymmetric quantum mechanics. PMID- 9956901 TI - Extended supersymmetry breaking at finite temperature: The O'Raifeartaigh model. PMID- 9956900 TI - Gauge fields, quantum interference, and holonomy transformations. PMID- 9956902 TI - Gaussian effective potential. III. phi6 theory and bound states. PMID- 9956903 TI - Three- and four-particle bound states in scalar field theory. PMID- 9956904 TI - One-loop-order renormalization of the massive Wess-Zumino model in anti-de Sitter space. PMID- 9956905 TI - Thermodynamics in Kaluza-Klein theories. PMID- 9956906 TI - Consistent method of truncating the electron self-energy in nonperturbative QED. PMID- 9956907 TI - Self-consistent, Poincare-invariant and unitary three-particle scattering theory. PMID- 9956908 TI - Angular momentum and spin within a self-consistent, Poincare-invariant and unitary three-particle scattering theory. PMID- 9956909 TI - Perturbative Ward identities for Yang-Mills field theory stochastically quantized. PMID- 9956910 TI - Matrix methods in discrete-time quantum mechanics. PMID- 9956911 TI - Lattice gauge theory: Hamiltonian, Wilson fermions, and action. PMID- 9956912 TI - Numerical results for the line-line correlation length near the SU(2) deconfining phase transition. PMID- 9956913 TI - Ensemble projector Monte Carlo method, studying the lattice Schwinger model in the Hamiltonian formulation. PMID- 9956915 TI - U(1) problem on a lattice: Strong-coupling limit. PMID- 9956914 TI - Nonperturbative study of hadronization with heavy sources. II. Effects of flavor mutual screening in the two-species Schwinger model. PMID- 9956916 TI - Parallelizing torsion and anomalies. PMID- 9956918 TI - Instantons with noise: Equations for two-dimensional models. PMID- 9956917 TI - Stochastic regularization of fermions. PMID- 9956919 TI - Metastability of solitons in a generalized Skyrme model. PMID- 9956920 TI - Model of confinement in (2+1)-dimensional QCD. PMID- 9956921 TI - Coupling the spinning string to an antisymmetric tensor field and quarks with spin. PMID- 9956922 TI - Finite-lattice-spacing corrections to masses and g factors on a lattice. PMID- 9956924 TI - Attraction/repulsion between like charges and the spin of the classical mediating field. PMID- 9956923 TI - Normal-ordering prescription for evaluation of the central charge of Kac-Moody algebra. PMID- 9956925 TI - Time-energy Heisenberg-type relations for nonlinear classical fields. PMID- 9956926 TI - Spontaneous breakdown of supersymmetry at nonzero temperatures. PMID- 9956927 TI - Goldstone fermion at nonzero temperatures. PMID- 9956928 TI - Stability of an extended model of the elctron. PMID- 9956929 TI - Comments on charge-nonconservation effects. PMID- 9956931 TI - On the connection between the stochastic vector-meson field and the Euclidean vector field. PMID- 9956930 TI - Interaction of fermions with black holes. PMID- 9956933 TI - Erratum: Fractional charge and zero modes for planar systems in a magnetic field PMID- 9956932 TI - On the connection between the stochastic quantization of the vector-meson field and the Euclidean theory. PMID- 9956934 TI - Use of ghosts in the description of physical states. PMID- 9956936 TI - Self-contained framework of stochastic mechanics for reconstructing the Onsager Machlup theory. PMID- 9956935 TI - Matter coupling in higher-derivative supergravity. PMID- 9956937 TI - Observation of double phi-meson production in 400-GeV/c proton-nucleon interactions. PMID- 9956939 TI - Elastic p-p scattering amplitudes at 6 GeV/c. PMID- 9956938 TI - Study of polarized proton diffraction dissociation in the reaction p PMID- 9956941 TI - Signatures of a second heavy neutral vector boson in e+e- annihilation. PMID- 9956940 TI - QCD at collider energies. PMID- 9956942 TI - Burning of baryon-rich quark-gluon plasmas. PMID- 9956943 TI - Model of heavy-ion collisions in the few-GeV region. PMID- 9956944 TI - Restrictions on primaries responsible for correlated muon events at Soudan. PMID- 9956945 TI - Mirror-lepton phenomenology in a left-right model with ultralight Dirac neutrinos. PMID- 9956946 TI - Analysis of the WW gamma vertex: Form-factor and anomalous-magnetic-moment effects. PMID- 9956947 TI - Spectral-function sum rules for W boson in the weak- and strong-coupling versions of the standard model. PMID- 9956948 TI - Experimental implications of heavy, isosinglet quarks and leptons. PMID- 9956949 TI - Prediction of the four-generation Kobayashi-Maskawa matrix. PMID- 9956950 TI - Factorization property of the deuteron. PMID- 9956951 TI - Possible anomalies in the bb-bar spectrum and their theoretical interpretation. PMID- 9956953 TI - Analytic bounds on all light-Higgs-boson masses from supergravity. PMID- 9956952 TI - Q PMID- 9956954 TI - MIT bag model with chiral solitons. PMID- 9956955 TI - Fermion mass hierarchy, Kobayashi-Maskawa matrix, and weak and strong CP solution with a non-Abelian family symmetry. PMID- 9956956 TI - Symmetry breaking of SO(10) by the 210-dimensional Higgs boson and Michel's conjecture. PMID- 9956957 TI - Unification of electroweak and strong interactions without grand unification. PMID- 9956958 TI - Prompt electron production from the DELCO detector at the SLAC storage ring PEP. PMID- 9956959 TI - Comparison of recent calculations on the W--> tau nu background for monojet events. PMID- 9956960 TI - Neutrino mixings and right-handed currents in Ml2 decays. PMID- 9956962 TI - Implication of the virial theorem on the atomic physics of the nuclearite. PMID- 9956961 TI - Chiral symmetry, nonleptonic hyperon decay, and the Feinberg-Kabir-Weinberg theorem. PMID- 9956963 TI - Concavity of the quarkonium potential. PMID- 9956965 TI - Erratum: Nonleptonic decays of chiral solitons and a possible resolution of the S wave/P-wave puzzle PMID- 9956964 TI - Comment on the twist-4 corrections to semileptonic neutrino scattering. PMID- 9956966 TI - Alpha-particle interactions with nuclei at 12A GeV/c. PMID- 9956967 TI - Search for "subthreshold" production of antiprotons and creation of fractional charges and new particles in relativistic nuclear collisions. PMID- 9956968 TI - Half-life limits on the zero-neutrino and two-neutrino double- beta decay of 76Ge. PMID- 9956969 TI - Are deep underground detectors good gamma -ray telescopes? PMID- 9956970 TI - Measurement of spin-spin correlation parameters in the p-p system at 11.75 GeV/c. PMID- 9956971 TI - Study of the reaction p PMID- 9956972 TI - Inclusive strange-particle production in single-vee events in 200-GeV/c pi -N interactions. PMID- 9956973 TI - Production of Xi 0 and Xi -bar0 hyperons by 400-GeV protons. PMID- 9956974 TI - Determination of the neutrino fluxes in the Brookhaven wide-band beams. PMID- 9956975 TI - Search for right-handed currents in the decay K+--> micro+ nu. PMID- 9956976 TI - New experimental limit on the stability of the electron. PMID- 9956977 TI - Searching for the intermediate-mass Higgs boson. PMID- 9956978 TI - Signals for compositeness in e-e+-->e-e+ and e-e+--> micro- micro+ PMID- 9956980 TI - Looking for colored leptons. II. PMID- 9956979 TI - Fragmentation corrections to triple energy correlations in high-energy e-e+ annihilation. PMID- 9956981 TI - Next-to-leading-order contributions to R= sigma L/ sigma T in QCD. PMID- 9956982 TI - Single-particle distribution in hadron-nucleus scattering and the partition temperature model. PMID- 9956983 TI - Radiative corrections to the ratio of Z- and W-boson production. PMID- 9956984 TI - Production of heavy quarks from W-gluon fusion. PMID- 9956985 TI - Jets in heavy-ion collisions as a probe of QCD flux-tube dynamics at finite temperature. PMID- 9956986 TI - Remarks on the dimension-four chiral Lagrangian. PMID- 9956987 TI - Two-photon decay widths of Higgs bosons in minimal broken supersymmetry. PMID- 9956988 TI - Phenomenology of isosinglet Higgs bosons in extended electroweak models. PMID- 9956990 TI - Magnetic moments of light, charmed, and b-flavored baryons in a relativistic logarithmic potential. PMID- 9956989 TI - B-meson production between the Upsilon (4S) and Upsilon (6S) and the possibility of detecting B-B-bar mixing. PMID- 9956991 TI - Semirelativistic potential model for heavy quarkonia. PMID- 9956992 TI - Pion as a qq-bar soliton bag: Dressing of the nucleon and Delta. PMID- 9956993 TI - Pattern of quark mass matrices and the mixing-angle hierarchy. PMID- 9956994 TI - Simple model of fourth-generation fermions. PMID- 9956995 TI - Z4 symmetry and the fourth generation. PMID- 9956997 TI - Large-n behavior of the deep-inelastic structure functions and the renormalization- and factorization-scheme dependences. PMID- 9956996 TI - Anomaly constraints and new U(1) gauge bosons. PMID- 9956998 TI - Calculation of nonperturbative QCD parameters. PMID- 9956999 TI - Interacting many-gluon systems within the MIT bag model. PMID- 9957000 TI - Hadronic supersymmetry schemes. PMID- 9957001 TI - Spinless-dyon models of composite leptons and quarks. PMID- 9957003 TI - Hydrodynamics and large transverse momenta in high-energy collisions. PMID- 9957002 TI - Consequences of a possible new light pseudoscalar particle. PMID- 9957005 TI - Finite renormalization effects in the induced s-bardH vertex. PMID- 9957004 TI - Stech and Fritzsch hypotheses in the leptonic sector: Addendum to "Neutrino mass limits from the Fritzsch mass matrix." PMID- 9957006 TI - Schematic modeling of vacuum effects in a topological chiral bag. PMID- 9957007 TI - SO(10) with light scalars and an intermediate right-handed mass scale. PMID- 9957008 TI - Comment on Kimel's new representation for electromagnetic mass splittings. PMID- 9957009 TI - Erratum: Right-handed currents, finite neutrino mass, and mass mixings in K+l3 decays PMID- 9957010 TI - Erratum: Glueball theory of the theta (1700) PMID- 9957011 TI - Longitudinal photon polarization in muon pair production at high xF. PMID- 9957012 TI - Inflation and bubbles in general relativity. PMID- 9957014 TI - The R2 cosmology: Inflation without a phase transition. PMID- 9957013 TI - Conjecture on isotope production in the Bianchi cosmologies. PMID- 9957016 TI - Effective potential in an open Kaluza-Klein universe. PMID- 9957015 TI - Does strange matter evaporate in the early Universe? PMID- 9957018 TI - Double-null coordinates for the Vaidya metric. PMID- 9957017 TI - Mechanically modulated microwave cavity for detection of low-frequency gravitational radiation. PMID- 9957019 TI - Features of a relativistic space-time with seven isometries. PMID- 9957020 TI - Stationary axially symmetric exterior solutions in the five-dimensional representation of the Brans-Dicke-Jordan theory of gravitation. PMID- 9957021 TI - Exact superpartners of N=2 supergravity solitons. PMID- 9957022 TI - Quantization of a gauge theory with independent metric and connection fields. PMID- 9957023 TI - Curvature influence on asymptotic freedom and finite-temperature effects in a Bianchi type-II space-time. PMID- 9957024 TI - Hamiltonian dynamics of gauge systems. PMID- 9957025 TI - Covariant factor ordering of gauge systems. PMID- 9957026 TI - Dimensional phase transitions: Spinors, gauge fields, and background gravity on a cell complex. PMID- 9957027 TI - Candidates for the inflaton field in superstring models. PMID- 9957028 TI - Locally supersymmetric string Jacobian. PMID- 9957030 TI - Origin of gauge invariance in string theory. II. The closed string. PMID- 9957029 TI - Conformal subalgebras of Kac-Moody algebras. PMID- 9957031 TI - Spontaneous breaking of global and local symmetries in six-dimensional Einstein Maxwell- sigma theory. PMID- 9957032 TI - Debye scalar potentials for the electromagnetic fields. PMID- 9957033 TI - Gaussian analysis of the Gross-Neveu model. PMID- 9957034 TI - Fermions and the Gaussian effective potential. PMID- 9957035 TI - Fermion-solenoid interactions: Vacuum charge and scattering theory. PMID- 9957036 TI - Gauge anomalies and scattering theory. PMID- 9957037 TI - Approximate determination of the mass gap in quantum field theory using the method of finite elements. PMID- 9957038 TI - Monopoles and the role of matter representations in four-dimensional U(1) lattice gauge theory with Higgs fields. PMID- 9957039 TI - Continuum limit of an SU(2) gauge theory with a scalar doublet. PMID- 9957041 TI - U(1) problem on a lattice. II. Strong-coupling expansion. PMID- 9957040 TI - Connected moments of the Hamiltonian in SU(3) lattice gauge theory. PMID- 9957043 TI - Gluon thermodynamics with an extended plaquette action. PMID- 9957042 TI - Finite-size effects for lattice glueball masses. PMID- 9957044 TI - Correlation and screening in finite-temperature SU(2) gauge theory. PMID- 9957046 TI - Vortices and electrically charged vortices in non-Abelian gauge theories. PMID- 9957045 TI - Deconfinement and chiral-symmetry restoration in finite-temperature lattice QCD. PMID- 9957047 TI - On the stability of the vacuum in supersymmetric QCD. PMID- 9957048 TI - Non-particle-like Goldstone modes in the spontaneous breakdown of symmetry. PMID- 9957049 TI - Simple evaluation of chiral anomalies in the path-integral approach. PMID- 9957051 TI - Spontaneous symmetry breaking in the composite-vector-boson model. PMID- 9957050 TI - Variational approach to (2+1)-dimensional QED with topological mass term. PMID- 9957052 TI - Test of Newton's second law at small accelerations. PMID- 9957053 TI - Einstein-Kalb-Ramond cosmology. PMID- 9957054 TI - Closed-form solutions for the modified potential. PMID- 9957055 TI - Path-integral bosonization for the Abelian Avan-de Vega two-dimensional model. PMID- 9957057 TI - Accurate determination of spectra in discrete-time quantum mechanics. PMID- 9957056 TI - Explicit schemes to solve the Schrodinger field on a Galileo lattice. PMID- 9957058 TI - Relationship between longitudinally polarized vector bosons and their unphysical scalar partners. PMID- 9957060 TI - Response to "Comment on 'Proof of one-loop finiteness of type-I SO(32) superstring theory' " PMID- 9957059 TI - Comment on "Proof of one-loop finiteness of type-I SO(32) superstring theory" PMID- 9957062 TI - Gravitational bags. PMID- 9957061 TI - Erratum: On the relic, cosmic abundance of stable, weakly interacting massive particles PMID- 9957063 TI - Consistency relations for spinning matter in gravitational theories. PMID- 9957064 TI - Study of the decay B--> psi X. PMID- 9957065 TI - Experimental study of the reactions e+e--->e+e- and e+e---> gamma gamma at 29 GeV. PMID- 9957067 TI - Study of noncollinear two-charged-particle events produced in 29-GeV electron positron annihilation. PMID- 9957066 TI - Study of quark fragmentation in e+e- annihilation at 29 GeV: Charged-particle multiplicity and single-particle rapidity distributions. PMID- 9957069 TI - High-energy photoproduction of W bosons. PMID- 9957068 TI - Search for the S meson in antiproton-proton interactions. PMID- 9957070 TI - Perturbative QCD analysis of exclusive pair production of higher-generation nucleons. PMID- 9957071 TI - Scalar-quark production and decay: An exercise in jet spectroscopy. PMID- 9957072 TI - Finite-energy correction to the branching equation for multiplicity distributions. PMID- 9957073 TI - Quark-cluster-model predictions for the nuclear Drell-Yan process. PMID- 9957074 TI - e+e- peaks at 1.8 MeV: Phenomenological constraints on nuclear transitions, axions, and the particle interpretation. PMID- 9957076 TI - Proton decay and lattice QCD. PMID- 9957075 TI - Order- alpha s QCD effects in technipion production and decay. PMID- 9957077 TI - Strong decay of hadrons in a semirelativistic quark model. PMID- 9957079 TI - Searching for possible large CP-violation effects in neutral-charm-meson decays. PMID- 9957078 TI - Systematic study of large CP violations in decays of neutral b-flavored mesons. PMID- 9957081 TI - Radiative neutrino decay in left-right models. PMID- 9957080 TI - Weak decays of the H dibaryon. PMID- 9957083 TI - New contributions to neutrinoless double-beta decay in supersymmetric theories. PMID- 9957082 TI - On muon decay in left-right-symmetric electroweak models. PMID- 9957084 TI - Neutrino oscillations in nonuniform matter. PMID- 9957085 TI - Solving momentum-space integral equations for quarkonia spectra with confining potentials. PMID- 9957086 TI - Semiclassical projection of hedgehog models with quarks. PMID- 9957088 TI - Spectroscopy of Higgs scalars and exotic mesons up to 1 TeV in a composite model. PMID- 9957087 TI - Vector and scalar mesons in the Skyrmion model. PMID- 9957089 TI - Flux tube or bremsstrahlung? PMID- 9957090 TI - Pauli quenching effects in a simple string model of quark/nuclear matter. PMID- 9957091 TI - On the electromagnetic contribution to inclusive production in proton-air collisions in the regime of projectile fragmentation. PMID- 9957092 TI - Modifications in neutrino counting due to additional gauge bosons. PMID- 9957094 TI - Nongauge interactions of vector bosons and rare K decays. PMID- 9957093 TI - Hyperphoton production in W-boson decay. PMID- 9957095 TI - Sum-rule prediction for the masses of L >= 1 levels of quarkonium. PMID- 9957096 TI - Explicit mass formulas for heavy mesons and baryons. PMID- 9957097 TI - Covariant soliton dynamics: Role of the gluon condensate in hadron spectroscopy. PMID- 9957098 TI - Inelastic photoproduction of charged vector bosons. PMID- 9957099 TI - Erratum: Symmetry-breaking patterns in QCD with 27 scalars PMID- 9957100 TI - Truncation of the operator-product expansion for the langleqq-bar>-condensate component of the quark mass. PMID- 9957101 TI - Supersymmetric inflationary cosmology. PMID- 9957102 TI - Gauge-invariant perturbations in anisotropic homogeneous cosmological models. PMID- 9957103 TI - Cosmological models in Barker's theory of gravitation. PMID- 9957104 TI - Evolution of cosmic strings. II. PMID- 9957106 TI - Multipole moments for stationary, non-asymptotically-flat systems in general relativity. PMID- 9957105 TI - Cylindrical waves and cosmic strings of Petrov type D. PMID- 9957107 TI - Distorted black holes in terms of multipole moments. PMID- 9957108 TI - Metric elasticity in a collapsing star: Gravitational radiation coupled to torsional motion. PMID- 9957109 TI - Motion of gravitationally interacting particles in Born-Infeld electrodynamics. PMID- 9957111 TI - Five-dimensional quantum gravity and the residual length. PMID- 9957110 TI - Homogeneous cosmos of Weyssenhoff fluid in Einstein-Cartan space. PMID- 9957112 TI - Graviton propagator in de Sitter space. PMID- 9957113 TI - Weak and strong quantum vacuum: Properties of the different vacua. PMID- 9957114 TI - Quantum vacuum definition for spin-(1/2) fields in Robertson-Walker metrics. PMID- 9957116 TI - Bound-state solutions, invariant scalar products, and conserved currents for a class of two-body relativistic systems. PMID- 9957115 TI - Hadamard and minimal renormalizations. PMID- 9957117 TI - Repeated measurements in stochastic mechanics. PMID- 9957118 TI - Action principle and quantization of gauge fields. PMID- 9957119 TI - Sugawara-Sommerfield construction for some interacting two-dimensional field theories. PMID- 9957120 TI - Strings in background fields: beta functions and vertex operators. PMID- 9957121 TI - Supersymmetric ten-dimensional low-energy limit of superstring theory. PMID- 9957122 TI - String theory in four dimensions with three families of chiral fermions and standard gauge symmetry. PMID- 9957123 TI - Covariant interacting string field theory in the Fock-space representation. PMID- 9957125 TI - Topological solitons and compactified bosonic string. PMID- 9957124 TI - Classification of closed-fermionic-string models. PMID- 9957126 TI - Classical dynamics of strings with rigidity. PMID- 9957127 TI - Cosmological baryon production in spontaneous-CP-violating models without strong CP problem. PMID- 9957128 TI - Quantum dynamics in a time-dependent variational approximation. PMID- 9957129 TI - Yang-Mills theory in the light-cone gauge in the Becchi-Rouet-Stora formalism. PMID- 9957130 TI - Regularization schemes for stochastic quantization. PMID- 9957132 TI - Ghostless Feynman rules in non-Abelian gauge theories. PMID- 9957131 TI - Monopoles in topologically massive gauge theories. PMID- 9957134 TI - Relative charge distributions for quarks in lattice mesons. PMID- 9957133 TI - Propagation properties and condensate formation of the confined Yang-Mills field. PMID- 9957135 TI - Large-N two-dimensional QCD and chiral symmetry. PMID- 9957136 TI - Static quark potential according to the dual-superconductor picture of QCD. PMID- 9957138 TI - Supersymmetric effective action in three dimensions. PMID- 9957137 TI - Non-Abelian Debye screening. II. The singlet potential. PMID- 9957139 TI - Equivalence between the Thirring model and a derivative-coupling model. PMID- 9957140 TI - Stability of chiral-symmetry-breaking solutions in QCD-like theories. PMID- 9957141 TI - Constraint on 't Hooft indices in preon models with complementarity. PMID- 9957142 TI - Comments on a class of similarity solutions of Einstein's equations relevant to the early Universe. PMID- 9957143 TI - Comment on axion emission rates in stars. PMID- 9957144 TI - Comment on "Torsion and chiral fermions in Kaluza-Klein theories" PMID- 9957145 TI - Erratum: Factorization of the Drell-Yan cross section in perturbation theory PMID- 9957147 TI - Erratum: Time-dependent perturbation theory for quaternionic quantum mechanics, with application to CP nonconservation in K-meson decays PMID- 9957146 TI - Erratum: Feynman path integral and the interaction picture PMID- 9957148 TI - Bounds on the validity of Newton's gravitational law from electromagnetic solar deflection. PMID- 9957149 TI - Slowly rotating charged fluid spheres in general relativity. PMID- 9957150 TI - Cylindrical gravitational waves with two degrees of freedom: An exact solution. PMID- 9957152 TI - Anisotropic fluids with multifluid components. PMID- 9957151 TI - Stability of the Schwarzschild black hole in Brans-Dicke theory. PMID- 9957153 TI - Lagrangian dynamics of particles and fluids with intrinsic spin in Einstein Cartan space-time. PMID- 9957155 TI - Kerr black hole as a gravitational lens. PMID- 9957154 TI - Hamiltonian analysis of extra gauge symmetries in an R+T2 theory of gravity. PMID- 9957157 TI - Spectral decomposition of the perturbation response of the Schwarzschild geometry. PMID- 9957156 TI - Quantum source of entropy for black holes. PMID- 9957158 TI - Colliding plane waves in N=1 classical supergravity. PMID- 9957159 TI - Large-scale microwave background fluctuations: Gauge-invariant formalism. PMID- 9957160 TI - Symmetry and variational methods in higher-dimensional theories. PMID- 9957162 TI - One- and two-photon Compton scattering in strong magnetic fields. PMID- 9957161 TI - Cosmic string networks. PMID- 9957163 TI - Classical extended charge subjected to linear forces and Rayleigh-Jeans radiation. PMID- 9957164 TI - A generalization of stochastic mechanics and its relation to quantum mechanics. PMID- 9957165 TI - Unified dynamics for microscopic and macroscopic systems. PMID- 9957166 TI - Minkowski stochastic quantization. PMID- 9957167 TI - Observer-dependent quantum vacua in curved space. PMID- 9957169 TI - Path-integral formulation of real-time finite-temperature field theory. PMID- 9957168 TI - Mass perturbation in the Thirring model. PMID- 9957170 TI - Chiral anomalies, nonminimal couplings, and Kaluza-Klein theory. PMID- 9957171 TI - Conformal superalgebras, massless representations, and hidden symmetries. PMID- 9957172 TI - Superconformal anomalies from the path-integral measure. PMID- 9957173 TI - Fierz identities and invariance of 11-dimensional supergravity action. PMID- 9957174 TI - Supersymmetrization of N=1 ten-dimensional supergravity with Lorentz Chern-Simons term. PMID- 9957175 TI - Stochastic quantization and the tunneling problem. PMID- 9957176 TI - Levinson's theorem for the Klein-Gordon equation. PMID- 9957178 TI - Extension of the gauge technique to broken symmetry and finite temperature. PMID- 9957177 TI - Wess-Zumino action from the Grammer-Yennie approximation. PMID- 9957179 TI - Quantum dynamics of chiral fermions in a model with anomalous breaking of gauge invariance. PMID- 9957180 TI - Complex Langevin equations and lattice gauge theory. PMID- 9957181 TI - Lattice meson electric form factor using Wilson fermions. PMID- 9957183 TI - Preregularization and the structure of loop-momentum ambiguities within quantum corrections to the supercurrent. PMID- 9957182 TI - Induced quantum numbers in (2+1)-dimensional QED. PMID- 9957184 TI - Pseudo-Goldstone bosons in curved space-time. PMID- 9957186 TI - Stability of the minimum solitary wave of a nonlinear spinorial model. PMID- 9957185 TI - Stability under dilations of nonlinear spinor fields. PMID- 9957187 TI - Birkhoff's theorem in a new scalar-tensor theory. PMID- 9957188 TI - Massless fermions and (2+1)-dimensional gravitational effective action. PMID- 9957189 TI - Consistency problems for Kahler supergravity. PMID- 9957190 TI - O(2) string theory with a Wess-Zumino term. PMID- 9957192 TI - Role of nonperturbative field configurations in phase transitions. PMID- 9957191 TI - Mean-field renormalization-group technique for ZN gauge theories. PMID- 9957193 TI - Response to "Role of nonperturbative field configurations in phase transitions." PMID- 9957194 TI - Erratum: Isotropization and homogenization of an anisotropic and inhomogeneous cosmological model during the inflationary era PMID- 9957195 TI - Successive symmetry breaking of a compact Lie group by a single irreducible multiplet of Higgs bosons. PMID- 9957196 TI - Field theory of paths with a curvature-dependent term. PMID- 9957197 TI - Anomalies in conservation laws in the Hamiltonian formalism. PMID- 9957199 TI - Dependence of average characteristics of pi - mesons on number of interacting protons in nucleus-nucleus collisions at 4.2 GeV/c per nucleon. PMID- 9957200 TI - Heavy cosmic rays at sea level. PMID- 9957198 TI - Study of hadron and inclusive muon production from e+e- annihilation at 39.79 <= sqrt s <= 46.78 GeV. PMID- 9957201 TI - Observation of phiK pi decay of the K PMID- 9957202 TI - Charmonium spectroscopy from inclusive psi ' and J/ psi radiative decays. PMID- 9957204 TI - Polarized-e+/-p scattering in a supersymmetric electroweak model. PMID- 9957203 TI - Electron magnetic moment from geonium spectra: Early experiments and background concepts. PMID- 9957205 TI - Photon plus missing energy in polarized e- and e+ collisions. PMID- 9957206 TI - Towards an unambiguous determination of the structure of the hadronic neutral current. PMID- 9957207 TI - Factorization at low x. PMID- 9957208 TI - Heavy-lepton production via vector-boson fusion. PMID- 9957209 TI - Simple model for nuclear stopping power. PMID- 9957210 TI - Strangeness production in ultrarelativistic heavy-ion collisions. I. Chemical kinetics in the quark-gluon plasma. PMID- 9957211 TI - Studies of the hydrodynamic evolution of matter produced in fluctuations in p barp collisions and in ultrarelativistic nuclear collisions. PMID- 9957212 TI - Transverse-flow effects in dilepton emission. PMID- 9957213 TI - Interactions of atmospheric neutrinos in nuclei at low energy. PMID- 9957214 TI - Overcoming a critical background to Higgs-boson detection. PMID- 9957216 TI - Axion mass limits may be improved by pulsar x-ray measurements. PMID- 9957215 TI - Hyperon decays and CP nonconservation. PMID- 9957217 TI - Chiral quark-meson model of N and Delta with vector mesons. PMID- 9957218 TI - Phenomenological analysis of an SO(10) model for lepton-mixing angles and Majorana neutrino masses. PMID- 9957219 TI - Electromagnetism in a gauged chiral model. PMID- 9957220 TI - Strongly coupled standard model. PMID- 9957221 TI - Probing the three-Higgs-boson coupling in heavy-quarkonium decays. PMID- 9957223 TI - New parametrization of the Kobayashi-Maskawa matrix. PMID- 9957222 TI - rho -parameter shift produced by exotic fermions in E6 theories. PMID- 9957224 TI - CP-violating Fritzsch mass matrices. PMID- 9957225 TI - Isospin violation in mesons and the constituent-quark masses. PMID- 9957226 TI - Search for neutron-antineutron oscillation in 16O nuclei. PMID- 9957227 TI - Exclusive radiative Upsilon (1S) decays. PMID- 9957228 TI - Limits on the mass of the right-handed Majorana neutrino. PMID- 9957229 TI - Stringent low-energy mass constraints in no-scale supergravity. PMID- 9957231 TI - Effect of inflation on anisotropic cosmologies. PMID- 9957230 TI - Microwave anisotropies from cosmic strings. PMID- 9957232 TI - Unstable particles and the large- and small-scale dark-matter problems. PMID- 9957233 TI - Microwave-background anisotropy and decaying-cold-particle scenarios. PMID- 9957234 TI - Superconducting cosmic strings. PMID- 9957235 TI - Probing the origin of large inhomogeneities in inflation using a toy quantum mechanical model. PMID- 9957236 TI - Particle production in expanding universes with path integrals. PMID- 9957237 TI - Mikheyev-Smirnov-Wolfenstein enhancement of oscillations as a possible solution to the solar-neutrino problem. PMID- 9957239 TI - Filtering of spacecraft Doppler tracking data and detection of gravitational radiation. PMID- 9957238 TI - Level crossings in solar-neutrino oscillations. PMID- 9957240 TI - Multipole expansions of the general-relativistic gravitational field of the external universe. PMID- 9957241 TI - Instability of flat space for massive gravitational fields. PMID- 9957242 TI - Brans-Dicke theory in general space-time with torsion. PMID- 9957243 TI - Generalized geodesic deviation equation. PMID- 9957244 TI - How to measure the curvature of space-time. PMID- 9957245 TI - Classification of the static vacuum metric with Ricci-flat compactification. PMID- 9957246 TI - Test-particle motion in Einstein's unified field theory. III. Magnetic monopoles and charged particles. PMID- 9957247 TI - Origin of nonunitarity in quantum gravity. PMID- 9957248 TI - Two-dimensional superconformal gravity with the local symmetry supergroups OSP(1||2) x OSP(2||2) and SP(2) x OSP(2||2). PMID- 9957249 TI - Field quantization for accelerated frames in flat and curved space-times. PMID- 9957250 TI - Pseudoclassical model of a particle with arbitrary spin. PMID- 9957252 TI - Finite quantum field theories. PMID- 9957251 TI - Pauli-Villars regularization of the Wess-Zumino model in anti-de Sitter space. PMID- 9957253 TI - Supersymmetric quantum mechanics in a first-order Dirac equation. PMID- 9957255 TI - Exact solution for the equilibrium problem between radiation and classical nonrelativistic extended charges. PMID- 9957254 TI - Dirac quantization of the chiral superfield. PMID- 9957257 TI - String models with twisted currents. PMID- 9957256 TI - Generalized monopole in (4+K)-dimensional Abelian theories. PMID- 9957258 TI - N-quantum calculation of dynamical symmetry breaking in the Nambu-Jona-Lasinio model. PMID- 9957259 TI - Variational approach to classical SU2 gauge theory with spherical symmetry. PMID- 9957260 TI - Monte Carlo and strong-coupling analysis of the phase structure of an SU(2) lattice gauge theory with a mixed action. PMID- 9957262 TI - Infrared treatment of higher anomalies and their consequences. PMID- 9957261 TI - Structure of Yang-Mills field theory in the framework of many-body approximations. PMID- 9957263 TI - Removing bag dynamics from chiral bag models: An illustrative example. PMID- 9957264 TI - Solutions of the Dirac equation for fermions in Skyrme fields. PMID- 9957265 TI - Isoscalar quarks and leptons in an eight-dimensional space. PMID- 9957266 TI - Dynamical breakdown of symmetries in three-dimensional QED. PMID- 9957267 TI - Stability of solutions to the classical SU(3) Yang-Mills theory with external sources. PMID- 9957269 TI - Radiative isotropic cosmologies with extra dimensions. PMID- 9957268 TI - Hidden chiral symmetry in the presence of mass terms. PMID- 9957270 TI - Electromagnetic mass models in general relativity: Lane-Emden-type models. PMID- 9957271 TI - Gravitational coupling at finite temperature. PMID- 9957272 TI - Higher-dimensional topological-conformal massive gravitinos. PMID- 9957273 TI - Compactification of the Chern-Simons term. PMID- 9957274 TI - String model with Dirac-Kahler spinors. PMID- 9957275 TI - Absence of leading divergence in the parity-odd one-loop amplitude of type-I SO(32) superstring theory. PMID- 9957276 TI - Accelerated monopole detector in odd spacetime dimensions. PMID- 9957277 TI - Sextic-oscillator puzzle and its solution. PMID- 9957278 TI - Comment on the finite-temperature behavior of lambda ( phi PMID- 9957279 TI - Comment on the gauging of Dirac-Kahler fermions on lattices. PMID- 9957280 TI - Reply to "Comment on the gauging of Dirac-Kahler fermions on lattices." PMID- 9957281 TI - Erratum: Factorization of soft and collinear divergences in QCD in the Feynman gauge via a background field gauge PMID- 9957282 TI - Erratum: Singularity-free cosmology: A simple model PMID- 9957283 TI - Phase transition induced by cosmic strings. PMID- 9957285 TI - Inconsistency of collective-coordinate quantization of large systems. PMID- 9957284 TI - Limits on hypothesizing new quantum numbers. PMID- 9957286 TI - Strange-particle production in neutrino-neon charged-current interactions. PMID- 9957287 TI - Measurement of the nucleon structure function in iron using 215- and 93-GeV muons. PMID- 9957288 TI - Relativistic Fermi motion and nuclear structure functions. PMID- 9957289 TI - Asymmetries at e+e- colliders from E6 grand unified theories. PMID- 9957291 TI - Axion bremsstrahlung by an electron beam. PMID- 9957290 TI - Invariant amplitudes for qq-barg final states in e+-e- annihilation. PMID- 9957292 TI - Electromagnetic production of spinless neutral particles in heavy-ion collisions. PMID- 9957294 TI - Isobar-width effects in the coupling of nucleon to isobar channels. PMID- 9957293 TI - Six-quark resonance structures in nucleon-nucleon scattering. PMID- 9957296 TI - Depth-intensity relation for large depths in sea water derived from the primary cosmic-ray energy spectrum. PMID- 9957295 TI - Prospects for supersymmetry at the Fermilab collider. PMID- 9957297 TI - Testing the quark-exchange contribution to the nuclear force in K-p atoms. PMID- 9957298 TI - B-meson decays without charmed particles in the final state. PMID- 9957299 TI - QCD corrections for semiphenomenological treatment of heavy-quark decay. PMID- 9957300 TI - Weinberg CP-violation model revisited. PMID- 9957301 TI - Time-dependent CP-violation effects in B0-B-bar 0 systems. PMID- 9957302 TI - Radiative decays of 1(-) quarkonia to )+/-, 1(+), 2(+/-) states. PMID- 9957303 TI - QED between conducting plates: Corrections to radiative mass and g-2. PMID- 9957305 TI - Right-handed neutrinos in scalar leptonic interactions. PMID- 9957306 TI - Terrestrially enhanced neutrino oscillations. PMID- 9957304 TI - Phenomenology of exotic particles in E6 theories. PMID- 9957308 TI - Stech mass matrix with fourth-generation quarks. PMID- 9957307 TI - Quantum-chromodynamic evolution of six-quark states. PMID- 9957310 TI - Electroweak form factors of the Skyrmion. PMID- 9957309 TI - Nucleon axial-vector form factor in perturbative QCD. PMID- 9957311 TI - Chiral-invariant color dielectric model of the nucleon. PMID- 9957312 TI - Dynamical source of mass splitting in an SU(3) bag model. PMID- 9957313 TI - Anomalous magnetic moment of electron and constraint on composite weak interaction bosons. PMID- 9957315 TI - Extra gauge bosons in E6. PMID- 9957314 TI - Framework for composite vector bosons: The stable-particle case. PMID- 9957316 TI - Signatures for technicolor. PMID- 9957317 TI - Survey of a new class of models of CP violation. PMID- 9957318 TI - Size and shape of the interacting Skyrmion. PMID- 9957319 TI - Constant chromomagnetic field in the soliton bag model. PMID- 9957320 TI - Description of the gluon condensate. PMID- 9957322 TI - Economical unification of three families in SO(18). PMID- 9957321 TI - Remarks on dynamical breaking of chiral symmetry and pion properties in the Nambu and Jona-Lasinio model. PMID- 9957323 TI - Quark and lepton generation in the geometrical rishon model. PMID- 9957324 TI - Search for exclusive J/ psi production. PMID- 9957325 TI - Implications of the ultrahigh-energy cosmic-ray spectrum observed by the Fly's Eye detector. PMID- 9957326 TI - On Primakoff production of Sigma 0 hyperons. PMID- 9957327 TI - Tests for the mechanism of hadronic decays of heavy quarkonia. PMID- 9957328 TI - Do results from lattice gauge theories distinguish between different fragmentation models? PMID- 9957329 TI - Testing for light Higgs particles. PMID- 9957330 TI - Note on baryon masses in the Skyrme model. PMID- 9957332 TI - Neutrino mass and baryon-number nonconservation in superstring models. PMID- 9957331 TI - Fine structure of quarkonium in the covariant harmonic-oscillator quark model. PMID- 9957334 TI - Scaling behavior of the heavy-quark potential. PMID- 9957333 TI - Flux-tube model of quark deconfinement at high temperature. PMID- 9957335 TI - Forward-backward asymmetries for e+e--->Z0-->b-barb,t-bart and physics beyond the standard model. PMID- 9957336 TI - Absolute minima and their stability in a new class of SO(10) models. PMID- 9957337 TI - Large-scale anisotropy of the cosmic background radiation in Friedmann universes. PMID- 9957338 TI - Quantum propagation near black holes. PMID- 9957339 TI - Gravitational entropy: Beyond the black hole. PMID- 9957340 TI - Wave effects in gravitational lensing of electromagnetic radiation. PMID- 9957341 TI - Bubble growth and droplet decay in the quark-hadron phase transition in the early Universe. PMID- 9957342 TI - Classical cosmologies from ten-dimensional supergravity. PMID- 9957344 TI - Gravity as the limit of the type-II superstring theory. PMID- 9957343 TI - Five-dimensional gravitational super Chern-Simons terms. PMID- 9957346 TI - Hamiltonian quantization of SL(2,C) gauge theory. PMID- 9957345 TI - Relativistic scattering coherence. PMID- 9957347 TI - Consistency of Hamiltonian diagonalization for field theories in a Robertson Walker background. PMID- 9957348 TI - Photon propagators and the definition and approximation of renormalized stress tensors in curved space-time. PMID- 9957349 TI - Supersymmetry in curved space. PMID- 9957350 TI - Covariant-derivative expansion of the effective action and the Schwinger-Fock gauge condition. PMID- 9957352 TI - Measurement process in relativistic quantum theory. PMID- 9957353 TI - Integrability properties of symmetric-space fields reduced from axially symmetric Einstein and Yang-Mills equations. PMID- 9957351 TI - Finite-temperature instability for compactification. PMID- 9957354 TI - Probing a nonperturbative method on the S matrix of the nonlinear Schrodinger model in the strong-coupling regime. PMID- 9957355 TI - Lorentz invariance and the composite string. PMID- 9957356 TI - Large-order shifted 1/N expansions. PMID- 9957357 TI - Mass of the sine-Gordon soliton in the Hartree approximation. PMID- 9957358 TI - Dynamical aspects of the minimal realization of the composite Nambu-Goldstone superfield. PMID- 9957360 TI - Bound states and asymptotically free quarks. PMID- 9957359 TI - Phase transition in a supersymmetric theory. PMID- 9957362 TI - Systematic search of Abelian gauge theories. PMID- 9957361 TI - Time-dependent perturbation theory for quaternionic quantum mechanics, with application to CP nonconservation in K-meson decays. PMID- 9957363 TI - New elliptic solutions of the Euclidean SU(2) gauge theory. PMID- 9957364 TI - Interaction between solitons in gauge theories. PMID- 9957365 TI - Simplicial pseudorandom lattice study of a three-dimensional Abelian gauge model, the regular lattice as an extremum of the action. PMID- 9957367 TI - Back reaction of evaporating black holes in the presence of inflation. PMID- 9957366 TI - Low-energy meson action from QCD: Extended Skyrme model. PMID- 9957369 TI - Probing the structure of the galactic halo with gamma rays produced by annihilations of weakly interacting massive particles. PMID- 9957368 TI - Vacuum fluctuations outside cosmic strings. PMID- 9957370 TI - Induced angular momentum on superconducting cosmic strings. PMID- 9957371 TI - Supersymmetry and reflective boundary conditions in anti-de Sitter spaces. PMID- 9957373 TI - Comment on "Time variation of fundamental constants, primordial nucleosynthesis, and the size of extra dimensions." PMID- 9957372 TI - Exact parapositroniumlike solution to two-body Dirac equations. PMID- 9957374 TI - Erratum: Parallelizing Torsion and Anomalies PMID- 9957375 TI - Charged-D-meson production in e+e- annihilation at sqrt s =29 GeV. PMID- 9957376 TI - Inclusive Lambda 0 polarization in proton-nucleus collisions at 12 GeV. PMID- 9957377 TI - Spin-parity analysis of p-barp-->E(1420)X. PMID- 9957379 TI - pi N, KN, and K-barN scattering: Skyrme model versus experiment. PMID- 9957378 TI - Search for right-handed currents in muon decay. PMID- 9957380 TI - Koba-Nielsen-Olesen scaling, its violation, and the structure of hadrons. PMID- 9957381 TI - Radiative angular distributions from cc-bar states directly produced by pp-bar annihilation. PMID- 9957382 TI - Strangeness production in ultrarelativistic heavy-ion collisions. II. Evolution of flavor composition in scaling hydrodynamics. PMID- 9957383 TI - Particle physics with cosmic accelerators. PMID- 9957384 TI - The process pi 0-->ee-bar gamma revisited. PMID- 9957386 TI - Analysis of radiative tau decays. PMID- 9957385 TI - Right-handed currents produced by mixing in E6 theories. PMID- 9957388 TI - Electromagnetic form factors and static properties of the nucleon in a relativistic potential model of independent quarks with chiral symmetry. PMID- 9957387 TI - Inverse beta - decay of 40Ar: A new approach for observing MeV neutrinos from laboratory and astrophysical sources. PMID- 9957389 TI - QCD-based relativistic Hartree-Fock calculations for identical quarks. PMID- 9957390 TI - Effects of core motion on static properties of the nucleon. PMID- 9957391 TI - Direct calculation of the six-gluon subprocess. PMID- 9957392 TI - Method of analytic continuation by duality in QCD: Beyond QCD sum rules. PMID- 9957394 TI - Low-energy phenomenology of a realistic composite model. PMID- 9957393 TI - Phase structure of the fermionic system in the SU(2) x SU(2) chiral sigma model. PMID- 9957395 TI - Gauge-symmetry and supersymmetry breaking in SUC(4). PMID- 9957396 TI - SO(10)V x SU(3)H model. PMID- 9957398 TI - Exotic fermions in E6 models and micro-->e gamma. PMID- 9957397 TI - Correction to the width of heavy Higgs bosons: An addendum to "Radiative decay of heavy Higgs bosons." PMID- 9957400 TI - Short-lived axions and kaon decay. PMID- 9957399 TI - Limits on exotic fermions from E PMID- 9957402 TI - Quarkonium energy splittings in perturbative QCD. PMID- 9957401 TI - Center-of-mass corrections in a relativistic potential model. PMID- 9957403 TI - New values for neutrino masses in the context of a horizontal model. PMID- 9957404 TI - Addendum to "Low-energy phenomenology of some supersymmetric E6-breaking patterns." PMID- 9957405 TI - Limits on neutrino oscillations in the Fermilab narrow-band beam. PMID- 9957406 TI - pi NN form factor in the Skyrme model. PMID- 9957407 TI - Effect of interacting particles on primordial nucleosynthesis. PMID- 9957409 TI - Simple model for the inflationary expansion of the early Universe. PMID- 9957408 TI - Limits on cold-dark-matter candidates from deep underground detectors. PMID- 9957410 TI - Gauge freedom of plane-symmetric line elements with semi-plane-symmetric null electromagnetic fields. PMID- 9957412 TI - Classical repulsive gravity and broken Lorentz symmetry. PMID- 9957411 TI - Relativistic effects in local inertial frames. PMID- 9957414 TI - Density matrix of the Universe. PMID- 9957413 TI - Cosmic strings and black holes. PMID- 9957415 TI - Consistency of canonical quantization of gravity and boundary conditions for the wave function of the Universe. PMID- 9957416 TI - Effective potential for the O(N)-symmetric model in static homogeneous spacetimes. PMID- 9957417 TI - New contributions to the cosmological constant. PMID- 9957418 TI - Hadamard function, stress tensor, and de Sitter space. PMID- 9957419 TI - Anomalous but consistent gravity in two dimensions. PMID- 9957420 TI - Classical motions from pseudoclassical spin-1/2 particle models. PMID- 9957421 TI - A reduction of order two for infinite-order Lagrangians. PMID- 9957422 TI - Stochastic representation of arbitrary fermion sectors in supersymmetric quantum mechanics on Riemannian manifolds. PMID- 9957423 TI - Path integrals in parametrized theories: The free relativistic particle. PMID- 9957424 TI - Multiboson Holstein-Primakoff squeezed states for SU(2) and SU(1,1). PMID- 9957425 TI - lambda phi4 theory in a time-dependent space-time. PMID- 9957426 TI - Harmonic superspace formalism and the consistent chiral anomaly in N=1, d=6 supersymmetric Yang-Mills theory. PMID- 9957427 TI - Algebraic structure of open-string interactions. PMID- 9957428 TI - Covariant string field theory. PMID- 9957429 TI - Hamiltonian and Lagrangian constraints of the bosonic string. PMID- 9957430 TI - Temporal-gauge finite-time Feynman rules and Gauss's law. PMID- 9957431 TI - Lattice theories of chiral fermions. PMID- 9957433 TI - Monte Carlo renormalization-group study of SU(2) lattice gauge theory. PMID- 9957432 TI - Numerical study of parity-violating vacuum currents in lattice QED. PMID- 9957435 TI - Vacuum structure and the fermion-boson transformation. PMID- 9957434 TI - Static screening lengths in the gluon plasma. PMID- 9957436 TI - One-loop vertex function in Coulomb-gauge QED. PMID- 9957437 TI - Quantum field theories around a large-Z nucleus. PMID- 9957438 TI - Charge-exchange and helicity-flip scattering in the field of a 't Hooft-Polyakov monopole. PMID- 9957439 TI - Gluon mass in the quenched Eguchi-Kawai model. PMID- 9957440 TI - Dynamical-mass generation in large-N three-dimensional QED. PMID- 9957442 TI - Fermions in the background field of a six-dimensional Abelian monopole. PMID- 9957441 TI - Fractional charges induced on monopoles in grand unified theories. PMID- 9957443 TI - Comment on "Quantum mechanics of measurements distributed in time. A path integral formulation." PMID- 9957444 TI - Erratum: Lee-Weinberg bound reexamined PMID- 9957445 TI - Regularization of open superstring from orientable closed surface. PMID- 9957446 TI - Mixmaster inflation. PMID- 9957447 TI - K-meson production by nu micro-deuterium reactions near threshold: Implications for nucleon-decay searches. PMID- 9957448 TI - Charged-current exclusive pion production in neutrino-deuterium interactions. PMID- 9957449 TI - Measurements of double- and triple-spin parameters in pp elastic scattering between 440 and 560 MeV. PMID- 9957450 TI - Observation of a new structure in the difference between the pp total cross sections for antiparallel and parallel longitudinal spin states. PMID- 9957451 TI - Inclusive hadronic production cross sections measured in proton-nucleus collisions at sqrt s =27.4 GeV. PMID- 9957452 TI - Measurement of the D0 and D+ lifetimes. PMID- 9957454 TI - Neutrino-oscillation experiments at the Gosgen nuclear power reactor. PMID- 9957453 TI - chi b states in exclusive radiative decay of the Upsilon (2S). PMID- 9957455 TI - First results from a 1.1-m-diameter superconducting monopole detector. PMID- 9957456 TI - Higgs-boson production at or near the Z0 peak in electron-positron annihilation. PMID- 9957457 TI - Q2 dependence of exclusive baryon-antibaryon production in photon-photon collisions. PMID- 9957459 TI - Electromagnetic N- Delta transition at high Q2. PMID- 9957458 TI - Forward-backward asymmetry in e+e- annihilation as a probe of new physics from E6 theories. PMID- 9957460 TI - Superclusters and hadronic multiplicity distribution. PMID- 9957461 TI - Sub-Poissonian distribution in hadronic processes. PMID- 9957463 TI - Signatures of heavy-neutrino production at the CERN collider. PMID- 9957462 TI - Trimuon production in pp-bar collisions. PMID- 9957464 TI - Jets in expanding quark-gluon plasmas. PMID- 9957465 TI - Dilepton emission and the QCD phase transition in ultrarelativistic nuclear collisions. PMID- 9957466 TI - Studies of the hydrodynamic evolution of matter produced in fluctuations in p barp collisions and in ultrarelativistic nuclear collisions. II. Transverse momentum distributions. PMID- 9957468 TI - B-->Kl+l- with four generations: Rates and CP violation. PMID- 9957467 TI - One-dimensional hydrodynamics of ultrarelativistic heavy-ion collisions. PMID- 9957470 TI - Neutral hadronic eta ' and eta decays and electromagnetic mixing. PMID- 9957469 TI - D0--> phiK-bar0 decay in the algebraic approach to nonleptonic weak decays. PMID- 9957471 TI - Two-body hadronic decays of exotic quarks in E6 theories. PMID- 9957472 TI - Kobayashi-Maskawa type of hard-CP-violation model with three-generation Majorana neutrinos. PMID- 9957473 TI - Magnetic moments of the nucleon octet in a relativistic quark model with chiral symmetry. PMID- 9957474 TI - Baryons in a relativized quark model with chromodynamics. PMID- 9957475 TI - The iota (1440), anomalous Ward identities, and topological susceptibility for QCD. PMID- 9957476 TI - Structure of light meson multiplets and a semirelativistic model. PMID- 9957477 TI - Neutrino masses and L parity in E6 superstring models. PMID- 9957478 TI - Demibootstrap approach to hadron-spectrum dynamics. PMID- 9957479 TI - CP violations and the Kobayashi-Maskawa matrix. PMID- 9957480 TI - Short- and long-range correlations of produced particles at very high energies. PMID- 9957481 TI - Q2 dependence of the European Muon Collaboration effect. PMID- 9957482 TI - Z0 and test of sea-quark polarization. PMID- 9957483 TI - Production of light pseudoscalar particles in heavy-ion collisions. PMID- 9957484 TI - Bounds for massive neutrinos in the region 1-50 GeV from the micro-e conversion experiment. PMID- 9957485 TI - Production of E6 heavy leptons at supercollider energies. PMID- 9957486 TI - Tests of quantum electrodynamics with two-, three-, and four-photon final states from e+e- annihilation at sqrt s =29 GeV. PMID- 9957487 TI - Electroweak effects in e+e--->e+e- at sqrt s =29 GeV. PMID- 9957488 TI - Inclusive B-meson decays into charm. PMID- 9957489 TI - Measurement of the branching fractions of the tau lepton using a tagged sample of tau decays. PMID- 9957490 TI - Strong-interaction contributions to one-loop leptonic processes. PMID- 9957491 TI - Gauge structures beyond the standard model and 100-GeV mass region. PMID- 9957492 TI - E6-charged-lepton mixing and its effect in e+e- into two Z0 bosons. PMID- 9957493 TI - W-pair production in electron-positron collisions for a rank-5 Wilson-loop-broken E6 model. PMID- 9957494 TI - Beyond leading-order perturbative QCD corrections to gamma gamma -->M+M- (M= pi,K). PMID- 9957495 TI - Unified multiplicity scaling in electron-positron and muon-proton collisions. PMID- 9957496 TI - On the change of scale observed in nuclear deep-inelastic scattering. PMID- 9957498 TI - Bounds on the gKN Sigma 2 coupling constant from positivity and charge-exchange data. PMID- 9957497 TI - Quark exchange in nuclei and the European Muon Collaboration effect. PMID- 9957499 TI - Nucleon-nucleon partial-wave analysis to 1100 MeV. PMID- 9957501 TI - Rapidity dependence of multiplicity distributions and reaction mechanisms of multiparticle production processes. PMID- 9957500 TI - New mechanism for spin effects in large-angle N-N elastic scattering. PMID- 9957502 TI - Missing-pT-plus-jets signal for heavy leptons in pp-bar collisions. PMID- 9957503 TI - Helicity projection techniques for evaluating cross sections of heavy-fermion production and decay via W bosons. PMID- 9957504 TI - Pair production of supersymmetric charged Higgs bosons. PMID- 9957505 TI - Statistical analysis in new-particle searches. PMID- 9957506 TI - Jet-calculus approach including coherence effects. PMID- 9957507 TI - Excess-path-length distribution of fast charged particles. PMID- 9957508 TI - Effects of heavy subdominantly coupled neutrino mixing on l+ polarization in KL0- > pi -l+ nu l decays. PMID- 9957509 TI - beta energy spectrum in charged-hyperon semileptonic decays with improved radiative corrections. PMID- 9957510 TI - Analysis of the decay mechanism of dibaryon resonances. PMID- 9957511 TI - Light-quark meson spectrum in the covariant oscillator quark model with one-gluon exchange effects. PMID- 9957513 TI - Excited weak vector bosons. PMID- 9957512 TI - Fritzsch-Stech model in SO(10). PMID- 9957515 TI - Cross section for hard processes involving two quarks and four gluons. PMID- 9957514 TI - Breaking of some grand unification groups into the electroweak group with an extra U(1) factor. PMID- 9957516 TI - Evaluation of helicity amplitudes. PMID- 9957517 TI - Effective chiral Lagrangian with baryons. PMID- 9957519 TI - Symmetry breakings in supersymmetric quantum chromodynamics with Ncolor PMID- 9957518 TI - Shock phenomena in baryonless strongly interacting matter. PMID- 9957520 TI - Unification of interactions and the constraint on charges in fermion-scalar constituent models. PMID- 9957521 TI - Adler-Weisberger sum rule and hadronic models. PMID- 9957523 TI - Asymmetries in e+e- collisions at the Z0 pole from E6 grand unified theories. PMID- 9957522 TI - Search for single electrons from supersymmetric-particle production. PMID- 9957524 TI - Connection among different approaches to the European Muon Collaboration effect. PMID- 9957525 TI - Direct photon production by pi m beams and the ratio of cross sections by pi - and pi + PMID- 9957526 TI - Production of gamma gamma pairs in quark-gluon plasma and hadron plasma. PMID- 9957528 TI - On the detection of cosmic-background neutrinos by acoustic phonon scattering. PMID- 9957527 TI - Limits on millicharged matter from beam-dump experiments. PMID- 9957529 TI - Asymptotic flavor symmetry and its implication on tau --> rho nu tau and K nu tau branching ratio and ground-state 1(--) meson multiplet. PMID- 9957530 TI - Does the proton contain a pointlike diquark? PMID- 9957531 TI - Magnetic moments of composite W bosons. PMID- 9957532 TI - Erratum: Prospects for supersymmetry at the Fermilab collider PMID- 9957533 TI - Erratum: Spin-dependent phenomena induced by electromagnetic-hadronic interference at high energies PMID- 9957534 TI - Precise measurement of the branching fraction for the decay tau --> nu tau pi. PMID- 9957535 TI - Hidden local symmetry versus massive Yang-Mills theory in the nonlinear chiral Lagrangian. PMID- 9957536 TI - Discontinuity cylinder model of gravitating U(1) cosmic strings. PMID- 9957537 TI - Reheating in the higher-derivative inflationary models. PMID- 9957538 TI - Gravitational particle creation and inflation. PMID- 9957539 TI - Relativistic bubble dynamics: From cosmic inflation to hadronic bags. PMID- 9957540 TI - Mikheyev-Smirnov-Wolfenstein effect in electron-neutrino scattering experiments. PMID- 9957541 TI - Discrete gravity without coordinates. PMID- 9957542 TI - Quantization of the "single-point-gravity" Hamiltonian system. PMID- 9957543 TI - Semiclassical cosmology with a scalar field. PMID- 9957544 TI - Quantum-mechanical noise in an interferometer: Intrinsic uncertainty versus measurement uncertainty. PMID- 9957545 TI - Regular effective action of gauge field theory and quantum gravity. PMID- 9957546 TI - Killing approximation for vacuum and thermal stress-energy tensor in static space times. PMID- 9957547 TI - (1,0) supergravity and the heterotic string. PMID- 9957548 TI - Constraints on nonlinear extensions of the Lorentz group. PMID- 9957549 TI - Distinguishing three-body from two-body nonseparability by a Bell-type inequality. PMID- 9957550 TI - Complementary observables and uncertainty relations. PMID- 9957551 TI - Parity-violating anomalies from stochastic quantization. PMID- 9957552 TI - Discrete-time quantum mechanics. III. Spin systems. PMID- 9957554 TI - Analytical approach to string-induced phase transition. PMID- 9957553 TI - Dynamical symmetry breaking in a de Sitter-invariant vacuum. PMID- 9957555 TI - Properties of Z2 strings. PMID- 9957556 TI - Perturbatively renormalized vertex operator, highest-weight representations of Virasoro algebra, and string dynamics in curved space. PMID- 9957557 TI - CP violation and Yukawa couplings in superstring models: A four-generation example. PMID- 9957558 TI - Preon model and cosmological quantum-hyperchromodynamic phase transition. PMID- 9957559 TI - Bosonization in the chiral Schwinger model. PMID- 9957560 TI - Thermodynamics of the Schwinger and Thirring models. PMID- 9957561 TI - Four-dimensional chiral fermions from a six-dimensional Rarita-Schwinger field. PMID- 9957562 TI - Generalized point-splitting method and Bjorken-Johnson-Low limit for the commutator anomaly. PMID- 9957563 TI - Effective potential in scalar field theory. PMID- 9957564 TI - Gauge theories on a pseudorandom lattice. PMID- 9957566 TI - Flux tubes in lattice gauge theory. PMID- 9957565 TI - Lattice fermions in the Schwinger model. PMID- 9957568 TI - Extended solutions of an SU(2) gauge theory with fermions. PMID- 9957569 TI - Non-Abelian bosonization: Current correlation functions. PMID- 9957570 TI - Nonperturbative effects in the response of a Yang-Mills system to a strong background field. PMID- 9957567 TI - Monopole-antimonopole pair solution of the classical SU(3) Yang-Mills theory. PMID- 9957571 TI - Quantum effects in a model of cosmological compactification. PMID- 9957573 TI - Spinning fluids in general relativity. II. Self-consistent formulation. PMID- 9957572 TI - Ages of the Universe for decreasing cosmological constants. PMID- 9957574 TI - Effective energy of gravitational solitons. PMID- 9957575 TI - Ground state of hydrogen as a zero-point-fluctuation-determined state. PMID- 9957577 TI - theta -dependent energy of a particle on a circle. PMID- 9957578 TI - Particle-spectrum estimates for the quantum field theory phitt- phixx+(m3/ sqrt lambda )sin PMID- 9957576 TI - Identical phase-space constraint structure of three-dimensional QED with or without the Chern-Simons term. PMID- 9957579 TI - Vortices on the string world sheet and constraints on toral compactification. PMID- 9957580 TI - Gauge equivalence of two different IAnsaaumlItze Rfor non-Abelian charged vortices. PMID- 9957581 TI - Supersymmetric calculations of QCD interactions. PMID- 9957582 TI - Erratum: Vacuum energy and dilaton tadpole for the unoriented closed bosonic string PMID- 9957583 TI - Topological mass terms on axion domain walls. PMID- 9957585 TI - Two-photon-exchange continuum contribution to elastic lepton-hadron scattering amplitudes. PMID- 9957584 TI - Search for anomalous particles in high-energy hadron-proton interactions. PMID- 9957586 TI - Perturbative QCD predictions for inclusive production of heavy mesons in e+e- annihilation. PMID- 9957587 TI - Longitudinal-e--beam-polarization asymmetry in e+e--->hadrons. PMID- 9957588 TI - Production of a light pseudoscalar particle in two-photon collisions. PMID- 9957589 TI - Production of spin-one resonances in gamma gamma collisions. PMID- 9957590 TI - Phenomenology of extra E6 neutral gauge bosons in ep collisions. PMID- 9957591 TI - Bose-Einstein correlation and two-body final-state interaction of dipion. PMID- 9957592 TI - Superheavy-quarkonium production and decays: A new Higgs-boson signal. PMID- 9957593 TI - Monte Carlo calculational methods for the generation of events with Bose-Einstein correlations. PMID- 9957594 TI - Transverse momentum in high-energy nuclear collisions: Collective expansion. PMID- 9957595 TI - Radiative corrections to 0+-0+ beta transitions. PMID- 9957596 TI - Remarks concerning the O(Z alpha 2) corrections to Fermi decays, conserved-vector current predictions, and universality. PMID- 9957597 TI - On the possibility of residual S-P interactions and right-handed neutrino singlets. PMID- 9957598 TI - Three-neutrino oscillations and the solar-neutrino experiments. PMID- 9957599 TI - Magnetic moment of Dirac neutrinos. PMID- 9957600 TI - Baryon self-energies due to pion-quark coupling. PMID- 9957601 TI - CP violation through Higgs-boson exchange in left-right-symmetric models. PMID- 9957603 TI - Mass-matrix ansatz and flavor nonconservation in models with multiple Higgs doublets. PMID- 9957602 TI - Fourth-generation quark masses and Fritzsch mass matrices from Abelian family symmetry. PMID- 9957605 TI - Induced toroid structures and toroid polarizabilities. PMID- 9957604 TI - Probing the desert by the two-loop renormalization-group equations. PMID- 9957607 TI - Detecting the radiation amplitude zero in ep-->ep gamma. PMID- 9957606 TI - Contemplating the ultimate accelerator. PMID- 9957608 TI - Multiplicity, rapidity, and rapidity correlations in 800-GeV proton-nucleus interactions. PMID- 9957609 TI - Test of the transverse magneticity of the xi (2.23). PMID- 9957610 TI - Analysis of charm-->PP based on SU(3) symmetry and final-state interactions. PMID- 9957611 TI - New constraints on exotic fermion masses from E6 theories. PMID- 9957612 TI - Hadronic form factors of baryons. PMID- 9957613 TI - Mass splitting of heavy baryon isospin multiplets. PMID- 9957614 TI - Phase transition in a nucleon-antinucleon system. PMID- 9957615 TI - Improved upper limit on flavor-changing neutral-current decays of the b quark. PMID- 9957617 TI - Tau decays involving the eta meson. PMID- 9957618 TI - Superconducting gravity gradiometer for sensitive gravity measurements. I. Theory. PMID- 9957616 TI - Charged-particle multiplicity and angular distributions in proton-emulsion interactions at 800 GeV. PMID- 9957619 TI - Superconducting gravity gradiometer for sensitive gravity measurements. II. Experiment. PMID- 9957620 TI - How reliable are neutrino mass limits derived from SN1987A? PMID- 9957621 TI - Neutrino oscillations and the solar-neutrino problem. PMID- 9957622 TI - Black-hole normal modes: A WKB approach. I. Foundations and application of a higher-order WKB analysis of potential-barrier scattering. PMID- 9957623 TI - Black-hole normal modes: A WKB approach. II. Schwarzschild black holes. PMID- 9957625 TI - Mini-soliton stars. PMID- 9957624 TI - Soliton stars and the critical masses of black holes. PMID- 9957627 TI - Fermion soliton stars and black holes. PMID- 9957626 TI - Scalar soliton stars and black holes. PMID- 9957628 TI - Estimates of the density of dark matter near the center of the Galaxy. PMID- 9957629 TI - Texture: A cosmological topological defect. PMID- 9957631 TI - Cosmic strings coupled with gravitational and electromagnetic waves. PMID- 9957630 TI - Particle creation by a self-coupled scalar field. PMID- 9957633 TI - Test-particle motion in the nonsymmetric gravitation theory. PMID- 9957632 TI - Linear plane waves in dissipative relativistic fluids. PMID- 9957634 TI - Extra gauge symmetries in a weak-field approximation of an R+T2+R2 theory of gravity. PMID- 9957636 TI - Quantum theory of two-dimensional gravity. PMID- 9957635 TI - Fate of singularities in Bianchi type-III quantum cosmology. PMID- 9957637 TI - Massless minimally coupled scalar field in de Sitter space. PMID- 9957638 TI - Vacuum polarization in the gravitational field of a cosmic string. PMID- 9957639 TI - Vacuum stability in rotating spacetimes. PMID- 9957640 TI - Functional measure for quantum field theory in curved spacetime. PMID- 9957641 TI - Kaluza-Klein ansatz for quadratic-curvature theory. A geometrical way to mass hierarchy. PMID- 9957642 TI - Unstable compactification in ten-dimensional theories. PMID- 9957643 TI - Constrained Hamiltonian formalism for unconstrained classical mechanics. PMID- 9957644 TI - Detector inefficiencies in the Einstein-Podolsky-Rosen experiment. PMID- 9957645 TI - Violation of Einstein causality in a model quantum system. PMID- 9957646 TI - Relativistic dynamics and Lorentz contraction. PMID- 9957647 TI - On the calculation of phase shifts produced by complex potentials. III. PMID- 9957649 TI - Operator regularization with superfields. PMID- 9957648 TI - Operator regularization and one-loop Green's functions. PMID- 9957650 TI - Becchi-Rouet-Stora-Tyutin symmetry, differential geometry, and string field theory. PMID- 9957651 TI - Vertex operators for closed strings. PMID- 9957652 TI - Gauge fixing and Becchi-Rouet-Stora-Tyutin transform for strings via moduli. PMID- 9957653 TI - Stochastic quantization and random surface approach to Polyakov string theory. PMID- 9957654 TI - Free heterotic string field theory. PMID- 9957655 TI - Calculating the weak scale in supergravity models. PMID- 9957656 TI - Goldstone theorem at finite temperature and density. PMID- 9957658 TI - Dimensional regularization and the gamma 5 axial anomaly. PMID- 9957657 TI - Effects of the virtual particle number on the S matrix of the ( phi4)1+1 model. PMID- 9957659 TI - Mean-field analysis of deconfinement transition in SU(3) with heavy dynamical quarks at finite baryon-number density. PMID- 9957661 TI - Chiral-symmetry breaking in lattice QCD with two and four fermion flavors. PMID- 9957660 TI - Phenomenological lattice model of the high-temperature phase transition in quantum chromodynamics. PMID- 9957662 TI - Hydrodynamic flow structures and the QCD plasma. PMID- 9957663 TI - Chiral asymmetry and the Atiyah-Patodi-Singer index for the Dirac operator on a four-dimensional ball. PMID- 9957664 TI - Nonlinear O'Raifeartaigh model in four dimensions. PMID- 9957665 TI - Neutrino oscillations and the Landau-Zener formula. PMID- 9957666 TI - Constraints on a vector coupling to baryon number from the Eotvos experiment. PMID- 9957668 TI - Origin of external sources for classical Yang-Mills fields. PMID- 9957667 TI - Finite-temperature and -density renormalization effects in QED. PMID- 9957669 TI - Vacuum charge and induced charge in (2+1)-dimensional space. PMID- 9957671 TI - Does the absence of a phase transition in SU(2) and SU(3) lattice gauge theories with Wilson action really have anything to do with continuum confinement? PMID- 9957670 TI - Attempered renormalization-group scheme for the SU(2)-Higgs model. PMID- 9957672 TI - More on sigma -model beta functions and low-energy effective actions. PMID- 9957673 TI - Erratum: Schwarzschild radial functions PMID- 9957674 TI - Double inflation. PMID- 9957675 TI - Inflation with generalized initial conditions. PMID- 9957676 TI - Inflation from inhomogeneous initial data in a one-dimensional back-reacting cosmology. PMID- 9957677 TI - Classical derivation of black-hole entropy. PMID- 9957678 TI - Higher-dimensional black holes in compactified space-times. PMID- 9957680 TI - Attractor in a superstring model: The Einstein theory, the Friedmann universe, and inflation. PMID- 9957679 TI - First-order formalism treatment of R+R2 gravity. PMID- 9957682 TI - Ultralocal limit of the gravitational field coupled to a scalar field. PMID- 9957681 TI - Equivalence between fourth-order theories of gravity and general relativity: Possible implications for the cosmological singularity. PMID- 9957683 TI - Closed-time-path functional formalism in curved spacetime: Application to cosmological back-reaction problems. PMID- 9957684 TI - Finite-temperature quantum field theory in curved spacetime: Quasilocal effective Lagrangians. PMID- 9957685 TI - Effect of transmission through the Earth on neutrino oscillations. PMID- 9957686 TI - Quantum field theory in the space-time of a cosmic string. PMID- 9957687 TI - Covariant observer-dependent Hamiltonian formalism for the relativistic particle. PMID- 9957689 TI - Scalar Casimir energies in M4 >= N for even N. PMID- 9957688 TI - Fermion fields in the soliton background of Kaluza-Klein theories. PMID- 9957691 TI - Thermal effects of acceleration for a spatially extended electromagnetic system in classical electromagnetic zero-point radiation: Transversely positioned classical oscillators. PMID- 9957690 TI - Zero-point field in a circular-motion frame. PMID- 9957692 TI - Structure of a composite system in motion in relativistic quantum mechanics. PMID- 9957693 TI - Gauge-invariant actions from constraint Hamiltonian dynamics. PMID- 9957694 TI - Consistent factor ordering of constraints may be ambiguous. PMID- 9957695 TI - Novel topological invariants and anomalies. PMID- 9957696 TI - Complete treatment of effective actions within the Gaussian approximation and systematic generalizations. PMID- 9957697 TI - Approaching the critical region of two-dimensional phi4 quantum field theory with post-Gaussian approximations. PMID- 9957699 TI - Dimensional regularization and perturbative solution of the chiral Schwinger model. PMID- 9957698 TI - Nonperturbative method in field theory: The gauge technique. PMID- 9957700 TI - Interacting string field theory and Chern-Simons form. PMID- 9957701 TI - On toroidal compactification of heterotic superstrings. PMID- 9957702 TI - Vacuum energy and dilaton tadpole for the unoriented closed bosonic string. PMID- 9957704 TI - Topologically massive chromodynamics at finite temperature. PMID- 9957703 TI - Background-field quantization and the light-cone planar gauge: An exception to Kallosh's theorem. PMID- 9957705 TI - Renormalized coupling constants by Monte Carlo methods. PMID- 9957706 TI - Monte Carlo calculation for the effective couplings of Polyakov loops. PMID- 9957707 TI - Effective gauge action on a finite-size lattice. PMID- 9957708 TI - Periodic generalizations of static, self-dual SU(2) gauge fields. PMID- 9957710 TI - Symmetry breaking induced by charge density and the entropy of interacting fields. PMID- 9957709 TI - Weyl-Dirac equation for an SU(2) gauge theory with spherical symmetry. PMID- 9957711 TI - Fermion guides: A mechanism for spontaneous breakdown of chiral symmetry in QCD. PMID- 9957712 TI - Thermodynamic properties of the gluon plasma. PMID- 9957713 TI - Gauge theories at finite temperature and chemical potential. PMID- 9957715 TI - Space-time Dirac-Kahler spinors. PMID- 9957714 TI - Heat-kernel regularization of gauge theory. PMID- 9957717 TI - Behavior of coupling constants at high temperature in supersymmetric theories. PMID- 9957716 TI - Mass independence of the minimal-subtraction scheme in dimensional regularization. PMID- 9957718 TI - Stochastic quantization and axial gauges. PMID- 9957719 TI - Two important invariant identities. PMID- 9957720 TI - Response to "Two important invariant identities" PMID- 9957721 TI - Erratum: Meson electric form factor on the lattice PMID- 9957722 TI - Chiral hierarchies and chiral perturbations in technicolor theories. PMID- 9957723 TI - Virasoro conditions, vertex operators, and string dynamics in curved space. PMID- 9957724 TI - Measurement of neutrino-proton and antineutrino-proton elastic scattering. PMID- 9957725 TI - Analyzing power and transversity cross sections for pi +p and pi -p elastic scattering from 471 to 687 MeV/c. PMID- 9957727 TI - Factorization of helicity amplitudes and angular correlations for electroweak processes. PMID- 9957726 TI - Nucleus-nucleus interactions between 20 and 65 GeV per nucleon. PMID- 9957728 TI - Electroweak interference in a new model of b and tau interactions. PMID- 9957729 TI - Phenomenology of an extra neutral gauge boson in electron-positron collisions. PMID- 9957730 TI - Fermionic next-to-leading-order contributions to the longitudinal structure function in QCD. PMID- 9957732 TI - Jets produced in association with W and Z bosons. PMID- 9957731 TI - Inelasticity and leading-particle effect: Momentum and mass distribution of the central fireball in high-energy hadronic interactions. PMID- 9957733 TI - On a new low-mass pseudoscalar boson. PMID- 9957735 TI - Partial-decay-rate asymmetries of charged bottom mesons and CP violation. PMID- 9957734 TI - Radiative corrections to neutrino indices of refraction. PMID- 9957736 TI - Meson decays by flux-tube breaking. PMID- 9957737 TI - Kobayashi-Maskawa angles and SU(3) breaking in hyperon beta decay. PMID- 9957739 TI - xi (2.2): A Lambda Lambda -bar bound state rather than an orbitally excited quarkonium state. PMID- 9957738 TI - Deuteron electromagnetic form factors in a quark-based model. PMID- 9957740 TI - Analysis of gT(2050-2350) as glueball candidate. PMID- 9957741 TI - Electromagnetic mass differences of 1/2(+) baryons in quark and Skyrme models. PMID- 9957742 TI - On the existence of stable dimesons. PMID- 9957743 TI - Light Dirac neutrino in left-right-symmetric models. PMID- 9957744 TI - Framework for composite vector bosons. II. The unstable-particle case. PMID- 9957745 TI - The vector glueball: An algebraic approach. PMID- 9957746 TI - Properties of the dilaton. PMID- 9957747 TI - Phenomenology of E PMID- 9957748 TI - Quark mass and spin effects in meson wave functions. PMID- 9957749 TI - Hadron-hadron interactions with orthogonal lattice-gauge-field configurations. I. General outlook. PMID- 9957750 TI - Hadron-hadron interactions with orthogonal lattice-gauge-field configurations. II. Nucleon-nucleon system. PMID- 9957751 TI - Numerical study of a confining color-dielectric soliton model. PMID- 9957752 TI - Effective-Lagrangian study of three generations of supersymmetric composite quarks and leptons. PMID- 9957754 TI - Higgs-boson production via bremsstrahlung from heavy quarks. PMID- 9957753 TI - Leading-logarithmic and alpha s corrections to the decay B--> psi X. PMID- 9957756 TI - Quark distribution amplitudes for the nucleon from perturbative QCD and QCD sum rules. PMID- 9957755 TI - Helicity amplitudes of the process J/ psi --> gamma theta in the glueball picture of theta(1700). PMID- 9957757 TI - Comments on "Burning of baryon-rich quark-gluon plasmas" PMID- 9957758 TI - Reply to "Comments on 'Burning of baryon-rich quark-gluon plasmas' " PMID- 9957759 TI - Erratum: 1/N expansion (N=number of generations) and mass hierarchy of charged fermions in composite model for leptons, quarks, and Higgs mesons PMID- 9957761 TI - Supersymmetry signals in leptonic decays of W and Z bosons. PMID- 9957760 TI - Search for magnetically charged particles produced in e+e- annihilations at sqrt s =10.6 GeV. PMID- 9957762 TI - New bound on the anomalous magnetic moment of the W boson. PMID- 9957763 TI - Evolution of the constraint equations in general relativity. PMID- 9957764 TI - Fermions in quantum cosmology. PMID- 9957765 TI - Effect of dynamical friction on the motion of cosmic strings. PMID- 9957766 TI - Evolution of cosmic networks. PMID- 9957768 TI - Fractal geometry of cosmic strings and correlations among galaxies and Abell clusters. PMID- 9957767 TI - Radiation of Goldstone bosons from cosmic strings. PMID- 9957769 TI - Is inflation natural? PMID- 9957771 TI - Can black holes nucleate vacuum phase transitions? PMID- 9957770 TI - Cosmological baryon diffusion and nucleosynthesis. PMID- 9957773 TI - Cartan's contortion as a pair of massless spin-2 fields. PMID- 9957772 TI - Surface geometry of a Kerr-Newman black hole. PMID- 9957774 TI - Inflation in a Bianchi type-I Einstein-Cartan cosmological model. PMID- 9957775 TI - Equation-of-state spinning fluids in the Einstein-Cartan theory. PMID- 9957776 TI - Geometric interpretation of a Yang-Mills theory for gravity. PMID- 9957777 TI - Poincare, de Sitter, and conformal gravity on the lattice. PMID- 9957778 TI - Intermediate-range forces and stellar structure. PMID- 9957779 TI - Anisotropy damping and particle production at finite temperature. PMID- 9957780 TI - Lorentz equations of motion and a theory of connections in a principal bundle. PMID- 9957782 TI - Rayleigh-Schrodinger perturbation theory for the anharmonic oscillator. PMID- 9957781 TI - Geometrical unified theory of connection fields and frame fields. PMID- 9957783 TI - Non-Gaussian multiphoton squeezed states. PMID- 9957784 TI - Squeezed and coherent states of fractional photons. PMID- 9957785 TI - Calculations with supersymmetric potentials. PMID- 9957786 TI - Flat-space singletons. PMID- 9957787 TI - Gauge and gravitational anomalies in two dimensions. PMID- 9957789 TI - Effective generating functions for quantum canonical transformations. PMID- 9957788 TI - Quantum inverse problem for an extended derivative nonlinear Schrodinger system. PMID- 9957791 TI - Covariant equations of motion for the string field and the consistency of the conformal algebra. PMID- 9957790 TI - Radiative generation of a mass term in anti-de Sitter supersymmetry. PMID- 9957792 TI - Covariant string field theory. II. PMID- 9957793 TI - Loop amplitudes in covariant string field theory. PMID- 9957794 TI - Parity violation in type-I superstring graviton exchange. PMID- 9957795 TI - Becchi-Rouet-Stora-Tyutin quantization of superconformal theories. PMID- 9957796 TI - Low-energy effective Lagrangian of heterotic string theory. PMID- 9957797 TI - Adiabatic resonant oscillations of solar neutrinos in three generations. PMID- 9957798 TI - Two-dimensional quantum field theory PMID- 9957799 TI - Instantons with noise. II. Supersymmetric sigma models. PMID- 9957800 TI - Physical look at vacuum fermionic charge. PMID- 9957801 TI - Structure of the perturbative chiral anomaly in the light-cone gauge. PMID- 9957802 TI - Lattice fermions and non-Abelian anomaly. PMID- 9957803 TI - Study of chiral symmetry in lattice QCD at finite temperature and baryon density in the strong-coupling limit. PMID- 9957805 TI - Correlation length and susceptibility near the SU(2) deconfining phase transition. PMID- 9957804 TI - Strong-coupling analysis of the critical dimensionality of space-time in SU(2) lattice gauge theory. PMID- 9957806 TI - Species doubling and transfer matrices for fermionic fields. PMID- 9957807 TI - Localized instanton in four dimensions. PMID- 9957808 TI - Nonperturbative approach to Yang-Mills theories in the continuum. I. Strong coupling confinement. PMID- 9957809 TI - Nonperturbative approach to Yang-Mills theories in the continuum. II. Considerations away from strong coupling. PMID- 9957810 TI - Discretized light-cone quantization: The massless and the massive Schwinger model. PMID- 9957811 TI - Absence of anomaly in the compactified superstring theory in every even dimension. PMID- 9957812 TI - Instability of the static solution to the closed string with rigidity. PMID- 9957813 TI - The D-->- PMID- 9957814 TI - N=2 supersymmetric sigma models and infrared divergences. PMID- 9957815 TI - Possible phase transition of fractional spin in the O(3) sigma model. PMID- 9957816 TI - Renormalized Coulomb-gauge self-energy function. PMID- 9957817 TI - Pseudo-Dirac solar neutrinos? PMID- 9957819 TI - Birkhoff's theorem for electromagnetic fields in a new scalar-tensor theory. PMID- 9957818 TI - Strengths of singularities in Vaidya spacetimes. PMID- 9957820 TI - Erratum: Fierz identities and invariance of 11-dimensional supergravity action PMID- 9957821 TI - Search for charmed mesons produced in hadronic interactions. PMID- 9957823 TI - Incoherent mixing of neutrinos and nu e scattering. PMID- 9957822 TI - Measurement of tau branching ratios. PMID- 9957825 TI - Pion photoproduction and Compton scattering in the cloudy bag model. PMID- 9957824 TI - Structure functions in supersymmetric quantum chromodynamics. PMID- 9957826 TI - Large-pT photon plus opposite-side jet events and the gluon distribution in the nucleon. PMID- 9957827 TI - Two opposite-side large-pT photons in perturbative QCD. PMID- 9957828 TI - Gauginos as a signal for supersymmetry at pp-bar colliders. PMID- 9957829 TI - Transverse-momentum signatures for heavy Higgs bosons. PMID- 9957830 TI - Meson dynamics beyond the quark model: Study of final-state interactions. PMID- 9957832 TI - Spin interactions in the flux-tube model and hybrid meson masses. PMID- 9957831 TI - Zeros in the nucleon form factors and the quark model. PMID- 9957833 TI - Constraint on additional neutral gauge bosons from electroweak radiative corrections. PMID- 9957834 TI - Speculations on fermion mass relationships. PMID- 9957835 TI - Parametrization of the Kobayashi-Maskawa matrix and CP violation. PMID- 9957836 TI - Matrix representation of symmetries in flavor space, invariant functions of mass matrices, and applications. PMID- 9957837 TI - Semiclassical Skyrmion equation of motion. PMID- 9957838 TI - Magnetic moment and form factors of a composite system in a solvable potential model. PMID- 9957839 TI - Examining the P matrix. PMID- 9957840 TI - Analysis and interpretation of a large body of 76Ge zero-neutrino double- beta decay data. PMID- 9957841 TI - Off-diagonal neutral currents. PMID- 9957842 TI - Momentum-transfer dependence of the elastic-amplitude phase in high-energy hadron scattering. PMID- 9957844 TI - On the two-photon-exchange contribution to pi 0-->e+e- gamma. PMID- 9957843 TI - Pseudoscalar decay constants fF and fD from exclusive B decays. PMID- 9957846 TI - Mixing of quark flavors. PMID- 9957845 TI - K0 K-bar 0 transitions in matter. PMID- 9957847 TI - Nonsingular quarkonium potential. PMID- 9957848 TI - Lorentz nature of quark confinement. PMID- 9957849 TI - Erratum: Extra fermions in E6 superstring theories PMID- 9957850 TI - Dynamics of false-vacuum bubbles. PMID- 9957851 TI - Gravity of cosmic loops. PMID- 9957852 TI - Entropy generation in cosmological particle creation and interactions: A statistical subdynamics analysis. PMID- 9957853 TI - Back-reaction calculation of quantum fields in curved spacetime with arbitrary curvature coupling. PMID- 9957855 TI - Vortices in stationary axisymmetric spacetimes. PMID- 9957854 TI - Generalized Kerr-Schild metric for a massless particle on the Reissner-Nordstrom horizon. PMID- 9957856 TI - Observational limits on the time evolution of extra spatial dimensions. PMID- 9957857 TI - Tachyonic compactification. PMID- 9957858 TI - Quantum mechanics of measurements distributed in time. II. Connections among formulations. PMID- 9957860 TI - Nonstandard expansion techniques for the effective potential in lambda phi4 quantum field theory. PMID- 9957859 TI - New approach for calculating the normally ordered form of squeeze operators. PMID- 9957861 TI - Supercurrents and superconformal symmetry. PMID- 9957862 TI - Inverse scattering method and n-step superpotential for axially symmetric, static solutions of sigma models. PMID- 9957865 TI - Topological solitons in gauged nonlinear sigma models. PMID- 9957863 TI - Renormalization and radiative corrections at finite temperature reexamined. PMID- 9957864 TI - Spinor loop anomalies with very general local fermion Lagrangians. PMID- 9957866 TI - Skyrme-model Lagrangian in quantum mechanics: SU(2) case. PMID- 9957867 TI - Parity-violating one-loop six-point function in type-I superstring theory. PMID- 9957868 TI - Strings in curved space-time: Virasoro algebra in the classical and quantum theory. PMID- 9957869 TI - The quasiopen string. PMID- 9957870 TI - Bifurcation of the quark self-energy: Infrared and ultraviolet cutoffs. PMID- 9957871 TI - Application of guided random walks to U(1)2 Hamiltonian lattice gauge theory. PMID- 9957872 TI - Numerical study of the lattice massive Schwinger model using a fast fermion Monte Carlo algorithm. PMID- 9957874 TI - Monte Carlo renormalization-group study of the finite-temperature phase transition in SU(2) gauge theory. PMID- 9957873 TI - Sampling a Gaussian energy distribution to study the phase transitions of the Z(2) and U(1) lattice gauge theories. PMID- 9957875 TI - Quark zero modes and the deconfinement transition in QCD. PMID- 9957876 TI - Goldstone bosons and their superpartners in supersymmetric theories. PMID- 9957879 TI - Dynamical hadronization transition and hydrodynamical stability. II. Mixed phase. PMID- 9957877 TI - Mass splittings in quasi Nambu-Goldstone models. PMID- 9957878 TI - What is the effective potential? PMID- 9957881 TI - Simple coupling with cosmological implications. The initial singularity and the inflationary universe. PMID- 9957880 TI - Parker limit for monopoles with large magnetic charge. PMID- 9957882 TI - Gravitational analogue of the Aharonov-Bohm effect in four and three dimensions. PMID- 9957883 TI - Symmetry and variational methods in higher-dimensional theories: Errata and addendum. PMID- 9957884 TI - Path-integral derivation of conformal anomaly and Casimir effect using dimensional regularization. PMID- 9957885 TI - Orthonormal gauge and affine geometry in string theory. PMID- 9957886 TI - Gauge-invariant objects from Wilson loops. PMID- 9957887 TI - Functional differential equations for gauge theories. PMID- 9957888 TI - Large-N expansion in massless three-dimensional QED. PMID- 9957890 TI - Symmetrical-source method for lattice electromagnetic form factors. PMID- 9957889 TI - Observations on the Nicolai map at finite temperature. PMID- 9957891 TI - Comment on "Anisotropic fluids with multifluid components" PMID- 9957892 TI - Comment on no-go theorems for the minimization of potentials. PMID- 9957893 TI - Four-momentum in classical electrodynamics. PMID- 9957894 TI - Erratum: Time-dependent perturbation theory for quaternionic quantum mechanics, with application to CP nonconservation in K-meson decay PMID- 9957895 TI - Limits on the neutrino lifetime. PMID- 9957897 TI - Gauge-Higgs-fermion spin-spin effects at the Stanford Linear Collider (and CERN LEP). PMID- 9957898 TI - Supersymmetric-particle production at electron-positron colliders. PMID- 9957896 TI - Radiative decays of the J/ psi into gamma pi + pi - and gamma K+K- PMID- 9957900 TI - Contribution of the Delta (1232) to micro-p-->n nu gamma. PMID- 9957899 TI - Creation of relativistic fermionium in collisions of electrons with atoms. PMID- 9957901 TI - Radiation pressure of neutrinos in refracting media. PMID- 9957902 TI - Correlation of pp data with predictions of improved six-quark structure models. PMID- 9957903 TI - Transverse-momentum distribution of dileptons in different scenarios for the QCD phase transition. PMID- 9957905 TI - QCD sum rules and vector-meson masses and widths. PMID- 9957904 TI - Proposed experiment addressing CP and CPT violation in the K0-K-bar0 system. PMID- 9957906 TI - Mass splitting of hadron ground-state multiplets. PMID- 9957907 TI - Solving momentum-space integral equations for quarkonia spectra with confining potentials. II. PMID- 9957909 TI - Neutrino masses and electron-muon- tau -lepton universality. PMID- 9957908 TI - Fourth-generation and exotic quarkonium in E6 theories. PMID- 9957910 TI - Higgs-boson mass bound in E6-based supersymmetric theories. PMID- 9957911 TI - Gaugino masses in superstring models. PMID- 9957912 TI - Quark deconfinement at finite temperature in the bag model. PMID- 9957913 TI - Constraints on bag formation from the scalar sector. PMID- 9957914 TI - Potential and sum-rule approach in QCD. PMID- 9957915 TI - Off-peak lepton asymmetries from new Z's. PMID- 9957916 TI - Scalar neutrinos from rare kaon decay. PMID- 9957917 TI - Predictions of quaternionic quantum mechanics for CP nonconservation in the B and D meson systems. PMID- 9957919 TI - Effects of core motion on the nucleon electric form factors. PMID- 9957918 TI - Perturbative QCD correction to the hard-scattering amplitude for the meson form factor. PMID- 9957921 TI - Erratum: Koba-Nielsen-Olesen scaling, its violation, and the structure of hadrons PMID- 9957920 TI - Comment on the S4-permutation-symmetry model. PMID- 9957922 TI - Measurement of the branching ratio for Upsilon "--> micro micro. PMID- 9957923 TI - Limit on tau decay to seven charged particles. PMID- 9957925 TI - Mass bounds on additional weak bosons in models with fourth-generation fermions. PMID- 9957924 TI - Bottom-quark production at hadron colliders. PMID- 9957926 TI - Two chiral preon models with SU(N) metacolor satisfying complementarity. PMID- 9957927 TI - Gravitational radiation from realistic relativistic stars: Odd-parity fluid perturbations. PMID- 9957928 TI - Strongly trapped points and the cosmic censorship hypothesis. PMID- 9957929 TI - Torsion as a source of expansion in a Bianchi type-I universe in the self consistent Einstein-Cartan theory of a perfect fluid with spin density. PMID- 9957930 TI - Path-integral and operator formalism in quantum gravity. PMID- 9957931 TI - Quantum cosmology and recollapse. PMID- 9957932 TI - How homogeneous was the Universe at the time of a grand-unified-theory phase transition? PMID- 9957933 TI - Cosmological-constant damping by unstable scalar fields. PMID- 9957934 TI - Inflation in spherically symmetric inhomogeneous models. PMID- 9957935 TI - Analytic treatments of matter-enhanced solar-neutrino oscillations. PMID- 9957936 TI - Improved concepts for the discussion of mutually interacting quantum fields in Robertson-Walker universes. PMID- 9957937 TI - Further remarks on particlelike solutions in spinor-connection theory. PMID- 9957938 TI - Expansion for the effective action of an interacting quantum field theory in curved space. PMID- 9957939 TI - Berry's phase in the relativistic theory of spinning particles. PMID- 9957941 TI - Classical adiabatic holonomy and its canonical structure. PMID- 9957940 TI - Classical adiabatic holonomy in a Grassmannian system. PMID- 9957942 TI - O(N)-symmetric lambda phi4 theory: The Gaussian-effective-potential approach. PMID- 9957943 TI - Real-time fermion thermal field theories. PMID- 9957944 TI - Solvable quantum field theories and polynomial conserved quantities for the quantum nonlinear Schrodinger equation. PMID- 9957945 TI - Multichiral free superfields with one central charge for N=2,4,6,8. PMID- 9957946 TI - New algorithm for asymptotic expansions of the heat kernel. PMID- 9957947 TI - Relativistic reduction in momentum space. PMID- 9957948 TI - Fixed-angle asymptotic behavior of the type-I superstring amplitude. PMID- 9957949 TI - Heterotic strings from the bosonic string in 26 dimensions. PMID- 9957950 TI - String theory considered as a local gauge theory of an extended object. PMID- 9957951 TI - Derivation of the gauge-invariant action for open and closed free bosonic string field theories. PMID- 9957952 TI - Gauge invariance of the effective potential. PMID- 9957953 TI - How to distinguish a confining from a deconfining phase in gauge theories with fermions. PMID- 9957956 TI - Thermal Green's functions and transport coefficients on the lattice. PMID- 9957955 TI - Even and odd critical exponents of lattice QED. PMID- 9957954 TI - On the cancellation of anomalies in chiral gauge theories. PMID- 9957958 TI - Hybrid-molecular-dynamics algorithms for the numerical simulation of quantum chromodynamics. PMID- 9957957 TI - Exact implementation of baryon-number conservation in lattice gauge theory. PMID- 9957959 TI - Finite-energy classical solutions to Yang-Mills theories. PMID- 9957960 TI - Conformal anomalies in quantum chromodynamics and the path-integral method. PMID- 9957961 TI - Extended quantum kinematics as an origin of internal symmetries and flavors. PMID- 9957962 TI - Comparison of alternative effective potentials for dynamical symmetry breaking. PMID- 9957963 TI - Chiral-symmetry breaking in finite quantum electrodynamics. PMID- 9957965 TI - Concise way of expressing the physicogeometric content of the gravitational field equations. PMID- 9957964 TI - Electron synchrotron radiation in the far infrared. PMID- 9957966 TI - Some geometrical considerations of Berry's phase. PMID- 9957967 TI - Generalized Holstein-Primakoff squeezed states for SU(n). PMID- 9957968 TI - Compactness criterion for scalar solitons. PMID- 9957969 TI - Bound states in quantum field theory and coherent states: A fresh look. PMID- 9957970 TI - Testing an exact algorithm for simulation of fermionic QCD. PMID- 9957971 TI - Conversion of isospin to spin degrees of freedom: Induced monopole fields in adiabatic processes. PMID- 9957972 TI - Hydrogenlike atom in bosonized QED. PMID- 9957974 TI - Possible cure for difficulties in extended hypercolor models. PMID- 9957973 TI - Study of correlations in fermionic matter. PMID- 9957976 TI - Internal gravity. PMID- 9957975 TI - Erratum: Covariant interacting string field theory in the Fock-space representation PMID- 9957977 TI - Hadron production in e+e- annihilation at sqrt s =29 GeV. PMID- 9957978 TI - Study of eta ' formation in photon-photon collisions. PMID- 9957979 TI - Measurement of p-barp elastic scattering at beam momenta between 390 and 780 MeV/c. PMID- 9957981 TI - Differential cross sections for pi +p and pi -p elastic scattering from 378 to 687 MeV/c. PMID- 9957980 TI - Study of the reaction p PMID- 9957982 TI - Measurement of the nuclear enhancement in high-Et and jet event production. PMID- 9957983 TI - Limit on the mass of the tau neutrino. PMID- 9957984 TI - Laboratory limits on solar axions from an ultralow-background germanium spectrometer. PMID- 9957985 TI - Results from a magnetic-monopole search utilizing He proportional tubes. PMID- 9957986 TI - Delta S=1 chiral Lagrangians revisited. PMID- 9957987 TI - KL--> pi 0e+e- as a probe of CP violation. PMID- 9957988 TI - Horizontal gauge interaction as the primary source of CP violation. PMID- 9957989 TI - Testing O( alpha ) corrections of the electroweak theory: A systematic overview. PMID- 9957990 TI - Baryon octet as SU(3)-subgroup Skyrmions. PMID- 9957991 TI - Momentum projection and relativistic boost of solitons. II. Nucleon and meson properties. PMID- 9957992 TI - Glueball calculations with the t expansion. PMID- 9957993 TI - Neutrino masses in superstring models with E6 singlets coming from H1(End T). PMID- 9957994 TI - Renormalization of the electroweak theory in the nonlinear gauge. PMID- 9957995 TI - Phenomenological potentials for QCD order parameters. PMID- 9957997 TI - Bag formation in the presence of vector mesons. PMID- 9957996 TI - Effects of quark antisymmetrization in a schematic model of the nucleus. PMID- 9957999 TI - Induced logarithmic behavior and spin dependence of the Coulomb plus linear potential. PMID- 9957998 TI - Ginsburg-Landau equation for an interacting quark gas. PMID- 9958000 TI - Tau-neutrino mass limit. PMID- 9958001 TI - Limits on Higgs bosons, scalar-quarkonia, and eta b's from radiative upsilon decays. PMID- 9958002 TI - Photon structure function and optimized perturbation theories. PMID- 9958003 TI - Note on the photoproduction of the charged A1. PMID- 9958004 TI - Production, decays, and forward-backward asymmetries of extra gauge bosons in E6. PMID- 9958005 TI - t-quarkonium decays into bb-bar pairs and charged Higgs bosons. PMID- 9958006 TI - Electric dipole transitions of charmonium D states. PMID- 9958008 TI - Baryogenesis and heavy quarks. PMID- 9958007 TI - Soft-pion S-wave amplitudes and negative-parity baryons in nonleptonic hyperon decays. PMID- 9958009 TI - Comment on "Higgs-boson mass bound in E(6)-based supersymmetric theories" PMID- 9958011 TI - Search for superheavy grand unified magnetic monopoles in cosmic rays. PMID- 9958010 TI - Limit on the decay D0-->e micro+/- PMID- 9958012 TI - Multiplicity distributions in nuclear collisions. PMID- 9958013 TI - Forward charge asymmetry in 20-GeV gammap reactions. PMID- 9958014 TI - Measurement of direct photon production at large transverse momentum in pi -p, pi +p, and pp collisions at 300 GeV/c. PMID- 9958015 TI - Measurement of pi 0 production at large transverse momentum in pi -p, pi +p, and pp collisions at 300 GeV/c. PMID- 9958016 TI - Investigation of the chiral anomaly gamma -->3 pi in pion pair production by pion in the nuclear Coulomb field. PMID- 9958017 TI - Underground search for muons correlated with Cygnus X-3. PMID- 9958018 TI - Search for fractionally charged particles. PMID- 9958020 TI - Spin asymmetries in lepton-hadron scattering. PMID- 9958019 TI - Radiative correction to the equivalent-photon spectrum of a relativistic electron and the two-photon process. PMID- 9958021 TI - Monte Carlo approach to QCD jets in the next-to-leading-logarithmic approximation. PMID- 9958022 TI - Analysis of a quark model with charm and color for inclusive processes. PMID- 9958024 TI - Delayed thresholds and heavy-flavor production in the dual parton model. PMID- 9958023 TI - Detecting gluinos at hadron supercolliders. PMID- 9958025 TI - Flux-tube model for ultrarelativistic heavy-ion collisions: Electrohydrodynamics of a quark-gluon plasma. PMID- 9958026 TI - Comparison of exclusive decay rates for b-->u and b-->c transitions. PMID- 9958027 TI - Analysis of two-body decays of charm mesons using the quark-diagram scheme. PMID- 9958029 TI - Mirror-lepton mixing in tau decays. PMID- 9958028 TI - Chiral anomalies and vector-meson dominance. PMID- 9958031 TI - Mass and wave function of the lightest scalar glueball. PMID- 9958030 TI - Leading-order perturbative QCD calculation of nucleon Dirac form factors. PMID- 9958032 TI - Quark-antiquark spectroscopy and asymptotic freedom. PMID- 9958034 TI - Quark mass matrices and flavor mixing. PMID- 9958033 TI - Towards a general form for the quark mass matrix. PMID- 9958035 TI - U(2)V Yang-Mills approach to Skyrmions with vector mesons: Electromagnetic properties of nucleons. PMID- 9958036 TI - QCD bosonization and the meson effective action. PMID- 9958037 TI - Pions as collective modes in the glueball condensate vacuum. PMID- 9958038 TI - Dynamical pions and kaons in the glueball condensate vacuum. PMID- 9958039 TI - Gluon condensate as ground state of QCD. PMID- 9958041 TI - Simple Higgs mechanisms in the SU(2)LU PMID- 9958040 TI - Long-range dielectric confinement. PMID- 9958043 TI - Particle dichotomy and left-right decomposition of E6 superstring models. PMID- 9958042 TI - Isospin breaking in supersymmetric left-right models. PMID- 9958044 TI - Quantum treatment of beamstrahlung. PMID- 9958045 TI - W-pair production via W-pair fusion. PMID- 9958046 TI - Effective-vector-boson method for high-energy collisions. PMID- 9958048 TI - Electroproduction of hadrons from nuclei. PMID- 9958047 TI - Improved transverse-mass variable for detecting Higgs-boson decays into Z pairs. PMID- 9958049 TI - Radiative neutrino decay in E PMID- 9958050 TI - Precision description of the octet-baryon magnetic moments. PMID- 9958051 TI - Erratum: Analysis of gT(2050-2350) as glueball candidate PMID- 9958052 TI - Observation of electronic excitation by extremely slow protons with applications to the detection of supermassive charged particles. PMID- 9958053 TI - Minimal rephasing-invariant CP-violating parameters with Dirac and Majorana fermions. PMID- 9958054 TI - Supernova 1987A and the secret interactions of neutrinos. PMID- 9958055 TI - Algorithm to search for gravitational radiation from coalescing binaries. PMID- 9958056 TI - Weak resistance in superconducting cosmic strings. PMID- 9958057 TI - "Swiss cheese" models with pressure. PMID- 9958058 TI - Dynamics of bubbles in general relativity. PMID- 9958060 TI - BRST structure of general relativity in terms of new variables. PMID- 9958059 TI - Dynamics of multidimensional generalization of Bianchi type-IX cosmological models. PMID- 9958062 TI - Vacuum state and Schwarzschild solution in ten-dimensional gravity. PMID- 9958061 TI - Adiabatic regularization in closed Robertson-Walker universes. PMID- 9958064 TI - Thermal conduction and gravitational collapse. PMID- 9958063 TI - Particle and string fluid interpretation for the scalar sector of Kaluza-Klein theories. PMID- 9958065 TI - Cauchy data and Hadamard singularities in time-dependent backgrounds. PMID- 9958066 TI - Supersymmetric Volkov-Taub transformation. PMID- 9958067 TI - Two-body Dirac equations for particles interacting through world scalar and vector potentials. PMID- 9958068 TI - Conformal anomaly in spherical spacetimes. PMID- 9958069 TI - Structure of N=2 superconformally invariant unitary "minimal" theories: Operator algebra and correlation functions. PMID- 9958071 TI - Anomalies in Lagrangian field theory. PMID- 9958070 TI - Fujikawa Jacobian, modified symplectic structures, and the anomalous commutators of chiral Abelian gauge theories. PMID- 9958072 TI - Reduction formulas for coherent states. PMID- 9958074 TI - Casimir effect around a cone. PMID- 9958073 TI - Topological defects at finite temperature. PMID- 9958076 TI - Initial-value problems in quantum field theory in the large-N approximation. PMID- 9958075 TI - Static potential for smooth strings in the large-D limit. PMID- 9958078 TI - Renormalization of the Yang-Mills theories in the light-cone gauge. PMID- 9958077 TI - Renormalizability of the time-dependent variational equations in quantum field theory. PMID- 9958079 TI - Supercurrent and the Adler-Bardeen theorem in coupled supersymmetric Yang-Mills theories. PMID- 9958080 TI - Dynamical symmetry breaking and space-time topology. PMID- 9958081 TI - Nonexistence of a ground state and breaking of the no-ghost theorem on a squeezed string. PMID- 9958082 TI - Restudy of the open-superstring tree amplitudes by looking at their field theoretical limits. PMID- 9958083 TI - Dirac-bracket quantization of bosonized chiral two-dimensional QCD. PMID- 9958084 TI - Gauge invariance of the quantum Wilson loop. PMID- 9958086 TI - Monte Carlo study of the multicharged U(1) Higgs model with radial degrees of freedom. PMID- 9958085 TI - Plaquette average and Schwinger-Dyson equation of a Wilson loop in SU(2) lattice gauge theory. PMID- 9958087 TI - Scaling in periodic QED. PMID- 9958088 TI - Perturbative corrections to four-fermion operators on the lattice. PMID- 9958089 TI - Coupled-channel effects in the variational calculation of the glueball mass in lattice Hamiltonian SU(N) gauge theory. PMID- 9958090 TI - Comparison of two gauge-nonequivalent IAnsaItzeB for charged vortices in SU(2) gauge theory with Chern-Simons term. PMID- 9958091 TI - Absence of spontaneous parity violations in three-dimensional QED induced by infrared effects. PMID- 9958093 TI - Variational calculations on bound states of quantum systems motivated by the t expansion method. PMID- 9958092 TI - Conditions for absence of global SU(2) anomaly for four-dimensional gauge groups. PMID- 9958094 TI - Tests of relativity from SN1987A. PMID- 9958095 TI - Stellar energy loss and anomalous contributions to gamma gamma --> nu nu -bar. PMID- 9958097 TI - Comment on "Unified dynamics for microscopic and macroscopic systems" PMID- 9958096 TI - Bosonic strings in an arbitrary dimension. PMID- 9958098 TI - Disentanglement of quantum wave functions: Answer to "Comment on 'Unified dynamics for microscopic and macroscopic systems' " PMID- 9958100 TI - Chiral-symmetry order parameter, the lattice, and nucleosynthesis. PMID- 9958099 TI - Erratum: Test-particle motion in the nonsymmetric gravitation theory PMID- 9958102 TI - Space structure of confining strings. PMID- 9958101 TI - Non-Abelian gauge fields in two spatial dimensions. PMID- 9958103 TI - Limits on nu micro--> nu tau and nu micro--> nu e oscillations. PMID- 9958104 TI - Search for narrow states by detection of monochromatic gamma rays in p-barp annihilation at rest. PMID- 9958106 TI - Four-momentum transfer between fireballs in proton-nucleus interactions at 400 GeV. PMID- 9958105 TI - High-energy diffraction dissociation of KL0 into exclusive final states. PMID- 9958109 TI - Unpolarized and polarized structure functions and spin tests at supercollider energies. PMID- 9958107 TI - Search for magnetic monopoles trapped in old iron ores using a superconducting detector. PMID- 9958108 TI - Leptoquark-boson signals at e+e- colliders. PMID- 9958110 TI - Photon pair production in expanding hot hadronic matter. PMID- 9958111 TI - Limits on leptonic right-handed currents in E6 theories. PMID- 9958113 TI - Relativistic formulation of the radiative transitions of charmonium and b quarkonium. PMID- 9958112 TI - Formulation of two-photon and two-gluon decays of pseudoscalar eta mesons in a relativistic bound-state calculation. PMID- 9958114 TI - Phenomenological model for psi -->T gamma decays. PMID- 9958115 TI - Fourth generation and nucleon decay in supersymmetric theories. PMID- 9958116 TI - Heavy-Z-boson decays to two bosons in E6 superstring models. PMID- 9958117 TI - Accurate baryon masses from meson masses using potential models and the 1/D expansion. PMID- 9958118 TI - Neutron-proton mass difference in the chiral solitonic bag model. PMID- 9958120 TI - Strongly interacting singlet-doublet Higgs model. PMID- 9958119 TI - Spin splittings of heavy-quark bound states from lattice QCD. PMID- 9958121 TI - Yukawa couplings and phenomenology of a three-generation superstring model. PMID- 9958122 TI - Horizontal symmetry and the fourth generation. PMID- 9958123 TI - Resonance determination by stabilized analytic continuation of theoretical data, and comparison with the moments method. PMID- 9958124 TI - Limit on the radiative width of the K0(1430). PMID- 9958126 TI - Coupled-channel treatment of Cabibbo-angle-suppressed (D,Ds+)-->PP decays. PMID- 9958127 TI - Consequences of nonzero neutrino masses on the evaluation of the weak coupling constant and on tau leptonic decays. PMID- 9958125 TI - Exclusive production of proton-antiproton pairs in two-photon collisions. PMID- 9958128 TI - Addendum to " Delta S=1 chiral Lagrangians revisited" PMID- 9958129 TI - H dibaryon in the naive quark model with arbitrary Nc. PMID- 9958130 TI - SU(3)-flavor-symmetry breaking in c-barsuud bound states. PMID- 9958131 TI - Variational scalar and tensor lattice glueball masses. PMID- 9958132 TI - Erratum: Rotational bands in the baryon spectrum. II PMID- 9958134 TI - Erratum: Mirror-lepton mixing in tau decays PMID- 9958133 TI - Erratum: Baryon self-energy due to the pion-quark interaction PMID- 9958135 TI - Analyzing power for pi -p charge exchange and a test of isospin invariance up to eta threshold. PMID- 9958136 TI - Search for free quarks produced by 14.5-GeV/nucleon oxygen ions. PMID- 9958137 TI - Search for high-energy muons from Cygnus X-3 during the radio outbursts in 1983 and 1985. PMID- 9958139 TI - Optimal design of resonant-mass gravitational wave antennas. PMID- 9958138 TI - Violation of flavor universality from superstring quark-singlet production. PMID- 9958141 TI - Gravitational collapse of massless scalar field and cosmic censorship. PMID- 9958140 TI - Prospects for a day-night 37Cl solar-neutrino oscillation experiment. PMID- 9958143 TI - Cosmological model of the Kaluza-Klein type. PMID- 9958142 TI - A fluid of multidimensional objects. PMID- 9958144 TI - Stability of flat spacetime in quantum gravity. PMID- 9958145 TI - Expectation values in quantum cosmology. PMID- 9958146 TI - Density of states for the gravitational field in black-hole topologies. PMID- 9958147 TI - Correlations in the wave function of the Universe. PMID- 9958148 TI - The factor-ordering problem must be regulated. PMID- 9958149 TI - Perdurance of higher-dimensional de Sitter space. PMID- 9958150 TI - Coupled field solutions for U(1)-gauge cosmic strings. PMID- 9958151 TI - Exact axially symmetric stationary solutions of the Kaluza-Klein-Jordan-Thiry theory. PMID- 9958152 TI - Phenomenological aspects of new gravitational forces. I. Rapidly rotating compact objects. PMID- 9958153 TI - Phenomenological aspects of new gravitational forces. II. Static planetary potentials. PMID- 9958154 TI - Phenomenological aspects of new gravitational forces. III. Slowly rotating astronomical bodies. PMID- 9958155 TI - Zero-point field in a circular-motion frame. II. Spinor and vector fields. PMID- 9958156 TI - Exact solutions of the Dirac equation in spatially flat Robertson-Walker space times. PMID- 9958157 TI - Casimir energies in M4 >= N for even N. Green's-function and zeta-function techniques. PMID- 9958158 TI - Connection of some two-dimensional bosonic and fermionic models to scalar curvature. PMID- 9958160 TI - Lie-algebra cohomology and the Osp(1,1||2) structure in string theory. PMID- 9958159 TI - Derivative expansion and the induced Chern-Simons term at finite temperature in 2+1 dimensions. PMID- 9958161 TI - Vacuum averages for arbitrary spin around a cosmic string. PMID- 9958162 TI - Operatorial Chan-Paton factors. PMID- 9958164 TI - Induced angular momentum and gauge invariance. PMID- 9958163 TI - Is the nonlinear sigma model the m sigma --> PMID- 9958166 TI - Fermions in the chiral Schwinger model. PMID- 9958165 TI - Gauge theories in three-dimensional space-time. PMID- 9958167 TI - Variational methods in supersymmetric lattice field theory: The vacuum sector. PMID- 9958169 TI - Compact three-dimensional U(1) gauge theory reexamined. PMID- 9958168 TI - Empirical study of the hybrid-molecular-dynamics approach to the simulation of QCD. PMID- 9958171 TI - Long-distance Lienard-Wiechert potentials and qq-bar spin dependence. PMID- 9958170 TI - Complete bosonization of two-dimensional QCD in the path-integral framework. PMID- 9958172 TI - Reexamination of astrophysical and cosmological constraints on the magnetic moment of neutrinos. PMID- 9958173 TI - Erratum: How reliable are neutrino mass limits derived from SN1987A: PMID- 9958174 TI - Light neutral boson in spinor-connection theory. PMID- 9958176 TI - Erratum: Renormalization versus the Gaussian effective potential PMID- 9958175 TI - Numerical studies of the Faddeev-Popov determinant for different SU(n) groups. PMID- 9958177 TI - (Super)Korteveg-de Vries equation as a (super)conformal field theory. PMID- 9958178 TI - Strong-field point-particle limit and the equations of motion in the binary pulsar. PMID- 9958179 TI - Energy loss in general relativity. PMID- 9958181 TI - Supersymmetric cosmic accelerators: Fluxes at Earth and companion stability. PMID- 9958180 TI - Peculiar velocities from cosmic strings. PMID- 9958182 TI - Stephenson-Kilmister-Yang theory of gravity and its dynamics. PMID- 9958183 TI - Analysis of no-scale supergravity models leading to inflationary scenarios. PMID- 9958184 TI - Improved nullification of gravity gradients. PMID- 9958185 TI - Higher-derivative gravity, surface terms, and string theory. PMID- 9958187 TI - Light-fermion-mass generation in a Kaluza-Klein theory. PMID- 9958186 TI - Higher-dimensional self-consistent solution with deformed internal space. PMID- 9958188 TI - Soliton-radiation interaction in nonlinear integrable lattices. PMID- 9958189 TI - BRST-invariant transitions between closed and open strings. PMID- 9958190 TI - Becchi-Rouet-Stora-Tyutin quantization of twisted extended fermionic strings. PMID- 9958192 TI - Factorization and zero-slope limit of strings. PMID- 9958191 TI - A parametrization of the covariant superstring. PMID- 9958193 TI - Construction of multiloop superstring amplitudes in the light-cone gauge. PMID- 9958194 TI - Stochastic quantization of Yang-Mills field theory: Gauge-fixing parameter dependence and equilibrium limit. PMID- 9958196 TI - Entropy of the SU(2) lattice gauge field. PMID- 9958195 TI - Overrelaxation and Monte Carlo simulation. PMID- 9958198 TI - Simple numerical approach to quantum lattice models. PMID- 9958197 TI - U(1) problem and topological excitations on a lattice. PMID- 9958199 TI - Non-Abelian bosonization: Stress-energy correlation functions. PMID- 9958200 TI - Critical surfaces and flat directions in a finite theory. PMID- 9958201 TI - Chiral hierarchies from slowly running couplings in technicolor theories. PMID- 9958203 TI - One-loop corrections to solitons in two-dimensional theories. PMID- 9958202 TI - Sphalerons, small fluctuations, and baryon-number violation in electroweak theory. PMID- 9958204 TI - Effective Hamiltonians for generalized Breit interactions in QCD. PMID- 9958206 TI - Gravitational acceleration of relativistic particles at finite temperature. PMID- 9958205 TI - Conformal transformation of the one-loop effective action for lambda phi4 theory. PMID- 9958207 TI - Heat-kernel expansion on a polyhedron. PMID- 9958208 TI - Derivative expansion and the chiral anomaly at finite temperature. PMID- 9958209 TI - Solitons in the supersymmetric CPN-1 model. PMID- 9958210 TI - Dyon solutions in the temporal gauge. PMID- 9958212 TI - Proposed atomic cascade experimental test of symmetric local hidden-variables theories. PMID- 9958211 TI - SU(3)-multiplet sources at the phase transition to the quark-gluon plasma. PMID- 9958213 TI - Anomalies in conservation laws in quantum mechanics. PMID- 9958214 TI - Observations on path-integral derivations of anomalies. PMID- 9958215 TI - Comment on a possible supersymmetrization of a new class of gauge theory. PMID- 9958216 TI - Comment on "1/N expansion for a Mie-type potential" PMID- 9958217 TI - Erratum: Propagation properties and condensate formation of the confined Yang Mills field PMID- 9958218 TI - Soliton-antisoliton pair creation in strong external fields. PMID- 9958219 TI - Measurement of antineutron-proton total and annihilation cross sections from 100 to 500 MeV/c. PMID- 9958220 TI - Measurement of the ratio of Sigma 0 to Lambda 0 inclusive production from 28.5 GeV/c protons on beryllium. PMID- 9958221 TI - Measurement of the tau lifetime. PMID- 9958223 TI - Search for a Bhabha-scattering resonance near 1.8 MeV/c2. PMID- 9958222 TI - Comparison of narrow-band and wide-band neutrino beams in the search for nu micro -> nu e oscillations. PMID- 9958224 TI - e+e--->W+W- in E PMID- 9958225 TI - Extra Z's from E6 and other exotic physics in heavy-quarkonium decays. PMID- 9958226 TI - Light scalar top quark at e+e- colliders. PMID- 9958228 TI - Extraction of higher-twist contribution from large-PT pion photoproduction processes. PMID- 9958227 TI - Predicted properties of Delbruck scattering for photon energies up to 104 MeV. PMID- 9958229 TI - Testing the effect of higher-twist subprocess in p-bar-p and p-p collisions. PMID- 9958231 TI - Branching, geometrical scaling, and Koba-Nielsen-Olesen scaling. PMID- 9958230 TI - Multiplicity distributions in pp-bar collisions at 540 GeV and "bremsstrahlung analogy" PMID- 9958232 TI - Vector-boson production in supersymmetric QCD. PMID- 9958233 TI - Possibility of simultaneous observation of nucleus fragment and gamma -ray family in the stratosphere. PMID- 9958234 TI - CP violation in K-->3 pi. PMID- 9958235 TI - Subleading QCD corrections to the K-K-bar system. PMID- 9958236 TI - Charge-commutation-relation approach to the Cabibbo angle and meson masses in SU(2)LU PMID- 9958237 TI - Decoupling of the pion at finite temperature and density. PMID- 9958238 TI - Langevin simulation of the full QCD hadron mass spectrum on a lattice. PMID- 9958239 TI - Anomalous magnetic and quadrupole moments of the W boson in the two-Higgs-doublet model. PMID- 9958241 TI - New supersymmetric left-right gauge model: Higgs-boson structure and neutral current analysis. PMID- 9958240 TI - Cancellation of the divergence of the wave function at the origin in leptonic decay rates. PMID- 9958243 TI - Coherent-state representation for the QCD ground state. PMID- 9958242 TI - Systematic analysis of Hermitian quark mass matrices. PMID- 9958244 TI - Hamiltonian lattice string theory and the flux-tube model. PMID- 9958245 TI - Density of states in the quantum-chromodynamic bag model with a nonzero baryon number. PMID- 9958246 TI - Structure of hydrodynamic flows in expanding quark-gluon plasmas. PMID- 9958248 TI - Dynamical model for composite quarks and leptons based on supersymmetric quantum chromodynamics. PMID- 9958247 TI - Phenomenological clues for discrete symmetries in superstring theories. PMID- 9958249 TI - Renormalization-group-improved Yennie-Frautschi-Suura theory. PMID- 9958250 TI - Scalar interaction in tau decay. PMID- 9958251 TI - B0-->D0+ gamma decay as a probe for short-distance QCD corrections. PMID- 9958252 TI - Understanding the Feynman-x distribution of charm D mesons produced in hadronic collisions. PMID- 9958253 TI - Axion creation in high-energy scattering of electrons on atoms. PMID- 9958254 TI - Anomaly-free version of SU(2)U PMID- 9958255 TI - Symmetry-breaking hierarchies in the Pati-Salam group induced by supergravity. PMID- 9958256 TI - Comments on the Z electromagnetic couplings in a composite model. PMID- 9958257 TI - Erratum: Detection rates for "invisible"-axion searches PMID- 9958258 TI - || Delta I||=(1/2 rule and consequences for D and B decays and epsilon '/ epsilon. PMID- 9958259 TI - Use of Z lepton asymmetry to determine mixing between Z boson and Z' boson of E6 superstrings. PMID- 9958260 TI - Fragmentation of cosmic string loops. PMID- 9958261 TI - Numerical simulation of cosmic-string evolution in flat spacetime. PMID- 9958263 TI - Cosmic balls of trapped neutrinos. PMID- 9958262 TI - Cosmic texture and the microwave background. PMID- 9958264 TI - Ultra-high-energy cosmic rays from superconducting cosmic strings. PMID- 9958265 TI - Strings and other distributional sources in general relativity. PMID- 9958266 TI - Singularities in Kaluza-Klein-Friedmann cosmological models. PMID- 9958267 TI - Boundary conditions and the cosmological constant. PMID- 9958268 TI - Positivity of total energy in general relativity. PMID- 9958269 TI - Local and global gravitomagnetic effects in Kerr spacetime. PMID- 9958270 TI - Colliding plane gravitational waves: A class of nondiagonal soliton solutions. PMID- 9958271 TI - Origin of Hawking radiation. PMID- 9958272 TI - Energy transport and evaporation of weakly interacting particles in the Sun. PMID- 9958273 TI - Decay of the true vacuum in curved space-time. PMID- 9958274 TI - Spinors on a tetrahedron. PMID- 9958275 TI - Mixed procedures for generating families of isospectral Hamiltonians. PMID- 9958277 TI - OSp(N,4)-invariant dimensional regularization. PMID- 9958276 TI - Cohomology and heterotic world-sheet anomalies. PMID- 9958279 TI - Solving two-dimensional phi4 theory by discretized light-front quantization. PMID- 9958278 TI - Grassmann-valued processes for the Weyl and the Dirac equations. PMID- 9958280 TI - Path-integral formulation of closed strings. PMID- 9958281 TI - Nonassociative formulation of bosonic strings. PMID- 9958282 TI - Superstrings at finite temperature. PMID- 9958283 TI - Modular invariance of the thermo-partition function and global phase structure of the heterotic string. PMID- 9958284 TI - New symmetry in covariant open-string field theory. PMID- 9958285 TI - Continuum regularization of superfield supersymmetry: Super QED. PMID- 9958286 TI - Conformal extension of gauge theories with spontaneously broken symmetry. PMID- 9958287 TI - Complex actions for fermions in higher dimensions. PMID- 9958289 TI - N-quantum calculation of the Nambu-Jona-Lasinio model with isospin. PMID- 9958288 TI - Instability of the translationally invariant vacuum of a system of fermions coupled to a chiral field. PMID- 9958290 TI - Color-dielectric parameter in (2+1)-dimensional QCD. PMID- 9958291 TI - Gravitational acceleration of antiprotons and of positrons. PMID- 9958293 TI - Green's function for the scalar field in the early Universe. PMID- 9958292 TI - On a stationary asymptotically flat solution of the Ernst equation. PMID- 9958294 TI - Expansion of the early Universe and the equation of state. PMID- 9958296 TI - Series solutions for the Klein-Gordon equation in Schwarzschild space-time. PMID- 9958295 TI - Solar-neutrino oscillations from a supersymmetric E6 grand unified theory. PMID- 9958297 TI - Accurate energy levels and partition function of a quantum-mechanical anharmonic oscillator. PMID- 9958298 TI - Comment on Jourjine's space-time Dirac-Kahler spinors and string model. PMID- 9958299 TI - Comment on "Coherent states for the time-dependent harmonic oscillator" PMID- 9958300 TI - Erratum: Lattice fermions in the Schwinger model PMID- 9958301 TI - Ambiguities in the Thirring model under chiral rotations. PMID- 9958303 TI - Production of neutral strange particles KS0 PMID- 9958302 TI - Exclusive decays and masses of the B mesons. PMID- 9958305 TI - e+e---> tau + micro- due to scalar-lepton mixing. PMID- 9958304 TI - Final-photon polarization in the scattering of photons by high-energy electrons. PMID- 9958306 TI - Extra neutral gauge bosons in electron-positron collisions at resonance. PMID- 9958307 TI - Deep-inelastic structure functions in the MIT bag model. PMID- 9958308 TI - Hadron cross sections at ultrahigh energies and unitarity bounds on diffraction. PMID- 9958310 TI - Higgs-boson signals in superstring-inspired models at hadron supercolliders. PMID- 9958309 TI - Looking for spin-(3/2 leptons in hadronic collisions. PMID- 9958311 TI - Angular distributions of secondary charged particles in showers initiated by gammas and protons. PMID- 9958312 TI - Electromagnetic-shower development in concrete and the punchthrough effect. PMID- 9958313 TI - Comprehensive analysis of data pertaining to the weak neutral current and the intermediate-vector-boson masses. PMID- 9958314 TI - Neutrino masses, Majorons, and muon decay. PMID- 9958315 TI - K--> pi pi gamma in the six-quark model. PMID- 9958316 TI - D and E mesons, and related problems. PMID- 9958317 TI - Production, decay, and mixing models of the iota meson. II. PMID- 9958318 TI - Determination of the Lambda magnetic moment by QCD sum rules. PMID- 9958320 TI - Systematic examination of spin-independent and spin-dependent interactions of heavy quarks. PMID- 9958319 TI - Gluon-field contribution in QCD sum rules for the magnetic moments of the nucleons. PMID- 9958321 TI - Relativistic description of quarkonium. PMID- 9958322 TI - See-saw masses for quarks and leptons. PMID- 9958323 TI - Strongly coupled quarks in the standard model. PMID- 9958325 TI - New solutions of QCD as models for hadrons and rings of confined gluons. PMID- 9958324 TI - Low-energy theorems for strongly interacting W's and Z's. PMID- 9958327 TI - Implications of the E6SU PMID- 9958326 TI - Velocity of sound in hadron matter. PMID- 9958328 TI - Interaction of relativistic elementary atoms with matter. I. General formulas. PMID- 9958329 TI - Interaction of relativistic elementary atoms with matter. II. Numerical results. PMID- 9958330 TI - Nonlinear saturation of the longitudinal modes of the coasting beam in a storage ring. PMID- 9958331 TI - Light-boson emission in the decay of the micro+ PMID- 9958332 TI - Top-quark mass determination in hadron colliders. PMID- 9958333 TI - Comments on the relation between the mass of Upsilon (1(1)P1) and the QCD scale parameter Lambda MS PMID- 9958334 TI - Update on the determination of baryon magnetic moments by the QCD sum-rule method. PMID- 9958335 TI - Light-cone description of pionic corrections to nucleon electromagnetic properties. PMID- 9958336 TI - Comments on "Introduction to the chemistry of fractionally charged atoms: Electronegativity" PMID- 9958337 TI - Merit of ground-state electronegativities; a reply to "Comments on 'Introduction to the chemistry of fractionally charged atoms: Electronegativity' " PMID- 9958338 TI - Gluon production of gauge bosons. PMID- 9958339 TI - Comparison of bar and interferometer sensitivities to sources of transient gravitational radiation. PMID- 9958340 TI - New Hamiltonian formulation of general relativity. PMID- 9958341 TI - Can bulk viscosity drive inflation? PMID- 9958342 TI - Probability of R2 inflation. PMID- 9958343 TI - Exact analytic solutions for Mikheyev-Smirnov-Wolfenstein level crossings. PMID- 9958344 TI - Global properties of Kaluza-Klein cosmologies. PMID- 9958345 TI - Tabulation of astrophysical constraints on axions and Nambu-Goldstone bosons. PMID- 9958346 TI - Mass limits on particles from pulsed sources: How reliable are they? PMID- 9958348 TI - Causal boundary of space-times. PMID- 9958347 TI - Instability of Killing-Cauchy horizons in plane-symmetric spacetimes. PMID- 9958350 TI - Constraint algebra in Poincare gauge theory. PMID- 9958349 TI - Traceless pole particles with intrinsic spin in spaces with torsion. PMID- 9958351 TI - Helicity in anti-de Sitter space. PMID- 9958352 TI - Attempt at a classical cancellation of the cosmological constant. PMID- 9958353 TI - Symmetry behavior in curved spacetime: Finite-size effect and dimensional reduction. PMID- 9958354 TI - Geometrical properties of an internal local octonionic space in curved space time. PMID- 9958355 TI - Variational principles for conservative and dissipative diffusions. PMID- 9958357 TI - Yang-Mills equations and solvable groups. PMID- 9958356 TI - Vacuum state of complex scalar fields in SO(2,1)-invariant backgrounds. PMID- 9958358 TI - Renormalization versus the Gaussian effective potential. PMID- 9958359 TI - Classical field configurations and infrared slavery. PMID- 9958361 TI - World-sheet topology and target manifold in string theory. PMID- 9958360 TI - Particles, superparticles, and twistors. PMID- 9958362 TI - String field theory at finite temperature. PMID- 9958363 TI - Gauge symmetries in (super)string field theory. PMID- 9958364 TI - String-ghost interactions and the trace anomaly. PMID- 9958365 TI - String amplitudes as solutions to soliton equations. PMID- 9958366 TI - Interacting quasiopen strings. PMID- 9958367 TI - Quantum electrodynamics in the temporal gauge. PMID- 9958368 TI - Yang-Mills theory and quantum chromodynamics in the temporal gauge. PMID- 9958370 TI - Unifying temporal, Coulomb, and relativistic gauges. PMID- 9958369 TI - Spacelike axial-gauge Feynman rules: A consistent nonambiguous derivation. PMID- 9958372 TI - theta -term effect on the charge spectra of dyons associated with generalized magnetic monopoles and quarks as dyons in a spontaneously broken gauge theory. PMID- 9958371 TI - Monte Carlo simulations and complex actions. PMID- 9958373 TI - Some global charges in classical Yang-Mills theory. PMID- 9958375 TI - Wilson loops in bosonized two-dimensional QCD. PMID- 9958374 TI - Time-dependent Hartree-Fock formalism and the excitations of the Dirac sea in the Nambu-Jona-Lasinio model. PMID- 9958377 TI - Numerical tests of Langevin lattice QCD. PMID- 9958376 TI - Application of the real-time temperature Green's functions to chiral-symmetry breaking and restoration. PMID- 9958379 TI - Feynman rules of Coulomb-gauge QED and the electron magnetic moment. PMID- 9958378 TI - Hartree approximation to QCD in the Fock-Schwinger gauge. PMID- 9958380 TI - Double-bubble spacetimes. PMID- 9958381 TI - Holonomy transformation, deficit angle, and Aharonov-Bohm effect in a cylindrically symmetric universe. PMID- 9958382 TI - Quantized non-Abelian monopole. PMID- 9958383 TI - Two-loop renormalization of the Pontryagin density in pure Yang-Mills theory. PMID- 9958384 TI - Comparison between the body-centered hypercubic and simplicial lattices. PMID- 9958385 TI - Measurability of the Casimir effect in microchips. PMID- 9958386 TI - Relation between triangular- and Witten-SU(2)-anomaly cancellation for gauge groups. PMID- 9958387 TI - Rho and omega production in pi+p interactions at 15.7 GeV/c. PMID- 9958389 TI - Search for fractional charges using droplet-jet techniques. PMID- 9958388 TI - Measurement of the polarization of tau leptons produced in e+e- annihilation at sqrt s =29 GeV. PMID- 9958390 TI - Monopole-flux and proton-decay limits from the Soudan 1 detector. PMID- 9958391 TI - Hadronic contributions to the photon structure function. PMID- 9958392 TI - Multisource model for particle production in high-energy hadron-nucleus collisions. PMID- 9958393 TI - A multiple-interaction model for the event structure in hadron collisions. PMID- 9958394 TI - Production of new charged leptons decaying into massive neutrinos. PMID- 9958395 TI - On estimating mean lifetimes by a weighted sum of lifetime measurements. PMID- 9958396 TI - Determination of the A parameter in supergravity models from Z0--> two gluinos. PMID- 9958397 TI - Penguin matrix elements in chiral perturbation theory and in vacuum insertion. PMID- 9958399 TI - Determining probabilities and momentum fractions from distribution amplitudes. PMID- 9958398 TI - Perturbative QCD and electromagnetic form factors. PMID- 9958401 TI - H-dibaryon spectroscopy. PMID- 9958402 TI - H-particle stability in the nonrelativistic quark model. PMID- 9958400 TI - Radiative-decay systematics and flavor-symmetry breaking from heavy quarks. PMID- 9958403 TI - Model for the dynamical generation of lepton, quark, and intermediate-boson masses. PMID- 9958404 TI - Phenomenology of composite technicolor standard models. PMID- 9958405 TI - Rephasing-invariant parametrizations of generalized Kobayashi-Maskawa matrices. PMID- 9958406 TI - Fritzsch mass matrix with the fourth generation and the renormalization-group equations. PMID- 9958407 TI - Flavor projection operators and applications to CP violation with any number of families. PMID- 9958408 TI - Quark-gluon plasma at finite baryon density: A large-Nc approach. PMID- 9958409 TI - Nontopological solitons in strongly coupled QED. PMID- 9958411 TI - New limits from single-photon searches at e+e- colliders. PMID- 9958410 TI - Comparison between the coherent-pair approximation and projection from a hedgehog Fock state in chiral soliton models. PMID- 9958413 TI - Calculations of standard-Higgs-boson production cross sections in e+e- collisions by means of a reasonable set of parameters. PMID- 9958412 TI - Signatures of vector-boson compositeness in e+e---> micro+ micro- for the strongly coupled standard model. PMID- 9958414 TI - Sufficiency of double correlations in polarization analyses. PMID- 9958415 TI - Isoscalar axial-vector form factor at high Q2. PMID- 9958416 TI - Kinetic coefficients for quark-antiquark plasma with quantum treatment of color. PMID- 9958417 TI - A peculiar relation between mass and energy with respect to the Schrodinger equation. PMID- 9958418 TI - Comment on "Muon polarization in KL0--> micro micro-bar decay as a test of CP violation models" PMID- 9958419 TI - Comments on the electron anomalous magnetic moment between conducting plates. PMID- 9958421 TI - Effective-Lagrangian calculation of the pi pi eta decay mode of the tau lepton. PMID- 9958422 TI - Implications of a precise Z-boson mass determination. PMID- 9958420 TI - Upper limit on B( tau --> eta pi nu ). PMID- 9958424 TI - Bounds on hadronic axions from stellar evolution. PMID- 9958423 TI - Axions and stars. PMID- 9958425 TI - Average energy density and the size of the Universe. PMID- 9958426 TI - Radiation from kinky, cuspless cosmic loops. PMID- 9958427 TI - Dissipationless clustering of neutrinos around a cosmic-string loop. PMID- 9958428 TI - Cosmic strings and Einstein-Rosen soliton waves. PMID- 9958429 TI - Gravitational wave pulse and soliton wave collision. PMID- 9958431 TI - Treatment of neutrino oscillations in a thermal environment. PMID- 9958430 TI - Fermion masses on the vortex world sheet. PMID- 9958432 TI - Magnetic moments of neutrinos: Particle and astrophysical aspects. PMID- 9958433 TI - Nuclear response of water Cherenkov detectors to supernova and solar neutrinos. PMID- 9958434 TI - Nonadiabatic level crossing in neutrino oscillations for an exponential solar density profile. PMID- 9958435 TI - Hamiltonian lattice gravity. Deformations of discrete manifolds. PMID- 9958437 TI - Scalar-tensor theory in higher-dimensional space-time with torsion. PMID- 9958436 TI - Gravitational radiation damping in systems with compact components. PMID- 9958438 TI - Experimental tests on unified theories of the scalar-vector-tensor type. PMID- 9958439 TI - Experimental test of the law of gravitation at small distances. PMID- 9958441 TI - Lifetime of a black hole. PMID- 9958440 TI - Reflections on moving mirrors. PMID- 9958442 TI - Conformal rotation in perturbative gravity. PMID- 9958443 TI - Conservation of probability and quantum cosmological singularities. PMID- 9958444 TI - Cosmological consequences of gravitationally interacting Planck-mass particles. PMID- 9958446 TI - Explicit illustration of causality violation: Noncausal relativistic wave-packet evolution. PMID- 9958445 TI - Quantum gravity: Observational constraints on a pair of Yukawa terms. PMID- 9958447 TI - Hamiltonian formalism for path-dependent Lagrangians. PMID- 9958449 TI - Abelian bosonization in curved space. PMID- 9958448 TI - Squeezing versus photon-number fluctuations. PMID- 9958450 TI - phi4 theory in 1+d dimensions at high temperature: Dimensional reduction. PMID- 9958452 TI - Stability of nonlinear spinor fields with application to the Gross-Neveu model. PMID- 9958451 TI - Nonstandard expansion techniques for the finite-temperature effective potential in lambda phi4 quantum field theory. PMID- 9958453 TI - Vacuum energy of M4 >= M >= N in even dimensions. PMID- 9958454 TI - Tensor and bispinor representation of massless fields. PMID- 9958455 TI - Relationship between supersymmetry and solvable potentials. PMID- 9958456 TI - Understanding complex perturbative effective potentials. PMID- 9958457 TI - Becchi-Rouet-Stora analysis of the bosonized chiral Schwinger model. PMID- 9958459 TI - Bound-state problem in quantum field theory: Linear and nonlinear dynamics. PMID- 9958458 TI - Systematic search for anomaly-free theories. PMID- 9958460 TI - Yang-Mills self-energy in a class of linear gauges. PMID- 9958461 TI - Absence of topological effects in the gauged SU(2) nonlinear sigma model in 2+1 dimensions. PMID- 9958462 TI - Bifurcation in the Yang-Mills field equations with static sources. PMID- 9958463 TI - Global gauge transformations and conserved, gauge-invariant electric and magnetic charges in Yang-Mills gauge theories. PMID- 9958464 TI - Chiral anomaly for the Dirac operator in an instanton background via the Atiyah Patodi-Singer theorem. PMID- 9958465 TI - Continuum limit of lattice gauge theory: A perturbative study. PMID- 9958466 TI - SU(2) lattice gauge theory and the convergence of the t expansion. PMID- 9958468 TI - Properties of some self-dual monopoles. PMID- 9958467 TI - Universality and the Lambda parameter on a body-centered hypercubic lattice. PMID- 9958469 TI - Multibody quark forces in quantum chromodynamics. PMID- 9958470 TI - Two-loop modular invariance and proper spin-statistics projection for general boundary conditions. PMID- 9958471 TI - New constraints and residual symmetry breaking in fine strings. PMID- 9958473 TI - Derivative expansion and the solubility of two-dimensional models. PMID- 9958472 TI - Improved model of bosonic string. PMID- 9958475 TI - Real-time finite-temperature evolution equation for the Higgs field in an expanding universe. PMID- 9958474 TI - Power corrections from nonlocal terms in a Lagrangian. PMID- 9958476 TI - Finite-temperature and -density effects on electron self-mass and primordial nucleosynthesis. PMID- 9958477 TI - Functional integral for Weyl fermions and the effective action. PMID- 9958478 TI - Search for direct gamma production at low transverse momentum in 63-GeV pp collisions. PMID- 9958479 TI - Search for admixtures of massive neutrinos in the decay pi +--> micro++ nu. PMID- 9958481 TI - Search for grand unification monopoles and other ionizing heavy particles using a scintillation detector at the Earth's surface. PMID- 9958480 TI - Measurement of the properties of the eta ' and search for other resonances in gamma gamma --> eta pi 0 pi 0. PMID- 9958482 TI - Statistical properties of cosmic-ray showers at ground level determined from photomultiplier-tube background registrations. PMID- 9958483 TI - Analytic forms for the e+e- annihilation cross section near the Z including initial-state radiation. PMID- 9958485 TI - K+-nucleon central interaction in a quark potential model. PMID- 9958484 TI - Heavy-Higgs-boson production and W-W+ scattering processes in e-e+ collisions at high energy. PMID- 9958486 TI - Multiplicity distributions from branching equations with constant vertex probabilities. PMID- 9958487 TI - Statistical and dynamical aspects of hadronic clusters in high-energy collisions: Statistical methods. PMID- 9958488 TI - Physics of heavy-quark production in quantum chromodynamics. PMID- 9958490 TI - Double scattering and infrared sensitivity for nuclear targets. PMID- 9958489 TI - On the production and decay of neutral technicolor pseudoscalars. PMID- 9958491 TI - Multiplicity distribution in ultrarelativistic nucleus-nucleus collisions. PMID- 9958492 TI - Energy spectra of neutrino-induced upward muons in underground experiments. PMID- 9958493 TI - Renormalized photon couplings of the Delta (1232). PMID- 9958495 TI - Effective chiral Lagrangian of pseudoscalar and vector mesons. PMID- 9958494 TI - eta - eta ' mixing angle. PMID- 9958496 TI - Restrictions on tau ---> eta pi - nu in two-Higgs-doublet models. PMID- 9958497 TI - Electromagnetic structure of the proton and baryon spectrum in the nonrelativistic quark model. PMID- 9958498 TI - Isospin violations in baryons and the Sigma c0- Sigma c++ mass difference. PMID- 9958499 TI - Calculation of diquark masses in QCD. PMID- 9958500 TI - Hadron spectrum on an 18(3) x 42 lattice. PMID- 9958501 TI - Measuring the hadronic spectrum of the quark plasma. PMID- 9958502 TI - Probabilistic derivation of parton splitting functions. PMID- 9958503 TI - The Bethe-Maximon result. PMID- 9958504 TI - Measurement of the D0 lifetime from the upgraded Mark II detector at the SLAC e+e storage ring PEP. PMID- 9958506 TI - Does quark-gluon-plasma formation suppress charmonium production? PMID- 9958505 TI - Polarized-proton-proton scattering at 90 degrees in the c.m. system. PMID- 9958507 TI - Oscillation searches via neutrino-electron scattering. PMID- 9958508 TI - Radiative weak hyperon decays and the s-->d gamma transition. PMID- 9958509 TI - Lepton masses and SU(3)family-symmetry breaking. PMID- 9958510 TI - Nonstandard interaction and the W-Z mass relation. PMID- 9958511 TI - Breaking of supersymmetry degeneracy and phenomenological conditions. PMID- 9958512 TI - Narrow e+e- peaks in heavy-ion collisions and a possible new phase of QED. PMID- 9958513 TI - Narrow e+e- peaks in heavy-ion collisions as possible evidence of a confining phase of QED. PMID- 9958514 TI - Baryon density in a chiral soliton model. PMID- 9958515 TI - Multihadronic events at Ec.m. PMID- 9958518 TI - Angular distribution of W-boson pairs at a heavy Z resonance. PMID- 9958517 TI - Measurement of the average lifetime of hadrons containing bottom quarks. PMID- 9958516 TI - Production of four-prong final states in photon-photon collisions. PMID- 9958519 TI - Radiative corrections to the Z0 resonance. PMID- 9958520 TI - Top-quark production at electron-positron colliders. PMID- 9958521 TI - Production of leptoquark bosons in ultrahigh-energy neutrino interactions. PMID- 9958522 TI - Photoproduction of delta and Roper resonances in the cloudy bag model. PMID- 9958523 TI - Testing couplings of three vector bosons through hadron collisions at Fermilab Tevatron energy. PMID- 9958524 TI - Development of cascade showers in dense media. PMID- 9958525 TI - Low-energy atmospheric neutrinos. PMID- 9958527 TI - Semileptonic decays of top mesons. PMID- 9958526 TI - Fourth-generation t'-quarkonium formation and decay signatures. PMID- 9958528 TI - Inclusive B-meson decay rates. PMID- 9958529 TI - CP violation in KL--> pi + pi - gamma. PMID- 9958530 TI - Chiral-symmetry-breaking corrections in two-photon decays of pseudoscalar mesons. PMID- 9958532 TI - Spectroscopy of atomlike mesons Qq-bar in a semirelativistic theory. PMID- 9958531 TI - Mass spectrum of the strange dibaryon. PMID- 9958533 TI - Gauge-boson mass shifts for extended Higgs sectors. PMID- 9958534 TI - Self-consistency equation for the order parameter and restoration of chiral symmetry. PMID- 9958535 TI - From QCD to the low-energy effective action through composite fields: Goldstone's theorem and f pi. PMID- 9958537 TI - Dynamical composite models of electroweak bosons. PMID- 9958536 TI - E8 family unification, mirror fermions, and new low-energy physics. PMID- 9958539 TI - Geometry of spin effects in proton-proton scattering. PMID- 9958540 TI - Relative rates of W and Z events at the p-barp collider and nonstandard physics. PMID- 9958538 TI - Search for fractionally charged particles in (anti)neutrino-deuterium interactions. PMID- 9958541 TI - Number of neutrinos from W,Z hadroproduction: Last count. PMID- 9958542 TI - Multigluon processes and the Slavnov-Taylor identity. PMID- 9958543 TI - Erratum: Search for right-handed currents in muon decay PMID- 9958544 TI - The decay B-bar0--> pi +l- nu to probe Vbu. PMID- 9958545 TI - Low-, medium-, and high-transverse-energy events in hadron-hadron collisions? PMID- 9958547 TI - Do flavor conservation and spontaneous CP nonconservation lead to a real Kobayashi-Maskawa matrix? PMID- 9958546 TI - Signals for hadronic modes in the quark plasma. PMID- 9958548 TI - Gravitational light deflection and the dragging of inertial frames. PMID- 9958549 TI - Effect of the Sun's gravity on the distribution and detection of dark matter near the Earth. PMID- 9958550 TI - Astrophysical constraints on axion and Majoron couplings. PMID- 9958551 TI - General-relativistic implicit hydrodynamics in polar-sliced space-time. PMID- 9958552 TI - Solution of the horizon and flatness problems by multiple inflations. PMID- 9958553 TI - Inflation-produced, large-scale magnetic fields. PMID- 9958555 TI - Membrane viewpoint on black holes: Gravitational perturbations of the horizon. PMID- 9958554 TI - Bulk-viscosity-driven asymmetric inflationary universe. PMID- 9958556 TI - New family of exact solutions for colliding plane gravitational waves. PMID- 9958557 TI - Colliding almost-plane gravitational waves: Colliding plane waves and general properties of almost-plane-wave spacetimes. PMID- 9958558 TI - Quantum kinematics of spacetime. I. Nonrelativistic theory. PMID- 9958559 TI - Gravitational theta states and the wave function of the universe. PMID- 9958561 TI - Aspects of QED and non-Abelian gauge theories in S1 PMID- 9958560 TI - Index theorems and superconducting cosmic strings. PMID- 9958562 TI - Massless scalar and antisymmetric tensor fields in de Sitter space. PMID- 9958564 TI - Quantum kinetic field theory in curved spacetime: Covariant Wigner function and Liouville-Vlasov equations. PMID- 9958563 TI - Nonequilibrium quantum fields: Closed-time-path effective action, Wigner function, and Boltzmann equation. PMID- 9958565 TI - Spontaneous compactification and coupling constants in R2 unified gauge theories. PMID- 9958566 TI - Conformal field theory and the geometry of second quantization. PMID- 9958567 TI - Global gauge anomalies for simple Lie algebras. PMID- 9958568 TI - Superrenormalizability in a model with supersymmetry breaking. PMID- 9958569 TI - Universal behavior of D-dimensional superstring models. PMID- 9958570 TI - Casimir force on a solid ball when epsilon ( omega ) micro( omega )=1. PMID- 9958571 TI - Feynman path integral for fermions. PMID- 9958572 TI - Chiral-symmetry breaking in QCD. III. Arbitrary covariant gauge. PMID- 9958573 TI - Exact ground-state properties of SU(3) Hamiltonian lattice gauge theory. PMID- 9958574 TI - Improved variational wave functions for SU(3) Hamiltonian lattice gauge theory. PMID- 9958576 TI - Regulating 1/(k+)n singularities in discrete light-cone quantization. PMID- 9958575 TI - Variational calculation of the spectrum of two-dimensional phi4 theory in light front field theory. PMID- 9958578 TI - Vacuum and excited states of Coulomb-gauge SU(n) Yang-Mills fields. PMID- 9958577 TI - N=(1/2 hidden symmetries. PMID- 9958579 TI - Transport theory of the quark-gluon plasma based on an operator-field Langevin equation. PMID- 9958580 TI - Vacuum contribution to the electric polarizability in 1+1 dimensions. PMID- 9958581 TI - On the magnitude of baryon-to-photon ratio inhomogeneities resulting from a first order quark-hadron transition. PMID- 9958582 TI - Domain walls with bound Bose condensates. PMID- 9958583 TI - Radiative corrections to the solar-neutrino counting rate in the gallium detector. PMID- 9958584 TI - Correction to "Acceleration radiation and the generalized second law of thermodynamics" PMID- 9958585 TI - Focusing process in the collision of gravitational plane waves. PMID- 9958586 TI - Limit properties of Feynman integrals in noncovariant algebraic gauges. PMID- 9958587 TI - Critical dimensions for chiral bosons. PMID- 9958588 TI - Hamiltonian formulation and BRS quantization of the fermionic string in the covariant gauge. PMID- 9958589 TI - Eigenmodes for fluctuations about the classical solutions in the generalized Liouville equation. PMID- 9958590 TI - Effective scalar field theory of p-adic string. PMID- 9958591 TI - Twisting, type-N vacuum gravitational fields with symmetries. PMID- 9958592 TI - Determination of alpha s from energy-energy correlations in e+e- annihilation at 29 GeV. PMID- 9958594 TI - Experimental limit for the charge of the free neutron. PMID- 9958593 TI - Search for new, long-lived, neutral particles. PMID- 9958595 TI - Global charge conservation and hadronic multiplicity distribution in a rapidity window for e+e- processes. PMID- 9958596 TI - Radiative capture of stopped kaons: K-p--> Lambda gamma and K-p--> Sigma 0 gamma. PMID- 9958597 TI - Rapidity scaling of multiplicity distributions in a quantum-statistical approach. PMID- 9958598 TI - Multiparticle correlations from transverse-energy distributions. PMID- 9958599 TI - Delta sigma L(pp) and jet physics. PMID- 9958600 TI - Top-quark signatures at the Fermilab Tevatron collider. PMID- 9958601 TI - Hadronic production of charged Higgs bosons. PMID- 9958602 TI - Scalar-leptoquark production at hadron colliders. PMID- 9958603 TI - Higgs-boson production via pseudoscalar toponium. PMID- 9958604 TI - Semileptonic decays of heavy top mesons. PMID- 9958605 TI - Asymmetry between inclusive charmed and anticharmed modes in B0, B-bar0 decay as a measure of CP violation. PMID- 9958606 TI - Higgs-boson decay to one real and one virtual W boson. PMID- 9958607 TI - Strong-interaction effects on the baryon semileptonic decay form factors. PMID- 9958609 TI - Quarkonium annihilation rates. PMID- 9958608 TI - Electrons and photons trapped in bags of abnormal QED vacuum. PMID- 9958610 TI - Tensor-meson dominance and glueball candidate theta (1720). PMID- 9958611 TI - Generation-changing processes in two-Higgs-doublet models. PMID- 9958612 TI - Constraints on the Majoron interactions from the supernova SN1987A. PMID- 9958613 TI - Shock phenomena in supercooled baryon-free strongly interacting matter. PMID- 9958614 TI - Bose-Einstein correlation of particles produced by expanding sources. PMID- 9958616 TI - Realistic pseudoscalar-vector chiral Lagrangian and its soliton excitations. PMID- 9958615 TI - Color correlations in QCD plasma. PMID- 9958617 TI - Hadrons in an SL PMID- 9958619 TI - Elastic scattering in thick targets and edge scattering. PMID- 9958618 TI - Yukawa couplings and phenomenology of a three-generation superstring model with a new complex structure. PMID- 9958620 TI - Quantum beamstrahlung from ribbon pulses. PMID- 9958621 TI - Single-top-quark production in e+e- collisions via superstring Yukawa interactions. PMID- 9958623 TI - Mid-rapidity transverse-energy distributions and multisource model for hadron nucleus and nucleus-nucleus collisions. PMID- 9958622 TI - Baryon-nucleon scattering at low energies. PMID- 9958624 TI - Two-photon decay of pseudoscalar mesons in hot hadronic matter. PMID- 9958626 TI - Hyperfine splitting of P states in heavy quarkonia. PMID- 9958625 TI - Analysis of the rho mass spectrum in tau decay. PMID- 9958627 TI - Charged scalars and B0B-bar 0 mixing. PMID- 9958628 TI - Explicit sigma meson, topology, and the large-N limit of the Skyrmion. PMID- 9958630 TI - Analysis of QCD corrections to the decay Z-->W + hadrons. PMID- 9958629 TI - Erratum: eta - eta ' mixing angle PMID- 9958632 TI - Matter oscillations: Neutrino transformation in the Sun and regeneration in the Earth. PMID- 9958633 TI - Black-hole normal modes: A WKB approach. III. The Reissner-Nordstrom black hole. PMID- 9958631 TI - Angular distribution of events from SN1987A. PMID- 9958635 TI - Cosmological consequences of a rolling homogeneous scalar field. PMID- 9958634 TI - Signal modulation in cold-dark-matter detection. PMID- 9958637 TI - Gravitational field of a global string. PMID- 9958636 TI - Gravitational production of scalar particles in inflationary-universe models. PMID- 9958638 TI - Primordial nucleosynthesis: The effects of injecting hadrons. PMID- 9958639 TI - Theories of gravitation in two dimensions. PMID- 9958640 TI - Power-law-lapse time gauges. PMID- 9958641 TI - Electromagnetic characteristics of the dynamics of a self-gravitating quasineutral plasma. PMID- 9958642 TI - Formal commutators of the gravitational constraints are not well defined: A translation of Ashtekar's ordering to the Schrodinger representation. PMID- 9958643 TI - Entropy generation, particle creation, and quantum field theory in a cosmological spacetime: When do number and entropy increase? PMID- 9958644 TI - Semiclassical physics and quantum fluctuations. PMID- 9958645 TI - Simple form for the Gaussian equations in curved space. PMID- 9958646 TI - Bubbles without cores. PMID- 9958647 TI - Hamiltonian formulation of a gauge-invariant massive spin-(3/2 theory. PMID- 9958648 TI - Regularization ambiguities of the nonlinear sigma model in 2 and 2+ epsilon dimensions. PMID- 9958649 TI - Quantum fields out of thermal equilibrium. PMID- 9958650 TI - BRST quantization of a local supersymmetric chiral boson-fermion system. PMID- 9958652 TI - Schwinger terms of the super-Virasoro algebra in (1,0) superspace. PMID- 9958651 TI - Supersymmetric regularized path-integral measure in x space. PMID- 9958654 TI - Excited-state vertices for type-I superstrings. PMID- 9958653 TI - OSp(2,2||4) for open-string fields. PMID- 9958656 TI - Quantization of a constituent-string model in four dimensions. PMID- 9958655 TI - General coupling of strings to the low-energy effective theory. PMID- 9958657 TI - Scattering and decay theory for quaternionic quantum mechanics, and the structure of induced T nonconservation. PMID- 9958658 TI - Quantum-mechanical aspects of SU(3) Skyrme model in collective-coordinate quantization. PMID- 9958659 TI - Four-quark interactions in finite-temperature, SU(2), lattice gauge theory. PMID- 9958661 TI - Hamiltonian lattice QCD at finite temperature and chemical potential. I. Minimum principle and Bogoliubov approximation. PMID- 9958660 TI - Complex Langevin solution to an effective theory of lattice QCD. PMID- 9958662 TI - Hamiltonian lattice QCD at finite temperature and chemical potential. II. Gauss law constraint on the thermal excitations. PMID- 9958663 TI - Thermodynamical properties of a class of models with non-Abelian internal symmetries at finite temperature and baryon number. PMID- 9958664 TI - Friedel oscillations in relativistic QED and QCD. PMID- 9958665 TI - Observable monochromatic photons from cosmic photino annihilation. PMID- 9958666 TI - Wick-Cutkosky model in the large-temperature limit. PMID- 9958668 TI - World surfaces of the conformal anomaly of the dual string. PMID- 9958667 TI - Calculating the two-loop effective potential of the Weinberg-Salam model. PMID- 9958669 TI - Bosonization of the ghost fields and one-loop partition function. PMID- 9958670 TI - Cosmological constant and the strong CP problem. PMID- 9958671 TI - Perfect-fluid cosmologies with extra dimensions. PMID- 9958673 TI - Partition-function approach to the Gaussian effective potential. PMID- 9958672 TI - Propagator in the fully fixed temporal gauge. PMID- 9958674 TI - Autonomous lambda phi4 theory in a time-dependent space-time. PMID- 9958675 TI - Finite-size effects and phase transitions. PMID- 9958676 TI - Comment on "Equivalence between the Thirring model and a derivative-coupling model" PMID- 9958677 TI - Comment on "Equivalence between the Thirring model and a derivative-coupling model" PMID- 9958678 TI - Erratum: Dual long-distance QCD PMID- 9958680 TI - Bosonic superconducting cosmic strings. PMID- 9958679 TI - Fields due to kinky, cuspless, cosmic loops. PMID- 9958681 TI - Dynamics of cosmic string. PMID- 9958682 TI - Supernova neutrinos and their oscillations. PMID- 9958683 TI - Hypercylindrical black holes. PMID- 9958684 TI - Weyl curvature tensor in static spherical sources. PMID- 9958686 TI - Dilatons, flatness, and the cosmological constant. PMID- 9958685 TI - Reading off gravitational radiation waveforms in numerical relativity calculations: Matching to linearized gravity. PMID- 9958687 TI - Supergravity solitons. I. General framework. PMID- 9958688 TI - Notes on the Hawking effect in de Sitter space. I. PMID- 9958689 TI - Notes on the Hawking effect in de Sitter space. II. PMID- 9958690 TI - High-energy unitarity of gravitation and strings. PMID- 9958691 TI - Strings on an orbifold with background gauge fields. PMID- 9958692 TI - Heterotic string on the simplest Calabi-Yau manifold and its orbifold limits. PMID- 9958693 TI - Regularized BRST-coordinate-invariant measure. PMID- 9958694 TI - Becchi-Rouet-Stora-Tyutin Hamiltonian method and the membrane model. PMID- 9958695 TI - Finite-temperature effects on the Gaussian effective potential. PMID- 9958696 TI - Solvable light-front model of a relativistic bound state in 1+1 dimensions. PMID- 9958698 TI - Hamiltonian analysis of topologically massive Yang-Mills theory. PMID- 9958697 TI - On the existence of the chiral Schwinger model. PMID- 9958699 TI - Deformation of symplectic structure and anomalous commutators in field theories. PMID- 9958700 TI - Poincare invariance of anomalous gauge theories. PMID- 9958701 TI - Are ghosts necessary in planar gauges? PMID- 9958702 TI - Overrelaxation algorithms for lattice field theories. PMID- 9958703 TI - Lanczos calculation of the spectrum of Hamiltonian lattice gauge theory. PMID- 9958704 TI - Hamiltonian strong-coupling expansions for (2+1)-dimensional quantum electrodynamics. PMID- 9958705 TI - String tension from the Schwinger-Dyson equation for a Wilson loop. PMID- 9958707 TI - Superconductivity: A testing ground for models of confinement. PMID- 9958706 TI - Some recoil corrections to the hydrogen hyperfine splitting. PMID- 9958708 TI - Operator method for finding new propagators from old. PMID- 9958709 TI - Bounds on the energy of the N-body problem with linear combinations of power-law potentials and the logarithmic potential. PMID- 9958710 TI - On the "averaged weak energy condition" and Penrose's singularity theorem. PMID- 9958711 TI - Bounds on light, weakly interacting particles from observational lifetimes of helium-burning stars. PMID- 9958712 TI - Neutrino vacuum oscillation and neutrino burst from SN1987A. PMID- 9958713 TI - BRST Hamiltonian quantization of a spinless particle in a curved background. PMID- 9958714 TI - Effect of zero modes in statistical mechanics. PMID- 9958716 TI - Lattice Hamiltonian in physical gauges. PMID- 9958715 TI - Non-Abelian theory for massive vector bosons and canonical quantization. PMID- 9958718 TI - Chiral anomaly for parafermions from stochastic quantization. PMID- 9958717 TI - Parity-violating anomalies and the stationarity of stochastic averages. PMID- 9958719 TI - Experimental limits on massive neutrinos from e+e- annihilations at 29 GeV. PMID- 9958720 TI - Search for structures in the p-barp--> pi + pi - and p-barp-->K+K- cross sections between 360 and 760 MeV/c. PMID- 9958721 TI - Precise measurement of the asymmetry parameter delta in muon decay. PMID- 9958722 TI - Search for axions from the 1115-keV transition of 65Cu. PMID- 9958723 TI - Skyrmions and meson-baryon reactions. PMID- 9958724 TI - Asymmetries of heavy leptons in E6 theories at hadron colliders. PMID- 9958726 TI - On the detection of ultrahigh-energy neutrinos. PMID- 9958725 TI - Electromagnetic component of 1014-10(16)-eV air showers. PMID- 9958727 TI - Resonant oscillations of atmospheric neutrinos with an underground muon detector. PMID- 9958728 TI - Exclusive decays B-->K(i) gamma resulting from b-->s gamma. PMID- 9958729 TI - Constraints on semileptonic B decays from the measurement of the D polarization in B-->De nu -bar. PMID- 9958730 TI - Charmless B decays involving baryons. PMID- 9958731 TI - Omega ---> Xi - gamma and Omega ---> Xi -l+l- decays and the single-quark transition model. PMID- 9958733 TI - Invisible decays of Higgs bosons in supersymmetric models. PMID- 9958732 TI - Kinematical aspects of nonleptonic multiparticle decays of heavy baryons. PMID- 9958734 TI - Decay constants, mass formulas, and mixings with radially excited states of the light and heavy ground-state pseudoscalar mesons. PMID- 9958735 TI - Splitting of the P states in heavy quarkonium systems and the nature of the spin dependent potential. PMID- 9958736 TI - 1P1 data and the hyperfine interaction in quarkonia. PMID- 9958738 TI - Chiral model of the nucleon and Delta isobar: The coherent-pair approximation. PMID- 9958737 TI - Stability of dimesons. PMID- 9958739 TI - Uniqueness of the relativistic nucleon state. PMID- 9958740 TI - Relativistic model of nucleon and pion structure: Static properties and electromagnetic soft form factors. PMID- 9958741 TI - Supersymmetry phenomenology and the nature of the lightest supersymmetric particle. PMID- 9958743 TI - Exotic quarks in superstring models: Implications on CP violation and heavy-meson mixing. PMID- 9958742 TI - Lepton-vector-lepton mixings and unitarity bounds. PMID- 9958745 TI - Cross sections for single-tagged two-photon production of resonances. PMID- 9958744 TI - Gauge-invariant sets of diagrams for P0-P-bar 0 mixing. PMID- 9958746 TI - Supersymmetric-charged-Higgs-boson production at the Superconducting Super Collider. PMID- 9958747 TI - Mirror families and radiative SU2 x U1 breaking. PMID- 9958748 TI - Erratum: Strangeness production in ultrarelativistic heavy-ion collisions. I. Chemical kinetics in the quark-gluon plasma PMID- 9958750 TI - Inflation as a transient attractor in R2 cosmology. PMID- 9958749 TI - Probing the nature of the neutrino: The boron solar-neutrino experiment. PMID- 9958752 TI - Relativistic fluid flows around cosmic strings. PMID- 9958753 TI - Internal structure and the spacetime of superconducting bosonic strings. PMID- 9958751 TI - Self-intersections in a three-parameter space of cosmic strings. PMID- 9958755 TI - Quantum cosmology and the initial state of the Universe. PMID- 9958754 TI - Numerical experiments with cosmic strings in flat spacetime. PMID- 9958757 TI - Wormholes in spacetime. PMID- 9958756 TI - Uniqueness of the tunneling wave function of the Universe. PMID- 9958758 TI - Supergravity solitons. II. The free case. PMID- 9958759 TI - Motion of massive bodies: Testing the nonsymmetric gravitation theory. PMID- 9958760 TI - Oklo phenomenon and the principle of equivalence. PMID- 9958761 TI - Berry's phase, locally inertial frames, and classical analogues. PMID- 9958762 TI - Majorana Feynman rules. PMID- 9958763 TI - Chiral-symmetry breaking in continuum two-dimensional QCD by an infrared method. PMID- 9958764 TI - Non-Abelian gauge invariance and the infrared approximation. PMID- 9958766 TI - Closed smooth strings on a torus. PMID- 9958765 TI - Complex Langevin simulations of non-Abelian integrals. PMID- 9958768 TI - String vertex on the Grassmann manifold. PMID- 9958767 TI - Off-shell amplitudes for open bosonic strings. PMID- 9958769 TI - Anomaly-free theories in D=4k dimensions. PMID- 9958770 TI - Debye potentials for monopoles in U(1) and SU(2): Identification of Higgs remnant in electrodynamics. PMID- 9958771 TI - Perturbative tests of a lattice fermion proposal of Quinn and Weinstein. PMID- 9958773 TI - The sphaleron strikes back: A response to objections to the sphaleron approximation. PMID- 9958772 TI - Lattice QCD at finite density. PMID- 9958774 TI - Nontrivial homotopy and tunneling by topological instantons. PMID- 9958775 TI - Dual long-distance QCD. PMID- 9958777 TI - Lunar laser ranging and laboratory Eotvos-type experiments. PMID- 9958776 TI - Light-front Hamiltonian approach to relativistic two- and three-body bound-state problems in 1+1 dimensions. PMID- 9958778 TI - Geometrical representation of neutrino oscillations in vacuum and matter. PMID- 9958779 TI - Stability of the vacuum in scalar field models in 1+1 dimensions. PMID- 9958780 TI - Becchi-Rouet-Stora structure and gauge-invariant actions for higher-spin fields. PMID- 9958781 TI - Critical dimension of strings with an extrinsic curvature. PMID- 9958782 TI - Variational analysis of the Gross-Neveu model in an S1 space. PMID- 9958783 TI - Four-dimensional SU(2) Yang-Mills theory on a pseudorandom lattice. PMID- 9958785 TI - Variation of the Fermi constant and primordial nucleosynthesis. PMID- 9958784 TI - N=2 case of non-Abelian bosonization. PMID- 9958786 TI - Comment on "A reduction of order two for infinite-order Lagrangians" PMID- 9958787 TI - Nonsinglet valence-quark distribution from neutrino-deuterium deep-inelastic scattering. PMID- 9958788 TI - Correlations among particles produced in proton interactions with emulsion nuclei at 800 GeV. PMID- 9958789 TI - Search for strange baryonium states in p-bard interactions at 8.9 GeV/c. PMID- 9958790 TI - Searches for Majoron production and other processes associated with pi -->e nu decay. PMID- 9958791 TI - New limits on light scalar and pseudoscalar particles produced in nuclear decay. PMID- 9958792 TI - Exotic-atom measurement of the magnetic dipole moment of the Sigma - hyperon. PMID- 9958794 TI - Structure-function analysis and psi, jet, W, and Z production: Determining the gluon distribution. PMID- 9958793 TI - Small-signal analysis in high-energy physics: A Bayesian approach. PMID- 9958795 TI - Heavy leptons at hadron supercolliders. PMID- 9958797 TI - Pair production in transport equations. PMID- 9958796 TI - Axigluon production in hadronic collisions. PMID- 9958799 TI - Hadronic transitions and 1P1 states of heavy quarkonia. PMID- 9958798 TI - Cascade simulation of ultrarelativistic collisions. PMID- 9958801 TI - Electromagnetic transition properties of Delta to proton. PMID- 9958800 TI - Correlation between decay planes in Higgs-boson decays into a W pair (into a Z pair). PMID- 9958802 TI - Mixing effects on Z-boson properties in E6 theories. PMID- 9958804 TI - Glueball candidate iota (1460) and quarkonium-gluonium mixing. PMID- 9958803 TI - Mixing of the photon with low-mass particles. PMID- 9958806 TI - Null-plane formulation of Bethe-Salpeter qqq dynamics: Baryon mass spectra. PMID- 9958805 TI - Gupta-Radford-Repko potential and the properties of the Upsilon system. PMID- 9958807 TI - On the stability of the Skyrme-model soliton with unit Hopf charge. PMID- 9958808 TI - Bag formation in the presence of vector mesons. II. Inclusion of scalars. PMID- 9958809 TI - Model for light-cone quark confinement dynamics. PMID- 9958811 TI - Low-energy electroweak model from E6 x E'6 preons. PMID- 9958810 TI - Phenomenological constraints on grand unification in superstring-inspired models. PMID- 9958813 TI - Solvable model of beam-beam effects in e+e- colliding storage rings. PMID- 9958812 TI - Coupled-bunch instability in a circular accelerator and possible cures: Longitudinal-phase-space simulation. PMID- 9958815 TI - Nonperturbative QCD order parameters from e+e- data by analytic continuation. PMID- 9958814 TI - New production mechanisms for exotic quarks of superstring-inspired E PMID- 9958816 TI - Diffractive and nondiffractive gamma gamma processes. PMID- 9958818 TI - Can CP nonconservation in the quark mixing matrix start at order G3? PMID- 9958817 TI - Electromagnetic width of the sigma meson from the sigma model. PMID- 9958819 TI - Erratum: Comments on the relation between the mass of R Upsilon (1(1)P1) and the QCD scale parameter Lambda M-barS-bar PMID- 9958821 TI - First-order chiral phase transition with a realistic current-quark spectrum. PMID- 9958820 TI - Search for sequential heavy leptons in e+e- collisions at sqrt s-bar=52 GeV. PMID- 9958822 TI - Motion of the Earth and the detection of weakly interacting massive particles. PMID- 9958823 TI - Plasmon decay into low-mass bosons in stars. PMID- 9958824 TI - Implications of the triplet-Majoron model for the supernova SN1987A. PMID- 9958826 TI - Analytic conditions for three-neutrino resonant oscillations in matter. PMID- 9958825 TI - Resonant spin-flavor precession of solar and supernova neutrinos. PMID- 9958828 TI - Cosmic strings in an expanding spacetime. PMID- 9958827 TI - Quark-hadron phase transition in the early Universe: Isothermal baryon-number fluctuations and primordial nucleosynthesis. PMID- 9958830 TI - Tail-transported temporal correlations in the dynamics of a gravitating system. PMID- 9958829 TI - On theories of gravitation with nonlinear Lagrangians. PMID- 9958831 TI - Supergravity solitons. III. The background problem. PMID- 9958832 TI - Hyperspherical Rindler space, dimensional reduction, and de Sitter-space scalar field theory. PMID- 9958833 TI - Chiral anomaly of antisymmetric tensor fields. PMID- 9958834 TI - Variational calculations and renormalization. PMID- 9958835 TI - Novel perturbative scheme in quantum field theory. PMID- 9958837 TI - Line functional theory for strings. I. PMID- 9958836 TI - S-matrix generating functional and effective action. PMID- 9958838 TI - Line functional theory for strings. II. Spins and symmetries. PMID- 9958840 TI - String unification and threshold effects. PMID- 9958839 TI - Finite-temperature amplitudes in open-string systems. PMID- 9958842 TI - Fourier acceleration in lattice gauge theories. I. Landau gauge fixing. PMID- 9958841 TI - Perturbative analysis of the Gauss-law anomaly in chiral gauge theories. PMID- 9958843 TI - Fourier acceleration in lattice gauge theories. II. Matrix inversion and the quark propagator. PMID- 9958845 TI - Schwinger model on a finite-element lattice. PMID- 9958844 TI - Short-range interactions in the effective theory for Wilson lines. PMID- 9958847 TI - Analytic approach to weak-coupling SU(2) Hamiltonian lattice gauge theory. PMID- 9958846 TI - Nonequivalent stochastic models in lattice gauge theory. PMID- 9958848 TI - SU(2) gauge theory in a constant chromomagnetic background field. PMID- 9958850 TI - Supersymmetry in a two-dimensional interacting fermionic model. PMID- 9958849 TI - SU(N) global gauge anomalies in even dimensions. PMID- 9958851 TI - Calculating boson and fermion loops in 3+1 dimensions and the derivative expansion. PMID- 9958852 TI - Non-Abelian chiral bag model and its dependence on the boundary. PMID- 9958853 TI - Remarks on the first two events in the supernova burst observed by Kamiokande II. PMID- 9958854 TI - Neutrino masses and flavors emitted in the supernova SN1987A. PMID- 9958855 TI - Positivity of Bondi mass for R+R2 gravity. PMID- 9958856 TI - Consistent spin-one theories by Kaluza-Klein dimensional reduction. PMID- 9958857 TI - Stress tensors from effective potentials. PMID- 9958859 TI - Glueballs from spontaneous strings. PMID- 9958858 TI - Conformal counterterms and boundary conditions for open strings. PMID- 9958860 TI - Path-integral derivation of the Chern-Simons terms in heterotic string theories. PMID- 9958861 TI - Induced fermionic charge in background gauge theories in odd space-time dimensions. PMID- 9958863 TI - Erratum: Systematic search for anomaly-free theories PMID- 9958862 TI - The Berry phase and the Hannay angle. PMID- 9958865 TI - Coherent rho + production in neutrino-neon interactions. PMID- 9958864 TI - Charm production in nonresonant e+e- annihilations at sqrt s =10.55 GeV. PMID- 9958868 TI - Are the e+e- and lp multiplicity distributions Poissonian? PMID- 9958867 TI - Photino flux limits from the Harvard-Purdue-Wisconsin underground detector. PMID- 9958866 TI - Measurement of the tau lifetime. PMID- 9958869 TI - Strong-interaction effects in parity violation in pp scattering. PMID- 9958870 TI - Probing the three-vector-boson vertex at hadron colliders. PMID- 9958871 TI - Possible method for finding a heavy Higgs boson. PMID- 9958873 TI - Momentum correlations in heavy-quark hadroproduction. PMID- 9958872 TI - Photon pair production and the intermediate-mass Higgs boson. PMID- 9958875 TI - Analyses of moments in pseudorapidity intervals at sqrt s =546 GeV by means of two probability distributions in pure-birth process. PMID- 9958876 TI - Geometrical branching model: Correlations and jets. PMID- 9958874 TI - Charm and the rise of the pp-bar total cross section. PMID- 9958877 TI - Hadron production in hadron-nucleus and nucleus-nucleus collisions in the dual Monte Carlo multichain fragmentation model. PMID- 9958878 TI - Pattern of J/ psi suppression in ultrarelativistic heavy-ion collisions. PMID- 9958879 TI - Transformation of neutron polarization in polarized media and tests of T invariance. PMID- 9958880 TI - CP-violating lepton asymmetry due to B-B-bar mixing. PMID- 9958881 TI - Top-quark issues at high-energy e+e- colliders. PMID- 9958882 TI - Do data on W and Z decays already constrain nonstandard physics? PMID- 9958883 TI - Gluino decay patterns and signatures. PMID- 9958884 TI - On the Wilson coefficient of the penguin operator. PMID- 9958885 TI - Weak radiative baryon decays in the Skyrme model. PMID- 9958886 TI - Neutrino masses in superstring-inspired models. PMID- 9958887 TI - Derivation of the formalism for neutrino matter oscillations from the neutrino relativistic field equations. PMID- 9958888 TI - Heavy leptons and the electric dipole moment of the electron. PMID- 9958889 TI - SU(6) violations due to one-gluon exchange. PMID- 9958890 TI - Isoscalar-meson mass shift due to the two-gluon intermediate state. PMID- 9958891 TI - Dirac quantization of pi rho omega solitons. PMID- 9958892 TI - Chiral nontopological solitons with perturbative quantum pions. PMID- 9958893 TI - Two-body Dirac equations for meson spectroscopy. PMID- 9958894 TI - Experimental test for arion photon oscillations in a homogeneous constant magnetic field. PMID- 9958896 TI - Implications of the decay Ds--> pi + pi - pi + PMID- 9958895 TI - Improving the heavy-Higgs-boson two-charged-lepton-two-neutrino signal. PMID- 9958897 TI - Potentially large contributions to the muon anomalous magnetic moment from weak isosinglet squarks in E6 superstring models. PMID- 9958898 TI - Constraints from the Drell-Hearn-Gerasimov sum rule in chiral models of composite fermions. PMID- 9958899 TI - Nonperturbative treatment of the gluonic ground state of QCD. PMID- 9958901 TI - Nucleon-nucleon scattering amplitudes and the classical scattering of Skyrmions. PMID- 9958900 TI - Search for the decay D0-->e+e- PMID- 9958902 TI - Nucleon distribution amplitudes from a relativistic quark model. PMID- 9958903 TI - Resonant axion-photon conversion in magnetized plasma. PMID- 9958904 TI - Strangeness condensation and cooling of neutron stars. PMID- 9958905 TI - Limits on mass of the neutrino. PMID- 9958906 TI - Nonequilibrium thermodynamic fluctuations of black holes. PMID- 9958907 TI - Post-inflationary era and baryogenesis. PMID- 9958908 TI - Thermal fluctuations in new inflation. PMID- 9958909 TI - Stochastic gravity-wave background in inflationary-universe models. PMID- 9958910 TI - What is the relation between Delta phi and micro for a cosmic string? PMID- 9958911 TI - Back-reaction of a scalar quantum field on curved space: An exact solution of the semiclassical equations. PMID- 9958913 TI - Baryon-number inhomogeneity generation in the cosmic quark-hadron phase transition. PMID- 9958912 TI - Growth of scalar-field quantum fluctuations in Robertson-Walker universes. PMID- 9958915 TI - Triad approach to the Hamiltonian of general relativity. PMID- 9958914 TI - Scalar-field fluctuations and the baryon asymmetry of the Universe. PMID- 9958916 TI - Colliding electromagnetic shock waves in general relativity. PMID- 9958917 TI - Exact solutions of the massive Klein-Gordon-Schwarzschild equation. PMID- 9958918 TI - Supergravity solitons. IV. Effective soliton interaction. PMID- 9958919 TI - Gravitational vacuum polarization around static spherical stars. PMID- 9958920 TI - Quantum effects of interacting fields in the early Universe. PMID- 9958921 TI - Generalized Wigner functions in curved spaces: A new approach. PMID- 9958922 TI - Renormalized evolution equations for the back-reaction problem with a self interacting scalar field. PMID- 9958923 TI - Calculating the effective action for a self-interacting scalar quantum field theory in a curved background spacetime. PMID- 9958924 TI - Quasi-invariance and central extensions. PMID- 9958925 TI - Functional representation for fermionic quantum fields. PMID- 9958926 TI - Stable field configurations in the large-N limit: Stochastic approach. PMID- 9958927 TI - Decompositions of representations of exceptional affine algebras with respect to conformal subalgebras. PMID- 9958929 TI - Space-time fermions and superghosts from the bosonic string: Generation of OSp(9,1||2) x OSp(3,3||6) affine superalgebra. PMID- 9958928 TI - Evaluation of the conformal anomaly of Polyakov's string theory by the stochastic quantization method. PMID- 9958930 TI - Beta-function computation without the use of normal coordinates. PMID- 9958932 TI - D-dimensional instantons in D+1 dimensions: A physical model for interactions. PMID- 9958931 TI - Soliton-antisoliton annihilation in 1+1 dimensions: Time-dependent Hartree approach. PMID- 9958934 TI - Chiral-symmetry breaking in QCD. I. The infrared domain. PMID- 9958933 TI - Confinement and a dual structure in the generalized chiral Schwinger model. PMID- 9958935 TI - Chiral-symmetry breaking in QCD. II. Running coupling constant. PMID- 9958936 TI - Phase structure of lattice SU(2) QCD with finite chemical potential. PMID- 9958937 TI - Semiclassical analysis of the weak-coupling limit of SU(2) lattice gauge theory: The subspace of constant fields. PMID- 9958938 TI - Linear lattice gauge theory with Nicolai mapping. PMID- 9958939 TI - Dual potentials in non-Abelian gauge theories. PMID- 9958940 TI - Pseudodeconfinement and dynamical confinement in the quark plasma. PMID- 9958941 TI - Cosmic strings in extra dimensions. PMID- 9958942 TI - Effective string tension in the finite-temperature smooth-string model. PMID- 9958943 TI - Flow-gauge Slavnov-Taylor identities for Zwanziger's gauge fixing. PMID- 9958945 TI - Comparison of quantization methods for anomalous chiral models. PMID- 9958944 TI - Charge screening in classical scalar electrodynamics. PMID- 9958947 TI - Superconducting Thirring model. PMID- 9958946 TI - Comments on dynamical mass versus superconducting gap generation. PMID- 9958948 TI - Boundary conditions and renormalization in anti-de Sitter supersymmetry. PMID- 9958950 TI - Comment on a paper by Pauli and Brodsky. PMID- 9958949 TI - Response to "Boundary conditions and renormalization in anti-de Sitter supersymmetry" PMID- 9958951 TI - Quantization on the light cone: Response to a Comment by Hagen. PMID- 9958952 TI - Absence of the nonrenormalizable superpotential in the sigma -model perturbation for smooth (0,2) compactifications. PMID- 9958953 TI - Invariant Berry connections. PMID- 9958954 TI - Production and decay properties of the omega pi 0 state at 1250 MeV/c2 produced by 20-GeV polarized photons on hydrogen. PMID- 9958956 TI - Transient-response induction detectors for magnetic monopoles: First operation at 78 K. PMID- 9958957 TI - W-Z interference in nu -nucleus scattering. PMID- 9958958 TI - The reaction gamma gamma --> pi 0 pi 0 and chiral loops. PMID- 9958955 TI - Measurement of the D0, D+, and Ds+ lifetimes. PMID- 9958959 TI - Flux-tube rearrangement and meson-meson scattering. PMID- 9958960 TI - Multijet cross sections in hadronic collisions. PMID- 9958961 TI - Poisson-distributed cluster models for multiparticle production. PMID- 9958962 TI - Rapidity-interval dependence of multiplicity fluctuation. PMID- 9958963 TI - Approximate higher-order corrections and changes of scales in large-pT physics. PMID- 9958965 TI - WW production at supercollider energies. PMID- 9958964 TI - Comparison of discovery limits for E6 neutral gauge bosons at future colliders. PMID- 9958967 TI - New phase of QED? PMID- 9958966 TI - Diffusion of charmed quarks in the quark-gluon plasma. PMID- 9958968 TI - Excited weak gauge bosons at colliders. PMID- 9958970 TI - Two-body decays of neutralinos and charginos. PMID- 9958969 TI - Radiative corrections to heavy-Higgs-scalar production and decay. PMID- 9958972 TI - Analytic expression for baryon semileptonic decay rate. PMID- 9958971 TI - Role of longitudinally polarized W 's in slepton production and decay. PMID- 9958974 TI - M1 transitions involving the D states of quarkonia. PMID- 9958973 TI - B-meson decays and the Weinberg Higgs-boson model of CP violation. PMID- 9958975 TI - Hadronic transitions of D-wave quarkonium. PMID- 9958976 TI - Radiative and pionic decays of the D mesons and the magnetic moment of the charmed quark. PMID- 9958977 TI - Effects of d-state quarks on the nucleon electric form factors. PMID- 9958978 TI - Neutrinoless double-beta decay with Majoron emission. PMID- 9958979 TI - Highly accurate solution of the neutron-antineutron-transition problem in an external oscillating magnetic field. PMID- 9958980 TI - Reexamining the Fritzsch-Stech SO(10) model of quarks and leptons. PMID- 9958982 TI - Sudakov suppression of color correlations in multiparton scattering. PMID- 9958981 TI - Particle-antiparticle and hybrid bound states involving exotic colored fermions. PMID- 9958983 TI - Zero-point energy in flux-tube confinement. PMID- 9958984 TI - Supersymmetry breaking in superstring-inspired models. PMID- 9958985 TI - Uncertainties in the np interaction at medium energies. PMID- 9958986 TI - Z0Z0 and W+W- pair production at supercollider energies. PMID- 9958987 TI - Charmonium states in the quark-gluon plasma. PMID- 9958988 TI - Top-quark decays when mt PMID- 9958989 TI - Long-distance-physics approach to the D pi and D* pi decays of B mesons. PMID- 9958990 TI - Comparison of the vector- and axial-vector-meson exchange contributions to the decay rate of the short-lived neutral kaon into two photons. PMID- 9958991 TI - Static electromagnetic properties of baryons in the chiral soliton model and in the naive quark model for three flavors and an arbitrary number of colors. PMID- 9958992 TI - Formation of spin-one mesons by photon-photon fusion. PMID- 9958994 TI - Apparent observation of abnormally large coherent scattering cross sections using keV and MeV range antineutrinos, and solar neutrinos. PMID- 9958993 TI - New measurements of properties of the Omega - hyperon. PMID- 9958996 TI - Deep-inelastic scattering in a modified bag model. PMID- 9958995 TI - Polarization effects in e+e--->Z0 gamma. PMID- 9958998 TI - Hadroproduction of W+/- pairs in an extended electroweak model. PMID- 9958997 TI - Stochastical dynamics and charge conservation in hadronization. PMID- 9958999 TI - Production of flavor-changing gauge bosons from E6 at e+e- and hadron colliders. PMID- 9959001 TI - Cosmic-ray neutrinos in the atmosphere. PMID- 9959000 TI - High-energy nucleon-nucleus scattering and cosmic-ray cross sections. PMID- 9959002 TI - Nonlinear effects in the flux-tube model for ultrarelativistic nucleus-nucleus collisions. PMID- 9959003 TI - Production and detection of the Higgs bosons of the simplest E6-based superstring inspired model. PMID- 9959004 TI - Solution to the puzzle of Gamma (D0-->K+K-)/ Gamma (D0--> pi + pi -) in a unified approach to D--> pi K-bar,KK-bar, and pi pi and K--> pi pi decays. PMID- 9959005 TI - Decay of mesons in flux-tube quark model. PMID- 9959006 TI - Relativistic analysis of neutron beta decay at finite density. PMID- 9959007 TI - Relativistic theory of the decay of upsilon into Higgs boson + photon. PMID- 9959008 TI - Relativistic treatment of light quarks in D and B mesons and W-exchange weak decays. PMID- 9959009 TI - Pion decay of baryons in a flux-tube quark model. PMID- 9959010 TI - Dynamical chiral-symmetry breaking and determination of the quark masses. PMID- 9959011 TI - D-wave quarkonium levels of the Upsilon family. PMID- 9959013 TI - Gauge and Higgs bosons in a model of generation nonuniversality. PMID- 9959012 TI - Flavor-octet dibaryons in the quark model. PMID- 9959014 TI - Flavor-changing effects via Higgs particles in E6 superstring-inspired models. PMID- 9959015 TI - Generalization of Sirlin's asymptotic theorem in a class of gauge theories based on SU(2) x U(1) x G. PMID- 9959016 TI - Radiative-induced fermion masses. PMID- 9959017 TI - Kobayashi-Maskawa matrix from the leading-order solution of the n-generation Fritzsch model. PMID- 9959018 TI - Skyrme model and strong-coupling model. PMID- 9959019 TI - Skyrme model including rho and A1 mesons. PMID- 9959020 TI - Finite-size effect in the Schwinger particle-production mechanism. PMID- 9959021 TI - Diquark clusters in the quark-gluon plasma. PMID- 9959022 TI - Spontaneous CP violation in theories with low-energy supersymmetry. PMID- 9959023 TI - Nonperturbative unification in the manner of Maiani, Parisi, and Petronzio at intermediate energies. PMID- 9959024 TI - Synchrotron radiation along the radial direction. PMID- 9959025 TI - W+W- pair production at resonances in the SU(2)L x SU(2)R x U(1) model. PMID- 9959026 TI - Interference effects and the longitudinal fraction in the process gg-->ZZ. PMID- 9959027 TI - Flavor-symmetry breaking and strong CP violation in the Skyrme model. PMID- 9959028 TI - Comment on the DeGrand-Miettinen model for the polarization of lambda in proton proton collisions. PMID- 9959029 TI - Modeling polarization asymmetry. PMID- 9959030 TI - A comment on Suzuki's model for composite vector mesons. PMID- 9959031 TI - Erratum: Yukawa couplings and phenomenology of a three-generation superstring model PMID- 9959033 TI - Z0-->ggg via AVV triangle diagram. PMID- 9959032 TI - Axigluons in the Upsilon system. PMID- 9959034 TI - Three-generation models with chiral-color interactions. PMID- 9959035 TI - Constraint on nonmetric theories of gravity from supernova 1987A. PMID- 9959036 TI - Mossbauer null red-shift experiment. PMID- 9959037 TI - Phenomenological aspects of new gravitational forces. IV. New terrestrial experiments. PMID- 9959038 TI - Astrophysical evidence for a weak new force? PMID- 9959039 TI - Initial conditions of a stringy universe. PMID- 9959040 TI - Topological picture of cosmic-string self-intersection. PMID- 9959041 TI - Rotating black hole in an external electromagnetic field. PMID- 9959042 TI - Naked singularities and the hoop conjecture: An analytic exploration. PMID- 9959043 TI - Distinct family of colliding gravitational waves in general relativity. PMID- 9959044 TI - Quantum kinematics of spacetime. II. A model quantum cosmology with real clocks. PMID- 9959045 TI - Spherically symmetric solutions of general second-order gravity. PMID- 9959047 TI - Changing coupling "constants" and violation of the equivalence principle. PMID- 9959046 TI - Magnetized Schwarzschild solution in five-dimensional gravity. PMID- 9959048 TI - Marginally trapped surfaces in a simplicial space. PMID- 9959049 TI - Existence and stability of nontopological strings. PMID- 9959051 TI - Geometric derivation of string field theory from first principles: Closed strings and modular invariance. PMID- 9959050 TI - Third quantization and the Wheeler-DeWitt equation. PMID- 9959052 TI - Modular-invariant closed-string field theory. PMID- 9959053 TI - Cosmological aspects of the heterotic string above the Hagedorn temperature. PMID- 9959054 TI - Topological approach to Weyl and super-Weyl anomalies in string theory. PMID- 9959056 TI - Light-cone gauge in Polyakov's theory. PMID- 9959055 TI - Renormalizing handles and holes in string theory. PMID- 9959057 TI - Soliton-particle scattering and Berry's phase. PMID- 9959058 TI - Generation structure and superpotential in string compactification on N=2 superconformal field theory. PMID- 9959059 TI - N=2 twisted supermodular transformation on a supertorus. PMID- 9959060 TI - Quantum evolution of an unstable field in a de Sitter-space thermal bath. PMID- 9959062 TI - Renormalization and conformal properties of sigma models on Riemannian space with torsion. PMID- 9959061 TI - On the hidden supersymmetry in stochastic quantization. PMID- 9959063 TI - Gauged BRS symmetry for the Weyl x Lorentz x diffeomorphism group. PMID- 9959065 TI - Gauge independence of the local trace anomaly of vectors and antisymmetric tensor fields. PMID- 9959064 TI - Non-Abelian gauge theories with Weyl fermions: The stochastic quantization approach. PMID- 9959066 TI - Quantum theory of nonlocal vortex fields. PMID- 9959067 TI - Canonical quantization of the interacting CP1 nonlinear sigma model with the Chern-Simons term. PMID- 9959068 TI - Multiloop integrals, counterterms, and renormalization of Yang-Mills theories in the light-cone gauge. PMID- 9959069 TI - Non-Abelian gauge couplings at finite temperature and density. PMID- 9959070 TI - Quasiperiodic instantons. PMID- 9959071 TI - Skyrme topological soliton coupled to gravity. PMID- 9959072 TI - Lattice lambda phi4 theory with Yukawa couplings to staggered fermions. PMID- 9959074 TI - Quenched monopoles in lattice gauge theory. PMID- 9959073 TI - Operator renormalization group. PMID- 9959075 TI - Hamiltonian lattice QCD at finite temperature and chemical potential. III. Critical curve of symmetry restoration for arbitrary number of colors and flavors. PMID- 9959076 TI - More on the QCD phase diagram at finite temperatures. PMID- 9959077 TI - Light-front QCD in the vacuum background. PMID- 9959079 TI - Reduction of the Breit Coulomb equation to an equivalent Schrodinger equation, and investigation of the behavior of the wave function near the origin. PMID- 9959078 TI - Dimensional reduction in finite-temperature quantum chromodynamics. II. PMID- 9959080 TI - Becchi-Rouet-Stora-Tyutin treatment of collective coordinates. PMID- 9959081 TI - Limits on CP invariance in general relativity. PMID- 9959082 TI - Weyl tensor and gravitational entropy. PMID- 9959084 TI - Gravitational time delay due to a spinning string. PMID- 9959083 TI - Spin-(3/2 massless field in a Kerr-Newman background metric. PMID- 9959085 TI - Static potential and the deconfinement temperature for Weyl-invariant rigid string. PMID- 9959086 TI - High-temperature expansion of the free energy of a massive scalar field in a curved space. PMID- 9959087 TI - Blow-up in nonlinear models of extended particles with confined constituents. PMID- 9959088 TI - Superconducting Schwinger model. PMID- 9959089 TI - Vacuum contribution to the electric polarizability in 1+1 dimensions-An addendum. PMID- 9959090 TI - Comment on "Bosonization in the chiral Schwinger model" PMID- 9959091 TI - Erratum: Minkowski Bessel modes PMID- 9959092 TI - Statistical study of tau-decay data. PMID- 9959093 TI - pi -p charge-exchange analyzing power from 547 to 687 MeV/c. PMID- 9959094 TI - Search for neutral metastable penetrating particles produced in the SLAC beam dump. PMID- 9959096 TI - Neutral current and the sum rules for spin-dependent electroproduction. PMID- 9959095 TI - Method of determining the gluon structure function from the cross section for the inelastic photoproduction of J/ psi. PMID- 9959097 TI - Particle productivity in pp and pA collisions. PMID- 9959099 TI - Multisource model and stochastic properties of multiparticle production in high energy nucleus-nucleus collisions. PMID- 9959098 TI - Charge conservation and representations of non-single-diffractive multiplicity distributions. PMID- 9959100 TI - Associated transverse energy in hadronic jet production. PMID- 9959101 TI - Nonstandard neutral weak boson and elastic electron-proton scattering. PMID- 9959102 TI - Production of the intermediate-mass Higgs boson in future electron-positron colliders. PMID- 9959103 TI - Production mechanisms for nonminimal Higgs bosons at an e+e- collider. PMID- 9959104 TI - Composite leptoquarks in hadronic colliders. PMID- 9959105 TI - Signatures for fourth-generation quarks and a heavy top quark at the Superconducting Super Collider. PMID- 9959106 TI - Transverse-momentum distribution of Higgs bosons at the Superconducting Super Collider. PMID- 9959107 TI - Can the Higgs bosons of the minimal supersymmetric model be detected at a hadron collider via two-photon decays? PMID- 9959108 TI - Branching ratio for a light Higgs boson to decay into micro+ micro- pairs. PMID- 9959109 TI - Searching for axicolor in toponium decays. PMID- 9959110 TI - Higgs-boson radiative corrections to the decay 3S1(QQ-bar)-->H gamma. PMID- 9959111 TI - The decay eta c-->pp-bar in a quark-diquark scheme. PMID- 9959112 TI - QCD short-distance enhancement in KL--> gamma gamma. PMID- 9959114 TI - Lattice calculation of weak amplitudes of D and B mesons. PMID- 9959113 TI - Deuteron as a toroidal Skyrmion. PMID- 9959115 TI - Radiatively induced seesaw mechanism for neutrino masses. PMID- 9959116 TI - Supergravity-induced E8 gauge hierarchies. PMID- 9959117 TI - Chiral-symmetry breaking at finite temperatures. PMID- 9959119 TI - Standard-model predictions for Bs0 weak decays. PMID- 9959118 TI - Chiral parameters in a Coulomb-gauge model of chiral-symmetry breaking. PMID- 9959120 TI - Effects of nonstandard gamma WW and ZWW vertices on spin asymmetries at supercollider energies. PMID- 9959121 TI - Nonperturbative quantum electrodynamics in a photon-condensate background field. PMID- 9959122 TI - Comment on "Small-signal analysis in high-energy physics: A Bayesian approach" PMID- 9959123 TI - Reply to "Comment on 'Small-signal analysis in high-energy physics: A Bayesian approach' " PMID- 9959125 TI - Dissociation kinetics and momentum-dependent J/ psi suppression in a quark-gluon plasma. PMID- 9959124 TI - chi 2(3555) hadroproduction and the polarized-gluon structure function. PMID- 9959126 TI - Finite-size effects in pair production by an external field. PMID- 9959127 TI - Neutrino flavor conversion in supernova 1987A. PMID- 9959128 TI - Clusters of galaxies from cosmic strings. PMID- 9959130 TI - Quantum effects in homogeneous multidimensional cosmologies. PMID- 9959129 TI - Axions and the anthropic principle. PMID- 9959132 TI - Adiabatic methods in the functional Schrodinger picture. PMID- 9959131 TI - Reducibility of parametrized systems. PMID- 9959133 TI - Graviton emission by a thermal bath of photons. PMID- 9959134 TI - Dynamics of charged bubbles in general relativity and models of particles. PMID- 9959135 TI - Relativistic charged-boson plasma in a magnetic field. II. PMID- 9959137 TI - Spin-(3/2 gravitational trace anomaly. PMID- 9959136 TI - Scalar field in a seven-dimensional manifold behaving as an SO(3)-covariant spinor field in space-time. PMID- 9959138 TI - Semitopological solitons. PMID- 9959139 TI - Exact classical solution for a Dirac field coupled to a pseudoscalar phi4 field theory. PMID- 9959140 TI - Twisted Thirring interaction and gauge-symmetry breaking in N=1 supersymmetric superstring models. PMID- 9959141 TI - Improvement of the derivative expansion. PMID- 9959142 TI - On-shell expansion of the effective action: S matrix and the ambiguity-free stability criterion. PMID- 9959143 TI - Wilson loops in the fermion-non-Abelian-vortex system. PMID- 9959144 TI - Two-photon-exchange force between charged systems: Spinless particles. PMID- 9959145 TI - Ultraviolet-improved gauge technique and the effective quark propagator in QCD. PMID- 9959146 TI - Horizontal branch stars and the neutrino signal from SN 1987A. PMID- 9959147 TI - Limits on contribution of cosmic nuclearites to galactic dark matter. PMID- 9959148 TI - Conserved energy for Robertson-Walker spacetimes with scalar fields. PMID- 9959150 TI - Dynamics of the lambda phi4 kink. PMID- 9959149 TI - Evaluation of the conformal anomaly of N=1 superstring theory by the stochastic quantization method. PMID- 9959151 TI - Dimensional reduction of higher-order topological invariants: The case CPn. PMID- 9959152 TI - Calculation of off-diagonal elements of the heat kernel. PMID- 9959153 TI - More on the two-dimensional O(4) sigma model. PMID- 9959155 TI - Chiral anomaly at finite temperature. PMID- 9959154 TI - Symmetries of the massless Dirac equation in Minkowski space. PMID- 9959157 TI - Comment on "Dynamics of false-vacuum bubbles" PMID- 9959156 TI - Comment on "Quantum gravity: Observational constraints on a pair of Yukawa terms" PMID- 9959158 TI - Infrared fixed points in asymptotically free field theories: What do they tell us? PMID- 9959159 TI - Noise behavior of the Garching 30-meter prototype gravitational-wave detector. PMID- 9959160 TI - Optimization of long-baseline optical interferometers for gravitational-wave detection. PMID- 9959162 TI - Numerical analysis of thermal fluctuations in new inflation. PMID- 9959161 TI - Observation in the Kamiokande-II detector of the neutrino burst from supernova SN1987A. PMID- 9959163 TI - Non-Gaussian perturbations from inflationary dynamics. PMID- 9959164 TI - Gravitational Faraday rotation induced by a Kerr black hole. PMID- 9959165 TI - Quantum cosmology with electromagnetism. PMID- 9959167 TI - Spin-two fields, general covariance, and conformal invariance. PMID- 9959166 TI - Fluid-flow description of density irregularities in the Universe. PMID- 9959168 TI - Rotating cosmic strings and gravitational soliton waves. PMID- 9959169 TI - Holonomy transformation and Aharonov-Bohm effect in an Einstein-Maxwell space time. PMID- 9959171 TI - Minkowski Bessel modes. PMID- 9959170 TI - Gupta-Bleuler quantization of massive superparticle models in 6, 8, and 10 dimensions. PMID- 9959172 TI - Dynamics and symmetries of a field partitioned by an accelerated frame. PMID- 9959173 TI - Spectrum of the Casimir effect. PMID- 9959174 TI - Dual operators and phase structure of the Z(4)-symmetric scalar field theory in 2+1 dimensions. PMID- 9959175 TI - Functional representation of the superconformal group in two dimensions. PMID- 9959176 TI - Generalized index theorem for string superconductivity in realistic models. PMID- 9959177 TI - Finite-temperature string theory and twisted tori. PMID- 9959178 TI - Involution-dependent constants and the cancellation of divergences in the one loop open-string amplitude. PMID- 9959179 TI - Smooth strings at large dimension. PMID- 9959180 TI - Axial anomaly and Schwinger terms in two-dimensional general quantum field theory. PMID- 9959181 TI - Charged-vortex solution to spontaneously broken gauge theories with Chern-Simons term. PMID- 9959182 TI - Perturbative quantization of the chiral Schwinger model. PMID- 9959183 TI - Correct Fujikawa regularization prescription in the chiral Schwinger model and the Wess-Zumino term. PMID- 9959185 TI - Quarks, noise, and the lattice. PMID- 9959184 TI - Chiral gauge theories on a lattice and application to the chiral Schwinger model. PMID- 9959186 TI - Axial anomaly and staggered fermions in the coordinate-space interpretation. PMID- 9959187 TI - Simulation of bosonized lattice fermion theories. PMID- 9959189 TI - Nonperturbative treatment of the functional Schrodinger equation in QCD. PMID- 9959188 TI - Linearizable quantum supersymmetric sigma models. PMID- 9959190 TI - Self-consistent model of confinement. PMID- 9959191 TI - Landau-Zener approximations for resonant neutrino oscillations. PMID- 9959192 TI - Neutrinos from SN1987A and the Cl experiment at the Homestake mine. PMID- 9959193 TI - Motion of test particles and light rays around massive conducting cosmic string. PMID- 9959194 TI - Gauge Higgs dynamics in the loop space. PMID- 9959195 TI - Remarks on noncompact sigma models. PMID- 9959196 TI - On the existence of localized solutions in self-consistent Yang-Mills-matter systems. PMID- 9959197 TI - Properties of a finite-temperature supersymmetric ensemble. PMID- 9959198 TI - Comment on "Calculating the weak scale in supergravity models" PMID- 9959199 TI - Reply to "Comment on 'Calculating the weak scale in supergravity models' " PMID- 9959200 TI - An improved presentation of a novel perturbative scheme in field theory. PMID- 9959201 TI - Erratum: Spectral decomposition of the perturbation response of the Schwarzschild geometry PMID- 9959202 TI - Spin-parameter measurements in Lambda and KS production. PMID- 9959203 TI - Measurement of the imaginary part of the I=1 N-barN S-wave scattering length. PMID- 9959204 TI - Measurement of pion-proton bremsstrahlung for pions at 299 MeV. PMID- 9959206 TI - Exclusive production of heavy mesons in e+e- annihilation. PMID- 9959205 TI - Contained neutrino interactions in an underground water detector. PMID- 9959207 TI - Vector- and tensor-meson production and the Pomeron-f identity hypothesis. PMID- 9959208 TI - A dependence in nuclear Drell-Yan processes including QCD corrections. PMID- 9959209 TI - Strange-baryon production via charge-changing weak currents in high-energy electron-capture reactions. PMID- 9959210 TI - CP violation in KL--> pi 0e+e-: Interference of one-photon and two-photon exchange. PMID- 9959211 TI - B-meson rare decays in two-Higgs-doublet models. PMID- 9959212 TI - b --> s gamma in the two-Higgs-doublet model. PMID- 9959213 TI - Doubly Okubo-Zweig-Iizuka-rule-violating effects in J/ psi decays. PMID- 9959215 TI - Tau missing-decay-mode problem and limits on a second tau neutrino. PMID- 9959214 TI - Radiative decays of the K-p atom. PMID- 9959216 TI - Anomaly-induced amplitudes of new gauge bosons. PMID- 9959217 TI - On estimating mean lifetimes in the presence of background. PMID- 9959218 TI - Anomalous moments of W bosons in broken-supersymmetric models. PMID- 9959220 TI - Three-family Fritzsch and Stech models with minimal and two-doublet Higgs structures. PMID- 9959219 TI - Analysis of the mixing matrix in a model with coincident quark electroweak and mass eigenstates. PMID- 9959221 TI - Mixing between ordinary and exotic fermions. PMID- 9959222 TI - Lepton-number violation and massless nonorthogonal neutrinos. PMID- 9959223 TI - Quark and lepton masses in superstring-type models with mirror families. PMID- 9959224 TI - Analytical and semiclassical aspects of matter-enhanced neutrino oscillations. PMID- 9959225 TI - Strange-quark content of the proton. PMID- 9959226 TI - Leptonic decay constant fB of the B(bd-bar) meson and the b-quark mass. PMID- 9959227 TI - Lattice pseudoscalar-meson wave-function properties. PMID- 9959228 TI - Simple supersymmetric strongly coupled preon model. PMID- 9959229 TI - Rosen-type derivation of the quark mixing matrix in three- and four-generation schemes. PMID- 9959230 TI - Cumulative beam break-up in a periodic linac. PMID- 9959231 TI - Disruption effects from the interaction of round e+e- beams. PMID- 9959234 TI - Higgs-boson-Z0 production from gluon fusion. PMID- 9959233 TI - Charged-particle multiplicity distribution and partition temperature. PMID- 9959232 TI - Observation of psi production in e+e- annihilation at 29 GeV. PMID- 9959235 TI - Nonperturbative unification of technicolor. PMID- 9959236 TI - High-transverse-momentum hadron-hadron correlations in sqrt s =38.8 GeV proton proton interactions. PMID- 9959237 TI - Determination of the gravitational constant at an effective mass separation of 22 m. PMID- 9959238 TI - Neutral-current reactions of solar and supernova neutrinos on deuterium. PMID- 9959239 TI - Excitation of quasinormal ringing of a Schwarzschild black hole. PMID- 9959241 TI - Hamiltonian lattice gravity. II. Discrete moving-frame formulation. PMID- 9959240 TI - Stability of a collapsed scalar field and cosmic censorship. PMID- 9959242 TI - Quantization of Robertson-Walker geometry coupled to a spin-(3/2 field. PMID- 9959243 TI - Renormalized graviton stress-energy tensor in curved vacuum space-times. PMID- 9959244 TI - Are there causal vacuum solutions with the symmetries of the Godel universe in higher-derivative gravity? PMID- 9959245 TI - Gauged Yang-Mills-Einstein supergravity with three-index field in seven dimensions. PMID- 9959246 TI - Inhomogeneous nucleosynthesis with neutron diffusion. PMID- 9959247 TI - Are cosmic strings frustrated? PMID- 9959248 TI - Anomalous particle creation, spectral asymmetry, and superconducting strings. PMID- 9959250 TI - Quantum probability distributions in the early Universe. I. Equilibrium properties of the Wigner equation. PMID- 9959249 TI - Inertial interpretation of the Unruh effect. PMID- 9959251 TI - Quantum probability distributions in the early Universe. II. The quantum Langevin equation. PMID- 9959252 TI - Cosmological domain-wall problem in the E8 x E8 superstring theory. PMID- 9959253 TI - One-loop corrections to the four-graviton interaction in type-II superstring theory and heterotic string theory. PMID- 9959254 TI - BRST-invariant tadpole calculation and diagrammatic formalism in the bosonic string. PMID- 9959255 TI - Diffeomorphism cohomology in quantum-field-theory models. PMID- 9959256 TI - Lagrangian and Hamiltonian BRST structures of the antisymmetric tensor gauge theory. PMID- 9959257 TI - Practical application of the unitary approximation to infrared singularities. PMID- 9959258 TI - Variational approach to lattice quantum mechanics. PMID- 9959260 TI - Studies of a model that interpolates between SU(2) and U(1) lattice gauge theories. PMID- 9959259 TI - Exact method for nonlinear fermions on finite lattice: Two dimensions. PMID- 9959261 TI - Equivalence of Dirac-Kahler and staggered lattice fermions in two dimensions. PMID- 9959262 TI - Tests of globally corrected hybrid updating. PMID- 9959263 TI - Global Monte Carlo algorithms for many-fermion systems. PMID- 9959265 TI - Light-cone quantization on the lattice. PMID- 9959264 TI - Renormalization of charge due to magnetic monopoles in the Villain form of U(1) lattice gauge theory. PMID- 9959267 TI - Finite-temperature transition for QCD with heavy quarks. PMID- 9959266 TI - Tuning the hybrid Monte Carlo algorithm. PMID- 9959269 TI - New perturbative calculation of the fermion-boson mass ratio in a supersymmetric quantum field theory. PMID- 9959268 TI - Derivation of chiral anomalies and commutator anomalies in a fixed-time regularization method. PMID- 9959270 TI - Strengths of shell-focusing singularities in marginally bound collapsing self similar Tolman spacetimes. PMID- 9959272 TI - Cosmological constraints on the radiative decay of heavy neutrinos in the fourth generation. PMID- 9959271 TI - Neutrino decay catalyzed by the Mikheyev-Smirnov-Wolfenstein effect. PMID- 9959273 TI - Neutrino electromagnetic spin-flip interactions in the Sun. PMID- 9959274 TI - New axionic instantons in quantum gravity. PMID- 9959275 TI - Energy-density spectrum of the vacuum around a cosmic string. PMID- 9959276 TI - Massive amplitudes of the open superstring. PMID- 9959277 TI - Ricci-flat and D=26 conditions from the string functional measures. PMID- 9959279 TI - Self-dual fields and the Thirring model. PMID- 9959278 TI - Four-dimensional parafermionic string. PMID- 9959280 TI - Stochastic derivation of conformal anomaly. PMID- 9959281 TI - Metropolis overrelaxation for lattice gauge theory for general relaxation parameter omega. PMID- 9959283 TI - "Gravitational" contributions to n-n-bar oscillations in vacuum. PMID- 9959282 TI - Onset of dynamical chaos in topologically massive gauge theories. PMID- 9959284 TI - Formation of the pseudoscalars pi 0, eta, and eta ' in the reaction gamma gamma - > gamma gamma. PMID- 9959285 TI - High-mass dimuon production in p-barN and pi -N interactions at 125 GeV/c. PMID- 9959286 TI - Hadronic interactions and primary-cosmic-ray composition at energies around 10(15)-10(16) eV derived from the analysis of high-energy gamma families. PMID- 9959287 TI - Properties of hadron families observed with thick-type emulsion chambers at Mts. Kanbala and Fuji and search for Centauro events. PMID- 9959288 TI - Primary-cosmic-ray protons above 1015 eV derived from the observation of superhigh-energy halo events. PMID- 9959289 TI - Heavy-Higgs-boson production and vector-boson scattering processes in e+e- collisions at high energy. PMID- 9959290 TI - Transverse-polarization effects at ep colliders. PMID- 9959291 TI - Reanalysis of weak radiative decays of hyperons. PMID- 9959292 TI - Final-state scattering in W+/- and Z0 decay. PMID- 9959293 TI - Hadronic transition amplitudes under null-plane Bethe-Salpeter dynamics. PMID- 9959294 TI - Anomalous magnetic moment of the muon and neutral-current constraints in a supersymmetric SU(2)L x U(1)I3R x U(1)B-L model inspired by superstring theories. PMID- 9959295 TI - Limits on photino and squark masses from proton lifetime in supergravity models. PMID- 9959297 TI - Effective Lagrangian for low-energy hadron physics with anomalies. PMID- 9959296 TI - Model dependence of the chargino mass bound from the CERN collider data. PMID- 9959298 TI - Generalization of the Skyrme model for the unified theory of pions and nucleons. PMID- 9959299 TI - Search for diquark clustering in baryons. PMID- 9959300 TI - Substructure of the strongly interacting Higgs sector. PMID- 9959302 TI - Meson properties at finite density from SU(3)f quark dynamics. PMID- 9959301 TI - Slightly massive photon. PMID- 9959303 TI - Nonlinear distortions of rotating chiral solitons. PMID- 9959304 TI - Aspects of the chiral quark model. PMID- 9959305 TI - ? PMID- 9959306 TI - Do all gauge interactions have a universal coupling? PMID- 9959307 TI - Do we understand Ds+--> eta pi + and Ds+--> eta ' pi +? PMID- 9959309 TI - B0B-bar 0 mixing signal from B0 and Bs0 meson production between the Upsilon (4S) and Upsilon (6S). PMID- 9959308 TI - Search for W-->cs-bar, Z-->cc-bar,bb-bar in muon-jet events at the CERN proton antiproton collider. PMID- 9959310 TI - Photon-cloud effects on isomultiplet mass differences of charmed and uncharmed baryons. PMID- 9959312 TI - Minimal model of spontaneous T-invariance violation with an invisible axion. PMID- 9959311 TI - Thermal expansion and critical temperature in a geometric representation of quark deconfinement. PMID- 9959314 TI - Spin structure functions and gluon exchange. PMID- 9959313 TI - Erratum: Superheavy-quarkonium production and decays: A new Higgs-boson signal PMID- 9959315 TI - Constraints on left-right-symmetric models from neutron decay. PMID- 9959317 TI - New bounds on neutrino magnetic moments from stellar collapse. PMID- 9959316 TI - Relativistic effects in local inertial frames including parametrized-post Newtonian effects. PMID- 9959319 TI - General-relativistic radiation hydrodynamics and neutrino transport in polar sliced space-time. PMID- 9959318 TI - Anomalous propagation of neutrino beams through dense media. PMID- 9959320 TI - Zero modes and anomalies in superconducting strings. PMID- 9959321 TI - Dynamical cosmic strings from a gauge theory of gravity. PMID- 9959323 TI - Singularities in the collisions of almost-plane gravitational waves. PMID- 9959322 TI - Structure of the singularities produced by colliding plane waves. PMID- 9959324 TI - Some new cosmological results of quadratic Lagrangians. PMID- 9959326 TI - Wave packets in minisuperspace. PMID- 9959325 TI - Einstein equivalence principle and theories of gravitation: A gravitationally modified standard model. PMID- 9959327 TI - Particle number and random phases. PMID- 9959328 TI - Quasiboson excitation spectrum of the relativistic quantum scalar plasma in the Hartree-Vlasov approximation. PMID- 9959330 TI - Quantum probability distributions in the early Universe. III. A geometric representation of stochastic systems. PMID- 9959329 TI - Baryogenesis from a Chern-Simons condensate. PMID- 9959331 TI - Scalar and spinor Casimir energies in even-dimensional Kaluza-Klein spaces of the form M4 x SN1 x SN2 x PMID- 9959332 TI - Tachyons and perturbative unitarity. PMID- 9959333 TI - Quantized strings on Riemann surfaces and the string-field-theory vertex. PMID- 9959335 TI - Symmetry behavior in the Einstein universe: Gaussian approximation in the Schrodinger picture. PMID- 9959334 TI - New formulas for the arbitrary four-point amplitudes in open-string theory. PMID- 9959337 TI - Geometric quantum phase and angles. PMID- 9959336 TI - Supersymmetry anomaly in ten dimensions. PMID- 9959338 TI - Covariant operators and the classical limit of the Dirac equation with a color field. PMID- 9959339 TI - Global gauge anomaly and James numbers of Stiefel manifolds. PMID- 9959340 TI - New approach to one-loop calculations in gauge theories. PMID- 9959341 TI - Mechanisms of spontaneous symmetry breaking in the fermionic construction of superstring models. PMID- 9959342 TI - Off-diagonal long-range order in a monopole-fermion system. PMID- 9959343 TI - Instabilities of the chiral-symmetry-breaking ground state in a truncation-free expansion. PMID- 9959344 TI - Chiral-symmetry breaking in dual QCD. PMID- 9959345 TI - From baglike models to the large-Nc limit via the Abelian projection. PMID- 9959346 TI - Static minimum-energy path from a vacuum to a sphaleron in the Weinberg-Salam model. PMID- 9959347 TI - Methods of extrapolating the t-expansion series. PMID- 9959348 TI - Critical exponents of SU(2) gauge theory in 2+1 dimensions. PMID- 9959349 TI - Masses in periodic QED. PMID- 9959350 TI - Gauge invariance on a momentum-space lattice. PMID- 9959351 TI - Finite-temperature phase transitions in lattice QCD with Langevin simulation. PMID- 9959352 TI - Parametrization of SU(3). PMID- 9959353 TI - Chiral symmetry at finite temperatures and densities in the Coulomb gauge. PMID- 9959354 TI - What will the 98Mo solar-neutrino experiment measure? PMID- 9959355 TI - Generalization of the Fortuin-Kasteleyn-Swendsen-Wang representation and Monte Carlo algorithm. PMID- 9959356 TI - Erratum: Study of correlations in fermionic matter PMID- 9959357 TI - Can neutrinos be the galactic missing mass? PMID- 9959358 TI - Antiproton-proton annihilation at rest into pi 0M and gamma M with M= phi, eta ', omega, rho 0, eta, and pi 0. PMID- 9959359 TI - Neutrino production by 400-GeV/c protons in a beam-dump experiment. PMID- 9959360 TI - High-precision measurement of polarized- Sigma - beta decay. PMID- 9959361 TI - Search for rare muon decays with the Crystal Box detector. PMID- 9959362 TI - Search for muon-electron and muon-positron conversion. PMID- 9959364 TI - New approach to test the hypothesis of compositeness. PMID- 9959363 TI - New searches for the C-noninvariant decay pi 0-->3 gamma and the rare decay pi 0- >4 gamma. PMID- 9959365 TI - Supersymmetric jets from toponium decay. PMID- 9959366 TI - S-wave squarkonium production in e+e- collisions via superstring Yukawa couplings. PMID- 9959367 TI - Phenomenology of a horizontal gauge boson in e+e- collisions. PMID- 9959368 TI - Searching for charged Higgs bosons at ~(1/2-1-TeV e+e- colliders. PMID- 9959369 TI - Quark production rule in e+e--->two jets. PMID- 9959370 TI - New low-energy theorems in nucleon Compton scattering. PMID- 9959371 TI - Polarizations and spin correlations in the NN-->N Delta reaction. PMID- 9959372 TI - pi - pi scattering and chiral Lagrangians. PMID- 9959373 TI - Scaling and correlations of squeezed coherent distributions: Application to hadronic multiplicities. PMID- 9959374 TI - Multiplicity distributions and Bose-Einstein correlations in high-energy multiparticle production in the presence of squeezed coherent states. PMID- 9959376 TI - Natural seesaw mechanism, eV-keV-MeV-type neutrino spectrum, and cosmology. PMID- 9959375 TI - Radiative corrections to tau -->V+ nu tau decay. PMID- 9959378 TI - Modification of the equivalence theorem due to loop corrections. PMID- 9959377 TI - Fermion mass matrix, horizontal CP violation, and natural flavor conservation in electroweak theories with horizontal flavor chirality. PMID- 9959379 TI - Hadron masses with two quark flavors. PMID- 9959380 TI - Studies of confinement: How quarks and gluons propagate. PMID- 9959381 TI - Muon-induced radioactivity in underground detectors. PMID- 9959382 TI - Process-independent radiative-correction formula for single-tag and double-tag measurements of gamma gamma reactions. PMID- 9959383 TI - Role of chiral scalar and pseudoscalar in two-photon production of a superlight gravitino. PMID- 9959385 TI - Decay of the loosely bound or resonant Lambda Lambda -bar state and comparison with recent experimental data. PMID- 9959384 TI - Semi-inclusive rapidity distributions from entropy maximization. PMID- 9959386 TI - Wolfenstein-type parametrization of the quark mixing matrix. PMID- 9959387 TI - Dynamical chiral-symmetry breaking and exotic quark representations. PMID- 9959388 TI - Erratum: Next-to-leading-order contributions to R= sigma L/ sigma T in QCD PMID- 9959389 TI - Production prospects for Higgs bosons in chiral-color models. PMID- 9959390 TI - Probing gamma WW couplings through pp-bar-->W gamma X at the Fermilab Tevatron. PMID- 9959392 TI - Recycling in laser-interferometric gravitational-wave detectors. PMID- 9959391 TI - Lower bound on the Higgs-boson mass with a heavy top quark. PMID- 9959394 TI - Effect of finite mass on gravitational transit time. PMID- 9959393 TI - Multimode resonant gravitational-wave antennas: How many modes is enough? PMID- 9959395 TI - Numerical rates for nucleon-nucleon, axion bremsstrahlung. PMID- 9959396 TI - Gravitational radiation from type-II supernovae: The effect of the high-density equation of state. PMID- 9959397 TI - Cross sections, relic abundance, and detection rates for neutralino dark matter. PMID- 9959398 TI - Stability of boson stars. PMID- 9959399 TI - Stochastic inflation and superstring models. PMID- 9959401 TI - Expressions for linearized perturbations in ideal-fluid cosmological models. PMID- 9959400 TI - Probability of Bianchi type-I inflation. PMID- 9959402 TI - Solution of the Einstein-Strauss problem with a Lambda term. PMID- 9959403 TI - Harmonic synchronizations of spacetime. PMID- 9959404 TI - Symmetry behavior in cosmological spacetimes: Effect of slowly varying background fields. PMID- 9959406 TI - Black holes in string-generated gravity models. PMID- 9959405 TI - Black-hole thermodynamics in Lovelock gravity. PMID- 9959408 TI - Invariant path integration and the covariant functional measure for Einstein gravitation theory. PMID- 9959407 TI - Response of accelerated detectors in coherent states and the semiclassical limit. PMID- 9959409 TI - Derivation of the Wheeler-DeWitt equation from a path integral for minisuperspace models. PMID- 9959410 TI - Central charge, trace and gravitational anomalies in two dimensions. PMID- 9959411 TI - Grassmannian Kaluza-Klein theory and the standard model. PMID- 9959412 TI - BRST-invariant N-superstring vertices. PMID- 9959413 TI - Optimized expansion in quantum field theory of massive fermions with ( psi -bar psi )2 interaction. PMID- 9959415 TI - New nonperturbative calculation: Renormalization and the triviality of ( lambda phi4)4 field theory. PMID- 9959414 TI - Feynman rules for the delta expansion. PMID- 9959416 TI - Chiral anomalies and point-splitting regularization. PMID- 9959417 TI - Functional derivatives, Green's functions, and effective potentials on the Hamiltonian lattice. PMID- 9959418 TI - Energy-momentum tensor in scalar QED. PMID- 9959419 TI - Renormalization of Yang-Mills theories in axial gauges within a uniform prescription. PMID- 9959420 TI - Non-Abelian gauge couplings at finite temperature in the general covariant gauge. PMID- 9959421 TI - BRS and anti-BRS symmetries in the planar gauge. PMID- 9959422 TI - BRS analysis of the non-Abelian chiral Schwinger model. PMID- 9959423 TI - Exact ground state, mass gap, and string tension in lattice gauge theory. PMID- 9959424 TI - Weak-coupling analysis of chiral gauge theories on a lattice. PMID- 9959425 TI - Massive fermions in the non-Abelian vortex field. PMID- 9959426 TI - QED on a circle. PMID- 9959427 TI - Symmetry restoration of scalar models at finite temperature. PMID- 9959428 TI - Testing the principle of equivalence with neutrino oscillations. PMID- 9959429 TI - Chiral bosonization and vanishing of the three-point amplitude at two loops in the heterotic string. PMID- 9959430 TI - Effective potential versus bosonization. PMID- 9959431 TI - Dispersion relation of the pion in the Nambu-Jona-Lasinio model. PMID- 9959432 TI - Two-body Dirac equation with a scalar linear potential. PMID- 9959433 TI - Erratum: Forced harmonic oscillator with damping and thermal effects PMID- 9959434 TI - Fujikawa-type formulation of gauged BRST symmetry for the free bosonic string. PMID- 9959435 TI - Canonical analysis of the one-parameter teleparallel theory. PMID- 9959436 TI - Electroweak studies in e+e- collisions: 12< sqrt s<46.78 GeV. PMID- 9959437 TI - Investigation of the total charm-pair cross section in nonresonant e+e- annihilations at sqrt s =10.5 GeV. PMID- 9959440 TI - Study of hadronic J/ psi decays involving phi and omega production. PMID- 9959439 TI - Measurements of J/ psi decays into a vector and a pseudoscalar meson. PMID- 9959438 TI - Comparison of low-PT photon production in high- and low-multiplicity collisions at the CERN ISR. PMID- 9959442 TI - Implications of the Chou-Yang model for e+e--->hh-bar. PMID- 9959441 TI - Pair decay of the 2.2-MeV excited state of the deuteron: Limits on light-particle emission. PMID- 9959443 TI - Strategies to search for the standard-model Higgs boson at a 1-TeV e+e- collider. PMID- 9959445 TI - Neutrino tridents, conserved vector current, and partially conserved axial-vector current. PMID- 9959444 TI - Tests of compositeness at e+e- colliders. PMID- 9959446 TI - Neutrino reactions in the low-y region. PMID- 9959447 TI - Distribution amplitudes and electroproduction of the delta and other low-lying resonances. PMID- 9959448 TI - Double Higgs-boson bremsstrahlung from W and Z bosons at supercolliders. PMID- 9959449 TI - Comparison of exact and effective-gauge-boson calculations for gauge-boson fusion processes. PMID- 9959450 TI - b-quark production and dilepton cross sections at hadron colliders. PMID- 9959452 TI - Creation of strange-quark-matter droplets as a unique signature for quark-gluon plasma formation in relativistic heavy-ion collisions. PMID- 9959453 TI - Muon pairs and photon pairs as signals for the hadronization phase transition at finite baryon density. PMID- 9959451 TI - A dependence of quarkonium production in proton-nucleus collisions. PMID- 9959454 TI - Dilepton production at finite temperature: Perturbative treatment at order alpha s. PMID- 9959455 TI - Cosmic neutrino beams: Probes of lepton and quark substructure. PMID- 9959456 TI - KL--> microe in SU(2)L x U(1) and SU(2)L x SU(2)R x U(1) models with large neutrino masses. PMID- 9959457 TI - One-loop two-particle scalar-top-quark decay. PMID- 9959458 TI - Charged-Higgs-boson effect in Bd0-B-bard0 mixing, K--> pi nu nu -bar decay, and rare decays of B mesons. PMID- 9959460 TI - Chiral symmetry and the Higgs-boson-nucleon coupling. PMID- 9959459 TI - Neutrino masses and the Voloshin-Vysotsky-Okun solution to the solar-neutrino problem. PMID- 9959461 TI - Fermion mass hierarchy without flavor-changing neutral currents in a technicolor model. PMID- 9959462 TI - Modified Skyrme model with correct QCD scaling behavior on S3. PMID- 9959463 TI - Fermion-number susceptibility in lattice gauge theory. PMID- 9959464 TI - Exponentiation of soft photons in Monte Carlo event generators: The case of the Bonneau-Martin cross section. PMID- 9959465 TI - Further contributions to the radiative corrections to the beta energy spectrum in charged-hyperon semileptonic decays. PMID- 9959466 TI - Calculation of low-energy atmospheric muon flux. PMID- 9959467 TI - Analytic treatment of high-order adiabatic approximations of two-neutrino oscillations in matter. PMID- 9959469 TI - Erratum: Detecting the radiation amplitude zero in e+/-p-->e+/-p gamma PMID- 9959468 TI - Comment on "A peculiar relation between mass and energy with respect to the Schrodinger equation" PMID- 9959470 TI - Search for the decays KL0--> microe and KL0-->ee. PMID- 9959471 TI - Bose-Einstein correlations in e+e- collisions. PMID- 9959472 TI - Measurement of the reaction K+n PMID- 9959474 TI - Central collisions of 800-GeV protons with Ag/Br nuclei in nuclear emulsion. PMID- 9959473 TI - Acceleration of polarized protons to 22 GeV/c and the measurement of spin-spin effects in p PMID- 9959475 TI - Experimental study of muon pairs produced by 252-GeV pions on tungsten. PMID- 9959476 TI - Measurement of the D0, D+, and Ds+ meson lifetimes. PMID- 9959477 TI - Analytical studies on single W- and Z-boson production in electron-positron collisions. PMID- 9959478 TI - WWZ, ZZZ, and WW gamma production at e+e- colliders. PMID- 9959480 TI - Signatures of an extra Z0 gauge boson in elastic e--proton scattering. PMID- 9959479 TI - Double-cascade scheme for QCD jets in e+e- annihilation. PMID- 9959482 TI - Geometrical branching model: Phenomenology with jets. PMID- 9959481 TI - Measuring the parton content of the photon at the DESY ep collider HERA. PMID- 9959484 TI - Energy fraction of the central region in the Chou-Yang model. PMID- 9959483 TI - Effect of jet production on the multiplicity dependence of average transverse momentum. PMID- 9959485 TI - Forward-backward multiplicity distributions in a pure-birth process. PMID- 9959487 TI - Fourth-generation-quark production at the Superconducting Super Collider. PMID- 9959486 TI - Lepton-pair production in proton-nucleon collisions as a means of testing the standard electroweak model. PMID- 9959488 TI - On the fate of a J/ psi produced in a nucleus-nucleus collision. PMID- 9959489 TI - B--> micro+ micro- in the two-Higgs-doublet model. PMID- 9959490 TI - Spectra of the transitions Upsilon (nS)--> Upsilon (mS) pi + pi - PMID- 9959492 TI - Application of the bootstrap statistical method to the tau-decay-mode problem. PMID- 9959491 TI - Analysis of muon decay with lepton-number-nonconserving interactions. PMID- 9959493 TI - Can flavor-changing Z decay provide a test for supersymmetry? PMID- 9959494 TI - Effective electromagnetic form factor of the neutrino. PMID- 9959495 TI - Issues in QCD and properties of the Upsilon system. PMID- 9959496 TI - Baryonic properties of broken U(3)V Skyrmions. PMID- 9959497 TI - Gravity-induced large grand-unification mass in SU(5) with higher-dimensional operators. PMID- 9959498 TI - Chiral-symmetry constraints on the critical temperature in QCD. PMID- 9959499 TI - Debye length in an expanding quark-gluon plasma. PMID- 9959500 TI - Resonant pair production in strong electric fields. PMID- 9959501 TI - Possible new phase of QED from correlated narrow-peak structures observed in heavy-ion collisions. PMID- 9959502 TI - Role of the pion size and flux-tube extension in a baryon-decay model. PMID- 9959503 TI - Exact solution of a class of two-state periodic Schrodinger problems. PMID- 9959504 TI - Seesaw fermion masses in the standard model. PMID- 9959505 TI - Wess-Zumino-type effective action for technions with light gauge bosons in a chiral-anomaly technicolor model. PMID- 9959506 TI - Lattice vacuum corrections in the flux-tube model. PMID- 9959507 TI - Orbital angular momentum, spin fractions, and scenarios for the proton's spin weighted parton distributions. PMID- 9959508 TI - Motivation and technique for light-Higgs-boson search. PMID- 9959509 TI - Detection of the gravitomagnetic field using an orbiting superconducting gravity gradiometer. Theoretical principles. PMID- 9959511 TI - Inflation in a renormalizable cosmological model and the cosmic no-hair conjecture. PMID- 9959510 TI - Potential flows in general relativity: Some exact solutions. PMID- 9959512 TI - Extended inflation with induced gravity. PMID- 9959513 TI - Turning on a superconducting cosmic string. PMID- 9959515 TI - Consistency of quantum cosmology for models of plane symmetry. PMID- 9959514 TI - Exact Langevin equation in a cosmological setting. PMID- 9959516 TI - Analysis of spatially inhomogeneous perturbations of the FRW cosmologies. PMID- 9959518 TI - Dray-'t Hooft geometries and the death of white holes. PMID- 9959517 TI - Neutron diffusion and nucleosynthesis in the Universe with isothermal fluctuations produced by quark-hadron phase transition. PMID- 9959519 TI - General static axisymmetric solution of Einstein's vacuum field equations in prolate spheroidal coordinates. PMID- 9959520 TI - Decoherence in quantum cosmology. PMID- 9959521 TI - Decoherence in the density matrix describing quantum three-geometries and the emergence of classical spacetime. PMID- 9959522 TI - 3+1 formulation of general-relativistic perfect magnetohydrodynamics. PMID- 9959523 TI - Quantum limited detectors for weak classical signals. PMID- 9959524 TI - Curvature fluctuations in maximally symmetric spaces. PMID- 9959525 TI - Magnetic-induced vacuum instability in de Sitter spacetime. PMID- 9959526 TI - Maximal supergravities in SU(8/1). PMID- 9959527 TI - Extended Sugawara construction for the superalgebras SU(M+1||N+1). I. Free-field representation and bosonization of super Kac-Moody currents. PMID- 9959529 TI - Spin-2 gravitational trace anomaly. PMID- 9959528 TI - Non-Abelian anomalies on a curved space with torsion. PMID- 9959530 TI - Variational calculations and Bogolubov transformations. PMID- 9959531 TI - Some connections between classical and quantum anholonomy. PMID- 9959532 TI - Symmetry in string theory. PMID- 9959534 TI - Variational study of the Gross-Neveu model. PMID- 9959533 TI - Parity-violating one-loop function in lower-dimensional type-I string theory. PMID- 9959536 TI - Path-integral bosonization for a nonrenormalizable axial four-dimensional fermion model. PMID- 9959535 TI - Renormalization of the delta expansion of lambda ( phi2+2 delta )2 theory. PMID- 9959537 TI - Quantum geometry of chiral bosons on a circle. PMID- 9959538 TI - Mass-induced transition in fermion number. PMID- 9959539 TI - Two-loop effective potential of supersymmetric quantum electrodynamics. PMID- 9959540 TI - Higgs coupling and the decoupling theorem. PMID- 9959541 TI - Thermodynamics of (2+1)-dimensional four-fermion models. PMID- 9959542 TI - Zero modes of the vortex-fermion system: The non-Abelian case. PMID- 9959543 TI - Non-Abelian chiral gauge theories in two dimensions. PMID- 9959545 TI - Stability of spontaneous symmetry breaking in a class of SO(10) models. PMID- 9959544 TI - Restrictions on the applicability of zeta -function regularization in gauge theories. PMID- 9959546 TI - Interpreting four-quark interactions in finite-temperature, SU(2), lattice gauge theory. PMID- 9959547 TI - Loop calculus for lattice gauge theories. PMID- 9959548 TI - Analytic approach to phase transitions and observables in Abelian gauge theories. PMID- 9959550 TI - Geodesic motion in a Kaluza-Klein bubble spacetime. PMID- 9959549 TI - Universality and mass gaps for a series of lattice Hamiltonians with exact ground states. PMID- 9959552 TI - Towards the Einstein-Hilbert action via conformal transformation. PMID- 9959551 TI - Perfect-fluid higher-dimensional cosmologies. II. PMID- 9959554 TI - Preconditioning the Kogut-Susskind fermion matrix. PMID- 9959553 TI - Genus-two characters of the Ising model. PMID- 9959555 TI - Cooling as a method of finding topological dislocations in lattice models. PMID- 9959556 TI - Comment on "Quantum cosmology and the initial state of the Universe" PMID- 9959557 TI - Comment on a paper by Rindani and Sivakumar. PMID- 9959559 TI - Role of the noncanonical transformation in anomalous gauge theories. PMID- 9959558 TI - Comment on "Exact ground state, mass gap, and string tension in lattice gauge theory" PMID- 9959561 TI - Traversable wormholes: Some simple examples. PMID- 9959560 TI - Erratum: Energy-momentum tensor in scalar QED PMID- 9959563 TI - Neutrino-electron scattering and the choice between different Mikheyev-Smirnov Wolfenstein solutions of the solar neutrino problem. PMID- 9959562 TI - Axion dynamics in wormhole background. PMID- 9959564 TI - Quantum jumps, geodesics, and the topological phase. PMID- 9959565 TI - Gauge-invariant correlation functions. PMID- 9959566 TI - Search for the anomalous production of single photons in e+e- annihilation at sqrt s =29 GeV. PMID- 9959568 TI - Phenomenology of single-W production in e gamma collisions. PMID- 9959567 TI - eta and eta ' production in p-barp annihilation at rest. PMID- 9959569 TI - Strange-quark vector currents and parity-violating electron scattering from the nucleon and from nuclei. PMID- 9959570 TI - Quark spin and momentum distributions of the nucleon. PMID- 9959571 TI - The reaction gamma gamma --> pi pi at low energy. PMID- 9959572 TI - Does string fragmentation reveal more than longitudinal phase space? PMID- 9959573 TI - Gluon content of the nucleon probed with real and virtual photons. PMID- 9959574 TI - Effects of initial-state QCD interactions in the Drell-Yan process. PMID- 9959575 TI - Aspects of top-quark searches in TeV hadron collisions. PMID- 9959576 TI - Search for top-quark decays to real W bosons at the Fermilab Tevatron collider. PMID- 9959577 TI - CP-violating decay KL0--> pi 0 nu nu -bar. PMID- 9959578 TI - Long-distance contributions to the decay K+--> pi + nu nu -bar. PMID- 9959579 TI - Study of CP violation and light Higgs bosons with muon polarization asymmetry in KL0--> micro micro-bar decay. PMID- 9959580 TI - Angular correlations in the decay B-->VV and CP violation. PMID- 9959581 TI - SU(3) predictions for nonleptonic B-meson decays. PMID- 9959582 TI - tau -->(3 pi ) nu tau and light-meson spectroscopy. PMID- 9959583 TI - QCD effects in the B0-B-bar 0 system. PMID- 9959584 TI - Neutrino electromagnetic form factors. PMID- 9959585 TI - Electromagnetic charge radii of pseudoscalar mesons. PMID- 9959586 TI - Hyperon resonances in the chiral bag model. PMID- 9959587 TI - Implications of, constraints on, and signatures of a fourth-generation lepton triplet. PMID- 9959588 TI - Structure of exotic generations. PMID- 9959589 TI - Model-independent analysis of quark mass matrices. PMID- 9959590 TI - New parametrization of the Kobayashi-Maskawa matrix and its implications. PMID- 9959592 TI - Detailed estimations of the contributions to Delta B=2 effective Hamiltonian in supersymmetric models. PMID- 9959591 TI - Nearest-neighbor interactions and the physical content of Fritzsch mass matrices. PMID- 9959593 TI - Dynamical excited weak bosons and their observable signatures. PMID- 9959594 TI - CP violation in the two-generation version of left-right models. PMID- 9959596 TI - Addendum to "Production of flavor-changing gauge bosons from E6 at e+e- and hadron colliders": Single production in e+e- annihilation. PMID- 9959595 TI - Chiral-symmetry restoration in the Nambu-Jona-Lasinio model with a constant electromagnetic field. PMID- 9959597 TI - Radiative muon capture in hydrogen and nucleon excitation. PMID- 9959599 TI - Extraction of ||Vub/Vcb|| from nonleptonic-B-meson-decay data. PMID- 9959598 TI - Coupled-channel effects in the decay Upsilon (3S)--> Upsilon (1S) pi + pi - PMID- 9959600 TI - Will the observation of Ds+--> omega pi + be a signal for the annihilation mechanism? PMID- 9959601 TI - W-boson electric dipole moment and helicity amplitudes. PMID- 9959603 TI - Comment on "Slightly massive photon" PMID- 9959602 TI - Singlet dilambda in the chiral theory. PMID- 9959604 TI - Erratum: Asymmetry between inclusive charmed and anticharmed modes in B0, B-bar 0 decay as a measure of CP violation PMID- 9959605 TI - High-resolution measurement of massive-dielectron production in 800-GeV proton beryllium collisions. PMID- 9959606 TI - Spin-correlation parameter Ann( theta ) for n-p elastic scattering at 790 MeV. PMID- 9959607 TI - Search for a fourth-generation quark with ||Q||=e/3 in e+e- collisions at sqrt s =56-57 GeV. PMID- 9959608 TI - Measurement of the muonic branching fractions of the Upsilon (1S) and Upsilon (3S). PMID- 9959609 TI - Flux of atmospheric neutrinos. PMID- 9959610 TI - Neutrino oscillations and uncertainty in the solar model. PMID- 9959612 TI - Formation of topological defects in phase transitions. PMID- 9959611 TI - Annihilation of heavy-neutral-fermion pairs into monochromatic gamma rays and its astrophysical implications. PMID- 9959613 TI - Analytic solution of a chaotic inflaton. PMID- 9959614 TI - General-relativistic domain walls. PMID- 9959615 TI - Collapse of nearly spherical domain walls. PMID- 9959616 TI - Evolution and classification of cosmological perturbations. PMID- 9959617 TI - Symmetry and singularity formation in expanding spacetimes. PMID- 9959618 TI - Statistics from dynamics in curved spacetime. PMID- 9959619 TI - Experimental constraints on a minimal and nonminimal violation of the equivalence principle in the oscillations of massive neutrinos. PMID- 9959620 TI - Magnetic field induced by vacuum polarization in de Sitter spacetime. PMID- 9959621 TI - Is the Einstein theory a low-energy phenomenological limit? PMID- 9959622 TI - Regularization of two-dimensional quantum gravity. PMID- 9959623 TI - Quantum probability distributions in the early Universe. IV. Stochastic dynamics in de Sitter space. PMID- 9959625 TI - Infrared behavior of quasilocal systems at finite temperature. PMID- 9959624 TI - Bosonic zero-frequency modes and initial conditions. PMID- 9959627 TI - Regularization of the path-integral measure for anomalies. PMID- 9959628 TI - The delta expansion for stochastic quantization. PMID- 9959626 TI - Finite quantum field theory based on superspin fields. PMID- 9959630 TI - Conformal properties of the superstring-ghost Thirring model: Short-distance structure and bosonization. PMID- 9959629 TI - Quantum theory of nonlocal magnetic-monopole fields. PMID- 9959632 TI - Search for four-dimensional string models. PMID- 9959631 TI - Neveu-Schwarz-Ramond open-superstring field theory at finite temperature. PMID- 9959634 TI - Problem of changing gauge in Polyakov's theory: Relation between light-cone and conformal gauges. PMID- 9959633 TI - Genus-2 free energy of the closed bosonic string. PMID- 9959635 TI - Effective one-loop Lagrangian for gauged scrH/scrK sigma models. PMID- 9959637 TI - Stochastic truncation method for Hamiltonian lattice field theory. PMID- 9959636 TI - Equivalence of the massive Thirring model with a U(1) gauge theory. PMID- 9959639 TI - < phi2> for massive fields in Schwarzschild spacetime. PMID- 9959638 TI - Hamiltonian Monte Carlo calculations on (2+1)-dimensional QED. PMID- 9959640 TI - Nonperturbative stability analysis of quantum-field-theory models. PMID- 9959641 TI - Self-dual fields and causality. PMID- 9959642 TI - Finiteness of the bosonic string in fewer than 26 dimensions. PMID- 9959644 TI - Erratum: Cross sections, relic abundance, and detection rates for neutralino dark matter PMID- 9959643 TI - Calculation of the electron magnetic moment in Fried-Yennie-gauge QED. PMID- 9959645 TI - Bulk viscosity of hot neutron-star matter and the maximum rotation rates of neutron stars. PMID- 9959646 TI - Cosmic-string-loop fragmentation. PMID- 9959648 TI - Particle creation in inhomogeneous spacetimes. PMID- 9959647 TI - Electromagnetic self-interaction of superconducting cosmic strings. PMID- 9959649 TI - Chaotic inflationary scenario of the Universe with a nonminimally coupled "inflaton" field. PMID- 9959650 TI - Behavior of chaotic inflation in anisotropic cosmologies with nonminimal coupling. PMID- 9959651 TI - Mechanism for current generation in strings and internal phase transitions in strings. PMID- 9959652 TI - Cosmological solution of Einstein's equations with uniform density and nonuniform pressure. PMID- 9959653 TI - Some solutions in Einstein-Kalb-Ramond cosmology. PMID- 9959654 TI - Reduction of Einstein's equations for nonstationary cylindrical cosmic strings. PMID- 9959655 TI - Derivation of Ashtekar variables from tetrad gravity. PMID- 9959656 TI - Schrodinger-picture field theory in Robertson-Walker flat spacetimes. PMID- 9959658 TI - Two-dimensional quantum cosmology: Directions of dynamical and thermodynamic arrows of time. PMID- 9959657 TI - Properties of the wormhole calculus. PMID- 9959659 TI - Curvature-singularity-free solutions for colliding plane gravitational waves with broken u-v symmetry. PMID- 9959660 TI - Cosmions in the nonsymmetric gravitational theory. PMID- 9959661 TI - New perturbative approximation applied to a self-interacting scalar field theory. PMID- 9959662 TI - Dirac quantization of the vector superfield. PMID- 9959663 TI - Variational basis-state expansion calculation of the mass gap in scalar field theory. PMID- 9959665 TI - Absence of (1,0) supersymmetry anomaly in world-sheet gauge theories: A purely cohomological proof. PMID- 9959664 TI - Covariant BRS quantization of the ten-dimensional N=1 Brink-Schwarz superparticle. PMID- 9959667 TI - Closed strings from open bosonic strings. PMID- 9959666 TI - Dynamical supersymmetry breaking due to vacuum tunneling. PMID- 9959668 TI - Canonical quantization of closed-superstring fields. PMID- 9959670 TI - Mass splittings and the finiteness problem of mass shifts in the type-II superstring at one-loop order. PMID- 9959669 TI - Yang-Mills formulation of interacting strings. PMID- 9959672 TI - Superstring field theory with Wess-Zumino term. PMID- 9959671 TI - Two-dimensional nonlinear sigma model with N=1 and BRST quantization. PMID- 9959674 TI - Unsuppressed fermion-number violation at high temperature: An O(3) model. PMID- 9959673 TI - Geometrical origin of supersymmetric gauge theories. PMID- 9959675 TI - Casimir force on a solid ball when epsilon ( omega ) micro( omega )=1. Finite temperatures. PMID- 9959676 TI - Lower-bound renormalization group for gauge-Higgs systems. PMID- 9959677 TI - Overrelaxation and mode coupling in sigma models. PMID- 9959679 TI - Finite-temperature QCD with intermediate-large quark masses. PMID- 9959678 TI - Variational-cumulant expansion in lattice gauge theory at finite temperature. PMID- 9959681 TI - Longitudinal modes in classical Yang-Mills plasma. PMID- 9959680 TI - Singular gauge dependence of the QCD coupling constant. PMID- 9959682 TI - P- and CP-odd terms in the photon self-energy within a medium. PMID- 9959683 TI - Stability of an E field in the presence of a charged scalar field. PMID- 9959685 TI - Conformally flat initial data for general relativity in Ashtekar's variables. PMID- 9959684 TI - Three-derivatives in three dimensions. PMID- 9959686 TI - Geodesics in Kasner universes. PMID- 9959687 TI - Limits on C and P violation in gravitation from SN 1987A data. PMID- 9959688 TI - Dynamical mass generation in the Gross-Neveu model at finite temperature and density. PMID- 9959690 TI - Bosonic open-string field theory at finite temperature. PMID- 9959689 TI - Spontaneous breaking of Lorentz symmetry in string theory. PMID- 9959691 TI - Biased Monte Carlo algorithms on unitary groups. PMID- 9959692 TI - Uniqueness of quark and lepton representations in the standard model from the anomalies viewpoint. PMID- 9959693 TI - Erratum: Perfect-fluid higher-dimensional cosmologies PMID- 9959694 TI - First observation of three pseudoscalar states in J/ psi --> gamma rho rho decay. PMID- 9959695 TI - O( alpha s2) planar triple energy correlation in QCD. PMID- 9959696 TI - General amplitudes for three-gauge-boson production and cross sections and polarization analysis at an e+e- collider. PMID- 9959697 TI - Probing the WHZ vertex in E6 models at colliders. PMID- 9959699 TI - Underlying event multiplicity in jet and vector-boson production: A measure of quark and gluon spatial distributions. PMID- 9959698 TI - Detection of light standard Higgs boson in e-e+ annihilation: Collinearity-angle distributions for signal and background. PMID- 9959701 TI - Approximate multijet cross sections in QCD. PMID- 9959700 TI - Higgs-boson production from heavy-quark fusion. PMID- 9959702 TI - Short-range mechanism in the NN-->N Delta transition. PMID- 9959703 TI - Rising cross sections in QCD and the cosmic-ray data. PMID- 9959704 TI - Multiparticle production in p-p, p-Ar, and p-Xe collisions at 200 GeV by the multistring model VENUS. PMID- 9959705 TI - Unusual phenomena in the rapidity distribution and the phase transition of the quark-gluon plasma. PMID- 9959706 TI - Semileptonic B and D decays in the quark model. PMID- 9959707 TI - CP asymmetries in charmless baryonic decays of charged B mesons. PMID- 9959708 TI - B-->B gamma decays in a bag model for heavy-light-quark states. PMID- 9959709 TI - Are there really any experimental limits on a light Higgs boson? PMID- 9959710 TI - Partial-wave unitarity constraints on the axigluon mass. PMID- 9959711 TI - Deuteron as a toroidal Skyrmion: Electromagnetic form factors. PMID- 9959712 TI - Higgs bosons in a nonminimal supersymmetric model. PMID- 9959714 TI - Current-quark masses from a relativistic constituent-quark model. PMID- 9959713 TI - Mass limits on scalar bosons in left-right-symmetric models. PMID- 9959716 TI - QCD-based effective Lagrangian including quark mass effects: Calculation of fK. PMID- 9959715 TI - Flavor-changing neutral currents and seesaw masses for quarks. PMID- 9959718 TI - Effect of the third generation on the analysis of neutrino-oscillation experiments. PMID- 9959717 TI - Properties of hadrons in lattice quantum chromodynamics with dynamical Wilson fermions. PMID- 9959719 TI - New heavy-quark physics in the strongly Yukawa-coupled standard model. PMID- 9959720 TI - Introducing thermal excitations for color potentials. PMID- 9959721 TI - Color-singlet quark-pair transmutation: Helicity amplitudes and partial-wave analysis. PMID- 9959722 TI - Long-distance behavior of quark form factor in QCD. PMID- 9959723 TI - High-frequency limit of the longitudinal impedance of an array of cavities. PMID- 9959724 TI - Techniomega production in pp colliders. PMID- 9959725 TI - Nonsingular potential model for heavy quarkonia. PMID- 9959726 TI - Lattice heavy-meson decay constants and fermion universality. PMID- 9959728 TI - Comment on "Constraints on the Majoron interactions from the supernova SN1987A" PMID- 9959727 TI - Parity-invariant solution in the B=2 sector of the SU(3)F Skyrme model. PMID- 9959730 TI - Reply to "Comment on Jarlskog's conditions for CP invariance" PMID- 9959729 TI - Comment on Jarlskog's conditions for CP invariance. PMID- 9959731 TI - Erratum: Model dependence of the chargino mass bound from the CERN collider data PMID- 9959732 TI - Limit on the decay KL0--> microe. PMID- 9959733 TI - It=Jt rule in action. PMID- 9959734 TI - Quantum stabilization of the Skyrme soliton. PMID- 9959735 TI - Self-consistent nonperturbative effect of string fragmentation on superstring mass spectra. PMID- 9959736 TI - Collisional incoherence in neutrino line emission. PMID- 9959737 TI - The case for neutrinos from SN 1987A. PMID- 9959738 TI - Axions and SN 1987A. PMID- 9959740 TI - Effect of small-scale baryon inhomogeneity on cosmic nucleosynthesis. PMID- 9959739 TI - Probing the Earth with weakly interacting massive particles. PMID- 9959741 TI - Astrophysical treatment of intermediate-range forces. PMID- 9959743 TI - Quantum instability of gravitational collapse in de Sitter space. PMID- 9959742 TI - Formation of a "child" universe in an inflationary cosmological model. PMID- 9959745 TI - Gravitational fields of straight and circular cosmic strings: Relation between gravitational mass, angular deficit, and internal structure. PMID- 9959744 TI - Particle creation due to cosmological contraction of extra dimensions. PMID- 9959746 TI - Pseudo-Riemannian geometry on a simplicial lattice and the extrinsic curvature tensor. PMID- 9959748 TI - Interpretation of the wave function of the Universe. PMID- 9959747 TI - Proof of the quantum bound on specific entropy for free fields. PMID- 9959749 TI - Quantum field theory of the Universe. PMID- 9959750 TI - Renormalized electromagnetic stress tensor in Schwarzschild spacetime. PMID- 9959751 TI - Improved integral representation for the finite-temperature propagator in string theory. PMID- 9959752 TI - New p-adic strings from old dual models. PMID- 9959754 TI - Gaussian-improved one-loop effective potential. PMID- 9959753 TI - Siegel's superparticle. PMID- 9959755 TI - Gauge superfield in six dimensions. PMID- 9959756 TI - Simple proof of Weil triviality in supersymmetric gauge theories. PMID- 9959757 TI - BRST quantization of the CP1 model with Chern-Simons term in 2+1 dimensions. PMID- 9959758 TI - Conservation laws, Korteweg-de Vries and sine-Gordon systems, and the role of supersymmetry. PMID- 9959759 TI - Radiative symmetry breaking in (2+1)-dimensional space. PMID- 9959760 TI - Symmetry breaking by Wilson loops in gauge field theory. PMID- 9959761 TI - Symplectic structure of Yang-Mills theory in BRST formalism. PMID- 9959762 TI - Quantum chromodynamics in background fields. PMID- 9959764 TI - New signatures for dark-matter detectors. PMID- 9959763 TI - Confining phase transition as monopole condensation. PMID- 9959765 TI - Limits on right-handed interactions from SN 1987A observations. PMID- 9959766 TI - Evaporation of strange matter (and similar condensed phases) at high temperatures. PMID- 9959767 TI - Conformal properties of the heat-kernel expansion. Application to the effective Lagrangian. PMID- 9959768 TI - Nonexistence of spherically symmetric monopole solutions in the three-generation superstring model. PMID- 9959769 TI - Reflectionless symmetric potentials from vertex operators. PMID- 9959770 TI - Metropolis and Langevin time. PMID- 9959771 TI - Light-front variational approach to scalar field theories. PMID- 9959772 TI - Spinor loop anomalies in higher-derivative theories. PMID- 9959774 TI - Erratum: Stability of boson stars PMID- 9959773 TI - Comment on "Functional integral for Weyl fermions and the effective action" PMID- 9959775 TI - Search for long-lived exotic particles in 12-GeV proton-nucleus interactions. PMID- 9959776 TI - Extensive air showers accompanied by gamma -ray families with PMID- 9959778 TI - Measuring CP violation in the B0B-bar0 system with asymmetric-energy e+e- beams. PMID- 9959777 TI - Abundance of primary protons at (1-3) x 10(15) eV inferred from a simulation of extensive air showers with gamma -ray families. PMID- 9959779 TI - Complete formalism for charge-symmetry tests in n-p elastic scattering. PMID- 9959780 TI - P-wave pion scattering in the Los Alamos soliton model. PMID- 9959781 TI - Muons in gamma showers. PMID- 9959782 TI - What can we understand about the muon anomalies in high-energy showers from point sources? PMID- 9959783 TI - Electron pair production from pulsed electromagnetic fields in relativistic heavy ion collisions. PMID- 9959785 TI - Tests of flavor and nonet symmetry in the decays of charmed mesons into two pseudoscalars. PMID- 9959784 TI - Predictions of the standard model for Bc+/- weak decays. PMID- 9959787 TI - The a1 in tau decay. PMID- 9959786 TI - Issue of psi --> gamma eta, gamma eta ' decays and eta - eta ' mixing. PMID- 9959788 TI - Can we improve the nu tau mass limit from the decay tau -->l nu -barl nu tau ? PMID- 9959790 TI - Higgs-boson-mediated neutrinoless double- beta decay and neutrino mass in a Majoron model. PMID- 9959789 TI - Constraints on decaying right-handed Majorana neutrinos from SN 1987A observations. PMID- 9959792 TI - Determination of phases of generalized Kobayashi-Maskawa matrix elements from their magnitudes. PMID- 9959791 TI - Quark mass matrix with family-independent quark mixing. PMID- 9959794 TI - Dynamical quark-polarization cloud around static quark sources. PMID- 9959795 TI - Quark momentum distribution of hadronic matter in a simple confining quark model. PMID- 9959793 TI - New derivation of the Altarelli-Parisi equations. PMID- 9959796 TI - Composite-meson-quark interactions under the condition of dynamical breaking of chiral symmetry. PMID- 9959797 TI - Theoretical and phenomenological studies concerning a possible new phase of QED. PMID- 9959798 TI - Flavor connections and neutrino-mass hierarchy in variant invisible-axion models without domain-wall problem. PMID- 9959799 TI - Model of exotic baryon-number nonconservation at moderate energies. PMID- 9959800 TI - Perturbative QCD corrections to the ratio R for tau decay. PMID- 9959801 TI - Resonance background to the decays b-->sl+l-, B-->Kl+l-, and B-->Kl+l- PMID- 9959802 TI - Test of optimization procedures. PMID- 9959803 TI - Model for an attractive feeble force. PMID- 9959805 TI - Erratum: Constraints on left-right-symmetric models from neutron decay PMID- 9959806 TI - rho - omega mixing and the n-p mass difference. PMID- 9959804 TI - Erratum: Charm production in nonresonant e+e- annihilations at sqrt s =10.55 GeV PMID- 9959808 TI - Possible evidence for a new particle from SN 1987A. PMID- 9959807 TI - Experimental study of upward-going muons in Kamiokande. PMID- 9959810 TI - Initial conditions for perturbations in R+ epsilon R2 cosmology. PMID- 9959809 TI - Initial conditions for R+ epsilon R2 cosmology. PMID- 9959811 TI - Cosmology with an extremely light scalar field. PMID- 9959813 TI - Gravitational nucleation of vacuum phase transitions by compact objects. PMID- 9959812 TI - Evolution of superconducting cosmic loops. PMID- 9959814 TI - Existence of global strings coupled to gravity. PMID- 9959815 TI - Contribution of gravitational self-interaction to Delta phi and micro for a cosmic string. PMID- 9959816 TI - Cosmology of biased discrete symmetry breaking. PMID- 9959817 TI - Curved-space trace, chiral, and Einstein anomalies from path integrals, using flat-space plane waves. PMID- 9959818 TI - Parametrized scalar field on openR >= 1: Dynamical pictures, spacetime diffeomorphisms, and conformal isometries. PMID- 9959819 TI - Wave mechanics and inertial guidance. PMID- 9959820 TI - Topological invariant of fermion-vortex system. PMID- 9959821 TI - Toy superstrings. PMID- 9959822 TI - More on one-loop massless amplitudes of superstring theories. PMID- 9959823 TI - Covariant Virasoro operators and free bosonic string field theory. PMID- 9959824 TI - Hidden extended superconformal symmetries in superstrings. PMID- 9959825 TI - Generalized Green-Schwarz anomaly cancellation mechanism. PMID- 9959826 TI - Nonlocal Noether currents and conformal invariance for super chiral fields. PMID- 9959827 TI - Alternative proof of Zamolodchikov's c theorem in dimensionally regularized sigma models: An operator-product-expansion analysis. PMID- 9959829 TI - Gaussian approximation of lambda phi4 theory in (3+1)-dimensional spatially flat Robertson-Walker space. PMID- 9959828 TI - Gauged Q balls. PMID- 9959830 TI - Background-field and Schwinger-DeWitt proper-time algorithm for the low-energy effective-field-theory action. PMID- 9959831 TI - Generalized Schwinger-DeWitt expansions and effective field theories. PMID- 9959832 TI - Energy-momentum tensor in theories with scalar fields and two coupling constants. I. Non-Abelian case. PMID- 9959834 TI - Energy-momentum tensor in theories with scalar fields and two coupling constants. III. A model with two scalars. PMID- 9959833 TI - Energy-momentum tensor in theories with scalar fields and two coupling constants. II. Yukawa theory. PMID- 9959835 TI - Field-parametrization dependence of the effective action in scalar electrodynamics. PMID- 9959836 TI - Meaning of anomalous commutators and descent equation in chiral gauge theories. PMID- 9959837 TI - Application of unifying prescription for axial-type gauges in QCD. PMID- 9959838 TI - Hamiltonian lattice gauge theories in a loop-dependent magnetic representation. PMID- 9959839 TI - Test of equivalence principle for neutrinos and antineutrinos. PMID- 9959841 TI - Cosmic-string loop self-intersections and intercommuting. PMID- 9959840 TI - On the delayed low-energy events in the neutrino-burst data from SN 1987A. PMID- 9959842 TI - Scalar interactions with intermediate range. PMID- 9959843 TI - Approximate stress-energy tensor for evaporating black holes. PMID- 9959844 TI - Solar-neutrino-oscillation parameters and the broken-R-parity Majoron. PMID- 9959846 TI - Normalization of bound-state solutions to the Breit equation. PMID- 9959845 TI - Dirac-bracket quantization of chiral scalar two-dimensional QED. PMID- 9959848 TI - Witten index of supersymmetric chiral theories. PMID- 9959847 TI - Higher-order discretizations and the Metropolis step. PMID- 9959849 TI - Are 't Hooft indices constrained in preon models with complementarity? PMID- 9959850 TI - Comment on the use of doubled surfaces. PMID- 9959851 TI - Limits on new-lepton pairs (L-,L0) with arbitrary neutrino mass. PMID- 9959852 TI - Evidence of the 17-keV neutrino in the beta spectrum of 35S. PMID- 9959853 TI - Evidence of the 17-keV neutrino in the beta spectrum of 3H. PMID- 9959854 TI - Search for free quarks produced at 800 GeV/c using a new concentration technique. PMID- 9959855 TI - Measurement of single and double radiative low-Q2 Bhabha scattering at Ec.m. PMID- 9959856 TI - Diffractive production of pi - pi - pi + in 200-GeV/c pi -N interactions. PMID- 9959858 TI - String-breaking model for phi phi production. PMID- 9959857 TI - T-odd and CP-odd aplanarities in e+e- colliders. PMID- 9959859 TI - Production of heavy spin-(3/2 fermions in colliders. PMID- 9959860 TI - Dynamic Debye screening for a heavy-quark-antiquark pair traversing a quark-gluon plasma. PMID- 9959861 TI - Flavor-changing decays of the Z into heavy neutrinos. PMID- 9959863 TI - B-B-bar mixing and two-scalar-doublet model predicting a Fritzsch structure. PMID- 9959862 TI - Roper resonances and generator coordinate method in the chiral-soliton model. PMID- 9959865 TI - Light neutrino masses in the Fritzsch model with horizontal Peccei-Quinn symmetry. PMID- 9959864 TI - Radiative quark and lepton masses through soft supersymmetry breaking. PMID- 9959867 TI - Kinetic-theory approach to quark-gluon plasma oscillations. PMID- 9959866 TI - Nonadiabatic neutrino oscillations in matter. PMID- 9959868 TI - Spectrum of QCD and chiral Lagrangians of the strong and weak interactions. PMID- 9959869 TI - Realistic pseudoscalar-vector Lagrangian. Static and dynamical baryon properties. PMID- 9959870 TI - Renormalization of the flavor-changing neutral currents. PMID- 9959871 TI - Supersymmetric left-right E6 gauge model: Flavor-changing interactions. PMID- 9959872 TI - Natural and realistic subquark model with solvable dynamics. PMID- 9959873 TI - Spontaneous compactification effects, low-energy signature of quark-lepton unification, and small neutrino masses in SO(10). PMID- 9959874 TI - Symmetry breaking in three-generation Calabi-Yau manifolds. PMID- 9959875 TI - Cross section of monopole-induced Skyrmion decay. PMID- 9959876 TI - Phenomenology of small violations of Fermi and Bose statistics. PMID- 9959877 TI - Beam optics of a self-focusing plasma lens. PMID- 9959879 TI - Properties of nuclear production of J/ psi (3.097). PMID- 9959878 TI - Detecting the radiation amplitude zeros in pp-->X gamma and pp-bar-->X gamma. PMID- 9959881 TI - Proof of three-flavor scattering formulas. PMID- 9959880 TI - Internal meson dominance for pp-bar annihilation. PMID- 9959882 TI - 1(--)-->0(-+) meson radiative and pionic transitions and mass splittings. PMID- 9959883 TI - Radiative neutrino decays and scattering experiments. PMID- 9959884 TI - Vub/Vcb suppression from an asymmetric variation of the Fritzsch model. PMID- 9959886 TI - CP violation in supersymmetric models. PMID- 9959885 TI - Effective mass of quarks and radiative decays of vector mesons. PMID- 9959887 TI - Direct compatibility check of the Cambridge Electron Accelerator and Cornell pion form-factor data from e-N-->e- pi N with e+e---> pi + pi - PMID- 9959889 TI - Making inflation work: Damping of density perturbations due to Planck energy cutoff. PMID- 9959888 TI - Design for a practical laboratory detector for solar axions. PMID- 9959891 TI - Nonzero vacuum expectation values in higher-dimensional cosmology. PMID- 9959890 TI - Cosmological cosmic strings. PMID- 9959892 TI - Pseudoscalar versus pseudovector pion-nucleon couplings in the nucleonic axion bremsstrahlung rate of neutron-star matter. PMID- 9959893 TI - Renormalized stress-energy tensor near the horizon of a slowly evolving, rotating black hole. PMID- 9959894 TI - Nonlinear solutions for initial data in the vacuum Einstein equations in plane symmetry. PMID- 9959896 TI - Rindler observers, correlated states, boundary conditions, and the meaning of the thermal spectrum. PMID- 9959895 TI - Colliding superposed waves in the Einstein-Maxwell theory. PMID- 9959898 TI - Conformal rotation in Bianchi type-I quantum cosmology. PMID- 9959897 TI - Mixmaster cosmological model in theories of gravity with a quadratic Lagrangian. PMID- 9959899 TI - Wave function of the Universe as a leaking system. PMID- 9959900 TI - Steepest-descent contours in the path-integral approach to quantum cosmology. I. The de Sitter minisuperspace model. PMID- 9959902 TI - Universe creation from the third-quantized vacuum. PMID- 9959901 TI - Probabilistic time in quantum gravity. PMID- 9959903 TI - Gaussian and 1/N approximations in semiclassical cosmology. PMID- 9959904 TI - Stochastic inflation as a time-dependent random walk. PMID- 9959905 TI - Nonequilibrium statistical quantum field theory for open systems. PMID- 9959906 TI - Arnowitt-Deser-Misner energy and three-momentum for a simplicial space. PMID- 9959907 TI - Dirac constraint quantization of a parametrized field theory by anomaly-free operator representations of spacetime diffeomorphisms. PMID- 9959909 TI - Thermal equilibrium in de Sitter space. PMID- 9959908 TI - High-energy equivalence theorem in spontaneously broken supergravity. PMID- 9959910 TI - Does there exist a sensible quantum theory of an "algebra-valued" scalar field? PMID- 9959911 TI - Fine structure of local and axion strings. PMID- 9959912 TI - Approach to general covariance in string space of BRST string field theory. PMID- 9959913 TI - Vanishing vacuum amplitude of four-dimensional heterotic string theory compactified on N=2 superconformal field theory. PMID- 9959914 TI - Adiabatic holonomy and evolution of fermionic coherent state. PMID- 9959916 TI - Nonunique solution to the Schwinger-Dyson equations. PMID- 9959915 TI - Covariant Gaussian approximation. I. Formalism. PMID- 9959917 TI - Fractional spin in the gauged O(3) sigma model. PMID- 9959919 TI - Symmetry breaking by Wilson loops. Finite-temperature effects. PMID- 9959918 TI - Green's functions of composite operators and bound states in gauge theories. PMID- 9959920 TI - Triviality, anomalies, and canonical electroweak theory at small distances. PMID- 9959921 TI - Periodic and quasiperiodic SU(N) instantons. PMID- 9959923 TI - Nonrenormalization of the Wess-Zumino-Witten term in the two-dimensional nonlinear sigma model. PMID- 9959922 TI - The supercurrent and spontaneously broken supersymmetry. PMID- 9959924 TI - Uniqueness of quarks, leptons, and exotic fermions in the chiral-color models. PMID- 9959925 TI - Eighth-order magnetic moment of the electron. IV. Vertex diagrams containing photon-photon scattering subdiagrams. PMID- 9959926 TI - Magnetic effects and chiral-symmetry breaking in strongly coupled quantum electrodynamics. PMID- 9959927 TI - Gluon poles from Feynman graphs, and gauge-invariant amplitudes. PMID- 9959928 TI - Quantum chaos in the mixmaster universe. PMID- 9959929 TI - Critical line and dilaton in scale-invariant QED. PMID- 9959930 TI - Gaussian effective potential on the Hamiltonian lattice. PMID- 9959932 TI - Erratum: Functional derivatives, Green's functions, and effective potentials on the Hamiltonian lattice PMID- 9959931 TI - Time in semiclassical gravity. PMID- 9959933 TI - On the Mashhoon-Theiss "anomaly" PMID- 9959935 TI - Possibility of a sudden flip or disappearance of electromagnetic fields without photon emission. PMID- 9959934 TI - Wormhole effect on the superstring axion. PMID- 9959936 TI - Recoil-proton polarization in pi p elastic scattering at 547 and 625 MeV/c. PMID- 9959937 TI - Charge-symmetry breaking in np elastic scattering at 477 MeV. PMID- 9959938 TI - Multiparticle production by 200-GeV/c hadrons on gold, silver, and magnesium targets. PMID- 9959940 TI - Search for supermassive Cahn-Glashow particles in lead. PMID- 9959939 TI - Inclusive charged-D production in 205-GeV/c pi - Be interactions. PMID- 9959941 TI - Extra neutral gauge boson and the processes e+e--->ZiHa in a superstring-inspired model. PMID- 9959942 TI - Searching for an exotic lepton and gauge boson at high-energy e+e- colliders. PMID- 9959944 TI - Radiative zeros and extra neutral gauge bosons at lepton-hadron colliders. PMID- 9959943 TI - Three-jet process in virtual photon-photon annihilation. PMID- 9959945 TI - Production of supersymmetric particles in elastic ep collisions. PMID- 9959946 TI - Isoscalar axial-vector renormalization constant and polarized proton structure function. PMID- 9959947 TI - Tests for determining the parton ancestor of a hadron jet. PMID- 9959948 TI - Multiplicity distributions in high-energy hadron-nucleus collisions. I. Formalism. PMID- 9959949 TI - Multiplicity distributions in high-energy hadron-nucleus collisions. II. Phenomenology. PMID- 9959951 TI - Multiple-collision model for high-energy nucleus-nucleus collisions. PMID- 9959950 TI - Scattering in nuclei and QCD. PMID- 9959952 TI - Tests of three-vector-boson nonstandard couplings. PMID- 9959953 TI - How to elucidate the mechanism of CP violation. PMID- 9959954 TI - KL--> pi 0l+l- decays for large mt. PMID- 9959956 TI - Two- gamma decay widths of glueballs. PMID- 9959955 TI - Photon polarization in charged-pion radiative decay. PMID- 9959958 TI - Hadron spectrum of quenched QCD and the quark model. PMID- 9959957 TI - Superheavy-quarkonium decays with two Higgs doublets. PMID- 9959959 TI - Vector-meson decay into pseudoscalar mesons from quenched lattice QCD. PMID- 9959960 TI - Renormalization of Higgs-boson-mass sum rules and screening. PMID- 9959961 TI - Hyperchargeless triplet Majoron model. PMID- 9959962 TI - Studies of confinement: How the gluon propagates. PMID- 9959963 TI - Hadron scattering in the large-Nc limit as a problem in linear algebra. PMID- 9959965 TI - Screening of heavy-Higgs-boson radiative effects. PMID- 9959964 TI - String potential model: Spinless quarks. PMID- 9959966 TI - On-shell gauge-parameter independence of contributions to electroweak quark self-energies. PMID- 9959968 TI - Longitudinal impedance of a periodic structure at high frequency. PMID- 9959967 TI - High-frequency behavior of the longitudinal impedance for a cavity of general shape. PMID- 9959970 TI - Analysis of two-body decays of charm mesons using the quark-diagram scheme: Addendum on hairpin diagrams. PMID- 9959969 TI - Search for a light Higgs boson in rare K decays. PMID- 9959972 TI - Interaction of massive neutrinos with electrons. PMID- 9959971 TI - Fourth-generation effect on anticharm-charm asymmetry in B0 inclusive decays. PMID- 9959973 TI - g-2 of the muon from compositeness in the model of Abbott and Farhi. PMID- 9959974 TI - Complete cancellation of anomalous quadrupole moment of W in supersymmetric SU(2)L x U(1)Y. PMID- 9959975 TI - Linear sigma model with parity doubling. PMID- 9959977 TI - New metastable states in supercritical QED. PMID- 9959976 TI - WW signatures from top quarks at the Fermilab Tevatron. PMID- 9959978 TI - Morphology of amorphous layers ballistically deposited on a planar substrate. PMID- 9959980 TI - Multifractality of flow distribution in the river-network model of Scheidegger. PMID- 9959979 TI - Extensive numerical study of spectral statistics for rational and irrational polygonal billiards. PMID- 9959981 TI - Stochastic models of exciton transport: The Haken-Strobl model. PMID- 9959982 TI - Signature of classical chaos on quantum tunneling. PMID- 9959984 TI - Self-organizing systems at finite driving rates. PMID- 9959983 TI - Controlling Hamiltonian chaos. PMID- 9959986 TI - Real-time path-integral approach to quantum coherence and dephasing in nonadiabatic transitions and nonlinear optical response. PMID- 9959985 TI - Verhulst-type kinetics driven by white shot noise: Exact solution by direct averaging. PMID- 9959987 TI - Langevin dynamics, scale invariance, and granular flows. PMID- 9959988 TI - Spatially periodic orbits in coupled-map lattices. PMID- 9959989 TI - Sensitivity to initial conditions in stochastic systems. PMID- 9959991 TI - Nonequilibrium variational principle for the time evolution of an ionized gas. PMID- 9959990 TI - Dynamical behavior of a thermostated isotropic harmonic oscillator. PMID- 9959992 TI - Transient phenomena, self-diffusion, and orientational effects in vibrated powders. PMID- 9959993 TI - Mean first-passage times for systems driven by gamma and McFadden dichotomous noise. PMID- 9959994 TI - Simple models of non-Gaussian statistics for a turbulently advected passive scalar. PMID- 9959996 TI - Topological defects, correlation functions, and power-law tails in phase-ordering kinetics. PMID- 9959995 TI - Splay states in globally coupled Josephson arrays: Analytical prediction of Floquet multipliers. PMID- 9959998 TI - Dynamic-light-scattering study of glasses of hard colloidal spheres. PMID- 9959997 TI - Chaotic proton dynamics in the hydrogen bond. PMID- 9960000 TI - Control of NMR-laser chaos in high-dimensional embedding space. PMID- 9959999 TI - Exact enumeration of self-avoiding walks on lattices with random site energies. PMID- 9960001 TI - Dynamical correlations and the direct summation method of evaluating infinite continued fractions. PMID- 9960002 TI - Long-time semiclassical dynamics of chaos: The stadium billiard. PMID- 9960003 TI - Master Langevin equations: Origin of asymptotic diffusion. PMID- 9960005 TI - Fluctuation-diffusion relationship in chaotic dynamics. PMID- 9960004 TI - Higher-dimensional targeting. PMID- 9960006 TI - Comparison of random configurations of equal disks. PMID- 9960007 TI - Stochastic model for a wavelike exothermal reaction in condensed heterogeneous systems. PMID- 9960008 TI - Spherical-harmonics decomposition of the Boltzmann equation for charged-particle swarms in the presence of both electric and magnetic fields. PMID- 9960010 TI - Weakly nonlocal hydrodynamics. PMID- 9960009 TI - Molecular dynamics at constant temperature and pressure. PMID- 9960011 TI - Mechanism of energy transformations in shear magnetohydrodynamic flows. PMID- 9960012 TI - Effect of viscosity on Rayleigh-Taylor and Richtmyer-Meshkov instabilities. PMID- 9960013 TI - Bimodality and transient trimodality for Brownian particles in shear flows: A path-integral approach. PMID- 9960014 TI - Global thermodynamic behavior of fluid mixtures in the critical region. PMID- 9960015 TI - Shock fluctuations in one-dimensional lattice fluids. PMID- 9960017 TI - Calculation of the ground-state energy V0 of quasifree positrons in rare-gas fluids. PMID- 9960016 TI - Scattering function for a model of interacting surfaces. PMID- 9960018 TI - Electric-field-induced phase transition in electrorheological fluids. PMID- 9960019 TI - Model for density-functional thermodynamic perturbation analysis of Lennard-Jones solids. PMID- 9960020 TI - Light-scattering technique for the study of dynamic thickness fluctuations in thin liquid films. PMID- 9960021 TI - Quantitative lattice measurement of thin Langmuir-Blodgett films by atomic-force microscopy. PMID- 9960022 TI - Shape equations of the axisymmetric vesicles. PMID- 9960023 TI - Dynamic percolation of spheres in a continuum: The case of microemulsions. PMID- 9960025 TI - Hard-sphere and hard-disk freezing from the differential formulation of the generalized effective liquid approximation. PMID- 9960024 TI - Activated dynamics, loss of ergodicity, and transport in supercooled liquids. PMID- 9960027 TI - Orientational order in simple dipolar fluids: Density-functional theory and absolute-stability conditions. PMID- 9960026 TI - Monte Carlo simulation study of mesophase formation in dipolar spherocylinders. PMID- 9960028 TI - Interface dynamics and banding in rapid solidification. PMID- 9960030 TI - Negative-energy waves in an inhomogeneous force-free Vlasov plasma with sheared magnetic field. PMID- 9960029 TI - Testing singularities in the complex plane: Suggestions for dendritic-growth experiments. PMID- 9960032 TI - Ion-ion interaction and equation of state of a dense plasma: Application to beryllium. PMID- 9960031 TI - Experiments on grid-excited solitons in a positive-ion-negative-ion plasma. PMID- 9960033 TI - Electron-temperature inhomogeneities along an x-ray laser plasma. PMID- 9960034 TI - Resistive model of the rf discharge including additional dc currents and electrodes. PMID- 9960035 TI - Collective modes in nonrelativistic electron-positron plasmas. PMID- 9960036 TI - Self-consistent model for the nonequilibrium cathode region. PMID- 9960037 TI - State-specific mobility of excited cadmium and calcium ions in a discharge plasma measured by a tunable diode laser. PMID- 9960038 TI - Impact ionization in nonideal plasmas in a strong electric field. PMID- 9960039 TI - Characteristics of synchrotron C-caronerenkov radiation. PMID- 9960040 TI - Coupling impedance of beam pipes of general cross section. PMID- 9960041 TI - Contributions to the electromagnetic wave theory of bounded homogeneous anisotropic media. PMID- 9960042 TI - Transverse stability of Kawahara solitons. PMID- 9960043 TI - Brillouin-scattering study of hyaluronic acid: Dynamic coupling with the water of hydration and phase transitions. PMID- 9960044 TI - Dynamics and thermodynamics of a nonlinear model for DNA denaturation. PMID- 9960045 TI - Application of finite-size scaling to the Pink model for lipid bilayers. PMID- 9960046 TI - Detecting structure in two dimensions combining Voronoi tessellation and percolation. PMID- 9960047 TI - Universality classes of second-order dynamical phase transitions. PMID- 9960048 TI - Method of controlling chaos in laser equations. PMID- 9960049 TI - Density-functional method for lattice-gas problems. PMID- 9960050 TI - Large-scale chaos in the neutral-line Hamiltonian. PMID- 9960051 TI - Himalayan sandpiles. PMID- 9960052 TI - Bogoliubov-Born-Green-Kirkwood-Yvon hierarchy for higher forms. PMID- 9960053 TI - Sandpiles and diffusion-limited reactions. PMID- 9960054 TI - Scaling behavior of a directed sandpile automata with random defects. PMID- 9960056 TI - Quantum wave turbulence. PMID- 9960055 TI - Hausdorff dimension from the minimal spanning tree. PMID- 9960057 TI - A low-wave-vector expansion for reflectivity. PMID- 9960058 TI - Selection of toroidal shape of partially polymerized membranes. PMID- 9960059 TI - Alfven vortices in nonuniform dusty magnetoplasmas. PMID- 9960060 TI - Explosive instabilities of reaction-diffusion equations including pinch effects. PMID- 9960061 TI - Temperature dependence of Stark broadening for several Si II lines. PMID- 9960063 TI - Gauge-invariance aspects of the canonical perturbation theory. PMID- 9960062 TI - Stress distribution of a hexagonally packed granular pile. PMID- 9960064 TI - Critical behavior of branching annihilating random walks with an odd number of offsprings. PMID- 9960065 TI - Singularity spectrum of self-organized criticality. PMID- 9960067 TI - Nonstable solitons and sharp criteria for wave collapse. PMID- 9960066 TI - Universal amplitudes of power-law tails in the asymptotic structure factor of systems with topological defects. PMID- 9960069 TI - Numerical test of finite-barrier corrections for the hopping rate in a periodic potential. PMID- 9960068 TI - Scaling properties of the shadowing model for sputter deposition. PMID- 9960070 TI - Modeling shock waves in an ideal gas: Going beyond the Navier-Stokes level. PMID- 9960072 TI - Adsorption of polymers on a random surface. PMID- 9960071 TI - From small scales to large scales in three-dimensional turbulence: The effect of diluted polymers. PMID- 9960073 TI - Spinodal decomposition in a three-dimensional fluid model. PMID- 9960074 TI - Properties of the reaction front in a reversible A+B PMID- 9960075 TI - Entropy-driven DNA denaturation. PMID- 9960077 TI - Selection mechanism and area distribution in two-dimensional cellular structures. PMID- 9960076 TI - Dispersion relation around the kink solution of the Cahn-Hilliard equation. PMID- 9960079 TI - Geometrical hints for a nonperturbative approach to Hamiltonian dynamics. PMID- 9960078 TI - Spatiotemporal dynamics due to stick-slip friction in an elastic-membrane system. PMID- 9960080 TI - Scale-invariant motion in intermittent chaotic systems. PMID- 9960081 TI - Coupling among three chemical oscillators: Synchronization, phase death, and frustration. PMID- 9960082 TI - Multifractal formalism for fractal signals: The structure-function approach versus the wavelet-transform modulus-maxima method. PMID- 9960083 TI - Reaction-diffusion lattice gas: Theory and computer results. PMID- 9960084 TI - Water erosion as a fractal growth process. PMID- 9960085 TI - Long-wavelength properties of the Kuramoto-Sivashinsky equation. PMID- 9960086 TI - Analytic calculation of the diffusion coefficient for random walks on strips of finite width: Dependence on size and nature of boundaries. PMID- 9960087 TI - Activated rate processes: Finite-barrier expansion for the rate in the spatial diffusion limit. PMID- 9960088 TI - Asymmetric free energy from Riemannian geometry. PMID- 9960089 TI - Kosterlitz-Thouless transition in a dilute Bose gas. PMID- 9960090 TI - Ziff-Gulari-Barshad model with CO desorption: An Ising-like nonequilibrium critical point. PMID- 9960091 TI - Multifractality of probability measure on energy-spectrum supports. PMID- 9960093 TI - Dynamic autoresonance and global chaos in a slowly evolving system of two coupled oscillators. PMID- 9960092 TI - Gradients of potential fields on rough surfaces: Perturbative calculation of the singularity distribution function f( alpha ) for small surface dimension. PMID- 9960094 TI - Small-noise approximations to the solution of the Smoluchowski equation. PMID- 9960096 TI - Quantum Poincare sections for two-dimensional billiards. PMID- 9960095 TI - Ferromagnetic phase transition in random Potts spin chains. PMID- 9960097 TI - Fractal renewal processes generate 1/f noise. PMID- 9960098 TI - Stability exchanges between periodic orbits in a Hamiltonian dynamical system. PMID- 9960100 TI - Differential condition of thermodynamic consistency as a closure for the Ornstein Zernike equation. PMID- 9960099 TI - Shadowing instability in three dimensions. PMID- 9960101 TI - Kinetics of the monomer-monomer surface reaction model. PMID- 9960102 TI - Light-scattering measurements of nonequilibrium fluctuations in a liquid mixture. PMID- 9960103 TI - Numerical inverse-scattering-transform analysis of laboratory-generated surface wave trains. PMID- 9960104 TI - Repeated transients of weakly nonlinear traveling-wave convection. PMID- 9960105 TI - Thermodynamics of Taylor dispersion: Constitutive equations. PMID- 9960107 TI - Phonon-particle interactions and transport processes in liquids. PMID- 9960106 TI - Characterization of period-doubling scenarios in Taylor-Couette flow. PMID- 9960108 TI - Long-wavelength analysis of the coupling between solidification and Soret-driven convection at positive separation ratio. PMID- 9960109 TI - Asymptotic behavior of viscous-fingering patterns in circular geometry. PMID- 9960110 TI - Magnetic-field-induced biaxiality in an antiferroelectric liquid crystal. PMID- 9960111 TI - Novel dynamical mode in a tilted smectic liquid-crystal film. PMID- 9960112 TI - Glass transition and dynamic-mobility spectrum of an isotropic system of rodlike molecules. PMID- 9960113 TI - Absence of the nematic phase in symmetric diblock copolymers. PMID- 9960115 TI - Kinetics of spinodal decomposition in a polymer mixture. PMID- 9960114 TI - Hydrothermal waves in Marangoni convection in a cylindrical container. PMID- 9960117 TI - Growth instability and pricking-fracture mechanism in smectic-A focal-conic nucleation. PMID- 9960116 TI - Ion-director coupling in a ferroelectric liquid crystal. PMID- 9960118 TI - Crystal growth in a channel: Numerical study of the one-sided model. PMID- 9960119 TI - Theory of phase-separation dynamics in quenched binary mixtures. PMID- 9960120 TI - Phase separation and curvature of bilayer membranes. PMID- 9960121 TI - Critical points in layered systems. PMID- 9960122 TI - Growth of a single drop formed by diffusion and adsorption of monomers on a two dimensional substrate. PMID- 9960123 TI - High-resolution calorimetric study of the antiferroelectric liquid crystals methylheptyloxycarbonylphenyl octyloxybiphenyl carboxylate and its octylcarbonylbiphenyl analog. PMID- 9960124 TI - Planar density-functional approach to the solid-fluid interface of simple liquids. PMID- 9960125 TI - Interplay of orientational order and viscoelasticity in supercooled liquids near the glass transition. PMID- 9960126 TI - Planar solidification from an undercooled melt: Asymptotic solutions to a continuum model with interfacial kinetics. PMID- 9960127 TI - Monte Carlo simulation studies of dendritic instabilities in three dimensions. PMID- 9960128 TI - Biharmonic pattern selection. PMID- 9960129 TI - Interaction of a weakly nonlinear laser pulse with a plasma. PMID- 9960130 TI - Time-dependent electron kinetics in N2 and H2 for a wide range of the field frequency including electron-vibration superelastic collisions. PMID- 9960131 TI - Stopping power of extended cluster and ion charge distributions in an arbitrarily degenerate electron fluid. PMID- 9960132 TI - Partition functions of rare-earth halide plasmas. PMID- 9960133 TI - Fast-discharge excitation of hot capillary plasmas for soft-x-ray amplifiers. PMID- 9960134 TI - Characterization of a capillary-discharge plasma. PMID- 9960135 TI - Generation of coherent undulator radiation using a relativistic photoelectron beam with picosecond micropulses. PMID- 9960136 TI - Microsphere-based short-wavelength recombination x-ray laser. PMID- 9960137 TI - Transition operators in electromagnetic-wave diffraction theory. II. Applications to optics. PMID- 9960138 TI - Manifestly covariant formalism for electromagnetism in chiral media. PMID- 9960140 TI - Generalization ability of perceptrons with continuous outputs. PMID- 9960139 TI - Length-scale competition for the one-dimensional nonlinear Schrodinger equation with spatially periodic potentials. PMID- 9960141 TI - Class of Hamiltonian neural networks. PMID- 9960142 TI - Basin of attraction in networks of multistate neurons. PMID- 9960143 TI - Persistent self-organization of sandpiles. PMID- 9960144 TI - Experimental observation of type-II intermittency in a hydrodynamic system. PMID- 9960145 TI - Generating strange nonchaotic trajectories. PMID- 9960147 TI - Velocity selection in coupled-map lattices. PMID- 9960146 TI - Canonically modified Nose-Hoover equation with explicit inclusion of the virial. PMID- 9960148 TI - Pattern selection at high nonlinearity in a diffusively coupled logistic lattice. PMID- 9960149 TI - Soliton on a disordered lattice. PMID- 9960150 TI - Long-time limit of the self-correlation-function of one-dimensional diffusion. PMID- 9960151 TI - Late-stage phase separation and sedimentation in a binary liquid mixture. PMID- 9960152 TI - Rotating-liquid-drop model limit tested on macroscopic drops. PMID- 9960153 TI - Effect of long-range forces on surface enrichment in polymer blends. PMID- 9960154 TI - Critical exponents for a self-interacting, directed polymer with adsorption. PMID- 9960155 TI - Experimental studies on the temperature behavior of the nonlinear dielectric effect in a critical binary solution. PMID- 9960156 TI - Size dependence of the minimum-growth probabilities of typical diffusion-limited aggregation clusters. PMID- 9960158 TI - Strange attractor of the modulated Stokes wave: A universal form. PMID- 9960157 TI - Nonuniversal diffusion in a chain with deterministic local drifts. PMID- 9960160 TI - Controlling chaos in highly dissipative systems: A simple recursive algorithm. PMID- 9960159 TI - Law of proliferation of periodic orbits in pseudointegrable billiards. PMID- 9960161 TI - Discerning differences among anomalously wandering directed polymers. PMID- 9960162 TI - Parametrically excited quasicrystalline surface waves. PMID- 9960163 TI - Lamellar phase in a model for block copolymers. PMID- 9960164 TI - Blow-up in the Boussinesq equation. PMID- 9960165 TI - Interaction between a drifting spiral and defects. PMID- 9960167 TI - Nonadiabatic response theory: The case of volume change. PMID- 9960166 TI - Critical finite-range scaling in scalar-field theories and Ising models. PMID- 9960168 TI - Ordering kinetics in systems with long-range interactions. PMID- 9960169 TI - Light-controlled anchoring of meandering spiral waves. PMID- 9960170 TI - Standard fluctuation-dissipation process from a deterministic mapping. PMID- 9960171 TI - Long-range interactions generated by random Levy flights: Spin-flip and spin exchange kinetic Ising model in two dimensions. PMID- 9960172 TI - Coarsening dynamics of the XY model. PMID- 9960173 TI - Thermal cycle around the critical point of carbon dioxide under reduced gravity. PMID- 9960174 TI - Normal solutions for master equations with time-dependent transition rates: Application to heating processes. PMID- 9960175 TI - Geometrical and dynamical properties of homoclinic tangles in a simple Hamiltonian system. PMID- 9960177 TI - Driven diffusive system with quenched impurities. PMID- 9960176 TI - Nonlinear-relaxation-time and quasideterministic-theory approaches to characterize the decay of unstable states. PMID- 9960178 TI - Mode-coupling theory and simulation results for the "running-sandpile" model of self-organized criticality. PMID- 9960180 TI - Adiabatic approach to mean-first-passage-time computation in bistable potential with colored noise. PMID- 9960179 TI - Resummation of classical and semiclassical periodic-orbit formulas. PMID- 9960181 TI - Deterministic and stochastic surface growth with generalized nonlinearity. PMID- 9960182 TI - Roughening of chemically reacting interfaces. PMID- 9960183 TI - Directed random walk with spatially correlated random transfer rates. PMID- 9960184 TI - Evolutionary dynamics of a multigroup fluctuating-population system. PMID- 9960185 TI - Spatiotemporal dynamics of an intrinsically chaotic field. PMID- 9960187 TI - Bistability driven by white shot noise. PMID- 9960186 TI - Giant nonlinearity in the low-frequency response of a fluctuating bistable system. PMID- 9960188 TI - Beyond the n=0 limit restriction for random-surface theories as derived from Hamiltonian gauge models. PMID- 9960189 TI - Weak localization in a chaotic periodically driven anharmonic oscillator. PMID- 9960190 TI - Parametric motion of energy levels in quantum chaotic systems. I. Curvature distributions. PMID- 9960191 TI - Parametric motion of energy levels in quantum chaotic systems. II. Avoided crossing distributions. PMID- 9960192 TI - Fast sound in liquid water. PMID- 9960193 TI - Shear viscosity and normal pressure differences in the scope of the extended Kirkwood-Smoluchowski equation. PMID- 9960194 TI - Mode-coupling analysis of atomic dynamics in liquid lead. PMID- 9960195 TI - Relationship between McQuarrie and Helfand equations for the determination of shear viscosity from equilibrium molecular dynamics. PMID- 9960196 TI - Triplet correlation functions for hard spheres: Comparison of different approaches. PMID- 9960197 TI - Successive bifurcations in directional viscous fingering. PMID- 9960198 TI - Convection in binary fluids: Amplitude equations, codimension-2 bifurcation, and thermal fluctuations. PMID- 9960199 TI - Canonical formalism, fundamental equation, and generalized thermomechanics for irreversible fluids with heat transfer. PMID- 9960200 TI - Self-diffusion of rodlike molecules in strong shear fields. PMID- 9960201 TI - Exact relations in the theory of developed hydrodynamic turbulence. PMID- 9960202 TI - Burgers's turbulence model as a stochastic dynamical system: Master equation and simulation. PMID- 9960203 TI - Lattice Boltzmann model for simulating flows with multiple phases and components. PMID- 9960204 TI - Spreading of a solid-on-solid drop. PMID- 9960205 TI - Supercooling of a nematic liquid crystal. PMID- 9960206 TI - Structure of the effective Hamiltonian for liquid-vapor interfaces. PMID- 9960207 TI - Critical behavior of a three-component microemulsion. PMID- 9960209 TI - Optical activity in the smectic-A phase of a highly chiral liquid crystal. PMID- 9960208 TI - Bulk and interfacial wetting properties of binary liquid mixtures. PMID- 9960210 TI - Surfacelike-elasticity-induced spontaneous twist deformations and long-wavelength stripe domains in a hybrid nematic layer. PMID- 9960211 TI - Phase-field model of solute trapping during solidification. PMID- 9960212 TI - Critical behavior at nematic-smectic-A1 phase transitions. I. High-resolution x ray-scattering and calorimetric study of the liquid-crystal octyloxyphenylnitrobenzoyloxy benzoate. PMID- 9960213 TI - Critical behavior at nematic-smectic-A1 phase transtions. II. Preasymptotic three dimensional XY analysis of x-ray and Cp data. PMID- 9960214 TI - Modal behavior observed in the evolution of immiscible interfaces within an injection-forced Hele-Shaw cell. PMID- 9960215 TI - Energy of linear quasineutral electrostatic drift waves. PMID- 9960216 TI - Continuous-electron-beam focusing induced by collective plasma interactions in D2 and H2. PMID- 9960217 TI - Plasma conditions for non-Maxwellian electron distributions in high current discharges and laser-produced plasmas. PMID- 9960218 TI - Nonlinear mode conversion with chaotic soliton generation at plasma resonance. PMID- 9960219 TI - Determination of gas-temperature and velocity profiles in an argon thermal-plasma jet by laser-light scattering. PMID- 9960220 TI - Measurements of Stark broadening of some long-wavelength transitions in C V, C VI, and N V. PMID- 9960222 TI - Theory of longitudinal Schottky spectra of ordered ion beams in a storage ring. PMID- 9960221 TI - Dynamic aperture of electron storage rings with noninterleaved sextupoles. PMID- 9960224 TI - Energy conservation of a uniformly accelerated point charge. PMID- 9960223 TI - Ponderomotive focusing in axisymmetric rf linacs. PMID- 9960225 TI - Dynamic behavior of an electron ring close to a cyclotron resonance in a modified betatron accelerator. PMID- 9960227 TI - Photonic bands in simple and body-centered-cubic cholesteric blue phases. PMID- 9960226 TI - Analytic and numerical study of two-frequency undulator radiation. PMID- 9960228 TI - Radiation by solitons due to higher-order dispersion. PMID- 9960230 TI - Theory of pressure-dependent melting of the DNA double helix: Role of strained hydrogen bonds. PMID- 9960229 TI - RNA folding and combinatory landscapes. PMID- 9960232 TI - Photoemission spectromicroscopy of neurons. PMID- 9960231 TI - Lateral diffusion coefficients of phospholipids in spherical bilayers on a solid support measured by 2H-nuclear-magnetic-resonance relaxation. PMID- 9960233 TI - Bose condensation for the Wu-Austin Hamiltonian without pumping. PMID- 9960234 TI - Simulation of the differential adhesion driven rearrangement of biological cells. PMID- 9960235 TI - Distributed dynamics in neural networks. PMID- 9960237 TI - Transition to a turbulent spectrum in the presence of viscous damping. PMID- 9960236 TI - Generalization transitions in hidden-layer neural networks for third-order feature discrimination. PMID- 9960239 TI - Fluctuation relation for the temperature derivative of Lyapunov exponents. PMID- 9960238 TI - Signatures of chaos in the modulus and phase of time-dependent wave functions. PMID- 9960241 TI - Exact solution for a two-stage stochastic evolution system. PMID- 9960240 TI - Levy walks and propagators in intermittent chaotic systems. PMID- 9960242 TI - Scaling relations for forced oscillators in the transition from a dissipative to a Hamiltonian system. PMID- 9960243 TI - Equation of state for "classical" helium. PMID- 9960244 TI - Exact statistical model accounting for surface fluctuations in two-dimensional droplets. PMID- 9960246 TI - Implications of Griffith's condition on crack growth. PMID- 9960245 TI - "In-plane" orientational fluctuations in smectic-A liquid crystals. PMID- 9960247 TI - Influence of temperature on parametric x-ray intensity. PMID- 9960248 TI - Erratum: Statistical analysis of compressible turbulent shear flows with special emphasis on turbulence modeling PMID- 9960249 TI - Erratum: Relaxation induced by colored noise: Analytical results for multilevel systems PMID- 9960250 TI - Self-consistent approach to the Kardar-Parisi-Zhang equation. PMID- 9960251 TI - Dynamic equilibrium in granular flow obtained by a nonlinear dynamic equation. PMID- 9960252 TI - Random walks on random systems: Eigenspectrum of large Markov matrices. PMID- 9960253 TI - Space-resolved x-ray emission from the densest part of laser plasmas: Molecular satellite features and asymmetrical wings. PMID- 9960254 TI - Modulated instability in collisional plasmas. PMID- 9960256 TI - Filtered noise can mimic low-dimensional chaotic attractors. PMID- 9960255 TI - Consistent scaling of multifractal measures: Multifractal spatial correlations. PMID- 9960257 TI - Probe for morphology and hierarchical correlations in scale-invariant structures. PMID- 9960258 TI - Diffusion in a random medium: A Monte Carlo study. PMID- 9960259 TI - Application of reconstructed phase-space techniques for correlation-dimension calculations in a spatially extended dynamical system. PMID- 9960261 TI - Nonlinear-response effects in stochastic resonance. PMID- 9960260 TI - Axial next-nearest-neighbor Ising-model roughening transitions. PMID- 9960262 TI - Pile density is a control parameter of sand avalanches. PMID- 9960263 TI - Range of multifractality for random walks on random fractals. PMID- 9960264 TI - Stochastic averaging of the time-evolution operator for quantum systems driven by Ornstein-Uhlenbeck colored noise: A nonperturbative cluster cumulant method. PMID- 9960265 TI - Synchronization of chaotic trajectories using control. PMID- 9960266 TI - Relaxation from an intrinsically unstable state to the metastable state in a colored-noise-driven system. PMID- 9960267 TI - On self-organized criticality in nonconserving systems. PMID- 9960268 TI - Brownian dynamics in a thin sheet with momentum decay. PMID- 9960269 TI - Relaxational dynamics after the quench of a conserved system with a continuous symmetry. PMID- 9960271 TI - Extremely simple nonlinear noise-reduction method. PMID- 9960270 TI - N-dimensional Abelian sandpile model with nearest-neighbor toppling. PMID- 9960272 TI - Statistics and scarring of eigenvectors of a shell model. PMID- 9960273 TI - Competitive and noncompetitive reversible binding processes. PMID- 9960274 TI - Self-avoiding walks on compact fractals: Exact and Monte Carlo renormalization group results. PMID- 9960275 TI - General behavior of the quenched averaged spectral density with a change in the ensemble probability distribution. PMID- 9960276 TI - Suppression of energy fluctuations in the classical counterpart of quantum models. PMID- 9960277 TI - Dissipative corrections to escape probabilities of thermal-nonequilibrium systems. PMID- 9960278 TI - Diffusion-limited exciton fusion reaction in one-dimensional tetramethylammonium manganese trichloride (TMMC). PMID- 9960279 TI - Phase diagram of the five-vertex model. PMID- 9960280 TI - Perturbational view of inherent structures in water. PMID- 9960281 TI - Consistent integral equations for two- and three-body-force models: Application to a model of silicon. PMID- 9960283 TI - Role of low-pass filtering in the process of attractor reconstruction from experimental chaotic time series. PMID- 9960282 TI - Reformulation of recursive-renormalization-group-based subgrid modeling of turbulence. PMID- 9960284 TI - Pattern selection in rotating convection with experimental boundary conditions. PMID- 9960285 TI - Micellar-shape anisometry near isotropic-liquid-crystal phase transitions. PMID- 9960286 TI - Cell dynamics simulation for the phase ordering of nematic liquid crystals. PMID- 9960288 TI - Zero-sound-like modes in simple liquid metals. PMID- 9960287 TI - Hydrodynamic effects in polydisperse charged colloidal suspensions at short times. PMID- 9960289 TI - Positronium in xenon: The path-integral approach. PMID- 9960290 TI - Cellular-automata calculation of frequency-dependent permeability of porous media. PMID- 9960291 TI - Reconstruction of the orientational pair-correlation function from neutron diffraction data: The case of liquid hydrogen iodide. PMID- 9960292 TI - Volume-fraction dependence of elastic moduli and transition temperatures for colloidal silica gels. PMID- 9960293 TI - Nonlinear fluctuation effects in dilute polymer solutions in periodic flow. PMID- 9960295 TI - Directional growth of a smectic-A-smectic-B interface lying along a forbidden orientation. PMID- 9960296 TI - Two-dimensional aggregation of polystyrene latex particles. PMID- 9960294 TI - Phase diagram of a frustrated smectic liquid-crystal system and the absence of the incommensurate smectic-Ai2 phase. PMID- 9960298 TI - Free-energy model for charged Yukawa mixtures: Asymptotic strong-coupling limit and a nonlinear mixing rule. PMID- 9960297 TI - Spectral evidence of connected structures in liquid water: Effective Raman density of vibrational states. PMID- 9960299 TI - Power-law scattering in fluids with a nonscalar order parameter. PMID- 9960300 TI - Crossover from scalar to vectorial percolation in silica gelation. PMID- 9960301 TI - Dynamics of Ostwald ripening in the presence of surfactants. PMID- 9960302 TI - Prediction of dendritic spacings in a directional-solidification experiment. PMID- 9960303 TI - Crossover from fractal to compact flow from simulations of two-phase flow with finite viscosity ratio in two-dimensional porous media. PMID- 9960304 TI - Growth in non-Laplacian fields. PMID- 9960305 TI - Pattern formation in screened electrostatic fields: Growth in a channel and in two dimensions. PMID- 9960306 TI - Theory of resonant and stimulated excitation of magnetic-moment fields in wave plasma interactions. PMID- 9960307 TI - Analysis of K alpha line emission from aluminum plasmas created by intense proton beams. PMID- 9960309 TI - Time-resolved backside optical probing of picosecond-laser-pulse-produced plasma in solid materials. PMID- 9960308 TI - Wake-field excitation in two- and three-component plasmas. PMID- 9960310 TI - Pulsation of harmonic and K alpha emission from laser-produced plasmas. PMID- 9960312 TI - Recombination of argon in an expanding plasma jet. PMID- 9960311 TI - Shift and width of the H alpha line of hydrogen in dense plasmas. PMID- 9960313 TI - Escape time of heliumlike alpha resonance-line photons emitted from optically thick plasmas. PMID- 9960314 TI - Oscillations of low-current electrical discharges between parallel-plane electrodes. I. dc discharges. PMID- 9960315 TI - Oscillations of low-current electrical discharges between parallel-plane electrodes. II. Pulsed discharges in H2. PMID- 9960317 TI - Nonlinear self-consistent theory for crossed-field devices. PMID- 9960316 TI - Oscillations of low-current electrical discharges between parallel-plane electrodes. III. Models. PMID- 9960319 TI - Electromagnetism in anisotropic chiral media. PMID- 9960318 TI - Quasiclassical approximation for the beamstrahlung process. PMID- 9960320 TI - Bound states of envelope solitons. PMID- 9960321 TI - Vector statistics of correlated Gaussian fields. PMID- 9960322 TI - Dynamical behavior of the firings in a coupled neuronal system. PMID- 9960323 TI - Spatiotemporal pattern processing in a compartmental-model neuron. PMID- 9960324 TI - Neural filters for jet analysis. PMID- 9960325 TI - Colloid aggregation with short-step diffusion: A more realistic model in the reaction limit. PMID- 9960326 TI - Recursive-Green's-function analysis of wave propagation in two-dimensional nonhomogeneous media. PMID- 9960327 TI - Absence of enhanced fluctuations as a first-order phase transition is approached: An exact transfer-matrix study. PMID- 9960328 TI - Heat-capacity anomalies from four-layer liquid-crystal films: Experimental results and simulation results. PMID- 9960329 TI - Stick-slip response in electrorheological fluids. PMID- 9960330 TI - Pattern formation caused by double quenches in binary polymer mixtures: Response of phase-separated structure to a second quench within a two-phase region. PMID- 9960331 TI - Chord-length distribution function for two-phase random media. PMID- 9960332 TI - Dynamical properties of a ferroelectric nematic liquid crystal. PMID- 9960333 TI - Short-time electric-field dynamics at a neutral point in strongly coupled plasmas. PMID- 9960334 TI - Learning from examples in feedforward Boolean networks. PMID- 9960335 TI - Comment on "Negative temperature of vortex motion" PMID- 9960336 TI - Reply to "Comment on 'Negative temperature of vortex motion' " PMID- 9960337 TI - Trace formulas for arithmetical systems. PMID- 9960338 TI - Dynamics of spring-block models: Tuning to criticality. PMID- 9960339 TI - Two-frequency control and suppression of tunneling in the driven double well. PMID- 9960340 TI - Two-dimensional avalanches as stochastic Markov processes. PMID- 9960341 TI - Staircase polygons, elliptic integrals, Heun functions, and lattice Green functions. PMID- 9960342 TI - Coupled phase instability of a cellular pattern. PMID- 9960343 TI - Multidimensional pattern formation has an infinite number of constants of motion. PMID- 9960345 TI - Lattice Boltzmann thermohydrodynamics. PMID- 9960344 TI - Traveling-wave wall states in rotating Rayleigh-Benard convection. PMID- 9960346 TI - Temperature and velocity profiles of turbulent convection in water. PMID- 9960347 TI - Ramp-induced wave-number selection for traveling waves. PMID- 9960348 TI - Structure factor for phase ordering in nematic liquid crystals. PMID- 9960350 TI - Reorientation dynamics of ferroelectric liquid-crystal molecules near the smectic A-smectic-C* transition. PMID- 9960349 TI - Molecular dynamics of phase separation in narrow channels. PMID- 9960352 TI - Laser-induced electron acceleration in a counterpropagating rf field. PMID- 9960351 TI - Branch-height distribution in diffusion-limited deposition. PMID- 9960353 TI - Probability distributions for second-order processes driven by Gaussian noise. PMID- 9960354 TI - Vibrations of strongly irregular or fractal resonators. PMID- 9960355 TI - Late-stage coarsening for off-critical quenches: Scaling functions and the growth law. PMID- 9960356 TI - Critical behavior of three interacting strings. PMID- 9960357 TI - Stochastic transient of a noise-perturbed Haken-Zwanzig model. PMID- 9960358 TI - Rupture propagation, dynamical front selection, and the role of small length scales in a model of an earthquake fault. PMID- 9960359 TI - Local false nearest neighbors and dynamical dimensions from observed chaotic data. PMID- 9960360 TI - Dynamical lattice-model simulation. PMID- 9960361 TI - Loop structure of percolation hulls. PMID- 9960362 TI - Properties of a logistic map with a sectional discontinuity. PMID- 9960364 TI - Noise and slow-fast dynamics in a three-wave resonance problem. PMID- 9960363 TI - Sandpiles, avalanches, and the statistical mechanics of nonequilibrium stationary states. PMID- 9960365 TI - Phase flow and statistical structure of Galton-board systems. PMID- 9960366 TI - Constant-temperature molecular dynamics with momentum conservation. PMID- 9960367 TI - Asymptotic behavior of dynamical correlations via perturbative analysis of infinite continued fractions. PMID- 9960368 TI - Probability distributions of local Lyapunov exponents for Hamiltonian systems. PMID- 9960369 TI - Model-independent method for reconstruction of scattering-length-density profiles using neutron or x-ray reflectivity data. PMID- 9960370 TI - Domain-growth scaling in systems with long-range interactions. PMID- 9960371 TI - Thermodynamics and multicorrelations of intermittent dynamics. PMID- 9960372 TI - Cooperative few-level fluctuations in coupled quantum systems. PMID- 9960373 TI - Growth and form of two-dimensional rotating aggregates. PMID- 9960374 TI - Upper critical dimension for aggregation processes. PMID- 9960376 TI - Groove instabilities in surface growth with diffusion. PMID- 9960375 TI - Theory of interaction and bound states of spiral waves in oscillatory media. PMID- 9960377 TI - Evidence of a nondiffusive transport in a monodisperse screened Coulomb system by a molecular-dynamics simulation. PMID- 9960378 TI - Transport properties of nonequilibrium gas mixtures. PMID- 9960379 TI - Equipartition and ergodicity in closed one-dimensional systems of hard spheres with different masses. PMID- 9960380 TI - Virial expansion for ionic mixtures: Point-counterion model. PMID- 9960381 TI - Relaxation dynamics in a lattice gas: A test of the mode-coupling theory of the ideal glass transition. PMID- 9960382 TI - Nonlinear diffusion process in a Benard system at the critical point for the onset of convection. PMID- 9960383 TI - Scaling in fluid turbulence: A geometric theory. PMID- 9960384 TI - Evolution of induced patterns in surface-tension-driven Benard convection. PMID- 9960386 TI - System-size effects at the isotropic-nematic transition from computer simulation. PMID- 9960385 TI - Rotating Rayleigh-Benard convection: Aspect-ratio dependence of the initial bifurcations. PMID- 9960388 TI - Kinetic growth of randomlike and ballisticlike deposition models. PMID- 9960387 TI - Coarsening dynamics in uniaxial nematic liquid crystals. PMID- 9960389 TI - Computer simulations of nonequilibrium structure formation in electrorheological fluids. PMID- 9960390 TI - Curvature defects in a lamellar phase revealed by nuclear-spin-relaxation anisotropy. PMID- 9960391 TI - Ordering of hard needles at a hard wall. PMID- 9960392 TI - Reentrant phase transition in charged colloidal suspensions: A Monte Carlo study. PMID- 9960393 TI - Quantitative determination of the percolation threshold in waterless microemulsions. PMID- 9960394 TI - Diffuse optical probes of particle motion and structure formation in an electrorheological fluid. PMID- 9960395 TI - Anisotropic critical properties of the hexatic N+6 phase near the transition to the hexagonal discotic phase. PMID- 9960396 TI - Dynamics of the lowest-order bend-twist director mode near nematic-smectic-A criticality. PMID- 9960397 TI - Effects of surface enhancement on fluctuation-induced interactions. PMID- 9960398 TI - Morphological instabilities of CBr4 crystals during growth from vapors. PMID- 9960399 TI - Generalization of the Poiseuille law for one- and two-phase flow in a random capillary network. PMID- 9960400 TI - Dynamics of phospholipid tubules in a concentrated solution: Results from high field magnetic birefringence and quasielastic light scattering. PMID- 9960402 TI - Capillary-rise study of nonequilibrium wetting by a binary liquid caused by temperature ramps. PMID- 9960401 TI - Light-scattering study of a surface-induced phase transition in alkane fluids. PMID- 9960403 TI - Simulation studies of the faceting transition in a cubic Ising model. PMID- 9960405 TI - Kinetic roughening of a terrace ledge. PMID- 9960404 TI - Phonon dispersion in polycrystalline ice: Implications for the collective behavior of liquid water. PMID- 9960407 TI - Ionization balance in the negative glow of a Hg-Ar hot-cathode discharge. PMID- 9960406 TI - Self-consistent cluster approach to the homogeneous kinetic nucleation theory. PMID- 9960408 TI - Optical probing of hot expanded states produced by shock release. PMID- 9960410 TI - Fast-ion interaction in dense plasmas with two-ion correlation effects. PMID- 9960409 TI - Electronic excitation of the 750- and 811-nm lines of argon. PMID- 9960411 TI - Breaking of resonantly excited electron plasma waves. PMID- 9960412 TI - Plasma-density evolution in compact polyacetal capillary discharges. PMID- 9960413 TI - Dielectric functions for the Vlasov-Landau equation. PMID- 9960414 TI - Helicity, topology, and force-free fields. PMID- 9960415 TI - Electrostatic oscillations in the presence of grain-charge perturbations in dusty plasmas. PMID- 9960417 TI - Plasma broadening of Ne II-Ne VI and F IV-F V spectral lines. PMID- 9960416 TI - Modulational instability dynamics in a spatial focusing and temporal defocusing medium. PMID- 9960418 TI - Spin-depolarization mechanisms due to overlapping spin resonances in synchrotrons. PMID- 9960419 TI - Uniform asymptotic description of ultrashort Gaussian-pulse propagation in a causal, dispersive dielectric. PMID- 9960420 TI - Study of fringing-field effects on the capacitance of a dielectric disk with a circular conducting hole. PMID- 9960421 TI - "Nonlinear" radiation of a sine-Gordon soliton generated by a constant external field. PMID- 9960422 TI - Generalized formula for the first derivative of the electric-field intensity. PMID- 9960424 TI - Continuous time algorithm for Lyapunov exponents. II. PMID- 9960423 TI - Continuous time algorithm for Lyapunov exponents. I. PMID- 9960425 TI - Generalized Forster-Dexter theory of photoinduced intramolecular energy transfer. PMID- 9960426 TI - Stability of the replica-symmetric solution for a perceptron learning from examples. PMID- 9960427 TI - Two-cell correlations in biological tissues. PMID- 9960429 TI - Lattice model for hydrogen bonding and hydration in pure lipid bilayers. PMID- 9960428 TI - Scaling and critical-like behavior in multidimensional diffusive dynamics. PMID- 9960430 TI - Finite-size effects on long-range correlations: implications for analyzing DNA sequences. AB - We analyze the fluctuations in the correlation exponents obtained for noncoding DNA sequences. We find prominent sample-to-sample variations as well as variations within a single sample in the scaling exponent. To determine if these fluctuations may result from finite system size, we generate correlated random sequences of comparable length and study the fluctuations in this control system. We find that the DNA exponent fluctuations are consistent with those obtained from the control sequences having long-range power-law correlations. Finally, we compare our exponents for the DNA sequences with the exponents obtained from power-spectrum analysis and correlation-function techniques, and demonstrate that the original "DNA-walk" method is intrinsically more accurate due to reduced noise. PMID- 9960431 TI - Stochastic resonance in globally coupled nonlinear oscillators. PMID- 9960432 TI - Scaling analysis of Langevin-type equations. PMID- 9960433 TI - Optically induced chaotic behavior in nematic liquid-crystal films. PMID- 9960434 TI - Path-integral formalism for classical Brownian motion in a general environment. PMID- 9960435 TI - Probability distribution function in the gas of paramagnetic particles. PMID- 9960436 TI - Stochastic to deterministic crossover of fractal dimensions for a Langevin equation. PMID- 9960437 TI - Nonclassical A+B-->0 batch reactions: Effect of mobility on rate, order, aggregation and segregation. PMID- 9960438 TI - Modification of the eikonal relation for chemical waves to include fluid flow. PMID- 9960439 TI - Biaxial effect at an isotropic-nematic interface. PMID- 9960440 TI - Nonfractal colloidal aggregation. PMID- 9960442 TI - Simple model of excitable media with dispersion and curvature. PMID- 9960441 TI - Magnitude of the prewetting boundary tension near wetting for short-range forces. PMID- 9960444 TI - Two-dimensional system of charges in cylindrical traps. PMID- 9960443 TI - Relativistic self-focusing of ultraintense laser pulses in inhomogeneous underdense plasmas. PMID- 9960445 TI - Influence of wave dispersion on the self-consistent dynamics of cyclotron-laser type systems. PMID- 9960446 TI - Projection-operator approach to overlap dynamics in a Hopfield network. PMID- 9960447 TI - Deflated regime for pressurized ring polymers with long-range interactions. PMID- 9960449 TI - Transition to hyperchaos in chaotically forced coupled oscillators. PMID- 9960448 TI - Finite-difference scheme to solve Schrodinger equations. PMID- 9960450 TI - Directed polymers in a random medium: Universal scaling behavior of the probability distribution. PMID- 9960451 TI - Hydrodynamic friction of arbitrarily shaped Brownian particles. PMID- 9960452 TI - Spiral-pattern formation in Rayleigh-Benard convection. PMID- 9960453 TI - Kuppers-Lortz transition at high dimensionless rotation rates in rotating Rayleigh-Benard convection. PMID- 9960454 TI - Limited stochastic electron acceleration induced by an intense cyclotron wave in a plasma. PMID- 9960456 TI - Control of chaos in an electrochemical cell. PMID- 9960455 TI - Scattering and wavelength transduction of diffuse photon density waves. PMID- 9960457 TI - Free energy via thermostatted dynamic potential-energy changes. PMID- 9960459 TI - Quantum irregular scattering in the presence of a classical stability island. PMID- 9960458 TI - Thermally activated escape over fluctuating barriers. PMID- 9960460 TI - Multifractal analysis of the galaxy distribution: Reliability of results from finite data sets. PMID- 9960461 TI - Synchronization of chaotic orbits: The effect of a finite time step. PMID- 9960462 TI - Crossover scaling in Scheidegger's river-network model. PMID- 9960463 TI - Characteristic-functional approach to the study of stochastic fluctuations in a model of ionization growth in a discharge gap. PMID- 9960464 TI - Nonlinear relaxation in the presence of an absorbing barrier. PMID- 9960465 TI - Dependence of phase transitions on small changes. PMID- 9960466 TI - Small-angle Krein collisions in a family of four-dimensional reversible maps. PMID- 9960468 TI - Ising model in an oscillating magnetic field: Mean-field theory. PMID- 9960467 TI - Stochastic resonance as a crisis in a period-doubled circuit. PMID- 9960469 TI - Thermodynamics and transport properties of n-butane computed by molecular dynamics using a rigid interaction model. PMID- 9960470 TI - Calculating Lyapunov exponents for short and/or noisy data sets. PMID- 9960471 TI - Mean first-passage time for systems driven by pre-Gaussian noise: Natural boundary conditions. PMID- 9960472 TI - Structural changes accompanying densification of random hard-sphere packings. PMID- 9960473 TI - Statistical mechanics of a Hopfield neural-network model in a transverse field. PMID- 9960474 TI - First-passage times and solutions of the telegrapher equation with boundaries. PMID- 9960475 TI - Probability distributions and escape rates for systems driven by quasimonochromatic noise. PMID- 9960476 TI - Information and entropy. PMID- 9960477 TI - Diffusive dynamics of deposition-evaporation systems, jamming, and broken symmetries in related quantum-spin models. PMID- 9960478 TI - Model for coarsening froths and foams. PMID- 9960480 TI - Modeling chaotic quantum systems by tridiagonal random matrices. PMID- 9960479 TI - Mean first-passage time in the presence of telegraph noise and the Ornstein Uhlenbeck process. PMID- 9960481 TI - Relaxation and stationary properties of a nonlinear system driven by white shot noise: An exactly solvable model. PMID- 9960482 TI - Diffusion in liquids from a first-passage-time point of view. PMID- 9960483 TI - Positron lifetime distributions in fluids. PMID- 9960484 TI - Weighted-density-functional theory of nonuniform ionic fluids: Application to electric double layers. PMID- 9960485 TI - Velocity correlations in a one-dimensional lattice gas: Theory and simulations. PMID- 9960486 TI - Behavior of entropy in hyperbolic heat conduction. PMID- 9960487 TI - Anderson localization and solitonic energy transport in one-dimensional oscillatory systems. PMID- 9960488 TI - Liquid structure of the alkaline-earth metals. PMID- 9960489 TI - Experimental observation of the quasiperiodic modes in a rotating Couette system. PMID- 9960490 TI - Breakdown of shock-wave-structure solutions. PMID- 9960492 TI - Ordering and finite-size effects in the dynamics of one-dimensional transient patterns. PMID- 9960491 TI - Evolution of patterns in the anisotropic complex Ginzburg-Landau equation: Modulational instability. PMID- 9960493 TI - Crossover of spectral scaling in thermal turbulence. PMID- 9960495 TI - Finite-time singularity formation in Hele-Shaw systems. PMID- 9960494 TI - Droplet breakup in a model of the Hele-Shaw cell. PMID- 9960497 TI - Connection between integrated intensities of depolarized-light-scattering spectra and mesoscopic order in liquids. PMID- 9960496 TI - Weakly to strongly structured mixtures. PMID- 9960498 TI - Molecular clusters and correlations in water by x-ray and neutron diffraction. PMID- 9960500 TI - Monte Carlo study of polymer chains end-grafted onto a spherical interface. PMID- 9960499 TI - Light-scattering spectroscopy of the liquid-glass transition in CaKNO3 and in the molecular glass Salol: Extended-mode-coupling-theory analysis. PMID- 9960501 TI - Lattice Bhatnagar-Gross-Krook models for miscible fluids. PMID- 9960502 TI - Phase behavior of dense three-component ionic microemulsions and electrical conductivity in the lamellar phase. PMID- 9960503 TI - Time-dependent correlation functions in a one-dimensional asymmetric exclusion process. PMID- 9960504 TI - Associating-polymer effects in a Hele-Shaw experiment. PMID- 9960505 TI - Perturbation weighted-density approximation: The phase diagram of a Lennard-Jones system. PMID- 9960506 TI - Ginzburg-Landau theory of ternary amphiphilic systems. I. Gaussian interface fluctuations. PMID- 9960507 TI - Ginzburg-Landau theory of ternary amphiphilic systems. II. Monte Carlo simulations. PMID- 9960508 TI - Array of doublets: A branch of cellular solutions in directional solidification. PMID- 9960510 TI - Thermal energy of the crystalline one-component plasma from dynamical simulations. PMID- 9960509 TI - Validity of the effective temperature scale for a dilute Li+ swarm in a Xe gas. PMID- 9960511 TI - Nonlinear radiative-condensation instability and pattern formation: One dimensional dynamics. PMID- 9960513 TI - Linear waves in relativistic anisotropic magnetohydrodynamics. PMID- 9960512 TI - X-ray emission from a 650-fs laser-produced barium plasma. PMID- 9960514 TI - Concise expression of a classical radiation spectrum. PMID- 9960515 TI - Linear and nonlinear theory of gyroharmonic radiation into modes of a cylindrical waveguide from spatiotemporally modulated electron beams. PMID- 9960516 TI - Transition to stochasticity in the relativistic and the nonrelativistic versions of a dynamical system. PMID- 9960517 TI - Various characteristics of a waveguide-mode free-electron laser using a long pulse relativistic electron beam. PMID- 9960518 TI - Perturbation expansion for particle distributions in hadron storage rings. PMID- 9960519 TI - Analysis of the saturation of a high-gain free-electron laser. PMID- 9960520 TI - Continua of localized wave solutions via a complex similarity transformation. PMID- 9960521 TI - Spherical wave functions and dyadic Green's functions for homogeneous elastic anisotropic media. PMID- 9960522 TI - Asymptotic behavior of one-dimensional nonlinear discrete kink-bearing systems in the continuum limit: Problems of nonuniform convergence. PMID- 9960523 TI - Cooling schedules for learning in neural networks. PMID- 9960524 TI - Neural networks optimally trained with noisy data. PMID- 9960525 TI - Dynamics of an A-DNA homopolymer crystal with sodium ions: A Green-function approach. PMID- 9960526 TI - "Cavity-approach" analysis of the neural-network learning problem. PMID- 9960527 TI - Generalized Levy-walk model for DNA nucleotide sequences. AB - We propose a generalized Levy walk to model fractal landscapes observed in noncoding DNA sequences. We find that this model provides a very close approximation to the empirical data and explains a number of statistical properties of genomic DNA sequences such as the distribution of strand-biased regions (those with an excess of one type of nucleotide) as well as local changes in the slope of the correlation exponent alpha. The generalized Levy-walk model simultaneously accounts for the long-range correlations in noncoding DNA sequences and for the apparently paradoxical finding of long subregions of biased random walks (length lj) within these correlated sequences. In the generalized Levy-walk model, the lj are chosen from a power-law distribution P(lj) varies as lj(-mu). The correlation exponent alpha is related to mu through alpha = 2-mu/2 if 2 < mu < 3. The model is consistent with the finding of "repetitive elements" of variable length interspersed within noncoding DNA. PMID- 9960528 TI - Analog neural networks with local competition. I. Dynamics and stability. PMID- 9960529 TI - Analog neural networks with local competition. II. Application to associative memory. PMID- 9960530 TI - Signatures of quantum chaos in Wigner and Husimi representations. PMID- 9960531 TI - Quasicrossing distribution as a signature of the onset of chaos in the SU(3) nuclear model. PMID- 9960532 TI - Cycles and circles in roundoff errors. PMID- 9960533 TI - Brownian-particle trapping by clusters of traps. PMID- 9960534 TI - Exact evaluation of diffusion dynamics in a potential well with a general delocalized sink. PMID- 9960535 TI - Growth of interfaces with a conservation law and spatial-temporal correlations. PMID- 9960536 TI - Onset of spatiotemporal intermittency in a coupled-map lattice. PMID- 9960537 TI - Simple stochastic model for resonant activation. PMID- 9960538 TI - Self-organized criticality in 4He with a heat current. PMID- 9960540 TI - Modifying the onset of homoclinic chaos: Application to a bistable potential. PMID- 9960539 TI - Bethe lattices in hyperbolic space. PMID- 9960541 TI - Wind-tree model in two dimensions with internal degrees of freedom: Exact solution. PMID- 9960542 TI - Two-dimensional evolution of surface gravity waves on a fluid of arbitrary depth. PMID- 9960543 TI - Instability mechanism at driven contact lines. PMID- 9960545 TI - Rigidity and connectivity percolation in heterogeneous polymer-fluid networks. PMID- 9960544 TI - Spin-lattice relaxation of polymers: The memory-function formalism. PMID- 9960547 TI - Calculating the helical twisting power of dopants in a liquid crystal by computer simulation. PMID- 9960546 TI - Hyperscaling and nonclassical exponents for the line tension at wetting. PMID- 9960549 TI - Perturbation theory in the exact linearized kinetic equation for a plasma. PMID- 9960548 TI - Interference of phase separation and gelation: A zeroth-order kinetic model. PMID- 9960550 TI - Total backward reflection of electromagnetic radiation due to resonant excitation of surface waves. PMID- 9960552 TI - Comment on "Suppression of chaos by resonant parametric perturbations" PMID- 9960551 TI - Explosive free-electron-laser instability in a plasma-filled waveguide. PMID- 9960553 TI - Reply to "Comment on 'Suppression of chaos by resonant parametric perturbations' " PMID- 9960554 TI - Erratum: Third-frequency-moment sum rule and long-wavelength plasmon dispersion in layered electron liquids PMID- 9960555 TI - Quasiperiodic structure of the stochastic web map. PMID- 9960556 TI - Abelian sandpile model. PMID- 9960557 TI - Solitons and 1/f noise in molecular chains. PMID- 9960559 TI - Exact solution of an infinite class of stochastic models describing random sequential adsorption and other irreversible processes. PMID- 9960558 TI - Level-spacing distribution of a singular billiard. PMID- 9960560 TI - Head-on collision between two solitary waves in a Rayleigh-Benard convecting fluid. PMID- 9960561 TI - Concentration fluctuations of a binary liquid mixture in a macroporous glass. PMID- 9960562 TI - Transitions and instabilities in liquid crystal elastomers. PMID- 9960563 TI - Counterpropagating periodic pulses in coupled Ginzburg-Landau equations. PMID- 9960564 TI - Pulse propagation in optical fibers near the zero dispersion point. PMID- 9960565 TI - Hybrid Monte Carlo method for conserved-order-parameter systems. PMID- 9960566 TI - Application of the non-Markovian Fokker-Planck equation to the resonant activation of a Josephson junction. PMID- 9960567 TI - Catalysis at single-crystal Pt(110) surfaces: Global coupling and standing waves. PMID- 9960568 TI - Equivalence of thermostatted nonlinear responses. PMID- 9960569 TI - Annihilation reactions in two-dimensional percolation clusters: Effects of short range interactions. PMID- 9960570 TI - Effective-eigenvalue approach to the nonlinear Langevin equation for the Brownian motion in a tilted periodic potential: Application to the Josephson tunneling junction. PMID- 9960571 TI - Multifunctional variational method for description of evolution and dynamics of dissipative structures in nonequilibrium systems. PMID- 9960572 TI - Chaos and order in a kicked anharmonic oscillator: Classical and quantum analysis. PMID- 9960573 TI - Systems near a critical point under multiplicative noise and the concept of effective potential. PMID- 9960574 TI - Second-order dichotomous processes: Damped free motion, critical behavior, and anomalous superdiffusion. PMID- 9960575 TI - Classification criterion for dynamical systems in intermittent chaos. PMID- 9960576 TI - Universality of zero-dispersion peaks in the fluctuation spectra of underdamped nonlinear oscillators. PMID- 9960577 TI - From self-organized criticality to first-order-like behavior: A new type of percolative transition. PMID- 9960578 TI - Manifolds in random media: Multifractal behavior. PMID- 9960580 TI - Necessary condition of the Turing instability. PMID- 9960579 TI - Ordered and chaotic behavior of two coupled van der Pol oscillators. PMID- 9960581 TI - Motions of spiral waves in oscillatory media and in the presence of obstacles. PMID- 9960582 TI - Crises-induced intermittencies in a coherently driven system of two-level atoms. PMID- 9960583 TI - Stokes-Einstein violation in glass-forming liquids. PMID- 9960585 TI - Transport coefficients of hard-sphere mixtures. III. Diameter ratio 0.4 and mass ratio 0.03 at high fluid density. PMID- 9960584 TI - Evidence of kinetic effects in liquid PMID- 9960586 TI - Ornstein-Zernike equations and simulation results for hard-sphere fluids adsorbed in porous media. PMID- 9960588 TI - Heat and momentum transport in a gaseous dilute solution. PMID- 9960587 TI - Generalized hydrodynamics and dispersion relations in lattice gases. PMID- 9960589 TI - Rayleigh-Benard problem with imposed weak through-flow: Two coupled Ginzburg Landau equations. PMID- 9960590 TI - Bridging between eddy-viscosity-type and second-order turbulence models through a two-scale turbulence theory. PMID- 9960591 TI - Local anisotropic effects on multifractality of turbulence. PMID- 9960592 TI - Spatiotemporal intermittency in lines of vortices. PMID- 9960593 TI - Numerical construction of nonlinear wave-train solutions of the periodic Korteweg de Vries equation. PMID- 9960594 TI - Purely global model for Taylor dispersion. PMID- 9960595 TI - Spatial anisotropy of velocity fluctuations on small length scales in a Taylor Couette cell. PMID- 9960596 TI - High-field magnetic birefringence study of the phase behavior of concentrated solutions of phospholipid tubules. PMID- 9960598 TI - Viscoelastic interfacial modes in a wetting layer. PMID- 9960597 TI - Deuterium NMR of a pentylcyanobiphenyl liquid crystal confined in a silica aerogel matrix. PMID- 9960599 TI - Experimental studies of the rheology of a simple liquid mixture during phase separation. PMID- 9960600 TI - Phase transitions in diblock copolymers: Theory and Monte Carlo simulations. PMID- 9960602 TI - Langevin models for shear-stress fluctuations in flows of viscoelastic liquids. PMID- 9960601 TI - Ultrasonic measurements of an epoxy resin near its sol-gel transition. PMID- 9960603 TI - Effect of free surfaces on the smectic-A-hexatic-B-crystal-E transitions in thin free-standing films of the liquid-crystal compound n-heptyl-4'-n pentyloxybiphenyl-4-carboxylate (75OBC). PMID- 9960605 TI - Optical phase shift of polymer-dispersed liquid crystals. PMID- 9960604 TI - Hexatic and fat-fractal structures for water droplets condensing on oil. PMID- 9960606 TI - Models of crack propagation. II. Two-dimensional model with dissipation on the fracture surface. PMID- 9960607 TI - Concentration dependence of long-time tails in colloidal suspensions. PMID- 9960608 TI - Theoretical investigation of the behavior of ferroelectric liquid crystals in a magnetic or in a high-frequency electric field. PMID- 9960609 TI - Phase diagram of random copolymers. PMID- 9960610 TI - Effect of a critical field on screened dielectric-breakdown growth. PMID- 9960611 TI - Exact solution of a generalized ballistic-deposition model. PMID- 9960612 TI - Dendritic sidebranching with periodic localized perturbations: Directional solidification of pivalic acid-coumarin 152 mixtures. PMID- 9960614 TI - Nonlinear heat structures and arc-discharge electrode spots. PMID- 9960613 TI - Contributions of strong collisions in the theory of spectral lines. PMID- 9960616 TI - Space-charge divergence of an intense, unneutralized rectangular ion beam. PMID- 9960615 TI - Surface-wave propagation along the boundary of a plasma with nonlocal anisotropic electric properties. PMID- 9960617 TI - Minimal normal-form method for discrete maps. PMID- 9960619 TI - Kink dynamics in the periodically modulated phi4 model. PMID- 9960618 TI - Discrete C-caronerenkov power spectrum. PMID- 9960621 TI - Dynamics and interaction of solitons on an integrable inhomogeneous lattice. PMID- 9960620 TI - Elastic scattering and energy theorems for a doubly periodic planar array of elastic obstacles. PMID- 9960623 TI - Kinklike excitations as an energy-transfer mechanism in microtubules. PMID- 9960622 TI - Skin layer of diffusive media. PMID- 9960624 TI - Mitosis and growth in biological tissues. PMID- 9960625 TI - Poisson's ratio in polymer gels near the phase-transition point. PMID- 9960626 TI - Stochastic fields on a lattice. PMID- 9960628 TI - Dependence of percolation thresholds on lattice connectivity. PMID- 9960627 TI - Breaking of forward-backward symmetry in driven systems. PMID- 9960629 TI - Equivalence of two free-energy models for the inhomogeneous hard-sphere fluid. PMID- 9960630 TI - Nucleation-limited aggregation in fractal growth. PMID- 9960631 TI - Temperature dependence of XY-like order parameters in thin free-standing smectic liquid-crystal films. PMID- 9960633 TI - Evanescent-mode propagation and quantum tunneling. PMID- 9960632 TI - Electric-field-dependent thermal fluctuations of giant vesicles. PMID- 9960634 TI - Erratum: Self-consistent approach to the Kardar-Parisi-Zhang equation PMID- 9960636 TI - Fluctuational distribution function of solitons in the nonlinear Schrodinger system. PMID- 9960635 TI - Nearly-second-order nematic-isotropic phase transition in a cyclic thermotropic liquid crystal. PMID- 9960637 TI - Formation of asymmetric states of spiral waves in oscillatory media. PMID- 9960638 TI - Determination of the noise level of chaotic time series. PMID- 9960639 TI - Interaction of a relaxing system with a dynamical environment. PMID- 9960640 TI - Self-organized criticality in a stochastic spring-block model. PMID- 9960641 TI - Conserved dynamics of a two-dimensional random-field model. PMID- 9960643 TI - Scaling of structure functions. PMID- 9960642 TI - Extended self-similarity in turbulent flows. PMID- 9960644 TI - One modification to the Yakhot-Orszag calculation in the renormalization-group theory of turbulence. PMID- 9960645 TI - Field-driven first-order structural transition in the restricted geometry of a smectic-A cell. PMID- 9960646 TI - Intrinsic localized modes as solitons with a compact support. PMID- 9960647 TI - Fluctuations in self-organizing systems. PMID- 9960648 TI - Effective-eigenvalue approach to the nonlinear Langevin equation for the Brownian motion in a tilted periodic potential. II. Application to the ring-laser gyroscope. PMID- 9960649 TI - Domain walls in nonequilibrium systems and the emergence of persistent patterns. PMID- 9960650 TI - Stabilizing chaotic-scattering trajectories using control. PMID- 9960651 TI - Stochastic tracking in nonlinear dynamical systems. PMID- 9960652 TI - Thermodynamic behavior of chains on the Bethe lattice. PMID- 9960653 TI - Anomalous diffusion in dynamical systems: Transport coefficients of all order. PMID- 9960655 TI - Collective phenomena in large populations of globally coupled relaxation oscillators. PMID- 9960654 TI - Surface adsorption and the collapse transition of a linear polymer chain: Some exact results on fractal lattices. PMID- 9960657 TI - Quantum spinodal decomposition. PMID- 9960656 TI - Cellular-automata studies of circular Couette flows and chaotic mixing. PMID- 9960658 TI - Generalized error propagation in one-dimensional chaotic systems. PMID- 9960659 TI - Compressible dynamics, time reversibility, Maxwell's demon, and the second law. PMID- 9960660 TI - Period doubling in coupled maps. PMID- 9960661 TI - Three-point correlation functions in uniformly and randomly driven diffusive systems. PMID- 9960662 TI - Photon path-length distributions for transmission through optically turbid slabs. PMID- 9960663 TI - Increase-in-entropy law. PMID- 9960664 TI - Diffusion-controlled bimolecular reactions: Long- and intermediate-time regimes with imperfect trapping within a Galanin approach. PMID- 9960666 TI - Further aspects of an interpolative quantum statistics. PMID- 9960665 TI - Wave propagation and quantum superdiffusion in a rapidly varying random potential. PMID- 9960667 TI - Crossover from rate-equation to diffusion-controlled kinetics in two-particle coagulation. PMID- 9960669 TI - Correlations, mean-field properties, and scaling of a one-dimensional sandpile model. PMID- 9960668 TI - Stochastic equations of motion for epitaxial growth. PMID- 9960671 TI - Difficulties in using averaged orbits to extract scaling functions. PMID- 9960670 TI - Self-consistent signal-to-noise analysis of the statistical behavior of analog neural networks and enhancement of the storage capacity. PMID- 9960672 TI - Limitations of delay reconstruction for chaotic dynamical systems. PMID- 9960673 TI - Irreversible phase transitions in a surface-reaction model with diffusion- and adsorption-limited reactions. PMID- 9960674 TI - Thermodynamics of driven systems. PMID- 9960676 TI - Solution to the telegrapher's equation in the presence of reflecting and partly reflecting boundaries. PMID- 9960675 TI - Escape problem for irreversible systems. PMID- 9960678 TI - Mean first-passage times for systems driven by the coin-toss square wave. PMID- 9960677 TI - Controlling chaos in a network of oscillators. PMID- 9960679 TI - Linear-solvability condition in the Saffman-Taylor problem. PMID- 9960680 TI - Nonlinear quantum dynamics at a classical second-order resonance. PMID- 9960681 TI - Exact scaling in surface growth with power-law noise. PMID- 9960682 TI - Lattice-gas automata with attractive and repulsive interactions. PMID- 9960683 TI - Neutron-diffraction determination of the microscopic structure of liquid deuterium. PMID- 9960684 TI - Scale-invariant regime in Rayleigh-Taylor bubble-front dynamics. PMID- 9960685 TI - Small-scale intermittency in randomly stirred fluids. PMID- 9960686 TI - Structure of hard-turbulent convection in two dimensions: Numerical evidence. PMID- 9960687 TI - Stability of Taylor-Dean flow in an annulus with arbitrary gap spacing. PMID- 9960688 TI - Interface growth and Burgers turbulence: The problem of random initial conditions. PMID- 9960690 TI - Thermal conductivity of a shearing fluid. PMID- 9960689 TI - Benard-Marangoni convective patterns in small cylindrical layers. PMID- 9960691 TI - Effect of gravity on stable Saffman-Taylor fingers. PMID- 9960693 TI - Orientational relaxation in a colloidal suspension of spheres. PMID- 9960692 TI - Fluctuations and light scattering in thin smectic films. PMID- 9960694 TI - New broken-parity state and a transition to anomalous lamellae in eutectic growth. PMID- 9960695 TI - Coherent crystallography of shear-aligned crystals of hard-sphere colloids. PMID- 9960696 TI - Theory of a symmetry-breaking phase transition in a surface layer of nematic liquid crystal. PMID- 9960697 TI - Bend and splay elastic constants of diheptylazoxybenzene. PMID- 9960699 TI - Kerr effect and the nonlinear dielectric effect on approaching the critical consolute point. PMID- 9960698 TI - Critical droplets on a wall near a first-order wetting transition. PMID- 9960700 TI - Orientational relaxation in a colloidal Heisenberg model. PMID- 9960702 TI - Theoretical analysis of actual surfaces: The effect on the nematic orientation. PMID- 9960701 TI - Weighted-density-functional theory of electrode-electrolyte interface: Beyond the primitive model. PMID- 9960703 TI - Experiments and analysis of combined diffraction and self-diffraction effects in a nematic-liquid-crystal cell. PMID- 9960704 TI - Macroscopic description of the kinetics of swelling for a cross-linked elastomer or a gel. PMID- 9960705 TI - Locating the nonergodicity-parameter anomaly near the liquid-to-glass crossover temperature in CaKNO3 by Brillouin scattering. PMID- 9960706 TI - Perturbed spectra of glasslike chains. PMID- 9960707 TI - Fluid-flow-induced pattern formation in liquid crystals in a rotating magnetic field. PMID- 9960708 TI - Dynamic relaxation of drifting polymers: A phenomenological approach. PMID- 9960709 TI - Monte Carlo study of polymer adsorption from dilute solutions. PMID- 9960710 TI - Phenomenological approach to the problem of the K13 surfacelike elastic term in the free energy of a nematic liquid crystal. PMID- 9960711 TI - Distortions induced by the K13 surfacelike elastic term in a thin nematic liquid crystal film. PMID- 9960712 TI - Effect of quenched and correlated disorder on growth phenomena. PMID- 9960714 TI - Growth and forms of Laplacian aggregates. PMID- 9960713 TI - Coupling of drift, diffusion, and electroconvection, in the vicinity of growing electrodeposits. PMID- 9960715 TI - Localization of growth sites in diffusion-limited-aggregation clusters: Multifractality and multiscaling. PMID- 9960716 TI - One-dimensional, weakly nonlinear electromagnetic solitary waves in a plasma. PMID- 9960717 TI - Dynamics and stability of an expanding laser-induced plasma in a low-density gas. PMID- 9960718 TI - Transport properties of Na+ ions in Kr gas. PMID- 9960719 TI - Filamentation effects and second-harmonic spectra in laser-produced plasmas. PMID- 9960720 TI - Equations of state and phase diagrams for dense multi-ionic mixture plasmas. PMID- 9960721 TI - Analytic solutions of the time-dependent quasilinear diffusion equation with source and loss terms. PMID- 9960722 TI - Spectroscopic investigation of fluctuating anisotropic electric fields in a high power-diode plasma. PMID- 9960723 TI - Charged-hard-sphere system: A self-consistent-field approximation. PMID- 9960724 TI - Low-temperaure O2- mobility in high-density neon gas. PMID- 9960725 TI - Application of the Fokker-Planck equation to particle-beam injection into e- storage rings. PMID- 9960727 TI - Pair creation by photons in the field of an electron or positron pulse of high density. PMID- 9960726 TI - Saturation and cavity-loss optimization in free-electron lasers. PMID- 9960728 TI - Spherical scattering of superpositions of localized waves. PMID- 9960729 TI - Resonant shape oscillations and decay of a soliton in a periodically inhomogeneous nonlinear optical fiber. PMID- 9960730 TI - Boundary conditions in electromagnetics. PMID- 9960731 TI - Nonlinear instabilities relating to negative-energy modes. PMID- 9960732 TI - Green's function of the electromagnetic field in biaxial media. PMID- 9960733 TI - Length-scale competition in the damped sine-Gordon chain with spatiotemporal periodic driving. PMID- 9960734 TI - Anomalous pulse delay in microwave propagation: A plausible connection to the tunneling time. PMID- 9960735 TI - DNA denaturation as a problem of translational-symmetry restoration. PMID- 9960736 TI - Toy model for protein folding. PMID- 9960737 TI - Scanning photoemission spectromicroscopy of neurons. PMID- 9960738 TI - Asynchronous states in networks of pulse-coupled oscillators. PMID- 9960739 TI - Effects of particle shape on electromagnetic torques: A comparison of the effective-dipole-moment method with the Maxwell-stress-tensor method. PMID- 9960740 TI - Neural network and wavelet transform for scale-invariant data classification. PMID- 9960741 TI - Optimal neural networks for protein-structure prediction. PMID- 9960742 TI - Theoretical models of energy transfer in two-dimensional molecular assemblies. PMID- 9960743 TI - Nonlinear noise reduction: A case study on experimental data. PMID- 9960744 TI - Numerical solutions of first-exit-time problems. PMID- 9960745 TI - Energy balance for a dissipative system. PMID- 9960746 TI - Physical meaning of the time-correlation length obtained in a computer simulation. PMID- 9960747 TI - Prototype for memory effects in the time evolution of damage. PMID- 9960748 TI - Closed-form solution for inverse problems of Fermi systems. PMID- 9960750 TI - Effective viscosity in a Levy-walk model for turbulent channel flow. PMID- 9960749 TI - Extracting energy and heat from the vacuum. PMID- 9960751 TI - Chemical wave front in two dimensions. PMID- 9960753 TI - Roughness exponents: A paradox resolved. PMID- 9960752 TI - Density profile in convection of water near 4 degreesC. PMID- 9960754 TI - Asymptotic crossover in polymer blends. PMID- 9960755 TI - Comparison of two free-energy expressions and their implications in surface enrichment. PMID- 9960757 TI - Stochastic motion of charged particles in a magnetic field. PMID- 9960756 TI - Anisotropies in aggregates with biased random walks on two-dimensional lattices. PMID- 9960758 TI - Exact solution of an electron kinetic equation for a strongly nonisothermal two component plasma. PMID- 9960759 TI - Intrinsic linewidth of a free-electron laser with an axial-guide magnetic field. PMID- 9960760 TI - Erratum: Microscopic expressions for interfacial bending constants and spontaneous curvature PMID- 9960761 TI - Erratum: Perturbing Hele-Shaw flow with a small gap gradient PMID- 9960762 TI - Deterministic origin of 1/f noise in magnetic resonance. PMID- 9960763 TI - Scale invariance of nonconserved quantities in driven systems. PMID- 9960764 TI - Computer simulation of the spinodal decomposition for a polydisperse polymer mixture. PMID- 9960765 TI - Scaling behavior of self-avoiding tethered vesicles. PMID- 9960767 TI - Exact solutions for Hele-Shaw flows with surface tension: The Schwarz-function approach. PMID- 9960766 TI - Random walker and the telegrapher's equation: A paradigm of a generalized hydrodynamics. PMID- 9960768 TI - Measurement of reflection of traveling waves near the onset of binary-fluid convection. PMID- 9960769 TI - Coexisting traveling waves and steady rolls in binary-fluid convection. PMID- 9960770 TI - Law of space decorrelation for developed hydrodynamic turbulence. PMID- 9960771 TI - Bubbles and stripes in dipolar fluids. PMID- 9960772 TI - Space-time evolution of a beam-plasma instability in strongly correlated plasmas. PMID- 9960773 TI - Experimental relation between particle and energy confinement in reversed-field pinches. PMID- 9960774 TI - Non-self-similar collapsing solutions of the nonlinear Schrodinger equation at the critical dimension. PMID- 9960776 TI - Type-I intermittency for the Henon-map family. PMID- 9960775 TI - Stationary probability distribution near stable limit cycles far from Hopf bifurcation points. PMID- 9960778 TI - Geometric mechanism for antimonotonicity in scalar maps with two critical points. PMID- 9960777 TI - Quadratic map modulated by additive periodic forcing. PMID- 9960779 TI - Self-similar transport in incomplete chaos. PMID- 9960780 TI - Nonequilibrium thermodynamics of nonlinear diffusion flux in a nonideal electrolyte solution. PMID- 9960781 TI - Stochastic model for complex surface-reaction systems with application to NH3 formation. PMID- 9960783 TI - Applicability of Nose isothermal reversible dynamics. PMID- 9960782 TI - Nonequilibrium phase transitions in systems with infinitely many absorbing states. PMID- 9960785 TI - Ising model with isotropic competing interactions in the presence of a field: A tricritical-Lifshitz-point realization. PMID- 9960784 TI - Competing dynamics in the one-dimensional Blume-Emery-Griffiths model: Hydrodynamic equations. PMID- 9960786 TI - Noise reduction in chaotic time-series data: A survey of common methods. PMID- 9960788 TI - Long-range polarization interaction in simple liquid metals. PMID- 9960787 TI - Symmetry breaking and localization in quantum chaotic systems. PMID- 9960789 TI - Nonlinear hydrodynamics of a hard-sphere fluid near the glass transition. PMID- 9960790 TI - Thermal equilibration near the critical point: Effects due to three dimensions and gravity. PMID- 9960791 TI - Experimental observation of thermoacoustic turbulence and universal properties at the quasiperiodic transition to chaos. PMID- 9960792 TI - Generalized compressibility equation for inhomogeneous fluids at equilibrium. PMID- 9960794 TI - Specific heats of saturated water vapor and liquid. PMID- 9960793 TI - Renormalization group and operator product expansion in turbulence: Shell models. PMID- 9960795 TI - Thermodynamic functions for Taylor dispersion. PMID- 9960797 TI - Oblique collision of two vortex rings and its acoustic emission. PMID- 9960796 TI - Hamiltonian formulation for the motion of vortices in the presence of a free surface for ideal flow. PMID- 9960798 TI - Phase transitions of a confined complex fluid. PMID- 9960800 TI - Phase-field and sharp-interface alloy models. PMID- 9960799 TI - Correlation between surface and bulk orientations of liquid crystals on rubbed polymer surfaces: Odd-even effects of polymer spacer units. PMID- 9960801 TI - Diffusion of a reptating polymer interacting with a random matrix. PMID- 9960802 TI - Destruction of a first-order smectic-A-->smectic-C* phase transition by dimensional crossover in free-standing films. PMID- 9960803 TI - Analytic theory for parity breaking in lamellar eutectic growth. PMID- 9960804 TI - Splay-bend curvature and temperature-induced surface transitions in nematic liquid crystals. PMID- 9960805 TI - Half widths of neutron spectra in dense helium-neon gas mixtures. PMID- 9960806 TI - Surface critical exponents of self-avoiding walks on a square lattice with an adsorbing linear boundary: A computer simulation study. PMID- 9960807 TI - Character of the smectic-A-chiral-smectic-C phase transition near a chiral nematic-smectic-A-chiral-smectic-C point. PMID- 9960808 TI - Viscosities of concentrated dispersions. PMID- 9960809 TI - Dispersion relation around a kink solution in binary fluids undergoing spinodal decomposition. PMID- 9960810 TI - Reversible flocculation of silica colloids in liquid mixtures. PMID- 9960812 TI - Surface molecular anchoring in microconfined liquid crystals near the nematic smectic-A transition. PMID- 9960811 TI - van der Waals forces in electrorheological fluids. PMID- 9960813 TI - Self-consistent-field calculation of structures and static properties of the solid-fluid interface: Paraffinlike molecule systems. PMID- 9960815 TI - Scaling properties of soft-core parallel spherocylinders near the crystal-smectic phase transition. PMID- 9960814 TI - Phase-field models for anisotropic interfaces. PMID- 9960817 TI - Long-range interactions and the pair-correlation function in dipolar main-chain nematic polymers. PMID- 9960816 TI - Anomalous crystal growth of a binary chain. PMID- 9960818 TI - Stroboscopic microscopy of ferroelectric liquid crystals. PMID- 9960820 TI - Dynamic and static correlations in model Coulomb systems. PMID- 9960819 TI - Nonlinear-electron-response impact on the evolution of ion-acoustic wave packets in a magnetized plasma. PMID- 9960821 TI - Modeling of plasma dynamics in x-ray-confining cavities. PMID- 9960823 TI - Observation of plasma confinement in picosecond laser-plasma interactions. PMID- 9960822 TI - Electron distribution functions in laser-embedded plasmas. PMID- 9960824 TI - Melting phenomenon in laser-induced shock waves. PMID- 9960825 TI - Anomalous fast recombination in hydrogen plasmas involving rovibrational excitation. PMID- 9960826 TI - Experimental loss rates due to emission from Ne, Ar, and Xe ions at high plasma densities. PMID- 9960827 TI - Transport coefficients of quantum plasmas. PMID- 9960828 TI - Isotope effect and electron-temperature dependence in volume H- and D- ion sources. PMID- 9960829 TI - Bound for the pressure integral in a toroidal-plasma equilibrium. PMID- 9960830 TI - Nonlinear ion-acoustic waves in a collisional plasma. PMID- 9960831 TI - Moments and characteristic function of a nonstationary particle distribution after injection. PMID- 9960832 TI - Quasi-isochronous storage rings. PMID- 9960833 TI - Enhanced acceleration in a self-modulated-laser wake-field accelerator. PMID- 9960835 TI - Recursive solution of Maxwell's equations. PMID- 9960834 TI - Nonlinear short-pulse propagation in a free-electron laser. PMID- 9960836 TI - Instability due to cross-phase modulation in the normal-dispersion regime. PMID- 9960837 TI - Harmonic plane waves in a chiral slab. PMID- 9960838 TI - Subharmonic steps and inertial effects in a system of two coupled overdamped oscillators. PMID- 9960839 TI - Metaplectic formulation of linear mode conversion. PMID- 9960840 TI - Effects due to geometry and boundary conditions in multiple light scattering. PMID- 9960841 TI - Soliton growth-signal transduction in topologically quantized T cells. PMID- 9960842 TI - Breaking of replica symmetry in a mean-field model of disordered membranes. PMID- 9960843 TI - Vibrational dynamics of wet-spun films of the NaDNA-netropsin complex: A Raman and infrared study. PMID- 9960844 TI - Vanishing thermal damping of Davydov's solitons. PMID- 9960845 TI - Mixture states and storage of biased patterns in Potts-glass neural networks. PMID- 9960847 TI - Sequence-structure relationships in proteins and copolymers. PMID- 9960846 TI - Master-equation approach to stochastic neurodynamics. PMID- 9960848 TI - Stochastic generation of homogeneous isotropic turbulence with well-defined spectra. PMID- 9960850 TI - Failure of microemulsion models to exhibit a triple line in two dimensions. PMID- 9960849 TI - Numerical study of a high-order quasiconserved quantity in the Henon-Heiles problem. PMID- 9960851 TI - Liquid-crystalline blue phase III and structures of broken icosahedral symmetry. PMID- 9960853 TI - Counterexample to some shape equations for axisymmetric vesicles. PMID- 9960854 TI - Hydrodynamics of collisional structures in laser-produced plasmas. PMID- 9960852 TI - Neutron scattering from polycrystalline ice (Ih): Some keys to understanding the collective behavior of liquid water. PMID- 9960856 TI - Effect of two-photon absorption on the amplification of ultrashort optical pulses. PMID- 9960855 TI - Bright-dark solitary-wave solutions of a multidimensional nonlinear Schrodinger equation. PMID- 9960857 TI - Comment on "Surface-tension-anisotropy measurements of succinonitrile and pivalic acid: Comparison with microscopic solvability theory" PMID- 9960858 TI - Statistical properties of spatiotemporal dynamical systems. PMID- 9960861 TI - Disturbing the random-energy landscape. PMID- 9960859 TI - Towards a systematic calculation of the scaling functions for the ordering kinetics of nonconserved fields. PMID- 9960860 TI - Band-random-matrix model for quantum localization in conservative systems. PMID- 9960862 TI - Synchronization of chaotic orbits: The influence of unstable periodic orbits. PMID- 9960863 TI - Transmission of signals by synchronization in a chaotic Van der Pol-Duffing oscillator. PMID- 9960864 TI - Accelerating chemical waves accompanied by traveling hydrodynamic motion and surface deformation. PMID- 9960865 TI - Gradient flexoelectric effect and thickness dependence of anchoring energy. PMID- 9960866 TI - Turbulence due to spiral breakup in a continuous excitable medium. PMID- 9960868 TI - Measurement of the persistence length of polymerized actin using fluorescence microscopy. PMID- 9960867 TI - Experimental measurement of resonance islands induced by rf voltage modulation. PMID- 9960869 TI - Driven diffusion of particles, first-passage front, and interface growth. PMID- 9960870 TI - Finite-length scaling of collapsing directed walks. PMID- 9960871 TI - First-passage times and survival probabilities for particles moving in a field of random correlated forces. PMID- 9960872 TI - Effective Fokker-Planck equation: Path-integral formalism. PMID- 9960874 TI - Unidimensional games, propitious environments, and maximum diversity. PMID- 9960873 TI - Two-dimensional sandpile model with stochastic slide. PMID- 9960875 TI - Growth kinetics in systems with local symmetry. PMID- 9960876 TI - Using chaos to keep period-multiplied systems in phase. PMID- 9960877 TI - Kramers problem in periodic potentials: Jump rate and jump lengths. PMID- 9960878 TI - Phase ordering in one-dimensional systems with long-range interactions. PMID- 9960879 TI - Classification theory for anequilibrium phase transitions. PMID- 9960881 TI - Schmitt trigger: A solvable model of stochastic resonance. PMID- 9960880 TI - Absolute test for theories of phase-ordering dynamics. PMID- 9960883 TI - Finite-size scaling and the crossover to mean-field critical behavior in the two dimensional Ising model with medium-ranged interactions. PMID- 9960882 TI - Excluded-volume interactions in tethered membranes. PMID- 9960884 TI - Logistic map driven by dichotomous noise. PMID- 9960886 TI - Lattice-gas analog of density-functional theory: Application to ordering transitions. PMID- 9960885 TI - Analog study of bifurcation structures in a Van der Pol oscillator with a nonlinear restoring force. PMID- 9960887 TI - Macroscopic equilibrium from microscopic irreversibility in a chaotic coupled-map lattice. PMID- 9960888 TI - Real symmetric random matrix ensembles of Hamiltonians with partial symmetry breaking. PMID- 9960890 TI - Theory of continuum random walks and application to chemotaxis. PMID- 9960889 TI - Probability of a tossed coin landing on edge. PMID- 9960891 TI - Forbidden bifurcations and parametric amplification in a Josephson-junction array. PMID- 9960892 TI - Surface-diffusion-driven kinetic growth on one-dimensional substrates. PMID- 9960893 TI - Riemann zeros and a fractal potential. PMID- 9960895 TI - Time-series expansion for reaction processes. PMID- 9960894 TI - Growth in a restricted-curvature model. PMID- 9960896 TI - Hard-particle-fluid equation of state and phase transition employing nearest neighbor correlations. PMID- 9960897 TI - Spinodal decomposition in 3-space. PMID- 9960898 TI - Statistical hydrodynamics of lattice-gas automata. PMID- 9960899 TI - Coupling between a coherent structure and fine-scale turbulence. PMID- 9960900 TI - Interaction of two liquid solitary waves in a trough resonator. PMID- 9960902 TI - Effects of disorder in pattern formation. PMID- 9960901 TI - Thermal dependence of the characteristic time of a chemical reaction. PMID- 9960903 TI - Localized states in a film-dragging experiment. PMID- 9960905 TI - Many-body electrostatic interactions in electrorheological fluids. PMID- 9960904 TI - Ordering effects in thin smectic-C* films: An x-ray-reflectivity study. PMID- 9960906 TI - Static and dynamic collective correlations of polymer brushes. PMID- 9960907 TI - Static shear stress of electrorheological fluids. PMID- 9960909 TI - Metastable wetting layers. PMID- 9960908 TI - Structure and properties of anisotropic gels and plasticized networks containing molecules with a smectic-A phase. PMID- 9960910 TI - Neutron-scattering evidence for the coupling of shear and reorientational motions in the viscoelastic liquid quinoline. PMID- 9960911 TI - Stochastic transport in heterogeneous media with multiple families of transport paths. PMID- 9960912 TI - In situ studies of colloidal aggregation induced by alternating electrical fields. PMID- 9960914 TI - Layer buckling in smectic-A liquid crystals and two-dimensional stripe phases. PMID- 9960913 TI - Conductance measurement in the micellar nematic and lamellar smectic phases of the cesium perfluoro octanoate-H2O system at high magnetic fields. PMID- 9960915 TI - Sound propagation in suspensions of solid spheres. PMID- 9960917 TI - Dynamics of order-parameter and director fluctuations in the nematic phase of a lyotropic liquid crystal. PMID- 9960916 TI - Angular correlations and the isotropic-nematic phase transition in suspensions of tobacco mosaic virus. PMID- 9960918 TI - Ordering dynamics of microscopic models with nonconserved order parameter of continuous symmetry. PMID- 9960919 TI - Dynamic light scattering from a highly swollen nonionic lamellar liquid crystal. PMID- 9960920 TI - Helfrich shape equation for axisymmetric vesicles as a first integral. PMID- 9960921 TI - Influence of surface interactions on spinodal decomposition. PMID- 9960922 TI - Instability and pattern formation in colloidal-suspension Taylor-Couette flow. PMID- 9960923 TI - Gaussian field model of fluids with an application to polymeric fluids. PMID- 9960924 TI - Simple passivation and depassivation model for pitting corrosion. PMID- 9960926 TI - Instability of the overdense plasma boundary induced by the action of a powerful photon beam. PMID- 9960925 TI - Pulses and global bifurcations in a nonlocal reaction-diffusion system. PMID- 9960927 TI - Laser-produced carbon plasma in an ambient gas. PMID- 9960928 TI - Plasma effects on atomic reaction rates in hydrogen plasmas. PMID- 9960929 TI - Effects of negative ions on nonlinear wave propagation in a magnetized rotating plasma. PMID- 9960931 TI - Multidimensional modulation of Alfven waves. PMID- 9960930 TI - Scalar model for plasma turbulence. PMID- 9960932 TI - Eigenfunction for dissipative dynamic operators and the attractor of the dissipative structure. PMID- 9960933 TI - Nonlinear conductivity and composition of partially ionized plasmas in a strong electric field. PMID- 9960934 TI - Straggling of an extended charge distribution in a partially degenerate plasma. PMID- 9960935 TI - Dielectric response function and stopping power of a two-dimensional electron gas. PMID- 9960936 TI - Nonlinear Thomson scattering of intense laser pulses from beams and plasmas. PMID- 9960938 TI - Spectral properties of two-harmonic undulator radiation. PMID- 9960937 TI - Luminosity enhancement by a self-ionized plasma in e+e- collisions. PMID- 9960939 TI - Minimizing dispersion in flexible-momentum-compaction lattices. PMID- 9960940 TI - Internal dynamics of a vector soliton in a nonlinear optical fiber. PMID- 9960941 TI - Exact N-soliton solution of the modified nonlinear Schrodinger equation. PMID- 9960942 TI - Electromagnetism in a moving chiral medium. PMID- 9960943 TI - Symmetry analysis of the Infeld-Rowlands equation. PMID- 9960945 TI - Peierls-Nabarro potential barrier for highly localized nonlinear modes. PMID- 9960944 TI - Autoresonant interaction of three nonlinear adiabatic oscillators. PMID- 9960946 TI - Grain-boundary buckling and spin-glass models of disorder in membranes. PMID- 9960947 TI - Self-consistent-field treatment of the dissociation of bound molecules in solution. PMID- 9960948 TI - Theoretical study of the effect of salt and the role of strained hydrogen bonds on the thermal stability of DNA polymers. PMID- 9960950 TI - Nonaxisymmetric vesicle shapes in a generalized bilayer-couple model and the transition between oblate and prolate axisymmetric shapes. PMID- 9960949 TI - Simulating an exploration of RNA conformation space with an appropriate parallel updating strategy. PMID- 9960952 TI - Paraxial wave-optics simulation of x-ray lasers. PMID- 9960951 TI - Theory of dendritic morphology. PMID- 9960953 TI - Wake-field accelerator in a ferromagnetic waveguide. PMID- 9960954 TI - Using nonlinear saturated feedback to control chaos: The Henon map. PMID- 9960955 TI - Phase-transition study of a one-dimensional probabilistic site-exchange cellular automaton. PMID- 9960956 TI - Refractive index of waterlike fluids. PMID- 9960957 TI - Concentration fluctuation in a polymer mixture. PMID- 9960958 TI - Relation of growth and equilibrium crystal shapes. PMID- 9960959 TI - Depolarization of light by an imperfect polarizer. PMID- 9960960 TI - Comment on "Unified expression for Fermi and Bose distributions" PMID- 9960961 TI - Melnikov function and homoclinic chaos induced by weak perturbations. PMID- 9960962 TI - Reply to "Melnikov function and homoclinic chaos induced by weak perturbations" PMID- 9960964 TI - Comment II on "Possible experiment to check the reality of a nonequilibrium temperature" PMID- 9960963 TI - Comment I on "Possible experiment to check the reality of a nonequilibrium temperature" PMID- 9960966 TI - Erratum: Bulk and interfacial properties of polar and molecular fluids PMID- 9960965 TI - Reply to "Comments on 'Possible experiment to check the reality of a nonequilibrium temperature' " PMID- 9960968 TI - Scaling properties of trough densities in sandpile models. PMID- 9960967 TI - Magnetization direction in the Heisenberg model exhibiting fractional Brownian motion. PMID- 9960969 TI - Cluster effect in initially homogeneous traffic flow. PMID- 9960970 TI - Staircase polygons and recurrent lattice walks. PMID- 9960971 TI - Renormalization-group approach to simple reaction-diffusion phenomena. PMID- 9960972 TI - S-matrix fluctuations in a model with classical diffusion and quantum localization. PMID- 9960973 TI - Internal fluctuations in a model of chemical chaos. PMID- 9960974 TI - Observation of chain stretching in Langmuir diblock copolymer monolayers. PMID- 9960975 TI - Depolarized dynamic light scattering from optically anisotropic reaction-limited aggregates. PMID- 9960976 TI - Composition waves in confined geometries. PMID- 9960978 TI - Director-charge coupling in a ferroelectric liquid crystal: Experiment. PMID- 9960977 TI - Nematic liquid crystal in a tube: The Freedericksz transition. PMID- 9960979 TI - Growth of three-dimensional silver fractal electrodeposits under damped free convection. PMID- 9960980 TI - Efficient generation of highly ionized calcium and titanium plasma columns for collisionally excited soft-x-ray lasers in a fast capillary discharge. PMID- 9960981 TI - Spatiotemporal correlation of colored noise. PMID- 9960982 TI - Activated decay rate: Finite-barrier corrections. PMID- 9960983 TI - Suppression of chaos in weakly coupled diode resonators. PMID- 9960984 TI - Jamming transition in the traffic-flow model with two-level crossings. PMID- 9960985 TI - Wave propagation in an excitable medium along a line of a velocity jump. PMID- 9960986 TI - Chaotic trapping phenomena in extended systems. PMID- 9960988 TI - Polymer chain in a random array of topological obstacles: Classification and statistics of complex loops. PMID- 9960987 TI - Rate equation of the A+A-->A reaction with probability of reaction and diffusion. PMID- 9960989 TI - First-order phase transitions, the Maxwell construction, and the momentum-space renormalization group. PMID- 9960991 TI - Nonlinear dynamics of the cellular-automaton "game of Life" PMID- 9960990 TI - Equivalent-circuit, scaling, random-walk simulation, and an experimental study of self-similar fractal electrodes and interfaces. PMID- 9960992 TI - Thermodynamic properties of a one-dimensional system of charged bosons. PMID- 9960993 TI - Sandpile models with and without an underlying spatial structure. PMID- 9960994 TI - Systematic nonperturbative approach for thermal averages in quantum many-body systems: The thermal-cluster-cumulant method. PMID- 9960995 TI - Analytic and numerical study of stochastic resonance. PMID- 9960996 TI - Hadronic intermittency and chaotic motion in rapidity space. PMID- 9960998 TI - Competition of local exponents and the fractal structure of chaotic attractors. PMID- 9960997 TI - Fractal random processes with iterated logarithmic tails: A generalization of the Shlesinger-Hughes stochastic renormalization approach. PMID- 9960999 TI - Chaotic billiards with neutral boundaries. PMID- 9961000 TI - Nested strange attractors in spatiotemporal chaotic systems. PMID- 9961001 TI - Reunion and survival of interacting walkers. PMID- 9961002 TI - Fluctuations in solidification. PMID- 9961003 TI - Finite-size scaling in the complex temperature plane applied to the three dimensional Ising model. PMID- 9961004 TI - Structure of a Langmuir-Hinshelwood reaction interface. PMID- 9961005 TI - Clustering and slow switching in globally coupled phase oscillators. PMID- 9961006 TI - Efficient determination of the nonlinear Burnett coefficients. PMID- 9961007 TI - Directed polymers with random interaction: An exactly solvable case. PMID- 9961008 TI - Nonlinear response of a periodically driven damped two-state system. PMID- 9961009 TI - Transport of a quantum particle in a dimer under the influence of two correlated dichotomic colored noises. PMID- 9961010 TI - Classical and quantum chaos of the wedge billiard. I. Classical mechanics. PMID- 9961011 TI - Classical and quantum chaos of the wedge billiard. II. Quantum mechanics and quantization rules. PMID- 9961012 TI - Diffusion on deterministic and quasirandom models of diffusion-limited aggregates. I. Isotropic diffusion. PMID- 9961013 TI - Diffusion on deterministic and quasirandom models of diffusion-limited aggregates. II. Anisotropic diffusion. PMID- 9961014 TI - Abnormal temperature-dependent variation in sound velocity for the molecular liquids benzene and hexafluorobenzene. PMID- 9961015 TI - Transitions in the kinetics and steady states of irreversible A+BC surface reaction models. PMID- 9961016 TI - Thermal conductivity of a dilute gas in a thermostated shear-flow state. PMID- 9961017 TI - Diffusion in equilibrium mixtures of ionized gases. PMID- 9961018 TI - Asymptotic analysis of primitive model electrolytes and the electrical double layer. PMID- 9961020 TI - Relative importance of convection and diffusion in binary liquid systems subject to small horizontal temperature gradients. PMID- 9961019 TI - Phase and amplitude instabilities for Benard-Marangoni convection in fluid layers with large aspect ratio. PMID- 9961021 TI - Symmetric truncations of the shallow-water equations. PMID- 9961022 TI - Collapse transition of self-avoiding walks on a square lattice in the bulk and near a linear wall: The universality classes of the theta and theta ' points. PMID- 9961023 TI - Raman scattering and water structure in nonionic amphiphile solutions. PMID- 9961024 TI - Polaron theory of positron annihilation in xenon. PMID- 9961025 TI - Dynamical theory of concentration fluctuations in polymer solutions under shear. PMID- 9961026 TI - Structures of inorganic polymers in sol-gel processes based on titanium oxide. PMID- 9961027 TI - Monte Carlo study of phase separation in critical polymer blends. PMID- 9961029 TI - Internal distances in short polyelectrolytes: A Monte Carlo study. PMID- 9961028 TI - Dynamics of near-critical polymer gels. PMID- 9961030 TI - Ferroelectric phases of dipolar hard spheres. PMID- 9961031 TI - Thermal and structural properties of the liquid-vapor interface in dipolar fluids. PMID- 9961032 TI - Thermodynamic perturbation theory: Sticky chains and square-well chains. PMID- 9961033 TI - Density fluctuations during crystallization of colloids. PMID- 9961034 TI - Simulations of shear-induced melting and ordering. PMID- 9961036 TI - Spinodal of liquid water. PMID- 9961035 TI - Freezing of adhesive hard spheres. PMID- 9961037 TI - Electric-field-induced change of the order parameter in a nematic liquid crystal. PMID- 9961038 TI - Electric-field-induced isotropic-nematic phase transition. PMID- 9961039 TI - Pattern formation in noise-reduced electrochemical deposition. PMID- 9961041 TI - Dissipation, geometry, and the stability of the dense radial morphology. PMID- 9961040 TI - Evolution of the space-charge layer during electrochemical deposition with convection. PMID- 9961042 TI - Effect of resistivity on the Rayleigh-Taylor instability in an accelerated plasma. PMID- 9961045 TI - Fokker-Planck solution for the spherical symmetry of the electron distribution function of a fully ionized plasma. PMID- 9961043 TI - Relative intensities of 3p-3s transitions in neonlike Ar IX. PMID- 9961044 TI - Numerical results on photon redistribution and Bose condensation in strongly magnetized plasmas. PMID- 9961046 TI - Enhanced Z pinch using an externally applied magnetic field to stabilize the implosion of an aluminum plasma jet onto a coaxial wire. PMID- 9961047 TI - Ion broadening of dense-plasma spectral lines including field-dependent atomic physics and the ion quadrupole interaction. PMID- 9961049 TI - Coupled-mode theory of Langmuir space-charge waves for general electron-beam and waveguide cross sections. PMID- 9961048 TI - Moment analysis of rf parallel-plate-discharge simulations using the particle-in cell with Monte Carlo collisions technique. PMID- 9961050 TI - Collective effects due to charge-fluctuation dynamics in a dusty plasma. PMID- 9961051 TI - Relativistic-configuration-interaction calculations of K alpha satellite properties for aluminum plasmas created by intense proton beams. PMID- 9961052 TI - Explicitly integrable polynomial Hamiltonians and evaluation of Lie transformations. PMID- 9961053 TI - Dynamics of the equilibrium electrons in a helical-wiggler free-electron laser with reversed guide field. PMID- 9961054 TI - Electron trajectories in a free-electron laser with a reversed axial guide field. PMID- 9961055 TI - Strong-strong simulation on the beam-beam effect in a linac-ring B factory. PMID- 9961056 TI - Darker-than-black solitons: Dark solitons with total phase shift greater than pi. PMID- 9961057 TI - Bouncing ball with a finite restitution: Chattering, locking, and chaos. PMID- 9961059 TI - Instantaneous action-at-a-distance representation of field theories. PMID- 9961058 TI - Variational approach to bistable solitary waves of the first kind in d dimensions. PMID- 9961061 TI - Interaction time of Korteweg-de Vries solitons. PMID- 9961060 TI - Solitary waves in a class of generalized Korteweg-de Vries equations. PMID- 9961062 TI - Transport properties of solitons. PMID- 9961063 TI - Wave interaction with a fractal layer. PMID- 9961064 TI - Amplification of coherent polar vibrations in biopolymers: Frohlich condensate. PMID- 9961065 TI - Neural networks with high-order connections. PMID- 9961066 TI - Fluid simulations of tokamak turbulence in quasiballooning coordinates. PMID- 9961068 TI - Repeller neural networks. PMID- 9961067 TI - Cluster method for the Ashkin-Teller model. PMID- 9961069 TI - Mean-field theory of sandpile avalanches: From the intermittent- to the continuous-flow regime. PMID- 9961070 TI - Vacancy effects on the force distribution in a two-dimensional granular pile. PMID- 9961071 TI - Determination of the dynamic critical exponent by quench kinetics simulations. PMID- 9961072 TI - Experimental determination of Ginzburg-Landau parameters for reaction-diffusion systems. PMID- 9961073 TI - Anisotropic thermal conductivity of a fluid in a system of microscopic slit pores. PMID- 9961074 TI - Phase diagrams for the blue phases of highly chiral liquid crystals. PMID- 9961075 TI - Rotational invariance and the theory of directed nematic polymers. PMID- 9961076 TI - Asymmetric cell in directional solidification. PMID- 9961077 TI - Resistive-ballooning-mode characteristics in the tokamak edge region. PMID- 9961078 TI - Direct evidence of departure from local thermodynamic equilibrium in a free burning arc-discharge plasma. PMID- 9961079 TI - Strongly localized gap solitons in diatomic lattices. PMID- 9961080 TI - Creation of nonlinear localized modes in discrete lattices. PMID- 9961082 TI - Comment on "Electric fields from steady currents and unexplained electromagnetic experiments" PMID- 9961081 TI - Nonlinear lattices and gap solitons. PMID- 9961083 TI - Reply to "Comment on 'Electric fields from steady currents and unexplained electromagnetic experiments' " PMID- 9961084 TI - Comment on "Hitting probabilities of diffusion-limited-aggregation clusters" PMID- 9961085 TI - Erratum: Consistent integral equations for two- and three-body-force models: Application to a model of silicon PMID- 9961086 TI - Saddle-point bifurcation and onset of large-scale stochasticity in 1.5-degree-of freedom Hamiltonian systems. PMID- 9961087 TI - Theory of the one-dimensional forest-fire model. PMID- 9961088 TI - Scaling functions and scaling exponents in turbulence. PMID- 9961089 TI - Exact integer algorithm for the two-dimensional +/-J Ising spin glass. PMID- 9961090 TI - Fokker-Planck approach to quantum transport statistics: Calculation of limiting probability distributions. PMID- 9961091 TI - Exact solution of "hot dimer" adsorption in one-dimensional lattices. PMID- 9961093 TI - Thermal convection in a planar nematic liquid crystal with a stabilizing magnetic field. PMID- 9961092 TI - Mechanism of the electric-field-induced vortex drift in excitable media. PMID- 9961095 TI - Core structure of a screw disclination in smectic-A liquid crystals. PMID- 9961094 TI - Monte Carlo simulation of a coupled XY model. PMID- 9961097 TI - Relativistic solitary wave in an electron-positron plasma. PMID- 9961096 TI - Wave-breaking limit to the wake-field effect in an underdense plasma. PMID- 9961098 TI - Dynamic desynchronization of a free-electron laser resonator. PMID- 9961100 TI - Fast O(N) box-counting algorithm for estimating dimensions. PMID- 9961099 TI - Stochastic electronic motion and high-efficiency free-electron lasers. PMID- 9961101 TI - Chaos in Liouville's equation. PMID- 9961102 TI - Kinetic-Ising-model description of Newtonian dynamics: A one-dimensional example. PMID- 9961103 TI - Phase equilibria and transformations in adiabatic systems. PMID- 9961104 TI - Gravity in one dimension: The critical population. PMID- 9961105 TI - Phase-ordering kinetics in nonconserved scalar systems with long-range interactions. PMID- 9961107 TI - Coordination models of random sequential adsorption in one and two dimensions. PMID- 9961106 TI - Kinetic equation for classical particles obeying an exclusion principle. PMID- 9961108 TI - Negative Poisson ratio in two-dimensional networks under tension. PMID- 9961109 TI - Statistical mechanics of kinks in 1+1 dimensions: Numerical simulations and double-Gaussian approximation. PMID- 9961110 TI - Horseshoe implications. PMID- 9961111 TI - Exact solution of a phase-separation model with conserved-order-parameter dynamics and arbitrary initial concentration. PMID- 9961112 TI - Harmonic oscillators driven by colored noise: Crossovers, resonances, and spectra. PMID- 9961113 TI - Analytic computation of the strong stochasticity threshold in Hamiltonian dynamics using Riemannian geometry. PMID- 9961114 TI - Unpredictability of symmetry breaking in a phase transition. PMID- 9961116 TI - Melting of square crystals in two dimensions. PMID- 9961115 TI - Energy diffusion in a chaotic adiabatic billiard gas. PMID- 9961117 TI - Visualizing the collective motions responsible for the alpha and beta relaxations in a model glass. PMID- 9961118 TI - Kinetic lattice-gas model of cage effects in high-density liquids and a test of mode-coupling theory of the ideal-glass transition. PMID- 9961119 TI - Onset of convection for autocatalytic reaction fronts in a vertical slab. PMID- 9961120 TI - Renormalization-group estimates of transport coefficients in the advection of a passive scalar by incompressible turbulence. PMID- 9961121 TI - Convection near threshold for Prandtl numbers near 1. PMID- 9961122 TI - Spatiotemporal structure of hydrothermal waves in Marangoni convection. PMID- 9961123 TI - Traveling-wave solutions to thin-film equations. PMID- 9961124 TI - Traveling waves in a fluid layer subjected to a horizontal temperature gradient. PMID- 9961126 TI - Taylor vortex formation in axial through-flow: Linear and weakly nonlinear analysis. PMID- 9961125 TI - Nonaxisymmetric patterns in the Saffman-Taylor problem and in three-dimensional directional solidification at low velocity. PMID- 9961127 TI - Pretransitional orientational ordering of rigid-rod polymers in shear flow. PMID- 9961128 TI - Oscillatory zoning in crystal growth: A constitutional undercooling mechanism. PMID- 9961129 TI - Monte Carlo studies of grain growth on curved surfaces. PMID- 9961130 TI - Optical- and x-ray-scattering studies of ionic ferrofluids of MnFe2O4, gamma Fe2O3, and CoFe2O4. PMID- 9961131 TI - Coarse-graining procedure to generate and analyze heterogeneous materials: Theory. PMID- 9961132 TI - Light-scattering studies in cross-linked gels: Evidence of a microphase separation. PMID- 9961133 TI - Amplitude equations for the electrohydrodynamic instability in nematic liquid crystals. PMID- 9961134 TI - Gauge theory for discotic liquid crystals. PMID- 9961135 TI - Phase transitions in solutions of variably ionizable particles. PMID- 9961136 TI - Effective microscopic model for the dynamics of spreading. PMID- 9961137 TI - Anchoring of nematic liquid crystals on mica in the presence of volatile molecules. PMID- 9961138 TI - Structural investigation of gaseous, liquid, and solid Br2 by x-ray absorption. PMID- 9961139 TI - Cross-property relations and permeability estimation in model porous media. PMID- 9961140 TI - Early-time regime for interfacial instabilities in a kinetic Ising model. PMID- 9961141 TI - Sticky hard spheres beyond the Percus-Yevick approximation. PMID- 9961142 TI - Phase diagram for amorphous solid water. PMID- 9961143 TI - Buckling instabilities of a confined colloid crystal layer. PMID- 9961144 TI - Monte Carlo study of block copolymer adsorption from dilute solutions. PMID- 9961145 TI - Structure and rheology of semidilute suspension under shear. PMID- 9961146 TI - Cyclotron-maser experiments in a periodic waveguide. PMID- 9961147 TI - Modulational instability of ion-acoustic waves in a plasma with negative ions. PMID- 9961149 TI - Positive and negative absorption by a plasma in an intense laser field. PMID- 9961148 TI - X-ray-line polarization spectroscopy in laser-produced plasmas. PMID- 9961150 TI - Center-manifold theory for low-frequency excitations in magnetized plasmas. PMID- 9961151 TI - Coherent transition radiation at submillimeter and millimeter wavelengths. PMID- 9961152 TI - Experimental determination of the Hamiltonian for synchrotron motion with rf phase modulation. PMID- 9961153 TI - Synchrobetatron-coupling effects in alternating-phase-focusing linacs. PMID- 9961155 TI - Stability of the soliton states in a nonlinear fiber coupler. PMID- 9961154 TI - Inverse-scattering approach to femtosecond solitons in monomode optical fibers. PMID- 9961156 TI - Determination of the statistical distribution of electromagnetic-field amplitudes in complex cavities. PMID- 9961157 TI - Field-factor formalism for the study of the tensorial symmetry of four-wave nonlinear optical parametric interactions in uniaxial and biaxial crystals. PMID- 9961158 TI - Stability exponents for smooth, recursive dynamical systems. PMID- 9961159 TI - Graphical and WKB analysis of nonuniform Bragg gratings. PMID- 9961160 TI - Discreteness effects on the formation and propagation of breathers in nonlinear Klein-Gordon equations. PMID- 9961162 TI - Chaotic and phase-locked breather dynamics in the damped and parametrically driven sine-Gordon equation. PMID- 9961161 TI - Dynamic phases in a spring-block system. PMID- 9961163 TI - Pattern formation in Dictyostelium via the dynamics of cooperative biological entities. PMID- 9961164 TI - Generalization in a two-layer neural network. PMID- 9961165 TI - Dynamics of globally coupled inhibitory neurons with heterogeneity. PMID- 9961166 TI - Rayleigh waves for a discrete elastic paraxial equation. PMID- 9961167 TI - Initial and boundary conditions for the lattice Boltzmann method. PMID- 9961168 TI - One-parameter family of soliton solutions with compact support in a class of generalized Korteweg-de Vries equations. PMID- 9961169 TI - Noise-induced sensitivity to the initial conditions in stochastic dynamical systems. PMID- 9961170 TI - Transport on the percolation backbone. PMID- 9961172 TI - Absorption of high-contrast 12-ps uv laser pulses by solid targets. PMID- 9961171 TI - Coexistence of hyperbolic and nonhyperbolic chaotic scattering. PMID- 9961173 TI - Nonlinear surface waves on a plasma sphere in an external electric field. PMID- 9961175 TI - Nonequilibrium lattice models: A case with effective Hamiltonian in d dimensions. PMID- 9961174 TI - Erratum: Dendritic sidebranching with periodic localized perturbations: Directional solidification of pivalic acid-coumarin 152 mixtures PMID- 9961177 TI - Parametrizations for Daubechies wavelets. PMID- 9961176 TI - Degenerate routes to chaos. PMID- 9961179 TI - Coexistence of morphologies in diffusive patterning. PMID- 9961178 TI - Quantum versus classical control of tunneling. PMID- 9961180 TI - Prototypes of attractors in four dimensions. PMID- 9961181 TI - Phase transitions in two-dimensional traffic-flow models. PMID- 9961182 TI - Generic behavior in linear systems with multiplicative noise. PMID- 9961184 TI - Arbitrary-width confined states of traveling-wave convection: Pinning, locking, drift, and stability. PMID- 9961183 TI - Exact renormalization-group approach to the generating function of the Vicsek fractal. PMID- 9961186 TI - Two-stage collapse of a polymer chain in two dimensions. PMID- 9961185 TI - Chaotic Turing-Hopf mixed mode. PMID- 9961187 TI - Two-dimensional Landau-de Gennes dynamical model for the unwinding transition of a cholesteric liquid crystal. PMID- 9961188 TI - Vesicle adsorption on a plane: Scaling regimes and crossover phenomena. PMID- 9961189 TI - Theory of diffusion-limited growth. PMID- 9961191 TI - Bounded cascade models as nonstationary multifractals. PMID- 9961190 TI - Bit-level correlations in some pseudorandom number generators. PMID- 9961193 TI - Two-dimensional quantum spin Hamiltonians: Spectral properties. PMID- 9961192 TI - Quantum modifications of classical diffusion in coordinate space for chaotic systems. PMID- 9961194 TI - Critical dimensionalities of phase transitions on fractals. PMID- 9961196 TI - Temperature as a bifurcation parameter in nonlinear electronic circuits. PMID- 9961195 TI - Self-organized criticality in computer models of settling powders. PMID- 9961197 TI - Some properties of invariant random-matrix ensembles and their connection to ergodic and nonergodic Hamiltonian systems. PMID- 9961198 TI - Kinetic super-roughening and anomalous dynamic scaling in nonequilibrium growth models. PMID- 9961199 TI - Maximum-likelihood estimation of the entropy of an attractor. PMID- 9961201 TI - Two-temperature kinetic Ising model in one dimension: Steady-state correlations in terms of energy and energy flux. PMID- 9961200 TI - Statistical properties of chaotic scattering with one open channel. PMID- 9961203 TI - Loci of limit cycles. PMID- 9961202 TI - Quantum dynamics as a stochastic process. AB - The quantum Liouville equation is solved in the Wigner representation using generalized Monte Carlo techniques. For small increments of time, the solution is represented as a sequential classical evolution in phase space followed by a quantum "jump" distribution in momentum space, with the latter simulated via a stochastic method. Extending the work initiated by John and Remler [Ann Phys. (N.Y.) 180, 152 (1987)] the technique is developed and validated for higher dimensions. Also, an alternative algorithm is developed and applied to study motion of a quantum system in an anharmonic quartic potential well, with significantly improved results. PMID- 9961204 TI - Secondary instabilities in the stabilized Kuramoto-Sivashinsky equation. PMID- 9961205 TI - Pattern-formation characteristics of interacting kinematic waves. PMID- 9961206 TI - Statistical closure and the logistic map. PMID- 9961207 TI - Multiscaling behavior in the crossover between surface and bulk critical exponents for percolation in two dimensions. PMID- 9961208 TI - Delay-induced instabilities in nonlinear feedback systems. PMID- 9961209 TI - Stabilization of quasiperiodic orbits for line-coupled diode resonator systems. PMID- 9961210 TI - Weak non-self-averaging behavior for diffusion in a trapping environment. PMID- 9961211 TI - Quasilattice of fixed points of the fivefold stochastic web map. PMID- 9961213 TI - Escape rates in bistable systems induced by quasimonochromatic noise. PMID- 9961212 TI - Pinning in phase-separating systems. PMID- 9961214 TI - Long-range correlations in diffusive systems away from equilibrium. PMID- 9961215 TI - Tunneling and the onset of chaos in a driven bistable system. PMID- 9961216 TI - Density waves in the flows of granular media. PMID- 9961217 TI - Anisotropic polydomain structure in a driven lattice gas with repulsive interaction. PMID- 9961218 TI - Adsorption of line segments on a square lattice. PMID- 9961219 TI - Synchronization of chaos using proportional feedback. PMID- 9961220 TI - Suppression of chaos by nonresonant parametric perturbations. PMID- 9961221 TI - Transition from Poissonian to Gaussian-orthogonal-ensemble level statistics in a modified Artin's billiard. PMID- 9961222 TI - Fluctuations in radioactive decays. I. Nonequilibrium effects and noise. PMID- 9961223 TI - Fluctuations in radioactive decays. II. Experimental results. PMID- 9961225 TI - Transverse-current autocorrelation-function calculations of the shear viscosity for molecular liquids. PMID- 9961224 TI - Relaxation dynamics of hot protons in a thermal bath of atomic hydrogen. PMID- 9961226 TI - Monte Carlo simulation of the Boltzmann equation for steady Fourier flow. PMID- 9961227 TI - Self-consistent solution for the generalized hydrodynamics model of suspension dynamics: Comparison of theory with rheological and optical measurements. PMID- 9961228 TI - Exploring the influence of three-body classical dispersion forces on phase equilibria of simple fluids: An integral-equation approach. PMID- 9961229 TI - Mathematical model for laser ablation to generate nanoscale and submicrometer size particles. PMID- 9961230 TI - Non-Newtonian effects on immiscible viscous fingering in a radial Hele-Shaw cell. PMID- 9961231 TI - Phonons in liquids, Onsager's reciprocal relations, and the heats of transport. PMID- 9961232 TI - Stability of a planar flame front in the slow-combustion regime. PMID- 9961233 TI - Quantitative experimental study of the free decay of quasi-two-dimensional turbulence. PMID- 9961234 TI - Measurement of a short-wavelength instability in Taylor vortex flow. PMID- 9961235 TI - Robustness of vortex streets. PMID- 9961236 TI - Mean-field theories of random advection. PMID- 9961238 TI - Monte Carlo study of interfacial properties in an amphiphilic system. PMID- 9961237 TI - Spatially uniform traveling cellular patterns at a driven interface. PMID- 9961239 TI - Molecular theory of elastic constants of liquid crystals. II. Application to the biaxial nematic phase. PMID- 9961240 TI - Pair-correlation function in two-dimensional lattice gases. PMID- 9961241 TI - Anisotropy in Langmuir monolayers supported by flowing water. PMID- 9961243 TI - Mass diffusion of diatomic fluids in random micropore spaces using equilibrium molecular dynamics. PMID- 9961242 TI - Phase separation in binary mixtures confined in a strip geometry. PMID- 9961244 TI - Director fluctuations and anisotropic reorientation of a liquid crystal: A deuterium NMR study. PMID- 9961245 TI - Thermal conductivity of the nematic liquid crystal 4-n-pentyl-4'-cyanobiphenyl. PMID- 9961246 TI - Mesoscopic physics of swollen polymer networks: Statics and dynamics. PMID- 9961247 TI - Structure and shape of nematic liquid-crystal microdroplets. PMID- 9961248 TI - Screening effect and phase transitions in solutions of rodlike dipoles. PMID- 9961249 TI - Self-consistent-field calculation of the structure of the static properties of the solid-fluid interface: The monomer systems. PMID- 9961250 TI - Computation of the water density distribution at the ice-water interface using the potentials-of-mean-force expansion. PMID- 9961251 TI - Dynamic simulations of shear-flow-induced chirality and twisted-texture transitions of a liquid-crystalline polymer. PMID- 9961253 TI - Critical-noise measurement near Freedericksz transitions in nematic liquid crytals. PMID- 9961252 TI - Monte Carlo study of the effect of an applied field on the molecular organization of polymer-dispersed liquid-crystal droplets. PMID- 9961254 TI - Anchoring properties of lyotropic liquid crystals near the nematic-isotropic transition. PMID- 9961255 TI - Test of the bounds on the crossover exponent for polymer adsorption on fractals. PMID- 9961256 TI - Nucleation and growth with periodic modulation: Asymptotic versus exact results. PMID- 9961258 TI - Production of large O-containing neutral hydrocarbon species by a CH4-O2 microwave discharge. PMID- 9961257 TI - Morphology of Ge:Al thin films: Experiments and model. PMID- 9961259 TI - Electron-ion relaxation in a plasma interacting with an intense laser field. PMID- 9961260 TI - Variational approach to approximate propagation of Gaussian pulses in a Langmuir plasma. PMID- 9961261 TI - Short-pulse terahertz radiation from high-intensity-laser-produced plasmas. PMID- 9961263 TI - Ion- and electron-temperature fluctuations excited by resistive instabilities in a self-consistently stationary inhomogeneous plasma. PMID- 9961262 TI - Langevin approach to collisional bremsstrahlung in a magnetic field. PMID- 9961264 TI - Negative-energy perturbations in general and in arbitrary one-dimensional Vlasov Maxwell equilibria. PMID- 9961265 TI - Collision operators for partially linearized particle simulation codes. PMID- 9961266 TI - Construction of symplectic maps for nonlinear motion of particles in accelerators. PMID- 9961267 TI - Net electron acceleration by a strong laser field and a rf wave. PMID- 9961268 TI - Three-dimensional theory of an ion-ripple laser. PMID- 9961269 TI - From the beam-envelope matrix to synchrotron-radiation integrals. PMID- 9961270 TI - Electron trajectories in a helical free-electron laser with an axial guide field. PMID- 9961271 TI - Coherent transition radiation in the far-infrared region. PMID- 9961272 TI - Trapped electromagnetic modes in a waveguide with a small discontinuity. PMID- 9961273 TI - Spectral behavior of high-power Compton free-electron lasers. I. Broadening and asymptotic equilibrium. PMID- 9961274 TI - Spectral behavior of high-power Compton free-electron lasers. II. Effect of filtering and tapering on sideband generation. PMID- 9961276 TI - Integrability and localized excitations in nonlinear discrete systems. PMID- 9961275 TI - Generation of envelope and hole solitons in an experimental transmission line. PMID- 9961277 TI - Structural information in the local electric field of dissolved B-DNA. PMID- 9961279 TI - Near-neighbor effects in cooperative modified self-consistent phonon approximation melting in DNA. PMID- 9961278 TI - Knotting and supercoiling in circular DNA: A model incorporating the effect of added salt. PMID- 9961280 TI - Winding-number effect in path-integral simulations. PMID- 9961281 TI - Noninterferometric reconstruction of optical-field correlations. PMID- 9961283 TI - Roughening interfaces in the dynamics of perturbations of spatiotemporal chaos. PMID- 9961282 TI - Continuous approximation of a random walk. PMID- 9961284 TI - Effects of the relative scales between particles added and toppled each time on the distribution of avalanche size in Abelian sandpiles. PMID- 9961285 TI - Derivation of the modified diffusion equations in a gas mixture. PMID- 9961286 TI - Computer-simulation study of the interface between graphite and hydrocarbon mixtures: Preferential adsorption and dynamics. PMID- 9961287 TI - Jumping droplets. PMID- 9961288 TI - Nematic-cholesteric mixture in a magnetic field: A change in the critical behavior. PMID- 9961289 TI - Multidiffusion in critical dynamics of strings and membranes. PMID- 9961290 TI - Calculation of a surface-induced polar effect in nematic liquid crystals. PMID- 9961292 TI - Stationary convection in a plasma of inhomogeneous density. PMID- 9961291 TI - Effects of nonequilibrium plasmas on atomic reaction rates. PMID- 9961293 TI - Erratum: Phenomenological approach to the problem of the K13 surfacelike elastic term in the free energy of a nematic liquid crystal PMID- 9961295 TI - Phase representation and its application in the analytical treatment of the theoretical sandpile. PMID- 9961294 TI - Periodic orbit analysis of billiard level dynamics. PMID- 9961296 TI - Probability distribution for a multifractal field. PMID- 9961297 TI - Signatures of chaos in quantum billiards: Microwave experiments. PMID- 9961298 TI - Static parametric fluctuations give nonstatistical behavior in uncoupled chaotic systems. PMID- 9961299 TI - Lorentz transformations in bifurcating systems. PMID- 9961300 TI - Nonequilibrium density profiles of deposition-evaporation stochastic systems. PMID- 9961301 TI - Growth laws for phase ordering. PMID- 9961302 TI - Thermally sustained structure in convectively unstable systems. PMID- 9961303 TI - Dynamics of dislocations in hexagonal patterns. PMID- 9961304 TI - Surface-pattern evolution in a swelling gel under a geometrical constraint: Direct observation of fold structure and its coarsening dynamics. PMID- 9961305 TI - Conductance noise in electrodeposition. PMID- 9961306 TI - Free-electron-laser model without the slowly-varying-envelope approximation. PMID- 9961307 TI - Instability of a crack in a heated strip. PMID- 9961308 TI - Fractal-to-Euclidean crossover of the thermodynamic properties of the Ising model. PMID- 9961309 TI - Safe, explosive, and dangerous bifurcations in dissipative dynamical systems. PMID- 9961310 TI - Percolation of a simulated metallic film on a porous substrate: The copper polyimide interface. PMID- 9961311 TI - Nonequilibrium temperature versus local-equilibrium temperature. PMID- 9961312 TI - Reaction efficiency of diffusion-controlled processes on finite, planar arrays. PMID- 9961313 TI - Kinetics of restricted solid-on-solid models of film growth. PMID- 9961314 TI - Universality class for extinction-survival phase transition in one dimension. PMID- 9961316 TI - Virial expansions for quantum plasmas: Diagrammatic resummations. PMID- 9961315 TI - Border-collision bifurcations: An explanation for observed bifurcation phenomena. PMID- 9961317 TI - Converting transient chaos into sustained chaos by feedback control. PMID- 9961318 TI - Spatiotemporally periodic states, periodic windows, and intermittency in coupled map lattices. PMID- 9961320 TI - Helimagnetism in XY models: Domain walls, frustrations, fractional vortices, and phase transitions. PMID- 9961319 TI - Scale invariance in turbulent front propagation. PMID- 9961321 TI - Distribution of escape times in a driven stochastic model. PMID- 9961322 TI - Characterization of on-off intermittency. PMID- 9961323 TI - Seismicity and self-organized criticality. PMID- 9961324 TI - Sandpiles and river networks: Extended systems with nonlocal interactions. PMID- 9961325 TI - Orbits in one-dimensional finite linear cellular automata. PMID- 9961326 TI - Scaling of fluctuations in one-dimensional interface and hopping models. PMID- 9961327 TI - Scaling properties of diffusion-limited aggregation, the percolation hull, and invasion percolation. PMID- 9961328 TI - Supernarrow spectral peaks and high-frequency stochastic resonance in systems with coexisting periodic attractors. PMID- 9961330 TI - Using neural networks for controlling chaos. PMID- 9961329 TI - Optimized planar dividing surfaces for asymmetric activated-rate processes. PMID- 9961332 TI - Avalanches and correlations in driven interface depinning. PMID- 9961331 TI - Theory of self-organized interface depinning. PMID- 9961333 TI - Dynamics of the condensation of a saturated vapor into droplets. PMID- 9961335 TI - Difference-quotient turbulence model: A generalization of Prandtl's mixing-length theory. PMID- 9961334 TI - Molecular-dynamics study of dynamical properties of dense soft-sphere fluids: The role of short-range repulsion of the intermolecular potential. PMID- 9961336 TI - Constructing the Lagrangian in the Eulerian coordinate for relativistic hydrodynamics. PMID- 9961337 TI - Model equations for two-dimensional quasipatterns. PMID- 9961338 TI - Passive scalar fluctuations with and without a mean gradient: A numerical study. PMID- 9961339 TI - Formation of singularities on the free surface of an ideal fluid. PMID- 9961340 TI - Absolute and convective instabilities and noise-sustained structures in the Couette-Taylor system with an axial flow. PMID- 9961342 TI - Chaos in the model of repetitive phase transitions with hysteresis: Application to the self-sustained potential oscillations of lipid-bilayer membranes induced by gel-liquid-crystal phase transitions. PMID- 9961341 TI - Experimental evaluation of the intrinsic noise in the Couette-Taylor system with an axial flow. PMID- 9961343 TI - Polymer model with annealed dilution on the square lattice: A transfer-matrix study. PMID- 9961344 TI - Periodic stripe domains and hybrid-alignment regime in nematic liquid crystals: Threshold analysis. PMID- 9961345 TI - Path-integral variational methods for flow through porous media. PMID- 9961346 TI - Theory of reorientational transitions in ferrielectric liquid crystals. PMID- 9961347 TI - Fluctuations of a defect line of molecular orientation in a monolayer. PMID- 9961348 TI - Statistical mechanics of polyampholytes. PMID- 9961349 TI - Anisotropic renormalization of thermodynamic quantities above the nematic-smectic A phase transition. PMID- 9961350 TI - Experimental study of the approach to a double critical point in the poly(styrene) plus acetone system: Test of fluctuation-isomorphism theory. PMID- 9961351 TI - Hydrodynamic modes of viscoelastic polymer films. PMID- 9961352 TI - Roughness effect on the frictional force in boundary lubrication. PMID- 9961353 TI - Dynamic critical phenomena in water-butoxyethanol mixtures studied by viscosity and light-scattering measurements. PMID- 9961354 TI - Calculating the surface potential of unionized monolayers. PMID- 9961356 TI - Thermal-fluctuation approach to Freedericksz transitions in nematic liquid crystals. PMID- 9961357 TI - Phase diagram of a model anticlustering binary mixture in two dimensions: A semi grand-canonical Monte Carlo study. PMID- 9961355 TI - Monte Carlo simulation of the unwinding of cholesteric twist. PMID- 9961358 TI - Scattering from internal interfaces in microemulsion and sponge phases. PMID- 9961359 TI - Theory of orientational elasticity. PMID- 9961360 TI - Crossover exponent for polymer adsorption in two dimensions. PMID- 9961361 TI - Growth shape of 3He needle crystals. PMID- 9961362 TI - Self-affine fractal electrodeposited gold surfaces: Characterization by scanning tunneling microscopy. PMID- 9961363 TI - Spectroscopic diagnostics in a colliding-blast-wave experiment. PMID- 9961364 TI - Implosion of D2 temperature-controlled cryogenic foam targets with plastic ablators. PMID- 9961366 TI - Stationary population inversion of hydrogen in an arc-heated magnetically trapped expanding hydrogen-helium plasma jet. PMID- 9961365 TI - Ballooning-mode stability of shaped high- beta tokamaks. PMID- 9961367 TI - Ionization and stopping of heavy ions in dense laser-ablated plasmas. PMID- 9961369 TI - Coupled Langmuir and nonlinear ion-acoustic waves in collisional plasmas. PMID- 9961368 TI - Bremsstrahlung and nonlinear currents in a dense plasma exposed to an intense laser field. PMID- 9961371 TI - Amplification of extreme-ultraviolet radiation in a gas-liner pinch plasma. PMID- 9961370 TI - Experimental Stark widths and shifts and transition probabilities of several Xe II lines. PMID- 9961372 TI - Effects of frequency mismatch and wave dispersion on a self-consistent Hamiltonian model for an arbitrary-amplitude cyclotron-resonance laser accelerator. PMID- 9961373 TI - Transverse particle motion in radio-frequency linear accelerators. PMID- 9961374 TI - Hamiltonian analysis of the transition to the high-gain regime in a Compton free electron-laser amplifier. PMID- 9961376 TI - Conserved energy approximation to wave scattering by a nonlinear interface. PMID- 9961375 TI - Effects of the synchro-betatron coupling induced by dipole-field modulation. PMID- 9961377 TI - Studies of columns of beads under external vibrations. PMID- 9961378 TI - Model for the propagation of sound in granular materials. PMID- 9961379 TI - Perturbation-induced dynamics of dark solitons. PMID- 9961380 TI - Spectral properties of stochastic electromagnetic fields with spherical symmetry. PMID- 9961381 TI - Bound solitons in the ac-driven, damped nonlinear Schrodinger equation. PMID- 9961382 TI - Continuum model for the spatiotemporal growth of bacterial colonies. PMID- 9961384 TI - Storage capacity of neural networks storing spatially correlated patterns. PMID- 9961383 TI - Mosaic organization of DNA nucleotides. AB - Long-range power-law correlations have been reported recently for DNA sequences containing noncoding regions. We address the question of whether such correlations may be a trivial consequence of the known mosaic structure ("patchiness") of DNA. We analyze two classes of controls consisting of patchy nucleotide sequences generated by different algorithms--one without and one with long-range power-law correlations. Although both types of sequences are highly heterogenous, they are quantitatively distinguishable by an alternative fluctuation analysis method that differentiates local patchiness from long-range correlations. Application of this analysis to selected DNA sequences demonstrates that patchiness is not sufficient to account for long-range correlation properties. PMID- 9961385 TI - Recursive definition of global cellular-automata mappings. PMID- 9961386 TI - Efficient Green's-function approach to finding the currents in a random resistor network. PMID- 9961387 TI - Comparison of flux-correcting and spline algorithms for solving (3+1)-dimensional relativistic hydrodynamics. PMID- 9961388 TI - Stochastic resonance in a chemical reaction. PMID- 9961389 TI - Determination of the order-parameter critical exponent of an irreversible dimer monomer surface-reaction model. PMID- 9961391 TI - Partition function of the rigid rotator at high temperatures using the Hubbard Statanovich transformation. PMID- 9961390 TI - Self-affine fractals and the limit H-->0. PMID- 9961392 TI - Universality of period doubling in coupled maps. PMID- 9961393 TI - Class of cellular automata for reaction-diffusion systems. PMID- 9961395 TI - Suppression of Hamiltonian chaos by Coulomb repulsion in finite-amplitude electroconvection. PMID- 9961394 TI - Improved calculation of the third virial coefficient of a free anyon gas. PMID- 9961396 TI - Dissipative Boussinesq system of equations in the Benard-Marangoni phenomenon. PMID- 9961397 TI - Anisotropies in diffusion-limited aggregates on square-lattice diffusion-limited aggregates. PMID- 9961398 TI - Depolarization of multiply scattered waves by spherical diffusers: Influence of the size parameter. PMID- 9961399 TI - Semiclassical analysis of traversal time through Kac's solution of the telegrapher's equation. PMID- 9961400 TI - Correlated-data-driven dynamics in a neural network. PMID- 9961401 TI - Comment on "Abelian sandpile model" PMID- 9961403 TI - Suppression of chaos, quantum resonance, and statistics of a nonintegrable system. PMID- 9961402 TI - Dynamics of rough surfaces with an arbitrary topology. PMID- 9961404 TI - Enhancing synchronism of chaotic systems. PMID- 9961405 TI - Random-adding determination of percolation thresholds in interacting systems. PMID- 9961406 TI - Products of random matrices for disordered systems. PMID- 9961408 TI - Hidden symmetry, exact relations, and a small parameter in the Kardar-Parisi Zhang problem with strong coupling. PMID- 9961407 TI - Fractal random walks from a variational formalism for Tsallis entropies. PMID- 9961409 TI - Long-time behavior of the semiclassical baker's map. PMID- 9961410 TI - First-passage time and the fluctuation of the quenched disorder in biased media. PMID- 9961411 TI - Controlling unstable periodic orbits by a delayed continuous feedback. PMID- 9961412 TI - Vortical scales for two- and three-dimensional turbulence. PMID- 9961413 TI - Optical determination of the saddle-splay elastic constant K24 in nematic liquid crystals. PMID- 9961415 TI - Doubly anchored nematic polymer brushes: Shear, field effects, and quasipiezoelectricity. PMID- 9961416 TI - Anchoring transition in a nematic liquid crystal composed of centrosymmetric molecules. PMID- 9961414 TI - Application of the modified hypernetted-chain integral equation to supercooled and expanded liquid structures. PMID- 9961418 TI - Amplification of electromagnetic waves in dusty nonstationary plasmas. PMID- 9961417 TI - Growth instabilities in mechanical breakdown. PMID- 9961420 TI - Feynman path-integral representation for scalar-wave propagation. PMID- 9961419 TI - Stabilizing a breather in the damped nonlinear Schrodinger equation driven by two frequencies. PMID- 9961421 TI - Analyzing long-range correlations in finite sequences. PMID- 9961422 TI - Structures in classical phase space and quantum chaotic dynamics. PMID- 9961423 TI - Predicting physical variables in time-delay embedding. PMID- 9961425 TI - Effective multifractal spectrum of a random walk. PMID- 9961424 TI - Chaotic dynamics in the rf superconducting quantum-interference-device magnetometer: A coupled quantum-classical system. PMID- 9961426 TI - Mutually destructive fluctuations in globally coupled arrays. PMID- 9961427 TI - Exact analytic formula for the correlation time of a single-domain ferromagnetic particle. PMID- 9961428 TI - Blocking of metastable phase formation by an external field. PMID- 9961430 TI - Multiple phase coexistence in finite systems. PMID- 9961429 TI - Analysis of dynamics in a parametrically damped pendulum. PMID- 9961431 TI - Mapping between a self-attracting self-avoiding surface and a percolation hull in three dimensions. PMID- 9961432 TI - Second-law irreversibility and phase-space dimensionality loss from time reversible nonequilibrium steady-state Lyapunov spectra. PMID- 9961433 TI - Order-parameter flow in the fully connected Hopfield model near saturation. PMID- 9961434 TI - Noise-enhanced heterodyning in bistable systems. PMID- 9961435 TI - Interacting domain walls and the five-vertex model. PMID- 9961436 TI - State-space reconstruction using averaged scalar products of the dynamical system flow vectors. PMID- 9961437 TI - Correspondence in quasiperiodic and chaotic maps: Quantization via the von Neumann equation. PMID- 9961438 TI - Self-organized criticality involving vector fields and random driving. PMID- 9961439 TI - Modal feedback control on chaotic trajectories. PMID- 9961440 TI - Quantum Monte Carlo study of tunneling diffusion in a dissipative multistate system. PMID- 9961442 TI - Parametric ordering of complex systems. PMID- 9961441 TI - Dynamics of complex interfaces. PMID- 9961443 TI - Kac model from a dynamical system's point of view. PMID- 9961445 TI - Calculation of thermal-diffusion coefficients from plane-wave fluctuations in the heat energy density. PMID- 9961444 TI - Monte Carlo study of a kinetic lattice model with random diffusion of disorder. PMID- 9961447 TI - Two-dimensional nonlinear dynamics of four driven vortices. PMID- 9961446 TI - Exact results for phase separation in an asymmetric model of an interacting binary mixture. PMID- 9961448 TI - Energy decay in Burgers turbulence and interface growth: The problem of random initial conditions. II. PMID- 9961450 TI - Dispersion-induced patterns. PMID- 9961449 TI - Fluctuation-induced first-order transition and dynamic scaling in Rayleigh-Benard convection. PMID- 9961451 TI - Higher-order nonlinear evolution equation for interfacial waves in a two-layer fluid system. PMID- 9961452 TI - Pattern formation in laser-induced melting. PMID- 9961453 TI - Dependence of drag on a Galilean invariance-breaking parameter in lattice Boltzmann flow simulations. PMID- 9961454 TI - Nonuniform broken-parity waves and the Eckhaus instability. PMID- 9961455 TI - Chaotic instabilities in smectic-C liquid crystals. PMID- 9961456 TI - Phase conjugation in critical microemulsions. PMID- 9961457 TI - Surface-layer phase transitions in nematic liquid crystals. PMID- 9961459 TI - Perturbation theory applied to the freezing of classical systems. PMID- 9961458 TI - Critical temperature of Ising films with cubic lattices. PMID- 9961460 TI - Dynamics of heterogeneous polymer networks. PMID- 9961461 TI - Phase equilibria of Lennard-Jones dipolar plus quadrupolar fluids by Gibbs ensemble Monte Carlo simulation. PMID- 9961462 TI - Density distribution of a fluid through a microporous solid: Monte Carlo simulation. PMID- 9961464 TI - Influence of surface interaction and chain stiffness on polymer-induced entropic forces and the dimensions of confined polymers. PMID- 9961463 TI - Light-scattering study of the liquid-glass transition in propylene carbonate. PMID- 9961465 TI - Kinetics of phase separation in two-dimensional systems with competing interactions. PMID- 9961466 TI - Phase-field model of eutectic growth. PMID- 9961467 TI - Nonlinear coupling in the crossing-angle beam-beam interaction. PMID- 9961468 TI - Kinetic theory of runaway air breakdown. PMID- 9961469 TI - Four ways to determine the electron density in low-temperature plasmas. PMID- 9961470 TI - Observation of temporal plasma-wave echoes in an ion-wave regime. PMID- 9961471 TI - Spectroscopic measurements of electron density and temperature in polyacetal capillary-discharge plasmas. PMID- 9961472 TI - Chaos in reversed-field-pinch plasma simulation and experiment. PMID- 9961473 TI - Coupling of space-dependent electron dynamics and vibrational kinetics in radio frequency discharges in nitrogen. PMID- 9961474 TI - Raman-ripple lasers. PMID- 9961476 TI - Simulation of the beam halo from the beam-beam interaction. PMID- 9961475 TI - Laser thermonuclear fusion with force confinement of hot plasma. PMID- 9961477 TI - Longitudinal bunched-beam instabilites going nonlinear: Emittance growth, beam splitting, and turbulence. PMID- 9961478 TI - Determination of the linear coupling resonance strength using two-dimensional invariant tori. PMID- 9961479 TI - Wave propagation in granular assemblies. PMID- 9961480 TI - Multiple-scattering formalism for general discrete random composites. PMID- 9961482 TI - Birefringence by a smoothly inhomogeneous locally isotropic medium. PMID- 9961481 TI - Structural stability and selection of propagating fronts in semilinear parabolic partial differential equations. PMID- 9961483 TI - Direct perturbation theory for dark solitons. PMID- 9961484 TI - Theory of DNA electrophoresis in physical gels and entangled polymer solutions. PMID- 9961485 TI - Scaling behavior of some molecular shape descriptors of polymer chains and protein backbones. PMID- 9961487 TI - Efficient large-scale simulations of a uniformly driven system. PMID- 9961486 TI - Supercoiling transitions of closed DNA. PMID- 9961489 TI - Field-induced phase transitions of simple dipolar fluids. PMID- 9961488 TI - Series expansions without diagrams. PMID- 9961490 TI - Solvable Ising model on Sierpinski carpets: The partition function. PMID- 9961491 TI - Berry's phase in a one-dimensional quantum many-body system. PMID- 9961493 TI - Turbulence with an infinite number of conservation laws. PMID- 9961492 TI - Randomly driven Korteweg-de Vries-Burgers equation. PMID- 9961495 TI - Kinetic phase transition in polymerization. PMID- 9961494 TI - Influence of the liquid-crystal splay-bend surface elastic constant on director fluctuations and light scattering. PMID- 9961496 TI - Transport and sound waves in plasmas with light and heavy ions. PMID- 9961497 TI - Theoretical study of longitudinal beam splitting and related phenomena. PMID- 9961498 TI - Comment on "Use of the McQuarrie equation for the computation of shear viscosity via equilibrium molecular dynamics" PMID- 9961499 TI - Comment on "Low-frequency Raman-scattering study of the liquid-glass transition in aqueous lithium chloride solutions" PMID- 9961501 TI - Erratum: Stochastic averaging of the time-evolution operator for quantum systems driven by Ornstein-Uhlenbeck colored noise: A nonperturbative cluster cumulant method PMID- 9961500 TI - Reply to "Comment on 'Low-frequency Raman-scattering study of the liquid-glass transition in aqueous lithium chloride solutions' " PMID- 9961502 TI - Fractals without anomalous diffusion. PMID- 9961503 TI - Nonuniversal diffusion-limited aggregation and exact fractal dimensions. PMID- 9961504 TI - Stochastic resonance in a tunnel diode. PMID- 9961506 TI - Nonlocal vorticity cascade in two dimensions. PMID- 9961505 TI - Density waves of granular flow in a pipe using lattice-gas automata. PMID- 9961507 TI - Numerical study of oscillatory crack propagation through a two-dimensional crystal. PMID- 9961508 TI - Self-affine fractal crystal from an NH4Cl solution. PMID- 9961509 TI - Cylindrical phases of isotropic diblock copolymers as giant wormlike nematic liquid crystals: Frank elasticity and Freedericksz transitions. PMID- 9961510 TI - Experimental observation of transmission- and self-emission-type radiation transport in x-ray-produced plasmas. PMID- 9961511 TI - Large amplitude plasma wave excitation by means of sequences of short laser pulses. PMID- 9961512 TI - Response functions improving performance in analog attractor neural networks. PMID- 9961513 TI - Bond-updating mechanism in cluster Monte Carlo calculations. PMID- 9961515 TI - From dynamics to statistical mechanics in the Henon-Heiles model: Dynamics. PMID- 9961514 TI - Critical scaling behavior in the activated-barrier-crossing problem. PMID- 9961516 TI - Low-dimensional turnover theory of thermal activation. PMID- 9961518 TI - High-temperature series expansions for Ising-like systems on fractals. PMID- 9961517 TI - Kardar-Parisi-Zhang model and anomalous elasticity of two- and three-dimensional smectic-A liquid crystals. PMID- 9961520 TI - Dynamic instability in crack propagation. PMID- 9961519 TI - Correlation functions in disordered systems. PMID- 9961521 TI - Stability and kinetics of step motion on crystal surfaces. PMID- 9961522 TI - Wavelength-doubling bifurcations in one-dimensional coupled logistic maps. PMID- 9961524 TI - Spectral properties of a time-periodic Fokker-Planck equation. PMID- 9961523 TI - Magnetic-field dependence of chemical reaction rates at high temperatures. PMID- 9961525 TI - Mean field model for spatially extended systems in the presence of multiplicative noise. PMID- 9961526 TI - Spectral 1/f noise derived from extremized physical information. PMID- 9961527 TI - Observing chaos: Deducing and tracking the state of a chaotic system from limited observation. PMID- 9961529 TI - Threshold effects on synchronization of pulse-coupled oscillators. PMID- 9961528 TI - Correlations and dynamics in ensembles of maps: Simple models. PMID- 9961530 TI - Fractal and topological properties of directed fractures. PMID- 9961531 TI - Closed-form solutions and free energy of hard-spin mean-field theory of a fully frustrated system. PMID- 9961532 TI - Inverse avalanches in the Abelian sandpile model. PMID- 9961534 TI - Possibilities and limitations of Gaussian-closure approximations for phase ordering dynamics. PMID- 9961533 TI - Wick's theorem at nonzero temperatures. PMID- 9961535 TI - Domain growth in a one-dimensional diffusive lattice gas with short-range attraction. PMID- 9961536 TI - Finite-range-scaling analysis of metastability in an Ising model with long-range interactions. PMID- 9961537 TI - Non-Abelian symmetries of stochastic processes: Derivation of correlation functions for random-vertex models and disordered-interacting-particle systems. PMID- 9961538 TI - Series expansion method based on the droplet description of ferromagnetic and fully frustrated q-state Potts models. PMID- 9961539 TI - Dynamics of a globally coupled laser model. PMID- 9961540 TI - Time-series analysis of transient chaos. PMID- 9961541 TI - Extended mean-field study of a stochastic cellular automaton. PMID- 9961542 TI - Colored noise in spatially extended systems. PMID- 9961543 TI - Intermittency inhibited by transport: An exactly solvable model. PMID- 9961544 TI - Stochastic dynamics of diffusive deposition-evaporation processes in the presence of defects. PMID- 9961546 TI - Intermittent dynamics and self-organized depinning in propagating fronts. PMID- 9961545 TI - Statistics of self-avoiding walks on randomly diluted lattices. PMID- 9961548 TI - Weighted-density-functional theory of solvation forces in liquids. PMID- 9961547 TI - Application of the generalized Chapman-Enskog method to the transport-coefficient calculation in a reacting gas mixture. PMID- 9961549 TI - Potential effects on atomic motions in liquid alkali metals. PMID- 9961550 TI - Role of hydrogen-bond cooperativity and free-volume fluctuations in the non Arrhenius behavior of water self-diffusion: A continuity-of-states model. PMID- 9961551 TI - Phase diagram for excess electrons in simple fluids. PMID- 9961553 TI - Phase instabilities of oscillatory standing squares and alternating rolls. PMID- 9961552 TI - Scaling laws of the dissipation rate of turbulent subgrid-scale kinetic energy. PMID- 9961555 TI - Large-scale coherence and "anomalous scaling" of high-order moments of velocity differences in strong turbulence. PMID- 9961554 TI - Generation of swirl due to symmetry breaking. PMID- 9961556 TI - Separatrix-map analysis of chaotic transport in planar periodic vortical flows. PMID- 9961557 TI - Lagrangian path integrals and fluctuations in random flow. PMID- 9961558 TI - Estimation of productivity, efficiency, and entropy production for cyclic separation processes with a distributed working fluid. PMID- 9961559 TI - Korteweg-de Vries-Burgers equation for surface waves in nonideal conducting liquids. PMID- 9961560 TI - Simulation of nonideal gases and liquid-gas phase transitions by the lattice Boltzmann equation. PMID- 9961562 TI - Molecular interpretation of the absorption-induced optical reorientation of nematic liquid crystals. PMID- 9961561 TI - Influence of the surface profile on the roughness contribution to the ellipticity coefficient. PMID- 9961563 TI - Critical behavior at nematic-smectic-A phase transitions. PMID- 9961564 TI - Fractal and compact growth morphologies in phase transitions with diffusion transport. PMID- 9961565 TI - Depolarized-light-scattering study of orthoterphenyl and comparison with the mode coupling model. PMID- 9961567 TI - Influence of backflow on the reorientation dynamics of ferroelectric liquid crystals. PMID- 9961566 TI - Dynamic fluctuation effects in dilute lyotropic systems. PMID- 9961568 TI - Fluctuation-induced orientational correlations in polymer blends and diblock copolymer melts. PMID- 9961569 TI - Elasticity of weakly aggregating polystyrene latex dispersions. PMID- 9961570 TI - Quantum transport in porous media: Inelastic scattering of 4He atoms and its temperature dependence. PMID- 9961571 TI - Director configurations of nematic-liquid-crystal droplets: Negative dielectric anisotropy and parallel surface anchoring. PMID- 9961572 TI - Kinetics and thermodynamics of end-functionalized polymer adsorption and desorption processes. PMID- 9961573 TI - Hydrodynamic boundary conditions, correlation functions, and Kubo relations for confined fluids. PMID- 9961575 TI - Microphase separation in topologically constrained ring copolymers. PMID- 9961574 TI - Relaxation of electric birefringence near a critical consolute point. PMID- 9961577 TI - Phase transitions in heteropolymers with "secondary structure" PMID- 9961576 TI - Quasi-two-dimensional domain structures of magnetic particles in a static field. PMID- 9961578 TI - Dynamics of a bound membrane. PMID- 9961579 TI - Critical dynamics in liquids with long-range forces. PMID- 9961580 TI - Microscopic dynamics of liquid gallium. PMID- 9961582 TI - Slow dynamics in supercooled liquids. PMID- 9961581 TI - Optically induced hydrodynamic reorientation of liquid crystals and its applications for infrared detection and information storage. PMID- 9961583 TI - Model for eutectic organization: The purely kinetic regime. PMID- 9961584 TI - Low-frequency elastic response of a spherical particle. PMID- 9961585 TI - Structure factor of Cantor sets. PMID- 9961586 TI - Monte Carlo and integral-equation studies of hard-oblate-spherocylinder fluids. PMID- 9961587 TI - Stochastic envelope equations for nonequilibrium transitions and application to thermal fluctuations in electroconvection in nematic liquid crystals. PMID- 9961588 TI - Off-lattice Monte Carlo simulation of polymer brushes in good solvents. PMID- 9961589 TI - Textures in hexatic films of nonchiral liquid crystals: Symmetry breaking and modulated phases. PMID- 9961590 TI - Pretransitional fluctuations of the Lebwohl-Lasher model of a nematic liquid crystal. PMID- 9961591 TI - Diffusion-limited-aggregation processes with three-particle elementary reactions. PMID- 9961592 TI - Restructuring effects in irreversible deposition of spheres on a plane. PMID- 9961593 TI - Oscillatory relativistic motion of a particle in a power-law or sinusoidal-shaped potential well. PMID- 9961594 TI - Monte Carlo simulation of electron swarms at low reduced electric fields. PMID- 9961595 TI - Theory of Raman scattering for a short ultrastrong laser pulse in a rarefied plasma. PMID- 9961596 TI - Modeling and measurements on an obstructed glow discharge in helium. PMID- 9961597 TI - Negative-energy modes in a magnetically confined plasma in the framework of Maxwell-drift kinetic theory. PMID- 9961599 TI - Kinetic description of plasmas produced in multiphoton-ionization processes. PMID- 9961598 TI - Frequency downshift in rapidly ionizing media. PMID- 9961601 TI - Calculations of Smith-Purcell radiation generated by electrons of 1-100 MeV. PMID- 9961600 TI - Shear Alfven vortices in a current-carrying low-temperature plasma. PMID- 9961602 TI - Identifying chaotic electron trajectories in a helical-wiggler free-electron laser. PMID- 9961604 TI - Inverse method for the investigation of nonlinear instabilities associated with negative-energy modes. PMID- 9961603 TI - Oscillation mode and "nonlinear" radiation of the double sine-Gordon 2 pi kink. PMID- 9961606 TI - Dynamic stresses at a moving crack tip in a model of fracture propagation. PMID- 9961605 TI - Bifurcation phenomena and multiple soliton-bound states in isotropic Kerr media. PMID- 9961607 TI - Vector soliton associated with polarization modulational instability in the normal-dispersion regime. PMID- 9961608 TI - Interaction of discrete breathers with impurity modes. PMID- 9961609 TI - Analysis of a multistable dynamical system describing a competitive interaction between synapses on a neuron. PMID- 9961610 TI - Emergent collective behavior in large numbers of globally coupled independently stochastic ion channels. PMID- 9961611 TI - Monovariable representation of blood flow in a large elastic artery. PMID- 9961612 TI - Properties and origins of protein secondary structure. PMID- 9961613 TI - Nonlinear effects and thermal expansion as expressed in self-consistent phonon calculations on the temperature dependence of a phase change: Application to the B to Z conformation change in DNA. PMID- 9961614 TI - Fault-tolerant sensor integration using multiresolution decomposition. PMID- 9961616 TI - Multicanonical multigrid Monte Carlo method. PMID- 9961615 TI - Convergence accelerators in the computation of molecular integrals over Slater type basis functions in the two-range one-center expansion method. PMID- 9961618 TI - Synchronizationlike phenomena in coupled stochastic bistable systems. PMID- 9961617 TI - Singular perturbation analysis for unstable systems with convective nonlinearity. PMID- 9961619 TI - Longitudinal relaxation induced by colored noise. PMID- 9961621 TI - Nonequilibrium critical behavior from the master equation. PMID- 9961620 TI - Characterization of the Lorenz system, taking into account the equivariance of the vector field. PMID- 9961623 TI - Dynamic structure factors of a dense mixture. PMID- 9961622 TI - Monte Carlo calculation of effective diffusivities in two- and three-dimensional heterogeneous materials of variable structure. PMID- 9961625 TI - Microscopic simulation of dilute gases with adjustable transport coefficients. PMID- 9961624 TI - Instabilities and pattern formation in driven diffusive systems. PMID- 9961626 TI - Kinetic real-space renormalization-group approach to the shortest-path aggregation. PMID- 9961627 TI - Regular and stochastic acceleration of photons. PMID- 9961628 TI - Polarization stability of TE and TM waves in nonlinear planar waveguides. PMID- 9961629 TI - Alternative wave-function theory in homogeneous anisotropic media: Spline approximation. PMID- 9961630 TI - Experimental photon statistics of multiscattered light. PMID- 9961632 TI - Logarithmic decay of phi4 breathers of energy E <~ 1. PMID- 9961631 TI - Instability in a classical periodically driven string. PMID- 9961633 TI - Modulational instabilities in the discrete deformable nonlinear Schrodinger equation. PMID- 9961634 TI - Erratum: Tunneling control in a two-level system PMID- 9961635 TI - Cluster variation method, Pade approximants, and critical behavior. PMID- 9961636 TI - Self-organized criticality in the "game of Life" PMID- 9961637 TI - Role of parametric noise in nonintegrable quantum dynamics. PMID- 9961639 TI - Self-affinity of time series with finite domain power-law power spectrum. PMID- 9961638 TI - Eigenvector statistics in the crossover region between Gaussian orthogonal and unitary ensembles. PMID- 9961641 TI - Exactly solvable model of interface growth. PMID- 9961640 TI - Sign-singular measure and its association with turbulent scalings. PMID- 9961642 TI - Experimental control of chaos by means of weak parametric perturbations. PMID- 9961643 TI - Critical dynamics of contact line depinning. PMID- 9961644 TI - Spatiotemporal pulse collapse on periodic potentials. PMID- 9961646 TI - Stochastic perturbation of the gamma -ray angular correlation in the case of a quadrupole interaction. PMID- 9961645 TI - Renormalization-group study of a hybrid driven diffusive system. PMID- 9961648 TI - Exact results of a solvable general spin-1 model. PMID- 9961647 TI - Brownian parametric oscillators. PMID- 9961649 TI - Chaotic cascade model for turbulent velocity distributions. PMID- 9961650 TI - Hamiltonian approach to the dissociation of a coupled nonlinear exciton-vibron system. PMID- 9961651 TI - One-dimensional spherical model with a phase transition. PMID- 9961652 TI - Decay of metastable states with discrete dynamics. PMID- 9961653 TI - Chaos and the quantum-classical correspondence in the kicked pendulum. PMID- 9961654 TI - Brownian motion of two interacting particles under a square-well potential. PMID- 9961655 TI - Turbulent dynamics of an intrinsically chaotic field. PMID- 9961656 TI - Renormalization of the driven sine-Gordon equation in 2+1 dimensions. PMID- 9961657 TI - Post-Gaussian approximations in phase ordering kinetics. PMID- 9961658 TI - Dynamical scaling functions in conserved vector order-parameter systems without topological defects. PMID- 9961659 TI - Two-spin models with classical chaos and different quantum universality classes. PMID- 9961660 TI - Relaxation and stochasticity in a truncated Toda lattice. PMID- 9961661 TI - Statistical properties of spectra of pseudointegrable systems. PMID- 9961662 TI - Global stability of spherical polytropes. PMID- 9961663 TI - Crisis and enhancement of chaotic scattering. PMID- 9961664 TI - Thermodynamics of a two-dimensional self-gravitating system. PMID- 9961665 TI - Modeling and synchronizing chaotic systems from time-series data. PMID- 9961667 TI - Direct dynamical test for deterministic chaos and optimal embedding of a chaotic time series. PMID- 9961666 TI - Period-doubling bifurcations in the presence of colored noise. PMID- 9961669 TI - Periodic synchronization in a driven system of coupled oscillators. PMID- 9961668 TI - Natural boundaries for the Smoluchowski equation and affiliated diffusion processes. PMID- 9961670 TI - Fluctuations in a decentralized agent-resource system. PMID- 9961671 TI - Mapping of crystal surfaces onto the five-vertex model. PMID- 9961672 TI - Telegrapher's equations with variable propagation speeds. PMID- 9961673 TI - Monte Carlo simulations with indefinite and complex-valued measures. PMID- 9961674 TI - Late-stage phase separation: Dynamics, spatial correlations, and structure functions. PMID- 9961675 TI - Random driving of a nonlinear oscillator. PMID- 9961676 TI - Influence of noise on crisis-induced intermittency. PMID- 9961679 TI - Scaling properties of self-organized criticality. PMID- 9961677 TI - Stochastically averaged master equation for a quantum-dynamic system interacting with a thermal bath. PMID- 9961678 TI - Three-level quantum amplifier as a heat engine: A study in finite-time thermodynamics. PMID- 9961680 TI - Periodically kicked Duffing oscillator and nonattracting chaotic sets. PMID- 9961681 TI - Stochastic resonance in optical bistable systems. PMID- 9961682 TI - Model of spatiotemporal dynamics of stick-slip motion. PMID- 9961683 TI - Kinetics of heterogeneous condensation under dynamic conditions. PMID- 9961684 TI - Low-temperature anharmonic lattice deformations near rotator impurities: A quantum Monte Carlo approach. PMID- 9961685 TI - Crisis and intermittence in a leaky-faucet experiment. PMID- 9961686 TI - Rotational Brownian motion and dielectric relaxation of polar molecules subjected to a constant bias field: Exact solution. PMID- 9961688 TI - Nonlinear analysis of high-Reynolds-number flows over a buoyant axisymmetric body. PMID- 9961687 TI - Large-N limit of the "spherical model" of turbulence. PMID- 9961689 TI - Axisymmetric time-dependent flow in the Taylor-Couette system. PMID- 9961691 TI - Benard convection in a binary mixture with a nonlinear density-temperature relation. PMID- 9961690 TI - Scaling in drop distributions: An application in combustion. PMID- 9961692 TI - Extended universality in moderate-Reynolds-number flows. PMID- 9961693 TI - Intermittency and scaling property of band-pass-filtered signals in moderate Reynolds-number turbulent flows. PMID- 9961695 TI - Nonequilibrium effect of the turbulent-energy-production process on the inertial range energy spectrum. PMID- 9961694 TI - Simulation of a two-dimensional Rayleigh-Benard system using the direct simulation Monte Carlo method. PMID- 9961696 TI - Plume model for the boundary-layer dynamics in hard turbulence. PMID- 9961698 TI - Variational bounds on energy dissipation in incompressible flows: Shear flow. PMID- 9961697 TI - Competing states in a Couette-Taylor system with an axial flow. PMID- 9961700 TI - Dynamics of growing interfaces from the simulation of unstable flow in random media. PMID- 9961699 TI - Temporal forcing of small-amplitude waves in anisotropic systems. PMID- 9961701 TI - Light scattering on director fluctuations in smectic-A liquid crystals. PMID- 9961703 TI - Osmotic interactions between neutral surfaces in an electrolyte solution. PMID- 9961702 TI - Invasion percolation in a hydrostatic or permeability gradient: Experiments and simulations. PMID- 9961705 TI - Influence of substrate heterogeneities on the spreading of a drop. PMID- 9961704 TI - Phase separation and droplet nucleation induced by an optical piston. PMID- 9961706 TI - Spreading diffusion and its relation to sliding friction in molecularly thin adsorbed films. PMID- 9961707 TI - Replica model at low integer N for directed polymers in (1+1) dimensions. PMID- 9961708 TI - Percolation of two-dimensional attractive coagulated particles. PMID- 9961709 TI - Saffman-Taylor fingers with adverse anisotropic surface tension. PMID- 9961710 TI - Adsorption isotherm study of the fractal scaling behavior of vapor-deposited silver films. PMID- 9961711 TI - Rouse chain dynamics in layered random flows. PMID- 9961712 TI - Theory of surfacelike elastic contributions in nematic liquid crystals. PMID- 9961713 TI - Glass transition in colloidal hard spheres: Measurement and mode-coupling-theory analysis of the coherent intermediate scattering function. PMID- 9961714 TI - Reentrant smectic-C and smectic-C* phases in liquid crystals under an electric field. PMID- 9961715 TI - Spreading dynamics of polymer microdroplets: A molecular-dynamics study. PMID- 9961716 TI - Computer simulations of the breakup of colloid aggregates. PMID- 9961717 TI - Planar XY-model dynamics in a nematic liquid crystal system. PMID- 9961718 TI - Dynamic approach to phase separation of a mixture of monomers and polymers. PMID- 9961719 TI - Large deviations from the Clausius-Mossotti equation in a model microemulsion. PMID- 9961720 TI - Charge-frustrated model of bicontinuous phases. PMID- 9961721 TI - Formation of interfaces in bicontinuous phases. PMID- 9961722 TI - Distribution of density fluctuations in a molecular theory of vapor-phase nucleation. PMID- 9961724 TI - Supercooling of surface-modified phases. PMID- 9961723 TI - Spatiotemporal morphological transitions in thin-layer electrodeposition: The Hecker effect. PMID- 9961725 TI - Analytic model for planar growth of a solid germ from an undercooled melt. PMID- 9961726 TI - Influence of an inert electrolyte on the morphology of quasi-two-dimensional electrodeposits. PMID- 9961727 TI - Morphological instability in phase-field models of solidification. PMID- 9961729 TI - Long-term coherence of the cyclotron mode in a trapped ion cloud. PMID- 9961728 TI - Dynamic plasma response in laser-photodetachment experiments in hydrogen plasmas. PMID- 9961730 TI - Experimental evidence on the nonlocality of the electron distribution function. PMID- 9961731 TI - Diagnosis of laser-target implosions by space-resolved continuum absorption x-ray spectroscopy. PMID- 9961732 TI - Measurement of the electrical resistivity of a dense strongly coupled plasma. PMID- 9961734 TI - Propagation of short electron pulses in underdense plasmas. PMID- 9961733 TI - Argon-hydrogen plasma jet investigated by active and passive spectroscopic means. PMID- 9961735 TI - Spatial chaos and patterns in laser-produced plasmas. PMID- 9961736 TI - Adiabatic pair potential for charged particulates in plasmas and electrolytes. PMID- 9961737 TI - Polarization force on a charged particulate in a nonuniform plasma. PMID- 9961739 TI - Experimental study of the electrical conductivity of strongly coupled copper plasmas. PMID- 9961738 TI - Large-amplitude pulse response at the plasma boundary in an ion-beam system. PMID- 9961741 TI - Equalization of longitudinal and transverse beam cooling rates due to strong synchro-betatron interactions. PMID- 9961740 TI - Simulations of rf glow discharges in SF6 by the relaxation continuum model: Physical structure and function of the narrow-gap reactive-ion etcher. PMID- 9961742 TI - Anomalous equilibrium emittance due to chromaticity in electron storage rings. PMID- 9961744 TI - Linear analysis of periodic-waveguide cyclotron maser interaction. PMID- 9961743 TI - Femtosecond free-electron laser by chirped pulse amplification. PMID- 9961745 TI - Nonlinear Schrodinger soliton in a time-dependent quadratic potential. PMID- 9961746 TI - Renormalization group theory and variational calculations for propagating fronts. PMID- 9961748 TI - Propagation dynamics of ultrashort pulses in nonlinear fiber couplers. PMID- 9961747 TI - Bifurcations of the dark soliton and polarization domain walls in nonlinear dispersive media. PMID- 9961749 TI - Correlation in laser speckle. PMID- 9961750 TI - Self-similarity of friction laws. PMID- 9961751 TI - Kinks in the presence of rapidly varying perturbations. PMID- 9961753 TI - Efficient calculation of the Green's function for electromagnetic scattering by gratings. PMID- 9961752 TI - Light scattering in anisotropic stratified media. PMID- 9961754 TI - Influence of reflecting boundaries and finite interfacial thickness on the coherent backscattering cone. PMID- 9961755 TI - Green's function and lattice sums for electromagnetic scattering by a square array of cylinders. PMID- 9961756 TI - Kink stability, propagation, and length-scale competition in the periodically modulated sine-Gordon equation. PMID- 9961757 TI - Multiple-valued energy function in neural networks with asymmetric connections. PMID- 9961758 TI - Temperature effects in a nonlinear model of monolayer Scheibe aggregates. PMID- 9961759 TI - Query construction, entropy, and generalization in neural-network models. PMID- 9961760 TI - Statistical mechanics of neocortical interactions: Path-integral evolution of short-term memory. PMID- 9961761 TI - Order and disorder in fully hydrated unoriented bilayers of gel-phase dipalmitoylphosphatidylcholine. PMID- 9961763 TI - Solving the time-dependent Schrodinger equation numerically. PMID- 9961762 TI - Fast, accurate algorithm for numerical simulation of Levy stable stochastic processes. PMID- 9961764 TI - Scaling behavior of the punctuated-equilibrium model of evolution. PMID- 9961765 TI - Algebraic evaluation of linking numbers of unstable periodic orbits in chaotic attractors. PMID- 9961767 TI - Self-avoiding random walks on a family of diamond-type hierarchical lattices. PMID- 9961766 TI - Yang's model of charged particle scattering with energy loss. PMID- 9961768 TI - Mean first-passage time and multiexponential relaxation of the activationless nonadiabatic electron transfer reaction. PMID- 9961769 TI - Chaos in double-barrier heterostructures. PMID- 9961770 TI - Onset of avalanches in granular media. PMID- 9961771 TI - Cancellation exponents and fractal scaling. PMID- 9961772 TI - Surface roughening and surface diffusion in kinetic thin-film deposition. PMID- 9961773 TI - Phase separation dynamics of model thin films. PMID- 9961774 TI - Shape equations for axisymmetric vesicles: A clarification. PMID- 9961775 TI - Influence of many-particle effects on spectral line shapes in nonthermal plasmas. PMID- 9961776 TI - Stochastic substitute for coupled rate equations in the modeling of highly ionized transient plasmas. PMID- 9961777 TI - Stimulated Raman scattering of an EH waveguide mode near cyclotron resonance. PMID- 9961779 TI - Comment on "Thermodynamic properties of alpha -helix protein: A soliton approach" PMID- 9961778 TI - Interactions between monolayers and the stability of mixed surfactant vesicles. PMID- 9961780 TI - Reply to "Comment on 'Thermodynamic properties of alpha -helix protein: A soliton approach' " PMID- 9961781 TI - Erratum: Thermal and structural properties of the liquid-vapor interface in dipolar fluids PMID- 9961782 TI - Universality change in stochastic cellular automaton with applied site exchange. PMID- 9961784 TI - Competing effects of point versus columnar defects on the roughening of directed polymers in random media. PMID- 9961783 TI - Order in two-dimensional oscillator lattices. PMID- 9961785 TI - Fluctuating hydrodynamics of the classical electron gas. PMID- 9961786 TI - Inversion problem for dense classical liquids: The binary case. PMID- 9961787 TI - Transition to large aspect ratio convection. PMID- 9961788 TI - Phase dynamics near a parity-breaking instability. PMID- 9961789 TI - Average patterns in Faraday waves. PMID- 9961790 TI - Conformation of a single polyelectrolyte chain in the Coulombic unscreened limit. PMID- 9961791 TI - Surface tension of free-standing liquid-crystal films. PMID- 9961792 TI - Global phase diagrams for dipolar fluids. PMID- 9961793 TI - Possibility of twist-grain-boundary structure in nonchiral liquid crystals. PMID- 9961794 TI - Convex to concave transition and invariant distribution of segment lengths in many-walker anisotropic diffusion-limited aggregation. PMID- 9961796 TI - Transition from quasiperiodicity to chaos of a soliton oscillator. PMID- 9961795 TI - Stimulated Brillouin scattering with a 1 ps laser pulse in a preformed underdense plasma. PMID- 9961798 TI - Limitation on entropy increase imposed by Fisher information. PMID- 9961797 TI - Reversible axial segregation of binary mixtures of granular materials. PMID- 9961799 TI - Stochastic resonance: Nonperturbative calculation of power spectra and residence time distributions. PMID- 9961800 TI - Unidirectional adaptive dynamics. PMID- 9961801 TI - Synchronization of unstable orbits using adaptive control. PMID- 9961802 TI - Clustering behavior of time-delayed nearest-neighbor coupled oscillators. PMID- 9961803 TI - Catalysis on a fractal lattice: A model for poisoning. PMID- 9961804 TI - Minimum energy dissipation model for river basin geometry. PMID- 9961805 TI - Levy statistics in a Hamiltonian system. PMID- 9961806 TI - Multiplicative stochastic resonance. PMID- 9961807 TI - Drive-response scenario of chaos synchronization in identical nonlinear systems. PMID- 9961808 TI - Nonlinearly coupled generalized Fokker-Planck equation for rotational relaxation. PMID- 9961810 TI - Box-counting clustering analysis: Corrections for finite sample effects. PMID- 9961809 TI - Dimension of branching processes and self-organized criticality. PMID- 9961811 TI - Bivariate thermodynamic formalism and anomalous diffusion. PMID- 9961812 TI - Response of a stochastic bistable model driven by strong time-dependent fields. PMID- 9961813 TI - Phase-ordering dynamics of the O(n) model: Exact predictions and numerical results. PMID- 9961814 TI - Surmounting fluctuating barriers: A simple model in discrete time. PMID- 9961815 TI - Random walk for interacting particles on a Sierpinski gasket. PMID- 9961817 TI - Global vector-field reconstruction by using a multivariate polynomial L2 approximation on nets. PMID- 9961816 TI - Role of nonlinear dissipation in soft Duffing oscillators. PMID- 9961818 TI - Creep, stick-slip, and dry-friction dynamics: Experiments and a heuristic model. PMID- 9961819 TI - Cooperative behavior in the periodically modulated Wiener process: Noise-induced complexity in a model neutron. PMID- 9961820 TI - Green's function method for random fuse network problems. PMID- 9961821 TI - Stabilization of unstable steady states in an electrochemical system using derivative control. PMID- 9961822 TI - Scaling and density of Lee-Yang zeros in the four-dimensional Ising model. PMID- 9961824 TI - Dynamics of strongly dissipative systems. PMID- 9961823 TI - Slow relaxation and phase space properties of a conservative system with many degrees of freedom. PMID- 9961825 TI - Markov chain analysis of random walks in disordered media. PMID- 9961827 TI - Crossover from isotropic to directed percolation. PMID- 9961826 TI - Field-theory renormalization approach to the Kardar-Parisi-Zhang equation. PMID- 9961828 TI - Stochastic lattice gas model for a predator-prey system. PMID- 9961829 TI - Metastable lifetimes in a kinetic Ising model: Dependence on field and system size. PMID- 9961830 TI - Quantifying the closeness of fractal measures. PMID- 9961831 TI - Semiclassical theory of activated diffusion. PMID- 9961832 TI - Classical model of bosons and fermions. PMID- 9961833 TI - Classical model of intermediate statistics. PMID- 9961834 TI - Solution of the Percus-Yevick equation for pair-correlation functions of molecular fluids. PMID- 9961835 TI - Size and time dependence of the elastic constants of a two-dimensional solid near melting. PMID- 9961836 TI - Orientational and structural order in strongly interacting dipolar hard spheres. PMID- 9961837 TI - Rayleigh peak in a molecular fluid in the presence of a temperature gradient. PMID- 9961838 TI - Inhomogeneous random sequential adsorption with equilibrium initial conditions. PMID- 9961839 TI - Confined Brownian motion. PMID- 9961841 TI - Phase transitions in a continuum model of the classical Heisenberg magnet: The ferromagnetic system. PMID- 9961840 TI - Phase transitions in simple fluids: An application of a one-phase entropic criterion to Lennard-Jones and point Yukawa fluids. PMID- 9961843 TI - Development of a turbulence model based on recursion renormalization group theory. PMID- 9961842 TI - Synthetic turbulence. PMID- 9961844 TI - Complex spatiotemporal patterns in an open-flow reactor. PMID- 9961845 TI - Spatially forced corotating Taylor-Couette flow. PMID- 9961846 TI - Experimental evidence of self-excited relaxation oscillations leading to homoclinic behavior in spreading flames. PMID- 9961847 TI - Macroscopic and local orientational orders in nematic glass. PMID- 9961848 TI - Relationship between dielectric properties and critical behavior of the electric birefringence in binary liquid mixtures. PMID- 9961849 TI - Nature of the smectic-A-hexatic-B-crystal-E transitions in extremely thin films determined by optical reflectivity measurements. PMID- 9961850 TI - Dynamics of incompressible fluid membranes. PMID- 9961851 TI - Dependence of electrorheological response on conductivity and polarization time. PMID- 9961853 TI - Equilibrium shapes of a nematic-smectic-B liquid-crystal interface. PMID- 9961852 TI - Elastic equilibrium of curved thin films. PMID- 9961854 TI - Scaling analysis of narrow necks in curvature models of fluid lipid-bilayer vesicles. PMID- 9961855 TI - Multicomponent percolation: Probabilistic properties and application to nonisothermal reactions in granular materials. PMID- 9961856 TI - Percolation phenomenon in ternary microemulsions: The effect of pressure. PMID- 9961857 TI - Electrophoresis of charged polymers: Simulation and scaling in a lattice model of reptation. PMID- 9961858 TI - Critique of interatomic potentials obtained from neutron diffraction. PMID- 9961859 TI - Surface-pressure-induced conformation changes of a polymer liquid crystal at the air-water interface. PMID- 9961861 TI - Resummation of higher-order terms in the free-energy density of nematic liquid crystals. PMID- 9961860 TI - Hydrodynamic friction and the capacitance of arbitrarily shaped objects. PMID- 9961862 TI - Weighted-superposition approximation for x-ray and neutron reflectance. PMID- 9961863 TI - Stochastic contribution to the anchoring energy: Deviation from the Rapini Papoular expression. PMID- 9961864 TI - Surface effects on spinodal decomposition in binary mixtures and the interplay with wetting phenomena. PMID- 9961865 TI - Anchoring energy for nematic liquid crystals: Contribution from the spatial variation of the elastic constants. PMID- 9961867 TI - Diffusing-wave spectroscopy of a flowing foam. PMID- 9961866 TI - Budding transitions of fluid-bilayer vesicles: The effect of area-difference elasticity. PMID- 9961869 TI - Statics and dynamics of a polymer chain adsorbed on a surface: Monte Carlo simulation using the bond-fluctuation model. PMID- 9961868 TI - Continuum model of mode-III crack propagation with surface friction. PMID- 9961871 TI - Statistical mechanics of ionic colloids: Interparticle correlations and conformational equilibria in suspensions of polymer coated colloids. PMID- 9961870 TI - Scaling structure of tracer dispersion fronts in porous media. PMID- 9961872 TI - Transient structures in the twist Freedericksz transition of low-molecular-weight nematic liquid crystals. PMID- 9961874 TI - Monte Carlo simulations of a single polymer chain under an external force in two and three dimensions. PMID- 9961873 TI - Random walk and directed movement: Comparison between inert particles and self organized molecular machines. PMID- 9961875 TI - Directional solidification at high speed. I. Secondary instabilities. PMID- 9961876 TI - Directional solidification at high speed. II. Transition to chaos. PMID- 9961877 TI - Revised parametrization of the Dillmann-Meier theory of homogeneous nucleation. PMID- 9961878 TI - Exactly solvable models of irreversible adsorption with particle spreading. PMID- 9961879 TI - Theory of plasmons in quasi-one-dimensional degenerate plasmas. PMID- 9961880 TI - Attractors of dissipative structure in three dissipative fluids. PMID- 9961882 TI - Temporal relaxation of excited-level populations of atoms and ions in a plasma: Validity range of the quasi-steady-state solution of coupled rate equations. PMID- 9961881 TI - Angularly resolved observations of sidescattered laser light from laser-produced plasmas. PMID- 9961884 TI - Jeans instability of a dusty plasma. PMID- 9961883 TI - Simulation of negative-streamer dynamics in nitrogen. PMID- 9961885 TI - Two-dimensional, hybrid model of low-pressure glow discharges. PMID- 9961886 TI - Two-dimensional one-component plasma at coupling Gamma =4: Numerical study of pair correlations. PMID- 9961887 TI - Characterization of laser plasmas for interaction studies. PMID- 9961888 TI - Plasma diagnostics with spectral profile calculations. PMID- 9961889 TI - Space-resolved density diagnostic of a highly ionized holmium (Z=67) laser produced plasma from 3d104l-3d104l' Cu I-like lines. PMID- 9961890 TI - Generation of ultrafast electrons by simultaneous stimulated Raman backward and forward scattering. PMID- 9961892 TI - Dynamical behavior of a free-electron laser operating with a prebunched electron beam. PMID- 9961891 TI - Compensation of time-dependent persistent current effects in superconducting synchrotrons. PMID- 9961893 TI - Nonlinear properties of the Kapchinskij-Vladimirskij equilibrium and envelope equation for an intense charged-particle beam in a periodic focusing field. PMID- 9961894 TI - Model for negative-ion extraction, acceleration, and beam transport. PMID- 9961896 TI - Single particle dynamics at synchro-betatron coupling resonances. PMID- 9961895 TI - Effects of tune modulation on particles trapped in one-dimensional resonance islands. PMID- 9961897 TI - Parametric resonances in synchrotrons with two rf systems. PMID- 9961899 TI - Exact N-soliton solutions of the extended nonlinear Schrodinger equation. PMID- 9961898 TI - Time-dependent Beltrami fields in free space: Dyadic Green functions and radiation potentials. PMID- 9961900 TI - Approximate interacting solitary wave solutions for a pair of coupled nonlinear Schrodinger equations. PMID- 9961901 TI - Dynamics of solitonlike pulse propagation in birefringent optical fibers. PMID- 9961902 TI - Directed waves in random media: An analytical calculation. PMID- 9961904 TI - Structure of domain walls in an oscillator array. PMID- 9961903 TI - Soliton dynamics in periodically modulated directional couplers. PMID- 9961905 TI - Polarization properties of Maxwell-Gaussian laser beams. PMID- 9961906 TI - Vibration modes of a gap soliton in a nonlinear optical medium. PMID- 9961908 TI - Topological solitons in polyethylene crystals. PMID- 9961907 TI - Analytical theory of zone plate efficiency. PMID- 9961909 TI - Capacity of the multilayer perceptron with discrete synaptic couplings. PMID- 9961910 TI - Information processing of a complex system: Response behaviors specified by the Weierstrass function. PMID- 9961911 TI - Computation by symmetry operations in a structured model of the brain: Recognition of rotational invariance and time reversal. PMID- 9961912 TI - Critical phenomena in self-organizing feature maps: Ginzburg-Landau approach. PMID- 9961913 TI - Dynamical growth rate of a diffuse interface in first-order phase transitions. PMID- 9961915 TI - Stochastic resonance as crisis. PMID- 9961914 TI - Analysis of anomalous diffusion in the Kuramoto-Sivashinsky equation. PMID- 9961916 TI - Persistent correlations in the motion of a Brownian particle interacting with a finite-size random environment. PMID- 9961917 TI - Characterization of the attractor governing the neon bulb RC relaxation oscillator. PMID- 9961918 TI - Survival probability with random-force-dominated dynamics in the presence of traps. PMID- 9961919 TI - Phase transitions in a nonequilibrium Potts model: A Monte Carlo study of critical behavior. PMID- 9961920 TI - Formation of shocks and breakup of wave patterns in anisotropic excitable media. PMID- 9961922 TI - Separation ratio, Dufour number, and advection-diffusion equations of Lorentz gas mixtures. PMID- 9961921 TI - Solvent Stokes-Einstein violation in aqueous protein solutions. PMID- 9961923 TI - Simple model of trapping electrophoresis with complicated transient dynamics. PMID- 9961925 TI - Gap solitons in damped and parametrically driven nonlinear diatomic lattices. PMID- 9961924 TI - Plasma spectroscopy of n=4 to 3 C IV and N V lines in hot and dense plasmas. PMID- 9961926 TI - Canonical transformation between integrable Henon-Heiles systems. PMID- 9961927 TI - Evolution and extinction of families in cellular automata. PMID- 9961928 TI - Comment on "Fractal study of tertiary structure of proteins" PMID- 9961930 TI - Damage spreading during domain growth. PMID- 9961929 TI - Erratum: Order-parameter flow in the fully connected Hopfield model near saturation PMID- 9961931 TI - Traces of ghost orbits in the quantum standard map. PMID- 9961932 TI - Molecular dynamics simulations of hot, dense hydrogen. PMID- 9961933 TI - Probability distribution function of the temperature increment in isotropic turbulence. PMID- 9961934 TI - Fast thermalization in supercritical fluids. PMID- 9961935 TI - Transition to spatiotemporal chaos via spatially subharmonic oscillations of a periodic front. PMID- 9961936 TI - Domain growth laws for the phase ordering of chiral liquid crystals. PMID- 9961938 TI - Continuum approach to diffusion-limited-aggregation type of growth. PMID- 9961937 TI - Nature of the layer-by-layer transition associated with the smectic-A-crystal-B transition in free-standing liquid-crystal films. PMID- 9961939 TI - Interaction of subpicosecond KrF laser pulses with a preformed carbon plasma. PMID- 9961941 TI - Space-charge effects on nonlinear amplification of inverse bremsstrahlung electron acceleration. PMID- 9961940 TI - Measurements of radiation heat transport in germanium: Validationinebreak of an opacity model. PMID- 9961943 TI - Exact results for diffusion-limited reactions with synchronous dynamics. PMID- 9961942 TI - Hysteresis in neural networks. PMID- 9961944 TI - Structure and parameters of clusters in traffic flow. PMID- 9961945 TI - Scaling of Lyapunov exponents at nonsmooth bifurcations. PMID- 9961946 TI - Critical behavior of random walks. PMID- 9961947 TI - q bosons as quasifermions. PMID- 9961948 TI - Disorder-induced unbinding in confined geometries. PMID- 9961950 TI - Time-resolved optical spectrum for transient resonant light scattering. PMID- 9961949 TI - Resonant activation in a simple kinetic model. PMID- 9961952 TI - Chaos-assisted tunneling. PMID- 9961953 TI - Spatiotemporally periodic patterns in symmetrically coupled map lattices. PMID- 9961951 TI - Complexity in quantum systems. PMID- 9961955 TI - Chaotic patterns in a Josephson junction model. PMID- 9961954 TI - Projection dynamics of highly dissipative systems. PMID- 9961956 TI - Lattice models of failure: Sensitivity to the local dynamics. PMID- 9961957 TI - Dynamical simulation of a quantum harmonic oscillator in a noble-gas bath by density-matrix evolution. PMID- 9961958 TI - Non-neutral dynamics of splay states in Josephson-junction arrays. PMID- 9961959 TI - Nonequilibrium influence of upward atomic mobility in one-dimensional molecular beam epitaxy. PMID- 9961961 TI - Propagative slipping modes in a spring-block model. PMID- 9961960 TI - Discontinuous scaling of hysteresis losses. PMID- 9961962 TI - Predictability of self-organizing systems. PMID- 9961964 TI - Prerecorded history of a system as an experimental tool to control chaos. PMID- 9961963 TI - Stochastic multifractality and universal scaling distributions. PMID- 9961965 TI - Temperature and velocity boundary layers in turbulent convection. PMID- 9961966 TI - Convection in chemical waves. PMID- 9961967 TI - Multifractal scaling from nonlinear turbulence dynamics: Analytical methods. PMID- 9961968 TI - Hydrodynamics of fingering instabilities in dipolar fluids. PMID- 9961969 TI - Downstream evolution of the Benard-von Karman instability. PMID- 9961970 TI - Tracking unstable orbits in chaos using dissipative feedback control. PMID- 9961971 TI - Polymer systems with attractive interactions: Polyelectrolyte complex formation. PMID- 9961972 TI - Fractal growth in hydrodynamic dispersion through random porous media. PMID- 9961973 TI - Forces between polymer brushes: Monte Carlo simulation of a continuous-space model. PMID- 9961974 TI - Simulation study of a two-dimensional system of semiflexible polymers. PMID- 9961975 TI - Orientation of a solid particle embedded in a monodomain nematic liquid crystal. PMID- 9961976 TI - X-ray diffraction study of the smectic-A-tilde fluid antiphase and its transitions to smectic-A1 and smectic-A2 phases. PMID- 9961978 TI - Thermodynamic perturbation theory for association into chains and rings. PMID- 9961977 TI - Multiple front propagation into unstable states. PMID- 9961979 TI - Unusual lyotropic polymorphism of deoxyguanosine-5'-monophosphate: X-ray diffraction analysis of the correlation between self-assembling and phase behavior. PMID- 9961981 TI - Electrodeposition of a two-dimensional silver dendritic crystal under Langmuir monolayers. PMID- 9961980 TI - Universal scaling of fluid permeability for sphere packings. PMID- 9961982 TI - Textures of surfactant monolayers. PMID- 9961984 TI - Dynamics of concentration fluctuations in polymer solutions with spatiotemporal correlated noise. PMID- 9961983 TI - Wetting transition of a binary liquid due to suppression of electrostatic forces. PMID- 9961985 TI - Modified formula of nonlocal electron transport in a laser-produced plasma. PMID- 9961986 TI - Theory of strong-electromagnetic-wave propagation in an electron-positron-ion plasma. PMID- 9961987 TI - Model of a laser heated plasma interacting with walls arising in laser keyhole welding. PMID- 9961988 TI - Solution of the effective wave equation by perturbation theory in a dense hydrogen plasma. PMID- 9961989 TI - Transient ultrahigh gains as a diagnostic in short-pulse heated selenium plasmas. PMID- 9961990 TI - Plasma instabilities in high electric fields. PMID- 9961991 TI - Electron velocity distribution function at low electron densities in the positive column of a helium gas discharge. PMID- 9961993 TI - Nonlinear theory of magnetic fluctuations in random flow: The Hall effect. PMID- 9961992 TI - Nonlinear theory of surface-wave-particle interactions in a cylindrical plasma. PMID- 9961994 TI - Asymptotic behavior of guiding-center diffusion in a model of electrostatic turbulence. PMID- 9961995 TI - Bootstrap current generation by symmetrically injected lower-hybrid waves in a tokamak plasma. PMID- 9961996 TI - Electron-temperature and electron-density profiles in an atmospheric-pressure argon plasma jet. PMID- 9961998 TI - Integrable polynomial factorization for symplectic systems. PMID- 9961997 TI - Transverse equilibria and luminosity enhancement in linear collider beam-beam collisions. PMID- 9962000 TI - Charge distribution and electric field effects on spatiotemporal patterns. PMID- 9961999 TI - Multiperiodic orbits in a pendulum with a vertically oscillating pivot. PMID- 9962001 TI - Inversion of conductivity profiles using the Volterra functional method. PMID- 9962002 TI - Influence of molecular reorientation on electronic energy transfer between a pair of mobile chromophores: The stochastic Liouville equation combined with Brownian dynamic simulation techniques. PMID- 9962004 TI - Computational capabilities of restricted two-layered perceptrons. PMID- 9962003 TI - Numerical method for large-scale non-Hermitian matrices and its application to percolating Heisenberg antiferromagnets. PMID- 9962005 TI - Chaos and avoided level crossings. PMID- 9962006 TI - Annihilation reaction A+A-->0 with diffusion and interaction between particles in disordered structures. PMID- 9962008 TI - Kinetics of two-species ballistic annihilation. PMID- 9962007 TI - Practical considerations in the control of chaos. PMID- 9962009 TI - Generalization of the Kolmogorov -5/3 law of turbulence. PMID- 9962010 TI - Phase transition of molecular orientation at the liquid-air interface. PMID- 9962011 TI - Model incorporating deposition, diffusion, and aggregation in submonolayer nanostructures. PMID- 9962012 TI - Multilinear perceptron convergence theorem. PMID- 9962013 TI - Comment on "Spiral-pattern formation in Rayleigh-Benard convection" PMID- 9962014 TI - Erratum: Activated decay rate: Finite-barrier corrections PMID- 9962016 TI - Density patterns in two-dimensional hoppers. PMID- 9962015 TI - Superconducting billiard cavities with chaotic dynamics: An experimental test of statistical measures. PMID- 9962017 TI - Corner spontaneous magnetization. PMID- 9962018 TI - Advanced chaos forecasting. PMID- 9962020 TI - Spectra of fluctuations of velocity, kinetic energy, and the dissipation rate in strong turbulence. PMID- 9962019 TI - Dynamics of hard-sphere suspensions. PMID- 9962022 TI - Inelastic collapse in two dimensions. PMID- 9962021 TI - Class of nonsingular exact solutions for Laplacian pattern formation. PMID- 9962023 TI - Calorimetric investigation of the smectic-C-smectic-I transition in free-standing p-decyloxybenzylidene-p-amino-2-methylbutylcinnamate films. PMID- 9962025 TI - Ring dark solitons. PMID- 9962024 TI - Wake-field effect induced by laser multiple pulses. PMID- 9962026 TI - Nonlinear resonance for the oscillator with a nonmonotonic dependence of eigenfrequency on energy. PMID- 9962027 TI - Physics of a random biological process. PMID- 9962029 TI - Mean-field Monte Carlo approach to the Sherrington-Kirkpatrick model with asymmetric couplings. PMID- 9962028 TI - Parametrically driven microparticle in the presence of a stationary zero-mean stochastic source: Model for thermal equilibrium in the Paul trap. PMID- 9962030 TI - Quantum dynamics of molecular motions based on a functional method. PMID- 9962031 TI - Suppression of deterministic diffusion by noise. PMID- 9962032 TI - Localized structures and front propagation in the Lengyel-Epstein model. PMID- 9962033 TI - Inhibition of chaos in Hamiltonian systems by periodic pulses. PMID- 9962034 TI - Fractal characterization of two-dimensional aluminum corrosion fronts. PMID- 9962035 TI - First-order kinetic phase transitions in simple reactions on solid surfaces: Nucleation and growth of the stable phase. PMID- 9962036 TI - Wave-packet initial motion, spreading, and energy in the periodically kicked pendulum. PMID- 9962037 TI - Thermally activated escape over time-modulated fluctuating barriers. PMID- 9962038 TI - Selection of length distributions in living polymers. PMID- 9962039 TI - Road to fractals in a Yang-Mills system. PMID- 9962041 TI - Generating functional approach to space- and time-dependent colored noise. PMID- 9962040 TI - Kac's solution of the telegrapher's equation for tunneling time analysis: An application of the wavelet formalism. PMID- 9962042 TI - Kinetics of clustering in traffic flows. PMID- 9962043 TI - Long-range correlations in degenerate multicomponent systems of charged fermions. PMID- 9962044 TI - Energy localization and delocalization in a nonlinear chain on a substrate. PMID- 9962046 TI - Influence of boundary reflection and refraction on diffusive photon transport. PMID- 9962045 TI - Statistical cycling in coupled map lattices. PMID- 9962047 TI - Crumpled phases of self-avoiding randomly polymerized membranes. PMID- 9962048 TI - Symmetry in phase space for a system with a singular higher-order Lagrangian. PMID- 9962049 TI - Chaos and quantum thermalization. PMID- 9962051 TI - Quasienergy-band structure of a periodically driven system with translational symmetry. PMID- 9962050 TI - Floquet analysis of quantum resonance in a driven nonlinear system. PMID- 9962053 TI - Controlling chaos experimentally in systems exhibiting large effective Lyapunov exponents. PMID- 9962052 TI - Solid-on-solid models of molecular-beam epitaxy. PMID- 9962055 TI - Exact solutions for stochastic adsorption-desorption models and catalytic surface processes. PMID- 9962054 TI - Exact long-time behavior of a network of phase oscillators under random fields. PMID- 9962056 TI - Hypersensitivity to perturbation in the quantum kicked top. PMID- 9962058 TI - Stick-slip dynamics in the relaxation of stresses in a continuous elastic medium. PMID- 9962057 TI - Generalized Markov coarse graining and spectral decompositions of chaotic piecewise linear maps. PMID- 9962059 TI - Numerical study of a morphology diagram in the large undercooling limit using a phase-field model. PMID- 9962060 TI - Scaling laws and simulation results for the self-organized critical forest-fire model. PMID- 9962061 TI - Simple model for quantum chaos. PMID- 9962062 TI - Two-loop renormalization-group analysis of the Burgers-Kardar-Parisi-Zhang equation. PMID- 9962063 TI - Scaling and crossover in the large-N model for growth kinetics. PMID- 9962065 TI - Thermodynamics of attractor enlargement. PMID- 9962064 TI - Estimation of a Lyapunov-exponent spectrum of plasma chaos. PMID- 9962066 TI - Absence of chaos in a self-organized critical coupled map lattice. PMID- 9962067 TI - Eigenspectrum and localization for diffusion with traps. PMID- 9962068 TI - Passage rates of propagating interfaces in randomly advected media and heterogeneous media. PMID- 9962070 TI - Winding-angle distribution for Brownian and self-avoiding walks. PMID- 9962069 TI - Current-current correlation function in a driven diffusive system with nonconserving noise. PMID- 9962071 TI - Damage spreading in the Ziff-Gulari-Barshad model. PMID- 9962072 TI - Binary-collision contributions to atomic motions in fluids. PMID- 9962073 TI - Transport in a random medium with spatial correlations. PMID- 9962074 TI - Structure of confined adhesive fluids: A Monte Carlo study. PMID- 9962075 TI - Self- and cross-velocity correlation functions and diffusion coefficients in liquids: A molecular dynamics study of binary mixtures of soft spheres. PMID- 9962076 TI - Interplay of reaction and transport in a perfect fluid. PMID- 9962077 TI - Sound propagation in magnetic fluids. PMID- 9962079 TI - Wave number selection in convection and related problems. PMID- 9962078 TI - Periodic states in intermittent pipe flows: Experiment and model. PMID- 9962080 TI - Marangoni convection in binary liquids. PMID- 9962082 TI - Pattern selection at the onset of Rayleigh-Benard convection in a horizontal shear flow. PMID- 9962081 TI - Vortex filament stability and boundary layer dynamics. PMID- 9962084 TI - Brownian dynamics of hard spherocylinders. PMID- 9962083 TI - Hamilton-Lagrange formalism of nonequilibrium thermodynamics. PMID- 9962085 TI - Molecular dynamics simulations of phase separation in the presence of surfactants. PMID- 9962086 TI - Alternative method of investigating surface torsional anchoring energy for pure nematic liquid crystals. PMID- 9962087 TI - Elastic response of the Dirac chain. PMID- 9962089 TI - Viscoelasticity of concentrated dispersions. PMID- 9962088 TI - Fluctuating hydrodynamics and diffusion in amorphous solids. PMID- 9962090 TI - Vapor-liquid phase equilibrium in random microporous matrices. PMID- 9962091 TI - Order parameter in the vicinity of the double critical point of stratification. PMID- 9962092 TI - Application of the dynamical droplet model to critical nonionic amphiphile-water micellar solutions. PMID- 9962094 TI - Statistical mechanics of proteins with "evolutionary selected" sequences. PMID- 9962093 TI - Dimple and nose coalescences in phase-separation processes. PMID- 9962095 TI - Percolation phenomenon on fluorinated perfluoropolyether water in oil microemulsions: The effect of temperature. PMID- 9962097 TI - Fluctuating interfaces in microemulsion and sponge phases. PMID- 9962096 TI - Extraction of the bridge function for simple liquids from a molecular dynamics simulation and its application for correcting the pair distribution function. PMID- 9962098 TI - Molecular-dynamics simulation on simple fluids: Departure from linearized hydrodynamic behavior of the dynamical structure factor. PMID- 9962100 TI - Mean shape of three-dimensional dendrites: A comparison of pivalic acid and ammonium chloride. PMID- 9962099 TI - Low-frequency ac electrical resistivity of liquid gallium and its relationship with the dynamic structure factor. PMID- 9962102 TI - Studies of aggregation kinetics of polystyrene latices sterically stabilized by poly(N-isopropylacrylamide). PMID- 9962101 TI - Influence of global coupling through the gas phase on the dynamics of CO oxidation on Pt(110). PMID- 9962103 TI - Fractal to nonfractal behavior of vapor-deposited gold surfaces and the relationship to the substrate temperature. PMID- 9962105 TI - Soft-x-ray amplification in a capillary discharge. PMID- 9962104 TI - Nucleation of long-range order in quenched Yukawa plasmas. PMID- 9962107 TI - Dependence of turbulent mixing on the initial roughness in the evaporation front with continuous density profile at the interface. PMID- 9962106 TI - Absorption spectroscopy on the argon first excited state in an expanding thermal arc plasma. PMID- 9962108 TI - Electric field strengths, ion energy distributions, and ion density decay for low pressure, moderate-current nitrogen discharges. PMID- 9962109 TI - Fokker-Planck simulations of short-pulse-laser-solid experiments. PMID- 9962110 TI - Scattering of electromagnetic waves in dusty plasmas with variable charges on dust particles. PMID- 9962111 TI - Effect of longitudinal modulation of Alfven wave filamentation. PMID- 9962112 TI - Numerical analysis of quasiperiodic perturbations for the Alfven wave. PMID- 9962113 TI - Renormalization-group theory of plasma microturbulence. PMID- 9962114 TI - Exponentially temporally growing magnetic moment field of stimulated Brillouin scattering in plasma. PMID- 9962115 TI - Near-equilibrium multiple-wave plasma states. PMID- 9962116 TI - Diagnostics of an electron beam of a linear accelerator using coherent transition radiation. PMID- 9962118 TI - Microwave inverse free-electron-laser accelerator using a small "phase window" PMID- 9962117 TI - Effect of a polarized hydrogen target on the polarization of a stored proton beam. PMID- 9962119 TI - Radial focusing of a relativistic electron beam in a bipotential electrostatic lens. PMID- 9962120 TI - Longitudinal and transverse impedance of an iris in a beam pipe. PMID- 9962122 TI - Resonant splitting of a vector soliton in a periodically inhomogeneous birefringent optical fiber. PMID- 9962121 TI - Fokker-Planck approach to the dynamics of mismatched charged-particle beams. PMID- 9962123 TI - Coupled higher-order nonlinear Schrodinger equations in nonlinear optics: Painleve analysis and integrability. PMID- 9962124 TI - Analytical one-dimensional model to study the ultrasonic precursor generated by a laser. PMID- 9962125 TI - Envelope soliton propagation in media with temporally modulated dispersion. PMID- 9962126 TI - Generalized Euler equations for linked rigid bodies. PMID- 9962127 TI - Optical domain walls. PMID- 9962128 TI - Forced Bonhoeffer-van der Pol oscillator in its excited mode. PMID- 9962129 TI - Phase diagram of microtubules. PMID- 9962130 TI - Dynamical and critical behavior of a simple discrete model of the cellular immune system. PMID- 9962131 TI - Oscillations, complex spatiotemporal behavior, and information transport in networks of excitatory and inhibitory neurons. PMID- 9962132 TI - Pseudorandom number generator for massively parallel molecular-dynamics simulations. PMID- 9962133 TI - Boundary conditions for the Schrodinger equation in the numerical simulation of quantum systems. PMID- 9962134 TI - Parallel simulation of the Ising model. PMID- 9962135 TI - Simulation of phase ordering kinetics in conserved scalar systems with long-range interactions. PMID- 9962136 TI - Effect of a chirp on soliton production. PMID- 9962137 TI - Intermittency in a stochastic birth-death model. PMID- 9962138 TI - Synchronization of chaos using continuous control. PMID- 9962139 TI - Equilibrium microstates which generate second law violating steady states. PMID- 9962140 TI - Crossover region in the aggregation of colloids. PMID- 9962141 TI - Bifurcations of homoclinic orbits in bimodal maps. PMID- 9962142 TI - Langevin equations for continuous time Levy flights. PMID- 9962143 TI - Dynamics of curved domain boundaries in convection patterns. PMID- 9962144 TI - Kuppers-Lortz instability in a rapidly rotating inviscid magnetoconvection. PMID- 9962146 TI - Water content in micelles and the Laplace formula. PMID- 9962145 TI - Lower bound for transport for passive advection. PMID- 9962147 TI - Surface-induced nucleation. PMID- 9962148 TI - Micellar growth in hexagonal phases of lipid systems. PMID- 9962150 TI - Nematic liquid crystals between antagonistic cylinders: Spirals with bend-splay director undulations. PMID- 9962149 TI - Frequency shift of a quartz crystal oscillator bounded by a self-affine fractal rough surface in contact with a liquid. PMID- 9962152 TI - Stationary convection in a cylindrical plasma. PMID- 9962151 TI - Orientation symmetry breakings in shearing liquid crystals. PMID- 9962153 TI - Solitary electrostatic waves in a thin plasma slab. PMID- 9962154 TI - Nonlocal electron transport in the presence of high-intensity laser irradiation. PMID- 9962155 TI - Weak chaos in one-dimensional quantum transport: The 1/f2 law and the breakdown of the law of large numbers. PMID- 9962156 TI - Model for an enzymatic reaction-diffusion system realizing storage of graded information. PMID- 9962157 TI - Period-doubling bifurcations and chaos in the decremental propagation of a spike train in excitable media. PMID- 9962158 TI - Reexamination of the depolarized-light-scattering spectra of glass-forming liquids. PMID- 9962160 TI - Reply to "Comment on 'Light-scattering investigation of alpha and beta relaxation near the liquid-glass transition of the molecular glass Salol' " and "Reexamination of the depolarized-light-scattering spectra of glass-forming liquids" PMID- 9962159 TI - Comment on "Light-scattering investigation of alpha and beta relaxation near the liquid-glass transition of the molecular glass Salol" PMID- 9962161 TI - Erratum: Neural networks optimally trained with noisy data PMID- 9962162 TI - Dynamic fuse model for electromigration failure of polycrystalline metal films. PMID- 9962163 TI - Lacunarity, fractal, and magnetic transition behaviors in a generalized Eden growth process. PMID- 9962165 TI - Scaling theory of depinning in the Sneppen model. PMID- 9962164 TI - Width distribution for random-walk interfaces. PMID- 9962166 TI - Some simple chaotic flows. PMID- 9962167 TI - Optimization by multicanonical annealing and the traveling salesman problem. PMID- 9962169 TI - Parametric S-matrix fluctuations in the quantum theory of chaotic scattering. PMID- 9962168 TI - Rate concept and retarded master equations for dissipative tight-binding models. PMID- 9962170 TI - Time-dependent gradients of growing interfaces. PMID- 9962171 TI - Elastic excitable medium. PMID- 9962172 TI - Scale similarity of the velocity structure functions in fully developed magnetohydrodynamic turbulence. PMID- 9962173 TI - Small-angle neutron-scattering study of dense sheared silica gels. PMID- 9962174 TI - Energy spectra of quasiperiodic systems via information entropy. PMID- 9962175 TI - Free-energy profiles and scaling in polymer brushes. PMID- 9962176 TI - Relativistic self-focusing and channel formation in laser-plasma interactions. PMID- 9962177 TI - X-ray reemission from CH foils heated by laser-generated intense thermal radiation. PMID- 9962178 TI - Moving solitons in the damped Ablowitz-Ladik model driven by a standing wave. PMID- 9962179 TI - Structure in the electric potential emanating from DNA. PMID- 9962180 TI - Statistical mechanics of the maximum-likelihood density estimation. PMID- 9962181 TI - Failure of dimension analysis in a simple five-dimensional system. PMID- 9962182 TI - Intrinsic irreversibility and the validity of the kinetic description of chaotic systems. PMID- 9962183 TI - Theory of Levy matrices. PMID- 9962185 TI - Importance of interfacial coupling on the formation and growth of metastable phases. PMID- 9962184 TI - Scaling exponents for turbulence and other random processes and their relationships with multifractal structure. PMID- 9962186 TI - Propagation and extinction in branching annihilating random walks. PMID- 9962187 TI - Estimation of the dimension of a noisy attractor. PMID- 9962188 TI - Application of the slaving principle to nonlinear non-Markovian systems. PMID- 9962190 TI - State scarring by "ghosts" of periodic orbits. PMID- 9962189 TI - Synchronous chaos in coupled oscillator systems. PMID- 9962191 TI - Synchronization of spatiotemporal chaotic systems by feedback control. PMID- 9962192 TI - Phase-ordering kinetics of one-dimensional nonconserved scalar systems. PMID- 9962193 TI - Phase transition in a heteropolymer chain at a selective interface. PMID- 9962194 TI - Critical behavior of period doubling in coupled area-preserving maps. PMID- 9962195 TI - Numerical transfer-matrix study of a model with competing metastable states. PMID- 9962196 TI - Decay of quasibounded classical Hamiltonian systems and their internal dynamics. PMID- 9962197 TI - Applying algorithmic complexity to define chaos in the motion of complex systems. PMID- 9962198 TI - History-dependent control of unstable periodic orbits. PMID- 9962199 TI - Crossover in rescaled-range analysis and power spectra: Measurements and simulations. PMID- 9962200 TI - Mean exit times for free inertial stochastic processes. PMID- 9962202 TI - Krypton clusters adsorbed on graphite: A low-temperature commensurate incommensurate transition. PMID- 9962201 TI - Chaotic scattering in the presence of an external magnetic field. PMID- 9962203 TI - Temperature dependence of pair correlations and correlation entropy in a fluid. PMID- 9962205 TI - Phase diagram for coherent vortex formation in the two-dimensional inviscid fluid in circular geometries. PMID- 9962204 TI - Turbulent domain stabilization in annular flows. PMID- 9962206 TI - Nonlinear hydrodynamic instability of expanding flames: Intrinsic dynamics. PMID- 9962207 TI - Interface dynamics and domain growth in thermally bistable fluids. PMID- 9962208 TI - Low-wave-number statistics of randomly advected passive scalars. PMID- 9962209 TI - Translation-rotation paradox for diffusion in fragile glass-forming liquids. PMID- 9962210 TI - Size-dependent scaling of capillary invasion including buoyancy and pore size distribution effects. PMID- 9962212 TI - Experimental determination of the effective splay-bend elastic constant. PMID- 9962211 TI - Single-chain statistics and the upper wave-vector cutoff in polymer blends. PMID- 9962213 TI - Contaminant diffusion in a random array of fixed parallel cylinders at high Reynolds numbers. PMID- 9962214 TI - Dielectric study of the electroclinic effect in the smectic-A phase. PMID- 9962215 TI - "Soliton" solutions in a field theory of microemulsion. PMID- 9962216 TI - Walls of orientation induced in nematic-liquid-crystal samples by inhomogeneous surfaces. PMID- 9962217 TI - Direct evaluation of length scales and structural parameters associated with flow in porous media. PMID- 9962218 TI - Equilibrium properties of a polymer chain in an Euler fluid. PMID- 9962219 TI - Kinetic properties of ballistic aggregation. PMID- 9962221 TI - Continuum description of noiseless diffusion-limited aggregation. PMID- 9962220 TI - NO-CO surface reaction on a square lattice. PMID- 9962223 TI - Temporal characteristics of backscattered light from a KrF laser-produced plasma. PMID- 9962222 TI - Optimization of K-shell emission in aluminum z-pinch implosions: Theory versus experiment. PMID- 9962224 TI - Two-dimensional stimulated Brillouin scattering. PMID- 9962225 TI - Time-resolved x-ray fluorescence of He-like ions in an aluminum-laser-produced plasma. PMID- 9962226 TI - Induced electrostatic fields in dense plasmas with an intense ultrashort pulse laser. PMID- 9962227 TI - Efficient K alpha x-ray source from femtosecond laser-produced plasmas. PMID- 9962228 TI - Effect of a large-amplitude wave on the one-dimensional velocity distribution of particles in a linearized Fokker-Planck collisional plasma. PMID- 9962229 TI - Propagation velocity of Alfven wave packets in a dissipative plasma. PMID- 9962230 TI - Theory of electron retardation by Langmuir probes in anisotropic plasmas. PMID- 9962232 TI - Variational approach to the Zakharov-Shabat scattering problem. PMID- 9962231 TI - Space and time dependence of the electric field and plasma induced emission in transient and steady-state hollow cathode discharges. PMID- 9962233 TI - Gap solitons in anharmonic one-dimensional asymmetrical physical systems with Kac Baker long-range interactions. PMID- 9962234 TI - Hamiltonians for discrete dynamics. PMID- 9962235 TI - Benjamin-Feir-type instability in a saturated ferrite: Transition between focusing and defocusing regimes for polarized electromagnetic waves. PMID- 9962236 TI - Birefringence by a smoothly inhomogeneous locally isotropic medium: Three dimensional case. PMID- 9962237 TI - Localized excitations in two-dimensional Hamiltonian lattices. PMID- 9962239 TI - Dynamics of compartmental model recurrent neural networks. PMID- 9962238 TI - Characteristics of spatiotemporal fluctuations of temperature in living tissue. PMID- 9962241 TI - Continuous feedback approach for controlling chaos. PMID- 9962240 TI - Extensions to the distributed approximating functional: The harmonic propagator. PMID- 9962242 TI - Kinetics in coagulation-annihilation processes. PMID- 9962243 TI - Nonlinear feedback for controlling the Lorenz equation. PMID- 9962244 TI - Stabilizing unstable periodic orbits in a fast diode resonator using continuous time-delay autosynchronization. PMID- 9962245 TI - Time-dependent density-functional theory with H theorems. PMID- 9962246 TI - Nonequilibrium statistical-mechanical approach to discrete-time dynamics. PMID- 9962248 TI - Anomalous segregation at a single trap in disordered chains. PMID- 9962247 TI - Proliferation law of periodic orbits of an integrable billiard as obtained from the eigenvalue spectrum. PMID- 9962249 TI - Interfacial finger cells in a system coupling steady Soret-driven convection and solidification. PMID- 9962250 TI - Generalized nonlinear impurity in a linear chain. PMID- 9962251 TI - X-ray or neutron reflectivity: Limitations in the determination of interfacial profiles. PMID- 9962252 TI - Self-consistent mean-field calculation of surface segregation in a binary polymer blend. PMID- 9962253 TI - Brownian dynamics simulations of self-diffusion and shear viscosity of near-hard sphere colloids. PMID- 9962254 TI - Statistics of Stokes variables for correlated Gaussian fields. PMID- 9962255 TI - Erratum: Critical dimensionalities of phase transitions on fractals PMID- 9962256 TI - Oscillatory instability of crack propagations in quasistatic fracture. PMID- 9962257 TI - Molecular dynamics simulations of self-avoiding tethered membranes with attractive interactions: Search for a crumpled phase. PMID- 9962258 TI - Simulations of deposition growth models in various dimensions: The possible importance of overhangs. PMID- 9962260 TI - Pattern selection of multicrack propagation in quenched crystals. PMID- 9962259 TI - Extended self-similarity in the numerical simulation of three-dimensional homogeneous flows. PMID- 9962262 TI - Flow-induced scattering peak in the structure factor of polymer solutions. PMID- 9962261 TI - Phase separation in a dilute polymer solution in a metastable region. PMID- 9962263 TI - Lifetime of undercooled wetting layers. PMID- 9962264 TI - Onset of convection in molecular dynamics simulations of grains. PMID- 9962265 TI - Induced stochastic resonance near a subcritical bifurcation. PMID- 9962266 TI - Boundary-induced drift of spirals in excitable media. PMID- 9962267 TI - Crossover from percolation to self-organized criticality. PMID- 9962268 TI - Punctuated equilibrium and "history-dependent" percolation. PMID- 9962269 TI - Overlap, disorder, and directed polymers: A renormalization group approach. PMID- 9962270 TI - Transforming signs to phase distributions in quantum simulations. PMID- 9962271 TI - Surface forces, undulating bilayers, and nuclear-spin relaxation. PMID- 9962272 TI - Passages and droplets in lamellar fluid membrane phases. PMID- 9962273 TI - Topological instabilities and phase behavior of fluid membranes. PMID- 9962274 TI - Multiparticle aggregation model for dendritic growth applied to experiments on amorphous Co-P alloys. PMID- 9962275 TI - Langmuir wave instability in a dusty plasma. PMID- 9962276 TI - Describing RNA sequential folding by dynamic coarse graining of the extended conformation space. PMID- 9962277 TI - Effective medium approximation for random walks with non-Markovian dynamical disorder. PMID- 9962278 TI - Mesoscopic derivation of hyperbolic transport equations. PMID- 9962280 TI - Front propagation in a random medium with a power-law distribution of transit times. PMID- 9962279 TI - Fokker-Planck equation for nonequilibrium competing dynamic models. PMID- 9962281 TI - Kinetics of heterogeneous single-species annihilation. PMID- 9962282 TI - Growth, self-randomization, and propagation in a Lorentz lattice gas. PMID- 9962283 TI - Ward identities for surface-growth models with diffusion. PMID- 9962285 TI - Bistable kinetic model driven by correlated noises: Steady-state analysis. PMID- 9962284 TI - 1/f noise and one-dimensional Brownian motion in a singular potential. PMID- 9962287 TI - Threshold devices: Fractal noise and neural talk. PMID- 9962286 TI - Hysteresis loss and stochastic resonance: A numerical study of a double-well potential. PMID- 9962288 TI - Phase ordering dynamics of cosmological models. PMID- 9962289 TI - Decoherence produces coherent states: An explicit proof for harmonic chains. PMID- 9962290 TI - Controlling unstable states in reaction-diffusion systems modeled by time series. PMID- 9962291 TI - Chaos and a quantum-classical correspondence in the kicked top. PMID- 9962292 TI - Dynamical approach to anomalous diffusion: Response of Levy processes to a perturbation. PMID- 9962294 TI - 1/f noise in the beta decay of 90Sr-90Y. PMID- 9962293 TI - Synchronizing chaotic systems using filtered signals. PMID- 9962295 TI - Chaotic scattering on C4v four-disk billiards: Semiclassical and exact quantum theories. PMID- 9962297 TI - Dynamics of a nonlinear lattice with randomly distributed masses. PMID- 9962296 TI - Steady-state density in annihilation of immobile reactants with input of particles. PMID- 9962299 TI - Entropy of the symbolic sequence for critical circle maps. PMID- 9962298 TI - Quasiequilibria in one-dimensional self-gravitating many-body systems. PMID- 9962300 TI - Nature of the Gaussian approximations in phase-ordering kinetics. PMID- 9962302 TI - Multifractality and multiscaling in collision cascades. PMID- 9962301 TI - Chaos and linear response: Analysis of the short-, intermediate-, and long-time regime. PMID- 9962304 TI - Synchronization effects in the dynamical behavior of elevators. PMID- 9962303 TI - Relationship between variational transition state theory and the Rayleigh quotient method for activated rate processes. PMID- 9962306 TI - Non-Markovian noise. PMID- 9962305 TI - Partially asymmetric exclusion process with open boundaries. PMID- 9962307 TI - Rigorous verification of chaos in a molecular model. PMID- 9962308 TI - Computer simulation study of inelastic neutron scattering from liquid water. PMID- 9962309 TI - Brownian dynamics of rigid polymer chains with hydrodynamic interactions. PMID- 9962310 TI - Cascade models for magnetohydrodynamic turbulence. PMID- 9962311 TI - Roll-rectangle transition in the magnetic fluid Faraday instability. PMID- 9962313 TI - Stable, unstable, and defected confined states of traveling-wave convection. PMID- 9962312 TI - Effective Ampere force in developed magnetohydrodynamic turbulence. PMID- 9962314 TI - Phase dynamics of patterns: The effect of boundary-induced amplitude variations. PMID- 9962315 TI - Thermal lattice Bhatnagar-Gross-Krook model without nonlinear deviations in macrodynamic equations. PMID- 9962316 TI - Universality in fully developed turbulence. PMID- 9962317 TI - Predicting time-dependent motion in the double-diffusive convection system. PMID- 9962318 TI - Stochastic simulations of high-Reynolds-number turbulence in two dimensions. PMID- 9962319 TI - Pattern formation in the presence of symmetries. PMID- 9962320 TI - Dynamical test of interaction potentials for colloidal suspensions. PMID- 9962321 TI - Nucleated wetting films: The late-time behavior. PMID- 9962322 TI - Optical confirmation of the extended mean-field theory for a smectic-C*-smectic-A transition. PMID- 9962323 TI - Model disordered media provided by ternary microemulsions. PMID- 9962325 TI - Effect of polydispersity on the isotropic-nematic phase transition of rigid rods. PMID- 9962324 TI - How the choice of shape and ensemble affect simulations of two-dimensional melting. PMID- 9962326 TI - Computer simulation of self-assembling processes of a binary mixture containing a block copolymer. PMID- 9962328 TI - Dilation sheath of smectic-A focal-conic singular lines. PMID- 9962327 TI - X-ray studies of the hexatic phase in liquid crystals with a crystal-B-hexatic-B smectic-A phase sequence. PMID- 9962329 TI - Strain-induced instabilities in hexagonal columnar phases. PMID- 9962330 TI - Fast, immiscible fluid-fluid displacement in three-dimensional porous media at finite viscosity contrast. PMID- 9962331 TI - Mixed fluid bilayers: Effects of confinement. PMID- 9962332 TI - Phase transitions in a "many-letter" random heteropolymer. PMID- 9962333 TI - Nematic ordering and microphase segregation in a diblock polymer-liquid-crystal polymer. PMID- 9962335 TI - Maxwell equations in nematic liquid crystals. PMID- 9962334 TI - van der Waals theory for solids. PMID- 9962337 TI - Landau-de Gennes theory of the chevron structure in a smectic-A liquid crystal. PMID- 9962336 TI - Computer simulations of nematic droplets with bipolar boundary conditions. PMID- 9962338 TI - Formulating a first-principles statistical theory of growing surfaces in two dimensional Laplacian fields. PMID- 9962339 TI - Self-assembly of rodlike particles in two dimensions: A simple model for collagen fibrillogenesis. PMID- 9962340 TI - Reversible aggregation in self-associating polymer systems. PMID- 9962342 TI - Stark broadening of triply ionized oxygen lines: The temperature dependence. PMID- 9962341 TI - Short-range screening potentials for classical Coulomb fluids: Monte Carlo sampling and cluster model studies. PMID- 9962343 TI - Langmuir-probe characteristic in the presence of drifting electrons. PMID- 9962344 TI - Different class of two-dimensional shocks in magnetized plasmas. PMID- 9962345 TI - Monte Carlo treatment of the transport of electrons in a gas including electron electron interactions. PMID- 9962346 TI - Transition from a Townsend discharge to a normal discharge via two-dimensional modeling. PMID- 9962347 TI - Two-dimensional nonuniformly heated magnetized plasma transport in a conducting vessel. PMID- 9962348 TI - CO2 laser absorption measurements of temperature and density in the shock-induced Richtmyer-Meshkov mixing zone. PMID- 9962349 TI - Linear hydromagnetic waves in an ultrarelativistic, collisionless plasma with a pressure anisotropy. PMID- 9962350 TI - Numerical study of the detailed structure of the ion resonance cone. PMID- 9962351 TI - Modulational interaction of short-wavelength ion-acoustic oscillations in impurity-containing plasmas. PMID- 9962352 TI - Generation of a subpicosecond relativistic electron single bunch at the S-band linear accelerator. PMID- 9962353 TI - Electron beam quality in a cyclotron autoresonance accelerator. PMID- 9962354 TI - Transit-time method of optical stochastic cooling. PMID- 9962355 TI - Decompaction modes of a two-dimensional "sandpile" under vibration: Model and experiments. PMID- 9962356 TI - Simulations of two-dimensional arrays of beads under external vibrations: Scaling behavior. PMID- 9962357 TI - Depolarized light scattering from fractal soot aggregates. PMID- 9962358 TI - Exact solution of the wave dynamics of a particle bouncing chaotically on a periodically oscillating wall. PMID- 9962359 TI - Internal friction between solitons in near-integrable systems. PMID- 9962360 TI - Conditions on the existence of localized excitations in nonlinear discrete systems. PMID- 9962361 TI - Lattice sums for off-axis electromagnetic scattering by gratings. PMID- 9962362 TI - Standing localized modes in nonlinear lattices. PMID- 9962363 TI - Theory of correlations in stochastic neural networks. PMID- 9962364 TI - Generalization in the programed teaching of a perceptron. PMID- 9962365 TI - Learning to classify in large committee machines. PMID- 9962367 TI - Model fermion Monte Carlo method with antithetical pairs. PMID- 9962366 TI - Numerical solution of the Boltzmann equation in cylindrical geometry. PMID- 9962368 TI - Synchronization of coupled maps and stable windows. PMID- 9962369 TI - Remarks on "Constant-temperature molecular dynamics with momentum conservation" PMID- 9962371 TI - Symbolic analysis of attractor geometry for the Lozi map. PMID- 9962370 TI - Ising critical behavior of a non-Hamiltonian lattice system. PMID- 9962372 TI - Stabilizing unstable periodic orbits in fast dynamical systems. PMID- 9962373 TI - Stochastic resonance in an autonomous system with a nonuniform limit cycle. PMID- 9962374 TI - Properties of wide-peak autosolitons in electron-hole and gas plasmas. PMID- 9962375 TI - Space-time nonlocal model for heat conduction. PMID- 9962376 TI - Vesicle model of linear- and branched-polymer theta collapses. PMID- 9962378 TI - Kink solitons in quadratic-cubic nonlinear dispersive media. PMID- 9962377 TI - Structure of an electrorheological fluid in steady shear. PMID- 9962379 TI - Condition for kink immobility in trigger systems with limited elimination of an inhibitor. PMID- 9962380 TI - Stability of light beams in nonlinear antiwaveguides. PMID- 9962381 TI - Comment on "Relationship between McQuarrie and Helfand equations for the determination of shear viscosity from equilibrium molecular dynamics" PMID- 9962382 TI - Three-dimensional Ising system with long-range interactions: A computer model of Vycor glass. PMID- 9962383 TI - Dynamics of interfaces in a model for molecular-beam epitaxy. PMID- 9962384 TI - Locking and Arnold tongues in an infinite-dimensional system: The nuclear magnetic resonance laser with delayed feedback. PMID- 9962385 TI - Dissipative transport with correlated noise. PMID- 9962386 TI - Diffusion of fractal aggregates in the free molecular regime. PMID- 9962387 TI - Vortices and strings in a model ecosystem. PMID- 9962388 TI - Controlling unstable steady states using system parameter variation and control duration. PMID- 9962390 TI - Quantal-classical mixed-mode dynamics and chaotic behavior. PMID- 9962389 TI - Breakdown of ergodic behavior in the Lorentz gas. PMID- 9962391 TI - Computer simulations of conductance noise in a dynamical percolation resistor network. PMID- 9962392 TI - Adiabatic chaos in Josephson-junction arrays. PMID- 9962394 TI - Controlling hyperchaos in a multimode laser model. PMID- 9962393 TI - Statistical characterization of Barkhausen noise. PMID- 9962395 TI - Fragmentation of particles with more than one degree of freedom. PMID- 9962396 TI - Effect of vertical vibrations on avalanches in granular systems. PMID- 9962397 TI - Fractal basin boundaries in coupled map lattices. PMID- 9962398 TI - Two-temperature nonequilibrium Ising models: Critical behavior and universality. PMID- 9962399 TI - Growth kinetics for a system with a conserved order parameter. PMID- 9962401 TI - Resonancelike responses of autonomous nonlinear systems to white noise. PMID- 9962400 TI - Scaling and multiscaling in models of fragmentation. PMID- 9962402 TI - Sign of corrections to scaling amplitudes: Field-theoretic considerations and results for self-repelling walks. PMID- 9962404 TI - Width distribution for (2+1)-dimensional growth and deposition processes. PMID- 9962403 TI - Interpolating between ferromagnets and spin glasses. PMID- 9962405 TI - Transient multimodality in relaxation from an unstable state. PMID- 9962406 TI - Dynamics of particle deposition on a disordered substrate. I. Near-equilibrium behavior. PMID- 9962407 TI - Internal fluctuations, period doubling, and chemical chaos. PMID- 9962408 TI - Number of degrees of freedom for a thermostat. PMID- 9962410 TI - Subdiffusive transients in area-preserving mappings. PMID- 9962409 TI - Periodicity and chaos in a one-dimensional dynamical model of earthquakes. PMID- 9962411 TI - Effects of structure on transport coefficients in a random medium. PMID- 9962412 TI - Width distribution of curvature-driven interfaces: A study of universality. PMID- 9962413 TI - Defect coarsening and spin waves in the nonlinear sigma model. PMID- 9962414 TI - Gaussian wave-packet dynamics: Semiquantal and semiclassical phase-space formalism. PMID- 9962415 TI - Quantum resonances due to classical stability islands. PMID- 9962416 TI - Critical exponents for branching annihilating random walks with an even number of offspring. PMID- 9962418 TI - Dynamics of discrete models of binary mixtures in two dimensions: Exact solution. PMID- 9962417 TI - Diffusion approximation for a dissipative random medium and the applications. PMID- 9962419 TI - Time-dependent reactivity for diffusion-controlled annihilation and coagulation in two dimensions. PMID- 9962420 TI - Computer simulation study of liquid lithium at 470 and 843 K. PMID- 9962421 TI - Noise amplification in open Taylor-Couette flow. PMID- 9962422 TI - Measurement of the scaling of the dissipation at high Reynolds numbers. PMID- 9962423 TI - Exact fronts for the nonlinear diffusion equation with quintic nonlinearities. PMID- 9962424 TI - Chaos transition despite linear stability. PMID- 9962425 TI - Burst and collapse in traveling-wave convection of a binary fluid. PMID- 9962426 TI - Multifractality of large turbulent fluctuations and the topology of strange attractors. PMID- 9962427 TI - Driven front and interface of a fluid-flow model in 2+1 dimensions. PMID- 9962429 TI - Columnar and smectic order in binary mixtures of aligned hard cylinders. PMID- 9962428 TI - Nonlinear optical studies of binary mixtures of hydrogen bonded liquids. PMID- 9962430 TI - Thermal hydrodynamic fluctuations in microemulsions. PMID- 9962432 TI - New Freedericksz thresholds in three dimensions. PMID- 9962431 TI - Optical second-harmonic generation during switching in a ferroelectric liquid crystal cell. PMID- 9962433 TI - Surface adsorption of branched polymers: Mapping onto the Yang-Lee edge singularity and exact results for three dimensions. PMID- 9962434 TI - Burst process of stretched fiber bundles. PMID- 9962435 TI - Random multiblock copolymer-homopolymer blends: Effect of sequence distribution and intramolecular repulsion. PMID- 9962436 TI - Ferroelectric phase in Stockmayer fluids. PMID- 9962437 TI - Nonlinear compaction of an assembly of highly deformable platelike particles. PMID- 9962439 TI - Phase transitions in a continuum model of the classical Heisenberg magnet: The antiferromagnetic system. PMID- 9962438 TI - Biaxiality of chiral liquid crystals. PMID- 9962440 TI - Dynamics of lyotropic ferronematic liquid crystals submitted to magnetic fields. PMID- 9962441 TI - Molecular-dynamics study of supercooled ortho-terphenyl. PMID- 9962442 TI - Numerical investigation of two-dimensional projections of random fractal aggregates. PMID- 9962443 TI - Universal direct cascade in two-dimensional turbulence. PMID- 9962444 TI - Domain patterns in incommensurate systems with the uniaxial real order parameter. PMID- 9962446 TI - Two distinct time scales in the dynamics of a dense hard-sphere liquid. PMID- 9962445 TI - Molecular dynamics simulation of tethered membranes in four and five dimensions. PMID- 9962447 TI - Saha equation for two-temperature plasmas: Theories, experimental evidence, and interpretation. PMID- 9962449 TI - Evolution of the electron distribution function in intense laser-plasma interactions. PMID- 9962448 TI - Production of strongly coupled plasmas by the laser irradiation of thin metallic films confined within micrometer-scale gaps by transparent insulators. PMID- 9962450 TI - Dynamics of particles trapping and detrapping in coherent wave packets. PMID- 9962451 TI - Ion wake fields in a plasma with negative ions. PMID- 9962452 TI - Multiple cutoff wave numbers of the ablative Rayleigh-Taylor instability. PMID- 9962454 TI - Self-consistent charge dynamics and collective modes in a dusty plasma. PMID- 9962453 TI - Electron densities and temperatures in a xenon afterglow with heavy-ion excitation. PMID- 9962455 TI - Plasma properties near the anode surface of an ion diode determined by high resolution laser spectroscopy. PMID- 9962456 TI - Langmuir-probe measurements in flowing-afterglow plasmas. PMID- 9962457 TI - Enhanced ion acoustic fluctuations in laser-produced plasmas. PMID- 9962458 TI - Transport integral: A method to calculate the time evolution of phase-space distributions. PMID- 9962459 TI - Linear theory of the free-electron laser with a two-frequency undulator. PMID- 9962460 TI - Effect of space charge on transverse instabilities in synchrotrons. PMID- 9962461 TI - C-caronerenkov radiation from a finite trajectory of electrons. PMID- 9962463 TI - Slippage and scattering of light pulses in hole-coupled free-electron lasers. PMID- 9962462 TI - Experimental measurements of a betatron difference resonance. PMID- 9962464 TI - Simulation of the formation and detection of one-dimensional ordered ion beams. PMID- 9962465 TI - Propagation of Gaussian beams in a nonlinear saturable medium. PMID- 9962467 TI - Field representations in composite chiral-ferrite media by cylindrical vector wave functions. PMID- 9962466 TI - Light propagation in a cylindrical waveguide with a complex, metallic, dielectric function. PMID- 9962468 TI - Anomalous energy dissipation in molecular-dynamics simulations of grains: The "detachment" effect. PMID- 9962469 TI - Granular relaxation under tapping and the traffic problem. PMID- 9962471 TI - Mechanisms for determining the time scales in vesicle budding. PMID- 9962470 TI - Pattern structures on generalized nonlinear Schrodinger equations with various nonlinear terms. PMID- 9962472 TI - Neural network model for the coordinated formation of orientation preference and orientation selectivity maps. PMID- 9962473 TI - Storage of structured patterns in a neural network. PMID- 9962474 TI - Entropy, pattern entropy, and related methods for the analysis of data on the time intervals between heartbeats from 24-h electrocardiograms. PMID- 9962475 TI - Global stability and local stability of Hopfield neural networks with delays. PMID- 9962476 TI - Multifractal analysis of imprecise data: Badii-Politi and correlation integral approaches. PMID- 9962477 TI - Simulated-tempering procedure for spin-glass simulations. PMID- 9962478 TI - Inverse avalanches on Abelian sandpiles. PMID- 9962479 TI - Crisis control: Preventing chaos-induced capsizing of a ship. PMID- 9962480 TI - Semianalytical approach to x-ray and neutron reflection from surface films. PMID- 9962482 TI - Extension of "Renormalization of period doubling in symmetric four-dimensional volume-preserving maps" PMID- 9962481 TI - Irreversible thermodynamic analysis of two-layer systems. PMID- 9962483 TI - Self-consistent solution of phase separation with competing interactions. PMID- 9962484 TI - Fractal structure of a dissipative particle-fluid system in a time-dependent chaotic flow. PMID- 9962486 TI - Multifractal phenomenology and the refined similarity hypothesis in turbulence. PMID- 9962485 TI - Waves and solitary pulses in a weakly inhomogeneous Ginzburg-Landau system. PMID- 9962487 TI - Self-affine case for the roughness effect on the frictional force in boundary lubrication. PMID- 9962489 TI - Hybrid mode analysis of a slow-wave free-electron laser with a rectangular guide loaded with two slabs of dielectric. PMID- 9962488 TI - Parametric resonance of a vortex in an active medium. PMID- 9962490 TI - Erratum: Kardar-Parisi-Zhang model and anomalous elasticity of two- and three dimensional smectic-A liquid crystals PMID- 9962492 TI - Scaling of reaction zones in the A+B-->0 diffusion-limited reaction. PMID- 9962491 TI - Erratum: Characterization of laser plasmas for interaction studies PMID- 9962493 TI - Self-organized pulse generator in a reaction-diffusion system. PMID- 9962494 TI - On-off intermittency in random map lattices. PMID- 9962495 TI - Control of dynamical tunneling in a bichromatically driven pendulum. PMID- 9962496 TI - Infinitely divisible distributions in turbulence. PMID- 9962497 TI - Multiple bubbles in a Hele-Shaw cell. PMID- 9962498 TI - Domain wall between traveling waves. PMID- 9962499 TI - Optical smoothing techniques for shock wave generation in laser-produced plasmas. PMID- 9962500 TI - Density functional theory of molecular fluids: Free-energy model for the inhomogeneous hard-body fluid. PMID- 9962501 TI - Effect of a net charge on the conformation of polyampholytes. PMID- 9962502 TI - Brownian-dynamics simulation studies of a charge-stabilized colloidal suspension under shear flow. PMID- 9962503 TI - Dynamical scaling of fractal aggregates in dense colloidal solutions. PMID- 9962504 TI - Soft-x-ray radiation from plasmas produced by obliquely incident subpicosecond laser pulses. PMID- 9962506 TI - Determination of a charged-particle-bunch shape from the coherent far infrared spectrum. PMID- 9962505 TI - Particle-in-cell simulations of Raman forward scattering from short-pulse high intensity lasers. PMID- 9962507 TI - Landau-Ginzburg equation for the cyclotron resonance maser. PMID- 9962508 TI - Bifurcation of resonance islands and Landau damping in the double-rf system. PMID- 9962509 TI - Surface shape of a spinning bucket of sand. PMID- 9962510 TI - Motion of a polyelectrolyte chain hooked around a post. PMID- 9962512 TI - Memory-flow structures in Lorenz chaos. PMID- 9962511 TI - Interface propagation and nucleation phenomena for discontinuous poisoning transitions in surface-reaction models. PMID- 9962513 TI - Analytic approach to the space-time kinetics of annihilation reactions. PMID- 9962515 TI - Constant thermodynamic speed for minimizing entropy production in thermodynamic processes and simulated annealing. PMID- 9962514 TI - Dendrites and fronts in a model of dynamical rupture with damage. PMID- 9962516 TI - Random fractals, phase transitions, and negative dimension spectra. PMID- 9962517 TI - Conditions for the appearance of wave chaos in quantum singular systems with a pointlike scatterer. PMID- 9962519 TI - Quantum kinetic theory of irreversible thermodynamics: Low-density gases. PMID- 9962518 TI - First-order phase transitions in the Montorsi-Rasetti model. PMID- 9962520 TI - Complex unstable periodic orbits and their manifestation in classical and quantum dynamics. PMID- 9962522 TI - Clusters in point distributions. PMID- 9962521 TI - Numerical study of a field theory for directed percolation. PMID- 9962523 TI - Folding transition of the triangular lattice. PMID- 9962524 TI - Grazing bifurcations in impact oscillators. PMID- 9962526 TI - Avalanches in the weakly driven Frenkel-Kontorova model. PMID- 9962525 TI - Dynamics of particle deposition on a disordered substrate. II. Far-from equilibrium behavior. PMID- 9962529 TI - Inhomogeneous random sequential adsorption on bipartite lattices. PMID- 9962528 TI - Braid analysis of a bouncing ball. PMID- 9962527 TI - Synchronization of chaotic systems: The effects of additive noise and drift in the dynamics of the driving. PMID- 9962530 TI - Bose-Einstein condensation in a system of q-bosons. PMID- 9962531 TI - Automata network predator-prey model with pursuit and evasion. PMID- 9962532 TI - Surface shape and local critical behavior: The percolation problem in two dimensions. PMID- 9962533 TI - Steady states of a column of shaken inelastic beads. PMID- 9962534 TI - Numerical simulation of the Kardar-Parisi-Zhang equation. PMID- 9962535 TI - Jam phases in a two-dimensional cellular-automaton model of traffic flow. PMID- 9962536 TI - Correlation functions in chaotic systems from periodic orbits. PMID- 9962537 TI - Diffusion in lattice Lorentz gases with mixtures of point scatterers. PMID- 9962538 TI - Hydrodynamic behavior of lattice Boltzmann and lattice Bhatnagar-Gross-Krook models. PMID- 9962540 TI - Nonequilibrium molecular dynamics simulation of free-molecule gas flows in complex geometries with application to Brownian motion of aggregate aerosols. PMID- 9962539 TI - Phonon gas: A lattice Boltzmann description. PMID- 9962541 TI - Dynamic dielectric response function of liquid water. PMID- 9962542 TI - Theory of fluctuations in high electric fields. PMID- 9962543 TI - Diffusion of single particles in cellular media. PMID- 9962545 TI - Tracer dispersion in planar multipole flows. PMID- 9962544 TI - Influence of the critical curvature on spiral initiation in an excitable medium. PMID- 9962546 TI - Equation of motion for interacting pulses. PMID- 9962547 TI - Analogies between scaling in turbulence, field theory, and critical phenomena. PMID- 9962548 TI - Anomalous scaling in fluid mechanics: The case of the passive scalar. PMID- 9962549 TI - Statistical mechanics of shell models for two-dimensional turbulence. PMID- 9962550 TI - Laser-pulse sputtering of aluminum: Vaporization, boiling, superheating, and gas dynamic effects. PMID- 9962551 TI - Modeling of one-dimensional weakly nonlinear waves that propagate in media with arbitrary dissipation and dispersion mechanisms. PMID- 9962552 TI - Linear electro-optic effect in a cholesteric liquid crystal. PMID- 9962553 TI - Interfacial properties in lattice gases: A density functional approach. PMID- 9962555 TI - Comparison of quasifree excess electron and positron states in simple molecular fluids: Methane and silane. PMID- 9962554 TI - Integral equations for a fluid near a random substrate. PMID- 9962556 TI - Percolation phenomenon and the study of conductivity, viscosity, and ultrasonic velocity in microemulsions. PMID- 9962557 TI - Dielectric response of surface stabilized ferroelectric liquid crystal cells. PMID- 9962558 TI - Pitch-induced transition of chiral nematic liquid crystals in submicrometer cylindrical cavities. PMID- 9962559 TI - Specific heat dependence on orientational order at cylindrically confined liquid crystal phase transitions. PMID- 9962561 TI - Density functional theory of crystal-fluid interfaces and surface melting. PMID- 9962560 TI - Dielectric relaxation and rotational viscosity of a ferroelectric liquid crystal mixture. PMID- 9962562 TI - Brownian dynamics of suspensions of rodlike particles. PMID- 9962563 TI - Ultrasonic spectroscopy in nonionic micellar solutions far from and near to Tc. PMID- 9962565 TI - Wetting phenomena and the decay of correlations at fluid interfaces. PMID- 9962564 TI - Diffuse-transmission spectroscopy: A structural probe of opaque colloidal mixtures. PMID- 9962566 TI - Brillouin scattering in glass-forming liquids: q-dependent linewidths and the generalized viscosity. PMID- 9962568 TI - Spinodal decomposition in an order-disorder phase transition with elastic fields. PMID- 9962567 TI - Practical method for calculation of multiple light scattering. PMID- 9962569 TI - Isostructural solid-solid transition in crystalline systems with short-ranged interaction. PMID- 9962570 TI - Modified reptation model. PMID- 9962571 TI - Long-scale deformations of resonant three-dimensional patterns and the structure of confined dislocations. PMID- 9962572 TI - Scaling theory for multipolymer coagulation. PMID- 9962573 TI - Inhomogeneous nucleation in first-order phase transitions. PMID- 9962574 TI - Stochastic dynamic simulation of the Boltzmann equation for electron swarms in glow discharges. PMID- 9962575 TI - Temporal behavior of x-ray radiation emitted by subpicosecond KrF-laser-heated carbon preplasmas. PMID- 9962576 TI - Fokker-Planck analysis of short-pulse laser heating in the hot-spot-model approximation. PMID- 9962577 TI - Reflectivity of cold magnetized plasmas. PMID- 9962578 TI - Free-energy model for fluid atomic helium at high density. PMID- 9962580 TI - Simulation of the secondary-electron distribution function by a Monte Carlo method. PMID- 9962579 TI - Heating of underdense plasmas by intense short-pulse lasers. PMID- 9962581 TI - Free-electron-laser simulations: Effects of beam quality and space charge. PMID- 9962582 TI - Transverse laser cooling induced through dispersion at an rf cavity. PMID- 9962583 TI - Entropy production in multiple scattering of light by a spatially random medium. PMID- 9962584 TI - Scattering of guided waves in a waveguide with a slightly rough boundary: Stochastic functional approach. PMID- 9962585 TI - Constraint on linear, homogeneous, constitutive relations. PMID- 9962587 TI - DNA electrophoretic collisions with single obstacles. PMID- 9962586 TI - Dark solitons in discrete lattices. PMID- 9962588 TI - Denaturation temperature of DNA. PMID- 9962589 TI - Nonmonotonic behavior of the capacity in phasor neural networks. PMID- 9962590 TI - Theory of the structure factor of lipid bilayers. PMID- 9962591 TI - Entropies of biosequences: The role of repeats. PMID- 9962592 TI - Kinetic evidence for protein clustering at a surface. PMID- 9962593 TI - Periodic forcing of a limit-cycle oscillator: Fixed points, Arnold tongues, and the global organization of bifurcations. PMID- 9962594 TI - Statistical mechanical treatment of the structural hydration of biological macromolecules: Results for B-DNA. PMID- 9962596 TI - Kinematics of vorticity: Vorticity-strain conjugation in incompressible fluid flows. PMID- 9962595 TI - Parallel implementation of many-body mean-field equations. PMID- 9962597 TI - Concise calculation of the scaling function, exponents, and probability functional of the Edwards-Wilkinson equation with correlated noise. PMID- 9962598 TI - Time decay of excitations at quasi-one-dimensional trapping. PMID- 9962599 TI - Reaction dynamics controlled by enhanced diffusion. PMID- 9962600 TI - Density functional approach to solvent-induced interactions in neutral liquids: Comparison with experimental results. PMID- 9962601 TI - Relative velocity fluctuations in turbulence. PMID- 9962603 TI - Ion acoustic waves in plasmas with collisional electrons. PMID- 9962602 TI - Supersonic radiative heat waves in low-density high-Z material. PMID- 9962605 TI - Soliton stability in a bimodal optical fiber in the presence of the Raman effect. PMID- 9962604 TI - Size segregation in a two-dimensional sandpile: Convection and arching effects. PMID- 9962607 TI - Erratum: Dimension of branching processes and self-organized criticality PMID- 9962606 TI - Erratum: Diffusion in equilibrium mixtures of ionized gases PMID- 9962609 TI - Lattice ribbons: A model of double-stranded polymers. PMID- 9962608 TI - Dynamical renormalization group analysis of fourth-order conserved growth nonlinearities. PMID- 9962610 TI - Hydrodynamic stability of compressible plane Couette flow. PMID- 9962611 TI - Subcritical-supercritical bifurcation crossover in directional solidification. PMID- 9962612 TI - Phase separation of binary fluids confined in a cylindrical pore: A molecular dynamics study. PMID- 9962614 TI - Analysis of resonant structures of four-dimensional symplectic mappings, using normal forms. PMID- 9962613 TI - Measurement of the longitudinal asymmetry of a charged particle bunch from the coherent synchrotron or transition radiation spectrum. PMID- 9962615 TI - Chaotic scattering theory of transport and reaction-rate coefficients. PMID- 9962616 TI - Reduction of optical chaos by a quantum correction in second-harmonic generation of light. PMID- 9962617 TI - Brownian motion on a square Lennard-Jones lattice: Trapping, hopping, and diffusion. PMID- 9962618 TI - Geometric description of chaos in self-gravitating systems. PMID- 9962619 TI - Density-functional approach to the equation of state of a hard-sphere crystal. PMID- 9962621 TI - Frequency distributions in population genetics parallel those in statistical physics. PMID- 9962620 TI - Spectral signature of the pitchfork bifurcation: Liouville equation approach. PMID- 9962622 TI - Preserving chaos: Control strategies to preserve complex dynamics with potential relevance to biological disorders. PMID- 9962624 TI - Expansion of moments of the Smoluchowski equation. PMID- 9962625 TI - Retrapping and velocity inversion in jump diffusion. PMID- 9962623 TI - Statistics of wave-function scars. PMID- 9962626 TI - Reliability of self-affine measurements. PMID- 9962627 TI - Properties of autowaves including transitions between the traveling and static solitary states. PMID- 9962628 TI - Thermodynamic pressure in nonequilibrium gases. PMID- 9962629 TI - Topological time-series analysis of a string experiment and its synchronized model. PMID- 9962630 TI - Theoretical approach to two-dimensional traffic flow models. PMID- 9962632 TI - Rectangular billiard in the presence of a flux line. PMID- 9962631 TI - Phase-ordering dynamics of systems with a conserved vector order parameter. PMID- 9962633 TI - Gaussian approach for phase ordering in nonconserved scalar systems with long range interactions. PMID- 9962634 TI - Influence of the environment on anomalous diffusion. PMID- 9962635 TI - Third law of thermodynamics in the presence of a heat flux. PMID- 9962636 TI - Phase transitions in the interacting-domain-wall model. PMID- 9962637 TI - Scaling structure and 1/f noise in one-dimensional surface-reaction models. PMID- 9962639 TI - Statistical theory of an adiabatic process. PMID- 9962638 TI - Dynamic algorithm for loop-erased self-avoiding random walks in two and three dimensions. PMID- 9962641 TI - Local thermodynamics of inhomogeneous fluids at equilibrium. PMID- 9962640 TI - Reaction probability derived from an interpolation formula for diffusion processes with an absorptive boundary condition. PMID- 9962642 TI - Determination of the differential cross section for a realistic intermolecular potential. PMID- 9962643 TI - Shear viscosity via global control of spatiotemporal chaos in two-dimensional isoenergetic dense fluids. PMID- 9962644 TI - Numerical solution of the spatially inhomogeneous Boltzmann equation and verification of the nonlocal approach for an argon plasma. PMID- 9962645 TI - Monte Carlo simulation and integral-equation studies of a fluid of charged hard spheres near the critical region. PMID- 9962646 TI - Kinetic model for pair correlations. PMID- 9962647 TI - Steady squares and hexagons on a subcritical ramp. PMID- 9962648 TI - Multiplicative cascade models of multifractal solar magnetic fields. PMID- 9962649 TI - Improved low-order model for shear flow driven by Rayleigh-Benard convection. PMID- 9962650 TI - Description of concentration fluctuations in liquid binary mixtures with nonadditive potentials. PMID- 9962651 TI - Binary fluid convection in a cylinder. PMID- 9962653 TI - Rigorous bound on the plane-shear-flow dissipation rate. PMID- 9962652 TI - Noise-induced sidebranching in the three-dimensional nonaxisymmetric dendritic growth. PMID- 9962654 TI - Saddle-splay elasticity of nematic structures confined to a cylindrical capillary. PMID- 9962656 TI - Higher smectic-layer order parameters in liquid crystals determined by x-ray diffraction and the effect of antiferroelectricity. PMID- 9962655 TI - Fluid elasticity and the transition to chaos in thermal convection. PMID- 9962657 TI - Flory approximant for the fractal dimension of the viscous-finger pattern: Transient and asymptotic behaviors. PMID- 9962658 TI - Annihilation rate and scaling in a two-dimensional system of charged particles. PMID- 9962659 TI - Relation between anchorings of liquid crystals and conformation changes in aligning agents by the Langmuir-Blodgett film technique investigation. PMID- 9962660 TI - Experimental evidence for the divergence of a transport coefficient in a quasi two-dimensional fluid. PMID- 9962661 TI - Universal relaxation behavior of classical liquid crystals at hypersonic frequencies. PMID- 9962662 TI - Molecular-dynamics studies of systems of confined dumbbell molecules. PMID- 9962663 TI - Characterization of 12-8-diacetylene Langmuir-Blodgett films by scanning-force microscopy. PMID- 9962664 TI - Tilt susceptibility at an antiferroelectric smectic-CA*-smectic-A phase transition. PMID- 9962665 TI - Micelle size and orientational order across the nematic-isotropic transition: A field-dependent nuclear-spin-relaxation study. PMID- 9962666 TI - Dielectric relaxation in sodium bis(2-ethylhexyl)sulfosuccinate-water-decane microemulsions near the percolation temperature threshold. PMID- 9962667 TI - Equilibrium properties of polymers from the Langevin equation: Gaussian self consistent approach. PMID- 9962668 TI - Molecular dynamics simulations of polymer droplets. PMID- 9962670 TI - Phase diagram and scaling behavior of fluid vesicles. PMID- 9962669 TI - Phase transitions and modulated phases in lipid bilayers. PMID- 9962671 TI - X-ray reflectivity study of interface roughness, structure, and morphology of alignment layers and thin liquid crystal films. PMID- 9962672 TI - Elasticity theory of smectic and canonic mesophases. PMID- 9962674 TI - Microemulsion and lamellar phases of a vector lattice model. PMID- 9962673 TI - Parametrization invariance and shape equations of elastic axisymmetric vesicles. PMID- 9962675 TI - Isostructural solid-solid transition of (colloidal) simple fluids. PMID- 9962676 TI - Flow birefringence in lyotropic mixtures in the isotropic phase. PMID- 9962677 TI - Free-growth properties of a nematic-smectic-B liquid-crystal interface. PMID- 9962678 TI - Interpenetration and segregation of interacting polymer chains in a solution: Exact results on fractal lattices. PMID- 9962679 TI - Mass conservation and anticorrelation effects in the colloidal aggregation of dense solutions. PMID- 9962680 TI - Magnetic diffusion-limited aggregation. PMID- 9962681 TI - Heterogeneous versus homogeneous nucleation of kink-antikink pairs. PMID- 9962682 TI - Search for ion dynamics effects on the shift and width of plasma-broadened C I and O I spectral lines. PMID- 9962684 TI - Correlated ion stopping in a dense classical plasma. PMID- 9962683 TI - Correlated stopping of Coulomb clusters in a dense jellium target. PMID- 9962685 TI - Effective bandwidth and the Kompfner dip for cyclotron autoresonance maser amplifiers. PMID- 9962686 TI - Electron-beam acceleration by cyclotron-autoresonance interaction. PMID- 9962687 TI - Phenomenological description of the optical field chaos in storage ring free electron lasers. PMID- 9962689 TI - Properties of wave functions in homogeneous anisotropic media. PMID- 9962688 TI - Soliton evolution and radiation loss for the Korteweg-de Vries equation. PMID- 9962691 TI - Propagation of electromagnetic waves in periodic lattices of spheres: Green's function and lattice sums. PMID- 9962690 TI - Nonuniqueness of the Lorentz-Dirac equation with the free-particle asymptotic condition. PMID- 9962692 TI - Numerical investigation of isospectral cavities built from triangles. PMID- 9962693 TI - Soliton interactions on dual-core fibers. PMID- 9962694 TI - Contact force distribution in a pile of rigid disks. PMID- 9962696 TI - Mixture states and storage of biased patterns in the Hopfield model: A replica symmetry-breaking solution. PMID- 9962695 TI - Deformation of an elastic triangle in equilibrium under gravity. PMID- 9962698 TI - Remark on "Some simple chaotic flows" PMID- 9962697 TI - Time structure of the activity in neural network models. PMID- 9962699 TI - Suppression of chaos by selective resonant parametric perturbations. PMID- 9962700 TI - Weak non-Gaussian approximation. PMID- 9962701 TI - Form of uncompensated heat giving rise to a Pfaffian differential form in thermodynamic space. PMID- 9962703 TI - Controlling of chaotic motion by chaos and noise signals in a logistic map and a Bonhoeffer-van der Pol oscillator. PMID- 9962702 TI - Two-dimensional traffic flow problems with faulty traffic lights. PMID- 9962704 TI - Results for the structural properties of random heaps of hard disks. PMID- 9962705 TI - Singularity spectrum of the velocity increment in isotropic turbulence. PMID- 9962707 TI - Variations from the Plateau law in foams. PMID- 9962706 TI - Rigorous analysis of weak boundary-coupling effects in twisted chiral nematic liquid crystals. PMID- 9962708 TI - Magnetic field effect on periodic stripe domains in nematic liquid crystals. PMID- 9962709 TI - Exact derivation of the Kardar-Parisi-Zhang equation for the restricted solid-on solid model. PMID- 9962710 TI - Repulsive forces in thin smectic-C* films on substrates. PMID- 9962712 TI - Comparative study of large-scale Laplacian growth patterns. PMID- 9962711 TI - Scaling of the time-dependent self-diffusion coefficient and the propagation of hydrodynamic interactions. PMID- 9962713 TI - Hydrodynamic approximation for ions in high-pressure rf glow discharges. PMID- 9962715 TI - Modulational instability of two counterpropagating waves in an experimental transmission line. PMID- 9962714 TI - Scaling function for free-electron-laser gain including alternating-gradient focusing. PMID- 9962717 TI - Deriving average soliton equations with a perturbative method. PMID- 9962716 TI - Split-operator technique and solution of Liouville propagation equations. PMID- 9962719 TI - Traveling salesman problem and Tsallis statistics. PMID- 9962718 TI - Fluctuation-dissipation theorem imposes high-voltage fluctuations in biological ionic channels. PMID- 9962720 TI - Dynamics of spin and chiral ordering in the two-dimensional fully frustrated XY model. PMID- 9962722 TI - Surface and bulk periodical structures in smectic-C films with one free boundary. PMID- 9962721 TI - Crossover from static to thermal layer undulations in finite-size liquid crystalline films. PMID- 9962724 TI - Tilted arrays of dendrites. PMID- 9962723 TI - Random successive growth model for pattern formation. PMID- 9962726 TI - Reshaping-induced chaos suppression. PMID- 9962725 TI - False gain in x-ray laser experiments due to axial plasma expansion. PMID- 9962728 TI - Population dependence of early relaxation. PMID- 9962727 TI - Adsorption kinetics of hard disks from virial coefficients. PMID- 9962729 TI - Soluble free-fermion model in d dimensions. PMID- 9962730 TI - Undulatory instability of the nematic-isotropic interface. PMID- 9962731 TI - Relaxation induced by colored noise. II. Homogeneous and heterogeneous correlation loss. PMID- 9962732 TI - Bunching of cars in asymmetric exclusion models for freeway traffic. PMID- 9962733 TI - Continued fraction formalism of linear dynamic conductivity by a combined projection technique. PMID- 9962735 TI - Geometrical description of phase transitions in terms of diagrams and their growth function. PMID- 9962734 TI - Structure in the bifurcation diagram of the Duffing oscillator. PMID- 9962736 TI - Interpretation of the extreme physical information principle in terms of shift information. PMID- 9962738 TI - Numerical solution of the Kardar-Parisi-Zhang equation with a long-range spatially correlated noise. PMID- 9962737 TI - Generalized synchronization of chaos in directionally coupled chaotic systems. PMID- 9962739 TI - Amplification and distortion of a periodic rectangular driving signal by a noisy bistable system. PMID- 9962740 TI - Jordan-Wigner transformation in a higher-dimensional lattice. PMID- 9962742 TI - Crisis and topological entropy. PMID- 9962741 TI - Geometrical aspects of statistical mechanics. PMID- 9962743 TI - Averaged equations for Josephson junction series arrays. PMID- 9962744 TI - Adiabatic destruction of Anderson localization. PMID- 9962745 TI - Correlation decay and conformal anomaly in the two-dimensional random-bond Ising ferromagnet. PMID- 9962746 TI - Dynamical model of traffic congestion and numerical simulation. PMID- 9962747 TI - Shattering transition in a multivariable fragmentation model. PMID- 9962748 TI - Exact solutions of a restricted ballistic deposition model on a one-dimensional staircase. PMID- 9962750 TI - Criticality in simple models of evolution. PMID- 9962749 TI - Model for plastic deformation and fracture in planar disordered materials. PMID- 9962751 TI - Bose-Einstein condensation of a coupled two-component Bose gas. PMID- 9962752 TI - Generalized Stokes-Einstein equation for spherical particle suspensions. PMID- 9962753 TI - Generalized hydrodynamics and the acoustic modes of water: Theory and simulation results. PMID- 9962754 TI - Convective chemical-wave propagation in the Belousov-Zhabotinsky reaction. PMID- 9962755 TI - Statistical studies of chaotic wave patterns. PMID- 9962757 TI - Flow in curved channels with a low negative rotation speed. PMID- 9962756 TI - Breakdown of dynamic scaling and intermittency in a cascade model of turbulence. PMID- 9962758 TI - Faraday instability: Linear analysis for viscous fluids. PMID- 9962759 TI - Two-dimensional pentagonal structures in dissipative systems. PMID- 9962760 TI - Extinction of a nonadiabatic flame propagating through spatially periodic shear flow. PMID- 9962762 TI - Bragg reflection from cholesteric liquid crystals. PMID- 9962761 TI - Pattern selection in an anisotropic Hele-Shaw cell. PMID- 9962764 TI - Kinetics of phase ordering in uniaxial and biaxial nematic films. PMID- 9962763 TI - Crossover between vapor-liquid and consolute critical phenomena. PMID- 9962765 TI - Translational dynamics of a particle with anchored chains in entangled polymers. PMID- 9962766 TI - Intermittent flow behavior of random foams: A computer experiment on foam rheology. PMID- 9962767 TI - Critical-point rheology of a sheared phase-separating micellar solution. PMID- 9962769 TI - Faceting in free dendritic growth. PMID- 9962768 TI - Time-transient process of magnetically induced growth of nematic domains in a biological macromolecular liquid crystal. PMID- 9962770 TI - Experimental examination of the Booth theory on the first-order electroviscous effect in ionic colloidal dispersions. PMID- 9962771 TI - Coupling between elasticity in a nematic phase and front dynamics for a moving nematic-isotropic boundary. PMID- 9962772 TI - Wetting on heterogeneous surfaces: Experiments in an imperfect Hele-Shaw cell. PMID- 9962774 TI - Hydrodynamic interface quench effects on spinodal decomposition for symmetric binary fluid mixtures. PMID- 9962773 TI - Instabilities of charged polyampholytes. PMID- 9962775 TI - Disclination loops, standing alone and around solid particles, in nematic liquid crystals. PMID- 9962776 TI - Velocity fluctuations of fracturelike disruptions of associating polymer solutions. PMID- 9962777 TI - Phase behavior of a model colloid-polymer mixture. PMID- 9962779 TI - Group velocity of large-amplitude electromagnetic waves in a plasma. PMID- 9962778 TI - Percolation and structural properties of particle deposits. PMID- 9962780 TI - Two-dimensional model of a capacitively coupled rf discharge and comparisons with experiments in the Gaseous Electronics Conference reference reactor. PMID- 9962781 TI - Trivelpiece-Gould modes in a corrugated plasma slab. PMID- 9962782 TI - Ion acoustic waves in plasmas with light and heavy ions. PMID- 9962783 TI - Nonlinear waves in cylindrically bounded magnetized plasmas. PMID- 9962784 TI - Field-line transport in stochastic magnetic fields: Percolation, Levy flights, and non-Gaussian dynamics. PMID- 9962785 TI - Absolute determination of local ground-state densities of atomic hydrogen in nonlocal-thermodynamic-equilibrium environments by two-photon polarization spectroscopy. PMID- 9962787 TI - Population kinetics of lithiumlike ions in plasma. PMID- 9962786 TI - Collisional-radiative model for lithiumlike ions in plasma. PMID- 9962788 TI - Experimental study of the response time of GaAs as a photoemitter. PMID- 9962789 TI - Emittance growth of bunched beams in bends. PMID- 9962790 TI - Multisoliton perturbation theory for the Benjamin-Ono equation and its application to real physical systems. PMID- 9962791 TI - Soliton evolution and radiation loss for the nonlinear Schrodinger equation. PMID- 9962792 TI - Traveling-wave method for solving the modified nonlinear Schrodinger equation describing soliton propagation along optical fibers. PMID- 9962794 TI - Existence of localized excitations in nonlinear Hamiltonian lattices. PMID- 9962793 TI - Algebraic solitary-wave solutions of a nonlinear Schrodinger equation. PMID- 9962795 TI - Resonances of nonlinear oscillators. PMID- 9962797 TI - Neural-network model composed of multidimensional spin neurons. PMID- 9962796 TI - Gel electrophoresis of DNA in moderate fields: The effect of fluctuations. PMID- 9962799 TI - Parallel Monte Carlo simulations. PMID- 9962798 TI - Dual Monte Carlo and cluster algorithms. PMID- 9962800 TI - Behavior of ferroelectric liquid crystals in external fields. PMID- 9962801 TI - Statistical mechanics of a multiconnected Hopfield neural-network model in a transverse field. PMID- 9962802 TI - Accuracy of the semiclassical approximation for chaotic scattering. PMID- 9962803 TI - Relativistic chaos in the driven harmonic oscillator. PMID- 9962804 TI - Orbital instability and the loss of quantum coherence. PMID- 9962806 TI - Transitions in a gauge model for nematic ordering. PMID- 9962805 TI - Structure formation in a colloidal suspension film subjected to an external alternating electrical field. PMID- 9962807 TI - Unusual shapes for a catenary under the effects of surface tension and gravity: A variational treatment. PMID- 9962808 TI - Structural transition and motion of domain walls in liquid crystals under a rotating magnetic field. PMID- 9962809 TI - Relation between the super-transition-array method in opacity calculations and the Hartree-Fock approximation at nonzero temperature. PMID- 9962811 TI - Envelope Hamiltonian of an intense charged-particle beam in periodic solenoidal fields. PMID- 9962810 TI - Signature of chaos in nonlinear drift-wave-induced transport. PMID- 9962813 TI - Path-integral evolution of multivariate systems with moderate noise. PMID- 9962812 TI - Gap solitons due to cascading. PMID- 9962814 TI - Erratum: Stopping of multicharged ions in dense and fully ionized hydrogen PMID- 9962816 TI - Domains and synchronization in high-dimensional cellular automata. PMID- 9962815 TI - Random versus deterministic two-dimensional traffic flow models. PMID- 9962817 TI - Correlations in the quantum spectra of smooth Hamiltonian systems. PMID- 9962818 TI - -shaped stable nonspiral patterns. PMID- 9962820 TI - Two-dimensional localized solutions for subcritical bifurcations in systems with broken rotational symmetry. PMID- 9962819 TI - Fractional master equations and fractal time random walks. PMID- 9962821 TI - Self-similar decay of three-dimensional homogeneous turbulence with hyperviscosity. PMID- 9962822 TI - Theory of chiral defects in Langmuir monolayers. PMID- 9962823 TI - Bound solitons in a nonlinear optical coupler. PMID- 9962825 TI - Possible thermodynamic law violations and astrophysical issues for secular acceleration of electrodynamic particles in the vacuum. PMID- 9962824 TI - Faster Monte Carlo simulations. PMID- 9962827 TI - Driven interfaces in quenched disorder at critical depinning. PMID- 9962826 TI - Aperture of rough cracks. PMID- 9962828 TI - Control in multidimensional chaotic systems by small perturbations. PMID- 9962829 TI - Generalized Allen-Cahn equations to describe far-from-equilibrium order-disorder dynamics. PMID- 9962830 TI - Renormalization approach to the self-organized critical behavior of sandpile models. PMID- 9962831 TI - Virial expansions for quantum plasmas: Maxwell-Boltzmann statistics. PMID- 9962832 TI - Density waves and 1/f density fluctuations in granular flow. PMID- 9962833 TI - Large-time behavior of the generalized Smoluchovski coagulation equations. PMID- 9962834 TI - Correlation properties of a quasiperiodically forced two-level system. PMID- 9962835 TI - Development of quantum nonintegrability displayed in effective Hamiltonians: A three-level Lipkin model. PMID- 9962837 TI - Self-avoiding-walk contacts and random-walk self-intersections in variable dimensionality. PMID- 9962836 TI - Learning time series evolution by unsupervised extraction of correlations. PMID- 9962838 TI - Laminar-localized-phase coexistence in dynamical systems. PMID- 9962839 TI - Quantum-classical correspondence and the transition to chaos in coupled quartic oscillators. PMID- 9962840 TI - Bifurcations and complete chaos for the diamagnetic Kepler problem. PMID- 9962842 TI - Inhibition of mixing in chaotic quantum dynamics. PMID- 9962841 TI - Tracking unstable periodic orbits in a bronze ribbon experiment. PMID- 9962844 TI - Bifurcation analysis of two coupled periodically driven Duffing oscillators. PMID- 9962843 TI - Asymptotic behavior of A+B--> inert for particles with a drift. PMID- 9962845 TI - Transition-state recrossing dynamics in activated rate processes. PMID- 9962847 TI - Dynamical universality of the nonlinear conserved current equation for growing interfaces. PMID- 9962848 TI - Critical exponents for a three-dimensional O(n)-symmetric model with n>3. PMID- 9962849 TI - Lamellar structures and self-replicating spots in a reaction-diffusion system. PMID- 9962846 TI - Surface properties and the flow of granular material in a two-dimensional rotating-drum model. PMID- 9962851 TI - Dynamical origin of spatial order. PMID- 9962850 TI - Dynamical phase transitions and self-organized criticality in a theoretical spring-block model. PMID- 9962852 TI - Driven particle in an infinite square well: Representation and breakdown of the invariant tori in a multiple-resonance case. PMID- 9962853 TI - Wavelet correlations in the p model. PMID- 9962854 TI - Simulations of pressure fluctuations and acoustic emission in hydraulic fracturing. PMID- 9962855 TI - Chaos and low-order corrections to classical mechanics or geometrical optics. PMID- 9962856 TI - Symbolic dynamics analysis of topological entropy and its multifractal structure. PMID- 9962857 TI - Global metric regularity of the devil's staircase of topological entropy. PMID- 9962858 TI - Decay of the false vacuum through dissipative tunneling. PMID- 9962859 TI - Sequence of constrained annealed averages for one-dimensional disordered systems. PMID- 9962860 TI - Thermal relaxation of supercritical fluids by equilibrium molecular dynamics. PMID- 9962861 TI - Kinetic roughening in deposition with suppressed screening. PMID- 9962862 TI - Mass dependence of isotope self-diffusion by molecular dynamics. PMID- 9962863 TI - Statistical properties of the heat transport in a model of rotating Benard convection. PMID- 9962864 TI - Pattern selection in the generalized Swift-Hohenberg model. PMID- 9962865 TI - Wetting on lines and lattices of cylinders. PMID- 9962866 TI - Complex Trkalian fields and solutions to Euler's equations for the ideal fluid. PMID- 9962867 TI - X-ray transmission technique to study carbon dioxide in the critical region. PMID- 9962868 TI - Concentration and energy fluctuations in a critical polymer mixture. PMID- 9962869 TI - Calculation of monolayer structures of hydrocarbon chains on transition metal dichalcogenides: Dotriacontane on MoSe2. PMID- 9962870 TI - Field-induced forces in colloidal particle chains. PMID- 9962871 TI - Scaling of spin-echo amplitudes with frequency, diffusion coefficient, pore size, and susceptibility difference for the NMR of fluids in porous media and biological tissues. PMID- 9962872 TI - Second-order elasticity of liquid crystals within their nematic state at high frequencies. PMID- 9962873 TI - Electric-field-induced optical rotation in the pretransitional isotropic region of chiral nematic liquid crystals. PMID- 9962874 TI - Dynamics of confined liquids under shear. PMID- 9962875 TI - Models of polymer collapse in three dimensions: Evidence from kinetic growth simulations. PMID- 9962876 TI - Self-diffusion in networks of CPClO3 wormlike micelles. PMID- 9962877 TI - Heat-capacity study of nematic-isotropic and nematic-smectic-A transitions for octylcyanobiphenyl in silica aerogels. PMID- 9962878 TI - Orientation of alkyl chains and hindered rotation of carbonyl groups in the smectic-C* phase of antiferroelectric liquid crystals studied by polarized Fourier transform infrared spectroscopy. PMID- 9962879 TI - Chiral nematic droplets with tangential anchoring and negative dielectric anisotropy in an electric field. PMID- 9962880 TI - Relaxation dynamics in suspensions of ferromagnetic particles. PMID- 9962881 TI - Mechanisms of fluid spreading: Ising model simulations. PMID- 9962882 TI - Viscosity coefficients of partially aligned nematic and nematic discotic liquid crystals. PMID- 9962883 TI - Branched polymers on Bethe and Husimi lattices. PMID- 9962884 TI - Investigating the nematic-smectic-A transition by capillary-length measurements near an apparent tricritical point. PMID- 9962885 TI - Symmetry and phase transitions in Langmuir monolayers: The Landau theory. PMID- 9962887 TI - Percus-Yevick approximation for fluids with spontaneous partial order. PMID- 9962886 TI - Absence of anomalous dispersion features in the inelastic neutron scattering spectra of water at both sides of the melting transition. PMID- 9962888 TI - Stretch transition in a polymer brush. PMID- 9962889 TI - Anomalous relaxation in fractal structures. PMID- 9962890 TI - Complete unbinding of fluid membranes in the presence of short-ranged forces. PMID- 9962892 TI - Small-angle neutron-scattering study of micellar structure and interparticle interactions in Triton X-100 solutions. PMID- 9962891 TI - Microscopic theory of binary mixtures of uniaxial nematic liquid crystals. PMID- 9962894 TI - Hydrodynamical modes and light scattering in the liquid-crystalline cubic blue phases. II. Dynamic theory. PMID- 9962893 TI - Hydrodynamical modes and light scattering in the liquid-crystalline cubic blue phases. I. Elastic theory. PMID- 9962895 TI - Light-scattering studies on water-nonionic-amphiphile solutions. PMID- 9962896 TI - Rotational dynamics of water molecules in a water-short-chain-nonionic-amphiphile mixture: Depolarized light scattering. PMID- 9962897 TI - Stabilizing effect of elasticity is not enough to resolve discrepancies in observations concerning a moving nematic-isotropic interface. PMID- 9962898 TI - Apparent rate constant for diffusion-controlled three-molecule reactions. PMID- 9962899 TI - Development of a plasma waveguide for high-intensity laser pulses. PMID- 9962900 TI - Modulational processes and limits of weak turbulence theory. PMID- 9962901 TI - Arbitrary-amplitude electrostatic traveling structures in a plasma. PMID- 9962902 TI - Dispersion relation and the dieletric tensor for magnetized plasmas with inhomogeneous magnetic field. PMID- 9962903 TI - Negative ions in a radio-frequency oxygen plasma. PMID- 9962905 TI - Convective growth of cyclotron harmonic waves on a bounded coaxial electron beam. PMID- 9962904 TI - Charged-species profiles in electronegative radio-frequency plasmas. PMID- 9962907 TI - Local dispersion insert for particle accelerators. PMID- 9962906 TI - Energy limit in cyclotron autoresonance acceleration. PMID- 9962908 TI - Three-dimensional coupled-mode theory of free-electron lasers in the collective regime. PMID- 9962910 TI - Symplectic tracking using point magnets and a reference orbit made of circular arcs and straight lines. PMID- 9962909 TI - Acoustic laser with dispersed particles as an analog of a free-electron laser. PMID- 9962911 TI - Coherent bremsstrahlung at the B factories SLAC PEP-II and KEK Tristan-B. PMID- 9962912 TI - Trapped modes in waveguides with many small discontinuities. PMID- 9962913 TI - Quantum mechanics of charged-particle beam transport through magnetic lenses. PMID- 9962914 TI - Application of Gegenbauer analysis to light scattering from spheres: Theory. PMID- 9962915 TI - Pulse switching in nonlinear fiber directional couplers. PMID- 9962917 TI - Floquet-Bloch waves in periodic chiral media. PMID- 9962916 TI - Minimal model for avalanches in granular systems. PMID- 9962919 TI - Quasiperiodic solutions of discretized Korteweg-de Vries equations. PMID- 9962918 TI - Boundary-value problems of enhanced backscattering in a random medium and the inner structure of the Bethe-Salpeter equation. PMID- 9962921 TI - Order-parameter flow in symmetric and nonsymmetric fully connected attractor neural networks near saturation. PMID- 9962920 TI - Momentum-dependent potentials: Towards the molecular dynamics of fermionlike classical particles. PMID- 9962922 TI - Scaling regimes of molecular size and self-entanglements in very compact proteins. PMID- 9962923 TI - Qualitative analysis of Cohen-Grossberg neural networks with multiple delays. PMID- 9962924 TI - Dynamics of associative memory with a general transfer function. PMID- 9962925 TI - Time-frequency analysis of electroencephalogram series. PMID- 9962926 TI - Mass distribution on clusters at the percolation threshold. PMID- 9962927 TI - Hard-spin mean-field theory of a three-dimensional stacked-triangular-lattice system. PMID- 9962928 TI - Suppression of higher harmonics at noise induced resonances. PMID- 9962929 TI - Self-avoiding walks including next-nearest-neighbor steps. PMID- 9962931 TI - Data compressibility, physical entropy, and evolutionary a priori relation between observer and object. PMID- 9962930 TI - Exact distributions of eigenvalue curvatures for time-reversal-invariant chaotic systems. PMID- 9962932 TI - Dynamics of liquid and strongly supercooled alkali metals by instantaneous normal mode analysis. PMID- 9962933 TI - Confined semiflexible polymer chains. PMID- 9962934 TI - Alfven current drive in magnetic traps. PMID- 9962935 TI - Reconstructing phylogeny from the multifractal spectrum of mitochondrial DNA. PMID- 9962936 TI - Comment on "Extended self-similarity in turbulent flows" PMID- 9962938 TI - Comment on "Surface critical exponents of self-avoiding walks on a square lattice with an adsorbing linear boundary: A computer simulation study" PMID- 9962937 TI - Reply to "Comment on 'Extended self-similarity in turbulent flows' " PMID- 9962939 TI - Reply to "Comment on 'Surface critical exponents of self-avoiding walks on a square lattice with an adsorbing linear boundary: A computer simulation study' " PMID- 9962940 TI - Erratum: Fault-tolerant sensor integration using multiresolution decomposition PMID- 9962941 TI - Stabilized spatiotemporal waves in a convectively unstable open flow system: coupled diode resonators. PMID- 9962943 TI - Exact exponent lambda of the autocorrelation function for a soluble model of coarsening. PMID- 9962944 TI - Analysis of self-averaging properties in the transport of particles through random media. PMID- 9962942 TI - Birth of a strange nonchaotic attractor: A renormalization group analysis. PMID- 9962946 TI - Numerical test of finite-barrier corrections for the hopping rate in the underdamped regime. PMID- 9962945 TI - Phase ordering of two-dimensional XY systems below the Kosterlitz-Thouless transition temperature. PMID- 9962948 TI - Mean-field phase diagram of a coupled XY-Ising model for discotic liquid crystals. PMID- 9962947 TI - Cavitation in a flowing liquid. PMID- 9962949 TI - alpha -particle transport-driven current in tokamaks. PMID- 9962950 TI - Stable spatially periodic patterns of ion channels in biomembranes. PMID- 9962951 TI - Periodic solutions and bifurcation behavior in the parametrically damped two-well Duffing equation. PMID- 9962953 TI - Reaction rate kernel for dichotomous noise-induced transitions in bistable systems. PMID- 9962952 TI - Random walks on a fluctuating lattice: A renormalization group approach applied in one dimension. PMID- 9962955 TI - Absorbing boundary in one-dimensional anomalous transport. PMID- 9962954 TI - Mechanism of time-delayed fractures. PMID- 9962956 TI - Diffusion coefficient of piecewise linear maps. PMID- 9962957 TI - Thin Ising films with competing walls: A Monte Carlo study. PMID- 9962958 TI - Depletion region for diffusion-controlled reactions in a field. PMID- 9962960 TI - Quantum fluctuations of flexible chain molecules and rods and molecular nanotechnology. PMID- 9962959 TI - Estimation of Lyapunov exponents of dynamical systems using a spatial average. PMID- 9962961 TI - Spectral dimension of fractal trees. PMID- 9962962 TI - Homoclinic chaos in the discrete self-trapping trimer. PMID- 9962963 TI - Energy transitions and time scales to equipartition in the Fermi-Pasta-Ulam oscillator chain. PMID- 9962965 TI - Scaling of thermal hysteresis with temperature scanning rate. PMID- 9962964 TI - Growth kinetics for a system with a conserved order parameter: Off-critical quenches. PMID- 9962967 TI - Emergent traffic jams. PMID- 9962966 TI - Unpredictability of the asymptotic attractors in phase-coupled oscillators. PMID- 9962968 TI - Long-range-interaction models and a deformed-loop symmetry. PMID- 9962969 TI - Semiquantal corrections to stochastic resonance. PMID- 9962970 TI - Non-Markovian process driven by quadratic noise: Kramers-Moyal expansion and Fokker-Planck modeling. PMID- 9962971 TI - Discrete stochastic models for traffic flow. PMID- 9962972 TI - Method of false nearest neighbors: A cautionary note. PMID- 9962973 TI - Controlling chaos using time delay coordinates via stabilization of periodic orbits. PMID- 9962974 TI - Synchronization of chaotic resonators based on control theory. PMID- 9962975 TI - Use of Hamiltonian mechanics in systems driven by colored noise. PMID- 9962977 TI - Free inertial processes driven by Gaussian noise: Probability distributions, anomalous diffusion, and fractal behavior. PMID- 9962976 TI - Dissipative transfer of a quantum particle in a dimer with random fluctuating intersite matrix element. PMID- 9962979 TI - From dynamics to thermodynamics: Linear response and statistical mechanics. PMID- 9962978 TI - Decay of the Sinai well in D dimensions. PMID- 9962980 TI - Chaos in a Coulombic muffin-tin potential. PMID- 9962982 TI - Nonperturbative generalized master equation for the spin-boson problem. PMID- 9962981 TI - Role of initial conditions in the classification of the rule space of cellular automata dynamics. PMID- 9962983 TI - Cellular automaton model for diffusive and dissipative systems. PMID- 9962984 TI - Dynamic front transitions and spiral-vortex nucleation. PMID- 9962985 TI - Intrinsic-noise-induced transitions in chaotic systems. PMID- 9962986 TI - Crossover behaviors in a molecular-beam epitaxial-growth model. PMID- 9962988 TI - Linear processes that produce 1/f or flicker noise. PMID- 9962989 TI - Stochastic renormalization-group approach to space-dependent supercritical branched chain processes. PMID- 9962987 TI - Critical behavior of the random-bond Ashkin-Teller model: A Monte Carlo study. PMID- 9962991 TI - Microscopic dynamics in liquid lithium. PMID- 9962990 TI - Jump clustering, Shlesinger-Hughes stochastic renormalization, and interacting Levy flights. PMID- 9962992 TI - Exact results in a lattice model of a binary reactant mixture. PMID- 9962993 TI - Location of the Fisher-Widom line for systems interacting through short-ranged potentials. PMID- 9962994 TI - Heat transport in a dilute gas under uniform shear flow. PMID- 9962995 TI - Improved fluid-dynamic model for vehicular traffic. PMID- 9962996 TI - Nearest-neighbor statistics for packings of hard spheres and disks. PMID- 9962998 TI - Variational bounds on energy dissipation in incompressible flows. II. Channel flow. PMID- 9962997 TI - Numerical simulations of Kadomtsev-Petviashvili soliton interactions. PMID- 9962999 TI - Spatiotemporal response described by the resonantly forced modified Korteweg-de Vries equation. PMID- 9963000 TI - Creation and dynamics of vortex tubes in three-dimensional turbulence. PMID- 9963001 TI - Density equilibration near the liquid-vapor critical point of a pure fluid: Single phase T>Tc. PMID- 9963003 TI - NMR signal loss from turbulence: Models of time dependence compared with data. PMID- 9963002 TI - Effect of a time-periodic axial shear flow upon the onset of Taylor vortices. PMID- 9963004 TI - Convection for Prandtl numbers near 1: Dynamics of textured patterns. PMID- 9963005 TI - Front propagation and selection in a two-space diblock copolymer melt. PMID- 9963006 TI - Scaling of single-bubble growth in a porous medium. PMID- 9963007 TI - "Layering" effect in a sheared lyotropic lamellar phase. PMID- 9963009 TI - Diffusion constants in polyacrylamide gels. PMID- 9963008 TI - Morphology and line tension of liquid films adsorbed on chemically structured substrates. PMID- 9963010 TI - Preferred configurations of linear polymers embedded in planar membranes under lateral tension. PMID- 9963012 TI - Computer simulation study of the permeability of a porous sediment model. PMID- 9963011 TI - Deuteron NMR study of liquid crystals confined in aerogel matrices. PMID- 9963014 TI - Accuracy of diffusing-wave spectroscopy theories. PMID- 9963013 TI - ac-calorimetry studies at the hexatic-B-smectic-A and crystal-B-hexatic-B phase transitions in two compounds with hydrogen bonding. PMID- 9963015 TI - Incommensurate phase on a disordered surface: Instability against the formation of overhangs and finite loops. PMID- 9963016 TI - Dynamic heat capacity at the gel to liquid-crystalline phase transition in large unilamellar vesicles of dimyristoylphosphatidylcholine in the ultralow frequency region. PMID- 9963017 TI - Surface polymer network model and effective membrane curvature elasticity. PMID- 9963018 TI - Maximal Lyapunov exponent in small atomic clusters. PMID- 9963019 TI - Freezing transition of random heteropolymers consisting of an arbitrary set of monomers. PMID- 9963020 TI - Self-diffusion in a periodic porous medium: A comparison of different approaches. PMID- 9963021 TI - Self-diffusion in a periodic porous medium with interface absorption. PMID- 9963022 TI - Catalytic interface erosion. PMID- 9963024 TI - Two-dimensional Laplacian growth as a system of creating and annihilating particles. PMID- 9963023 TI - Spreading of giant vesicles on moderately adhesive substrates by fingering: A reflection interference contrast microscopy study. PMID- 9963025 TI - Role of convection in thin-layer electrodeposition. PMID- 9963026 TI - Atoms in hydrogen plasma in strong electric fields. PMID- 9963027 TI - Spectroscopic study of molecular-hydrogen processes in a mirror-confined plasma. PMID- 9963029 TI - Signatures of the Bohm and sheath velocities in minority-light-ion energy distributions. PMID- 9963028 TI - Multistability as an indication of chaos in a discharge plasma. PMID- 9963030 TI - Resonantly laser-driven plasma waves for electron acceleration. PMID- 9963031 TI - Electron distribution function in an electron-beam plasma. PMID- 9963033 TI - Unified nonlinear orbit dynamics of an equilibrium electron in a helical wiggler with a positive or reversed axial-guide magnetic field at magnetoresonance. PMID- 9963032 TI - Stripping properties of a plasma medium for MeV/u chlorine ions. PMID- 9963035 TI - Computer simulation of beam steering by crystal channeling. PMID- 9963034 TI - Coupling impedance of a long slot and an array of slots in a circular vacuum chamber. PMID- 9963036 TI - Hamiltonian formalism for space charge dominated beams in a uniform focusing channel. PMID- 9963038 TI - Optical phenomena on the interface between a conventional dielectric and a uniaxial medium with mixed metal-dielectric properties. PMID- 9963037 TI - Stationary solitonlike pulses in birefringent optical fibers. PMID- 9963039 TI - Dynamics of damped coupled oscillators near resonance. PMID- 9963040 TI - Stability criterion for stationary bound states of solitons with radiationless oscillating tails. PMID- 9963041 TI - Obtaining breathers in nonlinear Hamiltonian lattices. PMID- 9963042 TI - Solitons in cell membranes. PMID- 9963044 TI - Neural-network design applied to protein-secondary-structure predictions. PMID- 9963043 TI - Statistical physics estimates for the complexity of feedforward neural networks. PMID- 9963045 TI - Finite-dimensional neural networks storing structured patterns. PMID- 9963046 TI - Matrix spectroscopy: Computation of interior eigenstates of large matrices using layered iteration. PMID- 9963047 TI - Flow in the driven cavity calculated by the lattice Boltzmann method. PMID- 9963048 TI - Logistic map: A possible random-number generator. PMID- 9963049 TI - Finite population-size effects in projection Monte Carlo methods. PMID- 9963050 TI - Transport of sputtered neutral particles. PMID- 9963051 TI - Adaptive multigrid techniques for large-scale eigenvalue problems: Solutions of the Schrodinger problem in two and three dimensions. PMID- 9963052 TI - Two-color nonlinear Boltzmann cellular automata: Surface tension and wetting. PMID- 9963053 TI - Boson-fermion transmutation and the statistics of anyons. PMID- 9963054 TI - Kinetics of depolymerization. PMID- 9963056 TI - Anomalous convergence of Lyapunov exponent estimates. PMID- 9963055 TI - Symbolic dynamics of NMR-laser chaos. PMID- 9963057 TI - Mass multifractality in fragmentation. PMID- 9963058 TI - Classical closure theory and Lam's interpretation of epsilon -renormalization group theory. PMID- 9963059 TI - Film orientational correlations from random planar sections. PMID- 9963061 TI - Two-body contribution to the density fluctuations in a dilute gas from molecular dynamics simulations. PMID- 9963060 TI - Two-dimensional stimulated Raman scattering of short laser pulses. PMID- 9963062 TI - Dynamics of collisional pulsed planar sheaths. PMID- 9963064 TI - Generation conditions for an acoustic laser. PMID- 9963063 TI - Calibration of the Stark-broadening parameters of the 728.1-nm He I line. PMID- 9963065 TI - Structural correlations in Gaussian random wave fields. PMID- 9963066 TI - Kinks and conformational defects in nonlinear chains. PMID- 9963068 TI - Comment on "Critical dimensionalities of phase transitions on fractals" PMID- 9963067 TI - Geometric and diffractive orbits in the scattering from confocal hyperbolas. PMID- 9963069 TI - Comment on "Simulation of a two-dimensional Rayleigh-Benard system using the direct simulation Monte Carlo method" PMID- 9963070 TI - Reply to "Comment on 'Simulation of a two-dimensional Rayleigh-Benard system using the direct simulation Monte Carlo method' " PMID- 9963071 TI - Erratum: Short-range screening potentials for classical Coulomb fluids: Monte Carlo sampling and cluster model studies PMID- 9963072 TI - Adaptive control and tracking of chaos in a magnetoelastic ribbon. PMID- 9963073 TI - Effects of the chaotic noise on the performance of a neural network model for optimization problems. PMID- 9963074 TI - Controlling dynamical behavior of a semiconductor laser with external optical feedback. PMID- 9963075 TI - Targeting unstable periodic orbits. PMID- 9963076 TI - Breakdown of simple scaling in Abelian sandpile models in one dimension. PMID- 9963078 TI - Design of hyperchaotic flows. PMID- 9963077 TI - Predicting low-dimensional spatiotemporal dynamics using discrete wavelet transforms. PMID- 9963079 TI - Scaling violations with textures in two-dimensional phase ordering. PMID- 9963080 TI - "Level curvature" distribution for diffusive Aharonov-Bohm systems: Analytical results. PMID- 9963081 TI - Near-equilibrium dynamics of crystalline interfaces with long-range interactions in (1+1)-dimensional systems. PMID- 9963083 TI - General approach to diffusion of periodically kicked charges in a magnetic field. PMID- 9963082 TI - Dissipative dynamic fracture of disordered systems. PMID- 9963084 TI - beta relaxation in a highly supercooled state via molecular dynamics simulation. PMID- 9963085 TI - Kolmogorov turbulence in a random-force-driven Burgers equation. PMID- 9963086 TI - Numerical study of cylindrically confined nematic liquid crystals. PMID- 9963087 TI - Critical broadening of the vibrational linewidth by concentration fluctuations. PMID- 9963088 TI - Eutectic dynamics: A host of new states. PMID- 9963089 TI - Stopping power of nonmonochromatic heavy-ion clusters with two-ion correlation effects. PMID- 9963090 TI - Polarized angular distributions of parametric x radiation and vacuum-ultraviolet transition radiation from relativistic electrons. PMID- 9963091 TI - Analytical approach to localization of electromagnetic waves in two-dimensional random media. PMID- 9963092 TI - Fractal growth in uv-irradiated DNA: Evidence of nonuniversal diffusion limited aggregation. PMID- 9963093 TI - Prediction of the lowest energy structure of clusters using a genetic algorithm. PMID- 9963094 TI - Selection of a desirable chaotic phase using small feedback control. PMID- 9963095 TI - Escape from a fluctuating double well. PMID- 9963096 TI - Polymer-chain adsorption transition at a cylindrical boundary. PMID- 9963098 TI - Analysis of spatiotemporal signals of complex systems. PMID- 9963097 TI - Symbol sequence statistics in noisy chaotic signal reconstruction. PMID- 9963099 TI - Scaling properties and anomalous transport of particles inside the stochastic layer. PMID- 9963101 TI - Avalanches and bursts in low-pressure helium gas below the breakdown voltage. PMID- 9963100 TI - Estimating perturbative coefficients in quantum field theory and statistical physics. PMID- 9963103 TI - Percolation with a periodic boundary condition: The effect of system size for crystallization in molecular dynamics. PMID- 9963102 TI - Statistical properties of bidimensional patterns generated from delayed and extended maps. PMID- 9963104 TI - First return map of the periodic Lorentz gas. PMID- 9963105 TI - Density relaxation in a vibrated granular material. PMID- 9963106 TI - Stochastic resonance in bistable systems subject to signal and quasimonochromatic noise. PMID- 9963108 TI - Ballistic annihilation kinetics: The case of discrete velocity distributions. PMID- 9963107 TI - Avalanches in a cellular automaton. PMID- 9963109 TI - Stabilizing and characterizing unstable states in high-dimensional systems from time series. PMID- 9963111 TI - Nonlinear analysis of the stick-slip bifurcation in the creep-controlled regime of dry friction. PMID- 9963110 TI - Accelerating fronts in an electrochemical system due to global coupling. PMID- 9963112 TI - Correlation functions and spectra for fields with highly anticorrelated phase jumps. PMID- 9963113 TI - Coherent stochastic resonance. PMID- 9963114 TI - Entropy-driven transition in a one-dimensional system. PMID- 9963116 TI - Refined simulations of the reaction front for diffusion-limited two-species annihilation in one dimension. PMID- 9963115 TI - Stochastic dynamics of open quantum systems: Derivation of the differential Chapman-Kolmogorov equation. PMID- 9963118 TI - Fractal boundaries in open hydrodynamical flows: Signatures of chaotic saddles. PMID- 9963117 TI - Parametric entrainment control of chaotic systems. PMID- 9963119 TI - Fluctuations in discrete fragmentation processes studied by stochastic simulations. PMID- 9963120 TI - Field theory and second renormalization group for multifractals in percolation. PMID- 9963121 TI - Escape rates for noisy maps. PMID- 9963122 TI - Schrodinger problem, Levy processes, and noise in relativistic quantum mechanics. PMID- 9963123 TI - Systematic error of dimension estimates using fixed mass scaling methods. PMID- 9963125 TI - Generalized Kawasaki dynamics of the Heisenberg model. PMID- 9963124 TI - Transport properties of heterogeneous materials derived from Gaussian random fields: Bounds and simulation. PMID- 9963126 TI - Stochastic resonance in a system of ferromagnetic particles. PMID- 9963127 TI - Topological model of homoclinic chaos in a glow discharge. PMID- 9963128 TI - Efficient switching between controlled unstable periodic orbits in higher dimensional chaotic systems. PMID- 9963130 TI - Extension of the variational formulation of the Onsager-Machlup theory of fluctuations. PMID- 9963129 TI - Subtleties of arithmetical quantum chaos. PMID- 9963132 TI - Exact results for a model of interface growth. PMID- 9963131 TI - Phase separation of crystal surfaces: A lattice gas approach. PMID- 9963133 TI - Inside-outside duality for planar billiards: A numerical study. PMID- 9963135 TI - Effective action method for the Langevin equation. PMID- 9963136 TI - Memory effects and virial corrections in nonequilibrium dense systems. PMID- 9963134 TI - Flame propagation in random media. PMID- 9963137 TI - Global vector field reconstruction from a chaotic experimental signal in copper electrodissolution. PMID- 9963138 TI - Dissipative quantum systems with a potential barrier: General theory and the parabolic barrier. PMID- 9963139 TI - Social force model for pedestrian dynamics. PMID- 9963140 TI - Non-Boltzmann behavior from the Boltzmann equation. PMID- 9963141 TI - Fluctuation of the number of particles adsorbed on surfaces under the influence of gravity. PMID- 9963142 TI - Einstein-Kubo-Helfand and McQuarrie relations for transport coefficients. PMID- 9963143 TI - Pressure tensor of the hard-disk Lorentz gas. PMID- 9963144 TI - Field-theoretic approximations for normal diffusion in random velocity fields. PMID- 9963145 TI - State diagram of polydisperse elastic-disk systems. PMID- 9963146 TI - Density profiles in a diphasic lattice-gas model. PMID- 9963147 TI - Numerical evaluation of the permeability and the Kozeny constant for two types of porous media. PMID- 9963148 TI - Rupture and coalescence in two-dimensional cellular automata fluids. PMID- 9963150 TI - Burgers turbulence with random forcing: Similarity functional solution of the Hopf equation. PMID- 9963149 TI - Heat flux vector in highly inhomogeneous nonequilibrium fluids. PMID- 9963151 TI - Mode resonance and wavelength-halving instability in the Taylor-Dean system. PMID- 9963152 TI - Quasi-one-component theory of homogeneous binary nucleation. PMID- 9963153 TI - Sonoluminescing bubbles and mass diffusion. PMID- 9963154 TI - Dynamics of defects in parametrically excited capillary ripples. PMID- 9963155 TI - Shallow water waves on the rotating sphere. PMID- 9963156 TI - Statistical mechanics of point vortices. PMID- 9963157 TI - Probability distribution function for the gradient of a passive scalar diffusing in isotropic turbulence: Mapping-closure model. PMID- 9963158 TI - Langevin approach to a chemical wave front: Selection of the propagation velocity in the presence of internal noise. PMID- 9963159 TI - General relation for stationary probability density functions. PMID- 9963161 TI - Instability of two-dimensional solitons and vortices in defocusing media. PMID- 9963162 TI - Growth shapes and turbulent spots in unstable systems. PMID- 9963160 TI - Dynamics of viscous fingers and threshold instability. PMID- 9963163 TI - Density functional theory of ordering in charge-stabilized colloidal dispersions. PMID- 9963164 TI - Macroscopic theory for the flow behavior of smectic-C and smectic-C* liquid crystals. PMID- 9963165 TI - Fluctuation analysis of tension-controlled undulation forces between giant vesicles and solid substrates. PMID- 9963167 TI - Isotropic-nematic interface of liquid-crystalline polymers. PMID- 9963166 TI - Depolarized light-scattering study of molten zinc chloride. PMID- 9963169 TI - Inclusion of density variation in the Landau-de Gennes theory of the nematic isotropic phase transition. PMID- 9963170 TI - Smectic-A surface order in a nematic-substrate system. PMID- 9963168 TI - Single-particle dynamics of water molecules in confined space. PMID- 9963172 TI - Smectic-C-smectic-I critical point in a liquid crystal mixture: Static and dynamic thermal behavior. PMID- 9963171 TI - Desorption-induced fragmentation of silica aggregates. PMID- 9963174 TI - Weakly nonlinear morphological instability of a spherical crystal growing from a pure undercooled melt. PMID- 9963173 TI - Ion correlations in a micellar solution studied by small-angle neutron and x-ray scattering. PMID- 9963175 TI - Axisymmetrical rotation of a sand heap. PMID- 9963176 TI - Testing mode-coupling theory for a supercooled binary Lennard-Jones mixture I: The van Hove correlation function. PMID- 9963177 TI - Nucleation of wetting layers. PMID- 9963178 TI - Avalanches and the directed percolation depinning model: Experiments, simulations, and theory. PMID- 9963180 TI - Dynamics of premelted films: Frost heave in a capillary. PMID- 9963179 TI - Crystalline fluidized beds. PMID- 9963181 TI - Microemulsion model with oil-water anisotropy. PMID- 9963182 TI - Light-scattering study of phase transitions in hexatic liquid-crystal films. PMID- 9963183 TI - How shear flow of a semidilute suspension modifies its self-mobility. PMID- 9963184 TI - X-ray reflectivity measurements and Landau theory of smectic wetting in liquid crystal-benzyl alcohol mixtures. PMID- 9963185 TI - Critical compositions in the microphase separation transition of random copolymers. PMID- 9963186 TI - Membrane curvature studied using two-dimensional NMR in fluid lipid bilayers. PMID- 9963187 TI - Two-dimensional exchange 2H NMR experiments of phospholipid bilayers on a spherical solid support. PMID- 9963188 TI - Symmetry-broken double fingers and seaweed patterns in thin-film directional solidification of a nonfaceted cubic crystal. PMID- 9963189 TI - Diffusion-limited annihilation with initially separated reactants. PMID- 9963190 TI - Inverse bremsstrahlung in strong radiation fields at low temperatures. PMID- 9963191 TI - Nonlinear oblique modulation of ion-acoustic waves in a multicomponent plasma with negative ions. PMID- 9963192 TI - Higher-order contributions to ion-acoustic solitary waves in a multicomponent plasma consisting of warm ions and two-component nonisothermal electrons. PMID- 9963193 TI - Structure of O2- in dense helium gas. PMID- 9963194 TI - Anomalous transport in turbulent plasmas and continuous time random walks. PMID- 9963195 TI - Increased kilo-electron-volt x-ray yields from Z-pinch plasmas by mixing elements of similar atomic numbers. PMID- 9963196 TI - Nonlinear ponderomotive scattering of relativistic electrons by an intense laser field at focus. PMID- 9963197 TI - Diffusive processes in a stochastic magnetic field. PMID- 9963198 TI - Envelope evolution of a laser pulse in an active medium. PMID- 9963199 TI - Pressure ionization in the spherical ion-cell model of dense plasmas and a pressure formula in the relativistic Pauli approximation. PMID- 9963200 TI - Effect of configuration widths on the spectra of local thermodynamic equilibrium plasmas. PMID- 9963201 TI - Influence of ion dynamics on the width and shift of isolated He I lines in plasmas. II. PMID- 9963202 TI - Time-resolved density measurements of x-ray-heated Teflon foils using absorption spectroscopy. PMID- 9963203 TI - Generally covariant relativistic anisotropic magnetohydrodynamics. PMID- 9963204 TI - Quasilinear evolution of cyclotron maser instability. PMID- 9963205 TI - Nonlinear response of electric fields at a neutral point. PMID- 9963206 TI - Stimulated microwave emission from E x B drifting electrons in slow-wave cavities: A quantum approach. PMID- 9963208 TI - Discreteness effects on the double sine-Gordon kink. PMID- 9963207 TI - Effects of a nonlinear damping force in synchrotrons with electron cooling. PMID- 9963210 TI - Numerical analyses of the collision of localized structures in the Davey Stewartson equations. PMID- 9963209 TI - Gap-soliton propagation in nonuniform gratings. PMID- 9963211 TI - Periodical waves, domain walls, and modulational instability in dispersive quadratic nonlinear media. PMID- 9963212 TI - Ground state of the Frenkel-Kontorova model with a transverse degree of freedom. PMID- 9963213 TI - Self-focusing of plane dark solitons in nonlinear defocusing media. PMID- 9963214 TI - Versatility and adaptive performance. PMID- 9963215 TI - Democratic reinforcement: A principle for brain function. PMID- 9963216 TI - Finite signal transmission times and synaptic memory in neural networks. PMID- 9963217 TI - Calculation of the dynamics of drug binding in a netropsin-DNA complex. PMID- 9963218 TI - Spontaneous nucleation of microtubules. PMID- 9963220 TI - Statistical mechanics of neocortical interactions: High-resolution path-integral calculation of short-term memory. PMID- 9963219 TI - Spatiotemporal processing in neural networks with random synaptic background activity. PMID- 9963221 TI - Long-range correlation properties of coding and noncoding DNA sequences: GenBank analysis. AB - An open question in computational molecular biology is whether long-range correlations are present in both coding and noncoding DNA or only in the latter. To answer this question, we consider all 33301 coding and all 29453 noncoding eukaryotic sequences--each of length larger than 512 base pairs (bp)--in the present release of the GenBank to dtermine whether there is any statistically significant distinction in their long-range correlation properties. Standard fast Fourier transform (FFT) analysis indicates that coding sequences have practically no correlations in the range from 10 bp to 100 bp (spectral exponent beta=0.00 +/- 0.04, where the uncertainty is two standard deviations). In contrast, for noncoding sequences, the average value of the spectral exponent beta is positive (0.16 +/- 0.05) which unambiguously shows the presence of long range correlations. We also separately analyze the 874 coding and the 1157 noncoding sequences that have more than 4096 bp and find a larger region of power law behavior. We calculate the probability that these two data sets (coding and noncoding) were drawn from the same distribution and we find that it is less than 10(-10). We obtain independent confirmation of these findings using the method of detrended fluctuation analysis (DFA), which is designed to treat sequences with statistical heterogeneity, such as DNA's known mosaic structure ("patchiness") arising from the nonstationarity of nucleotide concentration. The near-perfect agreement between the two independent analysis methods, FFT and DFA, increases the confidence in the reliability of our conclusion. PMID- 9963222 TI - Statistical errors in histogram reweighting. PMID- 9963223 TI - Asymptotic diffusion coefficient of particles in a random medium. PMID- 9963224 TI - Coherent structures in coupled map lattices. PMID- 9963225 TI - Instability of weakly nonlinear chaotic structures. PMID- 9963226 TI - Controlling the unstable steady state in a multimode laser. PMID- 9963227 TI - Supersymmetric time-continuous discrete random walks. PMID- 9963228 TI - Gibbs-ensemble molecular dynamics: Liquid-gas equilibrium in a Lennard-Jones system. PMID- 9963229 TI - Lyapunov exponents and the merger of point-vortex clusters. PMID- 9963230 TI - Equilibrium states of two-dimensional turbulence: An experimental study. PMID- 9963231 TI - Three-dimensional negative eddy viscosity effect on the onset of instability in some planar flows. PMID- 9963232 TI - Universal spatiotemporal scaling in the dynamics of one-dimensional pattern selection. PMID- 9963233 TI - Generalized Kelvin equation and the water content of a cloud. PMID- 9963235 TI - Relative intensities of Delta n=0 transitions within the n=2 and n=3 levels in nitrogenlike Ar XII from a theta -pinch plasma. PMID- 9963234 TI - Observation of O V visible transitions in a tokamak divertor plasma. PMID- 9963236 TI - Transient regime and superradiance in a short-pulse free-electron-laser oscillator. PMID- 9963237 TI - Relation between relativistic quantum mechanics and classical electromagnetic field theory. PMID- 9963238 TI - Algebraic solitary-wave polaritons in far-infrared transients. PMID- 9963239 TI - Scattering in a two-dimensional photonic crystal: An analytical model. PMID- 9963240 TI - Gibbs-ensemble path-integral Monte Carlo simulations of a mixed quantum-classical fluid. PMID- 9963241 TI - Comment on "Energy balance for a dissipative system" PMID- 9963242 TI - Reply to "Comment on 'Energy balance for a dissipative system' " PMID- 9963243 TI - How a solid can be turned into a gas without passing through a first-order phase transformation. PMID- 9963244 TI - Stochastic resonance in the strong-forcing limit. PMID- 9963245 TI - Theory of the size distribution in three-dimensional grain growth. PMID- 9963247 TI - Generating partition for the standard map. PMID- 9963246 TI - Geometric scaling of correlation decay in chaotic billiards. PMID- 9963248 TI - Statistical theory of sedimentation of disordered suspensions. PMID- 9963249 TI - Viscous fingering: A singularity in Laplacian growth models. PMID- 9963251 TI - Frequency selection of spiral waves in liquid crystals. PMID- 9963250 TI - Experimental indication of a devil's staircase structure in a smectic liquid crystal. PMID- 9963252 TI - Construction and investigation of a hard-sphere crystal-melt interface by a molecular dynamics simulation. PMID- 9963254 TI - Intermittent energy bursts and recurrent topological change of a twisting magnetic flux tube. PMID- 9963253 TI - Diffusion field around a dendrite growing under microgravity. PMID- 9963256 TI - Periodic forcing of a Brownian particle. PMID- 9963255 TI - Broken ergodicity and the geometry of rugged landscapes. PMID- 9963257 TI - Formulation of a moment method for multidimensional Fokker-Planck equations. PMID- 9963259 TI - Transmission fluctuations and spectral rigidity of lasing states in a random amplifying medium. PMID- 9963258 TI - Finite-size effects of correlation lengths in planar uniaxial ferromagnets. PMID- 9963261 TI - Resonant driving of chaotic orbits. PMID- 9963260 TI - Crucial formula for determination of the occurrence of the nonchaotic states in rf-biased nonlinear oscillators. PMID- 9963263 TI - Stochastic resonance in Ising systems. PMID- 9963262 TI - Theory of second- and higher-order stochastic processes. PMID- 9963264 TI - Nonlinear excitations and their energy spectra in one-dimensional bilinearly coupled spin systems. PMID- 9963265 TI - Chaotic scattering and diffusion in the Lorentz gas. PMID- 9963266 TI - Minimum energy dissipation river networks with fractal boundaries. PMID- 9963268 TI - Universal behavior of correlations between eigenvalues of random matrices. PMID- 9963267 TI - Bistability and oscillations in a surface reaction model. PMID- 9963269 TI - Synchronization and control in a unidirectionally coupled array of chaotic diode resonators. PMID- 9963271 TI - Long-time traces of the initial condition in relaxation phenomena near criticality. PMID- 9963270 TI - Statistical properties of the delay time matrix. PMID- 9963272 TI - Signatures of classical periodic orbits on a smooth quantum system. PMID- 9963273 TI - Numerical simulation of two-dimensional late-stage coarsening for nucleation and growth. PMID- 9963274 TI - Structure of random fractals and the probability distribution of random walks. PMID- 9963275 TI - Symmetry properties in surface growth models. PMID- 9963276 TI - Avoided crossings: Curvature distribution and behavior of eigenfunctions of pseudointegrable and chaotic billiards. PMID- 9963278 TI - Statics and dynamics of an interface in a temperature gradient. PMID- 9963277 TI - Universal correlations for deterministic plus random Hamiltonians. PMID- 9963280 TI - Early stage scaling in phase ordering kinetics. PMID- 9963279 TI - Long-time behavior of correlation functions in the finite ideal gas. PMID- 9963281 TI - Chaotic scattering in reactive collisions: A classical analysis. PMID- 9963282 TI - High-accuracy Trotter-formula method for path integrals. PMID- 9963283 TI - Energy-scaling approach to phase-ordering growth laws. PMID- 9963284 TI - Exact solution of a one-dimensional deterministic sandpile model. PMID- 9963285 TI - Genuine electromagnetic wave chaos. PMID- 9963287 TI - Ballistic annihilation in a one-dimensional fluid. PMID- 9963286 TI - Anomalous diffusion and the correspondence principle. PMID- 9963289 TI - Velocity autocorrelation function of interacting Brownian particles. PMID- 9963288 TI - Ballistic-annihilation kinetics for a multivelocity one-dimensional ideal gas. PMID- 9963290 TI - Dynamic temperature propagation in a pure fluid near its critical point observed under microgravity during the German Spacelab Mission D-2. PMID- 9963292 TI - Gabor transform and intermittency in turbulence. PMID- 9963291 TI - Molecular dynamics simulations of passive transport in two-dimensional Rayleigh Benard convection. PMID- 9963293 TI - Numerical renormalization-group calculations for similarity solutions and traveling waves. PMID- 9963294 TI - Scaling properties of a class of shell models. PMID- 9963295 TI - Fractal dimension of velocity signals in high-Reynolds-number hydrodynamic turbulence. PMID- 9963296 TI - Statistics of a passive scalar advected by a large-scale two-dimensional velocity field: Analytic solution. PMID- 9963297 TI - Entropy cascade and temporal intermittency in a shell model for convective turbulence. PMID- 9963298 TI - Convection in binary fluid mixtures. I. Extended traveling-wave and stationary states. PMID- 9963299 TI - Convection in binary fluid mixtures. II. Localized traveling waves. PMID- 9963300 TI - Turbulence and internal waves in side-heated convection. PMID- 9963301 TI - Equations of motion for superfluids. PMID- 9963302 TI - Quasiparticle pair creation in unstable superflow. PMID- 9963304 TI - Hydrodynamics of domain relaxation in a polymer monolayer. PMID- 9963303 TI - Strong-property-fluctuation theory for homogenizing chiral particulate composites. PMID- 9963305 TI - Sign inversion of the spontaneous polarization in induced liquid crystalline smectic-C* phases. PMID- 9963307 TI - Volumetric and transport properties in microemulsions and the point of view of percolation theory. PMID- 9963306 TI - Percolation disorder in viscous and nonviscous flow through porous media. PMID- 9963308 TI - Computer simulation study of the permeability of driven polymers through porous media. PMID- 9963309 TI - Critical behavior of the nematic-isotropic phase transition. PMID- 9963310 TI - Onsager's reciprocal relation and the hydraulic permeability of porous media. PMID- 9963311 TI - Metastable dynamics above the glass transition. PMID- 9963312 TI - Diffusion of clusters with randomly growing masses. PMID- 9963314 TI - Static and dynamic critical behavior of a binary polymer blend in the strong fluctuation limit: A light scattering study. PMID- 9963313 TI - Coil-globule transition of poly(methyl methacrylate) in a mixed solvent. PMID- 9963315 TI - Structure and dynamics of breaking foams. PMID- 9963317 TI - Polyelectrolyte configuration in a disordered medium. PMID- 9963316 TI - Hexatic order in thin smectic-F liquid-crystal films. PMID- 9963318 TI - Spinodal decomposition of a three-component water-in-oil microemulsion system. PMID- 9963319 TI - Domain structure and switching behavior of anisotropic gels. PMID- 9963320 TI - Density-functional theory and atomistic simulation of the hard-sphere melt-solid interface. PMID- 9963322 TI - Microscopic boundary layer model for a particle in entangled polymers: Steady state particle diffusivity. PMID- 9963321 TI - Effect of a stabilizing magnetic field on the electric-field-induced Freedericksz transition in 4-n-pentyl-4-cyanobiphenyl. PMID- 9963323 TI - Slippage of linear flows of entangled polymers on surfaces. PMID- 9963324 TI - Neutron-scattering studies of binary mixtures in silica gels. PMID- 9963325 TI - Conditional distribution function approach to the theory of the solid-nematic fluid interface. PMID- 9963326 TI - Electrohydrodynamic convection in a homeotropically aligned nematic sample. PMID- 9963327 TI - Simulation study of the isotropic-to-nematic transitions of semiflexible polymers. PMID- 9963329 TI - Monte Carlo study of living polymers with the bond-fluctuation method. PMID- 9963328 TI - High-pressure specific-heat spectroscopy at the glass transition in o-terphenyl. PMID- 9963330 TI - Migration and fragmentation of invasion percolation clusters in two-dimensional porous media. PMID- 9963332 TI - Critical behavior in the presence of a disordered environment. PMID- 9963331 TI - Interaction of dilute colloidal particles in a mixed solvent. PMID- 9963333 TI - Nonequilibrium molecular dynamics simulations of oscillatory sliding motion in a colloidal suspension system. PMID- 9963334 TI - Modulated structures of the smectic-C* phase in free-standing films with high spontaneous polarization. PMID- 9963335 TI - Structure of soft-sphere dipolar fluids. PMID- 9963336 TI - Phase coexistence of a Stockmayer fluid in an applied field. PMID- 9963337 TI - Effect of transport mechanisms on the irreversible adsorption of large molecules. PMID- 9963338 TI - Particle-cluster aggregation with dipolar interactions. PMID- 9963339 TI - Electric and thermal resistivities in dense high-Z plasmas. PMID- 9963340 TI - Diagnostics of plasmas with substantial concentrations of atomic oxygen. PMID- 9963341 TI - xuv spectra of optical-field-ionized plasmas. PMID- 9963342 TI - Transport coefficients in a weakly ionized nonequilibrium plasma. PMID- 9963343 TI - Ion kinetics and symmetric charge-transfer collisions in low-current, diffuse (Townsend) discharges in argon and nitrogen. PMID- 9963344 TI - Non-Taylor magnetohydrodynamic self-organization. PMID- 9963345 TI - Effects of relativistic electrons on the calculated collective Thomson scattered spectra. PMID- 9963347 TI - Experimental investigation and fast two-dimensional self-consistent kinetic modeling of a low-pressure inductively coupled rf discharge. PMID- 9963346 TI - Space-resolved electron density and temperature measurements of line-shaped laser plasmas. PMID- 9963348 TI - Linear and nonlinear modes in nonrelativistic electron-positron plasmas. PMID- 9963350 TI - Betatron coupling and related impact of radiation. PMID- 9963349 TI - Modeling of microwave discharges in the presence of plasma resonances. PMID- 9963352 TI - Observation of nonlinear localized modes in an electrical lattice. PMID- 9963351 TI - Nanometer-beam-size measurement during collisions at linear colliders. PMID- 9963353 TI - Time-dependent photon migration using path integrals. PMID- 9963355 TI - Bistability in simulated granular flow along corrugated walls. PMID- 9963354 TI - Deriving the transmission and reflection coefficients of an optically active medium without using boundary conditions. PMID- 9963356 TI - Optical conductance fluctuations: Diagrammatic analysis in the Landauer approach and nonuniversal effects. PMID- 9963357 TI - Friction-induced self-organization of a one-dimensional array of particles. PMID- 9963358 TI - Solvent effects on supercoiled DNA dynamics explored by Langevin dynamics simulations. PMID- 9963360 TI - Noise-induced synchronous neuronal oscillations. PMID- 9963359 TI - Simulation of hydrogen bonding and hydration in pure lipid bilayers. PMID- 9963361 TI - Dilution in a linear neural network. PMID- 9963362 TI - Algorithm to extract the spanning clusters and calculate conductivity in strip geometries. PMID- 9963363 TI - Control of systems with friction. PMID- 9963365 TI - Deterministic spontaneous appearance of traffic jams in slightly inhomogeneous traffic flow. PMID- 9963364 TI - Controlling chaos in unidimensional maps using constant feedback. PMID- 9963366 TI - Departure from Boltzmann-Gibbs statistics makes the hydrogen-atom specific heat a computable quantity. PMID- 9963367 TI - Self-similarity in rain forests: Evidence for a critical state. PMID- 9963368 TI - Predicting and characterizing data sequences from structure-variable systems. PMID- 9963369 TI - Reaction kinetics of annihilating particles with anomalous diffusion. PMID- 9963370 TI - Estimation of the order-parameter exponent of critical cellular automata using the enhanced coherent anomaly method. PMID- 9963371 TI - Quantum dissipation is a dynamical collective effect. PMID- 9963372 TI - Kinetic equations for a dissipative quantum system driven by dichotomous noise: An exact result. PMID- 9963374 TI - Asymptotic dissipation rate in turbulence. PMID- 9963373 TI - Single-particle distributions for small hard particle systems in the microcanonical and in the molecular-dynamics ensembles. PMID- 9963375 TI - Elasticity-driven texture selection mechanism in mesophase carbon fibers. PMID- 9963376 TI - Shear-induced orientational effects in discotic-liquid-crystal micelles. PMID- 9963378 TI - Excitation mechanism of hydrogen Balmer lines in a fast plasma-mixing device. PMID- 9963377 TI - Influence of gravity on the jamming-limit coverage for the random deposition of large spheres on one- and two-dimensional collectors. PMID- 9963379 TI - Plasma-beam interaction in a wiggler. PMID- 9963380 TI - Periodic solitons in optics. PMID- 9963381 TI - Enhanced transmission due to disorder. PMID- 9963382 TI - Parametric x radiation from thick crystals. PMID- 9963383 TI - Storage capacity and generalization error for the reversed-wedge Ising perceptron. PMID- 9963384 TI - Comment on "Signature of classical chaos on quantum tunneling" PMID- 9963385 TI - Comment on "Two-loop renormalization-group analysis of the Burgers-Kardar-Parisi Zhang equation" PMID- 9963386 TI - Reply to "Comment on 'Two-loop renormalization-group analysis of the Burgers Kardar-Parisi-Zhang equation' " PMID- 9963387 TI - Fractal potentials from energy levels. PMID- 9963388 TI - Reply to "Fractal potentials from energy levels" PMID- 9963389 TI - Erratum: Eigenspectrum and localization for diffusion with traps PMID- 9963391 TI - Normalization sum rule and spontaneous breaking of U(N) invariance in random matrix ensembles. PMID- 9963390 TI - Percolation and the pore geometry of crustal rocks. PMID- 9963392 TI - Kinetics of phase ordering with topological textures. PMID- 9963394 TI - Some inertial range correlators in fully developed turbulence. PMID- 9963393 TI - Traveling-wave fragments in anisotropic excitable media. PMID- 9963396 TI - Anchoring strength of a lyotropic nematic liquid crystal. PMID- 9963395 TI - Chemically driven convection can stabilize Turing patterns. PMID- 9963397 TI - Heat front propagation in femtosecond-laser-heated solids. PMID- 9963398 TI - Observation of coherent Smith-Purcell radiation from short-bunched electrons. PMID- 9963400 TI - Possible universality in the size distribution of fish schools. PMID- 9963399 TI - Halo formation induced by density nonuniformities in intense ion beams. PMID- 9963401 TI - Equation of state of a hydrogen plasma by density functional molecular dynamics. PMID- 9963402 TI - Potts model on the Bethe lattice with mixed interactions. PMID- 9963403 TI - Localization in disordered structures: Breakdown of the self-averaging hypothesis. PMID- 9963404 TI - Coherence-preserving chaos in a mixed quantum classical description. PMID- 9963405 TI - Open surfaces and gauge-invariant Ising models. PMID- 9963407 TI - Catalysis on microstructured surfaces: Pattern formation during CO oxidation in complex Pt domains. PMID- 9963406 TI - Self-organized critical scaling at surfaces. PMID- 9963408 TI - Experimental control of chaos in a laser. PMID- 9963409 TI - Dynamics of spiral waves in excitable media subjected to external periodic forcing. PMID- 9963410 TI - Systematic perturbation solution for Brownian motion in a biased periodic potential field. PMID- 9963412 TI - Global stability of stationary patterns in bistable reaction-diffusion systems. PMID- 9963411 TI - Coupled map lattices as models of deterministic and stochastic differential delay equations. PMID- 9963413 TI - Simulating a Brownian type of motion: The rescaling-velocity approach versus the Langevin approach. PMID- 9963415 TI - Influence of defects in a coupled map lattice modeling earthquakes. PMID- 9963414 TI - Statistical measures of chaos in quantum systems. PMID- 9963416 TI - Colored-noise problem: A Markovian interpolation procedure. PMID- 9963417 TI - Semiclassical model for quantum dissipation. PMID- 9963418 TI - Quantum transition-state theory below the crossover temperature. PMID- 9963419 TI - Off-diagonal long-range order, pair distribution function, and structure factor of the ideal Fermi gas in D dimensions and Price's inequality. PMID- 9963420 TI - Kolmogorov-Smirnov test distinguishes attractors with similar dimensions. PMID- 9963422 TI - Blending chaotic attractors using the synchronization of chaos. PMID- 9963421 TI - Distribution of the first return time in fractional Brownian motion and its application to the study of on-off intermittency. PMID- 9963424 TI - Determination of limit cycles for two-dimensional dynamical systems. PMID- 9963423 TI - Traffic jams, granular flow, and soliton selection. PMID- 9963425 TI - Thermal Schrodinger equation. PMID- 9963426 TI - Lattice thermal conductivity via homogeneous nonequilibrium molecular dynamics. PMID- 9963427 TI - Oscillatory instability in thermal cracking: A first-order phase-transition phenomenon. PMID- 9963428 TI - Coarsening in the q-state Potts model and the Ising model with globally conserved magnetization. PMID- 9963429 TI - Spatial properties of integrable and nonintegrable discrete nonlinear Schrodinger equations. PMID- 9963431 TI - Singular continuous spectra in dissipative dynamics. PMID- 9963430 TI - Growth of long-range correlations after a quench in phase-ordering systems. PMID- 9963432 TI - Searching periodic orbits with a modulation based on Shannon entropy. PMID- 9963433 TI - Brownian motion in fluctuating media. PMID- 9963434 TI - Shock waves and time scales to reach equipartition in the Fermi-Pasta-Ulam model. PMID- 9963436 TI - Cell-dynamics modeling of oscillator systems. PMID- 9963435 TI - Stochastic resonance in a mean-field model of cooperative behavior. PMID- 9963437 TI - Nonlinear dynamic elements with noisy sinusoidal forcing: Enhancing response via nonlinear coupling. PMID- 9963438 TI - Measurement trajectories of chaotic quantum systems. PMID- 9963439 TI - Unified inversion technique for fermion and boson integral equations. PMID- 9963440 TI - Method to study relaxation of metastable phases: Macroscopic mean-field dynamics. PMID- 9963441 TI - Surface roughening with quenched disorder in high dimensions: Exact results for the Cayley tree. PMID- 9963443 TI - Mean first-passage times for systems driven by equilibrium persistent-periodic dichotomous noise. PMID- 9963442 TI - Semiclassical quantization using Bogomolny's quantum surface of section. PMID- 9963444 TI - Exact calculations of the relaxation for a model of electron transfer with strong electronic coupling. PMID- 9963445 TI - Stochastic dynamics of quantum jumps. PMID- 9963446 TI - Lattice plasma in infinitely many dimensions. PMID- 9963448 TI - Dynamic interaction between discontinuity and noninvertibility: An analytical study. PMID- 9963447 TI - Correlations in binary sequences and a generalized Zipf analysis. PMID- 9963450 TI - Nonlinear resonance and chaos in the relativistic phase space for driven nonlinear systems. PMID- 9963449 TI - Extended and localized states of generalized kicked Harper models. PMID- 9963451 TI - Iterated function system and diffusion in the presence of disorder and traps. PMID- 9963453 TI - Global flow waves in chemically induced convection. PMID- 9963452 TI - Phase of the Riemann zeta function and the inverted harmonic oscillator. PMID- 9963454 TI - Negative dimensions of the turbulent dissipation field. PMID- 9963455 TI - Correlations and renormalization in lattice gases. PMID- 9963456 TI - Inhomogeneity of viscous aqueous solutions. PMID- 9963457 TI - Langmuir turbulence and three-wave nonlinear dynamics. PMID- 9963458 TI - Analytic solution of the mean spherical approximation for a dipolar hard-sphere fluid with intracore anisotropic sticky interactions. PMID- 9963459 TI - Ellipsometric measurement of universal critical adsorption integrals. PMID- 9963460 TI - Description of the geometrical and topological structure in amphiphilic systems. PMID- 9963461 TI - Critical-point and coexistence-curve properties of the Lennard-Jones fluid: A finite-size scaling study. PMID- 9963462 TI - Density expansion for the mobility in a quantum Lorentz model. PMID- 9963463 TI - Temperature and entropy production operator in Fourier heat conduction. PMID- 9963465 TI - Model of intermittency in magnetohydrodynamic turbulence. PMID- 9963464 TI - Instability nature of the swirl appearance in liquid cones. PMID- 9963466 TI - Influence of the Dufour effect on convection in binary gas mixtures. PMID- 9963467 TI - Dynamical simulation of fluidized beds: Hydrodynamically interacting granular particles. PMID- 9963468 TI - Off-specular x-ray scattering in Langmuir-Blodgett multilayers of a liquid crystalline polymer. PMID- 9963469 TI - Director deformation of a twisted chiral nematic liquid crystal cell with weak anchoring boundaries. PMID- 9963470 TI - Nematic order director fluctuations and nuclear magnetic relaxation of a confined liquid crystal. PMID- 9963472 TI - Alignment tensor versus director: Description of defects in nematic liquid crystals. PMID- 9963471 TI - Tetrahedral symmetry in nematic liquid crystals. PMID- 9963473 TI - Video microscope and elastic light scattering studies of fast-mode kinetics in surface-mediated spinodal decomposition. PMID- 9963475 TI - Dynamics in viscous orthoterphenyl: Results from coherent neutron scattering. PMID- 9963474 TI - Hydrodynamic interaction of particles with grafted polymer brushes and applications to rheology of colloidal dispersions. PMID- 9963476 TI - Static and dynamic light scattering in nonionic critical micellar solutions of water-pentaethylene glycol n-dodecylether. PMID- 9963478 TI - Cluster formation, standing waves, and stripe patterns in oscillatory active media with local and global coupling. PMID- 9963477 TI - Adsorption in a spherical cavity. PMID- 9963480 TI - Neutron scattering study of the picosecond dynamics of polybutadiene and polyisoprene. PMID- 9963479 TI - Curvature controlled wetting in two dimensions. PMID- 9963481 TI - Scaling of fractal aggregates. PMID- 9963482 TI - Fluid diffusion through a porous solid: Nonequilibrium molecular-dynamics simulation. PMID- 9963483 TI - Concentration dependence of solution shear viscosity and solute mass diffusivity in crystal growth from solutions. PMID- 9963484 TI - Viscosity of a one-component polarizable fluid. PMID- 9963485 TI - Geometrical percolation threshold of overlapping ellipsoids. PMID- 9963486 TI - Spinodal decomposition of a symmetric binary fluid mixture in quasi two dimensions: Local orientational ordering of fluid tubes. PMID- 9963487 TI - Randomly charged polymers: An exact enumeration study. PMID- 9963488 TI - Experimental probes of bond orientational order models of blue phase III of chiral liquid crystals. PMID- 9963489 TI - Metastable dynamics of the hard-sphere system. PMID- 9963490 TI - Making a (colloidal) liquid: A van der Waals approach. PMID- 9963491 TI - Hierarchically correlated patterns in Potts neural networks. PMID- 9963492 TI - Multifractal analysis of solvent accessibilities in proteins. PMID- 9963494 TI - Chromosome mapping: Radiation hybrid data and stochastic spin models. PMID- 9963493 TI - Replica symmetry breaking in a diluted network with binary couplings. PMID- 9963495 TI - Helical coordinate system and electrostatic fields of double-helix charge distributions. PMID- 9963496 TI - Pinned polymer model of posture control. PMID- 9963497 TI - Excitation of Ar lines in the cathode region of a dc discharge. PMID- 9963498 TI - Heavy-ion interaction in a nonisothermal plasma with two-ion correlation effects. PMID- 9963499 TI - Vortex filament dynamics in plasmas and superconductors. PMID- 9963500 TI - Effect of plasma single-particle excitations on the rate of nuclear reactions in the sun. PMID- 9963501 TI - Front-curvature effects in the dynamics of confined radiatively bistable plasmas: Perfect patterns and Ostwald ripening. PMID- 9963502 TI - Electron distribution function in a low-pressure inductively coupled plasma. PMID- 9963503 TI - Tunability of free-electron lasers. PMID- 9963504 TI - Influence of multiple electron scattering on the gain in a gas-loaded free electron laser. PMID- 9963505 TI - Theory of relativistic cyclotron masers. PMID- 9963506 TI - Two-dimensional charge densities in intense rectangular ion beams with space charge neutralization. PMID- 9963507 TI - Transverse stability of bunch trains. PMID- 9963509 TI - Refractive indices for extraordinary waves in uniaxial crystals. PMID- 9963508 TI - Muon transverse ionization cooling: Stochastic approach. PMID- 9963511 TI - Soliton interaction near the zero-dispersion wavelength. PMID- 9963510 TI - Nonlinear electromagnetics in chiral media: Self-action of waves. PMID- 9963512 TI - Modulational instabilities in dispersion-flattened fibers. PMID- 9963513 TI - Nonlinear anomalous ferromagnetic Faraday effect. PMID- 9963514 TI - Structural properties of kinks and domain walls in nonlinear oscillatory lattices. PMID- 9963516 TI - Propagation in random media: Calculation of the effective dispersive permittivity by use of the replica method. PMID- 9963515 TI - Solitons in the periodic Korteweg-de Vries equation, the FTHETA-function representation, and the analysis of nonlinear, stochastic wave trains. PMID- 9963517 TI - Stochastic model for tunneling processes: The question of superluminal behavior. PMID- 9963518 TI - Photonic band gaps for arrays of perfectly conducting cylinders. PMID- 9963519 TI - Statistical properties of the eigenfrequency distribution of three-dimensional microwave cavities. PMID- 9963521 TI - Solid-fluid boundaries in particle suspension simulations via the lattice Boltzmann method. PMID- 9963520 TI - Stationary soliton bound states existing in resonance with linear waves. PMID- 9963523 TI - Simultaneous multigrid techniques for nonlinear eigenvalue problems: Solutions of the nonlinear Schrodinger-Poisson eigenvalue problem in two and three dimensions. PMID- 9963522 TI - Fast Monte Carlo algorithms for knotted polymers. PMID- 9963524 TI - Construction of invariant tori in chaotic regions. PMID- 9963525 TI - Analytic approach to the problem of convergence of truncated Levy flights towards the Gaussian stochastic process. PMID- 9963526 TI - Mechanism of noise-induced resonance. PMID- 9963527 TI - Transition density of diffusion on the Sierpinski gasket and extension of Flory's formula. PMID- 9963528 TI - Universal scaling in coupled maps. PMID- 9963529 TI - Geometric properties of isovorticity surfaces in magnetohydrodynamic turbulence. PMID- 9963530 TI - Nonequilibrium structures in reacting fluids subject to external forces. PMID- 9963531 TI - Critical behavior of heat capacity at the smectic-C alpha *-smectic-A transition of the antiferroelectric liquid crystal methylheptyloxycarbonylphenyl octyloxybiphenyl carboxylate (MHPOBC). PMID- 9963532 TI - Influence of spatial inhomogeneities on the Freedericksz threshold. PMID- 9963533 TI - Diverging length scales at first-order wetting transitions. PMID- 9963534 TI - Analytic treatment of cooperativity effects in supercooled liquids within the framework of the random-walk model. PMID- 9963535 TI - Partially polarized beams in nonlinear Thomson scattering. PMID- 9963536 TI - Line integral formula for scattering of waves from a thin plate. PMID- 9963537 TI - Modulational instability of an axisymmetric state in a two-dimensional Kerr medium. PMID- 9963539 TI - Comment on "Fluctuating interfaces in microemulsion and sponge phases" PMID- 9963538 TI - Nonlinear transient dynamics of the driven Klein-Gordon solitons. PMID- 9963540 TI - Reply to "Comment on 'Fluctuating interfaces in microemulsion and sponge phases' " PMID- 9963541 TI - Dynamical properties of a growing surface on a random substrate. PMID- 9963542 TI - Universality in models for disorder-induced phase transitions. PMID- 9963544 TI - Slow domain growth in a system with competing interactions. PMID- 9963543 TI - Existence of long-range order in the steady state of a two-dimensional, two temperature XY model. PMID- 9963545 TI - In-plane anchoring energy in ferroelectric liquid crystals: Evidence for its existence and measurement. PMID- 9963546 TI - Evidence for a discotic smectic-nematic phase induced in Langmuir-Blodgett films. PMID- 9963547 TI - Structure of molecular liquids. PMID- 9963548 TI - Bulk and surface correlations in a microemulsion. PMID- 9963549 TI - Dynamics of concentration-dependent ionic currents. PMID- 9963551 TI - Nonunique stationary states in driven collisional systems with application to plasmas. PMID- 9963550 TI - Modified Mackey-Glass model of respiration control. PMID- 9963553 TI - Sporadic chaos in space-time dynamical processes. PMID- 9963552 TI - Expected number of sites visited by a constrained n-step random walk. PMID- 9963554 TI - Microparticle driven by parametric and random forces: Theory and experiment. PMID- 9963555 TI - Semiclassical features in the quantum description of a Dirac particle in a cavity. PMID- 9963556 TI - Energy density profiles in critical films. PMID- 9963557 TI - Monte Carlo simulation of phase transitions in a two-dimensional random-bond Potts model. PMID- 9963558 TI - Multifractal analysis: Pitfalls of standard procedures and alternatives. PMID- 9963559 TI - Scaling of hysteresis in the Ising model and cell-dynamical systems in a linearly varying external field. PMID- 9963560 TI - Evolution of probability densities in stochastic coupled map lattices. PMID- 9963561 TI - Emergence of quasiperiodicity in symmetrically coupled, identical period-doubling systems. PMID- 9963563 TI - Generalization of the Planck radiation law and application to the cosmic microwave background radiation. PMID- 9963562 TI - Hysteresis in a quantum spin model. PMID- 9963564 TI - Thermodynamics in the presence of electromagnetic fields. PMID- 9963566 TI - Dielectric-breakdown-type crack-growth models and the fractal distribution of earthquake faults. PMID- 9963565 TI - Effects of mobile vacancies on the dynamics of ordering and phase separation in nonconserved multicomponent systems. PMID- 9963567 TI - Dynamics of two coupled van der Pol oscillators. PMID- 9963568 TI - Plane-wave quantization for polygonal billiards. PMID- 9963569 TI - Topologically inequivalent embeddings. PMID- 9963570 TI - Static and dynamic two-dimensional patterns in self-extinguishing discharge avalanches. PMID- 9963571 TI - Periodic lattices of chaotic defects. PMID- 9963572 TI - Distribution of the number of distinct sites visited by random walks in disordered lattices. PMID- 9963573 TI - Control of low-dimensional spatiotemporal chaos in Fourier space. PMID- 9963575 TI - Properties of border states of transient chaos. PMID- 9963574 TI - Brownian parametric quantum oscillator with dissipation. PMID- 9963577 TI - Brownian type of motion of a randomly kicked particle far from and close to the diffusion limit. PMID- 9963576 TI - Ordering kinetics of two-dimensional O(2) models: Scaling and temperature dependence. PMID- 9963578 TI - Injection-induced bifurcations of transverse spatiotemporal patterns in semiconductor laser arrays. PMID- 9963579 TI - Thermally activated escape with potential fluctuations driven by an Ornstein Uhlenbeck process. PMID- 9963580 TI - Growth of long-range correlations in a transition between heat conduction and convection. PMID- 9963581 TI - Convective instabilities induced by an exothermic autocatalytic chemical reaction. PMID- 9963582 TI - Calculation of the dynamics of gravity-induced density profiles near a liquid vapor critical point. PMID- 9963583 TI - Pressure tensor for inhomogeneous fluids. PMID- 9963585 TI - Source-enhanced condensation in monocomponent disperse systems. PMID- 9963584 TI - Unsteady models for the nonlinear evolution of the mixing layer. PMID- 9963587 TI - Kinetic structure of a two-dimensional liquid. PMID- 9963586 TI - Effects of conductivity in electric-field-induced aggregation in electrorheological fluids. PMID- 9963588 TI - Stress tensor and viscosity of water: Molecular dynamics and generalized hydrodynamics results. PMID- 9963589 TI - Steady-state shear flows via nonequilibrium molecular dynamics and smooth particle applied mechanics. PMID- 9963590 TI - Self-organization of solitons for the dissipative Korteweg-de Vries equation. PMID- 9963591 TI - Nucleation structures in reaction-diffusion-convection systems. PMID- 9963592 TI - Hydrodynamics from dissipative particle dynamics. PMID- 9963593 TI - Renormalization-group analysis of the smectic-A1-smectic-Ad phase transition in liquid crystals. PMID- 9963594 TI - Multicritical point involving hexatic smectic phases. PMID- 9963595 TI - Modeling molecular order and dynamics of a liquid crystal by deuteron NMR. PMID- 9963597 TI - Front propagation into unstable and metastable states in smectic-C* liquid crystals: Linear and nonlinear marginal-stability analysis. PMID- 9963596 TI - Mean-field coefficients and the electroclinic effect of a ferroelectric liquid crystal. PMID- 9963598 TI - Topology and nematic ordering. I. A gauge theory. PMID- 9963599 TI - Topology and nematic ordering. II. Observable critical behavior. PMID- 9963600 TI - Effect of shear flow on the turbidity of a critical colloidal dispersion. PMID- 9963601 TI - Ostwald ripening in a two-dimensional system: Correlation effects. PMID- 9963602 TI - Metastability in fluctuation-driven first-order transitions: Nucleation of lamellar phases. PMID- 9963603 TI - Optical investigations in the various phases of an antiferroelectric liquid crystal. PMID- 9963604 TI - Extinction cross section of an arbitrary body in a viscous incompressible fluid. PMID- 9963605 TI - Multiparticle reactions with spatial anisotropy. PMID- 9963606 TI - Critical behavior of a cationic-surfactant-water-salt system near and far from the Krafft temperature. PMID- 9963607 TI - Crossover from flocculation to gelation in two-dimensional aggregation induced by an alternating electrical field. PMID- 9963608 TI - Computer simulation of the rheology of grafted chains under shear. PMID- 9963609 TI - Linear viscoelasticity in lipid bilayers of vesicles. PMID- 9963611 TI - Regulation of ramified electrochemical growth by a diffusive wave. PMID- 9963610 TI - From monolayers to bilayers: Effective rigidity and compressibility in asymmetric ternary amphiphilic systems. PMID- 9963612 TI - Phase diagram and critical behavior of the ferromagnetic Heisenberg fluid from density-functional theory. PMID- 9963614 TI - Electrorheological resonance observed in a colloidal suspension. PMID- 9963613 TI - Failure of the Harris criterion for directed polymers on hierarchical lattices. PMID- 9963616 TI - Statistical physics theory of query learning by an ensemble of higher-order neural networks. PMID- 9963615 TI - Quantitative analysis of the nonlinear relationship between neutron or x-ray reflectance and the scattering-length-density profile. PMID- 9963617 TI - Gradient descent learning in perceptrons: A review of its possibilities. PMID- 9963618 TI - Large relativistic density pulses in electron-positron-ion plasmas. PMID- 9963619 TI - High-resolution measurement, line identification, and spectral modeling of the K beta spectrum of heliumlike Ar16+ PMID- 9963620 TI - Radiation scattering in intense-field harmonic-generation experiments. PMID- 9963621 TI - Spectroscopic study of laser-produced plasmas in hydrogen. PMID- 9963622 TI - Length scale, quasiperiodicity, resonances, separatrix crossings, and chaos in the weakly relativistic Zakharov equations. PMID- 9963624 TI - Computer simulation of dislocation dechanneling in bent crystals at tera-electron volt energies. PMID- 9963623 TI - High-efficiency beam-wave interaction in quasiperiodic structures. PMID- 9963626 TI - Periodic trajectories in right-triangle billiards. PMID- 9963625 TI - Third cumulant of the total transmission of diffuse waves. PMID- 9963627 TI - Granular temperature: Experimental analysis. PMID- 9963628 TI - Stochastic phase space dynamics with constraints for molecular systems. PMID- 9963629 TI - Transient and crisis-induced intermittencies in high-power ferromagnetic resonance. PMID- 9963630 TI - Langevin description of the response of a stochastic mean-field model driven by a time-periodic field. PMID- 9963631 TI - Transition to nonchaotic behavior in a Brownian-type motion. PMID- 9963632 TI - Preferred equilibrium structures of a smectic-A phase grown from an isotropic phase: Origin of focal conic domains. PMID- 9963633 TI - Particle-particle aggregation with 1/r2 forces in reduced gravity environments. PMID- 9963634 TI - Determination of minimum-dissipation states with self-consistent resistivity in magnetized plasmas. PMID- 9963636 TI - Forward scattering of light in inhomogeneous binary dielectric media. PMID- 9963635 TI - Experimental control of chaos in a periodically driven glow discharge. PMID- 9963638 TI - Reply to "Comment on 'Absence of chaos in a self-organized critical coupled map lattice' " PMID- 9963637 TI - Comment on "Absence of chaos in a self-organized critical coupled map lattice" PMID- 9963639 TI - Comment on "Small-scale intermittency in randomly stirred fluids" PMID- 9963640 TI - Erratum: Statistical cycling in coupled map lattices PMID- 9963641 TI - Erratum: Orientation of alkyl chains and hindered rotation of carbonyl groups in the smectic-C* phase of antiferroelectric liquid crystals studied by polarized Fourier transform infrared spectroscopy PMID- 9963642 TI - Desynchronization by periodic orbits. PMID- 9963643 TI - Surface deconstruction and roughening in the multiziggurat model of wetting. PMID- 9963644 TI - Growth equation with a conservation law. PMID- 9963645 TI - On-off intermittency in a coupled-map lattice system. PMID- 9963646 TI - Unusual universality of branching interfaces in random media. PMID- 9963647 TI - Internal surface, orientational order, and distribution of a polymer network in a liquid crystal matrix. PMID- 9963649 TI - Flow topology associated with disjoint eddies in an asymmetric film-splitting problem. PMID- 9963648 TI - Transverse interlayer order in lyotropic smectic liquid crystals. PMID- 9963650 TI - Step-by-step thinning of free-standing films above the smectic-A-nematic phase transition. PMID- 9963651 TI - Ginzburg criterion for the mean-field to three-dimensional Ising crossover in polymer blends. PMID- 9963652 TI - Renormalization group analysis of the anisotropic Kardar-Parisi-Zhang equation with spatially correlated noise. PMID- 9963653 TI - Anomalous roughness exponent of growing interfaces in a disordered medium. PMID- 9963654 TI - Folding RNA with the minimal loss of entropy. PMID- 9963655 TI - Self-focusing of ion channels in cell adhesion. PMID- 9963656 TI - Effects of laser spatial incoherence with finite correlation length on the space time behavior of backscattering instabilities. PMID- 9963657 TI - Spectral distribution of drums with fractal perimeters: The Weyl-Berry-Lapidus conjecture. PMID- 9963658 TI - Field behavior of an Ising model with competing interactions on the Bethe lattice. PMID- 9963659 TI - Fluctuations close to equilibrium. PMID- 9963660 TI - Calculation by scaling of highly excited states of billiards. PMID- 9963661 TI - Two exact lattice propagators. PMID- 9963662 TI - Thermodynamic approach to deterministic diffusion of mixed enhanced-dispersive type. PMID- 9963663 TI - Parametric spectral correlations of disordered systems in the Fourier domain. PMID- 9963665 TI - Computational study of effects of uniaxial compression during processes of spinodal decomposition. PMID- 9963664 TI - Crystallization patterns of monomers with a nearest-neighbor interaction on a multilayered semi-infinite square lattice. PMID- 9963666 TI - Fluctuations and decoherence in classical chaos: A model study of a Kubo oscillator generated by a chaotic system. PMID- 9963668 TI - Lagrangians of physics and the game of Fisher-information transfer. PMID- 9963667 TI - Crisis-induced intermittency in a third-order electrical circuit. PMID- 9963669 TI - Multiple responses at the boundaries of the vulnerable window in the Belousov Zhabotinsky reaction. PMID- 9963671 TI - Translational invariance in the kicked harmonic oscillator. PMID- 9963670 TI - Transition to chaos in a laser system with delayed feedback. PMID- 9963672 TI - Monomer-dimer surface-reaction model: Influence of the dimer adsorption mechanism. PMID- 9963673 TI - Estimation of mutual information using kernel density estimators. PMID- 9963674 TI - Characterization of low-energy mode vibrations in chaos using entropy balance versus the amplitude-based Karhunen-Loeve expansion. PMID- 9963675 TI - Natural symmetries and regularization by means of weak parametric modulations in the forced pendulum. PMID- 9963677 TI - Saddles, singularities, and extrema in random phase fields. PMID- 9963676 TI - Thermostatted molecular dynamics: How to avoid the Toda demon hidden in Nose Hoover dynamics. PMID- 9963678 TI - Clustering and relaxation in Hamiltonian long-range dynamics. PMID- 9963679 TI - Analysis of sensor signals shows turning on a lathe exhibits low-dimensional chaos. PMID- 9963680 TI - Alternative method to find orbits in chaotic systems. PMID- 9963682 TI - Lyapunov exponents of systems with elastic hard collisions. PMID- 9963681 TI - Dynamics of the dissipative two-level system driven by external telegraph noise. PMID- 9963684 TI - Solid-on-solid model with next-nearest-neighbor interaction for epitaxial growth. PMID- 9963683 TI - Reaction-diffusion system with Brusselator kinetics: Control of a quasiperiodic route to chaos. PMID- 9963685 TI - Universal time dependence of the mean-square displacement in extremely rugged energy landscapes with equal minima. PMID- 9963687 TI - Survival of deterministic dynamics in the presence of noise and the exponential decay of power spectra at high frequency. PMID- 9963686 TI - Semiclassical study of avoided crossings. PMID- 9963689 TI - Spectral statistics in the quantized cardioid billiard. PMID- 9963688 TI - Quenching a rotating vortex in an excitable medium. PMID- 9963691 TI - Coupled maps on trees. PMID- 9963690 TI - Diffusive hysteresis at high and low driving frequencies. PMID- 9963692 TI - Reduction of overdamped stochastic processes in the coherent state representation. PMID- 9963694 TI - Markovian and rotating-wave approximations versus exact solution of damped quantum oscillator. PMID- 9963693 TI - Decoherence, delocalization, and irreversibility in quantum chaotic systems. PMID- 9963696 TI - Spatial organization in the reaction A+B-->(inert) for particles with drift. PMID- 9963695 TI - Phase ordering in the Ising model with conserved spin. PMID- 9963698 TI - Intermittency effects inherent in turbulence. PMID- 9963697 TI - Kinetics of A+B-->0 with driven diffusive motion. PMID- 9963699 TI - Boundary-layer turbulence as a kangaroo process. PMID- 9963701 TI - Diffusive transport in a one-dimensional disordered potential involving correlations. PMID- 9963700 TI - Structural approach to the modeling of a turbulent mixing layer. PMID- 9963702 TI - Microcirculations in turbulent flows. PMID- 9963703 TI - Shear viscosity from a dynamic density-functional theory. PMID- 9963704 TI - Scaling theory of particle annihilation in systems with a long-range interaction. PMID- 9963706 TI - Finite-amplitude regimes of the short-wave Marangoni-Benard convective instability. PMID- 9963705 TI - Rheological properties of confined thin films. PMID- 9963707 TI - Dynamics of the passive scalar in compressible turbulent flow: Large-scale patterns and small-scale fluctuations. PMID- 9963708 TI - Algorithm to compute void statistics for random arrays of disks. PMID- 9963709 TI - Differential theory of fluids below the critical temperature: Study of the Lennard-Jones fluid and of a model of C60. PMID- 9963711 TI - Triplet structure of simple liquids. PMID- 9963710 TI - Long-time tails in lattice gases violating detailed balance. PMID- 9963713 TI - Origins of the two-step relaxation and the boson peak in an alkali silicate glass studied by molecular-dynamics simulation. PMID- 9963712 TI - Long-range correlations in nonequilibrium Lorentz gases. PMID- 9963714 TI - Dimerlike smectic-A and -C phases in highly fluorinated thermotropic liquid crystals. PMID- 9963715 TI - Symmetry of the Freedericksz transition in nonchiral nematic liquid crystals. PMID- 9963716 TI - Influence of the saddle-splay energy on the structure of cholesteric liquid crystals confined to a capillary. PMID- 9963718 TI - Variational bounds for first-passage-time problems in stratified porous media. PMID- 9963717 TI - Rotational diffusion in concentrated colloidal dispersions of hard spheres. PMID- 9963720 TI - Phase separation of binary fluids in porous media: Asymmetries in pore geometry and fluid composition. PMID- 9963719 TI - Finite-element analysis of electrostatic interactions in electrorheological fluids. PMID- 9963721 TI - Structure and dynamics of C60 molecules in liquid CS2 from neutron scattering. PMID- 9963722 TI - Mobility of a reptating polymer with fast diffusion of stored length. PMID- 9963723 TI - Adsorption and desorption of a wetting fluid in Vycor studied by acoustic and optical techniques. PMID- 9963724 TI - Three-dimensional dendrite-tip morphology. PMID- 9963725 TI - Dynamic correlations in a dense dipolar liquid. PMID- 9963726 TI - Effect of substrate corrugation on the spreading of polymer droplets. PMID- 9963727 TI - Diffusion of a self-avoiding polymer. PMID- 9963728 TI - Late-stage kinetics of systems with competing interactions quenched into the hexagonal phase. PMID- 9963729 TI - Effects of long-range repulsive interactions on Ostwald ripening. PMID- 9963730 TI - Finite-size effects in diffusion-limited aggregation. PMID- 9963732 TI - Information theory and local learning rules in a self-organizing network of Ising spins. PMID- 9963731 TI - Surface effects on spinodal decomposition in the framework of a linearized theory. PMID- 9963733 TI - Collective aspects of protein folding illustrated by a toy model. PMID- 9963734 TI - On-line versus off-line learning in the linear perceptron: A comparative study. PMID- 9963735 TI - Pseudoinverse techniques, information theory, and the training of feedforward networks. PMID- 9963737 TI - Synchronization in a network of neuronal oscillators with finite storage capacity. PMID- 9963736 TI - Predicting slow structural transitions in macromolecular systems: Conformational flooding. PMID- 9963738 TI - Statistical mechanics of supercoiled DNA. PMID- 9963740 TI - Nonlinear excitations in two-dimensional molecular structures with impurities. PMID- 9963741 TI - Observation of KL-->LL x-ray satellites of aluminum in femtosecond laser-produced plasmas. PMID- 9963739 TI - Systematic analysis of coding and noncoding DNA sequences using methods of statistical linguistics. AB - We compare the statistical properties of coding and noncoding regions in eukaryotic and viral DNA sequences by adapting two tests developed for the analysis of natural languages and symbolic sequences. The data set comprises all 30 sequences of length above 50 000 base pairs in GenBank Release No. 81.0, as well as the recently published sequences of C. elegans chromosome III (2.2 Mbp) and yeast chromosome XI (661 Kbp). We find that for the three chromosomes we studied the statistical properties of noncoding regions appear to be closer to those observed in natural languages than those of coding regions. In particular, (i) a n-tuple Zipf analysis of noncoding regions reveals a regime close to power law behavior while the coding regions show logarithmic behavior over a wide interval, while (ii) an n-gram entropy measurement shows that the noncoding regions have a lower n-gram entropy (and hence a larger "n-gram redundancy") than the coding regions. In contrast to the three chromosomes, we find that for vertebrates such as primates and rodents and for viral DNA, the difference between the statistical properties of coding and noncoding regions is not pronounced and therefore the results of the analyses of the investigated sequences are less conclusive. After noting the intrinsic limitations of the n gram redundancy analysis, we also briefly discuss the failure of the zeroth- and first-order Markovian models or simple nucleotide repeats to account fully for these "linguistic" features of DNA. Finally, we emphasize that our results by no means prove the existence of a "language" in noncoding DNA. PMID- 9963742 TI - Proposed physical model for very hot electron shell structures in electron cyclotron resonance-driven plasmas. PMID- 9963743 TI - Two-temperature frequency-dependent electrical resistivity in solid density plasmas produced by ultrashort laser pulses. PMID- 9963745 TI - Rate coefficients of photoionization in hot dense plasmas. PMID- 9963744 TI - Response of the electron density and temperature to the power interruption measured by Thomson scattering in an inductively coupled plasma. PMID- 9963746 TI - Diffusion of atomic hydrogen in an atmospheric-pressure free-burning arc discharge. PMID- 9963747 TI - Collective effects in the energy loss of ion beams in fusion plasmas. PMID- 9963748 TI - Nonlinear electrostatic waves in collisionless plasmas. PMID- 9963750 TI - Ion-acoustic nonlinear periodic waves in a two-electron-temperature plasma. PMID- 9963751 TI - Small-signal analysis of coherent multimode coupling and optical guiding in a Raman free-electron laser. PMID- 9963749 TI - Ball lightning as an example of a magnetohydrodynamic equilibrium. PMID- 9963753 TI - Coherent beam-beam interaction with four colliding beams. PMID- 9963752 TI - Enhanced optical klystron gain with a multiharmonic wiggler. PMID- 9963754 TI - Self-consistent simulation studies of periodically focused intense charged particle beams. PMID- 9963755 TI - Scattering of partially coherent electromagnetic fields by microstructured media. PMID- 9963756 TI - Sorting approach to magnetic random errors. PMID- 9963757 TI - Polarization instabilities in birefringent fibers: A comparison between continuous waves and solitons. PMID- 9963758 TI - Experimental test of the diffusion approximation for multiply scattered sound. PMID- 9963759 TI - Multiple scattering of classical waves in systems with liquidlike correlations: Formulation as a liquid-state theory. PMID- 9963760 TI - Frequency dependence of the penetration of electromagnetic fields through a small coupling hole in a thick wall. PMID- 9963761 TI - Nature of Schott corrections. PMID- 9963762 TI - Rotating ring-shaped bright solitons. PMID- 9963763 TI - Symmetry properties and exact patterns in birefringent optical fibers. PMID- 9963764 TI - Asymptotic wave-wave processes beyond cascading in quadratic nonlinear optical materials. PMID- 9963765 TI - Harmonic generation, induced nonlinearity, and optical bistability in nonlinear composites. PMID- 9963766 TI - Order-N method for force calculation in many-dislocation systems. PMID- 9963767 TI - Physical models as tests of randomness. PMID- 9963768 TI - Nonergodicity, accelerator modes, and asymptotic quadratic-in-time diffusion in a class of volume-preserving maps. PMID- 9963769 TI - Hyperscaling in the Domany-Kinzel cellular automaton. PMID- 9963770 TI - Convergence of continued-fraction representation for the Green's function in the Hubbard model. PMID- 9963771 TI - Interfacial kinetic roughening with correlated noise. PMID- 9963772 TI - Bistable kinetic model driven by correlated noises: Unified colored-noise approximation. PMID- 9963773 TI - Punctuated-equilibrium model of biological evolution is also a self-organized criticality model of earthquakes. PMID- 9963775 TI - Chaos, noise, and synchronization reconsidered. PMID- 9963774 TI - Dynamic behavior of the critical 2( PMID- 9963777 TI - Multiple-scale perturbation analysis of the direct interaction approximation for inertial-range turbulence. PMID- 9963776 TI - Intermittency, the second-order structure function, and the turbulent energy dissipation rate. PMID- 9963779 TI - Structure of the stochastic layer of a perturbed resonant triad. PMID- 9963778 TI - Stieltjes integral representation of effective diffusivities in time-dependent flows. PMID- 9963780 TI - Slow dynamics of segregation in hydrogen-bonded polymer blends. PMID- 9963782 TI - Kinetic and thermodynamic definitions of the critical nucleus in nucleation theory. PMID- 9963781 TI - Association in a Lennard-Jones fluid from a second-order Percus-Yevick equation. PMID- 9963784 TI - Dynamics of growing interfaces in porous media with viscous fingering. PMID- 9963783 TI - Light scattering from the L3 (sponge) phase: Evidence against logarithmic corrections to ideal scaling. PMID- 9963785 TI - Theory of field-gradient NMR diffusometry of polymer segment displacements in the tube-reptation model. PMID- 9963786 TI - Delayed random walks. PMID- 9963787 TI - Response of plasma electrons to a spatially embedded electric field impulse. PMID- 9963788 TI - Variational principle for the asymptotic speed of fronts of the density-dependent diffusion-reaction equation. PMID- 9963789 TI - Simulation studies of pressure and density wave propagations in vertically vibrated beds of granules. PMID- 9963790 TI - Comment on "Equation of state and phase diagrams for dense multi-ionic mixture plasmas" PMID- 9963791 TI - Reply to "Comment on 'Equation of state and phase diagrams for dense multi-ionic mixture plasmas' " PMID- 9963792 TI - Erratum: Reunion and survival of interacting walkers PMID- 9963793 TI - Non-Poisson statistics of reactive events and nonexponential kinetics. PMID- 9963794 TI - Controlling chaos by pinning neurons in a neural network. PMID- 9963795 TI - Distributions of self-interactions and voids in (1+1)-dimensional directed percolation. PMID- 9963796 TI - Dynamic scaling: Distinguishing self-organized from generically critical systems. PMID- 9963797 TI - Chaoticity spectrum in Hamiltonian systems with many degrees of freedom. PMID- 9963798 TI - Modified method for synchronizing and cascading chaotic systems. PMID- 9963799 TI - Surmounting a fluctuating double well: A numerical study. PMID- 9963800 TI - Spontaneous polarization parallel to the tilt plane in the antiferroelectric chiral smectic-CA phase of liquid crystals as observed by polarized infrared spectroscopy. PMID- 9963801 TI - Critical fluctuations near the smectic-A-smectic-C transition of a partially perfluorinated compound. PMID- 9963802 TI - Double layer relaxation at rough electrodes. PMID- 9963804 TI - Long-range anticorrelations and non-Gaussian behavior of a leaky faucet. PMID- 9963803 TI - Molecular ordering of precursor films during spreading of tiny liquid droplets. PMID- 9963805 TI - Attraction of charged particulates in plasmas with finite flows. PMID- 9963806 TI - Interaction of an electron beam with nonuniform gas flow. PMID- 9963807 TI - Transverse instabilities for multiple nonrigid bunches in a storage ring. PMID- 9963809 TI - Range of spectral correlations in pseudointegrable systems: Gaussian-orthogonal ensemble statistics in a rectangular membrane with a point scatterer. PMID- 9963808 TI - Soliton pinning by long-range order in aperiodic systems. PMID- 9963810 TI - Quantum resonance in an intrinsically degenerate system: Nonlinear cyclotron resonance. PMID- 9963811 TI - Experimental control of a chaotic pendulum with unknown dynamics using delay coordinates. PMID- 9963812 TI - Solution moment stability in stochastic differential delay equations. PMID- 9963813 TI - Systematic adiabatic analysis of a nonlinear oscillator with inertia driven by colored noise. PMID- 9963814 TI - One-dimensional quantum random walk for fermions and bosons. PMID- 9963815 TI - Stochastic dynamics of gravity in one dimension. PMID- 9963816 TI - Interface roughening in systems with quenched disorder. PMID- 9963818 TI - Statistics for mathematical properties of maps between time series embeddings. PMID- 9963817 TI - Conditions for synchronization in Josephson-junction arrays. PMID- 9963819 TI - Ergodic property of a Henon-Heiles model with reflecting walls. PMID- 9963820 TI - Lack of universality in two-dimensional multicomponent spreading phenomena. PMID- 9963821 TI - Kinetics of catalytic reactions with diffusional relaxation. PMID- 9963823 TI - Lack of self-averaging in critical disordered systems. PMID- 9963822 TI - Theory of the absorption probability density of diffusing particles in the presence of a dynamic trap. PMID- 9963824 TI - Optimal finite-time endoreversible processes. PMID- 9963825 TI - Equations of state of a dilute gas under a heat flux. PMID- 9963826 TI - Heat generation required by information erasure. PMID- 9963828 TI - Bifurcations and pattern formation in a two-dimensional Navier-Stokes fluid. PMID- 9963827 TI - Dynamic multiscaling of the reaction-diffusion front for mA+nB-->0. PMID- 9963829 TI - Bethe ansatz solution for crossover scaling functions of the asymmetric XXZ chain and the Kardar-Parisi-Zhang-type growth model. PMID- 9963830 TI - Chaotic scattering theory, thermodynamic formalism, and transport coefficients. PMID- 9963831 TI - Multiparameter control of chaos. PMID- 9963832 TI - Suppression and creation of chaos in a periodically forced Lorenz system. PMID- 9963833 TI - Block-analyzing method in cellular automata. PMID- 9963834 TI - Role of percolation in diffusion on random lattices. PMID- 9963835 TI - Evolution of randomly perturbed Korteweg-de Vries solitons. PMID- 9963836 TI - Structure of variational principles in nonequilibrium thermodynamics. PMID- 9963837 TI - Resonant islands without separatrix chaos. PMID- 9963838 TI - Cooperative effects in the nonlinearly driven spin-boson system. PMID- 9963840 TI - Analog simulation of stochastic systems in a metastable piecewise quasilinear potential driven by band-limited white noise. PMID- 9963839 TI - Coin tossing as a billiard problem. PMID- 9963842 TI - Pressure of the hard-sphere solid. PMID- 9963841 TI - Dependence of the diffusion coefficient on the energy distribution of random barriers. PMID- 9963843 TI - Dissipation in quantum physics. PMID- 9963844 TI - Breathing and wiggling motions in three-species laterally inhibitory systems. PMID- 9963845 TI - Scaling and intermittency in Burgers turbulence. PMID- 9963846 TI - Formation of wrinkles in outwardly propagating flames. PMID- 9963847 TI - Effect of a shear flow on the planform of thermal convection in a fluid of variable viscosity. PMID- 9963849 TI - Coupled Burgers equations: A model of polydispersive sedimentation. PMID- 9963848 TI - Small Froude number asymptotics in two-dimensional two-phase flows. PMID- 9963851 TI - Calculation of effective interaction potentials from radial distribution functions: A reverse Monte Carlo approach. PMID- 9963850 TI - Scaling properties of numerical two-dimensional turbulence. PMID- 9963852 TI - Multicomponent turbulence, the spherical limit, and non-Kolmogorov spectra. PMID- 9963853 TI - Nonequilibrium effects in model reactive systems: The role of species temperatures. PMID- 9963854 TI - Transport properties in a binary mixture under shear flow. PMID- 9963856 TI - Non-Gaussian probability distribution of a velocity field in uniform straining flow turbulence. PMID- 9963855 TI - Domain growth in computer simulations of segregating two-dimensional binary fluids. PMID- 9963857 TI - Renormalization for reaction-front propagation in a fully developed turbulent shear flow. PMID- 9963858 TI - Exact resummations in the theory of hydrodynamic turbulence. I. The ball of locality and normal scaling. PMID- 9963859 TI - Exact resummations in the theory of hydrodynamic turbulence. II. A ladder to anomalous scaling. PMID- 9963860 TI - Orientational wetting layer of semiflexible polymers near a hard wall. PMID- 9963861 TI - Smectic-A and smectic-A2 phases in aligned cylinders with a cylindrical attractive square well at one end. PMID- 9963862 TI - Phase-excitation spectrum of ferroelectric liquid crystals in an external static electric field. PMID- 9963863 TI - Computer simulation of domain growth in ferroelectric liquid crystals. PMID- 9963864 TI - Effects of grafting geometry and solvent quality on the structure of bimodal polymer brushes. PMID- 9963865 TI - Supersaturated electrolyte solutions: Theory and experiment. PMID- 9963866 TI - Transient grating in a ferrofluid under magnetic field: Effect of magnetic interactions on the diffusion coefficient of translation. PMID- 9963867 TI - Conformation-space renormalization of randomly branched polymers. PMID- 9963868 TI - Second approximation coefficient for the binary distribution function of ions for the primitive model of an electrolyte solution. PMID- 9963869 TI - Flow of simple liquids down narrow ssV grooves. PMID- 9963871 TI - Sponge-lamellar instability of fluctuating membranes. PMID- 9963870 TI - Dirac chains in the presence of hairpins. PMID- 9963873 TI - Shear-induced phase separation of complex fluids: The role of flow-concentration coupling. PMID- 9963872 TI - Shear flow in the infinite-shear-rate limit. PMID- 9963874 TI - Glass transition in confined geometry. PMID- 9963876 TI - Brownian motion of colloidal particles in a model porous medium. PMID- 9963875 TI - Fast dynamics of glass-forming glycerol. PMID- 9963877 TI - Phase diagrams of nearly-hard-sphere binary colloids. PMID- 9963878 TI - Orientational dependence of the interfacial tension in the adhesive-sphere system. PMID- 9963879 TI - Steady states for viscous fingers with anisotropic surface tension. PMID- 9963880 TI - Irreversible diffusion-limited cluster aggregation: The behavior of the scattered intensity. PMID- 9963881 TI - Singularities and avalanches in interface growth with quenched disorder. PMID- 9963882 TI - Scaling properties of driven interfaces in disordered media. PMID- 9963883 TI - Crack instabilities of a heated glass strip. PMID- 9963884 TI - Inhomogeneous fluid membranes: Segregation, ordering, and effective rigidity. PMID- 9963885 TI - Critical adsorption in the undersaturated regime. PMID- 9963886 TI - Testing mode-coupling theory for a supercooled binary Lennard-Jones mixture. II. Intermediate scattering function and dynamic susceptibility. PMID- 9963887 TI - Brownian dynamics simulation of dense binary colloidal mixtures. I. Structural evolution and dynamics. PMID- 9963888 TI - Brownian dynamics simulation of dense binary colloidal mixtures. II. Translational and bond-orientational order. PMID- 9963889 TI - Nonlinear dc electrical response in a bilayer lipid membrane: Effect of bathing solutions. PMID- 9963890 TI - Chemical amplifier, self-ignition mechanism, and amoeboid cell migration. PMID- 9963891 TI - Driven transport of fluid vesicles through narrow pores. PMID- 9963893 TI - Model simulations of DNA dynamics. PMID- 9963892 TI - Gaussian random energy model and Dyson's model for the origin of metabolism. PMID- 9963894 TI - On-line learning in soft committee machines. PMID- 9963896 TI - Hydrodynamics and dynamic fluctuations of fluid membranes. PMID- 9963895 TI - Effect of vesicle size on the heat capacity anomaly at the gel to liquid crystalline phase transition in unilamellar vesicles of dimyristoylphosphatidylcholine. PMID- 9963898 TI - Modified Fokker-Planck approach to steady-state distributions in plasmas. PMID- 9963897 TI - Counterstreaming electrons and ions in Pierce-like diodes. PMID- 9963899 TI - Generalized relaxation theory and vortices in plasmas. PMID- 9963900 TI - Longitudinal and transverse diffusion coefficients for Li+ ion swarms in Kr gas. PMID- 9963902 TI - Steady-state magnetic field in the Alfven resonance region. PMID- 9963901 TI - Electron-ion equilibration in a strongly coupled plasma. PMID- 9963903 TI - van der Pol behavior of relaxation oscillations in a periodically driven thermionic discharge. PMID- 9963904 TI - C VI Lyman line profiles from 10-ps KrF-laser-produced plasmas. PMID- 9963905 TI - High-gradient acceleration of electrons in a plasma-loaded wiggler. PMID- 9963906 TI - Schottky noise in a laser-cooled ion beam. PMID- 9963907 TI - Coupling impedances of small discontinuities: A general approach. PMID- 9963908 TI - Optical diffusion imaging using a direct inversion method. PMID- 9963909 TI - Cyclotron motion of two Coulombically interacting ion clouds with implications to Fourier-transform ion cyclotron resonance mass spectrometry. PMID- 9963910 TI - Focus wave mode solutions of the inhomogeneous n-dimensional scalar wave equation. PMID- 9963911 TI - Reversible axial segregation of rotating granular media. PMID- 9963912 TI - Nonlinear pulse propagation in twin-core-fiber rocking filters. PMID- 9963913 TI - Variational calculations for thermal combustion waves. PMID- 9963914 TI - Dynamic stability of one-dimensional models of fracture. PMID- 9963915 TI - Diffraction-free field in a planar nonlinear waveguide. PMID- 9963916 TI - Exact, E=0, classical solutions for general power-law potentials. PMID- 9963917 TI - Granular materials under vibration: Simulations of rotating spheres. PMID- 9963918 TI - Analysis of nonuniform gratings. PMID- 9963919 TI - Transition from stationary to traveling localized patterns in a two-dimensional reaction-diffusion system. PMID- 9963920 TI - Interaction of solitons with a strong inhomogeneity in a nonlinear optical fiber. PMID- 9963921 TI - Application of the central-particle-potential approximation for percolation in interacting systems. PMID- 9963922 TI - Selective relaxation method for numerical solution of Schrodinger problems. PMID- 9963923 TI - Transition probability calculations for atoms using nonorthogonal orbitals. PMID- 9963924 TI - Brownian motion in a singular potential and a fractal renewal process. PMID- 9963925 TI - Chaotic behavior of renormalization flow in a complex magnetic field. PMID- 9963927 TI - Critical behavior for the onset of type-III intermittency observed in an electronic circuit. PMID- 9963928 TI - Relaxation, noise-induced transitions, and stochastic resonance driven by non Markovian dichotomic noise. PMID- 9963926 TI - Effect of symmetry breaking on two-dimensional random walks. PMID- 9963930 TI - Cooperativity and hydrogen bond network lifetime in liquid water. PMID- 9963929 TI - Critical dynamics of the open Ising chain. PMID- 9963931 TI - Free thermal convection driven by nonlocal effects. PMID- 9963932 TI - Large-scale properties of wave turbulence. PMID- 9963934 TI - Structure factors of binary fluids in a dilute gel. PMID- 9963933 TI - Phase transitions in finite-thickness nematic liquid-crystal films: Planar anchoring. PMID- 9963935 TI - Addition polymerization in a nematic medium: Effects of an anisotropic solvent in a kinetic gelation model. PMID- 9963936 TI - Dynamic determination of the dendritic growth direction within a complex-phase field model. PMID- 9963937 TI - Maximum entropy, pseudoinverse techniques, and time series predictions with layered networks. PMID- 9963938 TI - Statistical mechanics of neocortical interactions: Constraints on 40-Hz models of short-term memory. PMID- 9963939 TI - Self-sustained plasma waveguide structures produced by ionizing laser radiation in a dense gas. PMID- 9963940 TI - Spherical ion kinetic simulations of DT implosions. PMID- 9963941 TI - Electron collisionless layers near evaporating plasma-heated anodes. PMID- 9963942 TI - Phase problem associated with the determination of the longitudinal shape of a charged particle bunch from its coherent far-ir spectrum. PMID- 9963943 TI - Fisher information and bounds to the entropy increase. PMID- 9963944 TI - Comment on "Oscillation mode and 'nonlinear' radiation of the double sine-Gordon 2 pi kink" PMID- 9963945 TI - Reply to "Comment on 'Oscillation mode and "nonlinear" radiation of the double sine-Gordon 2 pi kink' " PMID- 9963946 TI - Erratum: Transport properties of solitons PMID- 9963947 TI - Mutation accumulation and the catastrophic senescence of the Pacific salmon. PMID- 9963948 TI - Intermingled basins and two-state on-off intermittency. PMID- 9963949 TI - Nonextensive thermostatistics can yield apparent magnetism. PMID- 9963950 TI - Aperiodic stochastic resonance in excitable systems. PMID- 9963951 TI - Scaling behavior of response times of electrorheological suspensions with cation exchange resin particles. PMID- 9963952 TI - Influence of an impenetrable interface on a polymer glass-transition temperature. PMID- 9963953 TI - Grain growth from homogeneous initial conditions: Anomalous grain growth and special scaling states. PMID- 9963954 TI - Numerical results for the ground-state interface in a random medium. PMID- 9963955 TI - Scaling in late stage spinodal decomposition with quenched disorder. PMID- 9963956 TI - Nature of environmentally assisted fracture nucleation and crack growth in polycrystals. PMID- 9963957 TI - Derivation of the inertial ac response for the Kerr-effect relaxation from the Langevin equation in three-dimensional space. PMID- 9963958 TI - Small-fluctuation expansion of the transition probability for a diffusion process. PMID- 9963959 TI - 1/f noise in a two-lane highway traffic model. PMID- 9963960 TI - Exits in multistable systems excited by coin-toss square-wave dichotomous noise: A chaotic dynamics approach. PMID- 9963961 TI - Transient statistics in stabilizing periodic orbits. PMID- 9963962 TI - Perimeter-area laws for a random agglomeration of particles. PMID- 9963963 TI - Statistical mechanics of metastable matter: Superheated and stretched liquids. PMID- 9963964 TI - Stochastic resonance and the dithering effect in threshold physical systems. PMID- 9963966 TI - Dissipative quantum systems with a potential barrier. II. Dynamics near the barrier top. PMID- 9963965 TI - Ordering kinetics of conserved XY models. PMID- 9963967 TI - Biscale chaos in propagating fronts. PMID- 9963968 TI - Mixed dynamics and tunneling. PMID- 9963970 TI - Noise-induced stabilization of the Lorenz system. PMID- 9963969 TI - Improved perturbation theory for the Kardar-Parisi-Zhang equation. PMID- 9963972 TI - Topological characterization of a system with high-order symmetries. PMID- 9963971 TI - Approximately conserved quantity in the Henon-Heiles problem. PMID- 9963973 TI - Quantum chaos, degeneracies, and exceptional points. PMID- 9963975 TI - Gaussian random-matrix process and universal parametric correlations in complex systems. PMID- 9963974 TI - Search for a Kosterlitz-Thouless transition in a triangular Ising antiferromagnet with further-neighbor ferromagnetic interactions. PMID- 9963977 TI - Structure of avalanches and breakdown of simple scaling in the Abelian sandpile model in one dimension. PMID- 9963976 TI - Self-consistent chaos and Arnold diffusion in a cyclotron-maser wave-particle system. PMID- 9963978 TI - Lyapunov spectrum of the driven Lorentz gas. PMID- 9963980 TI - Dyson-Schwinger loop equations of the two-matrix model: Correlations in quantum chaos. PMID- 9963979 TI - log-periodic behavior of a hierarchical failure model with applications to precursory seismic activation. PMID- 9963981 TI - Scaling of energy barriers for flux lines and other random systems. PMID- 9963982 TI - Renormalization-group analysis of a noisy Kuramoto-Sivashinsky equation. PMID- 9963984 TI - Predictive Poincare control: A control theory for chaotic systems. PMID- 9963983 TI - Finite-size correction in a disordered system: A new divergence. PMID- 9963985 TI - Kinetic theory of multicomponent dense mixtures of slightly inelastic spherical particles. PMID- 9963987 TI - Viscous conducting flows with smooth-particle applied mechanics. PMID- 9963986 TI - Multiple-scattering theory of excess electrons in simple fluids. PMID- 9963989 TI - Normal and anomalous scaling of the fourth-order correlation function of a randomly advected passive scalar. PMID- 9963988 TI - Anomalous separation of homogeneous particle-fluid mixtures: Further observations. PMID- 9963990 TI - Diffusion in a gaseous dilute solution under heat and momentum transport. PMID- 9963991 TI - Hydrodynamic dispersion at stagnation points: Simulations and experiments. PMID- 9963992 TI - Spatiotemporal chaos in a model of Rayleigh-Benard convection. PMID- 9963993 TI - Theoretical studies of sonoluminescence radiation: Radiative transfer and parametric dependence. PMID- 9963994 TI - Nematic ordering in a Vycor-like restrictive geometry: A two-dimensional model. PMID- 9963995 TI - Calorimetric study of chiral liquid crystals with a twist-grain-boundary phase. PMID- 9963997 TI - Order parameter measurements from the Kossel diagrams of the liquid-crystal blue phases. PMID- 9963996 TI - Fast relaxation mode in a thermotropic uniaxial nematic liquid crystal. PMID- 9963999 TI - Surface-induced alignment at model nematic interfaces. PMID- 9963998 TI - Wetting and layering transitions in liquid crystals. PMID- 9964000 TI - Theory of the phase diagrams of lyotropic nematic and lyotropic cholesteric systems. PMID- 9964002 TI - Random copolymers as effective compatibilizing agents. PMID- 9964001 TI - Lagrangian approach to light propagation in liquid crystals. PMID- 9964003 TI - Modeling of metal electrodeposits: Analytical solutions. PMID- 9964004 TI - Short-time Brownian motion in colloidal suspensions: Experiment and simulation. PMID- 9964005 TI - Critical behavior of randomly branched polymers with quenched branchings. PMID- 9964006 TI - Orientational glass transition in a rotator model. PMID- 9964007 TI - Control of self-replicating patterns in a model reaction-diffusion system. PMID- 9964009 TI - Finite-time vortex singularity and Kolmogorov spectrum in a symmetric three dimensional spiral model. PMID- 9964008 TI - High-temperature dynamics in glass-forming liquids. PMID- 9964010 TI - Fracture modes in a triangular lattice crystal: Numerical and phenomenological studies. PMID- 9964011 TI - Mean-field theory of the morphology transition in stochastic diffusion-limited growth. PMID- 9964012 TI - Tricontinuous structure in a homopolymer-homopolymer-random-copolymer ternary mixture quenched under the tricritical point. PMID- 9964014 TI - Laplacian growth of amorphous carbon filaments in a non-diffusion-limited experiment. PMID- 9964013 TI - Polymer-induced ordering in water-oil-surfactant mixtures. PMID- 9964015 TI - Frequency dependence of aggregation in two-dimensional colloidal systems. PMID- 9964016 TI - Temporal scaling of interfaces propagating in porous media. PMID- 9964017 TI - Orientational ordering of polymers on a fluctuating flexible surface. PMID- 9964019 TI - Computer simulation and six-dimensional spin density and velocity NMR microimaging of lacunar systems: A comparative analysis of percolation properties. PMID- 9964018 TI - Classical model for energy transfer in microspherical droplets. PMID- 9964020 TI - Effect of polymer nonideality in a colloid-polymer mixture. PMID- 9964022 TI - Microscopic description of nematic liquid crystal viscosity. PMID- 9964021 TI - Linear polymers with competing interactions: Swollen linear, swollen branched, and compact scaling regimes. PMID- 9964025 TI - Fixed points in a Hopfield model with random asymmetric interactions. PMID- 9964024 TI - Dynamics of phase separation in copolymer-homopolymer mixtures. PMID- 9964023 TI - Light-scattering study of phase transitions in aqueous solutions of nonionic amphiphiles. PMID- 9964026 TI - Introducing a real time scale into the Bak-Sneppen model. PMID- 9964027 TI - Dynamical model for DNA sequences. PMID- 9964028 TI - Lattice-gas model for collective biological motion. PMID- 9964030 TI - Polarized supersonic plasma flow simulation for charged bodies such as dust particles and spacecraft. PMID- 9964029 TI - Dynamic processing of SiH4+CH4 plasma induced by an infrared laser. PMID- 9964031 TI - Self-resonant plasma wake-field excitation by a laser pulse with a steep leading edge for particle acceleration. PMID- 9964033 TI - Electromagnetic localized waves that counteract Coulomb repulsion to catalyze a collective electron-packet state. PMID- 9964034 TI - Richtmyer-Meshkov mixing zone study by a multidirectional laser absorption technique. PMID- 9964032 TI - Minima of the orientation phenomena for direct s-p electron-ion excitations in dense plasmas. PMID- 9964035 TI - Equation of state and transport properties of an interacting multispecies plasma: Application to a multiply ionized Al plasma. PMID- 9964036 TI - Thermodynamic and transport properties of dense hydrogen plasmas. PMID- 9964037 TI - Energy spectrum of hydrogen atoms in dense plasmas. PMID- 9964038 TI - Nonlinear theory of short-wavelength free-electron lasers. PMID- 9964039 TI - Nondestructive diagnostics for relativistic picosecond bunched electron beams. PMID- 9964040 TI - Thomson scattering of intense lasers from electron beams at arbitrary interaction angles. PMID- 9964042 TI - Spectrum formula of the synchrotron radiation from a quasiperiodic undulator. PMID- 9964041 TI - Laser acceleration of electrons in vacuum. PMID- 9964043 TI - Spectral dynamics of a free-electron maser with a step-tapered undulator. PMID- 9964045 TI - Fast beam-ion instability. I. Linear theory and simulations. PMID- 9964044 TI - Analytical theory of short-pulse free-electron laser oscillators. PMID- 9964046 TI - Fast beam-ion instability. II. Effect of ion decoherence. PMID- 9964047 TI - Theoretical definitions of length and charge and second-order electric fields from steady currents. PMID- 9964048 TI - Generation and evolution of two-dimensional dark spatial solitons. PMID- 9964050 TI - Invariance properties of random pulses and of other random fields in dispersive media. PMID- 9964049 TI - One-dimensional transport-induced instabilities in an optical system with nonlocal feedback. PMID- 9964051 TI - Surfaces of bifurcation in a triparametric quadratic Hamiltonian. PMID- 9964053 TI - Stick-slip dynamics of a one-dimensional array of particles. PMID- 9964052 TI - Analytic criterion for soliton instability in a nonlinear fiber array. PMID- 9964055 TI - Kink soliton characterizing traffic congestion. PMID- 9964054 TI - Soliton interaction and stability in nonlinear directional fiber couplers. PMID- 9964056 TI - Fluidization of a two-dimensional granular system: Experimental study and scaling behavior. PMID- 9964058 TI - Parallel diffusion-limited aggregation. PMID- 9964057 TI - Energy input and scaling laws for a single particle vibrating in one dimension. PMID- 9964060 TI - Compound-Poisson-process method for the multiple scattering of charged particles. PMID- 9964059 TI - Simple model for river network evolution. PMID- 9964061 TI - Operational conditions for random-number generation. PMID- 9964062 TI - Method for solving the gyrokinetic Poisson equation in general geometry. PMID- 9964063 TI - Simple proof of Page's conjecture on the average entropy of a subsystem. PMID- 9964064 TI - Variational path-integral approach to a nonlinear open system. PMID- 9964065 TI - Frustration: How it can be measured. PMID- 9964066 TI - Dynamic scaling behavior of an interacting monomer-dimer model. PMID- 9964067 TI - Band structure of the Hamiltonian matrix of a real "chaotic" system: The Ce atom. PMID- 9964068 TI - Sequential partitioning: An alternative to understanding size distributions of avalanches in first-order phase transitions. PMID- 9964069 TI - Quasidynamic model for earthquake simulations. PMID- 9964070 TI - Conditional averaging of a turbulent free surface. PMID- 9964072 TI - Attractive interaction between pulses in a model for convection in binary mixtures. PMID- 9964071 TI - Kolmogorov turbulence in a random-force-driven Burgers equation: Anomalous scaling and probability density functions. PMID- 9964073 TI - Shock waves in a dense gas. PMID- 9964074 TI - Crossover integral-equation theory for the structure of simple liquid metals. PMID- 9964075 TI - Scaling behavior of pinning in polymerization-induced phase separation. PMID- 9964076 TI - Self-organized criticality in coevolving interacting systems. PMID- 9964077 TI - Polarization characteristics of spontaneous emission and off-axis coherent gain in a free-electron laser. PMID- 9964078 TI - Coherent stochastic resonance in the presence of a field. PMID- 9964079 TI - Reply to "Coherent stochastic resonance in the presence of a field" PMID- 9964080 TI - Comment on "Ability of nonperturbative density-functional theories to stabilize arbitrary solids" PMID- 9964081 TI - Erratum: Diagnostics of plasmas with substantial concentrations of atomic oxygen PMID- 9964082 TI - Self-organized criticality in a sandpile model with threshold dissipation. PMID- 9964083 TI - Eigenmodes of decay and fragmentation processes. PMID- 9964084 TI - Generalized entropies in a turbulent dynamo simulation. PMID- 9964086 TI - Inertial range scaling of intense events in turbulence. PMID- 9964085 TI - Competing patterns in the Faraday experiment. PMID- 9964087 TI - Behavior of a surface phase transition in freely suspended liquid-crystal films. PMID- 9964088 TI - Chemically frozen phase separation in an adsorbed layer. PMID- 9964089 TI - High-frequency dielectric properties of aerosol sodium bis-2-ethyl hexylsulfosuccinate (AOT)-H2O-CCl4 systems in the reversed micellar phase. PMID- 9964090 TI - Learning from noisy data: An exactly solvable model. PMID- 9964091 TI - Breatherlike impurity modes in discrete nonlinear lattices. PMID- 9964093 TI - Smoluchowski approach for three-body reactions in one dimension. PMID- 9964092 TI - Hysteresis in the Mott transition between plasma and insulating gas. PMID- 9964094 TI - Using noise and chaos control to control nonchaotic systems. PMID- 9964095 TI - First-passage time for randomly flashing diffusion. PMID- 9964096 TI - Controlling a chaotic array of pulse-coupled circuits. PMID- 9964097 TI - Critical edge between frozen extinction and chaotic life. PMID- 9964098 TI - Fourier transform method to determine the probability density function from a given set of random samples. PMID- 9964100 TI - Vicious walkers and directed polymer networks in general dimensions. PMID- 9964099 TI - Steady states, invariant measures, and response theory. PMID- 9964102 TI - Segregation in the static pair annihilation process: Exact results. PMID- 9964101 TI - Control of dissipative tunneling dynamics by continuous wave electromagnetic fields: Localization and large-amplitude coherent motion. PMID- 9964103 TI - Modeling of wind-blown sand using cellular automata. PMID- 9964104 TI - Phenomenological approach to nonlinear Langevin equations. PMID- 9964105 TI - Approach to ergodicity in quantum wave functions. PMID- 9964106 TI - Trigger waves in a model for catalysis. PMID- 9964107 TI - Noise-induced transition from anomalous to ordinary diffusion: The crossover time as a function of noise intensity. PMID- 9964108 TI - Statistical mechanics of closed fluid membranes. PMID- 9964109 TI - Thermal and repulsive traffic flow. PMID- 9964110 TI - Reentrant phase diagram of branching annihilating random walks with one and two offspring. PMID- 9964111 TI - Level repulsion in the complex plane. PMID- 9964113 TI - Traffic flow and 1/f fluctuations. PMID- 9964112 TI - Interaction of spiral waves with external fields in excitable media. PMID- 9964114 TI - Ordering and demixing transitions in multicomponent Widom-Rowlinson models. PMID- 9964115 TI - Generalized monomer-monomer model for catalysis. PMID- 9964116 TI - Critical and scaling properties of cluster distributions in nonequilibrium Ising like systems. PMID- 9964117 TI - Dynamics of adsorption-desorption processes as a soluble problem of many fermions. PMID- 9964118 TI - Breakdown of linear dynamics in phase-ordering kinetics. PMID- 9964119 TI - Correlations in Ising chains with nonintegrable interactions. PMID- 9964121 TI - Theoretical and numerical studies of chemisorption on a line with precursor layer diffusion. PMID- 9964120 TI - Fragmentation-inactivation models with mass loss. PMID- 9964122 TI - Matrix-inversion method: Applications to Mobius inversion adn deconvolution. PMID- 9964123 TI - Kinetics of aggregation-annihilation processes. PMID- 9964124 TI - Resonant behavior of a Poisson process driven by a periodic signal. PMID- 9964125 TI - Phase-ordering kinetics with external fields and biased initial conditions. PMID- 9964127 TI - Role of inviscid invariants in shell models of turbulence. PMID- 9964126 TI - Multistability and chaos in a spring-block model. PMID- 9964128 TI - Linear and nonlinear viscous flow in two-dimensional fluids. PMID- 9964130 TI - Bifurcations at the Eckhaus points in two-dimensional Rayleigh-Benard convection. PMID- 9964129 TI - Contribution of particle inertial effects to resonance in ferrofluids. PMID- 9964132 TI - Fingering instability in nonadiabatic low-Lewis-number flames. PMID- 9964131 TI - Formation of thermal plumes in an autocatalytic exothermic chemical reaction. PMID- 9964133 TI - Rayleigh-Benard convection in binary mixtures with separation ratios near zero. PMID- 9964134 TI - Transitions between convective patterns in chemical fronts. PMID- 9964135 TI - Turbulence without pressure. PMID- 9964136 TI - Wavelet analysis of the energy transfer caused by convective terms: Application to the Burgers shock. PMID- 9964137 TI - Quantum molecular dynamics simulations of hot, dense hydrogen. PMID- 9964138 TI - Universality of a class of annihilation-coagulation models. PMID- 9964139 TI - Phase transition and defects in a thin nematic film. PMID- 9964140 TI - Covariant elasticity and dislocations in smectic-C liquid crystals. PMID- 9964141 TI - Kink switching in ferroelectric free-standing films with high spontaneous polarization. PMID- 9964142 TI - Temperature-induced orientational transitions in freely suspended nematic films. PMID- 9964145 TI - Interaction in colloidal systems: Buckling and melting. PMID- 9964143 TI - Nonlinear conserved current model with negative diffusion. PMID- 9964144 TI - Viscoelasticity of randomly branched polymers in the critical percolation class. PMID- 9964146 TI - Thermal fluctuations of the shapes of droplets in dense and compressed emulsions. PMID- 9964147 TI - Distributions of polymers in disordered structures. PMID- 9964149 TI - Continuously varying crossover exponent for adsorption of linear polymers on fractals. PMID- 9964148 TI - Surface growth of two kinds of particle deposition models. PMID- 9964150 TI - Cavity size distribution in lattice liquids. PMID- 9964152 TI - Frequency dependence of electrorheological fluids in an ac electric field. PMID- 9964151 TI - Time-scale dependence of the critical exponent for the nonlinear dielectric effect in a critical binary solution. PMID- 9964153 TI - Forced Benjamin-Ono equation and its application to soliton dynamics. PMID- 9964154 TI - Long-time self-diffusion in binary colloidal hard-sphere dispersions. PMID- 9964156 TI - Dynamics of binary liquids in pores. PMID- 9964155 TI - Planform selection in Benard-Marangoni convection: l hexagons versus g hexagons. PMID- 9964157 TI - Microscopic structure of a pure near-critical fluid confined to a mesoscopic slit pore. PMID- 9964158 TI - Pore-level modeling of wetting. PMID- 9964159 TI - Diffusion-limited aggregation: Connection to a free-boundary problem and lattice anisotropy. PMID- 9964161 TI - Kinetics of crystallization in a shearing colloidal suspension. PMID- 9964160 TI - Growth kinetics of body centered cubic colloidal crystals. PMID- 9964162 TI - Monte Carlo study of semiflexible living polymers. PMID- 9964163 TI - Growth of interfaces with strong quenched disorder: Columnar media. PMID- 9964164 TI - Classical growth of hard-sphere colloidal crystals. PMID- 9964165 TI - Sedimentation and flow through porous media: Simulating dynamically coupled discrete and continuum phases. PMID- 9964166 TI - Growth instabilities in mechanical breakdown under mechanical and thermal stresses. PMID- 9964167 TI - Crystal stability limits at positive and negative pressures, and crystal-to-glass transitions. PMID- 9964168 TI - Shear-induced enhancement of self-diffusion in interacting colloidal suspensions. PMID- 9964169 TI - Quantitative molecular interpretation of mesoscopic correlations in bicontinuous microemulsions. PMID- 9964170 TI - Kinetic model for a polymer in one dimension. PMID- 9964171 TI - NMR of diffusing atoms in a periodic porous medium in the presence of a nonuniform magnetic field. PMID- 9964172 TI - Irreversible polymer adsorption from semidilute and moderately dense solutions. PMID- 9964173 TI - Temporal and spatial dependence of hydrodynamic correlations: Simulation and experiment. PMID- 9964174 TI - Actin filaments on myosin beds: The velocity distribution. PMID- 9964175 TI - Statistical-ensemble theory of redundancy reduction and the duality between unsupervised and supervised neural learning. PMID- 9964176 TI - Multifractals and decoded walks: Applications to protein sequence correlations. PMID- 9964177 TI - Role of noises in neural networks. PMID- 9964179 TI - Vesicular instabilities: The prolate-to-oblate transition and other shape instabilities of fluid bilayer membranes. PMID- 9964178 TI - Random-walk model of homologous recombination. PMID- 9964180 TI - Monte Carlo approach to tissue-cell populations. PMID- 9964181 TI - Quantum-mechanical treatment of strong electron-atom collision contributions to the shift and width of hydrogen lines. PMID- 9964182 TI - Test-particle drifts in traveling waves with cyclotron frequencies. PMID- 9964183 TI - Investigation of C V line ratio variations in a tokamak with an application to neutral hydrogen measurement. PMID- 9964184 TI - Self-consistent charged-particle motion in negative-ion plasmas. PMID- 9964185 TI - Interpretation of hot and dense absorption spectra of a near-local-thermodynamic equilibrium plasma by the super-transition-array method. PMID- 9964186 TI - Lateral energy transport in laser-produced plasmas. PMID- 9964188 TI - Dynamics of coherent structures and turbulence of plasma drift waves. PMID- 9964187 TI - Radiative heating of low-Z solid foils by laser-generated x rays. PMID- 9964189 TI - Simulation and analysis of an x-ray-heated boron nitride foil. PMID- 9964190 TI - Transport and self-organization in dissipative drift-wave turbulence. PMID- 9964191 TI - Kinetic theory of ion acoustic waves in a plasma with collisional electrons. PMID- 9964192 TI - Nonlinear theory of a folded waveguide gyrotron traveling-wave tube amplifier. PMID- 9964193 TI - Observation of coherent diffraction radiation from bunched electrons passing through a circular aperture in the millimeter- and submillimeter-wavelength regions. PMID- 9964195 TI - Betatron motion and linear undulator brightness: Inhomogeneous broadening effects due to electron-beam emittance and Twiss parameters. PMID- 9964194 TI - X-ray narrow-line transition radiation source based on low-energy electron beams traversing a multilayer nanostructure. PMID- 9964196 TI - Simulation of an experiment on crystal extraction of 900-GeV protons. PMID- 9964197 TI - Impulse response of a nonlinear dispersive wave. PMID- 9964198 TI - Diffraction of partially coherent beams on three-dimensional periodic structures and the angular shifts of the diffraction maxima. PMID- 9964200 TI - Noise-induced instability in self-consistent Monte Carlo calculations. PMID- 9964199 TI - Estimating functions of probability distributions from a finite set of samples. PMID- 9964201 TI - Acceptance-probability-controlled simulated annealing: A method for modeling the optical constants of solids. PMID- 9964202 TI - Influence of constraints on the dynamics of polypeptide chains. PMID- 9964203 TI - Density of states of a damped quantum oscillator. PMID- 9964204 TI - Exponential decay of relative entropies to the Kolmogorov-Sinai entropy for the standard map. PMID- 9964205 TI - Chaos and thermal conductivity. PMID- 9964208 TI - Non-Markovian thermal relaxation at elevated temperatures. PMID- 9964206 TI - Unusual period doublings in the linear-logistic map. PMID- 9964207 TI - Two-species annihilation with drift: A model with continuous concentration-decay exponents. PMID- 9964209 TI - Hopf bifurcation in a leaky faucet experiment. PMID- 9964210 TI - Trapping rate dependence on the trap size in one dimension. PMID- 9964212 TI - Numerical simulation of phase separation in the presence of surfactants and hydrodynamics. PMID- 9964213 TI - Electron cyclotron subharmonic resonance absorption. PMID- 9964211 TI - Reptation of a polymer chain by conformal transitions in the entangled regime. PMID- 9964214 TI - Erratum: Phase ordering dynamics of cosmological models PMID- 9964215 TI - Erratum: Lagrangians of physics and the game of Fisher-information transfer PMID- 9964216 TI - Extremal properties of random systems. PMID- 9964217 TI - Parametric resonance of rotating spiral waves under broken rotational symmetry. PMID- 9964218 TI - Transfer matrix for the restricted canonical and microcanonical ensembles. PMID- 9964220 TI - Quantum localization of chaos in a ring. PMID- 9964219 TI - Pattern formation in composite excitable media. PMID- 9964221 TI - Conjugate pairing in the three-dimensional periodic Lorentz gas. PMID- 9964222 TI - Criticality and transient chaos in a sandpile model. PMID- 9964223 TI - Anomalous diffusion of isolated flow singularities and of fractal or spiral structures. PMID- 9964224 TI - Inertial range scaling in turbulence. PMID- 9964226 TI - Dielectric relaxation study in a glassy low-molecular-weight ferroelectric liquid crystal. PMID- 9964227 TI - Coupled fluctuations near critical wetting. PMID- 9964225 TI - Continuous shock structure in extended thermodynamics. PMID- 9964228 TI - Secondary instability in surface-tension-driven Benard convection. PMID- 9964229 TI - Critical dynamics of contact-line motion. PMID- 9964231 TI - Spatially localized, temporally quasiperiodic, discrete nonlinear excitations. PMID- 9964230 TI - Collimation of an intense laser beam by a weakly relativistic plasma. PMID- 9964232 TI - Soliton solutions in Rowland ghost gaps. PMID- 9964233 TI - Molecular dynamics-continuum hybrid computations: A tool for studying complex fluid flows. PMID- 9964234 TI - Transition from strange nonchaotic to strange chaotic attractors. PMID- 9964235 TI - Renormalization group calculation of anomalous exponents for nonlinear diffusion. PMID- 9964236 TI - Finding the windows of regular motion within the chaos of ordinary differential equations. PMID- 9964238 TI - Dynamics of sandpiles: Physical mechanisms, coupled stochastic equations, and alternative universality classes. PMID- 9964237 TI - Adiabatic propagation of distributions: Exactly solvable models. PMID- 9964239 TI - Chaotic states of weakly and strongly nonlinear oscillators with quasiperiodic excitation. PMID- 9964240 TI - Statistical redistribution of trajectories from a torus to tori by chaotic dynamical tunneling. PMID- 9964241 TI - Square lattice with attractive interactions. PMID- 9964243 TI - Growth of breakdown susceptibility in random composites and the stick-slip model of earthquakes: Prediction of dielectric breakdown and other catastrophes. PMID- 9964242 TI - Universal grazing bifurcations in impact oscillators. PMID- 9964244 TI - Etchant and probabilistic ballistic models of diamond growth. PMID- 9964246 TI - Solvable models of spin-1/2 chains with an energy gap. PMID- 9964245 TI - Smooth quantum potential for the hydrodynamic model. PMID- 9964247 TI - Geometric description of chaos in two-degrees-of-freedom Hamiltonian systems. PMID- 9964248 TI - Specific heat of a ferromagnetic film. PMID- 9964249 TI - Control of chaos in multimode solid state lasers by the use of small periodic perturbations. PMID- 9964251 TI - Unified time-path approach to the generating functional of the Brownian oscillator system: The bilinearly corrected Feynman rule for nonequilibrium processes. PMID- 9964250 TI - Smoothed density of states for problems with ray splitting. PMID- 9964252 TI - Analytical approach to coagulation and annihilation of particles with anomalous diffusion. PMID- 9964253 TI - Scaling and universality in the spanning probability for percolation. PMID- 9964254 TI - Complex-temperature properties of the two-dimensional Ising model for nonzero magnetic field. PMID- 9964256 TI - Experimental visualization of acoustic resonances within a stadium-shaped cavity. PMID- 9964255 TI - Stochastic Hopf bifurcation: The effect of colored noise on the bifurcation interval. PMID- 9964258 TI - Evolution of the Liouville density of a chaotic system. PMID- 9964257 TI - Experimental study of fracture surface roughness on rocks with crack velocity. PMID- 9964259 TI - Aggregation with multiple conservation laws. PMID- 9964260 TI - General method of controlling chaos. PMID- 9964261 TI - Formation of pyramids and mounds in molecular beam epitaxy. PMID- 9964262 TI - Interpolating ensembles of random unitary matrices. PMID- 9964263 TI - Stochastic processes with stable distributions in random environments. PMID- 9964264 TI - Damage spreading in the Ising model with a microcanonical constraint. PMID- 9964265 TI - Exact solutions of the monomer-monomer reaction: Segregation, poisoning, and interface evolution. PMID- 9964266 TI - Quantum fluctuations and glassy behavior: The case of a quantum particle in a random potential. PMID- 9964267 TI - Nonequilibrium potential for a reaction-diffusion model: Critical behavior and decay of extended metastable states. PMID- 9964268 TI - Scale invariance and dynamical correlations in growth models of molecular beam epitaxy. PMID- 9964269 TI - Traces of a quantum antiresonance in a driven system. PMID- 9964270 TI - Monte Carlo study of the random-field Ising model. PMID- 9964271 TI - Complex dynamical behavior in RCL-shunted Josephson tunnel junctions. PMID- 9964272 TI - Avalanche dynamics in evolution, growth, and depinning models. PMID- 9964273 TI - Multifractal scaling of moments of mean first-passage time in the presence of Sinai disorder. PMID- 9964274 TI - Nearest-neighbor statistics in a one-dimensional random sequential adsorption process. PMID- 9964275 TI - Low-temperature relaxation in the one-dimensional Ising model. PMID- 9964277 TI - Self-similarity and probability distributions of turbulent intermittency. PMID- 9964276 TI - Einstein crystal as a reference system in free energy estimation using adiabatic switching. PMID- 9964279 TI - Spontaneous regular structure amplification in strongly turbulent rotating fluids. PMID- 9964278 TI - Structure of transport linear systems in dilute isotropic gas mixtures. PMID- 9964280 TI - Foundations and applications of a mesoscopic thermodynamic theory of fast phenomena. PMID- 9964282 TI - Violation of the electroneutrality condition in confined charged fluids. PMID- 9964281 TI - Bifurcations from Taylor vortices between corotating concentric cylinders. PMID- 9964284 TI - Polymer-induced drag reduction in turbulent flows. PMID- 9964283 TI - Nonlinear resonant stimulation and no-feedback control of the wake behind a circular cylinder. PMID- 9964285 TI - Stress fluctuations and shear zones in quasistatic granular chute flows. PMID- 9964286 TI - Terraced spreading mechanisms for chain molecules. PMID- 9964287 TI - Transition between curved and angular textures in binary fluid convection. PMID- 9964288 TI - Analytic expressions for the stochastic amplitude equation for Taylor-Couette flow. PMID- 9964289 TI - Quantum kinetic equation in weak turbulence. PMID- 9964290 TI - Monte Carlo simulation of the ferromagnetic order-disorder transition in a Heisenberg fluid. PMID- 9964291 TI - Relation between information transfer and structure function in shell models. PMID- 9964292 TI - Molecular-dynamics study of detonation. I. A comparison with hydrodynamic predictions. PMID- 9964293 TI - Molecular-dynamics study of detonation. II. The reaction mechanism. PMID- 9964295 TI - Dielectric behavior at the smectic-C*-chiral-nematic phase transition of a ferroelectric liquid crystal. PMID- 9964294 TI - Ellipsometry at the nematic-isotropic phase transition in a confined geometry. PMID- 9964296 TI - Defects in chiral columnar phases: Tilt-grain boundaries and iterated moire maps. PMID- 9964297 TI - Chiral and herringbone symmetry breaking in water-surface monolayers. PMID- 9964298 TI - Optical determination of the twist elastic constant of a smectic-C* liquid crystal. PMID- 9964299 TI - Simple molecular model for induced cholesteric phases. PMID- 9964300 TI - Quench-induced nematic textures of wormlike micelles. PMID- 9964301 TI - Dynamics of helix deformation in a chiral smectic-C* liquid crystal: Optical experiments and modeling. PMID- 9964302 TI - Dynamic critical behavior of thermal parameters at the smectic-A-nematic phase transition of octyloxythiolbenzoate. PMID- 9964303 TI - Oblique anchoring at a free nematic surface. PMID- 9964304 TI - Theory of a critical point in the blue-phase-III-isotropic phase diagram. PMID- 9964305 TI - Viscous properties of binary mixtures of nematic liquid crystals. PMID- 9964306 TI - Computer modeling of electrochemical growth with convection and migration in a rectangular cell. PMID- 9964307 TI - Membrane hydrodynamics at low Reynolds number. PMID- 9964308 TI - Anisotropic diffusion-limited reactions with coagulation and annihilation. PMID- 9964309 TI - Simulation of multicomponent fluids in complex three-dimensional geometries by the lattice Boltzmann method. PMID- 9964310 TI - Fitting of viscosity: Distinguishing the temperature dependences predicted by various models of supercooled liquids. PMID- 9964312 TI - Critical behavior of the dielectric constant in the triethylamine-water binary liquid mixture: Evidence of an intrinsic effect. PMID- 9964311 TI - Continuum model for the growth of interfaces. PMID- 9964313 TI - Kinetics of irreversible adsorption with a particle conformational change: A density expansion approach. PMID- 9964315 TI - Theory of gel electrophoresis in high fields: Transient regimes at the field onset. PMID- 9964314 TI - Enhanced diffusion upon approaching the kinetic glass transition. PMID- 9964317 TI - Model for an associating fluid near an associatively adsorbing crystalline surface. PMID- 9964316 TI - Adsorption of a minority component in polymer blend interfaces. PMID- 9964318 TI - Experimental study of surface segregation and wetting in films of a partially miscible polymer blend. PMID- 9964319 TI - Monte Carlo simulations of a single polymer chain under extension above and below the Theta temperature. PMID- 9964320 TI - Randomly charged polymers, random walks, and their extremal properties. PMID- 9964321 TI - Front stability in mean-field models of diffusion-limited growth. PMID- 9964322 TI - Order and localization in randomly cross-linked polymer networks. PMID- 9964323 TI - Evolution of soap froth under temperature effects. PMID- 9964324 TI - Curvature contributions to the capillary-wave Hamiltonian for a pinned interface. PMID- 9964325 TI - Origin of depolarized light scattering in supercooled liquids: Orientational fluctuation versus induced scattering mechanisms. PMID- 9964327 TI - Influence of surfactants on the structure of titanium oxide gels: Experiments and simulations. PMID- 9964326 TI - Adsorption of multiblock copolymers at interfaces between selective solvents: Single-chain properties. PMID- 9964329 TI - Theoretical study of fluid membranes of spherical topology with internal degrees of freedom. PMID- 9964328 TI - Tricritical universality in a two-dimensional spin fluid. PMID- 9964330 TI - Universal short-time motion of a polymer in a random environment: Analytical calculations, a blob picture, and Monte Carlo results. PMID- 9964332 TI - Sedimentation to form rough, quasi-one-dimensional interfaces. PMID- 9964331 TI - Intermittent behavior in slow drainage. PMID- 9964333 TI - Numerical simulation of cellular tip growth. PMID- 9964334 TI - Topology-preservation emergence by the Hebb rule with infinitesimal short-range signals. PMID- 9964336 TI - Effective breather trapping mechanism for DNA transcription. PMID- 9964335 TI - Elastic vibrations of microtubules in a fluid. PMID- 9964337 TI - Maximum-entropy principle and neural networks that learn to construct approximate wave functions. PMID- 9964338 TI - Dynamic spectral density function of a dusty plasma. PMID- 9964339 TI - Self-consistent charge dynamics in magnetized dusty plasmas: Low-frequency electrostatic modes. PMID- 9964340 TI - Effects of ion dynamics and opacity on Stark-broadened argon line profiles. PMID- 9964341 TI - Nonlinear lower hybrid vortices. PMID- 9964342 TI - Calculation of the electrical conductivity of strongly coupled plasmas. PMID- 9964343 TI - Short pulse laser propagation in underdense plasmas. PMID- 9964344 TI - Collisional-radiative modeling of the L-shell emission of Mo30+ to Mo33+ emitted from a high-temperature-low-density tokamak plasma. PMID- 9964345 TI - Direct Monte Carlo sampling of the short-range screening potentials for classical Coulomb liquids. PMID- 9964346 TI - Nonlinear inverse bremsstrahlung and highly anisotropic electron distributions. PMID- 9964347 TI - Modeling of nonlocal electron kinetics in a low-pressure inductively coupled plasma. PMID- 9964348 TI - Generation of a high-quality electron beam for application in cyclotron autoresonance maser experiments. PMID- 9964349 TI - Channeling process in a bent crystal. PMID- 9964350 TI - One-dimensional spatial solitary waves due to cascaded second-order nonlinearities in planar waveguides. PMID- 9964351 TI - Achievable spatial resolution of time-resolved transillumination imaging systems which utilize multiply scattered light. PMID- 9964352 TI - Multiple scattering of hard gamma quanta in a medium. PMID- 9964353 TI - Two-state bright solitons in doped fibers with saturating nonlinearity. PMID- 9964355 TI - Singularities and special soliton solutions of the cubic-quintic complex Ginzburg Landau equation. PMID- 9964354 TI - Discrete self-trapping, soliton interactions, and beam steering in nonlinear waveguide arrays. PMID- 9964356 TI - Discrete lattice effects on breathers in a spatially linear potential. PMID- 9964357 TI - Method for computing long periodic orbits of dynamical systems. PMID- 9964358 TI - Cluster dynamics for randomly frustrated systems with finite connectivity. PMID- 9964360 TI - Bifurcation and chaos induced by a time-periodic vector potential. PMID- 9964359 TI - Phase space approach for optimizing grid representations: The mapped Fourier method. PMID- 9964361 TI - Transient on-off intermittency in a coupled map lattice system. PMID- 9964363 TI - Numerical estimate of a scaling exponent characterizing fluctuating diffusion fronts. PMID- 9964362 TI - Classical stochasticity threshold and quantum mechanics. PMID- 9964364 TI - Nonlinear heat flux dependence of pressure in nonequilibrium gases. PMID- 9964365 TI - Decoherence of quantum-nondemolition systems. PMID- 9964367 TI - Resonance tunneling of a classical particle. PMID- 9964366 TI - Mechanism of generic time variability for chaotic pattern selection. PMID- 9964368 TI - Effects of reinjection on the scaling property of intermittency. PMID- 9964370 TI - Scale disparity and spectral transfer in anisotropic numerical turbulence. PMID- 9964369 TI - Topological dynamics in a catalysis experiment. PMID- 9964372 TI - Singular behavior of the velocity moments of a dilute gas under uniform shear flow. PMID- 9964371 TI - Subsurface deformations in nematic liquid crystals. PMID- 9964373 TI - Stochastic resonance in a neuron model that transmits spike trains. PMID- 9964374 TI - Learning rules for Potts neural networks with biased patterns. PMID- 9964375 TI - Colored noise in the dynamics of aqueous protein solutions. PMID- 9964376 TI - Nature of the alpha effect in magnetohydrodynamics. PMID- 9964378 TI - Comment on "Brownian motion of two interacting particles under a square-well potential" PMID- 9964377 TI - Effect of magnetized electron cooling on a Hopf bifurcation. PMID- 9964379 TI - Erratum: Supersaturated electrolyte solutions: Theory and experiment PMID- 9964381 TI - Chaotic systems with a null conditional Lyapunov exponent under nonlinear driving. PMID- 9964380 TI - Classical chaos and fluctuation-dissipation relations for nonlinear response. PMID- 9964382 TI - Mean-field solution of the random Ising model on the dual lattice. PMID- 9964383 TI - Quenched disorder, memory, and self-organization. PMID- 9964384 TI - Shock-wave structure for some nonanalytical in-velocity closures. PMID- 9964386 TI - Dynamics of monopole annihilation by type-1/2 strings in a nematic liquid crystal. PMID- 9964385 TI - Kolmogorov's refined similarity hypothesis for hyperviscous turbulence. PMID- 9964387 TI - Dynamical criterion for two-dimensional freezing. PMID- 9964388 TI - Structural dynamics of clusters near melting. PMID- 9964390 TI - Quantitative molecular interpretation of curvature elasticity of saturated surfactant monolayers. PMID- 9964389 TI - Topological interactions in model polymer networks. PMID- 9964391 TI - Supercooling of surface modified liquids. PMID- 9964392 TI - Using chaos control and tracking to suppress a pathological nonchaotic rhythm in a cardiac model. PMID- 9964393 TI - Dark and bright vector spatial solitons in biased photorefractive media. PMID- 9964394 TI - Chaos in special relativistic dynamics. PMID- 9964395 TI - Effect of symmetry breaking on "chaotic" eigenfunctions. PMID- 9964396 TI - Characterizing riddled fractal sets. PMID- 9964397 TI - Anisotropic distribution functions for relativistic galactic nuclei. PMID- 9964398 TI - Statistical fractals with cutoffs, Shlesinger-Hughes renormalization, and the onset of an epidemic. PMID- 9964399 TI - Correlations between eigenvalues of large random matrices with independent entries. PMID- 9964400 TI - Hamiltonian approach to kinetic Ising models. PMID- 9964401 TI - Eigenvalue spectrum of the Frobenius-Perron operator near intermittency. PMID- 9964402 TI - Molecular dynamics simulations of tethered membranes with periodic boundary conditions. PMID- 9964403 TI - Multiscaling to standard-scaling crossover in the Bray-Humayun model for phase ordering kinetics. PMID- 9964404 TI - Presence of chaos in a self-organized critical system. PMID- 9964405 TI - Symbolic dynamics analysis of chaotic time series with a driven frequency. PMID- 9964406 TI - Full stability-exponent placement in chaotic systems. PMID- 9964407 TI - Interfacial instability induced by external fluctuations. PMID- 9964408 TI - Universal power law in the noise from a crumpled elastic sheet. PMID- 9964409 TI - Diffusion with critically correlated traps and the slow relaxation of the longest wavelength mode. PMID- 9964410 TI - Nonequilibrium correlation functions in the A+A-->0 system with driven diffusion. PMID- 9964411 TI - Folding transitions of the triangular lattice with defects. PMID- 9964412 TI - Lyapunov instability in a system of hard disks in equilibrium and nonequilibrium steady states. PMID- 9964413 TI - Nonclassical kinetics in three dimensions: Simulations of elementary A+B and A+A reactions. PMID- 9964414 TI - Scaling laws for river networks. PMID- 9964415 TI - Simulation of correlated and uncorrelated packing of random size spheres. PMID- 9964417 TI - Broken ergodicity in the self-consistent dynamics of the two-dimensional random sine-Gordon model. PMID- 9964416 TI - Large time nonequilibrium dynamics of a particle in a random potential. PMID- 9964419 TI - Dissipative particle dynamics for a harmonic chain: A first-principles derivation. PMID- 9964418 TI - Reaction kinetics of cluster impurities. PMID- 9964420 TI - Multiple transitions to chaos in a damped parametrically forced pendulum. PMID- 9964421 TI - Mutual diffusion in binary Ar-Kr mixtures and empirical diffusion models. PMID- 9964422 TI - Steady state hydrodynamics of a lattice Boltzmann immiscible lattice gas. PMID- 9964423 TI - Probability density functions, skewness, and flatness in large Reynolds number turbulence. PMID- 9964424 TI - Fluctuating hydrodynamic interfaces: Theory and simulation. PMID- 9964426 TI - Surface tension of freestanding partially fluorinated liquid-crystal films. PMID- 9964425 TI - Analysis of a pattern-forming lattice-gas automaton: Mean-field theory and beyond. PMID- 9964428 TI - Fluctuations and light scattering in a liquid crystal polymer fiber. PMID- 9964427 TI - Phase equilibria in solutions of disklike particles. PMID- 9964429 TI - Solution of the Oldano-Barbero paradox. PMID- 9964430 TI - Influence of surface elasticity on the director profile of nontwisted nematic liquid-crystal cells. PMID- 9964431 TI - Ground-state phase diagram of the ordered columnar phases of liquid-crystal materials. PMID- 9964433 TI - Anomalous glass transitions and stretched exponential relaxation in fused salts and polar organic compounds. PMID- 9964432 TI - Variational approach for minimizing Lennard-Jones energies. PMID- 9964434 TI - Scroll breakup in a three-dimensional excitable medium. PMID- 9964435 TI - Evaluation of the counterion distribution around spherical micelles in solution by small-angle neutron scattering. PMID- 9964436 TI - Role of nucleation in the structure evolution of a magnetorheological fluid. PMID- 9964437 TI - Electrodeposition: The role of concentration in the phase diagram and the Hecker transition. PMID- 9964438 TI - Self-diffusion in dilute quasi-two-dimensional hard sphere suspensions: Evanescent wave light scattering and video microscopy studies. PMID- 9964439 TI - Interferometric characterization of growth dynamics during dendritic electrodeposition of zinc. PMID- 9964440 TI - Percolation in cluster-cluster aggregation processes. PMID- 9964441 TI - Number of branches in diffusion-limited aggregates: The skeleton. PMID- 9964442 TI - Cell dynamics model of droplet formation in polymer-dispersed liquid crystals. PMID- 9964443 TI - Individual entanglements in a simulated polymer melt. PMID- 9964444 TI - Probe diffusion in gels. PMID- 9964445 TI - Wavelet analysis of DNA sequences. PMID- 9964447 TI - Enhanced Raman forward scattering. PMID- 9964446 TI - Response of bacterial colonies to imposed anisotropy. PMID- 9964449 TI - Backward- and traveling-wave tubes with dielectric-lined rippled-wall waveguides. PMID- 9964448 TI - Cathode-fall development in low-pressure, parallel-plane hydrogen discharges. PMID- 9964451 TI - Nonconservative Lagrangian and Hamiltonian mechanics. PMID- 9964450 TI - Temporal dynamics of storage ring free electron lasers. PMID- 9964452 TI - Tri-Hamiltonian duality between solitons and solitary-wave solutions having compact support. PMID- 9964453 TI - Schwinger variational principle calculations of wave scattering from conducting cylinders using physically motivated trial functions. PMID- 9964454 TI - Elastodynamics of self-gravitating matter: Nonradial vibrations of a star modeled by a heavy spherical mass of an elastic solid. PMID- 9964456 TI - Three forms of localized solutions of the quintic complex Ginzburg-Landau equation. PMID- 9964455 TI - Discontinuous decompaction of a falling sandpile. PMID- 9964457 TI - Nonlinear theory of oscillating, decaying, and collapsing solitons in the generalized nonlinear Schrodinger equation. PMID- 9964459 TI - Wavelet transform analysis directly from sinusoid crossings. PMID- 9964458 TI - Strongly convergent method to solve one-dimensional quantum problems. PMID- 9964460 TI - Numerical solution of the Schrodinger equation using discrete kinetic theory. PMID- 9964461 TI - Fast Fourier transform computational method for the propagation of electromagnetic pulses through layered dielectric media. PMID- 9964463 TI - Kinetic self-avoiding walks on randomly diluted lattices at the percolation threshold. PMID- 9964462 TI - Cooling-rate dependence of the ground-state energy using microcanonical simulated annealing. PMID- 9964464 TI - Free-volume fraction in hard-sphere mixtures and the osmotic spinodal curve. PMID- 9964465 TI - Evaporatively controlled growth of salt trees. PMID- 9964466 TI - Reply to "Comment on 'Small-scale intermittency in randomly stirred fluids' " PMID- 9964467 TI - Short-range screening potentials for classical Coulomb fluids: Reanalysis of Monte Carlo sampling and cluster model studies. PMID- 9964468 TI - Reply to "Short-range screening potentials for classical Coulomb fluids: Reanalysis of Monte Carlo sampling and cluster model studies" PMID- 9964470 TI - Experimental features and characteristics of traffic jams. PMID- 9964471 TI - Spatiotemporal on-off intermittency by random driving. PMID- 9964469 TI - Erratum: Dynamics in viscous orthoterphenyl: Results from coherent neutron scattering PMID- 9964473 TI - Exact transition operators for Markov and lattice Schrodinger processes constrained by a boundary. PMID- 9964472 TI - Chaotic spatially subharmonic oscillations. PMID- 9964474 TI - Infrared singularities in interface growth models. PMID- 9964475 TI - Universality in sandpile models. PMID- 9964476 TI - Hopf bifurcation by frustrated drifts. PMID- 9964477 TI - Nonlinearities in conservative growth equations. PMID- 9964478 TI - Evidence of two structural relaxation processes near the glass transition of a strong glass former. PMID- 9964479 TI - Measurements of extreme uv opacities in hot dense Al, Fe, and Ho. PMID- 9964480 TI - Stabilization of soliton instabilities by higher-order dispersion: Fourth-order nonlinear Schrodinger-type equations. PMID- 9964481 TI - Defocusing regimes of nonlinear waves in media with negative dispersion. PMID- 9964482 TI - Nonperturbative calculation of the probability distribution of plane-wave transmission through a disordered waveguide. PMID- 9964483 TI - Nonpolynomial fitting of multiparameter functions. PMID- 9964484 TI - Thermodynamic renormalization group. PMID- 9964485 TI - Scaling laws for spatiotemporal synchronization and array enhanced stochastic resonance. PMID- 9964486 TI - Concept of complexity in random dynamical systems. PMID- 9964487 TI - Layer features of the lattice gas model for self-organized criticality. PMID- 9964488 TI - Finite-size scaling Casimir force function: Exact spherical-model results. PMID- 9964489 TI - General analysis of instabilities in erbium-doped fiber lasers. PMID- 9964490 TI - Time-reversible dissipative ergodic maps. PMID- 9964492 TI - Stationary nonequilibrium ensembles for thermostated systems. PMID- 9964491 TI - Adsorption in models of ideal polymer chains on fractal spaces. PMID- 9964493 TI - Billiard boundary perturbations and periodic orbits. PMID- 9964494 TI - Estimation of asymmetry in physics. PMID- 9964495 TI - Detecting differences between delay vector distributions. PMID- 9964496 TI - Universal formulas for percolation thresholds. PMID- 9964497 TI - Nonequilibrium phase transition and self-organized criticality in a sandpile model with stochastic dynamics. PMID- 9964498 TI - Dynamics of an underdamped Josephson-junction ladder. PMID- 9964499 TI - Generalized mean-field study of a driven lattice gas. PMID- 9964500 TI - Unitary random-matrix ensemble with governable level confinement. PMID- 9964501 TI - Relaxation processes in one-dimensional self-gravitating many-body systems. PMID- 9964502 TI - Decay of classical chaotic systems: The case of the Bunimovich stadium. PMID- 9964504 TI - Directed-percolation conjecture for cellular automata. PMID- 9964503 TI - Nonuniversal critical spreading in two dimensions. PMID- 9964505 TI - Nonequilibrium fluctuation-induced phenomena in Josephson junctions. PMID- 9964506 TI - Exact solution to the exit-time problem for an undamped free particle driven by Gaussian white noise. PMID- 9964507 TI - Ticking hour glasses: Experimental analysis of intermittent flow. PMID- 9964508 TI - Diffusion in the presence of partial absorbers. PMID- 9964509 TI - Feedback control of chaotic motions and unstable wave packets in a space-time dependent system. PMID- 9964510 TI - Levy diffusion and classes of universal parametric correlations. PMID- 9964511 TI - Fractal dimension fluctuations for snapshot attractors of random maps. PMID- 9964512 TI - Current distribution in the three-dimensional random resistor network at the percolation threshold. PMID- 9964513 TI - Calculation of the effective diffusivity of heterogeneous media using the lattice Boltzmann method. PMID- 9964514 TI - Fractal dimensions of sediments in nature. PMID- 9964515 TI - Gigahertz photon density waves in a turbid medium: Theory and experiments. PMID- 9964516 TI - Invariance properties and correlation functions in liquid-state theory: Connection with the Ward-Takahashi identities. PMID- 9964517 TI - Thermodynamics of fluids obtained by mapping the collision properties. PMID- 9964518 TI - Predictability in systems with many characteristic times: The case of turbulence. PMID- 9964519 TI - Effective field theory for hard-sphere fluids. PMID- 9964520 TI - Conditionally averaged vorticity field and turbulence modeling. PMID- 9964521 TI - Probability distribution of hard-disk and hard-sphere gases over finite subvolumes. PMID- 9964522 TI - Gas-kinetic derivation of Navier-Stokes-like traffic equations. PMID- 9964523 TI - Finite-size effects in molecular dynamics simulations: Static structure factor and compressibility. I. Theoretical method. PMID- 9964524 TI - Finite-size effects in molecular dynamics simulations: Static structure factor and compressibility. II. Application to a model krypton fluid. PMID- 9964525 TI - Nematic ordering in highly restrictive Vycor glass. PMID- 9964526 TI - Electro-optic properties of a polymer-dispersed liquid-crystal film: Temperature dependence and phase behavior. PMID- 9964527 TI - Morphological instabilities of a nonequilibrium nematic-isotropic interface. PMID- 9964529 TI - Mean-field nematic-smectic-A transition in a random polymer network. PMID- 9964528 TI - Anchoring of nematic liquid crystals at a solid substrate. PMID- 9964530 TI - Determination of the effective splay-bend elastic constant of a lyotropic nematic liquid crystal. PMID- 9964531 TI - Substrate-induced bulk alignment of liquid crystals. PMID- 9964532 TI - Metastability of freely suspended liquid-crystal films. PMID- 9964534 TI - Structures of hard-core Yukawa clusters and the tail-range dependence of the existence of a liquidlike cluster phase: Relevance to the physics of C60. PMID- 9964533 TI - Coverage fluctuation and the available line fraction for spheres deposited on a one-dimensional collector after diffusion under the influence of gravity. PMID- 9964535 TI - Optical hysteresis in laser-induced liquid-liquid phase separation. PMID- 9964536 TI - Fractal nature of viscous fingering in three-dimensional pore-level models. PMID- 9964537 TI - Structural and thermal properties of orientationally ordered dipolar fluids. PMID- 9964538 TI - Wormlike micelles under shear flow: A microscopic model studied by nonequilibrium molecular-dynamics computer simulations. PMID- 9964539 TI - Growth dynamics and morphology of passive films. PMID- 9964540 TI - Energy dissipation of fluid membranes. PMID- 9964541 TI - Free energies of isolated five- and sevenfold disclinations in hexatic membranes. PMID- 9964542 TI - Dislocation-mediated melting near isostructural critical points. PMID- 9964543 TI - Circle, sphere, and drop packings. PMID- 9964544 TI - Pattern formations in lipid monolayers under illumination. PMID- 9964545 TI - Nonequilibrium structural changes of a viscoelastic liquid under oscillatory shear: A molecular dynamics study. PMID- 9964546 TI - Modulated structures in Langmuir monolayers and in smectic films. PMID- 9964547 TI - Time scales for transitions between free-energy minima of a dense hard-sphere system. PMID- 9964548 TI - Spinodal decomposition in binary mixtures. PMID- 9964549 TI - Light-scattering spectrum of supercooled liquids. PMID- 9964550 TI - Reaction-diffusion model for the hydration and setting of cement. PMID- 9964552 TI - Topological defects on fluctuating surfaces: General properties and the Kosterlitz-Thouless transition. PMID- 9964551 TI - Structures and phase transitions of amorphous ices. PMID- 9964553 TI - Sine-Gordon field theory for the Kosterlitz-Thouless transitions on fluctuating membranes. PMID- 9964554 TI - Shape transformations of vesicles with intramembrane domains. PMID- 9964555 TI - Relevance of surrogate-data testing in electroencephalogram analysis. PMID- 9964556 TI - Gaussian random field description of fluctuating fluid vesicles. PMID- 9964558 TI - Implicit-moment, partially linearized particle simulation of kinetic plasma phenomena. PMID- 9964557 TI - Measurement of the Coulomb energy loss by fast protons in a plasma target. PMID- 9964559 TI - Nonlinearities and instabilities of dissipative drift waves in dusty plasmas. PMID- 9964560 TI - Experimental demonstration of a high-power slow-wave electron cyclotron maser based on a combined resonance of Cherenkov and anomalous Doppler interactions. PMID- 9964561 TI - Negative differential conductivity of electrons in pure rare gases. PMID- 9964562 TI - Laser-Bernstein-mode coupling in a laser-produced plasma. PMID- 9964563 TI - Decay instability of an electron plasma wave in a dusty plasma. PMID- 9964565 TI - Atomic level population for nonideal plasmas in strong electric fields. PMID- 9964564 TI - Dependence of stimulated Brillouin scattering on laser intensity, laser f number, and ion species in hohlraum plasmas. PMID- 9964566 TI - Experimental investigation of the melting transition of the plasma crystal. PMID- 9964567 TI - Negative-energy perturbations in circularly cylindrical equilibria within the framework of Maxwell-drift kinetic theory. PMID- 9964568 TI - Formation of multiple subpulses in a free-electron laser operating in the limit cycle mode. PMID- 9964569 TI - Strong coupling operation of a free-electron-laser amplifier with an axial magnetic field. PMID- 9964570 TI - Excitation of cyclotron resonances from random fluctuations of stellarator windings. PMID- 9964571 TI - Resistive wall impedance as derivative of the electric capacitance for a beam pipe of arbitrary cross section. PMID- 9964572 TI - Space-charge-dominated bunched beams in the frequency domain. PMID- 9964573 TI - Particle size segregation in a two-dimensional bed undergoing vertical vibration. PMID- 9964575 TI - Mechanical equilibrium of conformal crystals. PMID- 9964574 TI - Unexpected behavior of nonlinear Schrodinger solitons in an external potential. PMID- 9964576 TI - Small-amplitude envelope solitons in nonlinear lattices. PMID- 9964577 TI - Resonances of a coated sphere. PMID- 9964578 TI - Linear stability analysis for propagating fracture. PMID- 9964579 TI - Theory for multiple light scattering from Rayleigh scatterers in magnetic fields. PMID- 9964580 TI - Systematic behavior of the Mie scattering coefficients of spheres as a function of order. PMID- 9964582 TI - Finite-size scaling and critical exponents in critical relaxation. PMID- 9964581 TI - Effective characteristic polynomials and two-point Pade approximants as summation techniques for the strongly divergent perturbation expansions of the ground state energies of anharmonic oscillators. PMID- 9964583 TI - Synchronization of chaotic systems by continuous control. PMID- 9964584 TI - Dynamical properties and predictability of a class of self-organized critical models. PMID- 9964585 TI - Simple model for Maxwell's-demon-type information engine. PMID- 9964586 TI - Generalized Lyapunov exponents for products of correlated random matrices. PMID- 9964587 TI - Solution of the Fokker-Planck equation for reactive Rayleigh gas. PMID- 9964588 TI - Thermodynamic self-consistency criterion in the mixed integral equation theory of liquid structure. PMID- 9964589 TI - Pattern formation in a vibrated two-dimensional granular layer. PMID- 9964590 TI - Surface-anisotropy-induced linear electro-optic effect in a nematic liquid crystal. PMID- 9964592 TI - Theoretical analysis of the helix-coil transition in positively superhelical DNA at high temperatures. PMID- 9964591 TI - Dynamic light scattering from power-law polydisperse fractals: Application of dynamic scaling to humic acid. PMID- 9964593 TI - Head-on collision of two concentric cylindrical ion acoustic solitary waves. PMID- 9964594 TI - Comment on "Translation-rotation paradox for diffusion in fragile glass-forming liquids" PMID- 9964595 TI - Reply to "Comment on 'Translation-rotation paradox for diffusion in fragile glass forming liquids' " PMID- 9964596 TI - Reaction-diffusion front for A+B--> PMID- 9964597 TI - Signal detection statistics of stochastic resonators. PMID- 9964599 TI - Optimal path and directed percolation. PMID- 9964598 TI - Symbolic dynamics for strong chaos on stochastic webs: General quasisymmetry. PMID- 9964600 TI - Exact master equations for driven dissipative tight-binding models. PMID- 9964601 TI - Hexagonal convection cells under conditions of vertical symmetry. PMID- 9964602 TI - Different convection dynamics in mixtures with the same separation ratio. PMID- 9964603 TI - Plasma influence on the dispersion properties of finite-length, corrugated waveguides. PMID- 9964604 TI - Structural analysis of a Coulomb lattice in a dusty plasma. PMID- 9964605 TI - Effect of strongly favorable substrate interactions on the thermal properties of ultrathin polymer films. PMID- 9964606 TI - Instability threshold in the Benard-Marangoni problem. PMID- 9964607 TI - Learning from minimum entropy queries in a large committee machine. PMID- 9964609 TI - Electron cavitation and acceleration in the wake of an ultraintense, self-focused laser pulse. PMID- 9964608 TI - Multifractal analysis of the coupling space of feedforward neural networks. PMID- 9964611 TI - Synchronization in small assemblies of chaotic systems. PMID- 9964610 TI - Subpicosecond compression of 0.1-1 nC electron bunches with a magnetic chicane at 8 MeV. PMID- 9964612 TI - Phase diffusion in a chaotic pendulum. PMID- 9964613 TI - Bounds on the decay of the autocorrelation in phase ordering dynamics. PMID- 9964614 TI - Coarsening and persistence in the voter model. PMID- 9964615 TI - Stochastic chaos and resonance in a bistable stochastic system. PMID- 9964616 TI - Quantum tunneling, dynamical symmetry, and quantum revival. PMID- 9964618 TI - Amplitude-independent chaotic synchronization. PMID- 9964617 TI - General theory of instabilities for patterns with sharp interfaces in reaction diffusion systems. PMID- 9964619 TI - Semiquantum chaos in the double well. PMID- 9964621 TI - Memory and correlation effects in the quantum theory of thermalization. PMID- 9964620 TI - Kinetics of multidimensional fragmentation. PMID- 9964623 TI - Mean field equation for the curvature-driven motion of bicontinuous, random interfaces. PMID- 9964622 TI - Annihilation of charged particles. PMID- 9964624 TI - Spatial correlations and cross sections of clusters in the A+B-->0 reaction. PMID- 9964625 TI - Theory and system analysis of field-dependent thermodynamic variables and Maxwell relations. PMID- 9964626 TI - Synchronization of nonlinear systems with distinct parameters: Phase synchronization and metamorphosis. PMID- 9964627 TI - Energy spectra of the hydrogen atom and the harmonic oscillator in two dimensions from Bogomolny's semiclassical transfer operator. PMID- 9964628 TI - Determining exponents in models of kinetic surface roughening. PMID- 9964630 TI - Finite-size scaling and the toroidal partition function of the critical asymmetric six-vertex model. PMID- 9964629 TI - Angular distribution of diffusely transmitted light. PMID- 9964631 TI - First-passage-time statistics for diffusion processes with an external random force. PMID- 9964632 TI - Ergodicity in hard-ball systems and Boltzmann's entropy. PMID- 9964633 TI - Folding transition of the triangular lattice in a discrete three-dimensional space. PMID- 9964634 TI - Information-theoretic characterization of quantum chaos. PMID- 9964635 TI - Band structure and quantum Poincare sections of a classically chaotic quantum rippled channel. PMID- 9964637 TI - Multi-interaction mean-field renormalization group. PMID- 9964636 TI - Ray splitting and quantum chaos. PMID- 9964638 TI - Nonequilibrium phase transition in the case of correlated noises. PMID- 9964639 TI - Universal behavior of the amplitude ratio of percolation susceptibilities for off lattice percolation models. PMID- 9964640 TI - Intermittent chaos and multifractal systems. PMID- 9964642 TI - Apparent fractality emerging from models of random distributions. PMID- 9964641 TI - Universal short-time dynamics in the Kosterlitz-Thouless phase. PMID- 9964643 TI - Dissipative effects on the localization of a charged oscillator in a magnetic field. PMID- 9964644 TI - Reconstruction of a first-order phase transition from computer simulations of individual phases and subphases. PMID- 9964645 TI - Chaos in a quantum well in tilted fields: A scaling system. PMID- 9964647 TI - Chaos for Liouville probability densities. PMID- 9964646 TI - Lyapunov spectral analysis of a nonequilibrium Ising-like transition. PMID- 9964649 TI - Self-organized criticality in a hierarchical model of defects development. PMID- 9964648 TI - Microcanonical ensemble Monte Carlo method for discrete systems. PMID- 9964650 TI - Nucleation model for diffusion-limited coalescence with finite reaction rates in one dimension. PMID- 9964652 TI - Noise-induced phase transitions in globally coupled active rotators. PMID- 9964651 TI - Maximal Lyapunov exponent at crises. PMID- 9964653 TI - Isotropic and anisotropic spectra of passive scalar fluctuations in turbulent fluid flow. PMID- 9964655 TI - Capillary gravity waves caused by a moving disturbance: Wave resistance. PMID- 9964654 TI - Scaling laws at nonlinear Schrodinger defect sites. PMID- 9964656 TI - Structure factor of hard spheres near a wall. PMID- 9964657 TI - Exact resummations in the theory of hydrodynamic turbulence. III. Scenarios for anomalous scaling and intermittency. PMID- 9964659 TI - Transition to weak turbulence via spatiotemporal intermittency in the Taylor-Dean system. PMID- 9964658 TI - Domain stability, competition, growth, and selection in globally constrained bistable systems. PMID- 9964660 TI - High-pressure neutron diffraction on fluid methane. PMID- 9964661 TI - Anomalous scaling in a model of passive scalar advection: Exact results. PMID- 9964662 TI - Stochastic process for the dynamics of the turbulent cascade. PMID- 9964664 TI - Connection between the Rayleigh and the Schrodinger equations. PMID- 9964663 TI - Helical shell models for three-dimensional turbulence. PMID- 9964665 TI - Bifurcations on the fcc lattice. PMID- 9964666 TI - Quasi-self-similarity for wetting drops. PMID- 9964667 TI - Nonlinear electrohydrodynamic waves on films falling down an inclined plane. PMID- 9964668 TI - Oscillatory bifurcation with broken translation symmetry. PMID- 9964669 TI - Oscillatory doubly diffusive convection in a finite container. PMID- 9964671 TI - Phase equilibria of a polymer-smectic-liquid-crystal mixture. PMID- 9964670 TI - Twisting transition in a fiber composed of chiral smectic-C liquid crystal polymer. PMID- 9964672 TI - Fluctuations and light scattering in free-standing smectic-C films. PMID- 9964673 TI - Nematic ordering in porous glasses: A deuterium NMR study. PMID- 9964675 TI - Systematic study of orientational wetting and anchoring at a liquid-crystal surfactant interface. PMID- 9964674 TI - Nature of the smectic-A-hexatic-B-crystal-B transitions of a liquid-crystal compound. PMID- 9964676 TI - Phase diagram of branched polymer collapse. PMID- 9964677 TI - Spinodal decomposition in multicomponent fluid mixtures: A molecular dynamics study. PMID- 9964678 TI - Generic rigidity percolation in two dimensions. PMID- 9964679 TI - Lyapunov instability of fluids composed of rigid diatomic molecules. PMID- 9964680 TI - Fractal model of consolidation of weakly aggregated colloidal dispersions. PMID- 9964681 TI - Molecular dynamics simulations of phase separation in chemically reactive binary mixtures. PMID- 9964682 TI - Dynamics and conformation of polymer chains in a porous medium. PMID- 9964683 TI - Shear flow of one-component polarizable fluid in a strong electric field. PMID- 9964684 TI - Surface tension, hydrophobicity, and black holes: The entropic connection. PMID- 9964685 TI - Static properties of confined colloidal suspensions. PMID- 9964686 TI - Boundary layer analysis of the ridge singularity in a thin plate. PMID- 9964687 TI - Computation of the dendritic operating state at large supercoolings by the phase field model. PMID- 9964688 TI - Anisotropic surface morphology of poly(vinyl 4-methoxy-cinnamate) and 12 8(poly)diacetylene thin films induced by linear photopolymerization. PMID- 9964689 TI - Deformation of grafted polymer layers in strong shear flows. PMID- 9964690 TI - Experiments on anisotropic radial viscous fingering. PMID- 9964691 TI - Observation of a two-stage melting transition in two dimensions. PMID- 9964692 TI - Theory of cylindrical tubules and helical ribbons of chiral lipid membranes. PMID- 9964693 TI - Unwinding a polymer in a poor solvent. PMID- 9964694 TI - Computer simulation of structures and rheological properties of electrorheological fluids. PMID- 9964696 TI - Gradient diffusion in concentrated ferrocolloids under the influence of a magnetic field. PMID- 9964695 TI - Mixing of a two-phase fluid by cavity flow. PMID- 9964698 TI - Critical behavior in a polymer blend. PMID- 9964697 TI - Density functional approach to the structure of homogeneous colloidal dispersion. PMID- 9964699 TI - Conductivity of random sphere packings: Effects of a size distribution. PMID- 9964701 TI - Pore formation and rupture in fluid bilayers. PMID- 9964700 TI - Weak pinning of interfaces. PMID- 9964702 TI - Gaussian self-consistent method for the kinetics of heteropolymers: A direction in studying the protein folding problem. PMID- 9964703 TI - Experimental investigation of the structure of nonionic microemulsions and their relation to the bending elasticity of the amphiphilic film. PMID- 9964704 TI - Two-scale model for aggregation and etching. PMID- 9964705 TI - Coarsening kinetics in finite clusters. PMID- 9964706 TI - Interface proliferation and the growth of labyrinths in a reaction-diffusion system. PMID- 9964708 TI - Perturbative treatments and learning techniques. PMID- 9964707 TI - Cooperative behavior in periodically driven noisy integrate-fire models of neuronal dynamics. PMID- 9964710 TI - Classification of time series with hidden Markov models: Unsupervised learning and self-organization. PMID- 9964709 TI - Probabilistic cellular automaton describing a biological immune system. PMID- 9964711 TI - Learning by examples from a nonuniform distribution. PMID- 9964712 TI - Normal approach to the linearized Fokker-Planck equation for the inverse-square force. PMID- 9964713 TI - Excitation of 2p levels of argon in Townsend discharges at a high ratio of electric field to gas density. PMID- 9964715 TI - Self-consistent analytical model of the Rayleigh-Taylor instability in inertial confinement fusion. PMID- 9964714 TI - Momentum transfer theory of nonconservative charged particle transport in mixtures of gases: General equations and negative differential conductivity. PMID- 9964716 TI - Langmuir oscillations in a cold inhomogeneous plasma. PMID- 9964717 TI - Kinetic Alfven wave in three-component dusty plasmas. PMID- 9964718 TI - Transition to turbulence via spatiotemporal intermittency in stimulated Raman backscattering. PMID- 9964720 TI - Uniaxial nonlinear surface waves. PMID- 9964721 TI - Symmetric and asymmetric solitons in twin-core nonlinear optical fibers. PMID- 9964719 TI - Dynamic-aperture estimates and phase-space distortions in nonlinear betatron motion. PMID- 9964722 TI - Two-dimensional spatial optical solitons in bulk Kerr media stabilized by self induced multiphoton ionization: Variational approach. PMID- 9964723 TI - Transfer matrices for multiport devices made from solitons. PMID- 9964725 TI - Localization of light in three-dimensional random dielectric media. PMID- 9964724 TI - Analytic expressions for the electromagnetic mode density in finite, one dimensional, photonic band-gap structures. PMID- 9964726 TI - Perturbation theories of a discrete, integrable nonlinear Schrodinger equation. PMID- 9964727 TI - Zero-crosstalk junctions made from dark solitons. PMID- 9964728 TI - Generation of high-energy localized vibrational modes in nonlinear Klein-Gordon lattices. PMID- 9964730 TI - Eigenvalue density oscillations in separable microwave resonators. PMID- 9964729 TI - Constitutive relation for the friction between lubricated surfaces. PMID- 9964731 TI - Torsion dynamics of molecular systems. PMID- 9964732 TI - Thermal excitation of the H atom. PMID- 9964734 TI - Zipf's law in percolation. PMID- 9964733 TI - Alternative model of dissipation in quantum mechanics. PMID- 9964735 TI - Stochastic foundations of fractional dynamics. PMID- 9964736 TI - Generalized flow equation and kinetic coefficients in a reaction-diffusion system. PMID- 9964738 TI - Surface defects and forces in nematic liquid crystal samples. PMID- 9964737 TI - Flow alignment in the helix uncoiling of sheared cholesteric liquid crystals. PMID- 9964739 TI - Periodic cylindrical surface solution for fluid bilayer membranes. PMID- 9964741 TI - Universal topological properties of shells in soap froth. PMID- 9964740 TI - Agglomerate erosion: A nonscaling solution to the fragmentation equation. PMID- 9964743 TI - Protein dynamics with off-lattice Monte Carlo moves. PMID- 9964742 TI - Effect of time correlation of input patterns on the convergence of on-line learning. PMID- 9964744 TI - Localized structures of electromagnetic waves in hot electron-positron plasmas. PMID- 9964746 TI - Fast Monte Carlo algorithm for nonequilibrium systems. PMID- 9964745 TI - Resonance shift in relativistic traveling wave amplifiers. PMID- 9964747 TI - Energy derivatives in variational calculations using Slater-type and Gauss-type orbitals. PMID- 9964748 TI - Comment on "Nonlinear resonance and chaos in the relativistic phase space for driven nonlinear systems" PMID- 9964749 TI - Reply to "Comment on 'Nonlinear resonance and chaos in the relativistic phase space for driven nonlinear systems' " PMID- 9964750 TI - Comment on "Exact solution of the wave dynamics of a particle bouncing chaotically on a periodically oscillating wall" PMID- 9964751 TI - Erratum: Vortex filament dynamics in plasmas and superconductors PMID- 9964752 TI - Array-enhanced friction in the periodic stick-slip motion of nonlinear oscillators. PMID- 9964753 TI - Exact results for kinetics of catalytic reactions. PMID- 9964754 TI - Oscillatory kinetics of reactions on solid surfaces resulting from bistability and diffusion limitations. PMID- 9964756 TI - Anomalous scaling for passively advected magnetic fields. PMID- 9964755 TI - Phase-field method for computationally efficient modeling of solidification with arbitrary interface kinetics. PMID- 9964758 TI - Transition in particle capture in deep bed filtration. PMID- 9964757 TI - Scaling property of turbulent flows. PMID- 9964759 TI - Statistical two-vortex equilibrium and vortex merger. PMID- 9964761 TI - Molecular dynamics simulation evidence of anomalous diffusion of protein hydration water. PMID- 9964760 TI - Gaussian tricritical behavior of heat capacity at the smectic-A-smectic-C liquid crystal transition. PMID- 9964762 TI - Amplitude, wave form, and temperature dependence of bilayer ripples in the P beta ' phase. PMID- 9964763 TI - Wave-field distributions for toroidal plasmas with nearly circular cross sections. PMID- 9964764 TI - Detection of THz pulses by phase retardation in lithium tantalate. PMID- 9964765 TI - Generalized simulated annealing algorithms using Tsallis statistics: Application to conformational optimization of a tetrapeptide. PMID- 9964766 TI - Controlling chaos in high dimensions: Theory and experiment. PMID- 9964767 TI - Density waves in dry granular media falling through a vertical pipe. PMID- 9964768 TI - Encoding messages using chaotic synchronization. PMID- 9964769 TI - Three kinds of intermittency in a nonlinear mechanical system. PMID- 9964770 TI - Microstructure and conductivity of hierarchical laminate composites. PMID- 9964771 TI - Hydrodynamic modes as singular eigenstates of the Liouvillian dynamics: Deterministic diffusion. PMID- 9964772 TI - Duffing equation with two periodic forcings: The phase effect. PMID- 9964773 TI - Casimir effect in critical systems: A Monte Carlo simulation. PMID- 9964774 TI - Mode-coupling and renormalization group results for the noisy Burgers equation. PMID- 9964775 TI - Spatiotemporal periodic pattern and propagated spatiotemporal on-off intermittency in the one-way coupled map lattice system. PMID- 9964776 TI - Quantum-classical comparison in chaotic systems. PMID- 9964778 TI - Synchronization in coupled sine circle maps. PMID- 9964777 TI - Mechanisms of ergodic torus destruction and appearance of strange nonchaotic attractors. PMID- 9964779 TI - Many-body diffusion and path integrals for identical particles. PMID- 9964780 TI - Computational complexity of symbolic dynamics at the onset of chaos. PMID- 9964781 TI - Navier-Stokes equations for stochastic lattice gases. PMID- 9964782 TI - Effects of random motions on critical point measurements: Liquid-gas systems in microgravity. PMID- 9964783 TI - Associative memory with spatiotemporal chaos control. PMID- 9964784 TI - Transient 1/f noise. PMID- 9964785 TI - Chaos and detection. PMID- 9964786 TI - Chaotic evolution in quantum mechanics. PMID- 9964787 TI - Generalized synchronization of chaos: The auxiliary system approach. PMID- 9964788 TI - Variational formulation of sandpile dynamics. PMID- 9964789 TI - Renormalized field theory and particle density profile in driven diffusive systems with open boundaries. PMID- 9964790 TI - Eigenvalues and eigenfunctions of billiards in a constant magnetic field. PMID- 9964791 TI - Correlations in quantum plasmas. I. Resummations in Mayer-like diagrammatics. PMID- 9964792 TI - Correlations in quantum plasmas. II. Algebraic tails. PMID- 9964793 TI - On-shell expansion of the nonequilibrium generating functional: Application to superfluid 4He. PMID- 9964794 TI - Particle hopping models and traffic flow theory. PMID- 9964795 TI - Model for force fluctuations in bead packs. PMID- 9964796 TI - Structure factor tail for the ordering kinetics of nonconserved systems without topological defects. PMID- 9964797 TI - Critical dynamics of a dynamical version of the classical Heisenberg model. PMID- 9964798 TI - Fluctuation-dissipation relations and universal behavior for relaxation processes in systems with static disorder and in the theory of mortality. PMID- 9964799 TI - Decoherence and classical predictability of phase-space histories. PMID- 9964800 TI - 1/f noise in the Bak-Sneppen model. PMID- 9964801 TI - Fractal properties of the stretch-twist-fold magnetic dynamo. PMID- 9964802 TI - Polymers with restricted branching. PMID- 9964803 TI - Thermodynamic description of the relaxation of two-dimensional turbulence using Tsallis statistics. PMID- 9964804 TI - Pattern selection in the absolutely unstable regime as a nonlinear eigenvalue problem: Taylor vortices in axial flow. PMID- 9964805 TI - Acoustic effects in the nonlinear oscillations of planar detonations. PMID- 9964806 TI - Cascades and statistical equilibrium in shell models of turbulence. PMID- 9964807 TI - Morphological characterization of patterns in reaction-diffusion systems. PMID- 9964808 TI - Measurements of ferrofluid surface tension in confined geometry. PMID- 9964809 TI - Undulating rolls and their instabilities in a Rayleigh-Benard layer. PMID- 9964810 TI - Structure of hard-sphere metastable fluids. PMID- 9964811 TI - Landau-Darrieus instability and the fractal dimension of flame fronts. PMID- 9964812 TI - Two-layer model showing a variety of pattern types near nonequilibrium phase transitions. PMID- 9964813 TI - High-Rayleigh-number convection in spherical shells. PMID- 9964814 TI - Stokes drag and lubrication flows: A molecular dynamics study. PMID- 9964815 TI - Non-Gaussian statistics, classical field theory, and realizable Langevin models. PMID- 9964816 TI - Dynamics of Turing pattern monolayers close to onset. PMID- 9964818 TI - Kinetics of phase ordering of nematic liquid crystals in a confined geometry. PMID- 9964817 TI - Thermal signature of plumes in turbulent convection: The skewness of the derivative. PMID- 9964819 TI - Orientational order and micelle size in the nematic phase of the cesium pentadecafluorooctanoate-water system from the anisotropic self-diffusion of water. PMID- 9964820 TI - Quasistatic domains in planar nematic liquid crystals around the dielectric inversion point. PMID- 9964821 TI - Flow-alignment instability and slow director oscillations in nematic liquid crystals under oscillatory flow. PMID- 9964822 TI - Theory of modulated phases in lipid bilayers and liquid crystal films. PMID- 9964823 TI - Percus-Yevick approximation for fluids with spontaneous partial order: Results for a separable model. PMID- 9964824 TI - Critical point for the blue-phase-III-isotropic phase transition in chiral liquid crystals. PMID- 9964825 TI - Morphological stability of islands upon thin-film condensation. PMID- 9964826 TI - Entropic trapping and electrophoretic drift of a polyelectrolyte down a channel with a periodically oscillating width. PMID- 9964827 TI - Effect of the particle surface charge density on the colloidal aggregation mechanism. PMID- 9964828 TI - Electrochemical deposition with a forced fluid flow inducing a transition from dendrites to disordered ramified morphologies. PMID- 9964829 TI - Generation of transverse fluid currents and forces by an electric field: Electro osmosis on charge-modulated and undulated surfaces. PMID- 9964831 TI - Dynamical correlations in suspensions of charged rodlike macromolecules. PMID- 9964830 TI - Pinning of a solid-liquid-vapor interface by stripes of obstacles. PMID- 9964832 TI - Interface localization transition in Ising films with competing walls: Ginzburg criterion and crossover scaling. PMID- 9964833 TI - Discontinuous interface depinning from a rough wall. PMID- 9964834 TI - Phase-field model for dendritic growth in a channel. PMID- 9964836 TI - Generalized needle solutions, interfacial instabilities, and pattern formation. PMID- 9964835 TI - Brownian dynamics simulation of gelation and aging in interacting colloidal systems. PMID- 9964837 TI - Topological effects in ring polymers: A computer simulation study. PMID- 9964838 TI - Shear effects during the gelation of aqueous gelatin. PMID- 9964839 TI - Coherent neutron scattering response from glassy glycerol. PMID- 9964840 TI - Dynamics of a freely evolving, two-dimensional granular medium. PMID- 9964841 TI - Spinodal decomposition in an order-disorder transition: Effect of interfacial properties. PMID- 9964843 TI - Dynamics of the spreading of chainlike molecules with asymmetric surface interactions. PMID- 9964842 TI - Frozen and active regions in diffusion-limited aggregation clusters. PMID- 9964844 TI - Growth in systems of vesicles and membranes. PMID- 9964846 TI - Physical model of voltage sensing in sodium channels based on the sliding helix complex. PMID- 9964845 TI - Stress tensor of liquid-vapor states of inhomogeneous fluids. PMID- 9964847 TI - Effects of refractory periods in the dynamics of a diluted neural network. PMID- 9964848 TI - Bifurcations in mean-field-theory annealing. PMID- 9964849 TI - Small-angle neutron scattering from multilamellar lipid bilayers: Theory, model, and experiment. PMID- 9964851 TI - Neural network training without spurious minima. PMID- 9964850 TI - Compositional segmentation and long-range fractal correlations in DNA sequences. PMID- 9964852 TI - Relativistic arbitrary-amplitude electrostatic solitons in a plasma. PMID- 9964853 TI - Statistical mechanics of magnetohydrodynamics. PMID- 9964854 TI - Coherent anti-Stokes Raman scattering performed on expanding thermal arc plasmas. PMID- 9964855 TI - Modulational instability of beat waves in a transversely magnetized plasma: Ion effects. PMID- 9964856 TI - Darwin magnetic interaction energy and its macroscopic consequences. PMID- 9964857 TI - Reemission technique for symmetry measurements in Hohlraum targets containing a centered high-Z ball. PMID- 9964858 TI - Normal modes of cold confined one-component plasmas. PMID- 9964859 TI - Effect of correlations on the thermal equilibrium and normal modes of a non neutral plasma. PMID- 9964861 TI - Effects of stochastic drifts and time variation on particle diffusion in magnetic turbulence. PMID- 9964860 TI - Isoelectronic x-ray spectroscopy to determine electron temperatures in long-scale length inertial-confinement-fusion plasmas. PMID- 9964862 TI - Space- and time-resolved ion distribution in a recombining aluminum x-ray laser plasma. PMID- 9964863 TI - Influence of ground motion on the time evolution of beams in linear colliders. PMID- 9964864 TI - Explosive amplification of an electromagnetic field in a magnetized flow of accelerated-electron oscillators. PMID- 9964866 TI - Conservation of space-charge-dominated beam emittance in a strong nonlinear focusing field. PMID- 9964865 TI - Nonlinear dynamics of intense ion beam envelopes. PMID- 9964867 TI - Stable solitons in two-component active systems. PMID- 9964868 TI - Large photonic band gaps and transmittance antiresonances in periodically modulated quasi-one-dimensional waveguides. PMID- 9964869 TI - Action at a distance as a full-value solution of Maxwell equations: The basis and application of the separated-potentials method. PMID- 9964871 TI - Dynamics of coupled gap solitons. PMID- 9964870 TI - Model for collisions in granular gases. PMID- 9964873 TI - Energy localization in a nonlinear discrete system. PMID- 9964872 TI - Quantitative characterization of turbulence in an optical experiment. PMID- 9964874 TI - Spatial dynamics of solitonlike channels near interfaces between optically linear and nonlinear media. PMID- 9964875 TI - Correlated pairs in model fermion Monte Carlo calculations. PMID- 9964876 TI - Comparative study for the calculation of the Lyapunov spectrum from nonlinear experimental signals. PMID- 9964877 TI - Method for generating long-range correlations for large systems. PMID- 9964878 TI - Visualization of the local contribution to the nodal surface of a many-fermion wave function. PMID- 9964879 TI - Lacunarity analysis: A general technique for the analysis of spatial patterns. PMID- 9964880 TI - Stochastic resonance in the Heaviside nonlinearity with white noise and arbitrary periodic signal. PMID- 9964881 TI - Chaos and noise in a truncated Toda potential. PMID- 9964882 TI - Classical limit of quantum Brownian probability. PMID- 9964884 TI - Critical exponents of the Ising model with competing Glauber and Kawasaki dynamics. PMID- 9964883 TI - Boundary-imposed spiral drift. PMID- 9964885 TI - Chemical potential: Gibbs-Duhem approach. PMID- 9964886 TI - Effects of vacancies on overshooting in nonequilibrium ordering processes. PMID- 9964887 TI - Sonoluminescence and high-pressure gas scintillators. PMID- 9964888 TI - Temperature gradients traveling with chemical waves. PMID- 9964889 TI - Stochastic dynamics of relativistic turbulence. PMID- 9964890 TI - Density dependence of the conduction-band energy V0 of excess electrons in fluid xenon. PMID- 9964891 TI - Monte Carlo simulations of random copolymers at a selective interface. PMID- 9964892 TI - Spinodal decomposition in fluids: Diffusive, viscous, and inertial regimes. PMID- 9964893 TI - Detachment energies for a negative hydrogen ion embedded in a variety of Debye plasmas. PMID- 9964894 TI - Stable multipulse states in a nonlinear dispersive cavity with parametric gain. PMID- 9964896 TI - Erratum: Potts model on the Bethe lattice with mixed interactions PMID- 9964895 TI - Generalization of Fermat's principle for photons in random media: The least mean square curvature of paths and photon diffusion on the velocity sphere. PMID- 9964898 TI - Direct calculation of invariant measures for chaotic maps. PMID- 9964897 TI - Fixed-cluster acceleration algorithm for spin systems. PMID- 9964900 TI - Symmetry-breaking bifurcation with on-off intermittency in chaotic dynamical systems. PMID- 9964899 TI - Estimating invariants of noisy attractors. PMID- 9964901 TI - Domain formation in transitions with noise and a time-dependent bifurcation parameter. PMID- 9964902 TI - Experimental properties of complexity in traffic flow. PMID- 9964904 TI - Square patterns and quasipatterns in weakly damped Faraday waves. PMID- 9964903 TI - Source of relaxation in the one-dimensional gravitating system. PMID- 9964905 TI - Evaluation of the memory kernel for fluctuation decay in simulated glass-forming Ni0.5Zr0.5 liquids. PMID- 9964907 TI - Obliquely projecting chiral alkyl chains and their precession around the long core axes in the smectic-A phase of an antiferroelectric liquid crystal. PMID- 9964906 TI - Critical behavior at the smectic-A to nematic transition confined to a random network. PMID- 9964908 TI - Surface fields and the splay-bend elastic constant. PMID- 9964910 TI - Tracer diffusion of nonspherical colloidal particles. PMID- 9964909 TI - Shear-induced behavior in a solution of cylindrical micelles. PMID- 9964911 TI - Hydrophobic hydration: Inhomogeneous water structure near nonpolar molecular solutes. PMID- 9964912 TI - Control of crystallization of ionic silica particles in aqueous dispersions by sodium hydroxide. PMID- 9964913 TI - Pulses and disorder in a continuum version of step-bunching dynamics. PMID- 9964914 TI - Shear suppression of critical fluctuations in a diluted polymer blend. PMID- 9964916 TI - One-dimensional steady-state photorefractive screening solitons. PMID- 9964915 TI - Signal separation by nonlinear projections: The fetal electrocardiogram. PMID- 9964917 TI - 1/f noise in percolation and percolationlike systems. PMID- 9964918 TI - Geometry of simulated fractures. PMID- 9964919 TI - Homoclinic dynamics in experimental Shil'nikov attractors. PMID- 9964921 TI - Effects of surface diffusion on the Eden model. PMID- 9964920 TI - Quantitative analysis of a fracture surface by atomic force microscopy. PMID- 9964922 TI - Diffusion and trapping on a one-dimensional lattice. PMID- 9964923 TI - Synchronization of symmetric chaotic systems. PMID- 9964924 TI - Rigid-body motion, interacting billiards, and billiards on curved manifolds. PMID- 9964925 TI - External fluctuations in a pattern-forming instability. PMID- 9964926 TI - Equation of state of the hard-sphere crystal. PMID- 9964927 TI - Rotated sandpiles: The role of grain reorganization and inertia. PMID- 9964928 TI - Virial expansions for quantum plasmas: Fermi-Bose statistics. PMID- 9964929 TI - Correlations within eigenvectors and transition amplitudes in the two-body random interaction model. PMID- 9964931 TI - Statistics of approximately self-affine fractals: Random corrugated surface and time series. PMID- 9964930 TI - m-vector spin glass in the presence of a Gaussian random field. PMID- 9964933 TI - Analysis by the thermodynamic formalism for an experiment of an electronic circuit. PMID- 9964932 TI - Transient properties of a bistable kinetic model with correlations between additive and multiplicative noises: Mean first-passage time. PMID- 9964935 TI - From the quantum random walk to classical mesoscopic diffusion in crystalline solids. PMID- 9964934 TI - Expected number of distinct sites visited by N Levy flights on a one-dimensional lattice. PMID- 9964936 TI - Steady-state analysis of a bistable system with additive and multiplicative noises. PMID- 9964937 TI - Asymptotic scaling behavior of block entropies for an intermittent process. PMID- 9964938 TI - Bending-rigidity-driven transition and crumpling-point scaling of lattice vesicles. PMID- 9964939 TI - Causality, response theory, and the second law of thermodynamics. PMID- 9964940 TI - Quantum evolution of a chaotic system in contact with its surroundings. PMID- 9964941 TI - Cluster-variation-Pade-approximants method and the critical exponents of the fcc Ising model. PMID- 9964942 TI - Practical implementation of error estimation for the correlation dimension. PMID- 9964943 TI - Microscopic theory for long-range spatial correlations in lattice gas automata. PMID- 9964944 TI - Finite-size scaling of the Glauber model of critical dynamics. PMID- 9964945 TI - Winding angle distributions for random walks and flux lines. PMID- 9964946 TI - Generalized Langevin equations: Anomalous diffusion and probability distributions. PMID- 9964948 TI - Quantum tunneling and stochastic resonance. PMID- 9964947 TI - Correlation functions on the border lines of transient chaos. PMID- 9964950 TI - Dynamics of an assembly of finite-size Lennard-Jones spheres. PMID- 9964949 TI - General formula for stationary or statistically homogeneous probability density functions. PMID- 9964951 TI - Dynamics of two-dimensional traveling-wave convection patterns. PMID- 9964952 TI - Density equilibration near the liquid-vapor critical point of a pure fluid. II. Coexisting phases for T PMID- 9964954 TI - Variational bounds on energy dissipation in incompressible flows. III. Convection. PMID- 9964955 TI - Nonlinear analysis of the coupling between interface deflection and hexagonal patterns in Rayleigh-Benard-Marangoni convection. PMID- 9964957 TI - Convective fingering of an autocatalytic reaction front. PMID- 9964956 TI - Spatially periodic modulated Rayleigh-Benard convection. PMID- 9964959 TI - Incomplete combustion in nonadiabatic premixed gas flames. PMID- 9964958 TI - Chaos in nonpropagating hydrodynamic solitons. PMID- 9964960 TI - Effect of coupling and linear transformation of waves in shear flows. PMID- 9964961 TI - Turbulence in globally coupled maps. PMID- 9964962 TI - Phase transitions in driven lattice gases. PMID- 9964963 TI - Percolation in a self-avoiding vortex gas model of the lambda transition in three dimensions. PMID- 9964964 TI - Influence of surface tension changes on hydrodynamic flow induced by traveling chemical waves. PMID- 9964965 TI - Coarsening dynamics of field-induced inversion domain walls in smectic-C films. PMID- 9964966 TI - Electrostriction of the cubic blue phases in the presence of bond orientational order. PMID- 9964967 TI - Generalized dynamic domain shape calculation in ferroelectric liquid crystals. PMID- 9964969 TI - Theory of light scattering by thin nematic liquid crystal films. PMID- 9964968 TI - Nonlinear dielectric relaxation spectroscopy of the antiferroelectric liquid crystal 4-(1-trifluoromethyl-pheptyloxycarbonyl) phenyl 4(')-octyloxybiphenyl-4 carboxylate. PMID- 9964970 TI - van der Waals-induced distortions in nematic liquid crystals close to a surface. PMID- 9964971 TI - Electroconvective instabilities in smectic-C* liquid crystal films. PMID- 9964972 TI - Steady-state shear experiments on a side-chain liquid-crystal polymer: Determination of the polymer conformation and liquid-crystal structure. PMID- 9964973 TI - Dynamic behaviors of fractal-like domains in monolayers. PMID- 9964975 TI - Percolation in fluid mixtures containing adhesive charged hard spheres. PMID- 9964974 TI - Rheology of gelatin solutions at the sol-gel transition. PMID- 9964976 TI - Singularity-free interpretation of the thermodynamics of supercooled water. PMID- 9964977 TI - Local order in two-dimensional colloidal aggregation. PMID- 9964978 TI - Phase transition and critical behavior in Langmuir films of myristic acid. PMID- 9964979 TI - Intrinsic conductivity of objects having arbitrary shape and conductivity. PMID- 9964980 TI - From one cell to the whole froth: A dynamical map. PMID- 9964981 TI - Double-layer capacitance on a rough metal surface. PMID- 9964983 TI - Nonexponential relaxation of density fluctuations in charge-stabilized colloids. PMID- 9964982 TI - Statistical analysis of off-lattice diffusion-limited aggregates in channel and sector geometries. PMID- 9964984 TI - Monte Carlo simulations of randomly branched polymers with annealed and quenched branching structures. PMID- 9964985 TI - Weakly nonlinear morphological instability of a cylindrical crystal growing from a pure undercooled melt. PMID- 9964986 TI - First-principles molecular dynamics of liquid alkali metals based on the quantal hypernetted chain theory. PMID- 9964987 TI - Specific heat capacity singularity and related weak anomalies in the nitroethane cyclohexane critical binary mixture. PMID- 9964988 TI - Correlated energy landscape model for finite, random heteropolymers. PMID- 9964989 TI - Statistical physics of the freely jointed chain. PMID- 9964990 TI - Collective oscillations in microtubule growth. PMID- 9964991 TI - Using phase transitions to investigate the effect of salts on protein interactions. PMID- 9964992 TI - Hidden peculiarities in the potential energy time series of a tripeptide highlighted by a recurrence plot analysis: A molecular dynamics simulation. PMID- 9964993 TI - Equivalence between learning in noisy perceptrons and tree committee machines. PMID- 9964994 TI - Entrainment and termination of reentrant wave propagation in a periodically stimulated ring of excitable media. PMID- 9964995 TI - Space of interactions with definite symmetry in neural networks with biased patterns as a spin-glass problem. PMID- 9964996 TI - Possible origin of power-law behavior in n-tuple Zipf analysis. PMID- 9964997 TI - Electromagnetic waves emitted from an electron-positron plasma cloud moving across a magnetic field. PMID- 9964998 TI - Multicomponent diffusion in two-temperature magnetohydrodynamics. PMID- 9964999 TI - Stark broadening and shift of the first two Paschen lines of hydrogen. PMID- 9965001 TI - Stability domain of planar symplectic maps using invariant manifolds. PMID- 9965000 TI - Spectroscopy of compressed high energy density matter. PMID- 9965002 TI - Measurement of subpicosecond electron pulses. PMID- 9965003 TI - Radiation generation by photoswitched, periodically biased semiconductors. PMID- 9965005 TI - Motion of three inelastic particles on a ring. PMID- 9965004 TI - Particle acceleration in an active medium. PMID- 9965006 TI - Penetration of electromagnetic velocity fields through a conducting wall of finite thickness. PMID- 9965007 TI - Theory and simulation of classical and quantum echoes. PMID- 9965008 TI - Soliton interaction in nonequilibrium dynamical systems. PMID- 9965010 TI - Multiple forward scattering of scalar waves through inhomogeneously random burstlike media. PMID- 9965009 TI - Interaction of a soliton with point impurities in an inhomogeneous, discrete nonlinear Schrodinger system. PMID- 9965011 TI - Coherent Raman response and spectral characteristics of ultrashort solitons in fibers. PMID- 9965012 TI - Stochastic model for the motion of a particle on an inclined rough plane and the onset of viscous friction. PMID- 9965013 TI - Real-time dynamics from imaginary-time quantum Monte Carlo simulations: Tests on oscillator chains. PMID- 9965014 TI - Computational model for coupled electron-photon transport in two dimensions. PMID- 9965015 TI - Electron-wave-function calculation in the continuous part of the spectrum: The case of slowly varying potential asymptotics. PMID- 9965016 TI - Multicanonical Monte Carlo study of solid-solid phase coexistence in a model colloid. PMID- 9965017 TI - Dynamical model for stretched exponential relaxation in solids. PMID- 9965018 TI - Stationary solution for the color-driven Duffing oscillator. PMID- 9965019 TI - Noise and synchronization in chaotic systems. PMID- 9965020 TI - Uncertainty in coupled chaotic systems: Locally intermingled basins of attraction. PMID- 9965021 TI - Zeros of the partition function for a continuum system at first-order transitions. PMID- 9965022 TI - Supertransient chaos in the two-dimensional complex Ginzburg-Landau equation. PMID- 9965023 TI - Synchronization of the Lorenz system through continuous feedback control. PMID- 9965024 TI - Fractal scaling of small-angle neutron scattering from nonionic micellar solutions below the cloud temperature. PMID- 9965026 TI - Scaling-violation anomaly at critical wetting. PMID- 9965025 TI - Elastic string in a random medium. PMID- 9965027 TI - Stark broadening and shift of selected neutral neon lines. PMID- 9965028 TI - Reply to "Comment on 'Exact solution of the wave dynamics of a particle bouncing chaotically on a periodically oscillating-wall"' PMID- 9965029 TI - Erratum: Cluster formation, standing waves, and stripe patterns in oscillatory active media with local and global coupling PMID- 9965030 TI - Erratum: Chaotic behavior of renormalization flow in a complex magnetic field PMID- 9965031 TI - Suppressing chaos in lasers by negative feedback. PMID- 9965033 TI - Proof of Lyapunov exponent pairing for systems at constant kinetic energy. PMID- 9965032 TI - Absence of self-averaging in global optimization problems. PMID- 9965034 TI - Instabilities on crystal surfaces: The two-component body-centered solid-on-solid model. PMID- 9965036 TI - Hard turbulence in rotating Rayleigh-Benard convection. PMID- 9965035 TI - Scaling properties of Lyapunov spectra for the band random matrix model. PMID- 9965037 TI - Early stages of ramified growth in quasi-two-dimensional electrochemical deposition. PMID- 9965038 TI - Extended self-similarity in numerical simulations of three-dimensional anisotropic turbulence. PMID- 9965039 TI - Intermittency interpretation of persistent small scale anisotropy in turbulence. PMID- 9965040 TI - Dynamics of surface patterning in salt-crystal dissolution. PMID- 9965041 TI - Normal and anomalous scaling in a problem of a passively advected magnetic field. PMID- 9965043 TI - Depinning transition of a directed polymer by a periodic potential: A d dimensional solution. PMID- 9965042 TI - Field-induced thickness change of ferroelectric liquid crystal films. PMID- 9965044 TI - Interface dynamics in a block copolymer melt and the effect of noise. PMID- 9965046 TI - Correlated random walk in continuous space. PMID- 9965045 TI - Instability of a contact surface driven by a nonuniform shock wave. PMID- 9965047 TI - Synchronization of oscillators with random nonlocal connectivity. PMID- 9965048 TI - Map with more than 100 coexisting low-period periodic attractors. PMID- 9965049 TI - Tracking unstable steady states by large periodic modulation of a control parameter in a nonlinear system. PMID- 9965051 TI - Average volume of the domain visited by randomly injected spherical Brownian particles in d dimensions. PMID- 9965050 TI - Space-time transformations within the path-integral approach to stochastic processes. PMID- 9965052 TI - Spherically symmetric random walks. I. Representation in terms of orthogonal polynomials. PMID- 9965053 TI - Spherically symmetric random walks. II. Dimensionally dependent critical behavior. PMID- 9965054 TI - Spherically symmetric random walks. III. Polymer adsorption at a hyperspherical boundary. PMID- 9965055 TI - Near-integrable systems: Resonances and semiclassical trace formulas. PMID- 9965056 TI - Growth kinetics in a phase field model with continuous symmetry. PMID- 9965057 TI - Out-of-phase mixed-mode oscillations of two strongly coupled identical relaxation oscillators. PMID- 9965058 TI - Controlling chaos in nonlinear three-wave coupling. PMID- 9965059 TI - Percolation and cluster Monte Carlo dynamics for spin models. PMID- 9965061 TI - Chaos suppression in flows using proportional pulses in the system variables. PMID- 9965060 TI - Correlation functions in the two-dimensional random-bond Ising model. PMID- 9965063 TI - Zipf's law, the central limit theorem, and the random division of the unit interval. PMID- 9965062 TI - Theory of random matrices with strong level confinement: Orthogonal polynomial approach. PMID- 9965065 TI - Sample-size dependence of the ground-state energy in a one-dimensional localization problem. PMID- 9965064 TI - Large-scale statistics of the Kuramoto-Sivashinsky equation: A wavelet-based approach. PMID- 9965066 TI - Homoclinic orbits in the Maxwell-Bloch equations with a probe. PMID- 9965067 TI - Foundation for Fisher-information-based derivations of physical laws. PMID- 9965068 TI - Spatiotemporal dynamics near a codimension-two point. PMID- 9965069 TI - Sandpile model on the Sierpinski gasket fractal. PMID- 9965070 TI - Acoustic emission from crumpling paper. PMID- 9965071 TI - Anomalous scaling behavior in a solid-on-solid model for epitaxial growth. PMID- 9965072 TI - Suppression or enhancement of quantum tunneling by a nonlinear resonance induced in a driven double-well system. PMID- 9965073 TI - Generation of non-Gaussian stationary stochastic processes. PMID- 9965075 TI - Distinct small-distance scaling behavior of on-off intermittency in chaotic dynamical systems. PMID- 9965074 TI - Directed polymers in high dimensions. PMID- 9965077 TI - Self-avoiding tethered membranes with quenched random internal disorders. PMID- 9965076 TI - Optimal periodic orbits of chaotic systems occur at low period. PMID- 9965078 TI - Surface morphology and kinetic roughening of Ag on Ag(111) studied with scanning tunneling microscopy. PMID- 9965080 TI - Average lifetime and geometric properties for superlong chaotic transients in a hybrid optical bistable system. PMID- 9965079 TI - Elastic scattering by deterministic and random fractals: Self-affinity of the diffraction spectrum. PMID- 9965081 TI - Renormalization group and singular perturbations: Multiple scales, boundary layers, and reductive perturbation theory. PMID- 9965082 TI - Anisotropy and scaling corrections in turbulence. PMID- 9965083 TI - Tortuous flow in porous media. PMID- 9965084 TI - Nonlinear analysis of coupled gravitational and capillary thermoconvention in thin fluid layers. PMID- 9965085 TI - Fragmentation of a drop as it falls in a lighter miscible fluid. PMID- 9965086 TI - Boundary-layer analysis of waves propagating in an excitable medium: Medium conditions for wave-front-obstacle separation. PMID- 9965087 TI - Monte Carlo simulation method for the Enskog equation. PMID- 9965089 TI - Local and global order in a simulated two-dimensional liquid under steady shear. PMID- 9965088 TI - Model kinetic equation for low-density granular flow. PMID- 9965090 TI - Mode-coupling effects on self-diffusion in a simple fluid at freezing. PMID- 9965092 TI - Turbulent solutal convection and surface patterning in solid dissolution. PMID- 9965091 TI - Self-similar spiral flow structure in low Reynolds number isotropic and decaying turbulence. PMID- 9965093 TI - Self-assembling electrical connections based on the principle of minimum resistance. PMID- 9965094 TI - Two-frequency parametric excitation of surface waves. PMID- 9965095 TI - Spatially quasiperiodic convection and temporal chaos in two-layer thermocapillary instabilities. PMID- 9965097 TI - Nematic surface transitions induced by anchoring competition. PMID- 9965096 TI - Spectra of single-bubble sonoluminescence in water and glycerin-water mixtures. PMID- 9965098 TI - Correlations in the thermal fluctuations of free-standing smectic-A films as measured by x-ray scattering. PMID- 9965099 TI - Thermal phase diagram of a model Hamiltonian for columnar phases of liquid crystals. PMID- 9965100 TI - Extension and generalization of the Gay-Berne potential. PMID- 9965101 TI - Effect of chirality on liquid crystals in capillary tubes with parallel and perpendicular anchoring. PMID- 9965102 TI - Disorder and order in sheared colloidal suspensions. PMID- 9965103 TI - Solute trapping effects in planar isothermal solidification of dilute binary alloys. PMID- 9965104 TI - Fractal growth of silicon-rich domains during annealing of aluminum thin films deposited on silica. PMID- 9965105 TI - Phase separation in two-dimensional binary fluids: A molecular dynamics study. PMID- 9965106 TI - Evidence for chaos in an experimental time series from serrated plastic flow. PMID- 9965107 TI - Continuum deposition of hot dimers in one dimension. PMID- 9965108 TI - Inelastic collapse of three particles. PMID- 9965110 TI - Monte Carlo study of freezing of polydisperse hard spheres. PMID- 9965109 TI - Crossover from mean field to three-dimensional Ising critical behavior in a three component microemulsion system. PMID- 9965111 TI - Molecular dynamics simulations of anomalous relaxation in a binary Lennard-Jones system. PMID- 9965112 TI - Simulation of unidirectional solidification with a tilted crystalline axis. PMID- 9965113 TI - Probing nonlocal tracer dispersion in flows through random porous media. PMID- 9965114 TI - Structure and short-time dynamics of polydisperse charge-stabilized suspensions. PMID- 9965116 TI - Dynamic scaling behavior of a growing self-affine fractal interface in a paper towel-wetting experiment. PMID- 9965115 TI - Ion transport in the fragile glass former 3KNO3-2Ca(NO3)2. PMID- 9965118 TI - Self-regulation mechanism of an ecosystem in a non-Gaussian fluctuation regime. PMID- 9965117 TI - Uncoiling transition for DNA in solution. PMID- 9965119 TI - Analytical and numerical study of internal representations in multilayer neural networks with binary weights. PMID- 9965120 TI - Relaxation dynamics in Dyson's model for the origin of metabolism. PMID- 9965121 TI - Reconstruction and structure of electrocardiogram phase portraits. PMID- 9965122 TI - Plasma broadening and shifting of spectral lines along the isoelectronic sequence of boron. PMID- 9965123 TI - One-dimensional solution for electron heating in an inductively coupled plasma discharge. PMID- 9965124 TI - Statistical properties of the dense hydrogen plasma: An ab initio molecular dynamics investigation. PMID- 9965126 TI - Effects of plasma flows on particle diffusion in stochastic magnetic fields. PMID- 9965125 TI - Instabilities and multiple steady states of radio-frequency discharges in CF4. PMID- 9965127 TI - Coupling impedance of a hole in a coaxial beam pipe. PMID- 9965128 TI - Overlapping spin synchrotron sideband resonances. PMID- 9965129 TI - Particle dynamics in quasi-isochronous storage rings. PMID- 9965130 TI - Concept of entropy in the realm of charged particle beams. PMID- 9965131 TI - Calculation of the noninertial space-charge force and the coherent synchrotron radiation force for short electron bunches in circular motion using the retarded Green's function technique. PMID- 9965132 TI - Accurate variational approach for vector solitary waves. PMID- 9965133 TI - Calculation of the rise transient and relaxation time of the induced dipole Kerr effect. PMID- 9965134 TI - Nonsmoothness, indeterminacy, and friction in two-dimensional arrays of rigid particles. PMID- 9965136 TI - Quantum corrections to the motion of classical charges in high intensity electromagnetic fields. PMID- 9965135 TI - Convective roll patterns in vertically vibrated beds of granules. PMID- 9965138 TI - Simultaneous solitary-wave solutions in a nonlinear parametric waveguide. PMID- 9965137 TI - Focused one-cycle electromagnetic pulses. PMID- 9965139 TI - Threshold effects in light scattering from a binary diffraction grating. PMID- 9965141 TI - Solution of nonlinear Fokker-Planck equations. PMID- 9965140 TI - Collapse of solitary excitations in the nonlinear Schrodinger equation with nonlinear damping and white noise. PMID- 9965142 TI - Transport of ions during ion implantation. PMID- 9965143 TI - Statistical mechanics of ideal particles in null dimension and confinement. PMID- 9965144 TI - Repeated randomness assumption and the projection operator formalism. PMID- 9965145 TI - Gaussian random eigenfunctions and spatial correlations in quantum dots. PMID- 9965146 TI - Rhythmic hopping in a one-dimensional crisis map. PMID- 9965147 TI - Experimental demonstration of delay and memory effects in the bifurcations of nickel electrodissolution. PMID- 9965148 TI - Anomalous fluctuations in low-temperature molecular dynamics simulations. PMID- 9965150 TI - Nonequilibrium phase ordering with a global conservation law. PMID- 9965149 TI - Ballistic random walker. PMID- 9965151 TI - Random sequential adsorption of k-mers on a square lattice: The large k regime. PMID- 9965153 TI - Correlation coefficients between the velocity difference and local average dissipation of turbulence. PMID- 9965152 TI - Thermodynamically self-consistent integral-equation theory for pair-correlation functions of a molecular fluid. PMID- 9965155 TI - Precursors of crystallization via density fluctuations in stiff-chain polymers. PMID- 9965154 TI - Temporal intermittency and cascades in shell models of turbulence. PMID- 9965156 TI - Dynamics of water-containing sodium bis(2-ethylhexyl)sulfosuccinate (AOT) reverse micelles: A high-frequency dielectric study. PMID- 9965158 TI - Second-harmonic generation by intense lasers in inhomogeneous plasmas. PMID- 9965157 TI - Gel formation by reversible cluster-cluster aggregation. PMID- 9965159 TI - Erratum: Head-on collision between two solitary waves in Rayleigh-Benard convecting fluid PMID- 9965160 TI - Semiclassical quantization of a separatrix map. PMID- 9965161 TI - Collective transport of particles in a "flashing" periodic potential. PMID- 9965162 TI - Driven granular media in one dimension: Correlations and equation of state. PMID- 9965163 TI - Two-dimensional late-stage coarsening for nucleation and growth at high-area fractions. PMID- 9965164 TI - Controlling spatiotemporal dynamics with time-delay feedback. PMID- 9965165 TI - Practical tests with irregular and regular finite spectra of a proposed statistical measure for quantum chaos. PMID- 9965166 TI - Crossover from XY critical to tricritical behavior of heat capacity at the smectic-A-chiral-smectic-C liquid-crystal transition. PMID- 9965167 TI - Phase equilibrium in a molecular model of a fluid confined in a disordered porous material. PMID- 9965168 TI - First-order unbinding and preunbinding in amphiphilic systems. PMID- 9965170 TI - Algorithmic complexity of a protein. PMID- 9965169 TI - Density correlations in paper. PMID- 9965171 TI - Extinction and self-organized criticality in a model of large-scale evolution. PMID- 9965172 TI - Structure and stability of the plasma crystal. PMID- 9965173 TI - Wave propagation with rotating intensity distributions. PMID- 9965174 TI - Learning algorithm that gives the Bayes generalization limit for perceptrons. PMID- 9965175 TI - Ultrametricity and memory in a solvable model of self-organized criticality. PMID- 9965177 TI - Kinetics of catalysis with surface disorder. PMID- 9965176 TI - Polymerization in a ferromagnetic spin model with threshold. PMID- 9965179 TI - Multifractality of the Lorenz system. PMID- 9965178 TI - Interface fluctuations on a hierarchical lattice. PMID- 9965180 TI - Spatial Doppler anomaly in an excitable medium. PMID- 9965182 TI - Polymers interacting with spherical and rodlike particles. PMID- 9965181 TI - Multifractality and the shattering transition in fragmentation processes. PMID- 9965183 TI - Domain growth in a one-dimensional driven diffusive system. PMID- 9965184 TI - Bidirectional shot noise in a singly occupied channel. PMID- 9965185 TI - Renormalized coupling constants and related amplitude ratios for Ising systems. PMID- 9965186 TI - Corrosion front roughening in two-dimensional pitting of aluminum thin layers. PMID- 9965188 TI - Controlling chaos using nonlinear feedback with delay. PMID- 9965187 TI - Controlling on-off intermittent dynamics. PMID- 9965189 TI - Long-range correlations in nonequilibrium systems: Lattice gas automaton approach. PMID- 9965190 TI - Oscillatory dynamics in a heterogeneous surface reaction: Breakdown of the mean field approximation. PMID- 9965191 TI - Periodic orbits in a simple ray-splitting system. PMID- 9965193 TI - Spiking in a semiconductor device: Experiments and comparison with a model. PMID- 9965192 TI - Period doublings in coupled parametrically forced damped pendulums. PMID- 9965194 TI - Theoretical approach to the correlations of a classical crystal. PMID- 9965196 TI - War: The dynamics of vicious civilizations. PMID- 9965195 TI - Self-excited soliton motion. PMID- 9965197 TI - Kinetics of fragmentation-annihilation processes. PMID- 9965198 TI - Stochastic resonance: A chaotic dynamics approach. PMID- 9965199 TI - Locally excited coupled map lattice: Phase transition from a local to a global response. PMID- 9965200 TI - Anisotropic interface depinning: Numerical results. PMID- 9965201 TI - Wave chaos in quantum billiards with a small but finite-size scatterer. PMID- 9965202 TI - Invaded cluster algorithm for Potts models. PMID- 9965203 TI - Bubbling transition. PMID- 9965205 TI - One-species bimolecular reaction kinetics enhanced by anomalous diffusion. PMID- 9965204 TI - Synchronization of chaotic systems and on-off intermittency. PMID- 9965206 TI - Chaotic-to-regular transition in a semiclassical electron gas. PMID- 9965207 TI - Canonical partition functions for parastatistical systems of any order. PMID- 9965208 TI - Effects of long-ranged interactions on the nucleation dynamics in a phi6 model. PMID- 9965210 TI - Dynamical features of a classically chaotic quantum system: Symmetry breaking and the disappearance of the squeezing effect. PMID- 9965209 TI - Nonlinear quantum stochastic resonance. PMID- 9965211 TI - Theory of extremal dynamics with quenched disorder: Invasion percolation and related models. PMID- 9965212 TI - Renormalization procedure for directed self-organized critical models. PMID- 9965213 TI - Exact time evolution of the density of a classical many-body system: The open one dimensional gravitational gas. PMID- 9965214 TI - Bond percolation on a dilute lattice with short and long range correlations: A numerical simulation. PMID- 9965215 TI - Quantum suppression of chaos in the spin-boson model. PMID- 9965216 TI - Brownian motion with the exposure time control. PMID- 9965217 TI - Efficient and accurate calculations of stability bounds in Hamiltonian systems. PMID- 9965218 TI - Coarsening dynamics of falling-film solitary waves. PMID- 9965219 TI - Amplitude equations and pattern selection in viscoelastic convection. PMID- 9965220 TI - Spreading of a macroscopic lattice gas. PMID- 9965221 TI - Intermittency and anomalous scaling of passive scalars in any space dimension. PMID- 9965222 TI - Increase in chaotic motions of atoms in a large-scale self-organized motion. PMID- 9965224 TI - Sufficient condition for a finite-time singularity in a high-symmetry Euler flow: Analysis and statistics. PMID- 9965223 TI - Influence of through-flow on linear pattern formation properties in binary mixture convection. PMID- 9965225 TI - Entropy of glassy polymer melts: Comparison between Gibbs-DiMarzio theory and simulation. PMID- 9965227 TI - Three-dimensional perturbations in conformal turbulence. PMID- 9965226 TI - Adiabatic versus conductive heat transfer in off-critical SF6 in the absence of convection. PMID- 9965228 TI - Fronts between hexagons and squares in a generalized Swift-Hohenberg equation. PMID- 9965229 TI - Onset and evolution of the tilted smectic antiphase in a polar liquid-crystal binary mixture. PMID- 9965230 TI - Pattern formation during mesophase growth in a homologous series. PMID- 9965231 TI - Nature of the smectic-A-smectic-C transition of a partially perfluorinated compound. PMID- 9965233 TI - Model of liquid crystal alignment by exposure to linearly polarized ultraviolet light. PMID- 9965232 TI - Nematic order director fluctuations in cylindrical capillaries. PMID- 9965234 TI - Anisotropic heat transport in the octylcyanobiphenyl (8CB) liquid crystal. PMID- 9965235 TI - Smectic-A structures in submicrometer cylindrical cavities. PMID- 9965236 TI - Behavior of the director reorientation time in glass surfaces of lyotropic liquid crystals in the nematic to biaxial transition. PMID- 9965238 TI - Radial distribution of the end-to-end distance of linear stiff chains. PMID- 9965237 TI - Growth-direction dependence of steady-state Saffman-Taylor flow in an anisotropic Hele-Shaw cell. PMID- 9965239 TI - Natural convection in droplet evaporation. PMID- 9965241 TI - Consequences of kinetic inhomogeneities in glasses. PMID- 9965240 TI - Monte Carlo simulation of polymerization-induced phase separation. PMID- 9965243 TI - Connection of microstructure to rheology in a microemulsion model. PMID- 9965242 TI - Surface tension of the polymer network of a gel. PMID- 9965245 TI - Density-functional theory for the freezing of Stockmayer fluids. PMID- 9965244 TI - Phase transitions in Langmuir films of fatty acids: L2-L2'-L2" triple point and order of the transitions. PMID- 9965246 TI - Relationship between the microstructure and rheology of micellar solutions formed by a triblock copolymer surfactant. PMID- 9965248 TI - Fluctuating hydrodynamic models for supercooled liquids and development of long relaxation times. PMID- 9965247 TI - Simple hydrodynamic model of fast-mode kinetics in surface-mediated fluid phase separation. PMID- 9965250 TI - Raman studies of three-dimensional foam. PMID- 9965249 TI - Dynamical properties of water-methanol solutions studied by depolarized Rayleigh scattering. PMID- 9965251 TI - Multiscale geometrical reconstruction of porous structures. PMID- 9965252 TI - Branched polymers in the presence of impurities. PMID- 9965253 TI - Measurement of the interactions between two ordering surfaces under symmetric and asymmetric boundary conditions. PMID- 9965254 TI - Shear-induced distortion of intramolecular and intermolecular correlations in liquids: Time-dependent density-functional theory. PMID- 9965255 TI - Shear response of Langmuir monolayers of heneicosanoic (C21) acid studied using a torsion pendulum. PMID- 9965256 TI - Swelling behavior and local topology of an L3 (sponge) phase. PMID- 9965258 TI - Diffusion measurements in oriented phospholipid bilayers by 1H-NMR in a static fringe field gradient. PMID- 9965257 TI - Statistical properties of heartbeat intervals during atrial fibrillation. PMID- 9965259 TI - Formation of complex bacterial colonies via self-generated vortices. PMID- 9965261 TI - Generalization in a two-layer neural network with multiple outputs. PMID- 9965260 TI - Temperature-induced sol-gel transition and microgel formation in alpha -actinin cross-linked actin networks: A rheological study. PMID- 9965262 TI - Dynamics of cytoskeletal filaments. PMID- 9965263 TI - Fast penetration of a magnetic field into a collisionless plasma. PMID- 9965264 TI - Spatiotemporal patterning of a transverse ionization instability in annular rf discharges. PMID- 9965265 TI - Inverse Faraday effect and propagation of circularly polarized intense laser beams in plasmas. PMID- 9965266 TI - Maxwell and non-Maxwell behavior of electron energy distribution function under expanding plasma jet conditions: The role of electron-electron, electron-ion, and superelastic electronic collisions under stationary and time-dependent conditions. PMID- 9965267 TI - Photoelectric effect in the super transition array model. PMID- 9965268 TI - Low-frequency percolation scaling for particle diffusion in electrostatic turbulence. PMID- 9965269 TI - Anomalous penetration mechanisms of very intense laser pulses into overdense plasmas. PMID- 9965270 TI - Optical and mass spectrometric investigations of ions and neutral species in SF6 radio-frequency discharges. PMID- 9965271 TI - Three-body recombination rate of atomic nitrogen in low-pressure plasma flows. PMID- 9965272 TI - Plasma and liquid-metal resistivity calculations using the Ziman theory. PMID- 9965273 TI - Langmuir probe measurements in an expanding magnetized plasma. PMID- 9965274 TI - Bremsstrahlung in electron-ion Coulomb scattering in strongly coupled plasma using the hyperbolic-orbit trajectory method. PMID- 9965276 TI - Frequency dependence of the penetration of electromagnetic fields through an elliptical hole in a thin metallic wall. PMID- 9965275 TI - Microwave inverse C-caronerenkov accelerator. PMID- 9965277 TI - Emittance optimization in three- and multiple-bend achromats. PMID- 9965278 TI - Transport properties of arrays of elliptical cylinders. PMID- 9965279 TI - Propagation of waves through a line of discontinuity in two-dimensional excitable media: Refraction and reflection of autowaves. PMID- 9965281 TI - Effect of size polydispersity on granular materials. PMID- 9965280 TI - Coupled-mode theory for light propagation through deep nonlinear gratings. PMID- 9965283 TI - Anomalous density dependence of static friction in sand. PMID- 9965282 TI - Spectral characteristics in resonators with fractal boundaries. PMID- 9965284 TI - Intrinsic localized modes as solitons of the discrete Hirota equation. PMID- 9965285 TI - Instability-induced dynamics of dark solitons. PMID- 9965286 TI - Bifurcation of the periodic orbits of Hamiltonian systems: An analysis using normal form theory. PMID- 9965287 TI - Nonlinear effects in molecular chains with two types of intramolecular vibrations. PMID- 9965288 TI - Classical kinetic theory simulations using smoothed particle hydrodynamics. PMID- 9965289 TI - Exact numerical simulation of the Ornstein-Uhlenbeck process and its integral. PMID- 9965290 TI - Two-dimensional effects in Josephson junctions: Static properties. PMID- 9965291 TI - Systematic generation of constituent models of particle families. PMID- 9965292 TI - Interface roughening with nonlinear surface tension. PMID- 9965293 TI - Experimental observation of phase synchronization. PMID- 9965294 TI - Goal-oriented scheme for taming chaos with a weak periodic perturbation: Experiment in a diode resonator. PMID- 9965295 TI - Lyapunov exponents of random time series. PMID- 9965297 TI - Driving and synchronizing by chaotic impulses. PMID- 9965296 TI - Prehistory problem for systems driven by white noise. PMID- 9965298 TI - Dynamical evolution of squeezing and antibunching effects in a quantum chaotic system: The three-level Lipkin model. PMID- 9965299 TI - Towards a statistical theory of finite Fermi systems and compound states: Random two-body interaction approach. PMID- 9965300 TI - Autocatalysis in a shear flow. PMID- 9965302 TI - Nonlinear heat conduction in gases. PMID- 9965301 TI - Calculation of extended electronic states in simple liquids and plasmas. PMID- 9965303 TI - Behavior of the Goldstone mode in smectic-C* phase and the soft mode in the smectic-C* and smectic-A* phases of a ferroelectric liquid-crystal mixture. PMID- 9965305 TI - Anomalous transport reduction via feedback suppression. PMID- 9965304 TI - Multiscaled randomness: A possible source of 1/f noise in biology. PMID- 9965306 TI - Indirect and direct laser driven shock waves and applications to copper equation of state measurements in the 10-40 Mbar pressure range. PMID- 9965308 TI - Sign ambiguity in configuration mixing and coupled channel calculations. PMID- 9965307 TI - Ionization-induced blue shift of KrF laser pulses in an underdense plasma. PMID- 9965309 TI - Erratum: Quantum transition-state theory below the crossover temperature PMID- 9965310 TI - Word processors with line wrap: Cascading, self-organized criticality, random walks, diffusion, and predictability. PMID- 9965311 TI - Thermodynamic formalism in the thermodynamic limit: Diffusive systems with static disorder. PMID- 9965312 TI - Cyclic XY model and exotic statistics in one dimension. PMID- 9965313 TI - Diffusion in disordered media as a process with memory. PMID- 9965314 TI - Phase transitions near the "game of Life" PMID- 9965315 TI - Multiple magnetization paths in Barkhausen noise. PMID- 9965316 TI - Intensity fluctuations in closed and open systems. PMID- 9965317 TI - Suppressing large excursions to a chaotic attractor using occasional feedback control. PMID- 9965318 TI - Motion of the reaction front in the A+B-->C reaction-diffusion system. PMID- 9965319 TI - Periodic orbits and spectral statistics of pseudointegrable billiards. PMID- 9965320 TI - Boundary-induced wavelength selection in a one-dimensional pattern-forming system. PMID- 9965321 TI - Localized spatiotemporal chaos in surface waves. PMID- 9965322 TI - Scaling model of annihilation-diffusion kinetics for charged particles with long range interactions. PMID- 9965324 TI - Nonequilibrium effects on slow dynamics in concentrated colloidal suspensions. PMID- 9965323 TI - Specific heat relaxation during macromolecule growth. PMID- 9965325 TI - Influence of electron collisions on the resonance cone phenomenon in a cold magnetized plasma. PMID- 9965326 TI - Electron acceleration by a laser pulse in a plasma. PMID- 9965327 TI - Instability of the current sheath implosion in an 18-kJ Mather-type plasma focus. PMID- 9965328 TI - Ultrashort pulse propagation at the photonic band edge: Large tunable group delay with minimal distortion and loss. PMID- 9965330 TI - Dynamic scaling of the width distribution in Edwards-Wilkinson type models of interface dynamics. PMID- 9965329 TI - Single-particle survival in gated trapping. PMID- 9965331 TI - Kinetic grain model for sandpiles. PMID- 9965332 TI - Nonequilibrium structure factor for conserved spin dynamics: Abrupt temperature increase. PMID- 9965333 TI - Numerical computation of finite size scaling functions: An alternative approach to finite size scaling. PMID- 9965334 TI - Validity of the mean-field approximation for diffusion on a random comb. PMID- 9965335 TI - Chaotic dynamics in a three-dimensional superconducting microwave billiard. PMID- 9965337 TI - Universal evolution to equipartition in oscillator chains. PMID- 9965336 TI - Structure-property correlations in model composite materials. PMID- 9965338 TI - Synchronization of integrate and fire oscillators with global coupling. PMID- 9965339 TI - Mean-field behavior of cluster dynamics. PMID- 9965340 TI - Theory of quantum fluctuations in classically chaotic Hamiltonian systems. PMID- 9965341 TI - Resonant subharmonic absorption and second-harmonic generation by a fluctuating nonlinear oscillator. PMID- 9965342 TI - Some dynamical aspects of the water drop formation in a leaky faucet. PMID- 9965343 TI - Inverse problem with a dilated kernel containing different singularities. PMID- 9965344 TI - Complete phase locking in modulated relaxation oscillators described by a nonsmooth circle map: Positive fractal dimension of the complementary set of phase-locked regions. PMID- 9965345 TI - Thermal conduction in a quantum system. PMID- 9965346 TI - Two-dimensional cellular automaton model of traffic flow with open boundaries. PMID- 9965348 TI - Classical and quantum chaos in a quantum dot in time-periodic magnetic fields. PMID- 9965347 TI - Discrete basis representation of Ursell operators. PMID- 9965350 TI - Statistical properties of random scattering matrices. PMID- 9965349 TI - Multifractal analysis of the atomic spectral line series. PMID- 9965351 TI - Experimental study of a crossover from nonclassical to classical chemical kinetics: An elementary and reversible A+B C reaction-diffusion process in a capillary. PMID- 9965352 TI - Coulombic phase transitions in symmetrical quantum systems. PMID- 9965353 TI - Distribution of zeros of the Husimi function in a realistic Hamiltonian molecular system. PMID- 9965354 TI - Algebraic relaxation of classical particles in one-dimensional anharmonic potentials: Analytical proof. PMID- 9965355 TI - Synchronized spatiotemporal chaos and spatiotemporal on-off intermittency in a nonlinear ring cavity. PMID- 9965356 TI - Statistical approach to nonhyperbolic chaotic systems. PMID- 9965357 TI - One temperature step away from the critical point. PMID- 9965358 TI - Self-organized branching processes: Avalanche models with dissipation. PMID- 9965359 TI - Observation of intermingled basins in coupled oscillators exhibiting synchronized chaos. PMID- 9965360 TI - Hamiltonian formulation of the Gaussian isokinetic thermostat. PMID- 9965361 TI - Irreversible processes and temperature. PMID- 9965362 TI - Distribution of domain sizes in the zero temperature Glauber dynamics of the one dimensional Potts model. PMID- 9965363 TI - Modification of linear response theory for mean-field approximations. PMID- 9965364 TI - Barkhausen noise: Elementary signals, power laws, and scaling relations. PMID- 9965365 TI - Effective boundary extrapolation length to account for finite-size effects in the percolation crossing function. PMID- 9965366 TI - Asymptotic states of decaying turbulence in two-dimensional incompressible flows. PMID- 9965367 TI - Anomalous scaling in the N-point functions of a passive scalar. PMID- 9965368 TI - Induced burst of fluid drops in a two-component lattice Bhatnager-Gross-Krook fluid. PMID- 9965369 TI - Dependence of the dynamical factor in nucleation rates on heat conduction and viscosity. PMID- 9965370 TI - Symmetry-breaking bifurcations for the magnetohydrodynamic equations with helical forcing. PMID- 9965372 TI - Dissipation fluctuations of a passive scalar advected by a random velocity field. PMID- 9965371 TI - Structure of strongly dipolar fluids at low densities. PMID- 9965373 TI - Turbulence cascades across equilibrium spectra. PMID- 9965374 TI - Pattern formation and evolution near autocatalytic reaction fronts in a narrow vertical slab. PMID- 9965375 TI - Waiting-time solutions of a nonlinear diffusion equation: Experimental study of a creeping flow near a waiting front. PMID- 9965376 TI - Stimulated Raman scattering produced by self-focusing in liquid crystals. PMID- 9965377 TI - Monte Carlo study of liquid-crystal ordering in the independent-pore model of aerogels. PMID- 9965378 TI - Persistence length of the Debye-Huckel model of weakly charged flexible polyelectrolyte chains. PMID- 9965380 TI - Discrete solid-on-solid model of interface with bending rigidity: Roughening versus crumpling. PMID- 9965379 TI - Structure and transport properties of a porous magnetic gel via x-ray microtomography. PMID- 9965381 TI - Swelling and growth of polymers, membranes, and sponges. PMID- 9965382 TI - Stability of densely branched growth in dissipative diffusion-controlled systems. PMID- 9965383 TI - Pressure-induced reentrant phase behavior in the poly(N-vinyl-2-pyrrolidone) water system. PMID- 9965384 TI - Short-time dynamics of colloidal suspensions. PMID- 9965385 TI - Structure formation and the morphology diagram of possible structures in two dimensional diffusional growth. PMID- 9965386 TI - Effective chi in a lattice theory of mixtures. PMID- 9965387 TI - Ellipsometric study of critical adsorption and measurement of universal surface integrals. PMID- 9965388 TI - Fluid-solid equilibrium of a charged hard-sphere model. PMID- 9965389 TI - Simple theory for volume phase transition of hydrated gels. PMID- 9965390 TI - Topological simulations of dynamical features in coarsening soap froth. PMID- 9965392 TI - Shape fluctuations of droplets in emulsions. PMID- 9965391 TI - Structure factor of compressed liquid deuterium close to the melting transition. PMID- 9965393 TI - Application of mode-coupling theory to solvation dynamics. PMID- 9965394 TI - Phase-field model of spiral dendritic growth. PMID- 9965395 TI - Chaos and associative generation of information by networks of neuronal oscillators. PMID- 9965396 TI - Phase diagrams of self-organizing maps. PMID- 9965397 TI - Entropically driven segregation in blends of branched and linear polymers. PMID- 9965398 TI - Polygonal shape transformation of a circular biconcave vesicle induced by osmotic pressure. PMID- 9965399 TI - Equation of state and correlation functions of strongly coupled plasma mixtures: Density functional theory and analytic models. PMID- 9965400 TI - Type-I-like intermittent chaos in multicomponent plasmas with negative ions. PMID- 9965401 TI - Electrical conductivities for hot, dense hydrogen. PMID- 9965402 TI - Spectroscopic characterization of prepulsed x-ray laser plasmas. PMID- 9965403 TI - Absence of magnetohydrodynamic activity in the voltage-driven sheet pinch. PMID- 9965404 TI - Analytical theory of arbitrary-order achromats. PMID- 9965405 TI - Image effects of cylindrical pipes on continuous beams. PMID- 9965406 TI - Microwave instability beyond threshold. PMID- 9965407 TI - Polarization conversion from diffraction gratings made of uniaxial crystals. PMID- 9965408 TI - Perturbation analysis of weakly discrete kinks. PMID- 9965409 TI - Green dyadics in reciprocal uniaxial bianisotropic media by cylindrical vector wave functions. PMID- 9965410 TI - Phenomenological modeling of the compaction dynamics of shaken granular systems. PMID- 9965411 TI - Wave-function method used to study the Bethe coupler. PMID- 9965412 TI - Optical solitons with power-law asymptotics. PMID- 9965413 TI - Solitons in a class of systems of two coupled real scalar fields. PMID- 9965414 TI - Exact soliton solutions to coupled nonlinear Schrodinger equations with higher order effects. PMID- 9965416 TI - Resonance mode expansions and exact solutions for nonuniform gratings. PMID- 9965415 TI - Spectral analysis of the nonlinear relativistic Doppler shift in ultrahigh intensity Compton scattering. PMID- 9965417 TI - Multiple-time higher-order perturbation analysis of the regularized long wavelength equation. PMID- 9965419 TI - Inductive instability in conductors with a moving front of electric conductivity jump. PMID- 9965418 TI - Analytic calculation of the aftereffect solution and correlation time of the induced dipole Kerr effect. PMID- 9965421 TI - Cutoff frequency of experimentally generated noise: A Melnikov approach. PMID- 9965420 TI - Long-term vortex interaction in active media. PMID- 9965422 TI - Two-component spreading phenomena: Why the geometry makes the criticality. PMID- 9965423 TI - Chemical wave refraction phenomena. PMID- 9965424 TI - Strong nonlinear dynamic rupture theory of thin liquid films. PMID- 9965425 TI - Self-organization of two-dimensional incompressible viscous flow in a friction free box. PMID- 9965426 TI - Effects of a changing temperature on the nucleation rate. PMID- 9965427 TI - Modulations in the diffracted intensity in chiral smectic-C liquid crystals. PMID- 9965429 TI - Glass phase of randomly polymerized membranes. PMID- 9965428 TI - Temperature-dependent phase transitions in water-oil-surfactant mixtures: Experiment and theory. PMID- 9965430 TI - Fractal dynamics in orthokinetic acoustic agglomeration processes. PMID- 9965431 TI - Effect of van der Waals surface interactions on wetting transitions in polymer blends. PMID- 9965432 TI - Different molecular size scaling regimes for inner and outer regions of proteins. PMID- 9965433 TI - Head-on collisions of dark solitons near the zero-dispersion point in optical fibers. PMID- 9965435 TI - Erratum: Phase equilibria in solutions of disklike particles PMID- 9965434 TI - Nondiffractive fields. PMID- 9965436 TI - Stress-free spatial anisotropy in phase ordering. PMID- 9965437 TI - Threshold detection of wideband signals: A noise-induced maximum in the mutual information. PMID- 9965438 TI - Lack of self-affinity and anomalous roughening in growth processes. PMID- 9965439 TI - Phase transitions in nonlinear oscillator chains. PMID- 9965440 TI - Anomalous diffusion in the presence of external forces: Exact time-dependent solutions and their thermostatistical basis. PMID- 9965441 TI - Roundoff-induced coalescence of chaotic trajectories. PMID- 9965442 TI - Angular correlations in sonoluminescence: Diagnostic for the sphericity of a collapsing bubble. PMID- 9965443 TI - Kramers equation as a model for semiflexible polymers. PMID- 9965445 TI - Preservation of droplet collision history in phase separation of a binary fluid mixture. PMID- 9965444 TI - Phase segregation dynamics of a chemically reactive binary mixture. PMID- 9965446 TI - Anomalous phase separation dynamics in the presence of surfactants. PMID- 9965447 TI - Delay-induced transitions in visually guided movements. PMID- 9965448 TI - Information measures quantifying aperiodic stochastic resonance. PMID- 9965450 TI - Particle ordered structures in a strongly coupled classical thermal plasma. PMID- 9965449 TI - Low-frequency electrostatic waves in a hot magnetized dusty plasma. PMID- 9965451 TI - Polarization of impurity emission lines from a tokamak plasma. PMID- 9965452 TI - Multisoliton collisions in nearly integrable systems. PMID- 9965453 TI - Long-range correlations in permeability fluctuations in porous rock. PMID- 9965454 TI - Dynamical effects of partial orderings in physical systems. PMID- 9965455 TI - Higher-order finite-element distributions in statistical theory of nuclear spectra. PMID- 9965456 TI - Effect of chaotic noise on multistable systems. PMID- 9965458 TI - Motion of a driven tracer particle in a one-dimensional symmetric lattice gas. PMID- 9965457 TI - Defects in self-organized criticality: A directed coupled map lattice model. PMID- 9965459 TI - Escape over a fluctuating barrier: Limits of small and large correlation times. PMID- 9965460 TI - Braids on the Poincare section: A laser example. PMID- 9965461 TI - One-dimensional map lattices: Synchronization, bifurcations, and chaotic structures. PMID- 9965463 TI - Global scaling behaviors and chaotic measure characterized by the convergent rates of period-p-tupling bifurcations. PMID- 9965462 TI - Control of chaos in noisy flows. PMID- 9965464 TI - Transition from localized to extended eigenstates in the ensemble of power-law random banded matrices. PMID- 9965465 TI - Strange nonchaotic attractors in autonomous and periodically driven systems. PMID- 9965466 TI - Coherent-ordered transition in chaotic globally coupled maps. PMID- 9965467 TI - Low-dimensional phase-locked states in the Zakharov equations. PMID- 9965468 TI - Integral relaxation time of single-domain ferromagnetic particles. PMID- 9965469 TI - Kinetics of phase ordering in the two-dimensional coupled XY-Ising model. PMID- 9965470 TI - Regular and irregular features of classical motion described by a quadrupole boson Hamiltonian. PMID- 9965471 TI - Kinetic equations for a nonideal quantum system. PMID- 9965473 TI - Nearest-neighbor-spacing distribution of a system with many degrees of freedom, some regular and some chaotic. PMID- 9965472 TI - Different types of chaos synchronization in two coupled piecewise linear maps. PMID- 9965474 TI - Scale anomaly and quantum chaos in billiards with pointlike scatterers. PMID- 9965475 TI - Validity of basic concepts in nonlinear cooperative Fokker-Planck models. PMID- 9965476 TI - Complex fiber bundle model for optimization of heterogeneous materials. PMID- 9965477 TI - Multiplicity distributions in binary fragmenting with inhibition at the transition line. PMID- 9965478 TI - Parallel Bak-Sneppen model and directed percolation. PMID- 9965480 TI - Stochastic localization. PMID- 9965479 TI - Decay rates of resonance states at high level density. PMID- 9965481 TI - Coupled chaotic chemical oscillators. PMID- 9965482 TI - Self-replication and splitting of domain patterns in reaction-diffusion systems with the fast inhibitor. PMID- 9965483 TI - Degree of synchronization of noisy maps on the circle. PMID- 9965485 TI - Period p-tuplings in coupled maps. PMID- 9965484 TI - Critical exponents of a two-dimensional continuum percolation system. PMID- 9965486 TI - Action principle in nonequilibrium statistical dynamics. PMID- 9965487 TI - Irreversible phase transitions in contact processes with Levy exchanges and long range interactions. PMID- 9965488 TI - Statistical mechanics of cracks. PMID- 9965489 TI - Stabilizing unstable periodic points of one-dimensional nonlinear systems using delayed-feedback signals. PMID- 9965490 TI - Chaos in the relativistic cyclotron motion of a charged particle. PMID- 9965492 TI - Resonant activation in a bistable system. PMID- 9965491 TI - Random matrix approach to quantum dissipation. PMID- 9965494 TI - Microcanonical fluctuations of a Bose system's ground state occupation number. PMID- 9965493 TI - Testing predictability criteria in avalanches. PMID- 9965495 TI - Static and dynamic epidemics on looped chains and looped trees. PMID- 9965496 TI - Extrinsic effects on the disorder dynamics of Benard-Marangoni patterns. PMID- 9965497 TI - Analytical properties of the quadratic density response and quadratic dynamical structure functions: Conservation sum rules and frequency moments. PMID- 9965499 TI - Noise-induced phase transitions in a pendulum with a randomly vibrating suspension axis. PMID- 9965498 TI - On-off intermittency in random map lattices driven by fractal noise. PMID- 9965500 TI - Neural network model to control an experimental chaotic pendulum. PMID- 9965501 TI - Transitional aggregation kinetics in dry and damp environments. PMID- 9965502 TI - Nucleation and growth in one dimension. PMID- 9965503 TI - Deconvolution of Rutherford backscattering spectra: An inverse problem. PMID- 9965504 TI - Noisy Kuramoto-Sivashinsky equation for an erosion model. PMID- 9965506 TI - Semiclassical level curvatures and quantum transport phenomena. PMID- 9965505 TI - Observation of the concurrent creation and annihilation of periodic orbits in a nonlinear RLC circuit. PMID- 9965507 TI - Critical dimensions for random walks on random-walk chains. PMID- 9965509 TI - Diffusion in a multicomponent lattice Boltzmann equation model. PMID- 9965508 TI - Benard-Marangoni convection in square containers. PMID- 9965511 TI - Green's functions for a system with a thin membrane. PMID- 9965510 TI - Well-posed Boussinesq paradigm with purely spatial higher-order derivatives. PMID- 9965512 TI - Experimental study of self-sustained oscillations in a confined jet. PMID- 9965514 TI - Transition between viscous and inertial-range scaling of turbulence structure functions. PMID- 9965513 TI - Time correlation functions of classical fluids: A self-consistent approach. PMID- 9965516 TI - Magnetic fluid under vorticity: Free precession decay of magnetization and optical anisotropy. PMID- 9965515 TI - Homogeneous cooling state of a low-density granular flow. PMID- 9965517 TI - Rayleigh-Taylor instability in finite-thickness fluids with viscosity and surface tension. PMID- 9965518 TI - Vortex-sink dynamics. PMID- 9965519 TI - Statistical mechanics of deformable molecular liquids: Thermal expansion and isomerization of diatomic molecules. PMID- 9965521 TI - Continuous limit of the Nagel-Schreckenberg model. PMID- 9965520 TI - Orientational relaxation in a random dipolar lattice: Wave-number and frequency dependence. PMID- 9965522 TI - Propagation of curved stationary flames in tubes. PMID- 9965523 TI - Irreversible adsorption of particles after diffusing in a gravitational field. PMID- 9965524 TI - Turbulent Rayleigh-Taylor instability experiments with variable acceleration. PMID- 9965525 TI - Modulated electrochemical waves. PMID- 9965526 TI - Surface-tension-gradient-induced flow in freely suspended liquid crystalline films. PMID- 9965527 TI - Periodic distortions in lyotropic nematic calamitic liquid crystals. PMID- 9965528 TI - Structure of the cholesteric focal conic domains at the free surface. PMID- 9965529 TI - Landau-de Gennes theory of the chevron structure in a smectic liquid crystal. PMID- 9965531 TI - Dynamical behavior of microemulsion and sponge phases in thermal equilibrium. PMID- 9965530 TI - Wetting description of block copolymer thin films. PMID- 9965532 TI - Spreading of a thin wetting film: Microscopic approach. PMID- 9965533 TI - Dynamic response of a magnetic suspension in a viscoelastic fluid. PMID- 9965534 TI - Merging of the alpha and beta relaxations in polybutadiene: A neutron spin echo and dielectric study. PMID- 9965535 TI - Scaling properties of a percolation model with long-range correlations. PMID- 9965536 TI - Two-dimensional dynamics of a free molecular chain with a secondary structure. PMID- 9965537 TI - Phase ordering kinetics in the Swift-Hohenberg equation. PMID- 9965539 TI - Thermal fluctuations in supercrystal stripe phases of Langmuir monolayers. PMID- 9965538 TI - Adsorption of polymers at interfaces and extended defects. PMID- 9965540 TI - Density functional theory for the phase diagram of rigid C60 molecules. PMID- 9965541 TI - Stochastic equations for simple discrete models of epitaxial growth. PMID- 9965542 TI - Universality of gelation: End-linking versus cross-linking and stiff rods versus flexible chains. PMID- 9965543 TI - Effect of the attractive potential of a drop in vapor phase nucleation. PMID- 9965544 TI - Dynamics of semiflexible and rigid particles. I. The velocity distribution and the Smoluchowski equation. PMID- 9965545 TI - Dynamics of semiflexible and rigid particles. II. Derivation of the stress tensor and transport equations. PMID- 9965546 TI - Bending of ionic surfactant monolayers. PMID- 9965547 TI - Penetrant diffusion in frozen polymer matrices: A finite-size scaling study of free volume percolation. PMID- 9965548 TI - High-pressure and temperature dependence of dielectric relaxation in supercooled di-isobutyl phthalate. PMID- 9965549 TI - Simple model for deep bed filtration. PMID- 9965551 TI - Lineal measures of clustering in overlapping particle systems. PMID- 9965550 TI - Surface roughness of sputtered ZrO2 films studied by atomic force microscopy and spectroscopic light scattering. PMID- 9965552 TI - Random walks on random partitions in one dimension. PMID- 9965553 TI - Population genetics approach to the quasispecies model. PMID- 9965554 TI - Neuronal populations with reciprocal inhibition and rebound currents: Effects of synaptic and threshold noise. PMID- 9965555 TI - Inference and chaos by a network of nonmonotonic neurons. PMID- 9965556 TI - Kinetics of a Gaussian random copolymer as a prototype for protein folding. PMID- 9965558 TI - Second-harmonic generation of Raman scattered light in a plasma channel. PMID- 9965557 TI - Electric field dynamics at a charged point. PMID- 9965559 TI - Energy loss of correlated ions in plasmas: Collective and individual contributions. PMID- 9965560 TI - Parametric decay of Alfven waves in multicomponent plasmas. PMID- 9965561 TI - Ecologically safe regimes of generation and maintenance of artificial ionized regions in the stratosphere by microwave radiation. PMID- 9965562 TI - Stopping power in nonideal and strongly coupled plasmas. PMID- 9965564 TI - Alignment and instability of dust crystals in plasmas. PMID- 9965563 TI - Stark broadening of satellite lines in silicon plasmas driven by femtosecond laser pulses. PMID- 9965565 TI - Absorption and hot electron production by high intensity femtosecond uv-laser pulses in solid targets. PMID- 9965567 TI - Longitudinal current losses in rf linear accelerators. PMID- 9965566 TI - Single-mode selection and axial mode control in a free-electron maser oscillator using a prebunched electron beam. PMID- 9965568 TI - Role of parametric resonances in global chaos. PMID- 9965569 TI - Chaotic dynamics induced by space-charge waves in cyclotron resonance accelerators. PMID- 9965570 TI - Self-guiding and stability of intense optical beams in gases undergoing ionization. PMID- 9965571 TI - Heavy-ion partial beam lifetimes due to Coulomb induced processes. PMID- 9965572 TI - Tracking algorithm for the stable spin polarization field in storage rings using stroboscopic averaging. PMID- 9965573 TI - Light diffusion with gain and random lasers. PMID- 9965574 TI - Second-harmonic generation in diatomic lattices. PMID- 9965575 TI - Parametric amplification of short pulses in optical fiber Bragg gratings. PMID- 9965576 TI - Computing the optical near-field distributions around complex subwavelength surface structures: A comparative study of different methods. PMID- 9965577 TI - Patterns and scaling in surface fragmentation processes. PMID- 9965578 TI - Existence of solitary solutions in nonlinear chains. PMID- 9965579 TI - Traveling-wave solutions of the cubic-quintic nonlinear Schrodinger equation. PMID- 9965580 TI - Origin of the persistent oscillations of solitary waves in nonlinear quadratic media. PMID- 9965581 TI - Kink internal modes in discrete nonlinear chains. PMID- 9965582 TI - Two-dimensional granular flow in a small-angle funnel. PMID- 9965583 TI - Nonspiral excitation waves beyond the eikonal approximation. PMID- 9965585 TI - Electromagnetic scattering in two-dimensional dissipative systems without localization. PMID- 9965584 TI - Angular-spectrum representation of nondiffracting PMID- 9965586 TI - Energy balance equation for electromagnetic waves in bianisotropic media. PMID- 9965587 TI - B or H as the basic field in electromagnetism. PMID- 9965589 TI - Biaxial nonlinear surface waves. PMID- 9965588 TI - Stability and interactions of solitons in two-component active systems. PMID- 9965590 TI - Lattice Boltzmann algorithm for three-dimensional simulations of plasma turbulence. PMID- 9965591 TI - Adaptation and linear-response theory. PMID- 9965592 TI - Collective degrees of freedom and multiscale dynamics in spin glasses. PMID- 9965594 TI - Particle correlations in the generalized Thomas-Fermi approach. PMID- 9965593 TI - Integral equation theory of polydisperse colloidal suspensions using orthogonal polynomial expansions. PMID- 9965595 TI - Symmetries of the Fokker-Planck equation and the Fisher-Frieden arrow of time. PMID- 9965596 TI - Survival probability in the presence of a dynamic trap. PMID- 9965597 TI - Two-dimensional acoustic turbulence. PMID- 9965598 TI - Anomalous scaling of a triple correlation function of a randomly advected passive scalar. PMID- 9965599 TI - Dielectrophoresis of a deformable fluid particle in a nonuniform electric field. PMID- 9965600 TI - Quadrupolar interaction in nematic liquid crystals. PMID- 9965601 TI - L beta '-->Lc' phase transition in phosphatidylcholine lipid bilayers: A disorder order transition in two dimensions. PMID- 9965602 TI - Non-Landau critical behavior of heat capacity at the smectic-A-smectic-C alpha * transition of the antiferroelectric liquid crystal methylheptyloxycarbonylphenyl octyloxycarbonylbiphenyl carboxylate. PMID- 9965604 TI - Origin of normal stress differences in rapid granular flows. PMID- 9965603 TI - Local reactivity limited aggregation. PMID- 9965606 TI - Low-frequency hydromagnetic modes of a uniformly magnetized liquid star. PMID- 9965605 TI - Stochastic gating in diffusion-influenced ligand binding to proteins: Gated protein versus gated ligands. PMID- 9965607 TI - Theory of magnetic field generation. PMID- 9965608 TI - Measurements of laser-speckle-induced perturbations in laser-driven foils. PMID- 9965609 TI - Synchronization of a chaotic laser pulsation with its prerecorded history. PMID- 9965610 TI - Comment on "Modeling of metal electrodeposits: Analytical solutions" PMID- 9965611 TI - Erratum: Transition operators in electromagnetic-wave diffraction theory. II. Applications to optics PMID- 9965612 TI - Erratum: Spatial Doppler anomaly in an excitable medium PMID- 9965613 TI - Fractal dimension of backbone of Eden trees. PMID- 9965614 TI - Relaxation in interacting arrays of oscillators. PMID- 9965616 TI - Stochastic resonance in a spatially extended system. PMID- 9965615 TI - Crossover from directed percolation to compact directed percolation. PMID- 9965617 TI - Scaling for random walks on Eden trees. PMID- 9965619 TI - Dynamics of the dissipative two-state system under ac modulation of bias and coupling energy. PMID- 9965618 TI - Tool to recover scalar time-delay systems from experimental time series. PMID- 9965620 TI - Critical dynamics of the contact process with quenched disorder. PMID- 9965621 TI - Synchronization waves in arrays of driven chaotic systems. PMID- 9965622 TI - Statistical uncertainty in the analysis of structure functions in turbulence. PMID- 9965623 TI - Experimental observation of dynamic mode switching in interfacial-tension-driven convection near a codimension-two point. PMID- 9965624 TI - Dynamical properties of multiarmed global spirals in Rayleigh-Benard convection. PMID- 9965625 TI - Scattering rates versus moments: Alternative Grad equations. PMID- 9965626 TI - Optical properties of antiferroelectric liquid crystals in free-standing films. PMID- 9965627 TI - Dynamics of the formation of an aureole in the bursting of soap films. PMID- 9965629 TI - Soliton stability in optical transmission lines using semiconductor amplifiers and fast saturable absorbers. PMID- 9965628 TI - Experimental observation of high-brightness microbunching in a photocathode rf electron gun. PMID- 9965630 TI - Coarsening dynamics of a one-dimensional driven Cahn-Hilliard system. PMID- 9965631 TI - Experimental observation of perturbation-induced intermittency in the dynamics of a loss-modulated CO2 laser. PMID- 9965632 TI - Enhancing chaos in chaotic maps and flows. PMID- 9965633 TI - Calogero-Sutherland model with twisted boundary condition. PMID- 9965634 TI - Percolation in random-Sierpin-acuteski carpets: A real space renormalization group approach. PMID- 9965635 TI - Multifractal features of random walks and localized vibrational excitations on random fractals: Dependence on the averaging procedure. PMID- 9965636 TI - Spreading of damage in the ballistic deposition and larger curvature models. PMID- 9965637 TI - Another possible description of fluctuations. PMID- 9965638 TI - Nonlinear dynamics of the magnetization in an anisotropic ferromagnet with a magnetic field. PMID- 9965639 TI - Medium-range interactions and crossover to classical critical behavior. PMID- 9965640 TI - Beyond the mean field approximation for spin glasses. PMID- 9965641 TI - Topological singularities of domains in globally constrained bistable reaction diffusion systems. PMID- 9965642 TI - Second moment for cooperative diffusion in one-dimensional hard-particle lattice gases. PMID- 9965643 TI - Energy diffusion due to nonlinear perturbation on linear Hamiltonians. PMID- 9965645 TI - Transforming signals with chaotic synchronization. PMID- 9965644 TI - Complexity in Hamiltonian-driven dissipative chaotic dynamical systems. PMID- 9965646 TI - Multifractality in the stochastic Burgers equation. PMID- 9965647 TI - Hamiltonian systems with many degrees of freedom: Asymmetric motion and intensity of motion in phase space. PMID- 9965648 TI - Lyapunov exponents for classical-quantum mixed-mode dynamics. PMID- 9965649 TI - Noise-activated diffusion in the egg-carton potential. PMID- 9965650 TI - Dynamical critical exponent of a nonequilibrium Ising model. PMID- 9965651 TI - Quantum particle transfer in a system with a discontinuous modulation of the intersite coupling. PMID- 9965652 TI - Heat transport in a boson system: An information-theoretical approach. PMID- 9965653 TI - Field dependence of Lyapunov exponents for nonequilibrium systems. PMID- 9965654 TI - Far from equilibrium nonconserved growth under a surface diffusion bias. PMID- 9965655 TI - Dynamical approach to Levy processes. PMID- 9965656 TI - Comparison of methods for the calculation of superparamagnetic relaxation times. PMID- 9965657 TI - Kinetics of an order-disorder phase transition with topological defects. PMID- 9965658 TI - Crisis in the periodic Lorentz gas. PMID- 9965659 TI - Periodic forcing of spiral waves in excitable media. PMID- 9965660 TI - Observer based synchronization of chaotic systems. PMID- 9965662 TI - Fractal dimensions of chaotic saddles of dynamical systems. PMID- 9965661 TI - Characterization of Landau-Zener transitions in systems with complex spectra. PMID- 9965663 TI - Experimental control of high-dimensional chaos: The driven double pendulum. PMID- 9965664 TI - Collision properties of one-dimensional granular particles with internal degrees of freedom. PMID- 9965665 TI - Simple nonequilibrium extension of the Ising model. PMID- 9965666 TI - Exponents appearing in heterogeneous reaction-diffusion models in one dimension. PMID- 9965667 TI - Scenarios of domain pattern formation in a reaction-diffusion system. PMID- 9965669 TI - Fluctuation effects on chemical wave fronts. PMID- 9965668 TI - Automated adaptive recursive control of unstable orbits in high-dimensional chaotic systems. PMID- 9965670 TI - Instantons and intermittency. PMID- 9965672 TI - Turbulent spots in plane Couette flow. PMID- 9965671 TI - Instantons in the Burgers equation. PMID- 9965673 TI - Thermodynamics of ideal gases in quasistatic electromagnetic fields. PMID- 9965674 TI - Symmetry breaking and period doubling on a torus in the VLF regime in Taylor Couette flow. PMID- 9965675 TI - Stability of pole solutions for planar propagating flames. PMID- 9965676 TI - Short-wavelength instability in systems with slow long-wavelength dynamics. PMID- 9965677 TI - Anomalous scaling in random shell models for passive scalars. PMID- 9965679 TI - Instability of converging shock waves and sonoluminescence. PMID- 9965678 TI - Towards a theory of self-organization phenomena in bubble-liquid mixtures. PMID- 9965680 TI - Triply periodic surfaces and multiply continuous structures from the Landau model of microemulsions. PMID- 9965681 TI - Diffusion in spatially and temporarily inhomogeneous media. PMID- 9965682 TI - Rotating spirals in a Faraday experiment. PMID- 9965683 TI - Lattice Boltzmann simulations of liquid-gas and binary fluid systems. PMID- 9965684 TI - Temporal modulation of traveling waves in the flow between rotating cylinders with broken azimuthal symmetry. PMID- 9965685 TI - Fluid-induced particle-size segregation in sheared granular assemblies. PMID- 9965687 TI - Topological correlations in Benard-Marangoni convective structures. PMID- 9965686 TI - Second-order continuum traffic flow model. PMID- 9965688 TI - Condensate turbulence in two dimensions. PMID- 9965689 TI - Limitations of random multipliers in describing turbulent energy dissipation. PMID- 9965691 TI - Velocity fluctuations in forced Burgers turbulence. PMID- 9965690 TI - Unidirectionally coupled map lattice as a model for open flow systems. PMID- 9965692 TI - Dynamics of vortex lines in turbulent flows. PMID- 9965693 TI - Computer simulations of domain growth and phase separation in two-dimensional binary immiscible fluids using dissipative particle dynamics. PMID- 9965694 TI - Numerical heat conductivity in smooth particle applied mechanics. PMID- 9965696 TI - Eckhaus-Benjamin-Feir instability in systems with temporal modulation. PMID- 9965695 TI - Vortex flow pattern selection and temporal-spatial structures of transverse and mixed vortex rolls in mixed convection of air in a horizontal flat duct. PMID- 9965697 TI - Broadband dielectric measurements on the (R)-1-methylheptyl-6-(4' decyloxybenzoyloxy)-2-naphthalene carboxylate antiferroelectric liquid crystal. PMID- 9965698 TI - Molecular dynamics of model liquid crystals composed of semiflexible molecules. PMID- 9965699 TI - Chiral nematic liquid crystals in cylindrical cavities. PMID- 9965700 TI - Director structure around a colloid particle suspended in a nematic liquid crystal. PMID- 9965702 TI - Structure of the hexagonal phase of the sodium dodecyl sulfate and water system. PMID- 9965701 TI - Friction drag on a particle moving in a nematic liquid crystal. PMID- 9965703 TI - Anomalous anchoring effect of nanopolyimide Langmuir-Blodgett films in a twisted nematic liquid-crystal cell. PMID- 9965704 TI - Theory of translational diffusion in the nematic phase. PMID- 9965705 TI - Electrohydrodynamic convection under a nematic-isotropic interface. PMID- 9965707 TI - Annihilation of point defects in nematic liquid crystals. PMID- 9965706 TI - Thickness-dependent phase transition in thin nematic films. PMID- 9965708 TI - Angular dependence of light transmittance in polymer dispersed liquid crystals. PMID- 9965709 TI - Critical and multicritical fluctuations of nematic liquid crystals. PMID- 9965711 TI - Isotropic-nematic transition of surface embedded polymers and the associated tubulization transition of the embedding surface. PMID- 9965710 TI - Conformations of randomly linked polymers. PMID- 9965712 TI - NMR flow velocity mapping in random percolation model objects: Evidence for a power-law dependence of the volume-averaged velocity on the probe-volume radius. PMID- 9965713 TI - Dynamics of crystallization in hard-sphere suspensions. PMID- 9965714 TI - Kinetic crossover of rough surface growth in a colloidal system. PMID- 9965715 TI - Double-exponential relaxation near the critical point of an ionic micellar system. PMID- 9965716 TI - Shape of the tip and the formation of sidebranches of xenon dendrites. PMID- 9965717 TI - Anomalous effects in the temperature dependence of depolarized Rayleigh spectra of benzene and quinoline. PMID- 9965718 TI - Clustering properties of d-dimensional overlapping spheres. PMID- 9965720 TI - Amplitude of the anomaly in the mass density near a liquid-liquid critical point. PMID- 9965719 TI - Dynamics of heteropolymers in dilute solution: Effective equation of motion and relaxation spectrum. PMID- 9965721 TI - Tagged-particle motion in viscous glycerol: Diffusion-relaxation crossover. PMID- 9965722 TI - Elastic properties of randomly cross-linked polymers. PMID- 9965723 TI - Dielectric investigations of the dynamic glass transition in nanopores. PMID- 9965725 TI - Simulation of the formation of nonequilibrium structures in magnetorheological fluids subject to an external magnetic field. PMID- 9965724 TI - Structure and thermodynamics of binary liquid mixtures: Universality of the bridge functional. PMID- 9965726 TI - Kosterlitz-Thouless transitions on a fluctuating surface of genus zero. PMID- 9965727 TI - Mechanism of the cooperative relaxation in microemulsions near the percolation threshold. PMID- 9965728 TI - Effects of interparticle electric interactions on dielectrophoresis in colloidal suspensions. PMID- 9965730 TI - Predicting disorder-order phase transitions in polymeric micelles. PMID- 9965729 TI - Deformation of small compressed droplets. PMID- 9965731 TI - Concentration dependence of structural and dynamical quantities in colloidal aggregation: Computer simulations. PMID- 9965732 TI - Stability of cylindrical vesicles under axial tension. PMID- 9965733 TI - Structure of complex-periodic and chaotic media with spiral waves. PMID- 9965735 TI - Computer simulation of the rheology of grafted chains under shear. II. Depletion of chains at the wall. PMID- 9965734 TI - Statistical properties and shell analysis in random cellular structures. PMID- 9965737 TI - Inelastic collapse of rotating spheres. PMID- 9965736 TI - Fluctuation dynamics of a single magnetic chain. PMID- 9965738 TI - Frequency analysis with Hopfield encoding neurons. PMID- 9965740 TI - Microtubule dynamics: Caps, catastrophes, and coupled hydrolysis. PMID- 9965739 TI - Partial synchronization in populations of pulse-coupled oscillators. PMID- 9965741 TI - Self-similar sequences and universal scaling of dynamical entropies. PMID- 9965742 TI - Clustering of independently diffusing individuals by birth and death processes. PMID- 9965743 TI - Paramagnetic unlearning in neural network models. PMID- 9965744 TI - Aperiodic stochastic resonance. PMID- 9965745 TI - Statistical properties of stochastic nonlinear dynamical models of single spiking neurons and neural networks. PMID- 9965746 TI - Imaginary-emission method for modeling disturbances of all magnetoplasma species: Reflecting and absorbing objects in motion through a rarefied plasma at different angles to the ambient magnetic field. PMID- 9965747 TI - Linear theory of plasma C-caronerenkov masers. PMID- 9965748 TI - Analysis of the passage of a laser pulse through a hole. PMID- 9965750 TI - Suppression of the edge interchange instability in a straight tokamak. PMID- 9965749 TI - Absorption experiments on x-ray-heated mid-Z constrained samples. PMID- 9965751 TI - Three-dimensional structure in a crystallized dusty plasma. PMID- 9965752 TI - Resonant charge exchange and the transport of ions at high electric-field to gas density ratios (E/N) in argon, neon, and helium. PMID- 9965753 TI - Energy measurement of relativistic electron beams by laser Compton scattering. PMID- 9965754 TI - Symplectic scaling of transfer maps including fringe fields. PMID- 9965755 TI - Adiabatic matching of a nonuniform intense charged-particle beam into the focusing channel. PMID- 9965756 TI - Dynamics of a relativistic charged particle in a constant homogeneous magnetic field and a transverse homogeneous rotating electric field. PMID- 9965757 TI - Anomalous pulse delay in microwave propagation: A case of superluminal behavior. PMID- 9965758 TI - Path-integral analysis of scalar wave propagation in multiple-scattering random media. PMID- 9965759 TI - Existence and stability chart for the ac-driven, damped nonlinear Schrodinger solitons. PMID- 9965760 TI - Experimental study of granular convection. PMID- 9965761 TI - Nonlinear spectral characterization of discrete data. PMID- 9965762 TI - Perturbation theory for coupled nonlinear Schrodinger equations. PMID- 9965763 TI - Electrodynamics in complex systems: Application to near-field probing of optical microresonators. PMID- 9965765 TI - Stability of normal mode oscillations of one-dimensional anharmonic lattices. PMID- 9965764 TI - Self-bending photorefractive solitons. PMID- 9965766 TI - Morphological instabilities of dynamic fractures in brittle solids. PMID- 9965767 TI - Propagation of an electromagnetic pulse through a waveguide with a barrier: A time domain solution within classical electrodynamics. PMID- 9965768 TI - Solitonlike solutions of the generalized discrete nonlinear Schrodinger equation. PMID- 9965770 TI - Constraint operator solution to quantum billiard problems. PMID- 9965769 TI - Interactions between polarized soliton pulses in optical fibers: Exact solutions. PMID- 9965771 TI - Microcanonical evidence of a first-order phase transition in the four-dimensional U(1) lattice gauge theory. PMID- 9965772 TI - Driven-dissipative Euler's equations for a rigid body: A chaotic system relevant to fluid dynamics. PMID- 9965773 TI - Path integral Monte Carlo study of the internal quantum state dynamics of a generic model fluid. PMID- 9965774 TI - Metastable periodic Freedericksz transition in nematic liquid crystals. PMID- 9965775 TI - Nucleation and growth of anisotropic grain in block copolymers near order disorder transition. PMID- 9965777 TI - Effects of hydrostatic pressure on the monoolein-water system: An estimate of the energy function of the inverted Ia3d cubic phase. PMID- 9965776 TI - Functional Langevin models for the mesoscopic dynamics of surfactant aggregation in solution. PMID- 9965778 TI - Ion acoustic solitons in a weakly relativistic magnetized warm plasma. PMID- 9965780 TI - Electrical conductivity of tungsten near its critical point. PMID- 9965779 TI - High temperature of laser-compressed shells measured with Kr34+ and Kr35+ x-ray lines. PMID- 9965782 TI - 4/3 problem in classical electrodynamics. PMID- 9965781 TI - Dielectric response of particle beams to periodic focusing. PMID- 9965783 TI - Monte Carlo simulations in generalized ensemble: Multicanonical algorithm versus simulated tempering. PMID- 9965784 TI - Comment on "Phenomenological approach to the problem of the K13 surfacelike elastic term in the free energy of a nematic liquid crystal" PMID- 9965785 TI - Comment on "Generalized Kelvin equation and the water content of a cloud" PMID- 9965786 TI - Comment on "Fitting of viscosity: Distinguishing the temperature dependences predicted by various models of supercooled liquids" PMID- 9965787 TI - Reply to "Comment on 'Fitting of viscosity: Distinguishing the temperature dependences predicted by various models of supercooled liquids' " PMID- 9965788 TI - Gaussian unitary ensemble eigenvalues and Riemann zeta function zeros: A nonlinear equation for a new statistic. PMID- 9965789 TI - Topological entropy of autonomous flows. PMID- 9965790 TI - Effective transfer rates for a dissipative two-level system driven by regular and stochastic fields. PMID- 9965791 TI - Self-organized criticality in a two-dimensional rotating drum model. PMID- 9965792 TI - Weak and strong synchronization of chaos. PMID- 9965793 TI - Self-organized criticality in a rice-pile model. PMID- 9965794 TI - Products of random matrices and investment strategies. PMID- 9965796 TI - Generation and structure of Rossby vortices in rotating fluids. PMID- 9965795 TI - Fusion rules and conditional statistics in turbulent advection. PMID- 9965797 TI - Heat transport in a liquid layer locally heated on its free surface. PMID- 9965798 TI - Nonlinear saturation of the turbulent alpha effect. PMID- 9965799 TI - Models of non-Newtonian Hele-Shaw flow. PMID- 9965801 TI - Quasi-long-range order in columnar liquid crystals. PMID- 9965800 TI - Azimuthal anchoring transition on nematic liquid crystals on self-assembled monolayers formed from odd and even alkanethiols. PMID- 9965802 TI - Triadic Hopf-static structures in two-dimensional optical pattern formation. PMID- 9965804 TI - Longitudinal radiation excitation in an electron storage ring. PMID- 9965803 TI - Controlled instability and multiscaling in models of epitaxial growth. PMID- 9965806 TI - Quasistatic calculation of linear response for crack propagation. PMID- 9965805 TI - Swirling granular matter: From rotation to reptation. PMID- 9965807 TI - Exponential distributions in a mechanical model for earthquakes. PMID- 9965808 TI - Dynamics of a system consisting of a van der Pol oscillator coupled to a Duffing oscillator. PMID- 9965809 TI - Growth equations for the Wolf-Villain and Das Sarma-Tamborenea models of molecular-beam epitaxy. PMID- 9965811 TI - Antiresonance and localization in quantum dynamics. PMID- 9965810 TI - Effects of bias on the kinetics of A+B-->C with initially separated reactants. PMID- 9965812 TI - Kinetics of a Verhulst-type system with nonlinearly coupled noise. PMID- 9965813 TI - Riemannian theory of Hamiltonian chaos and Lyapunov exponents. PMID- 9965815 TI - Theory of continuum percolation. I. General formalism. PMID- 9965814 TI - Properties of the class of power-logistic maps. PMID- 9965816 TI - Theory of continuum percolation. II. Mean field theory. PMID- 9965818 TI - Critical behavior in a quasifractal Ising model. PMID- 9965817 TI - Sheet structure in global bifurcations of a driven R-L-diode circuit. PMID- 9965819 TI - Computer investigation of long-range correlations and local order in random packings of spheres. PMID- 9965820 TI - Noise-induced transitions in coupled oscillator systems with a pinning force. PMID- 9965821 TI - Model of correlated evolution. PMID- 9965822 TI - Distribution function properties and the fundamental diagram in kinetic traffic flow theory. PMID- 9965823 TI - Meandering instability of a spiral interface in the free boundary limit. PMID- 9965825 TI - Spontaneous formation of concentric waves in a two-component reaction-diffusion system. PMID- 9965824 TI - Scaling behavior of transition to chaos in quasiperiodically driven dynamical systems. PMID- 9965826 TI - Fluctuations and the many-body Lyapunov exponent. PMID- 9965827 TI - Hidden order in the frequency noise of an electronic oscillator. PMID- 9965828 TI - Stability of the one-dimensional kink solution to a general Cahn-Hilliard equation. PMID- 9965830 TI - Fractalization of a torus as a strange nonchaotic attractor. PMID- 9965829 TI - Temporal correlations in a one-dimensional sandpile model. PMID- 9965831 TI - Nucleation model for multiparticle reactions with finite reaction rates in one dimension. PMID- 9965832 TI - Effect of reactant spatial distribution in the A+B-->0 reaction kinetics in one dimension with Coulomb interaction. PMID- 9965834 TI - Dynamic scaling of ion-sputtered rotating surfaces. PMID- 9965833 TI - Reaction-diffusion master equation: A comparison with microscopic simulations. PMID- 9965835 TI - Geometrical resonance in a driven symmetric bistable system subjected to strong or to weak damping. PMID- 9965836 TI - Activated rate processes in a double well coupled to a slow harmonic mode: Finite barrier effects. PMID- 9965837 TI - Complex-temperature singularities in Potts models on the square lattice. PMID- 9965838 TI - Spatial organization in cyclic Lotka-Volterra systems. PMID- 9965839 TI - Autoregressive self-tuning feedback control of the Henon map. PMID- 9965840 TI - Topological dependence of universal correlations in multiparameter Hamiltonians. PMID- 9965841 TI - Chaotic scattering through potentials with rainbow singularities. PMID- 9965842 TI - Avalanches, scaling, and coherent noise. PMID- 9965844 TI - Application of a new renormalization group to the equation of state of a hard sphere fluid. PMID- 9965843 TI - Diffusion- and drift-controlled reactions in two and three dimensions. PMID- 9965845 TI - Synchronization-based parameter estimation from time series. PMID- 9965846 TI - Experiments in a rotating Hele-Shaw cell. PMID- 9965847 TI - Towards a nonperturbative theory of hydrodynamic turbulence: Fusion rules, exact bridge relations, and anomalous viscous scaling functions. PMID- 9965848 TI - Microscale theory of surface tension. PMID- 9965849 TI - Refraction and reflection of a nonrelativistic wave when the interface and the media are moving. PMID- 9965850 TI - Theory of acoustic radiation pressure for actual fluids. PMID- 9965851 TI - Dynamics of neopentane in dense argon gases. PMID- 9965852 TI - Stochastic Benjamin-Ono equation and its application to the dynamics of nonlinear random waves. PMID- 9965854 TI - Supercooled water and the kinetic glass transition. PMID- 9965853 TI - Improved lattice Boltzmann model for incompressible two-dimensional steady flows. PMID- 9965855 TI - Noise-sustained structures in coupled complex Ginzburg-Landau equations for a convectively unstable system. PMID- 9965856 TI - Mean field equilibria of single coherent vortices. PMID- 9965857 TI - Conditional statistics in scalar turbulence: Theory versus experiment. PMID- 9965859 TI - Structure of the Ne-Xe mixture near the 26-MPa demixing curve at T=275 K. PMID- 9965858 TI - Morphological instability of the solid-liquid interface and the supersaturation gradient in crystal growth from a high-temperature solution. PMID- 9965860 TI - Molecular origin of ferroelectricity in induced smectic-C* liquid crystalline phases. PMID- 9965862 TI - Subharmonics arising from the application of an electric field across a smectic-C liquid crystal. PMID- 9965861 TI - Brillouin study of acoustic modes in isotropic, smectic-A, and smectic-C* phases in a ferroelectric liquid crystal. PMID- 9965863 TI - Onset of electroconvection in nematic liquid crystals with parallel magnetic field. PMID- 9965864 TI - Demixing versus ordering in hard-rod mixtures. PMID- 9965865 TI - Disclination asymmetry in two-dimensional nematic liquid crystals with unequal Frank constants. PMID- 9965866 TI - Critical behavior of dielectric permittivity in the isotropic phase of nematogens. PMID- 9965867 TI - Simple and coupled processes of reorientational relaxation in the isotropic phase of p-n-hexyl p'-cyanobiphenyl. PMID- 9965868 TI - Nonlinear dielectric relaxation and dynamic Kerr effect in a strong dc electric field suddenly switched on: Exact solutions for the three-dimensional rotational diffusion model. PMID- 9965869 TI - Nonisothermal eutectic crystallization. PMID- 9965871 TI - Patterns in the variable Hele-Shaw cell for different viscosity ratios: Similarity to river network geometry. PMID- 9965870 TI - Origin of stick-slip motion in a driven two-wave potential. PMID- 9965872 TI - Depletion interactions in colloid-polymer mixtures. PMID- 9965873 TI - Fractal scaling behavior of water flow patterns on inhomogeneous surfaces. PMID- 9965874 TI - Neutral polyampholyte in an ionic solution. PMID- 9965875 TI - Measurement of the Gaussian curvature of the surfactant film in an isometric bicontinuous one-phase microemulsion. PMID- 9965876 TI - Phase separation in two-dimensional binary fluids of different-sized molecules: A molecular-dynamics study. PMID- 9965877 TI - Biaxiality ordering of molecular orientation in a monolayer at the liquid-air interface. PMID- 9965878 TI - Dynamic light scattering studies on the sol-gel transition of a suspension of anisotropic colloidal particles. PMID- 9965879 TI - Deformation of fluid interfaces under double-layer forces stabilizes bubble dispersions. PMID- 9965880 TI - Monte Carlo calculations of phase diagrams for a fluid confined in a disordered porous material. PMID- 9965882 TI - Brownian motion of interacting nonspherical tracer particles: General theory. PMID- 9965881 TI - Ellipsoid contact potential: Theory and relation to overlap potentials. PMID- 9965884 TI - Concentration dependence of the sol-gel transition point and the network formation of polymer gels. PMID- 9965883 TI - Rotational diffusion of nonspherical Brownian particles in a suspension of spheres. PMID- 9965885 TI - Analysis of dielectric relaxation phenomena with molecular orientational ordering in monolayers at the liquid-air interface. PMID- 9965886 TI - Inhomogeneity in gelation and nonuniversality of sol-to-gel transitions studied by a computer simulation model. PMID- 9965887 TI - Flory-type theory of a knotted ring polymer. PMID- 9965888 TI - Symmetry-breaking density profiles in confined liquids. PMID- 9965889 TI - Phase transition, equation of state, and limiting shear viscosities of hard sphere dispersions. PMID- 9965890 TI - Order-disorder transitions in polymer-surfactant systems. PMID- 9965892 TI - Time-frequency analysis of electroencephalogram series. II. Gabor and wavelet transforms. PMID- 9965891 TI - Nonlinear response of layer growth dynamics in the mixed kinetics-bulk-transport regime. PMID- 9965893 TI - Compressive deformation of a single microcapsule. PMID- 9965895 TI - Barriers against DNA-loop formation in a porous matrix. PMID- 9965894 TI - Noise-induced transitions in human postural sway. PMID- 9965896 TI - Tube leakage during electrophoresis retards reptating DNA in unmodified and hydroxyethylated agarose gels. PMID- 9965897 TI - Detecting dynamical interdependence and generalized synchrony through mutual prediction in a neural ensemble. PMID- 9965898 TI - Fluctuation-induced interactions between rods on a membrane. PMID- 9965899 TI - Simulations of heating and electron energy distributions in optical field ionized plasmas. PMID- 9965900 TI - Shift of the Na PMID- 9965902 TI - Nonlinear Alfven waves in magnetized plasmas with heavy impurities or dust. PMID- 9965901 TI - Comparison of Monte Carlo simulations and nonlocal calculations of the electron distribution function in a positive column plasma. PMID- 9965903 TI - Characterization of laser plasmas for interaction studies: Progress in time resolved density mapping. PMID- 9965905 TI - Free-electron laser without inversion via transverse momentum discrimination. PMID- 9965904 TI - Theory and simulation of transverse supermode evolution in a free-electron laser oscillator. PMID- 9965907 TI - Coherent backscattering from anisotropic scatterers. PMID- 9965906 TI - Stability and halo formation of a breathing axisymmetric uniform-density beam. PMID- 9965908 TI - Rayleigh methods applied to electromagnetic scattering from gratings in general homogeneous media. PMID- 9965909 TI - Direct approach to the study of soliton perturbations. PMID- 9965910 TI - Nose-Andersen dynamics of partially rigid molecules: Coupling all degrees of freedom to heat and pressure baths. PMID- 9965911 TI - Importance of creeping waves in Schwinger variational-principle calculations of backscattering from cylinders with Neumann's boundary condition. PMID- 9965912 TI - Collision-induced friction in the motion of a single particle on a bumpy inclined line. PMID- 9965913 TI - Sound propagation in impure granular columns. PMID- 9965915 TI - Stress waves in composite materials. PMID- 9965914 TI - Temporal behavior of bidimensional photorefractive bright spatial solitons. PMID- 9965917 TI - Multiensemble sampling: An alternative efficient Monte Carlo technique. PMID- 9965916 TI - Random-lattice models and simulation algorithms for the phase equilibria in two dimensional condensed systems of particles with coupled internal and translational degrees of freedom. PMID- 9965918 TI - Heat flow studies for large temperature gradients by molecular dynamics simulation. PMID- 9965920 TI - Number of distinct sites visited on a percolation cluster: Characterization of fluctuations. PMID- 9965919 TI - Reentrant transition induced by multiplicative noise in the time-dependent Ginzburg-Landau model. PMID- 9965922 TI - Stochastic resonance in a dipole. PMID- 9965921 TI - Nonlinear differential delay equations using the Poincare section technique. PMID- 9965923 TI - Nonequilibrium corrections in the pressure tensor due to an energy flux. PMID- 9965925 TI - Switching between orbits in a periodic window. PMID- 9965924 TI - Nonsimultaneity effects in globally coupled maps. PMID- 9965926 TI - External noise in periodically forced Rayleigh-Benard convection. PMID- 9965927 TI - Multifractal structure and intermittency of laser-generated turbulence in nematic liquid crystals. PMID- 9965928 TI - Periodicity in nematic liquid crystal walls. PMID- 9965929 TI - Ostwald ripening on the wall of a semi-infinite system. PMID- 9965930 TI - Polymer brush under strong shear. PMID- 9965932 TI - Absorbing boundary conditions for inertial random processes. PMID- 9965931 TI - Universal behavior of the structure of assemblies of particles irreversibly deposited on solid surfaces. PMID- 9965933 TI - Comment on "Depolarized light scattering study of molten zinc chloride" PMID- 9965934 TI - Reply to "Comment on 'Depolarized light scattering study of molten zinc chloride"' PMID- 9965935 TI - Erratum: Estimating functions of probability distributions from a finite set of samples PMID- 9965936 TI - Erratum: Influence of electron collisions on the resonance cone phenomenon in a cold magnetized plasma PMID- 9965937 TI - Low-temperature phase of the three-state antiferromagnetic Potts model on the simple-cubic lattice. PMID- 9965938 TI - Stabilization of the less stable orbit by a tiny near-resonance periodic signal. PMID- 9965939 TI - Dimensional crossovers and anomalous scaling of single and reacting random walkers in baguettelike lattices: Monte Carlo simulations of the number of distinct sites visited and of bimolecular A+A and A+B reactions. PMID- 9965940 TI - Finite size effects in simulations of glass dynamics. PMID- 9965941 TI - Large-scale flow properties of turbulent thermal convection. PMID- 9965942 TI - Simulation of the binary hard-sphere crystal/melt interface. PMID- 9965943 TI - Stringlike patterns in critical polymer mixtures under steady shear flow. PMID- 9965944 TI - Self-diffusion near the percolation threshold in reverse microemulsions. PMID- 9965946 TI - Frequency-modulated autowaves in excitable media. PMID- 9965945 TI - Monte Carlo study of excluded volume effects in wormlike micelles and semiflexible polymers. PMID- 9965947 TI - Search for neutron emission from deuterium-loaded palladium. PMID- 9965949 TI - Lambda N- Sigma N coupling in Lambda 3H. PMID- 9965950 TI - Pseudoscalar pi N coupling and relativistic proton-nucleus scattering. PMID- 9965948 TI - Coupling between the beta and gamma vibration in tungsten nuclei. PMID- 9965951 TI - Chiral repulsion in the pion-nucleus optical potential. PMID- 9965952 TI - Inelastic lepton-deuteron scattering: Possible coherent effects. PMID- 9965953 TI - Electron scattering sum rules in polarized nuclei. PMID- 9965955 TI - Evaluation of semiclassical trajectory contributions to the cross section. PMID- 9965954 TI - 7Li(p,n)7Be and 12C(p,n)12N reactions at 200, 300, and 400 MeV. PMID- 9965956 TI - Production of 13N radioactive nuclei from 13C(p,n) or 16O(p, alpha ) reactions. PMID- 9965958 TI - Three-body effects in the 7Li (d, alpha alpha n) reaction. PMID- 9965957 TI - 15N(d PMID- 9965959 TI - Deexcitation gamma rays following the photodisintegration of 17O. PMID- 9965960 TI - Production of helium (Z=2) projectile fragments in 16O-emulsion interactions from E/A=2 to 200 GeV. PMID- 9965961 TI - Location of major alpha strength in 13C at 10.75 MeV. PMID- 9965962 TI - Magnetic moments of low-lying states in 103Rh, 111,113Cd, and 123,125Te. PMID- 9965963 TI - Identification of projectile sequential decay and incomplete fusion in the 16O+28Si, 16O+27Al, and 10B+27Al systems at 4-5 MeV/nucleon. PMID- 9965965 TI - Statistical model of nuclear multifragmentation. PMID- 9965964 TI - Fusion and binary reactions in the collision of 32S on 26Mg at Elab PMID- 9965966 TI - Production of the H dibaryon in relativistic heavy-ion collisions. PMID- 9965967 TI - Coupled-channels calculations of elastic and inelastic scattering. PMID- 9965968 TI - Shape coexistence in 187Au. PMID- 9965969 TI - K+/-, p-bar, and Omega - production in relativistic heavy ion collisions. PMID- 9965971 TI - Nuclear thermometers for heavy-ion collisions. PMID- 9965970 TI - High-spin structures in 137Sm: Role of the beta -driving nu i13/2 intruder in deformation enhancement. PMID- 9965972 TI - Reaction mechanisms in 28Si+24Mg--> alpha +24Mg+24Mg and alpha +20Ne+28Si. PMID- 9965973 TI - Excitation function of the quasifree contribution in the 2H(7Li, alpha alpha )n reaction at E0=28-48 MeV. PMID- 9965974 TI - Complex fragments emitted in particle-stable states for the 32S+natAg reaction at E/A=22.3 MeV. PMID- 9965975 TI - Giant resonance strength distribution in 40Ca from inelastic scattering of 500 MeV protons. PMID- 9965976 TI - Three-body unitarity, the cloudy bag model, and the Roper resonance. PMID- 9965977 TI - Spin-flip cross sections for 13C(p PMID- 9965978 TI - Different continuum approaches to giant resonances in 208Pb with 400-MeV protons. PMID- 9965979 TI - Three-nucleon pion absorption in carbon. PMID- 9965980 TI - Inclusive ( pi +,p) and ( pi +,pp) cross sections for light nuclei in the resonance energy region. PMID- 9965981 TI - Relativistic motion of a Lambda particle in hypernuclei and phenomenological analysis of its binding energy. PMID- 9965982 TI - Nuclear response and hadron formation length in high-energy hadron-nucleus interactions. PMID- 9965983 TI - Polarization response functions and the (e PMID- 9965985 TI - Laser applications to fundamental weak interaction studies. PMID- 9965984 TI - Operator expansion method and the double beta decay of 48Ca. PMID- 9965986 TI - Two-loop corrections for nuclear matter in the Walecka model. PMID- 9965987 TI - Effective masses in relativistic approaches to the nucleon-nucleus mean field. PMID- 9965989 TI - Wave function of 14N. PMID- 9965988 TI - Binding of hydrogen and helium in silicon, the mass difference between 3H and 3He, and the mass of nu e. PMID- 9965990 TI - Two-quasiparticle states in the interacting boson approximation and the structure of even Pt isotopes. PMID- 9965992 TI - Finite nucleus Dirac mean field theory and random phase approximation using finite B splines. PMID- 9965991 TI - Shell-model calculations for the energy levels of the N=50 isotones with A=80-87. PMID- 9965993 TI - Collective modes in hot and dense matter. PMID- 9965995 TI - Half-life of 56Co. PMID- 9965994 TI - Coriolis coupling in the rotational bands of deformed odd-odd nuclei. PMID- 9965996 TI - Evidence for collective structure in 214Po. PMID- 9965997 TI - Spin excitations in light nuclei: Effect of projectile energy. PMID- 9965998 TI - Shape of 24Mg at zero and finite temperature. PMID- 9965999 TI - Exciton model analysis of neutron spectra from fusion and quasifusion of two heavy ions. PMID- 9966000 TI - (6Li,d) stripping into unbound states. PMID- 9966002 TI - Erratum: Broken SU(3) symmetry applied to rotational nuclei: Cylindrical intrinsic states in the interacting boson model PMID- 9966001 TI - Comment on "Feasibility of measurement of the electromagnetic polarizability of the bound nucleon" PMID- 9966003 TI - Gamow-Teller and spin-dipole strength in 90Zr(n,p) at 65 MeV. PMID- 9966004 TI - Formation of Lambda 4H hypernuclei from K- absorption at rest on light nuclei. PMID- 9966005 TI - Compound-hypernucleus interpretation of Lambda 4H formation probabilities in stopped-K- absorption. PMID- 9966006 TI - Double blocking in doubly odd deformed nuclei: The case of 178Re. PMID- 9966007 TI - Momentum dependence of the nuclear mean field. PMID- 9966008 TI - Fusion rates of squeezed and screened hydrogenic nuclei. PMID- 9966010 TI - p-4He scattering: Inversion of phase shifts at 64.9 MeV. PMID- 9966009 TI - High-momentum nucleons in finite nuclei and y scaling. PMID- 9966011 TI - 15N photoneutron cross section. PMID- 9966013 TI - Branching ratios for 3He( alpha, gamma )7Be and 3H( alpha, gamma )7Li. PMID- 9966014 TI - Low energy theorem and polarization effects in 2H( gamma,n)1H. PMID- 9966012 TI - K-matrix analysis of the 12C( alpha, gamma ) reaction at low energy. PMID- 9966015 TI - Preequilibrium model analysis of (p,n) reactions on nuclei in the Cr-Ni region. PMID- 9966016 TI - Low-lying structures in the Gamow-Teller strength functions for the double-beta decaying nuclei 76Ge, 82Se, 128Te, and 130Te. PMID- 9966017 TI - Proton stripping to 8- stretched states in 52Cr. PMID- 9966018 TI - Gamow-Teller strength deduced from charge exchange reactions on 54Fe at 300 MeV. PMID- 9966019 TI - 48Ca(d,n)49Sc reaction at 79 MeV. PMID- 9966020 TI - Reactions 54Fe(p, gamma )55Co and 54Fe(p,p' gamma )54Fe from 2.35 to 3.90 MeV. PMID- 9966021 TI - Neutron scattering in 189Os for nucleosynthesis rates of the odd-A Os isotopes and nucleochronology. PMID- 9966022 TI - Temperatures in heavy ion reactions: Simulation via quasiparticle dynamics. PMID- 9966023 TI - Quasiparticle nature of rotational bands in 185Pt. PMID- 9966024 TI - Rotational bands in doubly odd 128Cs. PMID- 9966026 TI - Transverse limited phase space model with Glauber geometry for high-energy nucleus-nucleus collisions. PMID- 9966025 TI - Angular momentum role in cross-section energy coherence of heavy-ion dissipative collisions. PMID- 9966027 TI - Inclusive production of K+ mesons in 2.1-GeV/nucleon nuclear collisions. PMID- 9966028 TI - Determination of the impact vector in intermediate energy heavy ion collisions. PMID- 9966029 TI - Possible dynamic effects in the particle decay of 59Cu compound nuclei. PMID- 9966030 TI - Influence of rotation-induced nuclear deformation on alpha -particle evaporation spectra. PMID- 9966031 TI - Structures in the excitation function of 24Mg(16O,20Ne)20Ne and a nonresonant description of these structures. PMID- 9966032 TI - Potential model calculation of energetic photon production from heavy ion collisions. PMID- 9966033 TI - Neutron emission from products of strongly damped reactions 58Ni+165Ho at 930 MeV. PMID- 9966034 TI - Spin-orbit force in time-dependent Hartree-Fock calculations of heavy-ion collisions. PMID- 9966035 TI - Unified calculation of photon and pion spectra in intermediate energy heavy ion reactions. PMID- 9966036 TI - Long-range correlation widths in light heavy-ion nuclear reactions. PMID- 9966037 TI - High-spin studies of 172,173Os: Complex alignment mechanism. PMID- 9966038 TI - Dissipative mechanisms in the 120 MeV 19F+64Ni reaction. PMID- 9966040 TI - Resonances in the 13C(13C, alpha )22Ne reaction for Ec.m.=10.3-13.4 MeV. PMID- 9966039 TI - Coupled-channel results for atomic excitations in intermediate-energy heavy-ion collisions. PMID- 9966041 TI - Spontaneous fission properties of 258Fm, 259Md, 260Md, 258No, and 260 PMID- 9966042 TI - Pion inelastic scattering to the low-lying broad 2+ in 20Ne. PMID- 9966043 TI - Final-state interactions and relativistic effects in the quasielastic (e,e') reaction. PMID- 9966045 TI - Proton-induced production of eta on nuclei. PMID- 9966044 TI - 12,13C(p PMID- 9966046 TI - Low energy pion-nucleus potentials from differential and integral data. PMID- 9966047 TI - Properties of the giant dipole resonance built on the isobaric analog state. PMID- 9966049 TI - Effects of nuclear forces on neutrino opacities in hot nuclear matter. PMID- 9966048 TI - Isospin asymmetries in pion scattering to isoscalar giant quadrupole states in Ni isotopes. PMID- 9966051 TI - Off-shell effects from meson exchange in the nuclear optical potential. PMID- 9966050 TI - Formation of deeply bound pi - states from hypernuclear decay. PMID- 9966052 TI - Tensor polarization of the elastic e-2H scattering and the scaling behavior of six-quark dynamics. PMID- 9966053 TI - Observable effects of poles and shadow poles in coupled-channel systems. PMID- 9966054 TI - Nucleon-nucleon potentials from Gel'fand-Levitan and Marchenko inversions. PMID- 9966055 TI - Level structure of the odd mass Pr isotopes: Levels of 143Pr84 populated in the beta decay of 143Ce. PMID- 9966057 TI - Generalization of the sum rule for double Gamow-Teller operators. PMID- 9966056 TI - Magnetic moment of the 21+ state in 98Sr. PMID- 9966059 TI - Adiabatic time-dependent Hartree-Fock theory in the generalized valley approximation. PMID- 9966058 TI - Energy of the superallowed positron decay of 10C. PMID- 9966060 TI - Tensor forces and the response functions of nuclear matter. PMID- 9966061 TI - Pair truncation for rotational nuclei: j=(17/2 model. PMID- 9966062 TI - Coupled-rearrangement-channel Gaussian-basis variational method for trinucleon bound states. PMID- 9966063 TI - Possible Bose-Fermi symmetries in the giant resonance fragmentation of deformed odd-even nuclei. PMID- 9966064 TI - Reliability of the finite temperature Hartree-Fock approximation. PMID- 9966065 TI - Seniority structure of the cranked shell model wave function and the pairing phase transition. PMID- 9966066 TI - Particle-vibration coupling in odd mass N=83 nuclei. PMID- 9966068 TI - Quadrupole collective models from the Hartree-Fock standpoint. PMID- 9966067 TI - Nuclear matter response function. PMID- 9966069 TI - Consistent three-nucleon forces in the nuclear many-body problem. PMID- 9966070 TI - Structure of odd-odd 74Ga from the decay of neutron-rich 74Zn. PMID- 9966071 TI - New rotational bands in 166Ho. PMID- 9966073 TI - Configurational quasidegeneracy and the liquid drop model. PMID- 9966072 TI - Broad component of the ( pi +,pp) angular correlation. PMID- 9966074 TI - Parton bremsstrahlung as a mechanism of energy deposition in high-energy hadron nucleus and nucleus-nucleus collisions. PMID- 9966075 TI - Charged pions from the isotopes 58,64Ni by 201 MeV protons. PMID- 9966077 TI - Quadrupole and octupole radiation from 16O near 39 MeV excitation. PMID- 9966076 TI - Comparison of two methods for calculating finite-temperature ring diagrams. PMID- 9966078 TI - Giant M1 resonance in 120Sn and the quenching of the nucleon spin g factors. PMID- 9966079 TI - Radiative muon capture on oxygen and the induced pseudoscalar coupling. PMID- 9966080 TI - Measurements of discrete nuclear reactions induced by a radioactive 8Li beam. PMID- 9966081 TI - Identification of the T=1, 6- stretched state in 40Ca by inelastic proton and deuteron scattering. PMID- 9966082 TI - Method for measurements of absolute analyzing powers in nuclear reactions. PMID- 9966083 TI - Comparison between the exact and the thermal description of the pairing interaction in 114Sn. PMID- 9966085 TI - Relations between polarized-proton-nucleus and unpolarized-transverse-electron nucleus scattering and applications. PMID- 9966084 TI - Subthreshold antiproton production in nucleus-nucleus collisions. PMID- 9966086 TI - Width of the level at Ex PMID- 9966087 TI - (p,p alpha ) cluster-knockout reaction on 9Be at 200 MeV. PMID- 9966088 TI - Resonances and time-delay in three-body scattering. PMID- 9966089 TI - Separable expansion for the two-body T matrix based on a nonsingular scattering equation. PMID- 9966090 TI - Quasielastic (e,e') sum rule saturation. PMID- 9966091 TI - Nuclear-structure dependence of the E1 strength located in the giant dipole resonance of heavy nuclei. PMID- 9966092 TI - Spectral structure of 245-445 keV electrons and positrons in positron-thorium scattering. PMID- 9966093 TI - Single nucleon removal in relativistic nuclear collisions. PMID- 9966095 TI - Velocity dependence of prompt, high-energy nucleon emission. PMID- 9966094 TI - High-energy gamma-ray production in the heavy-ion reaction 136Xe + Sn at E/A=89 and 124 MeV. PMID- 9966096 TI - Interacting gluon model for hadron-nucleus and nucleus-nucleus collisions in the central rapidity region. PMID- 9966097 TI - Spin of the 219Ra ground state. PMID- 9966098 TI - Inelastic scattering of 210 MeV 6Li ions from 12C, 28Si, and 58Ni: Test of unique 6Li potentials. PMID- 9966099 TI - Nonequilibrium fission and heavy residue production in the interaction of 12-16 MeV/nucleon 32S with 165Ho. PMID- 9966100 TI - Shape coexistence in 132Ba. PMID- 9966101 TI - Monte Carlo simulation of peripheral collisions in the 40Ar+27Al reaction at 44 MeV/nucleon using the nuclear random walk model. PMID- 9966102 TI - Nuclear molecular configurations in heavy ion collisions. PMID- 9966103 TI - Linear momentum transfer in the reaction of 64-269 MeV 3He with 238U. PMID- 9966104 TI - Special two-energy-two-angle approximation for bremsstrahlung. PMID- 9966105 TI - Microscopic s-wave optical potential for slow pions scattered by a nucleus. PMID- 9966107 TI - Optical potentials for alpha particles on Ca isotopes at 1.37 GeV. PMID- 9966106 TI - Spin-spin and tensor observables in the isovector nucleon-nucleon force. PMID- 9966108 TI - Electromagnetic interactions of extended nucleons. PMID- 9966109 TI - Reaction 3He( pi +,pp)p at T pi =350 and 500 MeV. PMID- 9966110 TI - y scaling and hard-core potentials. PMID- 9966111 TI - Atomic screening effects on electron-neutrino angular correlation and beta -decay asymmetry in allowed transitions. PMID- 9966113 TI - 4He binding energy calculation including full tensor-force effects. PMID- 9966112 TI - 123Cd level scheme. PMID- 9966114 TI - Relativistic Hartree calculations of odd-A nuclei. PMID- 9966116 TI - Comparisons of interacting-boson-fermion approximation and triaxial calculations for odd-mass N=80 nuclei. PMID- 9966115 TI - Electromagnetic form factors of odd-A rotational nuclei. PMID- 9966117 TI - Model analysis of the relationship between 3S1 scattering length and the root mean-square radius of the deuteron. PMID- 9966118 TI - Proton mean-free path in nuclear matter and in finite nuclei. PMID- 9966119 TI - Pions in the deuteron. PMID- 9966120 TI - 0(+),T=0(p,p')0(-),T=1 pion like excitations and nuclear response in the spin isospin channel. PMID- 9966121 TI - Effect of a second fermion pair on the structure of N=88 isotones. PMID- 9966122 TI - Coulomb sum rule of A=2, 3, and 4 nuclei. PMID- 9966123 TI - Electromagnetic and hadronic interaction form factors for the ground, ((3/2 (1/2)1 and ((3/2-(3/2)1 states in 13C and 13N. PMID- 9966124 TI - Nuclear level-density parameter in hot nuclei. PMID- 9966125 TI - Radiative capture of tensor and vector polarized deuterons by 3H at 400 keV. PMID- 9966126 TI - Solution of controversy over 1583-keV levels in 204Pb. PMID- 9966127 TI - Fission stability diagram of 240Pu. PMID- 9966128 TI - Method for computing coupled-channels Gamow-state energies. PMID- 9966129 TI - Hexadecapolar excitation in 100Ru. PMID- 9966131 TI - Possible existence of a low-energy octupole resonance in 208Pb. PMID- 9966130 TI - Evidence for reflection asymmetric shape in the nucleus 16151Pm90. PMID- 9966132 TI - Distorted wave impulse approximation calculations of 6Li(p,pd)4He reaction at 8 and 9 MeV. PMID- 9966133 TI - New comparisons of the coupled-channel model with elastic deuteron form factors. PMID- 9966134 TI - Anomalous nuclear enhancement in large transverse momentum hadron production. PMID- 9966136 TI - Cold nuclear fusion in metallic hydrogen and normal metals. PMID- 9966135 TI - Erratum: 2H( gamma,n) absolute cross section at 2754 keV PMID- 9966137 TI - Search for neutrons from deuterium-deuterium nuclear reactions in electrochemically charged palladium. PMID- 9966138 TI - Measurement of the cross section 22Ne(p,n)22Na. PMID- 9966139 TI - Two-particle rapidity correlations in dC, alpha C, and CC interactions at 4.2 GeV/c per nucleon. PMID- 9966140 TI - Shapes of 59Cu nuclei at moderate excitation energies and spin. PMID- 9966142 TI - Correlations between fragment mass and excitation energy in damped reactions. PMID- 9966141 TI - Contribution of two-pion annihilation to dilepton emission from proton-nucleon collisions. PMID- 9966143 TI - Deuteron photodisintegration near threshold. PMID- 9966144 TI - Production of polarized 8Li with the 7Li(d PMID- 9966145 TI - Preequilibrium emission of hard photons in proton-nucleus reactions. PMID- 9966146 TI - Hexadecapole strength in the region of the low-energy octupole resonance. PMID- 9966148 TI - Statistical multistep reactions: Application. PMID- 9966147 TI - Neutron pickup strength in 87Sr from the (p PMID- 9966149 TI - Differences in straggling for positrons and electrons. PMID- 9966150 TI - Polarization parameters of a spin-one system: Bounds and geometrical representation. PMID- 9966151 TI - Deducing the initial properties of hot nuclei formed in central heavy-ion collisions. PMID- 9966152 TI - Nuclear polarization effects due to classical dynamics of two colliding 238U nuclei with frictional forces. PMID- 9966154 TI - Instability of hot nuclei. PMID- 9966153 TI - delta -electron spectroscopy, a tool to study the dynamics of heavy-ion collisions. PMID- 9966156 TI - Excitation energy equilibration in damped 139La+40Ar collisions at 15 MeV per nucleon. PMID- 9966155 TI - Impact parameter and energy dependence of observables in intermediate energy heavy-ion reactions. PMID- 9966157 TI - Boltzmann-Uehling-Uhlenbeck and relaxation time methods: A comparison. PMID- 9966159 TI - Low-energy nucleon-nucleon scattering in a relativised quark model. PMID- 9966158 TI - Nucleus-nucleus multiplicity distributions and quantum chromodynamics. PMID- 9966160 TI - K+-nucleus total cross section analysis. PMID- 9966161 TI - Dirac random-phase-approximation analysis of the inelastic scattering of 500 MeV protons from 40Ca. PMID- 9966163 TI - Deuteron polarization observables and the Delta N interaction. PMID- 9966162 TI - Coupled channels analysis of 12C PMID- 9966164 TI - Nuclear orientation of 160Tb in Tb single crystal. PMID- 9966166 TI - Spatial correlation of pairing modes in nuclei at finite temperature. PMID- 9966165 TI - Microscopic investigation of pair excitation and shape coexistence in even-even nuclei. PMID- 9966167 TI - Generalized statistical self-consistent approach. PMID- 9966168 TI - Saturation effects in gamma-band energies. PMID- 9966169 TI - Pion-nucleon interaction and neutral-pion photoproduction on the proton near threshold. PMID- 9966170 TI - Energetic proton spectra in the promptly-emitted-particle model. PMID- 9966171 TI - Bound state effects on the parity-violating nuclear potential. PMID- 9966172 TI - Role of mesonic resonances in antiproton annihilation on nuclei. PMID- 9966173 TI - Gamow-Teller and M1 strength sums for sd shell nuclei by spectral distribution methods. PMID- 9966174 TI - Temporal development of the plasma phase transition. PMID- 9966175 TI - Comment on "Ring diagram nuclear matter calculations using Bonn and V14 potentials" PMID- 9966176 TI - Single-particle spectrum and ring-diagram nuclear matter calculations: A reply to a Comment. PMID- 9966177 TI - Comment on "Electron peaks in e++ Th, U, and Ta interactions" PMID- 9966178 TI - Reply to "Comment on 'Electron peaks in e++Th, U, and Ta interactions' " PMID- 9966179 TI - Skin thickness in the Te isotopes. PMID- 9966180 TI - Search for cold fusion using x-ray detection. PMID- 9966181 TI - Alpha-induced fission of 235U at extreme sub-barrier energies. PMID- 9966182 TI - Strength of tensor force and s-d-shell effective interactions. PMID- 9966183 TI - 180 degrees electron scattering from 14C. PMID- 9966184 TI - Spin dipole and quadrupole resonances in 40Ca. PMID- 9966185 TI - gamma width of the unbound 5.17 MeV level of 14O and the "hot" CNO cycle. PMID- 9966187 TI - Unitary theory of the deuteron photodisintegration. PMID- 9966186 TI - Important configurations in six-quark N-N states. II. Current quark model. PMID- 9966188 TI - Calculating deuteron photodisintegration amplitudes using nonsingular scattering equations. PMID- 9966190 TI - Protons of 200 MeV incident on 12C. I. Coincident proton emission from the continuum. PMID- 9966189 TI - 7+ states in 26Al observed in the 24Mg( alpha,d) and 25Mg(3He,d) reactions. PMID- 9966192 TI - Proton resonances in 34Cl from Ex=6.3 to 8.8 MeV. PMID- 9966191 TI - Protons of 200 MeV incident on 12C. II. Quasifree proton knockout. PMID- 9966193 TI - 17O(3He,d)18F reaction and its implication in the 17O destruction in the CNO cycle in stars. PMID- 9966194 TI - Gamow-Teller strength in the 208Pb(p,n)208Bi reaction at 134.3 MeV. PMID- 9966196 TI - Correction for truncation in coupled-channels optical potentials. PMID- 9966195 TI - First- and second-chance proton emission in the interactions of fast neutrons with 92Mo. PMID- 9966197 TI - Structure of the N=Z+1 nucleus 69Se. PMID- 9966198 TI - Evaluation of observables in statistical multifragmentation theories. PMID- 9966199 TI - Negative-parity excitations in 144Nd. PMID- 9966200 TI - Gyromagnetic ratios in 164Dy and 168Er. PMID- 9966202 TI - Two statistical approaches to nuclear disassembly. PMID- 9966201 TI - Fusion calculations for 40Ca PMID- 9966204 TI - Transverse hydrodynamics of collective pion flow. PMID- 9966203 TI - 24Mg nuclear moments from 24Mg(200 MeV)+208Pb scattering. PMID- 9966205 TI - High-energy gamma rays from reactions induced by E/A=15 MeV heavy-ion beams. PMID- 9966206 TI - Electromagnetic transition probabilities in the natural-parity rotational band of 173Yb. PMID- 9966208 TI - Transverse radius of an expanding hadronic system at freeze-out time. PMID- 9966207 TI - Binary decay of 56Ni formed in the 32S PMID- 9966209 TI - Systematic analysis of heavy-ion reaction data in terms of an eikonal approach: Elastic and inelastic scattering. PMID- 9966211 TI - Coherent surface excitation model for heavy-ion reactions: Energy and angular momentum conservation. PMID- 9966210 TI - Target excitation and angular momentum transfer in reactions of E/A=11.9 MeV 28Si with 181Ta from 4 pi charged particle, neutron, and gamma -ray multiplicity measurements. PMID- 9966212 TI - Systematic analysis of mass yield curves in low-energy fission of actinides. PMID- 9966213 TI - Strong interaction effects in high-Z K- atoms. PMID- 9966215 TI - Effect of configuration admixtures on pion double charge exchange. PMID- 9966214 TI - Relativistic and strong-distortion effects in proton-proton parity violation. PMID- 9966216 TI - Sigma -hypernuclear production in flight. PMID- 9966218 TI - Giant resonances at complex excitation energies. PMID- 9966217 TI - Spin-one Kemmer-Duffin-Petiau equations and intermediate-energy deuteron-nucleus scattering. PMID- 9966219 TI - Spin dependence of pp-->np pi + from 492 to 796 MeV. PMID- 9966220 TI - Pion-exchange contribution to the parity-violating asymmetry in p PMID- 9966221 TI - Soft-core baryon-baryon one-boson-exchange models. II. Hyperon-nucleon potential. PMID- 9966222 TI - Magnetic moment of the (3/2(-) PMID- 9966223 TI - Decay studies of neutron-deficient nuclei near the Z=64 subshell: 141Dy, 141Tb, 141Gdg+m, and 141Eum. PMID- 9966224 TI - Effect of nuclear core polarization on neutrinoless double beta decay of 48Ca. PMID- 9966225 TI - Hybrid method for calculating exciton state and level densities. PMID- 9966226 TI - Random-phase-approximation calculations of nuclear response in the continuum. PMID- 9966227 TI - Wentzel-Kramers-Brillouin-type approximations for bound states in short-range nonsingular potentials. PMID- 9966229 TI - Magnetic form factors of the trinucleons. PMID- 9966228 TI - Testing the parameters of the "universal" Woods-Saxon potential with B(E2;01+- >21+) values and nucleon separation energies. PMID- 9966230 TI - Gamma-ray spectroscopy of 60,61Zn and 59,60Cu. PMID- 9966231 TI - Nonspectral Dirac random-phase approximation for finite nuclei. PMID- 9966232 TI - Relations for the coefficients in the I(I+1) expansion for rotational spectra. PMID- 9966233 TI - Boson expansion theory description of anharmonic gamma vibrations in deformed nuclei. PMID- 9966234 TI - Two-level bosonic model that simulates the transition from a superconductive condensate to an alpha cluster condensate. PMID- 9966235 TI - Model calculations using boson mappings. PMID- 9966236 TI - Relativistic Vlasov approach to normal modes of nuclear matter. PMID- 9966237 TI - Seniority mapping of single fermion operators. PMID- 9966238 TI - Search for the tetraneutron using the reaction 4He( pi -, pi +)4n. PMID- 9966240 TI - Dilepton radiation from nucleon-nucleon collisions. PMID- 9966239 TI - Meson exchange currents in 209Bi. PMID- 9966242 TI - Double gamma decay in 90Zr. PMID- 9966241 TI - Coulomb excitation studies in antimony isotopes. PMID- 9966244 TI - Collective versus independent annihilation of "transhydrogen" antinuclei. PMID- 9966243 TI - np elastic scattering analyzing power characteristics at intermediate energies. PMID- 9966245 TI - Bidimensional fit to 2H( gamma,p)n cross-section values between 20 and 440 MeV. PMID- 9966246 TI - Path integral and boson-fermion expansion in many-fermion systems: Lipkin model. PMID- 9966247 TI - Pion absorption on polarized 3He. PMID- 9966248 TI - Comment on "Unexpected large deformations in 60Ni nuclei produced in the reaction 120 MeV 30Si+30Si" PMID- 9966249 TI - Reply to "Comment on 'Unexpected large deformations in 60Ni nuclei produced in the reaction 120 MeV 30Si PMID- 9966250 TI - Comment on "Pion-nucleon bremsstrahlung and Delta electromagnetic moments" PMID- 9966251 TI - Reply to "Comment on 'Pion-nucleon bremsstrahlung and Delta electromagnetic moments' " PMID- 9966252 TI - Erratum: Coupling between the beta and gamma vibration in tungsten nuclei PMID- 9966253 TI - High energy photon production in low energy 12C PMID- 9966254 TI - Quasifree analyzing powers using the (p PMID- 9966255 TI - One- and two-dimensional analysis of the factorial moments in 200 GeV/nucleon p, 16O, and 32S interactions with Ag and Br nuclei. PMID- 9966257 TI - Theoretical calculations for neutrino-induced charged current reactions in 12C and recent experimental results. PMID- 9966256 TI - Shape transition at high spin manifested in the gamma -ray decay of the giant dipole resonance in hot Dy nuclei. PMID- 9966258 TI - Application of the Bonn potential to proton-proton scattering. PMID- 9966260 TI - Polarization observables in deuteron photodisintegration and electrodisintegration. PMID- 9966259 TI - Total nuclear reaction probabilities and average cross sections for 27 to 92 MeV alpha particles in silicon. PMID- 9966261 TI - Equilibrium cluster emission from 3He+Ag reactions. PMID- 9966263 TI - Hard photons in proton-nucleus collisions. PMID- 9966262 TI - Nuclear dynamics of 192Os as probed in neutron scattering. PMID- 9966264 TI - Dynamics of collective excitations in 190,192Os and 194Pt observed by 8 MeV neutron scattering. PMID- 9966265 TI - Averaged nonstatistical effects in the 3s region for capture reactions. PMID- 9966266 TI - Importance of nucleon-nucleon interactions in hardening nucleon spectra in heavy ion fusion. PMID- 9966267 TI - Angular momentum effects in subbarrier fusion of 64Ni+100Mo. PMID- 9966268 TI - Determination of energies and widths of neutron-unbound states from heavy-ion collisions. PMID- 9966269 TI - Search for particle-bound neutral nuclei in heavy-ion-induced reactions. PMID- 9966270 TI - Nuclei with diffuse surfaces for future Boltzmann-Uehling-Uhlenbeck calculations. PMID- 9966271 TI - Transverse collective motion in intermediate-energy heavy-ion collisions. PMID- 9966272 TI - Fusion-evaporation cross sections for 24Mg PMID- 9966274 TI - Nucleon emission via electromagnetic excitation in relativistic nucleus-nucleus collisions: Reanalysis of the Weizsacker-Williams method. PMID- 9966273 TI - Collisional relaxation in simulations of heavy-ion collisions using Boltzmann type equations. PMID- 9966275 TI - Analysis of pre- and post-scission neutrons emitted in the reaction 169Tm(36Ar,f) at Elab PMID- 9966277 TI - High spin states in 75Kr: Approaching superdeformation in the A=80 region. PMID- 9966276 TI - Relativistic transport theory of fluctuating fields for hadrons. PMID- 9966278 TI - Modified statistical model for the disassembly of hot nuclei formed in intermediate-energy heavy-ion collisions. PMID- 9966279 TI - Spin correlation parameter and analyzing power in n-p elastic scattering at intermediate energies. PMID- 9966280 TI - Inclusive and exclusive quasielastic p PMID- 9966281 TI - Pion charge exchange to the isovector giant dipole state at energies above the 3 3 resonance. PMID- 9966283 TI - Two-nucleon absorption of stopped pi - in 3He. PMID- 9966282 TI - Antiproton annihilation at rest in nitrogen and deuterium gas. PMID- 9966285 TI - T20 problem and spin observables in pion-deuteron scattering. PMID- 9966284 TI - Pion double charge exchange in the Delta 33 resonance region. PMID- 9966286 TI - Analyzing powers in pi PMID- 9966287 TI - Half-life of 56Co. PMID- 9966289 TI - Decay of 133Nd and structure of 133Pr. PMID- 9966288 TI - Half-life of 229Th. PMID- 9966290 TI - Search for reflection asymmetric structures in the A=145 mass region: Decays of 1.8-s 143Cs to levels of 143Ba and 4.1-s 147La to levels of 147Ce. PMID- 9966291 TI - Shell-model study of 39S( beta -)39Cl and the energy levels of 39Cl. PMID- 9966292 TI - Charge distributions of 208Pb, 206Pb, and 205Tl and the mean-field approximation. PMID- 9966293 TI - Symplectic structure of the collective manifold. PMID- 9966294 TI - Sp6 <= crSscrU2 symmetry of the fermion dynamical symmetry model. PMID- 9966295 TI - Unique shape dependence in the coherent influence of signature on energies and M1 rates. PMID- 9966296 TI - Eigenvalue spacings of the shell-model Hamiltonian. PMID- 9966298 TI - Equation of state of cold nuclear matter extracted from nuclear masses by the droplet model. PMID- 9966297 TI - Triton model calculation test of the Bonn W-matrix rank-one approximation. PMID- 9966299 TI - Self-consistent structure of the S pair and the D pair in nuclei. PMID- 9966300 TI - New gamma ray in the decay of 56Co. PMID- 9966301 TI - Dominance of nucleon-nucleon bremsstrahlung in mass-asymmetric heavy-ion collisions at 15 MeV/nucleon. PMID- 9966302 TI - Can one observe the spin monopole resonance in 208Pb? PMID- 9966303 TI - Universality of temperature-dependent effects in finite many-fermion systems. PMID- 9966304 TI - Behavior of octupole states near mass 150 and the collapse of the Z=64 subshell gap. PMID- 9966305 TI - Hartree-Fock ansatz as saddle points of the convoluted Green's function. PMID- 9966306 TI - Partial-wave analysis of the pp-->pn pi + reaction. PMID- 9966307 TI - Limits on the presence of scalar and induced-scalar currents in superallowed beta decay. PMID- 9966308 TI - Possibility of transient effects during the emission of intermediate mass fragments. PMID- 9966310 TI - Subthreshold pion production: Similarity of p- and 12C-induced reactions. PMID- 9966309 TI - Observables in kaon photoproduction. PMID- 9966311 TI - Comment on "Nonresonant capture of low-energy protons by 27Al" PMID- 9966312 TI - Reply to "Comment on 'Nonresonant capture of low-energy protons by 27Al' " PMID- 9966313 TI - Comment on "Skeleton boson realizations of collective subalgebras" PMID- 9966314 TI - Multiconfiguration resonating-group theory of 8Li. PMID- 9966315 TI - Search for protons from the 2H(d,p)3H reaction in an electrolytic cell with Pd-Pt electrodes. PMID- 9966316 TI - Spin observables for polarized proton scattering from polarized 3He. PMID- 9966317 TI - Alpha-cluster spectroscopy in 40Ca and in the sd-shell closure region. PMID- 9966318 TI - Forward scattering of a proton from a J=1 nucleus: Selection rules for flipping the spin of the target by two units. PMID- 9966319 TI - Intermediate mass fragment emission in the 161-MeV p+Ag reaction. PMID- 9966320 TI - Measurement and analysis of the excitation function for alpha-induced reactions on Ga and Sb isotopes. PMID- 9966322 TI - Computer simulation of reaction plane memory via quasiparticle dynamics. PMID- 9966321 TI - alpha -like part of four-nucleon wave functions. PMID- 9966323 TI - Test of statistical model predictions for alpha-particle decay of 90,92,94,96Ru compound nuclei. PMID- 9966324 TI - Measurements of time delays for projectile-like fragments in the reaction 40Ar PMID- 9966325 TI - Midrapidity pi -/ pi + ratios in 1.05 GeV/nucleon 40Ca+40Ca collisions. PMID- 9966326 TI - Actinide cross sections from the reaction of 13C with 254Esg. PMID- 9966328 TI - Optical potential and the fusion barrier of two hot nuclei. PMID- 9966327 TI - Strength of the attraction of the Skyrme-type forces used in the heavy-ion reaction problems. PMID- 9966329 TI - Off-mass-shell dynamics in the calculation of deep inelastic scattering from nucleons and nuclei. PMID- 9966330 TI - Measurement of deuteron-deuteron total cross sections in the incident momentum range 1.5-4.0 GeV/c. PMID- 9966331 TI - Pion-deuteron breakup reaction at 228 MeV. PMID- 9966333 TI - Neutral pion photoproduction on the nucleon near threshold. PMID- 9966332 TI - Observation of double isovector giant dipole resonances from pion double charge exchange. PMID- 9966334 TI - Flow effects on transverse momentum spectra in ultrarelativistic nuclear collisions. PMID- 9966336 TI - Nuclear magnetic moment of 106Rh. PMID- 9966335 TI - Meson-exchange enhancement of the first-forbidden 96Yg(0(-))-->96Zrg (0(+)) beta transition: beta decay of the low-spin isomer of 96Y. PMID- 9966337 TI - Half-life of 10C. PMID- 9966339 TI - Low-energy octupole modes in the A=24-54 region. PMID- 9966338 TI - Pairing effects in N=82 isotones. PMID- 9966340 TI - Covariant mean-field calculations of finite-temperature nuclear matter. PMID- 9966341 TI - Possible evidence for four-particle, four-hole excitations in 146Gd. PMID- 9966342 TI - Number-conserving random phase approximation with analytically integrated matrix elements. PMID- 9966343 TI - Pairing correlations in the rotating nucleus discussed within the generator coordinate method. PMID- 9966344 TI - Charge form factors of the three- and four-body nuclei. PMID- 9966346 TI - Shell model states in the 18O three-body wave function. PMID- 9966345 TI - Generalized valley approximation applied to a schematic model of the monopole excitation. PMID- 9966347 TI - Large basis space effects in electron scattering form factors of light nuclei. PMID- 9966348 TI - Approximate energy correction for particle number symmetry breaking in constrained Hartree-Fock plus BCS calculations. PMID- 9966349 TI - Monopole strength and shape coexistence in the A PMID- 9966350 TI - Electrofission of 208Pb in the intermediate energy region. PMID- 9966351 TI - Half-life and branching ratios of 13O beta decay. PMID- 9966353 TI - Quark physics at multi-GeV electron beam accelerators. PMID- 9966352 TI - Q2 dependence of the European Muon Collaboration effect. PMID- 9966355 TI - Electric quadrupole excitations in the interactions of 89Y with relativistic nuclei. PMID- 9966354 TI - Dirac potentials in a coupled channel approach to inelastic scattering. PMID- 9966356 TI - Spurious states in quasiparticle theory. PMID- 9966357 TI - Spin observables and reconstruction of transverse amplitudes in p-d elastic scattering. PMID- 9966358 TI - Ad hoc Coulomb corrections to the radiation tail. PMID- 9966360 TI - Effect of trajectory fluctuations on nucleon drift and diffusion in deep inelastic heavy ion collisions. PMID- 9966359 TI - Information on effective interactions from experimental single-particle energies. PMID- 9966361 TI - Thermodynamics of Strutinsky shell corrections and nuclear level densities at low excitations. PMID- 9966362 TI - Comment on "Unified treatment of bound-state and scattering problems" PMID- 9966363 TI - Absence of parity effects in preequilibrium gamma emission. PMID- 9966365 TI - Erratum: Two-loop corrections for nuclear matter in the Walecka model PMID- 9966364 TI - Reply to "Absence of parity effects in preequilibrium gamma emission" PMID- 9966366 TI - Quadrupole moments and band-mixing in tungsten nuclei. PMID- 9966367 TI - Critical excitation energy in fusion-evaporation reactions. PMID- 9966368 TI - Observation of superdeformation in 192Hg. PMID- 9966369 TI - Superdeformed band in 192Hg. PMID- 9966371 TI - Kaon versus pion interferometry signatures of quark-gluon plasma formation. PMID- 9966370 TI - Resonances due to the Landau-Zener transition. PMID- 9966372 TI - Occupation probabilities and hole-state strengths in nuclear matter. PMID- 9966373 TI - 16O( pi +,2p) reaction at 165 MeV. PMID- 9966374 TI - Fast E1 transitions and evidence for octupole-octupole and quadrupole-octupole excitations in 144Sm. PMID- 9966376 TI - Theoretical angular distributions from coherent subthreshold pion production. PMID- 9966375 TI - Neutron emission and energy partition in the inelastic reactions of 154 MeV 32S on 100Mo. PMID- 9966378 TI - Analyzing multiparticle reactions. I. Unitarizing perturbative amplitudes. PMID- 9966377 TI - W-matrix method for the representation of the scattering T matrix: Analytical example. PMID- 9966379 TI - Analyzing multiparticle reactions. II. Exactly solvable production models. PMID- 9966380 TI - Electroexcitation of rotational bands in 18O. PMID- 9966382 TI - Relativistic contributions to the deuteron electromagnetic form factors. PMID- 9966381 TI - Valence capture mechanism in resonance neutron capture by 13C. PMID- 9966384 TI - Formation of isomers in the reaction 238U(p,3n)236Np. PMID- 9966383 TI - Nuclear structure of 238Np from neutron-capture and alpha -decay measurements. PMID- 9966385 TI - Possible static octupole deformation at high angular momentum in 78Kr and 126,128Ba. PMID- 9966386 TI - Total charge and mass changing cross sections of relativistic nuclei in hydrogen, helium, and carbon targets. PMID- 9966387 TI - Individual charge changing fragmentation cross sections of relativistic nuclei in hydrogen, helium, and carbon targets. PMID- 9966388 TI - Individual isotopic fragmentation cross sections of relativistic nuclei in hydrogen, helium, and carbon targets. PMID- 9966389 TI - Formula for calculating partial cross sections for nuclear reactions of nuclei with E >~ 200 MeV/nucleon in hydrogen targets. PMID- 9966390 TI - Dilepton as a possible signature for the baryon-rich quark-gluon plasma. PMID- 9966391 TI - Two-nucleon-transfer form factors in heavy rotational nuclei. PMID- 9966392 TI - Projectile breakup in the 27Al(16O,X) reaction at 72, 84, 96, 110, and 125 MeV bombarding energies. PMID- 9966393 TI - Electromagnetic transition strengths between high spin states in 79Sr and 80Sr. PMID- 9966394 TI - Electron-capture-delayed fission properties of 234Am. PMID- 9966395 TI - Spontaneous fission properties of 2.9-s 256No. PMID- 9966396 TI - Prompt neutron emission from the spontaneous fission of 260Md. PMID- 9966397 TI - Deuteron electromagnetic form factors in a chiral quark model. PMID- 9966399 TI - Pionic contributions to deep inelastic nuclear structure functions. PMID- 9966398 TI - 14N( gamma, pi +)14Cgs at photon energies of 230, 260, and 320 MeV. PMID- 9966400 TI - Coupled-channels study of antiproton-proton reactions. PMID- 9966401 TI - Recoil momenta in proton-induced spallation reactions. PMID- 9966402 TI - Interacting boson fermion model description for the levels of 71Ge39 populated in the beta decay of 65.30-h 71As. PMID- 9966403 TI - Fermi surface anomaly and depletion of the Fermi sea in the relativistic Brueckner-Hartree-Fock approximation. PMID- 9966405 TI - Competing proton and neutron rotational alignments: Band structures in 131Ba. PMID- 9966404 TI - Stability conditions in the Thomas-Fermi approximation and small amplitude vibrations in the Vlasov equation. PMID- 9966406 TI - Analytic formulae for interacting boson model matrix elements in the SU(3) basis. PMID- 9966407 TI - Cluster-orbital shell model with continuum discretization and its application to the He isotopes. PMID- 9966409 TI - Medium effects in electric form factors and transition strengths. PMID- 9966410 TI - K representation for odd-odd nuclei in the interacting boson-fermion-fermion model. II. Band mixing in the normal and conflicting case and electromagnetic properties. PMID- 9966411 TI - Resonant and nonresonant contributions to the photoactivation of 111Cd. PMID- 9966408 TI - Constraints on the self-consistent relativistic Fermi-sea particle formalism in the quantum hadrodynamical model. PMID- 9966413 TI - Decay of 226Ra by 14C emission. PMID- 9966412 TI - Low lying states in 127Xe: Implications for the efficiency of a 127I solar nu detector. PMID- 9966414 TI - Rotational g factors of 158Er at low spins. PMID- 9966415 TI - Quenching of spin-dipole strength in 40Ca. PMID- 9966416 TI - Effect of the continuum on thermally induced phase transitions in nuclei. PMID- 9966417 TI - Reconstruction of isospin and spin-isospin symmetries and double beta decay. PMID- 9966418 TI - Three paths for intermediate-mass fragment formation at a near-onset excitation energy of 1.3 MeV/nucleon. PMID- 9966420 TI - Transverse form factors in the Riemann rotational model. PMID- 9966419 TI - Effects of singlet breakup on deuteron elastic scattering at intermediate energies. PMID- 9966421 TI - Full-folding optical potentials in elastic proton-nucleus scattering. PMID- 9966423 TI - Relation among theories of inclusive breakup reactions. PMID- 9966422 TI - Reaction 2H(e,e')pn near breakup threshold at backward angles. PMID- 9966424 TI - Gauge dependence of nonrelativistic calculations of deuteron photodisintegration. PMID- 9966425 TI - Fine structure of the 1g9/2 isobaric analog resonance in 61Cu. PMID- 9966426 TI - Mechanism for electric dipole transitions from the broad p-wave neutron resonance in 24Mg. PMID- 9966428 TI - Deuteron Compton scattering. PMID- 9966427 TI - Microscopic approach for the n-d effective interaction. PMID- 9966429 TI - Isomeric yield ratios in proton-, 3He-, and alpha -particle-induced reactions on 197Au. PMID- 9966430 TI - Asymptotic D-state to S-state ratio of the deuteron. PMID- 9966431 TI - Sub-barrier fusion of 27Al+70,72,73,74,76Ge: Evidence for shape transition and structure effects. PMID- 9966432 TI - Heavy-ion Coulomb excitation and photon decay of the giant dipole resonance in 208Pb. PMID- 9966433 TI - Dispersion relation for effective interactions. PMID- 9966434 TI - Particle stability of the isotopes 26O and 32Ne in the reaction 44 MeV/nucleon 48Ca+Ta. PMID- 9966435 TI - Nucleon exchange properties of the E/A=8.5 MeV 74Ge+165Ho reaction. PMID- 9966436 TI - Heat partition in the E/A=8.5 MeV 74Ge+165Ho reaction. PMID- 9966438 TI - Sub-barrier fusion of 28,30Si with 24,26Mg. PMID- 9966437 TI - Changes in target fragmentation mechanisms with increasing projectile energy in intermediate energy nuclear collisions. PMID- 9966439 TI - Theory of transfer reactions in peripheral heavy-ion collisions. PMID- 9966440 TI - Electromagnetic dissociation of 32S at ultrarelativistic energy in nuclear emulsion. PMID- 9966442 TI - Low-energy reactions with heavy deformed nuclei. PMID- 9966441 TI - Energy dependence of fusion evaporation-residue cross sections in the 28Si+28Si reaction. PMID- 9966444 TI - Analytically soluble model for fusion time. PMID- 9966443 TI - Coupled reaction channels effects in the elastic scattering of 32,36S+58,64Ni. PMID- 9966445 TI - Direct measurement of the branching ratio Gamma n/ Gamma f of 238U in inelastic alpha scattering in the giant resonance region. PMID- 9966446 TI - Measurement of the neutrons emitted in the proton-induced fission of 209Bi and 238U at 475 MeV. PMID- 9966447 TI - Search for radiative transitions in the hypernucleus Lambda 10B. PMID- 9966448 TI - Pion-nucleus scattering at high energies. PMID- 9966449 TI - Coulomb-nuclear interference in pion inelastic scattering. PMID- 9966451 TI - Separable multichannel model for the nucleon-nucleon interaction with Delta isobars. PMID- 9966452 TI - Realistic microscopic approach to deep inelastic scattering of electrons off few nucleon systems. PMID- 9966450 TI - Quasielastic electron scattering and Coulomb sum rule in 4He. PMID- 9966453 TI - Coexistence features in the spherical-deformed A PMID- 9966454 TI - Single-particle states in 151Tm and 151Er: Systematics of neutron states in N=83 nuclei. PMID- 9966455 TI - Subnanosecond lifetime measurements in Y and Sr nuclei and the saturation of deformation near A=100. PMID- 9966456 TI - Mass systematics for A=29-44 nuclei: The deformed A~32 region. PMID- 9966457 TI - 02+ and 03+ states in 110Cd. PMID- 9966458 TI - Interacting-boson-fermion-fermion model description of 140La83 and comparison with levels populated by beta decay and neutron capture. PMID- 9966460 TI - Consistent microscopic study of the low-energy 5Li spectrum. PMID- 9966459 TI - Role of deformation in exotic decay studies. PMID- 9966462 TI - Local gauge invariance of nonlocal interactions. PMID- 9966461 TI - Quark tunneling in a one-dimensional nuclear model. PMID- 9966463 TI - High-spin structure of N=51 (9)6Rh and 97Pd: A shell-model study. PMID- 9966465 TI - Orbital rotational vibrations in the A=130 mass region. PMID- 9966464 TI - Instability of infinite nuclear matter in the sigma - omega model. PMID- 9966467 TI - High-spin states in 76Br. PMID- 9966466 TI - Collective Hamiltonian in linked diagram expansions. PMID- 9966468 TI - Three- and five-quasiparticle high-spin states in 143Nd. PMID- 9966469 TI - Thermal neutron capture in silicon. PMID- 9966470 TI - Determination of 86Zr and 88Mo atomic masses by the ( alpha,8He) reactions on 90Zr and 92Mo. PMID- 9966471 TI - Analyzing powers for p PMID- 9966472 TI - Lifetime measurement of excited states in 121,123Te. PMID- 9966473 TI - Continuum background in the giant resonance region of excitation. PMID- 9966474 TI - Supersymmetric quantum mechanics, the Pauli principle, and nucleon-alpha scattering. PMID- 9966475 TI - Intermittency and relativistic heavy-ion Monte Carlo simulators. PMID- 9966476 TI - Elastic scattering of kaons on nuclei. PMID- 9966477 TI - Dipole strength function in 11Li. PMID- 9966479 TI - pi 0 photoproduction on the neutron near threshold. PMID- 9966478 TI - Topological soliton model calculation of the proton-proton parity-violating interaction. PMID- 9966480 TI - Quasifree fragmentation of radioactive projectiles: Extended Serber model. PMID- 9966481 TI - Many-body correlations and the truncation of the shell-model Hilbert space. PMID- 9966482 TI - Double Gamow-Teller matrix elements in the germanium region. PMID- 9966483 TI - Erratum: Pion scattering to 4(-) states in 14C PMID- 9966484 TI - Erratum: Inclusive production of K+ mesons in 2.1-GeV/nucleon nuclear collisions PMID- 9966485 TI - Reaction cross sections for nu 13C-->e- 13N and nu 13C--> nu ' 13C* for low energy neutrinos. PMID- 9966486 TI - Faddeev calculations for low-energy p-d scattering. PMID- 9966487 TI - Off-shell T matrices from inverse scattering. PMID- 9966488 TI - Differential cross sections at low energies for 2H(d,p)3H and 2H(d,n)3He. PMID- 9966489 TI - Microscopic calculation of bremsstrahlung emission in 3He+ alpha collisions. PMID- 9966491 TI - Phase shift analysis of all proton-proton scattering data below Tlab=350 MeV. PMID- 9966490 TI - Charged particle decay from giant monopole resonance in 28Si. PMID- 9966492 TI - Off-shell behavior of relativistic NN effective interactions and charge symmetry breaking. PMID- 9966493 TI - Parity nonconserving asymmetries in resonance scattering and nuclear reactions induced by polarized protons. PMID- 9966494 TI - Excitation of two-particle-one-hole high-spin states in the 45Sc(p,n)45Ti reaction at 136 MeV. PMID- 9966495 TI - Gamow-Teller strength in the 54Fe(p,n)54Co reaction at 135 MeV. PMID- 9966496 TI - Asymmetry of spin-flip of polarized protons in the inelastic scattering to the first 2(+) states of 48Ti and 50Ti. PMID- 9966497 TI - Relaxation of angular momentum in fission and quasifission reactions. PMID- 9966499 TI - 12C+12C elastic scattering analysis above E/A=6 MeV using deep real potentials. PMID- 9966498 TI - Electromagnetic dissociation of 28Si at Elab/A=14.6 GeV by nucleon emission. PMID- 9966500 TI - Nuclear deformation in excited Pb isotopes from giant dipole gamma -ray-fission angular correlations. PMID- 9966501 TI - Transverse momenta, nuclear equation of state, and momentum-dependent interactions in heavy-ion collisions. PMID- 9966502 TI - Conversion electron and yrast state measurements in 73Br. PMID- 9966503 TI - Statistical equilibrium in the 40Ar+12C system at E/A=8 MeV. PMID- 9966504 TI - High-spin states in 136Ce: Systematics of collective oblate rotation. PMID- 9966505 TI - Fusion cross sections for 46,50Ti+90Zr,93Nb and some systematics of heavy-ion fusion at barrier and subbarrier energies. PMID- 9966506 TI - Isomers in iodine nuclei. PMID- 9966508 TI - Coulomb-modified Glauber model description of heavy-ion reaction cross sections. PMID- 9966507 TI - Angular correlations between heavy and light fragments in the reaction 32S+26Mg at Elab=163.5 MeV. PMID- 9966509 TI - Electrofission in the quasifree and delta regions. PMID- 9966511 TI - Optical potentials for charged-hadron-nucleus scattering: Role of Coulomb excitations. PMID- 9966510 TI - Pion elastic and inelastic scattering from 24Mg and 26Mg. PMID- 9966513 TI - Phenomenology of quasifree scattering. PMID- 9966512 TI - Cross sections, analyzing powers, and spin-rotation-depolarization observables for 500 MeV proton elastic scattering from 12C and 13C. PMID- 9966514 TI - 50 MeV pi + and pi - scattering from 12C. PMID- 9966515 TI - Constituent-quark contribution to lepton-nucleus deep-inelastic scattering. PMID- 9966516 TI - Radiative capture of kaons by the deuteron and the Lambda -n scattering lengths. PMID- 9966517 TI - Pion-nucleon scattering from 2 to 5 GeV/c. PMID- 9966518 TI - Strangeness production in antiproton annihilation on nuclei. PMID- 9966519 TI - Measurement of the beta spectral shapes of 12B and 12N. PMID- 9966520 TI - Two-photon decay of the first excited 0(+) state in 16O. PMID- 9966521 TI - Constraints on the 12C( alpha, gamma )16O astrophysical S factor from the beta delayed alpha emission of 16N. PMID- 9966522 TI - Exotic decay model and alpha decay studies. PMID- 9966523 TI - Nuclear matter properties from a separable representation of the Paris interaction. PMID- 9966524 TI - Boson effective charges for light Se, Kr, and Sr isotopes. PMID- 9966525 TI - Relativistic quasiparticle description of the structure of finite nuclei. PMID- 9966526 TI - Comparison between effective Hamiltonians in symmetry restoring theories: Intrinsic excitations in superfluid nuclei. PMID- 9966528 TI - Vacuum polarization currents in finite nuclei. PMID- 9966527 TI - Renormalized particle-particle and particle-hole random-phase approximation correlations at finite temperature: Effects upon the nuclear level density parameter. PMID- 9966529 TI - Band mixing effects in mean field theories. I. E2 transitions in the interacting boson model 1. PMID- 9966530 TI - K structure of the cranked shell model wave function. PMID- 9966531 TI - Core excited states in 210Po and 206Pb. PMID- 9966532 TI - Projection operator in the boson expansion techniques. PMID- 9966533 TI - Experimental test of a newly proposed empirical relationship between the centroid and width of the giant quadrupole resonance and the neutron binding energy of the nucleus. PMID- 9966534 TI - Quasifree reaction mechanism in 2H(6Li,3He alpha )n at E0=21.6-33.6 MeV. PMID- 9966536 TI - Dependence of the European Muon Collaboration effect on nuclear structure. PMID- 9966535 TI - Evaluation of Dirac sea effects in a finite system. PMID- 9966537 TI - Contribution of the two-body transverse current to the non-energy-weighted sum rule for electron scattering. PMID- 9966538 TI - Inertias of superdeformed bands. PMID- 9966539 TI - Quantum size effects in rapidly rotating nuclei. PMID- 9966540 TI - Comment on "Simultaneous analyses of elastic scattering and fusion cross sections for the 32S+58,64Ni systems at energies near the Coulomb barrier" PMID- 9966541 TI - Erratum: Coupled channels analysis of 12C( pi, pi ) at low energy PMID- 9966542 TI - Line shapes and lifetimes in the 135Nd superdeformed band. PMID- 9966543 TI - Compound and precompound effects in photon decay of the giant dipole resonance. PMID- 9966544 TI - Isovector parity mixing in 20Ne. PMID- 9966546 TI - Spins and spin alignments in 16O+16O inelastic scattering. PMID- 9966545 TI - Composite particle emission following negative pion absorption on 12C at T pi =165 MeV. PMID- 9966547 TI - Phase variation of the nucleon-nucleon amplitude and the spin observables in proton-4He elastic scattering. PMID- 9966549 TI - Dielectron production in proton-nucleus reactions. PMID- 9966548 TI - Information on octupole deformation from the systematics of B(E3;01+-->31-) values. PMID- 9966550 TI - Azimuthal asymmetry in Ar+V collisions from E/A=35 to 85 MeV. PMID- 9966551 TI - Particle-particle correlations and lifetimes of composite nuclei: New tests for the evaporation model and for statistical equilibration. PMID- 9966552 TI - Decays of 134Sn and O- 134Sb. PMID- 9966553 TI - Evidence for the onset of reflection asymmetry in 216Fr. PMID- 9966554 TI - Upper limit for neutron emission from cold d-t fusion. PMID- 9966556 TI - Energy shifts and widths of kaonic atoms. PMID- 9966555 TI - Additional evidence for fusion-fission in 32S+24Mg reactions: Division of excitation energy and spin in the fission fragments. PMID- 9966557 TI - Relativistic effects in low-energy nucleon-nucleon scattering. PMID- 9966559 TI - Is thermal equilibrium in strongly damped collisions only apparent? PMID- 9966558 TI - s-wave partial cross sections for the reaction p+p-->p+p+ pi 0. PMID- 9966560 TI - (p,n) reaction on Li isotopes for Ep=60-200 MeV. PMID- 9966562 TI - Test of gamma-ray strength functions in nuclear reaction model calculations. PMID- 9966561 TI - Resonances in continuous spectra of three-body systems with finite-range two-body interaction. PMID- 9966563 TI - 30Si(3He,d)31P reaction at 25 MeV. PMID- 9966564 TI - Negative-parity states in the spectrum of 6Li from elastic scattering and radiative capture of 3He by 3H. PMID- 9966565 TI - Analog (p,n) cross sections of even-even palladium isotopes at 26 MeV. PMID- 9966566 TI - Determination of 200Pb, 204Po, 208Rn, 212Ra, and 216Th atomic masses by the 204Pb( alpha,8He)200Pb reaction. PMID- 9966567 TI - Preequilibrium (p,n) reaction as a probe for the effective nucleon-nucleon interaction in multistep direct processes. PMID- 9966569 TI - Optical-model analysis of 14N+12C and 12C+12C elastic scattering in the range Ec.m.=35 to 63 MeV. PMID- 9966568 TI - 12C-12C potential by inversion. PMID- 9966570 TI - Yrast transition strengths in 76Br. PMID- 9966571 TI - Reaction mechanisms and their interaction time in dissipative heavy-ion collisions. PMID- 9966572 TI - Lifetimes of high spin states in 181Ir and 180Os. PMID- 9966573 TI - Spin dependence of the giant-dipole-resonance strength function in highly excited nuclei in the mass region A=39-45. PMID- 9966575 TI - Distribution of cluster sizes from evaporation to total multifragmentation. PMID- 9966574 TI - Heavy actinide production from the interactions of 40Ar with 248Cm and a comparison with the 44Ca-248Cm system. PMID- 9966576 TI - Deformation effects in the compound nucleus decay using the spin-alignment method. PMID- 9966577 TI - Angular momentum dependent absorption in 6Li scattering. PMID- 9966578 TI - Nucleon momentum distribution in colliding nuclei and potential between excited nuclei studied with the Vlasov equation. PMID- 9966579 TI - Nuclear friction and chaotic motion. PMID- 9966580 TI - Search for valence proton effects in sub-barrier fusion reactions. PMID- 9966582 TI - Nonrelativistic full-folding model of nucleon elastic scattering at intermediate energies. PMID- 9966581 TI - Prescission and postscission neutrons from the reactions p+235,236,238U with Ep <= 25.6 MeV. PMID- 9966583 TI - Absolute differential cross sections for pi +/-p elastic scattering at 30 <= T pi <= 67 MeV. PMID- 9966585 TI - Theory of deep-inelastic scattering from light nuclei. PMID- 9966584 TI - Reaction 58Ni( pi +,pp) at T pi +=160 MeV. PMID- 9966586 TI - Asymmetry in deep-inelastic scattering of polarized leptons from polarized 2H and 3He. PMID- 9966588 TI - Full folding calculations for proton-nucleus elastic scattering at intermediate energies. PMID- 9966587 TI - Analysis of pion scattering to stretched states in 60Ni and other nuclei using Woods-Saxon wave functions. PMID- 9966589 TI - Parity-violating asymmetry in p PMID- 9966590 TI - Theory of the isotensor term in the pion-nucleus optical potential. PMID- 9966591 TI - Correlation observables in (p,p' gamma ) reactions. PMID- 9966592 TI - Single pion production in nucleon-nucleon collisions. PMID- 9966593 TI - Separable nucleon-nucleon potential with delta isobar degrees of freedom. PMID- 9966595 TI - Directional correlations of gamma transitions in 142Ce. PMID- 9966594 TI - Pion-nucleus scattering around the (3,3) resonance. PMID- 9966596 TI - Half-lives of 44Ti and 207Bi. PMID- 9966597 TI - Energy levels and transition probabilities in the neutron-rich lanthanide nucleus 156Sm. PMID- 9966598 TI - Time-dependent Hartree-Fock-Bogoliubov approximation and nonintegrable quantum phase. PMID- 9966600 TI - Uncertainties in the two-nucleon potential and nuclear matter predictions. PMID- 9966599 TI - Pair condensates in realistic shell model states. I. 56Fe and 58Fe. PMID- 9966602 TI - Electromagnetic properties of some positive parity dipole states described in terms of quadrupole and octupole interacting bosons. PMID- 9966601 TI - Quark-meson model for nuclear force. PMID- 9966603 TI - Tensor coupling of the rho meson in a chiral confining model. PMID- 9966604 TI - Influence of symmetry-conserving higher order interactions in the interacting boson model on the first beta and gamma band in rotational nuclei. PMID- 9966605 TI - Mixed-symmetry states in 144Nd: Semimicroscopic accounting within the cluster vibration model and its mapping into the interacting boson model. PMID- 9966606 TI - Quantum chaos for exact and broken K quantum number in the interacting-boson model. PMID- 9966607 TI - Exclusive photonuclear reactions and asymptotic scaling. PMID- 9966608 TI - Transition strengths in 79Sr. PMID- 9966610 TI - Z dependence of Coulomb dissociation cross sections in heavy ion reactions. PMID- 9966609 TI - New test of the excited state population method for measurements of nuclear temperatures. PMID- 9966611 TI - 0 PMID- 9966612 TI - Measurement of the half-life of 8Li. PMID- 9966613 TI - Experimental examination of the lowest alpha cluster states in 44Ti. PMID- 9966615 TI - Revised width for the 13C(p, gamma )14N resonance at 550 keV. PMID- 9966616 TI - "Missing" 19/2(+) states in 141Pr and 143Pm. PMID- 9966614 TI - alpha -transfer contribution to 9Be+13C elastic and inelastic scattering. PMID- 9966618 TI - Deuteron form factors and the short-range structure of the deuteron. PMID- 9966617 TI - Isospin breaking in the analyzing power of 3H(3He,2H)4He and the inverse reaction. PMID- 9966619 TI - Cascade calculation of subthreshold pi 0 production. PMID- 9966620 TI - Quasifree production of Sigma 's in the reaction 12C(K-, pi +). PMID- 9966621 TI - Optical model calculations of large-angle excitation functions for pion-nucleus scattering. PMID- 9966623 TI - Dynamical scaling in multifragmentation reactions. PMID- 9966622 TI - Thermal decay rate of multidimensional fission under a nonlinear coupling. PMID- 9966624 TI - One-quasiparticle coupling to a Bohr core. PMID- 9966625 TI - Influence of shell effects and stable octupole deformation on the E1 and E2 transition rates in the heavy-Ba region. PMID- 9966626 TI - Nucleon spectral function in complex nuclei and nuclear matter and inclusive quasielastic electron scattering. PMID- 9966627 TI - Imaginary part of the nucleon self-energy in a relativistic field theory. PMID- 9966628 TI - Microscopic study of the 238U-238U system and anomalous pair production. PMID- 9966629 TI - Scattering of polarized protons from 6Li at 200 MeV. PMID- 9966630 TI - Effective interactions and nuclear structure using 180 MeV protons. I. 16O(p,p'). PMID- 9966631 TI - Effective interactions and nuclear structure using 180 MeV protons. II. 28Si(p,p'). PMID- 9966632 TI - Effective interactions and nuclear structure using 180 MeV protons. III. 30Si(p,p'). PMID- 9966633 TI - Predictions of the Paris N-N potential for three-nucleon continuum observables: Comparison of two approaches. PMID- 9966634 TI - Upper limits to fusion rates of isotopic hydrogen molecules in Pd. PMID- 9966635 TI - Zero-degree cross sections for the 7Li(p,n)7Be(g.s.+0.43-MeV) reaction in the energy range 80-795 MeV. PMID- 9966636 TI - 12C(n, gamma 0)13C cross section in the 8-11 MeV region. PMID- 9966638 TI - Light fragment emission as studied by the (p,pHe) reactions on Be and Ag with 300 MeV protons. PMID- 9966637 TI - Collective doorway configurations in 49Ca through neutron scattering on 48Ca. PMID- 9966639 TI - Electron scattering from 92Mo. PMID- 9966641 TI - Treatment of the Coulomb interaction in momentum space calculations of proton elastic scattering. PMID- 9966640 TI - Limitation of the linear momentum transfer in 4He+59Co collisions. PMID- 9966642 TI - Excitation and fission decay of 238U using the (17O,17O') reaction. PMID- 9966643 TI - Rotational bands in 135Ce: Collective prolate and oblate rotation. PMID- 9966645 TI - Electromagnetic dissociation of relativistic heavy ions. PMID- 9966644 TI - Breakup of the projectile at 35 MeV/nucleon. PMID- 9966646 TI - Search for a valence-neutron-induced enhancement in the sub-barrier fusion of 32S+12,13C. PMID- 9966647 TI - Quasiparticle alignment in the most deformed krypton isotope 74Kr. PMID- 9966648 TI - Spin alignment and resonance behavior in the 24Mg+24Mg system. PMID- 9966649 TI - High-spin states in doubly odd 122Cs. PMID- 9966650 TI - One-nucleon-transfer reactions induced by 20Ne at 500 and 600 MeV. PMID- 9966651 TI - Investigation of spin-isospin strength in 48Ca-->48Sc and 90Zr-->90Nb using the (6Li,6He) reaction. PMID- 9966653 TI - np phase shifts, 142 to 800 MeV. PMID- 9966652 TI - Sub-barrier fusion in a macroscopic model of nuclear shape evolutions. PMID- 9966654 TI - Bound states, resonances, and poles in low-energy K-barN interaction models. PMID- 9966655 TI - Investigating fundamental antiproton-nucleon interactions by means of p-bar nucleus elastic scattering. PMID- 9966657 TI - Global Dirac optical potentials for elastic proton scattering from heavy nuclei. PMID- 9966656 TI - Analyzing power measurement for forward angle n-p scattering at 790 MeV. PMID- 9966658 TI - Structure functions of nuclei in the "instant" form of dynamics. PMID- 9966660 TI - Superratio and the simple ratios of pi + and pi - elastic scattering on 3H and 3He at 180 MeV to investigate charge symmetry. PMID- 9966659 TI - Nuclear charge symmetry breaking and quantum-chromodynamically-induced corrections to quantum electrodynamics. PMID- 9966662 TI - Hypertriton: Lambda Sigma conversion and tensor forces. PMID- 9966661 TI - Electroexcitation of the N* (1440) in the relativistic constituent quark model. PMID- 9966663 TI - Negative pion-nucleus elastic scattering at 30 and 50 MeV. PMID- 9966664 TI - Three-spin measurements in pp-->pp at 730 MeV. PMID- 9966665 TI - Effective interactions for nucleon-nucleus scattering above 300 MeV. PMID- 9966667 TI - Off-shell form factors and low energy theorems for pion photoproduction. PMID- 9966666 TI - Spin-flip isovector giant resonances from the 90Zr(n,p)90Y reaction at 198 MeV. PMID- 9966668 TI - Momentum-space analysis of the nuclear partial transitions in the charged pion photoproduction. PMID- 9966669 TI - Half-life of 176Lu. PMID- 9966670 TI - Systematics of nuclear ground state properties in 78-100Sr by laser spectroscopy. PMID- 9966671 TI - Negative-parity states of odd Xe and Ba isotopes in the interacting boson-fermion model. PMID- 9966672 TI - Nuclear Ramsauer effect and the isovector potential. PMID- 9966673 TI - K pi =0(+) band moment of inertia anomaly. PMID- 9966675 TI - (6Li,6He) reaction and Gamow-Teller beta decay. PMID- 9966674 TI - Masses of stable xenon isotopes: Check for internal consistency via ion cyclotron resonance mass spectrometry. PMID- 9966676 TI - Analyzing power measurements for elastic scattering of 17 MeV neutrons from 120Sn. PMID- 9966678 TI - Shape difference implied by quenched Coriolis interaction in 175Os. PMID- 9966677 TI - 12C(28Si,X)11C cross section at 13.4 GeV nucleon. PMID- 9966680 TI - Electrodisintegration of the deuteron in nuclear reactions. PMID- 9966679 TI - SU(3) limit of the interacting boson model as a 1/N expansion. PMID- 9966681 TI - Dispersive contribution to 6Li+12C, 58Ni real potential. PMID- 9966682 TI - Erratum: Photodisintegration of the deuteron with elliptically polarized gamma rays PMID- 9966683 TI - Transverse electrodisintegration of the deuteron in the threshold region at high Q2. PMID- 9966684 TI - 34 micros isomer at high spin in 212Fr: Evidence for a many-particle octupole coupled state. PMID- 9966685 TI - Disappearance of flow and its relevance to nuclear matter physics. PMID- 9966686 TI - Azimuthal distributions of fission fragments and alpha particles emitted in the reactions 36Ar+238U at E/A=20 and 35 MeV and 14N+238U at E/A=50 MeV. PMID- 9966688 TI - Limits on neutron emission from "cold fusion" in metal hydrides. PMID- 9966687 TI - 0 degrees polarization transfer in H2(p-vector,n-vector)pp at 54 and 71 MeV. PMID- 9966690 TI - Self-consistent approximation to the solution of the Bethe-Salpeter equation. PMID- 9966689 TI - Measurements of the deuteron and proton magnetic form factors at large momentum transfers. PMID- 9966692 TI - 3He(e,e'p)2H breakup process. PMID- 9966691 TI - Theoretical analysis of two-body electrodisintegration of 3He. PMID- 9966693 TI - Kaon photoproduction: Data consistency, coupling constants, and polarization observables. PMID- 9966695 TI - Inclusive annihilation of antiprotons on deuterium. PMID- 9966694 TI - Analytical model for the triton asymptotic D-state parameters. PMID- 9966696 TI - Complex local potential by Marchenko inversion of partly real and partly complex phase shift. PMID- 9966698 TI - 9Be(t,p)11Be and the structure of 11Be. PMID- 9966697 TI - Anomalous signature-dependence of rotational bands in odd-A nuclei explained in terms of gamma vibration. PMID- 9966699 TI - Excited states in 140Sm above the ( pi h11/2)2 and ( nu h11/2)-2 10(+) isomers. PMID- 9966701 TI - Higher excitation levels of B11 via the B10(n,n)B10 and B10(n,n')B10* (0.72, 1.74, 2.15, 3.59, 4.77 MeV) reactions. PMID- 9966700 TI - Nuclear charge radii of the tin isotopes from muonic atoms. PMID- 9966702 TI - M1 and E2 strength functions of barium from thermal neutron capture. PMID- 9966704 TI - Microscopic calculation of K-bar atomic and Lambda * hypernuclear carbon. PMID- 9966703 TI - Odd-odd interacting-boson-approximation calculations: Experimental agreement for doubly decoupled and highly distorted bands in 176-180Re. PMID- 9966705 TI - Semiclassical description of the scissors mode: Possible improvements and intrinsic limitations. PMID- 9966707 TI - Shell model calculations for levels and transition rates in 204Pb and 206Pb. PMID- 9966706 TI - Instability of infinite nuclear matter in the relativistic Hartree approximation. PMID- 9966709 TI - Effective boson number calculations near the Z=64 subshell. PMID- 9966708 TI - Linearized Schrodinger equation for nuclear quadrupole surface vibrations. PMID- 9966711 TI - Cross sections of neon isotopes induced by 5, 7, 16, and 19 MeV neutrons. PMID- 9966710 TI - Self-consistent semiclassical sum rule approach and the properties of giant resonances. PMID- 9966712 TI - Quasifree knockout of charged particles from 4He with 100 MeV protons. PMID- 9966713 TI - Multifragment emission in reactions of 84Kr on Ag and Au at 17.7, 27, and 35 MeV/nucleon. PMID- 9966714 TI - Elastic and inelastic scattering of 36Ar on 208Pb at 575 MeV beam energy. PMID- 9966715 TI - Pre-scission 4He multiplicity in the 19F+197Au reaction. PMID- 9966717 TI - Excitation functions and isomeric cross-section ratios for the 90Zr(n,p)90Ym,g and 91Zr(n,p)91Ym,g processes. PMID- 9966716 TI - Effect of the entrance channel mass asymmetry on the limitation of light heavy ion fusion cross sections. PMID- 9966718 TI - Test of distorted wave kinematic coupling approximation calculations for knockout reactions. PMID- 9966719 TI - Accuracy of the Vlasov-Nordheim approximation in the classical limit. PMID- 9966720 TI - Quantum molecular dynamics study of fusion and its fade out in the 16O+16O system. PMID- 9966721 TI - Diffraction theory of scattering by rotating nuclei. PMID- 9966722 TI - Equivalence between deep energy-dependent and shallow angular-momentum-dependent potentials. PMID- 9966724 TI - Relativistic analysis of meson exchange currents in elastic electron-deuteron scattering. PMID- 9966723 TI - Asymmetry in inclusive polarized electron scattering from polarized nuclei: Sum rule approach. PMID- 9966726 TI - Measurement of inclusive 12C(e,p) cross sections. PMID- 9966725 TI - Neutron-triton cross sections and scattering lengths obtained from p-3He scattering. PMID- 9966727 TI - Determination of the absorption mechanism in photon-induced pre-equilibrium reactions. PMID- 9966729 TI - Cross section for the 27Al(p,2 pi +)28Mg reaction at 800 MeV. PMID- 9966728 TI - 4Lig.s. formation in the 3He+p+n reaction. PMID- 9966730 TI - Fragment mass and kinetic energy distributions for the photofission of 234U with 12-, 15-, and 20-MeV bremsstrahlung. PMID- 9966731 TI - Density dependent interaction applied to low-multipole (p,p') and (p,n) transitions in light nuclei. PMID- 9966733 TI - Comment on "Wave function of 14N" PMID- 9966732 TI - Rotational symmetry in the relativistic constituent quark model. PMID- 9966734 TI - Erratum: Operator expansion method and the double beta decay of 48Ca PMID- 9966735 TI - 2H(p,2p)n reaction at 508 MeV: Recoil momentum >200 MeV/c. PMID- 9966737 TI - Reaction 52Cr(p, gamma )53Mn from 1.38 to 1.66 MeV. PMID- 9966736 TI - Effects of short range Delta N interaction on observables of the pi NN system. PMID- 9966738 TI - Rotational band structures in doubly odd 138Pm. PMID- 9966739 TI - Structure of 4Li and 4He observed in the 1H( alpha,3He p)n reaction. PMID- 9966741 TI - Evidence for the contribution of 0f5/2,1p3/2 proton excitations in the low-lying states in 92,94Zr. PMID- 9966740 TI - Determination of 181Re and 181Os atomic masses from the 185Re( alpha,8He)181Re reaction. PMID- 9966742 TI - Reinvestigation of 56Ni decay. PMID- 9966743 TI - Lifetimes of the lowest 5/2(+) and 9/2(+) states in the mirror nuclei 23Na-23Mg. PMID- 9966744 TI - Some aspects of the 111Cd level scheme. PMID- 9966745 TI - Lifetime measurements in 75Kr and systematic study of krypton isotopes. PMID- 9966747 TI - Quantum extension of the Vlasov method. PMID- 9966746 TI - Electromagnetic form factors for an off-shell nucleon in a vector meson dominance model. PMID- 9966749 TI - Neutron hole strength distribution of the 2f7/2 state of 207Pb. PMID- 9966748 TI - Centroids of effective interactions from measured single-particle energies: An application. PMID- 9966750 TI - Validity of the adiabatic rotational model in the case of the hexadecupole operator. PMID- 9966752 TI - Role of nuclear densities in nucleon elastic scattering. PMID- 9966751 TI - Squeeze-out of nuclear matter as a function of projectile energy and mass. PMID- 9966753 TI - Comparison of Dirac and Schrodinger descriptions of spin observables for proton nucleus elastic scattering at 650 and 800 MeV. PMID- 9966754 TI - Rapid massive cluster formation. PMID- 9966755 TI - Systematics of alpha decay half-lives. PMID- 9966757 TI - Production of pionic atoms with the ( pi -, pi +) reaction. PMID- 9966756 TI - Calculations of complete fusion, incomplete fusion, and direct reaction cross sections for deuteron-induced reactions. PMID- 9966758 TI - Proton mean field in 40Ca between -60 MeV and +200 MeV deduced from a dispersive optical-model analysis. PMID- 9966759 TI - Transient behavior at deformations beyond saddle point and neutron multiplicity. PMID- 9966760 TI - Electric quadrupole excitations in relativistic nucleus-nucleus collisions. AB - Calculations are presented for electric quadrupole excitations in relativistic nucleus-nucleus collisions. The theoretical results are compared to an extensive data set and it is found that electric quadrupole effects provide substantial corrections to cross sections, especially for heavier nuclei. PMID- 9966761 TI - Relativistic effects in proton-antiproton annihilation into two mesons. PMID- 9966763 TI - Proton-neutron symmetry in valence mirror nuclei. PMID- 9966762 TI - Isospin symmetry in nucleon scattering from 6Li and 12C at 280 MeV. PMID- 9966764 TI - Production of 14,15O, 18F, and 19Ne radioactive nuclei from (p,n) reactions up to 30 MeV. PMID- 9966766 TI - Coulomb versus nuclear breakup in 11Li fragmentation. PMID- 9966765 TI - Low-energy reaction yields for 18O(p, gamma ) and 18O( alpha, gamma ). PMID- 9966767 TI - Non-octupole origin of the 51- state in 144Nd. PMID- 9966768 TI - 37Ca beta + decay and the efficiency of the 37Cl detector for high energy neutrinos. PMID- 9966769 TI - Energy dependence of cross section for charge pickup of relativistic heavy ions. PMID- 9966770 TI - Photoexcitation of low-lying dipole transitions in 236U. PMID- 9966771 TI - Radiative kaon capture on nuclei. PMID- 9966772 TI - Continuum analyzing power for 4He(p PMID- 9966773 TI - Absorptive model of kaon photoproduction. PMID- 9966774 TI - High spin core-excited isomers and octupole coupling in 213Rn. PMID- 9966775 TI - Applicability of truncation schemes in the cranked deformed shell model. PMID- 9966776 TI - Comment on "Monopole strength and shape coexistence in the A PMID- 9966777 TI - Reply to "Comment on 'Monopole strength and shape coexistence in the A PMID- 9966778 TI - Particle- gamma correlation determination of static quadrupole moments. PMID- 9966779 TI - Radiative kaon capture on deuterium and the Lambda n scattering lengths. PMID- 9966780 TI - Effects of nuclear deformation on 151,153Eu(p,n)151,153Gd reactions. PMID- 9966781 TI - Observation of narrow structures in the p-p elastic analyzing power. PMID- 9966782 TI - Nuclear polarization and magnetic resonance of unstable 170Tm with beta-ray radiation-detected optical pumping in solids. PMID- 9966783 TI - Onset of flow of charged fragments in Au-Au collisions. PMID- 9966785 TI - Additional evidence for the proposed excited state at <= 5 eV in 229Th. PMID- 9966784 TI - Possible cluster preformation in the 14C decay of 223Ra. PMID- 9966787 TI - Role of Levinson's theorem in neutron-deuteron quartet S-wave scattering. PMID- 9966786 TI - Fluctuation growth and spinodal decomposition in heavy ion reactions. PMID- 9966788 TI - Production of an isomeric, excited radioactive nuclear beam. PMID- 9966789 TI - Production of intense radioactive ion beams using two accelerators. PMID- 9966790 TI - 4He( pi, pi 'p)3H reaction: Quasifree and resonance scattering. PMID- 9966791 TI - Strong octupole and dipole collectivity in 96Zr: Indication for octupole instability in the A=100 mass region. PMID- 9966792 TI - Dissipative processes in light-heavy-ion-induced reactions and their time scales. PMID- 9966793 TI - Temperature dependence of fusion barriers. PMID- 9966794 TI - Contributions of l PMID- 9966795 TI - Bonn potential and electron-deuteron scattering at high momentum transfer. PMID- 9966796 TI - Radiative neutron capture on 3He. PMID- 9966798 TI - Relativistic treatment of the long wavelength limit for the photon and the multipole amplitudes of 2H( gamma,n)1H. PMID- 9966797 TI - Total cross section for the gamma d--> pi -pp reaction between 380 and 840 MeV. PMID- 9966799 TI - Effect of the nucleon-delta interaction on properties of the three-nucleon ground state. PMID- 9966800 TI - Linear relation between deuteron matter radius and the scattering length. PMID- 9966801 TI - Decay of 132Cs and nuclear structure of 132Xe. PMID- 9966802 TI - Rotational structures in 181,182,183Ir. PMID- 9966803 TI - Rotational band structures in 127Cs: Shape changes induced by h11/2 neutron alignment. PMID- 9966804 TI - Weak coupling in the odd-mass Xe nuclides: Decay of 6.2-h 127Cs to levels of odd neutron 127Xe. PMID- 9966805 TI - 17O(d PMID- 9966807 TI - Sub-barrier fusion of 37Cl with 58,60,62,64Ni. PMID- 9966806 TI - Gamow-Teller transition strengths from the 11B(p,n)11C reaction in the energy range 160-795 MeV. PMID- 9966808 TI - Structure of 76Zn from 76Cu decay and systematics of neutron-rich Zn nuclei. PMID- 9966810 TI - Kinetic approach to the damping of giant quadrupole resonances. PMID- 9966809 TI - Semiclassical simulation of finite nuclei. PMID- 9966812 TI - Nuclear shape coexistence in a schematic model. PMID- 9966811 TI - Exact effective potential for a scalar source coupled to the sine-Gordon model: Test of effective potentials for composite nucleons. PMID- 9966813 TI - Collective enhancement of nuclear level density in the interacting boson model. PMID- 9966815 TI - Superdeformed many-particle-many-hole states in N=Z nuclei: Beyond the 8p-8h state in 40Ca. PMID- 9966814 TI - Two- and four-quasiparticle states in the interacting boson model: Strong coupling and decoupled band patterns in the SU(3) limit. PMID- 9966816 TI - Search for photons from the decay of the delta resonance in heavy-ion collisions. PMID- 9966818 TI - Light fragments from 14N+Ag collisions at 35 MeV/nucleon. PMID- 9966817 TI - n+209Bi mean field between -20 and 60 MeV. PMID- 9966819 TI - Direct cluster transfer in 3He bombardment of 13C at sub-barrier energies. PMID- 9966821 TI - Cross section measurements of the pion single-charge-exchange reaction 12C( pi +, pi 0)12N(g.s.). PMID- 9966820 TI - Alpha-induced reactions on fissile nuclei at energies to 50 MeV. PMID- 9966822 TI - Inclusive neutron cross sections at forward angles from Nb-Nb and Au-Au collisions at 800 MeV/nucleon. PMID- 9966823 TI - Single-particle excitations in 89Y. PMID- 9966824 TI - Anomalous anisotropies of fission fragments for the 16O+232Th sub-barrier fusion fission reaction. PMID- 9966825 TI - Inverse reactions and the statistical evaporation model: Ingoing-wave boundary condition and optical models. PMID- 9966826 TI - Multistep compound nuclear reactions with giant resonances as doorway states. PMID- 9966827 TI - Description of heavy ion collisions including the cascading of secondaries. PMID- 9966828 TI - Measurement of the asymmetry parameter for 29P beta decay. PMID- 9966829 TI - Shell-model calculation for two-neutrino double beta decay of 48Ca. PMID- 9966831 TI - Identification of 186Au alpha activity. PMID- 9966830 TI - New nucleus 142Xe: Test of the NpNn scheme. PMID- 9966832 TI - Experiment to detect quark effects in nuclei. PMID- 9966833 TI - Comparison of Schrodinger and Dirac coupled-channels analyses of the 28Si(p,p')28Si reaction at 500 MeV. PMID- 9966834 TI - Canonicity condition in adiabatic time-dependent Hartree-Fock theory. PMID- 9966835 TI - Integral representation for off-shell Jost functions. PMID- 9966836 TI - Method for nonlocal optical model calculations. PMID- 9966837 TI - Comment on "testing" the Gamow-Teller sum rule. PMID- 9966838 TI - Reply to "Comment on 'testing' the Gamow-Teller sum rule" PMID- 9966839 TI - Comment on "Spin density and the real part of the heavy-ion potential" PMID- 9966840 TI - Erratum: Heat partition in the E/A=8.5 MeV 74Ge+165Ho reaction PMID- 9966841 TI - Erratum: Dipole strength function in 11Li PMID- 9966842 TI - Erratum: Microscopic calculation of bremsstrahlung emission in 3He+ alpha collisions PMID- 9966843 TI - 3H(p, gamma )4He reaction and the ( gamma,p)/( gamma,n) ratio in 4He. PMID- 9966844 TI - Decay of the neutron-rich isotope 171Ho and the identification of 169Dy. PMID- 9966845 TI - Identification of the pi g9/2 band in 67As. PMID- 9966846 TI - First observation of absorption of real photons by T=1 p-n pairs in the ( gamma,p) reaction. PMID- 9966847 TI - Octupole correlation effects in 151Pm. PMID- 9966848 TI - Pre-scission 1H and 4He emissions in 16O+197Au reaction. PMID- 9966850 TI - One-boson-exchange potential based on a soft pion form factor. PMID- 9966849 TI - Shape changes in N=Z nuclei from germanium to zirconium. PMID- 9966851 TI - Elastic-scattering angular distributions for 40Ca+48Ca near the Coulomb barrier. PMID- 9966852 TI - Isospin forbidden E1 transitions in 16O and 40Ca and the applicability of Siegert's theorem. PMID- 9966853 TI - Annihilation shifts and widths of the p-bar-d atomic levels. PMID- 9966855 TI - Two-deuteron radiative capture: Polarization observables at Ed <= 15 MeV. PMID- 9966854 TI - n-p mass difference and charge-symmetry breaking in the trinucleons. PMID- 9966856 TI - Relativistic potential model of proton-proton scattering spin observables. PMID- 9966857 TI - Magnetic moment interaction in nucleon-nucleon phase-shift analyses. PMID- 9966858 TI - Triton asymptotic normalization constants by the hyperspherical harmonics expansion method. PMID- 9966860 TI - New "Octupole-driving particle numbers" from examination of 31- state energies. PMID- 9966859 TI - Shape coexistence and octupole vibrations in 74Se. PMID- 9966861 TI - Transitional nuclei in the rare-earth region: Energy levels and structure of 130,132Ce, 132,134Nd, and 134Pm, via beta decay of 130,132Pr, 132,134Pm, and 134Sm. PMID- 9966862 TI - Spectroscopy of positive parity states in 26Mg and 26Al via the ( alpha,3He) and ( alpha,t) reactions. PMID- 9966863 TI - Two-proton transfer reactions on even Ni and Zn isotopes. PMID- 9966865 TI - Finite temperature random phase approximation with the inclusion of scattering terms. PMID- 9966864 TI - Level structures of 119Te and 121Te populated in the decay of 119I and 121I. PMID- 9966867 TI - Particle-hole symmetry and meson exchange corrections to the 6He beta decay amplitude. PMID- 9966866 TI - Translationally invariant coupled cluster theory for simple finite systems. PMID- 9966868 TI - Band structure in 95Ru. PMID- 9966869 TI - Systematic dependence of the gamma -g B(E2) ratios on the NpNn product. PMID- 9966870 TI - Scissor mode applied to the yrast band of the rare-earth nuclei. PMID- 9966871 TI - Coriolis attenuation in the A PMID- 9966873 TI - Microscopic interpretation of inelastic electron scattering from even Ni isotopes. PMID- 9966872 TI - Further evaluation of the fitted Nilsson parameters in the A PMID- 9966874 TI - Effects of isoscalar admixtures on the combined analysis of electron-nucleus and proton-nucleus "scissors mode" excitations in the f-p shell. PMID- 9966875 TI - Nuclear equation of state with derivative scalar coupling. PMID- 9966876 TI - Model of a superconducting phase transition. PMID- 9966877 TI - Competition between alpha clustering and the spin-orbit force in the ground bands of 8Be, 20Ne, and 44Ti. PMID- 9966878 TI - Dynamics of band crossings in the yrast bands of 184Pt and 186Pt. PMID- 9966879 TI - Test of the adequacy of using smoothly joined parabolic segments to parametrize the multihumped fission barriers in actinides. PMID- 9966881 TI - Magnetic dipole strength functions in heavy deformed nuclei. PMID- 9966880 TI - Extension of multiphonon theory to odd-mass nuclei. PMID- 9966882 TI - Decay of 156Er compound nucleus. PMID- 9966883 TI - Electron-capture-delayed fission properties of 232Am. PMID- 9966884 TI - Charge and mass distributions in strongly damped reactions of 58Ni+165Ho at 16 MeV/nucleon. PMID- 9966886 TI - Very-high-energy light charged-particle production near 0 degrees in heavy-ion collisions, 9 <= E/A <= 40 MeV. PMID- 9966885 TI - Systematics of pion absorption on 6Li. PMID- 9966888 TI - Activation cross section and isomeric cross-section ratio for the 46Ti(n,p)46Scm,g process. PMID- 9966887 TI - Sub-barrier fusion and elastic scattering in S+Ni systems. PMID- 9966889 TI - Barium and xenon isotope yields in photopion reactions of 133Cs. PMID- 9966890 TI - Proton emission cross sections of silicon isotopes. PMID- 9966891 TI - Multiparticle interactions in backward proton production, subthreshold antiproton production, and inclusive electron scattering from nuclei. PMID- 9966892 TI - Conservation laws and nuclear transport models. PMID- 9966893 TI - K-matrix analysis of resonance nuclear reactions. PMID- 9966894 TI - Comparison of relativistic and nonrelativistic approaches to the collective model treatment of p+40Ca inelastic scattering. PMID- 9966895 TI - Cascade statistical model for nucleon-induced reactions on light nuclei in the energy range 50 MeV-1 GeV. PMID- 9966896 TI - Validity of on-shell distortion factors for NN--> pi d. PMID- 9966897 TI - Schematic model for nuclear molecules as doorway states for fusion. PMID- 9966899 TI - Tensor interaction effects in the 4He(2H, gamma )6Li capture reaction. PMID- 9966898 TI - Branching ratios in low-energy deuteron-induced reactions. PMID- 9966900 TI - Gamma-ray emission from multistep compound reactions. PMID- 9966901 TI - Quark cluster model for deep-inelastic lepton-deuteron scattering. PMID- 9966902 TI - Covariant multiple scattering series for elastic projectile-target scattering. PMID- 9966904 TI - Tests of fundamental symmetries on isolated compound-nucleus resonances. PMID- 9966903 TI - Weak interaction processes on deuterium: Muon capture and neutrino reactions. PMID- 9966905 TI - Measurements of keV neutron capture cross sections with a 4 pi barium fluoride detector: Examples of 93Nb, 103Rh, and 181Ta. PMID- 9966907 TI - Target fragment mass distribution for the reaction of 13.3 GeV/nucleon 28Si with 197Au. PMID- 9966906 TI - Analyzing power measurements in pn--> pi -pp(1S0). PMID- 9966908 TI - Mean free paths of multiple helium fragments produced by 32S at 6.4 TeV. PMID- 9966910 TI - Deuteron photodisintegration and quark models. PMID- 9966909 TI - Determination of the impact parameter in relativistic nucleus-nucleus collisions. PMID- 9966911 TI - Semistatistical model for 12C+12C reaction cross sections below the Coulomb barrier. PMID- 9966912 TI - Inclusion of temperature dependence of fission barriers in statistical model calculations. PMID- 9966913 TI - Single nucleon emission in relativistic nucleus-nucleus reactions. AB - Significant discrepancies between theory and experiment have previously been noted for nucleon emission via electromagnetic processes in relativistic nucleus nucleus collisions. The present work investigates the hypothesis that these discrepancies have arisen due to uncertainties about how to deduce the experimental electromagnetic cross section from the total measured cross section. An optical-model calculation of single neutron removal is added to electromagnetic cross sections and compared to the total experimental cross sections. Good agreement is found thereby resolving some of the earlier noted discrepancies. A detailed comparison to the recent work of Benesh, Cook, and Vary is made for both the impact parameter and the nuclear cross section. Good agreement is obtained giving an independent confirmation of the parametrized formulas developed by those authors. PMID- 9966914 TI - Effect of quark antisymmetrization on the binding energy of nuclear matter. PMID- 9966917 TI - High-energy gamma emission in heavy-ion collisions at 9-14 MeV/nucleon. PMID- 9966916 TI - Decay studies of the neutron-rich isotopes 168Dy and 168Hog and the identification of the new isomer 168Hom. PMID- 9966915 TI - Erratum: Nonrelativistic full-folding model of nucleon elastic scattering at intermediate energies PMID- 9966918 TI - Lifetime measurements in 135Sm: Large deformation in the N=6 intruder band and evidence for quenched proton pairing. PMID- 9966919 TI - Energy and flux limits of cold-fusion neutrons using a deuterated liquid scintillator. PMID- 9966920 TI - Resonant excitation of the reaction 180Tam( gamma, gamma ')180Ta. PMID- 9966921 TI - Observation of excited proton and neutron configurations in the superdeformed 149Gd nucleus. PMID- 9966922 TI - Coupling schemes in doubly odd nuclei and identical superdeformed bands. PMID- 9966923 TI - Relativistic off-shell analysis of elastic scattering of 200 MeV protons by 40Ca. PMID- 9966924 TI - Nuclear level densities including thermal and quantal fluctuations. PMID- 9966925 TI - Shadowing effects in deep-inelastic lepton-nucleus scattering. PMID- 9966926 TI - Benchmark solutions for a model three-nucleon scattering problem. PMID- 9966927 TI - Comparison of the vector analyzing power iT11 for pi +/-d scattering at 180 MeV. PMID- 9966928 TI - Kinematically complete measurement of the pi +d--> pi 0pp charge-exchange reaction. PMID- 9966930 TI - Pion photoproduction resonance couplings in the second resonance region. PMID- 9966931 TI - rms radius of the deuteron. PMID- 9966929 TI - Partial-wave analysis of pion photoproduction. PMID- 9966932 TI - Parity violating nuclear force by meson mixing. PMID- 9966933 TI - Meson retardation, three-body forces, and medium modifications to the nucleon nucleon interaction. PMID- 9966934 TI - Determination of the S-wave scattering shape parameter P from the zero-energy wave function. PMID- 9966935 TI - Microscopic study of p+ alpha bremsstrahlung. PMID- 9966936 TI - Deuteron structure from (p,2p) and (d,p) breakup data at medium energies. PMID- 9966937 TI - Optical isotope shift and hyperfine structure measurements of 152,154-158,160Gd. PMID- 9966938 TI - Determination of 187Ir atomic mass by the 187Os(3He,t)187Ir reaction. PMID- 9966939 TI - Search for ground state proton emission from 65As and 69Br. PMID- 9966941 TI - Existence of alpha -cluster structure in 44Ti via the (6Li,d) reaction. PMID- 9966940 TI - Pion double charge exchange on T=2 nuclei in the Delta 3/2,3/2 resonance region. PMID- 9966942 TI - Uncommon decay branching ratios of spin-one states in the rare-earth region and evidence for K mixing. PMID- 9966943 TI - Proton core polarization in low-lying states of 86Sr. PMID- 9966944 TI - Coulomb excitation of 159Tb and the spectroscopy of the proton 3/2(+) PMID- 9966945 TI - Decay of 133Pr and structure of 133Ce. PMID- 9966947 TI - Relativistic nuclear structure. II. Finite nuclei. PMID- 9966946 TI - Relativistic nuclear structure. I. Nuclear matter. PMID- 9966949 TI - Fragmentation of the low energy octupole state and the systematic behavior of 31- states. PMID- 9966948 TI - Electromagnetic probes of nuclear structure: Sum rules, y scaling, and final state interactions. PMID- 9966950 TI - Relativistic spectral random-phase approximation in finite nuclei. PMID- 9966951 TI - Angular momentum projection in geometric interpretation of the interacting boson model. PMID- 9966952 TI - Fermion mapping of boson-fermion pairs. PMID- 9966953 TI - Consistent description of intruder states. PMID- 9966954 TI - Saturation in weakly coupled relativistic systems. PMID- 9966955 TI - p-shell nuclei in a (0+2) PMID- 9966956 TI - p-shell nuclei in a (0+2) PMID- 9966958 TI - Green's function derivation of the thermal random phase approximation equations in open shell systems. PMID- 9966959 TI - Angular momentum in sub-barrier fusion: Experimental study using the isomer ratio 137Cem/137Ceg. PMID- 9966957 TI - Multichannel approach to the Glauber model for heavy-ion collisions. PMID- 9966960 TI - Dynamical effects on the de-excitation of hot nuclei with A PMID- 9966962 TI - Photofission of 238U with monochromatic gamma rays in the energy range 11-16 MeV. PMID- 9966961 TI - Spectral function of p-n pairs in 6Li, from the 6Li(p,p alpha )pn reaction at 200 MeV. PMID- 9966963 TI - Extended sum-rule model view of light and intermediate mass fragment emission in nuclear reactions at intermediate energies. PMID- 9966964 TI - Hard photon emission in heavy-ion reactions. PMID- 9966965 TI - Polarized electron scattering from oriented nuclei in distorted-wave method. PMID- 9966966 TI - Elastic Coulomb scattering of heavy ions at intermediate energies. PMID- 9966968 TI - Effective hadron theories from a quark model in U(1) and SU(N) color. PMID- 9966967 TI - Dependence of physical observables on the incident energy in intermediate energy nucleus-nucleus collision. PMID- 9966969 TI - Neutron-proton mass difference in nuclei and the Okamoto-Nolen-Schiffer anomaly ly. PMID- 9966971 TI - Contribution of pi N--> Lambda K to subthreshold kaon production in heavy-ion collisions. PMID- 9966972 TI - Isospin in 17O( gamma,n0) reactions. PMID- 9966970 TI - Pion scattering from polarized 15N at T pi =164 MeV. PMID- 9966973 TI - Nuclear refraction in 14N+12C elastic scattering at E/A=20 MeV. PMID- 9966974 TI - Fission angular distributions for the systems 9Be+232Th, 235U. PMID- 9966975 TI - Nuclear tensor term in the relativistic impulse approximation for proton-nucleus elastic scattering. PMID- 9966976 TI - Gauge-invariant forms of the nonrelativistic Compton amplitude. PMID- 9966977 TI - Soft giant dipole mode of 11Li. PMID- 9966978 TI - Microscopic calculations of low-energy reaction cross sections. PMID- 9966979 TI - pi NN coupling, the pi N N- form factor, and the Goldberger-Treiman discrepancy. PMID- 9966981 TI - Spins in superdeformed bands in the mass 190 region. PMID- 9966980 TI - Charge dependence and electric quadrupole effects on single-nucleon removal in relativistic and intermediate energy nuclear collisions. AB - Single-nucleon removal in relativistic and intermediate energy nucleus-nucleus collisions is studied using a generalization of Weizsacker-Williams theory that treats each electromagnetic multipole separately. Calculations are presented for electric dipole and quadrupole excitations and incorporate a realistic minimum impact parameter, Coulomb recoil corrections, and the uncertainties in the input photonuclear data. Discrepancies are discussed. The maximum quadrupole effect to be observed in future experiments is estimated and also an analysis of the charge dependence of the electromagnetic cross sections down to energies as low as 100 MeV/nucleon is made. PMID- 9966983 TI - Light-front Hamiltonian dynamics of proton-deuteron scattering. PMID- 9966982 TI - Phenomenological Delta -nucleus potential from inclusive electron-nucleus scattering data. PMID- 9966986 TI - Integrodifferential equation approach. I. Triton and alpha -particle binding energies. PMID- 9966985 TI - Does it make sense to talk about N Delta phase shifts? PMID- 9966984 TI - Neutron polarization in polarized 3He targets. PMID- 9966987 TI - N Delta interaction in pi d breakup. PMID- 9966988 TI - Quasielastic electron scattering on a two-nucleon model system: Scaling and cumulant expansion of the structure function. PMID- 9966990 TI - Nuclear spin response of 40Ca to 800 MeV polarized protons. PMID- 9966989 TI - Elastic magnetic electron scattering from 41Ca. PMID- 9966991 TI - Survey of the ( alpha,2He) reaction on fp-shell nuclei. PMID- 9966992 TI - Isospin character of the "isoscalar" giant quadrupole resonance in 118Sn. PMID- 9966993 TI - Transition strengths and deformation in 77Kr. PMID- 9966994 TI - Lifetimes of yrast J pi =16(+)-26(+) states in 130Ce. PMID- 9966996 TI - Nuclear ground-state correlations in the relativistic random-phase approximation. PMID- 9966998 TI - Pion-nucleus single-charge exchange above the resonance. PMID- 9966999 TI - Analytic formula for quadrupole-quadrupole matrix elements. PMID- 9966997 TI - Coulomb energy of a proton in the relativistic nuclear shell model. PMID- 9967000 TI - Multi-lambda hypernuclei and the equation of state of hypermatter. PMID- 9966995 TI - Structure and decay modes of antisymmetric beta vibrations in the O(6) limit of the neutron-proton interacting boson model. PMID- 9967001 TI - Core polarization effects on spin-dipole and first-forbidden beta -decay operators in the lead region. PMID- 9967002 TI - Neutron scattering from elemental indium: Optical model and bound-state potential. PMID- 9967003 TI - Systematic behavior of one- and two-nucleon transfer reactions induced by medium weight projectiles. PMID- 9967005 TI - Determination of the cross sections for the production of fragments from relativistic nucleus-nucleus interactions. II. Parametric fits. PMID- 9967004 TI - Determination of the cross sections for the production of fragments from relativistic nucleus-nucleus interactions. I. Measurements. PMID- 9967006 TI - Target fragmentation of Au and Th by 2.6 GeV protons. PMID- 9967008 TI - Nonlocal couplings, off-shell effects, and the nuclear response. PMID- 9967007 TI - Enhancement of the near-side component in quasiadiabatic calculations of the 66Zn(d,p)67Zn reaction. PMID- 9967009 TI - Photoproduction of eta mesons from nuclei. PMID- 9967011 TI - Two-step processes and short-range correlations in the reaction 12C( gamma,p). PMID- 9967010 TI - Nucleus- Sigma potential. PMID- 9967013 TI - Saturation and nucleation in hot nuclear systems. PMID- 9967012 TI - Approximate treatment of the continuum. PMID- 9967014 TI - Multistep alpha-transfer and parity dependence in large angle scattering. PMID- 9967015 TI - Angular correlation of electrons and positrons in internal pair conversion. PMID- 9967017 TI - y scaling in the relativistic region. PMID- 9967018 TI - Contribution of meson exchange currents to pion double charge exchange at low energies. PMID- 9967019 TI - Quark shell model of nuclei and nuclear magnetic moments. PMID- 9967016 TI - Detailed predictions for two-pion correlations in ultrarelativistic heavy-ion collisions. PMID- 9967020 TI - Modified loop expansion for nuclear matter in a chiral model. PMID- 9967021 TI - Constituent quark model of the nucleon-nucleon interaction. PMID- 9967022 TI - Application of the constituent quark nucleon-nucleon interaction to the deuteron. PMID- 9967024 TI - Measurement of the half-life of 56Co. PMID- 9967023 TI - Phenomenological structure of the weak Lambda N-->NN interaction and the Delta I=1/2 rule. PMID- 9967025 TI - 22Ne(d,p)23Ne reaction and neutron balance in the s process. PMID- 9967026 TI - Intruder states in odd-mass Ag isotopes. PMID- 9967028 TI - Effect of high momenta on low energy scattering. PMID- 9967029 TI - Energy dependence of the nuclear level density at energies above 100 MeV. PMID- 9967027 TI - 116Sn from 116Cd( alpha,4n gamma ) reaction. PMID- 9967030 TI - Application of Vlasov approach to the soft giant dipole resonance in nucleus 11Li. PMID- 9967031 TI - Test of the coupled channels model for sub-barrier fusion reactions. PMID- 9967035 TI - y scaling as a probe of nuclear light-cone dynamics. PMID- 9967032 TI - Erratum: Systematics of nuclear ground state properties in 78-100Sr by laser spectroscopy PMID- 9967033 TI - First measurement of B(E2) values from sigma 3 alpha. PMID- 9967062 TI - Measurement of spin observables in the 28Si(p PMID- 9967063 TI - Isovector giant quadrupole resonance observed in 30Si(p PMID- 9967064 TI - Nuclear response in the 54Fe(p PMID- 9967065 TI - Mass dependence of positive pion-induced fission. PMID- 9967066 TI - Equivalent Hamiltonians with additional discrete states. PMID- 9967067 TI - Systematic analysis of average angular momenta and cross sections in sub-barrier fusion. PMID- 9967068 TI - Reaction-mechanism study of the exclusive (p, Delta ++) process in nuclei. PMID- 9967069 TI - Charge-exchange effects in elastic scattering with radioactive beams. PMID- 9967071 TI - Absorption versus breakup in heavy-ion reactions. PMID- 9967072 TI - Dynamical model for heavy ion collisions with a single resonance. PMID- 9967074 TI - Semiclassical model for single-particle transitions in nucleus-nucleus interactions. PMID- 9967073 TI - Spin density contribution in heavy-ion interaction potentials using energy density formalism. PMID- 9967070 TI - Angular momentum and incident-energy dependence of nucleus-nucleus interaction. PMID- 9967076 TI - Ground-state widths of 5He and 5Li determined in the 3H(d, gamma )5He and the 3He(d, gamma )5Li reactions. PMID- 9967075 TI - Meson exchange current effects on magnetic dipole moments of p-shell nuclei. PMID- 9967077 TI - 11B(7Li,t) and the (p, pi +) reaction. PMID- 9967078 TI - Observation of a minimum in collective flow for Ar+V collisions. PMID- 9967079 TI - Isospin and deformation splittings of the giant dipole resonance for triaxial nuclei. PMID- 9967080 TI - In-medium proton-neutron mass difference and the systematics of the Nolen Schiffer anomaly. PMID- 9967081 TI - Erratum: Relativistic multipole operators for semileptonic weak and electromagnetic nuclear reactions PMID- 9967083 TI - Reaction cross sections in the four-nucleon system with the multiconfiguration resonating-group method. PMID- 9967084 TI - Case for quasinuclear N-barN bound states. PMID- 9967082 TI - Two-neutron pairing enhancement factors. PMID- 9967085 TI - Nucleon-nucleon bremsstrahlung at intermediate energies. PMID- 9967086 TI - Nonlocality and the radius of the deuteron. PMID- 9967088 TI - Threshold electrodisintegration and electromagnetic form factors of the deuteron. PMID- 9967089 TI - Crossing and duality consistent study of Lambda, Sigma 0, and Lambda (1405) production by kaon photoproduction and radiative capture. PMID- 9967087 TI - Kinematic factors in the theory of y scaling. PMID- 9967091 TI - Double K-shell vacancy production in the electron capture decay of 139Ce. PMID- 9967090 TI - Observation of spin-aligned secondary fragment beams of 14B. PMID- 9967092 TI - Deformation and signature splitting in 74Br. PMID- 9967093 TI - Shape coexistence in 190Hg. PMID- 9967095 TI - Total cross section and neutron resonance spectroscopy for n+40Ar. PMID- 9967094 TI - 18O( gamma,pn+np) cross section. PMID- 9967096 TI - Isospin forbidden ( alpha,d) transitions to the low-lying states in 26Al. PMID- 9967098 TI - Nearly complete level scheme of 116Sn below 4.3 MeV. PMID- 9967097 TI - Quadrupole moments of high spin isomers in 213Fr, 212Fr, and 211Fr. PMID- 9967099 TI - Low-lying collective quadrupole and octupole strengths in even-even nuclei. PMID- 9967100 TI - Many-body correlation effects on the longitudinal response in the quasielastic (e,e') reaction. PMID- 9967102 TI - Appraisal of the Kuo-Herling shell-model interaction and application to A=210-212 nuclei. PMID- 9967101 TI - Variation of pairing correlations caused by nuclear rotation. PMID- 9967103 TI - Relativistic many-body theory of finite nuclei and the Schwinger-Dyson formalism. PMID- 9967104 TI - Calculation of yrast spectra in the doubly even cadmium isotopes. PMID- 9967105 TI - Distribution of spin dipole transition strength in the 15N(n,p)15C reaction. PMID- 9967107 TI - Determination of the nuclear level density at high excitation energy. PMID- 9967106 TI - Yield decomposition and excitation energy reconstruction in an incomplete fusion reaction. PMID- 9967112 TI - Mass, shell, and even-odd effects in radiative capture reaction. PMID- 9967108 TI - Preequilibrium proton emission induced by 80 and 120 MeV protons incident on 90Zr. PMID- 9967109 TI - Fusion cross sections for 12C+128Te and the deduction of absolute average angular momenta. PMID- 9967110 TI - Continuum protons from 58Ni(p,p') at incident energies between 100 and 200 MeV. PMID- 9967111 TI - Spin distribution of the compound nucleus formed by 16O+154Sm. PMID- 9967113 TI - Time scales for binary fragmentations of highly excited, fissile nuclei from 32S+197Au, 232Th. PMID- 9967114 TI - Excitation and multiple dissociation of 12C, 14N, and 16O projectiles in peripheral collisions at 32.5 MeV/nucleon. PMID- 9967116 TI - Scattering of 6He from 197Au, natTi, 27Al, natC, and 9Be at E=8-9 MeV. PMID- 9967115 TI - Measurement of the vector analyzing power iT11 in pi +-6Li PMID- 9967118 TI - Coulomb-dominated low-energy deuteron stripping. PMID- 9967119 TI - Electromagnetic production of polarization in hypernuclei. PMID- 9967117 TI - Pion double charge exchange on 42,44,48Ca for 300 <= T pi <= 550 MeV. PMID- 9967120 TI - Space-time evolution of nuclear reactions probed by two-proton intensity interferometry. PMID- 9967122 TI - Formal differences in perturbation methods for direct rearrangement collision processes. PMID- 9967123 TI - Coulomb correction to elastic alpha - alpha scattering. PMID- 9967121 TI - Implications of various spin-one relativistic wave equations for intermediate energy deuteron-nucleus scattering. PMID- 9967124 TI - Energy-dependent phase-shift analysis of 2H+4He scattering in the energy range 0.87 giant dipole resonance in light nuclei. PMID- 9967155 TI - Neutron hole states in 89Zr via the (p PMID- 9967156 TI - Dynamical symmetry breaking and mean-field chaotic motions in nuclear many-body systems. PMID- 9967157 TI - Rainbow-shift mechanism behind discrete optical-potential ambiguities. PMID- 9967158 TI - y-scaling analysis of quasielastic electron scattering and nucleon momentum distributions in few-body systems, complex nuclei, and nuclear matter. PMID- 9967159 TI - Collective boson realization for the nuclear Sp(6) model. PMID- 9967160 TI - Hexadecapole systematics in the interacting boson model. PMID- 9967161 TI - Signature of cluster substructure: alpha +d spectroscopic factor of 6Li. PMID- 9967162 TI - Perturbative analysis of the energy-weighted sum rule of bilinear fermion operators. PMID- 9967164 TI - Microscopic aspects of the pairing rotation and pairing vibration. PMID- 9967163 TI - Microscopic aspects of the Bohr-Mottelson model. PMID- 9967165 TI - Microscopic aspects of the interacting boson model. PMID- 9967166 TI - Photoexcitation of nuclear isomers by ( gamma, gamma ') reactions. PMID- 9967167 TI - Effective interaction for 16O(p,p') at Ep=318 MeV. PMID- 9967168 TI - Trends in fragment heating in the damped reaction 165Ho+56Fe at 7.2 MeV/nucleon. PMID- 9967169 TI - Upper limits on emission of neutrons from Ti in pressurized D2 gas cells: A test of evidence for "cold fusion" PMID- 9967170 TI - Average reaction cross sections for 74- to 112-MeV alpha particles on 127I and 133Cs. PMID- 9967172 TI - Multinucleon-transfer reactions for the 50Ti+93Nb system at sub- and near-barrier energies. PMID- 9967171 TI - Pion-induced double charge exchange on 12C, 24Mg, 32S, and 40Ca. PMID- 9967173 TI - Interaction of 8-46 MeV/nucleon 20Ne with Cu. PMID- 9967174 TI - Interpretation of ion-range recoil data obtained from activated-foil measurements of nuclear excitation functions. PMID- 9967175 TI - Resolution of the twofold ambiguity in the E1 capture amplitudes for the 13C(p PMID- 9967176 TI - Nuclear matter Ward identity and the theory of final-state interactions in inclusive and exclusive reactions. PMID- 9967178 TI - Relativistic proton-nucleus scattering and one-boson-exchange models. PMID- 9967177 TI - Optical model description of momentum transfer in relativistic heavy ion collisions. AB - An optical model description of momentum transfer in relativistic heavy ion collisions, based upon composite particle multiple-scattering theory, is presented. The imaginary component of the complex momentum transfer, which comes from the absorptive part of the optical potential, is shown to be the main contributor to the momentum loss of the projectile. Within the context of the Goldhaber formalism, predictions of fragment momentum distribution observables are made and compared with experimental data. Use of the model as a tool for estimating collision impact parameters is also discussed. PMID- 9967179 TI - Analysis of low energy pi + scattering to second O+ states. PMID- 9967180 TI - Analysis of the optical potential with coupled-channel scattering equations: Energy dependence and coordinate-space behavior. PMID- 9967182 TI - Heavy-ion transverse energy production at 14.5 GeV/nucleon: Single or multiple scattering? PMID- 9967181 TI - Diffractive excitation of 14.6-, 60-, and 200-GeV/nucleon 16O and 14.6 GeV/nucleon 28Si nuclei in nuclear emulsion. PMID- 9967183 TI - Radiative muon capture on carbon, oxygen, and calcium. PMID- 9967184 TI - Ordinary and radiative muon capture on 14N. PMID- 9967185 TI - Quasifree 12C( pi +,p) reaction and the pi N amplitude in nuclei. PMID- 9967186 TI - Pion double-charge-exchange reaction on 44Ca at 50 MeV. PMID- 9967187 TI - Lifetime measurement of the 21+ state in 152Nd and the B(E2;01+-->21+) systematics of the A PMID- 9967188 TI - Fission fragment angular distributions for the system 19F+232Th. PMID- 9967189 TI - Role of single-particle spectrum in the ring-diagram approach for nuclear matter. PMID- 9967191 TI - Interpretation of the fine structure in the 14C radioactive decay of 223Ra. PMID- 9967190 TI - Measuring the strangeness radius of the proton. PMID- 9967193 TI - Persistent success of the orbiting cluster model of heavy-ion resonances. PMID- 9967192 TI - Reaction calculations for 17O+12C including fusion within the molecular particle core model. PMID- 9967194 TI - beta + decays of very proton-rich sd-shell nuclei. PMID- 9967195 TI - Intermediate mass fragments emission in binary fragmentation model. PMID- 9967196 TI - Erratum: Polarization observables in deuteron photodisintegration and electrodisintegration PMID- 9967199 TI - Soft-photon analysis of pion-proton bremsstrahlung and the "experimental" magnetic moment of Delta ++(1232). PMID- 9967198 TI - Intruder bands as F-spin analog states. PMID- 9967197 TI - Observation of simultaneous g9/2 proton and neutron alignment in 74Kr. PMID- 9967200 TI - Unitarity consideration of pion production in relativistic heavy-ion collisions. PMID- 9967201 TI - How coherently do nuclei react to intense fields? PMID- 9967202 TI - Relativistic Hartree-Fock calculation of deformed nuclei. PMID- 9967203 TI - Physics of high-spin states in nuclei. PMID- 9967204 TI - Strong correlation and saturation of E2 and M1 transition strengths in even-even rare-earth nuclei. PMID- 9967205 TI - Successive energy ratios in medium- and heavy-mass nuclei as indicators of different kinds of collectivity. PMID- 9967206 TI - Coherent photon scattering cross sections for helium near the delta resonance. PMID- 9967207 TI - Vector and tensor spin observables in the reaction 1H PMID- 9967208 TI - Multinucleon pion absorption in the 4He( pi +,ppp)n reaction. PMID- 9967209 TI - Study of the systematic behavior of beta 2 values with the P-factor. PMID- 9967210 TI - Correlation between the elastic NN phase and the inelastic analyzing power. PMID- 9967211 TI - Higgs boson production in 0(+) 0(+) nuclear transitions. PMID- 9967212 TI - Variational calculations of few-body nuclei. PMID- 9967213 TI - Finite-temperature mean-field and higher-order approaches in canonical ensembles. PMID- 9967214 TI - Isospin effects in antinucleon-nucleon scattering and annihilation. PMID- 9967216 TI - Spectroscopy of 214Bi and systematics of 210,212,214Pb(0(+)) long-> beta 210,212,214Bi(0(-)). PMID- 9967215 TI - Isobaric-analog-state transitions in the (p,n) reaction at 135 MeV and density dependent impulse-approximation calculations. PMID- 9967217 TI - Double K-shell ionization in the electron capture decay of 55Fe. PMID- 9967218 TI - Scattering of polarized protons from 7Li at 200 MeV. PMID- 9967219 TI - Use of the (e,e'n) reaction to study the giant multipole resonances in 116Sn. PMID- 9967220 TI - Onset of neutron single-particle strengths in the tin isotopic chain. PMID- 9967221 TI - E0 transitions and O+ levels in 136Xe. PMID- 9967222 TI - Finite velocity meson exchange in nuclei. PMID- 9967223 TI - Reformulation of the variable moment of inertia model in terms of nuclear softness. PMID- 9967224 TI - Broken pair approach to rotating nuclei: Formalism. PMID- 9967225 TI - Electron scattering from 9Be. PMID- 9967226 TI - Structure of 9Be from proton scattering at 180 MeV. PMID- 9967227 TI - 13C(p,n)13N reaction to the 3/2(-) T=3/2 state at 15.06 MeV. PMID- 9967228 TI - High-statistics study of cluster radioactivity from 233U. PMID- 9967230 TI - Measurement of 6Li( gamma, pi +)6Heg.s. at 200 MeV. PMID- 9967229 TI - Spin alignment and density matrix measurement in 28Si+12C orbiting reaction. PMID- 9967231 TI - Spectroscopic tool for proton-rich nuclei: The (3He,6He) reaction. PMID- 9967232 TI - Neutron-induced fission cross section of 232Th from 1 eV to 20 keV. PMID- 9967233 TI - Measurement of the long-lived 26Al production cross section in the 27Al(n,2n) reaction. PMID- 9967234 TI - Angle and energy dependence of the superratio for pi + and pi - elastic scattering from H3 and He3: Evidence for charge-symmetry violation. PMID- 9967235 TI - Prompt gamma-ray multiplicity distributions in spontaneous fission of 252Cf. PMID- 9967237 TI - Elastic scattering of alpha particles from 209Bi at 24.8, 28.5, 34.7, 38.8, and 69.5 MeV. PMID- 9967236 TI - Neutron production from thick targets bombarded by alpha particles: Experiment and theoretical analysis of neutron energy spectra. PMID- 9967238 TI - Comparison of nucleon-nucleon potential models in a full-folding description of elastic scattering. PMID- 9967239 TI - Kaon production from hot and dense matter formed in heavy-ion collisions. PMID- 9967240 TI - Relativistic kinetic equations with mesonic degrees of freedom. PMID- 9967242 TI - Production of pionic atoms with the (e,e') reaction. PMID- 9967241 TI - pi -40Ca elastic scattering. PMID- 9967243 TI - Pion scattering from 39K and 58Ni. PMID- 9967244 TI - Z diagrams of composite objects. PMID- 9967246 TI - Nuclear medium modification of nucleons via a Bethe ansatz model. PMID- 9967245 TI - Nucleon self-energy in relativistic nuclear matter with pion ring series. PMID- 9967247 TI - Angular momentum projection with quantum effects. PMID- 9967248 TI - Nuclear dilepton production of Drell-Yan process in the constituent quark model. PMID- 9967249 TI - Neutron capture cross sections of 86Sr and 87Sr from 100 eV to 1 MeV, the conditions for the astrophysical s process, and the 87Rb-87Sr cosmochronometer. PMID- 9967250 TI - The "missing" 3(+) state of 18Ne and explosive 17F(p, gamma ) burning. PMID- 9967251 TI - Erratum: Multi-lambda hypernuclei and the equation of state of hypermatter PMID- 9967252 TI - Dilepton production at intermediate-energy heavy-ion collisions. PMID- 9967253 TI - Sources of light particles in peripheral collisions. PMID- 9967254 TI - Comparison of the double giant-dipole states observed in ( pi -, pi +) and ( pi +, pi -) reactions on 40Ca and 27Al. PMID- 9967255 TI - Diproton decay of nuclei on the proton drip line. PMID- 9967256 TI - Weighted particle method for solving the Boltzmann equation. PMID- 9967257 TI - Enhancement in interactions involving two steps. PMID- 9967258 TI - Absolute measurement of the differential cross section for the reaction 4He( gamma,p)3H from 63 to 71 MeV. PMID- 9967259 TI - Absolute differential cross section measurements for proton-deuteron elastic scattering at 641.3 and 792.7 MeV. PMID- 9967261 TI - In-beam gamma -ray spectroscopy of the N=Z+1 nucleus 63Ga. PMID- 9967260 TI - Supersymmetric quantum mechanics, phase equivalence, and low energy scattering anomalies. PMID- 9967262 TI - Conversion electron spectroscopy of high spin states in 143,144Nd. PMID- 9967263 TI - Empirical density-dependent effective interaction for nucleon-nucleus scattering at 500 MeV. PMID- 9967265 TI - Quadrupole moments of isomers in the A=90 region and the tilted-foil polarization of a separated reaction-product beam. PMID- 9967264 TI - Spectroscopy of 18O: 14C(7Li,t gamma )18O reaction; observation of selective enhanced E1 deexcitations of cluster states. PMID- 9967266 TI - Electroexcitation of negative-parity states in 18O. PMID- 9967267 TI - Short lifetimes in mirror nuclei 25Mg-25Al. PMID- 9967268 TI - Measurement of magnetic monopole transition in electron scattering from 16O as direct test of dispersive effects. PMID- 9967269 TI - Energy dependence of 1(+) spin excitations in 28Si. PMID- 9967272 TI - High-spin anomalies of Yb isotopes in interacting-boson-plus-two-fermion-pair model. PMID- 9967270 TI - High spin states in 141Eu. PMID- 9967271 TI - Pairing effects in nuclear collective motion: Generator coordinate method. PMID- 9967273 TI - Dependence of the Fermi energy upon neutron excess. PMID- 9967274 TI - Nuclear stretching. PMID- 9967276 TI - Theory of large-amplitude collective motion applied to the structure of 28Si. PMID- 9967275 TI - Binding energy and momentum distribution of nuclear matter using Green's function methods. PMID- 9967277 TI - Test of the composite particle representation theory. PMID- 9967278 TI - Analytic formula for B(E2) values in even-even nuclei with A>60. PMID- 9967279 TI - 12C(n,p)12B reaction at 56, 60, and 65 MeV. PMID- 9967280 TI - Hexadecapole deformation effects in subbarrier fusion reactions. PMID- 9967281 TI - Deformation of sd-shell nuclei derived from inelastic scattering of 50 MeV alpha particles. PMID- 9967282 TI - Production of neutron-unbound states in intermediate-mass fragments from 14N+Ag reactions at E/A=35 MeV. PMID- 9967283 TI - Scattering of polarized and unpolarized neutrons from 93Nb from 8 to 17 MeV and optical model descriptions. PMID- 9967284 TI - Elastic and inelastic scattering of 8Li from 12C. PMID- 9967286 TI - Schematic model based on two-center shell model for neutron sub-Coulomb transfer in colliding deformed and oriented 24Mg nuclei. PMID- 9967285 TI - Nuclear transport models can reproduce charged-particle-inclusive measurements but are not strongly constrained by them. PMID- 9967287 TI - Semiclassical distorted wave model of nucleon inelastic scattering to continuum. PMID- 9967288 TI - Model solutions of regularized relativistic transport equations. PMID- 9967289 TI - Off-shell effects in elastic scattering of protons by nuclei. PMID- 9967291 TI - Characteristics of helium fragments produced in 28Si emulsion interactions at 14.5A GeV. PMID- 9967290 TI - Convergence of the nucleus-nucleus Glauber multiple scattering series. PMID- 9967293 TI - Formation time of multiparticle systems in the string model. PMID- 9967292 TI - Incoherent two-photon production of the Higgs boson in relativistic heavy-ion collisions. PMID- 9967294 TI - Isotope yield ratios of fragments from heavy-ion reactions. PMID- 9967296 TI - Confirmation and consequences of a reduced pion-nucleon coupling constant. PMID- 9967295 TI - Recoil effects of neutrons evaporated in fusion-fission reactions. PMID- 9967297 TI - Many-body correlations effects in quasielastic electron scattering. PMID- 9967298 TI - Nonlocality of the optical potential and the adiabatic approximation. PMID- 9967299 TI - 129-133Ce isotopes in interacting-boson-plus-fermion model. PMID- 9967300 TI - Neutron i13/2 orbital in the A=120-140 mass region. PMID- 9967301 TI - Comment on "Quasielastic electron scattering and Coulomb sum rule in 4He" PMID- 9967302 TI - Erratum: Pion-nucleon interaction and neutral-pion photoproduction on the proton near threshold PMID- 9967303 TI - Comparison of nucleus-nucleus interactions at 14.5-200A GeV with a multistring model. PMID- 9967304 TI - High-spin states of 175Ir: Quasiproton-induced shapes and extreme interaction strength. PMID- 9967305 TI - Tracking the dissipation of energy and angular momentum in central collisions between Ag and 40Ar of 7, 17, 27, and 34 MeV/nucleon. PMID- 9967306 TI - Electron scattering off the ground-state band and the gamma band in 150Nd. PMID- 9967307 TI - Calculations of hadronic dissociation of 28Si projectiles at 14.6A GeV by nucleon emission. AB - An optical potential abrasion-ablation collision model is used to calculate hadronic dissociation cross sections for one, two, and three nucleon removal for the first time for a 14.6A GeV 28Si beam fragmenting in aluminum, tin, and lead targets. These estimates are compared with recent semi-inclusive measurements. Significant differences between some calculated and measured semi-inclusive cross sections exist which cannot be resolved without measurements of the exclusive channel hadronic cross sections. Calculations for each exclusive reaction channel contributing to the semi-inclusive cross sections are presented and discussed. PMID- 9967308 TI - Hybrid random-phase-approximation-cluster model for the dipole strength function of 11Li. PMID- 9967309 TI - Current conservation and interaction currents with relativistic separable interactions. PMID- 9967310 TI - Nucleon-nucleon scattering in the 0-6 GeV range and the relativistic optical model based on deep attractive forbidden state potentials. PMID- 9967311 TI - Isovector content of N-N potentials and Pauli-forbidden states. PMID- 9967312 TI - 24Mg states observed via 20Ne( alpha, alpha 0)20Ne. PMID- 9967313 TI - Tests of microscopic calculations of multiple band structures and large deformations in 68Ge and 72Se. PMID- 9967314 TI - 26Mg nuclear structure from 26Mg(200 MeV)+208Pb scattering. PMID- 9967315 TI - Multipole strength in 16O(n,p)16N at 298 MeV. PMID- 9967316 TI - Quadrupole moments of high-spin isomers in neutron-deficient Bi isotopes. PMID- 9967317 TI - Deformation increase of high-spin core-excited isomers in the astatine nuclei. PMID- 9967319 TI - Directional correlations of gamma transitions in 135Xe following the decay of 135I. PMID- 9967318 TI - Spectroscopy of 205Tl by means of the 208Pb(p PMID- 9967320 TI - Structure of highly deformed 102Zr populated in decay of low- and high-spin isomers of 102Y. PMID- 9967322 TI - Nuclear matter within the continuous choice. PMID- 9967321 TI - Search for a fine structure in the 14C decay of 222Ra. PMID- 9967323 TI - Description of the light barium isotopes in the interacting boson-fermion model. PMID- 9967325 TI - Pion condensation in the Walecka model. PMID- 9967324 TI - Effect of pairing on breathing mode and nuclear matter compressibility. PMID- 9967327 TI - Particle number fluctuations in the moment of inertia. PMID- 9967326 TI - Chaos in the low-lying collective states of even-even nuclei: Classical limit. PMID- 9967328 TI - Negative-parity states of Er isotopes in the interacting-boson-plus-a-fermion pair model. PMID- 9967329 TI - Adiabatic time-dependent Hartree-Fock theory with the Skyrme interaction. PMID- 9967330 TI - Pion correlations in relativistic heavy ion collisions for three symmetric systems. PMID- 9967332 TI - Mean field deflection in peripheral heavy-ion collisions. PMID- 9967333 TI - Elastic transfer in the 11B+12C system in the c.m. energy range 5-40 MeV. PMID- 9967331 TI - Populations of excited states and reaction mechanisms in the emission of complex fragments for collisions of 58Ni+58Ni at 11 MeV/nucleon. PMID- 9967335 TI - Elastic scattering of protons from 11Li and the neutron halo. PMID- 9967336 TI - Origin of transverse momentum in relativistic heavy-ion collisions: Microscopic study. PMID- 9967334 TI - Charged-pion production in noninclusive proton-nucleus interactions at 0.8 and 1.6 GeV incident energies. PMID- 9967337 TI - Starting energy dependence of elastic scattering observables in a full-folding model. PMID- 9967339 TI - Generalization of the Frenkel-Dirac variational principle for systems outside thermal equilibrium. PMID- 9967340 TI - Realistic A=7 hypernuclear productions. PMID- 9967338 TI - 0(+)-0(+) transition in charged photopion reactions. PMID- 9967341 TI - Unified formalism to study nonstatistical effects in radiative capture reactions. PMID- 9967342 TI - Neutron relativistic phenomenological and microscopic optical potential. PMID- 9967343 TI - Light-front sum rules. PMID- 9967344 TI - Quark-gluon-plasma signatures? PMID- 9967346 TI - Chiral solitons with quarks and composite mesons. PMID- 9967345 TI - Analysis of multiparticle Bose-Einstein correlations in ultrarelativistic heavy ion collisions. PMID- 9967347 TI - European Muon Collaboration effect: Nuclear-binding effect or vivid quark signature? PMID- 9967349 TI - Dynamical multicluster model for electroweak and charge-exchange reactions. PMID- 9967348 TI - Limits on nonstandard weak currents from the polarization of 14O and 10C decay positrons. PMID- 9967350 TI - One-body parity and time reversal violating potentials. PMID- 9967351 TI - Properties of 22Ne( alpha,n)25Mg resonances. PMID- 9967352 TI - Cu(p,X)24Na cross section from 30 to 800 GeV. PMID- 9967353 TI - Kinematically complete study of the 7Li(p, gamma )8Be*-->2 alpha reaction at Ep=25 MeV. PMID- 9967354 TI - Resonances and decay modes of 27Al+p for Ep=3.58-4.06 MeV. PMID- 9967355 TI - 31Si(2.6 h)(n, gamma )32Si cross section measured by accelerator mass spectrometry. PMID- 9967356 TI - Equivalent local potentials in a coupled-channel Dirac phenomenology. PMID- 9967357 TI - Nonpairing like-nucleon valence residual interactions. PMID- 9967358 TI - Model-space-size dependence of nuclear matter model-space Brueckner-Hartree-Fock calculations. PMID- 9967360 TI - Spontaneous breaking of Elliott symmetry in nuclear systems and the s and d Nambu Goldstone bosons. PMID- 9967359 TI - Unitary pole approximation for the Coulomb-plus-Yamaguchi potential and application to a three-body bound-state calculation. PMID- 9967361 TI - Comment on "Triton model calculation test of the Bonn W-matrix rank-one approximation" PMID- 9967363 TI - Erratum: "Scissor mode applied to the yrast band of the rare-earth nuclei nuclei" PMID- 9967362 TI - Reply to "Comment on 'Triton model calculation test of the Bonn W-matrix rank-one approximation' " PMID- 9967364 TI - Erratum: "Upper limits on emission of neutrons from Ti in pressurized D2 gas cells: A test of evidence for "cold fusion" " PMID- 9967365 TI - Superdeformation in 198,196Pb. PMID- 9967366 TI - Statistical and nonstatistical neutron decay of the giant electric dipole resonance of 208Pb. PMID- 9967368 TI - Statistical and nonstatistical photon emission from giant resonances. PMID- 9967367 TI - Characterization of very highly excited composite nuclei: Temperature, spin zone, radial extent, and lifetime scale of 10(-)22 s. PMID- 9967369 TI - Absolute differential cross sections and charge asymmetries for pi +/-d elastic scattering at 65 MeV. PMID- 9967370 TI - Inclusive inelastic scattering of 96.5-MeV pi + and pi - by the hydrogen and helium isotopes. PMID- 9967371 TI - 3He( gamma,np)p reaction in quasi-deuteron kinematics. PMID- 9967373 TI - Nd zero-energy scattering. PMID- 9967372 TI - Absolute measurement of the p+p analyzing power at 183 MeV. PMID- 9967374 TI - Numerical quasiparticle representation of the nucleon-nucleon T matrix. PMID- 9967375 TI - Relation between the bound state radius and the scattering length: Relativistic effects. PMID- 9967376 TI - Parametrization scheme for effective interactions. PMID- 9967377 TI - Integro-differential equation approach. III. Triton and alpha -particle bound states. Realistic forces and two-body correlations. PMID- 9967378 TI - Spin decomposition of the responses of 44Ca and 48Ca to 300 MeV protons. PMID- 9967379 TI - Magnetic moments around the Z=40 shell closure: 91Ym, 95Zr, and 97Nb. PMID- 9967381 TI - Level structure of 101Tc investigated by means of massive transfer reactions. PMID- 9967380 TI - Excitation of 24Mg states through the interaction of 85 MeV 16O ions with 12C and 24Mg targets. PMID- 9967382 TI - Isospin character of transitions to bound states in 204,206,208Pb using inelastic scattering of 17O ions. PMID- 9967383 TI - Inelastic electron scattering to collective states of 118Sn. PMID- 9967384 TI - Description of nuclear structure effects in sub-barrier fusion by the interacting boson model. PMID- 9967385 TI - Algebraic approach to cluster states in odd-mass nuclei. I. Energy spectrum. PMID- 9967386 TI - Algebraic approach to cluster states in odd-mass nuclei. II. Electromagnetic and other properties. PMID- 9967387 TI - Multi-lambda matter in a derivative coupling model. PMID- 9967388 TI - Time-dependent mean field description of a two-level bosonic model. PMID- 9967389 TI - Empirical effective interactions in the lower fp shell and upper sd shell. PMID- 9967390 TI - Wave function effects and the elastic magnetic form factor of 17O. PMID- 9967391 TI - Collective modes in relativistic nuclear matter: Classical approach. PMID- 9967392 TI - Alpha decay hindrance factors and reflection asymmetry in nuclei. PMID- 9967394 TI - First-forbidden beta decay in the lead region and mesonic enhancement of the weak axial current. PMID- 9967393 TI - Two-quasiparticle states in the interacting boson model. II. Electromagnetic properties in the SU(3) limit. PMID- 9967395 TI - Shell-model interpretation of the beta - decay of 212Big, 212Bim1, and 212Bim2. PMID- 9967396 TI - Shell-model predictions for 41,42Cl( beta -)41,42Ar and the A=41-43 Ar isotopes. PMID- 9967397 TI - Pion double-charge-exchange reaction: Shell model formalism. PMID- 9967398 TI - Alpha-particle scattering and isoscalar giant resonances in the SU(3) model. PMID- 9967399 TI - Comparison of various parametrizations of the double-humped fission barrier. PMID- 9967400 TI - Clustering effects in a microscopic four- alpha description of the alpha +12C system. PMID- 9967401 TI - Methods of statistical physics in heavy nucleus collision theory. PMID- 9967402 TI - Measurements of vector analyzing power in the (d PMID- 9967403 TI - 4H nucleus and the 2H(t,tp)n reaction. PMID- 9967404 TI - Quasifree knockout in 16O(p,2p)15N at an incident energy of 151 MeV. PMID- 9967406 TI - Test of level densities with proton resonances. PMID- 9967405 TI - Independent and cumulative yields of very neutron-rich nuclei in 20 MeV p- and 18 41 MeV d-induced fission of 238U. PMID- 9967407 TI - Absolute photofission cross section of 197Au, natPb, 209Bi, 232Th, 238U, and 235U nuclei by 69-MeV monochromatic and polarized photons. PMID- 9967408 TI - Deuteron production in alpha -nucleus collisions from 200 to 800 MeV per nucleon. PMID- 9967410 TI - Correlations between energy and mass partition in the damped reaction 165Ho+74Ge at Elab=8.5 MeV/nucleon. PMID- 9967409 TI - Neutron inclusive measurements of 36Ar+Ag reactions at 35 MeV/nucleon. PMID- 9967411 TI - (12C,12B) and (12C,12N) reactions at E/A=70 MeV as spin probes: Calibration and application to 1(+) states in 56Mn. PMID- 9967412 TI - Pion-nucleus scattering at 800 MeV/c. PMID- 9967413 TI - Expectations of fragment decay from highly excited nuclei. PMID- 9967414 TI - Angular distribution of neutrons emitted in (11Li,9Li) breakup reactions. PMID- 9967415 TI - Role of the pygmy resonance in the synthesis of heavy elements with radioactive beams. PMID- 9967416 TI - Pion spectra in a hadronic transport model for relativistic heavy ion collisions. PMID- 9967418 TI - Pion-induced elastic and inelastic scattering above the 3,3 resonance. PMID- 9967417 TI - Microscopic calculation for Ne on NaF at 45 MeV per nucleon. PMID- 9967419 TI - Dynamic polarization potential induced by the Coulomb excitation of deformed heavy ions: Geometric scattering approach. PMID- 9967420 TI - Currents and Ward-Takahashi identities for nonlocal quantum field theories. PMID- 9967422 TI - Limits on charge nonconservation studied by nuclear excitation of 127I. PMID- 9967421 TI - Isovector parity mixing in 16O investigated via the 15N(p PMID- 9967423 TI - Stellar production cross section of 176Lum. PMID- 9967424 TI - Compound nucleus origin of back-angle yields in the 31P+16O and 35Cl+12C reactions. PMID- 9967425 TI - Thermal-neutron scattering length and capture by 46Ca. PMID- 9967427 TI - Average resonance capture study of 124Te. PMID- 9967426 TI - Near-symmetric breakup of 25Mg. PMID- 9967429 TI - Broken Goldstone symmetry and low-energy theorem for pion photoproduction on a nucleon. PMID- 9967428 TI - Infrared structure of quantum hadrodynamics. PMID- 9967430 TI - Parametrization of total and differential cross sections for pi d-->pp below 1 GeV. PMID- 9967431 TI - Single-particle resonances in continuum nuclear structure calculations. PMID- 9967433 TI - Critical energy deposit in heavy ion complete fusion. PMID- 9967432 TI - Momentum transfer in relativistic heavy ion charge-exchange reactions. AB - Relativistic heavy ion charge-exchange reactions yield fragments (delta Z = +1) whose longitudinal momentum distributions are downshifted by larger values than those associated with the remaining fragments (delta Z = -1, -2, ...). Kinematics alone cannot account for the observed downshifts; therefore, an additional contribution from collision dynamics must be included. In this work, an optical model description of collision momentum transfer is used to estimate the additional dynamical momentum downshift. Good agreement between theoretical estimates and experimental data is obtained. PMID- 9967434 TI - Microscopic description of alpha decay of deformed nuclei. PMID- 9967435 TI - Lambda -hypernuclei magnetic moments in a relativistic model. PMID- 9967436 TI - Comment on "Kaon photoproduction: Data consistency, coupling constants, and polarization observables" PMID- 9967437 TI - Comment on "Resonant and nonresonant contributions to the photoactivation of 111Cd" PMID- 9967438 TI - Comment on "Comparison of realistic and symmetry-determined S and D pairs for 156Gd" PMID- 9967439 TI - Reply to "Comment on 'Comparison of realistic and symmetry-determined S and D pairs for 156Gd' " PMID- 9967440 TI - Erratum: Pion-nucleus scattering around the (3,3) resonance PMID- 9967442 TI - Radiative corrections to 10C superallowed Fermi beta decay. PMID- 9967441 TI - Proton-induced fission of 238U at extreme sub-barrier energies. PMID- 9967443 TI - Two-nucleon correlations and the structure of the nucleon spectral function at high values of momentum and removal energy. PMID- 9967444 TI - 9Li and neutron momentum distributions in 11Li in a simplified three-body model. PMID- 9967445 TI - Decays of the K-p atom and the Lambda (1405). PMID- 9967446 TI - Antiproton-induced elastic and inelastic scattering at intermediate energies. PMID- 9967448 TI - Level scheme of 116Sb from (p,n gamma ) reaction. PMID- 9967447 TI - Weak proton capture reactions on 1H and 3He and tritium beta decay. PMID- 9967450 TI - Evidence for parity dependence in the neutron-40Ar optical model potential. PMID- 9967449 TI - Structure of 116Sb nucleus. PMID- 9967451 TI - High spin and shape coexistence in 73Se. PMID- 9967452 TI - 219Fr, a transitional reflection asymmetric nucleus. PMID- 9967453 TI - Energy dependence of stretched states excited in (p,n) reactions. PMID- 9967455 TI - Momentum-space method for pionic atoms. PMID- 9967454 TI - Inelastic proton scattering from Pt isotopes and the interacting boson model. PMID- 9967456 TI - Radial characteristics for nuclear states with weakly bound nucleons. PMID- 9967457 TI - Nuclear response function at finite temperature. PMID- 9967458 TI - Width of bound eta in nuclei. PMID- 9967459 TI - Reaction mechanisms in the 32S+64Ni collision. PMID- 9967460 TI - 40Ca photoneutron cross section above the giant dipole resonance. PMID- 9967461 TI - Direct and valence neutron capture by 7Li. PMID- 9967462 TI - Charged-particle evaporation from hot composite nuclei: Evidence over a broad Z range for distortions from cold nuclear profiles. PMID- 9967463 TI - Quantum mechanical reflective model for heavy ion scattering. PMID- 9967464 TI - Final-state-interaction effects in the (e,e'p) reaction. PMID- 9967465 TI - Pauli-blocking in the quasideuteron model of photoabsorption. PMID- 9967466 TI - Transition from binary processes to multifragmentation in quantum molecular dynamics for intermediate energy heavy ion collisions. PMID- 9967468 TI - Production of fast and slow particles in nucleus-nucleus collisions at ultrarelativistic energies. PMID- 9967467 TI - Contribution of nonthermodynamic processes to the formation of helium fragment in nucleus-nucleus collisions at 1.88A GeV. PMID- 9967469 TI - One- and two-dimensional analysis of intermittency in ultrarelativistic nucleus nucleus interactions. PMID- 9967471 TI - Nucleon binding corrections to lepton-nucleus deep inelastic scattering: Use of a realistic spectral function. PMID- 9967470 TI - Shear instability and entropy generation in heavy-ion collisions. PMID- 9967472 TI - Scale breaking in dense nuclear matter. PMID- 9967473 TI - Color-dielectric-model nucleon in the nuclear medium. PMID- 9967474 TI - Neon radioactivity of uranium isotopes. PMID- 9967476 TI - Charge density differences near 208Pb in relativistic models. PMID- 9967475 TI - Shape coexistence in 140Sm and the onset of deformation below N=82 from lifetime measurements. PMID- 9967477 TI - Consequences of an alternate Skyrmion stabilizing term for the NN force. PMID- 9967478 TI - Soft pion emission from fat flux tubes. PMID- 9967479 TI - Thermal and quantal fluctuations in a model with repulsive potential. PMID- 9967480 TI - Interpretation of backbending in 100Mo in a cranked Nilsson model with pairing. PMID- 9967481 TI - Microscopic analysis of 34S(d PMID- 9967483 TI - Comment on "Preequilibrium emission of hard photons in proton-nucleus reactions" PMID- 9967482 TI - Projectile breakup by nuclear and Coulomb fields and application to astrophysically relevant radiative-capture processes. PMID- 9967485 TI - Erratum: Diproton decay of nuclei on the proton drip line PMID- 9967484 TI - Reply to "Comment on 'Preequilibrium emission of hard photons in proton-nucleus reactions' " PMID- 9967486 TI - Determination of the neutron electric form factor in quasielastic scattering of polarized electrons from polarized 3He. PMID- 9967487 TI - Direct observation of a three-body mechanism in the reaction 3He( gamma,pp)n. PMID- 9967488 TI - Band termination in 121I. PMID- 9967490 TI - Directional correlation between alpha particles and L x rays in the decay of 238Pu and 244Cm. PMID- 9967489 TI - Light particle correlations for the 3He+Ag reaction at 200 MeV. PMID- 9967492 TI - Significance of the light clusters in exotic nuclear decay. PMID- 9967491 TI - Multifragmentation for 36Ar+238U treated as statistical dynamic interaction processes. PMID- 9967494 TI - Integer alignment and strong coupling limit in superdeformed nuclei. PMID- 9967493 TI - Unified pair-coupling theory of fermion systems. PMID- 9967496 TI - Three-body K+d reactions. PMID- 9967495 TI - pi -p--> pi 0 pi 0n near threshold and chiral symmetry breaking. PMID- 9967497 TI - Reaction 52Cr(p, gamma )53Mn from 1.66 to 2.91 MeV. PMID- 9967499 TI - Conserving relativistic many-body approach: Equation of state, spectral function, and occupation probabilities of nuclear matter. PMID- 9967498 TI - Structure of 75Se. PMID- 9967500 TI - In-medium and core-polarization effects in 50K(0(-))long-> beta -50Ca(0(+)). PMID- 9967501 TI - Projection onto physical boson states in a collective subspace. PMID- 9967502 TI - Optimal auxiliary Hamiltonians for truncated boson-space calculations by means of a maximal-decoupling variational principle. PMID- 9967504 TI - Fragmentation of gold projectiles with energies of 200-980 MeV/nucleon. I. Experimental method, charge yields, and transverse momenta. PMID- 9967503 TI - Heavy fragment emission in alpha-induced reactions on aluminum at 60 MeV. PMID- 9967505 TI - Fragmentation of gold projectiles with energies of 200-980 MeV/nucleon. II. Multiplicity distributions and correlations. PMID- 9967506 TI - Excitation of the 10.957 MeV 0(-);T=0 state in 16O by 400 MeV protons. PMID- 9967507 TI - Cold multiproton-transfer reactions in the system 86Kr+54Fe below the Coulomb barrier. PMID- 9967508 TI - 103Rhm production by inelastic gamma scattering in the giant dipole resonance region. PMID- 9967510 TI - Energy dependence of the form factor for elastic electron scattering from 12C. PMID- 9967509 TI - Measurement of collective flow in heavy-ion collisions using particle-pair correlations. PMID- 9967511 TI - Independent yields from the photofission of 232Th, and the Zp and statistical dynamic models. PMID- 9967512 TI - Properties of high spin states in 53Cr and 53Mn. PMID- 9967513 TI - 14C photoproton cross section. PMID- 9967514 TI - Channel-capture mechanism in low-energy neutron capture by 12C. PMID- 9967515 TI - Inversion potential for the alpha +12C system. PMID- 9967516 TI - Boost, recoil, and Wigner rotation effects on no-pair analyses of proton elastic scattering. PMID- 9967517 TI - Microscopic study of the alpha -16O interaction on the basis of the complex effective interaction and the totally antisymmetrized many-body theory. PMID- 9967518 TI - Relativistic sigma - omega mean-field theory for hyperons from a quark model. PMID- 9967520 TI - Extent of simultaneous parity and time violation in 182W. PMID- 9967519 TI - Dilepton production by protons on nuclei and the partonic origin of depletion at small momentum fraction. PMID- 9967521 TI - Rotational bands with identical transition energies in actinide nuclei. PMID- 9967522 TI - Identification of 185Pt alpha activity and study of 185Au alpha decay. PMID- 9967523 TI - Experimental search for coherent subthreshold pion production. PMID- 9967524 TI - Atomic final-state effects in nuclear transitions. PMID- 9967525 TI - Convenient parametrization for deep inelastic structure functions of the deuteron. PMID- 9967526 TI - Split-bin correlation-function analysis of O+Ag(Br) and S+Ag(Br) collisions at 200 GeV/nucleon. PMID- 9967527 TI - Erratum: 11B+ alpha reaction rates and primordial nucleosynthesis PMID- 9967528 TI - Detection of neutrinoless double-beta decay. PMID- 9967529 TI - Identification of the rare neutron-rich isotope 117Rh. PMID- 9967530 TI - Study of the proton 2p3/2-->2p1/2 transition in 65Cu and 71Ga. PMID- 9967531 TI - 330-keV electron line in e++Th interactions. PMID- 9967532 TI - Superdeformation in the quasicontinuum: Microscopic view of the excited superdeformed bands and the corresponding level densities. PMID- 9967533 TI - Direct reaction analysis of 19F(p,a)16O below the Coulomb barrier. PMID- 9967534 TI - Isospin mixing in protonium and annihilation dynamics. PMID- 9967535 TI - Analytical structure of the S matrix for the coupled channel problem d+t n+ alpha and the interpretation of the J pi =3/2(+) resonance in 5He. PMID- 9967537 TI - Formalism for the systematic solution of the low-energy pion-trinucleon scattering problem. PMID- 9967536 TI - Proton-proton bremsstrahlung calculations at 280 MeV. PMID- 9967538 TI - Meson-baryon dynamics in the nucleon-antinucleon system. I. The nucleon antinucleon interaction. PMID- 9967540 TI - Coupled-reaction-channel calculation of a model n-d scattering problem above the breakup threshold. PMID- 9967539 TI - Meson-baryon dynamics in the nucleon-antinucleon system. II. Annihilation into two mesons. PMID- 9967541 TI - Delta degrees of freedom in trinuclei: I. The Hannover one- Delta model. PMID- 9967542 TI - High spin spectroscopy and lifetime measurements in 169Hf. PMID- 9967543 TI - Decay history and magnetic moments at high spin in 152Dy. PMID- 9967544 TI - Mass yield curves in low-energy proton-induced fission of 233U, 235U, 236U, 237Np, 239Pu, 242Pu, 244Pu, 241Am, and 243Am. PMID- 9967546 TI - Half-lives and delayed neutron emission probabilities of neutron-rich Li-Al nuclides. PMID- 9967545 TI - Fine structure in 14C emission from 223Ra and 224Ra. PMID- 9967547 TI - Multiparticle-multihole configuration mixing within the neutron-proton interacting boson model. PMID- 9967548 TI - Role of final-state interactions in the calculation of the hadronic tensor of nuclear matter. PMID- 9967550 TI - Gamow-Teller decay of N=50 nuclei. PMID- 9967549 TI - Relativistic Hartree theory for nuclei far from the stability line. PMID- 9967552 TI - Symmetry group of point transformations for the time-dependent Schrodinger equation: Harmonic interactions among nucleons. PMID- 9967551 TI - Isospin splitting in double isovector excitations. PMID- 9967553 TI - Mass and charge attributes of heavy ion potentials obtained by inversion. PMID- 9967554 TI - Shell-model description of 211Bi( beta -)211Po and 211At(EC)211Po and the spectroscopy of 211Po. PMID- 9967555 TI - Full-symmetry and mixed-symmetry states in 110,112,114Cd. PMID- 9967556 TI - Time scales for fusion-fission and quasifission from giant dipole resonance decay. PMID- 9967557 TI - Recoil range study of complete and incomplete fusion of C with Au at 10 MeV/nucleon. PMID- 9967559 TI - Search for high energy gamma rays from the spontaneous fission of 252Cf. PMID- 9967558 TI - Strangeness production in proton and heavy-ion collisions at 14.6A GeV. PMID- 9967561 TI - Stripping to the continuum of 208Pb. PMID- 9967560 TI - Features of compound multiplicity in heavy-ion interactions at 4.5A GeV/c. PMID- 9967562 TI - Momentum-space treatment of Coulomb distortions in a multiple-scattering expansion. PMID- 9967563 TI - Effects of nonresonant breakup states in polarized 6Li scattering. PMID- 9967564 TI - Approximate treatment of the nucleon-nucleus interaction in the resonating-group formulation. PMID- 9967565 TI - Refinements to the treatment of scattering in Vlasov-Boltzmann calculations. PMID- 9967566 TI - Heavy-ion potentials derived from strong-absorption-model parametrizations of the scattering function. PMID- 9967567 TI - Forward and transverse energies in relativistic heavy ion collisions at 14.6 GeV/c per nucleon. PMID- 9967568 TI - Correlations and intermittency in high-energy nuclear collisions. PMID- 9967570 TI - Particle-hole symmetry, F-spin, and r-process parameters. PMID- 9967569 TI - Covariant coalescence model for relativistically expanding systems. PMID- 9967572 TI - Width of the 0.55-MeV resonance in 13C(p, gamma ). PMID- 9967571 TI - Target fragmentation of silver by 14.6 GeV/nucleon 16O ions. PMID- 9967573 TI - Test of octupole coupled 5(-) state in 146Nd using proton inelastic scattering. PMID- 9967575 TI - 35Cl(n,p)35S cross section from 25 meV to 100 keV. PMID- 9967574 TI - Search for fractional charge states in high-energy heavy fragments produced in collisions of 14.5A GeV 28Si with Pb and Cu target. PMID- 9967577 TI - Fission of complex nuclei induced by 52-MeV monochromatic and polarized photons. PMID- 9967576 TI - Elastic magnetic electron scattering from 13C at Q2=1 GeV2/c2. PMID- 9967578 TI - Measurement of cross sections for charge pickup by relativistic holmium ions on heavy targets. PMID- 9967579 TI - Analyzing powers for the 3He(p PMID- 9967581 TI - Energy dependence of 6Li+28Si elastic scattering and the dispersion relation. PMID- 9967580 TI - Approximate treatment of antisymmetrization in the microscopic studies of p+ alpha and 3He+ alpha bremsstrahlung. PMID- 9967583 TI - Coulomb sum rule in heavier nuclei. PMID- 9967582 TI - Proton-neutron multiplet structure of 104In. PMID- 9967584 TI - Energy levels of a muonic hydrogen atom with the use of a quark model. PMID- 9967585 TI - Damping of giant resonances in hot nuclei. PMID- 9967586 TI - Erratum: Systematic behavior of one- and two-nucleon transfer reactions induced by medium-weight projectiles PMID- 9967587 TI - Spin-flip probabilities in Pb208 measured with 200 MeV protons. PMID- 9967588 TI - Small-angle two-neutron and two-proton correlations in 30A MeV heavy-ion reactions. PMID- 9967590 TI - Shape coexistence from the structure of the yrast band in 174Pt. PMID- 9967589 TI - Intermediate mass fragments from 40Ar+197Au: Transition from the incomplete fusion to the participant spectator regime. PMID- 9967592 TI - Spin observables in pp bremsstrahlung and off-shell effects of the NN interaction. PMID- 9967591 TI - Orbital 1(+) strengths from self-consistent deformed mean field calculations. PMID- 9967593 TI - Determination of the NN pi coupling constants in NN partial-wave analyses. PMID- 9967594 TI - Three-body force effect in triton dipole sum rules. PMID- 9967595 TI - Distribution of single-particle strength due to short-range and tensor correlations. PMID- 9967596 TI - Classical European-Muon-Collaboration effect from few-body systems to nuclear matter: Can binding effects explain it? PMID- 9967597 TI - M1 excitation in Sm isotopes and the proton-neutron sdg interacting boson model. PMID- 9967599 TI - p( gamma, pi 0) cross section and the low energy theorem. PMID- 9967598 TI - Spin observables at threshold for the reaction p-barp--> Lambda -bar Lambda. PMID- 9967600 TI - Pion absorption on 3He: Absorption amplitude in the Faddeev-quasiparticle scheme. PMID- 9967602 TI - Bonn nucleon-nucleon meson exchange model with a relativistic quark-gluon annihilation potential. PMID- 9967601 TI - Solution of the Chandler-Gibson equations for a three-body test problem. PMID- 9967603 TI - Pion-proton bremsstrahlung calculation and the "experimental" magnetic moment of Delta ++(1232). PMID- 9967604 TI - E0 components of 2i+-->2f+ transitions in even cadmium isotopes and effective monopole charges. PMID- 9967605 TI - Excitation functions for actinides produced in the interactions of 31P with 248Cm. PMID- 9967606 TI - Direct observation of the giant dipole resonance of 16O via electromagnetic dissociation. PMID- 9967607 TI - Investigation of A=155 and A=151 nuclides: Identification of the 155Tm s1/2 isomer and of the 155Yb beta -decay branch. PMID- 9967608 TI - Monopole strength in 58Ni. PMID- 9967610 TI - Asymmetric nuclear matter equation of state. PMID- 9967609 TI - High-spin gamma spectroscopy of recoil-separated 49Cr, 49V, and 46Ti. PMID- 9967612 TI - Interpretation of a double hypernucleus event. PMID- 9967611 TI - Identification of nuclear cluster-molecular states. PMID- 9967614 TI - Retardation effect in finite nuclei in relativistic mean field theory. PMID- 9967613 TI - Probability and selection rule for nuclear excitation by electron transition. PMID- 9967615 TI - Interacting-boson-fermion-approximation description of negative-parity states in even-odd Yb isotopes. PMID- 9967616 TI - Semiclassical description of alpha clustering in heavy nuclei. PMID- 9967617 TI - Mean free path in the relativistic mean field. PMID- 9967618 TI - Velocity spectra and angular distributions of evaporation residues from 32S +12C at 145 MeV. PMID- 9967619 TI - Spatial information on the pion-emitting source from pion interferometry. PMID- 9967620 TI - Neutron and proton transition densities from 32,34S(p,p') at Ep=318 MeV. I. Isoscalar densities for 32S. PMID- 9967622 TI - Polarization transfer in the 23Na(p PMID- 9967623 TI - Mechanism of the 6Li(e,e' alpha ) reaction. PMID- 9967621 TI - Neutron and proton transition densities from 32,34S(p,p') at Ep=318 MeV. II. Neutron densities for 34S. PMID- 9967624 TI - Measurement of Ay( theta ) for n+208Pb from 6 to 10 MeV and the neutron-nucleus interaction over the energy range from bound states at -17 MeV up to scattering at 40 MeV. PMID- 9967625 TI - Mass dependence of high-energy pion double charge exchange. PMID- 9967626 TI - Elastic scattering of pi + and pi - from 4He between 90 and 240 MeV. PMID- 9967627 TI - Complete spin-transfer measurements for inelastic polarized proton scattering from 12C. PMID- 9967628 TI - Inelastic transfer in the 11B+12C system in the c.m. energy range 15-40 MeV. PMID- 9967629 TI - Energy dependence of pion inelastic scattering from 208Pb. PMID- 9967630 TI - Reaction plane determination for 36Ar+197Au collisions at E/A=35 MeV. PMID- 9967632 TI - Preferential emission of pions in asymmetric nucleus-nucleus collisions. PMID- 9967631 TI - Forward nuclear glory in 12C+12C scattering. PMID- 9967633 TI - From Dirac phenomenology to deuteron-nucleus elastic scattering at intermediate energies. PMID- 9967635 TI - y-scaling analysis for inelastic scattering from relativistic targets. PMID- 9967634 TI - Multifragmentation near the threshold. PMID- 9967637 TI - Spin-dependent effects in the quark-cluster model of the deuteron and 3He. PMID- 9967638 TI - Quark mean-field theory and consistency with nuclear matter. PMID- 9967636 TI - Covariant Feynman rules at finite temperature: Time-path formulation. PMID- 9967640 TI - Measurements of the Coulomb dissociation cross section of 156 MeV 6Li projectiles at extremely low relative fragment energies of astrophysical interest. PMID- 9967639 TI - Parity nonconservation in polarized-neutron transmission through 139La. PMID- 9967641 TI - Angular distributions for the double isobaric analog and a T< state at high excitation in pion double charge exchange on 93Nb. PMID- 9967642 TI - Measurements of subnanosecond nuclear lifetimes. PMID- 9967643 TI - Proton 4p-4h intruder excitations in heavy even-even nuclei. PMID- 9967644 TI - Low energy behavior of 11Li dissociation cross section. PMID- 9967645 TI - Effect of the 1S0 neutron proton pair on positive pion absorption in 3He. PMID- 9967646 TI - Semiclassical simulation of sudden nucleus scission with two-body collisions. PMID- 9967647 TI - Derivative scalar coupling model versus sigma - omega model. PMID- 9967648 TI - Semiclassical calculation for 16O+16O elastic scattering at high energies. PMID- 9967649 TI - Comment on "Double K-shell ionization in the electron capture decay of 55Fe" PMID- 9967651 TI - Total cross section for p+p-->p+p+ pi 0 near threshold. PMID- 9967650 TI - Erratum: Measurement of the neutrons emitted in the proton-induced fission of 209Bi and 238U at 475 MeV PMID- 9967652 TI - Does a 5/2(+)-5/2(-) ground-state parity doublet exist in 229Pa? PMID- 9967653 TI - Symmetry properties of the K=0(+/-) bands in reflection asymmetric 224Ac. PMID- 9967654 TI - Multiple scattering effects in proton nucleus elastic scattering at intermediate energies. PMID- 9967655 TI - Linear momentum in the exciton model: Consistent way to obtain angular distributions. PMID- 9967656 TI - Spin determination and quantized alignment in the superdeformed bands in 152Dy, 151Tb, and 150Gd. PMID- 9967657 TI - np elastic spin transfer measurements at 788 MeV. PMID- 9967658 TI - Measurement of the Ayy tensor analyzing power for the 1H(d PMID- 9967660 TI - Force-range correction in the three-body problem: Application to three-nucleon systems. PMID- 9967659 TI - Total cross sections and analyzing powers for the reaction p+p-->p+p+ pi 0 near threshold. PMID- 9967661 TI - Effective stable particle behavior of the Delta. PMID- 9967662 TI - Faddeev equations with three-nucleon force in momentum space. PMID- 9967663 TI - Scattering of GeV electrons by nuclear matter. PMID- 9967664 TI - Projection of the six-quark wave function onto the NN channel and the problem of the repulsive core in the NN interaction. PMID- 9967665 TI - High-spin states in 48V, 51Cr, and 51Mn. PMID- 9967666 TI - beta -decay branching ratios of the neutron-rich nucleus 15B. PMID- 9967667 TI - Photon-decay modes of the giant dipole resonance in even-A Nd isotopes. PMID- 9967669 TI - Alignment effects in odd-mass Cs isotopes: Spectroscopy of 125Cs. PMID- 9967668 TI - Isospin character of the giant quadrupole transition in 124Sn. PMID- 9967670 TI - Properties of low-lying states in 142Ce via high resolution electron scattering. PMID- 9967671 TI - Pion scattering to 6(-) stretched states in 24Mg and 26Mg. PMID- 9967672 TI - Determination of the level density of 29Si from Ericson fluctuations. PMID- 9967673 TI - 0(+) and 2(+) strengths in pion double charge exchange to double giant-dipole resonances. PMID- 9967674 TI - Gamow-Teller strength from the 20Ne(n,p)20F reaction at En=198 MeV. PMID- 9967675 TI - Masses of 103,104,105In and 72,73Br. PMID- 9967677 TI - Vlasov dynamics of a semi-infinite system. PMID- 9967676 TI - High-spin structure of 189Tl: Role of h9/2 protons in the prolate minimum of light Hg isotopes. PMID- 9967678 TI - Relativistic mean-field kinetic equation: Collectives modes and symmetry breaking in nuclear matter. PMID- 9967679 TI - Pair condensates in realistic shell model states. II. M1 states in 54,56Cr and 56,58,60Fe. PMID- 9967680 TI - (d,3He) reactions for the formation of deeply bound pionic atoms. PMID- 9967681 TI - Meson exchange currents in pion double charge exchange. PMID- 9967682 TI - Strong absorption model for pion-nucleus scattering around the (3,3) resonance. PMID- 9967684 TI - Configurational assignments in 168Ho and comparison with 166Ho. PMID- 9967683 TI - Compression properties of nuclei with the derivative scalar coupling in the relativistic mean-field theory. PMID- 9967685 TI - Coulomb instability in hot nuclei with Skyrme interaction. PMID- 9967687 TI - Quadrupole collectivity of summed magnetic dipole orbital strength using schematic interactions. PMID- 9967686 TI - Nuclear Hartree-Fock calculations with splines. PMID- 9967689 TI - Projected quasiparticle calculations for the N=82 odd-proton isotones. PMID- 9967688 TI - Level matrix, 16N beta decay, and the 12C( alpha, gamma )16O reaction. PMID- 9967690 TI - Deviation of the SUq(2) prediction from observations in even-even deformed nuclei. PMID- 9967691 TI - Relativistic mean field study of light medium nuclei away from beta stability. PMID- 9967692 TI - Yrast-yrare interaction strength and bandcrossing frequency. PMID- 9967693 TI - Search for a 21.4-MeV state in 13C and (p, pi +) production mechanisms. PMID- 9967694 TI - Search for narrow-peak structure in the three-photon spectrum from 6-MeV/nucleon U+Th, U+U, and Th+Th collisions. PMID- 9967695 TI - Level density of hot nuclei with A <= 40. PMID- 9967696 TI - Population of high-spin states in 234U by heavy-ion-induced transfer reactions. PMID- 9967697 TI - Effective interaction for 40Ca(p,p') at Ep=318 MeV. PMID- 9967698 TI - Analyzing powers and isotope ratios for the natAg(p PMID- 9967700 TI - Excitation functions for the helium-ion-induced fission of holmium and erbium. PMID- 9967699 TI - Fusion of 28Si nuclei at 12.4, 19.7, and 30.0 MeV/nucleon. PMID- 9967701 TI - Proton-nucleus scattering and density dependent meson masses in the nucleus. PMID- 9967703 TI - Multipair transfer processes in heavy-ion collisions at intermediate energies. PMID- 9967702 TI - Classical model for two-proton correlations in intermediate-energy heavy-ion reactions. PMID- 9967704 TI - Fusion-fission in nuclear systems with 40 <= ACN <= 80. PMID- 9967705 TI - Coulomb distortion effects in (e,e' gamma ) processes. PMID- 9967706 TI - Dynamical polarization potential due to the excitation of collective states. PMID- 9967708 TI - Barrier region resonance model for heavy ion resonances. PMID- 9967707 TI - Heavy-ion fission probability calculations at high excitation energy. PMID- 9967710 TI - Nuclear to quark-matter transition in the string-flip model. PMID- 9967709 TI - Distributions of transverse energy and forward energy in 16O- and 32S-induced heavy ion collisions at 60A and 200A GeV. PMID- 9967712 TI - (6Li,6He) measurements as an alternative calibration for solar neutrino detectors. PMID- 9967711 TI - Threshold eta photoproduction. PMID- 9967714 TI - 17O(n, alpha )14C cross section from 25 meV to approximately 1 MeV. PMID- 9967713 TI - Target and detection techniques for the 13N(p, gamma )14O reaction using radioactive ion beams: 13C(p, gamma )14N reaction as a test case. PMID- 9967715 TI - Ground-state Gamow-Teller strength in 64Ni(n,p)64Co cross sections at 90-240 MeV. PMID- 9967716 TI - Nuclear structure of 176Lu and its astrophysical consequences. I. Level scheme of 176Lu. PMID- 9967717 TI - Nuclear structure of 176Lu and its astrophysical consequences. II. 176Lu, a thermometer for stellar helium burning. PMID- 9967718 TI - 176Lu: An unreliable s-process chronometer. PMID- 9967719 TI - Event-mixing analysis of two-proton correlation functions. PMID- 9967720 TI - Search for neutral pions from the spontaneous fission of 252Cf. PMID- 9967721 TI - Phase transitions in light nuclei. PMID- 9967722 TI - Chemical potentials of pi - and pi + in heavy-ion collisions. PMID- 9967723 TI - Temperature and mass dependence of level density parameter. PMID- 9967724 TI - Relation between bound state radius and scattering length: Exactly solvable relativistic model. PMID- 9967725 TI - Comment on "Interpretation of the fine structure in the 14C radioactive decay of 223Ra" PMID- 9967727 TI - Comment on "Isospin forbidden ( alpha,d) transitions to the low-lying states in 26Al" PMID- 9967726 TI - Reply to "Comment on 'Interpretation of the fine structure in the 14C radioactive decay of 223Ra' " PMID- 9967728 TI - Energy partition in near-barrier strongly damped collisions 58Ni+208Pb. PMID- 9967729 TI - Systematic behavior of the neutron-deficient molybdenum nuclei. PMID- 9967730 TI - Particle multiplicity dependence of high-energy photon production in a heavy-ion reaction. PMID- 9967731 TI - Correlation between E2 and M1 transition strength in even-even vibrational, transitional, and deformed nuclei. PMID- 9967732 TI - Elastic scattering of N-, L-, and S-type polarized 794 MeV protons from an ND3 target polarized in the S-L plane. PMID- 9967733 TI - Measurement of spin-correlation parameters ALL and ASL in p-p elastic scattering from 500 to 800 MeV. PMID- 9967735 TI - Electromagnetic static moments of deuteron in the Bethe-Salpeter formalism. PMID- 9967734 TI - Theoretical study of 4He(e,e')4He* PMID- 9967736 TI - Decay modes of 31Ar and first observation of beta -delayed three-proton radioactivity. PMID- 9967737 TI - Behavior of the nuclear charge radii systematics in the s-d shell from muonic atom measurements. PMID- 9967739 TI - High spin states in 181Ir and backbending phenomena in the Os-Pt region. PMID- 9967738 TI - High-spin states in 166Lu. PMID- 9967740 TI - Elastic and inelastic alpha scattering on 36Ar at E alpha =40, 48, and 54 MeV. PMID- 9967741 TI - Emission temperatures from the decay of particle unstable complex nuclei. PMID- 9967742 TI - Nuclear magnetic moments of the ground states of 124I, 126I, and 130I. PMID- 9967743 TI - 19/2(-) g factor in 39K using a transient field-fusion reaction technique. PMID- 9967744 TI - Giant dipole resonance in 17O observed with the ( gamma,p) reaction. PMID- 9967745 TI - Systematics of the double giant dipole resonances in nuclei. PMID- 9967747 TI - Coriolis coupling in two-quasiparticle rotational bands of deformed even-even nuclei. PMID- 9967746 TI - Covariant description of dynamical processes in relativistic nuclear matter. PMID- 9967748 TI - Photopion cross sections and mass 14 structures. PMID- 9967750 TI - Convergence of the moments of inertia in f-p-g shell nuclei. PMID- 9967749 TI - Superdeformed single-particle orbitals in the A=190 region from Hartree-Fock plus BCS calculations. PMID- 9967751 TI - Quantum corrections to the potential energy for large amplitude collective motion. PMID- 9967752 TI - Spin determination and calculation of nuclear superdeformed bands in A~190 region. PMID- 9967753 TI - Nuclear structure anomalies arising from the use of Bonn interactions and possible resolutions. PMID- 9967754 TI - Microscopic approach to the U(6/4 x 4) PMID- 9967755 TI - 3He and 4He production by 800 MeV protons from 12C, Ti, and Pb at forward angles. PMID- 9967756 TI - Collective motion in Ar+Pb collision at beam energies between 400 and 1800 MeV/nucleon. PMID- 9967757 TI - Coincidence analyzing-power measurements of the reaction 12C(p PMID- 9967758 TI - Incomplete fusion and cluster production in heavy-ion collisions at 30 MeV/nucleon. PMID- 9967759 TI - Transverse and longitudinal polarized-neutron, polarized-93Nb scattering, and the tensor spin-spin potential. PMID- 9967760 TI - Measurement of the proton-carbon bremsstrahlung cross sections at 2.135 MeV: Testing soft-photon approximations. PMID- 9967762 TI - Elastic scattering of 5 GeV/c pions from 4He. PMID- 9967761 TI - Intermediate mass fragment emission in 36Ar+197Au collisions at E/A=35 MeV. PMID- 9967764 TI - Mass distributions in various nuclear collisions. PMID- 9967763 TI - Born-approximation amplitudes for pion production in heavy-ion collisions. PMID- 9967765 TI - Thermostatic properties of Seyler-Blanchard nuclei. PMID- 9967766 TI - Relativistic optical model analysis of 180 MeV p-bar+12C elastic and inelastic scattering. PMID- 9967767 TI - Final-state Coulomb interactions for intermediate-mass fragment emission. PMID- 9967769 TI - Dynamical string-parton model for relativistic heavy-ion collisions. PMID- 9967768 TI - 4He-4He elastic scattering and variational wave functions. PMID- 9967770 TI - Stability of quark alpha in the effective mass approximation. PMID- 9967771 TI - Multichannel scattering with nonlocal and confining potentials. I. General theory. PMID- 9967772 TI - Multichannel scattering with nonlocal and confining potentials. II. Application to a nonrelativistic quark model of the NN interaction. PMID- 9967773 TI - Regular mechanism of parity and time invariance nonconserving effects enhancement in neutron capture and scattering near p-wave compound resonances. PMID- 9967774 TI - Soliton formation in nuclear matter. PMID- 9967775 TI - In-plane polarization transfer in the 6Li(p,p') reaction and the effective NN interaction. PMID- 9967776 TI - Comparison of analyzing power predictions for pp scattering in the Coulomb nuclear interference region at 185.4 MeV. PMID- 9967777 TI - Coulomb effects in three-nucleon scattering versus charge-symmetry breaking in the 3P nucleon-nucleon interactions. PMID- 9967778 TI - Second-forbidden unique beta decays of 10Be, 22Na, and 26Al. PMID- 9967779 TI - Comment on "Resonant excitation of the reaction 180Tam( gamma, gamma ')180Ta" PMID- 9967780 TI - Reply to "Comment on 'Resonant excitation of the reaction 180Tam( gamma, gamma ')180Ta' " PMID- 9967781 TI - Comment on "p-shell nuclei in a (0+2) PMID- 9967782 TI - Reply to "Comment on 'p-shell nuclei in a (0+2) PMID- 9967783 TI - Comment on the need to introduce a T=1 quasideuteron. PMID- 9967784 TI - Reply to "Comment on the need to introduce a T=1 quasideuteron" PMID- 9967785 TI - Spin dependence in pp scattering in the Coulomb-nuclear interference region. PMID- 9967787 TI - Linkage between beta and gamma vibrational excitations in deformed nuclei. PMID- 9967786 TI - Intermediate mass fragment production in interaction 40Ar+208Pb at E/A=19.6 MeV. PMID- 9967788 TI - Effect of the neutron skin on collective states of nuclei. PMID- 9967790 TI - Resonant diproton spectrum measured using the reaction 2H(d,2p)2n at 15.7 MeV. PMID- 9967789 TI - Deep attractive NN potential as a potential for the N(1440)-N system. PMID- 9967792 TI - Can the quadrupole form factors of the N--> Delta transition be determined model independently? PMID- 9967791 TI - Coulomb screening in low-energy nuclear reactions. PMID- 9967794 TI - Eta photoproduction via 2H( gamma, eta )2H* PMID- 9967793 TI - Delta degrees of freedom in trinuclei. II. The Hannover Delta Delta model. PMID- 9967795 TI - Comparison of giant dipole resonance decay in stiff 92Mo and soft 100Mo excited nuclei. PMID- 9967797 TI - 77Se(t,p)79Se reaction at 17 MeV. PMID- 9967796 TI - [16O] PMID- 9967798 TI - Determination of neutron and proton multipole matrix elements in 208Pb from pi - and pi + scattering at 180 MeV. PMID- 9967799 TI - Prolate and oblate band structures in odd-odd 186,188Au. PMID- 9967800 TI - Systematic study of low-spin states in even Cd nuclei. PMID- 9967802 TI - Large-N scaling behavior in the pairing model. PMID- 9967801 TI - Spin-tensor analysis of realistic shell model interactions. PMID- 9967803 TI - Fission from Fe and Nb reactions with heavy targets at 50-100 MeV/nucleon. PMID- 9967804 TI - Calculation for fission decay from heavy ion reactions at intermediate energies. PMID- 9967805 TI - Analyzing powers for pi +/--13C PMID- 9967806 TI - Particle emission from 71As* produced via 20Ne+51V and 15N+56Fe reactions at 530 MeV. PMID- 9967807 TI - Influence of pre-fission particle emission on fragment angular distributions studied for 208Pb(16O,f). PMID- 9967808 TI - Light particle emission near 0 degrees in the reaction 20Ne+181Ta at E/A=85 MeV. PMID- 9967809 TI - Reaction plane determination using azimuthal correlations. PMID- 9967810 TI - Near-barrier transfer reactions in the 36S+144,154Sm systems. PMID- 9967812 TI - Enhancement of the nuclear dipole sum: Microscopic approach. PMID- 9967811 TI - Coulomb-exchange contribution to proton-nucleus scattering. PMID- 9967813 TI - Elastic scattering phenomenology by inversion: 16O on 12C at 608 MeV. PMID- 9967814 TI - Angular distribution of fast protons from the pre-equilibrium process of the 165Ho( alpha,p) reaction. PMID- 9967816 TI - Nuclear transparency to intermediate-energy nucleons from (e,e'p) reactions. PMID- 9967815 TI - Proton propagation in nuclei studied in the (e,e'p) reaction. PMID- 9967817 TI - Multiple electromagnetic excitations of relativistic projectiles. PMID- 9967818 TI - Quasielastic electron scattering in quasiparticle approach. PMID- 9967820 TI - Composite nucleons and the Dirac sea. PMID- 9967819 TI - Forward baryons in relativistic nucleus-nucleus collisions. PMID- 9967821 TI - Neutron stars in the derivative coupling model. PMID- 9967822 TI - Alpha decays of light uranium isotopes. PMID- 9967823 TI - Absolute total cross sections for deuteron photodisintegration between 7 and 19 MeV. PMID- 9967824 TI - Classical approximation for the calculation of two-proton correlation functions for emissions with long lifetimes. PMID- 9967825 TI - Determination of F spin symmetry in deformed nuclei. PMID- 9967826 TI - Reconstruction of the spin dependence of one-nucleon-transfer spectroscopic sums from incomplete information. PMID- 9967827 TI - Nuclear dissipation and the feeding of superdeformed bands. PMID- 9967828 TI - Systematics of sub- and near-barrier fusion cross sections and the threshold anomaly. PMID- 9967829 TI - Off-mass-shell parity-nonconserving interactions in the nucleus. PMID- 9967830 TI - Polarized d+3He capture into the 3/2spl fusion resonance of 5Li and the role of the tensor force. PMID- 9967832 TI - Backward angle n-p differential cross section at 96 MeV. PMID- 9967831 TI - Probing alpha -particle wave functions by (d, alpha ) tensor analyzing powers. PMID- 9967833 TI - Energy dependence of the Gamow-Teller strength in p-shell nuclei observed in the (n,p) reaction. PMID- 9967834 TI - Determination of analyzing powers for 189 MeV proton elastic scattering on 12C. PMID- 9967836 TI - One-body, collective contributions to parity mixing in compound nuclear states. PMID- 9967835 TI - Pion absorption in heavy nuclei. PMID- 9967837 TI - K+ production in heavy ion collisions at far subthreshold beam energy. PMID- 9967838 TI - Saturation of B(E2) and B(M1) strengths in actinide nuclei. PMID- 9967839 TI - Prediction of first level isomeric half-lives of some even-even actinides. PMID- 9967840 TI - Absolute measurement of the differential cross section for deuteron photodisintegration from 63 to 71 MeV. PMID- 9967841 TI - Tests of a high density polarized 3He target for electron scattering. PMID- 9967842 TI - Reaction p-barp--> Lambda -bar Lambda in the meson-exchange picture. PMID- 9967843 TI - Nonmesonic weak decay of the hypertriton. PMID- 9967844 TI - Investigation of pion exchange in the NN and NN-bar systems. PMID- 9967845 TI - One-time relativistic equation and its application to nucleon-nucleon scattering. PMID- 9967846 TI - Boundary conditions for three-body scattering in configuration space. PMID- 9967847 TI - Pionic values for deuteron observables. PMID- 9967848 TI - Nonpionic effects in deuteron asymptotic observables. PMID- 9967849 TI - Observation of the low-energy octupole resonance in 208Pb by inelastic alpha scattering. PMID- 9967850 TI - The 70,72Ge(n,p)70,72Ga reactions: Suppression of Gamow-Teller strength near N=40. PMID- 9967851 TI - Isovector stretched-state excitations in the 20Ne, 24Mg, 28Si, and 32S(p,n) reactions at 136 MeV. PMID- 9967852 TI - Low-lying excitations in 176Yb and 180Hf from (p PMID- 9967853 TI - Decay of the 6(-) isomer of 164Tm. PMID- 9967854 TI - Sidebands in 219Ra. PMID- 9967855 TI - High-spin spectroscopy of 119,121I: Prolate and oblate shape coexistence. PMID- 9967856 TI - Fission branch in 259Lr and confirmation of 258Lr and 259Lr mass assignments. PMID- 9967858 TI - Double K-shell vacancy production in the electron capture decay of 125I. PMID- 9967857 TI - New nuclide 263Ha. PMID- 9967859 TI - Nuclear level densities at high excitations. PMID- 9967860 TI - Derivation of the Euler equations in Thomas-Fermi theories of a hot nuclear system. PMID- 9967861 TI - Toward a consistent random phase approximation based on the relativistic Hartree approximation. PMID- 9967862 TI - Modifications of the tensor and spin-orbit interactions and the stretched states in 208Pb. PMID- 9967863 TI - Nuclear structure properties of the double-charge-exchange transition amplitudes. PMID- 9967864 TI - Modified random phase approximation for multipole excitations at finite temperature. PMID- 9967866 TI - Fragmentation of stretched spin strength in N=Z sd-shell nuclei. PMID- 9967865 TI - Nuclear masses in the fermion dynamical symmetry model. PMID- 9967868 TI - Pre-equilibrium emission effects in the measured isomeric yield ratios in alpha induced reactions on 197Au. PMID- 9967867 TI - Quantal entropy, fluctuations, and the description of many-body ground states. PMID- 9967869 TI - Low-energy intermediate mass fragments in the 16O+12C reaction at 38 MeV/nucleon. PMID- 9967870 TI - Enhanced production of 24Na by wide-angle secondaries produced in the interaction of relativistic carbon ions with copper. PMID- 9967871 TI - Charged particle multiplicities in reactions of Ag with 40Ar of 7, 17, 27, and 34 MeV/nucleon. PMID- 9967872 TI - 14C(p,n)14N reaction at Ep=35 MeV. PMID- 9967873 TI - Neutron emission as a probe of fusion-fission and quasifission dynamics. PMID- 9967874 TI - Fast-neutron interaction with elemental zirconium, and the dispersive optical model. PMID- 9967876 TI - Canonical studies of the cluster distribution, dynamical evolution, and critical temperature in nuclear multifragmentation processes. PMID- 9967875 TI - Measurement of the 12C(p, pi 0)13N reaction by recoil detection. PMID- 9967877 TI - Electron Coulomb effects in quasielastic (e,e'p) reactions. PMID- 9967878 TI - alpha + alpha scattering in a microscopic model with monopolar distortion. PMID- 9967879 TI - Single particle analysis of (e,e') and the value of separated structure functions. PMID- 9967881 TI - Nuclear alignment: Classical dynamical model for the 238U-238U system. PMID- 9967880 TI - Geometric interpretation of the effect of the quadrupole force in the collisions of deformed nuclei. PMID- 9967882 TI - Single-step and coupled-channels calculations of pion inelastic scattering. PMID- 9967884 TI - Nucleon in nuclear matter. PMID- 9967883 TI - Wounded projectile nucleon model of the Eveto distributions in ultrarelativistic nuclear collisions. PMID- 9967885 TI - Role of nuclear binding in the European-Muon-Collaboration effect. PMID- 9967886 TI - Total cross sections and thermonuclear reaction rates for 13C(d,n) and 14C(d,n). PMID- 9967887 TI - Recoil properties of target fragments from the interaction of silver with 218 GeV 16O ions. PMID- 9967888 TI - Search for cluster radioactivity of 237Np. PMID- 9967889 TI - Nuclear structure and medium effects in p PMID- 9967890 TI - From constituent quark to current quark: Origin of the European Muon Collaboration effect. PMID- 9967891 TI - Phi meson in dense matter. PMID- 9967892 TI - Bosonic kinetics and the pion transverse momentum in heavy ion collisions. PMID- 9967893 TI - Entrance-channel effects in the population of superdeformed bands in 147,148Gd. PMID- 9967895 TI - Pure electric monopole transitions in an odd-mass nucleus. PMID- 9967894 TI - Evidence for enhanced electric dipole excitations in deformed rare earth nuclei near 2.5 MeV. PMID- 9967896 TI - Possibility of observing massive neutrino admixtures in nuclear orbital electron capture rates. PMID- 9967897 TI - Analysis of pp-pp, pi d- pi d, and pp- pi d processes concerning a narrow structure in pp-Ay data at sqrt s ~2.16 GeV. PMID- 9967898 TI - 3He and 4He proton-proton densities. PMID- 9967899 TI - Comparison of nucleon-nucleon potential models in proton-proton bremsstrahlung. PMID- 9967900 TI - Exact solution of the Faddeev equations for the harmonic oscillator. PMID- 9967901 TI - Three-body electrodisintegration of the trinucleon system. PMID- 9967902 TI - Effect of the N Delta interaction on observables of the pi NN and gamma NN systems. PMID- 9967903 TI - Generalized potential-model description of mutual scattering of the lightest p+d, d+3He nuclei and the corresponding photonuclear reactions. PMID- 9967904 TI - Bar-shape and eigenshape parameters from the zero-energy wave functions. PMID- 9967906 TI - g factors for yrast states in isotopic doublets 156,158Gd and 166,168Er. PMID- 9967905 TI - Inelastic scattering of protons, 3He, and 4He at 30 MeV/nucleon from 166Er and 176Yb and quadrupole moments of the optical potential. PMID- 9967907 TI - Inelastic transverse electron scattering on 25Mg. PMID- 9967908 TI - Transitional nucleus 101Ag: Spin-stabilized deformation in odd Ag isotopes. PMID- 9967909 TI - Level structure of 52Cr from the 51V(3He,d) reaction. PMID- 9967911 TI - Level structure of 126Xe: Population of low-spin levels in the decay of 1(+) 126Cs and theoretical description of adjacent even-even Xe nuclides. PMID- 9967910 TI - Nuclear structure functions at x>1. PMID- 9967912 TI - Thermal-neutron capture by magnesium isotopes. PMID- 9967913 TI - Decays and masses of 162,163Ta and some neighboring nuclides. PMID- 9967914 TI - Evidence for weak coupling in 145Pm. PMID- 9967915 TI - Neutron and proton dynamics of 48Ca levels and gamma -ray decays from neutron inelastic scattering. PMID- 9967917 TI - Dynamic inertia tensor at high spins. PMID- 9967916 TI - Interacting-boson-approximation study on the nuclear structural factor in double charge-exchange reactions. PMID- 9967919 TI - Isospin-induced effects in hot deformed A PMID- 9967918 TI - High-momentum components in a relativistic mean-field ground state. PMID- 9967920 TI - Chaos in the low-lying collective states of even-even nuclei: Quantal fluctuations. PMID- 9967921 TI - Ground state proton emission from heavy nuclei. PMID- 9967922 TI - Periodic structure in nuclear matter. PMID- 9967924 TI - Shape diffusion in the shell model. PMID- 9967923 TI - Limits on the lifetime of the shape isomer of 238U. PMID- 9967925 TI - Construction of shell-model interactions for Z >~ 50, N >~ 82 nuclei: Predictions for A=133-134 beta - decays. PMID- 9967926 TI - Proton-helium correlation in 94 MeV/nucleon 16O-induced reactions on Al, Ni, and Au targets. PMID- 9967928 TI - Beam-velocity fragment yields and momenta in nucleus-nucleus collisions from 20 MeV/nucleon to 200 GeV/nucleon. PMID- 9967927 TI - Quasifree subthreshold pion production in the reaction 12C(p,d pi +)11B. PMID- 9967929 TI - Alpha-particle scattering from 6Li near the alpha -d breakup threshold. PMID- 9967930 TI - Dominance of the two-nucleon mechanism in 16O( pi +,pp) at 115 MeV. PMID- 9967931 TI - Fusion evaporation-residue cross sections for 28Si+40Ca at E(28Si)=309, 397, and 452 MeV. PMID- 9967932 TI - Gamow-Teller and dipole strength distribution in 40Ca(n,p)40K reaction. PMID- 9967933 TI - Survey of the (9Be,6He) reaction on 9Be, 10B, 11B, and 12C. PMID- 9967934 TI - Proton-deuteron bremsstrahlung at 145 and 195 MeV. PMID- 9967936 TI - Extraction of nuclear spin response functions from spin observables of nucleon quasifree scattering. PMID- 9967935 TI - High energy gamma ray production in proton-induced reactions at 104, 145, and 195 MeV. PMID- 9967938 TI - Fusion barriers using the energy-density formalism: Simple analytical formula and the calculation of fusion cross sections. PMID- 9967937 TI - Finite size effect on the strong absorption radius and the barrier parameters of the heavy-ion potential. PMID- 9967939 TI - Quantal and thermal zero point motion formulae of barrier transmission probability. PMID- 9967941 TI - Color transparency and high-energy (p,2p) nuclear reactions. PMID- 9967940 TI - Semiclassical approximation to the two-step direct nucleon-nucleus reaction. PMID- 9967942 TI - Boson mappings applied to the two-color delta model. PMID- 9967943 TI - Quark and gluon condensates in nuclear matter. PMID- 9967944 TI - Quark-quark interaction with correction from nonperturbative QCD. PMID- 9967945 TI - Transport theory of relativistic heavy-ion collisions with chiral symmetry. PMID- 9967946 TI - Electromagnetic properties of the pion as a composite Nambu-Goldstone boson. PMID- 9967947 TI - Contribution of the induced tensor form factor to the A=8 beta - nu - alpha angular correlation. PMID- 9967948 TI - Study of the isoscalar weak neutral current by electron scattering from polarized deuterium. PMID- 9967949 TI - Parity violation in neutron statistical scattering. PMID- 9967950 TI - Charged- and neutral-current solar-neutrino cross sections for heavy-water Cherenkov detectors. PMID- 9967952 TI - Analysis of 8Li( alpha,n)11B below the Coulomb barrier in the potential model. PMID- 9967951 TI - Astrophysical neutrino reactions on the deuteron. PMID- 9967953 TI - Differential cross section for proton-proton bremsstrahlung at 294 MeV. PMID- 9967954 TI - Measurement of the 1H(d PMID- 9967955 TI - Pairing and high-spin states in proton-rich N=82 nuclei. PMID- 9967956 TI - Kaon photoproduction on the neutron using deuterium. PMID- 9967957 TI - Partial restoration of chiral symmetry in nuclear matter. PMID- 9967958 TI - K+-nucleus scattering and the nucleon in the nuclear medium. PMID- 9967959 TI - Analysis of the Azz measurement in np scattering at Tlab=67.5 MeV. PMID- 9967960 TI - Comment on "Pion scattering from 39K and 58Ni and virtual excitation effects on elastic scattering." PMID- 9967961 TI - Reply to "Comment on 'Kaon photoproduction, data consistency, coupling constants, and polarization observables.' " PMID- 9967962 TI - Identical bands in widely dispersed nuclei. PMID- 9967964 TI - Ab initio calculation of superdeformed bands in 192Hg. PMID- 9967963 TI - Is there incomplete mixing of states with different K quantum numbers in the neutron resonance region? PMID- 9967965 TI - S-matrix poles and phase shifts for N Delta scattering. PMID- 9967967 TI - Hard photon production in proton-deuteron reactions at intermediate energies. PMID- 9967966 TI - p+d PMID- 9967968 TI - Delta degrees of freedom in trinuclei. III. The Argonne Delta model. PMID- 9967969 TI - Folded-diagram nucleon-nucleon potential for application to the many-body problem. PMID- 9967970 TI - Kaonic hydrogen atom and low energy K-barN interaction. PMID- 9967971 TI - Pion dressing of nucleons and nuclear forces: Nonperturbative approach. PMID- 9967972 TI - Relativistic one-boson-exchange model for the nucleon-nucleon interaction. PMID- 9967973 TI - Bethe-Salpeter calculation of three-nucleon observables with multirank separable interactions. PMID- 9967974 TI - Neutron resonance spectroscopy on 113Cd: The p-wave levels. PMID- 9967975 TI - Reaction 48Ti(p, gamma )49V from 1.75 to 2.50 MeV. PMID- 9967976 TI - Spectroscopy of high spin states in 92Mo and 90Mo. PMID- 9967977 TI - Giant quadrupole resonance in Ni isotopes. PMID- 9967978 TI - Spectroscopy of 123Cs: Configuration dependent crossing frequencies. PMID- 9967979 TI - Asymmetric fission of 149Tb* from the finite-range, rotating-liquid-drop model: Mean total kinetic energies for binary fragmentation. PMID- 9967980 TI - Collective motion of nuclear mixed states: Thermal boson expansions. PMID- 9967981 TI - Anharmonicities of nuclear vibrations from periodic mean-field orbits. PMID- 9967982 TI - Hot nuclear and neutron matter with a density-dependent interaction. PMID- 9967983 TI - Octupole shapes and shape changes at high spins in the Z PMID- 9967984 TI - Spectroscopy of samarium isotopes in the sdg interacting boson model. PMID- 9967985 TI - alpha decay calculations with a realistic potential. PMID- 9967986 TI - Nuclear compressibility and the isoscalar monopole resonance in a relativistic continuum random phase approximation. PMID- 9967987 TI - Correlated finite-temperature Hartree-Fock approximation and the thermal behavior of finite systems. PMID- 9967988 TI - Relation between nuclear deformation and alpha clustering in heavy nuclei. PMID- 9967989 TI - Fission decay of giant resonances in 238U excited in alpha scattering at small momentum transfer. PMID- 9967990 TI - Elastic scattering and quasielastic transfer in the system 76,82Se+192,198Pt. PMID- 9967991 TI - Interplay between single-particle and collective degrees of freedom in the excitation of the low-lying states in 140Ce. PMID- 9967992 TI - Excitation functions for complex fragment emission in the E/A =20-100 MeV 14N+natAg, 197Au reactions. PMID- 9967993 TI - Absolute calibration of the transverse analyzing power in proton-carbon elastic scattering at 50.24 MeV. PMID- 9967994 TI - 7Li( alpha,2 alpha )3H reaction from 77 to 119 MeV. PMID- 9967996 TI - Alpha-induced reactions in iridium. PMID- 9967995 TI - Neutron yields and angular distributions produced in antiproton annihilation at rest in uranium. PMID- 9967997 TI - Neutron induced pion production on C, Al, Cu, and W at 200-600 MeV. PMID- 9967998 TI - Evolution of reaction mechanisms in the light heavy-ion system. PMID- 9967999 TI - Light particle emission in Boltzmann master equation theory of pre-equilibrium reactions. PMID- 9968000 TI - Preequilibrium to evaporation residues: Dynamical approach to intermediate energy nucleus-nucleus collisions. PMID- 9968001 TI - Peripheral three-body coupling model for knockout reactions. PMID- 9968002 TI - Statistical emission of deuterons and tritons from highly excited compound nuclei. PMID- 9968003 TI - Nucleon-nucleon correlation effects in the elastic scattering of alpha particles from 11Li at 26 MeV/nucleon. PMID- 9968004 TI - General features of nucleon-nucleus interaction in the resonating-group formulation. PMID- 9968005 TI - Two-particle azimuthal correlations in light nuclei collisions at 4.2 GeV/c per nucleon. PMID- 9968006 TI - Upper limit on the cross section for nuclear charge pickup by relativistic uranium ions. PMID- 9968008 TI - K/ pi ratios in relativistic heavy ion collisions. PMID- 9968007 TI - Electromagnetic dissociation of relativistic 28Si into p+27Al. PMID- 9968009 TI - Neutral pion condensation in quark matter including vacuum fluctuation effects. PMID- 9968011 TI - Comparison of inelastic neutrino and antineutrino scattering on nuclei. PMID- 9968010 TI - Experimental study of neutrino absorption on carbon. PMID- 9968012 TI - Neutron capture in 122,123,124Te: Critical test for s process studies. PMID- 9968013 TI - Neutron cross sections of 122Te, 123Te, and 124Te between 1 and 60 keV. PMID- 9968015 TI - Angular distributions in 109Cd. PMID- 9968014 TI - Low-momentum-transfer 180 degrees electron scattering from the 3.68 MeV 3/2(-) and the 3.85 MeV 5/2(+) states in 13C. PMID- 9968016 TI - Elastic scattering and fusion calculations for 16O+63,65Cu. PMID- 9968017 TI - K+-nucleus cross sections with a density-dependent K+N interaction. PMID- 9968018 TI - Relation between the kinematic and dynamic moments of inertia in superdeformed nuclei. PMID- 9968019 TI - Form factors and gauge invariance in pion photoproduction. PMID- 9968020 TI - Neutron skin of spherical nuclei in relativistic and nonrelativistic mean-field approaches. PMID- 9968021 TI - Relativistic nuclear matter with composite nucleons. PMID- 9968022 TI - 2H(p,n)2p spin transfer from 305 to 788 MeV. PMID- 9968023 TI - Measurement of a complete set of analyzing powers and cross section of the kinematically complete breakup reaction 4He(d PMID- 9968024 TI - Inelastic scattering of polarized protons from 4He at 500 and 800 MeV. PMID- 9968026 TI - Extracting a value of the deuteron radius by reanalysis of the experimental data. PMID- 9968025 TI - Two-nucleon absorption of pi + in 4He at T pi +=114 and 162 MeV. PMID- 9968027 TI - Slow proton production in semi-inclusive deep-inelastic neutrino scattering on hydrogen and deuterium. PMID- 9968028 TI - Delta degrees of freedom in trinuclei. IV. Delta Delta Delta effects. PMID- 9968029 TI - Effects of Delta -isobar degrees of freedom on low-energy electroweak transitions in few-body nuclei. PMID- 9968030 TI - Hyperspherical approach for the trinucleon system with hard-core potential. PMID- 9968031 TI - Charge symmetry breaking two-pion exchange. PMID- 9968032 TI - Parity-violating asymmetry in quasielastic e-d scattering. PMID- 9968034 TI - Inelastic alpha scattering from 20Ne. PMID- 9968033 TI - Second minimum lifetime measurements in 133Nd and 137Nd. PMID- 9968035 TI - Transition densities of collective excitations in 118Sn. PMID- 9968036 TI - High resolution electron scattering from high spin states in 208Pb. PMID- 9968038 TI - Spin and parity measurements in 128,129La. PMID- 9968037 TI - Double giant dipole resonance in the ( pi -, pi +) reaction. PMID- 9968039 TI - Semidecoupled band structure in odd-odd 134La and 136Pr. PMID- 9968041 TI - Rotation and wobbling motion in triaxially deformed nuclei. PMID- 9968040 TI - Proton resonances in 30P. PMID- 9968042 TI - Spin-orbit splitting for single-particle and single-hole energies: Interplay of relativity and core polarization. PMID- 9968043 TI - Analysis of a three-dimensional cranking in a simple model. PMID- 9968044 TI - Properties of dense nuclear and neutron matter with relativistic nucleon-nucleon interactions. PMID- 9968046 TI - Systematics of the deduced fission barriers for the doubly even transactinium nuclei. PMID- 9968045 TI - Comparison of two approaches to microscopy of the interacting boson model. PMID- 9968047 TI - P-A in the 48Ca(p,n)48Sc reaction at 135 MeV. PMID- 9968048 TI - Effects of 6Li excitation in 64Zn(d PMID- 9968050 TI - Heavy-ion charge-exchange reactions and the measurement of Gamow-Teller strength. PMID- 9968049 TI - Pion correlations in 1.8A GeV Ar on KCl and La and 1.2A GeV Xe on La. PMID- 9968051 TI - Capture reactions in the 40,48Ca+197Au and 40,48Ca+208Pb systems. PMID- 9968052 TI - Coulomb and nuclear effects in direct breakup of 54-MeV 7Li+12C, 197Au. PMID- 9968053 TI - Core polarization effects in (p PMID- 9968054 TI - Equivalent local potentials for energy dependent nonlocal interactions. PMID- 9968055 TI - Dispersion relation analysis of d+208Pb elastic scattering. PMID- 9968056 TI - Microscopic analysis of alpha scattering from 28Si at 40 and 45 MeV. PMID- 9968057 TI - Break-up effect on the elastic scattering and the optical potential of 11Li. PMID- 9968058 TI - Strong absorption model and its associated potential. PMID- 9968059 TI - Measurement of d-C and d-Al total cross sections in the incident momentum range 2.0-4.0 GeV/c. PMID- 9968061 TI - Nuclear stopping power at ~15 GeV/nucleon. PMID- 9968062 TI - Hadronic matter in a nontopological soliton model. PMID- 9968060 TI - Global transverse energy distributions in relativistic nuclear collisions at 14.6A GeV/c. PMID- 9968063 TI - Vertex corrections to vacuum polarization in hadronic field theories. PMID- 9968064 TI - Reaction 36Ar(p, gamma )37K in explosive hydrogen burning. PMID- 9968066 TI - J pi composition of the spin-dipole resonance in 40Ca. PMID- 9968065 TI - Closed form theory of elastic breakup and applications to astrophysically relevant heavy ion reactions. PMID- 9968067 TI - Excitation functions of 46-50Ti(n,p)46-50Sc processes. PMID- 9968068 TI - Extended selection rules for allowed beta decays in actinides. PMID- 9968069 TI - Phenomenological approach to high-spin quantum fields based on the Weinberg formalism. PMID- 9968070 TI - Empirical model for three-quasiparticle states. PMID- 9968071 TI - Partial transitions in the nonmesonic decay of hypernuclei. PMID- 9968072 TI - Effect of inelasticity in charge symmetry breaking neutron-proton scattering. PMID- 9968073 TI - Two neutron removal in relativistic nucleus-nucleus reactions. PMID- 9968075 TI - Eikonal scattering from complex systems. PMID- 9968074 TI - Dynamical dependence of thermal phase transformations in finite systems. PMID- 9968076 TI - Parametrization of thermal photon emission rates from mesonic matter. PMID- 9968077 TI - Delayed neutron alignment in 117I. PMID- 9968078 TI - Analyzing power measurements for p-d radiative capture. PMID- 9968079 TI - Fluctuations and intermittency in multifragmentation processes. PMID- 9968081 TI - Implications of the 14C( alpha, gamma )18O reaction for nonstandard big bang nucleosynthesis. PMID- 9968080 TI - Signature splitting in octupole bands of deformed nuclei. PMID- 9968082 TI - Dynamical freeze-out criterion in Bjorken's hydrodynamical model. PMID- 9968083 TI - Distortion effects in the quasifree 12C(d PMID- 9968084 TI - Density effects in the (e,e'p) reaction. PMID- 9968085 TI - np elastic spin-transfer measurements at 485 and 635 MeV. PMID- 9968087 TI - Effect of the three-nucleon force on the three-nucleon ground state: Reducible and irreducible contributions. PMID- 9968086 TI - He4( pi, pi 'p)H3 reaction near the P33 pi -nucleon resonance. PMID- 9968088 TI - Delta 33-isobar contribution to the soft nucleon-nucleon potentials. I. 2 pi exchange potentials. PMID- 9968089 TI - Delta 33-isobar contribution to the soft nucleon-nucleon potentials. II. pi rho exchange potentials. PMID- 9968090 TI - pi NN system with two-term potentials in the P33 and P11 pi N channels. PMID- 9968091 TI - Oblate collectivity in 197Pb. PMID- 9968092 TI - 45Sc(d,p)46Sc reaction. PMID- 9968093 TI - Resonant formation of pionic atoms with neutron collisions. PMID- 9968094 TI - Do nucleons in abnormal-parity states contribute to deformation? PMID- 9968095 TI - Double-beta decay to excited 0(+) states: Decay of 100Mo. PMID- 9968096 TI - Two-loop corrections for nuclear matter in the Walecka model with form factors. PMID- 9968097 TI - Structure of even Ge isotopes by means of interacting boson model with a fermion pair model. PMID- 9968098 TI - Systematic study of the effect of short range correlations on the occupation numbers of the shell model orbits in light nuclei. PMID- 9968099 TI - Isoscalar transition rates from inelastic alpha scattering. PMID- 9968100 TI - Model test of boson mappings. PMID- 9968101 TI - Approach to the relativistic extended Thomas-Fermi expansion for Green's functions, phase-space densities, and densities. PMID- 9968102 TI - Characterization of octupole correlations in the Lipkin model. PMID- 9968103 TI - Fusion and elastic scattering for the 12C+144Sm system at energies near to the Coulomb barrier. PMID- 9968104 TI - Isomeric yield ratios and excitation functions in alpha -induced reactions on 107,109Ag. PMID- 9968105 TI - Inclusive neutron cross sections from Ne-Pb collisions at 790 MeV/nucleon. PMID- 9968106 TI - Heavy residue production in 215 MeV 16O+27Al reactions. PMID- 9968108 TI - Multiple scattering theory of proton elastic scattering at intermediate energies. PMID- 9968107 TI - Pion absorption in light nuclei. PMID- 9968109 TI - Analysis of neutron+nucleus scattering data with nonlocal optical potentials based on the resonating-group formulation. PMID- 9968110 TI - Nuclear fission with diffusive dynamics. PMID- 9968112 TI - Metastable exotic multihypernuclear objects. PMID- 9968111 TI - Charged particle multiplicity in 28Si+Al, Cu, and Pb reactions at Elab=14.6 GeV/nucleon. PMID- 9968113 TI - Measuring the QCD transition temperature with resonant dileptons in ultrarelativistic nuclear collisions. PMID- 9968114 TI - Confining quark condensate model of the nucleon. PMID- 9968115 TI - Neutrino- and antineutrino-deuteron elastic scattering and the axial isoscalar nucleon current. PMID- 9968116 TI - Recoil effects and CP violation in neutron scattering. PMID- 9968118 TI - In-plane particle-residue correlations in the 40Ar(1100 MeV)+24Mg reaction. PMID- 9968117 TI - Decay property of 20Na for the onset mechanism of the rapid-proton process. PMID- 9968119 TI - beta 4 systematics in rare-earth and actinide nuclei: sdg interacting boson model description. PMID- 9968120 TI - Probing time scales in projectile fragmentation processes at intermediate energies. PMID- 9968121 TI - Near-barrier fusion of 11Li with heavy spherical and deformed targets. PMID- 9968123 TI - Determining the 12C( alpha, gamma ) 16O cross section from Coulomb dissociation. PMID- 9968122 TI - One-body dissipation at intermediate nuclear connection regimes. PMID- 9968124 TI - Erratum: 40Ca photoneutron cross section above the giant dipole resonance PMID- 9968125 TI - Particle-particle correlations: Independent particle emission versus sequential decay of heavy fragments. PMID- 9968126 TI - Lifetime measurement of the first 2(+) state in 122,124,126Ba. PMID- 9968128 TI - Spin-triplet strength in the 3H(p PMID- 9968127 TI - Rise and fall of multifragment emission at relativistic energy. PMID- 9968129 TI - Pion absorption followed by multinucleon emission. PMID- 9968130 TI - Measurements of mean reaction times for fusion-fission and fusion-evaporation processes in the 28Si+28Si interaction. PMID- 9968131 TI - Fragment production in heavy-ion reactions. PMID- 9968132 TI - QCD sum rules for vector mesons in the nuclear medium. PMID- 9968133 TI - Search for identical bands at normal deformation in the A=130 mass region. PMID- 9968134 TI - Mechanism for nuclear disassembly of the Ar+Th and Pb+Au systems at intermediate energies. PMID- 9968136 TI - Near-threshold proton-induced neutral pion production from deuterium. PMID- 9968135 TI - Dynamical hindrance to neutron-rich-projectile-induced fusion. PMID- 9968137 TI - Charge symmetry breaking in n PMID- 9968139 TI - Exclusive deuteron electrodisintegration with polarized electrons and a polarized target. PMID- 9968138 TI - Elastic photon scattering from 4He: Charge symmetry problem. PMID- 9968140 TI - Three-body collapse for Tabakin potentials and the Thomas effect. PMID- 9968141 TI - Pion double charge exchange on 128,130Te. PMID- 9968142 TI - Observation of high-spin states in the N=84 nucleus 152Er and comparison with shell-model calculations. PMID- 9968143 TI - Isospin character of the transition to the 0.803-MeV state in 206Pb from pi +/- scattering at 180 MeV. PMID- 9968144 TI - Excitation of 6(-) and 7(+) stretched states in the 38Ar(p,n)38K reaction at 135 MeV. PMID- 9968145 TI - Decay of 120Ba. PMID- 9968146 TI - Rotational band structure in 75Se. PMID- 9968147 TI - Breakup-fusion analyses of the 40Ca(6Li,d)44Ti reactions and alpha -cluster structure in 44Ti. PMID- 9968148 TI - Intruder analog states: New classification of particle-hole excitations near closed shells. PMID- 9968149 TI - Semimicroscopic algebraic study of the alpha -cluster states of the 18O nucleus. PMID- 9968150 TI - Temperature dependent resonant random phase approximation. PMID- 9968151 TI - Validity of the quasiparticle approximation in nuclear matter. PMID- 9968153 TI - Dynamical microscopic three-cluster description of 6Li. PMID- 9968152 TI - Interpretation of the scalar fields of the relativistic Brueckner-Hartree-Fock formalism. PMID- 9968154 TI - Resonant and nonresonant behavior of the heavy-ion reaction 14C+12C. PMID- 9968155 TI - Quantitative studies of continuum gamma-ray correlations in 170Hf. PMID- 9968156 TI - Reactions 58,64Ni(p, pi +/-) at 201 MeV. PMID- 9968157 TI - Energy dependence of the 6Li( alpha,2 alpha )pn reaction from 77 to 119 MeV. PMID- 9968159 TI - Giant dipole resonance decay from fusion-fission and quasifission of hot thorium nuclei. PMID- 9968158 TI - Exclusive 16O( gamma, pi -p) reaction in the Delta resonance region. PMID- 9968161 TI - Fragmentation of 197Au by 21 MeV/nucleon 129Xe. PMID- 9968162 TI - K+ total cross sections on 12C and medium effects in nuclei. PMID- 9968160 TI - Evolution of fragment-fragment correlations in reactions of 197Au and 107,109Ag with 40Ar from 7A to 34A MeV. PMID- 9968164 TI - Analysis of the transverse momentum collective motion in heavy-ion collisions below 100 MeV/nucleon. PMID- 9968163 TI - Mutual inelastic excitation in the 28Si+28Si reaction at 19.7 and 30 MeV/nucleon. PMID- 9968166 TI - Inelastic breakup in heavy-ion reactions. PMID- 9968165 TI - Cluster-dynamical approach to N-body scattering.